Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cell body ; cell projection ; cell surface ; cytoplasm ; extracellular region ; extracellular space ; membrane ; neuron projection ; neuronal cell body ; perinuclear region of cytoplasm ; plasma membrane ; postsynapse ; CCR chemokine receptor binding ; chemoattractant activity ; chemokine activity ; CX3C chemokine receptor binding ; CXCR1 chemokine receptor binding ; integrin binding ; aging ; angiogenesis involved in wound healing ; autocrine signaling ; cell adhesion ; cell chemotaxis ; cell-cell adhesion ; cellular response to interleukin-1 ; cellular response to tumor necrosis factor ; cellular response to type II interferon ; chemokine-mediated signaling pathway ; chemotaxis ; cytokine-mediated signaling pathway ; eosinophil chemotaxis ; extrinsic apoptotic signaling pathway in absence of ligand ; G protein-coupled receptor signaling pathway ; inflammatory response ; inhibitory postsynaptic potential ; integrin activation ; leukocyte migration involved in inflammatory response ; lymphocyte chemotaxis ; microglial cell activation ; microglial cell proliferation ; monocyte chemotaxis ; negative regulation of apoptotic process ; negative regulation of apoptotic signaling pathway ; negative regulation of cell migration ; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ; negative regulation of glutamate receptor signaling pathway ; negative regulation of hippocampal neuron apoptotic process ; negative regulation of interleukin-1 alpha production ; negative regulation of microglial cell activation ; negative regulation of tumor necrosis factor production ; negative regulation of vasoconstriction ; neuron cellular homeostasis ; neutrophil chemotaxis ; platelet activation ; positive chemotaxis ; positive regulation of actin filament bundle assembly ; positive regulation of calcium-independent cell-cell adhesion ; positive regulation of cell adhesion ; positive regulation of cell migration ; positive regulation of cell population proliferation ; positive regulation of ERK1 and ERK2 cascade ; positive regulation of GTPase activity ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of I-kappaB phosphorylation ; positive regulation of inflammatory response ; positive regulation of macrophage chemotaxis ; positive regulation of MAPK cascade ; positive regulation of microglial cell migration ; positive regulation of neuroblast proliferation ; positive regulation of neuron projection development ; positive regulation of NF-kappaB transcription factor activity ; positive regulation of protein kinase B signaling ; positive regulation of release of sequestered calcium ion into cytosol ; positive regulation of smooth muscle cell proliferation ; positive regulation of transcription by RNA polymerase II ; positive regulation of transforming growth factor beta1 production ; regulation of lipopolysaccharide-mediated signaling pathway ; response to hypoxia ; response to ischemia ; wound healing


GO Terms Prediction

Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: nucleolus ; nucleoplasm ; nucleus ; site of DNA damage ; chromatin binding ; damaged DNA binding ; NAD DNA ADP-ribosyltransferase activity ; NAD+ ADP-ribosyltransferase activity ; NAD+- protein-aspartate ADP-ribosyltransferase activity ; NAD+-protein ADP-ribosyltransferase activity ; NAD+-protein-glutamate ADP-ribosyltransferase activity ; NAD+-protein-serine ADP-ribosyltransferase activity ; nucleosome binding ; nucleotidyltransferase activity ; poly-ADP-D-ribose binding ; poly-ADP-D-ribose modification-dependent protein binding ; base-excision repair ; decidualization ; DNA ADP-ribosylation ; DNA repair ; DNA repair-dependent chromatin remodeling ; double-strand break repair ; extrinsic apoptotic signaling pathway ; histone modification ; negative regulation of neuron death ; positive regulation of cell growth involved in cardiac muscle cell development ; protein auto-ADP-ribosylation ; protein poly-ADP-ribosylation


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: extracellular region ; extracellular space ; cysteine-type endopeptidase inhibitor activity ; acute-phase response ; negative regulation of blood coagulation ; negative regulation of endopeptidase activity ; positive regulation of cytosolic calcium ion concentration ; vasodilation


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: extracellular exosome ; extracellular region ; extracellular space ; plasma membrane ; calcium ion binding ; epidermal growth factor receptor binding ; growth factor activity ; guanyl-nucleotide exchange factor activity ; receptor ligand activity ; transmembrane receptor protein tyrosine kinase activator activity ; angiogenesis ; branching morphogenesis of an epithelial tube ; cell population proliferation ; cerebellar granule cell precursor proliferation ; epidermal growth factor receptor signaling pathway ; epidermal growth factor receptor signaling pathway via MAPK cascade ; epithelial cell proliferation ; ERBB2-EGFR signaling pathway ; ERK1 and ERK2 cascade ; mammary gland alveolus development ; negative regulation of cholesterol efflux ; negative regulation of secretion ; peptidyl-tyrosine phosphorylation ; positive regulation of canonical Wnt signaling pathway ; positive regulation of cell migration ; positive regulation of cell population proliferation ; positive regulation of cerebellar granule cell precursor proliferation ; positive regulation of DNA binding ; positive regulation of DNA biosynthetic process ; positive regulation of DNA replication ; positive regulation of DNA-templated transcription ; positive regulation of endothelial cell migration ; positive regulation of endothelial cell proliferation ; positive regulation of epidermal growth factor-activated receptor activity ; positive regulation of epithelial cell proliferation ; positive regulation of epithelial tube formation ; positive regulation of ERK1 and ERK2 cascade ; positive regulation of fibroblast proliferation ; positive regulation of gene expression ; positive regulation of hyaluronan biosynthetic process ; positive regulation of MAP kinase activity ; positive regulation of MAPK cascade ; positive regulation of mitotic nuclear division ; positive regulation of peptidyl-threonine phosphorylation ; positive regulation of peptidyl-tyrosine phosphorylation ; positive regulation of phosphatidylinositol 3-kinase signaling ; positive regulation of phosphorylation ; positive regulation of protein kinase B signaling ; positive regulation of protein localization to early endosome ; positive regulation of protein tyrosine kinase activity ; positive regulation of receptor internalization ; positive regulation of ubiquitin-dependent protein catabolic process ; regulation of calcium ion import ; regulation of peptidyl-tyrosine phosphorylation ; regulation of protein localization to cell surface ; regulation of protein secretion ; regulation of protein transport ; regulation of receptor signaling pathway via JAK-STAT


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; cytoskeleton ; cytosol ; eukaryotic translation elongation factor 1 complex ; fungal-type vacuole membrane ; mitochondrion ; ribosome ; actin filament binding ; GDP binding ; GTP binding ; GTPase activity ; melatonin binding ; protein kinase binding ; ribosome binding ; translation elongation factor activity ; actin filament bundle assembly ; cellular response to amino acid starvation ; negative regulation of protein kinase activity ; negative regulation of protein phosphorylation ; translation ; translational elongation ; tRNA export from nucleus


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; MBF transcription complex ; nucleus ; SBF transcription complex ; DNA binding ; transcription coactivator activity ; G1/S transition of mitotic cell cycle ; positive regulation of reciprocal meiotic recombination ; positive regulation of transcription by RNA polymerase II ; positive regulation of transcription from RNA polymerase II promoter in response to heat stress ; positive regulation of transcription involved in G1/S transition of mitotic cell cycle ; regulation of DNA-templated transcription


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Input: MSANENNLIWIDLEMTGLDPERDRIIEIATLVTDANLNILAEGPTIAVHQSDEQLALMDDWNVRTHTASGLVERVKASTMGDREAELATLEFLKQWVPAGKSPICGNSIGQDRRFLFKYMPELEAYFHYRYLDVSTLKELARRWKPEILDGFTKQGTHQAMDDIRESVAELAYYREHFIKL

Output: cytosol ; 3'-5'-RNA exonuclease activity ; metal ion binding ; nucleic acid binding ; oligoribonucleotidase activity ; single-stranded DNA 3'-5' DNA exonuclease activity ; RNA catabolic process


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Input: MKYQQLENLESGWKWKYLVKKHREGELITRYIEASAAQEAVDVLLSLENEPVLVNGWIDKHMNPELVNRMKQTIRARRKRHFNAEHQHTRKKSIDLEFIVWQRLAGLAQRRGKTLSETIVQLIEDAENKEKYANKMSSLKQDLQALLGKE

Output: cytoplasm ; DNA replication termination region ; phospholipid binding ; sequence-specific DNA binding ; cell division ; chromosome organization ; chromosome segregation ; protein homotetramerization ; regulation of DNA-templated transcription


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Input: MSLINTKIKPFKNQAFKNGEFIEITEKDTEGRWSVFFFYPADFTFVCPTELGDVADHYEELQKLGVDVYAVSTDTHFTHKAWHSSSETIAKIKYAMIGDPTGALTRNFDNMREDEGLADRATFVVDPQGIIQAIEVTAEGIGRDASDLLRKIKAAQYVASHPGEVCPAKWKEGEATLAPSLDLVGKI

Output: alkyl hydroperoxide reductase complex ; cytoplasm ; cytosol ; membrane ; hydroperoxide reductase activity ; identical protein binding ; NADH-dependent peroxiredoxin activity ; oxidoreductase activity, acting on peroxide as acceptor ; peroxidase activity ; thioredoxin peroxidase activity ; cell redox homeostasis ; cellular response to sulfate starvation ; hydrogen peroxide catabolic process ; response to alkyl hydroperoxide ; response to hydroperoxide ; response to oxidative stress ; siderophore biosynthetic process


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: collagen-containing extracellular matrix ; egg coat ; extracellular matrix ; extracellular space ; plasma membrane ; acrosin binding ; carbohydrate binding ; identical protein binding ; receptor ligand activity ; structural constituent of egg coat ; binding of sperm to zona pellucida ; blastocyst formation ; egg coat formation ; humoral immune response mediated by circulating immunoglobulin ; negative regulation of binding of sperm to zona pellucida ; negative regulation of DNA-templated transcription ; oocyte development ; positive regulation of acrosomal vesicle exocytosis ; positive regulation of acrosome reaction ; positive regulation of antral ovarian follicle growth ; positive regulation of DNA-templated transcription ; positive regulation of humoral immune response ; positive regulation of inflammatory response ; positive regulation of interleukin-4 production ; positive regulation of leukocyte migration ; positive regulation of ovarian follicle development ; positive regulation of T cell proliferation ; positive regulation of type II interferon production ; positive regulation of type IV hypersensitivity ; regulation of signaling receptor activity


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: membrane ; NLS-dependent protein nuclear import complex ; nuclear envelope ; nucleus ; choline-phosphate cytidylyltransferase activity ; phosphatidylcholine binding ; CDP-choline pathway ; phosphatidylcholine biosynthetic process


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Input: MYSMQLASCVALTLVLLVNSAPTSSPAKETQQHLEQLLLDLQVLLRGIDNYKNLKLPMMLTFKFYLPKQATELKHLQCLENELGALQRVLDLTQSKSFHLEDAGNFISNIRVTVVKLKGSENKFECQFDDEPATVVEFLRRWIAICQSIISTMTQ

Output: extracellular space ; carbohydrate binding ; cytokine activity ; glycosphingolipid binding ; growth factor activity ; interleukin-2 receptor binding ; kappa-type opioid receptor binding ; activated T cell proliferation ; adaptive immune response ; extrinsic apoptotic signaling pathway in absence of ligand ; G protein-coupled receptor signaling pathway ; gene expression ; interleukin-2-mediated signaling pathway ; leukocyte activation involved in immune response ; lymphocyte proliferation ; negative regulation of B cell apoptotic process ; negative regulation of heart contraction ; negative regulation of inflammatory response ; negative regulation of lymphocyte proliferation ; negative regulation of protein phosphorylation ; negative regulation of T-helper 17 cell differentiation ; positive regulation of activated T cell proliferation ; positive regulation of B cell proliferation ; positive regulation of cytosolic calcium ion concentration ; positive regulation of dendritic spine development ; positive regulation of immunoglobulin production ; positive regulation of interleukin-17 production ; positive regulation of isotype switching to IgG isotypes ; positive regulation of plasma cell differentiation ; positive regulation of protein phosphorylation ; positive regulation of regulatory T cell differentiation ; positive regulation of T cell differentiation ; positive regulation of T cell proliferation ; positive regulation of transcription by RNA polymerase II ; positive regulation of type II interferon production ; positive regulation of tyrosine phosphorylation of STAT protein ; protein kinase C-activating G protein-coupled receptor signaling pathway ; regulation of CD4-positive, alpha-beta T cell proliferation ; regulation of T cell homeostatic proliferation ; response to ethanol ; signal transduction ; T cell proliferation ; transcription by RNA polymerase II ; tyrosine phosphorylation of STAT protein


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Input: MVSQETIKHVKDLIAENEIFVASKTYCPYCHAALNTLFEKLKVPRSKVLVLQLNDMKEGADIQAALYEINGQRTVPNIYINGKHIGGNDDLQELRETGELEELLEPILAN

Output: cytoplasm ; nucleus ; glutathione disulfide oxidoreductase activity ; glutathione peroxidase activity ; glutathione transferase activity ; cellular response to oxidative stress ; protein glutathionylation


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Input: MASEEGQVIACHTVETWNEQLQKANESKTLVVVDFTASWCGPCRFIAPFFADLAKKLPNVLFLKVDTDELKSVASDWAIQAMPTFMFLKEGKILDKVVGAKKDELQSTIAKHLA

Output: cytosol ; enzyme activator activity ; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ; protein-disulfide reductase activity ; positive regulation of catalytic activity


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: cell periphery ; plasma membrane ; carbohydrate:proton symporter activity ; fructose transmembrane transporter activity ; glucose transmembrane transporter activity ; mannose transmembrane transporter activity ; carbohydrate transport ; glucose transmembrane transport ; hexose transmembrane transport ; transmembrane transport


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: centrosome ; cytoplasm ; cytoplasmic microtubule ; cytosol ; kinetochore ; microtubule organizing center ; mitotic spindle ; nucleus ; spindle microtubule ; spindle midzone ; microtubule binding ; astral microtubule organization ; attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation ; cytoplasmic streaming ; establishment of mitotic spindle localization ; meiotic chromosome separation ; meiotic spindle midzone assembly ; meiotic spindle organization ; microtubule polymerization ; mitotic cytokinesis ; mitotic sister chromatid separation ; mitotic spindle assembly ; mitotic spindle midzone assembly ; sister chromatid biorientation


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytoplasm ; mitochondrion ; acetyl-CoA carboxylase activity ; ATP binding ; biotin carboxylase activity ; metal ion binding ; fatty acid biosynthetic process ; long-chain fatty acid biosynthetic process ; malonyl-CoA biosynthetic process


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytoplasm ; kinetochore ; nucleus ; SUMO-targeted ubiquitin ligase complex ; metal ion binding ; ubiquitin-protein transferase activity ; DNA damage response ; DNA repair ; protein sumoylation ; protein ubiquitination ; telomere maintenance


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: cell surface ; endoplasmic reticulum ; extracellular region ; fungal-type cell wall ; hydrolase activity, acting on glycosyl bonds ; fungal-type cell wall organization ; polysaccharide catabolic process


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Input: MNNNVEELLRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIVGNTLLSPSRKDNS

Output: cytosol ; endosome ; ESCRT I complex ; late endosome membrane ; ubiquitin binding ; ATP export ; endosome transport via multivesicular body sorting pathway ; negative regulation of protein-containing complex assembly ; protein targeting to vacuole ; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway


Instruction: Predict the GO term based on the protein sequence.

Output: apoplast ; chloroplast ; chloroplast stroma ; cytoplasm ; cytosol ; endoplasmic reticulum ; intracellular membrane-bounded organelle ; plant-type vacuole ; plasma membrane ; plasmodesma ; camalexin binding ; glutathione binding ; glutathione transferase activity ; peroxidase activity ; protein domain specific binding ; quercitrin binding ; salicylic acid binding ; auxin-activated signaling pathway ; defense response ; glutathione metabolic process ; response to cadmium ion ; response to cold ; response to oomycetes ; response to zinc ion ; toxin catabolic process


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; cytosol ; peroxisome ; metal ion binding ; NAD+ diphosphatase activity ; NADH pyrophosphatase activity ; RNA NAD-cap (NMN-forming) hydrolase activity ; NAD catabolic process ; NADH metabolic process ; NADP catabolic process


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: cell surface ; endoplasmic reticulum membrane ; nuclear envelope ; nucleus ; plasma membrane ; receptor complex ; ATP binding ; phosphatidylinositol 3-kinase binding ; protein tyrosine kinase activity ; transmembrane receptor protein tyrosine kinase activity ; virus receptor activity ; apoptotic cell clearance ; cell migration ; establishment of localization in cell ; forebrain cell migration ; lymphocyte activation ; natural killer cell differentiation ; negative regulation of inflammatory response ; negative regulation of innate immune response ; negative regulation of lymphocyte activation ; negative regulation of neuron apoptotic process ; negative regulation of toll-like receptor signaling pathway ; nervous system development ; neuron apoptotic process ; neuron cellular homeostasis ; neuron migration ; neuropeptide signaling pathway ; ovulation cycle ; phagocytosis ; platelet activation ; platelet aggregation ; positive regulation of kinase activity ; positive regulation of viral life cycle ; protein autophosphorylation ; protein kinase B signaling ; protein phosphorylation ; secretion by cell ; spermatogenesis ; substrate adhesion-dependent cell spreading ; transmembrane receptor protein tyrosine kinase signaling pathway ; vagina development


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cell surface ; dendritic spine ; glutamatergic synapse ; membrane ; neuronal cell body ; plasma membrane ; postsynaptic membrane ; sarcolemma ; smooth endoplasmic reticulum ; T-tubule ; Z disc ; alpha-actinin binding ; calcium-activated potassium channel activity ; calmodulin binding ; inward rectifier potassium channel activity ; protein domain specific binding ; protein homodimerization activity ; small conductance calcium-activated potassium channel activity ; membrane repolarization during atrial cardiac muscle cell action potential ; modulation of chemical synaptic transmission ; positive regulation of potassium ion transport ; potassium ion transmembrane transport ; potassium ion transport ; regulation of neuronal synaptic plasticity ; regulation of potassium ion transmembrane transport


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: brush border membrane ; caveola ; Golgi apparatus ; intracellular membrane-bounded organelle ; lamellipodium ; nucleus ; plasma membrane ; sarcolemma ; N-acylphosphatidylethanolamine-specific phospholipase D activity ; phosphatidylinositol binding ; phospholipase D activity ; protein kinase C binding ; G protein-coupled receptor internalization ; inositol lipid-mediated signaling ; neuron projection development ; phosphatidic acid biosynthetic process ; phospholipid catabolic process ; positive regulation of cell adhesion ; positive regulation of cell migration ; positive regulation of mast cell degranulation ; positive regulation of phosphatidylinositol 3-kinase signaling ; positive regulation of receptor-mediated endocytosis ; receptor-mediated endocytosis ; regulation of vesicle-mediated transport ; response to hydrogen peroxide ; response to hypoxia ; response to organic cyclic compound ; response to peptide hormone


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: actin cytoskeleton ; adherens junction ; brush border ; cell projection ; cell-cell contact zone ; cell-cell junction ; costamere ; cytoplasm ; cytoskeleton ; cytosol ; fascia adherens ; focal adhesion ; inner dense plaque of desmosome ; intercalated disc ; outer dense plaque of desmosome ; plasma membrane ; podosome ; podosome ring ; protein-containing complex ; sarcolemma ; terminal web ; Z disc ; zonula adherens ; actin binding ; alpha-catenin binding ; beta-catenin binding ; dystroglycan binding ; small GTPase binding ; structural molecule activity ; ubiquitin protein ligase binding ; adherens junction assembly ; apical junction assembly ; axon extension ; cell adhesion ; epithelial cell-cell adhesion ; lamellipodium assembly ; morphogenesis of an epithelium ; protein localization to cell surface ; regulation of cell migration ; regulation of establishment of endothelial barrier ; regulation of focal adhesion assembly ; regulation of protein localization to adherens junction


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: basal plasma membrane ; cytoplasm ; dendrite ; excitatory synapse ; extracellular space ; membrane ; neuron projection ; neuronal cell body ; postsynaptic density ; postsynaptic membrane ; receptor complex ; sperm flagellum ; ATP binding ; beta-catenin binding ; hepatocyte growth factor receptor activity ; identical protein binding ; molecular function activator activity ; phosphatidylinositol 3-kinase binding ; phospholipase binding ; protein kinase activity ; protein phosphatase binding ; protein tyrosine kinase activity ; protein-containing complex binding ; semaphorin receptor activity ; adult behavior ; brain development ; branching morphogenesis of an epithelial tube ; cardiac muscle cell development ; cardiac muscle contraction ; cell migration ; cellular response to arsenic-containing substance ; cellular response to glucose stimulus ; cellular response to growth factor stimulus ; cellular response to inorganic substance ; cellular response to interleukin-6 ; cellular response to peptide hormone stimulus ; central nervous system neuron differentiation ; chemical synaptic transmission ; endothelial cell morphogenesis ; establishment of localization in cell ; establishment of skin barrier ; excitatory postsynaptic potential ; flagellated sperm motility ; glucose homeostasis ; glucose transmembrane transport ; hepatocyte growth factor receptor signaling pathway ; lactation ; liver development ; male gonad development ; modulation of chemical synaptic transmission ; muscle cell migration ; muscle organ development ; myoblast proliferation ; myotube differentiation ; negative regulation of gene expression ; negative regulation of guanyl-nucleotide exchange factor activity ; negative regulation of hydrogen peroxide-mediated programmed cell death ; negative regulation of peptidyl-threonine phosphorylation ; negative regulation of Rho protein signal transduction ; negative regulation of stress fiber assembly ; negative regulation of thrombin-activated receptor signaling pathway ; negative regulation of transcription by RNA polymerase II ; negative regulation of transforming growth factor beta production ; nervous system development ; neuron differentiation ; neuron migration ; oligodendrocyte development ; pancreas development ; peptidyl-tyrosine phosphorylation ; phagocytosis ; placenta development ; positive chemotaxis ; positive regulation of dendrite morphogenesis ; positive regulation of DNA replication ; positive regulation of endothelial cell chemotaxis ; positive regulation of gene expression ; positive regulation of glucose transmembrane transport ; positive regulation of kinase activity ; positive regulation of MAPK cascade ; positive regulation of microtubule polymerization ; positive regulation of mitotic nuclear division ; positive regulation of neuron projection development ; positive regulation of p38MAPK cascade ; positive regulation of peptidyl-serine phosphorylation ; positive regulation of peptidyl-threonine phosphorylation ; positive regulation of transcription by RNA polymerase II ; protein autophosphorylation ; reactive oxygen species metabolic process ; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ; regulation of cellular response to oxidative stress ; regulation of interleukin-6 production ; response to acidic pH ; response to organic cyclic compound ; response to peptide hormone ; response to wounding ; response to xenobiotic stimulus ; semaphorin-plexin signaling pathway ; skeletal muscle tissue development ; transmembrane receptor protein tyrosine kinase signaling pathway


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cytoplasm ; cytoplasmic stress granule ; cytosol ; nucleus ; perikaryon ; ribonucleoprotein complex ; ATP binding ; ATP hydrolysis activity ; DNA binding ; DNA helicase activity ; DNA/RNA helicase activity ; endonuclease activity ; mRNA binding ; RNA helicase activity ; defense response to virus ; innate immune response ; negative regulation of canonical Wnt signaling pathway ; positive regulation of stress granule assembly ; positive regulation of type I interferon production ; stress granule assembly


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: axon ; cell junction ; cyclin-dependent protein kinase holoenzyme complex ; cytoplasm ; cytoskeleton ; cytosol ; dendrite ; filopodium ; glutamatergic synapse ; growth cone ; lamellipodium ; membrane ; neuromuscular junction ; neuron projection ; neuronal cell body ; nucleoplasm ; nucleus ; perikaryon ; plasma membrane ; postsynapse ; postsynaptic density ; presynapse ; protein kinase 5 complex ; Schaffer collateral - CA1 synapse ; synapse ; acetylcholine receptor activator activity ; ATP binding ; cyclin-dependent protein serine/threonine kinase activity ; cytoskeletal protein binding ; ephrin receptor binding ; ErbB-2 class receptor binding ; ErbB-3 class receptor binding ; histone kinase activity ; Hsp90 protein binding ; kinase activity ; p53 binding ; protein kinase activity ; protein kinase binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; tau-protein kinase activity ; apoptotic process ; associative learning ; axon extension ; axonogenesis ; behavioral response to cocaine ; calcium ion import ; cell division ; cell migration ; cell-matrix adhesion ; cellular response to amyloid-beta ; central nervous system development ; central nervous system neuron development ; cerebellar cortex development ; cerebellar cortex formation ; cerebellum development ; cerebral cortex development ; corpus callosum development ; cortical actin cytoskeleton organization ; dendrite morphogenesis ; establishment of localization in cell ; excitatory postsynaptic potential ; exocytosis ; forebrain development ; hippocampus development ; intracellular protein transport ; layer formation in cerebral cortex ; mitochondrion organization ; motor neuron axon guidance ; negative regulation of axon extension ; negative regulation of cell cycle ; negative regulation of DNA-templated transcription ; negative regulation of neuron death ; negative regulation of protein export from nucleus ; negative regulation of protein ubiquitination ; negative regulation of proteolysis ; negative regulation of synaptic plasticity ; neuron apoptotic process ; neuron differentiation ; neuron migration ; neuron projection development ; neuron projection morphogenesis ; nucleocytoplasmic transport ; oligodendrocyte differentiation ; peptidyl-serine phosphorylation ; peptidyl-threonine phosphorylation ; phosphorylation ; positive regulation of calcium ion-dependent exocytosis ; positive regulation of glial cell apoptotic process ; positive regulation of neuron apoptotic process ; positive regulation of neuron death ; positive regulation of presynaptic cytosolic calcium concentration ; positive regulation of protein binding ; positive regulation of protein kinase activity ; positive regulation of protein phosphorylation ; positive regulation of protein targeting to membrane ; positive regulation of voltage-gated calcium channel activity ; protein autophosphorylation ; protein localization to synapse ; protein phosphorylation ; receptor catabolic process ; receptor clustering ; regulated exocytosis ; regulation of cell migration ; regulation of dendritic spine morphogenesis ; regulation of postsynaptic membrane potential ; regulation of presynaptic cytosolic calcium ion concentration ; regulation of protein localization to plasma membrane ; regulation of synapse pruning ; regulation of synaptic plasticity ; regulation of synaptic transmission, glutamatergic ; regulation of transcription involved in G1/S transition of mitotic cell cycle ; response to cocaine ; response to wounding ; rhythmic process ; Schwann cell development ; sensory perception of pain ; serine phosphorylation of STAT protein ; skeletal muscle tissue development ; synapse assembly ; synaptic transmission, dopaminergic ; synaptic transmission, glutamatergic ; synaptic vesicle endocytosis ; synaptic vesicle transport ; telencephalon development ; visual learning


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Input: MTQFSALALLLIVFVAASFAQSYDDVSAEKRAMRNALVRFGRASGGMRNALVRFGKRSPLDEEDFAPESPLQGKRNGAPQPFVRFGRSGQLDHMHDLLSTLQKLKFANNK

Output: extracellular region ; neuropeptide receptor binding ; neuropeptide signaling pathway ; sleep


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: centrosome ; cytoplasm ; microtubule ; nuclear envelope ; nuclear membrane ; dynein light intermediate chain binding ; microtubule binding ; protein self-association ; centrosome localization ; chromosome segregation ; cytoplasmic microtubule organization ; cytoskeleton-dependent intracellular transport ; embryo development ending in birth or egg hatching ; nucleus localization ; pronuclear migration


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cell plate ; cytoplasm ; microtubule ; nucleus ; ATP binding ; kinase activity ; MAP kinase activity ; protein kinase activity ; protein serine kinase activity ; protein serine/threonine kinase activity ; cellular response to carbon dioxide ; cortical microtubule organization ; cytokinesis by cell plate formation ; hyperosmotic response ; hypotonic salinity response ; innate immune response ; intracellular signal transduction ; jasmonic acid and ethylene-dependent systemic resistance ; jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway ; male meiosis cytokinesis ; phosphorylation ; pollen development ; protein phosphorylation ; regulation of stomatal closure ; regulation of stomatal movement ; response to abscisic acid ; response to cold ; response to fungus ; response to salt stress ; systemic acquired resistance, salicylic acid mediated signaling pathway


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: lysosomal lumen ; lysosomal membrane ; acyltransferase activity ; heparan-alpha-glucosaminide N-acetyltransferase activity ; heparan sulfate proteoglycan catabolic process ; lysosomal transport ; protein complex oligomerization


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cytoplasm ; cytosol ; ATP binding ; calmodulin-dependent protein kinase activity ; myosin light chain kinase activity ; cardiac myofibril assembly ; cellular response to interleukin-1 ; positive regulation of sarcomere organization ; protein phosphorylation ; regulation of vascular permeability involved in acute inflammatory response ; sarcomere organization ; sarcomerogenesis


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Input: MYLSKVIIARAWSRDLYQLHQGLWHLFPNRPDAARDFLFHVEKRNTPEGCHVLLQSAQMPVSTAVATVIKTKQVEFQLQVGVPLYFRLRANPIKTILDNQKRLDSKGNIKRCRVPLIKEAEQIAWLQRKLGNAARVEDVHPISERPQYFSGDGKSGKIQTVCFEGVLTINDAPALIDLVQQGIGPAKSMGCGLLSLAPL

Output: protein-containing complex ; RNA binding ; RNA endonuclease activity ; CRISPR-cas system ; defense response to virus ; RNA phosphodiester bond hydrolysis, endonucleolytic ; RNA processing


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: cell surface ; external side of plasma membrane ; extracellular space ; interleukin-1 receptor activity ; interleukin-33 binding ; NAD(P)+ nucleosidase activity ; NAD+ nucleotidase, cyclic ADP-ribose generating ; cellular response to mechanical stimulus ; cellular response to peptide ; inflammatory response ; macrophage differentiation ; negative regulation of cell population proliferation ; negative regulation of T-helper 1 type immune response ; negative regulation of type II interferon production ; positive regulation of chemokine production ; positive regulation of inflammatory response ; positive regulation of interleukin-5 production ; positive regulation of macrophage activation ; response to nutrient levels


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: Golgi apparatus ; membrane ; myelin sheath ; plasma membrane ; protein-macromolecule adaptor activity ; defense response to virus ; detection of virus ; innate immune response ; myelination ; phosphatidylserine metabolic process ; phospholipid biosynthetic process ; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity ; positive regulation of serine C-palmitoyltransferase activity ; sphingolipid metabolic process


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: nucleus ; ATP binding ; DNA-binding transcription factor activity ; sequence-specific DNA binding ; defense response ; negative regulation of defense response to bacterium ; response to bacterium ; response to chitin ; response to fungus ; response to salicylic acid


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: bleb ; cytoplasm ; cytoskeleton ; cytosol ; intercalated disc ; nucleoplasm ; nucleus ; stress fiber ; actin filament binding ; identical protein binding ; protein domain specific binding ; protein self-association ; cortical actin cytoskeleton organization ; establishment of centrosome localization ; nuclear migration ; positive regulation of stress fiber assembly ; positive regulation of transcription by RNA polymerase II ; regulation of stress fiber assembly


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: actin cytoskeleton ; cell-cell junction ; cleavage furrow ; cytoplasm ; lamellipodium ; plasma membrane ; stress fiber ; actin binding ; ATP binding ; calmodulin binding ; enzyme binding ; metal ion binding ; myosin light chain kinase activity ; aorta smooth muscle tissue morphogenesis ; bleb assembly ; cellular hypotonic response ; cellular response to calcium ion ; cellular response to potassium ion ; cellular response to xenobiotic stimulus ; positive regulation of calcium ion transport ; positive regulation of cell migration ; positive regulation of wound healing ; protein phosphorylation ; smooth muscle contraction ; tonic smooth muscle contraction


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: plasma membrane ; ATP binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; brassinosteroid mediated signaling pathway ; cell differentiation ; defense response ; positive regulation of innate immune response ; protein phosphorylation ; regulation of defense response to fungus ; regulation of growth ; somatic embryogenesis


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: plasma membrane ; carbohydrate binding ; phosphatase binding ; SH2 domain binding ; sialic acid binding ; adaptive immune response ; cell adhesion ; hematopoietic progenitor cell differentiation ; innate immune response ; negative regulation of calcium-mediated signaling ; negative regulation of immunoglobulin production ; negative regulation of inflammatory response to wounding ; regulation of B cell proliferation ; regulation of immune response


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: extracellular matrix ; extracellular region ; metal ion binding ; metalloendopeptidase activity ; cell migration ; cell-matrix adhesion ; cellular response to BMP stimulus ; cellular response to interleukin-1 ; cellular response to tumor necrosis factor ; chondrocyte differentiation ; collagen fibril organization ; extracellular matrix organization ; negative regulation of cellular response to hepatocyte growth factor stimulus ; negative regulation of cellular response to vascular endothelial growth factor stimulus ; negative regulation of chondrocyte differentiation ; negative regulation of hepatocyte growth factor receptor signaling pathway ; ossification ; ossification involved in bone maturation ; proteoglycan catabolic process ; proteoglycan metabolic process ; proteolysis involved in protein catabolic process ; regulation of endothelial tube morphogenesis ; regulation of inflammatory response


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: plasma membrane ; G protein-coupled receptor activity ; cellular response to pH ; insulin secretion ; monocyte differentiation ; negative regulation of monocyte differentiation ; osteoclast development ; positive regulation of insulin secretion ; positive regulation of insulin secretion involved in cellular response to glucose stimulus ; positive regulation of osteoclast development


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: endoplasmic reticulum membrane ; membrane ; 1-acylglycerophosphocholine O-acyltransferase activity ; 1-acylglycerophosphoethanolamine O-acyltransferase activity ; 1-acylglycerophosphoserine O-acyltransferase activity ; acyltransferase activity ; lipid modification ; phosphatidylethanolamine acyl-chain remodeling ; phosphatidylserine acyl-chain remodeling ; phospholipid biosynthetic process ; regulation of neuron projection development


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: cytoplasm ; nucleus ; sperm cytoplasmic droplet ; penetration of cumulus oophorus ; penetration of zona pellucida ; positive regulation of DNA-templated transcription ; positive regulation of megakaryocyte differentiation ; regulation of proteasomal protein catabolic process ; spermatid development


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Input: MAVTAFNTLKLVSSSLDPIPSVSCSSYSFSLIYVGSPYKRCLKQSCSVRAMTSSSSAASSSSSSFGSRMEESIRKTVTENTVVIYSKTWCSYCTEVKTLFKRLGVQPLVVELDQLGPQGPQLQKVLERLTGQHTVPNVFVCGKHIGGCTDTVKLNRKGDLELMLAEANGKNGQS

Output: chloroplast ; cytoplasm ; glutathione disulfide oxidoreductase activity ; cellular response to oxidative stress ; iron-sulfur cluster assembly


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Input: MDVNLAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISVVGFLSPFNMILGGVIVVLVFMGFVWAAHNKDILRRMKKQYPTAFVMVVMLASYFLISMFGGVMVFVFGITLPLLLMFIHASLRLRNLKNKLENKMEGIGLKKTPMGIILDALEQQEDNINKFADYISKARE

Output: cytoplasm ; cytoskeleton ; endoplasmic reticulum membrane ; membrane ; plasma membrane ; presynaptic cytosol ; transmembrane transporter binding ; cellular response to organic cyclic compound ; glutathione metabolic process ; intrinsic apoptotic signaling pathway in response to oxidative stress ; L-glutamate import across plasma membrane ; L-glutamate transmembrane transport ; learning or memory ; negative regulation of L-glutamate import across plasma membrane ; negative regulation of mitochondrial membrane potential ; negative regulation of transport ; neuron death in response to oxidative stress ; positive regulation of apoptotic process ; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ; positive regulation of stress-activated MAPK cascade ; protein localization to plasma membrane ; protein transport ; regulation of neurotransmitter uptake


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: chloroplast ; chloroplast stroma ; plastid ; omega-amidase activity ; zinc ion binding ; asparagine metabolic process ; glutamine metabolic process ; malate metabolic process ; oxaloacetate metabolic process


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: apical plasma membrane ; plasma membrane ; potassium:proton antiporter activity ; sodium:proton antiporter activity ; determination of adult lifespan ; lipid storage ; nematode larval development ; positive regulation of fatty acid transport ; positive regulation of growth rate ; positive regulation of multicellular organism growth ; potassium ion transmembrane transport ; regulation of intracellular pH ; regulation of peptide transport ; regulation of pH ; regulation of pharyngeal pumping ; reproduction ; sodium ion import across plasma membrane


Instruction: Predict the GO term based on the protein sequence.

Output: chromatin ; cytosol ; dendrite ; neuronal cell body ; nucleolus ; nucleoplasm ; nucleus ; mRNA 3'-UTR binding ; p53 binding ; zinc ion binding ; apoptotic process ; cell cycle ; DNA damage response ; hemostasis ; intracellular mRNA localization ; learning or memory ; locomotory behavior ; megakaryocyte development ; mRNA localization resulting in post-transcriptional regulation of gene expression ; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ; platelet alpha granule organization ; platelet formation ; positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ; positive regulation of fat cell differentiation ; regulation of cytoplasmic translation


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: chromatin ; nuclear speck ; nucleus ; SRF-myogenin-E12 complex ; DNA-binding transcription factor binding ; histone acetyltransferase binding ; histone deacetylase binding ; R-SMAD binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; transcription coactivator activity ; cardiac muscle cell apoptotic process ; cardiac muscle cell differentiation ; cardiac muscle cell myoblast differentiation ; cardiac vascular smooth muscle cell differentiation ; cardiac ventricle development ; cell growth involved in cardiac muscle cell development ; cellular component maintenance ; digestive tract development ; ductus arteriosus closure ; heart development ; hepatic stellate cell activation ; lung alveolus development ; negative regulation of amyloid-beta clearance ; negative regulation of cardiac muscle cell apoptotic process ; negative regulation of cell adhesion molecule production ; negative regulation of cell population proliferation ; negative regulation of cyclin-dependent protein serine/threonine kinase activity ; negative regulation of myotube differentiation ; negative regulation of platelet-derived growth factor receptor-beta signaling pathway ; negative regulation of skeletal muscle cell differentiation ; negative regulation of transcription by RNA polymerase II ; negative regulation of vascular associated smooth muscle cell migration ; negative regulation of vascular associated smooth muscle cell proliferation ; positive regulation of cardiac muscle cell differentiation ; positive regulation of cell population proliferation ; positive regulation of DNA binding ; positive regulation of DNA-binding transcription factor activity ; positive regulation of DNA-templated transcription ; positive regulation of epithelial to mesenchymal transition ; positive regulation of gene expression ; positive regulation of miRNA transcription ; positive regulation of smooth muscle cell differentiation ; positive regulation of smooth muscle contraction ; positive regulation of transcription by RNA polymerase II ; positive regulation of transforming growth factor beta receptor signaling pathway ; regulation of cell growth by extracellular stimulus ; regulation of histone acetylation ; regulation of myoblast differentiation ; regulation of phenotypic switching ; regulation of smooth muscle cell differentiation ; regulation of transcription by RNA polymerase II ; response to hypoxia ; smooth muscle cell differentiation ; transcription by RNA polymerase II ; urinary bladder development ; uterus development ; vascular associated smooth muscle cell differentiation ; vasculogenesis ; ventricular cardiac muscle cell differentiation


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: cytosol ; plasma membrane ; ubiquitin ligase complex ; metal ion binding ; ubiquitin binding ; ubiquitin protein ligase activity ; plant-type hypersensitive response ; positive regulation of plant-type hypersensitive response ; protein ubiquitination ; ubiquitin-dependent protein catabolic process


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: brush border membrane ; endoplasmic reticulum ; endoplasmic reticulum membrane ; microvillus ; plasma membrane ; arachidonate-CoA ligase activity ; long-chain fatty acid transporter activity ; long-chain fatty acid-CoA ligase activity ; nucleotide binding ; oleate transmembrane transporter activity ; oleoyl-CoA ligase activity ; palmitoyl-CoA ligase activity ; very long-chain fatty acid-CoA ligase activity ; activation of GTPase activity ; establishment of localization in cell ; fatty acid metabolic process ; fatty acid transport ; glucose import in response to insulin stimulus ; lipid transport across blood-brain barrier ; long-chain fatty acid import into cell ; long-chain fatty acid metabolic process ; long-chain fatty acid transport ; medium-chain fatty acid transport ; negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity ; negative regulation of insulin receptor signaling pathway ; positive regulation of apoptotic process ; response to nutrient ; skin development ; very long-chain fatty acid catabolic process ; very long-chain fatty acid metabolic process


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: insulin-responsive compartment ; mitochondrion ; perinuclear region of cytoplasm ; plasma membrane ; recycling endosome ; synaptic vesicle membrane ; G protein activity ; GTP binding ; GTPase activity ; glucose import ; protein transport ; Rab protein signal transduction ; regulation of endocytosis ; vesicle-mediated transport


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; endoplasmic reticulum ; endoplasmic reticulum membrane ; membrane ; p53 binding ; ubiquitin protein ligase activity ; zinc ion binding ; endoplasmic reticulum unfolded protein response ; intestinal stem cell homeostasis ; positive regulation of ubiquitin-dependent protein catabolic process ; protein ubiquitination ; regulation of translation in response to endoplasmic reticulum stress ; response to endoplasmic reticulum stress ; ubiquitin-dependent ERAD pathway


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: COPII-coated ER to Golgi transport vesicle ; endoplasmic reticulum ; endoplasmic reticulum membrane ; endoplasmic reticulum-Golgi intermediate compartment ; endoplasmic reticulum-Golgi intermediate compartment membrane ; Golgi apparatus ; Golgi membrane ; synaptic vesicle ; syntaxin binding ; COPI coating of Golgi vesicle ; endoplasmic reticulum to Golgi vesicle-mediated transport ; Golgi organization ; intracellular protein transport ; positive regulation of organelle organization


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: external side of plasma membrane ; plasma membrane ; endopeptidase activator activity ; enzyme binding ; identical protein binding ; BMP signaling pathway ; negative regulation of alpha-beta T cell activation ; negative regulation of CD4-positive, alpha-beta T cell proliferation ; negative regulation of CD8-positive, alpha-beta T cell proliferation ; negative regulation of interleukin-10 production ; negative regulation of interleukin-17 production ; negative regulation of T cell cytokine production ; negative regulation of tumor necrosis factor production ; negative regulation of type II interferon production ; positive regulation of BMP signaling pathway ; positive regulation of cell migration ; positive regulation of collagen catabolic process ; positive regulation of endopeptidase activity ; positive regulation of gene expression ; positive regulation of regulatory T cell differentiation ; positive regulation of stem cell differentiation ; stem cell differentiation ; zymogen activation


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: bicellular tight junction ; cell junction ; cell-cell junction ; cytoplasm ; nucleus ; plasma membrane ; ATP binding ; frizzled binding ; protein phosphatase binding ; positive regulation of JUN kinase activity ; signal transduction


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: mitochondrion ; cell communication ; embryo development ending in seed dormancy ; endosperm cellularization ; endosperm development ; gametophyte development ; mitochondrial membrane organization ; nucleus localization ; pollen development ; pollen germination ; pollen tube development ; regulation of gene expression ; regulation of programmed cell death ; regulation of starch biosynthetic process ; vacuole organization


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cytosol ; mitochondrial matrix ; peroxisome ; plasmodesma ; secretory vesicle ; citrate (Si)-synthase activity ; carbohydrate metabolic process ; fatty acid beta-oxidation ; tricarboxylic acid cycle


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Input: MLGVVELLLLGTAWLAGPARGQNETEPIVLEGKCLVVCDSNPTSDPTGTALGISVRSGSAKVAFSAIRSTNHEPSEMSNRTMIIYFDQVLVNIGNNFDSERSTFIAPRKGIYSFNFHVVKVYNRQTIQVSLMLNGWPVISAFAGDQDVTREAASNGVLIQMEKGDRAYLKLERGNLMGGWKYSTFSGFLVFPL

Output: extracellular region ; glutamatergic synapse ; parallel fiber to Purkinje cell synapse ; postsynaptic membrane ; synapse ; synaptic cleft ; identical protein binding ; cerebellar granule cell differentiation ; establishment of localization in cell ; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ; maintenance of synapse structure ; negative regulation of excitatory postsynaptic potential ; negative regulation of inhibitory synapse assembly ; positive regulation of long-term synaptic depression ; positive regulation of synapse assembly ; protein secretion ; regulation of postsynaptic density assembly ; regulation of presynapse assembly ; synapse assembly ; synapse organization


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Input: MASNFKKTTMASSAQRKRMSPKPELTEDQKQEIREAFDLFDADGTGTIDIKELKVAMRALGFEPKKEEIKKMISEIDKEGTGKMNFSDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVNEQEFLRIMKKTSLY

Output: 9+2 motile cilium ; apical part of cell ; centriole ; centrosome ; ciliary basal body ; cilium ; cytoplasm ; nuclear pore nuclear basket ; photoreceptor connecting cilium ; transcription export complex 2 ; XPC complex ; calcium ion binding ; G-protein beta/gamma-subunit complex binding ; heterotrimeric G-protein binding ; microtubule binding ; cell division ; centriole replication ; mitotic cell cycle ; mRNA transport ; nucleotide-excision repair ; protein transport ; regulation of cytokinesis ; spermatogenesis


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: chloroplast ; plastid ; glycerophosphodiester phosphodiesterase activity ; magnesium ion binding ; cellular response to hypoxia ; glycerol metabolic process ; glycerophospholipid catabolic process ; intracellular phosphate ion homeostasis


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: chloroplast ; chloroplast envelope ; chloroplast inner membrane ; chloroplast thylakoid membrane ; cytosol ; plant-type vacuole ; plasma membrane ; oxidoreductase activity


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: bicellular tight junction ; centriole ; ciliary base ; cytoplasm ; dendrite ; extrinsic component of postsynaptic membrane ; GABA-ergic synapse ; glutamatergic synapse ; late endosome ; nucleus ; perinuclear region of cytoplasm ; photoreceptor inner segment ; photoreceptor outer segment ; plasma membrane ; postsynaptic density ; protein-containing complex ; slit diaphragm ; synapse ; activin receptor binding ; beta-1 adrenergic receptor binding ; kinesin binding ; phosphatase binding ; protein-containing complex binding ; signaling receptor complex adaptor activity ; SMAD binding ; structural constituent of postsynaptic density ; structural constituent of postsynaptic specialization ; type II activin receptor binding ; cellular response to nerve growth factor stimulus ; clathrin-dependent endocytosis ; negative regulation of activin receptor signaling pathway ; negative regulation of cell migration ; negative regulation of cell population proliferation ; negative regulation of protein kinase B signaling ; nerve growth factor signaling pathway ; neuroligin clustering involved in postsynaptic membrane assembly ; podocyte development ; positive regulation of neuron projection development ; positive regulation of phosphoprotein phosphatase activity ; positive regulation of receptor internalization ; positive regulation of synaptic vesicle clustering ; receptor clustering ; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ; regulation of synaptic membrane adhesion ; signal transduction ; SMAD protein signal transduction


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: cell surface ; membrane ; neuronal cell body ; plasma membrane ; voltage-gated potassium channel complex ; potassium channel regulator activity ; serine-type peptidase activity ; establishment of localization in cell ; neuronal action potential ; positive regulation of potassium ion transmembrane transport ; positive regulation of potassium ion transport ; positive regulation of protein localization to plasma membrane ; potassium ion transmembrane transport ; protein localization to plasma membrane ; proteolysis ; regulation of membrane potential ; regulation of potassium ion transmembrane transport ; regulation of potassium ion transport


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: cytoplasm ; nuclear envelope ; nuclear periphery ; nucleoplasm ; nucleus ; GTP binding ; nuclear import signal receptor activity ; nuclear localization sequence binding ; NLS-bearing protein import into nucleus ; protein import into nucleus


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cytosol ; nucleus ; 3'(2'),5'-bisphosphate nucleotidase activity ; inositol-1,3,4-trisphosphate 1-phosphatase activity ; inositol-1,4-bisphosphate 1-phosphatase activity ; metal ion binding ; methionine biosynthetic process ; phosphatidylinositol phosphate biosynthetic process ; sulfate assimilation


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytosol ; mitochondrial inner membrane ; mitochondrial intermembrane space ; mitochondrial matrix ; ATP binding ; ATP-dependent protein folding chaperone ; hydrolase activity ; unfolded protein binding


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: chylomicron ; extracellular exosome ; extracellular matrix ; extracellular space ; high-density lipoprotein particle ; intermediate-density lipoprotein particle ; low-density lipoprotein particle ; multivesicular body, internal vesicle ; very-low-density lipoprotein particle ; heparan sulfate proteoglycan binding ; heparin binding ; identical protein binding ; lipid binding ; low-density lipoprotein particle receptor binding ; cholesterol efflux ; chylomicron remnant clearance ; high-density lipoprotein particle assembly ; intermediate-density lipoprotein particle clearance ; lipoprotein biosynthetic process ; melanosome organization ; negative regulation of amyloid fibril formation ; neuron projection development ; positive regulation of amyloid-beta clearance ; triglyceride-rich lipoprotein particle clearance ; very-low-density lipoprotein particle clearance


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: cytoplasm ; peroxisome ; plasma membrane ; catalase activity ; heme binding ; metal ion binding ; cold acclimation ; hydrogen peroxide catabolic process ; response to abscisic acid ; response to auxin ; response to hydrogen peroxide ; response to oxidative stress ; response to reactive oxygen species ; response to xenobiotic stimulus


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: host cell nucleus ; host cell plasma membrane ; host multivesicular body ; membrane ; viral nucleocapsid ; virion membrane ; aspartic-type endopeptidase activity ; DNA binding ; DNA-directed DNA polymerase activity ; exoribonuclease H activity ; lipid binding ; RNA binding ; RNA-directed DNA polymerase activity ; RNA-DNA hybrid ribonuclease activity ; structural molecule activity ; zinc ion binding ; DNA integration ; DNA recombination ; establishment of integrated proviral latency ; induction by virus of host apoptotic process ; proteolysis ; suppression by virus of host gene expression ; viral entry into host cell ; viral genome integration into host DNA ; viral penetration into host nucleus


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: basolateral plasma membrane ; cell projection ; immunological synapse ; intracellular membrane-bounded organelle ; presynaptic membrane ; synaptic vesicle membrane ; ATP binding ; ATP hydrolysis activity ; calmodulin binding ; metal ion binding ; P-type calcium transporter activity ; PDZ domain binding ; intracellular calcium ion homeostasis ; negative regulation of cytokine production ; negative regulation of cytosolic calcium ion concentration ; positive regulation of bone mineralization ; positive regulation of calcium ion transport ; regulation of blood pressure ; regulation of cellular response to insulin stimulus ; regulation of cytosolic calcium ion concentration ; regulation of vascular associated smooth muscle contraction


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: chloroplast thylakoid membrane ; proton-transporting ATP synthase complex, catalytic core F(1) ; ADP binding ; ATP binding ; proton-transporting ATP synthase activity, rotational mechanism ; proton-transporting ATPase activity, rotational mechanism ; proton motive force-driven ATP synthesis


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: host cell cytoplasm ; host cell nucleus ; host cell plasma membrane ; membrane ; T=4 icosahedral viral capsid ; virion membrane ; RNA binding ; serine-type endopeptidase activity ; structural molecule activity ; fusion of virus membrane with host endosome membrane ; proteolysis ; suppression by virus of host gene expression ; suppression by virus of host toll-like receptor signaling pathway ; viral entry into host cell ; virion attachment to host cell


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytoplasm ; extracellular matrix ; extracellular space ; chemoattractant activity ; cytokine activity ; frizzled binding ; GTPase activator activity ; protein kinase activator activity ; adrenal gland development ; artery morphogenesis ; atrial septum development ; bicellular tight junction assembly ; bone mineralization ; canonical Wnt signaling pathway ; cell fate commitment ; cell migration ; cellular response to mechanical stimulus ; cloacal septation ; convergent extension involved in axis elongation ; embryonic appendage morphogenesis ; embryonic viscerocranium morphogenesis ; epithelial cell apoptotic process ; epithelial to mesenchymal transition ; face morphogenesis ; lung-associated mesenchyme development ; maintenance of epithelial cell apical/basal polarity ; mesenchymal cell proliferation ; mesonephric duct development ; myoblast differentiation ; negative regulation of apoptotic process ; negative regulation of canonical Wnt signaling pathway ; negative regulation of cell death ; negative regulation of cell growth ; negative regulation of cell migration ; negative regulation of cell population proliferation ; negative regulation of DNA-templated transcription ; negative regulation of fibroblast growth factor production ; negative regulation of gene expression ; negative regulation of mesenchymal cell proliferation ; negative regulation of stem cell proliferation ; neuroendocrine cell differentiation ; neuron differentiation ; notochord morphogenesis ; osteoblast differentiation ; outflow tract morphogenesis ; paraxial mesoderm formation ; planar cell polarity pathway involved in axis elongation ; planar cell polarity pathway involved in gastrula mediolateral intercalation ; positive regulation of cell migration ; positive regulation of DNA-templated transcription ; positive regulation of epithelial cell apoptotic process ; positive regulation of gene expression ; positive regulation of GTPase activity ; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway ; positive regulation of protein kinase C signaling ; positive regulation of stress fiber assembly ; positive regulation of transforming growth factor beta2 production ; primary heart field specification ; primary palate development ; protein localization to cell surface ; protein phosphorylation ; secondary heart field specification ; secondary palate development ; skin morphogenesis ; somite development ; stem cell proliferation ; ureteric bud morphogenesis ; ventricular septum morphogenesis ; Wnt signaling pathway, planar cell polarity pathway


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: cytoplasm ; ATP binding ; metal ion binding ; NAD binding ; NAD+ kinase activity ; NAD metabolic process ; NADP biosynthetic process ; phosphorylation


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cytoplasm ; extracellular space ; plasma membrane ; cAMP-dependent protein kinase inhibitor activity ; glucagon receptor binding ; hormone activity ; identical protein binding ; adenylate cyclase-activating G protein-coupled receptor signaling pathway ; adenylate cyclase-modulating G protein-coupled receptor signaling pathway ; cellular response to glucagon stimulus ; gluconeogenesis ; glucose homeostasis ; negative regulation of apoptotic process ; negative regulation of appetite ; negative regulation of cAMP-dependent protein kinase activity ; negative regulation of execution phase of apoptosis ; positive regulation of calcium ion import ; positive regulation of ERK1 and ERK2 cascade ; positive regulation of gluconeogenesis ; positive regulation of histone H3-K4 methylation ; positive regulation of insulin secretion involved in cellular response to glucose stimulus ; positive regulation of peptidyl-serine phosphorylation ; positive regulation of peptidyl-threonine phosphorylation ; positive regulation of protein binding ; positive regulation of protein kinase activity ; protein kinase A signaling ; response to activity


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: peptidoglycan-based cell wall ; plasma membrane ; 8-amino-7-oxononanoate synthase activity ; pyridoxal phosphate binding ; biotin biosynthetic process


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: host cell endoplasmic reticulum-Golgi intermediate compartment membrane ; host cell plasma membrane ; membrane ; viral envelope ; virion membrane ; endocytosis involved in viral entry into host cell ; fusion of virus membrane with host endosome membrane ; fusion of virus membrane with host plasma membrane ; receptor-mediated virion attachment to host cell


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: early endosome ; Golgi apparatus ; plasma membrane ; receptor complex ; beta2-adrenergic receptor activity ; norepinephrine binding ; protein homodimerization activity ; activation of adenylate cyclase activity ; adenylate cyclase-activating adrenergic receptor signaling pathway ; desensitization of G protein-coupled receptor signaling pathway by arrestin ; negative regulation of smooth muscle contraction ; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure ; positive regulation of autophagosome maturation ; positive regulation of lipophagy ; positive regulation of MAPK cascade ; receptor-mediated endocytosis


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: cytoplasm ; cytoplasmic stress granule ; cytosol ; nucleus ; P-body ; C5-methylcytidine-containing RNA binding ; N6-methyladenosine-containing RNA binding ; cell cycle ; embryonic morphogenesis ; endothelial to hematopoietic transition ; gamete generation ; hematopoietic stem cell proliferation ; innate immune response ; mRNA catabolic process ; mRNA destabilization ; negative regulation of Notch signaling pathway ; negative regulation of stem cell differentiation ; negative regulation of type I interferon-mediated signaling pathway ; oocyte maturation ; organelle assembly ; positive regulation of cap-independent translational initiation ; regulation of cell adhesion ; regulation of hematopoietic stem cell differentiation ; regulation of meiotic cell cycle process involved in oocyte maturation ; regulation of mRNA stability ; regulation of neurogenesis ; regulation of rRNA processing ; spermatogonial cell division ; stress granule assembly


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: cytoplasm ; nuclear speck ; nucleolus ; nucleus ; spliceosomal complex ; ATP binding ; ATP hydrolysis activity ; mRNA 3'-UTR binding ; nuclear androgen receptor binding ; promoter-specific chromatin binding ; ribonucleoprotein complex binding ; RNA helicase activity ; alternative mRNA splicing, via spliceosome ; androgen receptor signaling pathway ; epithelial to mesenchymal transition ; intracellular estrogen receptor signaling pathway ; intrinsic apoptotic signaling pathway by p53 class mediator ; miRNA transcription ; myoblast differentiation ; negative regulation of transcription by RNA polymerase II ; nuclear-transcribed mRNA catabolic process ; positive regulation of DNA damage response, signal transduction by p53 class mediator ; regulation of alternative mRNA splicing, via spliceosome ; regulation of androgen receptor signaling pathway ; regulation of osteoblast differentiation ; regulation of skeletal muscle cell differentiation ; regulation of transcription by RNA polymerase II ; rhythmic process


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: Golgi membrane ; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ; ganglioside biosynthetic process ; glycosphingolipid biosynthetic process ; protein glycosylation


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Input: MRYLVISLFAVSLLMAGSALVGNAADAAKAPKKAIELKHGTSKRMHVMFNHTTHKDIACEQCHHDSPAPDKPYASCTDNDCHATPGPRERDTMSMFVAYHAKDTDRSCYGCHKKMAAQHPEFTGCRPCHMSQQARKEAAASEKK

Output: formate dehydrogenase complex ; periplasmic space ; electron transfer activity ; heme binding ; metal ion binding ; anaerobic respiration


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: extracellular region ; metal ion binding ; serine-type endopeptidase activity ; proteolysis


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: membrane ; plasma membrane ; symbiont-containing vacuole


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: chromosome ; cytoplasm ; extracellular region ; nucleus ; bubble DNA binding ; DNA binding, bending ; four-way junction DNA binding ; non-sequence-specific DNA binding, bending ; supercoiled DNA binding ; DNA geometric change ; inflammatory response ; innate immune response ; regulation of transcription by RNA polymerase II


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: plasma membrane ; 1,2-diacylglycerol 3-beta-galactosyltransferase activity ; hexosyltransferase activity ; enterobacterial common antigen biosynthetic process ; glycerol metabolic process ; membrane lipid biosynthetic process


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: plasma membrane ; ATP binding ; metal ion binding ; transmembrane receptor protein tyrosine kinase activity ; protein phosphorylation


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytosol ; mitochondrial matrix ; mitochondrion ; nucleus ; branched-chain-amino-acid transaminase activity ; L-isoleucine transaminase activity ; L-leucine transaminase activity ; L-leucine:2-oxoglutarate aminotransferase activity ; L-valine transaminase activity ; pyridoxal phosphate binding ; isoleucine biosynthetic process ; leucine biosynthetic process ; valine biosynthetic process


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: actin fusion focus ; cell cortex of cell tip ; cortical dynamic polarity patch ; division septum ; plasma membrane ; CTP binding ; G protein activity ; GDP binding ; GTP binding ; UTP binding ; conjugation with cellular fusion ; establishment or maintenance of cell polarity regulating cell shape ; positive regulation of mating projection assembly ; positive regulation of pheromone response MAPK cascade ; positive regulation of protein import into nucleus ; protein localization to plasma membrane ; signal transduction involved in positive regulation of conjugation with cellular fusion


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: extracellular region ; metal ion binding ; metalloendopeptidase activity ; toxin activity ; proteolysis


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Input: MVKAVCVLAGSGDVKGVVHFEQQDEGAVSVEGKIEGLTDGLHGFHIHVFGDNTNGCMSAGSHFNPENKNHGAPGDTDRHVGDLGNVTAEGGVAQFKITDSLISLKGPNSIIGRTAVVHEKADDLGKGGNDESLKTGNAGGRLACGVIGYSP

Output: cytoplasm ; nucleus ; copper ion binding ; superoxide dismutase activity


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Input: MRTLWIMAVLLVGVEGSLIEFAKMILEETKRLPFPYYTTYGCYCGWGGQGQPKDATDRCCFVHDCCYGKLSNCKPKTDRYSYSRKSGVIICGEGTPCEKQICECDKAAAVCFRENLRTYKKRYMAYPDLLCKKPAEKC

Output: extracellular region ; calcium ion binding ; phospholipase A2 activity ; toxin activity ; arachidonic acid secretion ; defense response to bacterium ; lipid catabolic process ; phospholipid metabolic process


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Input: EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT

Output: extracellular region ; ion channel regulator activity ; toxin activity


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: ATP binding ; DNA binding ; hydrolase activity ; magnesium ion binding ; protein serine/threonine kinase activity ; phosphorylation ; regulation of circadian rhythm ; regulation of DNA-templated transcription


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: plasma membrane ; respirasome ; cytochrome-c oxidase activity ; heme binding ; metal ion binding ; oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor ; ATP synthesis coupled electron transport


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: membrane ; scavenger receptor activity ; serine-type endopeptidase activity ; proteolysis


Instruction: Predict the GO term based on the protein sequence.

Output: chromatin ; nucleolus ; nucleoplasm ; nucleus ; ATP binding ; ATP hydrolysis activity ; ATP-dependent chromatin remodeler activity ; chromatin binding ; DNA binding ; helicase activity ; histone binding ; promoter-specific chromatin binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; adult heart development ; adult walking behavior ; aorta morphogenesis ; atrioventricular canal development ; blood circulation ; blood vessel remodeling ; cardiac septum morphogenesis ; central nervous system development ; chordate embryonic development ; chromatin remodeling ; cognition ; cranial nerve development ; embryonic hindlimb morphogenesis ; epithelium development ; face development ; female genitalia development ; heart morphogenesis ; inner ear morphogenesis ; innervation ; nose development ; olfactory behavior ; olfactory bulb development ; olfactory nerve development ; positive regulation of multicellular organism growth ; positive regulation of transcription by RNA polymerase II ; regulation of gene expression ; regulation of growth hormone secretion ; regulation of neurogenesis ; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ; response to bacterium ; retina development in camera-type eye ; right ventricular compact myocardium morphogenesis ; rRNA processing ; secondary palate development ; semicircular canal morphogenesis ; sensory perception of sound ; skeletal system development ; T cell differentiation ; transcription by RNA polymerase II ; ventricular trabecula myocardium morphogenesis


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cell division site ; cytoplasm ; microtubule ; ATP hydrolysis activity ; GTP binding ; GTPase activity ; cell septum assembly ; FtsZ-dependent cytokinesis ; microtubule-based process ; protein polymerization


Instruction: Predict the GO term based on the protein sequence.

Output: endoplasmic reticulum membrane ; aromatase activity ; estrogen 16-alpha-hydroxylase activity ; estrogen 2-hydroxylase activity ; heme binding ; hydroperoxy icosatetraenoate dehydratase activity ; iron ion binding ; arachidonic acid metabolic process ; cholesterol metabolic process ; estrogen metabolic process ; retinol metabolic process


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Input: MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRYRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQYSKSRRS

Output: axon ; cytosol ; late endosome membrane ; lysosomal membrane ; lysosome ; spindle ; synapse ; G protein activity ; GTP binding ; antigen processing and presentation following phagocytosis ; antigen processing and presentation of polysaccharide antigen via MHC class II ; autophagosome-lysosome fusion ; calcium ion regulated lysosome exocytosis ; cell division ; chromosome segregation ; endosome to lysosome transport of low-density lipoprotein particle ; late endosome to lysosome transport ; lysosome localization ; natural killer cell mediated cytotoxicity ; phagosome-lysosome fusion ; plasma membrane repair ; protein transport


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: Gram-negative-bacterium-type cell wall ; plasma membrane ; side of membrane ; alkaline phosphatase activity ; glucose-6-phosphatase activity ; metal ion binding ; phosphoglycerate phosphatase activity ; sugar-phosphatase activity ; zinc ion binding ; dephosphorylation ; fructose 6-phosphate metabolic process ; phosphocreatine metabolic process


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: autophagosome membrane ; axon ; clathrin-coated vesicle membrane ; dendritic spine membrane ; endoplasmic reticulum membrane ; endosome membrane ; external side of plasma membrane ; lysosomal membrane ; postsynaptic membrane ; synaptic vesicle membrane ; vacuolar proton-transporting V-type ATPase complex ; vacuolar proton-transporting V-type ATPase, V0 domain ; signaling receptor activity ; angiotensin maturation ; central nervous system maturation ; eye pigmentation ; head morphogenesis ; lysosomal lumen acidification ; positive regulation of canonical Wnt signaling pathway ; positive regulation of transforming growth factor beta1 production ; regulation of MAPK cascade ; rostrocaudal neural tube patterning


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: plasma membrane ; IgG binding


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Input: MPKTRRQRTRRARRNRPPTPWPISQDLDRASYMDTPSTCLAIVYRPIGVPSQVVYVPPAYIDMPSWPPVQSTNSPGTPSMDALSALLSNTLSLASPPSPPREPQGPSRSLPLPPLLSPPRFHLPSFNQCESTPPTEMDAWNQPSGISSPPSPSPNLASVPKTSTPPGEKP

Output: host cell cytoplasm ; host cell nucleolus ; RNA binding ; mRNA transport


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: mitochondrion ; nucleus ; 4 iron, 4 sulfur cluster binding ; 5'-3' DNA helicase activity ; 5'-flap endonuclease activity ; ATP binding ; ATP hydrolysis activity ; DNA binding ; DNA helicase activity ; metal ion binding ; nuclease activity ; single-stranded DNA helicase activity ; site-specific endodeoxyribonuclease activity, specific for altered base ; base-excision repair ; DNA double-strand break processing ; DNA replication ; DNA replication checkpoint signaling ; DNA replication, Okazaki fragment processing ; DNA replication, removal of RNA primer ; double-strand break repair via single-strand annealing ; mitochondrial DNA replication ; positive regulation of DNA replication


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: extracellular region ; metal ion binding ; metalloendopeptidase activity ; toxin activity ; proteolysis


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: 2,6-dihydroxypyridine 3-monooxygenase activity ; FAD binding ; flavin adenine dinucleotide binding ; protein homodimerization activity ; nicotine catabolic process


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: extracellular region ; Golgi apparatus ; Golgi cisterna membrane ; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ; glycosphingolipid biosynthetic process ; N-glycan fucosylation ; protein N-linked glycosylation ; protein O-linked glycosylation


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytoplasm ; cytosol ; nucleus ; mRNA (cytidine-5-)-methyltransferase activity ; tRNA (cytosine-5-)-methyltransferase activity ; tRNA binding ; tRNA C5-cytosine methylation ; tRNA methylation


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: host cell nucleus ; host cell plasma membrane ; host multivesicular body ; membrane ; viral nucleocapsid ; virion membrane ; RNA binding ; structural molecule activity ; zinc ion binding ; viral budding via host ESCRT complex


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasmic vesicle ; membrane ; rhoptry ; aspartic-type endopeptidase activity ; entry into host cell by a symbiont-containing vacuole ; protein processing


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: acyltransferase activity ; ligase activity ; methyltransferase activity ; oxidoreductase activity ; phosphopantetheine binding ; heterocycle biosynthetic process ; methylation ; organic cyclic compound biosynthetic process ; organonitrogen compound biosynthetic process ; secondary metabolite biosynthetic process


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: fatty acid beta-oxidation multienzyme complex ; 3-hydroxyacyl-CoA dehydrogenase activity ; 3-hydroxybutyryl-CoA epimerase activity ; delta(3)-delta(2)-enoyl-CoA isomerase activity ; enoyl-CoA hydratase activity ; NAD+ binding ; fatty acid beta-oxidation


Instruction: Predict the GO term based on the protein sequence.

Output: carboxysome ; cytoplasm ; glucosamine-1-phosphate N-acetyltransferase activity ; magnesium ion binding ; structural constituent of carboxysome shell ; UDP-N-acetylglucosamine diphosphorylase activity ; cell morphogenesis ; cell wall organization ; lipid A biosynthetic process ; peptidoglycan biosynthetic process ; regulation of cell shape ; UDP-N-acetylglucosamine biosynthetic process


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Input: MVNLWEDMETGPNAPDEIYAVVECLKGERNKYEYDKDIPGVVLDRVLHSNVHYPSDYGFIPQTYYDDEDPFDVLVLVEDQTFPGCVIEARPVALMKMDDDGEQDDKVIAVPVEDPRYDHIEDLDDIPQQTLDEIDEFFATYKNLEAGKEVETLGWEDKQAAKDAIEHAMDLYEENFA

Output: cytoplasm ; inorganic diphosphate phosphatase activity ; magnesium ion binding ; phosphate-containing compound metabolic process


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: extracellular region ; cellulase activity ; cellulose binding ; cellulose catabolic process


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Input: MDAPRRSSRLAAKIANVLDSKGTIIPEAAPVMLKKPAKDESVDSTIQVGDVIPDITLPDEDGTSIRLRDITANKGLVIFAYPKASTPGCTKQGCGFRDNYPKIQASDYEVLGLSFDTSKAQKAFKDKQNFPYHLLSDPKGELIKKLGAEKPGGGKLFRSHWIFEKGTGKCIVKEIDISPLVSVDKAFAVITDSEP

Output: cytoplasm ; cytosol ; nucleus ; thioredoxin peroxidase activity ; thioredoxin-dependent peroxiredoxin activity ; cell redox homeostasis ; cellular detoxification of hydrogen peroxide ; cellular response to oxidative stress ; hydrogen peroxide catabolic process ; removal of superoxide radicals


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: host cell nuclear matrix ; host cell nucleus ; DNA binding ; double-stranded DNA binding ; single-stranded DNA binding ; DNA replication ; viral DNA genome replication ; viral DNA strand displacement replication


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: extracellular region ; metal ion binding


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: extracellular region ; endo-1,4-beta-xylanase activity ; xylan catabolic process


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Input: MASGVMVSDDVIKVFNEMKVRHQLSPEDAKKRKKAVVFCLSDDKKTIILEPGKEILQGDIGCNVEDPYKTFVKMLPRNDCRYALYDALYETKETKKEDLVFVFWAPEEASLKSKMIYASSKDAIKKRLPGIKHEWQINTYEDVNDPCNLADKLGGNTVVSLEGKSVRS

Output: actin cytoskeleton ; cell cortex ; cytoplasm ; membrane ; midbody ; nuclear matrix ; actin filament binding ; actin filament depolymerization ; cytoskeleton organization ; cytoskeleton-dependent cytokinesis ; regulation of cell morphogenesis


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytoplasm ; plasma membrane ; aspartic-type endopeptidase activity ; polyubiquitin modification-dependent protein binding ; SNARE binding ; proteasome-mediated ubiquitin-dependent protein catabolic process ; protein transport ; regulation of exocytosis


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: -3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity ; -3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity ; -3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity ; beta-N-acetylglucosaminidase activity ; carbohydrate metabolic process ; protein deglycosylation


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: nucleus ; beta-catenin binding ; sequence-specific DNA binding ; cell migration involved in gastrulation ; endoderm development ; foregut morphogenesis ; hindgut morphogenesis ; midgut development ; negative regulation of canonical Wnt signaling pathway ; negative regulation of cell population proliferation ; positive regulation of DNA-templated transcription ; positive regulation of transcription by RNA polymerase II ; Wnt signaling pathway


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: fatty acid synthase complex ; (3R)-hydroxymyristoyl- dehydratase activity ; (3R)-hydroxypalmitoyl- dehydratase activity ;  S-acetyltransferase activity ;  S-malonyltransferase activity ; enoyl- reductase (NADH) activity ; enoyl- reductase activity ; fatty-acyl-CoA synthase activity ; myristoyl- hydrolase activity ; oleoyl- hydrolase activity ; palmitoyl- hydrolase activity ; long-chain fatty acid biosynthetic process


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: 1,4-alpha-glucan branching enzyme activity ; 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) ; nucleotide binding ; alpha-glucan biosynthetic process


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: cytoplasm ; cytosol ; endomembrane system ; nuclear speck ; nucleus ; plasma membrane ; metal ion binding ; phosphatidylinositol phosphate binding ; ubiquitin protein ligase activity ; apoptotic process ; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ; negative regulation of signal transduction by p53 class mediator ; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway ; proteasome-mediated ubiquitin-dependent protein catabolic process ; protein K48-linked ubiquitination ; protein ubiquitination ; regulation of oxygen metabolic process ; ubiquitin-dependent protein catabolic process


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytosol ; early endosome ; Golgi membrane ; nucleoplasm ; perinuclear region of cytoplasm ; phagocytic vesicle ; recycling endosome ; recycling endosome membrane ; SNARE complex ; trans-Golgi network membrane ; SNAP receptor activity ; syntaxin binding ; endocytic recycling ; endosome organization ; Golgi vesicle transport ; intracellular protein transport ; regulation of protein localization ; retrograde transport, endosome to Golgi ; vesicle fusion


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytosol ; endoplasmic reticulum ; extracellular region ; extracellular space ; extrinsic component of mitochondrial inner membrane ; mitochondrial inner membrane ; nuclear membrane ; plasma membrane ; antioxidant activity ; chondroitin sulfate binding ; collagen fibril binding ; heme binding ; IgA binding ; oxidoreductase activity ; oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ; protein homodimerization activity ; serine-type endopeptidase inhibitor activity ; cellular oxidant detoxification ; cellular response to reactive oxygen species ; cytochrome c metabolic process ; hemoglobin metabolic process ; negative regulation of peptidase activity


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: membrane ; ATP binding ; calcium ion binding ; calmodulin binding ; calmodulin-dependent protein kinase activity ; protein serine kinase activity ; nodulation ; protein phosphorylation