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35,700,125 | applic amyloidtauneurodegener framework cognit intact adult cabl studi amyloidtauneurodegener n framework conceptu alzheim diseas ad continuum continuum diseas evid amyloid relat patholog independ clinic manifest base framework necessari reveal distribut risk factor ad continuum cognit intact popul among differ cohort race includ northern chines han popul | D000544;D060825 | T047;T048 |
35,700,123 | diabet neuropathi general phenomenon impact hand function perform qualiti life diabet sensorimotor peripher neuropathi usual consid affect predomin lower limb n wherea impact upper limb neuropathi ul n hand function perform qualiti life qol evalu systemat studi aim investig preval characterist ul n function psychosoci consequ type diabet | D003924;D003929 | T047 |
35,700,122 | illicit drug use male barroom aggress among member australian construct industri associ person masculin factor illicit drug use found increas risk male barroom aggress mba person trait disposit aggress associ illicit substanc use aggress behaviour along social normat masculin factor present studi assess relationship illicit drug use key person trait aggress impuls narciss masculin conform masculin norm male honour variabl physic mba perpetr victimis among male australian construct worker | D000697;D060389;D013287;D019966 | T131;T121;T090;T109;T048;T033 |
35,700,120 | ggc repeat expans rilpl associ oculopharyngodist myopathi oculopharyngodist myopathi opdm adult onset neuromuscular diseas character progress ptosi dysarthria ophthalmoplegia distal muscl weak recent studi reveal ggc repeat expans utr lrp gipc notchnlc associ opdm despit advanc approxim opdm patient remain genet undiagnos herein aim investig genet basi undiagnos opdm patient two unrel chines han famili | D009136 | T047 |
35,700,119 | growth depend design constraint transcript factor base metabolit biosensor metabolit biosensor base metabolit respons transcript factor key synthet biolog compon sens precis control cellular metabol biosensor often design laboratori condit deploy applic cellular growth rate differ drastic initi character ask growth rate impact minimum maximum biosensor output dynam rang key metric biosensor perform use laci tetr fadr base biosensor escherichia coli model find dynam rang differ biosensor differ growth rate depend develop kinet model explor tune biosensor paramet impact dynam rang growth rate depend model experiment result reveal effect dynam rang growth rate depend often coupl metabolit transport mechan shape dynam rang growth rate respons work provid systemat understand biosensor perform differ growth rate use predict biosensor behavior broad synthet biolog metabol engin applic | D015374;D014157 | T059;T075;T123;T116 |
35,700,118 | pseudogen pose problem metabarcod marin anim communiti dna metabarcod typic employ sequenc divers among mitochondri amplicon estim speci composit nuclear mitochondri pseudogen numt inflat divers studi quantifi incid attribut numt deriv bp barcod region cytochrom c oxidas coi marin anim genom numt examin ascertain could recogn possess indel stop codon total numt bp detect averag per speci rang mean length bp among total lack indel stop codon numt appear pose greatest interpret risk short bp amplicon use environment dna studi dietari analys process fish identif employ standard amplicon length bp marin metabarcod numt could potenti inflat oper taxonom unit otu count true speci count also rais intraspecif variat coi howev amplicon length posit consid inflat otu count barcod variat respect suggest numt serious distort biodivers assess weak posit correl genom size numt count variat among phyla trophic group bioinformat advanc improv numt detect best defenc involv target long amplicon develop refer databas includ mitochondri sequenc numt deriv | D000080309;D011544 | T028;T114 |
35,700,117 | effect dibutyl phthalat di ethylhexyl phthalat hepat structur function adult male mice object present research determin dibutyl phthalat dbp di ethylhexyl phthalat dehp alon combin exposur induc patholog alter laboratori rear albino mice adult male mice equal divid n control corn oil co dbp dehp dbpdehp treat group dibutyl phthalat mgkg dehp mgkg dbpdehp mgkg respect administ oral gavag mix corn oil ml day anim sacrif follow day treatment blood collect serum lipid profil liver function test liver sampl also collect observ histolog chang microphotograph hematoxylin eosin stain section use comput base micrometri co dbp dehp dbpdehp treatment result signific increas mean bodi liver weight compar control group histolog examin liver dbp andor dehp treatment show mark alter lead hepat hypertrophi treat group signific increas mean number mononucl binucl cell oval cell per unit area notic disorgan trabecular arrang compar control group treatment dbp andor dehp result larg regener zone liver increas relat nucleo cytoplasm index mononuclear shepatocyt compar control group treatment caus signific increas liver enzym protein well alter serum cholesterol triglycerid ldl vldl level histopatholog serolog find confirm toxic potenti hepat tissu dbp dehp either given alon combin | D004051;D010795 | T109;T122 |
35,700,115 | qualit assess patient satisfact remot dermatolog consult util uk first wave covid pandem singl secondari care dermatolog depart first wave sar cov coronavirus covid pandem mani dermatolog depart uk deliv remot consult order minim viral transmiss assess patient percept remot consult deliv singl dermatolog depart time retrospect contact patient via electron questionnair respons summar anticip increas use remot consult legaci pandem although healthcar profession respons ensur appropri patient suitabl | D000086382;D003880 | T047;T091;T067 |
35,700,114 | clinic util prognost implic af scheme report asia pacif heart rhythm societi atrial fibril registri af classif scheme compris four domain stroke risk st symptom sy sever atrial fibril af burden sb substrat su recommend esc guidelin character evalu patient af | D001281;D002545;D020521 | T047;T046 |
35,700,113 | effect direct act antivir agent lipid glucos profil hcv patient type diabet real life italian experi hepat c virus hcv infect associ increas risk type diabet mellitus tdm cardiovascular diseas impact hcv erad metabol profil diabet patient treat direct act antivir agent daa well defin aim studi evalu effect daa lipid glucos profil cohort diabet patient differ liver fibrot stage | D003924;D019698 | T047 |
35,700,112 | rsha mutat contribut tigecyclin resist mycobacteroid abscessus tigecyclin import rescu antibiot mani bacteri infect mycobacteroid abscessus tigecyclin resist associ dysregul stress respons caus aberr interact sigh rsha factor studi two tigecyclin resist mutant abscessus cla cla mutat rsha gene studi use gene complement rt qpcr bacteri adenyl cyclas two hybrid bacth system result support premis mutat rsha interrupt rsha sigh interact caus overexpress sigh gene lead tigecyclin resist reduc suscept | D009165;D000073358 | T007;T047 |
35,700,110 | genet characterist azithromycin resist neisseria gonorrhoea collect hyogo japan introduct azithromycin azm therapeut drug sexual transmit infect use neisseria gonorrhoea first second line drug avail recent suscept n gonorrhoea azm decreas worldwid hypothesisgap statement azithromycin resist azm r rate among n gonorrhoea japan increas gene mutat epidemiolog characterist azm r n gonorrhoea fulli investig aim determin suscept azm correl genet characterist n gonorrhoea methodolog investig suscept azm genet characterist n gonorrhoea mutat domain v rrna gene mtrr examin isol includ azm r isol spread clonal examin use sequenc type sts multi antigen sequenc type n gonorrhoea ng mast whole genom analysi wga identifi singl nucleotid polymorph result number azm r isol increas gradual hyogo p ct mutat rrna signific increas azm r isol p ng mast st st frequent detect azm r isol higher mic azm gml phylogen tree base wga show isol st contain clade isol st divid two clade azm isol azm r isol differ cluster contain st conclus studi show year increas azm r rate n gonorrhoea ng mast st st detect previous studi frequent identifi isol higher mic azm wga confirm isol sts close relat continu surveil need detect emerg confirm spread ng mast st st | D006069;D009344 | T007;T047 |
35,700,109 | tannin phenotyp vitacea reveal phylogenet linkag epigallocatechin berri leav condens tannin respons berri wine astring may select grapevin domest work examin phylogenet distribut condens tannin throughout vitacea phylogenet tree | D044945;D027844;D027843 | T116;T002;T121;T109;T168;T129 |
35,700,108 | kaposiform haemangioendothelioma success treat topic tacrolimus compress bandag report patient kaposiform haemangioendothelioma success treat topic tacrolimus compress bandag | D006390;D059885;D012514 | T191;T047 |
35,700,107 | effect optic disc tilt measur peripapillari vessel densiti use optic coher tomographi angiographi eye tilt disc td signific lower peripapillari vessel densiti pvd lower long term measur reproduc optic coher tomographi angiographi octa adjust confound factor disc tilt still contribut reduct pvd sector | D009898 | T023;T033 |
35,700,106 | short term efficaci safeti open conjunctiva ab externo xen gel stent implant glaucoma patient examin safeti efficaci open conjunctiva ab externo approach xen gel stent implant signific reduct intraocular pressur iop number glaucoma medic month follow | D005901;D020327;D014130 | T061;T047;T074 |
35,700,105 | comparison vascular densiti structur pattern primari open angl glaucoma primari angl closur glaucoma compar pattern vascular densiti structur damag primari open angl glaucoma poag primari angl closur glaucoma pacg use optic coher tomographi oct oct angiographi octa optic nerv head circumpapillari macular region respect | D015812;D005902;D009898 | T047;T023;T033 |
35,700,104 | train silverman andersen score improv special care unit nurs assess neonat respiratori distress low resourc set identifi sever neonat respiratori distress rd essenti resourc appropri alloc assess abil nurs grade neonat rd low resourc set train use dedic score tool | D012127;D012131 | T047;T046 |
35,700,103 | identif activ speci bimetal cluster catalyz hydrogen identif authent activ speci cluster catalysi rather challeng direct structur evid quit valuabl difficult obtain two isostructur cluster ag cu cl dppb phcc cf ag cu cl h dppb phcc cf h dppb bis diphenylphosphin butan success isol structur character cluster center icosahedron ag core peripher composit structur differ h eight hydrid none kernel ag ag h h respect catalyt reduct nitrophenol np aminophenol ap model reaction assess two cluster cluster h activ yield within h wherea show low convers condit interest high catalyt activ observ convert h oxid h catalyt condit unpreced transform reduc nanoclust ag cu bimetal cluster compound provid excel platform determin real activ cluster term metal cluster catalysi present work present clear structur evid catalyt perform metal nanoclust modul proper regul oxid state constitut metal atom | D006046;D006861 | T121;T196;T130;T197 |
35,700,102 | fatti acid metabol cell function differenti immunometabol recent emerg field studi examin intersect immunolog metabol studi area yield new find role divers rang metabol pathway metabolit found control mani aspect cell biolog includ cell differenti function fate particular import find discoveri meet energi requir associ prolifer activ specif function cell switch metabol signatur differenti exampl wherea induct de novo fatti acid biosynthesi fatti acid uptak program requir antigen stimul induc prolifer differenti effector cell fatti acid catabol via oxid essenti generat memori cell differenti regulatori cell review discuss recent advanc understand metabol differ stage cell fatti acid metabol cell control specif function | D005227;D050378 | T025;T109;T123;T168 |
35,700,101 | end seal peptid nanotub cation amphiphil polypeptid salt respons accordion like open close behavior one strategi prepar phase separ co assembl use exist assembl platform architect structur purpos edg sheet tube shape molecular assembl less hydrophil bulk region becom start point build assembl unit realiz complex structur studi succeed prepar rod shape nanocapsul previous unachiev seal effici fine tune properti cation amphiphil polypeptid seal end neutral charg nanotub addit demonstr nanocapsul revers respons salt high salt concentr decreas electrostat repuls cation polypeptid caus tear shrink nanocapsul seal dome result open nanotub hand salt remov electrostat repuls among cation peptid local edg open nanocapsul recov seal membran swell like accordion creat distanc peptid result restor seal | D053769;D043942;D045333 | T116;T073 |
35,700,100 | carbon dot hydroxi fluorid achiev multicolor long wavelength room temperatur phosphoresc excel stabil via crystal confin carbon dot cds arous widespread interest construct room temperatur phosphoresc rtp materi howev great challeng obtain simultan multicolor long wavelength rtp emiss excel stabil cd base rtp materi herein novel univers cds yohf strategi propos generat multicolor long wavelength rtp confin various cds oh x f x yohf matrix mechan triplet emiss cds relat space confin format hydrogen bond c f bond electron withdraw fluorin atom remark rtp lifetim orang emiss cds yohf longest among report singl cd matrix composit emiss nm furthermor cds yohf exhibit higher rtp perform long wavelength comparison cds matrix matrix pva pu urea silica result cds yohf show excel photost thermost chemic stabil tempor stabil rather favor inform secur especi complex environ | D002244;D045663 | T121;T196;T073 |
35,700,097 | novel maiz microrna negat regul resist fusarium verticillioid although microrna mirna regul defenc respons multipl pathogen fungi divers plant speci effort devot deciph involv mirna resist fusarium verticillioid major pathogen fungus affect maiz product studi discov novel f verticillioid respons mirna design zma unmir maiz kernel express zma unmir signific repress resist maiz line induc suscept line upon exposur f verticillioid exposur wherea target gene zmgaox exhibit opposit pattern express heterolog overexpress zma unmir arabidopsi result enhanc growth compromis resist f verticillioid contrast transgen plant overexpress zmgaox homologu atgaox show impair growth enhanc resist f verticillioid moreov zma unmir mediat suppress atgaox disturb accumul bioactiv gibberellin ga transgen plant perturb express set defenc relat gene respons f verticillioid exogen applic ga ga biosynthesi inhibitor modul f verticillioid resist differ plant taken togeth result suggest zma unmir zmgaox modul might act major player balanc growth resist f verticillioid maiz | D037341;D005670;D035683 | T131;T109;T123;T114;T004 |
35,700,094 | paperless precept develop electron compet assess tool articl present process har technolog develop structur consist compet base orient program across larg health system electron initi compet assess tool provid conveni access standard practic resourc track complet initi compet implement tool provid nurs profession develop practition effici align across clinic area effect resourc util | D002983;D004581 | T090;T080 |
35,700,093 | surgic realign anterior multilevel decompress use cage plate level level degen fusion lesson learn analysi geometr chang reciproc coupl predict sagitt cervic balanc retrospect singl center case studi | D007738;D008141 | T047;T190 |
35,700,092 | alkb rna demethylas homologu n methyladenosin involv potyvirus infect protein alkyl b alkb superfamili show rna demethylas activ remov methyl adduct n methyladenosin revers epigenet mark rna regul human virus replic unclear role plant virus infect focus potyvirus largest genus plant rna virus report identif alkb domain within p endiv necrot mosaic virus enmv addit virus putat novel speci within potyvirus show nicotiana benthamiana level reduc infect plum pox virus ppv potato virus pvi two potyvirus lack alkb result suggest general involv rna methyl potyvirus infect evolut methyl rna immunoprecipit sequenc virus infect sampl show peak enrich plant transcript untransl region discret intern termin region ppv pvi genom regul n benthamiana alkb homologu plant specif alkbh clade caus signific decreas ppv pvi accumul summari studi provid evolutionari experiment evid support implic provir role alkb homologu potyvirus infect | D010942;D017801;D017800 | T005 |
35,700,090 | aspirin may suitabl prophylaxi patient histori venous thromboembol undergo total joint arthroplasti recent year aspirin becom popular agent venous thromboembol vte prophylaxi follow total joint arthroplasti tja yet patient histori vte often given aggress prophylact agent increas baselin risk purpos studi assess whether aspirin effect prophylact agent patient histori vte | D019644;D054556 | T061;T047 |
35,700,089 | pain catastroph predict opioid health care util orthopaed surgeri secondari analysi trial particip spine lower extrem disord individu undergo elect surgeri expect discontinu opioid use surgeri mani modifi risk factor includ psychosoci factor associ poor postsurg outcom want know whether pain catastroph specif associ postsurg opioid health care use | D009293;D019637;D015207;D020370 | T061;T047;T048 |
35,700,088 | intramolecular interrupt homo nazarov cascad biscycl angular hetero aryl fuse polycycl herein sncl catalyz intramolecular interrupt homo nazarov cascad biscycl access angular hetero aryl fuse polycycl report subsequ decarboxyl readili enoliz product afford angular product yield two step tran diastereom major product cyclopropyl homo nazarov cyclize precursor form use scalabl modular synthet rout ultim offer access fuse angular polycycl product showcas rigor util method step total synthesi oxoferruginol antibacteri aromat abietan diterpenoid disclos | D045784;D000900 | T121;T109;T195 |
35,700,087 | modifi scarf osteotomi medial capsular interposit combin metatars shorten offset osteotomi comparison patient noninflammatori arthriti rheumatoid arthriti foot patient noninflammatori arthriti feet may develop destruct chang first metatars head pain disloc metatarsophalang mtp joint lesser toe aim studi compar feet noninflammatori arthriti rheumatoid arthriti ra respect clinic radiograph outcom treatment destruct deform modifi scarf osteotomi medial capsular interposit newli form first mtp joint combin metatars shorten offset osteotomi | D001172;D006215;D008682;D008683 | T047;T030;T190;T023 |
35,700,084 | nonop manag follow complet respons rectal cancer short cours radiat therapi consolid chemotherapi clinic outcom qualiti life measur purpos studi report cohort patient manag nonop manag nom watch wait strategi achiev complet respons cr sequenti short cours radiat therapi scrt consolid chemotherapi | D012004 | T191 |
35,700,082 | age younger affect clinic outcom medicar patient undergo lumbar fusion retrospect cohort studi | D013123 | T061 |
35,700,081 | phase studi apolizumab anti hla dr chain monoclon antibodi patient solid tumor malign human leukocyt antigen hla dr member major histocompat complex class ii antigen famili target antibodi base therapeut apolizumab hud remitogen human igg monoclon anti hla dr chain antibodi target antigen express wide varieti hematolog solid tumor malign phase trial maximum toler dose dose limit toxic week apolizumab patient advanc solid tumor malign determin | D002292;D007680;D009369 | T191 |
35,700,080 | tele medicin improv mental health problem covid pandem systemat review tele medicin servic develop respons covid pandem disrupt mental health servic present studi investig effect telephon deliv servic psycholog disord covid pandem | D000086382;D001523;D017216 | T047;T058;T067;T048 |
35,700,079 | practic method epr dosimetri use alanin powder work investig alanin powder inexpens versatil materi compar alanin pellet standard dosimet alanin epr system use bruker emx micro spectromet feasibl method investig calibr curv produc use dosimet prepar tight pack dl alanin powder polypropylen microcentrifug tube dosimet irradi dose rang gy use co sourc dosimet handl measur protocol establish dosimet dosimetr signal evalu measur peak peak height central reson peak dose respons alanin powder dosimet show linear behavior investig dose rang relat error measur repeat reproduc test show error associ sampl placement caviti overal measur method test show relat error inexpens materi compar pellet dosimet alanin powder strong potenti use standard materi radiat dosimetri applic scope work present effect comprehens methodolog accompani analysi script dosimetri alanin powder use wide rang applic dose requir | D000409;D011874 | T116;T073;T059;T074;T121;T123 |
35,700,074 | trend primari gallbladd cancer incid incid base mortal unit state primari gallbladd cancer gbc common biliari tract cancer poor surviv despit aggress treatment studi aim investig trend gbc incid incid base mortal ibm last decad | D001661;D005706 | T191 |
35,700,073 | total hip arthroplasti lead better result low energi displac femor neck fractur patient age year random control multicent trial compar intern fixat total hip arthroplasti optim treatment displac femor neck fractur patient year old remain controversi aim present studi assess effect close reduct intern fixat cannul screw compar total hip arthroplasti tha hip pain function use data outcom measur complic reoper | D019644;D005265 | T061;T037 |
35,700,072 | select iron catalyz synthesi n alkyl indolin indol wherea iron catalyst usual promot catalyz c alkyl indol deriv via borrow hydrogen methodolog use alcohol electrophil partner contribut show switch select toward n alkyl thus start indolin deriv n alkyl effici perform use tricarbonyl cyclopentadienon iron complex catalyst trifluoroethanol presenc alcohol lead correspond n alkyl indolin deriv yield exampl one pot two step strategi select n alkyl indolin complet oxid give correspond n alkyl indol yield exampl unpreced oxid methodolog involv iron salt catalyst associ tetramethylpiperidin yl oxyl tempo stoichiometr amount buooh room temperatur | D007501;D014270 | T121;T109;T123;T196 |
35,700,071 | identifi investig ambulatori care sequenc invas coronari angiographi concept care pathway wide use provid effici time evid base medic care recent investig actual empir patient pathway gain attent demonstr usabl state sequenc analysi ssa data mine approach base sequenc cluster techniqu comprehens insur claim data germani identifi empir ambulatori care sequenc investig patient coronari arteri diseas invas coronari angiographi ca compar identifi pattern guidelin recommend patient group particular interest due high region vari ca rate | D003324 | T047 |
35,700,069 | second line immunotherapi function outcom autoimmun enceph systemat review individu patient data meta analysi autoimmun enceph ae neurolog disord caus autoimmun attack cerebr protein expert current recommend stage immunotherapeut manag first line immunotherapi follow second line immunotherapi respons first line therapi inadequ meta analysi evid base may provid higher qualiti evid support recommend undertook systemat review observ cohort studi report ae patient treat either second line immunotherapi first line immunotherapi alon outcom report use modifi rankin scale mrs search date april perform sever one stage multilevel individu patient data ipd meta analys examin associ second line immunotherapi final mrs score prospero id crd ipd obtain patient studi studi rate moder high risk bias seventi one patient treat second line immunotherapi find statist signific associ treatment second line immunotherapi final mrs score cohort overal odd ratio confid interv ci p subgroup anti n methyl aspart receptor enceph ci p sever ae maximum mrs score ci p treatment second line immunotherapi associ higher final mrs score subgroup anti leucin rich glioma inactiv ae ci p long term least month follow ci p observ associ treatment second line immunotherapi lower final mrs score patient ae result interpret caution given risk bias limit adjust diseas sever insensit mrs estim psychiatr cognit disabl | D060426;D050031 | T047 |
35,700,067 | uvb drive metabol rewir epigenet reprogram protect sulforaphan human skin keratinocyt sulforaphan sfn potent anticanc agent could protect skin ultraviolet uv radiat induc insult current metabol rewir epigenet reprogram induc uvb role sfn uvb mediat skin cell transform remain larg unknown herein studi metabolom epigenom transcriptom human keratinocyt hacat cell expos uvb without sfn use liquid chromatographi mass spectroscopi dna methyl sequenc rna sequenc uvb increas intracellular reactiv oxygen speci ros sfn enhanc ros acut post uvb expos hacat cell uvb sfn alter multipl metabolit metabol relat signal pathway pathway analysi show uvb impact numer signal pathway includ stat inhibit matrix metalloproteas tgf among other dnacpg methyl analysi show sfn could partial revers alter uvb induc cpg methylom integr rna seq methyl seq data starburst plot show correl mrna express cpg methyl status potenti linkag metabolom cpg methylom transcriptom suggest metabolit produc metabol act cofactor substrat catalyt epigenet modif transcript regul result indic uvb drive metabol rewir epigenet reprogram phenotyp transcriptom alter sfn would block attenu mani aberr potenti contribut overal protect effect sfn uvb induc skin damag | D017879;D015603 | T025;T109 |
35,700,066 | calcitonin gene relat peptid intra articular therapeut target tmj disord goal project evalu role calcitonin gene relat peptid cgrp develop arthriti | D015740;D013705 | T047;T116;T125 |
35,700,064 | short term exposur wildfir smoke pm cognit perform brain train game longitudin studi us adult increas evid long term exposur fine particul matter pm aerodynam diamet pm may advers impact cognit perform wildfir smoke one biggest sourc pm concentr like increas climat chang howev littl known short term exposur impact cognit function | D000393;D000075923 | T131;T070 |
35,700,062 | tetracyclin induc releas oxid iii coupl concomit ferrihydrit transform cocontamin tetracyclin tc arsenic common paddi field howev process under mechan arsenit iii transform iron miner surfac presenc antibiot contamin remain unclear studi releas oxid iii ferrihydrit fh surfac fh transform presenc tc aerob anaerob condit investig result indic tc induc reduct dissolut fh fe ii releas tc competit adsorpt signific promot releas especi anaerob condit releas increas increas tc concentr wherea decreas increas ph interest aerob anaerob condit addit tc enhanc oxid iii fh induc partial transform fh lepidocrocit aerob condit adsorb fe ii activ product reactiv oxygen speci oh dissolv fe iv respons iii oxid anaerob condit abund oxygen vacanc fh affect oxid iii fh recrystal thus studi provid new insight role tc migrat transform coupl fe soil | D001151 | T121;T131;T196 |
35,700,059 | keloid area sever index kasi object tool evalu keloid aid standard evalu patient multipl keloid keloid area sever index kasi develop use patient feedback previous literatur clinic expertis system valid use intrarat interrat reliabl assess present verifi reliabl method assess keloid area sever clinic research set | D007627 | T020 |
35,700,057 | epcr par bias signal regul perfus recoveri neovascular peripher ischemia blood clot format initi ischem event coagul role postischem tissu repair poor understood endotheli protein c receptor epcr regul coagul well immun vascular signal proteas activ receptor par show endotheli epcr par signal support reperfus neovascular hindlimb ischemia mice wherea delet par par impair angiogenesi epcr par defici par resist cleavag activ protein c caus mark reduc postischem reperfus vivo angiogenesi vitro find corrobor bias par agon isol primari endotheli cell loss epcr par signal upregul hemoglobin express reduc endotheli nitric oxid bioavail defect angiogen sprout rescu donor deta wherea scaveng increas hemoglobin mesenchym marker express human mous endotheli cell vascular specimen patient ischem peripher arteri diseas exhibit increas hemoglobin express solubl epcr level reduc plasma data implic endotheli epcr par signal hypox respons endotheli cell identifi suppress hemoglobin express unexpect link coagul signal preserv endotheli cell bioavail support neovascular prevent fibrosi | D042783;D044463 | T025;T116;T192 |
35,700,056 | human midbrain dopaminerg neuron differenti marker predict cell therapi outcom parkinson diseas model human pluripot stem cell base hpsc base replac therapi hold great promis treatment parkinson diseas pd howev heterogen hpsc deriv donor cell low yield midbrain dopaminerg mda neuron transplant hinder broad clinic applic character singl cell molecular landscap mda neuron differenti found process recapitul develop multipl adjac fetal brain region includ ventral midbrain isthmus ventral hindbrain result heterogen donor cell popul reconstruct differenti trajectori mda lineag identifi calsyntenin clstn protein tyrosin phosphatas receptor type ptpro specif surfac marker mda progenitor predict mda neuron differenti could facilit high enrich mda neuron follow progenitor cell sort transplant marker sort progenitor exhibit higher therapeut potenc correct motor deficit pd mice differ marker sort graft strike consist cellular composit mda neuron enrich target neuron type most deplet suggest stabl graft outcom studi provid better understand cellular heterogen mda neuron differenti establish strategi generat high purifi donor cell achiev stabl predict therapeut outcom rais prospect hpsc base pd cell replac therapi | D010300 | T047 |
35,700,053 | disrupt dream complex enabl prolifer adult human pancreat cell resist regener insulin produc pancreat cell fundament challeng type type diabet recent small molecul inhibitor kinas dyrka proven effect induc adult human cell prolifer detail mechan action incomplet understood interrog human insulinoma cell transcriptom databas seek understand cell insulinoma prolifer normal cell search reveal dream complex central regul quiescenc human cell dream complex consist modul transcript repress protein assembl respons dyrka kinas activ therebi induc maintain cellular quiescenc absenc dyrka dream subunit reassembl pro prolif mmb complex demonstr small molecul dyrka inhibitor induc human cell replic convert repress dream complex pro prolif mmb conform | D003924;D050417;D007340;D010190 | T191;T047;T025 |
35,700,052 | women worth impact cash plus intervent enhanc attend reduc sexual health risk young women cape town south africa condit cash transfer cts augment intervent promis intervent reduc hiv risk adolesc girl young women | D015658;D000066511;D000074384 | T047;T053;T032 |
35,700,051 | effect chikv vaccin vla demonstr passiv transfer human sera chikungunya virus chikv reemerg mosquito born alphavirus respons numer outbreak chikungunya caus debilit acut chronic diseas thus develop safe effect chikv vaccin urgent global health prioriti studi evalu effect live attenu chikv vaccin vla wt chikv infect use passiv transfer sera vaccin volunt nonhuman primat nhp subsequ expos wt chikv establish serolog surrog protect demonstr human vla sera transfer nhps confer complet protect chikv viremia fever challeng homolog wt chikv addit serum transfer protect anim chikv associ clinic symptom chikv persist tissu base passiv transfer studi micro plaqu reduct neutral test titer determin surrog protect support analysi sampl seroepidemiolog studi conclus consid unfeas efficaci trial due unpredict explos rapid move natur chikungunya outbreak definit surrog protect vla import step toward vaccin licensur reduc medic burden caus chikungunya | D065632;D002646 | T047;T005 |
35,700,050 | stoichiometri versus ecolog relationship genom size guanin cytosin content tissu nitrogen phosphorus grassland herb plant tissu nitrogen n phosphorus p genom trait genom size guanin cytosin gc content scale growth metabol rate link plant ecolog strategi spectra tissu np stoichiometri genom trait report affect plant growth metabol rate ecolog strategi contrast way although element cost build maintain dna typic overlook | D009584;D010758 | T123;T197;T196 |
35,700,049 | return work follow anterior cruciat ligament reconstruct amongst peopl work age return work rtw anterior cruciat ligament acl reconstruct import marker success surgeri determin patient abl return work acl reconstruct identifi factor associ time rtw | D000070598;D059549 | T061;T037 |
35,700,048 | rate convers secondari arthroplasti femor neck fractur younger patient treat intern fixat swedish nation regist base studi younger patient femor neck fractur fnf intern fixat recommend treatment regardless displac heal complic often treat arthroplasti determin rate convers arthroplasti year fixat either undisplac fnfs ufnf displac fnfs dfnfs | D019644;D005265 | T061;T037 |
35,700,046 | ctnnd variant caus famili exud vitreoretinopathi wntcadherin axi famili exud vitreoretinopathi fevr hereditari disord caus vision loss ctnnd encod cellular adhes protein p catenin p essenti vascular unclear function postnat physiolog angiogenesi appli whole exom sequenc proband fevr famili identifi candid variant human ctnnd gene perform induc delet ctnnd postnat mous endotheli cell ec observ typic phenotyp fevr reactiv gliosi use unbias proteom analysi combin experiment approach conclud p critic integr adheren junction aj p activ wnt signal activ protect catenin glycogen synthas kinas beta ubiqutin guid gsk ubiquitin guid degrad treatment ctnnd deplet human retin microvascular ec gsk inhibitor licl chir enhanc cell prolifer moreov licl treatment increas vessel densiti ctnnd defici mous retina variant ctnnd caus fevr compromis express aj wnt signal activ genet interact p catenin catenin reveal doubl heterozyg delet mice show p regul vascular develop wntcadherin axi conclus variant ctnnd caus fevr wntcadherin axi | D015820;D051176 | T123;T116 |
35,700,045 | enantioselect synthesi enantioisotopom quantit chiral analysi chiral tag rotat spectroscopi fundament synthesi enantioenrich chiral molecul abil assign absolut configur stereogen center determin enantiomer excess compound determin enantiomer excess absolut configur often consid routin mani facet asymmetr synthesi determin enantioisotopom remain formid challeng report first high enantioselect metal catalyz synthesi enantioisotopom chiral virtu deuterium substitut along first general spectroscop techniqu assign absolut configur quantit determin enantiomer excess isotop chiral molecul chiral tag rotat spectroscopi use noncoval chiral derivat elimin possibl racem derivat perform chiral analysi without need refer sampl enantioisotopom | D013237 | T082;T104;T070 |
35,700,044 | prospect target cell immunoglobulin mucin domain contain renal cell carcinoma immunotherapi despit advanc diagnosi treatment renal cell carcinoma rcc remain one dead urolog cancer present use immun checkpoint inhibit combin antiangiogen therapi standard care patient advanc rcc unfortun consider part tumour bear host benefit type treatment howev knowledg detail role mucin domain contain tim rcc cell littl studi requir field signific express rcc microenviron make receptor promis target design new monoclon antibodi alon combin checkpoint inhibitor rcc immunotherapi | D002292;D000072597;D007680 | T191;T116;T192 |
35,700,043 | myeloid foxo deplet attenu hepat inflamm prevent nonalcohol steatohepat hepat inflamm culpabl evolut asymptomat steatosi nonalcohol steatohepat nash hepat inflamm result abnorm macrophag activ found foxo link overnutrit hepat inflamm regul macrophag polar activ foxo upregul hepat macrophag correl hepat inflamm steatosi fibrosi mice patient nash myeloid cell condit foxo knockout skew macrophag polar proinflammatori antiinflammatori phenotyp accompani reduct macrophag infiltr liver effect mitig overnutrit induc hepat inflamm insulin resist contribut improv hepat metabol increas energi expenditur myeloid cell foxo knockout mice high fat diet fed nash induc diet myeloid cell foxo knockout mice protect develop nash culmin reduct hepat inflamm steatosi fibrosi mechanist foxo counteract stat skew macrophag polar toward signatur perpetu hepat inflamm nash foxo appear pivot mediat macrophag activ respons overnutrit therapeut target amelior hepat inflamm stem diseas progress benign steatosi nash | D000071161;D065626;D044343 | T047;T123;T116 |
35,700,042 | oma mediat local global stress respons protein misfold chchd mitochondri myopathi mitochondri stress trigger respons cell mitochondria nucleus stress respons coordin vivo poor understood character famili myopathi caus domin pgr mutat mitochondri protein chchd understand diseas etiolog develop knockin ki mous model found mutant chchd aggreg affect tissu appli toxic protein stress inner mitochondri membran unexpect surviv chchd ki mice depend protect stress respons mediat mitochondri metalloendopeptidas oma oma stress respons act local within mitochondria caus mitochondri fragment signal outsid mitochondria activ integr stress respons cleavag dap bind cell death enhanc dele addit identifi isoform switch termin complex electron transport chain compon respons result demonstr oma critic neonat surviv condit set inner mitochondri membran stress coordin local global stress respons reshap mitochondri network proteom | D045726;D017240;D024101 | T047;T126;T116;T123 |
35,700,041 | morphometr imag quantit suscept map complementari tool diagnosi parkinson quest vivo diagnost biomark discrimin parkinson diseas pd progress supranuclear palsi psp multipl system atrophi msa main p phenotyp mani advanc magnet reson imag mri techniqu studi morphometr indic magnet reson parkinson index mrpi demonstr high diagnost valu comparison pd psp potenti quantit suscept map qsm hypothes increas magnet suscept report red nucleus rn medial part substantia nigra snime psp patient putamen msa patient howev diseas specif suscept valu relev region interest yet identifi aim studi evalu diagnost potenti multimod mri protocol combin morphometr qsm imag patient determin parkinson explor valu popul undetermin case | D019578;D010300;D020734;D013494 | T050;T047;T046 |
35,700,038 | genom wide associ studi pregnanc childhood cancer survivor report childhood cancer survivor studi gonadotox treatment relat infertil signific impact qualiti life childhood cancer survivor genom wide associ analys delin risk infertil childhood cancer survivor previous report | D000073116;D007246;D009369 | T046;T101;T191;T201;T033 |
35,700,037 | associ studi polymorph dna methyl relat gene testicular germ cell tumor risk testicular germ cell tumor tgct histolog classifi seminoma nonseminoma believ aris primordi gonocyt matur process block subject dna methyl reprogram snps dna methyl machineri folat depend one carbon metabol gene postul influenc proper establish dna methyl | D009373;D018239;D013736 | T191 |
35,700,034 | multipl myeloma polygen risk score predict overal surviv patient myeloma genom wide associ studi gwas multipl myeloma popul european ancestri ea identifi confirm suscept loci cancer eg colorectum melanoma risk loci also associ patient surviv | D055106;D009101 | T191;T063 |
35,700,033 | respons letter editor dr aa zulqar public multidimension short tool assess frailti narrat review ann ig mar doi ai onlin ahead print appreci dr zulfiqar show us alreadi demonstr valid reliabl zfs scale still evid paper could take grant articl quot publish hand manag editor ann ig | D000073496 | T046;T184;T033 |
35,700,032 | comment formosa v lorusso g lentini g terracciano e gentili liotta g multidimension short tool assess frailti narrat review ann ig mar doi ai onlin ahead print read paper formosa et al ann ig mar onlin ahead print author ask studi assess valid reliabl short tool evalu frailti propos letter intend demonstr valid reliabl prove seri applic alreadi publish last past month | D000073496 | T046;T184;T033 |
35,700,030 | covid knowledg attitud prevent measur univers student bahrain sever acut respiratori syndrom covid first report china decemb quick becam global pandem result million infect million death | D000086382 | T047;T067 |
35,700,029 | new tool assess risk fall children sever disabl develop alic scale known literatur main caus physic impair children sever disabl fall worsen alreadi compromis condit specif scale popul literatur neither italian languag creat valid scale assess risk fall children sever disabl | D006233 | T101 |
35,700,028 | challeng facilit health literaci patient acut coronari syndrom qualit studi low health literaci associ high preval cardiovascular diseas therefor studi carri identifi challeng health literaci strategi promot patient acut coronari syndrom use patient nurs experi | D054058;D057220 | T047;T041 |
35,700,027 | improv art initi among men use hiv self test malawi qualit studi hiv self test hivst increas hiv test uptak among men howev linkag antiretrovir therapi art among hivst user low innov strategi art initi need yet littl known uniqu barrier care experienc male hivst user art relat intervent men desir | D015658 | T047 |
35,700,024 | excess googl search child abus intim partner violenc covid pandem infoveil approach covid pandem creat environ increas risk factor household violenc unemploy financi uncertainti time led introduct polici mitig financi uncertainti hinder tradit measur household violenc | D000086382;D002649;D000066511 | T047;T053;T067;T048 |
35,700,022 | distribut hiv aid case luzhou china bayesian spatiotempor analysi vast increas number report hiv aid case luzhou china recent year coupl citi uniqu geograph locat intersect provinc make particular import conduct spatiotempor analysi hiv aid case | D000163 | T047 |
35,700,021 | emerg trend research foci artifici intellig retin diseas bibliometr visual studi patient retin diseas may exhibit serious complic caus sever visual impair owe lack awar retin diseas limit medic resourc understand artifici intellig ai use make predict perform relev analys activ area research retin diseas studi relev scienc citat index sci literatur ai retin diseas publish integr analyz | D005128;D012164 | T047 |
35,700,017 | prolifer fallopian tube fimbria cortic inclus cyst effect menstrual cycl levonorgestrel intrauterin contracept system object studi explor whether differ cell prolifer may help explain high grade serous ovarian cancer hgsoc aris fallopian tube fimbria ftf rather ovarian cortic inclus cyst cic ii compar premenopaus postmenopaus ftf prolifer reason age incid hgsoc increas slower rate menopaus iii compar ftf prolifer cycl women women use levonorgestrel intrauterin contracept system lng ius see whether prolifer lng ius lower | D003560;D007436 | T074;T190 |
35,700,016 | usabl issu evid base psychosoci intervent implement strategi cross project analysi peopl often prefer evid base psychosoci intervent ebpi mental health care howev intervent frequent remain unavail peopl nonspecialti integr set primari care school previous research suggest usabl concept human center design could support understand barrier facilit success adopt ebpi support redesign ebpi implement strategi | D001523;D000083626 | T061;T048 |
35,700,015 | condit growth defect bordetella pertussi bordetella bronchiseptica ferric uptak regul fur mutant outer membran vesicl omv promis tool develop novel vaccin respiratori pathogen bordetella pertussi bordetella bronchiseptica unfortun vesicul bordetella low cost effect vaccin product bacteria iron limit inactiv fur gene shown increas omv product presum downregul mla gene encod machineri mainten lipid asymmetri outer membran follow similar approach bordetella wherea fur mutant readili obtain b bronchiseptica b pertussi fur mutant could obtain iron deplet condit indic fur mutat condit lethal bacterium fur mutant display growth defect iron replet media presum constitut express iron uptak system result iron intox accord express escherichia coli ferritin ftna sequest intracellular accumul iron rescu growth mutant media fur mutat led constitut express novel vaccin candid tonb depend receptor faua siderophor alcaligin bhur heme howev neither inactiv fur growth iron limit improv vesicul presum express mla gene appear unaffect | D016950 | T007 |
35,700,013 | novel enolas antibodi target multipl interact player tumor microenviron advanc prostat cancer prostat cancer one common caus cancer death men worldwid treatment option limit patient advanc stage prostat cancer upon oncogen inflammatori stimul tumor cell immun cell express cell surfac enolas eno plasminogen receptor facilit migrat via plasmin activ littl known role eno prostat cancer especi tumor microenviron tme hypothes target surfac eno specif mab would exert multifactori therapeut potenti prostat cancer vivo show eno mab hul reduc growth subcutan pc xenograft monocyt recruit intratumor angiogenesi pc intratibi implant model hul reduc tumor growth osteoclast activ bone investig antitumor mechan eno mab found block surfac eno signific reduc vegf induc tube format endotheli cell vitro furthermor hul inhibit inflamm enhanc osteoclast activ secret invas relat cytokin ccl tgf osteoclast addit inflamm induc migrat chemotaxi androgen independ prostat cancer cell dose depend inhibit hul summari show eno mab target multipl tme nich involv prostat cancer progress bone metastasi via plasmin relat mechan may provid novel immunotherapi approach men advanc prostat cancer | D011471;D059016 | T191;T070 |
35,700,012 | use social media clinic research recommend exampl brown lifespan center digit health social media integr research increas american social media particip state would share data research yet potenti data transform health outcom fulli realiz way clinic research perform held back use technolog research depend investig awar potenti abil innov within regulatori institut guidelin brown lifespan center digit health launch initi address challeng provid help framework expand social media use clinic research | D061108 | T170 |
35,700,010 | refer adjust loss life expect popul base cancer patient surviv comparison applic colon cancer sweden loss life expect lle defin differ life expect patient cancer general popul use measur summar impact cancer diagnosi individu life expect howev less use make comparison cancer surviv across group time lle influenc mortal due cancer caus life expect general popul | D003110;D008017 | T191;T068;T081;T102 |
35,700,009 | ecolog analysi correl cervic cancer morbid mortal sub saharan africa cervic cancer fourth lead caus death among women worldwid burden fall low middl incom countri studi correl cervic cancer incid mortal case fatal sub saharan africa | D030361;D010412;D002583 | T191;T047 |
35,700,008 | investig activ site amino acid influenc carbon chlorin isotop fraction reduct dechlorin reduct dehalogenas rdase corrinoid depend enzym reduct dehalogen organohalid respiratori process compar isotop effect biotic catalyz reaction refer experi abiot corrinoid catalyst compound specif isotop analysi csia shown yield valuabl insight enzym mechan kinet includ rdase report isotop fraction biotransform chloroform cf carbon c chlorin cl correspond ccl valu result high suppress compar isotop effect observ cf biotransform anoth organ high similar rdase sequenc ident amino acid level observ abiot dehalogen cf amino acid differ occur four locat within two differ rdase activ site studi examin whether differ potenti affect observ c cl ccl structur protein model approxim locat residu elucid possibl control reaction mechan andor substrat bind effici four locat conserv among chloroalkan reduc rdase high amino acid similar suggest locat may import determin isotop fraction within homolog group rdase | D002244;D045728 | T121;T109;T196 |
35,700,001 | investig potenti molecular player therapeut drug molecul carfilzomib resist multipl myeloma comprehens bioinformat analysi multipl myeloma mm second common hematolog malign still remain beyond cure acquir drug resist proteasom inhibitor carfilzomib cfz therapi use one key therapi mm recent obstruct incid cfz resist under mechan acquir cfz resist mm littl understood therefor current studi aim investig differenti express gene deg associ micro rnas mirna transcript factor tfs microarray dataset cfz resist cfz sensit mm cell line obtain gene express omnibus geo databas deg detect use geor tool two dataset common deg identifi venn diagram gene ontolog go pathway enrich analysi perform david databas string databas cytoscap tool protein protein interact ppi network deg construct genet alter deg investig use cosmic databas interact network deg mirna well tfs obtain construct use mirdip trrust mirnet tool drug gene interact analysi perform identifi potenti drug molecul dgidb tool sever common deg identifi cfz resist mm pdgf vegf wnt signal pathway signific enrich might involv mm progress mirna analysi identifi hsa mir p hsa mir p target deg various drug molecul dabrafenib vemurafenib venetoclax could potenti attenu mm pathophysiolog detect entir studi might provid new understand cfz resist mm | D009101;D035683 | T191;T123;T114 |
35,699,988 | chromobacterium alticap sp nov chromobacterium sinusclupearum sp nov isol wild cranberri bog cape cod nation seashor usa two non pigment strain genus chromobacterium mwu mwu isol wild cranberri bog cape cod nation seashor usa isol character genom phenotyp analys result indic repres two novel speci base total genom sequenc closest relat chromobacterium amazonens group includ recent describ chromobacterium paludi whole genom sequenc compar genom blast distanc phylogeni digit dna dna hybrid averag nucleotid ident analys type strain nearest speci mwu mwu fell well accept cutoff valu speci related clear indic repres novel speci although littl known organ situ laboratori condit mwu produc modest amount hcn strong posit exoproteas activ wherea mwu produc hcn exoproteas predomin fatti acid isol sum c cis c cis isol produc siderophor pyomelanin pigment rich media neither haemolyt sheep blood agar propos name chromobacterium alticap sp nov type strain mwu atcc tsd ccos chromobacterium sinusclupearum sp nov type strain mwu atcc tsd ccos taxa | D002861;D029799 | T007;T168;T002 |
35,699,987 | constitut meaning improv myelodysplast syndrom myelodysplast syndrom mds heterogen spectrum clonal stem cell disord character ineffect hematopoiesi result peripher blood cytopenia clinic manifest disord vari rang mild asymptomat anemia mark truncat life expect underscor import risk adapt therapi mds therapi lower higher risk patient area immens therapeut opportun part due divers treatment goal patient defin constitut meaning benefit patient viewpoint correl metric hematolog improv respons rate develop novel therapi fals reassur physician patient specif intervent burdensom disconnect patient sens wellb correl improv qualiti life longev discuss align drug develop goal patient goal lead meaning improv mds clinic care | D009190;D015470;D013921;D000740 | T191;T047;T046 |
35,699,986 | identif mucilaginibact conchicola sp nov mucilaginibact achroorhodeus sp nov mucilaginibact pallidiroseus sp nov emend descript genus mucilaginibact three chitinolyt gram negat light pink capsul form rod shape bacteri strain glide motion mysh mja dk isol seashel soil foxtail respect phylogenet analysi rrna gene sequenc concaten align core gene indic strain mysh mja dk novel speci genus mucilaginibact exhibit high rrna sequenc similar ie among novel strain contain sum featur c c andor c iso c mk predomin fatti acid menaquinon accord cazi code gene kaa mysh mja interpret strain contain gh famili code gene except dk show gh famili gene strain like degrad chitin chitobios direct n acetyl glucosamin may enhanc chitinolyt capac thus make stain potenti use industri chitin degrad base distinct morpholog physiolog chemotaxonom phylogenet differ closest phylogenet neighbour propos strain mysh mja dk repres three novel speci genus mucilaginibact name mucilaginibact conchicola sp nov kacc jcm mucilaginibact achroorhodeus sp nov kacc nbrc mucilaginibact pallidiroseus sp nov kacc nbrc propos emend descript genus mucilaginibact propos | D005227;D012988 | T109;T123;T067;T168 |
35,699,984 | evalu web base health inform perspect women eat disord themat analysi user experi eat disord use internet sourc inform whether prorecoveri activ web base treatment look inform support share activ promot eat disord behavior desir lifestyl choic pro eat disord communiti read creat pro eat disord post assess web base eat disord relat inform crucial understand context ill health profession web base intervent | D001068 | T047;T048 |
35,699,983 | impact model reduc medicar account care organ payment hospit event high need high cost patient longitudin cohort studi impact model promis help solv nationwid crisi care high need high cost patient match specif case manag program patient use benefit impact score limit tailor model specif program popul | D060866 | T093 |
35,699,982 | technolog base compens assess detect upper extrem activ stroke survivor systemat review upper extrem ue impair affect stroke survivor account rehabilit discharg hospit releas compens common use stroke survivor ue rehabilit appli adapt loss motor function may imped rehabilit process long term lead new orthoped problem intens monitor compensatori movement critic improv function outcom rehabilit | D020521;D000071939 | T061;T047 |
35,699,981 | agriterribact soli sp nov isol herbicid contamin soil gram stain negat non spore form rod shape bacterium design strain ns isol herbicid contamin soil sampl nanj pr china taxonom status investig polyphas approach cell growth strain ns occur c optimum c ph optimum ph presenc wv nacl optimum without addit nacl rrna gene sequenc strain ns show high similar agriterribact humi yj similar follow terrimona terra tr terrimona pekingensi qh averag nucleotid ident averag amino acid ident digit dna dna hybrid valu draft genom strain ns humi yj respect respiratori quinon mk phosphatidylethanolamin unidentifi lipid major polar lipid major cellular fatti acid strain ns contain high amount iso c iso c oh iso c g sum featur c c andor c c gc content total dna determin mol morpholog physiolog chemotaxonom phylogenet analys clear distinguish strain closest phylogenet neighbour thus strain ns repres novel speci genus agriterribact name agriterribact soli sp nov propos type strain ns cctcc ab kctc | D020563;D006540 | T007;T131 |
35,699,979 | nanoarchitectur graphen organ framework drug deliveri chemo phototherm synergist therapi combin phototherapi chemotherapi receiv extens attent field cancer therapi henc graphen organ framework gof larg space prepar solvotherm method novel nanocomposit base bovin serum albumin bsa anticanc drug doxorubicin dox develop effect achiev phototherm chemotherapi synergist treatment feed ratio dox load capac gof bsadox nanocomposit possess unobvi ph respons characterist well cumul releas dox reach c acid environ ph nanocarri also show excel phototherm properti phototherm stabil vitro addit nm near infrar laser nir irradi gof bsadox nanocomposit generat larg amount heat signific enhanc synergist antitumor effect vitro phototherm chemotherapi furthermor gof bsadox nanocomposit exhibit signific increas cytotox nir compar chemotherapi phototherm therapi alon suggest combin chemotherapi phototherm therapi excel antitumor capac therefor porous gof nanocarri may great potenti combin anti tumour therapi | D000970;D006108;D006979;D053758 | T073;T061;T121;T109;T196 |
35,699,975 | risk factor develop orthostat hypotens autolog stem cell transplant patient multipl myeloma orthostat hypotens oh well recogn phenomenon occur multipl myeloma mm patient undergo autolog stem cell transplant asct associ signific morbid mortal retrospect analysi patient admit first asct june april found patient diagnos oh cours asct includ patient found oh day first orthostat vital check exclud patient patient develop oh peri transplant period median day post asct ci oh signific impact length hospit progress free overal surviv multivari analysi reveal four risk factor ie weight lossday white race gabapentin antihypertens two protect factor ie antihistamin proton pump inhibitor associ develop peri transplant oh | D018380;D007024;D009101 | T191;T061;T047 |
35,699,971 | differ spectrum steroidogen enzym inhibit osilodrostat metyrapon acth depend cush syndrom patient osilodrostat new hydroxylas inhibitor mode action analog metyrapon object studi compar steroidogen profil patient treat either osilodrostat metyrapon adrenocorticotroph hormon acth depend cush syndrom cs | D003480;D007093;D008797;D011725 | T047;T121;T109;T130;T125 |
35,699,970 | nk cell lymphoma nasal caviti paranas sinus denmark nationwid cohort studi compar asian latin american popul sinonas nk cell lymphoma rare europ patient sinonas nk cell lymphoma denmark valid histolog diseas behavior demograph extract medic record nation registri prognost factor associ mortal determin use surviv statist includ patient extranod nkt cell lymphoma nasal type enktcl peripher cell lymphoma otherwis specifi ptcl median age patient male enktcl ptcl year overal surviv respect progress free surviv enktcl stage perform status increas mortal signific hr p hr p conclus dissemin diseas dismal outcom onset enktcl ethnic homogen european cohort decad later report asian popul | D054391;D010256 | T191;T023;T030 |
35,699,968 | tale topoisomeras knotti genet materi backdrop plasmodium biolog untangl overwind genet materi inevit part dna replic repair recombin transcript topoisomeras belong conserv enzym famili amend dna topolog various process dna metabol relax genet materi topoisomeras transient break phosphodiest bond one dna strand remain associ cleavag site form coval enzym dna intermedi releas torsion stress allow broken dna ligat enzym biolog function topoisomeras rang separ sister chromatid follow dna replic aid chromosom condens segreg mitosi topoisomeras also activ involv meiotic recombin unicellular apicomplexan parasit plasmodium falciparum harbor differ topoisomeras subtyp substanti differ sequenc function human counterpart review highlight biolog function identifi plasmodium topoisomeras along compar analysi ortholog human model organ also focus recent advanc toward develop topoisomeras chemic inhibitor underscor druggabl uniqu topoisomeras subunit absent human plasmodium harbor three distinct genom nucleus apicoplast mitochondria respect undergo non canon cell divis schizont stage develop review emphas specif development stage plasmodium futur topoisomeras research focus | D004264;D010961 | T204;T126;T116;T028 |
35,699,967 | post transplant cyclophosphamid pharmacokinet haploident hematopoiet cell transplant outcom exploratori studi pharmacokinet cyclophosphamid explor optim condit dose hypothes post transplant cyclophosphamid ptci metabolit carboxi ethyl phosphoramid mustard cepm pharmacokinet might impact haploident transplant haplo hct outcom cepm area curv auc determin eleven sampl timepoint day use lc msms median cepm auc cohort patient mghrl incid sever chronic graft versus host diseas gvhd vs p gvhd relaps free surviv grfs signific inferior cepm auc mghrl group day vs day p howev differ grade iii iv acut gvhd vs p overal surviv day vs reach p cepm auc associ sever chronic gvhd grfs post haplo hct exploratori studi scope person day ptci dose base day cepm auc | D006086;D018380 | T061;T047 |
35,699,966 | solv coagul conundrum compar prophylaxi strategi adult patient receiv peg asparaginas peg asparaginas key compon treatment regimen acut lymphoblast leukemia major side effect includ thrombosi bleed howev current consensus method prevent complic multi center retrospect cohort studi adult compar two prophylaxi strategi cryoprecipit fresh frozen plasma cryoffp versus cryoprecipit antithrombin atiii overal incid venous thromboembol vte signific differ two group cryoffp cryoatiii p neither grade bleed cryoffp cryoatiii p given signific cost associ atiii without clear benefit care benefit risk analysi consid util atiii prophylaxi strategi prevent thrombosi bleed follow asparaginas administr | D001215;D013927 | T121;T046;T126;T116 |
35,699,965 | loss function flnc variant associ arrhythmogen cardiomyopathi phenotyp identifi exom sequenc general clinic popul flnc gene recent garner attent like caus arrhythmogen cardiomyopathi consid action genet condit howev associ diseas unselect clinic popul unknown hypothes individu loss function variant flnc flnc lof would increas odd arrhythmogen cardiomyopathi associ phenotyp versus variant negat control geising mycod cohort | D002311;D064448 | T047;T123;T116 |
35,699,964 | swellabl sorbent coat parallel extract storag analysi plant metabolit quantit qualit measur trace level analyt plant foodstuff eg secondari metabolit like carotenoid often perform central core facil site laboratori howev prepar storag andor transport intact sampl sampl extract may cumbersom complic especi air sensit analyt describ develop inexpens swellabl microextract sweme devic extract storag nonpolar analyt sweme devic consist thin layer poli dimethylsiloxan pdms graft onto stainless steel support pretreat sweme devic small volum organ solvent caus pdms swell swollen sweme devic immers direct complex matric absorpt extract low molecular weight nonpolar analyt follow storag analyt solvent desorb prior character proof principl work carotenoid tomato carrot demonstr sweme appropri semiquantit analys increas stabil air sensit analyt storag ambient temperatur compar solvent extract carotenoid profil fraction carotenoid contribut tomato carrot sampl well correl sweme liquid liquid extract r lycopen abund carotenoid tomato saw less decreas extract mass month ambient sweme storag extract desorpt run parallel use multiwel plate summari swell sorbent extract sweme devic conveni inexpens approach isol storag analyt complex matric may particular well suit evalu larg number plant sampl extern laboratori | D002338;D059625 | T121;T059;T109;T123 |
35,699,959 | efficaci mobil instant messag deliv brief motiv interview parent promot physic activ pediatr cancer survivor random clinic trial physic activ benefici effect mitig cancer treatment relat late effect howev children surviv cancer often physic inact brief motiv interview may effect approach increas children physic activ level | D000073116;D062405;D009369 | T191;T101;T061;T201 |
35,699,958 | associ medicaid expans emerg depart visit medic urgenc relat littl known associ medicaid elig expans patient protect afford care act emerg depart ed visit categor medic urgenc | D008484;D058991 | T064;T089 |
35,699,957 | associ obes physic activ screen state level trend racial ethnic dispar breast cancer incid mortal us breast cancer caus disproportion diseas burden among various racial ethnic group us howev state level tempor trend racial ethnic dispar whether metabol lifestyl factor screen access associ tempor chang remain larg unknown | D001943;D005006 | T191;T098;T102 |
35,699,956 | sex differ risk first recurr ventricular tachyarrhythmia among patient receiv implant cardiovert defibril primari prevent current guidelin primari implant cardiovert defibril icd therapi account sex differ arrhythm risk icd candid | D017147;D017180 | T046;T047;T074 |
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