---
license: cc-by-nc-4.0
tags:
- biology
- protein
- antibody
- VHH
---

## VHHCorpus-2M

VHHCorpus-2M is a corpus that contains over two million full-length amino acid sequences of variable domain of heavy chain of heavy chain antibody (VHH).
We released VHHBERT, a VHH-specific language model pre-trained using VHHCorpus-2M on the [Hugging Face Hub](https://huggingface.co/COGNANO/VHHBERT).
Further details on VHHCorpus-2M are described in our paper "[A SARS-CoV-2 Interaction Dataset and VHH Sequence Corpus for Antibody Language Models](https://arxiv.org/abs/2405.18749).”

## Columns

| Column          | Description                                                                       |
| --------------- | --------------------------------------------------------------------------------- |
| VHH_sequence    | Amino acid sequence of VHH                                                        |
| subject_species | Species of the subject from which VHH was collected                               |
| subject_name    | Name of the subject from which VHH was collected                                  |
| subject_sex     | Sex of the subject from which VHH was collected                                   |

## Links

- Project Page: https://vhh-corpus.cognanous.com
- Code: https://github.com/cognano/AVIDa-SARS-CoV-2
- Pre-trained Model: https://huggingface.co/COGNANO/VHHBERT
- Paper: https://arxiv.org/abs/2405.18749

## Citation

If you use VHHCorpus-2M in your research, please cite the following paper.

```bibtex
@inproceedings{tsuruta2024sars,
  title={A {SARS}-{C}o{V}-2 Interaction Dataset and {VHH} Sequence Corpus for Antibody Language Models},
  author={Hirofumi Tsuruta and Hiroyuki Yamazaki and Ryota Maeda and Ryotaro Tamura and Akihiro Imura},
  booktitle={Advances in Neural Information Processing Systems 37},
  year={2024}
}
```