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biomedical-topic-categorization-validation

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analysi thromboembol thrombocytopen event azd bntb mrna covid vaccin nordic countri vaccin paramount halt covid pandem safeti data essenti determin risk benefit ratio covid vaccin

D000086382;D000086663;D002561;D003324;D013921;D020246

T047;T046;T200;T067

trend health care use among black white person us us black peopl receiv less health care white peopl data long term trend dispar provid histor context interpret contemporari inequ lack

D044383;D006278

T098;T064;T089

avpcancerfre impact digit behavior chang intervent parent hpv vaccin relat percept behavior parent hesit contribut reduc hpv vaccin rate hpvcancerfre app hpvcf design assist parent make evid base decis regard hpv vaccin studi examin parent vaccin elig youth yrs use hpvcf addit usual care demonstr signific posit intent attitud toward hpv vaccin greater hpv vaccin rate compar use hpvcf clinic n within larg urban pediatr network random assign treatment hpvcf usual care comparison usual care condit rct conduct septemb februari parent complet baselin month follow survey particip level analysi determin chang hpv vaccin initi behavior relat psychosoci determin predictor hpv vaccin initi parent n complet baselin month follow survey femal yrs marri employ colleg educ privat insur group analysi hpvcf efficaci demonstr parent assign receiv hpvcf signific increas knowledg hpv hpv vaccin p parent access content within hpvcf signific increas knowledg hpv hpv vaccin p perceiv effect hpv vaccin p chang hpv vaccin initi signific multivari model describ predictor hpv vaccin initi demonstr associ tdap mcv vaccin adopt posit chang perceiv effect hpv vaccin reduct perceiv barrier hpv vaccin hpvcf appear feasibl adjunct educ receiv usual care visit reinforc valu app support import persuas voic health care provid overcom parent hpv vaccin hesit

D030361;D053918

T121;T047;T116;T129

automat learn hydrogen bond fix amber rna forc field capabl current forc field reproduc rna structur dynam limit sever method develop take advantag experiment data order enforc agreement experi extend exist framework allow arbitrarili chosen forc field correct term fit quantif discrep observ back calcul simul correspond experi appli robust regular protocol avoid overfit addit introduc compar number differ regular strategi name l l kish size relat kish size relat entropi penalti train set includ gacc tetram well challeng system name gcgagagc gcuucggc rna tetraloop specif intramolecular hydrogen bond amber rna forc field correct automat determin paramet call ghbfix opt valid involv separ simul system present train set gcuucggc new system seen train caau uuuu tetram display improv regard nativ popul tetraloop well good agreement nmr experi tetram use new paramet simul fold rnas kink turn l stalk rrna includ hydrogen bond type suffici present train set allow final modif paramet set name ghbfix suggest applic wider rang rna system

D056004;D012313

T044;T066;T114

resuscit order end life treatment cohort deceas norwegian univers hospit resuscit dnr order impli cardiopulmonari resuscit start absent delay dnr order advanc chronic diseas may indic suboptim communic diseas stage prognosi treatment goal studi object determin clinic practic patient involv regard dnr preval life prolong treatment last week life

D009369;D016414

T191;T058;T170

brain structur among middl age older adult long stand type diabet dcctedic studi individu type diabet mellitus tdm live age neuropatholog chang increas evid hypothes middl age older adult long stand tdm show abnorm brain structur comparison control subject without diabet

D048909;D003922

T047

focus acoust vortex regul composit nanodroplet combin checkpoint blockad high perform tumor synergist therapi combin checkpoint blockad focus ultrasound fus physic therapi enhanc antitumor immun respons improv precis effici immunotherapi howev one major disadvantag convent fus treatment small lesion size prolong treatment durat construct focus acoust vortex fav system hollow cylindr focal region exhibit larger focal region compar convent fus frequenc develop one synergist therapi metastat breast cancer base integr fav doubl combin sequenc regul phase transform nanodroplet cpda pfh checkpoint blockad immunotherapi singl treatment fav cpda pfh result fold higher inhibit tumor growth compar fus cpda pfh addit fav regul cpda pfh combin icb induc system immun respons inhibit growth primari inhibit rate distal tumor also reduc progress lung metastasi addit synergist therapi achiev long term immun memori effect prevent tumor growth improv surviv time mice long term surviv rate tumor bear mice treat fav cpda pfh anti pd l day treatment studi proof concept cascad amplifi synergist tumor therapeut base ultrason hyperthermia cavit sonodynam therapi sdt checkpoint blockad immunotherapi fav regul cpda pfh phase transform nanodroplet

D006979;D009369

T191;T061

high titer product fungal anhydrotetracyclin tan engin yeast antibiot resist grow global health threat demand urgent respons tetracyclin wide use antibiot class increas succumb antibiot resist generat novel analogu therefor top prioriti public health fungal tetracyclin provid structur enzymat divers novel tetracyclin analogu product tractabl heterolog host like yeast combat antibiot resist pathogen success engin saccharomyc cerevisia baker yeast saccharomyc boulardii probiot yeast produc nonantibiot fungal anhydrotetracyclin tan synthet defin medianecessari clean purificationsthrough heterolog express tan gene mine fungus aspergillus niger atcc accomplish via promot librari base combinatori pathway optim biosynthet tan gene coexpress putat tan efflux pump reduc tan toxic yeast simultan increas supernat titer ii develop medium throughput uv visibl spectrophotometr assay facilit tan combinatori librari screen multiprong approach optim tan product yield fold increas compar previous report cerevisia yield tan import tetracyclin analogu precursor thus present first step toward generat novel tetracyclin analogu therapeut combat current emerg antibiot resist also report first heterolog product fungal polyketid like tan probiot boulardii highlight engin boulardii biosynthes complex natur product like tetracyclin set stage equip probiot yeast synthet therapeut function generat live therapeut biocontrol agent clinic agricultur applic

D012441;D014216

T121;T109;T004;T130

context depend effect il rewir immun distinct cellular circuit interleukin il key homeostat cytokin therapeut applic immunogen tolerogen immun modul clinic use hamper pleiotrop function widespread receptor express unexpect advers event develop novel mous strain divert il product allow identif contextu outcom network analysi identifi prioriti access treg competit fit cost il product among treg convent cd cell cd nk cell contrast exhibit prefer autocrin il product il sourc dendrit cell amplifi treg wherea il produc b cell induc two context depend circuit dramat expans cd treg ilc cell latter drive downstream il mediat eosinophil circuit sourc specif effect demonstr contextu influenc il function potenti explain advers effect observ clinic trial target il product therefor potenti amplifi quench particular circuit il network base clinic desir

D007376;D007694;D050378

T121;T025;T116;T129

outcom implant place retain craniofaci prosthes retrospect cohort studi follow year retrospect assess treatment outcom endoss implant place retain craniofaci prosthes

D015921;D020273

T074

stack depend vibron coupl drive excit state dynam perylenediimid assembl vibron coupl interplay electron nuclear vibrat motion consid critic mechan photoinduc reaction energi transfer charg transfer singlet fission howev understand particular vibron coupl impact excit state dynam lack due limit number experiment studi model molecular system herein use two dimension electron spectroscopi des launch interrog rang vibron coher two distinct type perylenediimid slip stacksalong short long molecular axe form either excim mix state frenkel exciton fe charg transfer state explor function vibron coher use quantum beatmap display fourier amplitud signal oscil function pump probe frequenc along knowledg characterist signatur fe ionic excim speci find low frequenc vibrat mode short axi slip stack appear concomit format excim state surviv fold longer fe state refer monom show phase shift compar mode long axi slip stack pair low frequenc mode coupl high frequenc coordin fe state found play critic role mix state generat find thus experiment reveal complex vari role vibron coupl tight pack multim undergo rang photoinduc process

D014732

T070

vertic orient zinc oxid nanorod base electrolyt gate field effect transistor high perform glucos sens nanomateri base biosensor promis fit portabl field deploy diagnosi sensor devic due mass product miniatur integr capabl howev fabric high stabl reproduc biosensor devic challeng work grow vertic orient architectur zinc oxid nanorod onto activ work area ie channel sourc drain field effect transistor fet use low temperatur hydrotherm method glucos oxidas enzym immobil zinc oxid nanorod surfac physic adsorpt method fabric electrolyt gate fet base glucos biosensor electr properti electrolyt gate fet biosensor measur differ glucos concentr found linear increas current mm glucos concentr high sensit ammcm low detect limit mm illustr high reproduc fabric process zinc oxid nanorod base fet vertic grown nanorod higher surfac volum ratio enhanc enzym immobil provid microenviron longer enzym activ translat better glucos sens paramet addit electrolyt gate fet biosensor show promis applic fresh drawn mous blood sampl find suggest great opportun translat practic high perform biosensor broad rang analyt

D015374;D043942;D015034

T073;T059;T121;T075;T197

cardioren complic young onset type diabet compar white american african american explor risk associ mediat effect develop chronic kidney diseas ckd heart failur hf young usual onset type diabet td white american african american aa

D003924;D006333;D051436

T047;T046

synthesi ketoamid via gold carben intermedi ketoamid found import function group broad spectrum inhibitor corona virus virus report unpreced gold catalyz fold reaction bromoalkyn anthranil hydrolysi initi product direct lead ketoamid water addit intermedi iminoimidoyl halid deliv ketoamid broad rang bromoalkyn

D006046;D008697

T121;T109;T196

symmetri driven total synthesi myrioneurinol report total synthesi myrioneuron alkaloid myrioneurinol enabl recognit hidden symmetri within polycycl structur approach trace myrioneurinol complex framework back symmetr diketon precursor doubl reduct amin forg central piperidin unit employ inexpens chiral amin key desymmetr event four stereocent natur product includ core quaternari stereocent set absolut sens provid first asymmetr entri target noteworthi strateg maneuv includ util bicycl alken latent cis bis hydroxymethyl synthon topolog control alken hydrogen overal synthesi proceed step yield commerci materi

D000470;D006576

T121;T131;T109;T123

cct newli identifi aggrephagi receptor mammal specif mediat autophag clearanc solid protein aggreg protein aggreg strong correl pathogenesi multipl human patholog repres neurodegen diseas one type select autophagi known aggrephagi select degrad protein aggreg recent studi ge lab report tric subunit cct chaperonin contain tcp subunit first identifi specif aggrephagi receptor mammal switch cct role chaperonin specif aggrephagi receptor achiev cct monom format cct function independ ubiquitin tric complex facilit autophag clearanc solid protein aggreg studi provid intrigu possibl cct specif aggrephagi receptor might import target treatment various diseas associ protein aggreg

D019636;D066329

T047;T116

first bopyrid isopod hydrotherm vent pleurocryptella shinkai sp nov isopoda epicaridea parasit shinkaia crosnieri decapoda anomura deep sea hydrotherm vent extrem environ harbor divers anim communiti power chemosynthesi though vent endem macrofauna center interest sinc discoveri macroparasit receiv littl attent report bopyrid epicaridean isopod infest symbiot munidopsid squat lobster shinkaia crosnieri baba william three vent field okinawa trough describ pleurocryptella shinkai sp nov although morpholog close congen pleurocryptella formosa bonnier pleurocryptella wolffi bourdon pleurocryptella altali william boyko marin femal via bodi proport charact barbula antenna pleopod pleomer male via featur head pleomer uropod new speci exhibit distinct charact phylogenet reconstruct base rrna gene bp insuffici resolv clarifi relationship differ epicaridean lineag exact posit p shinkai sp nov recov p shinkai sp nov distant posit type genus pseudionina indic non monophyli subfamili crustacean success vent second vent epicaridean report thermaloniscus cotylophorus bourdon east pacif rise describ singl cryptoniscus larva first report vent bopyrid isopod first vent epicaridean known host epicaridean lineag adapt toler condit hydrotherm vent futur research like uncov epicaridean interest parasit extrem habitat

D033381;D033364;D060086;D033321;D011077

T070;T204

zygot nano mutant medaka oryzia latip display gradual loss germ cell precoci spermatogenesi gonad develop nano one compon germ plasm evolutionarili conserv fli mammal medaka oryzia latip matern provid nano essenti mainten primordi germ cell pgcs generat nano loss function mutant use transcript activ like effector nucleas talen examin function zygot nano medaka zygot nano homozyg mutant deriv nano heterozyg mother form germ cell howev hatch number germ cell decreas consider result infertil nano femal male surpris nano xx xy mutant underw precoci spermatogenesi earli gonad develop seen loss function mutant foxl germlin sex determin gene medaka therefor addit mainten germ cell result suggest zygot nano affect proper regul germlin sex xx medaka

D009990

T013

transcriptom analysi reveal altern splice chang immun relat gene giant panda ailuropoda melanoleuca respons canin distemp vaccin canin distemp virus cdv high fatal virus giant panda ailuropoda melanoleuca although vaccin key prevent measur captiv giant panda immun respons giant panda vaccin remain unclear therefor studi focus differenti altern splice das event giant panda vaccin investig role altern splice immun respons giant panda cdv vaccin studi identifi das gene das event kegg function enrich analysi das gene show enrich dna damag repair immun relat pathway combin analysi das differenti express gene previous research identifi differenti express gene das event found import immun relat gene il il ilrap chuk ifi cd cd underw das event involv immun respons giant panda cdv vaccin describ altern splice event giant panda cdv vaccin first time show result indic altern splice import role regul immun respons giant panda vaccin

D004216;D004217;D004283;D001503;D014612

T047;T116;T121;T129;T015;T005

observ predat paranthura japonica richardson isopoda cymothoida paranthurida although isopod anthuroidea predat littl inform predatori behavior studi investig predat paranthurid paranthura japonica origin describ northern japan recent report invas alien speci western america europ six crustacean speci two isopod two amphipod two tanaidacean one co occur p japonica wild one pycnogonid speci use prey candid experi paranthura japonica prey candid speci except pycnogonid grasp falciform pereopod insert pierc type mouthpart suck intern content prey cannib scaveng observ sever p japonica individu put singl aquarium studi show p japonica aggress predat consum various crustacean includ one never encount wild result suggest p japonica high impact alien ecosystem invad predat nativ crustacean cytochrom c oxidas subunit coi nucleotid sequenc putat p japonica oshoro japan topotyp individu muroran confirm popul dealt p japonica

D033304;D033321

T204

sea habitat use rhinocero auklet breed shelf region eastern hokkaido sea habitat use breed seabird strong influenc marin environment featur vari space time use bio logger allow research track fine scale movement seabird provid opportun identifi primari factor affect area use forag use gps logger track chick rear rhinocero auklet cerorhinca monocerata wing propel diver daikoku island eastern hokkaido japan central phase forag activ bird trip determin use multipl chang point model examin environment factor explain distribut forag phase general addit model use sea surfac temperatur chlorophyl concentr bathymetri distanc coloni explanatori variabl obtain inform support behavior track prey item bill load adult auklet collect found auklet forag continent shelf shallow isobath distanc coloni relat area use adult auklet predomin brought back age chum salmon oncorhynchus keta abund coastal water along southeast hokkaido studi period find indic rhinocero auklet rear chick henc visit nest frequent daikoku island find suitabl feed ground nearbi

D046091;D017753

T012;T082;T070

manual curat gene model set ascidian ciona robusta ciona intestinali type genetranscript model set predict decod genom sequenc import resourc wide rang biolog studi accuraci gene model therefor critic deduc accur conclus comput predict model sometim inconsist experiment data cdna clone rna sequenc ascidian ciona robusta ciona intestinali type manual curat genetranscript model set construct use assembl decod sequenc associ chromosom use last decad recent new genom assembl publish decod sequenc associ chromosom present studi provid high qualiti version genetranscript model set latest assembl ciona genom use varieti studi development biolog studi evolutionari studi physiolog studi current genetranscript model set provid fundament biolog resourc

D002938

T204

current genet status nagaremon charr threaten morphotyp salvelinus leucomaeni ane river lake biwa system central japan comment conserv stream dwell white spot charr salvelinus leucomaeni popul tend uniqu color spot pattern differ region may even display stream specif pattern extrem edg divers found individu atyp bodi color pattern call nagaremon type charr rare morphotyp salvelinus leucomaeni hereaft term nagaremon charr sympatr occur normal charr report six small isol popul japan base morpholog ecolog perspect nagaremon charr consid intraspecif color variant white spot charr although genet status nagaremon charr determin studi genet divers popul structur nagaremon charr tributari ane river lake biwa system investig microsatellit mtdna analys nagaremon charr sympatr normal charr tributari share mtdna haplotyp assign cluster structur analysi discrimin analysi princip compon dapc result suggest nagaremon charr ane river intra popul specif color variant white spot charr waterfal nagaremon charr specimen exhibit extrem reduc genet divers indic genet drift may account fixat nagaremon morphotyp normal charr waterfal cluster separ hatcheri rear charr indic nativ status former thus nagaremon charr normal charr entir ane river tributari conserv

D060106;D014337

T083;T013;T070

mitochondri phosphatas ptpmt requir proper growth rate red flour beetl tribolium castaneum protein tyrosin phosphatas mitochondri ptpmt mitochondri phosphatas high conserv anim function analys use knockout anim reveal varieti physiolog role ptpmt vertebr insect howev high lethal knockout anim role ptpmt later postembryon develop remain relat obscur present studi use rna interfer techniqu analyz ptpmt function later larval stage red flour beetl tribolium castaneum ptpmt express anterior posterior part bodi constitut without obvious fluctuat middl larval instar pupat ptpmt knockdown larva inject ptpmt doubl strand rna middl instar show prolong larval period main caus extra larval molt hand increas adult bodi length subtl ptpmt knockdown castaneum head capsul width smaller control anim larval instar express level gene encod mitochondri genom reduc ptpmt knockdown larva indic ptpmt play import role mitochondri function castaneum like speci contrast express level juvenil hormon jh biosynthet gene jh signal gene rather increas ptpmt knockdown larva may caus indirect reduct larval growth rate altogeth find indic ptpmt requir proper growth rate via mitochondri physiolog role castaneum larva

D001517;D014231

T204

phylogenet separ holotrichia speci insecta coleoptera scarabaeida exhibit circadian rhythm circabidian rhythm uniqu two day rhythm circabidian rhythm report black chafer holotrichia parallela howev remain unknown wide circabidian rhythm appear relat speci examin activ rhythm phylogeni congener speci inhabit japan investig appear circabidian rhythm subgenera genus holotrichia found holotrichia picea also exhibit circabidian rhythm addit regular circabidian pattern circabidian rhythm day switch circadian activ compon also observ day switch pattern h picea switch appear odd even day vice versa circadian like activ pattern major night activ minor dusk activ appear altern holotrichia kiotonensi holotrichia convexopyga holotrichia loochooana loochooana exhibit circadian rhythm two distinct clade b recogn histon h cytochrom c oxidas subunit ribosom rna phylogenet tree phylogenet separ accord subgener classif base extern morpholog previous studi behavior rhythm present studi clade includ nigrotrichia group member h kiotonensi h convexopyga h loochooana loochooana h loochooana okinawana clade b includ pedinotrichia group member h paralella h picea suggest separ nigrotrichia pedinotrichia behavior trait circabidian rhythm probabl appear ancestr speci pedinotrichia group includ h parallela h picea

D001517

T204

equat base anthropometr measur adipos tissu bodi fat bodi densiti predict children adolesc scope review assess bodi composit children adolesc import monitor health status anthropometr measur feasibl less expens techniqu bodi composit assess studi aim systemat map anthropometr equat predict adipos tissu bodi fat densiti children adolesc analyz methodolog aspect develop anthropometr equat use skinfold

D000273;D001823

T032;T024;T201

train militari psychiatrist adapt overcom covid highlight uniqu flexibl militari psychiatri train fleet born necess militari medicin continu find forefront medic innov generat militari physician never previous challeng continu provid top notch medic support servicememb varieti oper set midst global pandem militari medicin alway abl uniqu meet educ goal resid train covid brought new challeng forefront

D000086382;D008889;D008890;D011570

T091;T047;T097;T067

dabigatran etexil review pediatr venous thromboembol although rare children venous thromboembol vte mark like hospit patient particular use central venous access devic dabigatran etexil pradaxa one first direct non vitamin k antagonist oral anticoagul doac approv use pediatr patient approv eu usa treatment vte patient treat parenter anticoagul day prevent recurr vte open label phase b clinic trial pediatr patient acut vte treat month dabigatran etexil non inferior standard care soc treatment primari composit endpoint complet thrombus resolut freedom recurr vte vte relat death singl arm phase safeti studi patient experienc recurr vte month anticoagul dabigatran etexil dabigatran etexil general well toler studi bleed event most minor phase b studi occur similar incid soc although data use dabigatran etexil valuabl conveni treatment option pediatr vte

D000069604;D054556

T121;T047;T109

review popul pharmacokinet analys linezolid recent year mani studi popul pharmacokinet linezolid conduct comprehens review aim summar popul pharmacokinet model linezolid focus dosag optim maxim probabl attain certain pharmacokinet pharmacodynam paramet special popul search pubm embas databas popul pharmacokinet analys linezolid use parametr non linear mix effect approach includ observ prospect trial studi perform adult four children one adult children high subject variabl determin major model line variabl linezolid concentr previous detect observ studi studi found patient renal impair hepat failur advanc age low bodi weight higher exposur advers reaction rate contrast lower concentr therapeut failur associ obes patient young patient patient undergon renal replac techniqu critic ill patient inter individu intra individu variabl even greater suggest popul even higher risk underexposur overexposur therapeut drug monitor may warrant larg proport patient given mont carlo simul demonstr one size fit label dose mg everi h could lead toxic therapeut failur high valu minimum inhibitori concentr target pathogen research covari includ renal function hepat function drug drug interact relat p glycoprotein could help explain variabl improv linezolid dose regimen

D000900;D016638

T121;T047;T195

repositori describ anatom physiolog biolog chang obes popul inform physiolog base pharmacokinet model obes associ physiolog chang affect drug pharmacokinet obes individu underrepres clinic trial lead lack evid base dose recommend mani drug physiolog base pharmacokinet pbpk model overcom limit necessit detail descript popul characterist investig

D008954;D009765

T047;T075

phenytoin metabol ratio marker cypc activ superior cypc genotyp predictor warfarin clearanc cypc member cytochrom p cyp superfamili respons metabol drug undergo oxid metabol activ cypc exhibit mark inter individu variabl translat promin differ pharmacokinet cypc substrat character narrow therapeut window genet polymorph gene encod cypc account fraction variabl cypc activ phenytoin metabol ratio pmr marker cypc activ vivo correl cypc genet polymorph

D065729;D014859

T116;T131;T121;T109;T126

cellular immunophenotyp major spine surgeri adult asd reconstruct major steril traumat insult like caus perturb immun system immun respons surgeri associ outcom purpos studi examin detect immun signatur associ asd surgeri

D061026;D006684

T192;T116;T129

design analysi studi base hierarch composit endpoint insight dare trial dare nct random trial studi effect dapagliflozin sglt inhibitor hospit patient covid pneumonia cardiometabol risk factor conduct dare offer opportun defin innov clinic meaning endpoint new diseas would best reflect known profil dapagliflozin accompani statist challeng analysi interpret novel endpoint

D000086382;D016032

T047;T062;T170;T067

scratch tte languag switch idiom evid eye movement measur read idiom semant non composit multiword unit whose mean often go beyond liter interpret compon word eg break ice kick bucket spill bean accord hybrid model idiom process idiom subject direct retriev lexicon earli stage process word word composit reanalysi later stage comprehens howev less clear aspect disrupt idiom canon form thus direct retriev impact time cours comprehens eye track read studi healthi english french bilingu adult english domin languag read sentenc contain english idiom canon form eg break ice switch form phrase final noun translat french eg break glace thus within manipul momentari languag switch modifi canon form idiom time minim alter semant compon word thus nudg reader toward composit process rout analys eye movement data reveal switch cost longer read time earli late process stage idiom compar match liter phrase interest cost languag switch attenu avail translate equival idiom non target languag french eg briser la glace taken togeth result suggest direct retriev preferenti rout comprehens idiom canon form act effect repair strategi languag process system recov under form modifi idiom

D032882;D005133;D007802

T039;T041;T080;T171

systemat review religios relationship suicid suicid relat stigma formal mental health servic util among black american rate suicid increas among black american suicid rd lead caus death black american age th lead caus death black american age due increas need communiti mark increas literatur focus suicid black communiti publish sinc build better understand current state literatur suicid among black american offer suggest area research systemat review conduct spiritu religi belief often import cultur focus black communiti religi belief pose potenti unintend regard sanctiti life among black american focus systemat review religios effect suicid among black american religios found protect effect suicid among black american discourag formal mental health servic util systemat review also reveal dearth research relationship religios suicid relat stigma area research mention religi institut mental health intervent center encourag

D008605;D013405

T058;T033

clinic consider use sglt inhibitor therapi patient heart failur reduc eject fraction review heart failur hf continu increas preval repres signific burden healthcar system usa despit sever establish hf therapi particular hf reduc eject fraction hfref rate hf hospit cardiovascular cv mortal remain high type diabet td import risk factor hf two condit often occur concurr sever cv outcom trial shown sodium glucos cotransport inhibitor sglti class antihyperglycem drug reduc risk hf relat outcom patient td either establish cv diseas multipl cv risk factor subsequ larg clinic studi investig effect sgltis patient hfref without td shown dapagliflozin empagliflozin signific reduct hospit hf cv mortal data led us food drug administr approv dapagliflozin empagliflozin novel treatment pathway patient hfref empagliflozin subsequ approv treatment hf regardless eject fraction clinic practic algorithm assist cardiologist identifi patient may elig sglti treatment well appropri timefram initi therapi paramet patient monitor given evid sgltis benefici manag hf specif hfref irrespect under td evid base recommend greater clinician familiar facilit integr sgltis general hf therapeut manag

D003924;D006333;D000077203

T121;T047;T046;T109

restless sleep disord rsd new sleep disord children rapid review restless sleep disord rsd recent identifi pediatr sleep disord character frequent movement sleep associ daytim symptom review summar expand evid clinic present rsd potenti pathophysiolog associ comorbid current treatment option help pediatrician identifi children rsd time manner

D012148;D012893

T047;T048

neurolog complic malaria discuss neurolog complic pathophysiolog organ damag follow malaria infect

D001929;D000086382;D016779;D016778;D054038

T047;T046;T067

histori diagnosi treatment ms brief overview overview histori diagnosi treatment multipl sclerosi serv introduct rich histori multipl sclerosi show continuum increment advanc date back centuri

D009103;D009462

T047;T091

analysi character lactobacillus paragasseri lacticaseibacillus paracasei two probiot bacteria degrad intestin oxal hyperoxalur rat present studi character probiot properti two commerci avail bacteri strain lactobacillus paragasseri ublg lacticaseibacillus paracasei ublpc evalu abil degrad oxal vitro hyperoxaluria induc nephrolithiasi rat model ublg harbor two oxal catabol gene oxalyl coenzym decarboxylas oxc formyl coenzym transferas frc previous shown degrad oxal vitro effect show ublpc lack oxc frc could still degrad oxal vitro strain harbor sever potenti putat probiot gene may confer abil surviv low ph bile resist antibiot stress show antagonist activ pathogen bacteria adher epitheli cell surfac evalu ublg ublpc could degrad oxal vivo prevent hyperoxaluria induc nephrolithiasi rat observ rat treat sodium oxal naox develop hyperoxaluria renal stone howev pre treat ublg ublpc administ naox rat protect sever pathophysiolog manifest hyperoxaluria compar hyperoxalur rat probiot pre treat rat show reduc urinari excret oxal urea p decreas serum blood urea nitrogen creatinin p allevi stone format renal histolog damag overal decreas renal tissu oxal calcium content p taken togeth ublg ublpc effect oxal catabol probiot capabl prevent hyperoxaluria allevi renal damag associ nephrolithiasi

D006959;D007669;D000069980;D019936

T007;T047

enterocin interact broiler rabbit autochthon biofilm form enterococcus hira kr strain young rabbit suscept gastrointestin diseas caus bacteria enterococcus hira associ diseas enterocin produc enterococc speci preventreduc problem therefor interact enterocin biofilm form autochthon e hira kr strain test rabbit assess enterocin potenti vivo rabbit age day sex meat line breed divid four group control c three experiment group rabbit c receiv standard diet rabbit experiment group e receiv cfuml kr dose lanimalday e receiv ent lanimalday e receiv kr ent drink water day experi last day fece blood sampl day start experi fecal mixtur anim n day five fecal mixtur per group n day day addit cessat day four rabbit group slaughter cecum appendix sampl standard microbi analysi ent show decreas tendenc kr use next generat sequenc phyla detect highest abund firmicut verrucomicrobia bacteroidet tenericut proteobacteria cyanobacteria saccharibacteria actinobacteria interact ent phyla result reduc abund percentag day signific increas phagocyt activ pa found e e p kr attack pa stimul oxid stress ent support pa prospect import studi lie benefici interact enterocin host bodi

D001430;D000070076;D011817

T007;T015;T123;T116

geniposid allevi neuropath pain cci rat inhibit egfrpikakt pathway ca channel neuropath pain np common disord among individu worldwid still effect treatment np egfr pathway promot np nocicept sensit repres potenti therapeut target geniposid abund natur plant various pharmacolog activ analgesia anti inflamm properti improv np specif mechan elucid present studi first predict molecular dock geniposid target suggest geniposid may play role improv np target egfr studi clarifi geniposid allevi np improv inflammatori respons use chronic constrict injuri cci model wherea administr egfr agonist weaken effect geniposid analysi transcriptom data suggest geniposid improv cci symptom reduc egfrpikakt pathway activ also may exert anti inflammatori effect inhibit ca signal pathway result affirm potenti valu geniposid treatment np lay foundat clinic applic

D009437;D019869

T047;T184;T126;T116

catalpol amelior neurotox naappsw cell appp transgen mice alzheim diseas ad caus progress declin memori cognit deficit complic pathogenesi prevent therapi ad remain enorm challeng report catalpol possess neuroprotect effect ad howev involv mechan still need intens studi therefor effect catalpol naappsw cell appp mice identifi current studi catalpol could improv cytotox accord cck assay amelior cellular morpholog chang naappsw cell neuron structur damag hippocamp ca region appp ad mice improv accord stain immunohistochemistri neun meanwhil catalpol administr amelior cognit deficit confirm behavior perform appp mice hoechst stain annexin v fitcpi doubl stain demonstr catalpol could reduc apoptosi naappsw cell likewis tunel stain also manifest catalpol signific reduc apoptosi hippocamp ca region appp mice catalpol administr also could improv mitochondri function indic amelior mitochondri morpholog decreas ros generat increas mmp naappsw cell subsequ catalpol restrain oligomer verifi reduc tht fluoresc dose time depend addit aggreg decreas naappsw cell appp mice administr catalpol confirm elisa western blot western blot also show catalpol facilit phosphoryl akt gsk imped express bace vivo vitro final slight alter lactyl hydroxyisobutyryl phosphoryl found naappsw cell treat catalpol togeth find manifest catalpol serv neuroprotect effect ad might novel expect prophylact curat candid ad neurodegen diseas therapi

D000544;D018696;D020258

T047;T037;T121;T048;T169

role pten l modul pink parkin mediat mitophagi inher challeng mitochondria face continu exposur divers stress increas likelihood dysregul respons human cell evolv sophist qualiti control mechan identifi elimin abnorm dysfunct mitochondria one pivot mitochondri qualiti control pathway pinkparkin depend mitophagi mediat select remov dysfunct mitochondria cell autophagi pten induc putat kinas pink mitochondri serthr kinas origin identifi gene respons autosom recess earli onset parkinson diseas pd notabl upon failur mitochondri import parkin anoth autosom recess pd gene recruit mitochondria mediat autophag clearanc deregul mitochondria import recruit parkin damag mitochondria hing accumul pink outer mitochondri membran omm normal pink import cytosol translocas outer membran tom complex larg multimer channel respons import mitochondri protein import pink rapid degrad thus steadi state pink level kept low howev upon mitochondri import failur pink accumul form high molecular weight kda complex tom omm thus pink function sensor tag dysfunct mitochondria parkin mediat mitophagi although much learn function pink mitophagi biochem structur basi negat regul pink oper function far clear recent work unveil new player pten l negat regul pink function herein review key aspect mitophagi pinkparkin mediat mitophagi highlight role negat regul pink function present key futur direct pd cell biolog

D063306;D010300

T043;T047

efficaci safeti modifi bld therapi japanes patient transplant inelig multipl myeloma bld regimen triplet regimen bortezomib bor lenalidomid len dexamethason dex effect newli diagnos multipl myeloma ndmm howev non hematolog toxic peripher neuropathi pn often hamper long term continu regimen particular older adult patient studi examin efficaci safeti modifi bld regimen reduc intens bor standard dose len chemotherapi regimen consist mgm bor administ subcutan day mg len administ day mg dex day week cycl cycl follow week cycl dex mg week among patient enrol ci good partial respons better best overal respons rate ci eight patient achiev complet respons grade higher pn observ hematolog toxic common advers event modifi bld regimen show favor efficaci manag safeti profil suggest could treatment option transplant inelig ndmm

D009101

T191

genom analysi aggress case metastat intrahepat mucin cholangiocarcinoma intrahepat mucin cholangiocarcinoma ihmc rare behav notori howev detail clinicopatholog characterist ihmc remain unknown year old man admit examin hepat mass segment underw extend left hepat lobectomi histopatholog evalu demonstr mix papillari carcinoma compris well moder differenti tubular adenocarcinoma signet ring cell carcinoma larg amount mucus lake tumor relaps month surgeri although receiv chemotherapi combin gemcitabin cisplatin renal failur discontinu chemotherapi receiv palliat radiotherapi metastasi cervic spine patient treat howev die month initi diagnosi autopsi find show multipl nodul lung pleura kidney adren gland stomach pancrea lymph node histolog examin reveal nodul ihmc next generat sequenc reveal somat mutat adgrb tafl epha may affect carcinogenesi taf epha pikcb fn erbb brip syne tgfbr may affect metastasi molecular carcinogenesi ihmc may distinct ordinari cholangiocarcinoma studi need elucid genet mutat function ihmc

D001650;D018281

T191

clean space communiti build urban stage coproduct health park low incom neighborhood green zone potenti contributor health mitig dispar low high incom neighborhood background differ discours citi park park restor environ park enabl place park site encount stranger ethnograph studi coproduct green space health within low incom neighborhood found three compet notion urban green tie differ notion neighborhood well park clean space creat expect order peac park place communiti relat play activ park urban stage foster interact stranger generat experi encompass differ concept health citizen led event contribut shift understand park site neighborhood declin park place hope new begin

D000068316;D012111

T083;T081;T082;T078;T056;T096;T033

examin associ advers childhood experi posttraumat stress disord symptom among young survivor urban violenc studi examin associ advers childhood experi ace exposur posttraumat stress disord ptsd symptom among survivor violenc cross section studi ace questionnair ptsd checklist dsm pcl complet particip month present philadelphia pa emerg depart violent injuri studi treat ace separ cumul exposur ptsd symptom sever outcom particip met criteria provision ptsd report experienc ace report experienc ace specif ace associ increas pcl score increas risk provision ptsd addit particip cumul ace score increas pcl score worsen b p increment ace score increas predict increas odd posit provision ptsd screen result provid evid ace exacerb develop ptsd young survivor violenc futur research explor target intervent treat ptsd among survivor interperson violenc

D000076783;D013313

T048;T033

floccul chlorella vulgari induc algal bloom critic condit mechan algal bloom pose great threat livestock human health although floccul effect effici may hinder direct applic algal bloom studi critic optim condit mechan alcl fecl poli aluminum chlorid pac chitosan polydimethyldiallylammonium chlorid pdadmac induc floccul chlorella vulgari c vulgari studi result identifi critic condit caus floccul effici min five floccul specif mgl dose pdadmac prove appropri treatment c vulgari induc algal bloom ph probe under mechan function group involv floccul zeta potenti speci distribut analyz floccul ft ir result indic n h stretch amin c h deform aliphat involv algal floccul fecl c h deform play import role pdadmac pac chitosan alcl zeta potenti speci distribut result suggest charg neutral adsorpt bridg respons algal floccul ph howev adsorpt bridg sweep effect main mechan ph fecl floccul mechan rest three polym charg neutral adsorpt bridg sweep meanwhil floccul process follow second order kinet strong linkag found rate constant fractal dimens floccul effici p result critic floccul condit mechan indic pdadmac excel floccul c vulgari remov recycl especi water bloom treatment

D048408;D048271

T121;T109;T002

compar studi adsorpt catalyt degrad tetracyclin five magnet miner function materi prepar steel pickl wast liquor palygorskit pal bentonit bent sepiolit sep zeolit zeol kaolin kaol use steel pickl wast liquor synthes magnet palygorskit pal fe magnet bentonit bent fe magnet sepiolit sep fe magnet zeolit zeol fe magnet kaolin kaol fe adsorpt catalyt degrad tetracyclin tc respect studi adsorpt kinet adsorpt isotherm maximum adsorpt capac pal fe tc mgg time time time time bent fe zeol fe kaol fe sep fe respect kinet studi tetracyclin degrad demonstr maximum reaction rate constant bent fe h system k ob min close pal fe h kaol fe h system time time time time fe h zeol fe h sep fe h h system respect result show pal fe bent fe advantag treatment wastewat contain tetracyclin effici reus exhaust magnet miner deep miner organ pollut achiev construct advanc oxid system bet vsm sem xps xrd ftir use character five clay miner magnet modif specul surfac structur oh group clay miner might signific factor influenc adsorpt perform magnet miner tc reduct abil clay miner fe import affect catalyt perform magnet miner specif surfac area morpholog structur clay miner affect adsorpt catalyt degrad tc five magnet miner

D017641;D004785

T131;T197

separ combin effect cadmium cd nonylphenol np growth antioxid enzym hydrochari dubia bl backer cadmium cd consid prioriti pollut nonylphenol np common organ pollut water environ howev ecolog risk combin cd np pollut fulli elucid studi effect cd np cd np growth physiolog hydrochari dubia bl backer studi result indic cd np joint toxic concentr depend joint toxic cd np h dubia antagonist concentr cd np mgl mgl cd np strong synergist effect h dubia addit plant growth signific inhibit chlorophyl content signific reduc cd np cd np exposur plant antioxid enzym system destroy activ superoxid dismutas sod catalas cat signific decreas np exposur activ sod signific decreas cd joint exposur compound pollut exceed oxid defens capac plant h content increas signific result indic ecotox np combin cd may exacerb aquat environ caus obvious damag h dubia

D031321;D004785

T131;T002

activ peroxymonosulf modifi coagul sludg bisphenol degrad studi use coagul sludg landfil leachat treatment prepar modifi coagul sludg mcs catalyst limit oxygen pyrolysi method adsorpt degrad effici reaction mechan bisphenol bpa mcs activ peroxymonosulf mcspms process investig pyrolysi temperatur determin adsorpt capac activ abil mcs pyrolysi temperatur c h mcs test materi best adsorpt capac bpa mcs prepar pyrolysi temperatur c h better catalyt perform toward pms mcspms process bpa mgl could complet degrad min room temperatur initi ph pms dosag gl mcs dosag gl radic quench experi indic hydroxyl radic oh sulfat radic exist mcspms process oh play major role bpa degrad chang morpholog function group compon surfac element valenc state mcs catalyst reaction investig found bpa degrad reaction coupl adsorpt oxid process homogen situ heterogen effect includ reaction addit stabil mcspms process verifi differ environment scenario includ ultrapur water tap water municip wastewat furthermor degrad intermedi p hydroxyl phenol p hydroxybenzo acid bpa determin ultra perform liquid chromatographi quadrupol time flight mass spectrometri reaction mechan mcspms process investig

D012722;D014874

T069;T131

determin toxic metal burden relat risk factor pregnant women biolog monitor sabzevar iran nowaday advers effect toxic metal human well known especi fetal period prevent cognit develop congenit abnorm central nervous system henc studi aim evalu toxic metal burden mother newborn sabzevar obtain data use author public health issu determin heavi metal placent blood umbil cord blood one hundr eighti blood sampl taken nineti mother refer shahidan mobini hospit deliveri amount metal sampl analyz use induct coupl plasma optic emiss spectrometri icp oe result studi reveal matern blood sampl placent blood umbil cord blood sampl higher us center diseas control cdc recommend level pb cd respect accord multipl linear regress analysi pb p p se p level associ mother live area also signific associ se age mother howev se valu optimum concentr blood gl decreas advers effect toxic metal pregnant women se valu gl pregnant women se level higher gl conclud mother inhabit rural area need se sourc diet

D000079687;D019216

T057;T196

handheld two stroke engin import sourc person voc exposur oliv farm worker person exposur volatil organ compound voc main associ indoor exposur howev elev short term exposur may also occur ambient activ handheld two stroke gasolin power engin widespread use agricultur far studi conduct potenti health risk due inhal emit voc one week passiv sampl conduct oliv farm worker harvest season monitor person exposur level voc first group worker select repres contribut gasolin power shaker daili person voc exposur one anoth group worker select control whose use devic higher concentr penten n hexan isopentan n penten toluen observ person sampl collect machin oper person exposur concentr total monitor voc vari g among volunt worker estim carcinogen risk accept level worker individu chronic hqs sum individu hqs benchmark valu regular worker differ sampl site wherea hi valu acut short term chronic exposur scenario exceed shaker machin oper repres potenti non carcinogen health hazard expos shaker oper along elev voc

D055549;D000393;D031658;D020521

T047;T002;T131;T109;T168

bioavail inhal ingest pfoa adsorb hous dust indoor environ may impact human health due chemic pollut indoor air hous dust studi aim compar bioavail distribut pfoa follow inhal oral exposur pfoa coat hous dust rat addit extract organofluorin eof measur differ tissu sampl assess potenti influenc organofluorin compound experiment hous dust blood sampl collect sequenti time point exposur time termin lung liver kidney collect quantif pfoa eof concentr pfoa plasma increas rapid exposur group attain c max h post exposur c max follow inhal four time higher compar oral exposur h post exposur level pfoa plasma liver kidney twice high inhal exposur show pfoa readili bioavail rapid system distribut follow inhal oral exposur hous dust coat pfoa proport pfoa eof correspond plasma tissu respect mass balanc eof target pfoa indic might unknown pfas precursor andor fluorin compound co exist hous dust sampl accumul rat

D005466;D004785

T109;T131

compar analysi renew non renew energi generat releg co emiss general cost household system ensur adequ implement solar energi provid environ friend energi household sector consider abat pollut environ make power industri structur sustain necessari develop countri comparison term environment cost impact renew energi hybrid solar system non renew energi sourc water plan develop author wapda diesel generat dgs examin household sector pakistan primari data hybrid solar system obtain differ household segreg two categori accord incom medium incom household mih lower incom household lih contain kw kw hybrid solar energi system respect oper hybrid solar energi system instead non renew energi system term averag generat power averag run load carbon dioxid co emiss reduc kg co kg co respect next year comparison cost indic renew energi compar low cost per electr unit pay back total instal cost year save sum along mani ecolog econom societ benefit pakistan effici util solar energi releg co emiss general cost distinct geograph featur access sunlight day year

D012993;D004785

T131;T070

investig mitochondri relat variant cerebr small vessel diseas cohort monogen form cerebr small vessel diseas csvd caus variant nuclear dna mitochondri dna mtdna mitochondri encephalopathi lactic acidosi stroke like episod mela known phenotyp similar cerebr autosom domin arteriopathi sub cortic infarct leukoencephalopathi cadasil caus variant mitochondri genom sever nuclear encod mitochondri protein nemp gene aim studi screen variant mitochondri genom nemp gene notch negat cadasil cohort identifi potenti link mitochondri dysfunct csvd patholog whole exom sequenc perform patient cadasil like symptomolog ion torrent system mitochondri sequenc perform use hous design protocol sequenc run ion genestudio plus nemp gene mitochondri sequenc data examin rare maf non synonym variant predict deleteri effect protein identifi candid nemp variant link either mela encephalopathi alzheim diseas relat phenotyp base chang variant affect polg mto lonp ndufaf ndufb tcirg thought play potenti role csvd patholog cohort overal explor mitochondri genom identifi potenti role mitochondri relat protein mtdna variant contribut csvd patholog

D046589;D059345;D056784;D017241;D020521;D025262

T047;T126;T116

role ubiquitin proteasom autophagi lysosom pathway synuclein aggreg clearanc synuclein aggreg neuron cell primari under caus synucleinopathi chang gene express pattern structur modif alter interact cellular protein often trigger aggreg synuclein accumul oligom fibril lewi bodi although fibrillar form synuclein primarili consid patholog recent studi reveal even intermedi state aggreg neurotox complic develop therapeut intervent autophagi ubiquitin proteasom pathway play signific role maintain solubl level synuclein insid cell howev heterogen natur aggreg present signific bottleneck degrad cellular pathway studi focus identifi protein modul synuclein aggreg clearanc detail mechanist insight emerg individu synergist effect degrad pathway regul solubl synuclein level articl discuss impact synuclein aggreg autophagi lysosom ubiquitin proteasom pathway therapeut strategi target various aspect synuclein aggreg degrad via pathway addit also highlight natur synthet compound shown promis allevi cellular damag caus due synuclein aggreg

D010300;D051844

T047;T123;T116

intraven thrombolysi endovascular thrombectomi acut ischaem stroke patient moyamoya diseas systemat review meta summari case report patient moyamoya diseas mmd present ischaem haemorrhag stroke good evid treatment strategi mmd associ acut ischaem stroke ai particular treatment like intraven thrombolysi ivt endovascular thrombectomi et intracrani vessel friabl mmd risk bleed high use ivt et controversi clarifi safeti efficaci ivtet treatment mmd associ ai perform systemat review meta summari examin issu

D002545;D000083242;D009072;D020521

T047;T046

survey internist recommend aspirin older adult barrier evid base use recent trial suggest aspirin primari prevent may harm good includ adult year age sought assess primari care provid pcps use aspirin primari prevent older patient identifi barrier use accord recent guidelin recommend routin use patient age survey pcps whether would recommend aspirin clinic vignett year old patient year atherosclerot cardiovascular diseas risk also queri perceiv difficulti follow guidelin recommend well perceiv barrier facilit obtain respons pcps respons patient vignett clinician recommend aspirin use vari whether patient use aspirin initi p believ aspirin benefici perceiv barrier guidelin base aspirin use includ concern patient upset possibl malpractic claim strategi discuss aspirin use estim adjust probabl rate guidelin hard follow higher clinician believ aspirin benefici vs p worri patient would upset told stop aspirin vs p internist vari consider recommend aspirin use primari prevent older patient high proport pcps continu believ aspirin benefici set result inform de implement effort optim evid base aspirin use

D001241;D010820

T121;T109;T097

bone marrow mesenchym stem cell deriv exosom microrna b p promot angiogenesi ventricular remodel rat myocardi infarct target adamt increas amount evid suggest microrna mir play role myocardi infarct mi studi aim discuss impact exosom mir b p mi regul disintegrin metalloproteinas thrombospondin motif adamt exosom extract bone marrow mesenchym stem cell bmscs rat model mi myocardi angiogenesi ventricular remodel relat factor well myocardi fibrosi collagen volum fraction cvf capillari densiti level vascular endotheli growth factor vegf apoptosi cardiomyocyt test adamt mir b p level myocardi tissu mi rat test mir b p express decreas adamt express increas myocardi tissu mi rat adamt target gene mir b p upregul mir b p deliv bmsc deriv exosom improv myocardi angiogenesi ventricular remodel reduc myocardi fibrosi cvf increas capillari densiti vegf express suppress apoptosi cardiomyocyt mi rat adamt overexpress acceler mi rat adamt upregul revers protect effect mir b p upregul mi rat studi provid evid upregul mir b p deliv bmsc secret exosom improv myocardi angiogenesi ventricular remodel rat mi target adamt

D059630;D035683;D009203

T025;T123;T047;T114

fatal intox new synthet cannabinoid f mdmb pica f mdmb binaca parent compound metabolit identif blood urin cerebrospin fluid synthet cannabinoid scs remain one largest group new psychoact substanc recent new synthet cannabinoid f mdmb pica f mdmb binaca increas popular year old man lost conscious smoke unknown substanc glass pipe two lump substanc turn contain f mdmb pica f mdmb binaca found scene blood urin cerebrospin fluid collect examin bodi synthet cannabinoid isol autopsi materi precipit acetonitril extract ethyl acet screen quantit analys perform liquid chromatographi tandem mass spectrometri lc msms liquid chromatographi quadrupoletim flight mass spectrometri lc qtof techniqu use metabolit identif f mdmb pica detect quantifi analys materi wherea f mdmb binaca found cerebrospin fluid determin concentr f mdmb pica blood urin ngml cerebrospin fluid concentr f mdmb binaca cerebrospin fluid ngml main metabolit compound hydrolysi oxid defluorin found analys bodi fluid cerebrospin fluid may import altern materi autopsi case rapid elimin f mdmb pica f mdmb binaca compound also mean metabolit analysi crucial investig laboratori must made awar presenc incorpor scs metabolit workflow detect confirm ester hydrolysi oxid defluorin product found blood urin cerebrospin fluid make use biomark intak

D013287;D002186;D001826

T121;T109;T131;T031

time zero hsqc method improv linear free energi relationship polypeptid chain accur measur residu specif equilibrium constant exsi exchang spectroscopi nmr provid residu specif equilibrium constant k residu specif kinet rate constant k polypeptid chain two state exchang slow exchang regim linear free energi relationship lfer discov log k versus log k plot consid physicochem basi smooth fold conform chang protein molecul accur determin thermodynam kinet paramet measur bias aris state specif differ r r relax rate h nuclei hsqc exsi experi must minim show time zero hsqc acquisit scheme hsqc effect purpos combin special analyt method analysi exsi exampl appli hsqc method two state exchang nukacin isk aqueous solut nukacin isk residu lantibiot peptid contain three mono sulfid linkag result bias free residu base lfer provid valuabl insight transit state topolog interconvers nukacin isk found two amino acid residu except residu base lfer relationship infer two residu could adopt special conform transit state allow thread side chain ring structur form one mono sulfid linkag context two residu use target manipul physicochem properti biolog activ nukacin isk

D000596;D010455

T121;T123;T116

compar outcom decompens chronic hepat b patient treat entecavir tenofovir year cohort studi whether efficaci entecavir etv tenofovir disoproxil fumar tdf treat liver relat outcom decompens chronic hepat b chb patient compar remain inconclus

D058625;D019694;D008113

T191;T047

novel epitheli mesenchym transit gene signatur immun status prognosi hepatocellular carcinoma studi clarifi whether emt relat gene predict immunotherapi efficaci overal surviv patient hcc

D006528;D008113

T191

limit access antipsychot canada loss old unavail new option schizophrenia sever debilit disord associ signific burden ill antipsychot medic remain mainstay treatment schizophrenia relat disord recent year number new psychotrop medic introduc market potenti differ mechan action compar previous one paper discuss issu lack access newer antipsychot canada discontinu older option market leav clinician patient limit number avail option aim paper increas awar current state avail access option discuss potenti solut

D014150;D012559

T121;T048;T039

covid social distanc lifestyl health outcom among person live hiv plwh web base survey investig chang lifestyl depress symptom self percept health bodi weight chang person live hiv plwh covid social distanc sd web base cross section survey particip n question lifestyl health status sd respond men year old high educ level incom reduc sd diagnos covid requir hospit sd particip chang food intak although replac healthi food unhealthi one half mention poor sleep qualiti increas sedentari behavior depress symptom report associ sedentari behavior poor sleep qualiti reduc incom one third negat percept health status invers associ practic physic exercis posit associ sedentar poor sleep qualiti half increas bodi weight associ lower intak veget older age reduc odd three outcom care monitor plwh regard sd enabl earli intervent toward health

D000086382;D015658;D007319

T047;T184;T067;T048

overview sucros transport sut gene famili rice photosynthesi provid energi basi life activ plant produc organ compound main sugar main energi form photosynthesi sugar affect growth develop plant long distanc transport sucros main form transport rate sugar transport alloc carbohydr affect biomass crop close relat reproduct growth crop

D012275

T168;T002

inflammatori associ apoptot marker culprit rheumatoid arthriti pain rheumatoid arthriti ra prolong inflammatori diseas result autoimmun reaction lead local system bone eros joint defect function impair although inflamm subsid prescript anti inflammatori therapeut patient persist complain sleepless night due flare pain indic possibl contribut pathway besid inflamm lead ra pain review aim uncov role involv sever inflammatori associ apoptot marker facilit pain transmiss process pathogenesi ra

D001172

T047

neuroprotect effect glycyrrhetin acid bisphenol induc neurotox rat involv neuron apoptosi endoplasm reticulum stress jakstat signal pathway exposur bisphenol bpa inevit owe common use product polycarbon plastic studi reduc side effect gain import sinc bpa caus sever toxic import tissu test lung brain liver kidney current studi plan studi amelior effect glycyrrhetin acid ga bpa induc neurotox fourti wistar albino rat divid five equal group follow control group ii ga group mgkg iii bpa group mgkg iv mgkg bpa mgkg ga group v mgkg bpa mgkg ga group bpa intox associ increas mda level reduc gsh concentr activ glutathion peroxidas superoxid dismutas catalas bpa supplement caus apoptosi brain regul caspas bax level regul bcl bpa also caus endoplasm reticulum er stress increas mrna transcript level perk ire atf grp addit observ bpa administr activ jakstat signal pathway level tnf nf b p mapk jnk brain howev co treatment ga dose mgkg consider amelior oxid stress inflamm apoptosi er stress jakstat signal pathway brain tissu overal data studi indic brain damag associ bpa toxic could amelior ga administr

D059865;D018696

T121;T169;T049

stress condit induc circrna profil extracellular vesicl brain microvascular endotheli cell cerebr ischemia caus hypox injuri inflamm brain microvascular endotheli cell bmvec dysfunct initi stage blood brain barrier disrupt endotheli cell secret extracellular vesicl ev involv intercellular signal transduct ev contain varieti rnas protein metabolit circular rna circrna member non code rna express profil potenti function circrna bmvec unknown human bmvec undergon hypoxia tnf induct chang circrna measur rna sequenc total circrna show differenti express includ previous unrecord circrna record circrna sinc astrocyt end feet encircl endotheli cell consid main target ev bmvec mirna sequenc data bioinformat use predict circrna mirna mrna network astrocyt gene ontolog go analysi show main downstream target circrna dna transcript regul protein kinas relat signal pathway result suggest alter circrna may potenti therapeut target cerebr ischemia induc hypox injuri inflamm

D002545;D000067128;D035683

T047;T046;T026;T123;T114

lysobact chinensi sp nov cellulos degrad strain isol cow dung compost novel bacteri strain tlk ck isol cow dung compost sampl strain gram stain negat non glide rod aerob display growth c optim c wv nacl optim ph optim assembl genom strain tlk ck total length mb g c content accord genom analysi strain tlk ck encod quit glycosid hydrolas may play role degrad accumul plant biomass compost basi rrna gene sequenc analysi strain tlk ck show highest sequenc similar l penaei gdmcc follow l mari kctc cell contain iso c iso c sum featur compris c c andor methyl c major cellular fatti acid ubiquinon exclus respiratori quinon diphosphatidylglycerol phosphatidylethanolamin phosphatidylglycerol prevail among phospholipid base phenotyp genom phylogenet data strain tlk ck repres novel speci genus lysobact name lysobact chinensi sp nov propos type strain tlk ck cctcc ab kctc

D000076282;D053528

T007;T068;T167

combin analysi receptor express reflect inter intra tumor heterogen hrher breast cancer hormon receptor posit human epiderm growth factor receptor posit hrher breast cancer compris approxim invas breast cancer howev lack knowledg regard complex tumor heterogen hrher diseas remain barrier accur therapi studi aim describ tumor heterogen hrher breast cancer establish novel indic identifi enrich subtyp patient hrher breast cancer

D001943

T191

stall intersect insur status dispar post mastectomi breast reconstruct post mastectomi breast reconstruct pmbr import compon breast cancer treatment dispar relat insur status persist despit legisl target issu aim studi relationship larg health system combin safeti net hospit privat academ center

D001943;D016462

T191;T061

elev chang product sapl relat distribut two congener tree speci elev chang veget associ chang environment factor exampl provid shade toler abi mariesii less shade toler abi veitchii domin forest high low elev respect subalpin zone central japan studi sought establish factor under differenti elev domin two speci perspect sapl growth surviv assum growth surviv sapl greater higher rate surplus product valu obtain subtract minimum net product maintain current sapl leaf mass total net product sapl leaf mass gradual declin time sapl maintain current sapl leaf mass therebi increas risk prematur mortal regard aim verifi follow two hypothes low elev surplus product rate veitchii greater mariesii canopi gap vice versa forest understori high elev surplus product rate mariesii greater veitchii forest understori canopi gap result obtain studi consist two state hypothes addit low elev site rate growth height veitchii canopi gap greater mariesii indic veitchii domin disturb low elev find studi indic differenti elev distribut two abi speci attribut interspecif differ surplus product rate believ find use predict chang distribut veget respons climat chang

D028202;D014197

T002

anticoagul rodenticid use oil palm plantat southeast asia hazard assess non target anim anticoagul rodenticid ar use worldwid control rodent pest main method control rat pest popul agricultur area main aim review discuss risk ar non target wildlif oil palm area southeast asia main indonesia malaysia discuss ar use oil palm area toxic ar target non target anim also review publish literatur wildlif speci report oil palm area southeast asia util inform assess hazard risk ar non target wildlif oil palm plantat ar secondari exposur hazard rodent consum mammalian carnivor leopard cat civet rodent consum raptor barn owl consumpt dead poison prey put scaveng water monitor high risk ar exposur domest livestock granivor bird high risk ar exposur via primari exposur toxic bait omnivor macaqu wild pig moder risk primari secondari exposur ar effect ar barn owl well studi field laboratori secondari toxic studi thus nest box occup reproduct paramet local barn owl popul monitor indic ar exposur level area clinic trial registr clinic trial involv studi

D020304;D012378;D020305

T012;T131

earli infiltr phase gbm hypothesi molecular glioblastoma histolog glioblastoma make preliminari multicent studi presenc necrosi microvascular prolifer previous hallmark glioblastoma gbm diagnosi classif consid idh wildtyp diffus astrocyt tumor without histolog featur glioblastoma would otherwis classifi grade molecular gbm molgbm harbor follow molecular abnorm tert promot mutat egfr amplif chromosom copi chang hypothes tumor earli histolog gbm eventu develop classic histolog featur

D001932;D005909

T191

perceiv durat expect event depend expect form repeat event seem shorten suggest result invers relationship predict perceiv durat predict event seem shorter evid disput generalis case relationship nullifi even revers studi sought combin differ factor encourag expect singl paradigm direct compar effect find peopl ask declar predict ie predict colour sequenc ensu guess confirm event seem relat protract augment posit time order error first two sequenti present alreadi seem protract observ contract perceiv durat probabl repeat event overal result inconsist simpl map predict perceiv durat whether perceiv durat expect event seem relat contract expand seem conting causal origin expect

D013998

T041

telephon base frontal assess batteri fab standard italian popul clinic usabl neurolog diseas despit relev telephon base cognit screen test clinic practic research specif test assess execut function avail present studi aim standard provid evid clinic usabl italian telephon base frontal assess batteri fab

D056344;D009422

T047;T041

high intens interv train modul inflammatori respons parkinson diseas recent discoveri show high intens interv train hiit bring mani posit effect decreas fat tissu lower blood sugar level improv learn memori lower risk cardiac diseas parkinson diseas pd neurodegen disord character loss dopaminerg neuron accompani chronic inflamm neuroinflamm previous research show interv train bring benefici effect inflamm neuroplast pd

D000072696;D007249;D010300

T056;T061;T046;T047

review precis medicin approach genet cardiomyopathi target phospholamban rdel heart failur syndrom poor prognosi curat option major patient standard one size fit treatment approach target neurohormon dysregul help modul symptom heart failur fail address caus problem precis medicin aim go beyond symptom modul target pathophysiolog mechan underli diseas review overview precis medicin approach treatment strategi genet heart diseas discuss pln rdel genet mutat known caus cardiomyopathi use exampl describ potenti pitfal precis medicin

D009202;D006333

T047;T046

percutan manag breast cancer systemat review surgic treatment breast cancer becom increas minim invas review develop status percutan manag primari breast cancer evid relat tumor size fundament determin treatment clinic outcom

D001943;D017115

T191;T061

serial tumor molecular profil newli diagnos negat breast cancer chemotherapi combin angiogenesi inhibitor breast cancer heterogen variabl clinic cours treatment respons

D001943;D064726

T191

mir b p attenu neuropath pain regul px receptor spinal cord mice px receptor pxr upregul nerv injuri mediat spinal microgli activ make critic contribut patholog enhanc pain process dorsal horn although studi part clarifi mechan under alter pxr express specif mechan well understood microrna mirna small noncod rnas control gene express bind target mrnas thus present studi investig whether mirna involv pathogenesi neuropath pain regul pxr result show pxr upregul spinal dorsal horn mice follow spare nerv injuri sni mirna upregul downregul mirna differenti express fold chang p pxr found major target mir b p one downregul mirna use bioinformat technolog quantit real time pcr analysi confirm chang express mir b p dual luciferas report assay confirm correl fluoresc situ hybrid use show cell co local pxr mir b p spinal dorsal horn transfect mir b p mimic bv cell revers upregul pxr induc lipopolysaccharid lps moreov mir b p overexpress signific attenu neuropath pain induc sni decreas express pxr mrna protein spinal dorsal horn intrathec mir b p antagomir induc pain behavior increas express pxr spinal dorsal horn nave mice data suggest mir b p serv import regul neuropath pain develop target pxr

D035683;D009437

T047;T184;T123;T114

one level open vs minim invas transforamin lumbar interbodi fusion systemat review advanc meta analyt assess prospect studi least two year follow determin whether open minim invas transforamin lumbar interbodi fusion tlif mi tlif favor treatment provid first meta analys use prospect studi least two year follow present clinic relev statist result first time

D008159;D013123

T061;T023

knowledg attitud behavior imam prostat cancer kahramanmara turkey imam muslim religi leader turkey signific influenc societi healthcar attitud behavior male studi aim investig knowledg attitud imam toward prostat cancer pca order evalu contribut fight pca one part turkey studi carri imam serv kahramanmara provinc turkey questionnair investig sociodemograph characterist particip knowledg attitud behavior pca conduct mean age imam min max particip said heard pca heard prostat specif antigen psa test major imam poor knowledg regard pca knowledg score imam chang accord marit status p educ level p knowledg score signific increas age group age increas p result present studi reveal imam lack signific knowledg pca train pca organ imam issuanc fatwa pca encourag coordin work media medic personnel religi offici religi school pca import factor fight pca

D002977;D011471

T191;T097

moraxella tetraodoni sp nov isol freshwat pufferfish tetraodon cutcutia skin novel aerob bacterium strain ps genus moraxella isol skin freshwat pufferfish tetraodon cutcutia cell gram stain negat aerob non motil coccoid optimum growth occur c ph major cellular fatti acid c c c c c anteiso predomin polar lipid diphosphatidylglycerol phosphatidylglycerol phosphatidylethanolamin phospholipid amino lipid seven unknown lipid genom size mbp dna g c content gene ontolog studi reveal major fraction gene associ biolog process follow molecular function cellular compon comparison rrna gene sequenc reveal sequenc similar close relat type strain genus moraxella averag nucleotid ident ani averag amino acid ident aai strain ps refer type strain genus moraxella correspond silico dna dna hybrid ddh valu phylogenet tree base genom wide core gene rrna gene sequenc reveal strain ps cluster moraxella osloensi ccug phylogenet tree genotyp phenotyp characterist strain ps repres novel speci moraxella tetraodoni sp nov propos type strain ps tbrc nbrc

D023721

T013

leber hereditari optic neuropathi plus dystonia caus mitochondri nd gene c mutat leber hereditari optic neuropathi lhon common mitochondri diseas variant mitochondri dna mtdna previous describ lhon howev pathogen variant remain unclear herein report year old boy present uniqu lhon plus dystonia syndrom rare g c variant elucid molecular pathomechan c mutat

D004421;D029242

T047;T184

immunolog axi involv interleukin leucin rich glycoprotein reflect therapeut respons children kawasaki diseas implic kawakinra trial recent phase ii open label studi interleukin il receptor antagonist il ra anakinra treat ivig resist kawasaki diseas kd patient report promis result aim character immunolog impact il blockad uniqu studi popul

D009080

T047

mesenchym stem cell attenu acut lung injuri mice part suppress alveolar macrophag activ pge depend manner mesenchym stem cell mscs demonstr attenu acut lung injuri ali also found suppress activ alveolar macrophag am part account therapeut effect mscs inher immunosuppress effect co cultur inflammatori immun cell mscs activ inflammatori cytokin meanwhil exert immunosuppress effect order research rna sequenc rna seq mscs cultur co cultur activ macrophag perform data suggest total differenti express gene deg along process use data upregul deg develop signal network gene transcript factor target order predict alter function mscs exposur inflammatori stimuli construct network reveal critic target gene potenti role mscs inflammatori condit accord network ptgs assum import gene particip immunosuppress effect mscs also identifi signific increas express cox protein secret pge mscs use cox inhibitor ns restrain secret pge revers suppress macrophag activ mscs vitro addit select antagonist pge bind receptor ep receptor gwx also revers inhibitori effect mscs am protect effect ali mous summari therapeut effect mscs ali part occur suppress activ via pge bind ep receptor

D055371;D045164;D059630

T061;T025;T037

hemophagocyt lymphohistiocytosi diagnos bone marrow trephin biopsi live post covid patient case report mini review hemophagocyt lymphohistiocytosi hlh constitut life threaten inflammatori syndrom postmortem histolog find bone marrow bm covid patient show histiocytosi hemophagocytosi support hypothesi secondari hlh shlh may trigger sar cov infect howev limit number shlh case trephin perform live post covid patient present recent case mini review shlh diagnos trephin biopsi live patient covid year old man past medic histori hypertens diabet ischem stroke refer hospit evalu leukocytosi pyuria elev inflammatori marker four week recov covid comput tomographi abdomen reveal focal sign infect hepatosplenomegali patient receiv intraven meropenem two pack red blood cell unit leukocyt c reactiv protein gradual decreas bm biopsi perform patient discharg cefixim bm smear reveal sever anemia lymphopenia dysplast morpholog find erythroblast neutrophil megakaryocyt trephin biopsi reveal hypercellular marrow dyserythropoiesi plasmacytosi lymphocytosi histiocytosi hemophagocytosi absenc granuloma carcinoma immunohistochemistri document mix popul lymphocyt cd b lymphocyt cd strong posit cd confirm histiocytosi cd stain prove polyclon plasmacytosi perl stain show excess hemosiderin deposit base find document shlh trephin bm biopsi live post covid patient persist leukocytosi underscor diagnost valu trephin biopsi prevent life threaten condit covid

D000086382;D051359

T047;T067

statin pregnanc justifi earli treatment reproduct age women statin pillar secondari prevent reduc cardiovascular diseas high risk adult howev statin discontinu standard recommend pregnant lactat patient review evalu whether justifi earli treatment reproduct age women statin therapi

D050197;D002318;D019161

T121;T047;T046;T109

prevent coronari arteri diseas women cardiovascular diseas remain lead caus morbid mortal women women histor underrepres landmark trial cardiovascular guidelin base prone gender specif risk factor predispos coronari heart diseas

D002318;D003324;D011225

T047;T046

aso author reflect opportun provid cost conscious care patient undergo crs hipec substanti cost care patient undergo cytoreduct surgeri hypertherm intraperiton chemotherapi augment chang practic pattern report discuss recent public author group thought cost conscious cancer care

D006979;D010534

T191;T061

much pain surgeri preoper nomogram predict acut pain follow mastectomi acut postop pain affect time opioid cessat qualiti life associ chronic pain effect screen tool need identifi patient increas risk experienc sever acut postop pain may benefit multimod analgesia earli pain manag referr studi develop nomogram preoper identifi patient high risk moder sever pain follow mastectomi

D059787;D001943

T191;T184

first line immunotherapi impact efficaci later treatment discuss use second progress free surviv research endpoint current cancer immunotherapi efficaci measur endpoint progress free surviv overal surviv unabl reflect authent respons checkpoint inhibitor clinic trial second progress free surviv howev could ideal surrog endpoint due easi measur correl overal surviv abil evalu efficaci sequenti therapi commentari summar second progress free surviv data clinic trial investig first line anti pd pd l therapi patient metastat solid tumor specul first line immunotherapi exert posit influenc efficaci later therapi patient cancer type though addit research urgent warrant

D007167;D009369

T191;T061

effect photobiomodul reduc pain produc dental analgesia systemat review photobiomodul pbm report mani studi produc dental analgesia without produc thermal damag tissu systemat review aim assess vivo studi support statement pbm produc dental analgesia

D000698

T061

surgic manag laryng bilater abductor palsi compar studi carbon dioxid diod laser studi aim compar result co laser diod laser combin arytenoidectomi posterior cordectomi manag patient bilater vocal fold paralysi prospect studi involv bilater vocal cord immobl patient adduct divid two group accord laser use whether co wavelength diod wavelength nm use mmrc modifi medic research council dyspnea scale assess dyspnea patient voic evalu maximum phonat time voic handicap index quantit variabl describ use mean standard deviat categor variabl describ use frequenc compar use chi squar test fisher exact test mont carlo test statist non signific differ studi group regard mmrc dyspnea scale voic handicap index preoper postop statist signific differ two group regard maximum phonat time postop signific higher co laser group p co laser diod laser could use safe manag bilater vocal cord paralysi co laser maintain better voic paramet less postop pain diod laser give less oper time lower cost simplic use

D053685;D054020;D014826

T047;T073;T061;T074;T033

size segreg disk particl two dimension chute size segreg lead stratif particl system present peopl fulli understood segreg mechan work studi size segreg behavior two compon disk particl chute flow effect particl size ratio particl densiti static friction coeffici chute angl size segreg discuss use discret element method simul calcul forc disk larg particl segreg result show squeez expuls mechan play key role size segreg disk particl flow establish physic model squeez expuls disk particl obtain condit format squeez expuls mechan

D010316

T081

circular rna hecw regul inflammatori imbal spinal cord injuri via mir plrrtm axi spinal cord injuri sci neurolog diseas devast effect result develop system inflamm howev molecular mechan sci remain entir elucid studi direct toward explor circ hecw involv mechan lipopolysaccharid lps trigger inflamm damag neuron cell vitro model sci base pc cell establish lipopolysaccharid cell prolifer determin use cell count kit cck express circhecw mir p inflammatori factor measur quantit real time pcr elisa assay flow cytometri use assess apoptosi western blot analysi perform purpos determin lrrtm nf kb signal express circ hecw tnf il il lps trigger pc cell express mir p il signific decreas knockdown circhecw promot prolifer inhibit apoptosi reduct inflammatori cytokin express studi reveal circhecw regul sci neuron cell inflamm imbal regul mir plrrtm signal

D035683;D013119

T123;T037;T114