GO Terms Prediction

Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: endoplasmic reticulum ; endoplasmic reticulum membrane ; endoplasmic reticulum quality control compartment ; metal ion binding ; ubiquitin protein ligase activity ; ubiquitin-protein transferase activity ; central nervous system development ; endoplasmic reticulum mannose trimming ; protein ubiquitination ; ubiquitin-dependent ERAD pathway


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cytosol ; plasma membrane ; insulin receptor binding ; phosphatidylinositol 3-kinase binding ; insulin receptor signaling pathway ; signal transduction


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: cytoplasm ; cytosol ; extracellular exosome ; ATP binding ; metal ion binding ; phosphoribosylformylglycinamidine synthase activity ; 'de novo' AMP biosynthetic process ; 'de novo' IMP biosynthetic process ; 'de novo' XMP biosynthetic process ; anterior head development ; glutamine metabolic process ; GMP biosynthetic process ; purine nucleotide biosynthetic process ; purine ribonucleoside monophosphate biosynthetic process ; response to xenobiotic stimulus


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: endoplasmic reticulum ; endoplasmic reticulum membrane ; endoplasmic reticulum-Golgi intermediate compartment membrane ; Golgi membrane ; lumenal side of endoplasmic reticulum membrane ; membrane ; MHC class I peptide loading complex ; phagocytic vesicle membrane ; Tapasin-ERp57 complex ; ABC-type peptide antigen transporter activity ; MHC class I protein binding ; molecular adaptor activity ; peptide antigen binding ; TAP complex binding ; TAP1 binding ; TAP2 binding ; unfolded protein binding ; antigen processing and presentation of endogenous peptide antigen via MHC class I ; immune response ; MHC class I protein complex assembly ; MHC class Ib protein complex assembly ; peptide antigen assembly with MHC class I protein complex ; peptide antigen stabilization ; protein-containing complex assembly ; regulation of gene expression ; regulation of protein complex stability ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Input: MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA

Output: cytosol ; nucleus ; fatty acid binding ; lipid binding ; epithelial cell proliferation ; fatty acid transport ; negative regulation of cell population proliferation ; nervous system development


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: chromosome ; cytoplasm ; cytosol ; nucleoplasm ; nucleus ; replication fork ; transcription preinitiation complex ; 3'-5' DNA helicase activity ; ATP binding ; ATP hydrolysis activity ; DNA helicase activity ; enzyme activator activity ; four-way junction helicase activity ; helicase activity ; identical protein binding ; molecular function inhibitor activity ; nucleic acid binding ; RNA polymerase II complex binding ; cell division ; cellular response to camptothecin ; cellular response to ketone ; cellular response to xenobiotic stimulus ; chromosome separation ; DNA metabolic process ; DNA repair ; DNA replication ; DNA unwinding involved in DNA replication ; double-strand break repair via homologous recombination ; mitotic cell cycle ; mitotic DNA-templated DNA replication ; negative regulation of double-strand break repair via homologous recombination ; negative regulation of transcription elongation by RNA polymerase II ; replication-born double-strand break repair via sister chromatid exchange


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cell surface ; endoplasmic reticulum membrane ; extracellular region ; glutamatergic synapse ; Golgi membrane ; neuron projection ; nucleus ; postsynaptic density ; postsynaptic endosome ; postsynaptic membrane ; amyloid-beta binding ; calcium ion binding ; kinesin binding ; X11-like protein binding ; cell adhesion ; homophilic cell adhesion via plasma membrane adhesion molecules ; neurotransmitter receptor transport to postsynaptic membrane ; positive regulation of synapse assembly ; positive regulation of synaptic transmission ; regulation of cell growth ; regulation of synapse maturation ; vesicle-mediated transport in synapse


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: endoplasmic reticulum membrane ; intracellular membrane-bounded organelle ; aromatase activity ; caffeine oxidase activity ; demethylase activity ; electron transfer activity ; enzyme binding ; estrogen 16-alpha-hydroxylase activity ; estrogen 2-hydroxylase activity ; heme binding ; hydroperoxy icosatetraenoate dehydratase activity ; iron ion binding ; monooxygenase activity ; oxidoreductase activity ; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ; aflatoxin metabolic process ; alkaloid metabolic process ; cellular respiration ; cellular response to cadmium ion ; cholesterol metabolic process ; dibenzo-p-dioxin metabolic process ; epoxygenase P450 pathway ; estrogen metabolic process ; heterocycle metabolic process ; hydrogen peroxide biosynthetic process ; long-chain fatty acid biosynthetic process ; lung development ; methylation ; monocarboxylic acid metabolic process ; monoterpenoid metabolic process ; omega-hydroxylase P450 pathway ; oxidative demethylation ; porphyrin-containing compound metabolic process ; post-embryonic development ; regulation of gene expression ; retinol metabolic process ; steroid catabolic process ; toxin biosynthetic process ; xenobiotic catabolic process ; xenobiotic metabolic process


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: cytoplasm ; endoplasmic reticulum ; extracellular exosome ; extracellular matrix ; extracellular region ; extracellular space ; perinuclear region of cytoplasm ; specific granule lumen ; carbohydrate binding ; chitin binding ; extracellular matrix structural constituent ; activation of NF-kappaB-inducing kinase activity ; apoptotic process ; carbohydrate metabolic process ; cartilage development ; cellular response to tumor necrosis factor ; chitin catabolic process ; inflammatory response ; lung development ; positive regulation of angiogenesis ; positive regulation of ERK1 and ERK2 cascade ; positive regulation of interleukin-8 production ; positive regulation of peptidyl-threonine phosphorylation ; positive regulation of protein kinase B signaling ; response to interleukin-1 ; response to interleukin-6 ; response to mechanical stimulus ; response to tumor necrosis factor


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytosol ; perinuclear region of cytoplasm ; protein-containing complex ; calmodulin-dependent protein phosphatase activity ; metal ion binding ; myosin phosphatase activity ; protein serine/threonine phosphatase activity ; protein tyrosine/serine/threonine phosphatase activity ; cellular response to xenobiotic stimulus ; intrinsic apoptotic signaling pathway ; negative regulation of cell-cell adhesion mediated by cadherin ; negative regulation of DNA-templated transcription ; negative regulation of peptidyl-serine phosphorylation ; negative regulation of protein kinase activity ; negative regulation of protein kinase activity by regulation of protein phosphorylation ; negative regulation of protein transport ; peptidyl-serine dephosphorylation ; peptidyl-threonine dephosphorylation ; positive regulation of cell migration ; positive regulation of cell-substrate adhesion ; positive regulation of chemotaxis ; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ; positive regulation of epithelial cell migration ; positive regulation of focal adhesion assembly ; positive regulation of gene expression ; positive regulation of growth ; positive regulation of stress fiber assembly ; protein dephosphorylation ; regulation of protein localization


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: acrosomal vesicle ; intermediate filament cytoskeleton ; membrane ; nuclear speck ; nucleoplasm ; nucleus ; ATP binding ; identical protein binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; protein serine/threonine/tyrosine kinase activity ; protein tyrosine kinase activity ; RNA binding ; peptidyl-tyrosine phosphorylation ; protein autophosphorylation ; protein phosphorylation ; regulation of RNA splicing


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: extracellular exosome ; L-type voltage-gated calcium channel complex ; neuronal dense core vesicle ; plasma membrane ; sarcoplasmic reticulum ; voltage-gated calcium channel complex ; metal ion binding ; voltage-gated calcium channel activity ; calcium ion import across plasma membrane ; calcium ion transmembrane transport ; calcium ion transmembrane transport via high voltage-gated calcium channel ; calcium ion transport ; calcium ion transport into cytosol ; cardiac muscle cell action potential involved in contraction ; cellular response to amyloid-beta ; membrane depolarization during bundle of His cell action potential ; positive regulation of high voltage-gated calcium channel activity ; positive regulation of muscle contraction ; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ; regulation of calcium ion transport ; regulation of heart rate by cardiac conduction ; regulation of membrane repolarization during action potential ; regulation of ventricular cardiac muscle cell membrane repolarization


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: cytosol ; extracellular region ; extracellular space ; rough endoplasmic reticulum ; serine-type endopeptidase activity ; serine-type peptidase activity ; blood coagulation ; proteolysis ; zymogen activation


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cell projection ; cytoplasmic stress granule ; cytosol ; focal adhesion ; plasma membrane ; identical protein binding ; phosphatidylinositol binding ; protein kinase binding ; RNA binding ; epidermal growth factor receptor signaling pathway ; negative regulation of translation ; positive regulation of cell migration ; stress granule assembly


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: apical plasma membrane ; cell projection ; chloride channel complex ; extracellular exosome ; membrane raft ; nucleoplasm ; plasma membrane ; presynapse ; calcium activated cation channel activity ; chloride channel activity ; identical protein binding ; intracellular calcium activated chloride channel activity ; iodide transmembrane transporter activity ; metal ion binding ; protein homodimerization activity ; signaling receptor binding ; voltage-gated chloride channel activity ; cellular response to heat ; cellular response to peptide ; chloride transmembrane transport ; chloride transport ; detection of temperature stimulus involved in sensory perception of pain ; glial cell projection elongation ; iodide transport ; monoatomic cation transport ; monoatomic ion transmembrane transport ; mucus secretion ; phospholipase C-activating G protein-coupled receptor signaling pathway ; positive regulation of insulin secretion involved in cellular response to glucose stimulus ; protein localization to membrane


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytoplasm ; membrane ; nucleoplasm ; nucleus ; apoptotic process ; cell migration ; cell population proliferation ; DNA damage response ; glucose metabolic process ; mitochondrion localization ; positive regulation of cell growth ; positive regulation of protein phosphorylation ; response to ionizing radiation


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: mitochondrion ; aminopeptidase activity ; metal ion binding ; metalloaminopeptidase activity ; metalloexopeptidase activity ; N-terminal protein amino acid modification ; peptidyl-methionine modification ; protein initiator methionine removal ; proteolysis


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: axon ; extracellular region ; plasma membrane ; cell-cell adhesion mediator activity ; axon guidance ; axonal fasciculation ; axonogenesis ; brain development ; dendrite self-avoidance ; homophilic cell adhesion via plasma membrane adhesion molecules ; negative regulation of neuron differentiation ; nervous system development ; neuron cell-cell adhesion ; neuron projection development ; regulation of synaptic plasticity


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: bicellular tight junction ; cytoplasmic vesicle ; cytosol ; plasma membrane ; identical protein binding ; actin cytoskeleton organization ; angiogenesis ; establishment of cell polarity involved in ameboidal cell migration ; hippo signaling ; regulation of cell migration ; Wnt signaling pathway


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: membrane ; phospholipid binding


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: actin cytoskeleton ; cytoplasm ; cytosol ; fibrillar center ; nucleus ; G-protein alpha-subunit binding ; negative regulation of signal transduction


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cytosol ; nucleoplasm ; K63-linked polyubiquitin modification-dependent protein binding ; metal ion binding ; polyubiquitin modification-dependent protein binding ; protein kinase binding ; apoptotic process ; CD40 signaling pathway ; cellular response to lipopolysaccharide ; inflammatory response ; interleukin-1-mediated signaling pathway ; negative regulation of endothelial cell apoptotic process ; positive regulation of B cell activation ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of macrophage activation ; positive regulation of transcription by RNA polymerase II ; protein stabilization ; regulation of transcription by RNA polymerase II ; toll-like receptor 2 signaling pathway ; toll-like receptor 3 signaling pathway ; toll-like receptor 9 signaling pathway


Instruction: Predict the GO term based on the protein sequence.

Output: cytosol ; arginine binding ; identical protein binding ; molecular function inhibitor activity ; protein sequestering activity ; small molecule sensor activity ; cellular response to L-arginine ; negative regulation of TORC1 signaling ; positive regulation of TORC1 signaling


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: centrosome ; cytosol ; growth cone ; nucleoplasm ; plasma membrane


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: endoplasmic reticulum ; endoplasmic reticulum membrane ; membrane ; ABC-type transporter activity ; ATP binding ; ATP hydrolysis activity ; ATPase-coupled transmembrane transporter activity ; transmembrane transport


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: actin cytoskeleton ; centriole ; centrosome ; cytoplasm ; cytosol ; nucleoplasm ; plasma membrane ; microtubule binding ; ubiquitin protein ligase activity ; protein polyubiquitination ; protein stabilization ; protein ubiquitination ; regulation of centriole replication


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cytosol ; actin filament binding ; cadherin binding ; small GTPase binding ; cell migration ; cortical actin cytoskeleton organization ; cytoskeleton organization ; regulation of cell morphogenesis ; regulation of cell shape


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: basal plasma membrane ; basement membrane ; basolateral plasma membrane ; cell junction ; cytoplasm ; glutamatergic synapse ; hemidesmosome ; nuclear membrane ; nuclear speck ; nucleus ; plasma membrane ; postsynapse ; ErbB-2 class receptor binding ; signaling receptor binding ; structural constituent of cytoskeleton ; basal protein localization ; cell adhesion ; cellular response to tumor necrosis factor ; epidermal growth factor receptor signaling pathway ; establishment or maintenance of epithelial cell apical/basal polarity ; integrin-mediated signaling pathway ; intermediate filament cytoskeleton organization ; negative regulation of monocyte chemotactic protein-1 production ; negative regulation of NF-kappaB transcription factor activity ; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ; protein targeting ; regulation of postsynaptic membrane neurotransmitter receptor levels ; response to lipopolysaccharide ; response to muramyl dipeptide ; signal transduction


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: Golgi apparatus ; intracellular membrane-bounded organelle ; plasma membrane ; transport vesicle ; cell differentiation


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: histone methyltransferase complex ; MLL1/2 complex ; nucleoplasm ; nucleus ; histone H3K4 methyltransferase activity ; histone H3K4 monomethyltransferase activity ; unmethylated CpG binding ; zinc ion binding ; chromatin organization ; histone H3-K4 methylation ; positive regulation of DNA-templated transcription


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: chromatin ; nucleus ; DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ; protein dimerization activity ; protein homodimerization activity ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; sequence-specific DNA binding ; sequence-specific double-stranded DNA binding ; angiogenesis ; anterior/posterior pattern specification ; aorta morphogenesis ; artery morphogenesis ; blood vessel development ; blood vessel morphogenesis ; cell fate specification ; cell population proliferation ; cellular response to fibroblast growth factor stimulus ; cellular response to retinoic acid ; cochlea morphogenesis ; coronary artery morphogenesis ; determination of left/right symmetry ; ear morphogenesis ; embryonic cranial skeleton morphogenesis ; embryonic viscerocranium morphogenesis ; enamel mineralization ; epithelial cell differentiation ; face morphogenesis ; heart development ; heart morphogenesis ; inner ear morphogenesis ; lymph vessel development ; mesenchymal cell apoptotic process ; mesoderm development ; middle ear morphogenesis ; muscle cell fate commitment ; muscle organ development ; muscle organ morphogenesis ; muscle tissue morphogenesis ; negative regulation of cell differentiation ; negative regulation of mesenchymal cell apoptotic process ; neural crest cell migration ; odontogenesis of dentin-containing tooth ; outer ear morphogenesis ; outflow tract morphogenesis ; outflow tract septum morphogenesis ; parathyroid gland development ; pattern specification process ; pharyngeal system development ; positive regulation of cell population proliferation ; positive regulation of DNA-templated transcription ; positive regulation of epithelial cell proliferation ; positive regulation of MAPK cascade ; positive regulation of mesenchymal cell proliferation ; positive regulation of protein phosphorylation ; positive regulation of tongue muscle cell differentiation ; positive regulation of transcription by RNA polymerase II ; regulation of animal organ morphogenesis ; regulation of transcription by RNA polymerase II ; retinoic acid receptor signaling pathway ; semicircular canal morphogenesis ; sensory perception of sound ; social behavior ; soft palate development ; thymus development ; thyroid gland development ; tongue morphogenesis ; vagus nerve morphogenesis


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: cis-Golgi network ; COPI-coated vesicle membrane ; endoplasmic reticulum ; endoplasmic reticulum membrane ; Golgi membrane ; transport vesicle ; ER retention sequence binding ; KDEL sequence binding ; endoplasmic reticulum to Golgi vesicle-mediated transport ; protein retention in ER lumen ; protein transport ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: endoplasmic reticulum membrane ; intracellular membrane-bounded organelle ; membrane ; mitochondrion ; acyl-CoA delta5-desaturase activity ; C-5 sterol desaturase activity ; linoleoyl-CoA desaturase activity ; omega-6 fatty acid desaturase activity ; oxidoreductase activity ; oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water ; alpha-linolenic acid metabolic process ; cell-cell signaling ; cellular response to starvation ; icosanoid biosynthetic process ; linoleic acid metabolic process ; lipid metabolic process ; long-chain fatty acid biosynthetic process ; phospholipid biosynthetic process ; regulation of cell differentiation ; regulation of DNA-templated transcription ; unsaturated fatty acid biosynthetic process


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytoplasm ; cytosol ; extrinsic component of presynaptic endocytic zone membrane ; intracellular membrane-bounded organelle ; postsynaptic density ; vesicle ; clathrin binding ; protein tyrosine phosphatase activity ; SH3 domain binding ; clathrin-dependent endocytosis ; dephosphorylation ; regulation of clathrin-dependent endocytosis ; synaptic vesicle uncoating


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: apical dendrite ; dendritic spine ; perikaryon ; perinuclear region of cytoplasm ; plasma membrane ; postsynaptic density ; metal ion binding ; translation factor activity, non-nucleic acid binding ; ubiquitin protein ligase activity ; ubiquitin-protein transferase activity ; brain development ; cellular response to amino acid stimulus ; lactation ; negative regulation of cell population proliferation ; negative regulation of Notch signaling pathway ; nervous system development ; Notch signaling pathway ; positive regulation of apoptotic process ; positive regulation of dendritic spine development ; positive regulation of epidermal growth factor-activated receptor activity ; positive regulation of filopodium assembly ; positive regulation of long-term neuronal synaptic plasticity ; positive regulation of synapse maturation ; protein monoubiquitination ; skeletal muscle tissue development ; sperm axoneme assembly


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: ATF1-ATF4 transcription factor complex ; ATF4-CREB1 transcription factor complex ; chromatin ; nucleoplasm ; nucleus ; RNA polymerase II transcription regulator complex ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; identical protein binding ; protein-containing complex binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; cAMP-mediated signaling ; positive regulation of DNA replication ; positive regulation of neuron projection development ; positive regulation of transcription by RNA polymerase II ; protein-containing complex assembly ; regulation of transcription by RNA polymerase II ; response to cobalt ion ; response to purine-containing compound


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: cytoplasm ; plasma membrane ; cell adhesion ; cell-matrix adhesion ; immune response ; inflammatory response ; negative regulation of natural killer cell cytokine production ; negative regulation of type II interferon production ; response to lipopolysaccharide


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: apical plasma membrane ; basal plasma membrane ; basolateral plasma membrane ; cell body ; cell body membrane ; cell periphery ; cell projection ; cell projection membrane ; cytoplasmic vesicle membrane ; cytosol ; extracellular exosome ; extracellular vesicle ; lateral plasma membrane ; membrane ; neuron projection ; neuronal cell body ; plasma membrane ; ammonium transmembrane transporter activity ; chloride:monoatomic cation symporter activity ; Hsp90 protein binding ; metal ion transmembrane transporter activity ; potassium ion transmembrane transporter activity ; protein kinase binding ; protein-folding chaperone binding ; sodium:potassium:chloride symporter activity ; aging ; ammonium transmembrane transport ; cell volume homeostasis ; cellular response to chemokine ; cellular response to potassium ion ; chloride ion homeostasis ; chloride transmembrane transport ; gamma-aminobutyric acid signaling pathway ; hyperosmotic response ; inorganic anion import across plasma membrane ; inorganic cation import across plasma membrane ; intracellular chloride ion homeostasis ; intracellular potassium ion homeostasis ; intracellular sodium ion homeostasis ; maintenance of blood-brain barrier ; monoatomic ion transport ; negative regulation of vascular wound healing ; positive regulation of aspartate secretion ; positive regulation of cell volume ; potassium ion homeostasis ; potassium ion import across plasma membrane ; regulation of matrix metallopeptidase secretion ; regulation of spontaneous synaptic transmission ; sodium ion homeostasis ; sodium ion import across plasma membrane ; sodium ion transmembrane transport ; T cell chemotaxis ; transepithelial ammonium transport ; transepithelial chloride transport ; transport across blood-brain barrier


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytoplasm ; nucleus ; TORC2 complex ; leucine binding ; oxidoreductase activity, acting on peroxide as acceptor ; cellular response to amino acid starvation ; cellular response to glucose starvation ; cellular response to leucine ; cellular response to leucine starvation ; glucose homeostasis ; negative regulation of TORC1 signaling ; positive regulation of macroautophagy ; regulation of insulin receptor signaling pathway ; regulation of protein kinase B signaling ; regulation of response to reactive oxygen species ; response to insulin ; TORC2 signaling


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: chromatin ; cytoplasm ; nucleoplasm ; nucleus ; 14-3-3 protein binding ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; sequence-specific double-stranded DNA binding ; transcription cis-regulatory region binding ; canonical glycolysis ; cell differentiation ; intracellular glucose homeostasis ; muscle organ development ; negative regulation of autophagy ; negative regulation of DNA-templated transcription ; positive regulation of DNA-templated transcription ; regulation of glucose metabolic process ; regulation of transcription by RNA polymerase II ; response to starvation


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytosol ; intracellular membrane-bounded organelle ; peroxisome ; ATP binding ; identical protein binding ; magnesium ion binding ; mevalonate kinase activity ; cholesterol biosynthetic process ; isopentenyl diphosphate biosynthetic process, mevalonate pathway ; isoprenoid biosynthetic process ; negative regulation of inflammatory response ; phosphorylation


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: axon ; cell-cell junction ; focal adhesion ; neuronal cell body ; plasma membrane ; ATP binding ; axon guidance receptor activity ; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway ; protein kinase activity ; actin cytoskeleton reorganization ; axis elongation ; cell migration ; cellular response to retinoic acid ; cochlea morphogenesis ; convergent extension ; coronary vasculature development ; establishment of epithelial cell apical/basal polarity ; establishment of planar polarity ; homophilic cell adhesion via plasma membrane adhesion molecules ; kidney development ; lung-associated mesenchyme development ; planar cell polarity pathway involved in neural tube closure ; positive regulation of canonical Wnt signaling pathway ; positive regulation of neuron projection development ; protein phosphorylation ; signal transduction ; synapse organization ; ventricular septum development ; wound healing


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: nucleus ; ATP binding ; GTP binding ; metal ion binding ; nucleotidyltransferase activity ; anatomical structure morphogenesis ; camera-type eye development ; cell population proliferation ; eye development ; positive regulation of cell population proliferation


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: cell projection membrane ; clathrin-coated endocytic vesicle ; clathrin-coated endocytic vesicle membrane ; clathrin-coated pit ; cytosol ; endosome membrane ; extracellular exosome ; intercellular bridge ; melanosome ; plasma membrane ; recycling endosome membrane ; synaptic vesicle membrane ; GDP binding ; GTP binding ; GTPase activity ; phosphatidylinositol-4,5-bisphosphate binding ; antigen processing and presentation ; cellular response to nerve growth factor stimulus ; endocytic recycling ; endosomal transport ; mitotic cytokinesis ; neuron projection development ; plasma membrane to endosome transport ; protein localization ; protein localization to endosome ; protein transport ; Rab protein signal transduction


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: dendritic spine ; endosome membrane ; membrane ; plasma membrane ; postsynaptic density membrane ; recycling endosome membrane ; palmitoyl-(protein) hydrolase activity ; serine-type peptidase activity ; negative regulation of protein localization to microtubule ; positive regulation of protein localization to endosome ; protein depalmitoylation ; proteolysis ; regulation of dendritic spine maintenance ; regulation of protein localization to synapse


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: mitochondrion ; acyl-coenzyme A diphosphatase activity ; CoA pyrophosphatase activity ; magnesium ion binding ; manganese ion binding ; acetyl-CoA catabolic process ; butyryl-CoA catabolic process ; coenzyme A catabolic process ; malonyl-CoA catabolic process ; medium-chain fatty-acyl-CoA catabolic process ; propionyl-CoA catabolic process ; succinyl-CoA catabolic process


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytoplasm ; cytosol ; nucleolus ; plasma membrane ; ubiquitin ligase complex ; translation elongation factor activity


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytosol ; extracellular exosome ; intermediate filament ; structural molecule activity ; cornea development in camera-type eye ; epithelial cell differentiation ; intermediate filament organization ; morphogenesis of an epithelium ; visual perception


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: plasma membrane ; endopeptidase activator activity ; enzyme binding ; identical protein binding ; negative regulation of alpha-beta T cell activation ; negative regulation of CD4-positive, alpha-beta T cell proliferation ; negative regulation of CD8-positive, alpha-beta T cell proliferation ; negative regulation of interleukin-10 production ; negative regulation of interleukin-17 production ; negative regulation of tumor necrosis factor production ; negative regulation of type II interferon production ; positive regulation of cell migration ; positive regulation of collagen catabolic process ; positive regulation of endopeptidase activity ; positive regulation of gene expression ; positive regulation of regulatory T cell differentiation ; regulation of immune response ; zymogen activation


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: cytoplasm ; cytosol ; Golgi apparatus ; intracellular membrane-bounded organelle ; ATP binding ; Pyrin domain binding ; apoptotic process ; inflammatory response ; innate immune response ; negative regulation of NF-kappaB transcription factor activity ; negative regulation of NIK/NF-kappaB signaling ; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ; positive regulation of interleukin-1 beta production ; regulation of inflammatory response


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: external side of plasma membrane ; plasma membrane ; sperm head plasma membrane ; metalloendopeptidase activity ; metallopeptidase activity ; male gonad development ; proteolysis ; spermatogenesis


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: amphisome membrane ; autophagosome membrane ; cytoplasmic vesicle ; cytosol ; early endosome ; ESCRT III complex ; extracellular exosome ; kinetochore ; kinetochore microtubule ; late endosome ; lysosomal membrane ; midbody ; multivesicular body ; multivesicular body membrane ; nuclear pore ; plasma membrane ; identical protein binding ; molecular function inhibitor activity ; phosphatidylcholine binding ; phosphatidylinositol-4,5-bisphosphate binding ; ubiquitin-specific protease binding ; apoptotic process ; autophagosome maturation ; autophagy ; endosome transport via multivesicular body sorting pathway ; late endosome to lysosome transport ; late endosome to vacuole transport ; macroautophagy ; membrane fission ; midbody abscission ; mitotic metaphase plate congression ; multivesicular body assembly ; multivesicular body sorting pathway ; multivesicular body-lysosome fusion ; negative regulation of cell death ; nuclear membrane reassembly ; nucleus organization ; plasma membrane repair ; positive regulation of cytokinesis ; protein polymerization ; protein transport ; regulation of centrosome duplication ; regulation of early endosome to late endosome transport ; regulation of endosome size ; regulation of mitotic spindle assembly ; suppression of viral release by host ; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ; vesicle fusion with vacuole ; viral budding from plasma membrane ; viral budding via host ESCRT complex ; viral release from host cell


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: collagen-containing extracellular matrix ; extracellular matrix ; extracellular region ; matrilin complex ; calcium ion binding ; extracellular matrix structural constituent ; extracellular matrix organization


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: cytoplasm ; nucleoplasm ; nucleus ; DNA-binding transcription factor binding ; mRNA binding ; RNA binding ; transcription corepressor activity ; intracellular estrogen receptor signaling pathway ; mRNA processing ; negative regulation of DNA-templated transcription ; nervous system development ; regulation of alternative mRNA splicing, via spliceosome ; regulation of cell population proliferation ; RNA metabolic process ; RNA splicing


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: Golgi membrane ; plasma membrane ; heparan sulfate 6-O-sulfotransferase activity ; sulfotransferase activity ; angiogenesis ; heparan sulfate proteoglycan biosynthetic process, enzymatic modification ; labyrinthine layer blood vessel development ; lung alveolus development ; neuron development


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: apical part of cell ; basolateral plasma membrane ; cell surface ; clathrin-coated endocytic vesicle membrane ; clathrin-coated pit ; early endosome ; endolysosome membrane ; endosome membrane ; external side of plasma membrane ; Golgi apparatus ; late endosome ; low-density lipoprotein particle ; lysosome ; membrane ; PCSK9-LDLR complex ; plasma membrane ; receptor complex ; somatodendritic compartment ; sorting endosome ; amyloid-beta binding ; calcium ion binding ; clathrin heavy chain binding ; identical protein binding ; low-density lipoprotein particle binding ; low-density lipoprotein particle receptor activity ; molecular adaptor activity ; protease binding ; very-low-density lipoprotein particle receptor activity ; virus receptor activity ; amyloid-beta clearance ; amyloid-beta clearance by cellular catabolic process ; artery morphogenesis ; cellular response to fatty acid ; cellular response to low-density lipoprotein particle stimulus ; cholesterol homeostasis ; cholesterol import ; cholesterol metabolic process ; cholesterol transport ; endocytosis ; high-density lipoprotein particle clearance ; intestinal cholesterol absorption ; lipid metabolic process ; lipoprotein catabolic process ; long-term memory ; low-density lipoprotein particle clearance ; negative regulation of amyloid fibril formation ; negative regulation of astrocyte activation ; negative regulation of gene expression ; negative regulation of low-density lipoprotein particle clearance ; negative regulation of microglial cell activation ; negative regulation of protein metabolic process ; negative regulation of receptor recycling ; phagocytosis ; phospholipid transport ; plasma lipoprotein particle clearance ; positive regulation of gene expression ; positive regulation of inflammatory response ; positive regulation of lysosomal protein catabolic process ; positive regulation of triglyceride biosynthetic process ; receptor-mediated endocytosis ; receptor-mediated endocytosis involved in cholesterol transport ; regulation of cholesterol metabolic process ; regulation of phosphatidylcholine catabolic process ; regulation of protein metabolic process ; response to caloric restriction


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Input: MYGKIIFVLLLSEIVSISASSTTGVAMHTSTSSSVTKSYISSQTNDTHKRDTYAATPRAHEVSEISVRTVYPPEEETGERVQLAHHFSEPEITLIIFGVMAGVIGTILLISYGIRRLIKKSPSDVKPLPSPDTDVPLSSVEIENPETSDQ

Output: cytosol ; membrane ; nucleoplasm ; plasma membrane ; identical protein binding ; virus receptor activity


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: nucleus ; DNA binding ; metal ion binding ; regulation of DNA-templated transcription


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cytoplasmic vesicle membrane ; Golgi membrane ; plasma membrane ; transport vesicle membrane ; metal ion binding ; metalloendopeptidase activity ; methyltransferase activity ; cell-cell signaling ; G protein-coupled receptor signaling pathway ; methylation ; peptide hormone processing ; protein processing


Instruction: Given a protein sequence, predict the Gene Ontology term that describes its attributes in terms of molecular function, biological process, and cellular component.

Output: actin cytoskeleton ; cytoplasm ; cytoplasmic vesicle ; cytosol ; extracellular region ; Golgi apparatus ; Golgi membrane ; plasma membrane ; symbiont cell surface ; vesicle membrane ; actin binding ; cytokine binding ; enzyme binding ; G protein activity ; GDP binding ; GDP phosphatase activity ; GTP binding ; GTPase activity ; Hsp90 protein binding ; identical protein binding ; protein homodimerization activity ; spectrin binding ; canonical inflammasome complex assembly ; cellular response to interleukin-1 ; cellular response to tumor necrosis factor ; cellular response to type II interferon ; cytolysis in another organism ; defense response to bacterium ; defense response to protozoan ; defense response to virus ; innate immune response ; negative regulation of ERK1 and ERK2 cascade ; negative regulation of interleukin-2 production ; negative regulation of protein localization to plasma membrane ; negative regulation of substrate adhesion-dependent cell spreading ; negative regulation of T cell receptor signaling pathway ; positive regulation of pyroptosis ; protein localization to vacuole ; regulation of calcium-mediated signaling ; regulation of protein localization to plasma membrane


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: cytoplasm ; nuclear membrane ; plasma membrane ; ATP binding ; GTP binding ; identical protein binding ; metal ion binding ; protein heterodimerization activity ; protein homodimerization activity ; selenide, water dikinase activity ; phosphorylation ; protein modification process ; selenocysteine biosynthetic process


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: apical plasma membrane ; external side of plasma membrane ; extracellular exosome ; nucleoplasm ; plasma membrane ; sodium channel complex ; ligand-gated sodium channel activity ; monoatomic ion channel activity ; sodium channel activity ; WW domain binding ; cellular response to acidic pH ; cellular response to aldosterone ; cellular response to amiloride ; cellular response to vasopressin ; intracellular sodium ion homeostasis ; multicellular organismal-level water homeostasis ; regulation of blood pressure ; sensory perception of salty taste ; sensory perception of sour taste ; sodium ion homeostasis ; sodium ion import across plasma membrane ; sodium ion transmembrane transport ; sodium ion transport


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: external side of plasma membrane ; extracellular space ; membrane ; plasma membrane ; receptor complex ; cytokine binding ; cytokine receptor activity ; interleukin-5 receptor activity ; cytokine-mediated signaling pathway ; inflammatory response to antigenic stimulus ; interleukin-5-mediated signaling pathway ; positive regulation of leukocyte proliferation ; regulation of interleukin-5 production ; signal transduction


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytoplasm ; cytosol ; mitochondrion ; nucleoplasm ; nucleus ; transcription regulator complex ; DNA binding ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; miRNA binding ; RNA binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; sequence-specific DNA binding ; sequence-specific double-stranded DNA binding ; transcription cis-regulatory region binding ; ubiquitin protein ligase binding ; anatomical structure morphogenesis ; blastocyst development ; BMP signaling pathway involved in heart induction ; cardiac cell fate determination ; cell fate commitment involved in formation of primary germ layer ; endodermal cell fate specification ; negative regulation of miRNA transcription ; negative regulation of miRNA-mediated gene silencing ; negative regulation of transcription by RNA polymerase II ; positive regulation of canonical Wnt signaling pathway ; positive regulation of SMAD protein signal transduction ; positive regulation of transcription by RNA polymerase II ; regulation of asymmetric cell division ; regulation of DNA methylation-dependent heterochromatin formation ; regulation of DNA-templated transcription ; regulation of gene expression ; regulation of heart induction by regulation of canonical Wnt signaling pathway ; regulation of transcription by RNA polymerase II ; response to wounding ; somatic stem cell population maintenance


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: extracellular exosome ; extracellular region ; platelet dense granule lumen ; endopeptidase inhibitor activity ; serine-type endopeptidase inhibitor activity ; hyaluronan metabolic process ; negative regulation of peptidase activity


Instruction: Provide the Gene Ontology term that matches the characteristics of a given protein sequence.

Output: apical part of cell ; axonal growth cone ; caveola ; ciliary membrane ; dendritic growth cone ; endocytic vesicle membrane ; intracellular membrane-bounded organelle ; midbody ; nucleus ; perinuclear region of cytoplasm ; plasma membrane ; postsynaptic density ; cholesterol binding ; cyclin binding ; hedgehog family protein binding ; hedgehog receptor activity ; heparin binding ; patched binding ; protein-containing complex binding ; smoothened binding ; animal organ morphogenesis ; brain development ; branching involved in ureteric bud morphogenesis ; cell differentiation involved in kidney development ; cell fate determination ; cell proliferation involved in metanephros development ; cellular response to cholesterol ; commissural neuron axon guidance ; dorsal/ventral neural tube patterning ; dorsal/ventral pattern formation ; embryonic limb morphogenesis ; embryonic organ development ; epidermal cell fate specification ; glucose homeostasis ; heart morphogenesis ; hindlimb morphogenesis ; in utero embryonic development ; keratinocyte proliferation ; limb morphogenesis ; liver regeneration ; mammary gland duct morphogenesis ; mammary gland epithelial cell differentiation ; metanephric collecting duct development ; negative regulation of cell division ; negative regulation of DNA-binding transcription factor activity ; negative regulation of keratinocyte proliferation ; negative regulation of multicellular organism growth ; negative regulation of osteoblast differentiation ; negative regulation of smoothened signaling pathway ; negative regulation of stem cell proliferation ; negative regulation of transcription by RNA polymerase II ; neural plate axis specification ; neural tube closure ; neural tube patterning ; pharyngeal system development ; positive regulation of cholesterol efflux ; positive regulation of DNA-templated transcription ; positive regulation of epidermal cell differentiation ; prostate gland development ; protein localization to plasma membrane ; protein processing ; regulation of mitotic cell cycle ; regulation of protein localization ; regulation of smoothened signaling pathway ; response to chlorate ; response to estradiol ; response to mechanical stimulus ; response to retinoic acid ; response to xenobiotic stimulus ; smooth muscle tissue development ; smoothened signaling pathway ; somite development ; spermatid development ; spinal cord motor neuron differentiation ; stem cell proliferation


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: elongin complex ; extracellular space ; nucleoplasm ; site of DNA damage ; regulation of transcription by RNA polymerase II ; transcription elongation by RNA polymerase II ; transcription initiation at RNA polymerase II promoter


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: nucleus ; DNA binding ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; metal ion binding ; negative regulation of transcription by RNA polymerase II


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: centrosome ; chromosome, centromeric region ; condensed chromosome, centromeric region ; cytosol ; kinetochore ; nucleoplasm ; spindle pole ; kinase binding ; attachment of spindle microtubules to kinetochore ; cell division ; centriole-centriole cohesion ; chromosome segregation ; meiotic chromosome segregation ; mitotic sister chromatid cohesion, centromeric ; mitotic sister chromatid segregation


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: extracellular matrix ; extracellular space ; membrane ; protein phosphatase inhibitor activity


Instruction: Predict the GO term based on the protein sequence.

Output: chromatin ; chromosome ; site of double-strand break ; DNA repair ; negative regulation of double-strand break repair via homologous recombination ; positive regulation of double-strand break repair via nonhomologous end joining ; positive regulation of isotype switching ; somatic diversification of immunoglobulins involved in immune response ; telomere maintenance in response to DNA damage


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: cytoplasm ; ficolin-1-rich granule membrane ; plasma membrane ; secretory granule membrane ; positive regulation of MAPK cascade ; Ras protein signal transduction ; transmembrane receptor protein tyrosine kinase signaling pathway


Instruction: Determine the GO term that accurately describes the attributes of a given protein sequence.

Output: cytosol ; peroxisomal membrane ; peroxisome ; ATPase binding ; protein-containing complex binding ; protein-membrane adaptor activity ; protein import into peroxisome matrix ; protein import into peroxisome membrane ; protein to membrane docking


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: cell surface ; collagen-containing extracellular matrix ; extracellular matrix ; extracellular space ; endopeptidase activity ; extracellular matrix binding ; heparin binding ; metalloendopeptidase activity ; zinc ion binding ; extracellular matrix disassembly ; extracellular matrix organization ; myoblast fusion ; proteolysis


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: cell-cell junction ; cytoplasm ; cytoskeleton ; cytosol ; lamellipodium membrane ; ruffle membrane ; heat shock protein binding ; magnesium ion binding ; myosin phosphatase activity ; phosphoprotein phosphatase activity ; protein homodimerization activity ; pyridoxal phosphatase activity ; actin rod assembly ; cellular response to ATP ; dephosphorylation ; positive regulation of actin filament depolymerization ; protein dephosphorylation ; pyridoxal phosphate catabolic process ; regulation of cytokinesis ; regulation of mitotic nuclear division


Instruction: Predict the specific Gene Ontology term that best represents the properties of a given protein sequence.

Output: endoplasmic reticulum membrane ; GPI-anchor transamidase complex ; membrane ; attachment of GPI anchor to protein


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: CMG complex ; GINS complex ; nucleoplasm ; nucleus ; DNA unwinding involved in DNA replication ; mitotic DNA replication initiation ; positive regulation of DNA primase activity ; positive regulation of DNA-directed DNA polymerase activity


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: chromatin ; RNA polymerase II transcription regulator complex ; DNA-binding transcription factor activity, RNA polymerase II-specific ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; protein dimerization activity ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; regulation of transcription by RNA polymerase II


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cytosol ; early endosome membrane ; endoplasmic reticulum membrane ; intracellular membrane-bounded organelle ; nuclear membrane ; perinuclear endoplasmic reticulum ; plasma membrane ; cholesterol binding ; sterol transporter activity ; bile acid biosynthetic process ; regulation of cholesterol transport


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: U1 snRNP ; U2-type prespliceosome ; identical protein binding ; mRNA binding ; RS domain binding ; mRNA splice site selection ; negative regulation of striated muscle tissue development


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: Golgi membrane ; membrane ; beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity ; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity ; axon guidance ; cellular response to leukemia inhibitory factor ; keratan sulfate biosynthetic process ; O-glycan processing ; poly-N-acetyllactosamine biosynthetic process ; protein O-linked glycosylation ; sensory perception of smell


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: cytosol ; molybdopterin synthase complex ; nucleus ; 4 iron, 4 sulfur cluster binding ; cyclic pyranopterin monophosphate synthase activity ; GTP 3',8'-cyclase activity ; GTP binding ; metal ion binding ; Mo-molybdopterin cofactor biosynthetic process


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Input: MTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTILLLNFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGDYFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGLLLTVLVALTYIVALLYEEPFTAEIYRQKASGSHKRS

Output: cytosol ; endoplasmic reticulum ; endoplasmic reticulum membrane ; intracellular membrane-bounded organelle ; mitochondrial membrane ; mitochondrion ; phosphatidyl-N-dimethylethanolamine N-methyltransferase activity ; phosphatidyl-N-methylethanolamine N-methyltransferase activity ; phosphatidylethanolamine N-methyltransferase activity ; blastocyst hatching ; methylation ; phosphatidylcholine biosynthetic process ; positive regulation of cold-induced thermogenesis ; sphingomyelin biosynthetic process


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: external side of plasma membrane ; intracellular membrane-bounded organelle ; plasma membrane ; identical protein binding ; adaptive immune response ; autophagy ; defense response ; homophilic cell adhesion via plasma membrane adhesion molecules ; innate immune response ; negative regulation of granulocyte macrophage colony-stimulating factor production ; negative regulation of interleukin-18 production ; negative regulation of interleukin-6 production ; negative regulation of mast cell activation ; negative regulation of mast cell degranulation ; positive regulation of monocyte chemotactic protein-1 production ; positive regulation of tumor necrosis factor production ; regulation of macrophage activation ; regulation of store-operated calcium entry ; T cell activation


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; GABA receptor binding ; inositol 1,4,5 trisphosphate binding ; phosphatidylinositol phospholipase C activity ; B cell proliferation involved in immune response ; B-1a B cell differentiation ; gamma-aminobutyric acid signaling pathway ; intracellular signal transduction ; lipid metabolic process ; negative regulation of B cell receptor signaling pathway ; negative regulation of cold-induced thermogenesis ; positive regulation of receptor binding ; regulation of synaptic transmission, GABAergic


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: chromosome ; nucleolus ; nucleoplasm ; nucleus ; ATP binding ; protein kinase activity ; protein serine kinase activity ; protein serine/threonine kinase activity ; protein serine/threonine/tyrosine kinase activity ; protein tyrosine kinase activity ; transcription coactivator activity ; adipose tissue development ; DNA repair ; myoblast fusion ; peptidyl-serine phosphorylation ; peptidyl-threonine phosphorylation ; positive regulation of DNA-templated transcription ; protein autophosphorylation ; protein phosphorylation


Instruction: Find the Gene Ontology term that matches the attributes of a given protein sequence.

Output: axonemal microtubule ; centrosome ; cytosol ; ATP binding ; metal ion binding ; nucleoside diphosphate kinase activity ; CTP biosynthetic process ; GTP biosynthetic process ; phosphorylation ; UTP biosynthetic process


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: chromatin ; nucleus ; DNA-binding transcription factor activity, RNA polymerase II-specific ; DNA-binding transcription repressor activity, RNA polymerase II-specific ; metal ion binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; negative regulation of transcription by RNA polymerase II ; regulation of transcription by RNA polymerase II


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: endoplasmic reticulum ; endoplasmic reticulum membrane ; membrane raft ; protein-containing complex ; cholesterol binding ; ubiquitin protein ligase binding ; cholesterol metabolic process ; negative regulation of cholesterol biosynthetic process ; negative regulation of fatty acid biosynthetic process ; regulation of cholesterol biosynthetic process ; SREBP signaling pathway ; ubiquitin-dependent ERAD pathway


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: B-WICH complex ; catalytic step 2 spliceosome ; nuclear speck ; nucleolus ; nucleoplasm ; nucleus ; spliceosomal complex ; U11/U12 snRNP ; U12-type spliceosomal complex ; U2 snRNP ; U2-type precatalytic spliceosome ; U2-type prespliceosome ; U2-type spliceosomal complex ; mRNA binding ; RNA binding ; splicing factor binding ; chromatin remodeling ; mRNA splicing, via spliceosome ; positive regulation of histone acetylation ; positive regulation of transcription by RNA polymerase I ; positive regulation of transcription by RNA polymerase II ; positive regulation of transcription by RNA polymerase III ; RNA splicing ; RNA splicing, via transesterification reactions ; spliceosomal complex assembly ; U2-type prespliceosome assembly


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: ATF4-CREB1 transcription factor complex ; chromatin ; euchromatin ; nucleoplasm ; nucleus ; RNA polymerase II transcription regulator complex ; cAMP response element binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; enzyme binding ; identical protein binding ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; sequence-specific double-stranded DNA binding ; axonogenesis ; cAMP-mediated signaling ; cellular response to forskolin ; cellular response to hepatocyte growth factor stimulus ; cellular response to leukemia inhibitory factor ; cellular response to retinoic acid ; cellular response to zinc ion ; circadian rhythm ; hormone secretion ; lactation ; lung saccule development ; memory ; mRNA transcription by RNA polymerase II ; negative regulation of transcription by competitive promoter binding ; osteoclast differentiation ; pituitary gland development ; positive regulation of cardiac muscle tissue development ; positive regulation of DNA-templated transcription ; positive regulation of fat cell differentiation ; positive regulation of hormone secretion ; positive regulation of lipid biosynthetic process ; positive regulation of multicellular organism growth ; positive regulation of osteoclast differentiation ; positive regulation of transcription by RNA polymerase II ; protein phosphorylation ; protein stabilization ; regulation of cell size ; regulation of transcription by RNA polymerase II ; response to glucagon ; response to organic substance ; response to purine-containing compound ; response to xenobiotic stimulus ; secretory granule organization ; signal transduction ; type I pneumocyte differentiation


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: chromatin ; chromosome, telomeric region ; ERCC4-ERCC1 complex ; nucleolus ; nucleoplasm ; nucleus ; site of DNA damage ; 3' overhang single-stranded DNA endodeoxyribonuclease activity ; ADP-D-ribose modification-dependent protein binding ; enzyme binding ; oxidized DNA binding ; poly-ADP-D-ribose binding ; base-excision repair ; cerebellum morphogenesis ; double-strand break repair via nonhomologous end joining ; hippocampus development ; negative regulation of protection from non-homologous end joining at telomere ; negative regulation of protein ADP-ribosylation ; positive regulation of DNA ligase activity ; positive regulation of single strand break repair ; replication-born double-strand break repair via sister chromatid exchange ; response to hydroperoxide ; response to hypoxia ; response to organic substance ; response to xenobiotic stimulus ; single strand break repair ; telomeric DNA-containing double minutes formation ; voluntary musculoskeletal movement


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: cell cortex ; cell-cell junction ; ciliary basal body ; cytoplasm ; cytosol ; glutamatergic synapse ; lamellipodium ; microtubule cytoskeleton ; mitochondrion ; nucleoplasm ; nucleus ; plasma membrane ; postsynapse ; protein-containing complex ; spindle ; vesicle ; 14-3-3 protein binding ; ATP binding ; calmodulin binding ; enzyme binding ; enzyme inhibitor activity ; identical protein binding ; kinase activity ; nitric-oxide synthase regulator activity ; phosphatidylinositol-3,4,5-trisphosphate binding ; phosphatidylinositol-3,4-bisphosphate binding ; potassium channel activator activity ; protein homodimerization activity ; protein kinase activator activity ; protein kinase activity ; protein kinase binding ; protein serine kinase activity ; protein serine/threonine kinase activity ; protein serine/threonine kinase inhibitor activity ; protein serine/threonine/tyrosine kinase activity ; activation-induced cell death of T cells ; anoikis ; apoptotic mitochondrial changes ; behavioral response to pain ; carbohydrate transport ; cell differentiation ; cell migration involved in sprouting angiogenesis ; cell population proliferation ; cellular response to cadmium ion ; cellular response to decreased oxygen levels ; cellular response to epidermal growth factor stimulus ; cellular response to granulocyte macrophage colony-stimulating factor stimulus ; cellular response to insulin stimulus ; cellular response to nerve growth factor stimulus ; cellular response to oxidised low-density lipoprotein particle stimulus ; cellular response to prostaglandin E stimulus ; cellular response to reactive oxygen species ; cellular response to tumor necrosis factor ; cellular response to vascular endothelial growth factor stimulus ; cytokine-mediated signaling pathway ; epidermal growth factor receptor signaling pathway ; establishment of protein localization to mitochondrion ; excitatory postsynaptic potential ; execution phase of apoptosis ; fibroblast migration ; G protein-coupled receptor signaling pathway ; gene expression ; germ cell development ; glucose homeostasis ; glucose metabolic process ; glycogen biosynthetic process ; glycogen cell differentiation involved in embryonic placenta development ; I-kappaB kinase/NF-kappaB signaling ; inflammatory response ; insulin receptor signaling pathway ; insulin-like growth factor receptor signaling pathway ; interleukin-18-mediated signaling pathway ; intracellular signal transduction ; labyrinthine layer blood vessel development ; lipopolysaccharide-mediated signaling pathway ; maintenance of protein location in mitochondrion ; mammary gland epithelial cell differentiation ; maternal placenta development ; mitigation of host antiviral defense response ; negative regulation of apoptotic process ; negative regulation of autophagy ; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ; negative regulation of endopeptidase activity ; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ; negative regulation of fatty acid beta-oxidation ; negative regulation of gene expression ; negative regulation of innate immune response ; negative regulation of leukocyte cell-cell adhesion ; negative regulation of long-chain fatty acid import across plasma membrane ; negative regulation of lymphocyte migration ; negative regulation of macroautophagy ; negative regulation of neuron death ; negative regulation of Notch signaling pathway ; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ; negative regulation of protein binding ; negative regulation of protein kinase activity ; negative regulation of protein serine/threonine kinase activity ; negative regulation of protein ubiquitination ; negative regulation of proteolysis ; negative regulation of release of cytochrome c from mitochondria ; NIK/NF-kappaB signaling ; nitric oxide biosynthetic process ; osteoblast differentiation ; peptidyl-serine phosphorylation ; peptidyl-threonine phosphorylation ; peripheral nervous system myelin maintenance ; phosphatidylinositol 3-kinase signaling ; phosphorylation ; positive regulation of blood vessel endothelial cell migration ; positive regulation of cell growth ; positive regulation of cell population proliferation ; positive regulation of cyclin-dependent protein serine/threonine kinase activity ; positive regulation of DNA-binding transcription factor activity ; positive regulation of DNA-templated transcription ; positive regulation of endodeoxyribonuclease activity ; positive regulation of endothelial cell migration ; positive regulation of endothelial cell proliferation ; positive regulation of fat cell differentiation ; positive regulation of fibroblast migration ; positive regulation of G1/S transition of mitotic cell cycle ; positive regulation of gene expression ; positive regulation of glucose import ; positive regulation of glucose metabolic process ; positive regulation of glycogen biosynthetic process ; positive regulation of I-kappaB phosphorylation ; positive regulation of lipid biosynthetic process ; positive regulation of mitochondrial membrane potential ; positive regulation of nitric oxide biosynthetic process ; positive regulation of nitric-oxide synthase activity ; positive regulation of organ growth ; positive regulation of peptidyl-serine phosphorylation ; positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; positive regulation of protein localization to cell surface ; positive regulation of protein localization to endoplasmic reticulum ; positive regulation of protein localization to nucleus ; positive regulation of protein localization to plasma membrane ; positive regulation of protein metabolic process ; positive regulation of protein phosphorylation ; positive regulation of smooth muscle cell proliferation ; positive regulation of sodium ion transport ; positive regulation of TORC1 signaling ; positive regulation of transcription by RNA polymerase II ; proteasome-mediated ubiquitin-dependent protein catabolic process ; protein autophosphorylation ; protein import into nucleus ; protein kinase B signaling ; protein phosphorylation ; protein ubiquitination ; regulation of apoptotic process ; regulation of cell migration ; regulation of glycogen biosynthetic process ; regulation of mRNA stability ; regulation of myelination ; regulation of neuron projection development ; regulation of postsynapse organization ; regulation of signal transduction by p53 class mediator ; regulation of translation ; regulation of tRNA methylation ; regulation of type B pancreatic cell development ; response to fluid shear stress ; response to food ; response to growth factor ; response to growth hormone ; response to heat ; response to insulin-like growth factor stimulus ; response to oxidative stress ; response to UV-A ; signal transduction ; sphingosine-1-phosphate receptor signaling pathway ; striated muscle cell differentiation ; T cell costimulation ; TOR signaling


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytoplasm ; cytosol ; extracellular exosome ; nucleus ; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity ; 5alpha-androstane-3beta,17beta-diol dehydrogenase activity ; alditol:NADP+ 1-oxidoreductase activity ; aldo-keto reductase (NADP) activity ; androstan-3-alpha,17-beta-diol dehydrogenase activity ; androsterone dehydrogenase activity ; bile acid binding ; delta4-3-oxosteroid 5beta-reductase activity ; dihydrotestosterone 17-beta-dehydrogenase activity ; estradiol 17-beta-dehydrogenase  activity ; geranylgeranyl reductase activity ; ketoreductase activity ; ketosteroid monooxygenase activity ; NAD-retinol dehydrogenase activity ; NADP-retinol dehydrogenase activity ; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ; phenanthrene 9,10-monooxygenase activity ; prostaglandin D2 11-ketoreductase activity ; prostaglandin H2 endoperoxidase reductase activity ; prostaglandin-F synthase activity ; retinal dehydrogenase activity ; testosterone 17-beta-dehydrogenase (NADP+) activity ; testosterone dehydrogenase (NAD+) activity ; cellular response to cadmium ion ; cellular response to calcium ion ; cellular response to corticosteroid stimulus ; cellular response to jasmonic acid stimulus ; cellular response to prostaglandin D stimulus ; cellular response to prostaglandin stimulus ; cellular response to reactive oxygen species ; cellular response to starvation ; cyclooxygenase pathway ; daunorubicin metabolic process ; doxorubicin metabolic process ; farnesol catabolic process ; G protein-coupled receptor signaling pathway ; keratinocyte differentiation ; macromolecule metabolic process ; male gonad development ; negative regulation of retinoic acid biosynthetic process ; positive regulation of cell death ; positive regulation of cell population proliferation ; positive regulation of endothelial cell apoptotic process ; positive regulation of protein kinase B signaling ; positive regulation of reactive oxygen species metabolic process ; progesterone metabolic process ; prostaglandin metabolic process ; regulation of retinoic acid receptor signaling pathway ; regulation of testosterone biosynthetic process ; renal absorption ; response to nutrient ; retinal metabolic process ; retinoid metabolic process ; steroid metabolic process ; testosterone biosynthetic process


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: cytosol ; dendrite ; extracellular region ; plasma membrane ; ATP binding ; axon guidance receptor activity ; ephrin receptor activity ; transmembrane-ephrin receptor activity ; angiogenesis ; axon guidance ; axonal fasciculation ; cell migration ; central nervous system projection neuron axonogenesis ; corpus callosum development ; dendritic spine development ; dendritic spine morphogenesis ; digestive tract morphogenesis ; ephrin receptor signaling pathway ; positive regulation of synapse assembly ; protein autophosphorylation ; regulation of axonogenesis ; regulation of cell-cell adhesion ; regulation of GTPase activity ; retinal ganglion cell axon guidance ; roof of mouth development ; substrate adhesion-dependent cell spreading ; thymus development ; urogenital system development


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytosol ; extracellular region ; extracellular space ; ficolin-1-rich granule lumen ; membrane ; NLRP3 inflammasome complex ; nucleoplasm ; plasma membrane ; specific granule lumen ; tertiary granule lumen ; cardiolipin binding ; phosphatidic acid binding ; phosphatidylinositol-4,5-bisphosphate binding ; phosphatidylinositol-4-phosphate binding ; phosphatidylserine binding ; wide pore channel activity ; cellular response to extracellular stimulus ; defense response to bacterium ; defense response to Gram-negative bacterium ; defense response to Gram-positive bacterium ; inflammatory response ; innate immune response ; pore complex assembly ; positive regulation of inflammatory response ; positive regulation of interleukin-1 beta production ; positive regulation of interleukin-1 production ; positive regulation of interleukin-18 production ; protein homooligomerization ; protein secretion ; pyroptosis


Instruction: The Gene Ontology project (GO) provides a controlled vocabulary to describe gene and gene product attributes in any organism. There are 3 disjoint categories: cellular component, molecular function and biological process. Predict the GO term for a given protein sequence.

Output: plasma membrane ; myoblast fusion ; syncytium formation ; syncytium formation by plasma membrane fusion


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: cytosol ; nucleolus ; ATP binding ; negative regulation of NF-kappaB transcription factor activity ; positive regulation of gene expression


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Input: MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTYNN

Output: cytoplasm ; extracellular exosome ; nucleoplasm ; nucleus ; UBC13-MMS2 complex ; DNA double-strand break processing ; error-free postreplication DNA repair ; positive regulation of double-strand break repair ; positive regulation of protein K63-linked ubiquitination ; postreplication repair ; protein K63-linked ubiquitination ; protein polyubiquitination ; protein ubiquitination ; regulation of DNA repair


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytoplasm ; cytoplasmic ribonucleoprotein granule ; extracellular space ; intermediate filament ; neurofilament ; postsynaptic intermediate filament cytoskeleton ; Schaffer collateral - CA1 synapse ; structural constituent of cytoskeleton ; structural constituent of postsynaptic intermediate filament cytoskeleton ; cell differentiation ; cellular response to leukemia inhibitory factor ; intermediate filament organization ; neurofilament cytoskeleton organization ; postsynaptic modulation of chemical synaptic transmission ; substantia nigra development


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: mitochondrial matrix ; mitochondrion ; ATP binding ; protein kinase activity ; pyruvate dehydrogenase (acetyl-transferring) kinase activity ; cellular response to fatty acid ; cellular response to starvation ; glucose homeostasis ; glucose metabolic process ; insulin receptor signaling pathway ; negative regulation of anoikis ; protein phosphorylation ; reactive oxygen species metabolic process ; regulation of acetyl-CoA biosynthetic process from pyruvate ; regulation of bone resorption ; regulation of cellular ketone metabolic process ; regulation of fatty acid biosynthetic process ; regulation of fatty acid oxidation ; regulation of glucose metabolic process ; regulation of pH ; response to starvation


Instruction: Determine the Gene Ontology term that best describes the attributes of a given protein sequence.

Output: cytosol ; nucleus ; carbohydrate binding ; galactoside binding ; negative regulation of CD4-positive, alpha-beta T cell proliferation ; negative regulation of type II interferon production ; positive regulation of gene expression


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: endoplasmic reticulum lumen ; membrane ; procollagen galactosyltransferase activity ; collagen fibril organization ; positive regulation of collagen fibril organization


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: cytosol ; lyase activity ; Mo-molybdopterin cofactor sulfurase activity ; molybdenum cofactor sulfurtransferase activity ; molybdenum ion binding ; pyridoxal phosphate binding ; Mo-molybdopterin cofactor biosynthetic process ; molybdopterin cofactor biosynthetic process ; molybdopterin cofactor metabolic process


Instruction: Given a protein sequence, predict the corresponding Gene Ontology term that describes its molecular function, biological process, and cellular component.

Output: plasma membrane ; voltage-gated potassium channel activity ; potassium ion transmembrane transport ; regulation of membrane potential ; regulation of monoatomic ion transmembrane transport


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: cytosol ; fibrillar center ; histone deacetylase complex ; nucleoplasm ; nucleus ; transcription regulator complex ; DNA binding ; metal ion binding ; nuclear progesterone receptor binding ; nuclear receptor coactivator activity ; transcription coactivator activity ; transcription coactivator binding ; transcription corepressor activity ; cellular response to progesterone stimulus ; negative regulation of DNA-templated transcription ; positive regulation of DNA-templated transcription ; positive regulation of transcription by RNA polymerase II ; progesterone receptor signaling pathway ; regulation of transcription by RNA polymerase II


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Output: cytoplasmic vesicle ; nucleus ; Swr1 complex ; histone binding ; histone chaperone activity ; phosphatase inhibitor activity ; protein folding chaperone ; chromatin organization ; regulation of apoptotic process


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: Cajal body ; chromosome, telomeric region ; cytosol ; nuclear body ; nucleoplasm ; site of double-strand break ; telomerase holoenzyme complex ; histone binding ; identical protein binding ; protein-containing complex binding ; protein-folding chaperone binding ; RNA binding ; telomerase RNA binding ; ubiquitin protein ligase binding ; Cajal body organization ; DNA repair ; positive regulation of DNA repair ; positive regulation of double-strand break repair ; positive regulation of double-strand break repair via homologous recombination ; positive regulation of double-strand break repair via nonhomologous end joining ; positive regulation of establishment of protein localization to telomere ; positive regulation of telomerase activity ; protein localization to Cajal body ; RNA folding ; scaRNA localization to Cajal body ; telomerase RNA localization to Cajal body ; telomere formation via telomerase ; telomere maintenance via telomerase


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Input: MVNSCCGSVCSDQGCGLENCCRPSYCQTTCCRTTCCRPSCCVSSCCRPQCCQTTCCRTTCCHPSCCVSSCCRPQCCQSVCCQPTCCRPQCCQTTCCRTTCCRPSCCRPQCCQSVCCQPTCCCPSYCVSSCCRPQCCQTTCCRTTCCRPSCCVSRCYRPHCGQSLCC

Output: cytosol ; keratin filament


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: cytoplasm ; cytosol ; intercellular bridge ; microtubule cytoskeleton ; nucleoplasm ; nucleus ; plasma membrane ; ribonucleoprotein complex ; SCAR complex ; nuclear receptor coactivator activity ; steroid receptor RNA activator RNA binding ; transcription coactivator activity ; apoptotic process ; cell differentiation ; cellular response to estrogen stimulus ; negative regulation of myoblast differentiation ; regulation of apoptotic process ; regulation of mitotic cell cycle


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: centriole ; ciliary basal body ; gamma-tubulin complex ; midbody ; nuclear speck ; nucleoplasm ; nucleus ; photoreceptor connecting cilium ; PML body ; spindle pole ; ubiquitin ligase complex ; antigen binding ; DNA binding ; DNA topoisomerase binding ; metal ion binding ; SUMO transferase activity ; ubiquitin protein ligase activity ; ubiquitin-protein transferase activity ; DNA damage response ; DNA-templated transcription ; intrinsic apoptotic signaling pathway in response to DNA damage ; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ; maintenance of protein location in nucleus ; negative regulation of apoptotic process ; photoreceptor cell outer segment organization ; positive regulation of DNA-templated transcription ; positive regulation of ubiquitin-protein transferase activity ; proteasome-mediated ubiquitin-dependent protein catabolic process ; protein K48-linked ubiquitination ; protein localization to nucleus ; protein monoubiquitination ; protein polyubiquitination ; protein sumoylation ; regulation of cell population proliferation ; retina layer formation ; retinal cone cell development ; retinal rod cell development ; ubiquitin-dependent protein catabolic process


Instruction: Predict the specific  Gene Ontology term that represents the characteristics of a given protein sequence.

Output: CD40 receptor complex ; cell cortex ; cytoplasm ; cytoplasmic side of plasma membrane ; cytosol ; endosome membrane ; extrinsic component of cytoplasmic side of plasma membrane ; lipid droplet ; nucleus ; perinuclear region of cytoplasm ; plasma membrane ; protein-containing complex ; histone deacetylase binding ; identical protein binding ; protein kinase B binding ; thioesterase binding ; tumor necrosis factor receptor binding ; tumor necrosis factor receptor superfamily binding ; ubiquitin conjugating enzyme binding ; ubiquitin protein ligase activity ; ubiquitin protein ligase binding ; ubiquitin-protein transferase activity ; ubiquitin-ubiquitin ligase activity ; zinc ion binding ; activation of NF-kappaB-inducing kinase activity ; activation of protein kinase activity ; antigen processing and presentation of exogenous peptide antigen via MHC class II ; bone resorption ; cellular response to cytokine stimulus ; cellular response to lipopolysaccharide ; cytosolic pattern recognition receptor signaling pathway ; DNA damage response ; Fc-epsilon receptor signaling pathway ; I-kappaB kinase/NF-kappaB signaling ; in utero embryonic development ; interleukin-1-mediated signaling pathway ; interleukin-17-mediated signaling pathway ; interleukin-17A-mediated signaling pathway ; lipopolysaccharide-mediated signaling pathway ; MyD88-dependent toll-like receptor signaling pathway ; myeloid dendritic cell differentiation ; negative regulation of DNA-templated transcription ; negative regulation of transcription by RNA polymerase II ; neural tube closure ; odontogenesis of dentin-containing tooth ; ossification ; osteoclast differentiation ; positive regulation of DNA-binding transcription factor activity ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of interleukin-12 production ; positive regulation of interleukin-2 production ; positive regulation of interleukin-6 production ; positive regulation of JNK cascade ; positive regulation of JUN kinase activity ; positive regulation of leukocyte adhesion to vascular endothelial cell ; positive regulation of lipopolysaccharide-mediated signaling pathway ; positive regulation of NF-kappaB transcription factor activity ; positive regulation of NIK/NF-kappaB signaling ; positive regulation of osteoclast differentiation ; positive regulation of protein ubiquitination ; positive regulation of T cell cytokine production ; positive regulation of T cell proliferation ; positive regulation of transcription by RNA polymerase II ; positive regulation of transcription regulatory region DNA binding ; protein autoubiquitination ; protein K63-linked ubiquitination ; protein polyubiquitination ; regulation of apoptotic process ; regulation of I-kappaB kinase/NF-kappaB signaling ; regulation of immunoglobulin production ; response to interleukin-1 ; stimulatory C-type lectin receptor signaling pathway ; T cell receptor signaling pathway ; T-helper 1 type immune response ; tumor necrosis factor-mediated signaling pathway


Instruction: Use the Gene Ontology project to assign the appropriate category for the molecular function, biological process, and cellular component of a given protein sequence.

Output: excitatory synapse ; extracellular space ; GABA-ergic synapse ; glutamatergic synapse ; hippocampal mossy fiber to CA3 synapse ; postsynaptic density membrane ; postsynaptic specialization membrane ; Schaffer collateral - CA1 synapse ; neurexin family protein binding ; long-term synaptic potentiation ; negative regulation of receptor internalization ; positive regulation of synapse assembly ; regulation of postsynaptic density assembly ; synapse organization


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: plasma membrane ; neuron projection development


Instruction: The Gene Ontology (GO) describes knowledge of the biological domain with respect to three aspects: Molecular function, Biological process, Cellular component. Predict the GO term for a given protein sequence.

Output: centriole ; ciliary basal body ; cilium ; cytoplasm ; cytoplasmic vesicle ; extracellular exosome ; Golgi apparatus ; nuclear body ; nucleoplasm ; periciliary membrane compartment ; plasma membrane ; GTP binding ; GTPase activator activity ; magnesium ion binding ; unfolded protein binding ; cilium assembly ; post-Golgi vesicle-mediated transport ; protein folding ; protein transport ; visual perception


Instruction: Predict the GO term based on the protein sequence.

Output: chromatin ; chromosome, telomeric region ; histone deacetylase complex ; membrane ; nucleoplasm ; nucleus ; NuRD complex ; protein-containing complex ; transcription regulator complex ; chromatin binding ; histone deacetylase activity ; histone deacetylase binding ; metal ion binding ; RNA polymerase II-specific DNA-binding transcription factor binding ; sequence-specific DNA binding ; transcription coactivator activity ; transcription corepressor activity ; chromatin organization ; chromatin remodeling ; DNA methylation ; histone deacetylation ; negative regulation of DNA-templated transcription ; negative regulation of transcription by RNA polymerase II ; positive regulation of DNA-templated transcription ; positive regulation of transcription by RNA polymerase II ; regulation of cell fate specification ; regulation of fibroblast migration ; regulation of stem cell differentiation


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: extracellular region ; extracellular space ; signaling receptor activity ; apoptotic process ; negative regulation of apoptotic process


Instruction: Analyze a protein sequence and provide the corresponding Gene Ontology term that best represents its properties.

Output: blood microparticle ; extracellular exosome ; extracellular region ; membrane attack complex ; complement binding ; retinol binding ; complement activation, alternative pathway ; complement activation, classical pathway ; killing of cells of another organism ; positive regulation of immune response


Instruction: Analyze a protein sequence and predict the Gene Ontology category that best represents its attributes.

Output: acrosomal membrane ; cytoplasmic vesicle ; cytosol ; endomembrane system ; endoplasmic reticulum membrane ; endosome to plasma membrane transport vesicle ; extracellular exosome ; Golgi apparatus ; Golgi membrane ; membrane ; plasma membrane ; secretory granule membrane ; trans-Golgi network ; trans-Golgi network membrane ; GTP binding ; GTPase activity ; myosin V binding ; protein domain specific binding ; antigen processing and presentation ; early endosome to Golgi transport ; intra-Golgi vesicle-mediated transport ; intracellular protein transport ; localization ; minus-end-directed organelle transport along microtubule ; neuron projection development ; peptidyl-cysteine methylation ; protein localization to Golgi apparatus ; protein localization to Golgi membrane ; retrograde transport, endosome to Golgi ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum


Instruction: Determine the GO term that accurately describes the gene and gene product attributes of a given protein sequence.

Output: extracellular exosome ; plasma membrane


Instruction: For a given protein sequence, identify the appropriate Gene Ontology term that corresponds to its molecular function, biological process, and cellular component.

Output: amylin receptor complex 1 ; amylin receptor complex 2 ; amylin receptor complex 3 ; axon ; plasma membrane ; amylin receptor activity ; amyloid-beta binding ; calcitonin binding ; calcitonin gene-related peptide receptor activity ; calcitonin receptor activity ; adenylate cyclase-activating G protein-coupled receptor signaling pathway ; amylin receptor signaling pathway ; cell surface receptor signaling pathway ; cross-receptor inhibition within G protein-coupled receptor heterodimer ; positive regulation of adenylate cyclase activity ; positive regulation of calcium ion import across plasma membrane ; positive regulation of cytosolic calcium ion concentration ; positive regulation of ERK1 and ERK2 cascade ; positive regulation of gene expression ; positive regulation of peptidyl-serine phosphorylation ; positive regulation of protein kinase A signaling ; positive regulation of protein kinase B signaling ; response to amyloid-beta ; response to glucocorticoid


Instruction: Identify the appropriate Gene Ontology term that corresponds to the molecular function, biological process, and cellular component of a given protein sequence.

Output: chromatin ; intracellular membrane-bounded organelle ; nucleoplasm ; nucleus ; RNA polymerase II transcription regulator complex ; DNA-binding transcription activator activity, RNA polymerase II-specific ; DNA-binding transcription factor activity, RNA polymerase II-specific ; RNA polymerase II cis-regulatory region sequence-specific DNA binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; sequence-specific DNA binding ; sequence-specific double-stranded DNA binding ; negative regulation of transcription by RNA polymerase II ; positive regulation of MHC class II biosynthetic process ; positive regulation of transcription by RNA polymerase II ; regulation of transcription by RNA polymerase II


Instruction: Use the Gene Ontology project to assign the appropriate term for the cellular component, molecular function, and biological process of a given protein sequence.

Input: MYSFMGGGLFCAWVGTILLVVAMATDHWMQYRLSGSFAHQGLWRYCLGNKCYLQTDSIAYWNATRAFMILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFSSTLFVVLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR

Output: cell junction ; plasma membrane ; vesicle ; structural constituent of eye lens ; cell-cell junction assembly ; lens development in camera-type eye