Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Input: MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWEPKSKNASKVANKGKSKS

Output: cytoplasm ; exosome (RNase complex) ; nuclear exosome (RNase complex) ; nucleolus ; nucleoplasm ; nucleus ; transcription repressor complex ; DNA binding ; nuclear receptor binding ; RNA binding ; transcription corepressor activity ; apoptotic process ; maturation of 5.8S rRNA ; regulation of gene expression


GO Terms Prediction

Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: focal adhesion ; nucleoplasm ; presynapse ; synapse ; GTPase activator activity ; metal ion binding ; small GTPase binding ; brain development ; regulation of ARF protein signal transduction ; regulation of G protein-coupled receptor signaling pathway ; synaptic vesicle recycling


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: cytosol ; early endosome ; early endosome membrane ; intracellular membrane-bounded organelle ; nucleolus ; plasma membrane ; WASH complex ; phosphatidylinositol phosphate binding ; retromer complex binding ; endosomal transport ; protein localization to endosome ; protein transport ; regulation of Arp2/3 complex-mediated actin nucleation ; retrograde transport, endosome to Golgi


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: cytosol ; extracellular exosome ; extracellular region ; extracellular space ; intercellular bridge ; mitochondrion ; nucleoplasm ; perinuclear region of cytoplasm ; plasma membrane ; protein-containing complex ; specific granule ; specific granule lumen ; tertiary granule lumen ; cadherin binding ; structural molecule activity ; cell adhesion ; positive regulation of substrate adhesion-dependent cell spreading ; signal transduction


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: extracellular exosome ; Golgi lumen ; plasma membrane ; antimicrobial humoral immune response mediated by antimicrobial peptide ; killing of cells of another organism


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Input: MAGGPPNTKAEMEMSLAEELNHGRQGENQEHLVIAEMMELGSRSRGASQKKQKLEQKAAGSASAKRVWNMTATRPKKMGSQLPKPRMLRESGHGDAHLQEYAGNFQGIRFHYDRNPGTDAVAQTSLEEFNVLEMEVMRRQLYAVNRRLRALEEQGATWRHRETLIIAVLVSASIANLWLWMNQ

Output: endoplasmic reticulum ; endoplasmic reticulum membrane ; mitochondria-associated endoplasmic reticulum membrane ; mitochondrial outer membrane ; identical protein binding ; ubiquitin protein ligase binding ; apoptotic process ; negative regulation of apoptotic process ; negative regulation of mitochondrial calcium ion concentration


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: dendrite ; endoplasmic reticulum ; endoplasmic reticulum lumen ; endoplasmic reticulum membrane ; extracellular space ; Golgi lumen ; intracellular membrane-bounded organelle ; membrane ; FAD binding ; oxidoreductase activity ; protein-disulfide reductase activity ; thiol oxidase activity ; brown fat cell differentiation ; cell redox homeostasis ; cellular response to hypoxia ; chaperone cofactor-dependent protein refolding ; endoplasmic reticulum unfolded protein response ; extracellular matrix organization ; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ; peptidyl-proline hydroxylation to 4-hydroxy-L-proline ; protein folding ; protein folding in endoplasmic reticulum ; protein maturation by protein folding ; protein modification process ; release of sequestered calcium ion into cytosol ; response to endoplasmic reticulum stress ; response to oxidative stress ; response to temperature stimulus


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytosol ; nuclear speck ; nucleoplasm ; RNA binding ; mRNA splicing, via spliceosome


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: membrane ; plasma membrane ; voltage-gated sodium channel complex ; Z disc ; sodium channel inhibitor activity ; sodium channel regulator activity ; transmembrane transporter binding ; voltage-gated monoatomic ion channel activity ; voltage-gated sodium channel activity involved in cardiac muscle cell action potential ; atrial cardiac muscle cell action potential ; cardiac muscle cell action potential involved in contraction ; cardiac muscle contraction ; membrane depolarization ; membrane depolarization during action potential ; membrane depolarization during cardiac muscle cell action potential ; nervous system development ; positive regulation of heart rate ; positive regulation of sodium ion transport ; protein localization to plasma membrane ; regulation of atrial cardiac muscle cell membrane depolarization ; regulation of heart rate by cardiac conduction ; regulation of sodium ion transmembrane transporter activity ; regulation of ventricular cardiac muscle cell membrane depolarization ; SA node cell action potential ; sensory perception of pain ; sodium ion transmembrane transport ; sodium ion transport ; ventricular cardiac muscle cell action potential


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytosol ; Golgi membrane ; lamellipodium ; plasma membrane ; enzyme binding ; guanyl-nucleotide exchange factor activity ; metal ion binding ; phosphatidylinositol phospholipase C activity ; phospholipase C activity ; small GTPase binding ; calcium-mediated signaling ; cytoskeleton organization ; diacylglycerol biosynthetic process ; epidermal growth factor receptor signaling pathway ; glomerulus development ; heart development ; inositol phosphate-mediated signaling ; lipid catabolic process ; phosphatidylinositol-mediated signaling ; phospholipase C-activating G protein-coupled receptor signaling pathway ; positive regulation of cytosolic calcium ion concentration ; positive regulation of lamellipodium assembly ; positive regulation of MAPK cascade ; Ras protein signal transduction ; regulation of cell growth ; regulation of G protein-coupled receptor signaling pathway ; regulation of protein kinase activity ; regulation of Ras protein signal transduction ; regulation of smooth muscle contraction ; release of sequestered calcium ion into cytosol


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: cytosol ; intracellular membrane-bounded organelle ; peroxisomal matrix ; (S)-2-hydroxy-acid oxidase activity ; FMN binding ; glyoxylate oxidase activity ; fatty acid alpha-oxidation ; glycine biosynthetic process ; glycolate catabolic process ; response to oxidative stress


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: cytoplasm ; intercellular bridge ; microtubule ; microtubule cytoskeleton ; mitotic spindle ; GTP binding ; GTPase activity ; metal ion binding ; structural constituent of cytoskeleton ; microtubule cytoskeleton organization ; microtubule polymerization ; microtubule-based process ; mitotic cell cycle ; platelet aggregation ; platelet formation ; spindle assembly ; thyroid gland development ; thyroid hormone transport


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: centrosome ; ciliary basal body ; cytoplasm ; membrane ; cartilage development ; cell projection organization ; cranial skeletal system development ; neural crest cell development ; ossification ; positive regulation of bone development ; positive regulation of cartilage development ; positive regulation of cilium assembly


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: cytoplasm ; cytosol ; ADP phosphatase activity ; glycerol-1-phosphatase activity ; glycerol-3-phosphatase activity ; magnesium ion binding ; phosphoglycolate phosphatase activity ; protein tyrosine phosphatase activity ; dephosphorylation ; glycerol biosynthetic process ; glycerophospholipid metabolic process ; negative regulation of gluconeogenesis ; peptidyl-tyrosine dephosphorylation


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytoplasm ; cytosol ; exon-exon junction complex ; nuclear body ; nuclear speck ; nucleolus ; nucleoplasm ; nucleus ; mRNA binding ; mRNA processing ; mRNA transport ; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ; positive regulation of gene expression ; regulation of translation ; RNA splicing


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cilium ; early endosome ; endosome ; ESCRT-0 complex ; phosphatidylinositol binding ; ubiquitin binding ; endosome to lysosome transport ; ephrin receptor signaling pathway ; negative regulation of MAPK cascade ; protein localization to non-motile cilium ; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ; response to hermaphrodite contact


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytoplasm ; fibrillar center ; intercellular bridge ; microtubule cytoskeleton ; nucleoplasm ; nucleus ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; estrogen response element binding ; nuclear steroid receptor activity ; protein domain specific binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; sequence-specific DNA binding ; sequence-specific double-stranded DNA binding ; steroid binding ; zinc ion binding ; cartilage development ; negative regulation of transcription by RNA polymerase II ; positive regulation of cellular response to insulin stimulus ; positive regulation of DNA-templated transcription ; positive regulation of transcription by RNA polymerase II ; regulation of cell population proliferation ; regulation of DNA-templated transcription ; regulation of ossification ; regulation of osteoblast differentiation ; regulation of osteoclast differentiation ; regulation of transcription by RNA polymerase II


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: plasma membrane ; carbohydrate:proton symporter activity ; kinase activity ; protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity ; protein-phosphocysteine-sugar phosphotransferase activity ; phosphoenolpyruvate-dependent sugar phosphotransferase system ; phosphorylation


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cytoplasm ; plasma membrane ; ATP binding ; identical protein binding ; protein homodimerization activity ; protein serine kinase activity ; protein serine/threonine kinase activity ; cell cycle ; lymphocyte aggregation ; protein autophosphorylation ; protein phosphorylation ; regulation of lymphocyte migration


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: actin cytoskeleton ; cell cortex ; cell junction ; COP9 signalosome ; cytoskeleton ; nucleoplasm ; plasma membrane ; actin binding ; PH domain binding ; spectrin binding ; structural molecule activity ; actin cytoskeleton organization ; actomyosin structure organization ; cell cycle ; cell division ; cortical actin cytoskeleton organization ; positive regulation of protein localization to cell cortex ; regulation of cell shape


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: cytoplasm ; cytosol ; nucleus ; ATP binding ; cGMP binding ; cGMP-dependent protein kinase activity ; metal ion binding ; protein serine kinase activity ; chemosensory behavior ; chemotaxis ; chemotropism ; determination of adult lifespan ; insulin receptor signaling pathway ; larval feeding behavior ; negative regulation of calcium-mediated signaling ; negative regulation of cell growth ; negative regulation of cGMP-mediated signaling ; negative regulation of cyclic nucleotide-gated ion channel activity ; negative regulation of dauer larval development ; negative regulation of multicellular organism growth ; negative regulation of organ growth ; negative regulation of transforming growth factor beta receptor signaling pathway ; olfactory learning ; peptidyl-serine phosphorylation ; positive regulation of cellular response to alcohol ; positive regulation of cGMP-mediated signaling ; positive regulation of chemotaxis ; positive regulation of cyclic-nucleotide phosphodiesterase activity ; positive regulation of gene expression ; positive regulation of oviposition ; protein phosphorylation ; receptor guanylyl cyclase signaling pathway ; regulation of eating behavior ; regulation of gene expression ; regulation of multicellular organism growth ; regulation of oviposition ; response to alcohol ; response to hydrogen peroxide ; response to odorant ; response to oxygen levels ; sensory perception of bitter taste ; signal transduction ; sleep


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Input: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED

Output: protein-DNA complex ; transcription regulator complex ; core promoter sequence-specific DNA binding ; DNA binding ; DNA-binding transcription repressor activity ; nickel cation binding ; sequence-specific DNA binding ; transcription cis-regulatory region binding ; negative regulation of DNA-templated transcription initiation ; regulation of DNA-templated transcription ; response to nickel cation


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytosol ; glycerol-3-phosphate dehydrogenase complex ; plasma membrane ; flavin adenine dinucleotide binding ; FMN binding ; glycerol-3-phosphate dehydrogenase (quinone) activity ; sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity ; anaerobic respiration ; glycerol catabolic process ; glycerol-3-phosphate catabolic process


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Input: MRQLPAGPSSLACSGCKAGRLVTVPFSSRDAEDQGSREGIGWQPPGRSWAHTTEQEGKHQVAKATVHPPGPDALLLNQVDPVQCCPTRL

Output: axon ; axon terminus ; cytosol ; dendrite ; nucleoplasm ; nucleus ; protein-DNA complex ; voltage-gated potassium channel complex ; calcium ion binding ; calcium-dependent protein binding ; DNA binding ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; potassium channel regulator activity ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; sequence-specific DNA binding ; transmembrane transporter binding ; behavioral response to pain ; intracellular protein transport ; negative regulation of DNA-templated transcription ; negative regulation of transcription by RNA polymerase II ; potassium ion transport ; regulation of neuron apoptotic process ; regulation of potassium ion transmembrane transport ; response to pain ; sensory perception of pain


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Input: MSDAVTIRTRKVISNPLLARKQFVVDVLHPNRANVSKDELREKLAEVYKAEKDAVSVFGFRTQFGGGKSVGFGLVYNSVAEAKKFEPTYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTGKRLAKKVARRNAD

Output: cytosol ; cytosolic small ribosomal subunit ; mitochondrion ; structural constituent of ribosome ; cytoplasmic translation ; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytoplasm ; cytosol ; ATP binding ; metal ion binding ; pyruvate carboxylase activity ; gluconeogenesis ; pyruvate metabolic process


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: basement membrane ; collagen type IV trimer ; extracellular matrix ; extracellular space ; extracellular matrix structural constituent ; extracellular matrix structural constituent conferring tensile strength ; cellular component organization ; embryo development ending in birth or egg hatching ; extracellular matrix organization ; gonad morphogenesis ; protein localization ; regulation of distal tip cell migration


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytoplasm ; ATP binding ; identical protein binding ; MAP kinase kinase kinase activity ; protein kinase activity ; protein serine kinase activity ; SAM domain binding ; cell wall integrity MAPK cascade ; invasive growth in response to glucose limitation ; osmosensory signaling MAPK cascade ; osmosensory signaling pathway via Sho1 osmosensor ; pheromone response MAPK cascade ; pheromone-dependent signal transduction involved in conjugation with cellular fusion ; protein phosphorylation ; pseudohyphal growth ; regulation of transposition, RNA-mediated ; signal transduction involved in filamentous growth


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: axon ; cytoplasm ; cytoplasmic side of plasma membrane ; cytoplasmic vesicle ; cytoplasmic vesicle membrane ; cytosol ; dendrite ; melanosome membrane ; mitochondrion ; neuron projection ; neuronal cell body ; nucleus ; perikaryon ; perinuclear region of cytoplasm ; smooth endoplasmic reticulum ; synaptic vesicle ; terminal bouton ; amino acid binding ; dopamine binding ; enzyme binding ; ferric iron binding ; ferrous iron binding ; identical protein binding ; monooxygenase activity ; oxygen binding ; protein domain specific binding ; small molecule binding ; tetrahydrobiopterin binding ; tyrosine 3-monooxygenase activity ; aminergic neurotransmitter loading into synaptic vesicle ; animal organ morphogenesis ; catecholamine biosynthetic process ; cellular response to alkaloid ; cellular response to glucose stimulus ; cellular response to growth factor stimulus ; cellular response to manganese ion ; cellular response to nicotine ; cellular response to xenobiotic stimulus ; cerebral cortex development ; circadian sleep/wake cycle ; dopamine biosynthetic process ; dopamine biosynthetic process from tyrosine ; eating behavior ; embryonic camera-type eye morphogenesis ; epinephrine biosynthetic process ; eye photoreceptor cell development ; fatty acid metabolic process ; glycoside metabolic process ; heart development ; hyaloid vascular plexus regression ; isoquinoline alkaloid metabolic process ; learning ; locomotory behavior ; mating behavior ; memory ; multicellular organism aging ; neurotransmitter biosynthetic process ; norepinephrine biosynthetic process ; phthalate metabolic process ; phytoalexin metabolic process ; regulation of heart contraction ; response to activity ; response to amphetamine ; response to corticosterone ; response to electrical stimulus ; response to estradiol ; response to ethanol ; response to ether ; response to herbicide ; response to hypoxia ; response to immobilization stress ; response to isolation stress ; response to light stimulus ; response to lipopolysaccharide ; response to nutrient levels ; response to peptide hormone ; response to pyrethroid ; response to salt stress ; response to water deprivation ; response to zinc ion ; sensory perception of sound ; social behavior ; sphingolipid metabolic process ; synaptic transmission, dopaminergic ; terpene metabolic process ; visual perception


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: mitochondrial matrix ; mitochondrion ; iron ion binding ; iron-sulfur cluster binding ; iron-sulfur cluster assembly ; protein maturation by  cluster transfer ; protein maturation by iron-sulfur cluster transfer


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: membrane raft ; myelin sheath ; plasma membrane ; structural constituent of myelin sheath ; axon development ; central nervous system myelination ; extracellular matrix assembly ; negative regulation of protein localization to cell surface ; negative regulation of serotonin uptake ; ossification ; positive regulation of bone mineralization ; protein transport ; regulation of actin cytoskeleton organization ; regulation of focal adhesion assembly


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: cell surface ; extracellular region ; fungal-type cell wall ; mitochondrial inner membrane ; mitochondrial outer membrane ; hydrolase activity, acting on glycosyl bonds ; autophagy of mitochondrion ; division septum assembly ; fungal-type cell wall biogenesis ; fungal-type cell wall organization ; polysaccharide catabolic process


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cytoplasm ; peroxisomal matrix ; peroxisomal membrane ; ATP binding ; medium-chain fatty acid-CoA ligase activity ; mRNA binding ; oxalate-CoA ligase activity ; fatty acid metabolic process ; oxalate catabolic process


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Input: MANDLVQARDNSQVFGVARIYASFNDTFVHVTDLSGKETIARVTGGMKVKADRDESSPYAAMLAAQDVAAKCKEVGITAVHVKIRATGGTRTKTPGPGGQAALRALARSGLRIGRIEDVTPVPSDSTRKKGGRRGRRL

Output: cytosol ; cytosolic small ribosomal subunit ; nucleolus ; small-subunit processome ; mRNA 5'-UTR binding ; RNA binding ; small ribosomal subunit rRNA binding ; structural constituent of ribosome ; cytoplasmic translation ; maturation of SSU-rRNA ; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ; ribosomal small subunit assembly ; translation


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: catalytic step 2 spliceosome ; nuclear periphery ; spliceosomal complex ; mRNA binding ; generation of catalytic spliceosome for second transesterification step ; mRNA 3'-splice site recognition ; mRNA branch site recognition ; mRNA splicing, via spliceosome


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: axon terminus ; cytoplasm ; dendrite ; mitochondrion ; neuronal cell body ; nucleoplasm ; nucleus ; chromatin binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; double-stranded DNA binding ; nuclear receptor coactivator activity ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; sequence-specific double-stranded DNA binding ; transcription cis-regulatory region binding ; cellular response to gamma radiation ; cellular response to lipid ; cellular response to testosterone stimulus ; gene expression ; liver development ; lung development ; positive regulation of DNA-templated transcription ; positive regulation of neuron death ; positive regulation of transcription by RNA polymerase II ; regulation of DNA-templated transcription ; regulation of transcription by RNA polymerase II ; response to fibroblast growth factor ; response to light stimulus


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: extracellular space ; vesicle ; BMP receptor binding ; cytokine activity ; growth factor activity ; allantois development ; anterior head development ; cardiac muscle tissue development ; cardiac septum morphogenesis ; cartilage development ; chorio-allantoic fusion ; ear development ; endocardial cushion formation ; heart trabecula morphogenesis ; hindbrain development ; male genitalia development ; negative regulation of aldosterone biosynthetic process ; negative regulation of cell population proliferation ; negative regulation of cortisol biosynthetic process ; negative regulation of insulin-like growth factor receptor signaling pathway ; negative regulation of steroid biosynthetic process ; neural fold elevation formation ; ossification ; pattern specification process ; pericardium morphogenesis ; pharyngeal system development ; positive regulation of cell population proliferation ; positive regulation of dendrite development ; positive regulation of epithelial cell proliferation ; positive regulation of pathway-restricted SMAD protein phosphorylation ; positive regulation of transcription by RNA polymerase II ; skeletal system development ; SMAD protein signal transduction ; type B pancreatic cell development


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytoplasm ; cytosol ; aryl sulfotransferase activity ; sulfotransferase activity ; 3'-phosphoadenosine 5'-phosphosulfate metabolic process ; epithelial cell differentiation ; ethanol catabolic process ; flavonoid metabolic process ; phenol-containing compound metabolic process ; sulfation ; thyroid hormone metabolic process ; xenobiotic metabolic process


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: cell periphery ; extracellular region ; fungal-type cell wall ; incipient cellular bud site ; membrane ; glycosyltransferase activity ; hydrolase activity, hydrolyzing O-glycosyl compounds ; carbohydrate metabolic process ; cell wall chitin metabolic process ; fungal-type cell wall organization


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: apical plasma membrane ; axon ; chromatin ; cytoplasm ; cytosol ; dendrite ; neuronal cell body ; nuclear speck ; nucleotide-activated protein kinase complex ; nucleus ; protein-containing complex ;  kinase activity ;  kinase activity ; AMP-activated protein kinase activity ; ATP binding ; chromatin binding ; eukaryotic elongation factor-2 kinase activator activity ; histone H2BS36 kinase activity ; histone serine kinase activity ; metal ion binding ; protein kinase activity ; protein serine kinase activity ; protein serine/threonine kinase activity ; protein-containing complex binding ; tau-protein kinase activity ; autophagy ; bile acid and bile salt transport ; bile acid signaling pathway ; CAMKK-AMPK signaling cascade ; cellular response to calcium ion ; cellular response to ethanol ; cellular response to glucose starvation ; cellular response to glucose stimulus ; cellular response to hydrogen peroxide ; cellular response to hypoxia ; cellular response to nutrient levels ; cellular response to organonitrogen compound ; cellular response to oxidative stress ; cellular response to prostaglandin E stimulus ; cellular response to xenobiotic stimulus ; cholesterol biosynthetic process ; chromatin organization ; cold acclimation ; energy homeostasis ; fatty acid biosynthetic process ; fatty acid homeostasis ; fatty acid oxidation ; glucose homeostasis ; glucose metabolic process ; intracellular signal transduction ; lipid biosynthetic process ; lipid droplet disassembly ; motor behavior ; negative regulation of apoptotic process ; negative regulation of gene expression ; negative regulation of hepatocyte apoptotic process ; negative regulation of insulin receptor signaling pathway ; negative regulation of lipid catabolic process ; negative regulation of TOR signaling ; negative regulation of translation ; negative regulation of tubulin deacetylation ; neuron cellular homeostasis ; positive regulation of adipose tissue development ; positive regulation of autophagy ; positive regulation of cell population proliferation ; positive regulation of DNA-templated transcription ; positive regulation of fatty acid oxidation ; positive regulation of gene expression ; positive regulation of gluconeogenesis ; positive regulation of glucose import ; positive regulation of glycolytic process ; positive regulation of mitochondrial transcription ; positive regulation of peptidyl-lysine acetylation ; positive regulation of protein localization ; positive regulation of protein targeting to mitochondrion ; positive regulation of skeletal muscle tissue development ; protein localization to lipid droplet ; protein phosphorylation ; regulation of bile acid secretion ; regulation of circadian rhythm ; regulation of gene expression ; regulation of microtubule cytoskeleton organization ; regulation of peptidyl-serine phosphorylation ; regulation of stress granule assembly ; regulation of vesicle-mediated transport ; response to activity ; response to caffeine ; response to camptothecin ; response to gamma radiation ; response to hydrogen peroxide ; response to UV ; response to xenobiotic stimulus ; rhythmic process ; Wnt signaling pathway


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: chromatin ; nucleoplasm ; nucleus ; transcription regulator complex ; bHLH transcription factor binding ; chromatin binding ; cis-regulatory region sequence-specific DNA binding ; DNA binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity, RNA polymerase II-specific ; metal ion binding ; nuclear estrogen receptor binding ; nuclear receptor binding ; promoter-specific chromatin binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; sequence-specific DNA binding ; sequence-specific double-stranded DNA binding ; transcription cis-regulatory region binding ; atrial septum morphogenesis ; axon regeneration ; axonogenesis ; canonical Wnt signaling pathway ; cardiac cell fate determination ; cardiac muscle cell myoblast differentiation ; cardiac right ventricle morphogenesis ; cell population proliferation ; cellular response to glucocorticoid stimulus ; endocardial cushion morphogenesis ; heart development ; heart morphogenesis ; innervation ; mesenchymal cell differentiation ; negative regulation of canonical Wnt signaling pathway ; negative regulation of DNA-templated transcription ; negative regulation of epithelial cell proliferation ; negative regulation of inflammatory response ; negative regulation of intracellular estrogen receptor signaling pathway ; negative regulation of neuron apoptotic process ; negative regulation of neuron differentiation ; negative regulation of protein-containing complex assembly ; negative regulation of transcription by RNA polymerase II ; neural crest cell migration ; neuron differentiation ; neuron fate commitment ; neuron fate specification ; outflow tract morphogenesis ; outflow tract septum morphogenesis ; pancreas development ; peripheral nervous system neuron axonogenesis ; peripheral nervous system neuron development ; pharyngeal system development ; pituitary gland development ; positive regulation of angiogenesis ; positive regulation of cell differentiation ; positive regulation of cell population proliferation ; positive regulation of DNA binding ; positive regulation of epithelial to mesenchymal transition ; positive regulation of granulocyte colony-stimulating factor production ; positive regulation of granulocyte macrophage colony-stimulating factor production ; positive regulation of insulin secretion ; positive regulation of interleukin-1 alpha production ; positive regulation of interleukin-1 beta production ; positive regulation of interleukin-12 production ; positive regulation of interleukin-6 production ; positive regulation of macrophage colony-stimulating factor production ; positive regulation of transcription by RNA polymerase II ; positive regulation of tumor necrosis factor production ; positive regulation of type II interferon production ; positive regulation of tyrosine phosphorylation of STAT protein ; positive regulation of vascular endothelial growth factor production ; regulation of DNA-templated transcription ; regulation of gene expression ; regulation of heart rate by cardiac conduction ; regulation of secondary heart field cardioblast proliferation ; retinal ganglion cell axon guidance ; secondary heart field specification ; sensory system development ; sinoatrial node cell development ; spinal cord motor neuron cell fate specification ; spinal cord motor neuron differentiation ; stem cell differentiation ; transcription by RNA polymerase II ; trigeminal nerve development ; ventricular cardiac muscle tissue morphogenesis ; visceral motor neuron differentiation


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: nuclear speck ; spliceosomal complex ; mRNA binding ; RNA binding ; mRNA splicing, via spliceosome ; RNA splicing


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: endoplasmic reticulum ; endoplasmic reticulum lumen ; endoplasmic reticulum membrane ; intracellular membrane-bounded organelle ; peroxisomal membrane ; peroxisome ; plasma membrane ; arachidonate-CoA ligase activity ; ATP binding ; cholate-CoA ligase activity ; enzyme binding ; fatty acid transmembrane transporter activity ; long-chain fatty acid transporter activity ; long-chain fatty acid-CoA ligase activity ; oleate transmembrane transporter activity ; phytanate-CoA ligase activity ; pristanate-CoA ligase activity ; very long-chain fatty acid-CoA ligase activity ; bile acid biosynthetic process ; carboxylic acid transmembrane transport ; fatty acid alpha-oxidation ; fatty acid beta-oxidation ; fatty acid transport ; long-chain fatty acid import into cell ; long-chain fatty acid metabolic process ; methyl-branched fatty acid metabolic process ; monocarboxylic acid transport ; very long-chain fatty acid catabolic process ; very long-chain fatty acid metabolic process


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: cell surface ; plasma membrane ; cell-cell adhesion mediator activity ; GTPase regulator activity ; protein antigen binding ; protein binding involved in heterotypic cell-cell adhesion ; protein phosphatase binding ; protein phosphorylated amino acid binding ; protein tyrosine kinase binding ; SH3 domain binding ; actin filament organization ; cell migration ; cell-matrix adhesion ; cellular response to hydrogen peroxide ; cellular response to interleukin-1 ; cellular response to interleukin-12 ; cellular response to lipopolysaccharide ; cellular response to type II interferon ; cytoskeleton organization ; granulocyte migration ; hematopoietic progenitor cell differentiation ; monocyte extravasation ; negative regulation of chemokine (C-C motif) ligand 5 production ; negative regulation of cytokine production involved in inflammatory response ; negative regulation of ERK1 and ERK2 cascade ; negative regulation of I-kappaB phosphorylation ; negative regulation of inflammatory response ; negative regulation of interferon-beta production ; negative regulation of interleukin-6 production ; negative regulation of JNK cascade ; negative regulation of macrophage inflammatory protein 1 alpha production ; negative regulation of nitric oxide biosynthetic process ; negative regulation of phagocytosis ; negative regulation of protein phosphorylation ; negative regulation of tumor necrosis factor production ; phagocytosis, engulfment ; phagocytosis, recognition ; positive regulation of phagocytosis ; positive regulation of T cell activation ; regulation of gene expression ; regulation of interleukin-1 beta production ; regulation of interleukin-6 production ; regulation of nitric oxide biosynthetic process ; regulation of tumor necrosis factor production ; regulation of type II interferon production


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytosol ; endoplasmic reticulum ; endoplasmic reticulum membrane ; aldehyde oxidase activity ; flavin adenine dinucleotide binding ; hypotaurine dehydrogenase activity ; monooxygenase activity ; N,N-dimethylaniline monooxygenase activity ; NADP binding ; NADPH oxidase H202-forming activity ; lipid metabolic process ; NADPH oxidation ; regulation of cholesterol metabolic process ; xenobiotic metabolic process


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: cytoplasm ; cytosol ; nucleus ; calcium ion binding ; enzyme regulator activity ; gluconolactonase activity ; zinc ion binding ; aging ; intracellular calcium ion homeostasis ; kidney development ; L-ascorbic acid biosynthetic process ; liver development ; liver regeneration ; negative regulation of apoptotic process ; negative regulation of bone development ; negative regulation of calcium-dependent ATPase activity ; negative regulation of cyclic-nucleotide phosphodiesterase activity ; negative regulation of DNA biosynthetic process ; negative regulation of DNA catabolic process ; negative regulation of epithelial cell proliferation ; negative regulation of flagellated sperm motility ; negative regulation of GTPase activity ; negative regulation of leucine-tRNA ligase activity ; negative regulation of nitric oxide biosynthetic process ; negative regulation of phosphoprotein phosphatase activity ; negative regulation of protein kinase activity ; negative regulation of protein phosphorylation ; negative regulation of RNA biosynthetic process ; positive regulation of ATP-dependent activity ; positive regulation of ATPase-coupled calcium transmembrane transporter activity ; positive regulation of dUTP diphosphatase activity ; positive regulation of fatty acid biosynthetic process ; positive regulation of glucose metabolic process ; positive regulation of GTPase activity ; positive regulation of phosphatase activity ; positive regulation of proteolysis involved in protein catabolic process ; positive regulation of superoxide dismutase activity ; positive regulation of triglyceride biosynthetic process ; regulation of calcium-mediated signaling ; spermatogenesis


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: membrane raft ; plasma membrane ; UTP:glucose-1-phosphate uridylyltransferase activity ; enterobacterial common antigen biosynthetic process ; UDP-glucose metabolic process


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: chloroplast ; chloroplast envelope ; chloroplast thylakoid ; plastid ; 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity ; divinyl chlorophyllide a 8-vinyl-reductase activity ; chlorophyll biosynthetic process


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: condensed nuclear chromosome ; germ cell nucleus ; nucleus ; DNA-binding transcription factor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; negative regulation of transcription by RNA polymerase II ; primary sex determination ; regulation of transcription by RNA polymerase II


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: cytoplasm ; mitochondrion ; nucleus ; plasma membrane ; BIR domain binding ; ubiquitin protein ligase binding ; antennal morphogenesis ; apoptotic process ; apoptotic signaling pathway ; cell death ; cellular response to gamma radiation ; cellular response to starvation ; dendrite morphogenesis ; ecdysone-mediated induction of salivary gland cell autophagic cell death ; entrainment of circadian clock by photoperiod ; head involution ; instar larval or pupal development ; intrinsic apoptotic signaling pathway in response to DNA damage ; larval midgut cell programmed cell death ; open tracheal system development ; positive regulation of apoptotic process ; positive regulation of apoptotic process involved in development ; positive regulation of cellular response to X-ray ; positive regulation of cysteine-type endopeptidase activity ; positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ; positive regulation of macroautophagy ; programmed cell death ; regulation of cysteine-type endopeptidase activity involved in apoptotic process ; regulation of organ growth ; response to red light ; salivary gland cell autophagic cell death ; sex differentiation


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: autophagosome ; cytoplasm ; cytosol ; membrane ; phagophore assembly site ; ATP binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; autophagosome assembly ; fibroblast activation ; late nucleophagy ; negative regulation of smoothened signaling pathway ; peptidyl-serine phosphorylation ; piecemeal microautophagy of the nucleus ; positive regulation of smoothened signaling pathway ; protein autophosphorylation ; regulation of autophagy ; reticulophagy ; smoothened signaling pathway


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cytoplasm ; mitochondrion ; cysteine synthase activity ; identical protein binding ; cysteine biosynthetic process from serine ; double fertilization forming a zygote and endosperm ; pollen tube growth


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Input: MTHLSLADPVREPLFSGEAGRQTAMAKDILAEAGLHFDELNKLRVLDPEVSQQTIELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKMQLERYRVEYEALCKVEAEQNEFIDQFIFQK

Output: acrosomal vesicle ; centriole ; centrosome ; ciliary base ; cilium ; cis-Golgi network ; cytoplasm ; dendrite terminus ; Golgi apparatus ; intraciliary transport particle B ; kinociliary basal body ; manchette ; microvillus ; motile cilium ; photoreceptor connecting cilium ; photoreceptor outer segment ; stereocilium ; opsin binding ; small GTPase binding ; cardiac muscle cell differentiation ; centrosome localization ; cilium assembly ; cochlea development ; establishment of epithelial cell apical/basal polarity ; establishment of planar polarity ; inner ear receptor cell stereocilium organization ; intraciliary transport ; kidney development ; neural precursor cell proliferation ; opsin transport ; photoreceptor cell outer segment organization ; positive regulation of cilium assembly ; protein localization to cilium ; protein localization to Golgi apparatus ; protein localization to plasma membrane ; regulation of autophagosome assembly ; regulation of canonical Wnt signaling pathway ; regulation of cilium assembly ; regulation of platelet-derived growth factor receptor-alpha signaling pathway ; smoothened signaling pathway ; spermatogenesis ; visual learning


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: cytoplasm ; microtubule ; mitochondrial inner membrane ; mitochondrial intermembrane space ; mitochondrial membrane ; cardiolipin binding ; GTP binding ; GTPase activity ; microtubule binding ; phosphatidic acid binding ; apoptotic process ; chordate embryonic development ; GTP metabolic process ; membrane tubulation ; mitochondrial fusion ; mitochondrion morphogenesis ; ventricular cardiac muscle cell development


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: cell periphery ; membrane ; membrane raft ; nuclear membrane ; T-tubule ; endothelin receptor activity ; G protein-coupled receptor activity ; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ; angiogenesis ; aorta development ; artery smooth muscle contraction ; atrial cardiac muscle tissue development ; axon extension ; axon guidance ; axonogenesis involved in innervation ; blood vessel remodeling ; branching involved in blood vessel morphogenesis ; calcium ion transmembrane transport ; canonical Wnt signaling pathway ; cardiac chamber formation ; cardiac neural crest cell migration involved in outflow tract morphogenesis ; cellular response to follicle-stimulating hormone stimulus ; cellular response to human chorionic gonadotropin stimulus ; cellular response to hydrogen peroxide ; cellular response to luteinizing hormone stimulus ; cellular response to mechanical stimulus ; cellular response to organic substance ; cellular response to oxidative stress ; cranial skeletal system development ; embryonic heart tube development ; embryonic skeletal system development ; endothelin receptor signaling pathway ; endothelin receptor signaling pathway involved in heart process ; enteric nervous system development ; establishment of endothelial barrier ; face development ; fibroblast proliferation ; G protein-coupled receptor signaling pathway ; gene expression ; glomerular endothelium development ; glomerular filtration ; glomerulus development ; head development ; heart development ; heparin metabolic process ; histamine secretion ; I-kappaB kinase/NF-kappaB signaling ; in utero embryonic development ; intracellular calcium ion homeostasis ; left ventricular cardiac muscle tissue morphogenesis ; meiotic cell cycle process involved in oocyte maturation ; mesenchymal cell apoptotic process ; middle ear morphogenesis ; mitochondrion organization ; mitotic cell cycle ; multicellular organism aging ; negative regulation of apoptotic process ; neural crest cell development ; neural crest cell differentiation ; neural crest cell fate commitment ; neuromuscular process ; neuron projection development ; neuron remodeling ; noradrenergic neuron differentiation ; norepinephrine metabolic process ; penile erection ; pharyngeal arch artery morphogenesis ; podocyte apoptotic process ; podocyte differentiation ; positive regulation of calcium ion transport ; positive regulation of cation channel activity ; positive regulation of cell population proliferation ; positive regulation of cytosolic calcium ion concentration ; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ; positive regulation of ERK1 and ERK2 cascade ; positive regulation of inflammatory response ; positive regulation of kidney development ; positive regulation of neutrophil chemotaxis ; positive regulation of odontogenesis ; positive regulation of protein phosphorylation ; positive regulation of release of sequestered calcium ion into cytosol ; protein kinase A signaling ; protein kinase C-activating G protein-coupled receptor signaling pathway ; protein phosphorylation ; protein transmembrane transport ; regulation of blood pressure ; regulation of epithelial cell proliferation ; regulation of glucose transmembrane transport ; regulation of heart rate ; regulation of protein localization to cell leading edge ; renal albumin absorption ; renal sodium ion absorption ; respiratory gaseous exchange by respiratory system ; response to acetylcholine ; response to amphetamine ; response to hypoxia ; response to lipopolysaccharide ; response to morphine ; response to organic substance ; response to wounding ; Rho protein signal transduction ; semaphorin-plexin signaling pathway involved in axon guidance ; sensory perception of pain ; smooth muscle cell proliferation ; sodium ion homeostasis ; specification of segmental identity, mandibular segment ; specification of segmental identity, maxillary segment ; sympathetic nervous system development ; sympathetic neuron axon guidance ; thyroid gland development ; vascular associated smooth muscle cell development ; vasoconstriction


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: extracellular region ; plant-type cell wall ; heme binding ; lactoperoxidase activity ; metal ion binding ; peroxidase activity ; hydrogen peroxide catabolic process ; lignin metabolic process ; plant-type cell wall organization ; response to oxidative stress


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytoplasm ; nucleolus ; nucleoplasm ; nucleus ; histone demethylase activity ; histone H3R2 demethylase activity ; histone H3R3 demethylase activity ; metal ion binding ; P-TEFb complex binding ; peptidyl-lysine 5-dioxygenase activity ; single-stranded RNA binding ; cell differentiation ; chromatin organization ; mRNA processing ; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine ; phagocytosis ; protein homooligomerization ; regulation of mRNA splicing, via spliceosome ; RNA splicing ; sprouting angiogenesis


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: membrane ; mitochondrial inner membrane ; mitochondrial outer membrane ; mitochondrion ; membrane insertase activity ; cellular response to radiation ; establishment of protein localization to mitochondrial membrane involved in mitochondrial fission ; hematopoietic stem cell homeostasis ; hematopoietic stem cell migration ; hepatocyte apoptotic process ; lactate metabolic process ; lipid homeostasis ; mitochondrial ATP synthesis coupled electron transport ; negative regulation of glycolytic process ; negative regulation of mitochondrial membrane potential ; positive regulation of apoptotic process ; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ; positive regulation of stem cell differentiation ; protein insertion into mitochondrial outer membrane ; protein localization to mitochondrion ; regulation of mitochondrial fusion ; regulation of mitochondrial membrane permeability involved in apoptotic process


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; nucleus ; mRNA binding ; RNA binding ; heart process ; mRNA processing ; nervous system development ; regulation of alternative mRNA splicing, via spliceosome ; regulation of RNA splicing ; RNA splicing ; skeletal muscle fiber development


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: apoplast ; copper ion binding ; hydroquinone:oxygen oxidoreductase activity ; oxidoreductase activity ; flavonoid biosynthetic process ; lignin biosynthetic process ; lignin catabolic process ; proanthocyanidin biosynthetic process ; response to copper ion


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: membrane ; mitochondrial inner membrane ; mitochondrion ; ATP transmembrane transporter activity ; ATP:inorganic phosphate antiporter activity ; calcium ion binding ; ion binding ; adenine nucleotide transport ; ADP transport ; ATP transport ; cellular response to calcium ion ; cellular response to oxidative stress ; mitochondrial transport ; regulation of cell death


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; nucleus ; ATP binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; protein tyrosine kinase activity ; autophagosome assembly ; determination of adult lifespan ; peptidyl-serine phosphorylation ; peptidyl-threonine phosphorylation ; response to heat ; response to oxidative stress


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Input: MNPRKKVDLKLIIVGALGVGKTSLLHQYVHKTFFEEYQTTLGASILSKIIILDDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDPESFEALDIWRDDVLAKIIPMEQSYPMVVLGNKIDLEDRKVSQEVVHGWCKEKDMPYFEVSAKNDINVVQAFEVLASRALLRYQGTAENHLIDSIKLSPGQPKSRCC

Output: Golgi apparatus ; late endosome ; lysosome ; phagocytic vesicle ; phagocytic vesicle membrane ; trans-Golgi network ; GTP binding ; GTPase activity ; cellular response to type II interferon ; endosome to lysosome transport ; late endosome to Golgi transport ; negative regulation of toll-like receptor 4 signaling pathway ; negative regulation of toll-like receptor 9 signaling pathway ; phagosome-lysosome fusion ; positive regulation of interleukin-6 production ; positive regulation of megakaryocyte differentiation ; positive regulation of NF-kappaB transcription factor activity ; protein transport


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytoplasm ; female germ cell nucleus ; nucleosome ; nucleus ; DNA binding ; double-stranded DNA binding ; nucleosomal DNA binding ; structural constituent of chromatin ; chromosome condensation ; epigenetic regulation of gene expression ; meiotic cell cycle ; negative regulation of DNA recombination ; nucleosome assembly


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: chloroplast ; chloroplast envelope ; cytoplasm ; plasma membrane ; plastid ; 3-chloroallyl aldehyde dehydrogenase activity ; aldehyde dehydrogenase (NAD+) activity ; aldehyde dehydrogenase (NADP+) activity ; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity ; cellular aldehyde metabolic process ; response to abscisic acid ; response to water deprivation


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: MutLalpha complex ; nucleus ; ATP binding ; ATP hydrolysis activity ; ATP-dependent DNA damage sensor activity ; mismatched DNA binding ; DNA recombination ; fruit development ; mismatch repair ; pollen development ; seed development


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytoplasm ; mitochondrial respiratory chain complex I ; mitochondrion ; plastid ; cobalt ion binding ; glycine hydroxymethyltransferase activity ; pyridoxal phosphate binding ; serine binding ; zinc ion binding ; folic acid metabolic process ; glycine biosynthetic process from serine ; glycine metabolic process ; L-serine catabolic process ; L-serine metabolic process ; one-carbon metabolic process ; tetrahydrofolate interconversion ; tetrahydrofolate metabolic process


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: protein storage vacuole ; nutrient reservoir activity ; cellular response to abscisic acid stimulus ; response to abscisic acid ; seed maturation


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cytosol ; peroxisomal membrane ; peroxisome ; plasmodesma ; ubiquitin-protein transferase activity ; zinc ion binding ; fatty acid beta-oxidation ; peroxisome organization ; photomorphogenesis ; protein import into peroxisome matrix ; protein monoubiquitination


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: cytoplasm ; endoplasmic reticulum ; lipid droplet ; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity ; estradiol 17-beta-dehydrogenase  activity ; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ; steroid dehydrogenase activity ; androgen catabolic process ; steroid biosynthetic process


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: Golgi apparatus ; Golgi membrane ; acetyltransferase activity ; oxidoreductase activity ; plant-type secondary cell wall biogenesis ; xylan acetylation ; xylan biosynthetic process ; xylan metabolic process ; xyloglucan metabolic process


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: membrane ; (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity ; 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity ; DMNT synthase activity ; heme binding ; iron ion binding ; monooxygenase activity ; defense response to fungus ; defense response to insect ; negative regulation of oviposition ; response to bacterium ; terpene biosynthetic process ; terpenoid biosynthetic process


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: apical plasma membrane ; basolateral plasma membrane ; organic anion transmembrane transporter activity ; prostaglandin transmembrane transporter activity ; protein kinase C binding ; quaternary ammonium group transmembrane transporter activity ; solute:inorganic anion antiporter activity ; glutathione transport ; monoatomic ion transport ; prostaglandin transport ; quaternary ammonium group transport ; response to organic cyclic compound ; response to toxic substance


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: chloroplast ; chloroplast thylakoid lumen ; chloroplast thylakoid membrane ; cytosol ; thylakoid lumen ; nutrient reservoir activity ; small molecule binding ; lipid metabolic process ; negative regulation of fatty acid oxidation ; photoprotection ; response to abscisic acid ; response to heat ; response to high light intensity ; response to oxidative stress ; response to paraquat ; response to water deprivation ; seed maturation


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: cytoplasm ; glutathione dehydrogenase (ascorbate) activity ; glutathione transferase activity ; protein homodimerization activity ; pyrimidodiazepine synthase activity ; eye pigment biosynthetic process ; glutathione metabolic process ; pteridine biosynthetic process


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: centriole ; ciliary cap ; ciliary transition zone ; cytoplasm ; MKS complex ; axoneme assembly ; ciliary transition zone assembly ; cilium assembly ; non-motile cilium assembly


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: Cajal body ; Cul2-RING ubiquitin ligase complex ; Cul3-RING ubiquitin ligase complex ; Cul4A-RING E3 ubiquitin ligase complex ; cytoplasm ; Lewy body ; nuclear body ; nucleoplasm ; nucleus ; SCF ubiquitin ligase complex ; ubiquitin ligase complex ; ubiquitin conjugating enzyme binding ; ubiquitin protein ligase activity ; ubiquitin protein ligase binding ; ubiquitin-protein transferase activity ; zinc ion binding ; positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; protein polyubiquitination ; protein ubiquitination ; ubiquitin-dependent protein catabolic process


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Input: MAVNDCFSLTYPHNPHPGDLIEVFRPCYQHWALYLGDGYVINIAPVDGIPSSFSSAKSVFSTKALVKMQLLKDVVGNDTYRINNKYDTTYPPLPVEEVIQRSEFAIGQEVTYDLLVNNCEHFVTLLRYGEGVSEQANRAIGTIGLVAAGIDIFTFLGLFPKRQGAKS

Output: cytoplasm ; cytosol ; endoplasmic reticulum ; lysosome ; membrane ; mitochondrion ; nuclear envelope lumen ; nucleus ; peroxisome ; 1-acyl-2-lysophosphatidylserine acylhydrolase activity ; N-acyltransferase activity ; O-acyltransferase activity ; phosphatidylserine 1-acylhydrolase activity ; phospholipase A1 activity ; phospholipase A2 activity ; phospholipase activity ; ether lipid metabolic process ; lens fiber cell differentiation ; lipid catabolic process ; N-acylphosphatidylethanolamine metabolic process ; organelle disassembly ; peroxisome organization ; phosphatidylcholine metabolic process


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: nucleus ; transcription regulator complex ; DNA-binding transcription factor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; sequence-specific DNA binding ; determination of adult lifespan ; positive regulation of gene expression ; positive regulation of RNA splicing ; regulation of cell cycle ; regulation of cell population proliferation ; regulation of transcription by RNA polymerase II ; response to starvation ; response to toxic substance


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: NAD binding ; phosphoglycerate dehydrogenase activity ; G1 to G0 transition ; gamma-aminobutyric acid metabolic process ; glial cell development ; glutamine metabolic process ; glycine metabolic process ; L-serine biosynthetic process ; L-serine metabolic process ; neural tube development ; neurogenesis ; neuron projection development ; regulation of gene expression ; serine family amino acid biosynthetic process ; spinal cord development ; taurine metabolic process ; threonine metabolic process


Instruction: Predict the GO term based on the protein sequence.

Output: cytoplasm ; nucleoplasm ; nucleus ; transcription regulator complex ; C2H2 zinc finger domain binding ; chromatin binding ; DNA binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; sequence-specific DNA binding ; sequence-specific double-stranded DNA binding ; transcription coactivator binding ; transcription coregulator binding ; zinc ion binding ; angiogenesis ; brown fat cell differentiation ; cell differentiation in hindbrain ; cell fate commitment ; cell fate determination ; central nervous system neuron development ; cochlea development ; commitment of neuronal cell to specific neuron type in forebrain ; definitive hemopoiesis ; embryonic placenta development ; eosinophil fate commitment ; GABAergic neuron differentiation ; glandular epithelial cell differentiation ; glandular epithelial cell maturation ; hematopoietic progenitor cell differentiation ; hematopoietic stem cell homeostasis ; homeostasis of number of cells within a tissue ; inner ear morphogenesis ; myeloid cell differentiation ; negative regulation of brown fat cell differentiation ; negative regulation of endothelial cell apoptotic process ; negative regulation of fat cell differentiation ; negative regulation of fat cell proliferation ; negative regulation of gene expression ; negative regulation of hematopoietic progenitor cell differentiation ; negative regulation of macrophage differentiation ; negative regulation of myeloid cell differentiation ; negative regulation of neural precursor cell proliferation ; negative regulation of neuroblast proliferation ; negative regulation of Notch signaling pathway ; negative regulation of transcription by RNA polymerase II ; neural precursor cell proliferation ; neuroblast proliferation ; neuroendocrine cell differentiation ; neuron differentiation ; neuron fate commitment ; neuron migration ; phagocytosis ; pituitary gland development ; positive regulation of angiogenesis ; positive regulation of blood vessel endothelial cell migration ; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ; positive regulation of cell migration involved in sprouting angiogenesis ; positive regulation of cytosolic calcium ion concentration ; positive regulation of erythrocyte differentiation ; positive regulation of gene expression ; positive regulation of mast cell degranulation ; positive regulation of megakaryocyte differentiation ; positive regulation of miRNA transcription ; positive regulation of neuron differentiation ; positive regulation of phagocytosis ; positive regulation of phagocytosis, engulfment ; positive regulation of transcription by RNA polymerase II ; regulation of forebrain neuron differentiation ; regulation of histone acetylation ; regulation of primitive erythrocyte differentiation ; response to lipid ; semicircular canal development ; somatic stem cell population maintenance ; thyroid-stimulating hormone-secreting cell differentiation ; transcription by RNA polymerase II ; urogenital system development ; vascular wound healing ; ventral spinal cord interneuron differentiation


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: autophagosome ; cytoplasm ; cytosol ; nucleus ; ribonucleoprotein complex ; ribosome ; protein kinase C binding ; protein-macromolecule adaptor activity ; ribosome binding ; translation regulator activity ; cellular response to starvation ; cuticle development ; IRES-dependent viral translational initiation ; locomotory behavior ; muscle cell cellular homeostasis ; negative regulation of protein phosphorylation ; negative regulation of smoothened signaling pathway ; oogenesis ; oviposition ; positive regulation by host of viral genome replication ; positive regulation of actin filament polymerization ; positive regulation of glycogen biosynthetic process ; positive regulation of protein deubiquitination ; positive regulation of protein phosphorylation ; positive regulation of protein ubiquitination ; regulation of autophagosome size ; rescue of stalled ribosome ; wing disc development


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: extracellular space ; glutamatergic synapse ; plasma membrane ; synapse ; chemorepellent activity ; growth factor activity ; receptor ligand activity ; animal organ development ; chemorepulsion involved in interneuron migration from the subpallium to the cortex ; ERBB4 signaling pathway ; ERBB4-ERBB4 signaling pathway ; intracellular signal transduction ; mammary gland development ; mammary placode formation ; modulation of chemical synaptic transmission ; negative regulation of neuron migration ; pattern specification process ; synapse assembly


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cytosol ; type I site-specific deoxyribonuclease complex ; ATP binding ; DNA binding ; helicase activity ; type I site-specific deoxyribonuclease activity ; DNA restriction-modification system


Instruction: Predict the GO term based on the protein sequence.

Output: carbohydrate derivative binding ; glutamine-fructose-6-phosphate transaminase (isomerizing) activity ; fructose 6-phosphate metabolic process ; fungal-type cell wall chitin biosynthetic process ; glutamine metabolic process ; protein N-linked glycosylation ; UDP-N-acetylglucosamine biosynthetic process ; UDP-N-acetylglucosamine metabolic process


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cell periphery ; extracellular space ; perinuclear region of cytoplasm ; cytokine activity ; growth factor activity ; hormone activity ; protein homodimerization activity ; activin receptor signaling pathway ; apoptotic signaling pathway ; BMP signaling pathway ; cellular response to calcium ion ; cellular response to cAMP ; cellular response to cholesterol ; cellular response to insulin stimulus ; cellular response to interleukin-1 ; cellular response to leptin stimulus ; cellular response to organic cyclic compound ; cellular response to starvation ; cellular response to Thyroglobulin triiodothyronine ; cellular response to thyroid hormone stimulus ; fat cell differentiation ; female gonad development ; male gonad development ; multicellular organism aging ; negative regulation of follicle-stimulating hormone secretion ; negative regulation of hepatocyte growth factor production ; negative regulation of insulin secretion ; oocyte development ; pituitary gland development ; positive regulation of apoptotic signaling pathway ; positive regulation of follicle-stimulating hormone secretion ; positive regulation of ovulation ; positive regulation of pathway-restricted SMAD protein phosphorylation ; response to gonadotropin ; response to insecticide ; response to organic cyclic compound ; response to wounding ; seminiferous tubule development ; SMAD protein signal transduction ; spermatogenesis


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: mitochondrial inner membrane ; mitochondrion ; acyltransferase activity ; carnitine O-octanoyltransferase activity ; carnitine O-palmitoyltransferase activity ; carnitine metabolic process ; fatty acid beta-oxidation ; in utero embryonic development ; long-chain fatty acid metabolic process ; long-chain fatty acid transport ; positive regulation of cold-induced thermogenesis ; response to fatty acid


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytoplasm ; mitochondrion ; glycine hydroxymethyltransferase activity ; pyridoxal phosphate binding ; serine binding ; zinc ion binding ; folic acid metabolic process ; glycine biosynthetic process from serine ; L-serine catabolic process ; one-carbon metabolic process ; tetrahydrofolate interconversion ; tetrahydrofolate metabolic process


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: mitochondrial inner membrane ; mitochondrial matrix ; mitochondrion ; ATP binding ; ATP hydrolysis activity ; positive regulation of protein-pyridoxal-5-phosphate linkage ; protein import into mitochondrial matrix ; protein refolding ; proteolysis involved in protein catabolic process


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytosol ; alcohol dehydrogenase (NAD+) activity ; alcohol dehydrogenase activity, zinc-dependent ; aldehyde oxidase activity ; ethanol binding ; identical protein binding ; NAD binding ; NAD-retinol dehydrogenase activity ; omega-hydroxydecanoate dehydrogenase activity ; receptor antagonist activity ; retinol binding ; zinc ion binding ; ethanol catabolic process ; ethanol metabolic process ; ethanol oxidation ; fatty acid omega-oxidation ; response to bacterium ; response to ethanol ; retinoic acid metabolic process ; retinoid metabolic process ; retinol metabolic process


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: cytoplasm ; Mre11 complex ; nucleoplasm ; nucleus ; DNA endonuclease activity ; double-stranded DNA binding ; identical protein binding ; single-stranded DNA endodeoxyribonuclease activity ; DNA double-strand break processing ; DNA double-strand break processing involved in repair via synthesis-dependent strand annealing ; gene conversion at mating-type locus ; meiotic DNA double-strand break formation ; meiotic DNA double-strand break processing ; positive regulation of dephosphorylation ; positive regulation of exonuclease activity ; telomere maintenance ; telomeric 3' overhang formation


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: acrosomal vesicle ; external side of plasma membrane ; membrane raft ; plasma membrane ; hyalurononglucosaminidase activity ; carbohydrate metabolic process ; cell adhesion ; fusion of sperm to egg plasma membrane involved in single fertilization ; hyaluronan catabolic process ; single fertilization


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: endoplasmic reticulum membrane ; photoreceptor outer segment ; photoreceptor outer segment membrane ; plasma membrane ; ATP binding ; GTP binding ; guanylate cyclase activity ; identical protein binding ; peptide receptor activity ; protein homodimerization activity ; protein kinase activity ; protein-containing complex binding ; cGMP biosynthetic process ; cGMP-mediated signaling ; protein phosphorylation ; receptor guanylyl cyclase signaling pathway ; visual perception


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytoplasm ; membrane ; nucleus ; plasma membrane ; cholecystokinin receptor activity ; gastrin receptor activity ; peptide hormone binding ; type B gastrin/cholecystokinin receptor binding ; apoptotic process ; behavioral defense response ; cholecystokinin signaling pathway ; digestive tract development ; ERK1 and ERK2 cascade ; estrous cycle ; gastric acid secretion ; gland development ; histamine secretion ; pH reduction ; phospholipase C-activating G protein-coupled receptor signaling pathway ; positive regulation of behavioral fear response ; positive regulation of cell population proliferation ; positive regulation of cytosolic calcium ion concentration ; positive regulation of somatostatin secretion ; positive regulation of synaptic transmission ; positive regulation of synaptic transmission, GABAergic ; positive regulation of synaptic transmission, glutamatergic ; regulation of sensory perception of pain


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Input: MFGLPQQEVSEEEKRAHQEQTEKTLKQAAYVAAFLWVSPMIWHLVKKQWK

Output: mitochondrial outer membrane ; mitochondrial outer membrane translocase complex ; mitochondrion ; mitochondrial outer membrane translocase complex assembly ; protein insertion into mitochondrial outer membrane ; protein targeting to mitochondrion ; protein transmembrane transport


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Input: MRTLSLLTLLALAALCLSDLTDAKPSGPESDKAFMSKQEGNKVVNRLRRYLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYKRIYGITI

Output: cell projection ; cytoplasm ; dendrite ; extracellular region ; extracellular space ; Golgi apparatus ; perikaryon ; rough endoplasmic reticulum ; vesicle ; calcium ion binding ; hydroxyapatite binding ; structural constituent of bone ; biomineral tissue development ; bone development ; cellular lipid catabolic process ; cellular response to insulin stimulus ; dephosphorylation ; glucose homeostasis ; osteoblast differentiation ; pancreas development ; positive regulation of insulin secretion ; regulation of bone mineralization ; regulation of cellular response to insulin stimulus ; response to vitamin K ; type B pancreatic cell proliferation


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: basement membrane ; collagen-containing extracellular matrix ; extracellular region ; neuromuscular junction ; synaptic cleft ; signaling receptor binding ; blood vessel development ; brown fat cell differentiation ; cell adhesion ; negative regulation of cold-induced thermogenesis ; regulation of cell adhesion ; regulation of cell migration ; regulation of embryonic development


Instruction: Predict the GO term based on the protein sequence.

Output: ubiquitin ligase complex ; protein-folding chaperone binding ; protein-macromolecule adaptor activity ; cell cycle ; kinetochore assembly ; protein-containing complex assembly


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Input: MADQTASAEVATEKMDTAEAPAAAPAASAAAPAEAESNENTTVPSNVLSANGGQQTGNQSAPRNTSTVPTRQYLDSTVVPILLQGLGALAKDRPENPIEFLANFLLREKDRYNAENQNPAGQQ

Output: nucleus ; Set1C/COMPASS complex ; dosage compensation by hypoactivation of X chromosome ; locomotion ; nematode male tail tip morphogenesis ; regulation of multicellular organism growth ; transdifferentiation


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: chloroplast ; cytosol ; mitochondrion ; ATP binding ; guanylate kinase activity ; phosphorylation ; regulation of developmental growth


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: chromosome, telomeric region ; cytoplasm ; Elg1 RFC-like complex ; mitochondrion ; nucleus ; chromatin binding ; DNA binding ; DNA clamp unloading ; DNA-templated DNA replication ; double-strand break repair via homologous recombination ; mitotic sister chromatid cohesion ; negative regulation of transposition, RNA-mediated


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cell periphery ; cytoplasm ; eisosome ; eisosome filament ; mitochondrial outer membrane ; mitochondrion ; plasma membrane ; lipid binding ; eisosome assembly ; endocytosis ; negative regulation of protein kinase activity ; response to heat


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: cilium ; cytoplasmic microtubule ; dendrite ; neuronal cell body ; perikaryon ; microtubule binding ; axoneme assembly ; chemotaxis ; hyperosmotic response ; microtubule cytoskeleton organization ; non-motile cilium assembly ; sensory perception


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: plasma membrane ; receptor complex ; ATP binding ; transmembrane receptor protein tyrosine kinase activity ; nematode male tail tip morphogenesis ; positive regulation of kinase activity ; protein phosphorylation ; transmembrane receptor protein tyrosine kinase signaling pathway


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: commitment complex ; nuclear speck ; nucleoplasm ; nucleus ; precatalytic spliceosome ; spliceosomal complex ; U2-type prespliceosome ; U2AF complex ; mRNA binding ; poly-pyrimidine tract binding ; pre-mRNA 3'-splice site binding ; RNA binding ; mRNA splicing, via spliceosome ; nuclear export ; positive regulation of RNA export from nucleus ; regulation of alternative mRNA splicing, via spliceosome ; RNA splicing


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: membrane ; postsynaptic density ; ruffle membrane ; guanyl-nucleotide exchange factor activity ; ARF protein signal transduction ; regulation of ARF protein signal transduction


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: endoplasmic reticulum ; Golgi apparatus ; Golgi membrane ; postsynapse ; postsynaptic density ; palmitoyltransferase activity ; protein-cysteine S-myristoyltransferase activity ; protein-cysteine S-palmitoyltransferase activity ; protein-cysteine S-stearoyltransferase activity ; zinc ion binding ; establishment of protein localization ; peptidyl-L-cysteine S-palmitoylation ; positive regulation of dendrite development ; protein localization to membrane ; protein localization to postsynapse ; protein palmitoylation ; protein targeting to Golgi apparatus ; protein targeting to membrane ; regulation of dendritic spine morphogenesis ; synaptic vesicle maturation


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: mitochondrion ; zinc ion binding ; negative regulation of innate immune response


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: NuA4 histone acetyltransferase complex ; nucleosome ; Piccolo NuA4 histone acetyltransferase complex ; Swr1 complex ; histone H2A acetyltransferase activity ; histone H4K12 acetyltransferase activity ; histone H4K16 acetyltransferase activity ; histone H4K5 acetyltransferase activity ; histone H4K8 acetyltransferase activity ; metal ion binding ; methylated histone binding ; chromatin organization ; histone acetylation ; histone H2A acetylation ; histone H4 acetylation ; positive regulation of apoptotic process ; positive regulation of double-strand break repair via homologous recombination ; regulation of cell cycle ; regulation of DNA-templated transcription


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; cinnamate beta-D-glucosyltransferase activity ; hydroxycinnamate 4-beta-glucosyltransferase activity ; sinapate 1-glucosyltransferase activity ; UDP-glucosyltransferase activity ; response to toxic substance ; response to UV-B


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: endoplasmic reticulum membrane ; extracellular region ; Golgi membrane ; plasma membrane ; calcium ion binding ; cholesterol-protein transferase activity ; patched binding ; peptidase activity ; zinc ion binding ; cell fate specification ; cell-cell signaling ; intein-mediated protein splicing ; Leydig cell differentiation ; male gonad development ; male sex determination ; myelination ; osteoblast differentiation ; paracrine signaling ; positive regulation of smoothened signaling pathway ; protein autoprocessing ; regulation of steroid biosynthetic process ; response to estradiol ; response to estrogen ; Schwann cell development ; self proteolysis ; smoothened signaling pathway ; spermatid development ; spermatogenesis


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: Golgi membrane ; postsynaptic density ; synapse ; GTPase activator activity ; metal ion binding ; protein transport ; regulation of ARF protein signal transduction ; regulation of endocytosis ; vesicle-mediated transport


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytosol ; extracellular region ; extracellular space ; lysosome ; secretory granule ; vesicle ; cytokine activity ; integrin binding ; interleukin-1 receptor binding ; protein domain specific binding ; acute inflammatory response ; astrocyte activation ; cellular response to antibiotic ; cellular response to fatty acid ; cellular response to glucose stimulus ; cellular response to interleukin-17 ; cellular response to lipid ; cellular response to lipopolysaccharide ; cellular response to mechanical stimulus ; cellular response to organic cyclic compound ; cellular response to organic substance ; cellular response to xenobiotic stimulus ; chronic inflammatory response to antigenic stimulus ; cytokine-mediated signaling pathway ; defense response to Gram-positive bacterium ; ectopic germ cell programmed cell death ; extrinsic apoptotic signaling pathway in absence of ligand ; fever generation ; hyaluronan biosynthetic process ; I-kappaB kinase/NF-kappaB signaling ; inflammatory response ; interleukin-1-mediated signaling pathway ; JNK cascade ; learning or memory ; leukocyte migration ; lipopolysaccharide-mediated signaling pathway ; MAPK cascade ; memory ; monocyte aggregation ; negative regulation of adiponectin secretion ; negative regulation of branching morphogenesis of a nerve ; negative regulation of cell population proliferation ; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ; negative regulation of gap junction assembly ; negative regulation of gene expression ; negative regulation of glucose transmembrane transport ; negative regulation of glutamate secretion ; negative regulation of insulin receptor signaling pathway ; negative regulation of lipid catabolic process ; negative regulation of lipid metabolic process ; negative regulation of MAP kinase activity ; negative regulation of neural precursor cell proliferation ; negative regulation of neurogenesis ; negative regulation of neuron differentiation ; negative regulation of synaptic transmission ; negative regulation of transcription by RNA polymerase II ; neutrophil chemotaxis ; ovulation ; positive regulation of angiogenesis ; positive regulation of apoptotic process ; positive regulation of astrocyte differentiation ; positive regulation of calcidiol 1-monooxygenase activity ; positive regulation of cell death ; positive regulation of cell division ; positive regulation of cell migration ; positive regulation of cell population proliferation ; positive regulation of chemokine production ; positive regulation of complement activation ; positive regulation of cytosolic calcium ion concentration ; positive regulation of DNA-binding transcription factor activity ; positive regulation of DNA-templated transcription ; positive regulation of epithelial to mesenchymal transition ; positive regulation of ERK1 and ERK2 cascade ; positive regulation of fever generation ; positive regulation of gene expression ; positive regulation of glial cell differentiation ; positive regulation of glial cell proliferation ; positive regulation of granulocyte macrophage colony-stimulating factor production ; positive regulation of heterotypic cell-cell adhesion ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of immature T cell proliferation in thymus ; positive regulation of inflammatory response ; positive regulation of interleukin-2 production ; positive regulation of interleukin-6 production ; positive regulation of interleukin-8 production ; positive regulation of JNK cascade ; positive regulation of JUN kinase activity ; positive regulation of lipid catabolic process ; positive regulation of MAP kinase activity ; positive regulation of membrane protein ectodomain proteolysis ; positive regulation of mitotic nuclear division ; positive regulation of monocyte chemotactic protein-1 production ; positive regulation of myosin light chain kinase activity ; positive regulation of neuron apoptotic process ; positive regulation of neutrophil chemotaxis ; positive regulation of NF-kappaB transcription factor activity ; positive regulation of NIK/NF-kappaB signaling ; positive regulation of nitric oxide biosynthetic process ; positive regulation of p38MAPK cascade ; positive regulation of phagocytosis ; positive regulation of prostaglandin biosynthetic process ; positive regulation of prostaglandin secretion ; positive regulation of protein phosphorylation ; positive regulation of RNA biosynthetic process ; positive regulation of stress-activated MAPK cascade ; positive regulation of T cell proliferation ; positive regulation of T-helper 1 cell cytokine production ; positive regulation of transcription by RNA polymerase II ; positive regulation of type II interferon production ; positive regulation of vascular endothelial growth factor production ; protein kinase B signaling ; regulation of defense response to virus by host ; regulation of ERK1 and ERK2 cascade ; regulation of establishment of endothelial barrier ; regulation of I-kappaB kinase/NF-kappaB signaling ; regulation of insulin secretion ; regulation of neurogenesis ; regulation of nitric-oxide synthase activity ; response to ATP ; response to carbohydrate ; response to dexamethasone ; response to estradiol ; response to ethanol ; response to gamma radiation ; response to glucocorticoid ; response to heat ; response to hypoxia ; response to immobilization stress ; response to interleukin-1 ; response to isolation stress ; response to L-ascorbic acid ; response to lipopolysaccharide ; response to morphine ; response to nutrient ; response to organic cyclic compound ; response to organonitrogen compound ; response to ozone ; response to peptide hormone ; response to stilbenoid ; response to vitamin D ; response to xenobiotic stimulus ; sequestering of triglyceride ; social behavior ; vascular endothelial growth factor production ; wound healing


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: dendrite ; dendritic spine ; glutamatergic synapse ; Golgi apparatus ; intercalated disc ; membrane ; neuronal cell body ; plasma membrane ; postsynaptic membrane ; rough endoplasmic reticulum ; smooth endoplasmic reticulum ; T-tubule ; voltage-gated potassium channel complex ; identical protein binding ; inward rectifier potassium channel activity ; phosphatidylinositol-4,5-bisphosphate binding ; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization ; cardiac muscle cell action potential ; cardiac muscle cell action potential involved in contraction ; cellular response to mechanical stimulus ; magnesium ion transport ; membrane repolarization during action potential ; membrane repolarization during cardiac muscle cell action potential ; positive regulation of potassium ion transmembrane transport ; potassium ion import across plasma membrane ; potassium ion transmembrane transport ; potassium ion transport ; protein homotetramerization ; regulation of cardiac muscle cell contraction ; regulation of heart rate by cardiac conduction ; regulation of membrane repolarization ; regulation of monoatomic ion transmembrane transport ; regulation of skeletal muscle contraction via regulation of action potential ; relaxation of cardiac muscle ; relaxation of skeletal muscle


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: plasma membrane ; ATP binding ; carbohydrate binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; abscisic acid-activated signaling pathway ; protein phosphorylation ; seed germination


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: chloroplast ; chloroplast stroma ; plastid ; 6-phosphoglucan, water dikinase activity ; ATP binding ; carbohydrate kinase activity ; metal ion binding ; phosphoglucan, water dikinase activity ; phosphogluco-amylopectin water dikinase activity ; starch binding ; protein autophosphorylation ; starch catabolic process ; starch metabolic process


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: chloroplast ; allene-oxide cyclase activity ; auxin-activated signaling pathway ; circadian rhythm ; defense response to fungus ; developmental vegetative growth ; flower development ; induced systemic resistance, jasmonic acid mediated signaling pathway ; jasmonic acid biosynthetic process ; photoperiodism, flowering ; positive regulation of defense response to insect ; response to abscisic acid ; response to absence of light ; response to blue light ; response to ethylene ; response to far red light ; response to hydrogen peroxide ; response to insect ; response to jasmonic acid ; response to light stimulus ; response to metal ion ; response to red light ; response to salicylic acid ; response to salt stress ; response to vitamin B2 ; response to wounding ; unsaturated fatty acid biosynthetic process


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: cytosol ; fibrillar center ; intracellular membrane-bounded organelle ; nucleolus ; nucleoplasm ; rDNA heterochromatin ; 5S rRNA binding ; identical protein binding ; p53 binding ; cellular response to hypoxia ; DNA damage response ; DNA repair ; mitotic G2 DNA damage checkpoint signaling ; negative regulation of phosphatidylinositol 3-kinase signaling ; negative regulation of proteasomal ubiquitin-dependent protein catabolic process ; negative regulation of protein kinase B signaling ; negative regulation of protein-containing complex assembly ; negative regulation of signal transduction by p53 class mediator ; negative regulation of transcription by RNA polymerase II ; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I ; positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; positive regulation of protein K63-linked deubiquitination ; protein localization to nucleolus ; protein localization to nucleoplasm ; protein stabilization ; regulation of aerobic respiration ; regulation of apoptotic process ; regulation of cell cycle ; regulation of protein phosphorylation ; regulation of RIG-I signaling pathway ; regulation of signal transduction by p53 class mediator ; ribosomal large subunit assembly ; rRNA processing


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Input: MMFRTSLMRFAAAFFAIVFVVLVGVARSEECTRTCIAQNCDTLSIRYGKYCGIGHSGCPGEEPCDDLDACCKIHDHCVELNGMTNISCHKKFQRCVNRLSKAIKQSKNKKVGFSTKCPYSVVIPTVNQGMDIGILFSQLGNDMKTEL

Output: endoplasmic reticulum ; extracellular region ; calcium ion binding ; lipid binding ; phospholipase A2 activity ; arachidonic acid secretion ; gravitropism ; lipid catabolic process ; phospholipid metabolic process ; pollen development ; pollen germination ; pollen tube growth ; positive regulation of cell growth ; response to auxin


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cytoplasm ; histone deacetylase complex ; nucleus ; histone deacetylase activity ; zinc ion binding ; chromatin remodeling ; histone deacetylation ; negative regulation of transcription by RNA polymerase II ; regulation of epidermal cell differentiation ; root epidermal cell differentiation


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cytoplasm ; plasmodesma ; ATP binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; protein serine/threonine/tyrosine kinase activity ; protein tyrosine kinase activity ; peptidyl-serine phosphorylation ; peptidyl-threonine phosphorylation ; positive regulation of abscisic acid-activated signaling pathway ; protein autophosphorylation ; protein phosphorylation