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biomedical-topic-categorization-validation

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immobil cytochrom c benzoic acid ba function uio enzym activ assay recent metal organ framework mof consid moder host bio enzym owe uniqu pore control surfac affin target molecul work benzoic acid ba modul uio introduc cytochrom c cyt c chosen target enzym evalu immobil effici result uio ba immobil condit includ ph adsorpt time temperatur initi concentr ba optim adsorpt kinet thermodynam analyz explor enhanc adsorpt mechan worth note uio ba exhibit evid enhanc adsorpt capac comparison unmodifi uio due format chemic bond uio ba cytochrom c indic posit role ba modif final activ immobil cytochrom c assess use catalyt oxid abt presenc h reaction also conduct free cytochrom c comparison evid improv stabil definit ph rang prolong durabl organ solvent good reusabl immobil cytochrom c highlight prospect applic function mof immobil enzym practic catalyt reaction

D000073396

T109

investig morchella esculenta morchella conica antibacteri potenti methicillin suscept staphylococcus aureus methicillin resist staphylococcus aureus streptococcus pyogen antimicrobi resist alarm problem especi due emerg methicillin resist staphylococcus aureus mrsa world health organ alreadi list mrsa top prioriti pathogen develop novel antibacteri agent present differ therapeut approach bacteri infect practic includ target bacteri virul factor bacteriophag therapi manipul microbiom natur product effici use centuri combat bacteri infect morchella natur fungal product report possess broad spectrum biolog activ bacteri infect henc studi aim evalu antibacteri efficaci two macro fungi aureus mrsa streptococcus pyogen pyogen antibacteri potenti fungal extract morchella esculenta morchella conica evalu use disk diffus standard broth microdilut method chemic compound fungi investig use ultra perform liquid chromatographi mass spectroscopi uplc ms analysi fungal extract inhibit growth test bacteria inhibitori zone rang mm minimum inhibitori concentr mic test bacteri growth rang mgml noteworthi morchella extract prevent aureus growth bactericid manner minim bactericid concentr mbc mgml extract also effect mrsa current avail antibiot conclus growth inhibit test bacteria fungal extract reveal potenti antibacteri agent compound may use drug candid

D055624

T007

substitut bout sedentari behavior physic activ adopt posit lifestyl choic peopl histori cancer determin peopl histori cancer whether substitut sit time daili activ ie sleep walk moder vigor physic activ associ chang waist circumfer wc import surrog marker cardiometabol risk

D009369;D057185

T191;T079;T033

race report dispar regard clinic trial bladder cancer systemat review systemat review literatur investig racial dispar among bladder cancer clinic trial enrolle

D001749

T191

triazolyl ru ii os ii ir iii complex potenti hiv inhibitor infect human immunodefici virus give rise acquir immunodefici syndrom still major global health challeng million peopl affect use combin antiretrovir therapi great success lead reduc mortal rate year although success drug associ various side effect necessit develop new treatment strategi studi investig three metal base complex previous shown possess anticanc activ complex investig three pseudovirus consist hiv subtyp c cap du subtyp q complex inhibit viral entri low micromolar concentr ic valu rang n aryl h triazol base cyclometal ruthenium ii n aryl h triazol base cyclometal iridium iii b n aryl h triazol base cyclometal osmium ii complex c inhibit signific signific inhibit ligand alon similar concentr addit concentr non toxic mammalian cell complex analys potenti mechan action use silico dock maestro indic activ potenti due interact ccr co receptor predict interact involv amino acid glu tyr tyr essenti interact chemokin receptor viral gp

D000970;D056831;D015497;D012428

T121;T109;T196;T104;T005

overexpress laminin gamma promot tumorigenesi pancreat ductal adenocarcinoma egfrerkaktmtor cascad pancreat ductal adenocarcinoma pdac correl poor outcom limit therapeut option laminin gamma lamc play critic role key biolog process howev detail molecular mechan potenti role lamc pdac stay unexplor present studi examin essenti role molecular mechan lamc tumorigenesi pdac identifi lamc signific upregul microarray cohort tcga rna sequenc data pdac patient compar non cancerousnorm tissu patient higher transcript level lamc correl clinic stage dismal overal well diseas free surviv addit confirm signific upregul lamc panel pdac cell line pdac tumor specimen contrast normal pancreat tissu cell inhibit lamc signific decreas cell growth clonogen abil migrat invas pdac cell tumor growth pdac xenograft model mechanist silenc lamc suppress express zeb snail n cadherin cdh vimentin vim induc e cadherin cdh express lead revers mesenchym epitheli phenotyp interest co immunoprecipit experi demonstr lamc interact epiderm growth factor receptor egfr stabl knockdown lamc inhibit phosphoryl egfr erk akt mtor ps kinas signal cascad pdac cell altogeth find suggest silenc lamc inhibit pdac tumorigenesi metastasi repress epitheli mesenchym transit modul egfrerkaktmtor axi could potenti diagnost prognost therapeut target pdac

D021441;D007797;D020935;D010190;D051057;D058570

T116;T191;T126;T123;T044

characterist microbiota metabol profil high temperatur daqu differ grade superior grade daqu sdaqu normal grade daqu ndaqu obvious differ flavor fractur surfac appear etc accur group well train panel base sensori properti howev differ microbi communiti divers metabolit sdaqu ndaqu still unclear cultur depend method third generat pacif bioscienc pacbio singl molecul real time smrt sequenc technolog nuclear magnet reson nmr combin show characterist microorgan metabolit result show fungal count higher ndaqu rich bacteri communiti higher sdaqu p lentibacillus burkholderia saccharopolyspora thermoascus rasamsonia domin genera sdaqu staphylococcus scopulibacillus chromocleista domin genera ndaqu content differenti acid amino acid alcohol includ fumar glucuron glycin carboxyglutam myo inositol sdaqu higher ndaqu h nmr coupl multivari statist analysi network analysi regard microb metabolit suggest saccharopolyspora show strong posit correl carboxyglutam thermoascus chromocleista high negat correl alanin isobutyr respect linear discrimin analysi lda effect size lefs reveal macrococcus caulobact regard bacteri biomark sdaqu chromocleista key fungal genera ndaqu function predict indic bacteria sdaqu larg involv metabol activ includ biosynthesi degrad detoxif generat precursor metabolit energi

D000434;D064307

T001;T168;T032;T028

compar studi inhibitori effect ferul acid p coumar acid salmonella enteritidi biofilm format biofilm cell exhibit higher resist plankton counterpart common use disinfect food industri phenol acid promis substitut offer less select pressur tradit antibiot studi aim evalu inhibitori effect ferul acid fa p coumar acid p ca salmonella enteritidi biofilm format explor under inhibitori mechan minim inhibitori concentr mic fa p ca mgml respect sub inhibitori concentr mic signific decreas biofilm format without growth inhibitori effect biomass extracellular polymer substanc ep enteritidi biofilm well bacteri swim chemotaxi abil signific decreas expos sub mic concentr fa p ca two phenol acid show high affin protein involv flagella motil repress enteritidi biofilm format relat gene express furthermor two phenol acid maintain high antibiofilm effici simul food process condit studi provid valuabl inform multipl phenotyp molecular respons enteritidi two phenol acid

D003373;D012477

T007;T109;T123

microvirga puerhi sp nov isol puerh tea garden soil strain wgz isol soil sampl puerh tea garden puer citi southwest china isol rod shape gram stain negat facult anaerob non motil growth occur within wv nacl optim concentr ph optim ph c optim temperatur c rrna gene sequenc base phylogenet phylogenom analysi reveal wgz belong genus microvirga major cellular fatti acid c cyclo c c c c andor c c profil polar lipid includ phosphatidyldimethylethanolamin phosphatidylmonomethylethanolamin phosphatidylethanolamin phosphatidylcholin diphosphatidylglycerol phosphatidylglycerol respiratori quinon detect ubiquinon q genom size strain wgz mb content dna g c mol base result digit dna dna hybrid phenotyp result strain wgz could conclud novel speci genus microvirga name microvirga puerhi sp nov propos type strain wgz cgmcc jcm

D041841;D042082

T007

microcyst stromal tumor ovari recurr case somat ctnnb missens mutat microcyst stromal tumor mcsts ovari rare sex cord stromal tumor consid benign neoplasm almost case display unilater local lesion benign outcom except one recurr case famili adenomat polyposi anoth initi metastat case ctnnb mutat report herein sporad case relaps intra abdomin spread year month primari left salpingo oophorectomi torsion ovarian tumor pedicl tumor relaps multipl dissemin subabdomin wall dougla pouch omentum histolog tumor cell form microcyst infiltr surround adipos tissu similar invas implant ovarian epitheli borderlin tumor mutat analysi recurr tumor reveal somat ctnnb psi activ missens mutat germlin kdr pqh variant conclus long term clinic follow may need detect recurr mcst irrespect famili adenomat polyposi

D011125;D010051;D018312

T191;T047

risk diagnosi manag recurr cancer associ thrombosi cat narrat review paper aim provid narrat review risk diagnosi manag recurr venous thromboembol vte cancer patient establish associ cancer vte cancer major risk factor vte histori vte short durat oral anticoagul proxim dvt associ increas risk recurr vte studi shown certain cancer eg metastat genitourinari lung colorect cancer associ recurr vte publish literatur show cancer prothrombot various mechan postul pathway increas thrombogenesi henc recurr vte cancer symptom sign laboratori inform imag result diagnosi recurr vte similar initi vte manag recurr vte involv use low molecular weight heparin lmwh direct oral anticoagul doac vitamin k antagonist vka inferior vena cava ivc filter less common use

D009369;D013927;D054556

T191;T047;T046

cancer relat cognit impair patient newli diagnos aggress lymphoma undergo standard chemotherapi longitudin feasibl studi cancer relat cognit impair crci recognis advers consequ cancer treatment studi assess feasibl collect longitudin data cognit patient newli diagnos aggress lymphoma undergo standard therapi curat intent via self report neuropsycholog assess peripher marker inflamm neuroimag explor descript pattern cancer relat cognit impair cours treatment recoveri also undertaken report separ

D060825;D008228

T191;T048

osapl control nutrient transport system leaf rice oryza sativa l osapl posit control seedl growth grain size rice target plasma membran h atpas encod gene osrha well drastic affect gene encod h coupl secondari activ transport nutrient transport key compon plant growth environment adapt photosynth nutrient produc sourc organ eg leav need transport sink organ eg seed rice unload nutrient occur apoplast transport ie across membran via transport depend effici number transport embed cell membran howev genet mechan under regul transport remain determin show rice oryza sativa l kitaak alter phloem develop osapl homolog myb famili transcript factor promot phloem develop arabidopsi thaliana regul number transport rice overexpress osapl lead increas grain yield head stage osapl act transcript activ osrha encod subunit plasma membran h atpas primari transport addit osapl strong affect express gene encod h coupl secondari activ transport decreas express osapl lead decreas express level nutrient transport gene taken togeth find suggest involv osapl nutrient transport crop yield accumul rice

D017360;D012275

T168;T002

peakforest multi platform digit infrastructur interoper metabolit spectral data metadata manag accuraci featur annot metabolit identif biolog sampl key element metabolom research howev annot process often hamper lack spectral refer data experiment condit well logist difficulti spectral data manag exchang annot laboratori

D055432;D000071253

T091;T170

multipl hypointens vein suscept weight imag promis biomark impair cerebr hemodynam chronic steno occlus diseas multiparametr mri studi patient steno occlus arteri diseas may develop cerebr hypoperfus possibl neurolog sequela aim studi verifi possibl role swi marker cerebr hypoperfus identif patient subgroup signific chronic occlusionsstenos risk critic cerebr hypoperfus

D000081364

T060

natur histori mri brain volum patient neuron ceroid lipofuscinosi sensit imag biomark grey matter gm atrophi due neuron loss strike featur patient cln diseas precis quantit descript diseas progress need order establish evalu tool current futur experiment treatment order develop quantit marker measur brain volum outcom analys longitudin volumetr develop gm white matter wm later ventricl correl clinic cours

D009472

T047

prophylact enoxaparin cathet associ thrombosi postop cardiac children interrupt time seri analysi effect pharmacolog prophylaxi cathet associ thrombosi children unclear evalu complianc outcom associ prophylact enoxaparin protocol postop cardiac children

D062905;D013927;D054556

T046;T047;T074

bioaccumul cd hg muscl juvenil pacif sharpnos shark rhizoprionodon longurio se gulf california studi concentr cd hg measur muscl juvenil individu importan fish ground southeastern gulf california assess health risk human consum consid element level rate shark consumpt nw mexico twenti eight individu sampl septemb quantif hg made cold vapor atom absorpt spectrophotometri analys cd made graphit furnac atom absorpt spectrophotometri general averag hg g g dri weight concentr higher cd comparison result cd hg muscl sever speci genus rhizoprionodon sp report concentr compar maximum permiss limit cd hg g g wet weight fish product human consumpt exceed health risk assess shark consum indic hg concern cd hazard exist

D008628;D012754;D014874

T131;T196;T013

promis approach mitig risk exist tail dam brazil mine oper lead product larg quantiti miner wast fluid fine tail whose dispos rather challeng brazil tail dispos face critic situat due larg accid took place last coupl year respons accid brazilian mine agenc becam stricter licens mine complex issu interrupt activ tail dam paper author propos promis approach minim risk exist tail dam hope industri succeed mine avoid social harm environment damag result present herein show situ electr dewat promis technolog offer mani benefit signific increas solid content liquefi tail stratum within short time lead tail mass possess higher shear strength consequ technolog might well lead safe tail dam brazil bring socio econom environment benefit

D008906

T057

late pulmonari complic relat cancer treatment children number childhood cancer survivor increas heighten awar recognit therapi relat late effect becom import pulmonari complic third lead caus late mortal cancer survivor diagnosi complic chest imag help facilit prompt treatment mitig advers outcom review summar imag late pulmonari complic cancer therapi children highlight characterist find recogn radiologist

D018380;D009369

T191;T061

prognost valu malnutrit evalu use global leadership initi malnutrit criteria associ psoa muscl volum non ischem dilat cardiomyopathi heart failur hf system inflammatori diseas caus hypotrophi skelet muscl loss global leadership initi malnutrit glim criteria develop novel evalu index malnutrit report use hf caus ischem heart diseas howev report use malnutrit evalu glim criteria non ischem dilat cardiomyopathi nidcm relationship psoa muscl volum lack investig prognost valu malnutrit evalu use glim criteria associ psoa muscl volum patient nidcm enrol consecut patient nidcm decemb june malnutrit evalu use glim criteria admiss median follow period year cardiac event defin composit cardiac death hospit worsen hf lethal arrhythmia furthermor measur psoa muscl volum use comput tomographi volumetri patient baselin median age year patient new york heart associ function class ii hf median psoa muscl volum cm total patient malnourish accord glim criteria kaplan meier surviv analysi show malnourish patient cardiac event non malnourish patient log rank p multivari cox proport hazard regress analysi reveal glim criteria base malnutrit independ determin cardiac event hazard ratio confid interv p psoa muscl volum assess total patient lower malnourish non malnourish patient median vs cm p correl bodi mass index r p nutrit screen use glim criteria may use predict futur cardiac event patient nidcm reflect potenti relationship malnutrit low psoa muscl volum

D002311;D044342;D009202;D006333

T047;T046

acut chang passiv stiff individu hamstr muscl induc resist exercis effect contract mode rang motion recent studi rais interest possibl resist exercis also decreas passiv muscl stiff stretch exercis howev littl known program variabl resist exercis acut influenc muscl stiff aim examin acut chang passiv stiff individu hamstr muscl resist exercis use differ combin contract mode rang motion rom

D054459;D000070633;D055070

T061;T023;T060

immun relat gtpase irgm intersect autophagi inflamm tumorigenesi human immun relat gtpase irgm gtp bind protein regul select autophagi includ xenophagi mitophagi irgm impact autophagi affect mitochondri fusion fission promot co assembl ulk beclin enhanc beclin interact partner ambra atgl uvrag interact key protein atgl p nod cgas tlr rig regul lysosom biogenesi irgm also negat regul nlrp inflammasom format therefor matur import pro inflammatori cytokin il impact inflamm pyroptosi ultim afford protect chronic inflammatori diseas import ten irgm polymorph rs rs rs rs rs rs rs rs rs rs associ human inflammatori disord includ cancer suggest genet variant function relev autophag inflammatori respons current review contextu irgm modul autophagi inflamm emphas role irgm cross point immun tumorigenesi

D019204;D020022

T126;T116;T032

develop modifi microdosimetr kinet model relat biolog effect proton therapi predict biolog effect ionis radiat quantiti biolog dose introduc instead physic absorb dose proton therapi constant relat biolog effect rbe usual appli clinic recommend intern commiss radiat unit measur studi present new model base modifi microdosimetr kinet model mmkm calcul variabl rbe valu base experiment data induct dna doubl strand break dsbs within cell mmkm propos base experiment data yield dsbs mammalian cell allow modif yield primari lesion mkm approach uniqu function name f let describ relat rbe linear energi transfer let consid charg particl present model dmmkm mmkm approach develop consid differ f let differ relev ion involv energi deposit event proton therapi although experiment data repres depend yield primari lesion ion speci dsb yield assum main primari lesion assum independ ion speci mmkm dmmkm consid yield primari lesion function ion speci valu better agreement experiment data compar mkm mmkm approach biolog dose dmmkm predict lower mmkm propos model variat paramet higher constant valu assum mkm distal end spread bragg peak sobp moreov level cell death estim mmkm sobp region higher obtain base dmmkm conclud consid modifi f let model develop consist experiment result mmkm mkm approach consid dmmkm examin biolog effect full detail therefor effect improv proton therapi

D061766

T061

antitumor effect polyphyllin liver metastas neuroblastoma previous report polyphyllin main compon tradit chines medicin herb pari polyphylla exhibit anticanc effect vitro human neuroblastoma cell aim investig examin presenc absenc vivo anti metastasi effect polyphyllin establish liver metastasi model neuroblastoma evalu anti metastasi effect polyphyllin

D004144;D008113;D009447

T191;T109;T123

manag acut coronari syndrom without st segment elev collect term acut coronari syndrom ac encompass st segment elev myocardi infarct stemi non st segment elev ac nste ac latter compris unstabl angina pectori non st segment elev myocardi infarct nstemi diagnosi stemi necessit immedi referr cardiac catheter diagnost manag nste ac challeng current guidelin european societi cardiolog esc treatment nste ac publish deal topic diagnost risk stratif antithrombot treatment invas non invas coronari diagnost long term treatment focus guidelin applic high sensit cardiac troponin assay hs ctn combin verifi diagnost algorithm enabl rapid triag decis rule possibl nstemi rule nstemi exclud emerg room chest pain unit

D054058;D000072658;D000072657

T047

inhibit irak allevi coliti inhibit tlr nf b pathway protect intestin barrier interleukin receptor associ kinas irak main kinas toll like receptor tlr mediat pathway consid new target treat inflammatori diseas studi show signific correl tlrs inflammatori respons ulcer coliti uc therefor studi induc experiment coliti mice dextran sulfat sodium dss differ concentr irak inhibitor administ intraperiton diseas activ index assess includ degre patholog damag stain subsequ western blot detect tlrnf b pathway intestin barrier protein express zonula occludin claudin jam real time polymeras chain reaction rt pcr detect mrna express level irak mucin furthermor express level zonula occludin detect immunofluoresc includ plasma fitc dextran concentr evalu intestin barrier permeabl howev elisa measur express inflammatori factor reflect intestin inflamm mice investig show irak inhibitor signific reduc clinic symptom patholog dss induc coliti damag mice inhibit cytoplasm nuclear transloc nf b p includ phosphoryl ib reduct downstream inflammatori factor product therefor establish irak inhibitor effect improv coliti induc dss part inhibit tlrnf b pathway reduc inflamm maintain integr colon barrier

D003092;D003093

T047

tissu distribut mercuri bodi wild american allig allig mississippiensi coastal marsh louisiana usa total mercuri thg concentr measur wild allig inhabit coastal marsh southern louisiana determin tissu distribut thg among various bodi organ tissu compart concentr thg claw dermal tail scute compar blood brain gonad heart kidney liver skelet muscl determin former tissu common avail non lethal sampl could use measur bodi burden various intern organ mercuri found bodi organ tissu compart howev overal thg concentr measur allig fda action level fish consumpt compar previous data report southwestern louisiana result suggest consumpt meat allig found region may littl public health concern howev extend period time sampl studi present day highlight need continu addit recent sampl ensur consum safeti total mercuri concentr highest kidney mgkg dw liver mgkg dw thg level non lethal sampl blood claw dermal tail scute posit correl tissu thg concentr blood r claw r scute r thg concentr blood claw scute correl intern organ non lethal sampl method may viabl method estim level thg bodi tissu

D000489;D008628;D014874

T131;T196;T014

decis make improv health relat qualiti life patient kidney stone compar surgeri versus observ use mix method analysi experi patient choos observ surgeri kidney stone well establish compar patient use qualit interview wisconsin qualiti life questionnair wisqol cambridg renal stone patient report outcom measur cresp adult patient upper tract urinari calculi observ intervent option underw qualit interview baselin month wisqol cresp administ baselin week post oper surgeri select comparison patient experi qualiti life measur perform group among patient opt surgeri patient opt observ identifi major theme patient experi relat context health care episod patient respons perceiv outcom conceptu framework domain patient experi kidney stone diseas develop use clinician patient shape discuss baselin standard wisqol cresp score compar group surgeri group wisqol cresp score improv surgeri wisqol higher better p cresp lower better p patient underw surgeri kidney stone report improv qualiti life treatment via wisqol cresp conceptu framework develop patient experi kidney stone provid common languag patient clinician

D007669;D014545

T047;T031

hip fractur oper compar death two year elder patient lowest risk revis dual mobil total hip arthroplasti bipolar hemiarthroplasti intern fixat garden ii studi determin two year follow lifetim risk oper elder patient hip fractur undergo intern fixat dual mobil total hip arthroplasti bipolar hemiarthroplasti use death patient compet risk

D019644;D005265;D062785

T061;T037

effect proxim fibular partial excis medial compart knee osteoarthr studi aim investig clinic radiolog progress patient underw proxim fibular partial excis pfpe medial compart knee osteoarthr

D020370

T047

continu dopaminerg stimul counteract l dopa induc overact ca ohda lesion rat clinic treatment parkinson diseas pd emerg l dopa induc dyskinesia lid motor symptom remain restrict factor use levodopa l dopa object test effect continu dopaminerg stimul cds lid mechan effect calcium ca signal pathway ohda hydroxydopamin treat rat administ cmc na l dopa rotigotin behen rgtb l dopa rgtb respect day treatment abnorm involuntari movement aim score conduct day first dose subsequ number tyrosin hydroxylas th posit neuron detect immunohistochemistri addit chang ca detect use laser confoc techniqu relat protein neuron nos nnos bax bcl camkii p camkii psd measur western blot transmiss electron microscopi tem use investig chang synapt structur data show cds reduc aim score increas express th substantia nigra sn decreas express nnos baxbclratio striatum reduc ca influx induc l dopa inhibit ca signal pathway dopamin neuron striatum moreov overact synaps induc l dopa inhibit cds data support hypothesi continu deliveri dopamin agonist reduc risk lid induct moreov rgtb could promis treatment pd simul cds

D004409;D010300

T047

explor effect famili base intervent psychosi low middl incom countri systemat review peopl psychosi live low middl incom countri lmic left care famili world health organ recommend inclus famili communiti base rehabilit evid implement lmic review yet studi aim describ key featur implement strategi famili base intervent lmic apprais effect

D003906;D011618

T048;T080

meta qtls multipl diseas resist involv three rust common wheat triticum aestivum l wheat multipl diseas resist meta qtls mdr mqtls under candid gene three rust identifi may prove use develop resist cultivar rust diseas wheat major threat global food secur therefor develop multipl diseas resist cultivar resist three rust major goal wheat breed program worldwid present studi meta qtls candid gene multipl diseas resist mdr involv three rust identifi use individu qtl map studi resist leaf rust lr stem rust sr yellow rust yr studi total qtls resist three rust retriev includ qtls lr qtls sr qtls yr qtls qtls could project onto consensus map satur marker meta analysi project qtls result identif mqtls includ mdr mqtls ten mdr mqtls refer breeder mqtls seventi eight mqtls could also anchor physic map wheat genom mqtls valid marker trait associ identifi earlier genom wide associ studi twenti mqtls includ mdr mqtls identifi present studi co local known r gene silico express analysi allow identif sever differenti express candid gene decg encod protein carri differ domain includ follow nbs lrr wrki domain f box domain sugar transport transferas etc introgress mdr loci high yield cultivar prove use develop high yield cultivar resist three rust

D001487;D060467

T040;T004

uncertainti estim strategi quantit non target analysi non target analysi nta method wide use chemic discoveri seldom employ quantit due lack robust method estim chemic concentr confid limit herein present evalu new statist method quantit nta qnta use high resolut mass spectrometri hrms data epa non target analysi collabor trial entact experiment intens entact analyt observ multipl concentr use semi autom nta workflow chemic concentr correspond confid limit first estim use tradit calibr curv two qnta estim method implement use experiment respons factor rf data rf intensityconcentr bound respons factor method use non parametr bootstrap procedur estim select quantil train set rf distribut quantil estim appli test set hrms intens invers estim concentr confid limit ionize effici estim method restrict distribut like rfs analyt use ionize effici predict given intend futur use chemic risk character predict upper confid limit protect valu compar known chemic concentr use tradit calibr curv upper confid limit within tenfold true concentr error increas fold esi fold esi ionize effici estim method fold esi fold esi bound respons factor method work demonstr success implement confid limit estim strategi support qnta studi mark crucial step toward translat nta data risk base context

D035501

T033

ecolog sustain assess water distribut mainten ecosystem servic biodivers water provis distribut subject conflict user worldwid agricultur major driver discord water sensit ecosystem servic often impair man made water shortag nevertheless suffici includ sustain risk assess neglect come distribut avail water resourc herein present contribut sustain develop goal clean water sanit sdg life land sdg ecolog sustain assess water distribut esaw tool esaw tool introduc watersh sustain assess evalu sustain water suppli demand ratio basin level domest water use water requir ecosystem consid import water user ecolog risk assess estim potenti impact agricultur deplet renew water resourc ground water depend ecosystem esaw tool work standard gis applic applic basin worldwid set broad avail input data esaw tool test danub river basin combin high resolut hydro agroecolog model data hydrolog land surfac process model promet groundwat model opengeosi freeli avail data water use biodivers wetland map base result measur sustain water manag deduc increas rainf agricultur near vulner ecosystem chang certain crop tool support decis make author local nation level well privat enterpris want improv sustain suppli chain

D003247;D017753

T064;T081;T082;T069;T078;T070

protocol random multipl center trial conserv versus liber oxygen target critic ill children oxi picu oxygen pediatr intens care oxygen administr fundament part pediatr critic care supplement oxygen offer near everi acut unwel child howev optim target system oxygen unknown oxi picu aim evalu clinic effect cost effect conserv peripher oxygen satur sp target compar liber target

D016638;D010100

T121;T047;T123;T196

uniqu pool carbohydr degrad enzym novel bacteria assembl cow buffalo rumen metagenom reconstruct genom environment metagenom offer excel prospect studi metabol potenti organ resili isol laboratori condit assembl high qualiti metagenom assembl genom mag estim complet cow buffalo rumen metagenom averag nucleotid ident ani score base screen exist databas suggest novelti genom gene predict led identif protein encod gene peg across genom annot specif function attribut analysi reveal presenc carbohydr activ enzym cazym glycosid hydrolas famili proper match cazi databas genom mine reveal presenc high frequenc plant biomass deconstruct gene bacteroidet mag compar firmicut result strong indic rumen chamber harbor high number deepli branch yet uncultur microb encod novel cazym candid prospect usag plant biomass hydrolyz biofuel industri key point genom bin play crucial role reveal metabol potenti uncultiv microb assembl novel genom cow buffalo rumen metagenom dataset high frequenc plant biomass deconstruct gene identifi bacteroidet mag

D054892;D012417

T023;T028

design character novel lytic protein clostridium difficil clostridium difficil c difficil gram posit spore form toxin produc anaerob caus nosocomi antibiot associ intestin diseas autolysin lytic enzym hydrolyz peptidoglycan bacteri cell wall catalyt domain cell wall bind domain proven involv bacteri cell wall remodel cell divis although autolysin c difficil report autolysin fail yield impress result use exogen lytic agent studi express character bind domain cwp bd acd bd catalyt domain cwp cd acd cd cwl cd c difficil autolysin domain best bind specif lytic activ select toward c difficil design novel lytic protein cwl cwb cwl cwb show good biosafeti signific low hemolysi without cytotox result fluoresc analysi lytic assay demonstr cwl cwb higher bind specif stronger lytic activ minimum inhibitori concentr gml live c difficil cell signific stronger commerci lysozym gml report c difficil autolysin besid cwl cwb exhibit good stabil lytic activ still retain incub c h consid potenti antimicrobi agent combat c difficil key point sever bind domain catalyt domain deriv sever clostridium difficil autolysin express purifi function character novel c difficil lytic protein cwl cwb design c difficil autolysin bind specif lytic activ cwl cwb c difficil show advantag compar report c difficil autolysin cwl cwb exhibit signific low hemolysi cytotox normal deriv colon mucosa cell

D016360

T007

emot qualiti earli educ program improv languag learn within child across context design observ studi compar child outcom earli care educ classroom differ qualiti often confound child differ within child design track children across context identifi effect qualiti less confound analysi australian children n mean age year femal indigen ethnic data unavail track across pre k k year conduct assess chang observ qualiti classroom assess score system associ chang cognit develop woodcock johnson iii threshold qualiti also investig increas emot support associ improv languag develop ci approxim week develop result highlight emot qualiti integr potent compon earli learn

D007858;D004644

T061;T041;T062

asymmetr synthesi cyclopenten compound contain carbon quaternari stereocent cycloaddit applic formal synthesi r puraquinon acid high stereoselect cycloaddit asymmetr synthesi versatil cyclopenten compound contain carbon quaternari stereocent develop phosphin catalyz reaction alkyno alkyl electron defici alken bear oppolz camphorsultam show high excel diastereoselect perfect regioselect use reaction demonstr concis formal synthesi r puraquinon acid

D002244;D003517

T121;T109;T196

nicotinamid mononucleotid administr restor redox homeostasi via sirt nrf axi protect age mice oxid stress induc liver injuri alter adapt homeostasi contribut age lifespan regul present studi character mechan age mous liver perform quantit proteom found upregul protein relat oxid reduct process analysi reveal malondialdehyd mda protein carbonyl pco level increas nuclear nrf downstream gene signific increas indic oxid stress induc nrf activ age mous liver import nicotinamid mononucleotid nmn administr decreas oxid stress nuclear nrf nrf downstream gene level inde age mice treat nmn improv stress resist acetaminophen apap induc liver injuri indic nmn restor nrf mediat adapt homeostasi studi found nmn increas sirt activ deacetyl age associ acetyl k k sod effect nuclear nrf level diminish sirt defici mice suggest nmn enhanc adapt homeostasi sirt depend taken togeth demonstr nrf regul adapt homeostasi decreas age mous liver nmn supplement restor liver redox homeostasi via sirt nrf axi protect age liver oxid stress induc injuri

D056487;D056566

T047;T126;T116

tuberindin truffl alkaloid unpreced skeleton exhibit anti hyperuricem bioactiv tuberindin b truffl alkaloid intrigu structur isol tuber indicum detect truffl speci appear aris biosynthet amino acid isosaccharin unit compound upregul express organ anion transport oat abcg signific exhibit antihyperuricem bioactiv vitro vivo might support valu truffl dietari supplement

D000470

T121;T131;T109;T123

intermedi term outcom total endoscop atrial septal defect repair beat heart small children object manipul narrow surgic field risk femor arteri fa complic difficulti appli total endoscop surgeri tes congenit heart diseas small children studi conduct investig feasibl tes atrial septal defect asd repair children weigh kg method juli juli patient mean age year mean weight kg rang kg underw tes asd repair beat heart fa cannul establish dacron graft addit fa cannula fr smaller expect size place left fa case increas arteri pressur three mm trocar one mm port use surgic field fill co aortic clamp aortic root needl snare inferior vena cava use mean follow time month result cardiopulmonari bypass cpb instal time cpb time oper time min min min respect total drainag volum ml patient need analges day surgeri sever complic includ arteri complic record follow conclus optim surgic field set fa cannula correct tes asd closur feasibl small children weigh kg

D006330;D006344

T019

chest wall reconstruct print anatom function consider larg chest wall defect result wide local excis chest wall patholog requir skelet soft tissu reconstruct restor anatom shape structur respiratori function thorax reconstruct challeng requir surgic reconstruct team understand anatom physiolog morbid relat defect choic reconstruct techniqu avail restor form function rapid emerg dimension print technolog allow reconstruct surgic team custom therapeut process skelet reconstruct accur mimick shape structur chest wall replac integr knowledg anatomi physiolog mechan breath respiratori test import restor form function focus articl review anatomi physiolog assess respiratori function classic textbook integr knowledg precis anatomi chest wall creat print technolog articl demonstr print may help reconstruct team understand anatom physiolog morbid relat chest wall defect import take aspect consider undertak chest wall reconstruct thorax

D019651;D035441

T061;T023

redirect persist left superior vena cava use turn left atrial appendag persist left superior cava most drain right atrium via coronari sinus rare drain left atrium extracardiac intracardiac repair techniqu describ repair persist left superior vena cava drain left atrium herein report success applic new intracardiac repair techniqu use turn left atrial appendag year old male patient persist left superior vena cava drain left atrium

D020517;D006344;D000083402

T023;T019

associ screen digit breast tomosynthesi vs digit mammographi risk interv invas advanc breast cancer digit breast tomosynthesi dbt develop expect improv cancer detect women dens breast studi need evalu interv invas advanc breast cancer rate intermediari outcom relat breast cancer mortal breast densiti breast cancer risk

D001940;D001943;D055088;D008327;D008403

T191;T023;T058;T060

effect vareniclin ad counsel smoke cessat among african american daili smoker kick swope iv random clinic trial african american smoker among highest rate tobacco attribut morbid mortal us effect treatment need smoke level

D001741;D003376;D016540;D000077444;D000068580

T058;T098;T055;T121;T109

patient acut infecti conjunct bacteri infect ration clinic examin systemat review acut infecti conjunct character ocular red discharg common clinic entiti evid base tool aid clinic diagnosi viral vs bacteri conjunct lack may contribut overprescrib topic antibiot

D003234;D003236

T047

find valenc antibond level avoid rydberg pseudo continuum dipol bound orbit electron structur method wide use assist interpret mani varieti experiment data energi physic characterist eg size shape spatial local valenc antibond orbit play key role varieti chemic process includ photochem reaction electron attach reduct use woodward hoffmann type analys probe reaction energi barrier energi surfac intersect lead intern convers intersystem cross one abil proper popul valenc antibond orbit within electron structur calcul often hinder presenc molecular orbit similar energi intrud orbit rydberg pseudo continuum dipol bound characterist articl show within wide avail electron structur code one avoid pitfal present intrud orbit proper popul valenc orbit subsequ use orbit calcul includ electron correl effect therebi offer possibl chemic use precis special emphasi given case electron state metast

D004583

T196;T081

guid membran atgyl autophagi reflect immun process membran atgyl defin herein conjug atg famili ubiquitin like protein membran lipid begin appreci broader manifest mechan function classic membran atgyl lcb one six mammalian atg famili protein view hallmark canon autophagi entail format characterist doubl membran cytoplasm howev atg well describ conjug singl membran recent protein propos atgyl coopt multipl downstream process one canon autophagi elabor biolog output impact metabol qualiti control immun emphas context inflamm immunolog effect conclus propos atgyl modif akin ubiquityl util differ system particip membran stress respons membran remodel activ encompass autophagi beyond

D001343;D014452

T043;T123;T116

general design strategi anti aromat porphyrinoid systemat investig arrang typic anti aromat porphyrinoid sequenc perform base densiti function theori calcul six rule summar obtain high perform anti aromat porphyrinoid two atom deletedad electron current ring flow pipe immedi obtain electron anti aromat system good idea increas number pyrrolethiophenfuran unit electron current ring flow pipe heteroatom select order optim choic nh second choic last choic worth note c cc c unit benefici anti aromat properti signific avoid crowd environ core space anti aromat molecul view much better nh circular skeleton much better ellips like rectangular parallelogram like one

D011166

T109;T123

clinic featur pancreat neuroendocrin microadenoma singl center experi literatur review pancreat neuroendocrin microadenoma nema nonfunct neuroendocrin tumor less mm studi nema base autopsi report reveal clinic frequenc nema investig clinicopatholog featur nema

D018761;D018358;D010190

T191

real world util delphi consensus diagnost criteria suspect pyoderma gangrenosum found systemat use delphi consensus diagnost criteria result substanti chang manag pattern case suspect pyoderma gangrenosum pg includ reduct system corticosteroid use signific improv clinic outcom improv may result combin reduc misdiagnosi optim manag reduc iatrogen harm increas util valid diagnost criteria pg could optim provid heurist increas diagnost accuraci optim manag clinic outcom

D017511

T047

tribal makeup paint mimick achrom lupus teke tribal chef icono diagnosi danger art close photograph teke communiti chief congo circa seem diagnost interest area achrom macula visibl hand relev diagnos koebner phenomenon background vitiligo diagnosi lupus howev examin entir photograph show macula fact tribal makeup show methodolog limit icono diagnosi

D014820;D017496

T047

janus kinas inhibitor treatment improv subcutan pulmonari sarcoidosi patient glaucoma first case provid signific evid jak inhibitor effect treatment subcutan pulmonari sarcoidosi also first case tofacitinib use patient contraind corticosteroid therapi

D005901;D000075242;D017565

T121;T047

dose reduct imag qualiti photon count detector high resolut comput tomographi chest routin clinic data photon count detector comput tomographi pcd ct potenti signific improv ct imag mani way includ limit low dose high resolut ct hrct lung aim studi perform intrapati comparison radiat dose imag qualiti pcd ct compar convent energi integr detector ct eid ct

D000084862;D017785

T061;T167

macrophag nlrp activ promot right ventricl failur pulmonari arteri hypertens rational pulmonari arteri hypertens pah often result death right ventricular failur rvf nlrp nucleotid bind domain leucin rich contain famili pyrin domain contain macrophag activ may promot rvf pah object evalu contribut nlrp inflammasom rv macrophag pah rvf method rat decompens rv hypertrophi monocrotalin mct sugen hypoxia suhx compar compens rv hypertrophi rat pulmonari arteri band echocardiographi right heart catheter perform macrophag atrial natriuret peptid fibrosi evalu microscopi flow cytometri nlrp inflammasom activ cardiotox confirm immunoblot vitro strategi mct rat treat sc gp antagonist mcc nlrp inhibitor macrophag nlrp activ evalu patient pah rvf measur main result macrophag fibrosi atrial natriuret peptid increas mct suhx rvs left ventricl pulmonari arteri band rat although mct rv macrophag inflammatori lung macrophag antiinflammatori ccr macrophag monocyt deriv increas mct suhx rvs high express nlrp macrophag nlrp pathway upregul patient pah decompens rvs cultur mct monocyt show nlrp activ cocultur experi result cardiomyocyt mitochondri damag mcc prevent vivo mcc reduc nlrp activ regress pulmonari vascular diseas rvf sc reduc rv macrophag nlrp content prevent stat signal transduc activ transcript activ improv rv function without regress pulmonari vascular diseas conclus nlrp macrophag activ occur decompens rv preclin pah model patient pah inhibit gp nlrp signal improv rv function concept pah rvf result rv inflamm rather sole elev rv afterload suggest new therapeut paradigm

D006333;D006976;D000081029;D018497

T047;T046

clinician prefer neurotechnolog pediatr drug resist epilepsi discret choic experi novel minim invas neurotechnolog offer potenti reduc burden epilepsi avoid risk convent resect surgeri neurotechnolog test random control trial pediatr popul leav clinician face decis whether recommend treatment insuffici evid relev risk benefit studi specif explor prefer clinician treat pediatr drug resist epilepsi dre novel neurotechnolog

D000069279;D004827;D055536

T061;T047;T033

effect person protect equip don dof program nurs militari hospit studi aim develop verifi effect new person protect equip don dof program nurs militari hospit total nurs experiment group control group particip nonequival control group experiment studi new program consist descript design modif inner outer boundari mark coveral video verbal instruct footswitch particip could watch pace data collect carri immedi week intervent effect program accuraci self efficaci time analyz use general estim equat ppe don dof accuraci self efficaci time signific increas experiment group compar control group immedi week intervent program confirm effect improv ppe don dof accuraci self efficaci recommend use program train nurs don dof ppe

D006772;D000067393

T093;T073

magnet reson imag assess right ventricular deform patient transposit great arteri detect chang right ventricular rv myocardi deform patient system rv srv transposit great arteri tga compar individu without structur heart diseas

D014188;D018497

T046;T019

prehospit care coronari arteri diseas major risk factor geropsychiatr inpati older adult serious mental ill high preval coronari arteri diseas major risk factor arteri hypertens dyslipidemia diabet mellitus preval clinic control condit compar geropsychiatr inpati dementia versus mood psychot disord

D003324;D003704;D004632;D006973

T047;T093;T061;T058;T048

cyclic disulfid liposom membran function cellular deliveri liposom effect therapeut deliveri nanocarri due abil encapsul enhanc pharmacokinet properti wide rang therapeut two primari area improv need liposom drug deliveri enhanc abil infiltr cell facilit derivat liposom surfac herein report liposom platform incorpor cyclic disulfid lipid cdl dual purpos enhanc cell entri function liposom membran thiol disulfid exchang order accomplish cdl cdl compos lipoic acid la asparagus acid aa append lipid scaffold design synthes fluoresc base micropl immobil assay implement show compound enabl conveni membran decor reaction thiol function small molecul addit fluoresc microscopi experi indic dramat enhanc cellular deliveri cdls incorpor within liposom result demonstr multifunct cdls serv excit liposom system surfac decor enhanc cellular deliveri

D016503;D008081

T074;T109

hkme play key role establish permiss chromatin state bud dormanc bud break appl bud dormanc help woodi perenni surviv winter activ robust plant develop spring appl malus domestica short term chill induc bud dormanc autumn prolong chill lead dormanc releas shift quiescent state winter subsequ warm period promot bud break spring epigenet regul contribut season respons vernal howev histon modif integr season cue intern signal bud dormanc woodi perenni remain larg unknown show hkme play key role establish permiss chromatin state bud dormanc bud break appl global chang gene express strong correl chang hkme hkme high express dormanc associ mad box dam gene key regul dormanc autumn associ high hkme level addit known damshort veget phase svp target gene signific overlap hkme modifi gene bud dormanc progress data suggest hkme contribut central dormanc circuit consist damsvp abscis acid aba autumn winter lower express hkme level dam gibberellin metabol gene control chill induc releas dormanc warm condit spring facilit express gene relat phytohormon cell cycl cell wall modif increas hkme toward bud break studi also reveal activ auxin repress aba sensit spring condit least part temperatur mediat epigenet regul winter

D027845

T168;T002

impact molar incisor hypominer oral hygien gingiv health year old children studi aim evalu impact molar incisor hypominer mih oral hygien gingiv health investig relationship factor sever mih

D009910;D003744

T055;T047

advanc practic role delin within hong kong cross section studi career ladder nurs includ sever level nurs practic specif role advanc practic nurs introduc hong kong around start st centuri date studi distinguish practic advanc practic nurs hong kong cross section studi conduct novemb march aim identifi differenti practic pattern advanc practic nurs util advanc practic role delin tool total respons obtain three role identifi nurs consult advanc practic nurs advanc practic nurs manag among five advanc practic nurs domain nurs frequent involv educ direct comprehens care activ least activ research public profession leadership identifi activ various nurs role help differenti respons provid new insight role util support although role characterist shape countri context research evid practic pattern may use support intern discuss effort promot role clariti effect role introduct optim

D057179

T091

potenti use microwav technolog dermatolog microwav use medicin diagnost treatment cancer recent novel microwav devic swift emblat ltd uk miradri miramar lab inc ca clear fda health canada various dermatolog condit

D017497;D055623;D002145;D003880;D006945;D014860;D013543

T047;T020;T191;T091;T033

associ plasma vitamin b level caus mortal nest case control studi aim evalu prospect associ vitamin b caus mortal explor potenti modifi chines adult hypertens nest case control studi conduct china stroke primari prevent trial includ death caus match control median follow durat year primari outcom measur investig caus mortal encompass death reason mean plasma vitamin b concentr case ngml higher control ngml p vitamin b assess quintil compar refer group q ngml risk caus mortal increas ci q ci q ci q ci q trend test signific p q q combin signific increment ci caus death risk found compar q q advers effect pronounc normal folat level p interact older peopl p interact studi suggest higher baselin level plasma vitamin b risk factor caus mortal among chines patient hypertens especi among older adult adequ folat level find confirm may inform novel clinic nutrit guidelin intervent optim vitamin b level

D006973

T047

evalu combin use phenytoin cream fraction co laser treatment stabl nonsegment vitiligo pilot studi vitiligo autoimmun disord melanocyt character macular depig patch sever treatment modal diseas includ use corticosteroid calcineurin inhibitor vitamin analog topic phenytoin combin therapi util fraction co laser differ topic agent use enhanc treatment respons promis result studi aim evalu effect fraction co laser combin topic phenytoin studi patient femal male age mean age nonsegment stabl vitiligo recruit insuffici respons least year treatment monotherapi use topic corticosteroid calcineurin inhibitor andor nb uvb phototherapi patient treat combin fraction co laser nm puls energi mj mixel south korea rate vac hz month interv six session applic phenytoin cream twice daili photographi done treatment wood lamp sever diseas use vasi score calcul compar treatment mean vasi score treatment sixth month treatment increas p valu patient divid three group base vitiligo subtyp acral upper extrem trunk vasi score measur group vasi score treatment acral area upper extrem trunk respect studi reveal combin therapi phenytoin fraction co laser effect treatment vitiligo upper extrem trunk also interest acral area

D054020;D014467;D014820

T061;T047;T074;T073

dimer fe iii bpi aqueous solut elucid mechan base histor propos electrochem data comput free energi analysi iron ii tris bipyridin fe ii bpi histor signific organometal coordin complex attract redox photophys properti respect energi storag low cost high redox potenti complex thus attract use catholyt aqueous redox flow batteri despit favor characterist oxid fe iii form undergo dimer form fe iii bpi h lead dramat v decreas batteri discharg date energet complet mechan slow sequenti electrochem chemic ec process includ electron transfer nucleophil attack ligand cleavag oxo bond format spin state transit elucid use cyclic voltammetri redox flow batteri data densiti function theori calcul guid previous propos mechan model complex perform geometri scan resolv key step dictat complex chemic process quantit free energi surfac develop model mechan dimer account spin ident possibl fe ii fe iii fe iv intermedi electrochem reduct dimer regener fe ii bpi overal revers process comput electrochemistri interrog influenc spin state coordin environ molecular conform electrod electrolyt interfac propos stepwis dimer reduct process experiment show consider overpotenti associ event catalyt mitig dispar materi includ platinum copper hexacyanoferr activ carbon find fundament appli signific could elev fe ii bpi deriv play vital role burgeon renew energi economi

D005290;D014867

T121;T104;T197

cm scorpion toxin uniqu primari structur inhibit kv kv high affin cm venom centruroid margaritatus short peptid consist amino acid residu mol wt cm kd valu kv inhibit kv kv kca kca k channel nav nav na channel hhv h channel block kv current biolog function assay cm strong inhibit express activ marker interleukin receptor cd ligand anti cd activ human cd effector memori lymphocyt cm due uniqu structur may serv templat generat novel peptid target kv autoimmun diseas

D012604

T131;T123;T116

associ socioeconom status nonsuicid self injuri suicid ideat young korean adult although nonsuicid self injuri nssi youth import mental health concern worldwid limit studi investig sociodemograph correl earli adulthood studi explor associ socioeconom status ses self harm behavior includ nssi suicid ideat communiti base sampl young adult

D016728;D059020

T055;T033

target procalcitonin protect vascular barrier integr rational capillari leakag frequent occur sepsi major surgeri associ microvascular dysfunct advers outcom procalcitonin well establish biomark inflamm without known impact vascular integr object determin procalcitonin induc endotheli hyperperm target procalcitonin protect vascular barrier integr method prospect observ clinic studi procalcitonin level assess patient underw cardiac surgeri correl postop fluid vasopressor requir along sublingu microvascular function effect procalcitonin signal pathway endotheli barrier adheren junction integr character vitro verifi mice inhibit procalcitonin activ dipeptidyl peptidas dpp evalu murin polymicrobi sepsi clinic verifi cardiac surgeri patient chronic take dpp inhibitor sitagliptin measur main result elev postop procalcitonin level identifi patient fold increas fluid requir p fold higher vasopressor demand p compromis microcircul reduct perfus vessel p procalcitonin induc fold endotheli fold pulmonari capillari permeabl p destabil cadherin procalcitonin effect depend activ dpp target procalcitonin receptor dpp sepsi induc hyperprocalcitonemia reduc capillari leakag p respect sitagliptin cardiac surgeri associ augment microcircul vs perfus vessel non sitagliptin medic patient p fold decreas fluid p fold reduc vasopressor demand postop p conclus target procalcitonin action endothelium feasibl mean preserv vascular integr system inflamm associ hyperprocalcitonemia

D018819;D018805

T047;T046;T116;T126;T129

biominer inspir colloid liquid crystal assembl hybrid compris inorgan nanocryst organ polym compon function bioinspir organicinorgan synthet composit studi high perform function materi natur biominer pearl teeth bone self organ organicinorgan composit inorgan compon compos calcium carbon caco hydroxyapatit hap organ compon consist peptid polysaccharid composit use structur materi hard biolog tissu biominer show signific higher perform synthet composit glass fiber carbon fiber reinforc plastic howev biominer consist environment friend biocompat compon prepar mild condit moreov form elabor nanostructur self organ hierarch structur much learn materi design biominer base hierarch nanostructur composit assist prepar function materialsinspir biolog hard tissu develop nanostructur thin film bulk hybrid crystal self organ organ polym inorgan crystal caco hap biominer combin insolubl compon solubl acid macromolecul control crystal process shown poli acryl acid paa acid peptid call polym addit induc format thin film crystal caco hap cooper insolubl organ templat chitin synthet polym bear oh group moreov recent develop caco hap base nanostructur particl rod disk shape obtain aqueous media use macromolecular acid addit paa without use insolubl polym templat appropri concentr anisotrop particl self assembl form colloid liquid crystallin lc phaseslc materi general compos organ molecul show order mobil state addit stimuli respons properti organ rod like lc molecul led success develop inform display wide use hand colloid liquid crystal colloid self assembl dispers anisotrop organ inorgan nano micro object exampl polysaccharid whisker clay nanosheet gibbsit plate shape particl silica rod shape particl exhibit colloid lc statesin account focus materi design hierarch aspect biominer base colloid lc polymerinorgan composit describ design prepar nanostructur self assembl behavior new bioinspir biocompat self organ materi character result self assembl nanostructur colloid liquid crystal found use high resolut transmiss electron microscopi small angl x ray scatter neutron scatter rheolog measur also report function biominer inspir liquid crystal present biominer base lc colloid liquid crystal prepar mild aqueous condit consist environment friend biocompat compon new function expect materi

D050866;D053758

T104;T073

probiot potenti gaba produc lactobacilli isol uruguayan artisan chees starter cultur studi sought identifi character collect lactobacilli strain isol natur whey starter use uruguayan artisan chees product base capac produc gamma aminobutyr acid gaba probiot potenti

D002611;D019936

T007;T168

arabidopsi abcg play essenti role flower leaf develop modul abscis acid content abscis acid aba phytohormon mediat stress respons regul plant develop sever atp bind cassett abc transport g subfamili abc abcg protein report transport aba investig whether abcg protein mediat plant development process regul aba arabidopsi arabidopsi thaliana abcg gene upregul respons exogen aba treatment abcg knockout mutant exhibit two development defect epinast leav abnorm long pistil reduc fertil siliqu length abcg express induc threefold flower bud expos exogen aba promot abcg two aba respons element aba content pistil true leav increas abcg knockout mutant detach abcg pistil expos exogen aba grew longer wild type control abcg fuse gfp local plasma membran express arabidopsi mesophyl protoplast transcriptom analysi pistil true leav wild type abcg knockout mutant reveal express organ develop relat gene chang knockout mutant particular express tran act small interfer ta si rna process enzym gene regul flower leaf develop low knockout mutant togeth result suggest abcg like function aba transport plasma membran modul aba level therebi regul develop pistil leav normal non stress condit

D017360;D029681

T116;T002

develop diagnost criteria skin diseas map evid breadth scope dermatolog diagnost criteria current unknown creat map diagnost criteria provid panoram view past ongo research develop dermatolog diagnost criteria analys studi primari research aim develop valid critic apprais diagnost criteria dermatolog condit identifi pubm search conduct juli research skin diseas group base similar pathogenesi total studi cover skin diseas includ data extract two largest diseas categori autoimmun diseas rare disord genet syndrom total studi analys includ type valid provid diagnost accuraci data map diagnost criteria cover vast rang dermatolog condit mani common skin diseas repres plan updat map make avail health profession research

D001327;D012871

T047

symmetr molecular dynam deriv formul molecular dynam generat symmetr configur implement planar space group atlas lennard jone crystal planar group creat symmetr molecular dynam

D056004

T044;T066

print control micropor scaffold support embryon develop vitro littl known complex molecular cellular event occur implant repres critic step pregnanc convent cultur could support postimplant embryo normal develop condit shed light black box print technolog wide use recapitul structur function nativ tissu vitro print anisotrop micropor scaffold cultur embryo manipul advanc angl print layer affect embryo develop scaffold promot embryo develop moder embryo scaffold attach posit cell foxa posit cell observ appear posterior region embryo migrat anterior region embryo day find demonstr print stand support embryon develop vitro critic role architectur embryo implant addit manufactur versatil tool

D047108;D066330;D054457

T073;T038;T122;T042;T039

recent advanc diagnosi therapi larg vessel vascul larg vessel vascul lvv includ takayasu arter tak giant cell arter gca caus granulomat vascular inflamm main larg vessel common primari vascul adult vascular inflamm may evok mani clinic featur includ vision impair stroke limb ischemia aortic aneurysm best way diagnos lvv combin medic histori physic examin various laboratori test imag modal progress imag modal facilit earli diagnosi followup diseas activ convent angiographi longer gold standard diagnosi tak similar tempor arteri biopsi longer tool diagnos cranial gca select case color doppler ultrasound may use purpos despit similar tak gca differ mani aspect differ diseas also differ clinic subtyp presenc aortiti alway implic diagnosi tak gca infecti aortiti well noninfecti aortiti associ autoimmun rheumat diseas exclud treatment lvv includ glucocorticoid gcs convent immunosuppress agent biolog drug tumor necrosi factor inhibitor ineffect gca effect tak hand tocilizumab may use treat diseas promis target therapi evalu ongo clinic trial includ exampl antiil ustekinumab antiil secukinumab antiil anakinra antiil guselkumab anticytotox tlymphocyt antigen abatacept janus kinas inhibitor tofacitinib upadacitinib antigranulocyt macrophag colonystimul factor mavrilimumab endothelin receptor bosentan therapi

D001025;D013700;D013625

T047

label free imag lipid droplet prostat cell use stimul raman scatter microscopi multivari analysi hyperspectr stimul raman scatter srs microscopi power imag modal analysi biolog system report applic k mean cluster analysi kmca multi wavelength srs imag high wavenumb region raman spectrum robust reliabl method segment cellular organell base intrins srs spectrum kmca appli studi endogen lipid biochemistri prostat cancer prostat healthi cell model correspond srs spectrum lipid droplet ld cluster enabl direct comparison composit applic kmca visual ld content prostat cell model follow inhibit de novo lipid synthesi dnl use acetyl coa carboxylas inhibitor tetradecyloxi furoic acid tofa demonstr method identifi relianc prostat cancer cell model upon dnl metabol requir signific reduct cellular ld content treatment tofa observ normal prostat cell model srs imag combin kmca robust method investig drug cell interact label free manner

D066292;D011471

T191;T026

kiss basaloid follicular hamartoma eyelid basaloid follicular hamartoma bfhs rare benign cutan adnex tumor character branch cord anastomos strand basaloid cell loos fibrous stroma bfhs exhibit variabl clinic present although common observ skin color papul diagnos base histopatholog featur common system diseas associ bfh includ alopecia myasthenia gravi palmoplantar pit bfh eyelid extrem rare five case report literatur date congenit kiss lesion previous report nevi present novel case congenit kiss bfh right upper right lower eyelid histopatholog examin reveal intraderm nodul basaloid cell form reticul strand pseudohorn cyst mucin stroma palisad cd bcl express stromal fibroblast peripheri respect

D006222;D012871;D012878

T191;T047

genom enabl discoveri candid virul loci striga hermonthica devast parasit african cereal crop parasit evolv protein virul factor vfs facilit plant colonis howev vfs mediat parasit plant host interact poor understood striga hermonthica oblig root parasit plant cereal host sub saharan africa caus devast yield loss understand molecular natur allel variat vfs hermonthica essenti breed resist delay evolut parasit virul assembl hermonthica genom identifi secret protein use silico predict pool sequenc parasit grow suscept strong resist rice host allow us scan loci select impos resist host elev frequenc allel contribut success colonis thirti eight putat secret vfs differ allel frequenc function includ host cell wall modif proteas proteas inhibitor kinas activ candid loci signific higher tajima genom background consist balanc select result reveal divers strategi use hermonthica overcom differ layer host resist understand mainten variat virul loci balanc select critic manag evolut virul part sustain control strategi

D010271;D034362

T002;T204

paroxysm nocturn hemoglobinuria advanc understand pathophysiolog diagnosi treatment recent year old paroxysm nocturn hemoglobinuria pnh achiev new advanc term understand pathophysiolog modern approach diagnost optim therapi dynam develop new therapeut agent review emphas greater previous recogn import reduc suscept pnh stem cell apoptosi select defect clone chang cytokin chemokin profil patient pnh interpret context autoimmun apoptosi classif pnh present characterist function select glycosylphosphatidylinositol anchor protein well patholog associ hemolysi thrombosi bone marrow failur describ current diagnost process various form pnh present detail well import choic treatment prognosi diseas cours determin modern treatment strategi complement c inhibitor vs hematopoiet stem cell allotransplant safeti efficaci treatment eculizumab ravulizumab polici initi monitor treatment criteria respons treatment final outcom treatment describ among new therapeut agent crovalimab c inhibitor less advanc stage research discuss tesidolumab pozelimab zilucoplan nomacopan cemdisiran first approv proxim complement pathway inhibitor primarili prevent extravascular hemolysi pegcetacoplan danikopan iptacopan present potenti benefit highlight

D006457

T047

eosinophil pustular follicul develop site covid vaccin present rare case eosinophil pustular follicul due mrna base vaccin covid histolog biopsi specimen interest

D000086382;D005499

T047;T067

safeti toler medi ox agonist mab combin durvalumab tremelimumab adult patient advanc solid tumor combin therapi target immunolog checkpoint shown promis treat multipl tumor type report safeti toler medi human iggk ox mab combin durvalumab anti pd l tremelimumab anti ctla adult patient previous treat advanc solid tumor

D000971;D009369

T191;T061

label free character quantif mucos inflamm common murin coliti model multiphoton imag clinic challeng inflammatori bowel diseas requir microscop vivo evalu inflamm label free imag hold great potenti recent group demonstr advantag use vivo multiphoton endomicroscopi longitudin anim studi articl extend previous work depth analysi label free tissu featur common coliti model quantifi multiphoton coliti score mcs

D003092;D015212

T047

immun boost b omicron depend previous sar cov exposur omicron pango lineag b variant sever acut respiratori syndrom coronavirus sar cov carri multipl spike mutat high transmiss partial neutral antibodi nab escap vaccin individu show protect sever diseas often attribut prime cellular immun investig b cell immun b tripl biontech bntb messeng rna vaccin health care worker hcws differ sar cov infect histori b cell immun previous variant concern enhanc tripl vaccin individu magnitud b cell respons b spike protein reduc immun imprint infect earlier b alpha variant result less durabl bind antibodi b previous infect nave hcws becam infect b wave show enhanc immun earlier variant reduc nab potenc cell respons b previous wuhan hu infect abrog cell recognit enhanc cross reactiv neutral immun infect b

D001402;D000090982;D000086382;D007117;D000086402;D013601

T047;T116;T061;T121;T005;T109;T200;T114;T129;T025;T067

make success patient navig implement cancer prevent screen program use evalu sustain framework integr patient navig cancer prevent earli detect effort effect increas cancer screen rate medic underserv public focus cancer screen intervent primari care set use patient navig primari strategi implement adapt sustain univers colorado cancer center establish statewid colorect cancer screen program reduc dispar improv colorect cancer crc screen medic underserv partnership safeti net system program known colorado cancer screen program ccsp provid navig prevent screen patient

D015179;D062526

T191;T058;T097

compar clinic nonclin cancer patient navig nation studi unit state nationwid survey conduct examin differ clinic nonclin oncolog navig servic provis engag cancer care continuum person characterist program characterist

D009369;D062526

T191;T058;T097

establish health profess oncolog patient navig learn nation associ communiti health worker person identifi communiti health worker chws may hold titl andor certif includ titl patient navig pn pn role first emerg dr harold freeman initi harlem hospit strategi reduc dispar access health care wherea chw role extend beyond health system predomin found communiti base organ nonprofit although chws origin unit state predat pns growth chws profession ident nation represent trail pns despit evid chws effect sinc barrier progress includ pattern short term inequit fund chw posit lack employ support particip associ busi broad divers chw role work set nation associ communiti health worker nachw launch built earlier organ effort multisector multicultur chws alli chw section american public health associ effort creat american associ communiti health worker trend health care financ increas call racial equiti coronavirus diseas covid pandem amplifi uniqu abil trust chws appli underresourc margin multiethn popul address social determin health health system access cost qualiti result nachw forefront effort improv feder fund covid respons sustain fund chws organ beyond pandem drive equiti rebuild public health infrastructur transform payment model health system lesson learn process implic oncolog patient navig field includ persist need reinforc valu self determin profess matter polici import activ cultiv uniti among divers cultur practic group within profess essenti role activ volunt leadership earli staf substanti financi support extend startup period ongo need leadership develop within workforc limit exposur profession associ cultur vital import ongo effort collabor build capac among state level chw network valu opportunist nation collabor rapid evolv polici environ

D000086382;D062526

T058;T047;T097;T067

collect pursuit equiti cancer care nation navig roundtabl evid continu build support implement patient navig reduc barrier increas access care howev health dispar remain cancer outcom goal nation navig roundtabl nnrt serv conven help support field navig address equiti

D000086382;D009369;D062526

T047;T058;T191;T097;T067

solidifi role respons process navig across continuum cancer care profession oncolog navig task forc sinc found profess oncolog navig grown evolv although core concept serv unifi thread throughout profess formal agreement standard definit scope role various type navig creat challeng sustain includ reimburs navig servic emerg biden cancer initi patient navig work group profession oncolog navig task forc creat serv voic profession oncolog organ ultim goal solidifi definit scope role navig across care continuum task group member commit cross disciplinari partnership includ nurs social work nonclin licens navig task forc work defin refin dissemin profession standard input navig communiti work done nation navig roundtabl vital evolv understand profess articl outlin import partnership highlight relev find articl supplement cancer standard work lay summari within profess oncolog navig definit scope role navig solidifi standard profess critic allow continu growth evolut well polici direct articl introduc work profession oncolog navig task forc creat oncolog navig standard profession practic input profession leader communiti stakehold articl also link work nation navig roundtabl critic need coordin amplifi effort across group

D009369;D062526

T191;T058;T097

chang agent oncolog workforc let clear communiti health worker patient navig despit effort profession organ govern agenc solidifi profession ident communiti health worker patient navig oncolog workforc scientif literatur perpetu wide variat nomenclatur use defin natur chang agent proven efficaci improv access qualiti cancer care histor margin popul dissemin sustain scale life save role cancer care oncolog field must come togeth adopt clear consist job titl occup ident

D003150;D062526

T058;T097;T102

explor class cancer patient navig determin navig role retent current nationwid studi author use latent class analysi lca identifi class cancer patient navig cpns examin whether class membership indic relat navig role retent

D009369;D062526

T191;T058;T097

barrier opportun measur oncolog patient navig impact result nation navig roundtabl survey patient navig improv cancer care deliveri risk poor outcom lack sustain fund threaten full integr navig servic health care deliveri system standard navig metric document impact identifi best practic necessari support sustain

D009369;D062526

T191;T058;T097

develop workflow process map protocol inform implement region patient navig program breast oncolog implement citi wide patient navig process support patient across continuum cancer care imped lack standard tool integr workflow reduc gap care author present action workflow process map protocol navig process plan improv base method develop translat research practic studi

D001943;D062526

T191;T058;T097

patient navig address socioleg barrier patient cancer compar effect studi socioleg barrier cancer care defin health relat social need like afford healthi hous stabl util servic food secur may remedi public polici law regul program legal support studi cancer care

D001943;D008175;D062526

T191;T058;T097

evalu sustain patient navig program oncolog length exist fund payment model particip studi author examin whether specif programmat factor associ sustain patient navig program

D062526

T058;T097

american cancer societi patient navig past futur perspect past year american cancer societi ac play key role shape field patient navig mean address cancer dispar collabor organ like nation navig roundtabl ac cancer action network ac uniqu posit help develop sustain navig model direct address dispar access qualiti cancer care health system continu adapt chang respons various factor includ age popul rapid advanc screen treatment import evalu exist navig deliveri model promot sustain maxim reach impact provid greatest return invest roi report term roi use describ potenti financi gain result navig servic roi net gainstot program cost calcul net gain requir assign monetari valu key outcom subtract amount total program cost roi measur often use health care execut show save financi benefit program servic measur financi impact exist may greater lesser valu program leadership includ cost effect financi inform outcom avail cost benefit analysi current futur commit ac advanc field patient navig outlin organiz prioriti key build block health equiti strategi work partner like nation navig roundtabl ac help guid effort evalu approach goal identifi effect potenti sustain model deliveri also increas equit access care

D009369;D062526

T191;T058;T097