Lung Large Cell Neuroendocrine Carcinoma

Cough || Dyspnea || Fever || Hemoptysis || Rosette Formation || Aggressive Clinical Course || Trabecular Pattern || Sheet-Like Growth Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present


Endocrine Mucin-Producing Sweat Gland Carcinoma

Cribriform Pattern
Papillary Pattern
Solid Growth Pattern
Cystic Change

Cribriform Pattern || Papillary Pattern || Solid Growth Pattern || Cystic Change


Stage III Acral Lentiginous Melanoma AJCC v7

HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Testicular Yolk Sac Tumor, Myxomatous Pattern

Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body
Painless Testicular Mass

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body || Painless Testicular Mass


Abdominal Mass
Abdominal Pain
Jaundice
Nausea
Pruritus
Vomiting
Weight Loss

Abdominal Mass || Abdominal Pain || Jaundice || Nausea || Pruritus || Vomiting || Weight Loss


Metastatic Thyroid Gland Hurthle Cell Carcinoma

Tumor Vascular Invasion
Cold Nodule
Solid Growth Pattern
Trabecular Pattern
Capsular Invasion
Follicular Structures Present

Tumor Vascular Invasion || Cold Nodule || Solid Growth Pattern || Trabecular Pattern || Capsular Invasion || Follicular Structures Present

Dilated Thin-Walled Vascular Space Formation


Gallbladder Mucinous Cystic Neoplasm with an Associated Invasive Carcinoma


Lymphoepithelioid Variant Peripheral T-Cell Lymphoma

Aggressive Clinical Course
Diffuse Pattern
Interfollicular Pattern

Aggressive Clinical Course || Diffuse Pattern || Interfollicular Pattern


Hepatomegaly || Neoplastic Plasma Cells Present in Bone Marrow


Recurrent Poorly Differentiated Thyroid Gland Carcinoma

Cold Nodule
Insular Pattern
Solid Growth Pattern
Trabecular Pattern

Cold Nodule || Insular Pattern || Solid Growth Pattern || Trabecular Pattern


Atypical Melanocytic Nevus, Genital Type


HMB-45-Positive Neoplastic Cells Present


Salivary Gland Polymorphous Adenocarcinoma

Pain
Cribriform Pattern
Favorable Clinical Outcome
Papillary Pattern
Trabecular Pattern
Lobular Pattern

Pain || Cribriform Pattern || Favorable Clinical Outcome || Papillary Pattern || Trabecular Pattern || Lobular Pattern


Lymphadenopathy
Aggressive Clinical Course
Bulky Disease

Lymphadenopathy || Aggressive Clinical Course || Bulky Disease


Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome

FIP1L1-PDGFRalpha Fusion Protein Expression


EBV-Related Post-Transplant Lymphoproliferative Disorder


Primary Peritoneal Low Grade Serous Adenocarcinoma


Localized Disease
Favorable Clinical Outcome

Localized Disease || Favorable Clinical Outcome


Peutz-Jeghers Polyp of the Small Intestine


Acute Myeloid Leukemia with t(6;9) (p23;q34.1); DEK-NUP214

Basophilia
Bone Marrow Dysplasia Present
Hypercellular Bone Marrow
Unfavorable Clinical Outcome

Basophilia || Bone Marrow Dysplasia Present || Hypercellular Bone Marrow || Unfavorable Clinical Outcome


Apocrine Metaplasia
Microcalcification
Microcystic Change

Apocrine Metaplasia || Microcalcification || Microcystic Change


Childhood Unfavorable Prognosis Hodgkin Lymphoma


Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia

Anisochromasia
Chronic Clinical Course
Hypercellular Bone Marrow

Anisochromasia || Chronic Clinical Course || Hypercellular Bone Marrow


Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm


Refractory Transformed Chronic Lymphocytic Leukemia


Advanced Cutaneous Melanoma of the Extremity

HMB-45-Positive Neoplastic Cells Present


Intestinal T-Cell Lymphoma, Not Otherwise Specified


Hepatoblastoma with Pure Fetal Epithelial Differentiation

Abdominal Mass
Anorexia
Diaphragmatic Hernia
Jaundice
Meckel Diverticulum
Thrombocytosis
Weight Loss

Abdominal Mass || Anorexia || Diaphragmatic Hernia || Jaundice || Meckel Diverticulum || Thrombocytosis || Weight Loss


Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body


Stage IV Ovarian Teratoma AJCC v6 and v7

Abdominal Mass
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Abdominal Mass || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Pancreatic Poorly Cohesive Adenocarcinoma

Abdominal Pain
Jaundice
Pruritus
Weight Loss

Abdominal Pain || Jaundice || Pruritus || Weight Loss


Cytopenia
Erythroid Hyperplasia
Hepatomegaly
Splenomegaly
Megakaryocytes Increased in Bone Marrow
Leukocytosis
Thrombocytosis
Chronic Clinical Course
Hypercellular Bone Marrow
Granulocytes Increased in Bone Marrow

Cytopenia || Erythroid Hyperplasia || Hepatomegaly || Splenomegaly || Megakaryocytes Increased in Bone Marrow || Leukocytosis || Thrombocytosis || Chronic Clinical Course || Hypercellular Bone Marrow || Granulocytes Increased in Bone Marrow


Ampulla of Vater Neuroendocrine Tumor G1

Rosette Formation || Organoid Pattern || Trabecular Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present


Abdominal Mass
Unfavorable Clinical Outcome

Abdominal Mass || Unfavorable Clinical Outcome


Duodenal Somatostatin-Producing Neuroendocrine Tumor

Diarrhea
Psammoma Body Formation
Weight Loss

Diarrhea || Psammoma Body Formation || Weight Loss


Gastroesophageal Junction Large Cell Neuroendocrine Carcinoma

Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


Neuron-Specific Enolase Positive Neoplastic Cells Present

Lymphoblasts 25 Percent or Less of Bone Marrow Nucleated Cells


Thyroid Gland Langerhans Cell Histiocytosis

CD68-Positive Neoplastic Cells Present
Sinusoidal Infiltration

CD68-Positive Neoplastic Cells Present || Sinusoidal Infiltration

Metastatic Malignant Neoplasm in the Lymph Nodes


Aggressive Clinical Course
Painless Mass

Aggressive Clinical Course || Painless Mass


Ampulla of Vater Somatostatin-Producing Neuroendocrine Tumor


Stage II Nasopharyngeal Carcinoma AJCC v7

Headache
Nasal Obstruction
Tinnitus
Neck Mass
Rhinorrhea
Weight Loss

Headache || Nasal Obstruction || Tinnitus || Neck Mass || Rhinorrhea || Weight Loss


Poorly Differentiated Lesion || Neuroendocrine Differentiation || Small Cell Component Present || Mixed Malignant Epithelial Cell Population


Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome


Metastatic Malignant Neoplasm in the Lymph Nodes


Metrorrhagia || Postmenopausal Hemorrhage


Headache
Seizure
Well-Circumscribed Lesion

Headache || Seizure || Well-Circumscribed Lesion


Dysphagia
Pain
Weight Loss
Comedo Necrosis
Regurgitation

Dysphagia || Pain || Weight Loss || Comedo Necrosis || Regurgitation


Cytopenia
Pathologic Fracture
Hepatomegaly
Hypersplenism
Portal Hypertension
Malabsorption Syndrome
Splenomegaly
Lytic Bone Lesion
Serum Total Tryptase Levels Increased

Cytopenia || Pathologic Fracture || Hepatomegaly || Hypersplenism || Portal Hypertension || Malabsorption Syndrome || Splenomegaly || Lytic Bone Lesion || Serum Total Tryptase Levels Increased


Locally Advanced Papillary Renal Cell Carcinoma

Calcification
Flank Pain
Hematuria
Hemorrhagic Change
Necrotic Change
Tubular Pattern
Cystic Change

Calcification || Flank Pain || Hematuria || Hemorrhagic Change || Necrotic Change || Tubular Pattern || Cystic Change


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


HMB-45-Positive Neoplastic Cells Present


Cutaneous Histiocytic and Dendritic Cell Neoplasm


Anaplastic Large Cell Lymphoma, ALK-Negative

Lymphadenopathy
Aggressive Clinical Course
Extranodal Disease

Lymphadenopathy || Aggressive Clinical Course || Extranodal Disease


Metastatic Clear Cell Sarcoma of Soft Tissue

Melanosomes Present || Slow Growing Mass


Ann Arbor Stage II Non-Contiguous Adult Burkitt Lymphoma

Lymphadenopathy
Aggressive Clinical Course
Bulky Disease

Lymphadenopathy || Aggressive Clinical Course || Bulky Disease


Pathologic Stage IIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Abdominal Pain
Dysphagia
Intestinal Metaplasia
Weight Loss

Abdominal Pain || Dysphagia || Intestinal Metaplasia || Weight Loss


Headache
Seizure
Motor Manifestations
Sensory Manifestations
Unfavorable Clinical Outcome

Headache || Seizure || Motor Manifestations || Sensory Manifestations || Unfavorable Clinical Outcome


Encapsulated Mass
Myxoid Stroma Formation
Cartilaginous Component Present
Lipomatous Component Present
Osseous Component Present
Slow Growing Painless Mass

Encapsulated Mass || Myxoid Stroma Formation || Cartilaginous Component Present || Lipomatous Component Present || Osseous Component Present || Slow Growing Painless Mass


Stage II Pleural Malignant Mesothelioma AJCC v8

Anorexia
Chest Pain
Dyspnea
Fatigue
Pleural Effusion
Sweating
Chills
Malaise
Weight Loss

Anorexia || Chest Pain || Dyspnea || Fatigue || Pleural Effusion || Sweating || Chills || Malaise || Weight Loss


Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7

Cold Nodule
Solid Growth Pattern
Trabecular Pattern
Follicular Structures Present

Cold Nodule || Solid Growth Pattern || Trabecular Pattern || Follicular Structures Present


Monoclonal Gammopathy
Unfavorable Clinical Outcome

Monoclonal Gammopathy || Unfavorable Clinical Outcome


Hilar Cholangiocarcinoma by AJCC v7 Stage

Abdominal Pain
Cholangitis
Jaundice
Malaise
Weight Loss
Unfavorable Clinical Outcome

Abdominal Pain || Cholangitis || Jaundice || Malaise || Weight Loss || Unfavorable Clinical Outcome


Recurrent Ovarian Endometrioid Adenocarcinoma

Abdominal Mass
Ascites
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Unfavorable Clinical Outcome


Ann Arbor Stage II Adult Immunoblastic Lymphoma

Lymphadenopathy
CD30-Positive Neoplastic Cells Present

Lymphadenopathy || CD30-Positive Neoplastic Cells Present


Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm


Abdominal Pain
Dyspepsia
Gastric Hemorrhage

Abdominal Pain || Dyspepsia || Gastric Hemorrhage


Refractory Diffuse Intrinsic Pontine Glioma


Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

Abdominal Pain
Diabetes Mellitus
Jaundice
Weight Loss

Abdominal Pain || Diabetes Mellitus || Jaundice || Weight Loss


Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body


Testicular Mixed Yolk Sac Tumor and Teratoma

Testicular Mass
Cytoplasmic Hyaline Globules Present
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation
Schiller-Duval Body

Testicular Mass || Cytoplasmic Hyaline Globules Present || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation || Schiller-Duval Body


Stage III Differentiated Thyroid Gland Carcinoma AJCC v8


Constipation || Neuron-Specific Enolase Positive Neoplastic Cells Present


Hematuria || Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


Clinical Stage II Merkel Cell Carcinoma AJCC v8

Diffuse Pattern
Nodular Pattern
Trabecular Pattern

Diffuse Pattern || Nodular Pattern || Trabecular Pattern


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome


Resectable Pleural Malignant Mesothelioma


Eccrine Differentiation
Apocrine Differentiation

Eccrine Differentiation || Apocrine Differentiation


Rosette Formation || Aggressive Clinical Course || Trabecular Pattern || Sheet-Like Growth Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present


Refractory Angioimmunoblastic T-Cell Lymphoma

Skin Rash
Hepatomegaly
Splenomegaly
Lymphadenopathy
Aggressive Clinical Course

Skin Rash || Hepatomegaly || Splenomegaly || Lymphadenopathy || Aggressive Clinical Course


Testicular Yolk Sac Tumor, Polyvesicular Vitelline Pattern

Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body
Painless Testicular Mass

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body || Painless Testicular Mass


Refractory Adult T-Cell Leukemia/Lymphoma


Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma


Stage 0 Hilar Cholangiocarcinoma AJCC v8


Skin Sclerosing/Morphoeic Basal Cell Carcinoma


Epistaxis
Headache
Nasal Mass
Rhinorrhea

Epistaxis || Headache || Nasal Mass || Rhinorrhea


Calcification
Flexner-Wintersteiner Rosette Formation
Homer Wright Rosette Formation
Necrotic Change

Calcification || Flexner-Wintersteiner Rosette Formation || Homer Wright Rosette Formation || Necrotic Change


Thyroid Gland Sclerosing Mucoepidermoid Carcinoma with Eosinophilia

Cold Nodule
Globular Hyaline Body
Indolent Clinical Course
Well-Circumscribed Lesion

Cold Nodule || Globular Hyaline Body || Indolent Clinical Course || Well-Circumscribed Lesion


Malignant Melanotic Peripheral Nerve Sheath Tumor of the Mediastinum

Aggressive Clinical Course
Geographic Necrosis

Aggressive Clinical Course || Geographic Necrosis


Fever
Hemorrhagic Change
Homer Wright Rosette Formation
Necrotic Change

Fever || Hemorrhagic Change || Homer Wright Rosette Formation || Necrotic Change


Primary Cutaneous Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue


Abnormal Vaginal Discharge
Vaginal Hemorrhage

Abnormal Vaginal Discharge || Vaginal Hemorrhage


Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8

Abdominal Pain
Dysphagia
Intestinal Metaplasia
Weight Loss

Abdominal Pain || Dysphagia || Intestinal Metaplasia || Weight Loss


Ann Arbor Stage IV Angioimmunoblastic T-Cell Lymphoma


Bladder Non-Invasive Papillary Urothelial Carcinoma


Headache || Vomiting || Neurological Signs and Symptoms || HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Acute Myeloid Leukemia with MLL Rearrangement


Abdominal Pain
Constipation
Fever
Intestinal Hemorrhage
Weight Loss

Abdominal Pain || Constipation || Fever || Intestinal Hemorrhage || Weight Loss


Beta-Catenin-Activated Inflammatory Hepatocellular Adenoma

Fibrosis
Hemorrhagic Change
Necrotic Change

Fibrosis || Hemorrhagic Change || Necrotic Change


Ann Arbor Stage I Enteropathy-Associated T-Cell Lymphoma

Aggressive Clinical Course
Chronic Inflammatory Infiltrate

Aggressive Clinical Course || Chronic Inflammatory Infiltrate


Stage I Hypopharyngeal Squamous Cell Carcinoma AJCC v7


Stage IIC Cutaneous Melanoma AJCC v6 and v7

HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Advanced Chromophobe Renal Cell Carcinoma


Dysuria
Pelvic Pain
Postcoital Bleeding
Vaginal Hemorrhage

Dysuria || Pelvic Pain || Postcoital Bleeding || Vaginal Hemorrhage


Abdominal Mass
Abdominal Pain
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Abdominal Mass || Abdominal Pain || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Locally Advanced Unresectable Rectal Adenocarcinoma

Intestinal Hemorrhage || Rectal Hemorrhage


Stage I Lung Squamous Cell Carcinoma AJCC v7


Locally Advanced Unclassified Renal Cell Carcinoma

Flank Pain
Hematuria
Mixed Cellular Population
Mixture of Morphologic Patterns

Flank Pain || Hematuria || Mixed Cellular Population || Mixture of Morphologic Patterns


Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Sinonasal Non-Keratinizing Squamous Cell Carcinoma

Epistaxis
Pain
Rhinorrhea
Exophytic Papillary Lesion
Fungating Mass

Epistaxis || Pain || Rhinorrhea || Exophytic Papillary Lesion || Fungating Mass


Hepatomegaly
Splenomegaly
Leukocytosis
Thrombocytosis
Bone Marrow Dysplasia Present
Ring Sideroblasts Present

Hepatomegaly || Splenomegaly || Leukocytosis || Thrombocytosis || Bone Marrow Dysplasia Present || Ring Sideroblasts Present


Postneoadjuvant Therapy Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8


Hemorrhage
Atypia
High Mitotic Activity
Necrotic Change

Hemorrhage || Atypia || High Mitotic Activity || Necrotic Change


Lymphadenopathy
Aggressive Clinical Course
Extranodal Disease

Lymphadenopathy || Aggressive Clinical Course || Extranodal Disease


Central Nervous System Histiocytic and Dendritic Cell Neoplasm


Extrahepatic Bile Duct Adenocarcinoma, Biliary Type

Abdominal Pain
Anorexia
Jaundice
Nausea
Pruritus
Vomiting
Malaise
Weight Loss

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss


Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7

Psammoma Body Formation
Cold Nodule
Indolent Clinical Course
Cystic Change

Psammoma Body Formation || Cold Nodule || Indolent Clinical Course || Cystic Change


Clear Cell Myomelanocytic Tumor of the Falciform Ligament/Ligamentum Teres


Non-Destructive Post-Transplant Lymphoproliferative Disorder


Stage IIIA Ovarian Cancer AJCC v6 and v7

Abdominal Mass
Ascites
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Unfavorable Clinical Outcome


Headache || Vomiting || Neurological Signs and Symptoms || HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Abdominal Mass
Unfavorable Clinical Outcome

Abdominal Mass || Unfavorable Clinical Outcome


Abdominal Pain
Dyspepsia
Gastric Hemorrhage

Abdominal Pain || Dyspepsia || Gastric Hemorrhage


Call Exner Bodies Present
Gyriform Trabecular Pattern
Insular Pattern
Solid Growth Pattern
Macrofollicular Structures Present
Microfollicular Structures Present

Call Exner Bodies Present || Gyriform Trabecular Pattern || Insular Pattern || Solid Growth Pattern || Macrofollicular Structures Present || Microfollicular Structures Present


Transplant-Related Squamous Cell Carcinoma


Ameloblastic Carcinoma-Secondary Type (Dedifferentiated)


Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome


Stage IVC Mucosal Melanoma of the Head and Neck AJCC v7

HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Methotrexate-Associated Peripheral T-Cell Lymphoma


Skin Plaque
Dermatopathic Lymphadenopathy
Chronic Clinical Course
Progressive Disease
Pautrier Microabscess Present
Scaly Skin Eruption
Single Cell Exocytosis
Skin Patch

Skin Plaque || Dermatopathic Lymphadenopathy || Chronic Clinical Course || Progressive Disease || Pautrier Microabscess Present || Scaly Skin Eruption || Single Cell Exocytosis || Skin Patch


Refractory Desmoplastic Small Round Cell Tumor

Abdominal Mass
Ascites
Pain
High Mitotic Activity
Tumor Cell Necrosis

Abdominal Mass || Ascites || Pain || High Mitotic Activity || Tumor Cell Necrosis


Malignant Mediastinal Germ Cell Tumor Stage Grouping of the Pediatric Study Group

Chest Pain
Cough
Hoarseness
Superior Vena Cava Syndrome
Respiratory Distress

Chest Pain || Cough || Hoarseness || Superior Vena Cava Syndrome || Respiratory Distress


Favorable Clinical Outcome
Well-Circumscribed Lesion

Favorable Clinical Outcome || Well-Circumscribed Lesion


Locally Advanced Intrahepatic Cholangiocarcinoma

Abdominal Pain
Malaise
Weight Loss
Thorotrast Exposure
Unfavorable Clinical Outcome

Abdominal Pain || Malaise || Weight Loss || Thorotrast Exposure || Unfavorable Clinical Outcome


Gastrointestinal Stromal Tumor by AJCC v8 Stage


Aggressive Clinical Course
Unfavorable Clinical Outcome
Claudin-Low

Aggressive Clinical Course || Unfavorable Clinical Outcome || Claudin-Low


Hyperdiploid B Acute Lymphoblastic Leukemia

Hepatomegaly || Splenomegaly || Bone Pain || Thrombocytopenia || Lymphadenopathy || Favorable Clinical Outcome || Extensive Bone Marrow and Blood Involvement || Granulocytopenia


Antoni B Pattern
Encapsulated Mass
Verocay Bodies Present

Antoni B Pattern || Encapsulated Mass || Verocay Bodies Present


Follicular Variant Thyroid Gland Papillary Carcinoma


Extrahepatic Bile Duct Squamous Cell Carcinoma

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss


Prostate Adenocarcinoma with Paneth Cell-Like Neuroendocrine Differentiation

Serum Prostate Specific Antigen Increased


Distal Bile Duct Cancer by AJCC v7 Stage

Abdominal Pain
Anorexia
Jaundice
Nausea
Pruritus
Vomiting
Malaise
Weight Loss


Abdominal Pain
Chest Pain
Fever
Headache
Hypertension
Palpitation
Tremor
Multifocal Lesion
Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Abdominal Pain || Chest Pain || Fever || Headache || Hypertension || Palpitation || Tremor || Multifocal Lesion || Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Abnormal Vaginal Discharge
Vaginal Hemorrhage

Abnormal Vaginal Discharge || Vaginal Hemorrhage


Hemorrhage
Mucoid Stroma Formation
Cystic Change

Hemorrhage || Mucoid Stroma Formation || Cystic Change


Lung Large Cell Carcinoma, Clear Cell Variant


Vulvar Intraepithelial Neoplasia, Differentiated Type

Pruritus || Macular Lesion || Papular Lesion


Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Parathyroid Gland Mixed Cell Type Adenoma

Acinar Pattern
Encapsulated Mass
Solid Growth Pattern
Trabecular Pattern
Follicular Structures Present

Acinar Pattern || Encapsulated Mass || Solid Growth Pattern || Trabecular Pattern || Follicular Structures Present


Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7


Ovarian Yolk Sac Tumor, Polyvesicular Vitelline Pattern

Abdominal Mass
Abdominal Pain
Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body

Abdominal Mass || Abdominal Pain || Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body


Adult Intracranial Solitary Fibrous Tumor/Hemangiopericytoma, Grade 3


B Lymphoblastic Leukemia/Lymphoma with Hypodiploidy

Hepatomegaly
Lymphadenopathy
Unfavorable Clinical Outcome

Hepatomegaly || Lymphadenopathy || Unfavorable Clinical Outcome


Invasive Lobular Breast Carcinoma, Solid Variant

Breast Lump
Pain
Single-File Linear Pattern

Breast Lump || Pain || Single-File Linear Pattern


Lymphadenopathy
Aggressive Clinical Course

Lymphadenopathy || Aggressive Clinical Course


Thrombocytopenia
Ineffective Hematopoiesis
Unfavorable Clinical Outcome
Granulocytopenia

Thrombocytopenia || Ineffective Hematopoiesis || Unfavorable Clinical Outcome || Granulocytopenia


Dermal Involvement || HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Epistaxis
Headache
Nasal Mass
Rhinorrhea

Epistaxis || Headache || Nasal Mass || Rhinorrhea


Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1

Auer Rods Present || Favorable Clinical Outcome || Hypercellular Bone Marrow || Myeloblasts 20 Percent or More of Bone Marrow Nucleated Cells


Testicular Mixed Embryonal Carcinoma and Seminoma


Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present

FIP1L1-PDGFRalpha Fusion Protein Expression


Chest Pain
Cough
Fever
Pneumothorax
Respiratory Distress
Aggressive Clinical Course

Chest Pain || Cough || Fever || Pneumothorax || Respiratory Distress || Aggressive Clinical Course

FIP1L1-PDGFRalpha Fusion Protein Expression


Progressive Disease
Progressive Disease
Pautrier Microabscess Present
Single Cell Exocytosis

Progressive Disease || Pautrier Microabscess Present || Single Cell Exocytosis


Capillary Sized Vascular Channel Formation || Cavernous Vascular Space Formation || Venous Type Vascular Channel Formation


Well-Circumscribed Lesion || Painless Mass


Lymphadenopathy
Aggressive Clinical Course
Bulky Disease

Lymphadenopathy || Aggressive Clinical Course || Bulky Disease


Fallopian Tube Gestational Choriocarcinoma


Differentiated (Simplex) Penile Intraepithelial Neoplasia


Abdominal Mass
Unfavorable Clinical Outcome

Abdominal Mass || Unfavorable Clinical Outcome


Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Mild Cytologic Atypia
Favorable Clinical Outcome
Poor Collagen Rosette Formation

Mild Cytologic Atypia || Favorable Clinical Outcome || Poor Collagen Rosette Formation


Infiltrating Bladder Urothelial Carcinoma with Glandular Differentiation

Dysuria || Hematuria || Urinary Frequency


Diarrhea
Psammoma Body Formation
Weight Loss

Diarrhea || Psammoma Body Formation || Weight Loss


Acute Myeloid Leukemia with t(5;17)(q35;q21)


Sinonasal Spindle Cell Squamous Cell Carcinoma


Ann Arbor Stage II Adult Lymphoblastic Lymphoma

Hepatomegaly || Skin Nodule || Lymphadenopathy || Aggressive Clinical Course || Lymphoblasts 25 Percent or Less of Bone Marrow Nucleated Cells


Intestinal Hemorrhage || Rectal Hemorrhage


Sex Hormone-Producing Adrenal Cortex Adenoma


Abdominal Mass
Anorexia
Diaphragmatic Hernia
Jaundice
Meckel Diverticulum
Thrombocytosis
Weight Loss

Abdominal Mass || Anorexia || Diaphragmatic Hernia || Jaundice || Meckel Diverticulum || Thrombocytosis || Weight Loss


Stage I Adrenal Cortex Carcinoma AJCC v7

Fever
Flank Pain
Abnormal Virilization
Tumor Vascular Invasion
Capsular Invasion

Fever || Flank Pain || Abnormal Virilization || Tumor Vascular Invasion || Capsular Invasion


Anorexia
Chest Pain
Dyspnea
Fatigue
Pleural Effusion
Sweating
Chills
Malaise
Weight Loss
Storiform Growth Pattern

Anorexia || Chest Pain || Dyspnea || Fatigue || Pleural Effusion || Sweating || Chills || Malaise || Weight Loss || Storiform Growth Pattern


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Metastatic Poorly Differentiated Thyroid Gland Carcinoma

Cold Nodule
Insular Pattern
Solid Growth Pattern
Trabecular Pattern

Cold Nodule || Insular Pattern || Solid Growth Pattern || Trabecular Pattern


Minor Salivary Gland Squamous Cell Carcinoma


Gastrointestinal Hemorrhage
Indolent Clinical Course
Intestinal Ulcerated Mass

Gastrointestinal Hemorrhage || Indolent Clinical Course || Intestinal Ulcerated Mass


Skin Nodule
Erythema
Skin Plaque
Peau Chagrine Lesion
Complete Regression

Skin Nodule || Erythema || Skin Plaque || Peau Chagrine Lesion || Complete Regression


Breast Mucosa-Associated Lymphoid Tissue Lymphoma


Headache
Papilledema
Seizure
Sensory Manifestations
Unfavorable Clinical Outcome

Headache || Papilledema || Seizure || Sensory Manifestations || Unfavorable Clinical Outcome


Extrahepatic Bile Duct Small Cell Carcinoma

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss || Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


HMB-45-Positive Neoplastic Cells Present


Colorectal High Grade B-Cell Lymphoma, Not Otherwise Specified

Aggressive Clinical Course
Morphologic Overlap

Aggressive Clinical Course || Morphologic Overlap


Hepatomegaly || Neoplastic Plasma Cells Present in Bone Marrow


Mucosal Melanoma of the Digestive System


Hodgkin-Like Adult T-Cell Leukemia/Lymphoma


Hereditary Papillary Renal Cell Carcinoma

Calcification
Flank Pain
Hematuria
Hemorrhagic Change
Necrotic Change
Tubular Pattern
Bilateral Disease
Cystic Change
Multiple Tumor Masses

Calcification || Flank Pain || Hematuria || Hemorrhagic Change || Necrotic Change || Tubular Pattern || Bilateral Disease || Cystic Change || Multiple Tumor Masses


Headache
Nasal Obstruction
Tinnitus
Neck Mass
Rhinorrhea
Weight Loss

Headache || Nasal Obstruction || Tinnitus || Neck Mass || Rhinorrhea || Weight Loss


Chest Pain
Cough
Fatigue
Fever
Superior Vena Cava Syndrome
Weight Loss
Aggressive Clinical Course

Chest Pain || Cough || Fatigue || Fever || Superior Vena Cava Syndrome || Weight Loss || Aggressive Clinical Course


Headache
Seizure
Motor Manifestations
Sensory Manifestations
Unfavorable Clinical Outcome

Headache || Seizure || Motor Manifestations || Sensory Manifestations || Unfavorable Clinical Outcome


Dural Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue


Advanced Ovarian Endometrioid Adenocarcinoma

Abdominal Mass
Ascites
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Unfavorable Clinical Outcome


Serum Prostate Specific Antigen Increased


Lymphadenopathy
CD30-Positive Neoplastic Cells Present

Lymphadenopathy || CD30-Positive Neoplastic Cells Present


Breast Carcinoma with Melanotic Features

Calcification
Breast Lump
Pain
Solid Growth Pattern
Syncytial Pattern
Trabecular Pattern
Cord-Like Pattern

Calcification || Breast Lump || Pain || Solid Growth Pattern || Syncytial Pattern || Trabecular Pattern || Cord-Like Pattern


B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

Hepatomegaly || Splenomegaly || Bone Pain || Thrombocytopenia || Lymphadenopathy || Favorable Clinical Outcome || Extensive Bone Marrow and Blood Involvement || Granulocytopenia


Unresectable Hypopharyngeal Squamous Cell Carcinoma


Adult Undifferentiated High Grade Pleomorphic Sarcoma of Bone


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Antoni B Pattern
Encapsulated Mass
Verocay Bodies Present

Antoni B Pattern || Encapsulated Mass || Verocay Bodies Present


Stage I Thyroid Gland Papillary Carcinoma AJCC v7

Psammoma Body Formation
Cold Nodule
Indolent Clinical Course
Cystic Change

Psammoma Body Formation || Cold Nodule || Indolent Clinical Course || Cystic Change


Dysuria
Pelvic Pain
Postcoital Bleeding
Dyspareunia
Vaginal Hemorrhage

Dysuria || Pelvic Pain || Postcoital Bleeding || Dyspareunia || Vaginal Hemorrhage


Stage IV Thyroid Gland Papillary Carcinoma AJCC v7


Abdominal Mass
Abdominal Pain
Hematuria
Hypertension

Abdominal Mass || Abdominal Pain || Hematuria || Hypertension


T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant

Effusion
Hepatomegaly
Thrombocytopenia
Lymphadenopathy
Aggressive Clinical Course
Cutaneous Involvement
Cytoplasmic Protrusions Present
Unfavorable Clinical Outcome

Effusion || Hepatomegaly || Thrombocytopenia || Lymphadenopathy || Aggressive Clinical Course || Cutaneous Involvement || Cytoplasmic Protrusions Present || Unfavorable Clinical Outcome


Ann Arbor Stage II Contiguous Mantle Cell Lymphoma

Lymphadenopathy
Aggressive Clinical Course

Lymphadenopathy || Aggressive Clinical Course


Infiltrating Renal Pelvis Urothelial Carcinoma, Sarcomatoid Variant

Flank Pain
Hematuria
Aggressive Clinical Course

Flank Pain || Hematuria || Aggressive Clinical Course


Recurrent Submandibular Gland Mucoepidermoid Carcinoma


Appendicitis || Rosette Formation || Organoid Pattern || Trabecular Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present


Anaplastic (Malignant) Intracranial Meningioma

Headache
Seizure
High Mitotic Activity
Unfavorable Clinical Outcome
Well-Circumscribed Lesion

Headache || Seizure || High Mitotic Activity || Unfavorable Clinical Outcome || Well-Circumscribed Lesion


Recurrent Triple-Negative Breast Carcinoma

Aggressive Clinical Course
Unfavorable Clinical Outcome
Claudin-Low

Aggressive Clinical Course || Unfavorable Clinical Outcome || Claudin-Low


Stage IVB Thyroid Gland Anaplastic Carcinoma AJCC v8

Dysphagia
Dyspnea
Hoarseness
Vocal Cord Paralysis
Aggressive Clinical Course
Coagulative Necrosis

Dysphagia || Dyspnea || Hoarseness || Vocal Cord Paralysis || Aggressive Clinical Course || Coagulative Necrosis


Metastatic Thyroid Gland Medullary Carcinoma

Metastatic Malignant Neoplasm in the Lymph Nodes || Cold Nodule || Organoid Pattern || Trabecular Pattern


Abdominal Pain
Constipation
Fever
Intestinal Hemorrhage
Weight Loss

Abdominal Pain || Constipation || Fever || Intestinal Hemorrhage || Weight Loss


Intestinal Hemorrhage || Rectal Hemorrhage


Adult Acute Myeloid Leukemia with Recurrent Genetic Abnormalities


Abdominal Pain
Malaise
Weight Loss
Unfavorable Clinical Outcome

Abdominal Pain || Malaise || Weight Loss || Unfavorable Clinical Outcome


HMB-45-Positive Neoplastic Cells Present


Central Nervous System Epithelioid Hemangioendothelioma


Diffuse Pattern
Nodular Pattern
Trabecular Pattern

Diffuse Pattern || Nodular Pattern || Trabecular Pattern


Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Stage II Adrenal Cortex Carcinoma AJCC v7

Fever
Flank Pain
Abnormal Virilization
Tumor Vascular Invasion
Capsular Invasion

Fever || Flank Pain || Abnormal Virilization || Tumor Vascular Invasion || Capsular Invasion


Antoni B Pattern
Encapsulated Mass
Verocay Bodies Present

Antoni B Pattern || Encapsulated Mass || Verocay Bodies Present


Thrombocytopenia
Ineffective Hematopoiesis
Unfavorable Clinical Outcome
Granulocytopenia

Thrombocytopenia || Ineffective Hematopoiesis || Unfavorable Clinical Outcome || Granulocytopenia


Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Ann Arbor Stage III Noncutaneous Anaplastic Large Cell Lymphoma


Ann Arbor Stage IV Grade 3 Follicular Lymphoma


Recurrent Parotid Gland Adenoid Cystic Carcinoma

Pain
Cribriform Pattern
Solid Growth Pattern
Tubular Pattern
Slow Growing Mass

Pain || Cribriform Pattern || Solid Growth Pattern || Tubular Pattern || Slow Growing Mass


Splenic Manifestation of B-Cell Prolymphocytic Leukemia

Thrombocytopenia
Unfavorable Clinical Outcome

Thrombocytopenia || Unfavorable Clinical Outcome


Stage IV Nasopharyngeal Carcinoma AJCC v8

Headache
Nasal Obstruction
Tinnitus
Neck Mass
Rhinorrhea
Weight Loss

Headache || Nasal Obstruction || Tinnitus || Neck Mass || Rhinorrhea || Weight Loss


Pathologic Stage IV Merkel Cell Carcinoma AJCC v8


Acute Myelomonocytic Leukemia without Abnormal Eosinophils

Fatigue
Fever
Thrombocytopenia
Leukocytosis
Hemophagocytosis
Hypercellular Bone Marrow

Fatigue || Fever || Thrombocytopenia || Leukocytosis || Hemophagocytosis || Hypercellular Bone Marrow


Salivary Gland Poorly Differentiated Squamous Cell Carcinoma


Lymphadenopathy
Aggressive Clinical Course

Lymphadenopathy || Aggressive Clinical Course


Glioblastoma with Primitive Neuronal Component

Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome


Hemosiderin Deposition
Chronic Clinical Course
Globular Hyaline Body
Red Blood Cells Extravasation
Slit-Like Vascular Channel Formation

Hemosiderin Deposition || Chronic Clinical Course || Globular Hyaline Body || Red Blood Cells Extravasation || Slit-Like Vascular Channel Formation

Dilated Thin-Walled Vascular Space Formation


Recurrent Renal Pelvis and Ureter Urothelial Carcinoma


Locally Advanced Nasopharyngeal Squamous Cell Carcinoma


Breast Carcinoma with Chondroid Metaplasia


Unresectable Cervical Adenosquamous Carcinoma

Abnormal Vaginal Discharge
Vaginal Hemorrhage

Abnormal Vaginal Discharge || Vaginal Hemorrhage


Unresectable Adrenal Gland Pheochromocytoma

Abdominal Pain
Chest Pain
Fever
Headache
Hypertension
Palpitation
Tremor
Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Abdominal Pain || Chest Pain || Fever || Headache || Hypertension || Palpitation || Tremor || Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Headache
Papilledema
Seizure
Sensory Manifestations
Unfavorable Clinical Outcome

Headache || Papilledema || Seizure || Sensory Manifestations || Unfavorable Clinical Outcome


Stage IIIB Lung Adenosquamous Carcinoma AJCC v7


FIP1L1-PDGFRalpha Fusion Protein Expression


Abdominal Mass
Abdominal Pain
Hematuria
Hypertension

Abdominal Mass || Abdominal Pain || Hematuria || Hypertension


Lung Squamous Cell Carcinoma, Papillary Variant


Stage III Lung Large Cell Carcinoma AJCC v7


Cough
Dyspnea
Fever
Hemoptysis
Aggressive Clinical Course

Cough || Dyspnea || Fever || Hemoptysis || Aggressive Clinical Course


Headache
Seizure
Motor Manifestations
Sensory Manifestations
Unfavorable Clinical Outcome

Headache || Seizure || Motor Manifestations || Sensory Manifestations || Unfavorable Clinical Outcome


Abdominal Mass
Ascites
Psammoma Body Formation
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Psammoma Body Formation || Unfavorable Clinical Outcome


Epistaxis
Headache
Nasal Mass
Rhinorrhea

Epistaxis || Headache || Nasal Mass || Rhinorrhea


Antoni B Pattern
Encapsulated Mass
Verocay Bodies Present

Antoni B Pattern || Encapsulated Mass || Verocay Bodies Present


Abdominal Mass
Unfavorable Clinical Outcome

Abdominal Mass || Unfavorable Clinical Outcome


Myelodysplastic Syndrome with Ring Sideroblasts and Single Lineage Dysplasia

Anisochromasia
Chronic Clinical Course
Hypercellular Bone Marrow

Anisochromasia || Chronic Clinical Course || Hypercellular Bone Marrow


Non-Metastatic Alveolar Soft Part Sarcoma


Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body


Capillary Sized Vascular Channel Formation || Cavernous Vascular Space Formation || Venous Type Vascular Channel Formation


Aggressive Clinical Course
Hypercellular Bone Marrow

Aggressive Clinical Course || Hypercellular Bone Marrow


Abdominal Mass
Ascites
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Unfavorable Clinical Outcome


Lymphomatoid Papulosis with DUSP22-IRF4 Gene Rearrangement

Skin Nodule
Indolent Clinical Course
Papular Lesion

Skin Nodule || Indolent Clinical Course || Papular Lesion


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Thrombocytopenia
Ineffective Hematopoiesis
Unfavorable Clinical Outcome
Granulocytopenia

Thrombocytopenia || Ineffective Hematopoiesis || Unfavorable Clinical Outcome || Granulocytopenia


Ann Arbor Stage I Adult Lymphoblastic Lymphoma

Hepatomegaly || Skin Nodule || Lymphadenopathy || Aggressive Clinical Course || Lymphoblasts 25 Percent or Less of Bone Marrow Nucleated Cells


Stage IIIA Choroidal and Ciliary Body Melanoma AJCC v8


Mediastinal Mixed Embryonal Carcinoma and Teratoma

Chest Pain
Cough
Fever
Hoarseness
Superior Vena Cava Syndrome
Respiratory Distress
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation
Multilocular Thymic Cyst

Chest Pain || Cough || Fever || Hoarseness || Superior Vena Cava Syndrome || Respiratory Distress || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation || Multilocular Thymic Cyst


Headache
Seizure
Well-Circumscribed Lesion

Headache || Seizure || Well-Circumscribed Lesion


Abdominal Pain
Malaise
Weight Loss
Unfavorable Clinical Outcome

Abdominal Pain || Malaise || Weight Loss || Unfavorable Clinical Outcome


Stage III Differentiated Thyroid Gland Carcinoma AJCC v8


Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFB-MYH11

Auer Rods Present
Favorable Clinical Outcome
Hypercellular Bone Marrow

Auer Rods Present || Favorable Clinical Outcome || Hypercellular Bone Marrow


Abdominal Pain
Constipation
Fever
Intestinal Hemorrhage
Weight Loss

Abdominal Pain || Constipation || Fever || Intestinal Hemorrhage || Weight Loss


Advanced Ovarian Endometrioid Adenocarcinoma


Stage IB Lung Large Cell Carcinoma AJCC v7


Well-Circumscribed Lesion || Painless Mass


Hepatomegaly || Splenomegaly || Bone Pain || Thrombocytopenia || Lymphadenopathy || Extensive Bone Marrow and Blood Involvement || Granulocytopenia

Clonal Immunoglobulin Heavy Chain Gene Rearrangement


EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Aggressive Clinical Course
Monomorphic Cellular Infiltrate
Polymorphic Cellular Infiltrate

Aggressive Clinical Course || Monomorphic Cellular Infiltrate || Polymorphic Cellular Infiltrate


Differentiated (Simplex) Penile Intraepithelial Neoplasia


Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body
Painless Testicular Mass

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body || Painless Testicular Mass


Abnormal Vaginal Discharge
Vaginal Hemorrhage

Abnormal Vaginal Discharge || Vaginal Hemorrhage


Hepatomegaly || Neoplastic Plasma Cells Present in Bone Marrow


Lymphadenopathy
Aggressive Clinical Course
Bulky Disease

Lymphadenopathy || Aggressive Clinical Course || Bulky Disease


Gastric and Omental Gastrointestinal Stromal Tumor by AJCC v8 Stage


Breast Lump
Pain
Aggressive Clinical Course
Lymphoplasmacytic Infiltrate

Breast Lump || Pain || Aggressive Clinical Course || Lymphoplasmacytic Infiltrate


Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome


Abdominal Mass
Ascites
Psammoma Body Formation
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Psammoma Body Formation || Unfavorable Clinical Outcome


Fibrosis
Hemorrhagic Change
Necrotic Change

Fibrosis || Hemorrhagic Change || Necrotic Change


Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Headache || Vomiting || Neurological Signs and Symptoms || HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Retinoblastoma by AJCC v8 Clinical Stage

Calcification
Flexner-Wintersteiner Rosette Formation
Homer Wright Rosette Formation
Necrotic Change

Calcification || Flexner-Wintersteiner Rosette Formation || Homer Wright Rosette Formation || Necrotic Change


Stage IA Distal Bile Duct Cancer AJCC v7

Abdominal Pain
Anorexia
Jaundice
Nausea
Pruritus
Vomiting
Malaise
Weight Loss

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss


Metastatic Thyroid Gland Hurthle Cell Carcinoma

Tumor Vascular Invasion
Cold Nodule
Solid Growth Pattern
Trabecular Pattern
Capsular Invasion
Follicular Structures Present

Tumor Vascular Invasion || Cold Nodule || Solid Growth Pattern || Trabecular Pattern || Capsular Invasion || Follicular Structures Present


Recurrent Intravascular Large B-Cell Lymphoma

Hypertension Pancytopenia Lymphadenopathy Leukopenia

Hypertension || Pancytopenia || Lymphadenopathy || Leukopenia


Metrorrhagia || Postmenopausal Hemorrhage


Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1

Hepatomegaly || Splenomegaly || Bone Pain || Thrombocytopenia || Lymphadenopathy || Coarse Azurophilic Granules Present || Extensive Bone Marrow and Blood Involvement || Unfavorable Clinical Outcome || Granulocytopenia


Stage III T Lymphoblastic Leukemia/Lymphoma

Hepatomegaly
Malignant Pleural Effusion
Lymphadenopathy
High Mitotic Activity
Starry Sky Pattern

Hepatomegaly || Malignant Pleural Effusion || Lymphadenopathy || High Mitotic Activity || Starry Sky Pattern


Gastric Large Cell Neuroendocrine Carcinoma

Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


Lymphadenopathy
Aggressive Clinical Course

Lymphadenopathy || Aggressive Clinical Course

Pituitary Tumor Transforming Gene Overexpression


Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Refractory Pleural Malignant Mesothelioma

Anorexia
Chest Pain
Dyspnea
Fatigue
Pleural Effusion
Sweating
Chills
Malaise
Weight Loss

Anorexia || Chest Pain || Dyspnea || Fatigue || Pleural Effusion || Sweating || Chills || Malaise || Weight Loss


Locally Advanced Adrenal Cortex Carcinoma

Fever
Flank Pain
Abnormal Virilization
Tumor Vascular Invasion
Capsular Invasion

Fever || Flank Pain || Abnormal Virilization || Tumor Vascular Invasion || Capsular Invasion


Lymphoplasmacytic Lymphoma by Ann Arbor Stage


Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component

Infertility
Metrorrhagia
Obesity
Postmenopausal Hemorrhage

Infertility || Metrorrhagia || Obesity || Postmenopausal Hemorrhage


Resectable Pleural Malignant Mesothelioma


Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Intestinal T-Cell Lymphoma, Not Otherwise Specified


Constipation || Neuron-Specific Enolase Positive Neoplastic Cells Present


Hilar Cholangiocarcinoma by AJCC v7 Stage

Abdominal Pain
Cholangitis
Jaundice
Malaise
Weight Loss
Unfavorable Clinical Outcome

Abdominal Pain || Cholangitis || Jaundice || Malaise || Weight Loss || Unfavorable Clinical Outcome


Calcification
Flank Pain
Hematuria
Hemorrhagic Change
Necrotic Change
Tubular Pattern
Cystic Change

Calcification || Flank Pain || Hematuria || Hemorrhagic Change || Necrotic Change || Tubular Pattern || Cystic Change


Pathologic Stage IV Merkel Cell Carcinoma AJCC v8

Diffuse Pattern
Nodular Pattern
Trabecular Pattern

Diffuse Pattern || Nodular Pattern || Trabecular Pattern


Stage II Nasopharyngeal Carcinoma AJCC v7

Headache
Nasal Obstruction
Tinnitus
Neck Mass
Rhinorrhea
Weight Loss

Headache || Nasal Obstruction || Tinnitus || Neck Mass || Rhinorrhea || Weight Loss


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Abdominal Mass || Abdominal Pain || Jaundice


Abdominal Pain
Jaundice
Pruritus
Weight Loss

Abdominal Pain || Jaundice || Pruritus || Weight Loss


Abdominal Pain || Dyspepsia || Gastric Hemorrhage || Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


Adult Acute Myeloid Leukemia with t(8;21); (q22; q22.1); RUNX1-RUNX1T1

Auer Rods Present || Favorable Clinical Outcome || Hypercellular Bone Marrow || Myeloblasts 20 Percent or More of Bone Marrow Nucleated Cells


Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7

Cold Nodule
Solid Growth Pattern
Trabecular Pattern
Follicular Structures Present

Cold Nodule || Solid Growth Pattern || Trabecular Pattern || Follicular Structures Present


Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome


Cutaneous Adult T-Cell Leukemia/Lymphoma


Recurrent Platinum-Resistant Ovarian Carcinoma

Abdominal Mass
Ascites
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Unfavorable Clinical Outcome


Lung Large Cell Neuroendocrine Carcinoma

Cough || Dyspnea || Fever || Hemoptysis || Rosette Formation || Aggressive Clinical Course || Trabecular Pattern || Sheet-Like Growth Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present


Advanced Small Intestinal Small Cell Carcinoma

Abdominal Pain || Fever || Intestinal Hemorrhage || Weight Loss || Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


Refractory Diffuse Intrinsic Pontine Glioma


Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type

Abdominal Pain
Diabetes Mellitus
Jaundice
Weight Loss

Abdominal Pain || Diabetes Mellitus || Jaundice || Weight Loss


Stage IVC Mucosal Melanoma of the Head and Neck AJCC v7


Recurrent High Grade Ovarian Serous Adenocarcinoma

Abdominal Mass
Ascites
Psammoma Body Formation
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Psammoma Body Formation || Unfavorable Clinical Outcome


Pathologic Stage 0 Merkel Cell Carcinoma AJCC v8


Endocrine Mucin-Producing Sweat Gland Carcinoma

Cribriform Pattern
Papillary Pattern
Solid Growth Pattern
Cystic Change

Cribriform Pattern || Papillary Pattern || Solid Growth Pattern || Cystic Change


Stage IV Distal Bile Duct Cancer AJCC v7

Abdominal Pain
Anorexia
Jaundice
Nausea
Pruritus
Vomiting
Malaise
Weight Loss

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss


Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8

Abdominal Pain
Dysphagia
Intestinal Metaplasia
Weight Loss

Abdominal Pain || Dysphagia || Intestinal Metaplasia || Weight Loss


Flank Pain
Hematuria
Aggressive Clinical Course
Reticular Growth Pattern
Microcystic Growth Pattern

Flank Pain || Hematuria || Aggressive Clinical Course || Reticular Growth Pattern || Microcystic Growth Pattern


Refractory Extraskeletal Myxoid Chondrosarcoma

Hemorrhagic Change
Cribriform Pattern
Cystic Change
Cord-Like Pattern
Spindle Cell Pattern

Hemorrhagic Change || Cribriform Pattern || Cystic Change || Cord-Like Pattern || Spindle Cell Pattern


Ann Arbor Stage IV Grade 3 Follicular Lymphoma

Lymphadenopathy
Aggressive Clinical Course

Lymphadenopathy || Aggressive Clinical Course


Stage IVB Thyroid Gland Follicular Carcinoma AJCC v8


Refractory Adult T-Cell Leukemia/Lymphoma


Metastatic Malignant Neoplasm in the Lymph Nodes


Stage II Choroidal and Ciliary Body Melanoma AJCC v8

HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Abdominal Pain
Constipation
Fever
Intestinal Hemorrhage
Weight Loss

Abdominal Pain || Constipation || Fever || Intestinal Hemorrhage || Weight Loss


Aggressive Clinical Course
Hypercellular Bone Marrow

Aggressive Clinical Course || Hypercellular Bone Marrow


Primary Cutaneous Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue


Malignant Adrenal Gland Composite Pheochromocytoma

Abdominal Pain
Chest Pain
Fever
Headache
Hypertension
Palpitation
Tremor
Aggressive Clinical Course
Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Abdominal Pain || Chest Pain || Fever || Headache || Hypertension || Palpitation || Tremor || Aggressive Clinical Course || Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Stage 0 Cutaneous Melanoma AJCC v6 and v7

HMB-45-Positive Neoplastic Cells Present


Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


Recurrent Poorly Differentiated Thyroid Gland Carcinoma

Cold Nodule
Insular Pattern
Solid Growth Pattern
Trabecular Pattern

Cold Nodule || Insular Pattern || Solid Growth Pattern || Trabecular Pattern


Ann Arbor Stage I Enteropathy-Associated T-Cell Lymphoma

Aggressive Clinical Course
Chronic Inflammatory Infiltrate

Aggressive Clinical Course || Chronic Inflammatory Infiltrate


Fever
Hemorrhagic Change
Homer Wright Rosette Formation
Necrotic Change

Fever || Hemorrhagic Change || Homer Wright Rosette Formation || Necrotic Change


Abdominal Pain
Chest Pain
Fever
Headache
Hypertension
Palpitation
Tremor
Multifocal Lesion
Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Abdominal Pain || Chest Pain || Fever || Headache || Hypertension || Palpitation || Tremor || Multifocal Lesion || Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Ampulla of Vater Neuroendocrine Tumor G1

Rosette Formation || Organoid Pattern || Trabecular Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present


Pancreatic Intraductal Tubulopapillary Neoplasm with an Associated Invasive Carcinoma

Abdominal Pain
Diabetes Mellitus
Jaundice
Pruritus
Steatorrhea
Vomiting
Weight Loss
Papillary Pattern

Abdominal Pain || Diabetes Mellitus || Jaundice || Pruritus || Steatorrhea || Vomiting || Weight Loss || Papillary Pattern


Gallbladder Adenocarcinoma with Squamous Metaplasia


Dysuria
Pelvic Pain
Postcoital Bleeding
Dyspareunia
Vaginal Hemorrhage

Dysuria || Pelvic Pain || Postcoital Bleeding || Dyspareunia || Vaginal Hemorrhage


Ann Arbor Stage III Adult Burkitt Lymphoma

Lymphadenopathy
Aggressive Clinical Course
Bulky Disease

Lymphadenopathy || Aggressive Clinical Course || Bulky Disease


Anterior Tongue Mucoepidermoid Carcinoma


High Grade Ovarian Serous Adenocarcinoma

Abdominal Mass
Ascites
Psammoma Body Formation
Unfavorable Clinical Outcome

Abdominal Mass || Ascites || Psammoma Body Formation || Unfavorable Clinical Outcome


Stage I Nasopharyngeal Carcinoma AJCC v6

Headache
Nasal Obstruction
Tinnitus
Neck Mass
Rhinorrhea
Weight Loss

Headache || Nasal Obstruction || Tinnitus || Neck Mass || Rhinorrhea || Weight Loss


Abnormal Vaginal Discharge
Vaginal Hemorrhage

Abnormal Vaginal Discharge || Vaginal Hemorrhage


Extrahepatic Bile Duct Squamous Cell Carcinoma

Abdominal Pain
Anorexia
Jaundice
Nausea
Pruritus
Vomiting
Malaise
Weight Loss

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss


Flank Pain
Hematuria
Aggressive Clinical Course
Reticular Growth Pattern
Microcystic Growth Pattern

Flank Pain || Hematuria || Aggressive Clinical Course || Reticular Growth Pattern || Microcystic Growth Pattern


Hemophagocytosis
Hypercellular Bone Marrow
Unfavorable Clinical Outcome

Hemophagocytosis || Hypercellular Bone Marrow || Unfavorable Clinical Outcome


Favorable Clinical Outcome
Well-Circumscribed Lesion

Favorable Clinical Outcome || Well-Circumscribed Lesion


Stage I Intrahepatic Cholangiocarcinoma AJCC v8

Abdominal Pain
Malaise
Weight Loss
Thorotrast Exposure
Unfavorable Clinical Outcome

Abdominal Pain || Malaise || Weight Loss || Thorotrast Exposure || Unfavorable Clinical Outcome


Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia

Anisochromasia
Chronic Clinical Course
Hypercellular Bone Marrow

Anisochromasia || Chronic Clinical Course || Hypercellular Bone Marrow


Infiltrating Bladder Urothelial Carcinoma, Nested Variant

Dysuria
Hematuria
Urinary Frequency
Aggressive Clinical Course

Dysuria || Hematuria || Urinary Frequency || Aggressive Clinical Course


Abdominal Mass
Unfavorable Clinical Outcome

Abdominal Mass || Unfavorable Clinical Outcome


Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia

Hypergammaglobulinemia
Indolent Clinical Course
Granulocytopenia

Hypergammaglobulinemia || Indolent Clinical Course || Granulocytopenia


Acute Myeloid Leukemia with t(6;9) (p23;q34.1); DEK-NUP214

Basophilia
Bone Marrow Dysplasia Present
Hypercellular Bone Marrow
Unfavorable Clinical Outcome

Basophilia || Bone Marrow Dysplasia Present || Hypercellular Bone Marrow || Unfavorable Clinical Outcome


Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder

Acute Inflammatory Infiltrate
Chronic Inflammatory Infiltrate

Acute Inflammatory Infiltrate || Chronic Inflammatory Infiltrate

Extensive Bone Marrow and Blood Involvement


Adult Desmoplastic Small Round Cell Tumor

Abdominal Mass
Ascites
Pain
High Mitotic Activity
Tumor Cell Necrosis

Abdominal Mass || Ascites || Pain || High Mitotic Activity || Tumor Cell Necrosis


Mucosal Melanoma of the Digestive System

HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Headache
Seizure
Motor Manifestations
Sensory Manifestations
Unfavorable Clinical Outcome

Headache || Seizure || Motor Manifestations || Sensory Manifestations || Unfavorable Clinical Outcome


Ovarian Yolk Sac Tumor, Polyvesicular Vitelline Pattern

Abdominal Mass
Abdominal Pain
Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body

Abdominal Mass || Abdominal Pain || Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body


Distal Bile Duct Cancer by AJCC v7 Stage


Abdominal Mass
Abdominal Pain
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Abdominal Mass || Abdominal Pain || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Stage IV Ovarian Teratoma AJCC v6 and v7

Abdominal Mass
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Abdominal Mass || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Clinical Stage IA Cutaneous Melanoma AJCC v8


Abdominal Pain
Constipation
Fever
Intestinal Hemorrhage
Weight Loss

Abdominal Pain || Constipation || Fever || Intestinal Hemorrhage || Weight Loss


Cold Nodule
Globular Hyaline Body
Indolent Clinical Course
Well-Circumscribed Lesion

Cold Nodule || Globular Hyaline Body || Indolent Clinical Course || Well-Circumscribed Lesion


Extrahepatic Bile Duct Adenocarcinoma, Biliary Type

Abdominal Pain
Anorexia
Jaundice
Nausea
Pruritus
Vomiting
Malaise
Weight Loss

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss


Advanced Unclassified Renal Cell Carcinoma

Flank Pain
Hematuria
Mixed Cellular Population
Mixture of Morphologic Patterns

Flank Pain || Hematuria || Mixed Cellular Population || Mixture of Morphologic Patterns


Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma


Calcification
Breast Lump
Pain
Lymphoplasmacytic Infiltrate
Well-Circumscribed Lesion

Calcification || Breast Lump || Pain || Lymphoplasmacytic Infiltrate || Well-Circumscribed Lesion


Hemosiderin Deposition
Chronic Clinical Course
Globular Hyaline Body
Red Blood Cells Extravasation
Slit-Like Vascular Channel Formation

Hemosiderin Deposition || Chronic Clinical Course || Globular Hyaline Body || Red Blood Cells Extravasation || Slit-Like Vascular Channel Formation


Pain || Swelling || Hemosiderin Deposition || Joint Effusion || Dilated Thin-Walled Vascular Space Formation || Capillary Sized Vascular Channel Formation


Pain
Skin Nodule
Subcutaneous Nodule
Multifocal Lesion

Pain || Skin Nodule || Subcutaneous Nodule || Multifocal Lesion


Unfavorable Clinical Outcome
Well-Circumscribed Lesion

Unfavorable Clinical Outcome || Well-Circumscribed Lesion


Malignant Melanotic Peripheral Nerve Sheath Tumor of the Mediastinum

Aggressive Clinical Course
Geographic Necrosis

Aggressive Clinical Course || Geographic Necrosis


Ampulla of Vater Signet Ring Cell Carcinoma


Advanced Cutaneous Melanoma of the Extremity


Lymphadenopathy
Aggressive Clinical Course
Bulky Disease

Lymphadenopathy || Aggressive Clinical Course || Bulky Disease


Sinonasal Spindle Cell Squamous Cell Carcinoma


Poorly Differentiated Lesion || Neuroendocrine Differentiation || Small Cell Component Present || Mixed Malignant Epithelial Cell Population


Headache
Seizure
Well-Circumscribed Lesion

Headache || Seizure || Well-Circumscribed Lesion


Colorectal Microvesicular Hyperplastic Polyp


Localized Disease || Progressive Transformation of Germinal Centers


Antoni B Pattern
Encapsulated Mass
Verocay Bodies Present

Antoni B Pattern || Encapsulated Mass || Verocay Bodies Present


Ovarian Sertoli-Leydig Cell Tumor with Heterologous Elements

Amenorrhea
Hirsutism
Hoarseness
Menorrhagia
Metrorrhagia
Mesenchymal Component Present

Amenorrhea || Hirsutism || Hoarseness || Menorrhagia || Metrorrhagia || Mesenchymal Component Present


Non-Destructive Post-Transplant Lymphoproliferative Disorder


Diarrhea
Steatorrhea
Psammoma Body Formation
Weight Loss

Diarrhea || Steatorrhea || Psammoma Body Formation || Weight Loss


Stage IVB Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7


Adnexal Mass
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Adnexal Mass || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Refractory Monomorphic Epitheliotropic Intestinal T-cell Lymphoma


Hemosiderin Deposition
Globular Hyaline Body
Red Blood Cells Extravasation
Slit-Like Vascular Channel Formation

Hemosiderin Deposition || Globular Hyaline Body || Red Blood Cells Extravasation || Slit-Like Vascular Channel Formation


Hepatomegaly || Neoplastic Plasma Cells Present in Bone Marrow


Extrahepatic Bile Duct Small Cell Carcinoma

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss || Aggressive Clinical Course || Neuron-Specific Enolase Positive Neoplastic Cells Present


Stage I Differentiated Thyroid Gland Carcinoma 55 Years and Older AJCC v8


Abdominal Pain
Constipation
Fever
Intestinal Hemorrhage
Weight Loss

Abdominal Pain || Constipation || Fever || Intestinal Hemorrhage || Weight Loss


Stage IIIB Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8


Abdominal Pain
Back Pain
Constipation
Urinary Frequency

Abdominal Pain || Back Pain || Constipation || Urinary Frequency


Monoclonal Immunoglobulin Deposition Disease

Neoplastic Plasma Cells Present in Bone Marrow

Progressive Transformation of Germinal Centers


Advanced Clear Cell Sarcoma of Soft Tissue

Melanosomes Present || Slow Growing Mass


Acute Myeloid Leukemia Arising from Previous Myeloproliferative Neoplasm


Abdominal Pain
Malaise
Weight Loss
Thorotrast Exposure
Unfavorable Clinical Outcome

Abdominal Pain || Malaise || Weight Loss || Thorotrast Exposure || Unfavorable Clinical Outcome


Bladder Mucosa-Associated Lymphoid Tissue Lymphoma


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Lymphadenopathy
Aggressive Clinical Course

Lymphadenopathy || Aggressive Clinical Course


Transverse Colon Neuroendocrine Tumor G1

Rosette Formation || Organoid Pattern || Trabecular Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present


Invasive Lobular Breast Carcinoma, Solid Variant

Breast Lump
Pain
Single-File Linear Pattern

Breast Lump || Pain || Single-File Linear Pattern


Ann Arbor Stage IV Small Lymphocytic Lymphoma


Hepatoblastoma with Pure Fetal Epithelial Differentiation

Abdominal Mass
Anorexia
Diaphragmatic Hernia
Jaundice
Meckel Diverticulum
Thrombocytosis
Weight Loss

Abdominal Mass || Anorexia || Diaphragmatic Hernia || Jaundice || Meckel Diverticulum || Thrombocytosis || Weight Loss


Acute Monoblastic and Monocytic Leukemia

Hypercellular Bone Marrow
Unfavorable Clinical Outcome

Hypercellular Bone Marrow || Unfavorable Clinical Outcome


Atypical Melanocytic Nevus, Genital Type


Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified


Small Intestinal Gangliocytic Paraganglioma

Gastrointestinal Hemorrhage
Indolent Clinical Course
Intestinal Ulcerated Mass

Gastrointestinal Hemorrhage || Indolent Clinical Course || Intestinal Ulcerated Mass


Childhood Thyroid Gland Papillary Carcinoma

Psammoma Body Formation
Cold Nodule
Indolent Clinical Course
Cystic Change

Psammoma Body Formation || Cold Nodule || Indolent Clinical Course || Cystic Change


Refractory Intravascular Large B-Cell Lymphoma

Hypertension Pancytopenia Lymphadenopathy Leukopenia

Hypertension || Pancytopenia || Lymphadenopathy || Leukopenia


Aggressive Clinical Course
Painless Mass

Aggressive Clinical Course || Painless Mass


Stage IIIB Lung Small Cell Carcinoma with Pleural Effusion AJCC v7

Hemoptysis || Hoarseness || Rosette Formation || Aggressive Clinical Course || Trabecular Pattern || Sheet-Like Growth Pattern || Neuron-Specific Enolase Positive Neoplastic Cells Present || Solitary Pulmonary Nodule


Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Abdominal Mass
Abdominal Pain
Nausea
Vomiting
Weight Loss

Abdominal Mass || Abdominal Pain || Nausea || Vomiting || Weight Loss


Bladder Adenocarcinoma, Not Otherwise Specified


Advanced Chromophobe Renal Cell Carcinoma


Ann Arbor Stage III Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue


Headache
Seizure
Well-Circumscribed Lesion

Headache || Seizure || Well-Circumscribed Lesion


Gastrointestinal Stromal Tumor by AJCC v8 Stage


Stage III Renal Pelvis and Ureter Cancer AJCC v7


Childhood Central Nervous System Neuroblastoma


Poorly Differentiated Thyroid Gland Carcinoma

Cold Nodule
Insular Pattern
Solid Growth Pattern
Trabecular Pattern

Cold Nodule || Insular Pattern || Solid Growth Pattern || Trabecular Pattern


Chest Pain
Cough
Fatigue
Fever
Superior Vena Cava Syndrome
Weight Loss
Aggressive Clinical Course

Chest Pain || Cough || Fatigue || Fever || Superior Vena Cava Syndrome || Weight Loss || Aggressive Clinical Course


Headache
Seizure
Unfavorable Clinical Outcome

Headache || Seizure || Unfavorable Clinical Outcome


Testicular Mixed Yolk Sac Tumor and Teratoma

Testicular Mass
Cytoplasmic Hyaline Globules Present
Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation
Schiller-Duval Body

Testicular Mass || Cytoplasmic Hyaline Globules Present || Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation || Schiller-Duval Body


Stage III Distal Bile Duct Cancer AJCC v7

Abdominal Pain
Anorexia
Jaundice
Nausea
Pruritus
Vomiting
Malaise
Weight Loss

Abdominal Pain || Anorexia || Jaundice || Nausea || Pruritus || Vomiting || Malaise || Weight Loss


Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7

Headache
Nasal Obstruction
Tinnitus
Neck Mass
Rhinorrhea
Weight Loss

Headache || Nasal Obstruction || Tinnitus || Neck Mass || Rhinorrhea || Weight Loss


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Hereditary Papillary Renal Cell Carcinoma

Calcification
Flank Pain
Hematuria
Hemorrhagic Change
Necrotic Change
Tubular Pattern
Bilateral Disease
Cystic Change
Multiple Tumor Masses

Calcification || Flank Pain || Hematuria || Hemorrhagic Change || Necrotic Change || Tubular Pattern || Bilateral Disease || Cystic Change || Multiple Tumor Masses


Epistaxis
Headache
Nasal Mass
Rhinorrhea

Epistaxis || Headache || Nasal Mass || Rhinorrhea


Stage II Pleural Malignant Mesothelioma AJCC v8

Anorexia
Chest Pain
Dyspnea
Fatigue
Pleural Effusion
Sweating
Chills
Malaise
Weight Loss

Anorexia || Chest Pain || Dyspnea || Fatigue || Pleural Effusion || Sweating || Chills || Malaise || Weight Loss


Locally Advanced Nasopharyngeal Squamous Cell Carcinoma


Stage III Testicular Yolk Sac Tumor AJCC v6 and v7

Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body
Painless Testicular Mass

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body || Painless Testicular Mass


Epistaxis || Pain || Nasal Mass || Rhinorrhea


Primary Peritoneal Serous Adenocarcinoma


Malignant Melanoma in Precancerous Melanosis


Ann Arbor Stage IV B Lymphoblastic Lymphoma

Hepatomegaly || Skin Nodule || Lymphadenopathy || Aggressive Clinical Course || Lymphoblasts 25 Percent or Less of Bone Marrow Nucleated Cells


Antoni B Pattern
Encapsulated Mass
Verocay Bodies Present

Antoni B Pattern || Encapsulated Mass || Verocay Bodies Present


Refractory Acute Leukemia of Ambiguous Lineage

Thrombocytopenia
Ineffective Hematopoiesis
Unfavorable Clinical Outcome
Granulocytopenia

Thrombocytopenia || Ineffective Hematopoiesis || Unfavorable Clinical Outcome || Granulocytopenia


Skin Plaque
Dermatopathic Lymphadenopathy
Chronic Clinical Course
Progressive Disease
Pautrier Microabscess Present
Scaly Skin Eruption
Single Cell Exocytosis
Skin Patch

Skin Plaque || Dermatopathic Lymphadenopathy || Chronic Clinical Course || Progressive Disease || Pautrier Microabscess Present || Scaly Skin Eruption || Single Cell Exocytosis || Skin Patch


Cutaneous Histiocytic and Dendritic Cell Neoplasm


Diffuse Pattern
Nodular Pattern
Trabecular Pattern

Diffuse Pattern || Nodular Pattern || Trabecular Pattern


Childhood Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue


Hematuria
Hypertension
Trabecular Pattern
Nesting (Zellballen) Growth Pattern

Hematuria || Hypertension || Trabecular Pattern || Nesting (Zellballen) Growth Pattern


Abdominal Pain
Constipation
Fever
Intestinal Hemorrhage
Weight Loss

Abdominal Pain || Constipation || Fever || Intestinal Hemorrhage || Weight Loss


Dysuria
Pelvic Pain
Postcoital Bleeding
Vaginal Hemorrhage

Dysuria || Pelvic Pain || Postcoital Bleeding || Vaginal Hemorrhage


Calcification || Cough || Hemoptysis || Rosette Formation || Atypia || Organoid Pattern || Trabecular Pattern || Nuclear Pleomorphism || Neuron-Specific Enolase Positive Neoplastic Cells Present


Ann Arbor Stage IV Angioimmunoblastic T-Cell Lymphoma

Skin Rash
Hepatomegaly
Splenomegaly
Lymphadenopathy
Aggressive Clinical Course

Skin Rash || Hepatomegaly || Splenomegaly || Lymphadenopathy || Aggressive Clinical Course


Sinonasal Human Papillomavirus-Related Carcinoma with Adenoid Cystic-Like Features

Epistaxis
Pain
Rhinorrhea
Exophytic Papillary Lesion
Fungating Mass

Epistaxis || Pain || Rhinorrhea || Exophytic Papillary Lesion || Fungating Mass


Unresectable Hypopharyngeal Squamous Cell Carcinoma


Epithelial Predominant Kidney Wilms Tumor

Abdominal Mass
Abdominal Pain
Hematuria
Hypertension
Papillary Pattern
Pseudorosette Formation
Tubular Pattern

Abdominal Mass || Abdominal Pain || Hematuria || Hypertension || Papillary Pattern || Pseudorosette Formation || Tubular Pattern


Abdominal Mass
Unfavorable Clinical Outcome

Abdominal Mass || Unfavorable Clinical Outcome


Epistaxis || Headache || Nasal Mass || Rhinorrhea


Fever
Hemorrhagic Change
Homer Wright Rosette Formation
Necrotic Change

Fever || Hemorrhagic Change || Homer Wright Rosette Formation || Necrotic Change


Ann Arbor Stage I Angioimmunoblastic T-Cell Lymphoma


HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Aggressive Clinical Course
Mitotic Activity
Deep Lesion
Lesion with Diameter Greater than 2 cm
Marked Nuclear Atypia Present

Aggressive Clinical Course || Mitotic Activity || Deep Lesion || Lesion with Diameter Greater than 2 cm || Marked Nuclear Atypia Present


Lung Large Cell Carcinoma, Clear Cell Variant


Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative

Hepatomegaly || Splenomegaly || Thrombocytopenia


Childhood Malignant Peripheral Nerve Sheath Tumor

Aggressive Clinical Course
Geographic Necrosis

Aggressive Clinical Course || Geographic Necrosis


Diarrhea
Psammoma Body Formation
Weight Loss

Diarrhea || Psammoma Body Formation || Weight Loss


Aggressive Clinical Course
Unfavorable Clinical Outcome
Claudin-Low

Aggressive Clinical Course || Unfavorable Clinical Outcome || Claudin-Low


Stage II Nasopharyngeal Carcinoma AJCC v8

Headache
Nasal Obstruction
Tinnitus
Neck Mass
Rhinorrhea
Weight Loss

Headache || Nasal Obstruction || Tinnitus || Neck Mass || Rhinorrhea || Weight Loss


Stage IV Nasopharyngeal Carcinoma AJCC v8


Headache
Seizure
Herringbone Growth Pattern
Unfavorable Clinical Outcome

Headache || Seizure || Herringbone Growth Pattern || Unfavorable Clinical Outcome


Abdominal Mass
Anorexia
Diaphragmatic Hernia
Jaundice
Meckel Diverticulum
Thrombocytosis
Weight Loss

Abdominal Mass || Anorexia || Diaphragmatic Hernia || Jaundice || Meckel Diverticulum || Thrombocytosis || Weight Loss


Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7


Splenic Manifestation of B-Cell Prolymphocytic Leukemia

Thrombocytopenia
Unfavorable Clinical Outcome

Thrombocytopenia || Unfavorable Clinical Outcome


Headache
Vomiting
Ataxic Gait
High Mitotic Activity
Geographic Necrosis

Headache || Vomiting || Ataxic Gait || High Mitotic Activity || Geographic Necrosis


Diffuse Pattern
Nodular Pattern
Trabecular Pattern

Diffuse Pattern || Nodular Pattern || Trabecular Pattern


Invasive Lobular Breast Carcinoma, Pleomorphic Variant

Breast Lump
Pain
Single-File Linear Pattern

Breast Lump || Pain || Single-File Linear Pattern


Stage III Thyroid Gland Medullary Carcinoma AJCC v8

Metastatic Malignant Neoplasm in the Lymph Nodes || Cold Nodule || Organoid Pattern || Trabecular Pattern


Burkitt-Like Lymphoma Post-Transplant Lymphoproliferative Disorder

Lymphadenopathy
Aggressive Clinical Course
Bulky Disease
Extranodal Disease

Lymphadenopathy || Aggressive Clinical Course || Bulky Disease || Extranodal Disease


Stage III Testicular Choriocarcinoma AJCC v6 and v7


Unfavorable Clinical Outcome
Well-Circumscribed Lesion

Unfavorable Clinical Outcome || Well-Circumscribed Lesion


Non-Keratinizing Primary Intraosseous Squamous Cell Carcinoma -Solid Type


Testicular Yolk Sac Tumor, Endodermal Sinus/Perivascular Pattern

Alpha Fetoprotein Increased
Cytoplasmic Hyaline Globules Present
Schiller-Duval Body
Painless Testicular Mass

Alpha Fetoprotein Increased || Cytoplasmic Hyaline Globules Present || Schiller-Duval Body || Painless Testicular Mass


Breast Mucosa-Associated Lymphoid Tissue Lymphoma


Aggressive Clinical Course
High Mitotic Activity
Necrotic Change
Loss of INI 1 Protein Expression

Aggressive Clinical Course || High Mitotic Activity || Necrotic Change || Loss of INI 1 Protein Expression


Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm


Small Intestinal High Grade B-Cell Lymphoma, Not Otherwise Specified

Aggressive Clinical Course
Morphologic Overlap

Aggressive Clinical Course || Morphologic Overlap


Solar Radiation-Related Cutaneous Melanoma

HMB-45-Positive Neoplastic Cells Present || S-100-Positive Neoplastic Cells Present


Pleomorphic Variant Mantle Cell Lymphoma

Lymphadenopathy
Aggressive Clinical Course

Lymphadenopathy || Aggressive Clinical Course


Pancreatic Intraductal Papillary-Mucinous Neoplasm with an Associated Invasive Carcinoma

Abdominal Pain
Diabetes Mellitus
Jaundice
Pruritus
Weight Loss

Abdominal Pain || Diabetes Mellitus || Jaundice || Pruritus || Weight Loss


Apocrine Metaplasia
Microcalcification
Microcystic Change

Apocrine Metaplasia || Microcalcification || Microcystic Change


Ectodermal Differentiation
Endodermal Differentiation
Mesodermal Differentiation

Ectodermal Differentiation || Endodermal Differentiation || Mesodermal Differentiation


Salivary Gland Polymorphous Adenocarcinoma

Pain
Cribriform Pattern
Favorable Clinical Outcome
Papillary Pattern
Trabecular Pattern
Lobular Pattern

Pain || Cribriform Pattern || Favorable Clinical Outcome || Papillary Pattern || Trabecular Pattern || Lobular Pattern


Abdominal Pain
Diarrhea
Intestinal Hemorrhage

Abdominal Pain || Diarrhea || Intestinal Hemorrhage


Cutaneous B Lymphoblastic Leukemia/Lymphoma

Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement || Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


BRAF Gene Mutation
TP53 Gene Inactivation
APC Gene Inactivation
KRAS Gene Amplification
MYC Gene Mutation

BRAF Gene Mutation || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


ERBB2 Gene Amplification
TP53 Gene Inactivation
MYC Gene Amplification
FHIT Gene Inactivation

ERBB2 Gene Amplification || TP53 Gene Inactivation || MYC Gene Amplification || FHIT Gene Inactivation


Recurrent Extensive Stage Lung Small Cell Carcinoma

C-KIT Tyrosine Kinase Protein Overexpression || RB1 Gene Inactivation || TP53 Gene Inactivation || FGFR1 Gene Amplification || NMYC Gene Amplification || PTEN Gene Mutation


TP53 Gene Inactivation
TMPRSS2-ERG Fusion Protein Expression
ERG Gene Rearrangement

TP53 Gene Inactivation || TMPRSS2-ERG Fusion Protein Expression || ERG Gene Rearrangement


NRAS Gene Mutation
KRAS Gene Mutation
HRAS Gene Mutation

NRAS Gene Mutation || KRAS Gene Mutation || HRAS Gene Mutation


Serous Endometrial Intraepithelial Carcinoma


BRAF Gene Mutation || High-Frequency Microsatellite Instability || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


Stage IIIA Mycosis Fungoides and Sezary Syndrome AJCC v7

Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


Adult Desmoplastic Small Round Cell Tumor


Nodular Sclerosis Classic Hodgkin Lymphoma, Cellular Phase

Apoptotic Pathway Deregulation || Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement || Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement || Clonal T-Cell Receptor Gene Rearrangement


Lung Large Cell Neuroendocrine Carcinoma

CDKN2A Gene Deletion || C-KIT Tyrosine Kinase Protein Overexpression || RB1 Gene Inactivation || TP53 Gene Inactivation || FGFR1 Gene Amplification


Ann Arbor Stage II Noncutaneous Anaplastic Large Cell Lymphoma

Clonal T-Cell Receptor Beta Chain Gene Rearrangement


SS18-SSX1 Fusion Protein Expression
SS18-SSX2 Fusion Protein Expression
SS18-SSX4 Fusion Protein Expression

SS18-SSX1 Fusion Protein Expression || SS18-SSX2 Fusion Protein Expression || SS18-SSX4 Fusion Protein Expression


Aneuploidy
CCND1 Gene Amplification
CDKN2A Gene Inactivation
EGFR Gene Amplification
FGF4 Gene Amplification
FGF6 Gene Amplification
TP53 Gene Inactivation
MYC Gene Amplification
FHIT Gene Inactivation

Aneuploidy || CCND1 Gene Amplification || CDKN2A Gene Inactivation || EGFR Gene Amplification || FGF4 Gene Amplification || FGF6 Gene Amplification || TP53 Gene Inactivation || MYC Gene Amplification || FHIT Gene Inactivation


SDHB Gene Mutation
SDHC Gene Mutation
SDHD Gene Mutation

SDHB Gene Mutation || SDHC Gene Mutation || SDHD Gene Mutation


ENSAT Stage III Adrenal Cortex Carcinoma


Thyroid Gland Follicular Adenoma with Papillary Hyperplasia


TMPRSS2-ERG Fusion Protein Expression
ERG Gene Rearrangement

TMPRSS2-ERG Fusion Protein Expression || ERG Gene Rearrangement


Ann Arbor Stage IV Adult Lymphoblastic Lymphoma

Clonal T-Cell Receptor Beta Chain Gene Rearrangement


Stage I Colorectal Cancer AJCC v6 and v7


Metastatic Thyroid Gland Anaplastic Carcinoma

NRAS Gene Mutation
TP53 Gene Inactivation
KRAS Gene Mutation
PTEN Gene Inactivation
HRAS Gene Mutation
BRAF NP_004324.2:p.V600E

NRAS Gene Mutation || TP53 Gene Inactivation || KRAS Gene Mutation || PTEN Gene Inactivation || HRAS Gene Mutation || BRAF NP_004324.2:p.V600E


Locally Advanced Unresectable Cervical Adenocarcinoma


Clonal BCL2 Gene Rearrangement
Clonal BCL6 Gene Rearrangement

Clonal BCL2 Gene Rearrangement || Clonal BCL6 Gene Rearrangement


Refractory Pleural Malignant Mesothelioma

CDKN2A Gene Inactivation
GPC3 Gene Inactivation
NF2 Gene Mutation

CDKN2A Gene Inactivation || GPC3 Gene Inactivation || NF2 Gene Mutation


Anterior Tongue Adenoid Cystic Carcinoma


Extrahepatic Bile Duct Mucoepidermoid Carcinoma


Small Intestinal Gastrointestinal Stromal Tumor

PDGFRA Gene Mutation || KIT Gene Mutation


Gastrointestinal Stromal Tumor of the Gastrointestinal Tract


EGFR Gene Amplification
EGFR Protein Overexpression
PDGFRA Gene Mutation
PDGFRalpha Protein Overexpression
PTEN Gene Inactivation

EGFR Gene Amplification || EGFR Protein Overexpression || PDGFRA Gene Mutation || PDGFRalpha Protein Overexpression || PTEN Gene Inactivation


Hobnail Variant Thyroid Gland Papillary Carcinoma

NRAS Gene Mutation
KRAS Gene Mutation
RET/PTC Rearrangement
NTRK1 Gene Rearrangement
HRAS Gene Mutation
BRAF NP_004324.2:p.V600E

NRAS Gene Mutation || KRAS Gene Mutation || RET/PTC Rearrangement || NTRK1 Gene Rearrangement || HRAS Gene Mutation || BRAF NP_004324.2:p.V600E


Recurrent Oral Cavity Mucoepidermoid Carcinoma


Refractory Transformed Chronic Lymphocytic Leukemia


Stage 0 Colorectal Cancer AJCC v6 and v7


Stage IA Gastric Gastrointestinal Stromal Tumor


Stage IV Esophageal Adenocarcinoma AJCC v7

CDKN2A Gene Inactivation
EGFR Gene Amplification
ERBB2 Gene Amplification
TP53 Gene Inactivation
APC Gene Inactivation
FHIT Gene Inactivation
Loss of E-cadherin Expression

CDKN2A Gene Inactivation || EGFR Gene Amplification || ERBB2 Gene Amplification || TP53 Gene Inactivation || APC Gene Inactivation || FHIT Gene Inactivation || Loss of E-cadherin Expression


Stage IIIA Esophageal Adenocarcinoma AJCC v7


Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8

TP53 Gene Inactivation
MDM2 Gene Mutation

TP53 Gene Inactivation || MDM2 Gene Mutation


EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder

Clonal Immunoglobulin Gene Rearrangement || Clonal T-Cell Receptor Gene Rearrangement


High Grade Prostatic Intraepithelial Neoplasia, Foamy Variant


Refractory Extrarenal Rhabdoid Tumor of the Ovary


Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement


Submucosal Invasive Colon Adenocarcinoma

BRAF Gene Mutation
TP53 Gene Inactivation
APC Gene Inactivation
KRAS Gene Amplification
MYC Gene Mutation

BRAF Gene Mutation || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


Stage IIIB Pleural Malignant Mesothelioma AJCC v8


Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Negative

Clonal T-Cell Receptor Beta Chain Gene Rearrangement


CTNNB1 Gene Mutation
APC Gene Inactivation

CTNNB1 Gene Mutation || APC Gene Inactivation


GNAQ Gene Mutation
GNA11 Gene Mutation
BAP1 Gene Mutation
SF3B1 Gene Mutation
CYSLTR2 Gene Mutation
PLCB4 Gene Mutation
EIF1AX Gene Mutation

GNAQ Gene Mutation || GNA11 Gene Mutation || BAP1 Gene Mutation || SF3B1 Gene Mutation || CYSLTR2 Gene Mutation || PLCB4 Gene Mutation || EIF1AX Gene Mutation


Stage IV Nasopharyngeal Carcinoma AJCC v6

CDKN2A Gene Inactivation
RASSF1A Gene Inactivation

CDKN2A Gene Inactivation || RASSF1A Gene Inactivation


TP53 Gene Inactivation
APC Gene Inactivation
FHIT Gene Inactivation
KRAS Gene Amplification
LKB1 Gene Inactivation
EGFR Gene Mutation

TP53 Gene Inactivation || APC Gene Inactivation || FHIT Gene Inactivation || KRAS Gene Amplification || LKB1 Gene Inactivation || EGFR Gene Mutation


Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8


Stage IIIA Lung Large Cell Carcinoma AJCC v7

TP53 Gene Inactivation
KRAS Gene Mutation
EGFR Gene Mutation

TP53 Gene Inactivation || KRAS Gene Mutation || EGFR Gene Mutation


Microsatellite Instability
CDH1 Gene Inactivation
ERBB2 Gene Amplification
TP53 Gene Inactivation
APC Gene Inactivation
c-MET Gene Amplification

Microsatellite Instability || CDH1 Gene Inactivation || ERBB2 Gene Amplification || TP53 Gene Inactivation || APC Gene Inactivation || c-MET Gene Amplification


Stage IIIA Lung Non-Small Cell Cancer AJCC v7

TP53 Gene Inactivation
EGFR Gene Mutation

TP53 Gene Inactivation || EGFR Gene Mutation


BRAF Gene Mutation || High-Frequency Microsatellite Instability || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


Stage I Acral Lentiginous Melanoma AJCC v7


Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC v8

Aneuploidy
CCND1 Gene Amplification
CDKN2A Gene Inactivation
EGFR Gene Amplification
FGF4 Gene Amplification
FGF6 Gene Amplification
TP53 Gene Inactivation
MYC Gene Amplification
FHIT Gene Inactivation

Aneuploidy || CCND1 Gene Amplification || CDKN2A Gene Inactivation || EGFR Gene Amplification || FGF4 Gene Amplification || FGF6 Gene Amplification || TP53 Gene Inactivation || MYC Gene Amplification || FHIT Gene Inactivation


Stage I Bladder Urothelial Carcinoma AJCC v6 and v7

CCND1 Gene Amplification
CCND1 Protein Overexpression
EGFR Gene Amplification
EGFR Protein Overexpression
ERBB2 Gene Amplification
HRAS Gene Amplification
RB1 Gene Inactivation
TP53 Gene Inactivation
ERBB2 Protein Overexpression
MDM2 Gene Amplification

CCND1 Gene Amplification || CCND1 Protein Overexpression || EGFR Gene Amplification || EGFR Protein Overexpression || ERBB2 Gene Amplification || HRAS Gene Amplification || RB1 Gene Inactivation || TP53 Gene Inactivation || ERBB2 Protein Overexpression || MDM2 Gene Amplification


RB1 Gene Inactivation
TP53 Gene Inactivation
APC Gene Inactivation
FHIT Gene Inactivation

RB1 Gene Inactivation || TP53 Gene Inactivation || APC Gene Inactivation || FHIT Gene Inactivation


Stage IVA Cervical Cancer AJCC v6 and v7

ERBB2 Gene Amplification
TP53 Gene Inactivation
MYC Gene Amplification
FHIT Gene Inactivation

ERBB2 Gene Amplification || TP53 Gene Inactivation || MYC Gene Amplification || FHIT Gene Inactivation


Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement

Clonal Immunoglobulin Heavy Chain Gene Rearrangement


Unresectable Cervical Adenosquamous Carcinoma


Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type


Metastatic Endometrial Serous Adenocarcinoma


Recurrent Adult Acute Lymphoblastic Leukemia


PAX3-FOXO1 Fusion Protein Expression
PAX7-FOXO1 Fusion Protein Expression

PAX3-FOXO1 Fusion Protein Expression || PAX7-FOXO1 Fusion Protein Expression


Digestive System Diffuse Large B-Cell Lymphoma

Clonal Immunoglobulin Heavy Chain Gene Rearrangement


Stage IV Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7


Clonal BCL2 Gene Rearrangement
Clonal BCL6 Gene Rearrangement

Clonal BCL2 Gene Rearrangement || Clonal BCL6 Gene Rearrangement


Lymphocyte-Depleted Classic Hodgkin Lymphoma by Ann Arbor Stage

Apoptotic Pathway Deregulation || Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement || Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement || Clonal T-Cell Receptor Gene Rearrangement


Refractory Chronic Myelomonocytic Leukemia


EWSR1-ETV4 Fusion Protein Expression
EWSR1-ERG Fusion Protein Expression
EWSR1-ETV1 Fusion Protein Expression
EWSR1-FEV Fusion Protein Expression
EWSR1-PATZ1 Fusion Protein Expression
FUS-ERG Fusion Protein Expression
EWSR1-FLI1 Fusion Protein Expression

EWSR1-ETV4 Fusion Protein Expression || EWSR1-ERG Fusion Protein Expression || EWSR1-ETV1 Fusion Protein Expression || EWSR1-FEV Fusion Protein Expression || EWSR1-PATZ1 Fusion Protein Expression || FUS-ERG Fusion Protein Expression || EWSR1-FLI1 Fusion Protein Expression


Lung Non-Squamous Non-Small Cell Carcinoma


Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Negative

Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


BRAF Gene Mutation
TP53 Gene Inactivation
APC Gene Inactivation
KRAS Gene Amplification
MYC Gene Mutation

BRAF Gene Mutation || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


Refractory Epithelioid Malignant Peripheral Nerve Sheath Tumor


Locally Advanced Cervical Adenocarcinoma


Locally Advanced Gastroesophageal Junction Adenocarcinoma

TP53 Gene Inactivation
MDM2 Gene Mutation

TP53 Gene Inactivation || MDM2 Gene Mutation


Unresectable Pleural Malignant Mesothelioma

CDKN2A Gene Inactivation
GPC3 Gene Inactivation
NF2 Gene Mutation

CDKN2A Gene Inactivation || GPC3 Gene Inactivation || NF2 Gene Mutation


BRCA2 Gene Mutation
CDKN2A Gene Inactivation
SMAD4/DPC4 Gene Inactivation
ERBB2 Gene Amplification
RB1 Gene Inactivation
TP53 Gene Inactivation
AKT2 Gene Amplification
KRAS Gene Mutation
MAP2K4 Gene Inactivation

BRCA2 Gene Mutation || CDKN2A Gene Inactivation || SMAD4/DPC4 Gene Inactivation || ERBB2 Gene Amplification || RB1 Gene Inactivation || TP53 Gene Inactivation || AKT2 Gene Amplification || KRAS Gene Mutation || MAP2K4 Gene Inactivation


Laryngeal Papillary Squamous Cell Carcinoma


TP53 Gene Inactivation
MYC Gene Amplification

TP53 Gene Inactivation || MYC Gene Amplification


Stage 0 Lip Basal Cell Carcinoma AJCC v6 and v7


B-Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 21

Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement || Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


Childhood Rhabdomyosarcoma with Mixed Embryonal and Alveolar Features


TP53 Gene Inactivation
KRAS Gene Amplification

TP53 Gene Inactivation || KRAS Gene Amplification


C-KIT Tyrosine Kinase Protein Overexpression || MYC Gene Amplification || NMYC Gene Amplification


CCND1 Gene Amplification
Cyclin D1 Messenger RNA Overexpression
CCND1 Protein Overexpression
ERBB2 Gene Amplification
TP53 Gene Inactivation
ERBB2 Protein Overexpression

CCND1 Gene Amplification || Cyclin D1 Messenger RNA Overexpression || CCND1 Protein Overexpression || ERBB2 Gene Amplification || TP53 Gene Inactivation || ERBB2 Protein Overexpression


BRAF Gene Mutation || High-Frequency Microsatellite Instability || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


Metastatic Prostate Neuroendocrine Carcinoma

TMPRSS2-ERG Fusion Protein Expression
ERG Gene Rearrangement

TMPRSS2-ERG Fusion Protein Expression || ERG Gene Rearrangement


Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia

TEL-ABL Fusion Protein Expression
TEL-JAK2 Fusion Protein Expression
BCR-JAK2 Fusion Protein Expression

TEL-ABL Fusion Protein Expression || TEL-JAK2 Fusion Protein Expression || BCR-JAK2 Fusion Protein Expression


Spindle Cell Variant Thyroid Gland Papillary Carcinoma

NRAS Gene Mutation
KRAS Gene Mutation
RET/PTC Rearrangement
NTRK1 Gene Rearrangement
HRAS Gene Mutation
BRAF NP_004324.2:p.V600E

NRAS Gene Mutation || KRAS Gene Mutation || RET/PTC Rearrangement || NTRK1 Gene Rearrangement || HRAS Gene Mutation || BRAF NP_004324.2:p.V600E


Pancreatic Acinar Cell Cystadenocarcinoma


Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8


Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8


Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement


Clinical Stage III Retinoblastoma AJCC v8


EGFR Gene Amplification
EGFR Protein Overexpression
TP53 Gene Inactivation
MDM2 Gene Amplification
PDGFRA Gene Mutation
PDGFRalpha Protein Overexpression
PTEN Gene Inactivation

EGFR Gene Amplification || EGFR Protein Overexpression || TP53 Gene Inactivation || MDM2 Gene Amplification || PDGFRA Gene Mutation || PDGFRalpha Protein Overexpression || PTEN Gene Inactivation


Stage IIB Small Intestinal Adenocarcinoma AJCC v8

Microsatellite Instability
CTNNB1 Gene Mutation
SMAD4/DPC4 Gene Inactivation
TP53 Gene Inactivation
KRAS Gene Mutation
Loss of E-cadherin Expression

Microsatellite Instability || CTNNB1 Gene Mutation || SMAD4/DPC4 Gene Inactivation || TP53 Gene Inactivation || KRAS Gene Mutation || Loss of E-cadherin Expression


Ciliary Body Teratoid Medulloepithelioma


Refractory High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements


Stage IIA Small Intestinal Adenocarcinoma AJCC v8


Ann Arbor Stage II Contiguous Adult Lymphoblastic Lymphoma

Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


RB1 Gene Inactivation
FOS Gene Amplification

RB1 Gene Inactivation || FOS Gene Amplification


GNAQ Gene Mutation
GNA11 Gene Mutation
CYSLTR2 Gene Mutation
PLCB4 Gene Mutation

GNAQ Gene Mutation || GNA11 Gene Mutation || CYSLTR2 Gene Mutation || PLCB4 Gene Mutation


Clonal CCND1 Gene Rearrangement
CCND1 Protein Overexpression

Clonal CCND1 Gene Rearrangement || CCND1 Protein Overexpression


BRAF Gene Mutation
TP53 Gene Inactivation
APC Gene Inactivation
KRAS Gene Amplification
MYC Gene Mutation

BRAF Gene Mutation || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


TP53 Gene Inactivation
APC Gene Inactivation
FHIT Gene Inactivation
KRAS Gene Amplification
LKB1 Gene Inactivation
EGFR Gene Mutation

TP53 Gene Inactivation || APC Gene Inactivation || FHIT Gene Inactivation || KRAS Gene Amplification || LKB1 Gene Inactivation || EGFR Gene Mutation


Peripheral Primitive Neuroectodermal Tumor of Bone

EWSR1-ETV4 Fusion Protein Expression
EWSR1-ERG Fusion Protein Expression
EWSR1-ETV1 Fusion Protein Expression
EWSR1-FEV Fusion Protein Expression
EWSR1-PATZ1 Fusion Protein Expression
FUS-ERG Fusion Protein Expression
EWSR1-FLI1 Fusion Protein Expression

EWSR1-ETV4 Fusion Protein Expression || EWSR1-ERG Fusion Protein Expression || EWSR1-ETV1 Fusion Protein Expression || EWSR1-FEV Fusion Protein Expression || EWSR1-PATZ1 Fusion Protein Expression || FUS-ERG Fusion Protein Expression || EWSR1-FLI1 Fusion Protein Expression


Prostate Acinar Adenocarcinoma, Pseudohyperplastic Variant

TP53 Gene Inactivation
PTEN Gene Inactivation
TMPRSS2-ERG Fusion Protein Expression
ERG Gene Rearrangement

TP53 Gene Inactivation || PTEN Gene Inactivation || TMPRSS2-ERG Fusion Protein Expression || ERG Gene Rearrangement


Recurrent B Acute Lymphoblastic Leukemia

Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement || Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


Laryngeal Acantholytic Squamous Cell Carcinoma


Ann Arbor Stage II Grade 1 Contiguous Follicular Lymphoma

Clonal BCL2 Gene Rearrangement
Clonal BCL6 Gene Rearrangement

Clonal BCL2 Gene Rearrangement || Clonal BCL6 Gene Rearrangement


Bladder Non-Invasive Papillary Urothelial Carcinoma, Low Grade


ERBB2 Gene Amplification
TP53 Gene Inactivation
MYC Gene Amplification
FHIT Gene Inactivation

ERBB2 Gene Amplification || TP53 Gene Inactivation || MYC Gene Amplification || FHIT Gene Inactivation


Microsatellite Instability
CDH1 Gene Inactivation
ERBB2 Gene Amplification
TP53 Gene Inactivation
APC Gene Inactivation
c-MET Gene Amplification

Microsatellite Instability || CDH1 Gene Inactivation || ERBB2 Gene Amplification || TP53 Gene Inactivation || APC Gene Inactivation || c-MET Gene Amplification


GNAQ Gene Mutation
GNA11 Gene Mutation
BAP1 Gene Mutation
SF3B1 Gene Mutation
CYSLTR2 Gene Mutation
PLCB4 Gene Mutation
EIF1AX Gene Mutation

GNAQ Gene Mutation || GNA11 Gene Mutation || BAP1 Gene Mutation || SF3B1 Gene Mutation || CYSLTR2 Gene Mutation || PLCB4 Gene Mutation || EIF1AX Gene Mutation


PDGFRA Gene Mutation || KIT Gene Mutation


TMPRSS2-ERG Fusion Protein Expression
ERG Gene Rearrangement

TMPRSS2-ERG Fusion Protein Expression || ERG Gene Rearrangement


Polymerase Proofreading Associated Polyposis

POLE Gene Mutation || POLD1 Gene Mutation


Helicobacter Pylori-Related Gastric Adenocarcinoma


Infiltrating Bladder Urothelial Carcinoma, Lymphoma-Like Variant

CCND1 Gene Amplification
CCND1 Protein Overexpression
EGFR Gene Amplification
EGFR Protein Overexpression
ERBB2 Gene Amplification
HRAS Gene Amplification
RB1 Gene Inactivation
TP53 Gene Inactivation
ERBB2 Protein Overexpression
MDM2 Gene Amplification

CCND1 Gene Amplification || CCND1 Protein Overexpression || EGFR Gene Amplification || EGFR Protein Overexpression || ERBB2 Gene Amplification || HRAS Gene Amplification || RB1 Gene Inactivation || TP53 Gene Inactivation || ERBB2 Protein Overexpression || MDM2 Gene Amplification


Indolent T-Cell Lymphoproliferative Disorder of the Gastrointestinal Tract

Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement


Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8

TP53 Gene Inactivation
MDM2 Gene Mutation

TP53 Gene Inactivation || MDM2 Gene Mutation


BRAF Gene Mutation || High-Frequency Microsatellite Instability || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


Stage III Adrenal Cortex Carcinoma AJCC v8


Peritoneal Gastrointestinal Stromal Tumor


TP53 Gene Inactivation
EGFR Gene Mutation

TP53 Gene Inactivation || EGFR Gene Mutation


Stage II Thyroid Gland Follicular Carcinoma Under 55 Years AJCC v8

NRAS Gene Mutation
PTEN Gene Inactivation
PPARG Gene Rearrangement
HRAS Gene Mutation
PIK3CA Gene Mutation
TERT Gene Mutation

NRAS Gene Mutation || PTEN Gene Inactivation || PPARG Gene Rearrangement || HRAS Gene Mutation || PIK3CA Gene Mutation || TERT Gene Mutation


Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma

Apoptotic Pathway Deregulation || Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement || Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement || Clonal T-Cell Receptor Gene Rearrangement


EGFR Gene Amplification
EGFR Protein Overexpression
TP53 Gene Inactivation
MDM2 Gene Amplification
PDGFRA Gene Mutation
PDGFRalpha Protein Overexpression
PTEN Gene Inactivation

EGFR Gene Amplification || EGFR Protein Overexpression || TP53 Gene Inactivation || MDM2 Gene Amplification || PDGFRA Gene Mutation || PDGFRalpha Protein Overexpression || PTEN Gene Inactivation


Esophageal Adenocarcinoma by AJCC v8 Clinical Stage

CDKN2A Gene Inactivation
EGFR Gene Amplification
ERBB2 Gene Amplification
TP53 Gene Inactivation
APC Gene Inactivation
FHIT Gene Inactivation
Loss of E-cadherin Expression

CDKN2A Gene Inactivation || EGFR Gene Amplification || ERBB2 Gene Amplification || TP53 Gene Inactivation || APC Gene Inactivation || FHIT Gene Inactivation || Loss of E-cadherin Expression


Pleural Malignant Mesothelioma by AJCC v7 Stage

CDKN2A Gene Inactivation
GPC3 Gene Inactivation
NF2 Gene Mutation

CDKN2A Gene Inactivation || GPC3 Gene Inactivation || NF2 Gene Mutation


Posterior Tongue Adenoid Cystic Carcinoma


SS18-SSX1 Fusion Protein Expression
SS18-SSX2 Fusion Protein Expression
SS18-SSX4 Fusion Protein Expression

SS18-SSX1 Fusion Protein Expression || SS18-SSX2 Fusion Protein Expression || SS18-SSX4 Fusion Protein Expression


CDKN2A Gene Inactivation || Clonal T-Cell Receptor Beta Chain Gene Rearrangement || Clonal T-Cell Receptor Gamma Chain Gene Rearrangement || PTEN Gene Inactivation


Stage IVC Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7

CDKN2A Gene Inactivation
RASSF1A Gene Inactivation

CDKN2A Gene Inactivation || RASSF1A Gene Inactivation


MDM2 Gene Amplification
PDGFRA Gene Amplification

MDM2 Gene Amplification || PDGFRA Gene Amplification


Metastatic Thyroid Gland Papillary Carcinoma

NRAS Gene Mutation
KRAS Gene Mutation
RET/PTC Rearrangement
NTRK1 Gene Rearrangement
HRAS Gene Mutation
BRAF NP_004324.2:p.V600E

NRAS Gene Mutation || KRAS Gene Mutation || RET/PTC Rearrangement || NTRK1 Gene Rearrangement || HRAS Gene Mutation || BRAF NP_004324.2:p.V600E


Recurrent Mixed Cellularity Classic Hodgkin Lymphoma

Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement


CCND1 Gene Amplification
Cyclin D1 Messenger RNA Overexpression
CCND1 Protein Overexpression
ERBB2 Gene Amplification
TP53 Gene Inactivation
ERBB2 Protein Overexpression

CCND1 Gene Amplification || Cyclin D1 Messenger RNA Overexpression || CCND1 Protein Overexpression || ERBB2 Gene Amplification || TP53 Gene Inactivation || ERBB2 Protein Overexpression


TP53 Gene Inactivation
MYC Gene Amplification

TP53 Gene Inactivation || MYC Gene Amplification


Low Grade Mucoepidermoid Breast Carcinoma


NRAS Gene Mutation
KRAS Gene Mutation
HRAS Gene Mutation

NRAS Gene Mutation || KRAS Gene Mutation || HRAS Gene Mutation


HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Clonal Immunoglobulin Heavy Chain Gene Rearrangement || Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement


Stage IIB Esophageal Adenocarcinoma AJCC v7


Stage IV Adrenal Cortex Carcinoma AJCC v8


BRAF Gene Mutation
TP53 Gene Inactivation
APC Gene Inactivation
KRAS Gene Amplification
MYC Gene Mutation

BRAF Gene Mutation || TP53 Gene Inactivation || APC Gene Inactivation || KRAS Gene Amplification || MYC Gene Mutation


Ovarian Small Cell Carcinoma, Pulmonary-Type


Refractory Esophageal Squamous Cell Carcinoma

Aneuploidy
CCND1 Gene Amplification
CDKN2A Gene Inactivation
EGFR Gene Amplification
FGF4 Gene Amplification
FGF6 Gene Amplification
TP53 Gene Inactivation
MYC Gene Amplification
FHIT Gene Inactivation

Aneuploidy || CCND1 Gene Amplification || CDKN2A Gene Inactivation || EGFR Gene Amplification || FGF4 Gene Amplification || FGF6 Gene Amplification || TP53 Gene Inactivation || MYC Gene Amplification || FHIT Gene Inactivation


Unresectable Cervical Squamous Cell Carcinoma, Not Otherwise Specified

ERBB2 Gene Amplification
TP53 Gene Inactivation
MYC Gene Amplification
FHIT Gene Inactivation

ERBB2 Gene Amplification || TP53 Gene Inactivation || MYC Gene Amplification || FHIT Gene Inactivation