diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo.srt new file mode 100644 index 0000000000000000000000000000000000000000..ecf8263b6d2b0d2a8bc3504a6c9becbc0998a13a --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo.srt @@ -0,0 +1,1652 @@ +1 +00:00:01,690 --> 00:00:06,950 +اللهمّ من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى هذا الفصل في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في الـ outlines حكينا إنه هذا المساق بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتم عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبا بتنقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +الثلاثة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش إني أحفظ إيش تعريف الأنيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش الـ pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط هذه النتائج مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مصاحبة لهذا الـ result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات عشان أتأكد من الـ results معينة هذا + +20 +00:01:32,370 --> 00:01:36,270 +الكلام بإذن الله كله راح نناقشه مع بعض شوية شوية + +21 +00:01:36,270 --> 00:01:37,690 +أول حاجة هنشرحها بعد + +22 +00:01:53,930 --> 00:01:58,290 +الخلل هذا طبعا بيكون خلل في الـ Alpha أو في الـ + +23 +00:01:58,290 --> 00:02:04,050 +Beta-H-chain خلايا عادة بتكون hypochromic + +24 +00:02:04,050 --> 00:02:08,310 +microcytic cells طبعا بتتميز بوجود كمية من الـ + +25 +00:02:08,310 --> 00:02:13,450 +target cells فيها genetic mutation specified by + +26 +00:02:13,450 --> 00:02:16,530 +يعني الـ mutation فيها قد تكون في الـ Beta-H-chain + +27 +00:02:16,790 --> 00:02:19,350 +وقد تكون في الـ Alpha Chain إذا كان نقص في الـ + +28 +00:02:19,350 --> 00:02:22,410 +Beta Chain نقص في تصنيع الـ Beta Chain بسميها Beta + +29 +00:02:22,410 --> 00:02:25,410 +-thalassemia وهذه شائعة في اليونان وفي إيطاليا إذا + +30 +00:02:25,410 --> 00:02:27,890 +كان نقص في الـ Alpha Chain بسميها Alpha + +31 +00:02:27,890 --> 00:02:31,510 +-thalassemia طبعا احنا عارفين الـ Hemoglobin + +32 +00:02:31,510 --> 00:02:35,610 +Molecule Hemoglobin Molecule أربعة Globin Chain + +33 +00:02:35,610 --> 00:02:40,110 +وأربعة هيم جروب Hemoglobin chain مثلا هي + +34 +00:02:40,110 --> 00:02:44,430 +Hemoglobin molecule العادي بيكون فيه هي Hem Hem + +35 +00:02:44,430 --> 00:02:48,750 +Hem أربع Hem وفي عنده الـ globin الـ globin بتكون من + +36 +00:02:48,750 --> 00:02:52,130 +two alpha و two beta chain في الـ adult الـ normal + +37 +00:02:52,130 --> 00:02:58,650 +هلاقي 97% من الـ hemoglobin Hemoglobin A بنلاقي نسبة + +38 +00:02:58,650 --> 00:03:03,030 +بسيطة من Hemoglobin A2 بتشكل 2% A2 بتكون من 2 + +39 +00:03:03,030 --> 00:03:07,590 +Alpha مع 2 Delta Hemoglobin F بتشكل برضه نسبة + +40 +00:03:07,590 --> 00:03:12,130 +بسيطة تقريبا 1% أو أقل اثنتين Gamma واثنتين Alpha + +41 +00:03:12,130 --> 00:03:14,970 +يعني الثلاثة بيشتركوا في وجود Alpha Chain زي ما + +42 +00:03:14,970 --> 00:03:15,610 +أنتم شايفين + +43 +00:04:56,960 --> 00:05:01,040 +الـ Thalassemia زي ما أنتم عارفين قد تكون lethal وقد تكون + +44 +00:05:01,040 --> 00:05:06,280 +يعني مرضى بيعتمدوا على transfusion بشكل مستمر يعني + +45 +00:05:06,280 --> 00:05:11,580 +عايشين على blood transfusion أو بدون أي symptoms + +46 +00:05:11,580 --> 00:05:14,640 +يعني بيكونوا عايشين حياتهم طبيعية وده بيعتمد على + +47 +00:05:14,640 --> 00:05:18,580 +عدد الجينات اللي اتأثرت وبالتالي عدد الـ chains + +48 +00:05:18,580 --> 00:05:22,580 +اللي اتأثرت في الـ hemoglobin طبعا الـ majorالـ + +49 +00:05:22,580 --> 00:05:26,420 +major زي ما أنتم عارفين بيصير خلل كله في الـ + +50 +00:05:26,420 --> 00:05:29,460 +chain يعني مافيش Alpha ولا فيه Beta يا إما مافيش + +51 +00:05:29,460 --> 00:05:32,580 +Beta خالص فبالتالي الـ hemoglobin الطبيعي مش راح + +52 +00:05:32,580 --> 00:05:36,240 +يتصنع الـ alpha chain للـ hemoglobinالـ Minor + +53 +00:05:36,240 --> 00:05:41,260 +بيبقى فيه خلل في مثلا واحدة Alpha خلل في واحدة + +54 +00:05:41,260 --> 00:05:47,560 +Beta فبالتالي بيصير نفس بسيط في نقص معين أو بسيط + +55 +00:05:47,560 --> 00:05:51,640 +في نوع الـ Hemoglobin حسب الخلل اللي صار بيصير خلل + +56 +00:05:51,640 --> 00:05:56,940 +في تصنيع الـ Beta Chain وبالتالي بيصير عندنا هنيجي + +57 +00:05:56,940 --> 00:05:59,840 +للـ Beta-thalassemia major، homozygous هنا بيبقى + +58 +00:05:59,840 --> 00:06:03,700 +في الـ Beta-charritin تان الـ gene تبعهم ضارب، + +59 +00:06:03,700 --> 00:06:07,260 +خربان يعني مافيش عندي Beta-chain خالص هدول المرضى + +60 +00:06:07,260 --> 00:06:11,280 +بيعتمدوا بشكل أساسي على blood transfusion بتلاقي + +61 +00:06:11,280 --> 00:06:14,800 +الـ RBCs بتصير rigid ليش؟ لأنه فيها hen's body هذه + +62 +00:06:14,800 --> 00:06:17,540 +الـ hen's body من وين أجت من تراكم الـ Alpha-chain + +63 +00:06:17,540 --> 00:06:22,590 +لزيادة وطبعا هذا بيؤدي لتكسير الخلايا قد يؤدي لتكسير + +64 +00:06:22,590 --> 00:06:26,190 +الخلايا هاي هنا عندنا صورة بتوضّح تراكم الـ hens + +65 +00:06:26,190 --> 00:06:31,670 +bodies في الخلايا طبعا أي خلية فيها hens body حتى + +66 +00:06:31,670 --> 00:06:38,410 +تاخدها الماكروفاج وتعملها طيب + +67 +00:06:38,410 --> 00:06:42,430 +الـ lab finding عند هدول الناس severe anemia بلاقي + +68 +00:06:42,430 --> 00:06:46,570 +target cells بشكل كثير كبير بلاقي الـ Nucleated RBCs + +69 +00:06:46,570 --> 00:06:49,730 +لأنه تكسير فبالتالي البون مارو بده يعود فبلاقي الـ + +70 +00:06:49,730 --> 00:06:52,950 +Nucleated RBCs برضه الـ reticulocyte بتكون عالية + +71 +00:06:52,950 --> 00:06:56,910 +هيهد الـ Nucleated RBCs إذا فاكرينها بلاقي الـ + +72 +00:06:56,910 --> 00:06:59,490 +Inclusion Bodies زي الـ Basophilic Stippling اللي + +73 +00:06:59,490 --> 00:07:02,850 +هي بتكون نقاط من الريبوزومة الـ RNA في الخلية + +74 +00:07:02,850 --> 00:07:07,290 +مابلاقيش عندهم خالص Hemoglobin A وإنما تم استبداله + +75 +00:07:07,290 --> 00:07:10,590 +بالـ Gamma Chain Beta Chain ضربت تصنع بدلها + +76 +00:07:10,590 --> 00:07:15,360 +Gamma Chain وصار عندهم Hemoglobin F بكمية كبيرة + +77 +00:07:15,360 --> 00:07:19,880 +طبعا + +78 +00:07:19,880 --> 00:07:23,980 +علاجهم الـ Transfusion اسمه Splenectomy، Iron + +79 +00:07:23,980 --> 00:07:28,980 +-chelating agent هاي Blood Film فيه Nucleated RBC + +80 +00:07:28,980 --> 00:07:34,340 +في Heinz Bodies فيه يعني هنا مقشر حاجة لطيفة مقشر + +81 +00:07:34,340 --> 00:07:39,600 +هنا على RBC عادية وكويسة يعني هذه عادة بتكون من الـ + +82 +00:07:39,600 --> 00:07:44,370 +Blood Transfusion تمام hypercellular bone marrow + +83 +00:07:44,370 --> 00:07:48,630 +نيجي + +84 +00:07:48,630 --> 00:07:54,390 +للـ Beta-thalassemia minor طبعا هنا بيكون الـ beta + +85 +00:07:54,390 --> 00:07:58,370 +chain واحدة فيهم فيها مشكلة أو واحدة فيها طبيعية + +86 +00:07:58,370 --> 00:08:02,670 +فبالتالي بيصير نقص في تصنيع الـ beta chain لكن مش + +87 +00:08:02,670 --> 00:08:06,370 +انعدام ممكن ألاقي الـ blood picture زي الشخص + +88 +00:08:06,370 --> 00:08:10,370 +الطبيعي وحتى يعني لو ما دور حاله أو ما شكش إنه عنده + +89 +00:08:10,370 --> 00:08:13,490 +beta-thalassemia وراح دور حاله ممكن مايعرفش، بتكون + +90 +00:08:13,490 --> 00:08:17,590 +أنيميا mild ممكن ألاقي بعض الـ target cell، + +91 +00:08:17,590 --> 00:08:20,710 +مابلاقيش الـ nucleated RBCs ممكن أشوف basophilic + +92 +00:08:20,710 --> 00:08:24,730 +stippling، Heinz bodies مافيش، serum iron بيكون + +93 +00:08:24,730 --> 00:08:30,830 +طبيعي، هلاقي هنا عندهم زيادة في Hemoglobin A2 نيجي + +94 +00:08:30,830 --> 00:08:35,240 +للـ alpha-thalassemia الألفا ثلاثيميا زي ما أنتم + +95 +00:08:35,240 --> 00:08:40,220 +عارفين في عندي أربع جينات طبعا اللي مسئولة عن الـ + +96 +00:08:40,220 --> 00:08:45,020 +Alpha Chain أحيانا بيبقى الأربع جينات ضاربين + +97 +00:08:45,020 --> 00:08:49,220 +فبالتالي مافيش عندنا Alpha Chain خالص بتتصنع طبعا + +98 +00:08:49,220 --> 00:08:54,360 +هذا يعني بنشأ طفل يعني بيموت Hydrops Fetalis + +99 +00:08:54,360 --> 00:08:59,660 +مابيقدرش يكمل بسميها طبعا Alpha Thalassemia Major + +100 +00:08:59,660 --> 00:09:04,960 +Homozygous مافيش عندنا Alpha Chain النوع الثاني + +101 +00:09:04,960 --> 00:09:09,260 +اللي هو الـ Alpha-thalassemia intermediate الـ + +102 +00:09:09,260 --> 00:09:13,180 +Alpha-thalassemia intermediate عادةً بيكونوا ثلاثة + +103 +00:09:13,180 --> 00:09:16,380 +من الجينات اتأثروا أو صارلهم deletion هنا بيصير + +104 +00:09:16,380 --> 00:09:20,480 +moderate decrease in Alpha-chain synthesis طبعا + +105 +00:09:20,480 --> 00:09:24,420 +بيصير زيادة في الـ Beta-chain بنشأ عنها أنص stable + +106 +00:09:24,420 --> 00:09:26,920 +hemoglobin H اللي هو بتكون من أربعة Beta-chain + +107 +00:09:26,920 --> 00:09:33,150 +وبيعمل ترسيب في الخلية على شكل hen's body طبعا هذا + +108 +00:09:33,150 --> 00:09:37,210 +هيصير لـ Thalassemia + +109 +00:09:37,210 --> 00:09:41,370 +minor طبعا بيكون هنا deletion لواحد أو اثنين من + +110 +00:09:41,370 --> 00:09:45,770 +الـ alpha chain احنا قلنا الـ major أربعة الـ + +111 +00:09:45,770 --> 00:09:49,430 +intermediate ثلاثة هنا اثنين أو واحد هنا بيصير + +112 +00:09:49,430 --> 00:09:52,870 +slight decrease in alpha chain production mild or + +113 +00:09:52,870 --> 00:09:56,010 +no anemia بنلاقي فيها بعض الـ target cells + +114 +00:09:56,290 --> 00:10:00,430 +Essentially Normal Electrophoresis ممكن ما نقدرش + +115 +00:10:00,430 --> 00:10:03,490 +نعمل لها diagnosis وتعدي يعني تكون الـ + +116 +00:10:03,490 --> 00:10:05,970 +Electrophoresis هي الـ Normal هذا الـ Normal + +117 +00:10:05,970 --> 00:10:08,750 +Electrophoresis الـ Beta-thalassemia major لأن + +118 +00:10:08,750 --> 00:10:12,470 +الهيموجلوبين الـ F هو اللي بيرتفع Beta-thalassemia minor + +119 +00:10:12,470 --> 00:10:15,830 +بتلاقي ارتفاع شوية في الهيموجلوبين الـ A2 الـ Alpha + +120 +00:10:15,830 --> 00:10:19,670 +-thalassemia هتلاقيها تقريبا الـ Alpha-thalassemia + +121 +00:10:19,670 --> 00:10:23,710 +major هذه هتلاقي إنه في complete absence للـ + +122 +00:10:25,340 --> 00:10:28,380 +الهيموجلوبين A فبالتالي هيتكون انتي بارد بارد + +123 +00:10:28,380 --> 00:10:33,580 +الهيموجلوبين البارد هيموجلوبين طبعا هذه قلنا عن + +124 +00:10:33,580 --> 00:10:37,100 +Hydrops Fetalis بس أنا هنا بدي أقول لكم كمان في الـ + +125 +00:10:37,100 --> 00:10:39,640 +alpha-thalassemia intermediate هنلاقي الـ alpha + +126 +00:10:39,640 --> 00:10:42,700 +-thalassemia minor هنلاقي الـ electrophoresis لها + +127 +00:10:42,700 --> 00:10:44,720 +زي وزي الـ normal electrophoresis + +128 +00:10:47,960 --> 00:10:51,840 +بالكلام اللي حكيناه بس أنا بدي أورجيكم نسب الـ + +129 +00:10:51,840 --> 00:10:54,500 +Hemoglobin في كل حالة يعني عند الـ Beta + +130 +00:10:54,500 --> 00:10:57,940 +-thalassemia في عند الـ homozygous هنلاقي + +131 +00:10:57,940 --> 00:11:02,560 +Hemoglobin F من 40 إلى 90% في الـ Beta-thalassemia + +132 +00:11:02,560 --> 00:11:07,760 +minor هنلاقي Hemoglobin A2 هو الارتفاع بس برضه مش + +133 +00:11:07,760 --> 00:11:14,240 +هيرتفع كتير من 3.5 إلى 7% Hemoglobin F هتلاقيه + +134 +00:11:14,240 --> 00:11:16,320 +normal في 50% من الحالات + +135 +00:11:19,280 --> 00:11:22,520 +بالنسبة للـ Alpha-thalassemia الـ homozygous الـ + +136 +00:11:22,520 --> 00:11:26,860 +major هنلاقي hemoglobin parts بشكل 80% في الـ cord + +137 +00:11:26,860 --> 00:11:32,530 +blood طبعا بعد هيك تيجي عند الـ Intermediate هتلاقي + +138 +00:11:32,530 --> 00:11:37,190 +Hemoglobin H نسبته من 4 إلى 30% unstable or non + +139 +00:11:37,190 --> 00:11:39,730 +-functional بسيروتكسير الـ Alpha-thalassemia + +140 +00:11:39,730 --> 00:11:43,730 +heterozygous هتلاقي فيها Hemoglobin parts من 1 إلى + +141 +00:11:43,730 --> 00:11:48,610 +10% في الـ cord blood مش في الأدل طبعا Hemoglobin H + +142 +00:11:48,610 --> 00:11:52,770 +نادر لما نشوفه في الـ cord blood والـ Hemoglobin A + +143 +00:11:52,770 --> 00:11:55,710 +تقريباً هيكون فيه slight decrease والبقية النامية + +144 +00:11:55,710 --> 00:11:58,490 +هيكون الـ profile بتاعها زي وزي الـ normal + +145 +00:11:58,490 --> 00:12:03,750 +Hemoglobin Electro في كل شيء + +146 +00:12:03,750 --> 00:12:08,250 +هنا + +147 +00:12:08,250 --> 00:12:11,530 +يعني عمللي differential diagnosis بين الأنواع + +148 +00:12:11,530 --> 00:12:16,710 +المختلفة لـ microcytic anemia اللي هم الـ beta + +149 +00:12:16,710 --> 00:12:19,050 +-thalassemia و الـ alpha-thalassemia ال + +150 +00:12:19,050 --> 00:12:24,150 +sideroplastic و الـ iron deficiency هنا طبعا مش ذاكر + +151 +00:12:24,150 --> 00:12:27,390 +الـ CPC لأن الـ CPC أنا بلزمني بس عشان أفرق بين + +152 +00:12:27,390 --> 00:12:31,310 +الثلاثيميا والـ Iron deficiency تمام الـ CPC + +153 +00:12:31,310 --> 00:12:34,970 +تقريبا بتلاقي يعني الـ blood indices والأشياء هذه + +154 +00:12:34,970 --> 00:12:40,310 +متشابهة فيهم كلهم إلا بعض الفرقات هناخدها بالشريحة + +155 +00:12:40,310 --> 00:12:46,450 +التالية اللي بعدها طيب نيجي أول حاجة في الـ Iron + +156 +00:12:46,450 --> 00:12:52,670 +deficiency anemia serum iron level هينقص بديهي + +157 +00:12:52,670 --> 00:12:56,590 +تمام؟ والـ Total Iron Binding Capacity هتزيد + +158 +00:12:56,590 --> 00:13:00,550 +والفيريتين هينقص عكسها تماما الـ Sideroplastic + +159 +00:13:00,550 --> 00:13:04,630 +Anemia زيادة الحديد نقص الـ Total Iron Binding + +160 +00:13:04,630 --> 00:13:10,850 +Capacity زيادة الفيريتين تمام هيك؟ الثلاثيميا + +161 +00:13:10,850 --> 00:13:14,270 +مالهاش دعوة في الحديد نيجي للـ Hemoglobin + +162 +00:13:14,270 --> 00:13:16,790 +Electrophoresis في الـ Iron Deficiency Anemia + +163 +00:13:16,790 --> 00:13:20,830 +مافيش خلل في الـ Hemoglobin يعني هيكون Normal في + +164 +00:13:20,830 --> 00:13:24,090 +الـ Beta-thalassemia حيصير زيادة في Hemoglobin A2 + +165 +00:13:24,090 --> 00:13:27,310 +Alpha-thalassemia Hemoglobin A2 هيكون normal في + +166 +00:13:27,310 --> 00:13:29,590 +السيدروبلاستيك أنيميا هيكون normal يعني المشكلة وين + +167 +00:13:29,590 --> 00:13:33,590 +في الـ Beta-thalassemia هيكون في زيادة هذه أشياء + +168 +00:13:33,590 --> 00:13:37,450 +يعني مش شرط يعني مش بقياس كتير يعني زي مثلًا + +169 +00:13:37,450 --> 00:13:40,310 +Basophilic Stippling أكيد بتوجدش في الـIron في شنصي + +170 +00:13:40,310 --> 00:13:43,290 +أنيميا لكن ممكن توجد في الأنواع التانية فبنهاية + +171 +00:13:43,290 --> 00:13:48,070 +ممكن تجيزي لأكتر حاجتين بغلبونا في التشخيص الصحيح + +172 +00:13:48,560 --> 00:13:52,060 +وهناخد عليهم cases كتير ونطبق بإذن الله اللي هم + +173 +00:13:52,060 --> 00:13:54,780 +الـ Iron deficient anemia والثلاثيميا خاصة طبعا + +174 +00:13:54,780 --> 00:13:58,420 +الـ Thalassemia trait في عندي بعض الأشياء بدي + +175 +00:13:58,420 --> 00:14:02,840 +ألاحظ يعني أفرق بينهم خليني يعني أشوف المنذر index + +176 +00:14:02,840 --> 00:14:08,620 +هذا عادة MCV على RBCs أقل من 13 في الثلاثيميا يعني + +177 +00:14:08,620 --> 00:14:14,120 +احنا يعني ممكن نلاقي حالة مش ثابتة معها الكريتيريا + +178 +00:14:14,120 --> 00:14:18,590 +هذه كلها فبنضطر نضيف فحصات تانية أو حتى يعني نعمل + +179 +00:14:18,590 --> 00:14:22,630 +Hemoglobin A2 and so on يعني الـ CBC لوحده يعني + +180 +00:14:22,630 --> 00:14:25,630 +مابيعطناش diagnosis نهائي للثلاثيميا والـ Iron + +181 +00:14:25,630 --> 00:14:28,350 +Deficiency يعني مافي بعض الحالات بتكون واضحة وفي + +182 +00:14:28,350 --> 00:14:32,550 +حالات بتكون بين بين وممكن نلجأ لهيموجلوبين A2 أو + +183 +00:14:32,550 --> 00:14:35,310 +Hemoglobin A2 أو فحص الـ electrophoresis عشان + +184 +00:14:35,310 --> 00:14:40,950 +نميزهم عن بعض طيب نيجي للـ RBCs الـ RBCs هي بنادسة + +185 +00:14:40,950 --> 00:14:44,700 +الثلاثيميا بتكون عالية ليش؟ بأن الـ bone marrow + +186 +00:14:44,700 --> 00:14:48,100 +بيكون hypercellular يعني بيبقى فيه تكسير وبالتالي + +187 +00:14:48,100 --> 00:14:52,460 +فيه تصنيع أكتر فبالتالي هتلاقي RBCs كتير على خلاف + +188 +00:14:52,460 --> 00:14:54,960 +الـ Iron deficiency أنيمية عادة الـ RBCs فيها + +189 +00:14:54,960 --> 00:14:58,840 +قليلة الـ Thalassemia بتلاقي الـ RBCs فيها فوق + +190 +00:14:58,840 --> 00:15:01,920 +الخمسة بينما الـ Iron deficiency أقل من خمسة أو + +191 +00:15:01,920 --> 00:15:08,230 +أقل من أربع كمان يعني الـ MCV عادة أقل من 70 في الـ + +192 +00:15:08,230 --> 00:15:10,470 +Thalassemia trait وأكتر من 70 في الـ Iron + +193 +00:15:10,470 --> 00:15:12,310 +deficiency anemia يعني قد ما بنقص في الـ Iron + +194 +00:15:12,310 --> 00:15:15,250 +deficiency anemia وإن كان ممكن ينقص عن 70 يعني في + +195 +00:15:15,250 --> 00:15:20,250 +حالتها نشوفها في Iron deficiency أقل من 70 Red + +196 +00:15:20,250 --> 00:15:23,270 +distribution with RDW في الـ Iron deficiency + +197 +00:15:23,270 --> 00:15:27,930 +anemia بتلاقي عالي هو هد عبارة عن إيش الـ RDW الـ + +198 +00:15:27,930 --> 00:15:33,440 +RDW هو مقدار الـ variation بين أحجام الخلايا مقدار + +199 +00:15:33,440 --> 00:15:37,420 +الـ variation بين أحجام الخلايا يعني بيدل على إنه + +200 +00:15:37,420 --> 00:15:40,600 +في عندك كام population من الخلايا الـ Iron + +201 +00:15:40,600 --> 00:15:44,500 +deficiency عادة مش قلتلكم إنه بتمر بمراحل يعني في + +202 +00:15:44,500 --> 00:15:47,480 +stage 1 و stage 2 و stage 3 فبالتالي مش هتلاقي كل + +203 +00:15:47,480 --> 00:15:52,480 +الخلايا نفس الـ stage في خلايا نقص عليها الحديد وفي + +204 +00:15:52,480 --> 00:15:56,220 +خلايا لسه كويسة وعمر الخلايا 120 يوم فبالتالي + +205 +00:15:56,220 --> 00:15:58,540 +هنلاقي فيه تباين في أحجام الخلايا في الـ Iron + +206 +00:15:58,540 --> 00:16:02,340 +deficiency بيرتفع الـ RDW بينما في الثلاثيميا + +207 +00:16:02,340 --> 00:16:07,500 +بتلاقيها كلها صغيرة زي بعض هتلاقي الـ RDW أقل من + +208 +00:16:07,500 --> 00:16:13,620 +17% تمام؟ وهذا الكلام يعني هنحكي فيه أكتر من هيك و + +209 +00:16:13,620 --> 00:16:18,080 +هنحاول نجيب علاقات يعني أشياء معينة من خلال الـ + +210 +00:16:18,080 --> 00:16:22,760 +CPC نربط بينها ونحاول نعرف الحالة إذا كانت Iron + +211 +00:16:22,760 --> 00:16:25,120 +deficiency anemia أو لا ثلاثيميا عند التطبيق يعني + +212 +00:16:25,120 --> 00:16:29,500 +بيكون أهم لأن أحيانًا بيصير تداخلمابتلاقيش يعني + +213 +00:16:29,500 --> 00:16:32,080 +مابتلاقيش خط فاصل هي ثلاثيميا ولا iron deficiency + +214 +00:16:32,080 --> 00:16:35,700 +انميا فبنصير نرجح يعني بتلاقي كل مثلا الـ criteria + +215 +00:16:35,700 --> 00:16:40,500 +بتقول انها ثلاثيميا لكن بتلاقي الـ RDW عالي طب إيش + +216 +00:16:40,500 --> 00:16:44,400 +هي؟ طب هي ممكن تكون ثلاثيميا ودخلت على خط الـ iron + +217 +00:16:44,400 --> 00:16:47,380 +deficiency صارت ثلاثيميا مركبة على iron deficiency + +218 +00:16:47,380 --> 00:16:50,780 +انميا فبالتالي موضوع الـ diagnosis إلها شوية شائق + +219 +00:16:50,780 --> 00:16:56,770 +هذي وبيغلب وإن شاء الله رب العالمين هنتعرف عليه هيك + +220 +00:16:56,770 --> 00:17:02,150 +بنكون مرينا على النوع الأول من أنواع الانيميا حسب + +221 +00:17:02,150 --> 00:17:05,290 +التقسيمة بتاعتنا احنا حكيانها الأنواع تلت أنواع + +222 +00:17:05,290 --> 00:17:10,910 +microcytic hypochromic microcytic normochromic و + +223 +00:17:10,910 --> 00:17:15,830 +normocytic normochromic هنبدأ نبلش مع بعض في النوع + +224 +00:17:15,830 --> 00:17:21,790 +التاني اللي هو macrocytic normochromic anemia في + +225 +00:17:21,790 --> 00:17:25,530 +هذا النوع لو جينا نشوف blood film هنشوف الخلايا + +226 +00:17:25,530 --> 00:17:30,910 +كلها خلايا macrocytic خلايا كبيرة مقارنة بنوعات ال + +227 +00:17:30,910 --> 00:17:34,330 +small lymphocyte ملاحظين في الـ blood film هذا كل + +228 +00:17:34,330 --> 00:17:41,110 +الخلايا عندي حجمها كبير طيب الخلاق اللي اللي هي ال + +229 +00:17:41,110 --> 00:17:45,030 +macrocytic anemia بتنقسم إلى نوعين نوع + +230 +00:17:45,030 --> 00:17:49,710 +megaloblastic anemia ونوع non megaloblastic anemia + +231 +00:17:50,450 --> 00:17:56,050 +الـ megaloblastic anemia عادة بتكون بسبب نقص إما + +232 +00:17:56,050 --> 00:18:00,770 +الـ vitamin B12 أو الفولات أو وجود خلل في + +233 +00:18:00,770 --> 00:18:05,690 +الميتابوليزم لإلهم الـ vitamin B12 و الفولات الـ + +234 +00:18:05,690 --> 00:18:08,510 +non megaloblastic anemia بتكونش بسبب نقص هذه + +235 +00:18:08,510 --> 00:18:13,950 +العناصر بتكون يعني بسبب أمراض تانية زي الـ liver + +236 +00:18:13,950 --> 00:18:19,320 +disease زي الـ alcoholism Post splenectomy زي حالات + +237 +00:18:19,320 --> 00:18:22,120 +neonatal macrocytosis لأن الـ reticulocyte بتكون + +238 +00:18:22,120 --> 00:18:25,880 +عالية عندهم stress arthritis برضه بسبب ارتفاع ال + +239 +00:18:25,880 --> 00:18:31,740 +reticulocyte الميجالوبلاستيك أنيميا الميجالوبلاستيك + +240 +00:18:31,740 --> 00:18:37,300 +أنيميا عادة بتكون بسبب نقص في زي ما قلنا + +241 +00:18:37,300 --> 00:18:41,460 +أحد العناصر الـ vitamin B12 أو الفوليك أسيد اللي هو + +242 +00:18:41,460 --> 00:18:48,260 +الفولات طبعا نقص أحد هذه العناصر بيؤدي إلى زيادة في + +243 +00:18:48,260 --> 00:18:53,140 +حجم الخلايا زيادة كبيرة في حجم الخلايا زي ما احنا + +244 +00:18:53,140 --> 00:18:58,920 +عارفين Vitamin B12 والفولات هدول اتنين مهمين في ال + +245 +00:18:58,920 --> 00:19:03,340 +DNA synthesis يعتبروا كـ coenzymes في الـ DNA + +246 +00:19:03,340 --> 00:19:08,440 +synthesis فإذا كان في نقص فيهم هنلاقي إنه في خلل + +247 +00:19:08,440 --> 00:19:14,290 +في عملية انقسام الخلية انقسام النواة بشكل أساسي يعني + +248 +00:19:14,290 --> 00:19:19,110 +هتصير إن النواة تكبر لكن لأنه في خلل في العناصر + +249 +00:19:19,110 --> 00:19:23,410 +اللي لازمة لانقسامها لن تنقسم النواة وبالتالي لن + +250 +00:19:23,410 --> 00:19:26,470 +نقسم الـ cytoplasm بعد ذلك الخلية هتطرد النواة + +251 +00:19:26,470 --> 00:19:30,210 +تاعتها ويظل عندي the cytoplasm double يعني هذا الـ + +252 +00:19:30,210 --> 00:19:33,510 +cytoplasm اللي عندي كان المفروض ينقسم بس لأن النوع + +253 +00:19:33,510 --> 00:19:38,210 +ما قدرتش تنقسم ما قدرش الـ cytoplasm ينقسم طبعا هذا + +254 +00:19:38,210 --> 00:19:43,530 +يؤدي إلى زي ما قلنا megaloplastic maturationالنوع + +255 +00:19:43,530 --> 00:19:49,270 +بتكبر كثير وبالتالي زي ما قلنا بيصير الـ nucleus + +256 +00:19:49,270 --> 00:19:52,050 +انقسم وبالتالي الـ cytoplasm ما بينقسم كثير عند + +257 +00:19:52,050 --> 00:19:58,570 +الخلية الكبيرة طبعا هذا بينتج عنه Enlarged Fragile + +258 +00:19:58,570 --> 00:20:04,690 +Cells يعني خلايا بتكون هشة وضعيفة معظم هذه الخلايا + +259 +00:20:04,690 --> 00:20:07,910 +أو الكثير منها بيموت في الـ bone marrow قبل ما يطلع + +260 +00:20:07,910 --> 00:20:11,280 +الـ Peripheral Bloodلأن الخلايا هذه بتكون non + +261 +00:20:11,280 --> 00:20:14,100 +-functional و fragile فبتم التخلص منها في الـ bone + +262 +00:20:14,100 --> 00:20:20,460 +marrow أو بتتكسر في الـ bone marrow طبعا سواء ال + +263 +00:20:20,460 --> 00:20:23,600 +vitamin B12 أو الـ folic acid deficiency الاثنين + +264 +00:20:23,600 --> 00:20:27,760 +بيعطوني نفس الـ blood picture يعني بيعطوني نفس ال + +265 +00:20:27,760 --> 00:20:32,140 +blood film و نفس الـ CBC في الـ Vitamin B12 + +266 +00:20:32,140 --> 00:20:36,520 +deficiency هنا بنلاحظ بعض الأعراض اللي لها علاقة + +267 +00:20:36,520 --> 00:20:43,000 +بالجهاز العصبي بتعمل بعض أعراض زي تنميل وخدران + +268 +00:20:43,000 --> 00:20:47,520 +وأشياء زي هيك طبعا وممكن تعمل nervousness هذا يعني + +269 +00:20:47,520 --> 00:20:51,060 +عادة إذا كانت الـ megaloplastic anemia مصاحبة لهذه + +270 +00:20:51,060 --> 00:20:59,060 +الأعراض بنشك أنه فيه نقص في Vitamin B12 طبعا لأن لو + +271 +00:20:59,060 --> 00:21:03,040 +أجينا هنا نقارن ما بين الـ maturation series في + +272 +00:21:03,040 --> 00:21:07,120 +الـ normal هي الـ normal plastic maturation مقارنة + +273 +00:21:07,120 --> 00:21:11,040 +بالـ megaloplastic maturation زي ما أنتم شايفين + +274 +00:21:11,040 --> 00:21:15,080 +كل الخلايا بتبدأ كبيرة و بتستمر بتظل حجمها كبير + +275 +00:21:15,080 --> 00:21:19,460 +لغاية ما تخرج للـ peripheral blood بينما ال + +276 +00:21:19,460 --> 00:21:22,400 +microcytic طبعا شفناها في الـ microcytic anemia + +277 +00:21:22,400 --> 00:21:25,720 +الخلايا بتبدأ صغيرة و بتطلع عندي microcytic cells + +278 +00:21:28,360 --> 00:21:32,680 +الآن نجي للـ lab finding في الـ megaloplastic anemia + +279 +00:21:32,680 --> 00:21:37,060 +ايش الأشياء اللي عندي بتبين في المختبر mild to + +280 +00:21:37,060 --> 00:21:42,840 +severe anemia بإيش بتتميز هذه الأنيميا طبعا الـ MCV + +281 +00:21:42,840 --> 00:21:48,020 +هيكون عالي الـ MCV عالي لأنه الخلايا كبيرة وده حجم + +282 +00:21:48,020 --> 00:21:56,240 +الخلية هيكون كبير الـ MCH عالي بينما الـ MCHC هيكون + +283 +00:21:56,240 --> 00:22:03,270 +normal طيب ليش الـ MCH عالي و الـ MCHC normal طبعا + +284 +00:22:03,270 --> 00:22:09,110 +الـ MCV لما بيكبر الخلية بتكبر بما فيها من محتوى + +285 +00:22:09,110 --> 00:22:13,770 +هيموجلوبين وإحنا إذا فاكرين أن الـ MCH هو عبارة + +286 +00:22:13,770 --> 00:22:18,290 +عن وزن الهيموجلوبين الموجودة داخل الخلية فبديهي + +287 +00:22:18,290 --> 00:22:22,150 +طالما الخلية كبرت هيزيد وزن الهيموجلوبين فيها + +288 +00:22:22,150 --> 00:22:27,610 +وبالتالي الـ MCH هيزيد لكن الـ MCHC زي ما أنتم + +289 +00:22:27,610 --> 00:22:31,510 +عارفين هو بيعبر عن نسبة الـ hemoglobin الموجودة في + +290 +00:22:31,510 --> 00:22:35,610 +الخلية هذا الـ hemoglobin صح هو وزنته كتيرة لكن + +291 +00:22:35,610 --> 00:22:40,170 +متناسب مع حجم الخلية يعني إحنا حقيقة الـ MCHC + +292 +00:22:40,170 --> 00:22:42,990 +بنجيب نسبة مئوية ما بين وزن الـ hemoglobin وحجم + +293 +00:22:42,990 --> 00:22:48,730 +الخلية فبالتالي طالما الاثنين كتروا الـ MCH و الـ + +294 +00:22:48,730 --> 00:22:54,160 +MCV هتكونوا الـ MCHC normal عشان هيك صنفناها إنها + +295 +00:22:54,160 --> 00:23:00,620 +normochromic أنيميا normochromic أنيميا الآن ال + +296 +00:23:00,620 --> 00:23:04,800 +parameters هنلاقي الـ RBCs الـ hemoglobin الـ white + +297 +00:23:04,800 --> 00:23:08,540 +blood cells البلايتليتس let's count كلها هذه ممكن نلاقيها لو + +298 +00:23:08,540 --> 00:23:13,000 +لأن الخلايا اللي بتتصنع في هذه الحالة هنلاقيها + +299 +00:23:13,000 --> 00:23:17,700 +fragile cells سهل إنه تتكسر في الـ bone marrow أو في أي + +300 +00:23:17,700 --> 00:23:22,140 +مكان طبعا الـ reticulocyte count هيكون قليل + +301 +00:23:24,460 --> 00:23:27,780 +Macrocytic Ovalocytes and Teardrops هذه أشياء + +302 +00:23:27,780 --> 00:23:30,480 +بشوفها في الـ Peripheral Blood بشوف Ovalocytes + +303 +00:23:30,480 --> 00:23:35,620 +كبيرة بشوف الـ Teardrop طبعا Marked Erythroid Exocytosis + +304 +00:23:35,620 --> 00:23:39,480 +and Pancytopenia ممكن أشوف Schistocytes أو + +305 +00:23:39,480 --> 00:23:43,380 +Microcytes ليش؟ لأن الخلايا أساسا زي ما قلنا fragile + +306 +00:23:43,380 --> 00:23:47,040 +و بتتكسر في الـ bone marrow فبالتالي ممكن أشوف قطعة منها + +307 +00:23:47,040 --> 00:23:52,130 +في الـ Peripheral Blood Erythroid Hyperplasia هنلاقي + +308 +00:23:52,130 --> 00:23:57,010 +إن شوية الـ erythroid بدأت ترتفع عندنا الـ Myeloid + +309 +00:23:57,010 --> 00:24:04,190 +Erythroid Ratio هتنزل الـ Iron Stores هتزيد لأنه + +310 +00:24:04,190 --> 00:24:07,090 +يعني المشكلة إن في نقص في الـ folic acid أو في الـ + +311 +00:24:07,090 --> 00:24:12,630 +Vitamin B12 فكل هذا هيأثر على إن خلايا ما بتتصنع + +312 +00:24:12,630 --> 00:24:16,590 +بشكل كويس في عندنا حديد زيادة الحديد هذا هيبلش + +313 +00:24:16,900 --> 00:24:19,800 +يتخزن يعني إذا ما قلنا دعوة في الحديد الحديد هنا + +314 +00:24:19,800 --> 00:24:22,980 +ما فيش فيه مشكلة والخلل في شيء تاني فبتاع الحديد + +315 +00:24:22,980 --> 00:24:26,220 +هيبدأ يزيد عن حاجة الجسم ويتجمع في الـ bone marrow + +316 +00:24:26,220 --> 00:24:31,260 +وفي الـ iron stores عندي هنا أكتر من الـ blood film + +317 +00:24:31,260 --> 00:24:35,520 +بيبين الحالات هذه بداية أول حاجة بدنا نلاحظ الحجم + +318 +00:24:35,520 --> 00:24:39,520 +تاع الخلايا الشكل تاع الخلايا في عندنا ovalocytes + +319 +00:24:39,520 --> 00:24:43,900 +زي ما أنتم شايفين ملحوظة إذا macrocytic ovalocytes + +320 +00:24:43,900 --> 00:24:50,820 +هيه هنا هنا عندنا الوجود nucleated RBCs ممكن أشوف + +321 +00:24:50,820 --> 00:24:54,940 +nucleated RBCs ممكن أشوف tear drop ممكن أشوف + +322 +00:24:54,940 --> 00:24:58,140 +schistocytes ممكن أشوف Howell Jolly bodies اللي هو عبارة + +323 +00:24:58,140 --> 00:25:03,620 +عن بقايا DNA الـ Howell Jolly bodies Basophilic stippling + +324 +00:25:03,620 --> 00:25:07,460 +ممكن أشوف giant platelets ممكن أشوف hyper + +325 +00:25:07,460 --> 00:25:13,500 +segmented bodies في عند هنا يعني حاجة بيعتبروها مميزة لحالات + +326 +00:25:13,500 --> 00:25:17,270 +الـ megaloplastic anemia اللي هي وجود hyper + +327 +00:25:17,270 --> 00:25:20,710 +-segmented neutrophils يعني هتلاقي الـ neutrophils + +328 +00:25:20,710 --> 00:25:26,290 +فيها hyper-segmentation الـ bone marrow عامة بيشتغل بأقل + +329 +00:25:26,290 --> 00:25:30,390 +من راحته بأقل من مهلة فبالتالي هتلاقي الخلايا + +330 +00:25:30,390 --> 00:25:37,010 +هيصير لها hyper-segmentation نيجي + +331 +00:25:37,010 --> 00:25:41,260 +لـ vitamin B12 deficiency الآن vitamin B12 + +332 +00:25:41,260 --> 00:25:44,000 +deficiency زي ما إحنا عارفين هو مهم جدا في تصنيع + +333 +00:25:44,000 --> 00:25:47,200 +الـ myelin شيء بتاع الخلايا العصبية فده صار فيه + +334 +00:25:47,200 --> 00:25:50,900 +deficiency من ضمن الأشياء إضافة للأنيميا بيصير + +335 +00:25:50,900 --> 00:25:54,940 +عنها أعراض عصبية زي ما حكينا طيب من .. من يعني من + +336 +00:25:54,940 --> 00:25:58,540 +ايش بيصير فيه deficiency؟ إما إنه خلل في كمية ال + +337 +00:25:58,540 --> 00:26:02,680 +vitamin B12 اللي بياخدها الإنسان أو خلل في امتصاصه + +338 +00:26:02,680 --> 00:26:07,630 +وفي الاستفادة منه في داخل الجسم أول حاجة يعني أول + +339 +00:26:07,630 --> 00:26:12,630 +الأسباب الـ nutritional deficiency أو أن الطعام + +340 +00:26:12,630 --> 00:26:16,070 +اللي بيتأخذ ما بيصير له proteolysis كويس في ال .. + +341 +00:26:16,070 --> 00:26:19,790 +في ال .. في الـ stomach وبالتالي ما بيطلعش vitamin + +342 +00:26:19,790 --> 00:26:24,070 +B12 بالطريقة اللي ممكن الجسم يستفيد منها loss or + +343 +00:26:24,070 --> 00:26:27,170 +atrophy of gastric mucosa يعني لو صار مشكلة في + +344 +00:26:27,170 --> 00:26:31,620 +المعدة في الـ gastric mucosa ممكن يصير Deficiency + +345 +00:26:31,620 --> 00:26:34,420 +في الـ Intrinsic Factor اللي هو بيرتبط مع الـ + +346 +00:26:34,420 --> 00:26:37,880 +Vitamin B12 وبيصير له امتصاص هناك فإذا كان فيه + +347 +00:26:37,880 --> 00:26:42,360 +نقص في الـ Intrinsic Factor هذا مش راح يصير امتصاص + +348 +00:26:42,360 --> 00:26:46,540 +لـ Vitamin B12 abnormal events in the small bowel + +349 +00:26:46,540 --> 00:26:49,480 +اليومين يعني فيه مشكلة في الأمعاء الدقيقة في الـ + +350 +00:26:49,480 --> 00:26:52,620 +small bowel ممكن تكون inadequate pancreatic + +351 +00:26:52,620 --> 00:26:56,080 +proteases كمية البروتياز الموجود في البنكرياس اللي + +352 +00:26:56,080 --> 00:26:59,800 +بيفرزه البنكرياس غير كافية competing agents like + +353 +00:26:59,800 --> 00:27:03,780 +فيشتاب وفوق worms ممكن هذا الأنواع من الـ deficiency + +354 +00:27:03,780 --> 00:27:08,300 +بتتنافس على هذا الـ vitamin وعلى الـ food بالنسبة + +355 +00:27:08,300 --> 00:27:12,180 +للفوليك الدفيشنسي أو الـ folic acid deficiency بالنسبة + +356 +00:27:12,180 --> 00:27:16,720 +للفوليك الدفيشنسي طبعا ممكن يكون بسبب deficient + +357 +00:27:16,720 --> 00:27:21,030 +intake مع الحاجة الزائدة له زي في حالات ال + +358 +00:27:21,030 --> 00:27:24,970 +pregnancy في حالات الأطفال في حالات زيادة ال + +359 +00:27:24,970 --> 00:27:28,750 +proliferation بتاع الخلايا في حالات الـ psoriasis + +360 +00:27:28,750 --> 00:27:34,530 +برضه يعني ممكن يكون صار له malabsorption ممكن يكون + +361 +00:27:34,530 --> 00:27:38,130 +بسبب congenital and drug-induced يعني أسباب يعني + +362 +00:27:38,130 --> 00:27:43,090 +عيوب خلقية أو بسبب بعض الأدوية ممكن يكون في خلل في + +363 +00:27:43,090 --> 00:27:48,430 +الـ metabolism بتاع الـ folate مثلا نقص ثيامين أو بعض + +364 +00:27:48,430 --> 00:27:51,570 +الأنزيمات المسؤولة عن تمثيل الـ folate + +365 +00:29:01,970 --> 00:29:07,010 +الـ Schilling test يستخدم لتشخيص الـ pernicious anemia + +366 +00:29:07,010 --> 00:29:10,890 +ونشوف يعني عشان نشوف ايش المشكلة اللي أدت لحدوث + +367 +00:29:10,890 --> 00:29:14,290 +نقص vitamin B12 أنا بروح بعطي المريض جرعة من + +368 +00:29:14,290 --> 00:29:18,770 +vitamin B12 وبتابع الجرعة هذه الآن إذا ظهرت في ال + +369 +00:29:18,770 --> 00:29:23,930 +urine بعد الكلام إنه المريض ما عندهوش مشكلة وإنما + +370 +00:29:23,930 --> 00:29:28,390 +مشكلته كانت في نقص malnutrition يعني مشكلته + +371 +00:29:28,390 --> 00:29:31,540 +nutritional deficiency يعني ما عنده مشكلة في ال + +372 +00:29:31,540 --> 00:29:36,340 +absorption لكن لو ما ظهرت في الـ urine بروح بعطي + +373 +00:29:36,340 --> 00:29:40,760 +المرحلة الثانية بعطي مع الـ vitamin B12 intrinsic + +374 +00:29:40,760 --> 00:29:45,740 +factor هلاقي إذا كان بعد ما أعطيت الـ intrinsic + +375 +00:29:45,740 --> 00:29:49,340 +factor ظهر الـ vitamin B12 اللي أنا أعطيته في الـ +urine + +376 +00:29:49,340 --> 00:29:52,480 +urine معنى الكلام إنه المشكلة في الـ intrinsic + +377 +00:29:52,480 --> 00:29:57,780 +factor ولما أنا دخلته انحلت المشكلة لكن لو ما ظهر + +378 +00:29:57,780 --> 00:30:00,440 +بالـ urine بنخش على المرحلة اللي بعدها اللي هي + +379 +00:30:00,440 --> 00:30:03,720 +المرحلة الثالثة بيكون في احتمال بشوف إذا كان في + +380 +00:30:03,720 --> 00:30:07,420 +مشكلة في الـ intestine أو في الـ pancreas تمام هذا + +381 +00:30:07,420 --> 00:30:11,640 +يعني فترة بسيطة عن shelling test نجي إلى non + +382 +00:30:11,640 --> 00:30:16,580 +megaloplastic anemia هنا بتكون المشكلة أن الخلايا + +383 +00:30:16,580 --> 00:30:21,380 +كبيرة بس مش بسبب نقص الـ vitamin B12 أو الفولات + +384 +00:30:21,380 --> 00:30:26,950 +عادةً يعني أهم الأسباب شيوعًا أنه في اندي + +385 +00:30:26,950 --> 00:30:30,150 +accelerated erythropoiesis يعني الـ bone marrow بيشتغل + +386 +00:30:30,150 --> 00:30:33,610 +تحت stress فبالتالي بيطلع عندي الـ reticulocyte هيها + +387 +00:30:33,610 --> 00:30:38,290 +مبينة هنا في الـ V في الصورة خلايا أكبر من الطبيعي + +388 +00:30:38,290 --> 00:30:41,390 +بشوية ولونها واخد اللون ما بين الـ pink للـ blue + +389 +00:30:41,390 --> 00:30:48,550 +طبعًا هذه بتؤدي إلى ارتفاع الـ MCV في الحالات الأخرى + +390 +00:30:48,550 --> 00:30:51,270 +أيضًا اللي هي liver disease and alcoholism هنا + +391 +00:30:51,270 --> 00:30:54,250 +بيصير عندهم درجة من الأنيميا بلاقي عندهم round + +392 +00:30:54,250 --> 00:30:58,850 +macrocytosis بلاقي عندهم poikilocytosis يعني ممكن + +393 +00:30:58,850 --> 00:31:02,430 +أشوف target cell أكانثوسيت ممكن أشوف إيكينوسيت + +394 +00:31:02,430 --> 00:31:07,310 +طبعًا لأنه بيبقى في عندهم نقص في الـ lipid أو مشكلة + +395 +00:31:07,310 --> 00:31:10,190 +في الـ lipid metabolism طبعًا الـ lipid مهمة جدًا في + +396 +00:31:10,190 --> 00:31:13,630 +cell membrane فبالتالي إذا كان فيها deficiency هذا + +397 +00:31:13,630 --> 00:31:17,250 +بيؤدي إلى إن الـ cell membrane ما بتكون بشكل + +398 +00:31:17,250 --> 00:31:20,590 +طبيعي فبتظهر عندي الـ acanthocyte و الـ echinocyte + +399 +00:31:20,590 --> 00:31:26,130 +و الأشكال الأخرى من الخلايا نيجي + +400 +00:31:26,130 --> 00:31:29,270 +للـ differential diagnosis كيف نميز أنواع الأنيميا + +401 +00:31:29,270 --> 00:31:32,290 +هل هي megaloplastic ولا non-megaloplastic بنعمل + +402 +00:31:32,290 --> 00:31:36,990 +vitamin B12 و الـ folate level ممكن بعض الحاجات + +403 +00:31:36,990 --> 00:31:40,690 +تكون مميزة لـ megaloplastic anemia زي وجود الـ + +404 +00:31:40,690 --> 00:31:44,570 +hyper-segmented neutrophil وبرضه بعض الـ morphology + +405 +00:31:44,570 --> 00:31:49,270 +الأخرى اللي ممكن تدلل يعني لو عملنا لو لاحظنا في + +406 +00:31:49,270 --> 00:31:51,710 +الـ blood film اللي هو فيه macrocytosis اللي هي non + +407 +00:31:51,710 --> 00:31:55,410 +-megaloplastic مثلًا هلاحظ فيه اللي هي الـ + +408 +00:31:55,410 --> 00:31:57,910 +polychromasia اللي هي الـ reticulocyte بعدد كبير + +409 +00:31:57,910 --> 00:32:00,530 +بينما هنا مابتكونش موجودة في الـ megaloplastic + +410 +00:32:00,530 --> 00:32:05,170 +أنيميا على سبيل المثال برضه لو كانت حالة liver + +411 +00:32:05,170 --> 00:32:08,530 +disease هنلاقي تغير في أشكال الخلايا اللي هي راجع + +412 +00:32:08,530 --> 00:32:10,870 +على خلال في الـ cell membrane زي الـ acanthocyte أو الـ + +413 +00:32:11,980 --> 00:32:12,400 +وهكذا diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..c8e512d361500a7c46e72c371e5f29c25bb952b4 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo_postprocess.srt @@ -0,0 +1,1652 @@ +1 +00:00:01,690 --> 00:00:06,950 +الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبابتتقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +التلاتة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش أني أحفظ إيش تعريف الانيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش ال pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط النتائج هذه مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مصاحبة لهذا ال result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات عشان أتأكد من ال results معينة هذا + +20 +00:01:32,370 --> 00:01:36,270 +الكلام بإذن الله كله راح نناقشه مع بعض شويه شويه + +21 +00:01:36,270 --> 00:01:37,690 +أول حاجة هنشرحه بعد + +22 +00:01:53,930 --> 00:01:58,290 +الخلل هذا طبعاً بيكون خلل في الـ Alpha أو في الـ + +23 +00:01:58,290 --> 00:02:04,050 +Beta-H-chain خلايا عادة بتكون hypochromic + +24 +00:02:04,050 --> 00:02:08,310 +microcytic cells طبعاً بتتميز وجود كمية من ال + +25 +00:02:08,310 --> 00:02:13,450 +target cells فيها genetic mutation specified by + +26 +00:02:13,450 --> 00:02:16,530 +يعني ال mutation فيها قد تكون في الـ Beta-H-chain + +27 +00:02:16,790 --> 00:02:19,350 +وقد تكون في الـ Alpha Chain إذا كان نقص في الـ + +28 +00:02:19,350 --> 00:02:22,410 +Beta Chain نقص في تصنيع الـ Beta Chain بسميها Beta + +29 +00:02:22,410 --> 00:02:25,410 +-thalassemia وهذه شائعة في اليونان وفي إيطاليا إذا + +30 +00:02:25,410 --> 00:02:27,890 +كان نقص في الـ Alpha Chain بسميها Alpha + +31 +00:02:27,890 --> 00:02:31,510 +-thalassemia طبعا احنا عارفين الـ Hemoglobin + +32 +00:02:31,510 --> 00:02:35,610 +Molecule Hemoglobin Molecule أربعة إجلوبين Chain + +33 +00:02:35,610 --> 00:02:40,110 +وأربعة هيم إجروبهي Hemoglobin chain مثلا هي + +34 +00:02:40,110 --> 00:02:44,430 +Hemoglobin molecule العادي بيكون فيه هي Hem Hem + +35 +00:02:44,430 --> 00:02:48,750 +Hem أربع Hem وفي عنده ال globin ال globin بتكون من + +36 +00:02:48,750 --> 00:02:52,130 +two alpha و two beta chain في ال adult ال normal + +37 +00:02:52,130 --> 00:02:58,650 +هلاقي 97% من ال hemoglobin Hemoglobin Aبنلاقي نسبة + +38 +00:02:58,650 --> 00:03:03,030 +بسيطة من Hemoglobin A2 بتشكل 2% A2 بتكون من 2 + +39 +00:03:03,030 --> 00:03:07,590 +Alpha مع 2 Delta Hemoglobin F بتشكل برضه نسبة + +40 +00:03:07,590 --> 00:03:12,130 +بسيطة تقريبا 1% أو أقل تنتين Gamma وتنتين Alpha + +41 +00:03:12,130 --> 00:03:14,970 +يعني التلاتة بيشتركوا في وجود Alpha اتشان زي ما + +42 +00:03:14,970 --> 00:03:15,610 +انتوا شايفين + +43 +00:04:56,960 --> 00:05:01,040 +الكيميا زى ما انتوا عارفين قد تكون lethal وقد تكون + +44 +00:05:01,040 --> 00:05:06,280 +يعني مرضى بيعتمدوا على transfusion بشكل مستمر يعني + +45 +00:05:06,280 --> 00:05:11,580 +عايشين على blood transfusion أو بدون أي symptoms + +46 +00:05:11,580 --> 00:05:14,640 +يعني بيكونوا عايشين حياتهم طبيعية وده بيعتمد على + +47 +00:05:14,640 --> 00:05:18,580 +عدد الجينات اللى اتأثرت وبالتالي عدد ال chains + +48 +00:05:18,580 --> 00:05:22,580 +اللى اتأثرت في ال hemoglobin طبعا ال majorالـ + +49 +00:05:22,580 --> 00:05:26,420 +major زي ما انتوا عارفين بيصير خلل كله في الـ + +50 +00:05:26,420 --> 00:05:29,460 +chain يعني مافيش Alpha ولا فيه Beta يا اما مافيش + +51 +00:05:29,460 --> 00:05:32,580 +Beta خالص فبالتالي الـ hemoglobin الطبيعي مش راح + +52 +00:05:32,580 --> 00:05:36,240 +يتصنع الـ alpha chain للـ hemoglobinالـ Minor + +53 +00:05:36,240 --> 00:05:41,260 +بيبقى فيه خلل في مثلا واحدة Alpha خلل في واحدة + +54 +00:05:41,260 --> 00:05:47,560 +Beta فبالتالي بيصير نفس بسيط في نقص معين أو بسيط + +55 +00:05:47,560 --> 00:05:51,640 +في نوع الـ Hemoglobin حسب الخلل اللي صار بيصير خلل + +56 +00:05:51,640 --> 00:05:56,940 +في تصنيع الـ Beta Chain وبالتالي بيصير عندناهنيجي + +57 +00:05:56,940 --> 00:05:59,840 +للـ Beta-thalassemia major، homozygous هنا بيبقى + +58 +00:05:59,840 --> 00:06:03,700 +في الـ Beta-charritin تان الـ gene تبعهم ضارب، + +59 +00:06:03,700 --> 00:06:07,260 +خربان يعني مافيش عندي Beta-chain خالص هدول المرضى + +60 +00:06:07,260 --> 00:06:11,280 +بيعتمدوا بشكل أساسي على blood transfusion بتلاقي + +61 +00:06:11,280 --> 00:06:14,800 +الـ RBCs بتصير rigid ليش؟ لأنه فيها hen's body هذه + +62 +00:06:14,800 --> 00:06:17,540 +الـ hen's body من وين أجت من تراكم الـ Alpha-chain + +63 +00:06:17,540 --> 00:06:22,590 +لزيادة وطبعا هذا بيؤدي لتكسير الخلايابقدّي لتكسير + +64 +00:06:22,590 --> 00:06:26,190 +الخلايا هاي هنا عندنا صورة بتوضّح تراكم الـ hens + +65 +00:06:26,190 --> 00:06:31,670 +bodies في الخلايا طبعا أي خلية فيها hens body حتى + +66 +00:06:31,670 --> 00:06:38,410 +تاخدها الماكروفاج وتعملها طيب + +67 +00:06:38,410 --> 00:06:42,430 +ال lab finding عند هدول الناس severe anemia بلاقي + +68 +00:06:42,430 --> 00:06:46,570 +target cells بشكل كتير كبيربلاق الـ Nucleated RBCs + +69 +00:06:46,570 --> 00:06:49,730 +لأنه تكسير فبالتالي البون مارو بده يعود فبلاق الـ + +70 +00:06:49,730 --> 00:06:52,950 +Nucleated RBCs برضه الـ reticulocyte بتكون عالية + +71 +00:06:52,950 --> 00:06:56,910 +هيهد الـ Nucleated RBCs إذا فاكرينها بلاق الـ + +72 +00:06:56,910 --> 00:06:59,490 +Inclusion Bodies زي الـ Basophilic Stippling اللي + +73 +00:06:59,490 --> 00:07:02,850 +هي بتكون نقاط من الريبوزومة الـ RNA في الخلية + +74 +00:07:02,850 --> 00:07:07,290 +مابلققيش عندهم خالص Hemoglobin A وإنما تم استيعاضه + +75 +00:07:07,290 --> 00:07:10,590 +بالـ Gamma Channel Beta Channel ضربت تصنع بدلها + +76 +00:07:10,590 --> 00:07:15,360 +Gamma Channel وصار عندهم Hemoglobin Fبكمية كبيرة + +77 +00:07:15,360 --> 00:07:19,880 +طبعاً + +78 +00:07:19,880 --> 00:07:23,980 +علاجهم الـ Transfusion اسمه Linectomy-oil + +79 +00:07:23,980 --> 00:07:28,980 +-chelating agent هاي Blood Film فيه Nucleated RBC + +80 +00:07:28,980 --> 00:07:34,340 +فيبنهايمر Bodies فيه يعني هنا مقشر حاجة لطيفة مقشر + +81 +00:07:34,340 --> 00:07:39,600 +هنا على RBC عثية وكويسة يعني هذه عادة بتكون من ال + +82 +00:07:39,600 --> 00:07:44,370 +Blood Transfusionتمام hypercellular bone marrow + +83 +00:07:44,370 --> 00:07:48,630 +نيجي + +84 +00:07:48,630 --> 00:07:54,390 +للـ Beta-thalassemia minor طبعا هنا بيكون ال beta + +85 +00:07:54,390 --> 00:07:58,370 +chain واحدة فيهم فيها مشكلة أو واحدة فيها طبيعية + +86 +00:07:58,370 --> 00:08:02,670 +فبالتالي بيصير نقص في تصنيع ال beta chain لكن مش + +87 +00:08:02,670 --> 00:08:06,370 +انعدامممكن ألاقي الـ blood picture زي الشخص + +88 +00:08:06,370 --> 00:08:10,370 +الطبيعي وحتى يعني لو ما دور حاله او ماشكش انه عنده + +89 +00:08:10,370 --> 00:08:13,490 +beta-thalassemia وراح دور حاله ممكن مايعرفش، بتكون + +90 +00:08:13,490 --> 00:08:17,590 +أنيميا mild ممكن ألاقي بعض ال target cell، + +91 +00:08:17,590 --> 00:08:20,710 +مابلاقيش الـ nucleated RBCs ممكن أشوف basophilic + +92 +00:08:20,710 --> 00:08:24,730 +stippling، hence bodies مافيش، serum iron بيكون + +93 +00:08:24,730 --> 00:08:30,830 +طبيعي، حلاقي هنا عندهم زيادة في hemoglobin A نيجي + +94 +00:08:30,830 --> 00:08:35,240 +للـ alpha-thalassemiaالألفا ثلاثيميا زي ما انتوا + +95 +00:08:35,240 --> 00:08:40,220 +عارفين في عندي أربع جينات طبعا اللي مسئولة عن الـ + +96 +00:08:40,220 --> 00:08:45,020 +Alpha Chain أحيانا بيبقى الأربع جينات ضاربين + +97 +00:08:45,020 --> 00:08:49,220 +فبالتالي مافيش عندنا Alpha Chain خالص بتتصنع طبعا + +98 +00:08:49,220 --> 00:08:54,360 +هذا يعني بنشأ طفل يعني بيموت Hydrops Fetalis + +99 +00:08:54,360 --> 00:08:59,660 +مابيقدرش يكمل بسميها طبعا Alpha Thalassemia Major + +100 +00:08:59,660 --> 00:09:04,960 +Hemozygous مافيش عندنا Alpha Chainالنوع التاني + +101 +00:09:04,960 --> 00:09:09,260 +اللي هو الـ Alpha-thalassemia intermediate الـ + +102 +00:09:09,260 --> 00:09:13,180 +Alpha-thalassemia intermediate عادةً بيكونوا تلاتة + +103 +00:09:13,180 --> 00:09:16,380 +من الجينات اتأثروا أو صارلهم deletion هنا بيصير + +104 +00:09:16,380 --> 00:09:20,480 +moderate decrease in Alpha-chain synthesis طبعاً + +105 +00:09:20,480 --> 00:09:24,420 +بيصير زيادة في الـ Beta-chain بنشأ عنها أنص stable + +106 +00:09:24,420 --> 00:09:26,920 +hemoglobin H اللي هو بتكون من أربعة Beta-chain + +107 +00:09:26,920 --> 00:09:33,150 +وبيعمل ترسيب في الخلية على شكل hen's bodyطبعاً هذا + +108 +00:09:33,150 --> 00:09:37,210 +هيصير لوضوع تلاثيميا + +109 +00:09:37,210 --> 00:09:41,370 +minor طبعاً بيكون هنا dilation لواحد أو تنين من + +110 +00:09:41,370 --> 00:09:45,770 +الـ alpha chain احنا قولنا ال major أربعة ال + +111 +00:09:45,770 --> 00:09:49,430 +intermediate تلاتة هنا اتنين او واحد هنا بيصير + +112 +00:09:49,430 --> 00:09:52,870 +slight decrease in alpha chain production mild or + +113 +00:09:52,870 --> 00:09:56,010 +no anemia بنلاقي فيها بعض ال target cells + +114 +00:09:56,290 --> 00:10:00,430 +Essentially Normal Electrophoresis ممكن ما نقدرش + +115 +00:10:00,430 --> 00:10:03,490 +نعمل لها diagnosis وتعدي يعني تكون ال + +116 +00:10:03,490 --> 00:10:05,970 +Electrophoresis هي ال Normal هذا ال Normal + +117 +00:10:05,970 --> 00:10:08,750 +Electrophoresis ال Beta-thalassemia major لأن + +118 +00:10:08,750 --> 00:10:12,470 +هموجلب ال F هو اللي برتفع Beta-thalassemia minor + +119 +00:10:12,470 --> 00:10:15,830 +بتلاقي ارتفاع شوية في هموجلب ال A2 ال Alpha + +120 +00:10:15,830 --> 00:10:19,670 +-thalassemia هتلاقيها تقريبا ال Alpha-thalassemia + +121 +00:10:19,670 --> 00:10:23,710 +major هذه هتلاقي انه في complete absence لل + +122 +00:10:25,340 --> 00:10:28,380 +الهيموجلبين ايه فبالتالي هيتكون انتي بارد بارد + +123 +00:10:28,380 --> 00:10:33,580 +هيموجلبين البارد هيموجلبين طبعا هذه قولنا عن + +124 +00:10:33,580 --> 00:10:37,100 +hydrophs fetalis بس انا هنا بدي اقولكم كمان في ال + +125 +00:10:37,100 --> 00:10:39,640 +alpha-thalassemia intermediate هنلاقي ال alpha + +126 +00:10:39,640 --> 00:10:42,700 +-thalassemia minor هنلاقي ال electrophoresis لإلها + +127 +00:10:42,700 --> 00:10:44,720 +زي و زي ال normal electrophoresis + +128 +00:10:47,960 --> 00:10:51,840 +بالكلام اللي حكيناه بس أنا بدي أورجيكم نسب الـ + +129 +00:10:51,840 --> 00:10:54,500 +Hemoglobin في كل حالة يعني عند الـ Beta + +130 +00:10:54,500 --> 00:10:57,940 +-thalassemia في عند الـ homozygous هنلاقي + +131 +00:10:57,940 --> 00:11:02,560 +Hemoglobin F من 40 إلى 90% في الـ Beta-thalassemia + +132 +00:11:02,560 --> 00:11:07,760 +minor هنلاقي Hemoglobin A2 هو الارتفاع بس برضه مش + +133 +00:11:07,760 --> 00:11:14,240 +هيرتفع كتير من 3.5 إلى 7% Hemoglobin F هتلاقيه + +134 +00:11:14,240 --> 00:11:16,320 +normal في 50% من الحالات + +135 +00:11:19,280 --> 00:11:22,520 +بالنسبة للـ Alpha-thalassemia الـ homozygous الـ + +136 +00:11:22,520 --> 00:11:26,860 +major هنلاقي hemoglobin parts بشكل 80% في الـ cord + +137 +00:11:26,860 --> 00:11:32,530 +bloodطبعا بعد هيك تيجي عند الـ Intermediate هتلاقي + +138 +00:11:32,530 --> 00:11:37,190 +Hemoglobin H نسبته من 4 إلى 30% unstable or non + +139 +00:11:37,190 --> 00:11:39,730 +-functional بسيروتكسير الـ Alpha-thalassemia + +140 +00:11:39,730 --> 00:11:43,730 +heterozygous هتلاقي فيها Hemoglobin parts من 1 إلى + +141 +00:11:43,730 --> 00:11:48,610 +10% في ال cord blood مش في الأدل طبعا Hemoglobin H + +142 +00:11:48,610 --> 00:11:52,770 +نادر لما نشوفه في ال cord bloodوالـ Hemoglobin A + +143 +00:11:52,770 --> 00:11:55,710 +تقريباً هيكون فيه slight decrease و البقية النامية + +144 +00:11:55,710 --> 00:11:58,490 +هيكون ال profile بتاعها زي و زي ال normal + +145 +00:11:58,490 --> 00:12:03,750 +Hemoglobin Electro في كل شيء + +146 +00:12:03,750 --> 00:12:08,250 +هنا + +147 +00:12:08,250 --> 00:12:11,530 +يعني عمللي differential diagnosis بين الأنواع + +148 +00:12:11,530 --> 00:12:16,710 +المختلفة لـmicrocytic anemia اللي هم ال beta + +149 +00:12:16,710 --> 00:12:19,050 +-thalassemia و ال alpha-thalassemia ال + +150 +00:12:19,050 --> 00:12:24,150 +cideroplastic و ال iron deficiencyهنا طبعا مش ذاكر + +151 +00:12:24,150 --> 00:12:27,390 +الـ CPC لأن الـ CPC أنا بلزمني بس عشان أفرق بين + +152 +00:12:27,390 --> 00:12:31,310 +الثلاثيميا والـ Iron deficiency تمام الـ CPC + +153 +00:12:31,310 --> 00:12:34,970 +تقريبا بتلاقي يعني الـ blood indices والأشياء هذه + +154 +00:12:34,970 --> 00:12:40,310 +متشابهة فيهم كلهم إلا بعض الفرقات هناخدها بالشريحة + +155 +00:12:40,310 --> 00:12:46,450 +التالية اللي بعدها طيب نيجي أول حاجة في الـ Iron + +156 +00:12:46,450 --> 00:12:52,670 +deficiency anemia serum iron level هينقصبديهي + +157 +00:12:52,670 --> 00:12:56,590 +تمام؟ والـ Total Iron Binding Capacity هتزيد + +158 +00:12:56,590 --> 00:13:00,550 +والفيريتين هينقص عكسها تماما الـ Cedroplastic + +159 +00:13:00,550 --> 00:13:04,630 +Anemia زيادة الحديد نقص الـ Total Iron Binding + +160 +00:13:04,630 --> 00:13:10,850 +Capacity زيادة الفيريتين تمام هيك؟ الثلاثيميا + +161 +00:13:10,850 --> 00:13:14,270 +مالهاش دعوة في الحديد نيجي للـ Hemoglobin + +162 +00:13:14,270 --> 00:13:16,790 +Electrophoresis في الـ Iron Deficiency Anemia + +163 +00:13:16,790 --> 00:13:20,830 +مافيش خلل في الـ Hemoglobin يعني هيكون Normalفي + +164 +00:13:20,830 --> 00:13:24,090 +الـ Beta-thalassemia حيصير زيادة في Hemoglobin A2 + +165 +00:13:24,090 --> 00:13:27,310 +Alpha-thalassemia Hemoglobin A2 هيكون normal في + +166 +00:13:27,310 --> 00:13:29,590 +السدر بلاستيك أنيميا هيكون normal يعني المشكلة وين + +167 +00:13:29,590 --> 00:13:33,590 +في الـ Beta-thalassemia هيكون في زيادة هذه أشياء + +168 +00:13:33,590 --> 00:13:37,450 +يعني مش شرط يعني مش بقياس كتير يعني زي مثلًا + +169 +00:13:37,450 --> 00:13:40,310 +Basophilic Stabling أكيد بتوجدش في الـIron في شنصي + +170 +00:13:40,310 --> 00:13:43,290 +أنيميا لكن ممكن توجد في الأنواع التانية فبنهاي + +171 +00:13:43,290 --> 00:13:48,070 +ممكن تجيزي لأكتر حاجتين بغلبونا في التشخيص الصحيح + +172 +00:13:48,560 --> 00:13:52,060 +وهناخد عليهم cases كتير ونطبق بإذن الله اللي هم + +173 +00:13:52,060 --> 00:13:54,780 +الـ Iron deficient cyanemia والثلاثيميا خاصة طبعا + +174 +00:13:54,780 --> 00:13:58,420 +الـ Thalassemia trait في عندي بعض الأشياء بدي + +175 +00:13:58,420 --> 00:14:02,840 +ألاحظ يعني أفرق بينهم خليني يعني أشوف المنذر index + +176 +00:14:02,840 --> 00:14:08,620 +هذا عادة MCV على RBCs أقل من 13 في الثلاثيميا يعني + +177 +00:14:08,620 --> 00:14:14,120 +احنا يعني ممكن نلاقي حالة مش ثابتة معها الكريتيريا + +178 +00:14:14,120 --> 00:14:18,590 +هذه كلهافبنضطر نضيف فحصات تانية أو حتى يعني نعمل + +179 +00:14:18,590 --> 00:14:22,630 +Hemoglobin A2 and so on يعني الـCBC لوحده يعني + +180 +00:14:22,630 --> 00:14:25,630 +مابيعطناش diagnosis نهائي للثلاثيميا والـIron + +181 +00:14:25,630 --> 00:14:28,350 +Deficiency يعني مافي بعض الحالات بتكون واضحة وفي + +182 +00:14:28,350 --> 00:14:32,550 +حالات بتكون بين بين وممكن نلجأ لهemoglobin A2 أو + +183 +00:14:32,550 --> 00:14:35,310 +Hemoglobin A2 أو فحص الـelectrophoresis عشان + +184 +00:14:35,310 --> 00:14:40,950 +نميزهم عن بعض طيب نيجي للـRBCs الـRBCs هي بنادسة + +185 +00:14:40,950 --> 00:14:44,700 +الثلاثيميا بتكون عالية ليش؟بأن الـ bone marrow + +186 +00:14:44,700 --> 00:14:48,100 +بيكون hypercellular يعني بيبقى فيه تكسير وبالتالي + +187 +00:14:48,100 --> 00:14:52,460 +فيه تصنيع أكتر فبالتالي هتلاقي RBCs كتير على خلاف + +188 +00:14:52,460 --> 00:14:54,960 +الـ Iron deficiency أنيمية عادة الـ RBCs فيها + +189 +00:14:54,960 --> 00:14:58,840 +قليلة الـ Thalassemia بتلاقي الـ RBCs فيها فوق + +190 +00:14:58,840 --> 00:15:01,920 +الخمسة بينما الـ Iron deficiency أقل من خمسة أو + +191 +00:15:01,920 --> 00:15:08,230 +أقل من أربع كمان يعني الـ MCV عادةأقل من 70 في الـ + +192 +00:15:08,230 --> 00:15:10,470 +Thalassemia trait و أكتر من 70 في الـ Iron + +193 +00:15:10,470 --> 00:15:12,310 +deficiency anemia يعني قد ما بنقص في الـ Iron + +194 +00:15:12,310 --> 00:15:15,250 +deficiency anemia وإن كان ممكن ينقص عن 70 يعني في + +195 +00:15:15,250 --> 00:15:20,250 +حالتها نشوفها في Iron deficiency أقل من 70 Red + +196 +00:15:20,250 --> 00:15:23,270 +distribution with RDW في الـ Iron deficiency + +197 +00:15:23,270 --> 00:15:27,930 +anemia بتلاقي عالي هو هد عبارة عن إيش الـ RDW الـ + +198 +00:15:27,930 --> 00:15:33,440 +RDW هو مقدار الـ variation بين أحجام الخلايامقدار + +199 +00:15:33,440 --> 00:15:37,420 +الـ variation بين أحجام الخلايا يعني بيدل على إنه + +200 +00:15:37,420 --> 00:15:40,600 +في عندك كام population من الخلايا الـ Iron + +201 +00:15:40,600 --> 00:15:44,500 +deficiency عادة مش قلتلكم إنه بتمر بمراحل يعني في + +202 +00:15:44,500 --> 00:15:47,480 +stage 1 و stage 2 و stage 3 فبالتالي مش هتلاقي كل + +203 +00:15:47,480 --> 00:15:52,480 +الخلايا نفس ال stage في خلايا نقص عليها الحديد وفي + +204 +00:15:52,480 --> 00:15:56,220 +خلايا لسه كويسة وعمر الخلايا 120 يوم فبالتالي + +205 +00:15:56,220 --> 00:15:58,540 +هنلاقي فيه تباين في أحجام الخلايا في الـ Iron + +206 +00:15:58,540 --> 00:16:02,340 +deficiency برتفع الـ RDWبينما في الثلاثيميا + +207 +00:16:02,340 --> 00:16:07,500 +بتلاقيها كلها صغيرة زي بعض هتلاقي الـ RDW أقل من + +208 +00:16:07,500 --> 00:16:13,620 +17% تمام؟ و هذا الكلام يعني هنحكي فيه أكتر من هك و + +209 +00:16:13,620 --> 00:16:18,080 +هنحاول نجيب علاقات يعني أشياء معينة من خلال الـ + +210 +00:16:18,080 --> 00:16:22,760 +CPC نربط بينها و نحاول نعرف الحالة إذا كانت Iron + +211 +00:16:22,760 --> 00:16:25,120 +deficiency anemia أو لا ثلاثيميا عند التطبيق يعني + +212 +00:16:25,120 --> 00:16:29,500 +بيكون أهم لأن أحيانًا بيصير تداخلومابتلاقيش يعني + +213 +00:16:29,500 --> 00:16:32,080 +مابتلاقيش خط فاصل هي ثلاثيميا ولا iron deficiency + +214 +00:16:32,080 --> 00:16:35,700 +انميا فبنصير نرجح يعني بتلاقي كل مثلا ال criteria + +215 +00:16:35,700 --> 00:16:40,500 +بتقول انها ثلاثيميا لكن بتلاقي ال RDW عالي طب ايش + +216 +00:16:40,500 --> 00:16:44,400 +هي؟ طب هي ممكن تكون ثلاثيميا ودخلت على خط ال iron + +217 +00:16:44,400 --> 00:16:47,380 +deficiency صارت ثلاثيميا مركبة على iron deficiency + +218 +00:16:47,380 --> 00:16:50,780 +انميا فبتتالي موضوع ال diagnosis إلها شوية شائق + +219 +00:16:50,780 --> 00:16:56,770 +هادي وبيغلب وإن شاء الله رب العالمين هنتعرف عليههك + +220 +00:16:56,770 --> 00:17:02,150 +بنكون مرينا على النوع الأول من أنواع الانيميا حسب + +221 +00:17:02,150 --> 00:17:05,290 +التقسيمة بتاعتنا احنا حكيانها الأنواع تلت أنواع + +222 +00:17:05,290 --> 00:17:10,910 +microcytic hypochromic microcytic normochromic و + +223 +00:17:10,910 --> 00:17:15,830 +normocytic normochromic هنبدأ نبلش مع بعض في النوع + +224 +00:17:15,830 --> 00:17:21,790 +التاني اللي هو macrocytic normochromic anemiaفي + +225 +00:17:21,790 --> 00:17:25,530 +هذا النوع لو جينا نشوف blood film هنشوف الخلايا + +226 +00:17:25,530 --> 00:17:30,910 +كلها خلايا macrocytic خلايا كبيرة مقارنة بنوعات ال + +227 +00:17:30,910 --> 00:17:34,330 +small lymphocyte ملاحظين في ال blood film هذا كل + +228 +00:17:34,330 --> 00:17:41,110 +الخلايا عندى حجمها كبير طيب الخلاق اللى اللى هى ال + +229 +00:17:41,110 --> 00:17:45,030 +macrocytic anemia بتنقسم إلى نوعين نوع + +230 +00:17:45,030 --> 00:17:49,710 +megaloplastic anemia ونوع non megaloplastic anemia + +231 +00:17:50,450 --> 00:17:56,050 +الـ megaloplastic anemia عادة بتكون بسبب نقص إما + +232 +00:17:56,050 --> 00:18:00,770 +الـ vitamin B12 أو الفولات أو وجود خلل في + +233 +00:18:00,770 --> 00:18:05,690 +الميتابوليزم لإلهم الـ vitamin B12 و الفولات الـ + +234 +00:18:05,690 --> 00:18:08,510 +non megaloplastic anemia بتكونش بسبب نقص هذه + +235 +00:18:08,510 --> 00:18:13,950 +العناصر بتكون يعني بسبب أمراض تانية زي ال liver + +236 +00:18:13,950 --> 00:18:19,320 +disease زي ال alcoholismPost splenectomy زي حالات + +237 +00:18:19,320 --> 00:18:22,120 +neonatal macrocytosis لأن ال reticulocyte بتكون + +238 +00:18:22,120 --> 00:18:25,880 +عالية عندهم stress arthritis برضه بسبب ارتفاع ال + +239 +00:18:25,880 --> 00:18:31,740 +reticulocyte الميجالو بلاستيك أنيميا الميجالو + +240 +00:18:31,740 --> 00:18:37,300 +بلاستيك أنيميا عادة بتكون بسبب نقص في زي ما قلنا + +241 +00:18:37,300 --> 00:18:41,460 +أحد العناصر ال vitamin B12 أو الفولك أسد اللي هو + +242 +00:18:41,460 --> 00:18:48,260 +الفولات طبعا نقص أحد هذه العناصربيؤدي إلى زيادة في + +243 +00:18:48,260 --> 00:18:53,140 +حجم الخلايا زيادة كبيرة في حجم الخلايا زي ما احنا + +244 +00:18:53,140 --> 00:18:58,920 +عارفين Vitamin B12 والفولات هدول اتنين مهمين في ال + +245 +00:18:58,920 --> 00:19:03,340 +DNA synthesis يعتبروا ك coenzymes في ال DNA + +246 +00:19:03,340 --> 00:19:08,440 +synthesis فإذا كان في نقص فيهم هنلاقي انه في خلل + +247 +00:19:08,440 --> 00:19:14,290 +في عملية انقسام الخلية انقسام النوع بشكل أساسييعني + +248 +00:19:14,290 --> 00:19:19,110 +هتصير أن النوع تكبر لكن لأنه في خلل في العناصر + +249 +00:19:19,110 --> 00:19:23,410 +اللي لازمة لانقسمها لن تنقسم النوع وبالتالي لن + +250 +00:19:23,410 --> 00:19:26,470 +نقسم الـ cytoplasm بعد ذلك الخلية هتطرد النوع + +251 +00:19:26,470 --> 00:19:30,210 +تاعتها ويظل عندي cytoplasm double يعني هذا الـ + +252 +00:19:30,210 --> 00:19:33,510 +cytoplasm اللي عندي كان المفروض انقسم بس لأن النوع + +253 +00:19:33,510 --> 00:19:38,210 +ماقدرتش تنقسم ماقدرش الـ cytoplasm ينقسم طبعا هذا + +254 +00:19:38,210 --> 00:19:43,530 +يؤدي إلى زي ما قلنا megaloplastic maturationالنوع + +255 +00:19:43,530 --> 00:19:49,270 +بتكبر كثير وبالتالي زى ما قولنا بيصير الـHash + +256 +00:19:49,270 --> 00:19:52,050 +انقسم وبالتالي الـCytoplasm مابنقسم كثير عند + +257 +00:19:52,050 --> 00:19:58,570 +الخلية الكبيرة طبعا هذا بينتج عنه Enlarged Fragile + +258 +00:19:58,570 --> 00:20:04,690 +Cell يعني خلايا بتكون هشة وضعيفة معظم هذه الخلايا + +259 +00:20:04,690 --> 00:20:07,910 +أو الكثير منها بيموت في البون مره قبل ما يطلع + +260 +00:20:07,910 --> 00:20:11,280 +الـPeripheral Bloodلأن الخلايا هذه بتكون non + +261 +00:20:11,280 --> 00:20:14,100 +-functional و fragile فبتم التخلص منها في ال bone + +262 +00:20:14,100 --> 00:20:20,460 +marrow أو بتتكسر في ال bone marrow طبعا سواء ال + +263 +00:20:20,460 --> 00:20:23,600 +vitamin B12 أو ال folic acid deficiency التنين + +264 +00:20:23,600 --> 00:20:27,760 +بيعطوني نفس ال blood picture يعني بيعطوني نفس ال + +265 +00:20:27,760 --> 00:20:32,140 +blood film و نفس ال CBCفي الـ Vitamin B12 + +266 +00:20:32,140 --> 00:20:36,520 +deficiency هنا بنلاحظ بعض الأعراض اللي لها علاقة + +267 +00:20:36,520 --> 00:20:43,000 +بالجهاز الأعصاب بتعمل بعض أعراض زي تنميل وخدلان + +268 +00:20:43,000 --> 00:20:47,520 +وأشياء زي هيك طبعا وممكن تعمل nervousness هذا يعني + +269 +00:20:47,520 --> 00:20:51,060 +عادة إذا كانت الـ megaloplastic anemia مصاحبة لهذه + +270 +00:20:51,060 --> 00:20:59,060 +الأعراض بنشك أنه فيه نقص في Vitamin B12 طبعا لأنلو + +271 +00:20:59,060 --> 00:21:03,040 +اجينا هنا نقارن ما بين الـ maturation series في + +272 +00:21:03,040 --> 00:21:07,120 +الـ normal هي الـ normal plastic maturation مقارنة + +273 +00:21:07,120 --> 00:21:11,040 +بالـ megaloplastic maturation زى ما انتوا شايفين + +274 +00:21:11,040 --> 00:21:15,080 +كل الخلايا بتبدأ كبيرة و بتستمر بتظل حجمها كبير + +275 +00:21:15,080 --> 00:21:19,460 +لغاية ما تخرج للـ peripheral blood بينما ال + +276 +00:21:19,460 --> 00:21:22,400 +microcytic طبعا شوفناها في ال microcytic anemia + +277 +00:21:22,400 --> 00:21:25,720 +الخلايا بتبدأ صغيرة و بتطلع عندى microcytic cells + +278 +00:21:28,360 --> 00:21:32,680 +الان نجي لل lab finding في المجال plastic anemia + +279 +00:21:32,680 --> 00:21:37,060 +ايش الأشياء اللى عندى بتبين فى المختبر mild to + +280 +00:21:37,060 --> 00:21:42,840 +severe anemia بإيش بتتميز هذه الانيميا طبعا ال MCV + +281 +00:21:42,840 --> 00:21:48,020 +هيكون عالى ال MCV عالى لأنه الخلايا كبيرة وده حجم + +282 +00:21:48,020 --> 00:21:56,240 +الخلية هيكون كبير ال MCH عالى بينما ال MCHC هيكون + +283 +00:21:56,240 --> 00:22:03,270 +normalطيب ليش الـ MCH عالي و الـ MCHC normal طبعا + +284 +00:22:03,270 --> 00:22:09,110 +الـ MCV لما بيكبر الخلية بتكبر بما فيها من محتوى + +285 +00:22:09,110 --> 00:22:13,770 +هيموجلوبين و احنا اذا فاكرين ان الـ MCH هو عبارة + +286 +00:22:13,770 --> 00:22:18,290 +عن وزن الهيموجلوبين الموجودة داخل الخلية فبديهي + +287 +00:22:18,290 --> 00:22:22,150 +طالما الخلية كبرت هيزيد وزن الهيموجلوبين فيها + +288 +00:22:22,150 --> 00:22:27,610 +وبالتالي الـ MCH هيزيدلكن الـ MCHC زي ما انتوا + +289 +00:22:27,610 --> 00:22:31,510 +عارفين هو بيعبر عن نسبة الـ Hemoglobin الموجود في + +290 +00:22:31,510 --> 00:22:35,610 +الخلية هذا الـ Hemoglobin صح هو وزنته كتيرة لكن + +291 +00:22:35,610 --> 00:22:40,170 +متناسب مع حجم الخلية يعني احنا حقيقة الـ MCHC + +292 +00:22:40,170 --> 00:22:42,990 +بنجيب نسبة مئوية ما بين وزنة الـ Hemoglobin وحجم + +293 +00:22:42,990 --> 00:22:48,730 +الخلية فبالتالي طالما التنين كتروا الـ MCHZ و الـ + +294 +00:22:48,730 --> 00:22:54,160 +MCVZ هتكونوا الـ MCHC Normal عشان هيك صنفناهاإنها + +295 +00:22:54,160 --> 00:23:00,620 +normochromic أنيميا normochromic أنيميا الآن ال + +296 +00:23:00,620 --> 00:23:04,800 +parameters هنلاقي ال RBCs ال hemoglobin ال white + +297 +00:23:04,800 --> 00:23:08,540 +bcs البلايات let's count كلها هذه ممكن نلاقيها لو + +298 +00:23:08,540 --> 00:23:13,000 +لأن الخلايا اللي بتتصنع في هذه الحالة هنلاقيها + +299 +00:23:13,000 --> 00:23:17,700 +fragile cells سهل إنه تتكسر في البومرة أو في أي + +300 +00:23:17,700 --> 00:23:22,140 +مكان طبعا ال radiculocyte count هيكون قليل + +301 +00:23:24,460 --> 00:23:27,780 +Macrocytic Ovalocyte and Teardrops هذه أشياء + +302 +00:23:27,780 --> 00:23:30,480 +بشوفها في الـ Peripheral Blood بشوف Ovalocyte + +303 +00:23:30,480 --> 00:23:35,620 +كبيرة بشوف الـ Teardrop طبعاً Marked in Esocytosis + +304 +00:23:35,620 --> 00:23:39,480 +and Bikilocytosis ممكن أشوف Schistocyte أو + +305 +00:23:39,480 --> 00:23:43,380 +Microcyte ليش؟ لأن الخلايا أساسا زي ما قلنا فرجال + +306 +00:23:43,380 --> 00:23:47,040 +و بتتكسر في البون مرة فبالتالي ممكن أشوف قطعة منها + +307 +00:23:47,040 --> 00:23:52,130 +في ال Peripheral Blood Erythrite Hyperplasiaهلاقي + +308 +00:23:52,130 --> 00:23:57,010 +ان شويه الارثرويد بدت ترتفع عندنا الـ Myeloid + +309 +00:23:57,010 --> 00:24:04,190 +Arterioid Ratio هتنزل الـ Iron Stars هتزيد لأنه + +310 +00:24:04,190 --> 00:24:07,090 +يعني المشكلة ان في نقص في الفوليك أسد او في الـ + +311 +00:24:07,090 --> 00:24:12,630 +Vitamin B12 فكل هذا هيأثر على ان خلايا ماب تتصنع + +312 +00:24:12,630 --> 00:24:16,590 +بشكل كويس في عندنا حديده زيادة الحديد هذا هيبلش + +313 +00:24:16,900 --> 00:24:19,800 +يتخزن يعني إذا ماقلنا دعوة في الحديد الحديد هنا + +314 +00:24:19,800 --> 00:24:22,980 +مافيش فيه مشكلة و الخلل في شيء تاني فبتاع الحديد + +315 +00:24:22,980 --> 00:24:26,220 +هيبدأ يزيد عن حاجة الجسم و يتجمع في ال bone marrow + +316 +00:24:26,220 --> 00:24:31,260 +و في ال iron stars عندى هنا أكتر من blood film + +317 +00:24:31,260 --> 00:24:35,520 +بيبين الحالات هذه بداية أول حاجة بدنا نلاحظ الحجم + +318 +00:24:35,520 --> 00:24:39,520 +تاع الخلايا الشكل تاع الخلايا في عندنا ovalocyte + +319 +00:24:39,520 --> 00:24:43,900 +زى ما انتوا شايفين ملحوظة اذا macrocytic ovalocyte + +320 +00:24:43,900 --> 00:24:50,820 +هيه هناهنا عندنا الوجود نيوكلياتد RBCs ممكن أشوف + +321 +00:24:50,820 --> 00:24:54,940 +نيوكلياتد RBCs ممكن أشوف tear drop ممكن أشوف + +322 +00:24:54,940 --> 00:24:58,140 +schistocyte ممكن أشوف هوالجولي بادي اللي هو عبارة + +323 +00:24:58,140 --> 00:25:03,620 +عن بقايا DNA الهوالجولي بادي Basophilic stapling + +324 +00:25:03,620 --> 00:25:07,460 +ممكن أشوف giant platelets ممكن أشوف evenhymer + +325 +00:25:07,460 --> 00:25:13,500 +bodies في عند هنا يعني حاجة بيعتبروها مميزة لحالات + +326 +00:25:13,500 --> 00:25:17,270 +ال megaloplastic anemiaاللي هي وجود hyper + +327 +00:25:17,270 --> 00:25:20,710 +-segmented neutrophil يعني هتلاقي الـ neutrophil + +328 +00:25:20,710 --> 00:25:26,290 +فيها hyper-segmentation البول مرة عامة بيشتغل بأقل + +329 +00:25:26,290 --> 00:25:30,390 +من راحته بأقل من مهله فبالتالي هتلاقي الخلايا + +330 +00:25:30,390 --> 00:25:37,010 +هيصيرلها hyper-segmentation نيجي + +331 +00:25:37,010 --> 00:25:41,260 +لـ vitamin B12 deficiencyالان vitamin B12 + +332 +00:25:41,260 --> 00:25:44,000 +deficiency زى ما احنا عارفين هو مهم جدا فى تصنيع + +333 +00:25:44,000 --> 00:25:47,200 +الـmyelinشى بتاع الخلايا العصبية فده صار فيه + +334 +00:25:47,200 --> 00:25:50,900 +deficiency من ضمن الأشياء إضافة للأنيميا بيصير + +335 +00:25:50,900 --> 00:25:54,940 +عنها أعراض عصبية زى ما حكينا طيب من .. من يعني من + +336 +00:25:54,940 --> 00:25:58,540 +إيش بيصير فيه deficiency؟ إما إنه خلل في كمية ال + +337 +00:25:58,540 --> 00:26:02,680 +vitamin B12 اللى بيخدها الإنسان أو خلل في امتصاصه + +338 +00:26:02,680 --> 00:26:07,630 +وفي الاستفادة منه فى داخل الجسمأول حاجة يعني أول + +339 +00:26:07,630 --> 00:26:12,630 +الأسباب الـ nutritional deficiency أو أن الطعام + +340 +00:26:12,630 --> 00:26:16,070 +اللي بيتاخد بسرعهاش البروتيولايزيزي كويس في ال .. + +341 +00:26:16,070 --> 00:26:19,790 +في ال .. في الـ stomach وبالتالي مابيطلعش vitamin + +342 +00:26:19,790 --> 00:26:24,070 +B12 بالطريقة اللي ممكن الجسم يستفيد منها loss or + +343 +00:26:24,070 --> 00:26:27,170 +atrophy of gastric mucosa يعني لو صار مشكلة في + +344 +00:26:27,170 --> 00:26:31,620 +المعدة في الـ gastric mucosaممكن يصير Deficiency + +345 +00:26:31,620 --> 00:26:34,420 +في الـ Intrinsic Factor اللي هو برتبط مع الـ + +346 +00:26:34,420 --> 00:26:37,880 +Vitamin B12 و بيصير له امتصاص هناك فإذا كان فيه + +347 +00:26:37,880 --> 00:26:42,360 +نقص في الـ Intrinsic Factor هذا مش راح يصير امتصاص + +348 +00:26:42,360 --> 00:26:46,540 +لـ Vitamin B12 abnormal events in small bowel + +349 +00:26:46,540 --> 00:26:49,480 +اليومين يعني فيه مشكلة في الأمعاء الدقيقة في الـ + +350 +00:26:49,480 --> 00:26:52,620 +small bowel ممكن تكون inadequate pancreatic + +351 +00:26:52,620 --> 00:26:56,080 +protease كمية البروتياز الموجود في البنكرياز اللي + +352 +00:26:56,080 --> 00:26:59,800 +بيفرزه البنكرياز غير كافيةcompeting agent like + +353 +00:26:59,800 --> 00:27:03,780 +فيشتاب وفوق worms ممكن هذا الأنواع من الدي دا + +354 +00:27:03,780 --> 00:27:08,300 +تنافس على هذا ال vitamin وعلى ال food بالنسبة + +355 +00:27:08,300 --> 00:27:12,180 +للفولية الدفيشنسي أو ال folic acid دفيشنسي بالنسبة + +356 +00:27:12,180 --> 00:27:16,720 +للفولية الدفيشنسي طبعا ممكن يكون بسبب deficient + +357 +00:27:16,720 --> 00:27:21,030 +intactمع الحاجة الذائدة إلهم زي في حالات ال + +358 +00:27:21,030 --> 00:27:24,970 +pregnancy في حالات الأطفال في حالات زيادة ال + +359 +00:27:24,970 --> 00:27:28,750 +proliferation بتاع الخلايا في حالات الsterosis + +360 +00:27:28,750 --> 00:27:34,530 +برضه يعني ممكن يكون صيرله malabsorption ممكن يكون + +361 +00:27:34,530 --> 00:27:38,130 +بسبب congenital and drug induced يعني أسباب يعني + +362 +00:27:38,130 --> 00:27:43,090 +عيوب خلقية أو بسبب بعض الأدوية ممكن يكون في خلل في + +363 +00:27:43,090 --> 00:27:48,430 +ال metabolism بتاع الفلاتزي مثلا نقص ثيابين أو بعض + +364 +00:27:48,430 --> 00:27:51,570 +الانزايم المسؤولة عن تمثيل الفلات + +365 +00:29:01,970 --> 00:29:07,010 +الـ chilling test يستخدم لتشخيص البرنشيوسانيميا + +366 +00:29:07,010 --> 00:29:10,890 +ونشوف يعني عشان نشوف أشي المشكلة اللي قدت لحدوث + +367 +00:29:10,890 --> 00:29:14,290 +نقص vitamin B12 أنا بروح بعطي المريض جرعة من + +368 +00:29:14,290 --> 00:29:18,770 +vitamin B12 وبتابع الجرعة هذه الآن إذا ظهرت في ال + +369 +00:29:18,770 --> 00:29:23,930 +urine بعد الكلام إنه المريض ماعندهوش مشكلة وإنما + +370 +00:29:23,930 --> 00:29:28,390 +مشكلته كانت في نقص malnutrition يعني مشكلته + +371 +00:29:28,390 --> 00:29:31,540 +nutritional deficiencyيعني ما عنده مشكلة في الـ + +372 +00:29:31,540 --> 00:29:36,340 +absorption لكن لو ما ظهرت بالـ urine بروح بعطي + +373 +00:29:36,340 --> 00:29:40,760 +المرحلة التانية بعطي مع الـ vitamin B12 intrinsic + +374 +00:29:40,760 --> 00:29:45,740 +factor هلاقيت إذا كان بعد ما أعطيت الـ intrinsic + +375 +00:29:45,740 --> 00:29:49,340 +factor ظهر الـ vitamin B12 اللي أنا أعطيته في الـ + +376 +00:29:49,340 --> 00:29:52,480 +urine معنى الكلام إنه المشكلة في الـ intrinsic + +377 +00:29:52,480 --> 00:29:57,780 +factor ولمّا أنا دخلته انحلت المشكلة لكن لو ما ظهر + +378 +00:29:57,780 --> 00:30:00,440 +بالـ urineبنخش على المرحلة اللى بعدها اللى هى + +379 +00:30:00,440 --> 00:30:03,720 +المرحلة التالتة بيكون فى احتمال بشوف إذا كان فى + +380 +00:30:03,720 --> 00:30:07,420 +مشكلة فى ال intestine أو فى ال pancreas تمام هذا + +381 +00:30:07,420 --> 00:30:11,640 +يعني فترة بسيطة عن shelling test نجى الى non + +382 +00:30:11,640 --> 00:30:16,580 +megaloplastic anemia هنا بتكون المشكلة أن الخلايا + +383 +00:30:16,580 --> 00:30:21,380 +كبيرة بس مش بسبب نقص ال vitamin B12 أو الفولات + +384 +00:30:21,380 --> 00:30:26,950 +عغالبايعني أهم الأسباب شيوعا انه في اندي + +385 +00:30:26,950 --> 00:30:30,150 +accelerated erythropiasis يعني البول مارو بيشتغل + +386 +00:30:30,150 --> 00:30:33,610 +تحت stress فبالتالي بيطلع عند ال reticulocyte هيها + +387 +00:30:33,610 --> 00:30:38,290 +مبينة هنا في ال V في الصورة خلايا أكبر من الطبيعي + +388 +00:30:38,290 --> 00:30:41,390 +بشوية ولونها ماخد اللون ما بين ال pink لل blue + +389 +00:30:41,390 --> 00:30:48,550 +طبعا هذه بتؤدي إلى ارتفاع ال MCVفي الحالات الأخرى + +390 +00:30:48,550 --> 00:30:51,270 +أيضًا اللي هي liver disease and alcoholism هنا + +391 +00:30:51,270 --> 00:30:54,250 +بيصير عندهم درجة من الأنيميا بلاقي عندهم round + +392 +00:30:54,250 --> 00:30:58,850 +macrocytosis بلاقي عندهم boiculocytosis يعني ممكن + +393 +00:30:58,850 --> 00:31:02,430 +أشوف target cell أكانسوسيت ممكن أشوف أكينوسيت + +394 +00:31:02,430 --> 00:31:07,310 +طبعًا لأنه بيبقى في عندهم نقص في ال lipid أو مشكلة + +395 +00:31:07,310 --> 00:31:10,190 +في ال lipid metabolism طبعًا ال lipid مهمة جدًا في + +396 +00:31:10,190 --> 00:31:13,630 +still membrane فبالتالي إذا كان فيها deficiencyهذا + +397 +00:31:13,630 --> 00:31:17,250 +بيقدّي إلى إن الـ cell membrane ما بتكون بشكل + +398 +00:31:17,250 --> 00:31:20,590 +طبيعي فبتظهر عندي الـ acanthocyte و الـ echinocyte + +399 +00:31:20,590 --> 00:31:26,130 +و الأشكال الأخرى من الخلايا نيجي + +400 +00:31:26,130 --> 00:31:29,270 +للـ differential diagnosis كيف نميز أنواع الأنيميا + +401 +00:31:29,270 --> 00:31:32,290 +هل هي megaloplastic و لا non-megaloplastic بنعمل + +402 +00:31:32,290 --> 00:31:36,990 +vitamin B12 و الـ folate level ممكن بعض الحاجات + +403 +00:31:36,990 --> 00:31:40,690 +تكون مميزة لـ megaloplastic anemia زي وجود الـ + +404 +00:31:40,690 --> 00:31:44,570 +hyper-segmented neutrophilوبرضه بعض الـ morphology + +405 +00:31:44,570 --> 00:31:49,270 +الأخرى اللي ممكن تدلل يعني لو عملنا لو لاحظنا في + +406 +00:31:49,270 --> 00:31:51,710 +ال blood film اللي هو فيه macrocytosis اللي هي non + +407 +00:31:51,710 --> 00:31:55,410 +-megaloplastic مثلا هلاحظ فيه اللي هي الـ + +408 +00:31:55,410 --> 00:31:57,910 +polychromagia اللي هي ال radiculocyte بعدد كبير + +409 +00:31:57,910 --> 00:32:00,530 +بينما هنا مابتكونش موجودة في ال megaloplastic + +410 +00:32:00,530 --> 00:32:05,170 +أنيما ع سبيل المثال برضه لو كانت حالة liver + +411 +00:32:05,170 --> 00:32:08,530 +disease هنلاقي تغير في أشكال الخلايا اللي هي راجع + +412 +00:32:08,530 --> 00:32:10,870 +على خلال في cell membrane زي الacanthocyte أو ال + +413 +00:32:11,980 --> 00:32:12,400 +وهكذا + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo_raw.json b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..82aa6c93f0ac1e24f7d655c7a7132b3f7e612786 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/Cu7s3QFEnyo_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 3131, "start": 1.69, "end": 31.31, "text": "الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم الدم التشخيصي diagnostic hematology زي ما اتكلمنا مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن أمراض الدم تقريبا", "tokens": [6027, 43761, 9154, 25124, 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{"start": 152.65, "end": 153.17, "word": " Molecule", "probability": 0.93212890625}, {"start": 153.17, "end": 153.63, "word": " أربعة", "probability": 0.7037760416666666}, {"start": 153.63, "end": 155.23, "word": " إجلوبين", "probability": 0.611083984375}, {"start": 155.23, "end": 155.61, "word": " Chain", "probability": 0.734375}, {"start": 155.61, "end": 156.15, "word": " وأربعة", "probability": 0.6876627604166666}, {"start": 156.15, "end": 156.49, "word": " هيم", "probability": 0.5230712890625}, {"start": 156.49, "end": 157.03, "word": " إجروب", "probability": 0.75543212890625}], "temperature": 1.0}, {"id": 7, "seek": 17607, "start": 157.49, "end": 176.07, "text": "هي Hemoglobin chain مثلا هي Hemoglobin molecule العادي بيكون فيه هي Hem Hem Hem أربع Hem وفي عنده ال globin ال globin بتكون من two alpha و two beta chain في ال adult ال normal هلاقي 97% من ال hemoglobin Hemoglobin A", "tokens": [3224, 1829, 18568, 45841, 13496, 5021, 50113, 15040, 39896, 18568, 45841, 13496, 15582, 18863, 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634.12, "end": 634.48, "word": " fetalis", "probability": 0.5543212890625}, {"start": 634.48, "end": 634.68, "word": " بس", "probability": 0.92529296875}, {"start": 634.68, "end": 634.86, "word": " انا", "probability": 0.788330078125}, {"start": 634.86, "end": 635.08, "word": " هنا", "probability": 0.88916015625}, {"start": 635.08, "end": 635.34, "word": " بدي", "probability": 0.568603515625}, {"start": 635.34, "end": 635.84, "word": " اقولكم", "probability": 0.8649088541666666}, {"start": 635.84, "end": 636.34, "word": " كمان", "probability": 0.8986002604166666}, {"start": 636.34, "end": 636.96, "word": " في", "probability": 0.80810546875}, {"start": 636.96, "end": 637.1, "word": " ال", "probability": 0.92578125}, {"start": 637.1, "end": 637.32, "word": " alpha", "probability": 0.373291015625}, {"start": 637.32, "end": 637.86, "word": "-thalassemia", "probability": 0.7564453125}, {"start": 637.86, "end": 638.58, "word": " intermediate", "probability": 0.97705078125}, {"start": 638.58, "end": 639.18, "word": " هنلاقي", "probability": 0.864013671875}, {"start": 639.18, "end": 639.42, "word": " ال", "probability": 0.9404296875}, {"start": 639.42, "end": 639.64, "word": " alpha", "probability": 0.71484375}, {"start": 639.64, "end": 640.16, "word": "-thalassemia", "probability": 0.97216796875}, {"start": 640.16, "end": 640.64, "word": " minor", "probability": 0.98681640625}, {"start": 640.64, "end": 641.42, "word": " هنلاقي", "probability": 0.962646484375}, {"start": 641.42, "end": 641.56, "word": " ال", "probability": 0.94580078125}, {"start": 641.56, "end": 642.32, "word": " electrophoresis", "probability": 0.7706298828125}, {"start": 642.32, "end": 642.7, "word": " لإلها", "probability": 0.6610107421875}, {"start": 642.7, "end": 642.96, "word": " زي", "probability": 0.981201171875}, {"start": 642.96, "end": 643.06, "word": " و", "probability": 0.53466796875}, {"start": 643.06, "end": 643.28, "word": " زي", "probability": 0.7861328125}, {"start": 643.28, "end": 643.42, "word": " ال", "probability": 0.6220703125}, {"start": 643.42, "end": 643.72, "word": " normal", "probability": 0.6484375}, {"start": 643.72, "end": 644.72, "word": " electrophoresis", "probability": 0.92236328125}], "temperature": 1.0}, {"id": 23, "seek": 67632, "start": 647.96, "end": 676.32, "text": "بالكلام اللي حكيناه بس أنا بدي أورجيكم نسب الـ Hemoglobin في كل حالة يعني عند الـ Beta-thalassemia في عند الـ homozygous هنلاقي Hemoglobin F من 40 إلى 90% في الـ Beta-thalassemia minor هنلاقي Hemoglobin A2 هو الارتفاع بس برضه مش هيرتفع كتير من 3.5 إلى 7% Hemoglobin F هتلاقيه normal في 50% من الحالات", "tokens": [3555, 6027, 28820, 10943, 13672, 1829, 11331, 4117, 1829, 8315, 3224, 4724, 3794, 41850, 4724, 16254, 5551, 13063, 7435, 1829, 24793, 8717, 35457, 2423, 39184, 18568, 45841, 13496, 8978, 28242, 11331, 6027, 3660, 37495, 22653, 43242, 2423, 39184, 33286, 12, 392, 304, 640, 14058, 8978, 43242, 2423, 39184, 3655, 78, 1229, 70, 563, 8032, 1863, 15040, 38436, 18568, 45841, 13496, 479, 9154, 3356, 30731, 4289, 4, 8978, 2423, 39184, 33286, 12, 392, 304, 640, 14058, 6696, 8032, 1863, 15040, 38436, 18568, 45841, 13496, 316, 17, 31439, 2423, 9640, 2655, 5172, 45761, 4724, 3794, 4724, 43042, 3224, 37893, 8032, 13546, 2655, 5172, 3615, 9122, 2655, 13546, 9154, 805, 13, 20, 30731, 1614, 4, 18568, 45841, 13496, 479, 8032, 2655, 15040, 38436, 3224, 2710, 8978, 2625, 4, 9154, 21542, 6027, 9307], "avg_logprob": -0.1243990312402065, "compression_ratio": 1.7341269841269842, "no_speech_prob": 2.86102294921875e-05, "words": [{"start": 647.96, "end": 648.44, "word": "بالكلام", "probability": 0.719970703125}, {"start": 648.44, "end": 648.58, "word": " اللي", "probability": 0.851806640625}, {"start": 648.58, "end": 649.42, "word": " حكيناه", "probability": 0.9525390625}, {"start": 649.42, "end": 649.82, "word": " بس", "probability": 0.9443359375}, {"start": 649.82, "end": 650.1, "word": " أنا", "probability": 0.84423828125}, {"start": 650.1, "end": 650.54, "word": " بدي", "probability": 0.838623046875}, {"start": 650.54, "end": 651.3, "word": " أورجيكم", "probability": 0.841796875}, {"start": 651.3, "end": 651.62, "word": " نسب", "probability": 0.986328125}, {"start": 651.62, "end": 651.84, "word": " الـ", "probability": 0.7322998046875}, {"start": 651.84, "end": 652.4, "word": " Hemoglobin", "probability": 0.7926432291666666}, {"start": 652.4, "end": 652.72, "word": " في", "probability": 0.748046875}, {"start": 652.72, "end": 652.96, "word": " كل", "probability": 0.990234375}, {"start": 652.96, "end": 653.48, "word": " حالة", "probability": 0.9978841145833334}, {"start": 653.48, "end": 654.02, "word": " يعني", "probability": 0.841796875}, {"start": 654.02, "end": 654.18, "word": " عند", "probability": 0.81201171875}, {"start": 654.18, "end": 654.4, "word": " الـ", "probability": 0.668212890625}, {"start": 654.4, "end": 654.5, "word": " Beta", "probability": 0.6875}, {"start": 654.5, "end": 655.18, "word": "-thalassemia", "probability": 0.74697265625}, {"start": 655.18, "end": 656.34, "word": " في", "probability": 0.9140625}, {"start": 656.34, "end": 656.58, "word": " عند", "probability": 0.97314453125}, {"start": 656.58, "end": 656.88, "word": " الـ", "probability": 0.89794921875}, {"start": 656.88, "end": 657.58, "word": " homozygous", "probability": 0.823876953125}, {"start": 657.58, "end": 657.94, "word": " هنلاقي", "probability": 0.9451904296875}, {"start": 657.94, "end": 658.42, "word": " Hemoglobin", "probability": 0.91162109375}, {"start": 658.42, "end": 658.62, "word": " F", "probability": 0.89892578125}, {"start": 658.62, "end": 658.8, "word": " من", "probability": 0.9677734375}, {"start": 658.8, "end": 659.2, "word": " 40", "probability": 0.884765625}, {"start": 659.2, "end": 659.4, "word": " إلى", "probability": 0.81396484375}, {"start": 659.4, "end": 659.86, "word": " 90", "probability": 0.99267578125}, {"start": 659.86, "end": 660.34, "word": "%", "probability": 0.77197265625}, {"start": 660.34, "end": 661.72, "word": " في", "probability": 0.89404296875}, {"start": 661.72, "end": 661.86, "word": " الـ", "probability": 0.92919921875}, {"start": 661.86, "end": 662.02, "word": " Beta", "probability": 0.89892578125}, {"start": 662.02, "end": 662.56, "word": "-thalassemia", "probability": 0.9509765625}, {"start": 662.56, "end": 663.1, "word": " minor", "probability": 0.7685546875}, {"start": 663.1, "end": 664.1, "word": " هنلاقي", "probability": 0.98046875}, {"start": 664.1, "end": 664.66, "word": " Hemoglobin", "probability": 0.97119140625}, {"start": 664.66, "end": 665.2, "word": " A2", "probability": 0.9892578125}, {"start": 665.2, "end": 666.22, "word": " هو", "probability": 0.96875}, {"start": 666.22, "end": 666.92, "word": " الارتفاع", "probability": 0.88388671875}, {"start": 666.92, "end": 667.42, "word": " بس", "probability": 0.970703125}, {"start": 667.42, "end": 667.62, "word": " برضه", "probability": 0.9283854166666666}, {"start": 667.62, "end": 667.76, "word": " مش", "probability": 0.98388671875}, {"start": 667.76, "end": 668.14, "word": " هيرتفع", "probability": 0.9068359375}, {"start": 668.14, "end": 668.56, "word": " كتير", "probability": 0.9749348958333334}, {"start": 668.56, "end": 669.2, "word": " من", "probability": 0.947265625}, {"start": 669.2, "end": 669.46, "word": " 3", "probability": 0.91552734375}, {"start": 669.46, "end": 669.84, "word": ".5", "probability": 0.951416015625}, {"start": 669.84, "end": 670.04, "word": " إلى", "probability": 0.96435546875}, {"start": 670.04, "end": 670.56, "word": " 7", "probability": 0.99462890625}, {"start": 670.56, "end": 671.56, "word": "%", "probability": 0.9443359375}, {"start": 671.56, "end": 672.4, "word": " Hemoglobin", "probability": 0.95751953125}, {"start": 672.4, "end": 672.76, "word": " F", "probability": 0.98583984375}, {"start": 672.76, "end": 674.24, "word": " هتلاقيه", "probability": 0.966015625}, {"start": 674.24, "end": 674.52, "word": " normal", "probability": 0.493408203125}, {"start": 674.52, "end": 674.74, "word": " في", "probability": 0.962890625}, {"start": 674.74, "end": 675.06, "word": " 50", "probability": 0.96923828125}, {"start": 675.06, "end": 675.44, "word": "%", "probability": 0.9853515625}, {"start": 675.44, "end": 675.68, "word": " من", "probability": 0.9951171875}, {"start": 675.68, "end": 676.32, "word": " الحالات", "probability": 0.98291015625}], "temperature": 1.0}, {"id": 24, "seek": 68714, "start": 679.28, "end": 687.14, "text": "بالنسبة للـ Alpha-thalassemia الـ homozygous الـ major هنلاقي hemoglobin parts بشكل 80% في الـ cord blood", "tokens": [3555, 6027, 1863, 35457, 3660, 24976, 39184, 20588, 12, 392, 304, 640, 14058, 2423, 39184, 3655, 78, 1229, 70, 563, 2423, 39184, 2563, 8032, 1863, 15040, 38436, 8636, 45841, 13496, 3166, 4724, 8592, 28820, 4688, 4, 8978, 2423, 39184, 12250, 3390], "avg_logprob": -0.2591145762375423, "compression_ratio": 1.088, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 679.28, "end": 679.78, "word": "بالنسبة", "probability": 0.98466796875}, {"start": 679.78, "end": 679.96, "word": " للـ", "probability": 0.8701171875}, {"start": 679.96, "end": 680.14, "word": " Alpha", "probability": 0.57861328125}, {"start": 680.14, "end": 680.86, "word": "-thalassemia", "probability": 0.75078125}, {"start": 680.86, "end": 681.62, "word": " الـ", "probability": 0.881591796875}, {"start": 681.62, "end": 682.34, "word": " homozygous", "probability": 0.854638671875}, {"start": 682.34, "end": 682.52, "word": " الـ", "probability": 0.629150390625}, {"start": 682.52, "end": 682.76, "word": " major", "probability": 0.92333984375}, {"start": 682.76, "end": 683.32, "word": " هنلاقي", "probability": 0.83587646484375}, {"start": 683.32, "end": 684.3, "word": " hemoglobin", "probability": 0.7564290364583334}, {"start": 684.3, "end": 684.74, "word": " parts", "probability": 0.8740234375}, {"start": 684.74, "end": 685.42, "word": " بشكل", "probability": 0.9474283854166666}, {"start": 685.42, "end": 685.82, "word": " 80", "probability": 0.94970703125}, {"start": 685.82, "end": 686.3, "word": "%", "probability": 0.96435546875}, {"start": 686.3, "end": 686.58, "word": " في", "probability": 0.453125}, {"start": 686.58, "end": 686.66, "word": " الـ", "probability": 0.288818359375}, {"start": 686.66, "end": 686.86, "word": " cord", "probability": 0.71533203125}, {"start": 686.86, "end": 687.14, "word": " blood", "probability": 0.95361328125}], "temperature": 1.0}, {"id": 25, "seek": 71131, "start": 688.49, "end": 711.31, "text": "طبعا بعد هيك تيجي عند الـ Intermediate هتلاقي Hemoglobin H نسبته من 4 إلى 30% unstable or non-functional بسيروتكسير الـ Alpha-thalassemia heterozygous هتلاقي فيها Hemoglobin parts من 1 إلى 10% في ال cord blood مش في الأدل طبعا Hemoglobin H نادر لما نشوفه في ال cord blood", "tokens": [9566, 3555, 3615, 995, 39182, 39896, 4117, 6055, 1829, 7435, 1829, 43242, 2423, 39184, 5751, 3130, 473, 8032, 2655, 15040, 38436, 18568, 45841, 13496, 389, 8717, 35457, 47395, 9154, 1017, 30731, 2217, 4, 23742, 420, 2107, 12, 22845, 304, 4724, 3794, 13546, 35473, 4117, 3794, 13546, 2423, 39184, 20588, 12, 392, 304, 640, 14058, 3639, 2032, 1229, 70, 563, 8032, 2655, 15040, 38436, 8978, 11296, 18568, 45841, 13496, 3166, 9154, 502, 30731, 1266, 4, 8978, 2423, 12250, 3390, 37893, 8978, 16247, 3215, 1211, 23032, 3555, 3615, 995, 18568, 45841, 13496, 389, 8717, 18513, 2288, 5296, 15042, 8717, 8592, 38688, 3224, 8978, 2423, 12250, 3390], "avg_logprob": -0.2123511961528233, "compression_ratio": 1.5081967213114753, "no_speech_prob": 7.450580596923828e-06, "words": [{"start": 688.49, "end": 689.37, "word": "طبعا", "probability": 0.93212890625}, {"start": 689.37, "end": 690.25, "word": " بعد", "probability": 0.7802734375}, {"start": 690.25, "end": 690.55, "word": " هيك", "probability": 0.66357421875}, {"start": 690.55, "end": 690.87, "word": " تيجي", "probability": 0.9044189453125}, {"start": 690.87, "end": 691.05, "word": " عند", "probability": 0.97900390625}, {"start": 691.05, "end": 691.23, "word": " الـ", "probability": 0.735595703125}, {"start": 691.23, "end": 691.91, "word": " Intermediate", "probability": 0.6808268229166666}, {"start": 691.91, "end": 692.53, "word": " هتلاقي", "probability": 0.9451904296875}, {"start": 692.53, "end": 693.35, "word": " Hemoglobin", "probability": 0.93017578125}, {"start": 693.35, "end": 693.63, "word": " H", "probability": 0.43408203125}, {"start": 693.63, "end": 694.11, "word": " نسبته", "probability": 0.9794921875}, {"start": 694.11, "end": 694.25, "word": " من", "probability": 0.9833984375}, {"start": 694.25, "end": 694.57, "word": " 4", "probability": 0.91015625}, {"start": 694.57, "end": 694.83, "word": " إلى", "probability": 0.77685546875}, {"start": 694.83, "end": 695.33, "word": " 30", "probability": 0.98681640625}, {"start": 695.33, "end": 695.85, "word": "%", "probability": 0.8818359375}, {"start": 695.85, "end": 696.63, "word": " unstable", "probability": 0.372314453125}, {"start": 696.63, "end": 696.95, "word": " or", "probability": 0.59814453125}, {"start": 696.95, "end": 697.19, "word": " non", "probability": 0.974609375}, {"start": 697.19, "end": 697.73, "word": "-functional", "probability": 0.8040364583333334}, {"start": 697.73, "end": 698.51, "word": " بسيروتكسير", "probability": 0.7363630022321429}, {"start": 698.51, "end": 699.07, "word": " الـ", "probability": 0.6026611328125}, {"start": 699.07, "end": 699.19, "word": " Alpha", "probability": 0.375244140625}, {"start": 699.19, "end": 699.73, "word": "-thalassemia", "probability": 0.7837890625}, {"start": 699.73, "end": 700.59, "word": " heterozygous", "probability": 0.8306640625}, {"start": 700.59, "end": 701.33, "word": " هتلاقي", "probability": 0.9677734375}, {"start": 701.33, "end": 701.77, "word": " فيها", "probability": 0.99365234375}, {"start": 701.77, "end": 702.41, "word": " Hemoglobin", "probability": 0.9508463541666666}, {"start": 702.41, "end": 702.79, "word": " parts", "probability": 0.6015625}, {"start": 702.79, "end": 703.03, "word": " من", "probability": 0.99169921875}, {"start": 703.03, "end": 703.35, "word": " 1", "probability": 0.9755859375}, {"start": 703.35, "end": 703.73, "word": " إلى", "probability": 0.9697265625}, {"start": 703.73, "end": 704.39, "word": " 10", "probability": 0.9833984375}, {"start": 704.39, "end": 704.93, "word": "%", "probability": 0.9326171875}, {"start": 704.93, "end": 705.49, "word": " في", "probability": 0.95263671875}, {"start": 705.49, "end": 705.59, "word": " ال", "probability": 0.4609375}, {"start": 705.59, "end": 705.85, "word": " cord", "probability": 0.405029296875}, {"start": 705.85, "end": 706.29, "word": " blood", "probability": 0.9462890625}, {"start": 706.29, "end": 706.87, "word": " مش", "probability": 0.87939453125}, {"start": 706.87, "end": 706.99, "word": " في", "probability": 0.93701171875}, {"start": 706.99, "end": 707.29, "word": " الأدل", "probability": 0.5673828125}, {"start": 707.29, "end": 707.73, "word": " طبعا", "probability": 0.9525146484375}, {"start": 707.73, "end": 708.27, "word": " Hemoglobin", "probability": 0.95263671875}, {"start": 708.27, "end": 708.61, "word": " H", "probability": 0.9638671875}, {"start": 708.61, "end": 709.19, "word": " نادر", "probability": 0.98193359375}, {"start": 709.19, "end": 709.71, "word": " لما", "probability": 0.9013671875}, {"start": 709.71, "end": 710.55, "word": " نشوفه", "probability": 0.9691162109375}, {"start": 710.55, "end": 710.69, "word": " في", "probability": 0.98291015625}, {"start": 710.69, "end": 710.81, "word": " ال", "probability": 0.439453125}, {"start": 710.81, "end": 711.01, "word": " cord", "probability": 0.9189453125}, {"start": 711.01, "end": 711.31, "word": " blood", "probability": 0.94482421875}], "temperature": 1.0}, {"id": 26, "seek": 74057, "start": 711.63, "end": 740.57, "text": "والـ Hemoglobin A تقريباً هيكون فيه slight decrease و البقية النامية هيكون ال profile بتاعها زي و زي ال normal Hemoglobin Electro في كل شيء هنا يعني عمللي differential diagnosis بين 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finding في المجال plastic anemia ايش الأشياء اللى عندى بتبين فى المختبر mild to severe anemia بإيش بتتميز هذه الانيميا طبعا ال MCV هيكون عالى ال MCV عالى لأنه الخلايا كبيرة وده حجم الخلية هيكون كبير ال MCH عالى بينما ال MCHC هيكون normal", "tokens": [6027, 7649, 8717, 7435, 1829, 24976, 2715, 5006, 8978, 9673, 7435, 6027, 5900, 364, 14058, 1975, 1829, 8592, 16247, 8592, 1829, 16606, 13672, 7578, 43242, 7578, 39894, 3555, 9957, 6156, 7578, 9673, 46456, 26890, 15154, 281, 8922, 364, 14058, 4724, 28814, 1829, 8592, 39894, 39237, 1829, 11622, 29538, 2423, 7649, 32640, 25528, 23032, 3555, 3615, 995, 2423, 8797, 53, 39896, 30544, 6225, 6027, 7578, 2423, 8797, 53, 6225, 6027, 7578, 5296, 33456, 3224, 33962, 15040, 25528, 9122, 3555, 48923, 4032, 3215, 3224, 11331, 7435, 2304, 33962, 1211, 10632, 39896, 30544, 9122, 3555, 13546, 2423, 376, 5462, 6225, 6027, 7578, 49374, 15042, 2423, 376, 5462, 34, 39896, 30544, 2710], "avg_logprob": -0.19366399027885647, "compression_ratio": 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normal", "probability": 0.7333984375}], "temperature": 1.0}, {"id": 48, "seek": 134415, "start": 1317.63, "end": 1344.15, "text": "طيب ليش الـ MCH عالي و الـ MCHC normal طبعا الـ MCV لما بيكبر الخلية بتكبر بما فيها من محتوى هيموجلوبين و احنا اذا فاكرين ان الـ MCH هو عبارة عن وزن الهيموجلوبين الموجودة داخل الخلية فبديهي طالما الخلية كبرت هيزيد وزن الهيموجلوبين فيها وبالتالي الـ MCH هيزيد", "tokens": [9566, 1829, 3555, 32239, 8592, 2423, 39184, 376, 5462, 6225, 6027, 1829, 4032, 2423, 39184, 376, 5462, 34, 2710, 23032, 3555, 3615, 995, 2423, 39184, 8797, 53, 5296, 15042, 4724, 1829, 4117, 26890, 33962, 1211, 10632, 39894, 4117, 26890, 4724, 15042, 8978, 11296, 9154, 3714, 33753, 2407, 7578, 8032, 32640, 29245, 1211, 37746, 9957, 4032, 1975, 5016, 8315, 1975, 15730, 6156, 995, 37983, 9957, 16472, 2423, 39184, 376, 5462, 31439, 6225, 3555, 9640, 3660, 18871, 4032, 11622, 1863, 2423, 3224, 32640, 29245, 1211, 37746, 9957, 9673, 29245, 23328, 3660, 11778, 47283, 1211, 33962, 1211, 10632, 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00:00:35,580 +لكل نوع من هذه الأنواع سواء كانت acute أو chronic + +8 +00:00:35,580 --> 00:00:40,360 +بداية نحكي مقدمة بسيطة عن الـ acute leukemia إيش + +9 +00:00:40,360 --> 00:00:44,350 +هي الـ acute leukemia what is acute leukemia الـ + +10 +00:00:44,350 --> 00:00:48,550 +Acute Leukemia عبارة عن group of malignant + +11 +00:00:48,550 --> 00:00:53,950 +disorders مجموعة من الـ malignant disorders والتي + +12 +00:00:53,950 --> 00:00:59,390 +تتميز بأنه بيصير فيها uncontrolled clonal + +13 +00:00:59,390 --> 00:01:06,710 +proliferation لنوع من الخلايا and accumulation of + +14 +00:01:06,710 --> 00:01:10,150 +poorly differentiated blast cells in the bone + +15 +00:01:10,150 --> 00:01:13,750 +marrow and other tissues blast cells بيصير لها + +16 +00:01:13,750 --> 00:01:20,030 +uncontrolled proliferation يعني بيصير تتكاثر + +17 +00:01:20,030 --> 00:01:26,810 +بطريقة غير مسبوقة مما يؤدي لتراكم هذه الخلايا في + +18 +00:01:26,810 --> 00:01:34,050 +البون مارو والأنسجة الأخرى طبعا، الآن هذه الخلايا + +19 +00:01:34,050 --> 00:01:38,990 +لما يزيد عددها في البون مارو إيش بينتج عنها؟ تعمل + +20 +00:01:38,990 --> 00:01:43,950 +Replacement of bone marrow normal elements يعني + +21 +00:01:43,950 --> 00:01:47,230 +الخلايا الطبيعية في البون مارو المسؤولة عن الـ + +22 +00:01:47,230 --> 00:01:51,350 +Hemopoiesis بتحل محلها اللي هي الـ Malignant cells + +23 +00:01:51,350 --> 00:01:55,930 +اللي هي الـ Neoplastic blood cells هذا يؤدي لإيش؟ + +24 +00:01:55,930 --> 00:01:59,710 +لأن عدد الخلايا الـ Normal اللي المفروض تشتغل بشكل + +25 +00:01:59,710 --> 00:02:05,450 +طبيعي يقل ليش؟ لأنه حل محلها الخلايا الـ Malignant + +26 +00:02:06,340 --> 00:02:10,120 +طبعاً الخلايا الـ Normal مفروض بتعطيني RBCs مفروض + +27 +00:02:10,120 --> 00:02:13,840 +تعطيني Blood Cells White BCs بتعطيني Platelets + +28 +00:02:13,840 --> 00:02:18,840 +طبعاً هذا بينشأ عنه Bone Marrow Failure بشوف + +29 +00:02:18,840 --> 00:02:23,040 +Anemia نتيجة نقص الـ Production للـ RBCs + +30 +00:02:23,040 --> 00:02:26,880 +Neutropenia نتيجة نقص الـ Production للـ + +31 +00:02:26,880 --> 00:02:31,700 +Granulocyte بشوف Thrombocytopenia يعني بشوف Bone + +32 +00:02:31,700 --> 00:02:34,540 +Marrow Failure Marks + +33 +00:02:36,780 --> 00:02:42,000 +طيب الـ Blasts هذه بتغذو كل الـ + +34 +00:02:42,000 --> 00:02:45,140 +reticuloendothelial tissue زي الـ spleen، الـ + +35 +00:02:45,140 --> 00:02:50,090 +liver و الـ lymph nodes ممكن برضه تغزو أنسجة أخرى + +36 +00:02:50,090 --> 00:02:54,390 +وتعمل infiltration في organs متعددة من الجسم الـ + +37 +00:02:54,390 --> 00:02:57,070 +blast cells هذه يعني لا يقتصر وجودها على الـ bone + +38 +00:02:57,070 --> 00:03:00,530 +marrow ممكن بشكل أساسي في الـ bone marrow وفي الـ + +39 +00:03:00,530 --> 00:03:03,990 +reticuloendothelial system وقد تصل إلى أنسجة أخرى + +40 +00:03:03,990 --> 00:03:11,450 +بالجسم وتنتشر في مراحل متقدمة if left untreated لو + +41 +00:03:11,450 --> 00:03:13,310 +ما تعالجت اللوكيميا + +42 +00:03:17,210 --> 00:03:23,130 +الآن كيف بتتكون الـ acute leukemia عادة تتكون + +43 +00:03:23,130 --> 00:03:27,270 +نتيجة genetic alteration within a single stem cell + +44 +00:03:27,270 --> 00:03:32,470 +in the bone marrow بيصير خلل معين في stem cell في + +45 +00:03:32,470 --> 00:03:37,960 +الـ bone marrow الخلل هذا بينتج عنه block في الـ + +46 +00:03:37,960 --> 00:03:41,820 +maturation at certain level يعني مثلًا الخلية بدها + +47 +00:03:41,820 --> 00:03:45,200 +تمر بـ 5 مراحل من الـ maturation عشان توصل لـ + +48 +00:03:45,200 --> 00:03:49,820 +mature form ممكن توصل عند level 2 أو level 3 وتعمل + +49 +00:03:49,820 --> 00:03:55,000 +stop تمام؟ this reveals an abnormal regulatory + +50 +00:03:55,000 --> 00:03:59,380 +mechanism and the cell is incapable of further + +51 +00:03:59,380 --> 00:04:04,100 +differentiation يعني الآن في خلل الخلية هذه مش + +52 +00:04:04,100 --> 00:04:09,180 +قادرة تكمل الـ differentiation في خلل في عملية الـ + +53 +00:04:09,180 --> 00:04:12,780 +maturation المنظمة اللي بتصير قد يكون خلل في + +54 +00:04:12,780 --> 00:04:16,400 +transcription factors المهم عملية الـ regulation + +55 +00:04:16,400 --> 00:04:20,500 +تعتمد على الـ maturation بيصير لها stop أو بيصير فيها + +56 +00:04:20,500 --> 00:04:25,930 +defect فبالتالي الخلية ما تقدر تعمل maturation لكن + +57 +00:04:25,930 --> 00:04:31,110 +هذه الخلية تستمر لديها القدرة بالانقسام يعني بتظل + +58 +00:04:31,110 --> 00:04:36,370 +الخلية قادرة على إنها تنقسم فده إيش بينتج عنه؟ + +59 +00:04:36,370 --> 00:04:41,450 +انقسام Successive Mitotic Division انقسام سريع من + +60 +00:04:41,450 --> 00:04:45,070 +خلايا غير mature أو واقفة عند حد معين من الـ + +61 +00:04:45,070 --> 00:04:50,330 +Maturation هيطلع عندي Clonal Population مجموعة من + +62 +00:04:50,330 --> 00:04:55,620 +الخلايا نفس الـ Clone نفس المرحلة من الـ Maturation + +63 +00:04:55,620 --> 00:05:01,160 +هذا يعني هيؤدي إلى تراكمها بشكل كثير كبير وبتعمل + +64 +00:05:01,160 --> 00:05:06,820 +عندي Clonal Mass في ممكن أشوفها أنا سواء في الـ + +65 +00:05:06,820 --> 00:05:10,320 +Bone marrow أو بعد مراحل ممكن أشوفها في الـ + +66 +00:05:10,320 --> 00:05:12,780 +Peripheral blood وهي اللي بتعطى ال manifestation + +67 +00:05:12,780 --> 00:05:16,540 +للمرض يعني أنا مثلا بعرف اللوكيميا هذه مثلا هذه + +68 +00:05:16,540 --> 00:05:20,530 +نوع معين من اللوكيميا على سبيل المثال والتكنو تكن + +69 +00:05:20,530 --> 00:05:24,930 +M6 Acute Myeloid Leukemia 6 إيش الخلل فيها؟ بتكون + +70 +00:05:24,930 --> 00:05:28,310 +خلل في الـ Erythrite Series بيكون خلل في الـ + +71 +00:05:28,310 --> 00:05:32,390 +Maturation بتاعة الـ Erythrite مثلا لو أجيت مثلا + +72 +00:05:32,390 --> 00:05:36,270 +لـ M3 بلاقي الـ Predominant Cell الخلية اللي وقفت + +73 +00:05:36,270 --> 00:05:39,930 +عندها اللي هي الـ Promyelocyte فبعرف إنها هذه M3 + +74 +00:05:39,930 --> 00:05:45,040 +أو Promyelocytic Leukemia من هنا بتيجي تميزي + +75 +00:05:45,040 --> 00:05:48,100 +لأنواع اللوكيميا من الـ mass اللي اتكونت من + +76 +00:05:48,100 --> 00:05:52,120 +الخلايا اللي اتكونت بشكل كبير من نفس النوع ووقفة + +77 +00:05:52,120 --> 00:05:59,000 +عندها هذا بيخلينا نطلع في الـ two-hit model أنه + +78 +00:05:59,000 --> 00:06:05,340 +عشان يصير لوكيميا لازم يصير عندي طفرتين أول طفرة + +79 +00:06:05,340 --> 00:06:10,540 +أو أول خلل loss of function of transcription + +80 +00:06:10,540 --> 00:06:15,400 +factors needed for differentiation هي العوامل اللي + +81 +00:06:15,400 --> 00:06:19,660 +لازمة لتميز الخلايا طبعا هذا بيؤدي لـ + +82 +00:06:19,660 --> 00:06:23,300 +differentiation block لـ stop في ال + +83 +00:06:23,300 --> 00:06:27,700 +differentiation زي ما حكينا الخاصية التالية اللي + +84 +00:06:27,700 --> 00:06:31,720 +لازم تتوفر عشان يصير له لوكيميا أو الخلل الثاني اللي + +85 +00:06:31,720 --> 00:06:36,450 +لازم يتوفر Gain of function mutation of tyrosine + +86 +00:06:36,450 --> 00:06:41,430 +kinase يعني بتصير mutation الـ mutation هذه بتعمل + +87 +00:06:41,430 --> 00:06:47,090 +activation للـ tyrosine kinase مما يؤدي إلى زيادة + +88 +00:06:47,090 --> 00:06:50,530 +الـ mitotic division يعني زيادة الـ proliferation + +89 +00:06:50,530 --> 00:06:55,260 +إذا صار عندي differentiation blocked نتج نوع معين + +90 +00:06:55,260 --> 00:06:59,500 +من الخلايا ووقف النوع هذا ما وقفش وبس لأ هو + +91 +00:06:59,500 --> 00:07:05,080 +بيتكاثر أو الخلايا بتتكاثر بسرعة كبيرة مما أدى + +92 +00:07:05,080 --> 00:07:10,260 +لحدوث كمية كبيرة من الـ Undifferentiated self وأدى + +93 +00:07:10,260 --> 00:07:15,520 +إلى نتاج الـ Acute Leukemia نوع معين من أنواع + +94 +00:07:15,520 --> 00:07:19,220 +اللوكيميا حسب الخلية اللي وقف عندها الـ Maturation + +95 +00:07:23,710 --> 00:07:27,570 +هنا نتخيل الـ blood stream كيف بتتطور فيه + +96 +00:07:27,570 --> 00:07:32,070 +اللوكيميا طبعا أنتم عارفين أنه في البداية أي + +97 +00:07:32,070 --> 00:07:35,510 +mutation أو أي خلل بداية بيبين في الـ bone marrow + +98 +00:07:35,510 --> 00:07:38,710 +ولسه ما بكون شايفه في الـ peripheral blood + +99 +00:07:38,710 --> 00:07:42,770 +النتائج تبعته، هذا في المراحل الأولى، يعني في + +100 +00:07:42,770 --> 00:07:47,150 +المرحلة الأولى ممكن يبقى فيه خلل صاير في البون مارو + +101 +00:07:47,150 --> 00:07:52,270 +لكن ممكن أنا أجي أشوف Stage 1 الـ Blood Normal زي + +102 +00:07:52,270 --> 00:07:57,870 +وزي الـ Normal الـ WBCs الـ RBCs البلاتلتز كلياتها + +103 +00:07:57,870 --> 00:08:02,050 +بالوضع الطبيعي لها المرحلة الثانية اللي هي المرحلة + +104 +00:08:02,050 --> 00:08:06,430 +اللي بتتجاوز الـ bone marrow وبتبدأ تظهر البلاست + +105 +00:08:06,430 --> 00:08:10,510 +بأعداد قليلة في الـ peripheral blood فهذه هي + +106 +00:08:10,510 --> 00:08:14,610 +المرحلة اللي بتبدأ تظهر فيها أعراض اللوكيميا الـ + +107 +00:08:14,610 --> 00:08:20,450 +acute leukemia الآن تبدأ البلاست cells تغزو الـ + +108 +00:08:20,450 --> 00:08:26,500 +bone marrow المرحلة اللي بعدها تبدأ أعداد الـ Blast + +109 +00:08:26,500 --> 00:08:31,120 +Cells تزيد وتؤثر بشكل كبير على الخلايا الـ Normal + +110 +00:08:31,120 --> 00:08:35,080 +يعني لو أتينا لاحظنا صار تناقص ملحوظ في أعداد الـ + +111 +00:08:35,080 --> 00:08:38,320 +White Blood Cells الـ Normal صار تناقص في الـ RBC + +112 +00:08:38,320 --> 00:08:41,780 +صار تناقص في الـ Platelets هي المرحلة هذه اللي + +113 +00:08:41,780 --> 00:08:45,940 +بنشخص فيها أن هذه حالة لوكيميا المرحلة الرابعة اللي + +114 +00:08:45,940 --> 00:08:50,760 +هي أسوأ مرحلة أسوأ مرحلة زي ما أنتم شايفين أنه + +115 +00:08:50,760 --> 00:08:55,760 +الـ White BCs ما بضلش خالص كل اللي موجودة immature + +116 +00:08:55,760 --> 00:09:01,520 +فيه ضايل عندي RBCs بأعداد قليلة و Platelets بأعداد + +117 +00:09:01,520 --> 00:09:06,260 +قليلة هذه المرحلة سيئة طبعا بعد هيك إيش هيصير + +118 +00:09:06,260 --> 00:09:11,640 +هيغزو لـ BLAST كل الـ Peripheral Blood مش هلاقي + +119 +00:09:11,640 --> 00:09:18,100 +عندي تقريبا غير Blast وهذا يؤدي هذه Stage 5A يعني + +120 +00:09:18,100 --> 00:09:21,440 +أن الـ Blast غزت طبعا الـ Blast غزت هذه خلايا صحية + +121 +00:09:21,440 --> 00:09:25,460 +كتيرة لكن non-functional هيؤدي لإنه تدخل + +122 +00:09:25,460 --> 00:09:29,100 +الميكروبات اللي هي هذه باللون الأخضر الـ germ وتغزو + +123 +00:09:29,100 --> 00:09:33,540 +الـ blood وتعمل المضاعفات السيئة لللوكيميا، تمام؟ + +124 +00:09:33,540 --> 00:09:36,820 +هيك مراحل تطور اللوكيميا في الـ blood stream + +125 +00:09:41,870 --> 00:09:47,750 +طبعا عشان نتذكر مع بعض قلنا إنه في عندي + +126 +00:09:47,750 --> 00:09:52,970 +Hematopoietic stem cell في البونمارو هذه بتعطيني + +127 +00:09:52,970 --> 00:09:58,210 +lymphoid progenitor وبتعطيني myeloid progenitor + +128 +00:09:58,210 --> 00:10:03,750 +صح؟ الـ lymphoid بتكون منها اللي هي الـ B + +129 +00:10:03,750 --> 00:10:08,040 +-lymphocyte والـ T-lymphocyteالـ B-Lymphocyte زي + +130 +00:10:08,040 --> 00:10:11,420 +ما احنا عارفين في مراحل متقدمة بتتحول لـ Plasma + +131 +00:10:11,420 --> 00:10:15,220 +Cell عشان تكون الـ Antibody وبعد هيك الـ T + +132 +00:10:15,220 --> 00:10:18,000 +-Lymphocyte والـ T-Lymphocyte لها أنواعها + +133 +00:10:18,000 --> 00:10:23,400 +المتعددة هذا اللي هو الفرع اللي كون الـ Lymphoid + +134 +00:10:23,400 --> 00:10:27,720 +طيب الـ AML … عفواً الـ Myeloid الـ Myeloid هينتج + +135 +00:10:27,720 --> 00:10:34,270 +منها اللي هي الـ Granulocyte وهينتج منها الـ + +136 +00:10:34,270 --> 00:10:40,330 +Monocyte وهينتج منها الـ Platelets وهتنتج منها الـ + +137 +00:10:40,330 --> 00:10:45,770 +RBCs تمام؟ هطلع عندي في النهاية Neutrophil Eosinophil + +138 +00:10:45,770 --> 00:10:50,870 +Basophil هدول الـ Granulocyte بالإضافة للـ Monocyte + +139 +00:10:50,870 --> 00:10:56,030 +بالإضافة للـ Platelets بالإضافة للـ RBCs فأي خلل + +140 +00:10:56,030 --> 00:11:01,430 +في هدول بسمي اللوكيميا Acute Myeloid Leukemia الـ + +141 +00:11:01,430 --> 00:11:06,200 +Myeloid Precursor لو صار خلل في الـ lymphoid بسميها + +142 +00:11:06,200 --> 00:11:11,460 +acute lymphoid leukemia تمام هك؟ طبعا حسب الخلل + +143 +00:11:11,460 --> 00:11:15,140 +بنصنف اللوكيميا زي ما هنشوف لقدام في الشرايح + +144 +00:11:15,140 --> 00:11:20,820 +القادمة لو + +145 +00:11:20,820 --> 00:11:25,340 +أجينا نشوف التوزيع الديموغرافي لللوكيميا هنلاقي + +146 +00:11:25,340 --> 00:11:31,660 +أكتر نوع بيصير اللي هو الـ AML الـ acute myeloid + +147 +00:11:31,660 --> 00:11:38,560 +leukemia Acute Myeloid Leukemia بشكل 31% من حالات + +148 +00:11:38,560 --> 00:11:43,940 +اللوكيميا الـ Total بعد هيك بيجي وراها Chronic + +149 +00:11:43,940 --> 00:11:51,400 +Lymphoid Leukemia بتشكل 26% من الحالات بعد هيك + +150 +00:11:51,400 --> 00:12:00,130 +بتيجي عندي الـ CML بتشكل 15% من الحالات بعدين بتيجي + +151 +00:12:00,130 --> 00:12:06,810 +عند الـ ALL بتشكل 11% من مجموع الحالات بعدين الـ 17 + +152 +00:12:06,810 --> 00:12:12,790 +% اللي ضايلين هدول من أنواع لوكيميا متفرقة يعني + +153 +00:12:12,790 --> 00:12:19,130 +كلها بمجملها بتيجي 17% فهي تعتبر قليلة أو نادرة + +154 +00:12:19,130 --> 00:12:25,990 +الحدوث طيب + +155 +00:12:25,990 --> 00:12:32,240 +نيجي للـ Acute Leukemia Acute Leukemia أيش بنشوف + +156 +00:12:32,240 --> 00:12:37,900 +فيها في ال lab في المختبر أول حاجة بالنسبة للـ + +157 +00:12:37,900 --> 00:12:41,940 +Blood Examination طبعا يا بنات يعني الـ Acute + +158 +00:12:41,940 --> 00:12:45,260 +Leukemia بدنياكم تاخدوا قاعدة أنه يعني في + +159 +00:12:45,260 --> 00:12:48,380 +variation يعني حسب ال stage اللي بوصلني فيه المريض + +160 +00:12:48,380 --> 00:12:54,120 +هلاقي مراحل تطور المرض تنعكس على الـ CBC لإله ممكن + +161 +00:12:54,120 --> 00:12:57,310 +ألاقي المريض عنده أنيميا ممكن إذا كان في المراحل + +162 +00:12:57,310 --> 00:13:01,430 +الأولى ألاقي لسه مش صاير عنده أنيميا، تمام؟ بس إيش + +163 +00:13:01,430 --> 00:13:04,810 +المتوقع إنه ينتج عن الـ Acute Leukemia الأشياء + +164 +00:13:04,810 --> 00:13:10,390 +هذه؟ أنيميا، Thrombocytopenia، Variable Leukocyte + +165 +00:13:10,390 --> 00:13:13,970 +Count يعني مش شرط ألاقي الـ Leukocyte عشانها acute + +166 +00:13:13,970 --> 00:13:17,570 +عالية، لأ ممكن ألاقي فيه variation في الـ + +167 +00:13:17,570 --> 00:13:21,870 +Leukocyte Count ممكن تبقى عالية، غالبا بتكون عالية + +168 +00:13:21,870 --> 00:13:26,630 +لكن ممكن برضه ما تكونش عالية Blood Morphology لو + +169 +00:13:26,630 --> 00:13:30,530 +جيت أعمل Blood Film أكيد هلاقي Blast Cells وهذا + +170 +00:13:30,530 --> 00:13:33,430 +اللي بيميز الـ Acute Leukemia يعني هاد يخلوها + +171 +00:13:33,430 --> 00:13:39,190 +قاعدة أنه عشان أعتبر الخلية Acute أو أعتبر أن هذه + +172 +00:13:39,190 --> 00:13:44,390 +حالة Acute Leukemia لازم يكون عندي Blast Cells طب + +173 +00:13:44,390 --> 00:13:49,370 +قداش نسبة لـ Blast Cells في البون مرب نحكي الـ Bone + +174 +00:13:49,370 --> 00:13:53,110 +marrow morphology الـ Blast cells عشان أقول إنها + +175 +00:13:53,110 --> 00:13:57,550 +Acute لوكيميا لازم عدد لـ Blast cells يتجاوز الـ + +176 +00:13:57,550 --> 00:14:03,150 +20% فما فوق من عدد الـ White Blood Cells يعني عشان + +177 +00:14:03,150 --> 00:14:08,190 +تُعتبر Acute لوكيميا لازم يكون فيها Blast 20% فما + +178 +00:14:08,190 --> 00:14:12,310 +فوق أقل من هيك لا تُعتبر Acute لوكيميا ممكن تكون + +179 +00:14:12,310 --> 00:14:16,980 +Chronic أو ممكن تكون مشكلة تانية Submission of + +180 +00:14:16,980 --> 00:14:20,260 +Normal Hematopoiesis يعني لو أنا أجيت في ردد فيلم + +181 +00:14:20,260 --> 00:14:23,880 +«بون مارو» أتفرج عليه إن شاء الله إذا قدرنا ربنا + +182 +00:14:23,880 --> 00:14:27,260 +أه أنتوا شوفته في الـ «هيماتولوجيا» صحيح في أفلام + +183 +00:14:27,260 --> 00:14:32,420 +اللوكيميا هتلاقي الـ «بون مارو» Blast يعني نادر + +184 +00:14:32,420 --> 00:14:37,380 +لما بتلاقي mature cells خلايا mature أو خلايا + +185 +00:14:37,380 --> 00:14:40,320 +صيرلها Normal Maturation أو في الـ Normal + +186 +00:14:40,320 --> 00:14:43,240 +Maturation Stages العادية هتلاقي الـ «بون مارو» + +187 +00:14:43,240 --> 00:14:48,290 +معظمه Blast Cells بعد هيك بنيجي للفحوصات اللي + +188 +00:14:48,290 --> 00:14:51,670 +بنعملها الـ cytochemical stains حنحكي عنها ونرجعها + +189 +00:14:51,670 --> 00:14:55,610 +الـ immunophenotyping والـ cytogenetics والـ + +190 +00:14:55,610 --> 00:15:02,090 +molecular studies الأخرى الآن + +191 +00:15:02,090 --> 00:15:06,970 +راح نحكي عن ال classification of cells of immature + +192 +00:15:06,970 --> 00:15:09,610 +cells اللي بتتكون في اللوكيميا أو اللي بتصير في + +193 +00:15:09,610 --> 00:15:13,460 +اللوكيميا الـ Classification هذا ممكن يكون حسب أكتر + +194 +00:15:13,460 --> 00:15:15,800 +من شغلة ممكن يكون حسب الـ Morphology أو + +195 +00:15:15,800 --> 00:15:18,500 +الـ Cytochemistry أو الـ Immunophenotyping أو + +196 +00:15:18,500 --> 00:15:22,500 +الـ Cytogenetics يعني في أشياء كتير ممكن نعمل + +197 +00:15:22,500 --> 00:15:24,500 +Classification على حسبها وتساعدني في + +198 +00:15:24,500 --> 00:15:27,300 +الـ Classification للخلايا الآن نيجي إلى + +199 +00:15:27,300 --> 00:15:32,520 +الـ Morphology الآن أول حاجة يعني قدامي Blast Cell + +200 +00:15:32,520 --> 00:15:37,260 +أول حاجة بدي أطلع على حجم الـ Blast Size ممكن + +201 +00:15:37,260 --> 00:15:41,620 +يعطيني Indication على نوع الـ Blast The amount of + +202 +00:15:41,620 --> 00:15:45,420 +cytoplasm كمية الـ «cytoplasm» والله مثلا الـ + +203 +00:15:45,420 --> 00:15:49,540 +«cytoplasm» كميته كبيرة معنى الكلام إن هذه الـ + +204 +00:15:49,540 --> 00:15:54,240 +«blast» بادي يصيرلها «maturation» إذا كان لسه الـ + +205 +00:15:54,240 --> 00:15:57,340 +«cytoplasm» كميته ضئيلة جداً لسه هي «early blast» + +206 +00:15:57,340 --> 00:16:02,840 +بتكون «the nuclear chromatin pattern» احنا عارفين + +207 +00:16:02,840 --> 00:16:06,900 +إن مع الـ «maturation» الـ «nuclear material» + +208 +00:16:06,900 --> 00:16:10,670 +بتصير «coarser» يعني في الـ Early Blast بتكون الـ + +209 +00:16:10,670 --> 00:16:14,330 +chromatin material very fine طيب، هل هي لازالت + +210 +00:16:14,330 --> 00:16:17,990 +fine ولا بلشت تصير more mature؟ هل صار الـ + +211 +00:16:17,990 --> 00:16:22,150 +chromatin material coarse أكتر؟ هل في مثلا الـ + +212 +00:16:22,150 --> 00:16:26,710 +nucleoli طبعاً وجود الـ nucleoli أو اختفاءها، عدم + +213 +00:16:26,710 --> 00:16:29,830 +ظهورها يعني بدل على الـ maturation كل ما كانت + +214 +00:16:29,830 --> 00:16:33,570 +الخلية mature أكتر أو الـ blast mature أكتر هتبدأ + +215 +00:16:33,570 --> 00:16:36,270 +الـ coarse chromatin material تغطي الـ nucleoli + +216 +00:16:36,270 --> 00:16:40,900 +وبطل أشوفها هل في Auer rods دايمًا الـ Auer rods بتدل + +217 +00:16:40,900 --> 00:16:44,520 +على إنه myeloid مش lymphoid مثلًا إنه الخلايا هذه + +218 +00:16:44,520 --> 00:16:48,200 +أصلها من الـ myeloid precursor أشوف Auer rod برفع + +219 +00:16:48,200 --> 00:16:52,940 +من بالي خالص فكرة الـ lymphoid Auer rod إيش هي؟ الـ + +220 +00:16:52,940 --> 00:16:57,620 +Auer rod هو يعني إذا كنتوا فاكرين هو تجمع من الـ + +221 +00:16:57,620 --> 00:17:00,960 +azurophillic granules على شكل الـ rod Auer rods are + +222 +00:17:00,960 --> 00:17:06,300 +often seen as being slender, splinter shape inclusion due to a + +223 +00:17:06,300 --> 00:17:09,980 +rod shape alignment of primary granules found only + +224 +00:17:09,980 --> 00:17:14,160 +in myeloproliferative processes يعني هي عبارة عن + +225 +00:17:14,160 --> 00:17:18,240 +تجمع وارتباط يمكن تلاقيها على شكل عصاية رد صغير من + +226 +00:17:18,240 --> 00:17:21,140 +الـ primary أو الـ azurophillic granules موجودة في + +227 +00:17:21,140 --> 00:17:27,520 +الـ myeloid precursor عندي هنا صورة myeloblast + +228 +00:17:27,520 --> 00:17:31,900 +موجود فيها أول رد زي ما أنتوا شايفين myeloblast + +229 +00:17:32,240 --> 00:17:38,220 +عبارة عن Large Blast with moderate amount of + +230 +00:17:38,220 --> 00:17:42,860 +cytoplasm فيه cytoplasm chromatin material fine + +231 +00:17:42,860 --> 00:17:46,600 +بشوف فيها نيوكليولاي زي ما انتوا شايفين هي + +232 +00:17:46,600 --> 00:17:53,800 +نيوكليولاي واضحة تقريبا من 10 إلى 40% من الـ + +233 +00:17:53,800 --> 00:17:57,880 +Myeloid precursor من الـ Myeloblast يعني بلاقي + +234 +00:17:57,880 --> 00:18:02,440 +فيها الـ Auer rods هي الـ Auer rods واضحين في الـ Cytoplasm زي + +235 +00:18:02,440 --> 00:18:06,760 +ما انتوا شايفين هذه الـ Auer rods في الـ Cytoplasm إذن + +236 +00:18:06,760 --> 00:18:11,840 +إذا أنا شوفت Auer rods بستفني الـ Lymphoid precursors + +237 +00:18:11,840 --> 00:18:16,440 +نهائيًا Myeloid هي أو Myeloblast هي اللي بشوف فيها + +238 +00:18:16,440 --> 00:18:24,680 +الـ Auer rods نيجي + +239 +00:18:24,680 --> 00:18:29,360 +للـ Lymphoid الـ Lymphoid الـ Lymphoblast عبارة عن + +240 +00:18:29,360 --> 00:18:34,700 +إلى حد ما بلاست أصغر With scant cytoplasm كمية الـ + +241 +00:18:34,700 --> 00:18:38,780 +cytoplasm قليلة شحيحة جدا Chromatin material إلى + +242 +00:18:38,780 --> 00:18:45,300 +حد ما بيبقى dense النوية مش دائما بتكون كتير واضحة + +243 +00:18:45,300 --> 00:18:49,180 +أو الـ Auer rods مش موجودة خالص أو الـ Auer rods مش موجودة + +244 +00:18:49,180 --> 00:18:53,080 +خالص هذه الـ lymphoblast برضه بعود بذكركم يا بنات + +245 +00:18:53,080 --> 00:18:58,180 +أنه الـ lymphoblast من myeloblast حتى لو كنت أنا + +246 +00:18:58,180 --> 00:19:02,340 +خبيرة جداً لازم أفصل بينهم بالـ «cytochemical + +247 +00:19:02,340 --> 00:19:07,180 +stains» اللي هنذكرها مع بعضنا أدنا اللي هي + +248 +00:19:07,180 --> 00:19:09,660 +الـ myeloperoxidase و «السودان البلاك» وهدول اللي + +249 +00:19:09,660 --> 00:19:13,060 +هنرجعهم إن شاء الله رب العالمين مع بعض بمعنى إنه + +250 +00:19:13,060 --> 00:19:17,140 +مهما كنت أنا expert ما بقدر 100% أقول إن هذه + +251 +00:19:17,140 --> 00:19:21,220 +myeloblast أو lymphoblast أنا بتوقع تمام بعد هيك + +252 +00:19:21,220 --> 00:19:24,220 +بأكد بالـ«cytochemical stains» أو + +253 +00:19:24,220 --> 00:19:25,500 +بالـ«immunophenotyping» + +254 +00:19:29,100 --> 00:19:33,780 +هنيجي لتصنيفات اللوكيميا طبعاً احنا عارفين إن + +255 +00:19:33,780 --> 00:19:37,060 +اللوكيميا قد تكون chronic أو acute سواء chronic أو + +256 +00:19:37,060 --> 00:19:41,060 +acute هتكون lymphoid أو myeloid الـ acute-leukemia + +257 +00:19:41,060 --> 00:19:46,100 +تم تصنيفها بناء على دراسات يعني استخدمت الدراسات + +258 +00:19:46,100 --> 00:19:49,720 +هذه الـ morphology مع الـ cytochemical standard تم + +259 +00:19:49,720 --> 00:19:54,620 +تصنيفها إلى lymphoid and myeloid تمام، الـ + +260 +00:19:54,620 --> 00:20:00,280 +lymphoid تم تقسيمها من M0 إلى M7، والمفايد تم + +261 +00:20:00,280 --> 00:20:05,520 +تقسيمها من الـ 1 إلى الـ 3، راح نراشدهم مع بعض كيف + +262 +00:20:05,520 --> 00:20:15,240 +بعمل دا، طيب ميجي الـ ALL، الـ ALL عادة بتتم تصنيفها + +263 +00:20:15,240 --> 00:20:20,520 +حسب الفئة بـ classification إلى 3 أنواع، الـ 1، الـ + +264 +00:20:20,520 --> 00:20:27,140 +2، الـ 3 بالـ «Morphology» العادي بدون استخدام أصباغ + +265 +00:20:27,140 --> 00:20:30,960 +تانية بدون استخدام «Cytochemical Stains» يعني + +266 +00:20:30,960 --> 00:20:34,540 +بصبغة الـ «Hematologist Stain» العادية، إيش بشوف؟ + +267 +00:20:34,540 --> 00:20:38,840 +بشوف الألوان الخلايا عبارة عن «Small Blast» + +268 +00:20:38,840 --> 00:20:42,720 +«Homogeneous» أو «Uniform Size»، يعني بتحس إن كل + +269 +00:20:42,720 --> 00:20:45,740 +الـ «Blood Film» أو كل الـ «Blast» الموجود عندك في + +270 +00:20:45,740 --> 00:20:48,120 +الـ «Blood Film» أو في الـ «Bone Marrow Film» + +271 +00:20:48,120 --> 00:20:52,570 +هتلاقيها كلها نفس الحجم تقريبا أو متقاربة جداً، الـ + +272 +00:20:52,570 --> 00:20:56,790 +Cytoplasm قليل، Scanty Cytoplasm، النوات بتاعتها بتكون + +273 +00:20:56,790 --> 00:21:02,050 +Round، Small، Enucleolus، أحياناً بشوف فيها Small + +274 +00:21:02,050 --> 00:21:08,190 +Enucleolite، تمام؟ هذه بتشكل 75% من الـ ALL cases + +275 +00:21:08,190 --> 00:21:12,910 +بتشكل 75% من حالات الـ Acute Lymphoid Leukemia + +276 +00:21:12,910 --> 00:21:20,550 +نيجي لـ L2، L2 بتتميز الخلايا بأنها Large، Irregular + +277 +00:21:20,550 --> 00:21:23,830 +Size، يعني بتلاقي أكتر من Size في الـ Blood Film + +278 +00:21:23,830 --> 00:21:28,970 +يعني هذه في الـ L1 كنا نقول تقريبا كلهم نفس الحجم، + +279 +00:21:28,970 --> 00:21:33,630 +هنا لأ، هتلاقي خلايا heterogeneous، في خلايا كبيرة، + +280 +00:21:33,630 --> 00:21:38,090 +في خلايا صغيرة بالإضافة لأن كمية الـ Cytoplasm + +281 +00:21:38,090 --> 00:21:42,590 +هتلاقيها شوية أكبر، الـ Nucleus بتلاقيها برضه + +282 +00:21:42,590 --> 00:21:46,790 +Irregular، و الـ Nucleoli برضه ممكن تشوفيها واضحة + +283 +00:21:46,790 --> 00:21:48,590 +تمام؟ + +284 +00:21:52,750 --> 00:21:59,370 +التلاتة، التلاتة تتميز بأنها كبيرة لكن uniform، صحيح + +285 +00:21:59,370 --> 00:22:03,230 +هي كبيرة لكن بتلاقي الأحجام متقاربة، abundance of + +286 +00:22:03,230 --> 00:22:05,950 +cytoplasm، الـ cytoplasm تبعها بيبقى كبير برضه + +287 +00:22:05,950 --> 00:22:11,330 +بنلاحظ وجود vacuoles فيها، هذه الـ vacuoles عبارة + +288 +00:22:11,330 --> 00:22:17,670 +عن vacuoles موجود فيها fats، lipids وتعطيها هذه + +289 +00:22:17,670 --> 00:22:20,270 +خاصية الصباغة بالـ sudan black زي ما عندنا هنشوف + +290 +00:22:21,240 --> 00:22:26,920 +الـ nucleus بتاعتها round، نيوكليولاي واضحة، الـ L2 + +291 +00:22:26,920 --> 00:22:35,060 +بتشكل 20%، الـ L3 بتشكل تقريباً + +292 +00:22:35,060 --> 00:22:44,080 +5% من الـ total ALL cases، طيب + +293 +00:22:44,080 --> 00:22:49,450 +نيجي للـ acute lymphoblastic leukemia L1، الـ 1 + +294 +00:22:49,450 --> 00:22:55,070 +ناخدهم واحدة واحدة بالتفصيل، الـ 1 is the most + +295 +00:22:55,070 --> 00:22:59,330 +common form found in children and it has the best + +296 +00:22:59,330 --> 00:23:02,330 +prognosis، يعني أفضل واحدة من ناحية الـ prognosis + +297 +00:23:02,330 --> 00:23:06,570 +the cell size is small with fine or clumped + +298 +00:23:06,570 --> 00:23:10,250 +homogeneous nuclear chromatin and absent or + +299 +00:23:10,250 --> 00:23:14,890 +indistinct nuclei، يعني ممكن أشوف nuclei بس مش كتير + +300 +00:23:14,890 --> 00:23:18,570 +واضحة، قالتوا إذا كنتوا فاكرينه، قالت لأ تكنت الـ + +301 +00:23:18,570 --> 00:23:25,430 +Nuclear Lie فيهم أوضح، طيب الـ Nuclear shape is + +302 +00:23:25,430 --> 00:23:33,480 +regular، الخلية النوة بتاعتها يعني بتكون منتظمة، ممكن + +303 +00:23:33,480 --> 00:23:39,540 +تبقى oval، عفوًا، ممكن تبقى rounded وفيها إكلفت بسيط + +304 +00:23:39,540 --> 00:23:43,640 +أو indentation، يعني هتلاقي فيها نطوق صغير في داخل + +305 +00:23:43,640 --> 00:23:47,560 +جاي هيك داخل لجوا في الـ nucleus، الـ cytoplasm + +306 +00:23:47,560 --> 00:23:52,460 +بتاعتها هيكون slight to moderate بيزوفيليا، هتلاقيه + +307 +00:23:52,460 --> 00:23:56,780 +بيزوفيليك وكميته قليلة، الـ L2 + +308 +00:24:03,060 --> 00:24:09,280 +زي ما أنتم لاحظين، خلايا أول حاجة بنلاحظها مش + +309 +00:24:09,280 --> 00:24:14,180 +متجانسة، L2، the most frequent found in adult + +310 +00:24:14,180 --> 00:24:17,840 +بنلاقيها في الـ Adult، مش في الأصغار، الـ cell size + +311 +00:24:17,840 --> 00:24:20,700 +is large and heterogeneous with variable in + +312 +00:24:20,700 --> 00:24:23,900 +nuclear chromatin and prominent nuclei، بشوف فيها + +313 +00:24:23,900 --> 00:24:29,500 +nuclei أوضح من ألوان الـ nucleus is irregular، إن + +314 +00:24:29,500 --> 00:24:34,070 +واتعتها irregular، بلاقي فيها Clift بسيط and + +315 +00:24:34,070 --> 00:24:39,130 +Intended، يعني بتلاقي فيها Clift بسيط وداخل لجوه + +316 +00:24:39,130 --> 00:24:43,170 +هيك، وعادة هي مش منتظمة، بالشكل الـCytoplasm is + +317 +00:24:43,170 --> 00:24:46,690 +variable and often moderate to abundant، يعني ممكن + +318 +00:24:46,690 --> 00:24:51,050 +أشوف Cytoplasm فيها متوسط أو كميته كبيرة على خلاف + +319 +00:24:51,050 --> 00:24:56,090 +ألوان اللي بيكون الـCytoplasm فيها قليل، الـ + +320 +00:24:56,090 --> 00:24:59,550 +Cytoplasm بيبقى Basophilic، إذا الفرق اللي لاحظناه + +321 +00:24:59,550 --> 00:25:03,570 +بين L1 وL2، L1 كانت الخلايا أهم حاجة خلايا صغيرة + +322 +00:25:03,570 --> 00:25:07,610 +متجانسة، Cytoplasm تبعها قليل، هنا خلايا كبيرة غير + +323 +00:25:07,610 --> 00:25:11,950 +متجانسة وغير منتظمة، الـ Cytoplasm لإلها أكتر من + +324 +00:25:11,950 --> 00:25:19,890 +الـ L1، L3 + +325 +00:25:22,390 --> 00:25:27,510 +L3 أقل واحدة، Under واحدة بتشكل بس 5% من مجموع + +326 +00:25:27,510 --> 00:25:32,330 +الحالات، الخلايا بتكون فيها كبيرة، الـ Nuclear + +327 +00:25:32,330 --> 00:25:37,330 +Chromatin Material هنلاقي … هنلاقي Homogeneous، الـ + +328 +00:25:37,330 --> 00:25:41,550 +Nucleoli بتكون فيها واضحة، طبعاً إنها بتاعتها + +329 +00:25:41,550 --> 00:25:46,330 +Large، Oval أو Rounded، الـ Cytoplasm بلاقي كميته + +330 +00:25:46,330 --> 00:25:49,990 +متوسطة إلى كثيرة، بلاقي فيه الـ Vacuoles الواضحة + +331 +00:25:49,990 --> 00:25:54,380 +هذه طبعاً الـ Vacuoles هذه،عادةً بتدلل على إنها هذه + +332 +00:25:54,380 --> 00:25:59,740 +التلاتة لأنها هي Fat Vacuoles، لما هاجي أعمل صباغة + +333 +00:25:59,740 --> 00:26:03,840 +بالفيلم العادي بتدوب الفات لأن أنا بعمل Fixation + +334 +00:26:03,840 --> 00:26:07,360 +بالإيثانال أو بالميثانال، لما بعمل Fixation هيدوّب + +335 +00:26:07,360 --> 00:26:12,680 +الكحول فهيترك مكانه فجوات غير مصبوغة، ليش؟ لأنه + +336 +00:26:12,680 --> 00:26:16,520 +فقدت هذه الأماكن أو المحتوى تبعها ذهب وراه مع + +337 +00:26:16,520 --> 00:26:19,620 +الكحول خلال الـFixation، علشان أكي بشوف الـVacuoles + +338 +00:26:19,620 --> 00:26:22,980 +هذه كان مفروض فيها فات، لكن هي الآن بيانات فارغة + +339 +00:26:22,980 --> 00:26:28,240 +نيجي + +340 +00:26:28,240 --> 00:26:34,160 +لبعض المعلومات العامة عن الـ ALL، عادة هي بتصيب الـ + +341 +00:26:34,160 --> 00:26:38,440 +Children من سنتين إلى خمس سنوات، وطبعاً قد تصيب الـ + +342 +00:26:38,440 --> 00:26:43,620 +Adult، الـ Clinical Finding لها يعني أول حاجة الـ + +343 +00:26:43,620 --> 00:26:51,540 +Symptoms العامة زي بالر، شحوب، زي مثلًا Wet loss، + +344 +00:26:51,540 --> 00:26:55,620 +fever، Irritability، Anorexia، Infection، bleeding، + +345 +00:26:55,620 --> 00:26:59,980 +and wound pain، طبعًا بان سايتوبينيا، بان سايتوبينيا + +346 +00:26:59,980 --> 00:27:04,400 +لأنه فيه ineffective hemobiasis، فهتلاقي أنه الـ + +347 +00:27:04,400 --> 00:27:06,880 +Blatelets هتنزل، الـ white bases اللي هي الـ + +348 +00:27:06,880 --> 00:27:09,300 +functional، ال mature white bases هيصير فيها + +349 +00:27:09,300 --> 00:27:13,680 +deficiency اللي هي مسؤولة عن المقاومة ضد ال + +350 +00:27:13,680 --> 00:27:16,980 +infection، فعشان هيصير infection، حيصير الـ bleeding + +351 +00:27:16,980 --> 00:27:21,200 +نتيجة الـ pancytopemia، حيصير شخوب نتيجة أن الـ + +352 +00:27:21,200 --> 00:27:25,000 +RBCs ما بتنتج كويس، فحيصير أنيميا، Bone pain طبعاً + +353 +00:27:25,000 --> 00:27:28,360 +نتيجة الـ stimulation بتاع الـ bone marrow وزيادة + +354 +00:27:28,360 --> 00:27:32,280 +التصنيع للـ abnormal cells، عادة الـ one بتصير عند + +355 +00:27:32,280 --> 00:27:35,100 +الأطفال، الـ two عند الـ adult، الـ ثلاثة تسمى + +356 +00:27:46,390 --> 00:27:51,650 +فبنلاقي المرضى اللي ما بين سنة إلى تلتاشر سنة هدول + +357 +00:27:51,650 --> 00:27:57,890 +أفضل، أفضل Prognosis، تمام؟ اللي أقل من سنة وأكتر من + +358 +00:27:57,890 --> 00:28:02,890 +تلتاشر هدول ال Prognosis اللي لهم بور سيء، يعني ممكن + +359 +00:28:02,890 --> 00:28:09,390 +من سنة إلى تلتاشر يتعافوا من اللوكينيا الـ ALL، طيب + +360 +00:28:09,390 --> 00:28:12,670 +نيجي للـ White BCs Count، طبعا الـ White BCs Count + +361 +00:28:13,200 --> 00:28:18,620 +كل مزاد بدل على أنه المرض في مراحل متقدمة أكتر + +362 +00:28:18,620 --> 00:28:24,460 +والحالة أنشط، إذا كان الـ YPCs count أقل من 10 ألاف + +363 +00:28:24,460 --> 00:28:29,620 +عند الـ diagnosis، الـ prognosis بيكون أفضل إذا كان + +364 +00:28:29,620 --> 00:28:34,380 +فوق العشرين ألف، غالباً الـ prognosis poor، تمام + +365 +00:28:34,380 --> 00:28:41,100 +الشغل التالتة المهمة برضه اللي هي الـ + +366 +00:28:42,630 --> 00:28:46,330 +الخلية اللي موجودة أو الـ Predominant Cell، إذا + +367 +00:28:46,330 --> 00:28:51,390 +كانت T cell، T cell عادة بتكون أكثر شيوعا عند المال + +368 +00:28:51,390 --> 00:28:56,970 +التيسل، بورر الـ Prognosis، بورر الـ Prognosis يعني + +369 +00:28:56,970 --> 00:29:00,410 +الـ Prognosis بتاعك ليش؟ لأن T cell يبقى وظائفها + +370 +00:29:00,410 --> 00:29:06,950 +أكتر أصلا من الـ B cell في الجسم، طيب الـ B cell + +371 +00:29:08,270 --> 00:29:12,910 +عادة يعني ممكن يصير معدل شفاء 70% من الناس اللي + +372 +00:29:12,910 --> 00:29:17,630 +عندهم ALL والـ diagnosis كان بـ cell أو المشكلة + +373 +00:29:17,630 --> 00:29:22,410 +كانت جاية من الـ B cell، يعني الـ B cell الـ + +374 +00:29:22,410 --> 00:29:23,550 +prognosis تبعها أفضل diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/CynxsWy4c3I_raw.json b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/CynxsWy4c3I_raw.json new file mode 100644 index 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+00:00:10,310 --> 00:00:17,090 +باللوكيميا بأنواعها وتصنيفها طبعا إحنا عارفين إن + +4 +00:00:17,090 --> 00:00:21,610 +اللوكيميا تنقسم إلى قسمين رئيسيات قد تكون + +5 +00:00:21,610 --> 00:00:26,900 +اللوكيميا acute وقد تكون chronic راح ناخدكل + +6 +00:00:26,900 --> 00:00:30,820 +التفاصيل بتاعت الـ classification والـ diagnosis + +7 +00:00:30,820 --> 00:00:35,580 +لكل نوع من هذه الأنواع سواء كانت acute أو chronic + +8 +00:00:35,580 --> 00:00:40,360 +بداية نحكي مقدمة بسيطة عن الـ acute leukemia إيش + +9 +00:00:40,360 --> 00:00:44,350 +هي الـ acute leukemia what is acute leukemiaالـ + +10 +00:00:44,350 --> 00:00:48,550 +Acute Leukemia عبارة عن group of malignant + +11 +00:00:48,550 --> 00:00:53,950 +disorders مجموعة من الـ malignant disorders والتي + +12 +00:00:53,950 --> 00:00:59,390 +تتميز بأنه بصير فيها uncontrolled clonal + +13 +00:00:59,390 --> 00:01:06,710 +proliferation لنوع من الخلايا and accumulation of + +14 +00:01:06,710 --> 00:01:10,150 +poorly differentiated blast cells in the bone + +15 +00:01:10,150 --> 00:01:13,750 +marrow and other tissueblast cells بيصيرلها + +16 +00:01:13,750 --> 00:01:20,030 +uncontrolled proliferation يعني بيصير تتكاثر + +17 +00:01:20,030 --> 00:01:26,810 +بطريقة غير مسبوقة مما يؤدي لتراكم هذه الخلايا في + +18 +00:01:26,810 --> 00:01:34,050 +البونمارو والأنسجاء الأخرى طبعا، الآن هذه الخلايا + +19 +00:01:34,050 --> 00:01:38,990 +لما يزيد عددها في البونمارو إيش بينتج عنهاك؟تعمل + +20 +00:01:38,990 --> 00:01:43,950 +Replacement of bone marrow normal elements يعني + +21 +00:01:43,950 --> 00:01:47,230 +الخلايا الطبيعية في البون مارو المسؤولة عن الـ + +22 +00:01:47,230 --> 00:01:51,350 +Hemopoiesis بتحل محلها اللي هي الـ Malignant cells + +23 +00:01:51,350 --> 00:01:55,930 +اللي هي الـ Neoplastic blood cells هذا يؤدي لإيش؟ + +24 +00:01:55,930 --> 00:01:59,710 +لأن عدد الخلايا الـ Normal اللي المفروض تشتغل بشكل + +25 +00:01:59,710 --> 00:02:05,450 +طبيعي يقل ليش؟ لأنه حل محلها الخلايا الـ Malignant + +26 +00:02:06,340 --> 00:02:10,120 +طبعاً الخلايا الـ Normal مفروض بتعطيني RBCs مفروض + +27 +00:02:10,120 --> 00:02:13,840 +تعطيني Blood Cells White BCs بتعطيني Platelets + +28 +00:02:13,840 --> 00:02:18,840 +طبعاً هذا بينشأ عنه Bone Marrow Failure بشوف + +29 +00:02:18,840 --> 00:02:23,040 +Anemia نتيجة نقص الـ Production للـ RBCs + +30 +00:02:23,040 --> 00:02:26,880 +Neutropenia نتيجة نقص الـ Production للـ + +31 +00:02:26,880 --> 00:02:31,700 +Granulocyte بشوف Thrombocytopenia يعني بشوف Bone + +32 +00:02:31,700 --> 00:02:34,540 +Marrow Failure Marks + +33 +00:02:36,780 --> 00:02:42,000 +طيب الـ Blasts هذه بتغذو كل الـ + +34 +00:02:42,000 --> 00:02:45,140 +reticuloendothelial tissue زي الـ spleen، الـ + +35 +00:02:45,140 --> 00:02:50,090 +liver و الـ lymph nodesممكن برضه تغزو أنسجة أخرى + +36 +00:02:50,090 --> 00:02:54,390 +وتعمل infiltration في organs متعددة من الجسم الـ + +37 +00:02:54,390 --> 00:02:57,070 +blast cells هذه يعني لا يقتصر وجودها على الـ bone + +38 +00:02:57,070 --> 00:03:00,530 +marrow ممكن بشكل أساسي في الـ bone marrow وفي الـ + +39 +00:03:00,530 --> 00:03:03,990 +reticuloendothelial system وقد تصل إلى أنسجة أخرى + +40 +00:03:03,990 --> 00:03:11,450 +بالجسم وتنتشر في مراحل متقدمة if left untreated لو + +41 +00:03:11,450 --> 00:03:13,310 +ما تعالجت اللوكيميا + +42 +00:03:17,210 --> 00:03:23,130 +الآن كيف بتتكون الـ acute leukemia عادة تتكون + +43 +00:03:23,130 --> 00:03:27,270 +نتيجة genetic alteration within a single stem cell + +44 +00:03:27,270 --> 00:03:32,470 +in the bone marrow بيصير خلل معين في stem cell في + +45 +00:03:32,470 --> 00:03:37,960 +الـ bone marrow الخلل هذا بينتج عنه blockفي الـ + +46 +00:03:37,960 --> 00:03:41,820 +maturation at certain level يعني مثلًا الخلية بدها + +47 +00:03:41,820 --> 00:03:45,200 +تمر بـ 5 مراحل من الـ maturation عشان توصل لـ + +48 +00:03:45,200 --> 00:03:49,820 +mature form ممكن توصل عند level 2 أو level 3 وتعمل + +49 +00:03:49,820 --> 00:03:55,000 +stop تمام؟ this reveals an abnormal regulatory + +50 +00:03:55,000 --> 00:03:59,380 +mechanism and the cell is incapable of further + +51 +00:03:59,380 --> 00:04:04,100 +differentiation يعني الآن في خللالخلية هذه مش + +52 +00:04:04,100 --> 00:04:09,180 +قادرة تكمل الـ differentiation في خلل في عملية الـ + +53 +00:04:09,180 --> 00:04:12,780 +maturation المنظمة اللي بتصير قد يكون خلل في + +54 +00:04:12,780 --> 00:04:16,400 +transcription factors المهم عملية الـ regulation + +55 +00:04:16,400 --> 00:04:20,500 +تعت الـ maturation بيصير لها stop أو بيصير فيها + +56 +00:04:20,500 --> 00:04:25,930 +defect فبالتالي الخلية ما تقدر تعمل maturationلكن + +57 +00:04:25,930 --> 00:04:31,110 +هذه الخلية تستمر لديها القدرة بالانقسام يعني بتظل + +58 +00:04:31,110 --> 00:04:36,370 +الخلية قادرة على إنها تنقسم فده إيش بينتج عنه؟ + +59 +00:04:36,370 --> 00:04:41,450 +انقسام Successive Mitotic Division انقسام سريع من + +60 +00:04:41,450 --> 00:04:45,070 +خلايا غير mature أو واقفة عند حد معين من الـ + +61 +00:04:45,070 --> 00:04:50,330 +Maturation هيطلّع عندي Clonal Population مجموعة من + +62 +00:04:50,330 --> 00:04:55,620 +الخلايا نفس الـCloneنفس المرحلة من الـ Maturation + +63 +00:04:55,620 --> 00:05:01,160 +هذا يعني هيؤدى إلى تراكمها بشكل كتير كبير وبتعمل + +64 +00:05:01,160 --> 00:05:06,820 +عندى Clonal Mass في ممكن أشوفها أنا سواء في الـ + +65 +00:05:06,820 --> 00:05:10,320 +Bone marrow أو بعد مراحل ممكن أشوفها في الـ + +66 +00:05:10,320 --> 00:05:12,780 +Peripheral blood وهى اللى بتعطى ال manifestation + +67 +00:05:12,780 --> 00:05:16,540 +للمرض يعني أنا مثلا بعرف اللوكيميا هذه مثلا هذه + +68 +00:05:16,540 --> 00:05:20,530 +نوع معين من اللوكيميا على سبيل المثال والتكنولتكن + +69 +00:05:20,530 --> 00:05:24,930 +M6 Acute Myeloid Leukemia 6 إيش الخلل فيها؟ بتكون + +70 +00:05:24,930 --> 00:05:28,310 +خلل في الـ Erythrite Series بيكون خلل في الـ + +71 +00:05:28,310 --> 00:05:32,390 +Maturation بتاعة الـ Erythrite مثلا لو أجيت مثلا + +72 +00:05:32,390 --> 00:05:36,270 +لـ M3 بلاقي الـ Predominant Cell الخلية اللي وقفت + +73 +00:05:36,270 --> 00:05:39,930 +عندها اللي هي الـ Bromielocyte فبعرف إنها هذه M3 + +74 +00:05:39,930 --> 00:05:45,040 +أو Bromielocytic Leukemia من هنا بتيجيتمييزي + +75 +00:05:45,040 --> 00:05:48,100 +لأنواع اللوكيميا من الـ mass اللي اتكونت من + +76 +00:05:48,100 --> 00:05:52,120 +الخلايا اللي اتكونت بشكل كبير من نفس النوع ووقفة + +77 +00:05:52,120 --> 00:05:59,000 +عندها هذا بيخلينا نطلع في الـ two-hit model أنه + +78 +00:05:59,000 --> 00:06:05,340 +عشان يصير لوكيميا لازم يصير عندى طفرتين أول طفرة + +79 +00:06:05,340 --> 00:06:10,540 +أو أول خلل loss of functionof transcription + +80 +00:06:10,540 --> 00:06:15,400 +factors needed for differentiation هي العوامل اللي + +81 +00:06:15,400 --> 00:06:19,660 +لازمة لتميز الخلايا طبعا هذا بيؤدي لـ + +82 +00:06:19,660 --> 00:06:23,300 +differentiation block لـ stop في ال + +83 +00:06:23,300 --> 00:06:27,700 +differentiation زي ما حكينا الخاصية التالية اللي + +84 +00:06:27,700 --> 00:06:31,720 +لازم تتوفر عشان يصيرله كيميا أو الخلل التاني اللي + +85 +00:06:31,720 --> 00:06:36,450 +لازم يتوفرGain of function mutation of tyrosine + +86 +00:06:36,450 --> 00:06:41,430 +kinase يعني بتصير mutation الـ mutation هذه بتعمل + +87 +00:06:41,430 --> 00:06:47,090 +activation للـ tyrosine kinase مما يؤدي إلى زيادة + +88 +00:06:47,090 --> 00:06:50,530 +الـ mitotic division يعني زيادة الـ proliferation + +89 +00:06:50,530 --> 00:06:55,260 +إذا صار عندى differentiation blockedنتج نوع معين + +90 +00:06:55,260 --> 00:06:59,500 +من الخلايا ووقف النوع هذا ما وقفش وبس لأ هو + +91 +00:06:59,500 --> 00:07:05,080 +بيتكاثر أو الخلايا بتتكاثر بسرعة كبيرة مما أدى + +92 +00:07:05,080 --> 00:07:10,260 +لحدوث كمية كبيرة من الـ Undifferentiated self وأدى + +93 +00:07:10,260 --> 00:07:15,520 +إلى نتاج الـ Acute Leukemia نوع معين من أنواع + +94 +00:07:15,520 --> 00:07:19,220 +اللوكيميا حسب الخلية اللي وقف عندها الـ Maturation + +95 +00:07:23,710 --> 00:07:27,570 +هنا نتخيل الـ blood stream كيف بتتطور فيه + +96 +00:07:27,570 --> 00:07:32,070 +اللوكيميا طبعا أنتوا عارفين أنه في البداية أي + +97 +00:07:32,070 --> 00:07:35,510 +mutation أو أي خلال بداية بيبين في الـ bone marrow + +98 +00:07:35,510 --> 00:07:38,710 +و لسه ما بكون شايفة في الـ peripheral blood + +99 +00:07:38,710 --> 00:07:42,770 +النتائج تبعته، هذا في المراحل الأولى، يعني في + +100 +00:07:42,770 --> 00:07:47,150 +المرحلة الأولىممكن يبقى فيه خلل صاير في البون مارو + +101 +00:07:47,150 --> 00:07:52,270 +لكن ممكن أنا أجي أشوف Stage 1 الـBlood Normal زي + +102 +00:07:52,270 --> 00:07:57,870 +وزي الـNormal الـYPCs الـRBCs البلاتلتز كلياتها + +103 +00:07:57,870 --> 00:08:02,050 +بالوضع الطبيعي لإلهامرحلة التانية اللي هي المرحلة + +104 +00:08:02,050 --> 00:08:06,430 +اللي بتتجاوز الـ bone marrow وبتبدأ تظهر البلاست + +105 +00:08:06,430 --> 00:08:10,510 +بأعداد قليلة في الـ peripheral blood فهذه هي + +106 +00:08:10,510 --> 00:08:14,610 +المرحلة اللي بتبدأ تظهر فيها أعراض اللوكيميا الـ + +107 +00:08:14,610 --> 00:08:20,450 +acute leukemia الآن تبدأ البلاست cells تغزو الـ + +108 +00:08:20,450 --> 00:08:26,500 +bone marrow المرحلة اللي بعدها تبدأأعداد الـ Blast + +109 +00:08:26,500 --> 00:08:31,120 +Cells تزيد وتؤثر بشكل كبير على الخلايا الـ Normal + +110 +00:08:31,120 --> 00:08:35,080 +يعني لو أتينا لاحظنا صار تناقص ملحوظ في أعداد الـ + +111 +00:08:35,080 --> 00:08:38,320 +White Blood Cells الـ Normal صار تناقص في الـ RBC + +112 +00:08:38,320 --> 00:08:41,780 +صار تناقص في الـ Platelets هي المرحلة هذه اللي + +113 +00:08:41,780 --> 00:08:45,940 +بنشخص فيها أن هذه حالة لوكيمياالمرحلة الرابعة اللي + +114 +00:08:45,940 --> 00:08:50,760 +هي أسوأ مرحلة أسوأ مرحلة زي ما انتوا شايفين انه + +115 +00:08:50,760 --> 00:08:55,760 +الـ White BCs مادلش خالص كل اللي موجودة immature + +116 +00:08:55,760 --> 00:09:01,520 +فيه ضايل عندي RBCs بأعداد قليلة وBlatelets بأعداد + +117 +00:09:01,520 --> 00:09:06,260 +قليلة هذه المرحلة سيئة طبعا بعد هيك إيش هيصير + +118 +00:09:06,260 --> 00:09:11,640 +هيغزوا لـ BLAST كل الـ Peripheral Blotمش هلاقي + +119 +00:09:11,640 --> 00:09:18,100 +عندي تقريبًا غير Blast وهذا يؤدي هذه Stage 5A يعني + +120 +00:09:18,100 --> 00:09:21,440 +أن الـ Blast غزت طبعًا الـ Blast غزت هذه خلايا صحي + +121 +00:09:21,440 --> 00:09:25,460 +كتيرة لكن non-functional هيؤدي لإنه تدخل + +122 +00:09:25,460 --> 00:09:29,100 +الميكروبات اللي هي هذه باللون الأخضر ال germ وتغزو + +123 +00:09:29,100 --> 00:09:33,540 +ال blood وتعمل المضاعفات السيئة لللوكيميا، تمام؟ + +124 +00:09:33,540 --> 00:09:36,820 +هيك مراحل تطور اللوكيميا في ال blood stream + +125 +00:09:41,870 --> 00:09:47,750 +طبعاً عشان نتذكر مع بعض قلنا إنه في عندى + +126 +00:09:47,750 --> 00:09:52,970 +hemobiotic stem cell في البونمارو هذه بتعطيني + +127 +00:09:52,970 --> 00:09:58,210 +lymphoid progenitor وبتعطيني myeloid progenitor + +128 +00:09:58,210 --> 00:10:03,750 +صح؟ الـ lymphoid بتكون منها اللي هي الـ B + +129 +00:10:03,750 --> 00:10:08,040 +-lymphocyte والـ T-lymphocyteالـ B-Lymphocyte زي + +130 +00:10:08,040 --> 00:10:11,420 +ما احنا عارفين في مراحل متقدمة بتتحول لـ Plasma + +131 +00:10:11,420 --> 00:10:15,220 +Cell عشان تكون الـ Antibody و بعد هيك الـ T + +132 +00:10:15,220 --> 00:10:18,000 +-Lymphocyte و الـ T-Lymphocyte لها أنواعها + +133 +00:10:18,000 --> 00:10:23,400 +المتعددة هذا اللي هو الفرع اللي كون الـ Lymphoid + +134 +00:10:23,400 --> 00:10:27,720 +طيب الـ AML … عفواً الـ Myeloid الـ Myeloid هينتج + +135 +00:10:27,720 --> 00:10:34,270 +منها اللي هي الـ Granulocyte و هينتج منهاالـ + +136 +00:10:34,270 --> 00:10:40,330 +Monocyte وهينتج منها الـ Platelets وهتنتج منها الـ + +137 +00:10:40,330 --> 00:10:45,770 +RBCs تمام؟ هطلع عندي في النهاية Neutrophil زينوفيل + +138 +00:10:45,770 --> 00:10:50,870 +بيزوفيل هدول الـ Granulocyte بالإضافة للـ Monocyte + +139 +00:10:50,870 --> 00:10:56,030 +بالإضافة للـ Platelets بالإضافة للـ RBCs فأي خلل + +140 +00:10:56,030 --> 00:11:01,430 +في هدول بسمي اللوكيميا Acute Myeloid Leukemia الـ + +141 +00:11:01,430 --> 00:11:06,200 +Myeloid Precursorلو صار خلل في الـ lymphoid بسميها + +142 +00:11:06,200 --> 00:11:11,460 +acute lymphoid leukemia تمام هك؟ طبعا حسب الخلل + +143 +00:11:11,460 --> 00:11:15,140 +بنصنف اللوكيميا زي ما هنشوف لقدام في الشرايح + +144 +00:11:15,140 --> 00:11:20,820 +القادمة لو + +145 +00:11:20,820 --> 00:11:25,340 +أجينا نشوف التوزيع الديمографي لللوكيميا هنلاقي + +146 +00:11:25,340 --> 00:11:31,660 +أكتر نوع بيصير اللي هو الـ AML الـ acute myeloid + +147 +00:11:31,660 --> 00:11:38,560 +leukemiaAcute Myeloid Leukemia بشكل 31% من حالات + +148 +00:11:38,560 --> 00:11:43,940 +اللوكيميا الـ Total بعد هيك بيشي وراها Chronic + +149 +00:11:43,940 --> 00:11:51,400 +Lymphoid Leukemia بتشكل 26% من الحالات بعد هيك + +150 +00:11:51,400 --> 00:12:00,130 +بتيجي عندي الـ CML بتشكل 15% من الحالاتبعدين بتيجي + +151 +00:12:00,130 --> 00:12:06,810 +عند الـ ALL بتشكل 11% من مجموع الحالات بعدين الـ17 + +152 +00:12:06,810 --> 00:12:12,790 +% اللي ضايلين هدال من أنواع لوكيميا متفرقة يعني + +153 +00:12:12,790 --> 00:12:19,130 +كلها بمجملها بتيجي 17% فهي تعتبر قليلة أو نادرة + +154 +00:12:19,130 --> 00:12:25,990 +الحدوث طيب + +155 +00:12:25,990 --> 00:12:32,240 +نيجي للـAcute LeukemiaAcute Leukemia أيش بنشوف + +156 +00:12:32,240 --> 00:12:37,900 +فيها في ال lab في المختبر أول حاجة بالنسبة للـ + +157 +00:12:37,900 --> 00:12:41,940 +Blood Examination طبعا يا بنات يعني الـ Acute + +158 +00:12:41,940 --> 00:12:45,260 +Leukemia بدنياكم تاخدوا قاعدة أنه يعني في + +159 +00:12:45,260 --> 00:12:48,380 +variation يعني حسب ال stage اللي بوصلني فيه المريض + +160 +00:12:48,380 --> 00:12:54,120 +هلاقي مراحل تطور المرض تنعكس على الـCVC لإله ممكن + +161 +00:12:54,120 --> 00:12:57,310 +ألاقي المريض عنده أنيمياممكن إذا كان في المراحل + +162 +00:12:57,310 --> 00:13:01,430 +الأولى ألاقي لسه مش صاير عنده أنيميا، تمام؟ بس إيش + +163 +00:13:01,430 --> 00:13:04,810 +المتوقع إنه ينتج عن الـ Acute Leukemia الأشياء + +164 +00:13:04,810 --> 00:13:10,390 +هذه؟ أنيميا، Thrombocytopenia، Variable Leukocyte + +165 +00:13:10,390 --> 00:13:13,970 +Count يعني مش شرط ألاقي الـ Leukocyte عشانها acute + +166 +00:13:13,970 --> 00:13:17,570 +عالية، لأ ممكن ألاقي فيه variation في الـ + +167 +00:13:17,570 --> 00:13:21,870 +Leukocyte Count ممكن تبقى عالية، غالبا بتكون عالية + +168 +00:13:21,870 --> 00:13:26,630 +لكن ممكن برضه ما تكونش عاليةBlood Morphology لو + +169 +00:13:26,630 --> 00:13:30,530 +جيت أعمل Blood Film أكيد هلاقي Blast Cells وهذا + +170 +00:13:30,530 --> 00:13:33,430 +اللي بيميز الـ Acute Leukemia يعني هاد يخلوها + +171 +00:13:33,430 --> 00:13:39,190 +قاعدة أنه عشان أعتبر الخلية Acute أو أعتبر أن هذه + +172 +00:13:39,190 --> 00:13:44,390 +حالة Acute Leukemia لازم يكون عندي Blast Cells طب + +173 +00:13:44,390 --> 00:13:49,370 +قداش نسبة لـ Blast Cells في البون مرب نحكيالـ Bone + +174 +00:13:49,370 --> 00:13:53,110 +marrow morphology الـ Blast cells عشان أقول إنها + +175 +00:13:53,110 --> 00:13:57,550 +Acute لوكيميا لازم عدد لـ Blast cells يتجاوز الـ + +176 +00:13:57,550 --> 00:14:03,150 +20% فما فوق من عدد الـ White pieces يعني عشان + +177 +00:14:03,150 --> 00:14:08,190 +تُعتبر Acute لوكيميا لازم يكون فيها Blast 20% فما + +178 +00:14:08,190 --> 00:14:12,310 +فوق أقل من هيك لا تُعتبر Acute لوكيميا ممكن تكون + +179 +00:14:12,310 --> 00:14:16,980 +Chronic أو ممكن تكون مشكلة تانيةSubmission of + +180 +00:14:16,980 --> 00:14:20,260 +Normal Hemobiosis يعني لو أنا أجيت في ردد فيلم + +181 +00:14:20,260 --> 00:14:23,880 +«بون مارو» أتفرج عليه إن شاء الله إذا قدرنا ربنا + +182 +00:14:23,880 --> 00:14:27,260 +أه أنتوا شوفته في الـ «هيماتولوجيا» صحيح في أفلام + +183 +00:14:27,260 --> 00:14:32,420 +اللوكيميا هتلاقي الـ «بون مارو» Blast يعني نادر + +184 +00:14:32,420 --> 00:14:37,380 +لما بتلاقي mature cells خلايا mature أو خلايا + +185 +00:14:37,380 --> 00:14:40,320 +صيرلها Normal Maturation أو في الـ Normal + +186 +00:14:40,320 --> 00:14:43,240 +Maturation Stages العادية هتلاقي الـ «بون مارو» + +187 +00:14:43,240 --> 00:14:48,290 +معظمه Blast Cellsبعد هيك بنيجي للفحوصات اللي + +188 +00:14:48,290 --> 00:14:51,670 +بنعملها الـ cytochemical stance حنحكي عنها ونرجعها + +189 +00:14:51,670 --> 00:14:55,610 +الـ immunophenotyping والـ cytogenetics والـ + +190 +00:14:55,610 --> 00:15:02,090 +molecular studies الأخرى الآن + +191 +00:15:02,090 --> 00:15:06,970 +راح نحكي عن ال classification of cells of immature + +192 +00:15:06,970 --> 00:15:09,610 +cells اللي بتتكون في اللوكيميا أو اللي بتصير في + +193 +00:15:09,610 --> 00:15:13,460 +اللوكيمياالـClassification هذا ممكن يكون حسب أكتر + +194 +00:15:13,460 --> 00:15:15,800 +من شغلة ممكن يكون حسب الـMorphology أو + +195 +00:15:15,800 --> 00:15:18,500 +الـCytochemistry أو الـImmunophenotyping أو + +196 +00:15:18,500 --> 00:15:22,500 +الـCytogenetics يعني في أشياء كتير ممكن نعمل + +197 +00:15:22,500 --> 00:15:24,500 +Classification على حسبها وتساعدني في + +198 +00:15:24,500 --> 00:15:27,300 +الـClassification للخلايا الآن نيجي إلى + +199 +00:15:27,300 --> 00:15:32,520 +الـMorphology الآن أول حاجة يعني قدامي Blast Cell + +200 +00:15:32,520 --> 00:15:37,260 +أول حاجة بدي أطلع على حجم الـBlast Size ممكن + +201 +00:15:37,260 --> 00:15:41,620 +يعطيني Indication على نوع الـBlastThe amount of + +202 +00:15:41,620 --> 00:15:45,420 +cytoplasm كمية الـ «cytoplasm» والله مثلا الـ + +203 +00:15:45,420 --> 00:15:49,540 +«cytoplasm» كميته كبيرة معنى الكلام إن هذه الـ + +204 +00:15:49,540 --> 00:15:54,240 +«blast» بادي يصيرلها «maturation» إذا كان لسه الـ + +205 +00:15:54,240 --> 00:15:57,340 +«cytoplasm» كميته ضئيلة جداً لسه هي «early blast» + +206 +00:15:57,340 --> 00:16:02,840 +بتكون «the nuclear chromatin pattern» أحنا عارفين + +207 +00:16:02,840 --> 00:16:06,900 +إن مع الـ «maturation» الـ «nuclear material» + +208 +00:16:06,900 --> 00:16:10,670 +بتصير «coarser»يعني في الـ Early Blast بتكون الـ + +209 +00:16:10,670 --> 00:16:14,330 +chromatin material very fine طيب، هل هي لازالت + +210 +00:16:14,330 --> 00:16:17,990 +fine ولا بلشت تصير more mature؟ هل صار الـ + +211 +00:16:17,990 --> 00:16:22,150 +chromatin material coarse أكتر؟ هل في مثلا الـ + +212 +00:16:22,150 --> 00:16:26,710 +nucleoli طبعاً وجود الـ nucleoli أو اختفاقها، عدم + +213 +00:16:26,710 --> 00:16:29,830 +ظهورها يعني بدل على الـ maturation كل ما كانت + +214 +00:16:29,830 --> 00:16:33,570 +الخلية mature أكتر أو الـ blast mature أكتر هتبدأ + +215 +00:16:33,570 --> 00:16:36,270 +الـ coarse chromatin material تغطي الـ nucleoli + +216 +00:16:36,270 --> 00:16:40,900 +وبطل أشوفهاهل في our rods دايمًا الـ our rods بتدل + +217 +00:16:40,900 --> 00:16:44,520 +على إنه myeloid مش lymphoid مثلًا إنه الخلايا هذه + +218 +00:16:44,520 --> 00:16:48,200 +أصلها من الـ myeloid precursor أشوف our rod برفع + +219 +00:16:48,200 --> 00:16:52,940 +من بالي خالص فكرة الـ lymphoid our rod إيش هي؟ الـ + +220 +00:16:52,940 --> 00:16:57,620 +our rod هو يعني إذا كنتوا فاكرين هو تجمع من الـ + +221 +00:16:57,620 --> 00:17:00,960 +azerofilic granules على شكل الـ rod our rod are + +222 +00:17:00,960 --> 00:17:06,300 +being standingSplinter shape inclusion due to a + +223 +00:17:06,300 --> 00:17:09,980 +rod shape alignment of primary granules found only + +224 +00:17:09,980 --> 00:17:14,160 +in myeloproliferative processes يعني هي عبارة عن + +225 +00:17:14,160 --> 00:17:18,240 +تجمع وارتباط يمكن تلاقيها على شكل عصاية رد صغير من + +226 +00:17:18,240 --> 00:17:21,140 +الـprimary أو الـazolephric granules موجودة في + +227 +00:17:21,140 --> 00:17:27,520 +الـmyeloid precursor عندي هنا صورة myeloblast + +228 +00:17:27,520 --> 00:17:31,900 +موجود فيها أول رد زي ما أنتوا شايفين myeloblast + +229 +00:17:32,240 --> 00:17:38,220 +عبارة عن Large Blast with moderate amount of + +230 +00:17:38,220 --> 00:17:42,860 +cytoplasm فيه cytoplasm كروماتين material fine + +231 +00:17:42,860 --> 00:17:46,600 +بشوف فيها نيوكليولاي زي ما انتوا شايفين هي + +232 +00:17:46,600 --> 00:17:53,800 +نيوكليولاي واضحة تقريبا من 10 إلى 40% من الـ + +233 +00:17:53,800 --> 00:17:57,880 +Myeloid precursor من الـ Myeloblast يعني بلاقي + +234 +00:17:57,880 --> 00:18:02,440 +فيها الأورودزهي الأورود واضحين في الـCytoplasm زي + +235 +00:18:02,440 --> 00:18:06,760 +ما انتوا شايفين هذه الأورود في الـCytoplasm إذن + +236 +00:18:06,760 --> 00:18:11,840 +إذا أنا شوفت أورود بستفني الـLymphoid precursors + +237 +00:18:11,840 --> 00:18:16,440 +نهائيًا Myeloid هي أو Myeloblast هي اللي بشوف فيها + +238 +00:18:16,440 --> 00:18:24,680 +الأورود نيجي + +239 +00:18:24,680 --> 00:18:29,360 +للـLymphoid الـLymphoidالـ Lymphoblast عبارة عن + +240 +00:18:29,360 --> 00:18:34,700 +إلى حد ما بلاست أصغر With scant cytoplasm كمية الـ + +241 +00:18:34,700 --> 00:18:38,780 +cytoplasm قليلة شحيحة جدا Chromatin material إلى + +242 +00:18:38,780 --> 00:18:45,300 +حد ما بيبقى dense النوية مش دائما بتكون كتير واضحة + +243 +00:18:45,300 --> 00:18:49,180 +أو الـ rods مش موجودة خالص أو الـ rods مش موجودة + +244 +00:18:49,180 --> 00:18:53,080 +خالص هذه الـ lymphoblast برضه بعود بذكركم يا بنات + +245 +00:18:53,080 --> 00:18:58,180 +أنه الـ lymphoblast من myeloblastحتى لو كنت أنا + +246 +00:18:58,180 --> 00:19:02,340 +خبيرة جداً لازم أفصل بينهم بالـ «cytochemical + +247 +00:19:02,340 --> 00:19:07,180 +stains» اللي هنذكرها مع بعضنا أدنا اللي هي + +248 +00:19:07,180 --> 00:19:09,660 +الـmyelobruxidase و «السودان البلاك» وهدول اللي + +249 +00:19:09,660 --> 00:19:13,060 +هنرجعهم إن شاء الله رب العالمين مع بعض بمعنى إنه + +250 +00:19:13,060 --> 00:19:17,140 +مهما كنت أنا expert ما بقدر 100% أقول إن هذه + +251 +00:19:17,140 --> 00:19:21,220 +myeloblast أو lymphoblast أنا بتوقع تمام بعد هيك + +252 +00:19:21,220 --> 00:19:24,220 +بأكد بالـ«cytochemical stains» أو + +253 +00:19:24,220 --> 00:19:25,500 +بالـ«immunophenotyping» + +254 +00:19:29,100 --> 00:19:33,780 +هنيجي لتصنيفات اللوكيميا طبعاً احنا عارفين إن + +255 +00:19:33,780 --> 00:19:37,060 +اللوكيميا قد تكون chronic أو acute سواء chronic أو + +256 +00:19:37,060 --> 00:19:41,060 +acute هتكون lymphoid أو myeloid الـ acute-leukemia + +257 +00:19:41,060 --> 00:19:46,100 +تم تصنيفها بناء على دراسات يعني استخدمت الدراسات + +258 +00:19:46,100 --> 00:19:49,720 +هذه الـ morphology مع الـ cytochemical standard تم + +259 +00:19:49,720 --> 00:19:54,620 +تصنيفها إلى lymphoid and myeloid تمام، الـ + +260 +00:19:54,620 --> 00:20:00,280 +lymphoid تم تقسيمها من M0 إلى M7والمفايد تم + +261 +00:20:00,280 --> 00:20:05,520 +تقسيمها من الـ 1 إلى الـ 3 راح نراشع مع بعض كيف + +262 +00:20:05,520 --> 00:20:15,240 +بعمل دا طيب ميجي الـ ALL الـ ALL عادة بتتم تصنيفها + +263 +00:20:15,240 --> 00:20:20,520 +حسب الفئة بـ classification إلى 3 أنواع الـ 1 الـ + +264 +00:20:20,520 --> 00:20:27,140 +2 الـ 3بالـ «Morphology» العادي بدون استخدام أصباغ + +265 +00:20:27,140 --> 00:20:30,960 +تانية بدون استخدام «Cytochemical Stains» يعني + +266 +00:20:30,960 --> 00:20:34,540 +بصبغة الـ «Hematologist Stain» العادية، إيش بشوف؟ + +267 +00:20:34,540 --> 00:20:38,840 +بشوف الألوان الخلايا عبارة عن «Small Blast» + +268 +00:20:38,840 --> 00:20:42,720 +«Homogeneous» أو «Uniform Size» يعني بتحس إن كل + +269 +00:20:42,720 --> 00:20:45,740 +الـ «Blood Film» أو كل الـ «Blast» الموجود عندك في + +270 +00:20:45,740 --> 00:20:48,120 +الـ «Blood Film» أو في الـ «Bone Marrow Film» + +271 +00:20:48,120 --> 00:20:52,570 +هتلاقيها كلها نفس الحجم تقريبا أو متقاربة جداالـ + +272 +00:20:52,570 --> 00:20:56,790 +Cytoplasm قليل Scanty Cytoplasm النوات عتها بتكون + +273 +00:20:56,790 --> 00:21:02,050 +Round Small Enucleolus أحياناً بشوف فيها Small + +274 +00:21:02,050 --> 00:21:08,190 +Enucleolite تمام؟ هذه بتشكل 75% من الـ ALL cases + +275 +00:21:08,190 --> 00:21:12,910 +بتشكل 75% من حالات الـ Acute Lymphoid Leukemia + +276 +00:21:12,910 --> 00:21:20,550 +نيجي لـ L2 L2 بتتميز الخلايا بأنها LargeIrregular + +277 +00:21:20,550 --> 00:21:23,830 +Size يعني بتلاقي أكتر من Size في الـ Blood Film + +278 +00:21:23,830 --> 00:21:28,970 +يعني هذه في الـ L1 كنا نقول تقريبا كلهم نفس الحجم، + +279 +00:21:28,970 --> 00:21:33,630 +هنا لأ هتلاقي خلايا heterogeneous في خلايا كبيرة، + +280 +00:21:33,630 --> 00:21:38,090 +في خلايا صغيرة بالإضافة لأن كمية الـ Cytoplasm + +281 +00:21:38,090 --> 00:21:42,590 +هتلاقيها شوية أكبر الـ Nucleus بتلاقيها برضه + +282 +00:21:42,590 --> 00:21:46,790 +Irregular و الـ Nucleoli برضه ممكن تشوفيها واضحة + +283 +00:21:46,790 --> 00:21:48,590 +تمام؟ + +284 +00:21:52,750 --> 00:21:59,370 +التلاتة التلاتة تتميز بأنها كبيرة لكن uniform صحيح + +285 +00:21:59,370 --> 00:22:03,230 +هي كبيرة لكن بتلاقي الأحجام متقاربة abundance of + +286 +00:22:03,230 --> 00:22:05,950 +cytoplasm الـ cytoplasm تبعها بيبقى كبير برضه + +287 +00:22:05,950 --> 00:22:11,330 +بنلاحظ وجود vacuoles فيها هذه الـ vacuoles عبارة + +288 +00:22:11,330 --> 00:22:17,670 +عن vacuoles موجود فيها fats، lipids وتعطيها هذه + +289 +00:22:17,670 --> 00:22:20,270 +خاصية الصباغة بالـ sudan black زي ما عندنا هنشوف + +290 +00:22:21,240 --> 00:22:26,920 +الـ nucleus بتاعتها round نيوكليولاي واضحة الـ L2 + +291 +00:22:26,920 --> 00:22:35,060 +بتشكل 20% الـ L3 بتشكل تقريباً + +292 +00:22:35,060 --> 00:22:44,080 +5% من الـ total ALL cases طيب + +293 +00:22:44,080 --> 00:22:49,450 +نيجي للـ acute lymphoblastic leukemia L1الـ 1 + +294 +00:22:49,450 --> 00:22:55,070 +ناخدهم واحدة واحدة بالتفصيل الـ 1 is the most + +295 +00:22:55,070 --> 00:22:59,330 +common form found in children and it has the best + +296 +00:22:59,330 --> 00:23:02,330 +prognosis يعني أفضل واحدة من ناحية الـ prognosis + +297 +00:23:02,330 --> 00:23:06,570 +the cell size is small with fine or clumped + +298 +00:23:06,570 --> 00:23:10,250 +homogeneous nuclear chromatin and absent or + +299 +00:23:10,250 --> 00:23:14,890 +indistinct nuclei يعني ممكن أشوف nuclei بس مش كتير + +300 +00:23:14,890 --> 00:23:18,570 +واضحةقالتوا إذا كنتوا فاكرينه قالت لأ تكنت الـ + +301 +00:23:18,570 --> 00:23:25,430 +Nuclear Lie فيهم أوضح طيب الـ Nuclear shape is + +302 +00:23:25,430 --> 00:23:33,480 +regular الخلية النوة بتاعتها يعني بتكون منتظمةممكن + +303 +00:23:33,480 --> 00:23:39,540 +تبقى oval عفوًا ممكن تبقى rounded وفيها إكلفت بسيط + +304 +00:23:39,540 --> 00:23:43,640 +أو indentation يعني هتلاقي فيها نطوق صغير في داخل + +305 +00:23:43,640 --> 00:23:47,560 +جاي هيك داخل لجوا في الـ nucleus الـ cytoplasm + +306 +00:23:47,560 --> 00:23:52,460 +تاعة هيكون slight to moderate بيزوفيليا هتلاقيه + +307 +00:23:52,460 --> 00:23:56,780 +بيزوفيليك وكميته قليلة الـ L2 + +308 +00:24:03,060 --> 00:24:09,280 +زي ما أنتم لاحظين خلايا أول حاجة بنلاحظها مش + +309 +00:24:09,280 --> 00:24:14,180 +متجانسة L2، the most frequent found in adult + +310 +00:24:14,180 --> 00:24:17,840 +بنلاقيها في الـ Adult، مش في الأصغار الـ cell size + +311 +00:24:17,840 --> 00:24:20,700 +is large and heterogeneous with variable in + +312 +00:24:20,700 --> 00:24:23,900 +nuclear chromatin and prominent nuclei بشوف فيها + +313 +00:24:23,900 --> 00:24:29,500 +nuclei أوضح من ألوان الـ nucleus is irregular، إن + +314 +00:24:29,500 --> 00:24:34,070 +واتعتها irregularبلاقي فيها Clift بسيط and + +315 +00:24:34,070 --> 00:24:39,130 +Intended يعني بتلاقي فيها Clift بسيط وداخل لجوه + +316 +00:24:39,130 --> 00:24:43,170 +هيك وعادة هي مش منتظمة بالشكل الـCytoplasm is + +317 +00:24:43,170 --> 00:24:46,690 +variable and often moderate to abundant يعني ممكن + +318 +00:24:46,690 --> 00:24:51,050 +أشوف Cytoplasm فيها متوسط أو كميته كبيرة على خلاف + +319 +00:24:51,050 --> 00:24:56,090 +ألوان اللي بيكون الـCytoplasm فيها قليلالـ + +320 +00:24:56,090 --> 00:24:59,550 +Cytoplasm بيبقى Basophilic إذا الفرق اللي لاحظناه + +321 +00:24:59,550 --> 00:25:03,570 +بين L1 وL2 L1 كانت الخلايا أهم حاجة خلايا صغيرة + +322 +00:25:03,570 --> 00:25:07,610 +متجانسة Cytoplasm تبعها قليل هنا خلايا كبيرة غير + +323 +00:25:07,610 --> 00:25:11,950 +متجانسة وغير منتظمة الـ Cytoplasm لإلها أكتر من + +324 +00:25:11,950 --> 00:25:19,890 +الـ L1 L3 + +325 +00:25:22,390 --> 00:25:27,510 +L3 أقل واحدة، Under واحدة بتشكل بس 5% من مجموع + +326 +00:25:27,510 --> 00:25:32,330 +الحالات الخلايا بتكون فيها كبيرة الـ Nuclear + +327 +00:25:32,330 --> 00:25:37,330 +Chromatin Material هنلاقي … هنلاقي Homogeneous الـ + +328 +00:25:37,330 --> 00:25:41,550 +Nucleoli بتكون فيها واضحة طبعاً إنها بتاعتها + +329 +00:25:41,550 --> 00:25:46,330 +Large، Oval أو Rounded الـ Cytoplasm بلاقي كميته + +330 +00:25:46,330 --> 00:25:49,990 +متوسطة إلى كثيرة بلاقي فيه الـ Vacuoles الواضحة + +331 +00:25:49,990 --> 00:25:54,380 +هذه طبعاً الـ Vacuoles هذهعادةً بتدلل على إنها هذه + +332 +00:25:54,380 --> 00:25:59,740 +التلاتة لأنها هي Fat Vacuoles لما هاجي أعمل صباغة + +333 +00:25:59,740 --> 00:26:03,840 +بالفيلم العادي بتدوب الفات لأن أنا بعمل Fixation + +334 +00:26:03,840 --> 00:26:07,360 +بالإيثانال أو بالميثانال لما بعمل Fixation هيدوّب + +335 +00:26:07,360 --> 00:26:12,680 +الكحول فهيترك مكانه فجوات غير مصبوغة ليش؟ لأنه + +336 +00:26:12,680 --> 00:26:16,520 +فقدت هذه الأماكن أو المحتوى تبعها ذهب وراه مع + +337 +00:26:16,520 --> 00:26:19,620 +الكحول خلال الـFixation علشان أكي بشوف الـVacuoles + +338 +00:26:19,620 --> 00:26:22,980 +هذه كان مفروض فيها فاتلكن هي الآن بيانات فارقة + +339 +00:26:22,980 --> 00:26:28,240 +نيجي + +340 +00:26:28,240 --> 00:26:34,160 +لبعض المعلومات العامة عن الـ ALL عادة هي بتصيب الـ + +341 +00:26:34,160 --> 00:26:38,440 +Children من سنتين إلى خمس سنوات وطبعاً قد تصيب الـ + +342 +00:26:38,440 --> 00:26:43,620 +Adult الـ Clinical Finding لها يعني أول حاجة الـ + +343 +00:26:43,620 --> 00:26:51,540 +Symptoms العامة زي بالر، شحوبزي مثلًا Wet loss، + +344 +00:26:51,540 --> 00:26:55,620 +fever، Irritability، Anorexia Infection، bleeding، + +345 +00:26:55,620 --> 00:26:59,980 +and wound pain طبعًا بان سايتوبينيا بان سايتوبينيا + +346 +00:26:59,980 --> 00:27:04,400 +لأنه فيه ineffective hemobiasis فهتلاقي أنه الـ + +347 +00:27:04,400 --> 00:27:06,880 +Blatelets هتنزل الـ white bases اللي هي الـ + +348 +00:27:06,880 --> 00:27:09,300 +functional ال mature white bases هيصير فيها + +349 +00:27:09,300 --> 00:27:13,680 +deficiency اللي هي مسؤولة عن المقاومة ضد ال + +350 +00:27:13,680 --> 00:27:16,980 +infection فعشان هيصير infectionحيصير الـ bleeding + +351 +00:27:16,980 --> 00:27:21,200 +نتيجة الـ pancytopemia حيصير شخوب نتيجة أن الـ + +352 +00:27:21,200 --> 00:27:25,000 +RBCs ما بتنتج كويس فحيصير أنيميا Bone pain طبعاً + +353 +00:27:25,000 --> 00:27:28,360 +نتيجة الـ stimulation بتاع الـ bone marrow وزيادة + +354 +00:27:28,360 --> 00:27:32,280 +التصنيع للـ abnormal cells عادة الـ one بتصير عند + +355 +00:27:32,280 --> 00:27:35,100 +الأطفال الـ two عند الـ adult الـ ثلاثة تسمى + +356 +00:27:46,390 --> 00:27:51,650 +فبنلاقي المرضى اللي ما بين سنة إلى تلتاشر سنة هدول + +357 +00:27:51,650 --> 00:27:57,890 +أفضل أفضل Prognosis تمام؟ اللي أقل من سنة وأكتر من + +358 +00:27:57,890 --> 00:28:02,890 +تلتاش هدول ال Prognosis اللي لهم بور سيء يعني ممكن + +359 +00:28:02,890 --> 00:28:09,390 +من سنة إلى تلتاش يتعافوا من اللوكينيا الـ ALL طيب + +360 +00:28:09,390 --> 00:28:12,670 +نيشي للـ White BCs Count طبعا الـ White BCs Count + +361 +00:28:13,200 --> 00:28:18,620 +كل مزاد بدل على أنه المرض في مراحل متقدمة أكتر + +362 +00:28:18,620 --> 00:28:24,460 +والحالة أنشط إذا كان الـ YPCs count أقل من 10 ألاف + +363 +00:28:24,460 --> 00:28:29,620 +عند الـ diagnosis الـ prognosis بيكون أفضل إذا كان + +364 +00:28:29,620 --> 00:28:34,380 +فوق العشرين ألف غالباً الـ prognosis poor تمام + +365 +00:28:34,380 --> 00:28:41,100 +الشغل التالتة المهمة برضه اللي هي الـ + +366 +00:28:42,630 --> 00:28:46,330 +الخلية اللي موجودة أو الـ Predominant Cell إذا + +367 +00:28:46,330 --> 00:28:51,390 +كانت تيسل تيسل عادة بتكون أكثر شيوعا عند المال + +368 +00:28:51,390 --> 00:28:56,970 +التيسل بورر الـ Prognosis بورر الـ Prognosis يعني + +369 +00:28:56,970 --> 00:29:00,410 +الـ Prognosis بتاعك ليش؟ لأن تيسل يبقى وظائفها + +370 +00:29:00,410 --> 00:29:06,950 +أكتر أصلا من الـ B cell في الجسم طيب الـ B cell + +371 +00:29:08,270 --> 00:29:12,910 +عادة يعني ممكن يصير معدل شفاء 70% من الناس اللي + +372 +00:29:12,910 --> 00:29:17,630 +عندهم ALL والـ diagnosis كان بـ cell أو المشكلة + +373 +00:29:17,630 --> 00:29:22,410 +كانت جاية من الـ B cell يعني الـ B cell الـ + +374 +00:29:22,410 --> 00:29:23,550 +prognosis تبعها أفضل + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4.srt new file mode 100644 index 0000000000000000000000000000000000000000..16f0fe791d2e6cf10ef2a4c2c3f39951fbaf8308 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4.srt @@ -0,0 +1,2247 @@ +1 +00:00:01,690 --> 00:00:06,950 +اعوذ بالله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى في هذا الفصل في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما تكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في الـ outlines حكينا إنه هذا المساق يتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعًا أنتم تعرفون أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبًا تُقسم إلى Three categories التي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها، اللوكيميا وملحقاتها، + +8 +00:00:39,390 --> 00:00:43,470 +وCoagulation disorders فستكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +الثلاثة التي سنُتناولها في هذا الفصل، سنأخذ موجزًا + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخصًا عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة، وبعد ذلك ستكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع سنكملها على شكل case studies لأن + +13 +00:01:06,360 --> 00:01:10,500 +يهمني اليوم ليس أن أحفظ ما هو تعريف الأنيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +ما هو تعريفها أو ما هو الـ pathophysiology التابع لها أو ما هو + +15 +00:01:12,540 --> 00:01:17,040 +هذا الكلام، لا، يهمني عندما أرى result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط هذه النتائج مع بعض وأستنتج ما هي + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية التي قد تكون مصاحبة لهذا الـ result + +18 +00:01:25,790 --> 00:01:29,330 +ما الذي يلزمنا أن نطلب فحوصات فيما بعد أو ما الذي يلزمنا أن ندور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات حتى نتأكد من الـresults المعينة هذا + +20 +00:01:32,370 --> 00:01:36,290 +الكلام بإذن الله كله سنناقشه مع بعض شيئًا فشيئًا + +21 +00:01:36,290 --> 00:01:40,670 +أول شيء سنشرحه ثالثًا + +22 +00:01:40,670 --> 00:01:46,010 +الـ normocytic normochromic anemia خلايا تتميز بأن + +23 +00:01:46,010 --> 00:01:49,970 +حجمها طبيعي والـ hemoglobin content لها طبيعي لكن + +24 +00:01:49,970 --> 00:01:55,630 +فينا حالة أنيمية فينا نقص في + +25 +00:01:55,760 --> 00:01:59,380 +Normochromic Anemia زي ما قلنا الـ Size and + +26 +00:01:59,380 --> 00:02:02,480 +Hemoglobin content is normal but the number of + +27 +00:02:02,480 --> 00:02:06,200 +RBCs decreased يعني الخلل يكون في عدد الـ RBCs ما + +28 +00:02:06,200 --> 00:02:10,760 +تأثر أي شيء في الـ erythrocyte نفسها في شكلها في + +29 +00:02:10,760 --> 00:02:14,960 +حجمها في كمية الـ Hemoglobin لكن الذي يتغير عدد + +30 +00:02:14,960 --> 00:02:20,300 +الـ RBCs طبعًا هذه لها أسباب، أسبابها الـ aplastic + +31 +00:02:20,300 --> 00:02:24,160 +أنيميا due to bone marrow failure يعني فينا مشكلة + +32 +00:02:24,160 --> 00:02:28,090 +في الـ bone marrow، بلاد لوس أنيميا، في عندي أنيميا + +33 +00:02:28,090 --> 00:02:32,450 +سببها فقد كميات من الدم، hemolytic anemia + +34 +00:02:32,450 --> 00:02:36,390 +للابلاستيك + +35 +00:02:36,390 --> 00:02:40,890 +أنيميا، المشكلة في الـ bone marrow، condition of blood + +36 +00:02:40,890 --> 00:02:44,910 +banned cytopenia caused by bone marrow failure + +37 +00:02:44,910 --> 00:02:48,510 +يعني يبقى في عندنا في الـ bone marrow، وبالتالي + +38 +00:02:48,510 --> 00:02:52,590 +تجد كل الـ Parameters التابعة للـ CBC Low من الـ + +39 +00:02:52,590 --> 00:02:56,250 +WBCs من الـ RBCs من الـ Platelets كله تجدهم + +40 +00:02:56,250 --> 00:03:00,750 +منخفضة Decreased production of all cell lines and + +41 +00:03:00,750 --> 00:03:05,510 +replacement of marrow with fat تجد أن الـ bone + +42 +00:03:05,510 --> 00:03:09,310 +marrow صار replacement لإياه بالـ Yellow marrow + +43 +00:03:09,310 --> 00:03:14,950 +بالدهن، طبعًا هذا يكون سببه due to damaged stem + +44 +00:03:14,950 --> 00:03:18,630 +cells، damage bone marrow environment or suppression + +45 +00:03:18,630 --> 00:03:24,650 +يصير خلل في الـ stem cells، فبالتالي ينشأ عنه + +46 +00:03:24,650 --> 00:03:29,430 +suppression للـ bone marrow في هذه الحالة لا يصير + +47 +00:03:29,430 --> 00:03:34,250 +تعويض، يعني لا يصير extra medullary hematopoiesis + +48 +00:03:34,250 --> 00:03:37,770 +أحنا قلنا إن في بعض الأحيان عندما يصير تكسر في ال + +49 +00:03:37,770 --> 00:03:43,010 +RBCs يصير extra medullary hematopoiesis حتى يعوّض + +50 +00:03:43,010 --> 00:03:47,610 +الخلل الذي صار أو النقص الذي صار، لكن في هذه الحالة + +51 +00:03:47,610 --> 00:03:50,850 +لا يصير، فبالتالي يظل الـ hemoglobin و ال + +52 +00:03:50,850 --> 00:03:56,750 +parameters الأخرى كلها منخفضة، ما هي أنواع ال + +53 +00:03:56,750 --> 00:04:02,330 +aplastic anemia؟ الـ aplastic anemia نوعان أو ثلاثة + +54 +00:04:02,330 --> 00:04:06,050 +أنواع رئيسية، الأكثر شيوعًا النوعان اللذان هما ال + +55 +00:04:06,050 --> 00:04:09,810 +primary و الـ secondary، الـ primary يبقى خلل أساسًا + +56 +00:04:09,810 --> 00:04:13,250 +في الـ hormonal، يبقى سببه idiopathic، الـ secondary + +57 +00:04:13,820 --> 00:04:18,660 +عادةً تكون acquired، تأتي نتيجة تعرض الـ patient + +58 +00:04:18,660 --> 00:04:23,900 +لـ chemicals، لبعض الأدوية، لـ infections، لـ radiation، طبعًا + +59 +00:04:23,900 --> 00:04:30,120 +هذه تشكل تقريبًا 50% وهذه تشكل 50%، في نسبة بسيطة + +60 +00:04:30,120 --> 00:04:34,580 +يعني ممكن يكون سببها congenital التي هي فانكانس + +61 +00:04:34,580 --> 00:04:39,300 +أنيميا، هذه تجد أبلاجيا، نقص في كل الـ parameters + +62 +00:04:39,300 --> 00:04:43,200 +يعني نفس الـ picture التابعة للأبلاستيك أنيميا تكون + +63 +00:04:43,200 --> 00:04:48,820 +مصاحبة بـ dwarfism وتكون معها أيضًا skeletal + +64 +00:04:48,820 --> 00:04:52,940 +abnormalities، شوية mental retardation، abnormal + +65 +00:04:52,940 --> 00:04:57,400 +skin pigmentation، يعني تجد فيه تلون في الـ skin + +66 +00:04:57,400 --> 00:05:02,880 +بالإضافة لأقزام، قصر في القامة، أيضًا تجد تشوّه في + +67 +00:05:02,880 --> 00:05:05,860 +الـ skeletal bone + +68 +00:05:10,870 --> 00:05:14,270 +diagnosis of aplastic anemia أول شيء قلنا نحن + +69 +00:05:14,270 --> 00:05:18,330 +سميناها normocytic-normochromic فستجد أن الـ MCV و + +70 +00:05:18,330 --> 00:05:24,030 +الـ MCH و الـ MCHC normal، الـ reticulocyte low، لماذا + +71 +00:05:24,030 --> 00:05:27,850 +low؟ لأنه أساسًا لا يوجد تنبيه للـ bone marrow أنه يصنع + +72 +00:05:27,850 --> 00:05:31,490 +خلايا، فبالتالي تجد فيه كسل في الـ bone marrow، فنجد + +73 +00:05:31,490 --> 00:05:35,170 +لا تجد، يعني فبالتالي لن نجد reticulocyte + +74 +00:05:35,170 --> 00:05:39,530 +normal، سنجدها قليلة، سنجد نقصًا في الـ hemoglobin + +75 +00:05:39,950 --> 00:05:44,470 +زي ما قلنا band-cytopenia، لن نجد أي abnormal + +76 +00:05:44,470 --> 00:05:47,150 +cells، يعني كل الخلايا تجدها normal، لا تجد + +77 +00:05:47,150 --> 00:05:49,770 +abnormality في الـ size ولا تجد abnormality في + +78 +00:05:49,770 --> 00:05:55,150 +الشكل، hypoplegia of bone marrow، يعني تفبيط أو قلة + +79 +00:05:55,150 --> 00:05:58,610 +في نشاط الـ bone marrow، بقى الـ parameters الأخرى + +80 +00:05:58,610 --> 00:06:03,410 +مثل الـ serum iron، الـ vitamin B12، الفولات تجدهم + +81 +00:06:03,410 --> 00:06:06,430 +normal، ستجدهم طبيعيين. + +82 +00:06:13,210 --> 00:06:16,370 +نأتي إلى الـ Hemolytic Anemia، النوع الثاني، إذا + +83 +00:06:16,370 --> 00:06:19,390 +النوع الأول حكينا عنه أبلاستيك أنيميا، النوع الثاني + +84 +00:06:19,390 --> 00:06:24,410 +هو Hemolytic Anemia، الـ Hemolytic Anemia يكون + +85 +00:06:24,410 --> 00:06:30,310 +بسبب زيادة في تكسير الـ premature red cells، قد + +86 +00:06:30,310 --> 00:06:35,170 +تكون compensated أو uncompensated، يعني ممكن الـ bone + +87 +00:06:35,170 --> 00:06:39,450 +marrow يقدر يتعامل معها وممكن لا يقدر يتعامل معاها + +88 +00:06:39,450 --> 00:06:44,130 +حسب الـ rate of hemolysis، طبعًا الـ Hemolytic Anemia + +89 +00:06:44,130 --> 00:06:47,870 +تؤدي إلى ماذا؟ لـ Hyperplasia، ما في عندنا مشكلة في الـ + +90 +00:06:47,870 --> 00:06:52,390 +Bone marrow وهذا ينتج عنه أن الـ Erythroid + +91 +00:06:52,390 --> 00:06:55,910 +precursors تصير تنشط، فنجد الـ Myeloid + +92 +00:06:55,910 --> 00:06:59,490 +Erythroid Ratio انخفضت لأن الـ Erythroid تزيد + +93 +00:06:59,490 --> 00:07:04,210 +Bone marrow، Red Cells Production increase 6 to 8 + +94 +00:07:04,210 --> 00:07:07,990 +times، يعني تزيد من 6 إلى 8 مرات الوضع الطبيعي + +95 +00:07:07,990 --> 00:07:12,370 +أيضًا الـ reticulocyte ستجدها مرتفعة marked + +96 +00:07:12,370 --> 00:07:16,770 +reticulocytosis، ونرى أيضًا inucleated RBCs في الـ + +97 +00:07:16,770 --> 00:07:24,170 +peripheral blood الآن + +98 +00:07:24,170 --> 00:07:28,130 +بالنسبة لتكسير الخلايا في الـ hemolytic anemia قد + +99 +00:07:28,130 --> 00:07:31,970 +تكون بسبب intravascular hemolysis يعني في داخل ال + +100 +00:07:31,970 --> 00:07:34,770 +blood vessels في الـ circulation أو يكون ال + +101 +00:07:34,770 --> 00:07:38,190 +hemolysis extravascular في الـ reticuloendothelial + +102 +00:07:38,190 --> 00:07:38,850 +system + +103 +00:07:42,650 --> 00:07:46,850 +نأتي إلى النوع الأول الذي هو الـ Extravascular + +104 +00:07:46,850 --> 00:07:51,950 +Hemolysis، الـ Extravascular Hemolysis سنلاحظ فيه + +105 +00:07:51,950 --> 00:07:56,530 +أنه يسير بنفس الـ pathway الطبيعي الذي يصير فيه + +106 +00:07:56,530 --> 00:08:00,410 +تكسير للـ RBCs عندما تصير لها aging لكن على وتيرة + +107 +00:08:00,410 --> 00:08:03,950 +أسرع، يعني نحن نعرف أن الـ RBCs عندما تصير لها + +108 +00:08:03,950 --> 00:08:12,040 +aging طبعًا بالإضافة لـ abnormal RBCs ستذهب إلى الـ + +109 +00:08:12,040 --> 00:08:15,600 +reticuloendothelial system، هناك الـ macrophages + +110 +00:08:15,600 --> 00:08:18,740 +ستقوم بإزالتها، طبعًا الـ reticuloendothelial system + +111 +00:08:18,740 --> 00:08:23,100 +نعرفها، الطحال، الكبد، العقد الليمفاوية، هناك سيصير تكسير لل + +112 +00:08:23,100 --> 00:08:27,860 +RBCs، الآن عندما يصير للـ RBCs تكسير سيصير طبعًا + +113 +00:08:27,860 --> 00:08:33,680 +بالنسبة للهيموجلوبين سيصير release للهيم والجلوبين + +114 +00:08:34,150 --> 00:08:38,690 +الجلوبين سيذهب ويكوّن آخر أمينو أسيد، طبعًا الأمينو + +115 +00:08:38,690 --> 00:08:43,110 +أسيد ستُستخدم لـ protein synthesis، يبقى عندنا الهيم + +116 +00:08:43,110 --> 00:08:46,250 +الهيم تتكون من iron، سيصير له reabsorption حتى + +117 +00:08:46,250 --> 00:08:50,810 +يُستخدم مرة أخرى، وبعد ذلك الهيم، الهيم طبعًا عفوا + +118 +00:08:50,810 --> 00:08:55,410 +البروتوبرفيرين، البروتوبرفيرين سيصير له تكسير و + +119 +00:08:55,410 --> 00:08:59,450 +سيتحول لـ unconjugated bilirubin، طبعًا ال + +120 +00:08:59,450 --> 00:09:05,310 +unconjugated bilirubin هذا يعني يكون موجود الذي + +121 +00:09:05,310 --> 00:09:09,010 +بالـ reticuloendothelial system بشكل عام، بده ينتقل + +122 +00:09:09,010 --> 00:09:12,810 +إلى الـ liver، لكي ينتقل بالـ liver هو water insoluble + +123 +00:09:12,810 --> 00:09:17,410 +فبالتالي يرتبط بالألبومين، يروح هناك، يدخل الـ liver + +124 +00:09:17,410 --> 00:09:21,650 +فيترك الألبومين، طبعًا الألبومين كان ناقلًا، لكن عندما + +125 +00:09:21,650 --> 00:09:27,200 +يدخل إلى الـ liver يصير له esterification بإضافة two + +126 +00:09:27,200 --> 00:09:31,000 +glucuronic acid فبتحول ل conjugated bilirubin + +127 +00:09:31,000 --> 00:09:35,560 +فالconjugated bilirubin هينزل على ال intestine من + +128 +00:09:35,560 --> 00:09:39,840 +ال liver عبر ال bile duct لل intestine طبعا هذا + +129 +00:09:39,840 --> 00:09:42,740 +جزء من انه هيصير له reabsorption عن طريق ال + +130 +00:09:42,740 --> 00:09:47,760 +intestine ويتحول لـ urobilinogen و urobilin + +131 +00:09:47,760 --> 00:09:50,460 +طبعاً هيعود بعد نسير الـ absorption يمشي في الـ + +132 +00:09:50,460 --> 00:09:53,220 +blood وبعدين يروح لل urine وينزل على شكل + +133 +00:09:53,220 --> 00:09:57,780 +urobilinogen هذه هي ال pathway بتاعة التكسير + +134 +00:09:57,780 --> 00:10:02,060 +الطبيعي اللي بتصير في الجسم يعني هذه لما بيصير + +135 +00:10:02,060 --> 00:10:05,680 +aging للخلايا هيك بتتأثر في الـ Extravascular + +136 +00:10:05,680 --> 00:10:10,360 +Hemolysis هذا اللي بيصير بس بوتيرة عالية يعني مش + +137 +00:10:10,360 --> 00:10:16,420 +بالشكل الطبيعي اللي بيصير زيادة الـ RBCs breakdown + +138 +00:10:16,420 --> 00:10:20,660 +طبعاً الـ bilirubin هيرتفع ليش؟ لأنه زاد التكسير + +139 +00:10:20,660 --> 00:10:25,500 +فزاد التكسير البروتوبرفيرين تحوله لـ bilirubin + +140 +00:10:25,500 --> 00:10:29,480 +وبالتالي هيبلش الـ bilirubin يرتفع في stool + +141 +00:10:29,480 --> 00:10:32,900 +urobilinogen و blood urobilinogen و urine + +142 +00:10:32,900 --> 00:10:35,580 +urobilinogen هدول نوادج الـ bilirubin كلها + +143 +00:10:35,580 --> 00:10:41,440 +هنلاقيها انها ارتفعت هذا إذن وان في الـ + +144 +00:10:41,440 --> 00:10:42,940 +Extravascular Hemolysis + +145 +00:10:46,970 --> 00:10:51,250 +الـ Intravascular Hemolysis هنا بيصير التكسير في + +146 +00:10:51,250 --> 00:10:54,470 +داخل الـ blood vessels بيصير في داخل الـ blood + +147 +00:10:54,470 --> 00:10:59,770 +vessels والهيموجلوبين هذا عادة عادة ممكن يصير + +148 +00:10:59,770 --> 00:11:05,670 +نتيجة complement activation يعني ممكن يكون نتيجة + +149 +00:11:05,670 --> 00:11:12,230 +immune hemolysis وتحفيز للـ complement فما يعني ما + +150 +00:11:12,230 --> 00:11:15,010 +بيروح الـ reticuloendothelial system بتكسر في داخل + +151 +00:11:15,010 --> 00:11:19,300 +الـ circulation هذا بنتج عنه وجود إكسرة الخلية + +152 +00:11:19,300 --> 00:11:21,700 +هيطلع الـ Hemoglobin منها الأصل إن الـ Hemoglobin + +153 +00:11:21,700 --> 00:11:24,680 +ما بيكون free في ال blood هنا حيصير في عندنا free + +154 +00:11:24,680 --> 00:11:29,280 +Hemoglobin طبعا الـ free Hemoglobin بده ينتقل للـ + +155 +00:11:29,280 --> 00:11:33,560 +liver كيف بينتقل عن طريق الـ haptoglobin اللي هو + +156 +00:11:33,560 --> 00:11:38,120 +البروتين ال carrier للـ Hemoglobin الـ haptoglobin + +157 +00:11:38,120 --> 00:11:42,580 +هنا هتنقص كميتو لأنه هيصير saturated أو منشغل و + +158 +00:11:42,580 --> 00:11:47,650 +مرتبط بالـ Hemoglobin طيب فى كمية من الـ Hemoglobin + +159 +00:11:47,650 --> 00:11:51,490 +برضه هتظل Free هيصيرلها filtration عبر الكلى + +160 +00:11:51,490 --> 00:11:56,410 +Aglomeruli الآن لو كان ال rate للـ Hemolysis كتير + +161 +00:11:56,410 --> 00:11:59,490 +كبير وما .. يعني ماقدرش يعمل Reabsorption للـ + +162 +00:11:59,490 --> 00:12:02,330 +Hemoglobin اللى بينزل هيبدأ يطلع عند Free + +163 +00:12:02,330 --> 00:12:06,370 +Hemoglobin ينزل في ال urine هناك في ال bladder + +164 +00:12:06,370 --> 00:12:12,230 +هيوصل لـ bladder طبعا وهيبدأ شكمية من الـ + +165 +00:12:12,230 --> 00:12:16,690 +Hemosiderin تترسب أو تتكون في الـ urine وألاخظها + +166 +00:12:16,690 --> 00:12:20,590 +أو ألاقيها بشكل واضح، إذن هنا في الـ Intravascular + +167 +00:12:20,590 --> 00:12:25,050 +Hemolysis بتميز بإنه فيه Free Hemoglobin ونشأ عنه + +168 +00:12:25,050 --> 00:12:29,130 +انخفاض haptoglobin، بعدين في الـ urine بلاقي Hemosiderin + +169 +00:12:29,130 --> 00:12:34,170 +Hemoglobinuria + +170 +00:12:34,170 --> 00:12:39,680 +الـ Lab Features، وجود Hemoglobin في الـ urine أو + +171 +00:12:39,680 --> 00:12:42,260 +Hemoglobinemia يعني وجود Hemoglobin في blood أو + +172 +00:12:42,260 --> 00:12:45,760 +Hemoglobinuria وفي ال urine Hemosiderinuria وجود + +173 +00:12:45,760 --> 00:12:49,380 +Hemosiderin في ال urine Reduced or absent serum + +174 +00:12:49,380 --> 00:12:52,880 +haptoglobin لأنه هتلاقي ارتبط بال Hemoglobin عشان + +175 +00:12:52,880 --> 00:13:00,080 +يودي لل metabolism نيجي + +176 +00:13:00,080 --> 00:13:04,040 +لأنواع ال Hemolytic Anemia بداية ال Hereditary + +177 +00:13:04,040 --> 00:13:10,000 +Hemolytic Anemia طبعا هنا هذه عادة بتكون congenital + +178 +00:13:10,000 --> 00:13:15,120 +ممكن تبين بداية عند الولادة أو ممكن خلال مراحل + +179 +00:13:15,120 --> 00:13:19,700 +الحياة في بعضها بيضل silent يعني مافيش عليه مافيش + +180 +00:13:19,700 --> 00:13:24,760 +ال patient عليه أي أعراض لغاية ما يتعرض لمؤثر يبين + +181 +00:13:24,760 --> 00:13:32,440 +هذه المشكلة زي الـ G6PD ممكن طيب هذه إيش أسبابها + +182 +00:13:32,440 --> 00:13:37,700 +أسبابها خلال في الـ Red Cell قد يكون السبب هذا + +183 +00:13:37,700 --> 00:13:44,600 +نتيجة Membrane defect أو خلل في الـ Metabolism طيب + +184 +00:13:44,600 --> 00:13:49,520 +نيجي أول حاجة لمشاكل بالـ membrane defect مشاكل + +185 +00:13:49,520 --> 00:13:53,260 +الـ membrane defect قد تكون يعني من أمثلتها + +186 +00:13:53,260 --> 00:13:56,120 +Spherocytosis وElliptocytosis اللي بتنشأ عنها + +187 +00:13:56,120 --> 00:13:59,800 +أشكال abnormal للخلايا والأشكال هذه هيصير لها أكيد + +188 +00:13:59,800 --> 00:14:05,570 +تكسيرهنا مثلا نجي لـ Spherocytosis Spherocytosis + +189 +00:14:05,570 --> 00:14:09,950 +هنا بيصير خلل في ال spectrin و ankyrin دول + +190 +00:14:09,950 --> 00:14:11,630 +الاثنين المسؤولين عن + +191 +00:14:14,560 --> 00:14:17,640 +الـ Flexibility بتاعة الـ Erythrocyte يعني انه الـ + +192 +00:14:17,640 --> 00:14:21,340 +biconcave shape تبعها مسؤولين عنه زي الـ rubber زي + +193 +00:14:21,340 --> 00:14:24,460 +المغاطة بيبقوا في الخلية داخل الخلية خيوط من + +194 +00:14:24,460 --> 00:14:27,500 +البروتين مسؤولين عن شكل الـ biconcave بتاع الخلية + +195 +00:14:27,500 --> 00:14:31,180 +فإذا صار فقد فيهم أو نقص فيهم هتبدأ الخلية تاخد + +196 +00:14:31,180 --> 00:14:34,740 +الـ Spherocyte shape أضف إلى بعض الحالات اللي بيبقى فيها + +197 +00:14:34,740 --> 00:14:39,080 +خلل بال permeability بتاعة الممبرين فبالتالي بتزود + +198 +00:14:39,080 --> 00:14:44,840 +تدخيل الـ Sodium ions لداخل الخلية وبالتالي بتبعها + +199 +00:14:44,840 --> 00:14:49,080 +الميّه وفي بعض الحالات ممكن تكون نتيجة Hemolytic + +200 +00:14:49,080 --> 00:14:54,920 +Anemia زي في حالات الـ Autoimmune Hemolytic Anemia + +201 +00:14:54,920 --> 00:14:59,200 +المرحلة يعني لما بيصير complement fixation هتبدأ + +202 +00:14:59,200 --> 00:15:02,760 +الخلية يصيرلها perforation لما بيصير perforation + +203 +00:15:02,760 --> 00:15:05,460 +الخلية هتبلش ال fluids تدخل فيها في كمية كبيرة + +204 +00:15:05,460 --> 00:15:09,490 +فهتصير Spherocyte وبعد هيك هيصير لها rupture هنا + +205 +00:15:09,490 --> 00:15:13,090 +بيبين عندنا لما بيصير جزء يعني لصلة جزء من الـ + +206 +00:15:13,090 --> 00:15:17,770 +membrane كيف ممكن خلية تتحول إلى Spherocyte ال lab + +207 +00:15:17,770 --> 00:15:21,510 +finding طبعا الانيميا بتكون مختلفة يعني مش كل + +208 +00:15:21,510 --> 00:15:24,590 +الحالات على نفس ال degree من الانيميا حلاق + +209 +00:15:24,590 --> 00:15:30,550 +Spherocytes في السمير هتلاقي ال MCHC مرتفع فلقيت يا + +210 +00:15:30,550 --> 00:15:36,380 +بنات اتطلعوا معايا الخلية هذه هي Spherocyte الخلية + +211 +00:15:36,380 --> 00:15:41,900 +هنا أصار يعني أصارت الخلية منتفخة واختفى فيها الـ + +212 +00:15:41,900 --> 00:15:45,680 +Biconcave shape هذه الخلايا الـ Spherocytes يعني هي + +213 +00:15:45,680 --> 00:15:50,740 +اللى بنربطها دايما بارتفاع الـ MCHC وارتفاع الـ + +214 +00:15:50,740 --> 00:15:55,640 +MCH الـ MCHC والـ MCH ارتفاعهم لحاله لا يعني شيء + +215 +00:15:55,640 --> 00:15:59,340 +لكن عادة هو مرتبط بالـ Spherocytes لأنه فلاقى أن + +216 +00:15:59,340 --> 00:16:02,400 +الـ Cell Membrane تاع الخلية صغر شوية فبالتالي + +217 +00:16:02,400 --> 00:16:06,540 +صارت نسبة الـ Hemoglobin فيها مرتفعة الـ MCHC + +218 +00:16:06,540 --> 00:16:10,800 +فيها مرتفع يعني a high MCHC Increased + +219 +00:16:10,800 --> 00:16:13,860 +Osmotic Fragility Test وهذا طبعا الفحص إذا كنتوا + +220 +00:16:13,860 --> 00:16:18,000 +فاكرين اللي بيميز الـ Spherocytosis فحص الـ + +221 +00:16:18,000 --> 00:16:19,080 +Osmotic Fragility + +222 +00:16:21,790 --> 00:16:26,010 +نأتي للـ Elliptocytosis أو الـ Elliptocytes بتكون + +223 +00:16:26,010 --> 00:16:30,890 +الخلية شكلها رفيعة زي ما أنتوا شايفين هنا + +224 +00:16:30,890 --> 00:16:38,130 +Elliptocyte شايفين كيف شكلها هنا هذا بيكون سببه أنه + +225 +00:16:38,130 --> 00:16:41,430 +أصار polarization للكلسترال أو للهيموجلوبيين عند + +226 +00:16:41,430 --> 00:16:47,570 +أطراف الخلية فأخدت هذا الشكل هنلاقي تقريبا 25% أو + +227 +00:16:47,570 --> 00:16:52,310 +أكثر of Elliptocytes عادة بتكون asymptomatic ما بدون + +228 +00:16:52,310 --> 00:16:58,510 +أعراض يعني ممكن تنشأ عنا mild anemia الـ + +229 +00:16:58,510 --> 00:17:01,790 +Stomatocytosis هي شكل الخلية زي ما أنتوا فاكرين + +230 +00:17:01,790 --> 00:17:06,150 +فيها slit في الوسط زي فتحة زي شق بسيط هنا بيبقى + +231 +00:17:06,150 --> 00:17:11,530 +فينا خلل في ال permeability بتاعة ال potassium و + +232 +00:17:11,530 --> 00:17:15,470 +ال sodium للخلية وهذا بتصير في حالات قديمة بنلاقي + +233 +00:17:15,470 --> 00:17:21,240 +من 20 إلى 30% Stomatocytes في ال blood film ممكن + +234 +00:17:21,240 --> 00:17:24,740 +يصير فيها mild to severe hemolytic anemia هي الـ + +235 +00:17:24,740 --> 00:17:31,200 +Stomatocytes بشكل واضح كتير فيها نيجي + +236 +00:17:31,200 --> 00:17:34,440 +للـ Acanthocytes الـ Acanthocytes اللي هي زي ما أنتوا + +237 +00:17:34,440 --> 00:17:40,300 +شايفين كأنها spiculated cell خلية إلها خطاطيف هذا + +238 +00:17:40,300 --> 00:17:43,020 +بيكون ناتج عن خلل في الـ lipids الـ Beta + +239 +00:17:43,020 --> 00:17:47,120 +-Lipoprotein اللي هي مكونة للـ cell membrane أو من + +240 +00:17:47,120 --> 00:17:50,370 +مكونات الـ cell membrane فبالتالي بتلاقي خلل في + +241 +00:17:50,370 --> 00:17:55,870 +تركيبة الـ Cell Membrane بيؤدى لحدوث هذا الشكل هي + +242 +00:17:55,870 --> 00:18:00,730 +خليط الـ Acanthocytes طبعا هنلاقي كمية الـ + +243 +00:18:00,730 --> 00:18:05,070 +Acanthocytes في السمير يعني كبيرة وموجودة وملحوظة + +244 +00:18:05,070 --> 00:18:09,370 +حسب الحالة أو حسب المشكلة بينتج عنها Mild Anemia + +245 +00:18:09,370 --> 00:18:13,650 +ممكن يسموها اسم تانى Beta-Lipoproteinemia يعني ان + +246 +00:18:13,650 --> 00:18:16,890 +في خلل في الـ Beta-Lipoprotein المكون للـ Cell + +247 +00:18:16,890 --> 00:18:17,450 +Membrane + +248 +00:18:22,170 --> 00:18:27,610 +طيب النوع التاني احنا اول اش يقولنا خلل بالـ cell + +249 +00:18:27,610 --> 00:18:32,130 +membrane و ذكرنا الأشكال خلل في ال enzymes اللي + +250 +00:18:32,130 --> 00:18:34,990 +موجودة بالخلايا من ال enzymes اللي ممكن يشتغل فيها + +251 +00:18:34,990 --> 00:18:38,810 +مشاكل الـ Pyruvate Kinase والجلوكوز 6-phosphate + +252 +00:18:38,810 --> 00:18:42,940 +في الـ Pyruvate Kinase بيبقى فيه خلل في الـ Glucose 6-Phosphate Dehydrogenase + +253 +00:18:42,940 --> 00:18:47,380 +في تكوين الـ ATP طبعا الـ ATP مسؤولة بشكل كبير عن + +254 +00:18:47,380 --> 00:18:50,520 +وظائف كتير في الخلية من ضمن الوظائف المسؤولة عنها + +255 +00:18:50,520 --> 00:18:53,880 +الـ ATP اللي هي Sodium Potassium Pump اللي هي الـ + +256 +00:18:53,880 --> 00:18:57,440 +Cation Pump طبعا وجود خلل أو تلف في Sodium + +257 +00:18:57,440 --> 00:19:00,680 +Potassium Pump هيعمل عندي هذا الشكل الـ Abnormal + +258 +00:19:00,680 --> 00:19:04,060 +للخلايا وهذه بتكون مساحبة بـ Severe Hemolytic + +259 +00:19:04,060 --> 00:19:07,960 +Anemia وبنشوف فيها الـ Echinocytes اللي هي الخلايا + +260 +00:19:07,960 --> 00:19:11,880 +الـ Crenated بهذا الشكل بتكون موجودة في الـ + +261 +00:19:11,880 --> 00:19:15,560 +Peripheral blood تمام؟ هي حالة Pyruvate Kinase + +262 +00:19:15,560 --> 00:19:19,860 +Deficiency طيب، نيجي للـ Glucose-6-Phosphate + +263 +00:19:19,860 --> 00:19:24,600 +Deficiency هنا زي ما احنا عارفين أن الهيموجلوبين + +264 +00:19:24,600 --> 00:19:29,920 +في الوضع الطبيعي بيكون على شكل فروس ومجرد ما يتحول + +265 +00:19:29,920 --> 00:19:35,850 +لفرق لأي مؤثر أو أي Oxidant في ميكانيزم بالجسم + +266 +00:19:35,850 --> 00:19:41,750 +الميكانيزم هذه بترجع عن طريق الـ NADPH وبتروح و + +267 +00:19:41,750 --> 00:19:45,470 +هي مرجعة على فروس على أساس إنه يقوم بوظيفته + +268 +00:19:45,470 --> 00:19:48,310 +لكن لو ضلوا على شكل فرق اللي بسميه الـ Hemoglobin + +269 +00:19:48,310 --> 00:19:51,050 +في هذه الحالة Met-Hemoglobin راح يكون non + +270 +00:19:51,050 --> 00:19:54,370 +-functional هدول الناس عندهم خلل في الـGlucose-6 + +271 +00:19:54,370 --> 00:19:57,470 +-Phosphate اللي داخل في الـ pathway تتكوين الـNADPH + +272 +00:19:57,470 --> 00:20:01,110 +وبالتالي لما يكون فيه نقص في الـNADPH لو + +273 +00:20:01,110 --> 00:20:07,060 +الـHemoglobin صار له Oxidation مش هيقدر يرجع + +274 +00:20:07,060 --> 00:20:10,760 +للأصل برجع بالـ pathway هذا اللي هو added by NADPH + +275 +00:20:10,760 --> 00:20:15,940 +اللي هو added by Glucose 6-Phosphate Dehydrogenase طالما هذا مش + +276 +00:20:15,940 --> 00:20:19,200 +موجود الـ NADPH مش هيتقوم بشكل كافي فبالتالي هيظل + +277 +00:20:19,200 --> 00:20:24,200 +الـ Hemoglobin على شكل Methemoglobin وطبعا هدول + +278 +00:20:24,200 --> 00:20:27,100 +الناس زي ما أنتم عارفين بيكونوا موجودين أو عايشين + +279 +00:20:27,100 --> 00:20:30,780 +بشكل طبيعي يوم اللي يتعرضوا لـ Oxidant هتلاقي أنه + +280 +00:20:30,780 --> 00:20:35,460 +صار Oxidation عندهم وصارت عندهم اللي هي الأعراض + +281 +00:20:35,460 --> 00:20:39,660 +فبالتالي هم طالما مافيش Oxidant هم عايشين بشكل + +282 +00:20:39,660 --> 00:20:42,880 +طبيعي لكن لو اتعرضوا لـ Oxidant هيتكون عندهم + +283 +00:20:42,880 --> 00:20:47,480 +Heinz bodies الـ Heinz bodies في الخلية هتأدي إلى + +284 +00:20:47,480 --> 00:20:50,920 +الـ RBCs destruction هي هنا بقولك هذا الفيلم تبعهم + +285 +00:20:50,920 --> 00:20:54,660 +لو كانوا طبيعيين بدون ما يتعرضوا لأي Oxidant + +286 +00:21:01,090 --> 00:21:06,250 +نأتي هنا لو أتعرضوا لـ Oxidant أيش راح يصير معهم + +287 +00:21:06,250 --> 00:21:11,990 +هنلاحظ أنه هيتكون عندهم الـ Heinz Body طبعا لما + +288 +00:21:11,990 --> 00:21:15,450 +يتكون الـ Heinz Body بيروح على الخلايا هذه هتروح + +289 +00:21:15,450 --> 00:21:20,210 +هيصير فيها هتبدأ الـ Macrophage تعملها Piting + +290 +00:21:20,210 --> 00:21:25,510 +هتعضها يعني هتقدم هذا الجزء وممكن بالتالي يعود الـ + +291 +00:21:25,510 --> 00:21:29,230 +Cell Membrane يلتقم فبالتالي الخلية ممكن تصير + +292 +00:21:29,230 --> 00:21:33,980 +Spherocyte هدول الناس بلاقي عندهم Schistocyte، + +293 +00:21:33,980 --> 00:21:38,000 +Spherocyte due to pitting of Heinz bodies by + +294 +00:21:38,000 --> 00:21:42,040 +Spleen بنلاقي عندهم moderate to severe anemia طبعا + +295 +00:21:42,040 --> 00:21:45,840 +هذه أفضل طريقة لإن هي الأشكال اللي بشوف ممكن أشوف + +296 +00:21:45,840 --> 00:21:49,480 +Schistocyte ممكن أشوف Schistocyte وأشكال مختلفة + +297 +00:21:49,480 --> 00:21:53,530 +damaged RBCs أفضل طريقة للـdiagnosis لإلهام اللي + +298 +00:21:53,530 --> 00:21:57,130 +هو Enzyme Assay نعمل نسبة الـGlucose 6-Phosphate + +299 +00:21:57,130 --> 00:22:00,710 +الموجودة في الـRBCs وبنقرر إذا كان Normal أو + +300 +00:22:00,710 --> 00:22:06,490 +Abnormal نيجي + +301 +00:22:06,490 --> 00:22:11,310 +الخلل التالت اللي هو نتيجة خلل بالـHemoglobin يعني + +302 +00:22:11,310 --> 00:22:15,750 +الـHemoglobin نفسه في مشكلة هذا عادة بيكون + +303 +00:22:15,750 --> 00:22:21,650 +Inherited طبعا معظم الحالات دي هنلاقي فيها Target + +304 +00:22:21,650 --> 00:22:25,750 +cells من الأمثلة اللي هي Beta Chain Amino Acid + +305 +00:22:25,750 --> 00:22:29,190 +Substitution بتطلع عندنا Variant Hemoglobin يعني + +306 +00:22:29,190 --> 00:22:32,150 +بيصير عندنا خلل في الـ Beta Chain ده بيصير استبدال + +307 +00:22:32,150 --> 00:22:36,510 +Amino Acid بـ Amino Acid تاني من الأمثلة اللي هو + +308 +00:22:36,510 --> 00:22:40,110 +Hemoglobin S و Hemoglobin C Hemoglobin S بيصير + +309 +00:22:40,110 --> 00:22:40,790 +Substitution + +310 +00:22:43,840 --> 00:22:47,460 +للـ Glutamic Acid بالـ Valine بينما Hemoglobin C + +311 +00:22:47,460 --> 00:22:52,460 +للـ Glutamic Acid بيصير له Substitution بالـ Lysine + +312 +00:22:52,460 --> 00:22:54,880 +فبننشأ عندي نوعين من الـ Hemoglobin الـ Abnormal + +313 +00:22:54,880 --> 00:23:01,140 +Hemoglobin S و Hemoglobin C يبنيج + +314 +00:23:01,140 --> 00:23:03,860 +لـ Hemoglobin S أو Sickle Cell Anemia طبعا أنتم + +315 +00:23:03,860 --> 00:23:07,280 +عارفينها الـ Sickle Cell Anemia في عندي Two S-Gene + +316 +00:23:07,280 --> 00:23:13,660 +ممكن يكون واحد فيهم Affected وممكن اثنين طبعا + +317 +00:23:13,660 --> 00:23:17,140 +فبتكون Sickle Cell Anemia أو Sickle Cell Trait + +318 +00:23:17,140 --> 00:23:23,160 +هنا بقولك هذه الحالة بتكون Asymptomatic بعد 6 شهور + +319 +00:23:23,160 --> 00:23:27,400 +ممكن تبدأ الـ Symptoms تظهر عليهم ليش Asymptomatic؟ + +320 +00:23:27,400 --> 00:23:30,740 +لأن الطفل في هذه الفترة بيكون عنده الـ Hemoglobin F + +321 +00:23:30,740 --> 00:23:35,460 +مرتفع و الـ Hemoglobin F مافيه Beta-Chain فيه Gamma + +322 +00:23:35,460 --> 00:23:38,760 +Chain فبالتالي ما راح يبين عنده الخلل غير لما + +323 +00:23:38,760 --> 00:23:42,860 +يبدأ Hemoglobin F ينزل ويرفع Hemoglobin A طبعا + +324 +00:23:42,860 --> 00:23:45,580 +Hemoglobin A مش هيتكون بشكل كامل لأن الـ Beta + +325 +00:23:45,580 --> 00:23:49,280 +Chain اللي في Hemoglobin A Affected فهذا راح يؤدي + +326 +00:23:49,280 --> 00:23:54,020 +لإنه هيبدأ يتكون عنده الـ Sickle Cell بعد 6 شهور و + +327 +00:23:54,020 --> 00:23:58,380 +تبدأ تظهر عنده الأعراض ليش؟ لأنه صار يتكون عنده + +328 +00:23:58,380 --> 00:24:02,980 +Hemoglobin S طبعا زي ما قلنا المشكلة بتكون إذا كان + +329 +00:24:02,980 --> 00:24:06,920 +SS يعني Two Genes Affected لكن لو كان واحد + +330 +00:24:06,920 --> 00:24:11,040 +Affected تبقى عندهم يعني مابيبقاش عندهم أعراض إلا + +331 +00:24:11,040 --> 00:24:15,080 +إذا يعني اتعرضوا لظروف حادة من نقص الأكسجين ممكن + +332 +00:24:15,080 --> 00:24:18,800 +يظهر عندهم Mild Problem فدول الناس اللي عندهم + +333 +00:24:18,800 --> 00:24:23,220 +Trait طبعا يعني بس من رعيهم في الـ .. في الـ .. يعني + +334 +00:24:23,220 --> 00:24:26,000 +مثلا في الطيران في الصعود إلى الأماكن المرتفعة + +335 +00:24:26,000 --> 00:24:31,370 +لازم يبقى في تزويد لهم بالأكسجين وبالتالي بيعيشوا + +336 +00:24:31,370 --> 00:24:33,890 +حياتهم طبيعي ما عندهم مشاكل المشكلة عند مين عنده + +337 +00:24:33,890 --> 00:24:38,510 +الـ Sickle Cell Anemia هدول هلاقي عندهم Severe + +338 +00:24:38,510 --> 00:24:42,810 +Anemia هلاقي عندهم Target Cells هلاقي عندهم Sickle + +339 +00:24:42,810 --> 00:24:46,250 +Cells هي الـ Target Cell وهي Sickle Cell اللي هي + +340 +00:24:46,250 --> 00:24:49,350 +شكلين زي ما قلنا Filamentous Form and Wood Form + +341 +00:24:49,350 --> 00:24:53,030 +هنلاقي هذا في حالة الـ Sickling هنلاقي عندهم + +342 +00:24:53,030 --> 00:24:58,170 +Nucleated RBCs ليش؟ لأنه الـ Vulnerable Active + +343 +00:24:58,460 --> 00:25:02,100 +هيصير يطلع عندي Nucleated RBCs و Reticulocyte بشكل + +344 +00:25:02,100 --> 00:25:06,680 +كبير هدول طبعا علاقة عندهم Hemoglobin A مش موجود + +345 +00:25:06,680 --> 00:25:09,800 +خالص لأن Hemoglobin A شرط في تكوين وجود الـ Beta + +346 +00:25:09,800 --> 00:25:13,520 +-Chain هدول ما عندهم الـ Beta-Chain وإنما علاقة + +347 +00:25:13,520 --> 00:25:17,880 +عندهم تقريبا من 80 إلى 100% Hemoglobin S مع ارتفاع + +348 +00:25:17,880 --> 00:25:20,540 +في أنواع الـHemoglobin الأخرى اللي ما فيها الـBeta + +349 +00:25:20,540 --> 00:25:26,820 +-Chain زي Hemoglobin F هاي + +350 +00:25:26,820 --> 00:25:31,610 +بقولك عن الـTrait هنا جين واحد اللي Affected عادة + +351 +00:25:31,610 --> 00:25:34,430 +Asymptomatic ممكن أشوف في بعض الأحيان عندهم Target + +352 +00:25:34,430 --> 00:25:37,910 +cells نوع Anemia or Sickle Cell عندهم Hemoglobin A + +353 +00:25:37,910 --> 00:25:43,570 +بشكل تقريبا 60% و40% Hemoglobin S طبعا Potential + +354 +00:25:43,570 --> 00:25:47,950 +Problems of Hypoxia يعني ممكن يتعرضوا لبعض المشاكل + +355 +00:25:47,950 --> 00:25:55,810 +في ظروف الـHypoxia بس نيجي + +356 +00:25:55,810 --> 00:26:01,340 +للـ Hemoglobin C Disease طبعا هنا هنلاقي الـ Two + +357 +00:26:01,340 --> 00:26:05,180 +Genes Two Beta Chain Affected وتم استبدال الـ Beta + +358 +00:26:05,180 --> 00:26:08,620 +Chain تم استبدال الـ Glutamic Acid فيهم بالـ Lysine + +359 +00:26:08,620 --> 00:26:12,840 +فبنتج عندي Hemoglobin C طبعا Hemoglobin C هيعمل + +360 +00:26:12,840 --> 00:26:16,000 +Crystallization في داخل الخلية ويظهر كـ Block زي ما + +361 +00:26:16,000 --> 00:26:18,800 +أنتم شايفين هذا هو في داخل الخلية الـ Hemoglobin + +362 +00:26:18,800 --> 00:26:22,500 +C Crystals بنتج عنه Mild Anemia Target Cells + +363 +00:26:22,500 --> 00:26:26,880 +Intracellular Hemoglobin C Hemoglobin A مش هتلاقي + +364 +00:26:26,880 --> 00:26:33,400 +Hemoglobin A أكثر من 90% هتلاقي Hemoglobin-C الحالة + +365 +00:26:33,400 --> 00:26:38,260 +التانية أنه يبقى One Beta Chain Affected One Gene + +366 +00:26:38,260 --> 00:26:41,820 +في + +367 +00:26:41,820 --> 00:26:45,520 +تعويض الـ Beta Chain يعطيني Hemoglobin-C هنا + +368 +00:26:45,520 --> 00:26:49,640 +هتلاقيها Asymptomatic with No Anemia ممكن ألاقي + +369 +00:26:49,640 --> 00:26:53,760 +Target Cells مش هشوف Hemoglobin-C Crystals علاقة من + +370 +00:26:53,760 --> 00:27:00,120 +تقريبا 60% Hemoglobin-A و40% Hemoglobin-C برضه هنا + +371 +00:27:00,120 --> 00:27:03,160 +علاقة الـ Hemoglobin-A تكون Normal و Hemoglobin-F + +372 +00:27:03,160 --> 00:27:07,800 +هيكون برضه Normal نيجي + +373 +00:27:07,800 --> 00:27:12,700 +للـ Hemoglobin-S-C Disease هنا بيبقى في عنده الـ + +374 +00:27:12,700 --> 00:27:16,700 +Two Beta Chain Affected واحدة فيهم تعطيني + +375 +00:27:16,700 --> 00:27:20,480 +Hemoglobin-S يعني صار فيها Substitution مختلفة عن + +376 +00:27:20,480 --> 00:27:28,060 +الثانية الثانية بتعطيني Hemoglobin C طيب هنا هاي + +377 +00:27:28,060 --> 00:27:31,580 +هنا هذا شرح للحالة double heterozygous inherit + +378 +00:27:31,580 --> 00:27:36,280 +sickle gene from one parent and C gene from the other + +379 +00:27:36,280 --> 00:27:41,500 +parent both beta chain are abnormal ال lab finding + +380 +00:27:41,500 --> 00:27:44,700 +intermediate in severity هتلاقي ال severity بتاعة + +381 +00:27:44,700 --> 00:27:48,020 +الحالة متوسطة ما بين ال sickle cell أنميا و sickle + +382 +00:27:48,020 --> 00:27:48,600 +cell trait + +383 +00:27:51,930 --> 00:27:57,430 +هنلاقي فيه Target Cells هنلاقي SC Crystals مش + +384 +00:27:57,430 --> 00:28:04,330 +هتلاقي Hemoglobin A هتلاقي 50% Hemoglobin S و 50% + +385 +00:28:04,330 --> 00:28:08,370 +Hemoglobin C نيجي + +386 +00:28:08,370 --> 00:28:13,310 +للـ Acquired Hemolytic Anemia النوع الثاني + +387 +00:28:13,310 --> 00:28:16,370 +Acquired Hemolytic Anemia طبعا هنا الخلية بتتكون + +388 +00:28:16,370 --> 00:28:20,580 +صح مش فيها ولا غلطة لكن ظروف خارجية بتأثر على + +389 +00:28:20,580 --> 00:28:23,740 +الخلية بصيرها تكسير زي الـ Immune-mediated + +390 +00:28:23,740 --> 00:28:27,180 +destruction Red Cell Fragmentation Disorder + +391 +00:28:27,180 --> 00:28:32,660 +Acquired Membrane Defects Spleen Defects هذه مشاكل + +392 +00:28:32,660 --> 00:28:38,420 +بتأثر على الخلية و بتخليها تتكسر طبعا هذه الأسباب + +393 +00:28:38,420 --> 00:28:42,500 +يعني ممكن يكون إيش سببها ممكن يكون Immune + +394 +00:28:42,500 --> 00:28:47,390 +Hemolytic Anemia قد تكون Warm أو Cold Warm + +395 +00:28:47,390 --> 00:28:51,330 +Autoimmune Hemolytic Anemia هنا المشكلة أنه بتكون + +396 +00:28:51,330 --> 00:28:55,570 +للـ Self-antigen Auto-antibodies وعادة بتكون Warm + +397 +00:28:55,570 --> 00:29:01,670 +Antibodies من النوع IgG طبعاً هترتبط مع الخلية أو + +398 +00:29:01,670 --> 00:29:04,490 +تعمل sensitization للخلية ممكن يصير complement + +399 +00:29:04,490 --> 00:29:10,310 +activation أو sensitization فهتروح هذه الخلية على + +400 +00:29:10,310 --> 00:29:14,890 +الـSpleen الـSpleen فيها الفاجوسيتس هتعمل لها + +401 +00:29:15,390 --> 00:29:19,050 +Partial Phagocytosis يعني هتعمل بيت لل .. اللي هو + +402 +00:29:19,050 --> 00:29:21,530 +الـ Antibody اللي عانى ال sensitization للخلية + +403 +00:29:21,530 --> 00:29:26,170 +بيصير عندي خلية Spherocyte طبعا بعد هيك هيصير عندي + +404 +00:29:26,170 --> 00:29:31,410 +lysis لهذه الخلايا قد يكون السبب idiopathic أو + +405 +00:29:31,410 --> 00:29:33,950 +secondary نتيجة disease آخر يعني ممكن يكون ال + +406 +00:29:33,950 --> 00:29:37,270 +primary أنه فيه auto antibodies بس يعني مش معروف + +407 +00:29:37,270 --> 00:29:40,690 +إيش السبب ممكن يكون نتيجة مرض آخر يزول بزوال + +408 +00:29:40,690 --> 00:29:43,510 +المؤثر هي شكل ال blood film فيه عدد من ال + +409 +00:29:43,510 --> 00:29:48,630 +Spherocyte موجودة في الخلية شايفين كيف؟ ممكن أشوف + +410 +00:29:48,630 --> 00:29:53,290 +فيها abnormality ممكن أشوف polychromasia ال + +411 +00:29:53,290 --> 00:29:56,330 +polychromasia دي إيش قولنا عنها؟ هي ال + +412 +00:29:56,330 --> 00:30:02,710 +reticulocyte ال immature erythrocyte طيب ال lab + +413 +00:30:02,710 --> 00:30:06,670 +finding هنلاقي حسب طبعا الحالة moderate to severe + +414 +00:30:06,670 --> 00:30:11,400 +anemia ممكن أشوف الـ Spherocytes ممكن أشوف ال .. + +415 +00:30:11,400 --> 00:30:15,720 +طبعا وين في Spherocyte حاجة الـ MCHC مرتفعة ممكن + +416 +00:30:15,720 --> 00:30:19,340 +أشوف شكل اللي هو الـ Erythrophagocytosis يعني أشوف + +417 +00:30:19,340 --> 00:30:23,580 +Erythrocyte صار لها Phagocytosis ليش؟ لأنه هذه الـ + +418 +00:30:23,580 --> 00:30:27,100 +Erythrocyte تحسست بالـ Antibody فبالتالي هتيجي ال + +419 +00:30:27,100 --> 00:30:30,120 +Phagocyte تعمل لها Phagocytosis يعني هنا هي عنا واضح + +420 +00:30:30,120 --> 00:30:32,840 +Monocyte عاملة Phagocytosis ل Erythrocyte + +421 +00:30:38,420 --> 00:30:41,480 +طبعاً الـ Blood Film تبعها بشبه الـ Hereditary + +422 +00:30:41,480 --> 00:30:45,520 +Spherocytosis لكن فيه فرق إن الـ Direct + +423 +00:30:45,520 --> 00:30:48,760 +Antiglobulin Test فيها بيكون Positive أو إله اسم + +424 +00:30:48,760 --> 00:30:51,780 +ثاني اللي هو الـ Combs Test فده كتير مهم في + +425 +00:30:51,780 --> 00:30:56,620 +التمييز بين أنواع الـ Hemolytic Anemia إذا كان الـ + +426 +00:30:56,620 --> 00:31:00,320 +Combs Test Positive أو ده الـ Test اسمه Positive + +427 +00:31:00,320 --> 00:31:04,370 +هناخد نبذة عنه إن شاء الله في معمل المناعة إذا كان + +428 +00:31:04,370 --> 00:31:07,750 +هذا الفحص positive معنى الكلام إنه هذه autoimmune + +429 +00:31:07,750 --> 00:31:11,750 +hemolytic anemia إيش هو هذا الـDAT أو الكومس بيكشف + +430 +00:31:11,750 --> 00:31:14,910 +عن وجود sensitized cells بيكشف عن وجود خلايا + +431 +00:31:14,910 --> 00:31:21,170 +متحسسة نتيجة أفعال مناعية طبعا الخلايا لأنها صارت + +432 +00:31:21,170 --> 00:31:24,750 +spherocyte هنلاقي ال osmotic fragility ارتفعت + +433 +00:31:24,750 --> 00:31:29,110 +طالما زادت تكسير هتلاقي ال bilirubin برضه ارتفع + +434 +00:31:29,110 --> 00:31:32,670 +أضف لإنه هتلاقي erythroid hyperplasia + +435 +00:31:36,110 --> 00:31:39,730 +نيجي إلى الـ Cold Autoimmune Hemolytic Anemia هنا + +436 +00:31:39,730 --> 00:31:43,810 +يا بنات، في عندي Antibodies للخلايا لكن هاد الـ + +437 +00:31:43,810 --> 00:31:48,310 +Antibodies من نوع IgM و بتتميز بإنها Cold بمعنى + +438 +00:31:48,310 --> 00:31:52,270 +إنه يعني عادة ما بتشتغل على ال body temperature + +439 +00:31:52,270 --> 00:31:59,370 +لكن ممكن تشتغل على ال room temperature يعني في هذه + +440 +00:31:59,370 --> 00:32:02,310 +الحلقة لو أنا أجيت سحبت عينة تراكتها شوية حتى + +441 +00:32:02,310 --> 00:32:05,150 +أتلاقي العينة عملت Autoagglutination لكن في بعض + +442 +00:32:05,150 --> 00:32:08,080 +الأحيان هتلاقي الـ antibody أو الـ complement + +443 +00:32:08,080 --> 00:32:12,040 +component ارتبطت على سطح الخلايا وعملت complement + +444 +00:32:12,040 --> 00:32:15,720 +activation وحيصير agglutination and lyses by + +445 +00:32:15,720 --> 00:32:20,180 +complement or macrophage ممكن تكون primary أو + +446 +00:32:20,180 --> 00:32:22,060 +secondary لديزيز معين + +447 +00:32:24,660 --> 00:32:29,080 +الـ Lab finding هنلاقي agglutination للـ RBC في + +448 +00:32:29,080 --> 00:32:32,860 +الأطراف زي الأماكن الباردة اللي ممكن تتعرض لدرجة + +449 +00:32:32,860 --> 00:32:38,360 +حرارة باردة زي الأذن الأصابع الأنف هذا طبعا راح + +450 +00:32:38,360 --> 00:32:42,400 +يؤدي إلى tissue damage ممكن يؤدي إلى مضاعفات خطيرة + +451 +00:32:42,400 --> 00:32:47,250 +زي الـ necrosis والجانجرين Severity varies with + +452 +00:32:47,250 --> 00:32:52,150 +seasons Avoid the cold يعني حدة المرض بتعتمد على + +453 +00:32:52,150 --> 00:32:56,430 +الجو فبالتالي بتزيد في الأجواء الباردة ليش؟ لأن + +454 +00:32:56,430 --> 00:33:00,050 +الـ IGM بارد مش تغير درجة الحرارة الباردة IGM + +455 +00:33:00,050 --> 00:33:03,410 +antibodies causes RBCs agglutination هنشوف + +456 +00:33:03,410 --> 00:33:05,790 +agglutination واضحة للـ blood film لو أنا عملت + +457 +00:33:05,790 --> 00:33:09,270 +blood film هنلاقي reticulocytosis كرد فعل لتكسير + +458 +00:33:09,270 --> 00:33:13,490 +الخلايا بصير تنشيط للـ bone marrow هنلاقي positive + +459 +00:33:13,490 --> 00:33:17,530 +direct antiglobulin test detect complement طبعا يا بنات بشكل أساسي + +460 +00:33:17,530 --> 00:33:19,970 +الـ IGM هو اللي بيعمل activation للـ complement + +461 +00:33:19,970 --> 00:33:23,870 +فبالتالي الـ complement لما بتتنشط ممكن تعمل + +462 +00:33:23,870 --> 00:33:27,010 +sensitization للخلايا فبالتالي بكشف عنها بالـ + +463 +00:33:27,010 --> 00:33:29,830 +direct antiglobulin test أو بالـ Combs test إذا + +464 +00:33:29,830 --> 00:33:33,590 +كنتوا فاكرين توي قلتلكم الـ Combs test بعمل كشف لل + +465 +00:33:33,590 --> 00:33:37,910 +sensitization بالـ antibody وبرضه بعمل كشف لل + +466 +00:33:37,910 --> 00:33:41,290 +sensitization بالـ Combs test بالـ .. بالـ عفو بالـ + +467 +00:33:41,290 --> 00:33:44,110 +complement هلاقيت إذا صار الـ sensitization بالـ + +468 +00:33:44,110 --> 00:33:47,070 +complement بفهم إنه هذا ال antibody IgM لأن هو + +469 +00:33:47,070 --> 00:33:50,190 +اللي بيعمل أغلبا activation لل complement إذا صار + +470 +00:33:50,190 --> 00:33:53,410 +ال sensitization ب antibody فبفهم إنه IgG + +471 +00:34:09,500 --> 00:34:17,740 +هنا أنا طبعا بروح بنقل وحدة الدم وحدة الدم هذه هيكون + +472 +00:34:17,740 --> 00:34:23,840 +فيها بعض الـ Antigens الـ Antigens هذه لن تتوافق + +473 +00:34:23,840 --> 00:34:26,720 +مع ال patient يعني ال patient عنده antibodies لها + +474 +00:34:26,720 --> 00:34:31,200 +يعني ال recipient عنده antibody X ونقلتله Antigen + +475 +00:34:31,200 --> 00:34:35,920 +X هيصير أكيد reaction وبالتالي هيصير تكسير لخلايا + +476 +00:34:35,920 --> 00:34:40,050 +ال donor أسوأ واحد فيهم اللي هو الـ ABO + +477 +00:34:40,050 --> 00:34:43,730 +Incompatibility طبعا أنتم ما بتعرفوش غيره في عندي + +478 +00:34:43,730 --> 00:34:46,450 +أنواع ثانية من الـ Incompatibility هتاخدوها في بنك + +479 +00:34:46,450 --> 00:34:51,510 +الدم لكن بنحكي أكثر واحد بيعمل مشاكل اللي هو الـ + +480 +00:34:51,510 --> 00:34:55,210 +ABO Blood Group System بيعمل Intravascular + +481 +00:34:55,210 --> 00:35:00,730 +Hemolysis ليش؟ لأن هنا ال reaction بيكون strong + +482 +00:35:01,160 --> 00:35:04,080 +والـ Antibody is strong فبتعمل Intravascular + +483 +00:35:04,080 --> 00:35:07,140 +Hemolysis نتيجة الـ Complement Activation يعني ما + +484 +00:35:07,140 --> 00:35:10,120 +بيستنى الـ Antibody يعمل Synthetization ويروح + +485 +00:35:10,120 --> 00:35:14,260 +هالسبلين لسه وهناك يصير له تكسير زي الـ IgG ثم + +486 +00:35:14,260 --> 00:35:18,260 +مباشرة هيصير له تكسير في الـ Peripheral Blood فيما + +487 +00:35:18,260 --> 00:35:21,500 +يسمى الـ Intravascular Hemolysis طبعا ممكن يعمل + +488 +00:35:21,500 --> 00:35:25,180 +بلوك للنفرون للمصفاة الكلوية الـ Antigen Antibody + +489 +00:35:25,180 --> 00:35:28,300 +Complexes وممكن يكون Alive with Retaining + +490 +00:35:32,370 --> 00:35:37,870 +نيجي للـHemolytic Disease of the newborn طبعا هذه + +491 +00:35:37,870 --> 00:35:42,190 +بنات يعني أنا دائما بذكركم فيه اللي هو عامل Rhesus + +492 +00:35:42,190 --> 00:35:46,490 +إذا كان فيش توافق بين فصيلة الأم والطفل إيش ممكن + +493 +00:35:46,490 --> 00:35:52,450 +يصير؟ ممكن عند قطع الحبل السري تنتقل بعض الخلايا + +494 +00:35:52,450 --> 00:35:57,330 +اللي قد تعتبر فيها Antigens غريبة إلى الأم احنا + +495 +00:35:57,330 --> 00:36:03,830 +دائما المثال الشائع عندنا اللي هو الـ Rh صح؟ هو في + +496 +00:36:03,830 --> 00:36:08,150 +أشياء ثانية لكن الأكثر شيوعا الـ Rh هلاقيت عند قطع + +497 +00:36:08,150 --> 00:36:11,530 +الحبل السري إذا كان الطفل موجب و الأم negative + +498 +00:36:11,530 --> 00:36:17,210 +هتنتقل خلايا موجبة إلى الأم وبالتالي هتعتبر خلايا + +499 +00:36:17,210 --> 00:36:21,570 +غريبة فهيتكون لها antibodies فلاقيت الأم تكون + +500 +00:36:21,570 --> 00:36:26,810 +عندها anti نقول مجازن Anti-D عن الـ Rh لأن الـ Rh + +501 +00:36:26,810 --> 00:36:30,640 +مجموعة من الأنتيجينات أهم واحد فيهم الـ D فالأم حيصير + +502 +00:36:30,640 --> 00:36:33,900 +عندها Anti-D فلاقيت الـ Anti-D هذا مش هيأذى الطفل + +503 +00:36:33,900 --> 00:36:36,700 +الأول لكن لو حملت مرة ثانية بطفل عنده الـ D + +504 +00:36:36,700 --> 00:36:40,600 +-Antigen أو الـ Rh Positive هينتقل الـ Anti-D + +505 +00:36:40,600 --> 00:36:46,280 +للطفل ويعمل تكسير للخلايا تبعته فهينشق Hemolytic + +506 +00:36:46,280 --> 00:36:50,340 +Disease of a Newborn وبتتميز ذات الـ Rh بأنها + +507 +00:36:50,340 --> 00:36:55,320 +بتعمل Severe Anemia وحنلاقي فيها Nucleated R + +508 +00:36:55,320 --> 00:36:59,770 +-Pieces تمام؟ طبعاً أنتم عارفين إيش علاجها إنه + +509 +00:36:59,770 --> 00:37:04,870 +إحنا بنعطي الأم بمجرد ما تولد اللي هو إبرة إيش + +510 +00:37:04,870 --> 00:37:11,990 +الإبرة هذه؟ هي عبارة عن Anti-D جاهز بحيث إنه أي + +511 +00:37:11,990 --> 00:37:15,790 +خلية أي خلية تمرق من الطفل للأم تم تكسيرها مباشرة + +512 +00:37:15,790 --> 00:37:20,250 +قبل ما يتكون لها antibodies طيب + +513 +00:37:20,250 --> 00:37:24,310 +الـHemolytic Disease due to ABO incompatibility + +514 +00:37:24,310 --> 00:37:27,690 +يعني في عندنا Hemolytic Disease بس مش نتيجة الـ RH + +515 +00:37:27,690 --> 00:37:34,090 +نتيجة الـ ABO هذه أمتى بتصير؟ بتصير إذا كانت الأم + +516 +00:37:34,090 --> 00:37:38,590 +فصلتها O إذا كانت الأم طبعا مش دائماً هذه يعني مش + +517 +00:37:38,590 --> 00:37:43,450 +شائعة الحدوث إذا كانت الأم فصلتها O هيكون عندها + +518 +00:37:43,450 --> 00:37:49,550 +Anti-A و Anti-B وهدول Anti-A و Anti-B ممكن فيهم + +519 +00:37:49,550 --> 00:37:52,370 +IgG ممكن يخترقوا الـ placenta يعني ممكن يخترقوا + +520 +00:37:52,370 --> 00:37:56,080 +المشيمة أو يوصلوا للطفل فرضاً كان الطفل فصيلته A + +521 +00:37:56,080 --> 00:38:00,580 +أو B ووصله من الأم Anti-A أو Anti-B ممكن يصير عنده + +522 +00:38:00,580 --> 00:38:04,020 +Mild Hemolysis بس ما بتطور لأنيميا وبنشوف عنده + +523 +00:38:04,020 --> 00:38:08,700 +Spherocytes هذا مش كتير common لأن الـ Rh أنتجنز + +524 +00:38:08,700 --> 00:38:12,480 +عفواً الـ ABO أنتجنز نفسها ما بتكونش لسه مكتملة + +525 +00:38:12,480 --> 00:38:15,780 +بشكل كافي عند الطفل انها تعمل reaction على خلاف + +526 +00:38:15,780 --> 00:38:17,760 +الـ Rh اللي هو الأكثر شيء عندي + +527 +00:38:21,550 --> 00:38:26,190 +نجي للـ Hemolytic Anemia due to trauma طبعاً أنه + +528 +00:38:26,190 --> 00:38:29,990 +Hemolytic Anemia ساقنة يعني صار تعرض لـ External + +529 +00:38:29,990 --> 00:38:35,390 +trauma أفرت على الخلايا فعملت لها تكسير + +530 +00:38:35,390 --> 00:38:41,390 +Fragmentation Syndrome ممكن تكون mechanical زي + +531 +00:38:41,390 --> 00:38:45,970 +الناس اللي هي بتركب صممات قلب صناعية مرور الخلايا + +532 +00:38:45,970 --> 00:38:50,180 +عبر الصمام هذا ممكن يعمل فيها damage أو حالة + +533 +00:38:50,180 --> 00:38:53,620 +بيسموها microangiopathic microangiopathic تبقى ال + +534 +00:38:53,620 --> 00:39:00,460 +blood vessels أكثر دقيقة دقيقة جداً طبعاً هذه ممكن + +535 +00:39:00,460 --> 00:39:04,900 +يصير تكثير للخلايا وممكن تتطور لحالات DIC و + +536 +00:39:04,900 --> 00:39:07,760 +bleeding disseminated intravascular coagulation + +537 +00:39:08,750 --> 00:39:13,750 +مارش مغلوبينيوريا طبعاً هذه تيجي للعدائين اللي + +538 +00:39:13,750 --> 00:39:16,890 +بيجروا مسافات طويلة ممكن يصير عندهم تكسير في ال + +539 +00:39:16,890 --> 00:39:21,030 +blood نتيجة الحركة السريعة والاحتكاك المفاصل طبعاً + +540 +00:39:21,030 --> 00:39:26,450 +هذه طبعاً بتزول بزوال المؤثر ممكن نشوف فيها + +541 +00:39:26,450 --> 00:39:31,830 +مغلوبينيوريا نيجي + +542 +00:39:31,830 --> 00:39:35,830 +للـ hemolytic anemia اللي شايبة من infectious agents + +543 +00:39:35,830 --> 00:39:41,440 +and bears طبعاً هنا الانيميا يعني بعض الأشياء اللي + +544 +00:39:41,440 --> 00:39:45,180 +ممكن تعمل infection بعض الـ agent ممكن تعمل عندي + +545 +00:39:45,180 --> 00:39:51,560 +أنيميا أو تكثير بالـ RBC أو واحد تعرض لحروق أو تعرض + +546 +00:39:51,560 --> 00:39:56,020 +لحروق طبعاً هنا الانيميا حسب الشدة بتكون حسب المؤثر + +547 +00:39:56,020 --> 00:39:59,340 +اللي تعرض له هذا الشخص هي ممكن ألاقي Schistocyte أو + +548 +00:39:59,340 --> 00:40:04,960 +Spherocyte في blood smear عندنا من الأمثلة بعض + +549 +00:40:04,960 --> 00:40:08,720 +البرازايتز زي الملاريا البرازايتز هذه هتعطيني + +550 +00:40:08,720 --> 00:40:12,400 +lightening toxin ممكن تعمل license للـ RBCs أو + +551 +00:40:12,400 --> 00:40:14,900 +cause direct damage to red cell membrane هلأ هي + +552 +00:40:14,900 --> 00:40:20,200 +خلال فترة التكاثر تبعتها الملاريا أنه بتتكاثر في + +553 +00:40:20,200 --> 00:40:23,100 +داخل الارترسايت وبعدين بيصير license للـ RBCs عشان + +554 +00:40:23,100 --> 00:40:26,720 +ينطلق هذا يطلع هذا البرازايتز اللي اتكاثر في قلب + +555 +00:40:26,720 --> 00:40:29,810 +الارترسايتز فإما عن طريق الـ «توكسين» اللي بتفرزها + +556 +00:40:29,810 --> 00:40:34,990 +أو عن طريق التكسيق أو الـ «license» المباشر للـ + +557 +00:40:34,990 --> 00:40:38,270 +Cell Membrane إيه في حالات الـ Clostridium برضه + +558 +00:40:38,270 --> 00:40:40,670 +اللي بتعمل «توكسين»؟ حلائق «شيستوسايت» وحلائق + +559 +00:40:40,670 --> 00:40:46,010 +«سبيروسايتروز» هيك + +560 +00:40:46,010 --> 00:40:50,530 +نكون خلصنا الأنميا يعطيكم ألف عافية بعد هيك راح + +561 +00:40:50,530 --> 00:40:55,070 +ننتقل لمرحلة ثانية في الانيميا اللي هي أنا بعتبرها + +562 +00:40:55,070 --> 00:40:58,250 +الأهم وهي مرحلة الـ Case Studies diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..c7682c058257689182030c731a6b7b1ccae26be1 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_postprocess.srt @@ -0,0 +1,2248 @@ +1 +00:00:01,690 --> 00:00:06,950 +الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبابتتقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +التلاتة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش أني أحفظ إيش تعريف الانيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش ال pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط النتائج هذه مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مساحبة لهذا ال result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات عشان أتأكد من الـresults معينة هذا + +20 +00:01:32,370 --> 00:01:36,290 +الكلام بإذن الله كله راح نناقشه مع بعض شويه شويه + +21 +00:01:36,290 --> 00:01:40,670 +أول حاجة هنشرحه ثالثا + +22 +00:01:40,670 --> 00:01:46,010 +الـ normocytic normochromic anemia خلايا تتميز بأن + +23 +00:01:46,010 --> 00:01:49,970 +حجمها طبيعي والـ hemoglobin content لها طبيعي لكن + +24 +00:01:49,970 --> 00:01:55,630 +فينا حالة أنيمية فينا نقص في + +25 +00:01:55,760 --> 00:01:59,380 +Normochromic Anemia زي ما قلنا الـ Size and + +26 +00:01:59,380 --> 00:02:02,480 +Hemoglobin content is normal but the number of + +27 +00:02:02,480 --> 00:02:06,200 +RBCs decreased يعني الخلل بيكون في عدد الـ RBCs ما + +28 +00:02:06,200 --> 00:02:10,760 +اتأثر أي إشي في الـ erythrocyte نفسها في شكلها في + +29 +00:02:10,760 --> 00:02:14,960 +حجمها في كمية الـ Hemoglobin لكن اللي بتغير عدد + +30 +00:02:14,960 --> 00:02:20,300 +الـ RBCs طبعا هذه إلها أسباب أسبابها الأبلاستيك + +31 +00:02:20,300 --> 00:02:24,160 +أنيميا due to bone marrow failure يعني فينا مشكلة + +32 +00:02:24,160 --> 00:02:28,090 +في الـ bone marrowبلاد لوس أنيميا في عندي أنيميا + +33 +00:02:28,090 --> 00:02:32,450 +سببها فقد كميات من البلد hemolytic anemia + +34 +00:02:32,450 --> 00:02:36,390 +للابلاستيك + +35 +00:02:36,390 --> 00:02:40,890 +أنيميا المشكلة في البون مارو condition of blood + +36 +00:02:40,890 --> 00:02:44,910 +banned cytopenia caused by bone marrow failure + +37 +00:02:44,910 --> 00:02:48,510 +يعني بيبقى في عندنا في البون في البون مارووبالتالي + +38 +00:02:48,510 --> 00:02:52,590 +بتلاقي كل الـ Parameters بتاعة الـ CBC Low من الـ + +39 +00:02:52,590 --> 00:02:56,250 +YPCs من الـ RBCs من الـ Platelets كله بتلاقيهم + +40 +00:02:56,250 --> 00:03:00,750 +الخفضDecreased production of all cell lines and + +41 +00:03:00,750 --> 00:03:05,510 +replacement of marrow with fat هتلاقي أن البون + +42 +00:03:05,510 --> 00:03:09,310 +مارو صار replacement لإله بالـ Yellow marrow + +43 +00:03:09,310 --> 00:03:14,950 +بالفتر طبعا هذا بيكون سببه due to damaged stem + +44 +00:03:14,950 --> 00:03:18,630 +cellsdamage bone marrow environment or suppression + +45 +00:03:18,630 --> 00:03:24,650 +بيصير خلل في الstem cells فبالتالي بينشق عنه + +46 +00:03:24,650 --> 00:03:29,430 +suppression للـ bone marrow في هذه الحالة ما بيصير + +47 +00:03:29,430 --> 00:03:34,250 +تعويض يعني ما بيصير extra medullary hematopoiesis + +48 +00:03:34,250 --> 00:03:37,770 +احنا قلنا ان في بعض الأحيان لما بيصير تكسير في ال + +49 +00:03:37,770 --> 00:03:43,010 +RBCs بيصير extra medullary hematopoiesis عشان يعود + +50 +00:03:43,010 --> 00:03:47,610 +الخلل اللي صار أو النقص اللي صارلكن في هذه الحالة + +51 +00:03:47,610 --> 00:03:50,850 +ما بيصير فبالتالي بيظل الـ hemoglobin و ال + +52 +00:03:50,850 --> 00:03:56,750 +parameters الأخرى كلها منخفضة إيش أنواع ال + +53 +00:03:56,750 --> 00:04:02,330 +aplastic anemia؟ ال aplastic anemia نوعين أو تلت + +54 +00:04:02,330 --> 00:04:06,050 +أنواع رئيسية الأكثر شيوع النوعين اللي هو ال + +55 +00:04:06,050 --> 00:04:09,810 +primary و ال secondary ال primary بيبقى خلل أساسا + +56 +00:04:09,810 --> 00:04:13,250 +في ال hormonal بيبقى سببه idiopathic ال secondary + +57 +00:04:13,820 --> 00:04:18,660 +عادة بتبقى acquired جاية نتيجة تعرض ال patient + +58 +00:04:18,660 --> 00:04:23,900 +لchemicals لبعض الدراجات لinfections لردياشن طبعا + +59 +00:04:23,900 --> 00:04:30,120 +هذه بتشكل تقريبا 50% وهذه بتشكل 50% في نسبة بسيطة + +60 +00:04:30,120 --> 00:04:34,580 +يعني ممكن يكون سببها congenital اللي هي فانكانس + +61 +00:04:34,580 --> 00:04:39,300 +أنيميا هذه بتلاقي أبلاجيا نقص في كل ال parameters + +62 +00:04:39,300 --> 00:04:43,200 +يعني نفس ال picture بتاعة الأبلاستيك أنيميابتكون + +63 +00:04:43,200 --> 00:04:48,820 +مصاحبة بـ dwarfism وبتكون معاها كمان skeletal + +64 +00:04:48,820 --> 00:04:52,940 +abnormalities شوية mental retardation abnormal + +65 +00:04:52,940 --> 00:04:57,400 +skin pigmentation يعني هتلاقي فيه تلون في ال skin + +66 +00:04:57,400 --> 00:05:02,880 +بالاضافة لأقزمة قصر في القانة كمان بتلاقي تشوه في + +67 +00:05:02,880 --> 00:05:05,860 +ال skeletal bone + +68 +00:05:10,870 --> 00:05:14,270 +diagnosis of aplastic anemia أول حاجة قلنا احنا + +69 +00:05:14,270 --> 00:05:18,330 +سمناها normocytic-normochromic فهتلاقي ان ال MCV و + +70 +00:05:18,330 --> 00:05:24,030 +ال MCH و ال MCHC normal ال reticulocyte low ليش + +71 +00:05:24,030 --> 00:05:27,850 +low؟ لأنه أساسا مافيش تنبيه للبون مرة أنه يصنع + +72 +00:05:27,850 --> 00:05:31,490 +خلايا فبالتالي هتلاقي في كسل في البون مرة فبتلاقي + +73 +00:05:31,490 --> 00:05:35,170 +مش هتلاقي يعني فبالتالي مش هنلاقي reticulocyte + +74 +00:05:35,170 --> 00:05:39,530 +normal هنلاقيها قليلة هنلاقي نقص في ال hemoglobin + +75 +00:05:39,950 --> 00:05:44,470 +زي ما قلنا band-cytopenia مش هنلاقي أي abnormal + +76 +00:05:44,470 --> 00:05:47,150 +cells يعني كل الخلايا هتلاقيها normal لا هتلاقي + +77 +00:05:47,150 --> 00:05:49,770 +abnormality في الـ size ولا هتلاقي abnormality في + +78 +00:05:49,770 --> 00:05:55,150 +الشباب hypoplegia of bone marrow يعني تفبيط أو قلة + +79 +00:05:55,150 --> 00:05:58,610 +في نشاط الـ bone marrow بقى ال parameters التانية + +80 +00:05:58,610 --> 00:06:03,410 +زي ال serum iron ال vitamin B12 الفولات هتلاقيهم + +81 +00:06:03,410 --> 00:06:06,430 +normal هتلاقيهماش normal + +82 +00:06:13,210 --> 00:06:16,370 +نأتي إلى الـ Hemolytic Anemia النوع التاني إذا + +83 +00:06:16,370 --> 00:06:19,390 +النوع الأول حكينا عنه أبلاستيك أنيميا النوع التاني + +84 +00:06:19,390 --> 00:06:24,410 +هو Hemolytic Anemia الـ Hemolytic Anemia بيكون + +85 +00:06:24,410 --> 00:06:30,310 +بسبب زيادة في تكسير الـ premature red cells قد + +86 +00:06:30,310 --> 00:06:35,170 +تكون compensated أو uncompensated يعني ممكن بون + +87 +00:06:35,170 --> 00:06:39,450 +مارو يقدر يتعامل معاها وممكن ما يقدر يتعامل معاها + +88 +00:06:39,450 --> 00:06:44,130 +حسب ال rate of hemolysisطبعا الـ Hemolytic Anemia + +89 +00:06:44,130 --> 00:06:47,870 +بتؤدي لإيش لـ Hyperplasia مافي عندنا مشكلة في الـ + +90 +00:06:47,870 --> 00:06:52,390 +Boomerang و هذا بيترتب عنه إن الـ Erythroid + +91 +00:06:52,390 --> 00:06:55,910 +precursors بتصير تنشط فبتلاقي الـ Myeloid + +92 +00:06:55,910 --> 00:06:59,490 +Erythroid Ratio انخفضت لأن الـ Erythroid بتزيد + +93 +00:06:59,490 --> 00:07:04,210 +Boomerang Red Cells Production increase 6 to 8 + +94 +00:07:04,210 --> 00:07:07,990 +times يعني بتزيد من 6 إلى 8 مرات الوضع الطبيعي + +95 +00:07:07,990 --> 00:07:12,370 +برضه ال reticulocyte هتلاقيها مرتفعةmarked + +96 +00:07:12,370 --> 00:07:16,770 +reticulocytosis ونلاقي كمان inucleated RBCs في الـ + +97 +00:07:16,770 --> 00:07:24,170 +peripheral blood الآن + +98 +00:07:24,170 --> 00:07:28,130 +بالنسبة لتكسير الخلايا في الـ hemolytic anemia قد + +99 +00:07:28,130 --> 00:07:31,970 +تكون بسبب intravascular hemolysis يعني في داخل ال + +100 +00:07:31,970 --> 00:07:34,770 +blood vessels في الcirculation أو يكون ال + +101 +00:07:34,770 --> 00:07:38,190 +hemolysis extravascular في ال reticuloendothelial + +102 +00:07:38,190 --> 00:07:38,850 +system + +103 +00:07:42,650 --> 00:07:46,850 +نجي للنوع الأول اللي هو الـ Extravascular + +104 +00:07:46,850 --> 00:07:51,950 +Hemolysis الـ Extravascular Hemolysis هنلاحظ فيه + +105 +00:07:51,950 --> 00:07:56,530 +إن هو بيمشي بنفس ال pathway الطبيعي اللي بيصير فيه + +106 +00:07:56,530 --> 00:08:00,410 +تكسير لل RBCs لما يصير لها aging لكن على وطيرة + +107 +00:08:00,410 --> 00:08:03,950 +أسرع يعني إحنا عارفين إن ال RBCs لما يصير لها + +108 +00:08:03,950 --> 00:08:12,040 +aging طبعا بالإضافة لل abnormal RBCsهتروح على الـ + +109 +00:08:12,040 --> 00:08:15,600 +reticuloendothelial system هناك الـ macrophages + +110 +00:08:15,600 --> 00:08:18,740 +هتعملها removal طبعا ال reticuloendothelial system + +111 +00:08:18,740 --> 00:08:23,100 +عارفين بومار و لفرقة عصبين هناك هيصير تكسير لل + +112 +00:08:23,100 --> 00:08:27,860 +RBCs هلأ لما بيصير لل RBCs تكسير هيصير طبعا + +113 +00:08:27,860 --> 00:08:33,680 +بالنسبة للهيموجلوبين هيصير release للهيم أندجلوبين + +114 +00:08:34,150 --> 00:08:38,690 +الجلوبين هيروح ويكوّن أخر أمينو أسد طبعاً الأمينو + +115 +00:08:38,690 --> 00:08:43,110 +أسد هتستخدم لـ protein synthesis بضل عندنا الهيم + +116 +00:08:43,110 --> 00:08:46,250 +الهيم بتكون من iron بيصير له reabsorption عشان + +117 +00:08:46,250 --> 00:08:50,810 +يستخدم مرة أخرى و بعدين الهيم الهيم طبعاً عفوا + +118 +00:08:50,810 --> 00:08:55,410 +البروتوبرفيرين البروتوبرفيرين هيصير له تكسير و + +119 +00:08:55,410 --> 00:08:59,450 +هيتحول ل unconjugated bilirubin طبعا ال + +120 +00:08:59,450 --> 00:09:05,310 +unconjugated bilirubin هذا يعني بيكون موجوداللي + +121 +00:09:05,310 --> 00:09:09,010 +بالـ reticuloendothelial system بشكل عام بده ينتقل + +122 +00:09:09,010 --> 00:09:12,810 +للـ liver علشان ينتقل بال liver هو water insoluble + +123 +00:09:12,810 --> 00:09:17,410 +فبالتالي بيرتبط بالألبومين بروح هناك بدخل ال liver + +124 +00:09:17,410 --> 00:09:21,650 +فبترك الألبومين طبيعي الألبومين كان كناقل بس لما + +125 +00:09:21,650 --> 00:09:27,200 +بدخل لل liverبيصير له esterification بإضافة two + +126 +00:09:27,200 --> 00:09:31,000 +glucuronic acid فبتحول ل conjugated bilirubin + +127 +00:09:31,000 --> 00:09:35,560 +فالconjugated bilirubin هينزل على ال intestine من + +128 +00:09:35,560 --> 00:09:39,840 +ال liver عبر ال bile duct لل intestine طبعا هذا + +129 +00:09:39,840 --> 00:09:42,740 +جزء من انه هيصير له reabsorption عن طريق ال + +130 +00:09:42,740 --> 00:09:47,760 +intestineويتحول لـ Yerobilinogen و Yerobiline + +131 +00:09:47,760 --> 00:09:50,460 +طبعاً هيعود بعد نسير الـ absorption يمشي في الـ + +132 +00:09:50,460 --> 00:09:53,220 +blood وبعدين يروح لل urine وينزل على شكل + +133 +00:09:53,220 --> 00:09:57,780 +Yerobilinogen هذه هي ال pathway بتاعة التكسير + +134 +00:09:57,780 --> 00:10:02,060 +الطبيعي اللي بتصير في الجسم يعني هذه لما بيصير + +135 +00:10:02,060 --> 00:10:05,680 +aging للخلايا هيك بتتأثر في الـ Extravascular + +136 +00:10:05,680 --> 00:10:10,360 +Hemolysis هذا اللي بيصير بس بوتيرة عالية يعني مش + +137 +00:10:10,360 --> 00:10:16,420 +بالشكل الطبيعي اللي بيصيرزيادة الـ RBCD breakdown + +138 +00:10:16,420 --> 00:10:20,660 +طبعاً الـ bilirubin هيرتفع ليش؟ لأنه زاد التكسير + +139 +00:10:20,660 --> 00:10:25,500 +فزاد التكسير البروتوبرفيرين تحوله لـ bilirubin + +140 +00:10:25,500 --> 00:10:29,480 +وبالتالي هيبلش الـ bilirubin يرتفع stool + +141 +00:10:29,480 --> 00:10:32,900 +ياروبايلينوجين و blood yaroboilinogen و urine + +142 +00:10:32,900 --> 00:10:35,580 +yaroboilinogen هدول نوادج الـ bilirubin كلها + +143 +00:10:35,580 --> 00:10:41,440 +هنلاقيها انها ارتفعت هذا إذن وان في الـ + +144 +00:10:41,440 --> 00:10:42,940 +Extravascular Hemolysis + +145 +00:10:46,970 --> 00:10:51,250 +الـ Intravascular Hemolysis هنا بيصير التكسير في + +146 +00:10:51,250 --> 00:10:54,470 +داخل الـ blood vessels بيصير في داخل الـ blood + +147 +00:10:54,470 --> 00:10:59,770 +vessels والهيموجلوبين هذا عادة عادة ممكن يصير + +148 +00:10:59,770 --> 00:11:05,670 +نتيجة complement activation يعني ممكن يكون نتيجة + +149 +00:11:05,670 --> 00:11:12,230 +immune hemolysis وتحفيز للـ complement فما يعني ما + +150 +00:11:12,230 --> 00:11:15,010 +بيروح الـ radiculoendothelial system بتكسر في داخل + +151 +00:11:15,010 --> 00:11:19,300 +الـ circulationهذا بنتج عنه وجود إكسرة الخلية + +152 +00:11:19,300 --> 00:11:21,700 +هيطلع الـ Hemoglobin منها الأصل إن الـ Hemoglobin + +153 +00:11:21,700 --> 00:11:24,680 +ما بيكون free في ال blood هنا حيصير في عندنا free + +154 +00:11:24,680 --> 00:11:29,280 +Hemoglobin طبعا الـ free Hemoglobin بده ينتقل للـ + +155 +00:11:29,280 --> 00:11:33,560 +liver كيف بينتقل عن طريق الـ Heptoglobin اللي هو + +156 +00:11:33,560 --> 00:11:38,120 +البروتين ال carrier للـ Hemoglobin الـ Heptoglobin + +157 +00:11:38,120 --> 00:11:42,580 +هنا هتنقص كميتو لأنه هيصير saturated أو منشغل و + +158 +00:11:42,580 --> 00:11:47,650 +مرتبط بالـ Hemoglobinطيب فى كمية من الـ Hemoglobin + +159 +00:11:47,650 --> 00:11:51,490 +برضه هتظل Free هيصيرلها في التراشن عبر الكدنى + +160 +00:11:51,490 --> 00:11:56,410 +Aglomeruli الآن لو كان ال rate للـ Hemolysis كتير + +161 +00:11:56,410 --> 00:11:59,490 +كبير وما .. يعني ماقدرش يعمل Reabsorption للـ + +162 +00:11:59,490 --> 00:12:02,330 +Hemoglobin اللى بينزل هيبدأ يطلع عند Free + +163 +00:12:02,330 --> 00:12:06,370 +Hemoglobin ينزل في ال urine هناك في ال bladder + +164 +00:12:06,370 --> 00:12:12,230 +هيوصل لـ bladder طبعا وهيبدأشكمية من الـ + +165 +00:12:12,230 --> 00:12:16,690 +Hemocydrine تترثب أو تتكون في الـ urine وألاخظها + +166 +00:12:16,690 --> 00:12:20,590 +أو ألاقيها بشكل واضح، إذن هنا في الـ Intravascular + +167 +00:12:20,590 --> 00:12:25,050 +Hemolysis بتميز بإنه فيه Free Hemoglobin ونشأ عنه + +168 +00:12:25,050 --> 00:12:29,130 +Heptoglobin، بعدين في الـ urine بلاقي Hemocydrine + +169 +00:12:29,130 --> 00:12:34,170 +Hemoglobinuria + +170 +00:12:34,170 --> 00:12:39,680 +الـ Lab Features، وجود Hemoglobin في الـ urineأو + +171 +00:12:39,680 --> 00:12:42,260 +Hemoglobinemia يعني وجود Hemoglobin في blood أو + +172 +00:12:42,260 --> 00:12:45,760 +Hemoglobin يوريا وفي ال urine Hemocydrinuria وجود + +173 +00:12:45,760 --> 00:12:49,380 +Hemocydrin في ال urine Reduced or absent serum + +174 +00:12:49,380 --> 00:12:52,880 +haptoglobin لأنه هتلاقي ارتبط بال Hemoglobin عشان + +175 +00:12:52,880 --> 00:13:00,080 +يودي لل metabolism نيجي + +176 +00:13:00,080 --> 00:13:04,040 +لأنواع ال Hemolytic Anemia بداية ال Hereditary + +177 +00:13:04,040 --> 00:13:10,000 +Hemolytic Anemiaطبعا هنا هذه عادة بتكون congenital + +178 +00:13:10,000 --> 00:13:15,120 +ممكن تبين بداية عند الولادة أو ممكن خلال مراحل + +179 +00:13:15,120 --> 00:13:19,700 +الحياة في بعضها بيضل silent يعني مافيش عليه مافيش + +180 +00:13:19,700 --> 00:13:24,760 +ال patient عليه أي أعراض لغاية ما يتعرض لمؤثر يبين + +181 +00:13:24,760 --> 00:13:32,440 +هذه المشكلة زي الـ G6PD ممكن طيب هذه إيش أسبابها + +182 +00:13:32,440 --> 00:13:37,700 +أسبابها خلالفي الـ Red Cell قد يكون السبب هذا + +183 +00:13:37,700 --> 00:13:44,600 +نتيجة Membrane defect أو خلل في الـ Metabolism طيب + +184 +00:13:44,600 --> 00:13:49,520 +نيجي أول حاجة لمشاكل بالـ membrane defect مشاكل + +185 +00:13:49,520 --> 00:13:53,260 +الـ membrane defect قد تكون يعني من أمثلتها + +186 +00:13:53,260 --> 00:13:56,120 +Spherocytosis وElliptocytosis اللي بتنشأ عنها + +187 +00:13:56,120 --> 00:13:59,800 +أشكال abnormal للخلايا والأشكال هذه هيصير لها أكيد + +188 +00:13:59,800 --> 00:14:05,570 +تكسيرهنا مثلا نجي لـ Spherocytosis Spherocytosis + +189 +00:14:05,570 --> 00:14:09,950 +هنا بيصير خلل في الاسبكتين و الانكايرين دول + +190 +00:14:09,950 --> 00:14:11,630 +التانين المسؤولين عن + +191 +00:14:14,560 --> 00:14:17,640 +الـ Flexibility بتاعة الـ Erythrocyte يعني انه الـ + +192 +00:14:17,640 --> 00:14:21,340 +biconcave shape تبعها مسؤولين عنه زي الـ rubber زي + +193 +00:14:21,340 --> 00:14:24,460 +المغاطة بيبقوا في الخلية داخل الخلية خيوط من + +194 +00:14:24,460 --> 00:14:27,500 +البروتين مسؤولين عن شكل الـ biconcave بتاع الخلية + +195 +00:14:27,500 --> 00:14:31,180 +فإذا صار فقد فيهم أو نقص فيهم هتبدأ الخلية تاخد + +196 +00:14:31,180 --> 00:14:34,740 +الـ Spherocyte أضف إلى بعض الحالات اللي بيبقى فيها + +197 +00:14:34,740 --> 00:14:39,080 +خلل بال permeability بتاعة الممبرينفبالتالي بتزود + +198 +00:14:39,080 --> 00:14:44,840 +تدخيل الـ Sodium ions لداخل الخلية وبالتالي بتبعها + +199 +00:14:44,840 --> 00:14:49,080 +الميّه وفي بعض الحالات ممكن تكون نتيجة Hemolytic + +200 +00:14:49,080 --> 00:14:54,920 +Anemia زي في حالات الـ Autoimmune Hemolytic Anemia + +201 +00:14:54,920 --> 00:14:59,200 +المرحلة يعني لما بيصير complement fixation هتبدأ + +202 +00:14:59,200 --> 00:15:02,760 +الخلية يصيرلها perforation لما بيصير perforation + +203 +00:15:02,760 --> 00:15:05,460 +الخلية هتبلش ال fluids تدخل فيها في كمية كبيرة + +204 +00:15:05,460 --> 00:15:09,490 +فهتصير Spherocyteو بعد هيك هيصير لها Rapture هنا + +205 +00:15:09,490 --> 00:15:13,090 +بيبين عندنا لما بيصير جزء يعني لصلة جزء من الـ + +206 +00:15:13,090 --> 00:15:17,770 +membrane كيف ممكن خلية تتحول إلى Spherocyte ال lab + +207 +00:15:17,770 --> 00:15:21,510 +finding طبعا الانيميا بتكون مختلفة يعني مش كل + +208 +00:15:21,510 --> 00:15:24,590 +الحالات على نفس ال degree من الانيميا حلاق + +209 +00:15:24,590 --> 00:15:30,550 +Spherocyte في السمير هتلاقي ال MCHC مرتفع فلقيت يا + +210 +00:15:30,550 --> 00:15:36,380 +بنات اتطلعوا معايا الخلية هذه هي Spherocyteالخلية + +211 +00:15:36,380 --> 00:15:41,900 +هنا أصار يعني أصارت الخلية منتفخة واختفى فيها الـ + +212 +00:15:41,900 --> 00:15:45,680 +Biconcave shape هذه الخلايا الـ Serocyte يعني هي + +213 +00:15:45,680 --> 00:15:50,740 +اللى بنربطها دايما بارتفاع الـ MCHC وارتفاع الـ + +214 +00:15:50,740 --> 00:15:55,640 +MCHالـ MCH-C والـ MCH ارتفاعهم لحاله لا يعني شيء + +215 +00:15:55,640 --> 00:15:59,340 +لكن عادة هو مرتبط بالـ Spherocyte لأنه فلاقى أن + +216 +00:15:59,340 --> 00:16:02,400 +الـ Cell Membrane تاع الخلية صغر شوية فبالتالي + +217 +00:16:02,400 --> 00:16:06,540 +صارت نسبة الـ Hemoglobin فيها مرتفعة الـ MCH-C + +218 +00:16:06,540 --> 00:16:10,800 +فيها مرتفع يعني a high body chromia Increased + +219 +00:16:10,800 --> 00:16:13,860 +Osmotic Fragility Test وهذا طبعا الفحص إذا كنتوا + +220 +00:16:13,860 --> 00:16:18,000 +فاكرين اللي بيميز الـ Spherocytosis فحص الـ + +221 +00:16:18,000 --> 00:16:19,080 +Osmotic Fragility + +222 +00:16:21,790 --> 00:16:26,010 +نأتي للـ ovalocytosis أو الابتو سايتوزز بتكون + +223 +00:16:26,010 --> 00:16:30,890 +الخلية شكلها رفيعة زي ما أنتوا شايفين هنا + +224 +00:16:30,890 --> 00:16:38,130 +ovalocyte شايفين كيف شكلها هنا هذا بيكون سببه أنه + +225 +00:16:38,130 --> 00:16:41,430 +أصار polarization للكلسترال أو للهيموجلوبيين عند + +226 +00:16:41,430 --> 00:16:47,570 +أطراف الخلية فأخدت هذا الشكل هنلاقي تقريبا 25% أو + +227 +00:16:47,570 --> 00:16:52,310 +أكثر of ovalocytes عادة بتكون asymptomaticما بدون + +228 +00:16:52,310 --> 00:16:58,510 +أعراض يعني ممكن تنشأ عنا mild anemia الـ + +229 +00:16:58,510 --> 00:17:01,790 +Stomatocytosis هي شكل الخلية زي ما أنتوا فاكرين + +230 +00:17:01,790 --> 00:17:06,150 +فيها slit في الوسط زي فتحة زي شق بسيط هنا بيبقى + +231 +00:17:06,150 --> 00:17:11,530 +فينا خلل في ال permeability بتاعة ال potassium و + +232 +00:17:11,530 --> 00:17:15,470 +ال sodium للخلية وهذا بتصير في حالات قديمة بنلاقي + +233 +00:17:15,470 --> 00:17:21,240 +من 20 إلى 30% stomatocyte في ال blood filmممكن + +234 +00:17:21,240 --> 00:17:24,740 +يصير فيها mild to severe hemolytic anemia هي الـ + +235 +00:17:24,740 --> 00:17:31,200 +Stomatocyte بشكل واضح كتير فيها نيجي + +236 +00:17:31,200 --> 00:17:34,440 +للـ Acantocyte الـ Acantocyte اللي هي زي ما أنتوا + +237 +00:17:34,440 --> 00:17:40,300 +شايفين كأنها Speculated cell خلية إلها خطاطيف هذا + +238 +00:17:40,300 --> 00:17:43,020 +بيكون ناتج عن خلل في الـ lipids الـ Beta + +239 +00:17:43,020 --> 00:17:47,120 +-Lipoprotein اللي هي مكونة للـ cell membrane أو من + +240 +00:17:47,120 --> 00:17:50,370 +مكونات الـ cell membraneفبالتالي بتلاقي خلل في + +241 +00:17:50,370 --> 00:17:55,870 +تركيبة الـ Cell Membrane بيؤدى لحدوث هذا الشكل هي + +242 +00:17:55,870 --> 00:18:00,730 +خليط الـ Acanthocyte طبعا هنلاقي كمية الـ + +243 +00:18:00,730 --> 00:18:05,070 +Acanthocyte في السمير يعني كبيرة وموجودة وملحوظة + +244 +00:18:05,070 --> 00:18:09,370 +حسب الحالة أو حسب المشكلة بينتج عنها Mild Anemia + +245 +00:18:09,370 --> 00:18:13,650 +ممكن يسموها اسم تانى Beta-Lipoproteinemia يعني ان + +246 +00:18:13,650 --> 00:18:16,890 +في خلل في الـ Beta-Lipoprotein المكون للـ Cell + +247 +00:18:16,890 --> 00:18:17,450 +Membrane + +248 +00:18:22,170 --> 00:18:27,610 +طيب النوع التاني احنا اول اش يقولنا خلل بالـ cell + +249 +00:18:27,610 --> 00:18:32,130 +membrane و ذكرنا الأشكال خلل في ال enzymes اللي + +250 +00:18:32,130 --> 00:18:34,990 +موجودة بالخلايا من ال enzymes اللي ممكن يشتغل فيها + +251 +00:18:34,990 --> 00:18:38,810 +مشاكل الـ pyruvate kinase والجلوكوز 6-phosphate + +252 +00:18:38,810 --> 00:18:42,940 +dehydrogenaseفي الـ Pyruvate Kinase بيبقى فيه خلل + +253 +00:18:42,940 --> 00:18:47,380 +في تكوين الـ ATP طبعا الـ ATP مسؤولة بشكل كبير عن + +254 +00:18:47,380 --> 00:18:50,520 +وظائف كتير في الخلية من ضمن الوظائف المسؤولة عنها + +255 +00:18:50,520 --> 00:18:53,880 +الـ ATP اللي هي Sodium Potassium Pump اللي هي الـ + +256 +00:18:53,880 --> 00:18:57,440 +Cation Pump طبعا وجود خلل أو تلف في Sodium + +257 +00:18:57,440 --> 00:19:00,680 +Potassium Pump هيعمل عندى هذا الشكل الـ Abnormal + +258 +00:19:00,680 --> 00:19:04,060 +للخلايا وهذه بتكون مساحبة بـ Severe Hemolytic + +259 +00:19:04,060 --> 00:19:07,960 +Anemiaوبنشوف فيها الـ Echinocytes اللي هي الخلايا + +260 +00:19:07,960 --> 00:19:11,880 +الـ Crenated بهذا الشكل بتكون موجودة في الـ + +261 +00:19:11,880 --> 00:19:15,560 +Peripheral blood تمام؟ هي حالة Pyruvate Kinase + +262 +00:19:15,560 --> 00:19:19,860 +Deficiency طيب، نيجي للـ Glucose-6-Fosfate + +263 +00:19:19,860 --> 00:19:24,600 +Deficiency هنا زي ما أحنا عارفين أن الهيمoglobin + +264 +00:19:24,600 --> 00:19:29,920 +في الوضع الطبيعي بيكون على شكل فرص ومجرد ما يتحول + +265 +00:19:29,920 --> 00:19:35,850 +لفرق لأي مؤثر أو أي Oxidantفي ميكانيزم بالجسم + +266 +00:19:35,850 --> 00:19:41,750 +الميكانيزم هذه بترجع عن طريق الـ Net pH و بتروح و + +267 +00:19:41,750 --> 00:19:45,470 +هي مرجعة على ash لفرس على أساس إنه يقوم بوظيفته + +268 +00:19:45,470 --> 00:19:48,310 +لكن لو ضلوا على شكل فرق اللي بسميه الـ Hemoglobin + +269 +00:19:48,310 --> 00:19:51,050 +في هذه الحالة مت-Hemoglobin راح يكون non + +270 +00:19:51,050 --> 00:19:54,370 +-functional هدول الناس عندهم خلل في الـGlucose-6 + +271 +00:19:54,370 --> 00:19:57,470 +-Fosfate اللي داخل في ال pathway تتكوين الـNet pH + +272 +00:19:57,470 --> 00:20:01,110 +وبالتالي لما يكون فيه نقص في الـNet pH لو + +273 +00:20:01,110 --> 00:20:07,060 +الـHemoglobin صار لهأو Oxidation مش هيقدر يرجع + +274 +00:20:07,060 --> 00:20:10,760 +والأصل برجع بال pathway هذا اللي هو added by NADPH + +275 +00:20:10,760 --> 00:20:15,940 +اللي هو added by Glucosic Phosphate طالما هذا مش + +276 +00:20:15,940 --> 00:20:19,200 +موجود الـ NADPH مش هيتقوم بشكل كافي فبالتالي هيظل + +277 +00:20:19,200 --> 00:20:24,200 +ال Hemoglobin على شكل Methemoglobin وطبعا هدول + +278 +00:20:24,200 --> 00:20:27,100 +الناس زي ما انتوا عارفين بيكونوا موجودين أو عايشين + +279 +00:20:27,100 --> 00:20:30,780 +بشكل طبيعي يوم اللي يتعرضوا ل Oxidant هتلاقي أنه + +280 +00:20:30,780 --> 00:20:35,460 +صار Oxidationعندهم وصارت عندهم اللي هي الأعراض + +281 +00:20:35,460 --> 00:20:39,660 +فبالتالي هم طالما مافيش Occident هم عايشين بشكل + +282 +00:20:39,660 --> 00:20:42,880 +طبيعي لكن لو اتعرضوا لـ Occident هيتكون عندهم + +283 +00:20:42,880 --> 00:20:47,480 +hence bodies الـ hence bodies في الخلية هتأدي إلى + +284 +00:20:47,480 --> 00:20:50,920 +الـ RBCs destruction هي هنا بقولك هذا الفيلم تبعهم + +285 +00:20:50,920 --> 00:20:54,660 +لو كانوا طبيعيين بدون ما يتعرضوا لأي Occident + +286 +00:21:01,090 --> 00:21:06,250 +نأتي هنا لو أتعرضوا لـ Oxidant أيش راح يصير معهم + +287 +00:21:06,250 --> 00:21:11,990 +هنلاحظ أنه هيتكوّن عندهم الـ Hense Body طبعاً لما + +288 +00:21:11,990 --> 00:21:15,450 +يتكوّن الـ Hense Body بيروح على الخلايا هذه هتروح + +289 +00:21:15,450 --> 00:21:20,210 +هيصير فيها هتبدأ الـ Macrophage تعملها Biting + +290 +00:21:20,210 --> 00:21:25,510 +هتعضها يعني هتقدم هذا الجزء وممكن بالتالي يعود الـ + +291 +00:21:25,510 --> 00:21:29,230 +Cell Membrane يلتقم فبالتالي الخلية ممكن تصير + +292 +00:21:29,230 --> 00:21:33,980 +Spherocyteهدول الناس بلاقي عندهم schistocyte، + +293 +00:21:33,980 --> 00:21:38,000 +spherocyte due to pitting of hen's bodies by + +294 +00:21:38,000 --> 00:21:42,040 +spleen بنلاقي عندهم moderate to severe anemia طبعا + +295 +00:21:42,040 --> 00:21:45,840 +هذه أفضل طريقة لإن هي الأشكال اللي بشوف ممكن أشوف + +296 +00:21:45,840 --> 00:21:49,480 +schistocyte ممكن أشوف schistocyte وأشكال مختلفة + +297 +00:21:49,480 --> 00:21:53,530 +damaged herpesأفضل طريقة لل-diagnosis لإلهام اللي + +298 +00:21:53,530 --> 00:21:57,130 +هو enzyme assay نعمل نسبة الـGlucose 6-وثفات + +299 +00:21:57,130 --> 00:22:00,710 +الموجودة في الـRBCs وبنقرر إذا كان Normal أو + +300 +00:22:00,710 --> 00:22:06,490 +Abnormal نيجي + +301 +00:22:06,490 --> 00:22:11,310 +الخلل التالت اللي هو نتيجة خلل بالـHemoglobin يعني + +302 +00:22:11,310 --> 00:22:15,750 +الـHemoglobin نفسه في مشكلة هذا عادة بيكون + +303 +00:22:15,750 --> 00:22:21,650 +inheritedطبعاً معظم الحالات دي هنلاقي فيها target + +304 +00:22:21,650 --> 00:22:25,750 +cells من الأمثلة اللي هي beta chain amino acid + +305 +00:22:25,750 --> 00:22:29,190 +substitution بتطلع عندنا variant hemoglobin يعني + +306 +00:22:29,190 --> 00:22:32,150 +بيصير عندنا خلل في ال beta chain ده بيصير استبدال + +307 +00:22:32,150 --> 00:22:36,510 +amino acid ب amino acid تاني من الأمثلة اللي هو + +308 +00:22:36,510 --> 00:22:40,110 +hemoglobin S و hemoglobin C hemoglobin S بيصير + +309 +00:22:40,110 --> 00:22:40,790 +substitution + +310 +00:22:43,840 --> 00:22:47,460 +للـ Glutamic Acid بالـ Valine بينما Hemoglobin C + +311 +00:22:47,460 --> 00:22:52,460 +لـ Glutamic Acid بيصيرله Substitution بالـ Lysine + +312 +00:22:52,460 --> 00:22:54,880 +فبنشأ عندي نوعين من الـ Hemoglobin الـ Abnormal + +313 +00:22:54,880 --> 00:23:01,140 +Hemoglobin S و Hemoglobin C يبنيج + +314 +00:23:01,140 --> 00:23:03,860 +لـ Hemoglobin S أو Sickle Cell Anemia طبعاً أنتوا + +315 +00:23:03,860 --> 00:23:07,280 +عارفينها الـ Sickle Cell Anemia في عندي Two S-Gene + +316 +00:23:07,280 --> 00:23:13,660 +ممكن يكون واحد فيهم affected وممكن اتنانطبعاً + +317 +00:23:13,660 --> 00:23:17,140 +فبتكون Sickle Cell Anemia أو Sickle Cell Atrait + +318 +00:23:17,140 --> 00:23:23,160 +هنا بقولك هذه الحالة بتكون Asymptomatic بعد 6 شهور + +319 +00:23:23,160 --> 00:23:27,400 +ممكن تبدأ ال symptoms تظهر عليهم ليش Asymptomatic؟ + +320 +00:23:27,400 --> 00:23:30,740 +لأن الطفل في هذه الفترة بيكون عنده ال Hemoglobin F + +321 +00:23:30,740 --> 00:23:35,460 +مرتفع و ال Hemoglobin F مافي Beta-Chamفيه Gamma + +322 +00:23:35,460 --> 00:23:38,760 +Chain فبالتالي ما راح يبين عنده الخلال غير لما + +323 +00:23:38,760 --> 00:23:42,860 +يبدأ Hemoglobin F ينزل ويرفع Hemoglobin A طبعا + +324 +00:23:42,860 --> 00:23:45,580 +Hemoglobin A مش هيتكون بشكل كامل لأن الـ Beta + +325 +00:23:45,580 --> 00:23:49,280 +Chain اللي في Hemoglobin A affected فهذا راح يؤدي + +326 +00:23:49,280 --> 00:23:54,020 +لإنه هيبدأ يتكون عنده الـ Sickle Cell بعد 6 شهور و + +327 +00:23:54,020 --> 00:23:58,380 +تبدأ تظهر عنده الأعراض ليش؟ لأنه صار يتكون عنده + +328 +00:23:58,380 --> 00:24:02,980 +Hemoglobin Sطبعاً زي ما قلنا المشكلة بتكون إذا كان + +329 +00:24:02,980 --> 00:24:06,920 +SS يعني two genes affected لكن لو كان واحد + +330 +00:24:06,920 --> 00:24:11,040 +affected تبقى عندهم يعني مابيبقاش عندهم أعراض إلا + +331 +00:24:11,040 --> 00:24:15,080 +إذا يعني اتعرضوا لظروف حادة من نقص الأكسجين ممكن + +332 +00:24:15,080 --> 00:24:18,800 +يظهر عندهم mild problem فدول الناس اللي عندهم + +333 +00:24:18,800 --> 00:24:23,220 +trait طبعا يعني بس من رعيهم في ال .. في ال .. يعني + +334 +00:24:23,220 --> 00:24:26,000 +مثلا في الطيران في الصعود إلى الأماكن المرتفعة + +335 +00:24:26,000 --> 00:24:31,370 +لازم يبقى في تزويد لهم بالأكسجين وبالتاليبيعيشوا + +336 +00:24:31,370 --> 00:24:33,890 +حياتهم طبيعي ماعندهم مشاكل المشكلة عند مين عنده + +337 +00:24:33,890 --> 00:24:38,510 +الـ Sickle Cell Anemia هدول هلاقي عندهم Severe + +338 +00:24:38,510 --> 00:24:42,810 +Anemia هلاقي عندهم Target Cells هلاقي عندهم Sickle + +339 +00:24:42,810 --> 00:24:46,250 +Cells هي الـ Target Cell وهي Sickle Cell اللي هي + +340 +00:24:46,250 --> 00:24:49,350 +شكلين زي ما قلنا Filamentous Form and Wood Form + +341 +00:24:49,350 --> 00:24:53,030 +هنلاقي هذا في حالة الـ Sickling هنلاقي عندهم + +342 +00:24:53,030 --> 00:24:58,170 +Nucleated RBCs ليش؟ لأنه الـ Vulnerable Active + +343 +00:24:58,460 --> 00:25:02,100 +هيصير يطلع عندى nucleated RBCs وreticulocyte بشكل + +344 +00:25:02,100 --> 00:25:06,680 +كبير هدول طبعا حلاقة عندهم Hemoglobin A مش موجود + +345 +00:25:06,680 --> 00:25:09,800 +خالص لأن Hemoglobin A شرط في تكوين وجود الـ Beta + +346 +00:25:09,800 --> 00:25:13,520 +-Chain هدول ماعندهم الـ Beta-Chain وإنما حلاقة + +347 +00:25:13,520 --> 00:25:17,880 +عندهم تقريبا من 80 إلى 100% Hemoglobin S مع ارتفاع + +348 +00:25:17,880 --> 00:25:20,540 +في أنواع الـHemoglobin الأخرى اللي مافيها الـBeta + +349 +00:25:20,540 --> 00:25:26,820 +-Chain زي Hemoglobin F هاي + +350 +00:25:26,820 --> 00:25:31,610 +بقولك عن الـTraitهنا جين واحد اللي affected عادة + +351 +00:25:31,610 --> 00:25:34,430 +asymptomatic ممكن أشوف في بعض الأحيان عندهم target + +352 +00:25:34,430 --> 00:25:37,910 +cells نوع anemia or sickle cell عندهم Hemoglobin A + +353 +00:25:37,910 --> 00:25:43,570 +بشكل تقريبا 60% و40% Hemoglobin S طبعا potential + +354 +00:25:43,570 --> 00:25:47,950 +problems of hypoxia يعني ممكن يتعرضوا لبعض المشاكل + +355 +00:25:47,950 --> 00:25:55,810 +في ظروف الhypoxia بس نيجي + +356 +00:25:55,810 --> 00:26:01,340 +لل Hemoglobin C diseaseطبعاً هنا هنلاقي الـ two + +357 +00:26:01,340 --> 00:26:05,180 +genes two beta chain affected وتم استبدال الـ beta + +358 +00:26:05,180 --> 00:26:08,620 +chain تم استبدال الـ glutamic acid فيهم بالليسين + +359 +00:26:08,620 --> 00:26:12,840 +فبنتج عندي Hemoglobin C طبعاً Hemoglobin C هيعمل + +360 +00:26:12,840 --> 00:26:16,000 +crystallization في داخل الخلية ويظهر كblock زي ما + +361 +00:26:16,000 --> 00:26:18,800 +أنتوا شايفين هذا هو في داخل الخلية الـ Hemoglobin + +362 +00:26:18,800 --> 00:26:22,500 +C crystals بنتج عنه mild anemia target cells + +363 +00:26:22,500 --> 00:26:26,880 +intracellular Hemoglobin C Hemoglobin A مش هتلاقي + +364 +00:26:26,880 --> 00:26:33,400 +Hemoglobin Aأكتر من 90% هتلاقي Hemoglobin-C الحالة + +365 +00:26:33,400 --> 00:26:38,260 +التانية أنه يبقى one beta chain affected one gene + +366 +00:26:38,260 --> 00:26:41,820 +في + +367 +00:26:41,820 --> 00:26:45,520 +تعوين الـ beta chain يعطيني Hemoglobin-C هنا + +368 +00:26:45,520 --> 00:26:49,640 +هتلاقيها asymptomatic with no anemia ممكن ألاقي + +369 +00:26:49,640 --> 00:26:53,760 +target cells مش هشوف Hemoglobin-C crystalsحلائق من + +370 +00:26:53,760 --> 00:27:00,120 +تقريبا 60% Hemoglobin-A و40% Hemoglobin-C برضه هنا + +371 +00:27:00,120 --> 00:27:03,160 +حلائق الـ Hemoglobin-A تو Normal و Hemoglobin-F + +372 +00:27:03,160 --> 00:27:07,800 +هيكون برضه Normal نجي + +373 +00:27:07,800 --> 00:27:12,700 +للـ Hemoglobin-S-C Disease هنا بيبقى في عنده الـ + +374 +00:27:12,700 --> 00:27:16,700 +two beta chain affected واحدة فيهم تعطيني + +375 +00:27:16,700 --> 00:27:20,480 +Hemoglobin-S يعني صار فيها substitution مختلفة عن + +376 +00:27:20,480 --> 00:27:28,060 +التانيةالتانية بتعطيني Hemoglobin C طيب هنا هاي + +377 +00:27:28,060 --> 00:27:31,580 +هنا هذا شرح للحالة double heterozygous inherit + +378 +00:27:31,580 --> 00:27:36,280 +sickle gene from one parent and C gene from other + +379 +00:27:36,280 --> 00:27:41,500 +parent both beta chain are abnormal ال lab finding + +380 +00:27:41,500 --> 00:27:44,700 +intermediate in severity هتلاقي ال severity بتاعة + +381 +00:27:44,700 --> 00:27:48,020 +الحالة متوسطة ما بين ال sickle cell أنميا و sickle + +382 +00:27:48,020 --> 00:27:48,600 +cell trait + +383 +00:27:51,930 --> 00:27:57,430 +هنلاقي فيه Target Cells هنلاقي SC Crystals مش + +384 +00:27:57,430 --> 00:28:04,330 +هتلاقي Hemoglobin A هتلاقي 50% Hemoglobin S و 50% + +385 +00:28:04,330 --> 00:28:08,370 +Hemoglobin C نيجي + +386 +00:28:08,370 --> 00:28:13,310 +للـ Acquired Hemolytic Anemia النوع التاني + +387 +00:28:13,310 --> 00:28:16,370 +Acquired Hemolytic Anemia طبعا هنا الخلية بتتكون + +388 +00:28:16,370 --> 00:28:20,580 +صح مش فيها ولا غلطةلكن ظروف خارجية بتأثر على + +389 +00:28:20,580 --> 00:28:23,740 +الخلية بصيرها تكسير زي الـ Immune-mediated + +390 +00:28:23,740 --> 00:28:27,180 +destruction Red Cell Fragmentation Disorder + +391 +00:28:27,180 --> 00:28:32,660 +Acquired Membrane Defects Spleen Defects هذه مشاكل + +392 +00:28:32,660 --> 00:28:38,420 +بتأثر على الخلية و بتقليها تتكسر طبعا هذه الأسباب + +393 +00:28:38,420 --> 00:28:42,500 +يعني ممكن يكون إيش سببها ممكن يكون Immune + +394 +00:28:42,500 --> 00:28:47,390 +Hemolytic Anemia قد تكون Warm أو ColdWarm + +395 +00:28:47,390 --> 00:28:51,330 +Autoimmune Hemolytic Anemia هنا المشكلة أنه بتكون + +396 +00:28:51,330 --> 00:28:55,570 +للـ Self-antigen Auto-antibodies وعادة بتكون Warm + +397 +00:28:55,570 --> 00:29:01,670 +Antibodies من النوع IgG طبعاً هترتبط مع الخلية أو + +398 +00:29:01,670 --> 00:29:04,490 +تعمل sensitization للخلية ممكن يصير complement + +399 +00:29:04,490 --> 00:29:10,310 +activation أو sensitization فهتروح هذه الخلية على + +400 +00:29:10,310 --> 00:29:14,890 +الـSpleen الـSpleen فيها الفاجوسيتس هتعمل لها + +401 +00:29:15,390 --> 00:29:19,050 +Partial Phagocytosis يعني هتعمل بيت لل .. اللي هو + +402 +00:29:19,050 --> 00:29:21,530 +الـ Antibody اللي عانى ال sensitization للخلية + +403 +00:29:21,530 --> 00:29:26,170 +بيصير عندى خلية Spherocyte طبعا بعد هيك هيصير عندى + +404 +00:29:26,170 --> 00:29:31,410 +license لهذه الخلايا قد يكون السبب idiopathic او + +405 +00:29:31,410 --> 00:29:33,950 +secondary نتيجة disease اخر يعني ممكن يكون ال + +406 +00:29:33,950 --> 00:29:37,270 +primary انه فيه auto antibodies بس يعني مش معروف + +407 +00:29:37,270 --> 00:29:40,690 +ايش السبب ممكن يكون نتيجة مرض اخر يزول بزوال + +408 +00:29:40,690 --> 00:29:43,510 +المؤثر هي شكل ال blood film فيه عدد من ال + +409 +00:29:43,510 --> 00:29:48,630 +Spherocyteموجودة في الخلية شايفين كيف؟ ممكن أشوف + +410 +00:29:48,630 --> 00:29:53,290 +فيها abnormality ممكن أشوف polyachromagia ال + +411 +00:29:53,290 --> 00:29:56,330 +polyachromagia دي إيش قولنا عنها؟ هي ال + +412 +00:29:56,330 --> 00:30:02,710 +reticulocyte ال immature erythrocyte طيب ال lab + +413 +00:30:02,710 --> 00:30:06,670 +finding هنلاقي حسب طبعا الحالة moderate to severe + +414 +00:30:06,670 --> 00:30:11,400 +anemiaممكن أشوف الـ Spherocytes ممكن أشوف ال .. + +415 +00:30:11,400 --> 00:30:15,720 +طبعا وين في Spherocyte حاجة الـ MCHC مرتفعة ممكن + +416 +00:30:15,720 --> 00:30:19,340 +أشوف شكل اللي هو الـ Erythropagocytosis يعني أشوف + +417 +00:30:19,340 --> 00:30:23,580 +Erythrocyte صير لها Phagocytosis ليش؟ لأنه هذه الـ + +418 +00:30:23,580 --> 00:30:27,100 +Erythrocyte تحسست بالـ Antibody فبالتالي هتيجي ال + +419 +00:30:27,100 --> 00:30:30,120 +Phagocyte تعمل لها Phagocyte يعني هنا هي عنا واضح + +420 +00:30:30,120 --> 00:30:32,840 +Monocyte عاملة Phagocytosis ل Erythrocyte + +421 +00:30:38,420 --> 00:30:41,480 +طبعاً الـ Blood Film تبعها بشبه الـ Hereditary + +422 +00:30:41,480 --> 00:30:45,520 +Spherocytosis لكن فيه فرق إن الـ Direct + +423 +00:30:45,520 --> 00:30:48,760 +Antiglobulin Test فيها بيكون Positive أو إله اسم + +424 +00:30:48,760 --> 00:30:51,780 +تاني اللي هو الـ Combs Test فده كتير مهم في + +425 +00:30:51,780 --> 00:30:56,620 +التمييز بين أنواع الـ Hemolytic Anemia إذا كان الـ + +426 +00:30:56,620 --> 00:31:00,320 +Combs Test Positive أو ده الـ Test اسمه Positive + +427 +00:31:00,320 --> 00:31:04,370 +هناخد نبذة عنه إن شاء الله في معمل المناعةإذا كان + +428 +00:31:04,370 --> 00:31:07,750 +هذا الفحص positive معنى الكلام إنه هذه autoimmune + +429 +00:31:07,750 --> 00:31:11,750 +hemolytic anemia إيش هو هذا الـDAT أو الكومس بيكشف + +430 +00:31:11,750 --> 00:31:14,910 +عن وجود sensitized cells بيكشف عن وجود خلايا + +431 +00:31:14,910 --> 00:31:21,170 +متحسسة نتيجة أفاعل مناعي طبعا الخلايا لأنها صارت + +432 +00:31:21,170 --> 00:31:24,750 +spherocyte هنلاقي ال osmotic fragility ارتفعت + +433 +00:31:24,750 --> 00:31:29,110 +طالما زادت تكسير هتلاقي ال bilirubin برضه ارتفع + +434 +00:31:29,110 --> 00:31:32,670 +أضف لإنه هتلاقي erythroid hyperplasia + +435 +00:31:36,110 --> 00:31:39,730 +نيجي إلى الـ Cold Autoimmune Hemolytic Anemia هنا + +436 +00:31:39,730 --> 00:31:43,810 +يا بنات، في عندى Antibodies للخلايا لكن هاد الـ + +437 +00:31:43,810 --> 00:31:48,310 +Antibodies من نوع IgM و بتتميز بإنها Cold بمعنى + +438 +00:31:48,310 --> 00:31:52,270 +إنه يعني عادة ما بتشتغل على ال body temperature + +439 +00:31:52,270 --> 00:31:59,370 +لكن ممكن تشتغل على ال room temperature يعني في هذه + +440 +00:31:59,370 --> 00:32:02,310 +الحلقة لو أنا أجيت سحبت عينة تراكتها شوية حتى + +441 +00:32:02,310 --> 00:32:05,150 +أتلاقي العينة عملت Autoagglutination لكن في بعض + +442 +00:32:05,150 --> 00:32:08,080 +الأحيانهتلاقي الـ antibody أو الـ complement + +443 +00:32:08,080 --> 00:32:12,040 +component ارتبطت على سطح الخلايا وعملت complement + +444 +00:32:12,040 --> 00:32:15,720 +activation وحيصير agglutination and lyses by + +445 +00:32:15,720 --> 00:32:20,180 +complement or macrophage ممكن تكون primary أو + +446 +00:32:20,180 --> 00:32:22,060 +secondary لديزييز معين + +447 +00:32:24,660 --> 00:32:29,080 +الـ Lab finding هنلاقي agglutination للـ RBC في + +448 +00:32:29,080 --> 00:32:32,860 +الأطراف زي الأماكن الباردة اللي ممكن تتعرض لدرجة + +449 +00:32:32,860 --> 00:32:38,360 +حرارة باردة زي الأذن الأصابع الأنف هذا طبعا راح + +450 +00:32:38,360 --> 00:32:42,400 +يؤدي إلى tissue damage ممكن يؤدي إلى مضاعفات خطيرة + +451 +00:32:42,400 --> 00:32:47,250 +زي الـ necrosis والجانجرينSeverity varies with + +452 +00:32:47,250 --> 00:32:52,150 +seasons Avoid the cold يعني حدة المرض بتعتمد على + +453 +00:32:52,150 --> 00:32:56,430 +الجو فبالتالي بتزيد في الأجواء الباردة ليش؟ لأن + +454 +00:32:56,430 --> 00:33:00,050 +الـ IGM بارد مش تغير درجة الحرارة الباردة IGM + +455 +00:33:00,050 --> 00:33:03,410 +antibodies causes RBCs agglutination هنشوف + +456 +00:33:03,410 --> 00:33:05,790 +agglutination واضحة للـ blood film لو أنا عملت + +457 +00:33:05,790 --> 00:33:09,270 +blood film هنلاقي reticulocytosis كرد فعلي تكسير + +458 +00:33:09,270 --> 00:33:13,490 +الخلايا بصير تنشيط للـ bone marrowهنلاقي positive + +459 +00:33:13,490 --> 00:33:17,530 +data test detect complement طبعا يا بنات بشكل أساس + +460 +00:33:17,530 --> 00:33:19,970 +الـ IGM هو اللي بعمل activation للـ complement + +461 +00:33:19,970 --> 00:33:23,870 +فبالتالي الـ complement لما بتتنشط ممكن تعمل + +462 +00:33:23,870 --> 00:33:27,010 +sensitization للخلايا فبالتالي بكشف عنها بالـ + +463 +00:33:27,010 --> 00:33:29,830 +direct antoglobulin test أو بالـ Combs test إذا + +464 +00:33:29,830 --> 00:33:33,590 +كنتوا فاكرين توي قلتلكم الـ Combs test بعمل كشف لل + +465 +00:33:33,590 --> 00:33:37,910 +sensitization بالـ antibody وبرضه بعمل كشف لل + +466 +00:33:37,910 --> 00:33:41,290 +sensitization بالـ Combs testبالـ .. بالـ عفو بالـ + +467 +00:33:41,290 --> 00:33:44,110 +complement هلاقيت إذا صار الـ sensitization بالـ + +468 +00:33:44,110 --> 00:33:47,070 +complement بفهم إنه هذا ال antibody IgM لأن هو + +469 +00:33:47,070 --> 00:33:50,190 +اللي بعمل أغلبا activation لل complement إذا صار + +470 +00:33:50,190 --> 00:33:53,410 +ال sensitization ب antibody فبفهم إنه IgG + +471 +00:34:09,500 --> 00:34:17,740 +هنا أنا طبعا بروح بنقل وحة الدم وحة الدم هذه هيكون + +472 +00:34:17,740 --> 00:34:23,840 +فيها بعض الـ Antigens الـ Antigens هذه لن تتوافق + +473 +00:34:23,840 --> 00:34:26,720 +مع ال patient يعني ال patient عنده antibodies لها + +474 +00:34:26,720 --> 00:34:31,200 +يعني ال recipient عنده antibody X ونقلتله Antigen + +475 +00:34:31,200 --> 00:34:35,920 +X هيصير أكيد reaction وبالتالي هيصير تكسير لخلايا + +476 +00:34:35,920 --> 00:34:40,050 +ال donorأسوأ واحد فيهم اللي هو الـ ABO + +477 +00:34:40,050 --> 00:34:43,730 +Incompatibility طبعا أنتوا ما بتعرفوش غيره في عندي + +478 +00:34:43,730 --> 00:34:46,450 +أنواع تانية من الـ Incompatibility هتاخدوها في بنك + +479 +00:34:46,450 --> 00:34:51,510 +الذمب لكن بنحكي أكثر واحد بيعمل مشاكل اللي هو الـ + +480 +00:34:51,510 --> 00:34:55,210 +ABO Blood Group System بيعمل Intravascular + +481 +00:34:55,210 --> 00:35:00,730 +Hemolysis ليش؟ لأن هنا ال reaction بيكون strong + +482 +00:35:01,160 --> 00:35:04,080 +والـ Antibody is strong فبتعمل Intravascular + +483 +00:35:04,080 --> 00:35:07,140 +Hemolysis نتيجة الـ Complement Activation يعني ما + +484 +00:35:07,140 --> 00:35:10,120 +بيستنى الـ Antibody يعمل Synthetization ويروح + +485 +00:35:10,120 --> 00:35:14,260 +هالسبلين لسه و هناك يصير له تكسير زي الـ IgG ثم + +486 +00:35:14,260 --> 00:35:18,260 +مباشرة هيصير له تكسير في الـ Peripheral Blood فيما + +487 +00:35:18,260 --> 00:35:21,500 +يسمى الـ Intravascular Hemolysis طبعا ممكن يعمل + +488 +00:35:21,500 --> 00:35:25,180 +بلوك للنفرون للمصافر الكدنى الـ Antigen Antibody + +489 +00:35:25,180 --> 00:35:28,300 +Complexes وممكن يكون Alive with Retaining + +490 +00:35:32,370 --> 00:35:37,870 +نيجي للـHemolytic Disease of the newborn طبعاً هذه + +491 +00:35:37,870 --> 00:35:42,190 +بنات يعني أنا دائما بذكركم فيه اللي هو عامل Rhesus + +492 +00:35:42,190 --> 00:35:46,490 +إذا كان فيش توافق بين فصيلة الأم والطفل إيش ممكن + +493 +00:35:46,490 --> 00:35:52,450 +يصير؟ ممكن عند قطع الحبل السري تنتقل بعض الخلايا + +494 +00:35:52,450 --> 00:35:57,330 +اللي قد تعتبر فيها Antigens غريبة إلى الأم احنا + +495 +00:35:57,330 --> 00:36:03,830 +دايما المثال الشائع عندنااللي هو الـ Rh صح؟ هو في + +496 +00:36:03,830 --> 00:36:08,150 +أشياء تانية لكن الأكتر شيوعا الـ Rh هلاقيت عند قطع + +497 +00:36:08,150 --> 00:36:11,530 +الحبل السري إذا كان الطفل موجب و الأم negative + +498 +00:36:11,530 --> 00:36:17,210 +هتنتقل خلايا موجبة إلى الأم وبالتالي هتعتبر خلايا + +499 +00:36:17,210 --> 00:36:21,570 +غريبة فهيتكونلها antibodies فلاقيت الأم اتكون + +500 +00:36:21,570 --> 00:36:26,810 +عندها anti نقول مجازن Anti-D عن الـ Rh لأن الـ Rh + +501 +00:36:26,810 --> 00:36:30,640 +مجموعة من الانتجنات أهم واحد فيهم الـ Dفالأم حيصير + +502 +00:36:30,640 --> 00:36:33,900 +عندها Anti-D فلاقيت الـ Anti-D هذا مش هيأذى الطفل + +503 +00:36:33,900 --> 00:36:36,700 +الأول لكن لو حملة مرة تانية بطفل عنده الـ D + +504 +00:36:36,700 --> 00:36:40,600 +-Antigen أو الـ Rh Positive هينتقل الـ Anti-D + +505 +00:36:40,600 --> 00:36:46,280 +للطفل ويعمل تكسير للخلايا تبعته فهينشق Hemolytic + +506 +00:36:46,280 --> 00:36:50,340 +Disease of a Newborn وبتتميز ذات الـ Rh بأنها + +507 +00:36:50,340 --> 00:36:55,320 +بتعمل Severe Anemia وحنلاقي فيها Nucleated R + +508 +00:36:55,320 --> 00:36:59,770 +-Pieces تمام؟طبعاً أنتوا عارفين إيش علاجها إنه + +509 +00:36:59,770 --> 00:37:04,870 +إحنا بنعطي الأم بمجرد ما تولد اللي هو إبرة إيش + +510 +00:37:04,870 --> 00:37:11,990 +الإبرة هذه؟ هي عبارة عن Anti-D جاهز بحيث إنه أي + +511 +00:37:11,990 --> 00:37:15,790 +خلية أي خلية تمرق من الطفل للأم تم تكسيرها مباشرة + +512 +00:37:15,790 --> 00:37:20,250 +قبل ما يتكونلها antibodies طيب + +513 +00:37:20,250 --> 00:37:24,310 +الـHemolytic Disease due to ABO incompatibility + +514 +00:37:24,310 --> 00:37:27,690 +يعنيفي عندنا Hemolytic Disease بس مش نتيجة الـ RH + +515 +00:37:27,690 --> 00:37:34,090 +نتيجة الـ ABO هذه أمتى بتصير؟ بتصير إذا كانت الأم + +516 +00:37:34,090 --> 00:37:38,590 +فصلتها O إذا كانت الأم طبعا مش دايما هذه يعني مش + +517 +00:37:38,590 --> 00:37:43,450 +شائعة الحدوث إذا كانت الأم فصلتها O هيكون عندها + +518 +00:37:43,450 --> 00:37:49,550 +Anti-A و Anti-B و هدول Anti-A و Anti-B ممكن فيهم + +519 +00:37:49,550 --> 00:37:52,370 +IgG ممكن يخترقوا الـ placenta يعني ممكن يخترقوا + +520 +00:37:52,370 --> 00:37:56,080 +المشيمة أو يوصلوا للطفلففرضًا كان الطفل فصيلته A + +521 +00:37:56,080 --> 00:38:00,580 +أو B ووصله من الأم Anti-A أو Anti-B ممكن يصير عنده + +522 +00:38:00,580 --> 00:38:04,020 +Mild Hemolysis بس ما بتطور لأنميا وبنشوف عنده + +523 +00:38:04,020 --> 00:38:08,700 +Serocytes هذا مش كتير common لأن الـ Rh أنتجنز + +524 +00:38:08,700 --> 00:38:12,480 +عفوا الـ ABO أنتجنز نفسها ما بتكونش لسه مكتملة + +525 +00:38:12,480 --> 00:38:15,780 +بشكل كافي عند الطفل انها تعمل reaction على خلاف + +526 +00:38:15,780 --> 00:38:17,760 +الـ Rh اللي هو الأكثر شيء عندي + +527 +00:38:21,550 --> 00:38:26,190 +نجي للـ Hemolytic Anemia due to trauma طبعا أنه + +528 +00:38:26,190 --> 00:38:29,990 +Hemolytic Anemia ساقنة يعني صار تعرض لـ External + +529 +00:38:29,990 --> 00:38:35,390 +trauma أفرت على الخلايا فعملت لها تكسير + +530 +00:38:35,390 --> 00:38:41,390 +Fragmentation Syndrome ممكن تكون mechanical زي + +531 +00:38:41,390 --> 00:38:45,970 +الناس اللي هي بتركب صممات قلب صناعية مرور الخلايا + +532 +00:38:45,970 --> 00:38:50,180 +عبر الصمام هذا ممكن يعمل فيها damageأو حالة + +533 +00:38:50,180 --> 00:38:53,620 +بيسموها microangiopathic microangiopathic تبقى ال + +534 +00:38:53,620 --> 00:39:00,460 +blood vessels اكتر دقيقة دقيقة جدا طبعا هذه ممكن + +535 +00:39:00,460 --> 00:39:04,900 +يصير تكثير للخلايا وممكن تتطور لحالات DIC و + +536 +00:39:04,900 --> 00:39:07,760 +bleeding disseminated intravascular coagulation + +537 +00:39:08,750 --> 00:39:13,750 +مارش مغلوبينيوريا طبعا هذه تيجي للعدائين اللي + +538 +00:39:13,750 --> 00:39:16,890 +بيجروا مسافات طويلة ممكن يصير عندهم تكسير في ال + +539 +00:39:16,890 --> 00:39:21,030 +blood نتيجة الحركة السريعة والاحتكاك المفاصل طبعا + +540 +00:39:21,030 --> 00:39:26,450 +هذه طبعا بتزول بزوال المؤثر ممكن نشوف فيها + +541 +00:39:26,450 --> 00:39:31,830 +مغلوبينيوريا نيجي + +542 +00:39:31,830 --> 00:39:35,830 +لل hemolytic anemia اللي شاية من infectious agents + +543 +00:39:35,830 --> 00:39:41,440 +and bearsطبعا هنا الانيميا يعني بعض الأشياء اللي + +544 +00:39:41,440 --> 00:39:45,180 +ممكن تعمل infection بعض ال agent ممكن تعمل عندي + +545 +00:39:45,180 --> 00:39:51,560 +انيميا أو تكثير بال RBC أو واحد تعرض لحروق أو تعرض + +546 +00:39:51,560 --> 00:39:56,020 +لحروق طبعا هنا الانيميا حسب الشدة بتكون حسب المؤثر + +547 +00:39:56,020 --> 00:39:59,340 +اللي تعرضله هذا الشخص هي ممكن ألاقي Schistocyte أو + +548 +00:39:59,340 --> 00:40:04,960 +Spherocyte في blood smearعنا من الأمثلة بعض + +549 +00:40:04,960 --> 00:40:08,720 +البروسايتز زي الملاريا البروسايتز هذه هتعطيني + +550 +00:40:08,720 --> 00:40:12,400 +lightening toxin ممكن تعمل license لل RBCs أو + +551 +00:40:12,400 --> 00:40:14,900 +cause direct damage to red cell membrane هلأ هي + +552 +00:40:14,900 --> 00:40:20,200 +خلال فترة التكاثر تبعتها الملاريا أنه بتتكاثر في + +553 +00:40:20,200 --> 00:40:23,100 +داخل الارترسايت و بعدين بيصير license لل RBCs عشان + +554 +00:40:23,100 --> 00:40:26,720 +ينطلق هذا يطلع هذا البروسايتز اللي اتكاثر في قلب + +555 +00:40:26,720 --> 00:40:29,810 +الارترسايتزفإما عن طريق الـ «توكسين» اللي بتفرزها + +556 +00:40:29,810 --> 00:40:34,990 +أو عن طريق التكسيق أو الـ «license» المباشر للـ + +557 +00:40:34,990 --> 00:40:38,270 +Cell Membrane إيه في حالات الـ Clostridium برضه + +558 +00:40:38,270 --> 00:40:40,670 +اللي بتعمل «توكسين»؟ حلائق «شيستوسايت» وحلائق + +559 +00:40:40,670 --> 00:40:46,010 +«سبيروسايتروز» هيك + +560 +00:40:46,010 --> 00:40:50,530 +نكون خلصنا الأنميا يعطيكوا ألف عافية بعد هيك راح + +561 +00:40:50,530 --> 00:40:55,070 +ننتقل لمرحلة تانية في الأنميا اللي هي أنا بعتبرها + +562 +00:40:55,070 --> 00:40:58,250 +الأهموهي مرحلة الـ Case Studies + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_raw.json b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..52e06f86ecf12a89877e17be89276e0e1a38f698 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 3131, "start": 1.69, "end": 31.31, "text": "الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم الدم التشخيصي diagnostic hematology زي ما اتكلمنا مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن أمراض الدم تقريبا", "tokens": [6027, 43761, 9154, 25124, 1829, 9566, 7649, 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{"start": 603.02, "end": 603.24, "word": " هيك", "probability": 0.9462890625}, {"start": 603.24, "end": 603.82, "word": " بتتأثر", "probability": 0.743438720703125}, {"start": 603.82, "end": 604.8, "word": " في", "probability": 0.880859375}, {"start": 604.8, "end": 605.02, "word": " الـ", "probability": 0.779541015625}, {"start": 605.02, "end": 605.68, "word": " Extravascular", "probability": 0.76513671875}, {"start": 605.68, "end": 606.24, "word": " Hemolysis", "probability": 0.8133138020833334}, {"start": 606.24, "end": 606.54, "word": " هذا", "probability": 0.87255859375}, {"start": 606.54, "end": 606.68, "word": " اللي", "probability": 0.98974609375}, {"start": 606.68, "end": 607.28, "word": " بيصير", "probability": 0.986572265625}, {"start": 607.28, "end": 608.74, "word": " بس", "probability": 0.972412109375}, {"start": 608.74, "end": 609.36, "word": " بوتيرة", "probability": 0.8551432291666666}, {"start": 609.36, "end": 609.84, "word": " عالية", "probability": 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كلها", "probability": 0.65966796875}, {"start": 635.58, "end": 637.1, "word": " هنلاقيها", "probability": 0.9138671875}, {"start": 637.1, "end": 638.02, "word": " انها", "probability": 0.445068359375}, {"start": 638.02, "end": 638.58, "word": " ارتفعت", "probability": 0.9630126953125}, {"start": 638.58, "end": 640.12, "word": " هذا", "probability": 0.74658203125}, {"start": 640.12, "end": 640.4, "word": " إذن", "probability": 0.5978190104166666}, {"start": 640.4, "end": 640.7, "word": " وان", "probability": 0.65869140625}, {"start": 640.7, "end": 641.28, "word": " في", "probability": 0.62646484375}, {"start": 641.28, "end": 641.44, "word": " الـ", "probability": 0.90185546875}, {"start": 641.44, "end": 642.26, "word": " Extravascular", "probability": 0.7202962239583334}, {"start": 642.26, "end": 642.94, "word": " Hemolysis", "probability": 0.81884765625}], "temperature": 1.0}, {"id": 24, "seek": 67555, "start": 646.97, "end": 675.55, "text": "الـ Intravascular Hemolysis هنا بيصير التكسير في داخل الـ blood vessels بيصير في داخل الـ blood vessels والهيموجلوبين هذا عادة عادة ممكن يصير نتيجة complement activation يعني ممكن يكون نتيجة immune hemolysis وتحفيز للـ complement فما يعني ما بيروح الـ radiculoendothelial system بتكسر في داخل الـ circulation", "tokens": [6027, 39184, 5681, 13404, 22084, 18568, 16453, 17122, 34105, 4724, 1829, 9381, 13546, 16712, 4117, 3794, 13546, 8978, 11778, 47283, 1211, 2423, 39184, 3390, 20117, 4724, 1829, 9381, 13546, 8978, 11778, 47283, 1211, 2423, 39184, 3390, 20117, 16070, 3224, 32640, 29245, 1211, 37746, 9957, 23758, 6225, 18513, 3660, 6225, 18513, 3660, 3714, 43020, 7251, 9381, 13546, 8717, 31371, 7435, 3660, 17103, 24433, 37495, 22653, 3714, 43020, 7251, 30544, 8717, 31371, 7435, 3660, 11992, 415, 3280, 356, 17122, 34683, 5016, 41185, 11622, 24976, 39184, 17103, 6156, 15042, 37495, 22653, 19446, 4724, 13546, 2407, 5016, 2423, 39184, 2843, 299, 13455, 521, 900, 338, 831, 1185, 39894, 4117, 3794, 2288, 8978, 11778, 47283, 1211, 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"word": " complement", "probability": 0.86767578125}, {"start": 671.09, "end": 671.69, "word": " فما", "probability": 0.703125}, {"start": 671.69, "end": 672.09, "word": " يعني", "probability": 0.6634521484375}, {"start": 672.09, "end": 672.23, "word": " ما", "probability": 0.92529296875}, {"start": 672.23, "end": 672.53, "word": " بيروح", "probability": 0.8543701171875}, {"start": 672.53, "end": 672.75, "word": " الـ", "probability": 0.492431640625}, {"start": 672.75, "end": 673.67, "word": " radiculoendothelial", "probability": 0.7071707589285714}, {"start": 673.67, "end": 673.99, "word": " system", "probability": 0.94970703125}, {"start": 673.99, "end": 674.51, "word": " بتكسر", "probability": 0.846923828125}, {"start": 674.51, "end": 674.67, "word": " في", "probability": 0.9521484375}, {"start": 674.67, "end": 675.01, "word": " داخل", "probability": 0.9695638020833334}, {"start": 675.01, "end": 675.23, "word": " الـ", "probability": 0.64453125}, {"start": 675.23, "end": 675.55, "word": " circulation", "probability": 0.9638671875}], "temperature": 1.0}, {"id": 25, "seek": 70408, "start": 676.42, "end": 704.08, "text": "هذا بنتج عنه وجود إكسرة الخلية هيطلع الـ Hemoglobin منها الأصل إن الـ Hemoglobin ما بيكون free في ال blood هنا حيصير في عندنا free Hemoglobin طبعا الـ free Hemoglobin بده ينتقل للـ liver كيف بينتقل عن طريق الـ Heptoglobin اللي هو البروتين ال carrier للـ Hemoglobin الـ Heptoglobin هنا هتنقص كميتو لأنه هيصير saturated أو منشغل و مرتبط بالـ Hemoglobin", "tokens": [3224, 15730, 44945, 2655, 7435, 18871, 3224, 49610, 23328, 11933, 4117, 3794, 25720, 33962, 1211, 10632, 39896, 9566, 1211, 3615, 2423, 39184, 18568, 45841, 13496, 9154, 11296, 16247, 36520, 36145, 2423, 39184, 18568, 45841, 13496, 19446, 4724, 1829, 30544, 1737, 8978, 2423, 3390, 34105, 11331, 1829, 9381, 13546, 8978, 43242, 8315, 1737, 18568, 45841, 13496, 23032, 3555, 3615, 995, 2423, 39184, 1737, 18568, 45841, 13496, 47525, 3224, 7251, 29399, 4587, 1211, 24976, 39184, 15019, 9122, 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{"start": 693.56, "end": 694.42, "word": " البروتين", "probability": 0.80352783203125}, {"start": 694.42, "end": 694.64, "word": " ال", "probability": 0.7587890625}, {"start": 694.64, "end": 695.04, "word": " carrier", "probability": 0.40673828125}, {"start": 695.04, "end": 695.9, "word": " للـ", "probability": 0.640625}, {"start": 695.9, "end": 696.54, "word": " Hemoglobin", "probability": 0.9230143229166666}, {"start": 696.54, "end": 697.46, "word": " الـ", "probability": 0.9521484375}, {"start": 697.46, "end": 698.12, "word": " Heptoglobin", "probability": 0.902587890625}, {"start": 698.12, "end": 698.46, "word": " هنا", "probability": 0.96044921875}, {"start": 698.46, "end": 699.18, "word": " هتنقص", "probability": 0.90908203125}, {"start": 699.18, "end": 699.64, "word": " كميتو", "probability": 0.8519287109375}, {"start": 699.64, "end": 699.96, "word": " لأنه", "probability": 0.8821614583333334}, {"start": 699.96, "end": 700.4, "word": " هيصير", "probability": 0.8304036458333334}, 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هذه عادة بتكون congenital ممكن تبين بداية عند الولادة أو ممكن خلال مراحل الحياة في بعضها بيضل silent يعني مافيش عليه مافيش ال patient عليه أي أعراض لغاية ما يتعرض لمؤثر يبين هذه المشكلة زي الـ G6PD ممكن طيب هذه إيش أسبابها أسبابها خلال", "tokens": [9566, 3555, 3615, 995, 34105, 29538, 6225, 18513, 3660, 39894, 30544, 416, 1766, 1686, 3714, 43020, 6055, 3555, 9957, 4724, 28259, 10632, 43242, 2423, 12610, 18513, 3660, 34051, 3714, 43020, 16490, 1211, 6027, 3714, 23557, 5016, 1211, 21542, 25528, 3660, 8978, 45030, 11242, 11296, 4724, 1829, 11242, 1211, 12784, 37495, 22653, 19446, 41185, 8592, 47356, 19446, 41185, 8592, 2423, 4537, 47356, 36632, 5551, 3615, 2288, 46958, 5296, 17082, 995, 10632, 19446, 7251, 2655, 3615, 43042, 32767, 33604, 49115, 7251, 3555, 9957, 29538, 9673, 8592, 28820, 3660, 30767, 1829, 2423, 39184, 460, 21, 17349, 3714, 43020, 23032, 1829, 3555, 29538, 11933, 1829, 8592, 5551, 35457, 16758, 11296, 5551, 35457, 16758, 11296, 16490, 1211, 6027], "avg_logprob": 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سايتوزز بتكون الخلية شكلها رفيعة زي ما أنتوا شايفين هنا ovalocyte شايفين كيف شكلها هنا هذا بيكون سببه أنه أصار polarization للكلسترال أو للهيموجلوبيين عند أطراف الخلية فأخدت هذا الشكل هنلاقي تقريبا 25% أو أكثر of ovalocytes عادة بتكون asymptomatic", "tokens": [1863, 10721, 31371, 24976, 39184, 14187, 10334, 1344, 83, 8211, 34051, 2423, 16758, 2655, 2407, 8608, 995, 36081, 2407, 11622, 11622, 39894, 30544, 33962, 1211, 10632, 13412, 28820, 11296, 12602, 5172, 40228, 3660, 30767, 1829, 19446, 14739, 2655, 14407, 13412, 995, 33911, 9957, 34105, 14187, 10334, 1344, 975, 13412, 995, 33911, 9957, 9122, 33911, 13412, 28820, 11296, 34105, 23758, 4724, 1829, 30544, 8608, 3555, 3555, 3224, 14739, 3224, 5551, 9381, 9640, 37736, 24976, 28820, 14851, 2288, 6027, 34051, 24976, 3224, 32640, 29245, 1211, 2407, 21292, 9957, 43242, 5551, 9566, 23557, 5172, 33962, 1211, 10632, 6156, 10721, 9778, 3215, 2655, 23758, 25124, 28820, 8032, 1863, 15040, 38436, 6055, 4587, 16572, 3555, 995, 3552, 4, 34051, 5551, 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"word": " بيكون", "probability": 0.9348958333333334}, {"start": 997.01, "end": 997.55, "word": " سببه", "probability": 0.9853515625}, {"start": 997.55, "end": 998.13, "word": " أنه", "probability": 0.677734375}, {"start": 998.13, "end": 998.49, "word": " أصار", "probability": 0.8502604166666666}, {"start": 998.49, "end": 998.99, "word": " polarization", "probability": 0.83251953125}, {"start": 998.99, "end": 1000.21, "word": " للكلسترال", "probability": 0.7419921875}, {"start": 1000.21, "end": 1000.47, "word": " أو", "probability": 0.9599609375}, {"start": 1000.47, "end": 1001.27, "word": " للهيموجلوبيين", "probability": 0.63824462890625}, {"start": 1001.27, "end": 1001.43, "word": " عند", "probability": 0.98583984375}, {"start": 1001.43, "end": 1001.77, "word": " أطراف", "probability": 0.9730224609375}, {"start": 1001.77, "end": 1002.25, "word": " الخلية", "probability": 0.9803059895833334}, {"start": 1002.25, "end": 1003.21, "word": " فأخدت", "probability": 0.8439453125}, {"start": 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1010.55, "end": 1011.43, "word": " asymptomatic", "probability": 0.93701171875}], "temperature": 1.0}, {"id": 38, "seek": 103879, "start": 1011.71, "end": 1038.79, "text": "ما بدون أعراض يعني ممكن تنشأ عنا mild anemia الـ Stomatocytosis هي شكل الخلية زي ما أنتوا فاكرين فيها slit في الوسط زي فتحة زي شق بسيط هنا بيبقى فينا خلل في ال permeability بتاعة ال potassium و ال sodium للخلية وهذا بتصير في حالات قديمة بنلاقي من 20 إلى 30% stomatocyte في ال blood film", "tokens": [15042, 47525, 11536, 5551, 3615, 2288, 46958, 37495, 22653, 3714, 43020, 6055, 1863, 8592, 10721, 6225, 8315, 15154, 364, 14058, 2423, 39184, 745, 34295, 905, 4328, 8211, 39896, 13412, 28820, 33962, 1211, 10632, 30767, 1829, 19446, 14739, 2655, 14407, 6156, 995, 37983, 9957, 8978, 11296, 43182, 8978, 2423, 41779, 9566, 30767, 1829, 6156, 2655, 5016, 3660, 30767, 1829, 13412, 4587, 4724, 3794, 1829, 9566, 34105, 4724, 1829, 3555, 4587, 7578, 8978, 8315, 16490, 1211, 1211, 8978, 2423, 30287, 2310, 39894, 995, 27884, 2423, 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117411, "start": 1145.0, "end": 1174.12, "text": "وبنشوف فيها الـ Echinocytes اللي هي الخلايا الـ Crenated بهذا الشكل بتكون موجودة في الـ Peripheral blood تمام؟ هي حالة Pyruvate Kinase Deficiency طيب، نيجي للـ Glucose-6-Fosfate Deficiency هنا زي ما أحنا عارفين أن الهيمoglobin في الوضع الطبيعي بيكون على شكل فرص ومجرد ما يتحول لفرق لأي مؤثر أو أي Oxidant", "tokens": [37746, 1863, 8592, 38688, 8978, 11296, 2423, 39184, 462, 32167, 905, 43673, 13672, 1829, 39896, 33962, 15040, 25528, 2423, 39184, 383, 1095, 770, 39627, 15730, 25124, 28820, 39894, 30544, 3714, 29245, 23328, 3660, 8978, 2423, 39184, 3026, 21240, 304, 3390, 46811, 10943, 22807, 39896, 11331, 6027, 3660, 9953, 894, 19083, 27950, 651, 1346, 1786, 7848, 23032, 1829, 3555, 12399, 8717, 1829, 7435, 1829, 24976, 39184, 5209, 1311, 541, 12, 21, 12, 37, 329, 69, 473, 1346, 1786, 7848, 34105, 30767, 1829, 19446, 5551, 5016, 8315, 6225, 9640, 5172, 9957, 14739, 2423, 3224, 32640, 45841, 13496, 8978, 2423, 2407, 11242, 3615, 41950, 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الـHemoglobin نفسه في مشكلة هذا عادة بيكون inherited", "tokens": [10721, 5172, 11242, 1211, 23032, 16572, 28671, 24976, 12, 4504, 4535, 8211, 5296, 28814, 43761, 10943, 13672, 1829, 31439, 24521, 1256, 320, 8717, 25957, 1211, 8717, 35457, 3660, 2423, 39184, 38, 75, 1311, 541, 1386, 12, 2407, 12984, 5172, 9307, 9673, 29245, 23328, 3660, 8978, 2423, 39184, 49, 7869, 82, 46599, 1863, 4587, 2288, 2288, 11933, 15730, 25961, 21277, 34051, 2847, 23157, 8717, 1829, 7435, 1829, 33962, 1211, 1211, 16712, 6027, 2655, 13672, 1829, 31439, 8717, 31371, 7435, 3660, 16490, 1211, 1211, 20666, 39184, 39, 443, 45841, 13496, 37495, 22653, 2423, 39184, 39, 443, 45841, 13496, 8717, 36178, 3224, 8978, 37893, 28820, 3660, 23758, 6225, 18513, 3660, 4724, 1829, 30544, 27091], "avg_logprob": -0.20521763898432255, "compression_ratio": 1.488, "no_speech_prob": 8.821487426757812e-06, "words": [{"start": 1311.19, "end": 1311.75, "word": "أفضل", "probability": 0.950927734375}, {"start": 1311.75, "end": 1312.11, 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"end": 1317.13, "word": "-وثفات", "probability": 0.543310546875}, {"start": 1317.13, "end": 1317.65, "word": " الموجودة", "probability": 0.966552734375}, {"start": 1317.65, "end": 1317.75, "word": " في", "probability": 0.93505859375}, {"start": 1317.75, "end": 1318.53, "word": " الـRBCs", "probability": 0.74072265625}, {"start": 1318.53, "end": 1319.45, "word": " وبنقرر", "probability": 0.871728515625}, {"start": 1319.45, "end": 1319.67, "word": " إذا", "probability": 0.935546875}, {"start": 1319.67, "end": 1319.91, "word": " كان", "probability": 0.9970703125}, {"start": 1319.91, "end": 1320.33, "word": " Normal", "probability": 0.3857421875}, {"start": 1320.33, "end": 1320.71, "word": " أو", "probability": 0.90771484375}, {"start": 1320.71, "end": 1321.43, "word": " Abnormal", "probability": 0.87353515625}, {"start": 1321.43, "end": 1326.49, "word": " نيجي", "probability": 0.9149169921875}, {"start": 1326.49, "end": 1327.73, "word": " الخلل", "probability": 0.9601236979166666}, {"start": 1327.73, "end": 1328.73, "word": " التالت", "probability": 0.96533203125}, {"start": 1328.73, "end": 1328.93, "word": " اللي", "probability": 0.87548828125}, {"start": 1328.93, "end": 1329.11, "word": " هو", "probability": 0.99169921875}, {"start": 1329.11, "end": 1329.57, "word": " نتيجة", "probability": 0.992431640625}, {"start": 1329.57, "end": 1329.89, "word": " خلل", "probability": 0.9871419270833334}, {"start": 1329.89, "end": 1330.69, "word": " بالـHemoglobin", "probability": 0.767333984375}, {"start": 1330.69, "end": 1331.31, "word": " يعني", "probability": 0.94287109375}, {"start": 1331.31, "end": 1331.91, "word": " الـHemoglobin", "probability": 0.9525553385416666}, {"start": 1331.91, "end": 1332.45, "word": " نفسه", "probability": 0.994140625}, {"start": 1332.45, "end": 1332.77, "word": " في", "probability": 0.94580078125}, {"start": 1332.77, "end": 1333.79, "word": " مشكلة", "probability": 0.8836263020833334}, {"start": 1333.79, "end": 1334.87, "word": " هذا", 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{"start": 1351.43, "end": 1351.69, "word": " بيصير", "probability": 0.980224609375}, {"start": 1351.69, "end": 1352.15, "word": " استبدال", "probability": 0.9833984375}, {"start": 1352.15, "end": 1352.45, "word": " amino", "probability": 0.85986328125}, {"start": 1352.45, "end": 1352.75, "word": " acid", "probability": 0.97998046875}, {"start": 1352.75, "end": 1352.87, "word": " ب", "probability": 0.7041015625}, {"start": 1352.87, "end": 1353.15, "word": " amino", "probability": 0.9033203125}, {"start": 1353.15, "end": 1353.49, "word": " acid", "probability": 0.9833984375}, {"start": 1353.49, "end": 1353.95, "word": " تاني", "probability": 0.8274739583333334}, {"start": 1353.95, "end": 1355.35, "word": " من", "probability": 0.947265625}, {"start": 1355.35, "end": 1356.09, "word": " الأمثلة", "probability": 0.9903564453125}, {"start": 1356.09, "end": 1356.35, "word": " اللي", "probability": 0.91455078125}, {"start": 1356.35, "end": 1356.51, "word": " هو", "probability": 0.92138671875}, {"start": 1356.51, "end": 1357.09, "word": " hemoglobin", "probability": 0.8956705729166666}, {"start": 1357.09, "end": 1357.43, "word": " S", "probability": 0.355224609375}, {"start": 1357.43, "end": 1358.27, "word": " و", "probability": 0.75537109375}, {"start": 1358.27, "end": 1358.79, "word": " hemoglobin", "probability": 0.8611653645833334}, {"start": 1358.79, "end": 1358.95, "word": " C", "probability": 0.9658203125}, {"start": 1358.95, "end": 1359.45, "word": " hemoglobin", "probability": 0.8416341145833334}, {"start": 1359.45, "end": 1359.75, "word": " S", "probability": 0.9541015625}, {"start": 1359.75, "end": 1360.11, "word": " بيصير", "probability": 0.9677734375}, {"start": 1360.11, "end": 1360.79, "word": " substitution", "probability": 0.916015625}], "temperature": 1.0}, {"id": 51, "seek": 139126, "start": 1363.84, "end": 1391.26, "text": "للـ Glutamic Acid بالـ Valine بينما Hemoglobin C لـ Glutamic Acid بيصيرله Substitution بالـ Lysine فبنشأ عندي نوعين من الـ Hemoglobin الـ Abnormal Hemoglobin S و Hemoglobin C يبنيج لـ Hemoglobin S أو Sickle Cell Anemia طبعاً أنتوا عارفينها الـ Sickle Cell Anemia في عندي Two S-Gene ممكن يكون واحد فيهم affected وممكن اتنان", "tokens": [1211, 1211, 39184, 5209, 325, 20726, 5097, 327, 20666, 39184, 7188, 533, 49374, 15042, 18568, 45841, 13496, 383, 5296, 39184, 5209, 325, 20726, 5097, 327, 4724, 1829, 9381, 13546, 43761, 42090, 6518, 20666, 39184, 441, 749, 533, 6156, 3555, 1863, 8592, 10721, 18871, 16254, 8717, 45367, 9957, 9154, 2423, 39184, 18568, 45841, 13496, 2423, 39184, 2847, 23157, 18568, 45841, 13496, 318, 4032, 18568, 45841, 13496, 383, 7251, 3555, 22653, 7435, 5296, 39184, 18568, 45841, 13496, 318, 34051, 43471, 306, 28859, 1107, 14058, 23032, 3555, 3615, 995, 14111, 14739, 2655, 14407, 6225, 9640, 5172, 9957, 11296, 2423, 39184, 43471, 306, 28859, 1107, 14058, 8978, 18871, 16254, 4453, 318, 12, 38, 1450, 3714, 43020, 7251, 30544, 36764, 24401, 8978, 16095, 8028, 4032, 2304, 43020, 1975, 2655, 1863, 7649], 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{"start": 1374.4, "end": 1374.88, "word": " Abnormal", "probability": 0.7086181640625}, {"start": 1374.88, "end": 1375.76, "word": " Hemoglobin", "probability": 0.9231770833333334}, {"start": 1375.76, "end": 1376.02, "word": " S", "probability": 0.84814453125}, {"start": 1376.02, "end": 1376.18, "word": " و", "probability": 0.962890625}, {"start": 1376.18, "end": 1376.74, "word": " Hemoglobin", "probability": 0.9443359375}, {"start": 1376.74, "end": 1377.28, "word": " C", "probability": 0.9892578125}, {"start": 1377.28, "end": 1381.14, "word": " يبنيج", "probability": 0.71392822265625}, {"start": 1381.14, "end": 1381.3, "word": " لـ", "probability": 0.5550537109375}, {"start": 1381.3, "end": 1381.72, "word": " Hemoglobin", "probability": 0.9544270833333334}, {"start": 1381.72, "end": 1381.94, "word": " S", "probability": 0.978515625}, {"start": 1381.94, "end": 1382.1, "word": " أو", "probability": 0.9111328125}, {"start": 1382.1, "end": 1382.44, "word": " Sickle", "probability": 0.94384765625}, {"start": 1382.44, "end": 1382.6, "word": " Cell", "probability": 0.82568359375}, {"start": 1382.6, "end": 1383.02, "word": " Anemia", "probability": 0.9599609375}, {"start": 1383.02, "end": 1383.64, "word": " طبعاً", "probability": 0.854736328125}, {"start": 1383.64, "end": 1383.86, "word": " أنتوا", "probability": 0.8128255208333334}, {"start": 1383.86, "end": 1384.42, "word": " عارفينها", "probability": 0.988671875}, {"start": 1384.42, "end": 1384.66, "word": " الـ", "probability": 0.6041259765625}, {"start": 1384.66, "end": 1384.92, "word": " Sickle", "probability": 0.98046875}, {"start": 1384.92, "end": 1385.04, "word": " Cell", "probability": 0.9306640625}, {"start": 1385.04, "end": 1385.4, "word": " Anemia", "probability": 0.9501953125}, {"start": 1385.4, "end": 1385.6, "word": " في", "probability": 0.8427734375}, {"start": 1385.6, "end": 1385.9, "word": " عندي", "probability": 0.8994140625}, {"start": 1385.9, "end": 1386.12, "word": " Two", "probability": 0.55712890625}, {"start": 1386.12, "end": 1386.56, "word": " S", "probability": 0.8232421875}, {"start": 1386.56, "end": 1387.28, "word": "-Gene", "probability": 0.7263997395833334}, {"start": 1387.28, "end": 1388.28, "word": " ممكن", "probability": 0.976806640625}, {"start": 1388.28, "end": 1389.1, "word": " يكون", "probability": 0.995361328125}, {"start": 1389.1, "end": 1389.46, "word": " واحد", "probability": 0.99267578125}, {"start": 1389.46, "end": 1389.74, "word": " فيهم", "probability": 0.971923828125}, {"start": 1389.74, "end": 1390.18, "word": " affected", "probability": 0.81884765625}, {"start": 1390.18, "end": 1390.72, "word": " وممكن", "probability": 0.8440755208333334}, {"start": 1390.72, "end": 1391.26, "word": " اتنان", "probability": 0.8402099609375}], "temperature": 1.0}, {"id": 52, "seek": 141378, "start": 1392.86, "end": 1413.78, "text": "طبعاً فبتكون Sickle Cell Anemia أو Sickle Cell Atrait هنا بقولك هذه الحالة بتكون Asymptomatic بعد 6 شهور ممكن تبدأ ال symptoms تظهر عليهم ليش Asymptomatic؟ لأن الطفل في هذه الفترة بيكون عنده ال Hemoglobin F مرتفع و ال Hemoglobin F مافي Beta-Cham", "tokens": [9566, 3555, 3615, 995, 14111, 6156, 3555, 2655, 30544, 43471, 306, 28859, 1107, 14058, 34051, 43471, 306, 28859, 1711, 8645, 34105, 4724, 39648, 4117, 29538, 21542, 6027, 3660, 39894, 30544, 1018, 34029, 13143, 39182, 1386, 13412, 3224, 13063, 3714, 43020, 6055, 44510, 10721, 2423, 8332, 6055, 19913, 3224, 2288, 25894, 16095, 32239, 8592, 1018, 34029, 13143, 22807, 5296, 33456, 41950, 5172, 1211, 8978, 29538, 27188, 2655, 25720, 4724, 1829, 30544, 43242, 3224, 2423, 18568, 45841, 13496, 479, 3714, 43500, 5172, 3615, 4032, 2423, 18568, 45841, 13496, 479, 19446, 41185, 33286, 12, 6546, 335], "avg_logprob": -0.19797207732149896, "compression_ratio": 1.537117903930131, "no_speech_prob": 1.990795135498047e-05, "words": [{"start": 1392.8600000000001, "end": 1393.66, "word": "طبعاً", "probability": 0.80966796875}, {"start": 1393.66, "end": 1394.46, "word": " 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{"start": 1411.38, "end": 1412.02, "word": " و", "probability": 0.4013671875}, {"start": 1412.02, "end": 1412.08, "word": " ال", "probability": 0.5908203125}, {"start": 1412.08, "end": 1412.48, "word": " Hemoglobin", "probability": 0.9357096354166666}, {"start": 1412.48, "end": 1412.72, "word": " F", "probability": 0.994140625}, {"start": 1412.72, "end": 1413.06, "word": " مافي", "probability": 0.772705078125}, {"start": 1413.06, "end": 1413.36, "word": " Beta", "probability": 0.529296875}, {"start": 1413.36, "end": 1413.78, "word": "-Cham", "probability": 0.384765625}], "temperature": 1.0}, {"id": 53, "seek": 143938, "start": 1414.38, "end": 1439.38, "text": "فيه Gamma Chain فبالتالي ما راح يبين عنده الخلال غير لما يبدأ Hemoglobin F ينزل ويرفع Hemoglobin A طبعا Hemoglobin A مش هيتكون بشكل كامل لأن الـ Beta Chain اللي في Hemoglobin A affected فهذا راح يؤدي لإنه هيبدأ يتكون عنده الـ Sickle Cell بعد 6 شهور و تبدأ تظهر عنده الأعراض ليش؟ لأنه صار يتكون عنده Hemoglobin S", "tokens": [41185, 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عندى nucleated RBCs وreticulocyte بشكل كبير هدول طبعا حلاقة عندهم Hemoglobin A مش موجود خالص لأن Hemoglobin A شرط في تكوين وجود الـ Beta-Chain هدول ماعندهم الـ Beta-Chain وإنما حلاقة عندهم تقريبا من 80 إلى 100% Hemoglobin S مع ارتفاع في أنواع الـHemoglobin الأخرى اللي مافيها الـBeta-Chain زي Hemoglobin F هاي بقولك عن الـTrait", "tokens": [3224, 1829, 9381, 13546, 7251, 9566, 1211, 3615, 43242, 7578, 3822, 2160, 770, 497, 7869, 82, 4032, 1505, 299, 425, 31078, 975, 4724, 8592, 28820, 9122, 3555, 13546, 8032, 3215, 12610, 23032, 3555, 3615, 995, 11331, 15040, 28671, 43242, 16095, 18568, 45841, 13496, 316, 37893, 3714, 29245, 23328, 16490, 6027, 9381, 5296, 33456, 18568, 45841, 13496, 316, 13412, 2288, 9566, 8978, 6055, 4117, 2407, 9957, 49610, 23328, 2423, 39184, 33286, 12, 6546, 491, 8032, 3215, 12610, 19446, 3615, 41260, 16095, 2423, 39184, 33286, 12, 6546, 491, 4032, 28814, 1863, 15042, 11331, 15040, 28671, 43242, 16095, 6055, 4587, 16572, 3555, 995, 9154, 4688, 30731, 2319, 4, 18568, 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{"start": 1510.86, "end": 1511.02, "word": " Beta", "probability": 0.87109375}, {"start": 1511.02, "end": 1511.4, "word": "-Chain", "probability": 0.9119466145833334}, {"start": 1511.4, "end": 1512.68, "word": " وإنما", "probability": 0.9400634765625}, {"start": 1512.68, "end": 1513.52, "word": " حلاقة", "probability": 0.7150065104166666}, {"start": 1513.52, "end": 1513.88, "word": " عندهم", "probability": 0.989501953125}, {"start": 1513.88, "end": 1514.64, "word": " تقريبا", "probability": 0.9869140625}, {"start": 1514.64, "end": 1515.2, "word": " من", "probability": 0.9765625}, {"start": 1515.2, "end": 1515.52, "word": " 80", "probability": 0.92431640625}, {"start": 1515.52, "end": 1515.72, "word": " إلى", "probability": 0.6708984375}, {"start": 1515.72, "end": 1515.94, "word": " 100", "probability": 0.82958984375}, {"start": 1515.94, "end": 1516.34, "word": "%", "probability": 0.89208984375}, {"start": 1516.34, "end": 1516.84, "word": " Hemoglobin", "probability": 0.94384765625}, {"start": 1516.84, "end": 1517.08, "word": " S", "probability": 0.87158203125}, {"start": 1517.08, "end": 1517.34, "word": " مع", "probability": 0.880859375}, {"start": 1517.34, "end": 1517.88, "word": " ارتفاع", "probability": 0.9375}, {"start": 1517.88, "end": 1518.42, "word": " في", "probability": 0.93505859375}, {"start": 1518.42, "end": 1518.74, "word": " أنواع", "probability": 0.9720052083333334}, {"start": 1518.74, "end": 1519.28, "word": " الـHemoglobin", "probability": 0.7738850911458334}, {"start": 1519.28, "end": 1519.7, "word": " الأخرى", "probability": 0.7808430989583334}, {"start": 1519.7, "end": 1519.82, "word": " اللي", "probability": 0.6474609375}, {"start": 1519.82, "end": 1520.18, "word": " مافيها", "probability": 0.9749348958333334}, {"start": 1520.18, "end": 1520.54, "word": " الـBeta", "probability": 0.7958984375}, {"start": 1520.54, "end": 1520.82, "word": "-Chain", "probability": 0.87744140625}, {"start": 1520.82, "end": 1521.08, "word": " زي", "probability": 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1574.02, "word": " crystallization", "probability": 0.567626953125}, {"start": 1574.02, "end": 1574.18, "word": " في", "probability": 0.873046875}, {"start": 1574.18, "end": 1574.46, "word": " داخل", "probability": 0.95654296875}, {"start": 1574.46, "end": 1574.86, "word": " الخلية", "probability": 0.97802734375}, {"start": 1574.86, "end": 1575.26, "word": " ويظهر", "probability": 0.89716796875}, {"start": 1575.26, "end": 1575.7, "word": " كblock", "probability": 0.783203125}, {"start": 1575.7, "end": 1575.92, "word": " زي", "probability": 0.912353515625}, {"start": 1575.92, "end": 1576.0, "word": " ما", "probability": 0.9482421875}, {"start": 1576.0, "end": 1576.18, "word": " أنتوا", "probability": 0.8180338541666666}, {"start": 1576.18, "end": 1576.6, "word": " شايفين", "probability": 0.987548828125}, {"start": 1576.6, "end": 1576.84, "word": " هذا", "probability": 0.80224609375}, {"start": 1576.84, "end": 1577.16, "word": " هو", "probability": 0.98779296875}, {"start": 1577.16, "end": 1577.44, "word": " في", "probability": 0.88671875}, {"start": 1577.44, "end": 1577.76, "word": " داخل", "probability": 0.9772135416666666}, {"start": 1577.76, "end": 1578.18, "word": " الخلية", "probability": 0.98779296875}, {"start": 1578.18, "end": 1578.34, "word": " الـ", "probability": 0.55126953125}, {"start": 1578.34, "end": 1578.8, "word": " Hemoglobin", "probability": 0.91552734375}, {"start": 1578.8, "end": 1579.02, "word": " C", "probability": 0.955078125}, {"start": 1579.02, "end": 1579.64, "word": " crystals", "probability": 0.6689453125}, {"start": 1579.64, "end": 1580.5, "word": " بنتج", "probability": 0.8116048177083334}, {"start": 1580.5, "end": 1580.76, "word": " عنه", "probability": 0.81298828125}, {"start": 1580.76, "end": 1581.06, "word": " mild", "probability": 0.61474609375}, {"start": 1581.06, "end": 1581.54, "word": " anemia", "probability": 0.884521484375}, {"start": 1581.54, "end": 1582.02, "word": " target", "probability": 0.734375}, {"start": 1582.02, 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affected one gene في تعوين الـ beta chain يعطيني Hemoglobin-C هنا هتلاقيها asymptomatic with no anemia ممكن ألاقي target cells مش هشوف Hemoglobin-C crystals", "tokens": [10721, 4117, 2655, 2288, 9154, 4289, 4, 8032, 2655, 15040, 38436, 18568, 45841, 13496, 12, 34, 21542, 6027, 3660, 16712, 7649, 10632, 14739, 3224, 7251, 3555, 4587, 7578, 472, 9861, 5021, 8028, 472, 12186, 8978, 37279, 2407, 9957, 2423, 39184, 9861, 5021, 37495, 9566, 1829, 22653, 18568, 45841, 13496, 12, 34, 34105, 8032, 2655, 15040, 38436, 11296, 35114, 13143, 365, 572, 364, 14058, 3714, 43020, 5551, 15040, 38436, 3779, 5438, 37893, 8032, 8592, 38688, 18568, 45841, 13496, 12, 34, 23772], "avg_logprob": -0.24054783361929435, "compression_ratio": 1.4754901960784315, "no_speech_prob": 2.1457672119140625e-06, "words": [{"start": 1588.22, "end": 1588.72, "word": "أكتر", "probability": 0.8736572265625}, {"start": 1588.72, "end": 1588.9, "word": " من", "probability": 0.99365234375}, {"start": 1588.9, "end": 1589.3, "word": 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1637.16, "word": " Hemoglobin", "probability": 0.947265625}, {"start": 1637.16, "end": 1637.48, "word": "-S", "probability": 0.9716796875}, {"start": 1637.48, "end": 1638.12, "word": " يعني", "probability": 0.93505859375}, {"start": 1638.12, "end": 1638.38, "word": " صار", "probability": 0.940673828125}, {"start": 1638.38, "end": 1638.62, "word": " فيها", "probability": 0.98388671875}, {"start": 1638.62, "end": 1639.3, "word": " substitution", "probability": 0.6083984375}, {"start": 1639.3, "end": 1640.34, "word": " مختلفة", "probability": 0.9423828125}, {"start": 1640.34, "end": 1640.48, "word": " عن", "probability": 0.96875}, {"start": 1640.48, "end": 1640.96, "word": " التانية", "probability": 0.9593098958333334}], "temperature": 1.0}, {"id": 61, "seek": 166860, "start": 1641.5, "end": 1668.6, "text": "التانية بتعطيني Hemoglobin C طيب هنا هاي هنا هذا شرح للحالة double heterozygous inherit sickle gene from one parent and C gene from other parent both beta chain are abnormal ال lab finding intermediate in severity هتلاقي ال severity بتاعة الحالة متوسطة ما بين ال sickle cell أنميا و sickle cell trait", "tokens": [6027, 2655, 7649, 10632, 39894, 3615, 9566, 9957, 1829, 18568, 45841, 13496, 383, 23032, 1829, 3555, 34105, 8032, 47302, 34105, 23758, 13412, 2288, 5016, 24976, 5016, 6027, 3660, 3834, 3639, 2032, 1229, 70, 563, 21389, 4998, 306, 12186, 490, 472, 2596, 293, 383, 12186, 490, 661, 2596, 1293, 9861, 5021, 366, 32847, 2423, 2715, 5006, 19376, 294, 35179, 8032, 2655, 15040, 38436, 2423, 35179, 39894, 995, 27884, 21542, 6027, 3660, 44650, 41779, 9566, 3660, 19446, 49374, 2423, 4998, 306, 2815, 14739, 2304, 25528, 4032, 4998, 306, 2815, 22538], "avg_logprob": -0.25403792402717507, "compression_ratio": 1.542857142857143, "no_speech_prob": 7.289648056030273e-05, "words": [{"start": 1641.5, "end": 1642.06, "word": "التانية", "probability": 0.8509521484375}, {"start": 1642.06, "end": 1642.62, "word": " بتعطيني", "probability": 0.83447265625}, {"start": 1642.62, 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a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_raw.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..c7682c058257689182030c731a6b7b1ccae26be1 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/NXs0zOkOOK4_raw.srt @@ -0,0 +1,2248 @@ +1 +00:00:01,690 --> 00:00:06,950 +الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبابتتقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +التلاتة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش أني أحفظ إيش تعريف الانيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش ال pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط النتائج هذه مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مساحبة لهذا ال result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات عشان أتأكد من الـresults معينة هذا + +20 +00:01:32,370 --> 00:01:36,290 +الكلام بإذن الله كله راح نناقشه مع بعض شويه شويه + +21 +00:01:36,290 --> 00:01:40,670 +أول حاجة هنشرحه ثالثا + +22 +00:01:40,670 --> 00:01:46,010 +الـ normocytic normochromic anemia خلايا تتميز بأن + +23 +00:01:46,010 --> 00:01:49,970 +حجمها طبيعي والـ hemoglobin content لها طبيعي لكن + +24 +00:01:49,970 --> 00:01:55,630 +فينا حالة أنيمية فينا نقص في + +25 +00:01:55,760 --> 00:01:59,380 +Normochromic Anemia زي ما قلنا الـ Size and + +26 +00:01:59,380 --> 00:02:02,480 +Hemoglobin content is normal but the number of + +27 +00:02:02,480 --> 00:02:06,200 +RBCs decreased يعني الخلل بيكون في عدد الـ RBCs ما + +28 +00:02:06,200 --> 00:02:10,760 +اتأثر أي إشي في الـ erythrocyte نفسها في شكلها في + +29 +00:02:10,760 --> 00:02:14,960 +حجمها في كمية الـ Hemoglobin لكن اللي بتغير عدد + +30 +00:02:14,960 --> 00:02:20,300 +الـ RBCs طبعا هذه إلها أسباب أسبابها الأبلاستيك + +31 +00:02:20,300 --> 00:02:24,160 +أنيميا due to bone marrow failure يعني فينا مشكلة + +32 +00:02:24,160 --> 00:02:28,090 +في الـ bone marrowبلاد لوس أنيميا في عندي أنيميا + +33 +00:02:28,090 --> 00:02:32,450 +سببها فقد كميات من البلد hemolytic anemia + +34 +00:02:32,450 --> 00:02:36,390 +للابلاستيك + +35 +00:02:36,390 --> 00:02:40,890 +أنيميا المشكلة في البون مارو condition of blood + +36 +00:02:40,890 --> 00:02:44,910 +banned cytopenia caused by bone marrow failure + +37 +00:02:44,910 --> 00:02:48,510 +يعني بيبقى في عندنا في البون في البون مارووبالتالي + +38 +00:02:48,510 --> 00:02:52,590 +بتلاقي كل الـ Parameters بتاعة الـ CBC Low من الـ + +39 +00:02:52,590 --> 00:02:56,250 +YPCs من الـ RBCs من الـ Platelets كله بتلاقيهم + +40 +00:02:56,250 --> 00:03:00,750 +الخفضDecreased production of all cell lines and + +41 +00:03:00,750 --> 00:03:05,510 +replacement of marrow with fat هتلاقي أن البون + +42 +00:03:05,510 --> 00:03:09,310 +مارو صار replacement لإله بالـ Yellow marrow + +43 +00:03:09,310 --> 00:03:14,950 +بالفتر طبعا هذا بيكون سببه due to damaged stem + +44 +00:03:14,950 --> 00:03:18,630 +cellsdamage bone marrow environment or suppression + +45 +00:03:18,630 --> 00:03:24,650 +بيصير خلل في الstem cells فبالتالي بينشق عنه + +46 +00:03:24,650 --> 00:03:29,430 +suppression للـ bone marrow في هذه الحالة ما بيصير + +47 +00:03:29,430 --> 00:03:34,250 +تعويض يعني ما بيصير extra medullary hematopoiesis + +48 +00:03:34,250 --> 00:03:37,770 +احنا قلنا ان في بعض الأحيان لما بيصير تكسير في ال + +49 +00:03:37,770 --> 00:03:43,010 +RBCs بيصير extra medullary hematopoiesis عشان يعود + +50 +00:03:43,010 --> 00:03:47,610 +الخلل اللي صار أو النقص اللي صارلكن في هذه الحالة + +51 +00:03:47,610 --> 00:03:50,850 +ما بيصير فبالتالي بيظل الـ hemoglobin و ال + +52 +00:03:50,850 --> 00:03:56,750 +parameters الأخرى كلها منخفضة إيش أنواع ال + +53 +00:03:56,750 --> 00:04:02,330 +aplastic anemia؟ ال aplastic anemia نوعين أو تلت + +54 +00:04:02,330 --> 00:04:06,050 +أنواع رئيسية الأكثر شيوع النوعين اللي هو ال + +55 +00:04:06,050 --> 00:04:09,810 +primary و ال secondary ال primary بيبقى خلل أساسا + +56 +00:04:09,810 --> 00:04:13,250 +في ال hormonal بيبقى سببه idiopathic ال secondary + +57 +00:04:13,820 --> 00:04:18,660 +عادة بتبقى acquired جاية نتيجة تعرض ال patient + +58 +00:04:18,660 --> 00:04:23,900 +لchemicals لبعض الدراجات لinfections لردياشن طبعا + +59 +00:04:23,900 --> 00:04:30,120 +هذه بتشكل تقريبا 50% وهذه بتشكل 50% في نسبة بسيطة + +60 +00:04:30,120 --> 00:04:34,580 +يعني ممكن يكون سببها congenital اللي هي فانكانس + +61 +00:04:34,580 --> 00:04:39,300 +أنيميا هذه بتلاقي أبلاجيا نقص في كل ال parameters + +62 +00:04:39,300 --> 00:04:43,200 +يعني نفس ال picture بتاعة الأبلاستيك أنيميابتكون + +63 +00:04:43,200 --> 00:04:48,820 +مصاحبة بـ dwarfism وبتكون معاها كمان skeletal + +64 +00:04:48,820 --> 00:04:52,940 +abnormalities شوية mental retardation abnormal + +65 +00:04:52,940 --> 00:04:57,400 +skin pigmentation يعني هتلاقي فيه تلون في ال skin + +66 +00:04:57,400 --> 00:05:02,880 +بالاضافة لأقزمة قصر في القانة كمان بتلاقي تشوه في + +67 +00:05:02,880 --> 00:05:05,860 +ال skeletal bone + +68 +00:05:10,870 --> 00:05:14,270 +diagnosis of aplastic anemia أول حاجة قلنا احنا + +69 +00:05:14,270 --> 00:05:18,330 +سمناها normocytic-normochromic فهتلاقي ان ال MCV و + +70 +00:05:18,330 --> 00:05:24,030 +ال MCH و ال MCHC normal ال reticulocyte low ليش + +71 +00:05:24,030 --> 00:05:27,850 +low؟ لأنه أساسا مافيش تنبيه للبون مرة أنه يصنع + +72 +00:05:27,850 --> 00:05:31,490 +خلايا فبالتالي هتلاقي في كسل في البون مرة فبتلاقي + +73 +00:05:31,490 --> 00:05:35,170 +مش هتلاقي يعني فبالتالي مش هنلاقي reticulocyte + +74 +00:05:35,170 --> 00:05:39,530 +normal هنلاقيها قليلة هنلاقي نقص في ال hemoglobin + +75 +00:05:39,950 --> 00:05:44,470 +زي ما قلنا band-cytopenia مش هنلاقي أي abnormal + +76 +00:05:44,470 --> 00:05:47,150 +cells يعني كل الخلايا هتلاقيها normal لا هتلاقي + +77 +00:05:47,150 --> 00:05:49,770 +abnormality في الـ size ولا هتلاقي abnormality في + +78 +00:05:49,770 --> 00:05:55,150 +الشباب hypoplegia of bone marrow يعني تفبيط أو قلة + +79 +00:05:55,150 --> 00:05:58,610 +في نشاط الـ bone marrow بقى ال parameters التانية + +80 +00:05:58,610 --> 00:06:03,410 +زي ال serum iron ال vitamin B12 الفولات هتلاقيهم + +81 +00:06:03,410 --> 00:06:06,430 +normal هتلاقيهماش normal + +82 +00:06:13,210 --> 00:06:16,370 +نأتي إلى الـ Hemolytic Anemia النوع التاني إذا + +83 +00:06:16,370 --> 00:06:19,390 +النوع الأول حكينا عنه أبلاستيك أنيميا النوع التاني + +84 +00:06:19,390 --> 00:06:24,410 +هو Hemolytic Anemia الـ Hemolytic Anemia بيكون + +85 +00:06:24,410 --> 00:06:30,310 +بسبب زيادة في تكسير الـ premature red cells قد + +86 +00:06:30,310 --> 00:06:35,170 +تكون compensated أو uncompensated يعني ممكن بون + +87 +00:06:35,170 --> 00:06:39,450 +مارو يقدر يتعامل معاها وممكن ما يقدر يتعامل معاها + +88 +00:06:39,450 --> 00:06:44,130 +حسب ال rate of hemolysisطبعا الـ Hemolytic Anemia + +89 +00:06:44,130 --> 00:06:47,870 +بتؤدي لإيش لـ Hyperplasia مافي عندنا مشكلة في الـ + +90 +00:06:47,870 --> 00:06:52,390 +Boomerang و هذا بيترتب عنه إن الـ Erythroid + +91 +00:06:52,390 --> 00:06:55,910 +precursors بتصير تنشط فبتلاقي الـ Myeloid + +92 +00:06:55,910 --> 00:06:59,490 +Erythroid Ratio انخفضت لأن الـ Erythroid بتزيد + +93 +00:06:59,490 --> 00:07:04,210 +Boomerang Red Cells Production increase 6 to 8 + +94 +00:07:04,210 --> 00:07:07,990 +times يعني بتزيد من 6 إلى 8 مرات الوضع الطبيعي + +95 +00:07:07,990 --> 00:07:12,370 +برضه ال reticulocyte هتلاقيها مرتفعةmarked + +96 +00:07:12,370 --> 00:07:16,770 +reticulocytosis ونلاقي كمان inucleated RBCs في الـ + +97 +00:07:16,770 --> 00:07:24,170 +peripheral blood الآن + +98 +00:07:24,170 --> 00:07:28,130 +بالنسبة لتكسير الخلايا في الـ hemolytic anemia قد + +99 +00:07:28,130 --> 00:07:31,970 +تكون بسبب intravascular hemolysis يعني في داخل ال + +100 +00:07:31,970 --> 00:07:34,770 +blood vessels في الcirculation أو يكون ال + +101 +00:07:34,770 --> 00:07:38,190 +hemolysis extravascular في ال reticuloendothelial + +102 +00:07:38,190 --> 00:07:38,850 +system + +103 +00:07:42,650 --> 00:07:46,850 +نجي للنوع الأول اللي هو الـ Extravascular + +104 +00:07:46,850 --> 00:07:51,950 +Hemolysis الـ Extravascular Hemolysis هنلاحظ فيه + +105 +00:07:51,950 --> 00:07:56,530 +إن هو بيمشي بنفس ال pathway الطبيعي اللي بيصير فيه + +106 +00:07:56,530 --> 00:08:00,410 +تكسير لل RBCs لما يصير لها aging لكن على وطيرة + +107 +00:08:00,410 --> 00:08:03,950 +أسرع يعني إحنا عارفين إن ال RBCs لما يصير لها + +108 +00:08:03,950 --> 00:08:12,040 +aging طبعا بالإضافة لل abnormal RBCsهتروح على الـ + +109 +00:08:12,040 --> 00:08:15,600 +reticuloendothelial system هناك الـ macrophages + +110 +00:08:15,600 --> 00:08:18,740 +هتعملها removal طبعا ال reticuloendothelial system + +111 +00:08:18,740 --> 00:08:23,100 +عارفين بومار و لفرقة عصبين هناك هيصير تكسير لل + +112 +00:08:23,100 --> 00:08:27,860 +RBCs هلأ لما بيصير لل RBCs تكسير هيصير طبعا + +113 +00:08:27,860 --> 00:08:33,680 +بالنسبة للهيموجلوبين هيصير release للهيم أندجلوبين + +114 +00:08:34,150 --> 00:08:38,690 +الجلوبين هيروح ويكوّن أخر أمينو أسد طبعاً الأمينو + +115 +00:08:38,690 --> 00:08:43,110 +أسد هتستخدم لـ protein synthesis بضل عندنا الهيم + +116 +00:08:43,110 --> 00:08:46,250 +الهيم بتكون من iron بيصير له reabsorption عشان + +117 +00:08:46,250 --> 00:08:50,810 +يستخدم مرة أخرى و بعدين الهيم الهيم طبعاً عفوا + +118 +00:08:50,810 --> 00:08:55,410 +البروتوبرفيرين البروتوبرفيرين هيصير له تكسير و + +119 +00:08:55,410 --> 00:08:59,450 +هيتحول ل unconjugated bilirubin طبعا ال + +120 +00:08:59,450 --> 00:09:05,310 +unconjugated bilirubin هذا يعني بيكون موجوداللي + +121 +00:09:05,310 --> 00:09:09,010 +بالـ reticuloendothelial system بشكل عام بده ينتقل + +122 +00:09:09,010 --> 00:09:12,810 +للـ liver علشان ينتقل بال liver هو water insoluble + +123 +00:09:12,810 --> 00:09:17,410 +فبالتالي بيرتبط بالألبومين بروح هناك بدخل ال liver + +124 +00:09:17,410 --> 00:09:21,650 +فبترك الألبومين طبيعي الألبومين كان كناقل بس لما + +125 +00:09:21,650 --> 00:09:27,200 +بدخل لل liverبيصير له esterification بإضافة two + +126 +00:09:27,200 --> 00:09:31,000 +glucuronic acid فبتحول ل conjugated bilirubin + +127 +00:09:31,000 --> 00:09:35,560 +فالconjugated bilirubin هينزل على ال intestine من + +128 +00:09:35,560 --> 00:09:39,840 +ال liver عبر ال bile duct لل intestine طبعا هذا + +129 +00:09:39,840 --> 00:09:42,740 +جزء من انه هيصير له reabsorption عن طريق ال + +130 +00:09:42,740 --> 00:09:47,760 +intestineويتحول لـ Yerobilinogen و Yerobiline + +131 +00:09:47,760 --> 00:09:50,460 +طبعاً هيعود بعد نسير الـ absorption يمشي في الـ + +132 +00:09:50,460 --> 00:09:53,220 +blood وبعدين يروح لل urine وينزل على شكل + +133 +00:09:53,220 --> 00:09:57,780 +Yerobilinogen هذه هي ال pathway بتاعة التكسير + +134 +00:09:57,780 --> 00:10:02,060 +الطبيعي اللي بتصير في الجسم يعني هذه لما بيصير + +135 +00:10:02,060 --> 00:10:05,680 +aging للخلايا هيك بتتأثر في الـ Extravascular + +136 +00:10:05,680 --> 00:10:10,360 +Hemolysis هذا اللي بيصير بس بوتيرة عالية يعني مش + +137 +00:10:10,360 --> 00:10:16,420 +بالشكل الطبيعي اللي بيصيرزيادة الـ RBCD breakdown + +138 +00:10:16,420 --> 00:10:20,660 +طبعاً الـ bilirubin هيرتفع ليش؟ لأنه زاد التكسير + +139 +00:10:20,660 --> 00:10:25,500 +فزاد التكسير البروتوبرفيرين تحوله لـ bilirubin + +140 +00:10:25,500 --> 00:10:29,480 +وبالتالي هيبلش الـ bilirubin يرتفع stool + +141 +00:10:29,480 --> 00:10:32,900 +ياروبايلينوجين و blood yaroboilinogen و urine + +142 +00:10:32,900 --> 00:10:35,580 +yaroboilinogen هدول نوادج الـ bilirubin كلها + +143 +00:10:35,580 --> 00:10:41,440 +هنلاقيها انها ارتفعت هذا إذن وان في الـ + +144 +00:10:41,440 --> 00:10:42,940 +Extravascular Hemolysis + +145 +00:10:46,970 --> 00:10:51,250 +الـ Intravascular Hemolysis هنا بيصير التكسير في + +146 +00:10:51,250 --> 00:10:54,470 +داخل الـ blood vessels بيصير في داخل الـ blood + +147 +00:10:54,470 --> 00:10:59,770 +vessels والهيموجلوبين هذا عادة عادة ممكن يصير + +148 +00:10:59,770 --> 00:11:05,670 +نتيجة complement activation يعني ممكن يكون نتيجة + +149 +00:11:05,670 --> 00:11:12,230 +immune hemolysis وتحفيز للـ complement فما يعني ما + +150 +00:11:12,230 --> 00:11:15,010 +بيروح الـ radiculoendothelial system بتكسر في داخل + +151 +00:11:15,010 --> 00:11:19,300 +الـ circulationهذا بنتج عنه وجود إكسرة الخلية + +152 +00:11:19,300 --> 00:11:21,700 +هيطلع الـ Hemoglobin منها الأصل إن الـ Hemoglobin + +153 +00:11:21,700 --> 00:11:24,680 +ما بيكون free في ال blood هنا حيصير في عندنا free + +154 +00:11:24,680 --> 00:11:29,280 +Hemoglobin طبعا الـ free Hemoglobin بده ينتقل للـ + +155 +00:11:29,280 --> 00:11:33,560 +liver كيف بينتقل عن طريق الـ Heptoglobin اللي هو + +156 +00:11:33,560 --> 00:11:38,120 +البروتين ال carrier للـ Hemoglobin الـ Heptoglobin + +157 +00:11:38,120 --> 00:11:42,580 +هنا هتنقص كميتو لأنه هيصير saturated أو منشغل و + +158 +00:11:42,580 --> 00:11:47,650 +مرتبط بالـ Hemoglobinطيب فى كمية من الـ Hemoglobin + +159 +00:11:47,650 --> 00:11:51,490 +برضه هتظل Free هيصيرلها في التراشن عبر الكدنى + +160 +00:11:51,490 --> 00:11:56,410 +Aglomeruli الآن لو كان ال rate للـ Hemolysis كتير + +161 +00:11:56,410 --> 00:11:59,490 +كبير وما .. يعني ماقدرش يعمل Reabsorption للـ + +162 +00:11:59,490 --> 00:12:02,330 +Hemoglobin اللى بينزل هيبدأ يطلع عند Free + +163 +00:12:02,330 --> 00:12:06,370 +Hemoglobin ينزل في ال urine هناك في ال bladder + +164 +00:12:06,370 --> 00:12:12,230 +هيوصل لـ bladder طبعا وهيبدأشكمية من الـ + +165 +00:12:12,230 --> 00:12:16,690 +Hemocydrine تترثب أو تتكون في الـ urine وألاخظها + +166 +00:12:16,690 --> 00:12:20,590 +أو ألاقيها بشكل واضح، إذن هنا في الـ Intravascular + +167 +00:12:20,590 --> 00:12:25,050 +Hemolysis بتميز بإنه فيه Free Hemoglobin ونشأ عنه + +168 +00:12:25,050 --> 00:12:29,130 +Heptoglobin، بعدين في الـ urine بلاقي Hemocydrine + +169 +00:12:29,130 --> 00:12:34,170 +Hemoglobinuria + +170 +00:12:34,170 --> 00:12:39,680 +الـ Lab Features، وجود Hemoglobin في الـ urineأو + +171 +00:12:39,680 --> 00:12:42,260 +Hemoglobinemia يعني وجود Hemoglobin في blood أو + +172 +00:12:42,260 --> 00:12:45,760 +Hemoglobin يوريا وفي ال urine Hemocydrinuria وجود + +173 +00:12:45,760 --> 00:12:49,380 +Hemocydrin في ال urine Reduced or absent serum + +174 +00:12:49,380 --> 00:12:52,880 +haptoglobin لأنه هتلاقي ارتبط بال Hemoglobin عشان + +175 +00:12:52,880 --> 00:13:00,080 +يودي لل metabolism نيجي + +176 +00:13:00,080 --> 00:13:04,040 +لأنواع ال Hemolytic Anemia بداية ال Hereditary + +177 +00:13:04,040 --> 00:13:10,000 +Hemolytic Anemiaطبعا هنا هذه عادة بتكون congenital + +178 +00:13:10,000 --> 00:13:15,120 +ممكن تبين بداية عند الولادة أو ممكن خلال مراحل + +179 +00:13:15,120 --> 00:13:19,700 +الحياة في بعضها بيضل silent يعني مافيش عليه مافيش + +180 +00:13:19,700 --> 00:13:24,760 +ال patient عليه أي أعراض لغاية ما يتعرض لمؤثر يبين + +181 +00:13:24,760 --> 00:13:32,440 +هذه المشكلة زي الـ G6PD ممكن طيب هذه إيش أسبابها + +182 +00:13:32,440 --> 00:13:37,700 +أسبابها خلالفي الـ Red Cell قد يكون السبب هذا + +183 +00:13:37,700 --> 00:13:44,600 +نتيجة Membrane defect أو خلل في الـ Metabolism طيب + +184 +00:13:44,600 --> 00:13:49,520 +نيجي أول حاجة لمشاكل بالـ membrane defect مشاكل + +185 +00:13:49,520 --> 00:13:53,260 +الـ membrane defect قد تكون يعني من أمثلتها + +186 +00:13:53,260 --> 00:13:56,120 +Spherocytosis وElliptocytosis اللي بتنشأ عنها + +187 +00:13:56,120 --> 00:13:59,800 +أشكال abnormal للخلايا والأشكال هذه هيصير لها أكيد + +188 +00:13:59,800 --> 00:14:05,570 +تكسيرهنا مثلا نجي لـ Spherocytosis Spherocytosis + +189 +00:14:05,570 --> 00:14:09,950 +هنا بيصير خلل في الاسبكتين و الانكايرين دول + +190 +00:14:09,950 --> 00:14:11,630 +التانين المسؤولين عن + +191 +00:14:14,560 --> 00:14:17,640 +الـ Flexibility بتاعة الـ Erythrocyte يعني انه الـ + +192 +00:14:17,640 --> 00:14:21,340 +biconcave shape تبعها مسؤولين عنه زي الـ rubber زي + +193 +00:14:21,340 --> 00:14:24,460 +المغاطة بيبقوا في الخلية داخل الخلية خيوط من + +194 +00:14:24,460 --> 00:14:27,500 +البروتين مسؤولين عن شكل الـ biconcave بتاع الخلية + +195 +00:14:27,500 --> 00:14:31,180 +فإذا صار فقد فيهم أو نقص فيهم هتبدأ الخلية تاخد + +196 +00:14:31,180 --> 00:14:34,740 +الـ Spherocyte أضف إلى بعض الحالات اللي بيبقى فيها + +197 +00:14:34,740 --> 00:14:39,080 +خلل بال permeability بتاعة الممبرينفبالتالي بتزود + +198 +00:14:39,080 --> 00:14:44,840 +تدخيل الـ Sodium ions لداخل الخلية وبالتالي بتبعها + +199 +00:14:44,840 --> 00:14:49,080 +الميّه وفي بعض الحالات ممكن تكون نتيجة Hemolytic + +200 +00:14:49,080 --> 00:14:54,920 +Anemia زي في حالات الـ Autoimmune Hemolytic Anemia + +201 +00:14:54,920 --> 00:14:59,200 +المرحلة يعني لما بيصير complement fixation هتبدأ + +202 +00:14:59,200 --> 00:15:02,760 +الخلية يصيرلها perforation لما بيصير perforation + +203 +00:15:02,760 --> 00:15:05,460 +الخلية هتبلش ال fluids تدخل فيها في كمية كبيرة + +204 +00:15:05,460 --> 00:15:09,490 +فهتصير Spherocyteو بعد هيك هيصير لها Rapture هنا + +205 +00:15:09,490 --> 00:15:13,090 +بيبين عندنا لما بيصير جزء يعني لصلة جزء من الـ + +206 +00:15:13,090 --> 00:15:17,770 +membrane كيف ممكن خلية تتحول إلى Spherocyte ال lab + +207 +00:15:17,770 --> 00:15:21,510 +finding طبعا الانيميا بتكون مختلفة يعني مش كل + +208 +00:15:21,510 --> 00:15:24,590 +الحالات على نفس ال degree من الانيميا حلاق + +209 +00:15:24,590 --> 00:15:30,550 +Spherocyte في السمير هتلاقي ال MCHC مرتفع فلقيت يا + +210 +00:15:30,550 --> 00:15:36,380 +بنات اتطلعوا معايا الخلية هذه هي Spherocyteالخلية + +211 +00:15:36,380 --> 00:15:41,900 +هنا أصار يعني أصارت الخلية منتفخة واختفى فيها الـ + +212 +00:15:41,900 --> 00:15:45,680 +Biconcave shape هذه الخلايا الـ Serocyte يعني هي + +213 +00:15:45,680 --> 00:15:50,740 +اللى بنربطها دايما بارتفاع الـ MCHC وارتفاع الـ + +214 +00:15:50,740 --> 00:15:55,640 +MCHالـ MCH-C والـ MCH ارتفاعهم لحاله لا يعني شيء + +215 +00:15:55,640 --> 00:15:59,340 +لكن عادة هو مرتبط بالـ Spherocyte لأنه فلاقى أن + +216 +00:15:59,340 --> 00:16:02,400 +الـ Cell Membrane تاع الخلية صغر شوية فبالتالي + +217 +00:16:02,400 --> 00:16:06,540 +صارت نسبة الـ Hemoglobin فيها مرتفعة الـ MCH-C + +218 +00:16:06,540 --> 00:16:10,800 +فيها مرتفع يعني a high body chromia Increased + +219 +00:16:10,800 --> 00:16:13,860 +Osmotic Fragility Test وهذا طبعا الفحص إذا كنتوا + +220 +00:16:13,860 --> 00:16:18,000 +فاكرين اللي بيميز الـ Spherocytosis فحص الـ + +221 +00:16:18,000 --> 00:16:19,080 +Osmotic Fragility + +222 +00:16:21,790 --> 00:16:26,010 +نأتي للـ ovalocytosis أو الابتو سايتوزز بتكون + +223 +00:16:26,010 --> 00:16:30,890 +الخلية شكلها رفيعة زي ما أنتوا شايفين هنا + +224 +00:16:30,890 --> 00:16:38,130 +ovalocyte شايفين كيف شكلها هنا هذا بيكون سببه أنه + +225 +00:16:38,130 --> 00:16:41,430 +أصار polarization للكلسترال أو للهيموجلوبيين عند + +226 +00:16:41,430 --> 00:16:47,570 +أطراف الخلية فأخدت هذا الشكل هنلاقي تقريبا 25% أو + +227 +00:16:47,570 --> 00:16:52,310 +أكثر of ovalocytes عادة بتكون asymptomaticما بدون + +228 +00:16:52,310 --> 00:16:58,510 +أعراض يعني ممكن تنشأ عنا mild anemia الـ + +229 +00:16:58,510 --> 00:17:01,790 +Stomatocytosis هي شكل الخلية زي ما أنتوا فاكرين + +230 +00:17:01,790 --> 00:17:06,150 +فيها slit في الوسط زي فتحة زي شق بسيط هنا بيبقى + +231 +00:17:06,150 --> 00:17:11,530 +فينا خلل في ال permeability بتاعة ال potassium و + +232 +00:17:11,530 --> 00:17:15,470 +ال sodium للخلية وهذا بتصير في حالات قديمة بنلاقي + +233 +00:17:15,470 --> 00:17:21,240 +من 20 إلى 30% stomatocyte في ال blood filmممكن + +234 +00:17:21,240 --> 00:17:24,740 +يصير فيها mild to severe hemolytic anemia هي الـ + +235 +00:17:24,740 --> 00:17:31,200 +Stomatocyte بشكل واضح كتير فيها نيجي + +236 +00:17:31,200 --> 00:17:34,440 +للـ Acantocyte الـ Acantocyte اللي هي زي ما أنتوا + +237 +00:17:34,440 --> 00:17:40,300 +شايفين كأنها Speculated cell خلية إلها خطاطيف هذا + +238 +00:17:40,300 --> 00:17:43,020 +بيكون ناتج عن خلل في الـ lipids الـ Beta + +239 +00:17:43,020 --> 00:17:47,120 +-Lipoprotein اللي هي مكونة للـ cell membrane أو من + +240 +00:17:47,120 --> 00:17:50,370 +مكونات الـ cell membraneفبالتالي بتلاقي خلل في + +241 +00:17:50,370 --> 00:17:55,870 +تركيبة الـ Cell Membrane بيؤدى لحدوث هذا الشكل هي + +242 +00:17:55,870 --> 00:18:00,730 +خليط الـ Acanthocyte طبعا هنلاقي كمية الـ + +243 +00:18:00,730 --> 00:18:05,070 +Acanthocyte في السمير يعني كبيرة وموجودة وملحوظة + +244 +00:18:05,070 --> 00:18:09,370 +حسب الحالة أو حسب المشكلة بينتج عنها Mild Anemia + +245 +00:18:09,370 --> 00:18:13,650 +ممكن يسموها اسم تانى Beta-Lipoproteinemia يعني ان + +246 +00:18:13,650 --> 00:18:16,890 +في خلل في الـ Beta-Lipoprotein المكون للـ Cell + +247 +00:18:16,890 --> 00:18:17,450 +Membrane + +248 +00:18:22,170 --> 00:18:27,610 +طيب النوع التاني احنا اول اش يقولنا خلل بالـ cell + +249 +00:18:27,610 --> 00:18:32,130 +membrane و ذكرنا الأشكال خلل في ال enzymes اللي + +250 +00:18:32,130 --> 00:18:34,990 +موجودة بالخلايا من ال enzymes اللي ممكن يشتغل فيها + +251 +00:18:34,990 --> 00:18:38,810 +مشاكل الـ pyruvate kinase والجلوكوز 6-phosphate + +252 +00:18:38,810 --> 00:18:42,940 +dehydrogenaseفي الـ Pyruvate Kinase بيبقى فيه خلل + +253 +00:18:42,940 --> 00:18:47,380 +في تكوين الـ ATP طبعا الـ ATP مسؤولة بشكل كبير عن + +254 +00:18:47,380 --> 00:18:50,520 +وظائف كتير في الخلية من ضمن الوظائف المسؤولة عنها + +255 +00:18:50,520 --> 00:18:53,880 +الـ ATP اللي هي Sodium Potassium Pump اللي هي الـ + +256 +00:18:53,880 --> 00:18:57,440 +Cation Pump طبعا وجود خلل أو تلف في Sodium + +257 +00:18:57,440 --> 00:19:00,680 +Potassium Pump هيعمل عندى هذا الشكل الـ Abnormal + +258 +00:19:00,680 --> 00:19:04,060 +للخلايا وهذه بتكون مساحبة بـ Severe Hemolytic + +259 +00:19:04,060 --> 00:19:07,960 +Anemiaوبنشوف فيها الـ Echinocytes اللي هي الخلايا + +260 +00:19:07,960 --> 00:19:11,880 +الـ Crenated بهذا الشكل بتكون موجودة في الـ + +261 +00:19:11,880 --> 00:19:15,560 +Peripheral blood تمام؟ هي حالة Pyruvate Kinase + +262 +00:19:15,560 --> 00:19:19,860 +Deficiency طيب، نيجي للـ Glucose-6-Fosfate + +263 +00:19:19,860 --> 00:19:24,600 +Deficiency هنا زي ما أحنا عارفين أن الهيمoglobin + +264 +00:19:24,600 --> 00:19:29,920 +في الوضع الطبيعي بيكون على شكل فرص ومجرد ما يتحول + +265 +00:19:29,920 --> 00:19:35,850 +لفرق لأي مؤثر أو أي Oxidantفي ميكانيزم بالجسم + +266 +00:19:35,850 --> 00:19:41,750 +الميكانيزم هذه بترجع عن طريق الـ Net pH و بتروح و + +267 +00:19:41,750 --> 00:19:45,470 +هي مرجعة على ash لفرس على أساس إنه يقوم بوظيفته + +268 +00:19:45,470 --> 00:19:48,310 +لكن لو ضلوا على شكل فرق اللي بسميه الـ Hemoglobin + +269 +00:19:48,310 --> 00:19:51,050 +في هذه الحالة مت-Hemoglobin راح يكون non + +270 +00:19:51,050 --> 00:19:54,370 +-functional هدول الناس عندهم خلل في الـGlucose-6 + +271 +00:19:54,370 --> 00:19:57,470 +-Fosfate اللي داخل في ال pathway تتكوين الـNet pH + +272 +00:19:57,470 --> 00:20:01,110 +وبالتالي لما يكون فيه نقص في الـNet pH لو + +273 +00:20:01,110 --> 00:20:07,060 +الـHemoglobin صار لهأو Oxidation مش هيقدر يرجع + +274 +00:20:07,060 --> 00:20:10,760 +والأصل برجع بال pathway هذا اللي هو added by NADPH + +275 +00:20:10,760 --> 00:20:15,940 +اللي هو added by Glucosic Phosphate طالما هذا مش + +276 +00:20:15,940 --> 00:20:19,200 +موجود الـ NADPH مش هيتقوم بشكل كافي فبالتالي هيظل + +277 +00:20:19,200 --> 00:20:24,200 +ال Hemoglobin على شكل Methemoglobin وطبعا هدول + +278 +00:20:24,200 --> 00:20:27,100 +الناس زي ما انتوا عارفين بيكونوا موجودين أو عايشين + +279 +00:20:27,100 --> 00:20:30,780 +بشكل طبيعي يوم اللي يتعرضوا ل Oxidant هتلاقي أنه + +280 +00:20:30,780 --> 00:20:35,460 +صار Oxidationعندهم وصارت عندهم اللي هي الأعراض + +281 +00:20:35,460 --> 00:20:39,660 +فبالتالي هم طالما مافيش Occident هم عايشين بشكل + +282 +00:20:39,660 --> 00:20:42,880 +طبيعي لكن لو اتعرضوا لـ Occident هيتكون عندهم + +283 +00:20:42,880 --> 00:20:47,480 +hence bodies الـ hence bodies في الخلية هتأدي إلى + +284 +00:20:47,480 --> 00:20:50,920 +الـ RBCs destruction هي هنا بقولك هذا الفيلم تبعهم + +285 +00:20:50,920 --> 00:20:54,660 +لو كانوا طبيعيين بدون ما يتعرضوا لأي Occident + +286 +00:21:01,090 --> 00:21:06,250 +نأتي هنا لو أتعرضوا لـ Oxidant أيش راح يصير معهم + +287 +00:21:06,250 --> 00:21:11,990 +هنلاحظ أنه هيتكوّن عندهم الـ Hense Body طبعاً لما + +288 +00:21:11,990 --> 00:21:15,450 +يتكوّن الـ Hense Body بيروح على الخلايا هذه هتروح + +289 +00:21:15,450 --> 00:21:20,210 +هيصير فيها هتبدأ الـ Macrophage تعملها Biting + +290 +00:21:20,210 --> 00:21:25,510 +هتعضها يعني هتقدم هذا الجزء وممكن بالتالي يعود الـ + +291 +00:21:25,510 --> 00:21:29,230 +Cell Membrane يلتقم فبالتالي الخلية ممكن تصير + +292 +00:21:29,230 --> 00:21:33,980 +Spherocyteهدول الناس بلاقي عندهم schistocyte، + +293 +00:21:33,980 --> 00:21:38,000 +spherocyte due to pitting of hen's bodies by + +294 +00:21:38,000 --> 00:21:42,040 +spleen بنلاقي عندهم moderate to severe anemia طبعا + +295 +00:21:42,040 --> 00:21:45,840 +هذه أفضل طريقة لإن هي الأشكال اللي بشوف ممكن أشوف + +296 +00:21:45,840 --> 00:21:49,480 +schistocyte ممكن أشوف schistocyte وأشكال مختلفة + +297 +00:21:49,480 --> 00:21:53,530 +damaged herpesأفضل طريقة لل-diagnosis لإلهام اللي + +298 +00:21:53,530 --> 00:21:57,130 +هو enzyme assay نعمل نسبة الـGlucose 6-وثفات + +299 +00:21:57,130 --> 00:22:00,710 +الموجودة في الـRBCs وبنقرر إذا كان Normal أو + +300 +00:22:00,710 --> 00:22:06,490 +Abnormal نيجي + +301 +00:22:06,490 --> 00:22:11,310 +الخلل التالت اللي هو نتيجة خلل بالـHemoglobin يعني + +302 +00:22:11,310 --> 00:22:15,750 +الـHemoglobin نفسه في مشكلة هذا عادة بيكون + +303 +00:22:15,750 --> 00:22:21,650 +inheritedطبعاً معظم الحالات دي هنلاقي فيها target + +304 +00:22:21,650 --> 00:22:25,750 +cells من الأمثلة اللي هي beta chain amino acid + +305 +00:22:25,750 --> 00:22:29,190 +substitution بتطلع عندنا variant hemoglobin يعني + +306 +00:22:29,190 --> 00:22:32,150 +بيصير عندنا خلل في ال beta chain ده بيصير استبدال + +307 +00:22:32,150 --> 00:22:36,510 +amino acid ب amino acid تاني من الأمثلة اللي هو + +308 +00:22:36,510 --> 00:22:40,110 +hemoglobin S و hemoglobin C hemoglobin S بيصير + +309 +00:22:40,110 --> 00:22:40,790 +substitution + +310 +00:22:43,840 --> 00:22:47,460 +للـ Glutamic Acid بالـ Valine بينما Hemoglobin C + +311 +00:22:47,460 --> 00:22:52,460 +لـ Glutamic Acid بيصيرله Substitution بالـ Lysine + +312 +00:22:52,460 --> 00:22:54,880 +فبنشأ عندي نوعين من الـ Hemoglobin الـ Abnormal + +313 +00:22:54,880 --> 00:23:01,140 +Hemoglobin S و Hemoglobin C يبنيج + +314 +00:23:01,140 --> 00:23:03,860 +لـ Hemoglobin S أو Sickle Cell Anemia طبعاً أنتوا + +315 +00:23:03,860 --> 00:23:07,280 +عارفينها الـ Sickle Cell Anemia في عندي Two S-Gene + +316 +00:23:07,280 --> 00:23:13,660 +ممكن يكون واحد فيهم affected وممكن اتنانطبعاً + +317 +00:23:13,660 --> 00:23:17,140 +فبتكون Sickle Cell Anemia أو Sickle Cell Atrait + +318 +00:23:17,140 --> 00:23:23,160 +هنا بقولك هذه الحالة بتكون Asymptomatic بعد 6 شهور + +319 +00:23:23,160 --> 00:23:27,400 +ممكن تبدأ ال symptoms تظهر عليهم ليش Asymptomatic؟ + +320 +00:23:27,400 --> 00:23:30,740 +لأن الطفل في هذه الفترة بيكون عنده ال Hemoglobin F + +321 +00:23:30,740 --> 00:23:35,460 +مرتفع و ال Hemoglobin F مافي Beta-Chamفيه Gamma + +322 +00:23:35,460 --> 00:23:38,760 +Chain فبالتالي ما راح يبين عنده الخلال غير لما + +323 +00:23:38,760 --> 00:23:42,860 +يبدأ Hemoglobin F ينزل ويرفع Hemoglobin A طبعا + +324 +00:23:42,860 --> 00:23:45,580 +Hemoglobin A مش هيتكون بشكل كامل لأن الـ Beta + +325 +00:23:45,580 --> 00:23:49,280 +Chain اللي في Hemoglobin A affected فهذا راح يؤدي + +326 +00:23:49,280 --> 00:23:54,020 +لإنه هيبدأ يتكون عنده الـ Sickle Cell بعد 6 شهور و + +327 +00:23:54,020 --> 00:23:58,380 +تبدأ تظهر عنده الأعراض ليش؟ لأنه صار يتكون عنده + +328 +00:23:58,380 --> 00:24:02,980 +Hemoglobin Sطبعاً زي ما قلنا المشكلة بتكون إذا كان + +329 +00:24:02,980 --> 00:24:06,920 +SS يعني two genes affected لكن لو كان واحد + +330 +00:24:06,920 --> 00:24:11,040 +affected تبقى عندهم يعني مابيبقاش عندهم أعراض إلا + +331 +00:24:11,040 --> 00:24:15,080 +إذا يعني اتعرضوا لظروف حادة من نقص الأكسجين ممكن + +332 +00:24:15,080 --> 00:24:18,800 +يظهر عندهم mild problem فدول الناس اللي عندهم + +333 +00:24:18,800 --> 00:24:23,220 +trait طبعا يعني بس من رعيهم في ال .. في ال .. يعني + +334 +00:24:23,220 --> 00:24:26,000 +مثلا في الطيران في الصعود إلى الأماكن المرتفعة + +335 +00:24:26,000 --> 00:24:31,370 +لازم يبقى في تزويد لهم بالأكسجين وبالتاليبيعيشوا + +336 +00:24:31,370 --> 00:24:33,890 +حياتهم طبيعي ماعندهم مشاكل المشكلة عند مين عنده + +337 +00:24:33,890 --> 00:24:38,510 +الـ Sickle Cell Anemia هدول هلاقي عندهم Severe + +338 +00:24:38,510 --> 00:24:42,810 +Anemia هلاقي عندهم Target Cells هلاقي عندهم Sickle + +339 +00:24:42,810 --> 00:24:46,250 +Cells هي الـ Target Cell وهي Sickle Cell اللي هي + +340 +00:24:46,250 --> 00:24:49,350 +شكلين زي ما قلنا Filamentous Form and Wood Form + +341 +00:24:49,350 --> 00:24:53,030 +هنلاقي هذا في حالة الـ Sickling هنلاقي عندهم + +342 +00:24:53,030 --> 00:24:58,170 +Nucleated RBCs ليش؟ لأنه الـ Vulnerable Active + +343 +00:24:58,460 --> 00:25:02,100 +هيصير يطلع عندى nucleated RBCs وreticulocyte بشكل + +344 +00:25:02,100 --> 00:25:06,680 +كبير هدول طبعا حلاقة عندهم Hemoglobin A مش موجود + +345 +00:25:06,680 --> 00:25:09,800 +خالص لأن Hemoglobin A شرط في تكوين وجود الـ Beta + +346 +00:25:09,800 --> 00:25:13,520 +-Chain هدول ماعندهم الـ Beta-Chain وإنما حلاقة + +347 +00:25:13,520 --> 00:25:17,880 +عندهم تقريبا من 80 إلى 100% Hemoglobin S مع ارتفاع + +348 +00:25:17,880 --> 00:25:20,540 +في أنواع الـHemoglobin الأخرى اللي مافيها الـBeta + +349 +00:25:20,540 --> 00:25:26,820 +-Chain زي Hemoglobin F هاي + +350 +00:25:26,820 --> 00:25:31,610 +بقولك عن الـTraitهنا جين واحد اللي affected عادة + +351 +00:25:31,610 --> 00:25:34,430 +asymptomatic ممكن أشوف في بعض الأحيان عندهم target + +352 +00:25:34,430 --> 00:25:37,910 +cells نوع anemia or sickle cell عندهم Hemoglobin A + +353 +00:25:37,910 --> 00:25:43,570 +بشكل تقريبا 60% و40% Hemoglobin S طبعا potential + +354 +00:25:43,570 --> 00:25:47,950 +problems of hypoxia يعني ممكن يتعرضوا لبعض المشاكل + +355 +00:25:47,950 --> 00:25:55,810 +في ظروف الhypoxia بس نيجي + +356 +00:25:55,810 --> 00:26:01,340 +لل Hemoglobin C diseaseطبعاً هنا هنلاقي الـ two + +357 +00:26:01,340 --> 00:26:05,180 +genes two beta chain affected وتم استبدال الـ beta + +358 +00:26:05,180 --> 00:26:08,620 +chain تم استبدال الـ glutamic acid فيهم بالليسين + +359 +00:26:08,620 --> 00:26:12,840 +فبنتج عندي Hemoglobin C طبعاً Hemoglobin C هيعمل + +360 +00:26:12,840 --> 00:26:16,000 +crystallization في داخل الخلية ويظهر كblock زي ما + +361 +00:26:16,000 --> 00:26:18,800 +أنتوا شايفين هذا هو في داخل الخلية الـ Hemoglobin + +362 +00:26:18,800 --> 00:26:22,500 +C crystals بنتج عنه mild anemia target cells + +363 +00:26:22,500 --> 00:26:26,880 +intracellular Hemoglobin C Hemoglobin A مش هتلاقي + +364 +00:26:26,880 --> 00:26:33,400 +Hemoglobin Aأكتر من 90% هتلاقي Hemoglobin-C الحالة + +365 +00:26:33,400 --> 00:26:38,260 +التانية أنه يبقى one beta chain affected one gene + +366 +00:26:38,260 --> 00:26:41,820 +في + +367 +00:26:41,820 --> 00:26:45,520 +تعوين الـ beta chain يعطيني Hemoglobin-C هنا + +368 +00:26:45,520 --> 00:26:49,640 +هتلاقيها asymptomatic with no anemia ممكن ألاقي + +369 +00:26:49,640 --> 00:26:53,760 +target cells مش هشوف Hemoglobin-C crystalsحلائق من + +370 +00:26:53,760 --> 00:27:00,120 +تقريبا 60% Hemoglobin-A و40% Hemoglobin-C برضه هنا + +371 +00:27:00,120 --> 00:27:03,160 +حلائق الـ Hemoglobin-A تو Normal و Hemoglobin-F + +372 +00:27:03,160 --> 00:27:07,800 +هيكون برضه Normal نجي + +373 +00:27:07,800 --> 00:27:12,700 +للـ Hemoglobin-S-C Disease هنا بيبقى في عنده الـ + +374 +00:27:12,700 --> 00:27:16,700 +two beta chain affected واحدة فيهم تعطيني + +375 +00:27:16,700 --> 00:27:20,480 +Hemoglobin-S يعني صار فيها substitution مختلفة عن + +376 +00:27:20,480 --> 00:27:28,060 +التانيةالتانية بتعطيني Hemoglobin C طيب هنا هاي + +377 +00:27:28,060 --> 00:27:31,580 +هنا هذا شرح للحالة double heterozygous inherit + +378 +00:27:31,580 --> 00:27:36,280 +sickle gene from one parent and C gene from other + +379 +00:27:36,280 --> 00:27:41,500 +parent both beta chain are abnormal ال lab finding + +380 +00:27:41,500 --> 00:27:44,700 +intermediate in severity هتلاقي ال severity بتاعة + +381 +00:27:44,700 --> 00:27:48,020 +الحالة متوسطة ما بين ال sickle cell أنميا و sickle + +382 +00:27:48,020 --> 00:27:48,600 +cell trait + +383 +00:27:51,930 --> 00:27:57,430 +هنلاقي فيه Target Cells هنلاقي SC Crystals مش + +384 +00:27:57,430 --> 00:28:04,330 +هتلاقي Hemoglobin A هتلاقي 50% Hemoglobin S و 50% + +385 +00:28:04,330 --> 00:28:08,370 +Hemoglobin C نيجي + +386 +00:28:08,370 --> 00:28:13,310 +للـ Acquired Hemolytic Anemia النوع التاني + +387 +00:28:13,310 --> 00:28:16,370 +Acquired Hemolytic Anemia طبعا هنا الخلية بتتكون + +388 +00:28:16,370 --> 00:28:20,580 +صح مش فيها ولا غلطةلكن ظروف خارجية بتأثر على + +389 +00:28:20,580 --> 00:28:23,740 +الخلية بصيرها تكسير زي الـ Immune-mediated + +390 +00:28:23,740 --> 00:28:27,180 +destruction Red Cell Fragmentation Disorder + +391 +00:28:27,180 --> 00:28:32,660 +Acquired Membrane Defects Spleen Defects هذه مشاكل + +392 +00:28:32,660 --> 00:28:38,420 +بتأثر على الخلية و بتقليها تتكسر طبعا هذه الأسباب + +393 +00:28:38,420 --> 00:28:42,500 +يعني ممكن يكون إيش سببها ممكن يكون Immune + +394 +00:28:42,500 --> 00:28:47,390 +Hemolytic Anemia قد تكون Warm أو ColdWarm + +395 +00:28:47,390 --> 00:28:51,330 +Autoimmune Hemolytic Anemia هنا المشكلة أنه بتكون + +396 +00:28:51,330 --> 00:28:55,570 +للـ Self-antigen Auto-antibodies وعادة بتكون Warm + +397 +00:28:55,570 --> 00:29:01,670 +Antibodies من النوع IgG طبعاً هترتبط مع الخلية أو + +398 +00:29:01,670 --> 00:29:04,490 +تعمل sensitization للخلية ممكن يصير complement + +399 +00:29:04,490 --> 00:29:10,310 +activation أو sensitization فهتروح هذه الخلية على + +400 +00:29:10,310 --> 00:29:14,890 +الـSpleen الـSpleen فيها الفاجوسيتس هتعمل لها + +401 +00:29:15,390 --> 00:29:19,050 +Partial Phagocytosis يعني هتعمل بيت لل .. اللي هو + +402 +00:29:19,050 --> 00:29:21,530 +الـ Antibody اللي عانى ال sensitization للخلية + +403 +00:29:21,530 --> 00:29:26,170 +بيصير عندى خلية Spherocyte طبعا بعد هيك هيصير عندى + +404 +00:29:26,170 --> 00:29:31,410 +license لهذه الخلايا قد يكون السبب idiopathic او + +405 +00:29:31,410 --> 00:29:33,950 +secondary نتيجة disease اخر يعني ممكن يكون ال + +406 +00:29:33,950 --> 00:29:37,270 +primary انه فيه auto antibodies بس يعني مش معروف + +407 +00:29:37,270 --> 00:29:40,690 +ايش السبب ممكن يكون نتيجة مرض اخر يزول بزوال + +408 +00:29:40,690 --> 00:29:43,510 +المؤثر هي شكل ال blood film فيه عدد من ال + +409 +00:29:43,510 --> 00:29:48,630 +Spherocyteموجودة في الخلية شايفين كيف؟ ممكن أشوف + +410 +00:29:48,630 --> 00:29:53,290 +فيها abnormality ممكن أشوف polyachromagia ال + +411 +00:29:53,290 --> 00:29:56,330 +polyachromagia دي إيش قولنا عنها؟ هي ال + +412 +00:29:56,330 --> 00:30:02,710 +reticulocyte ال immature erythrocyte طيب ال lab + +413 +00:30:02,710 --> 00:30:06,670 +finding هنلاقي حسب طبعا الحالة moderate to severe + +414 +00:30:06,670 --> 00:30:11,400 +anemiaممكن أشوف الـ Spherocytes ممكن أشوف ال .. + +415 +00:30:11,400 --> 00:30:15,720 +طبعا وين في Spherocyte حاجة الـ MCHC مرتفعة ممكن + +416 +00:30:15,720 --> 00:30:19,340 +أشوف شكل اللي هو الـ Erythropagocytosis يعني أشوف + +417 +00:30:19,340 --> 00:30:23,580 +Erythrocyte صير لها Phagocytosis ليش؟ لأنه هذه الـ + +418 +00:30:23,580 --> 00:30:27,100 +Erythrocyte تحسست بالـ Antibody فبالتالي هتيجي ال + +419 +00:30:27,100 --> 00:30:30,120 +Phagocyte تعمل لها Phagocyte يعني هنا هي عنا واضح + +420 +00:30:30,120 --> 00:30:32,840 +Monocyte عاملة Phagocytosis ل Erythrocyte + +421 +00:30:38,420 --> 00:30:41,480 +طبعاً الـ Blood Film تبعها بشبه الـ Hereditary + +422 +00:30:41,480 --> 00:30:45,520 +Spherocytosis لكن فيه فرق إن الـ Direct + +423 +00:30:45,520 --> 00:30:48,760 +Antiglobulin Test فيها بيكون Positive أو إله اسم + +424 +00:30:48,760 --> 00:30:51,780 +تاني اللي هو الـ Combs Test فده كتير مهم في + +425 +00:30:51,780 --> 00:30:56,620 +التمييز بين أنواع الـ Hemolytic Anemia إذا كان الـ + +426 +00:30:56,620 --> 00:31:00,320 +Combs Test Positive أو ده الـ Test اسمه Positive + +427 +00:31:00,320 --> 00:31:04,370 +هناخد نبذة عنه إن شاء الله في معمل المناعةإذا كان + +428 +00:31:04,370 --> 00:31:07,750 +هذا الفحص positive معنى الكلام إنه هذه autoimmune + +429 +00:31:07,750 --> 00:31:11,750 +hemolytic anemia إيش هو هذا الـDAT أو الكومس بيكشف + +430 +00:31:11,750 --> 00:31:14,910 +عن وجود sensitized cells بيكشف عن وجود خلايا + +431 +00:31:14,910 --> 00:31:21,170 +متحسسة نتيجة أفاعل مناعي طبعا الخلايا لأنها صارت + +432 +00:31:21,170 --> 00:31:24,750 +spherocyte هنلاقي ال osmotic fragility ارتفعت + +433 +00:31:24,750 --> 00:31:29,110 +طالما زادت تكسير هتلاقي ال bilirubin برضه ارتفع + +434 +00:31:29,110 --> 00:31:32,670 +أضف لإنه هتلاقي erythroid hyperplasia + +435 +00:31:36,110 --> 00:31:39,730 +نيجي إلى الـ Cold Autoimmune Hemolytic Anemia هنا + +436 +00:31:39,730 --> 00:31:43,810 +يا بنات، في عندى Antibodies للخلايا لكن هاد الـ + +437 +00:31:43,810 --> 00:31:48,310 +Antibodies من نوع IgM و بتتميز بإنها Cold بمعنى + +438 +00:31:48,310 --> 00:31:52,270 +إنه يعني عادة ما بتشتغل على ال body temperature + +439 +00:31:52,270 --> 00:31:59,370 +لكن ممكن تشتغل على ال room temperature يعني في هذه + +440 +00:31:59,370 --> 00:32:02,310 +الحلقة لو أنا أجيت سحبت عينة تراكتها شوية حتى + +441 +00:32:02,310 --> 00:32:05,150 +أتلاقي العينة عملت Autoagglutination لكن في بعض + +442 +00:32:05,150 --> 00:32:08,080 +الأحيانهتلاقي الـ antibody أو الـ complement + +443 +00:32:08,080 --> 00:32:12,040 +component ارتبطت على سطح الخلايا وعملت complement + +444 +00:32:12,040 --> 00:32:15,720 +activation وحيصير agglutination and lyses by + +445 +00:32:15,720 --> 00:32:20,180 +complement or macrophage ممكن تكون primary أو + +446 +00:32:20,180 --> 00:32:22,060 +secondary لديزييز معين + +447 +00:32:24,660 --> 00:32:29,080 +الـ Lab finding هنلاقي agglutination للـ RBC في + +448 +00:32:29,080 --> 00:32:32,860 +الأطراف زي الأماكن الباردة اللي ممكن تتعرض لدرجة + +449 +00:32:32,860 --> 00:32:38,360 +حرارة باردة زي الأذن الأصابع الأنف هذا طبعا راح + +450 +00:32:38,360 --> 00:32:42,400 +يؤدي إلى tissue damage ممكن يؤدي إلى مضاعفات خطيرة + +451 +00:32:42,400 --> 00:32:47,250 +زي الـ necrosis والجانجرينSeverity varies with + +452 +00:32:47,250 --> 00:32:52,150 +seasons Avoid the cold يعني حدة المرض بتعتمد على + +453 +00:32:52,150 --> 00:32:56,430 +الجو فبالتالي بتزيد في الأجواء الباردة ليش؟ لأن + +454 +00:32:56,430 --> 00:33:00,050 +الـ IGM بارد مش تغير درجة الحرارة الباردة IGM + +455 +00:33:00,050 --> 00:33:03,410 +antibodies causes RBCs agglutination هنشوف + +456 +00:33:03,410 --> 00:33:05,790 +agglutination واضحة للـ blood film لو أنا عملت + +457 +00:33:05,790 --> 00:33:09,270 +blood film هنلاقي reticulocytosis كرد فعلي تكسير + +458 +00:33:09,270 --> 00:33:13,490 +الخلايا بصير تنشيط للـ bone marrowهنلاقي positive + +459 +00:33:13,490 --> 00:33:17,530 +data test detect complement طبعا يا بنات بشكل أساس + +460 +00:33:17,530 --> 00:33:19,970 +الـ IGM هو اللي بعمل activation للـ complement + +461 +00:33:19,970 --> 00:33:23,870 +فبالتالي الـ complement لما بتتنشط ممكن تعمل + +462 +00:33:23,870 --> 00:33:27,010 +sensitization للخلايا فبالتالي بكشف عنها بالـ + +463 +00:33:27,010 --> 00:33:29,830 +direct antoglobulin test أو بالـ Combs test إذا + +464 +00:33:29,830 --> 00:33:33,590 +كنتوا فاكرين توي قلتلكم الـ Combs test بعمل كشف لل + +465 +00:33:33,590 --> 00:33:37,910 +sensitization بالـ antibody وبرضه بعمل كشف لل + +466 +00:33:37,910 --> 00:33:41,290 +sensitization بالـ Combs testبالـ .. بالـ عفو بالـ + +467 +00:33:41,290 --> 00:33:44,110 +complement هلاقيت إذا صار الـ sensitization بالـ + +468 +00:33:44,110 --> 00:33:47,070 +complement بفهم إنه هذا ال antibody IgM لأن هو + +469 +00:33:47,070 --> 00:33:50,190 +اللي بعمل أغلبا activation لل complement إذا صار + +470 +00:33:50,190 --> 00:33:53,410 +ال sensitization ب antibody فبفهم إنه IgG + +471 +00:34:09,500 --> 00:34:17,740 +هنا أنا طبعا بروح بنقل وحة الدم وحة الدم هذه هيكون + +472 +00:34:17,740 --> 00:34:23,840 +فيها بعض الـ Antigens الـ Antigens هذه لن تتوافق + +473 +00:34:23,840 --> 00:34:26,720 +مع ال patient يعني ال patient عنده antibodies لها + +474 +00:34:26,720 --> 00:34:31,200 +يعني ال recipient عنده antibody X ونقلتله Antigen + +475 +00:34:31,200 --> 00:34:35,920 +X هيصير أكيد reaction وبالتالي هيصير تكسير لخلايا + +476 +00:34:35,920 --> 00:34:40,050 +ال donorأسوأ واحد فيهم اللي هو الـ ABO + +477 +00:34:40,050 --> 00:34:43,730 +Incompatibility طبعا أنتوا ما بتعرفوش غيره في عندي + +478 +00:34:43,730 --> 00:34:46,450 +أنواع تانية من الـ Incompatibility هتاخدوها في بنك + +479 +00:34:46,450 --> 00:34:51,510 +الذمب لكن بنحكي أكثر واحد بيعمل مشاكل اللي هو الـ + +480 +00:34:51,510 --> 00:34:55,210 +ABO Blood Group System بيعمل Intravascular + +481 +00:34:55,210 --> 00:35:00,730 +Hemolysis ليش؟ لأن هنا ال reaction بيكون strong + +482 +00:35:01,160 --> 00:35:04,080 +والـ Antibody is strong فبتعمل Intravascular + +483 +00:35:04,080 --> 00:35:07,140 +Hemolysis نتيجة الـ Complement Activation يعني ما + +484 +00:35:07,140 --> 00:35:10,120 +بيستنى الـ Antibody يعمل Synthetization ويروح + +485 +00:35:10,120 --> 00:35:14,260 +هالسبلين لسه و هناك يصير له تكسير زي الـ IgG ثم + +486 +00:35:14,260 --> 00:35:18,260 +مباشرة هيصير له تكسير في الـ Peripheral Blood فيما + +487 +00:35:18,260 --> 00:35:21,500 +يسمى الـ Intravascular Hemolysis طبعا ممكن يعمل + +488 +00:35:21,500 --> 00:35:25,180 +بلوك للنفرون للمصافر الكدنى الـ Antigen Antibody + +489 +00:35:25,180 --> 00:35:28,300 +Complexes وممكن يكون Alive with Retaining + +490 +00:35:32,370 --> 00:35:37,870 +نيجي للـHemolytic Disease of the newborn طبعاً هذه + +491 +00:35:37,870 --> 00:35:42,190 +بنات يعني أنا دائما بذكركم فيه اللي هو عامل Rhesus + +492 +00:35:42,190 --> 00:35:46,490 +إذا كان فيش توافق بين فصيلة الأم والطفل إيش ممكن + +493 +00:35:46,490 --> 00:35:52,450 +يصير؟ ممكن عند قطع الحبل السري تنتقل بعض الخلايا + +494 +00:35:52,450 --> 00:35:57,330 +اللي قد تعتبر فيها Antigens غريبة إلى الأم احنا + +495 +00:35:57,330 --> 00:36:03,830 +دايما المثال الشائع عندنااللي هو الـ Rh صح؟ هو في + +496 +00:36:03,830 --> 00:36:08,150 +أشياء تانية لكن الأكتر شيوعا الـ Rh هلاقيت عند قطع + +497 +00:36:08,150 --> 00:36:11,530 +الحبل السري إذا كان الطفل موجب و الأم negative + +498 +00:36:11,530 --> 00:36:17,210 +هتنتقل خلايا موجبة إلى الأم وبالتالي هتعتبر خلايا + +499 +00:36:17,210 --> 00:36:21,570 +غريبة فهيتكونلها antibodies فلاقيت الأم اتكون + +500 +00:36:21,570 --> 00:36:26,810 +عندها anti نقول مجازن Anti-D عن الـ Rh لأن الـ Rh + +501 +00:36:26,810 --> 00:36:30,640 +مجموعة من الانتجنات أهم واحد فيهم الـ Dفالأم حيصير + +502 +00:36:30,640 --> 00:36:33,900 +عندها Anti-D فلاقيت الـ Anti-D هذا مش هيأذى الطفل + +503 +00:36:33,900 --> 00:36:36,700 +الأول لكن لو حملة مرة تانية بطفل عنده الـ D + +504 +00:36:36,700 --> 00:36:40,600 +-Antigen أو الـ Rh Positive هينتقل الـ Anti-D + +505 +00:36:40,600 --> 00:36:46,280 +للطفل ويعمل تكسير للخلايا تبعته فهينشق Hemolytic + +506 +00:36:46,280 --> 00:36:50,340 +Disease of a Newborn وبتتميز ذات الـ Rh بأنها + +507 +00:36:50,340 --> 00:36:55,320 +بتعمل Severe Anemia وحنلاقي فيها Nucleated R + +508 +00:36:55,320 --> 00:36:59,770 +-Pieces تمام؟طبعاً أنتوا عارفين إيش علاجها إنه + +509 +00:36:59,770 --> 00:37:04,870 +إحنا بنعطي الأم بمجرد ما تولد اللي هو إبرة إيش + +510 +00:37:04,870 --> 00:37:11,990 +الإبرة هذه؟ هي عبارة عن Anti-D جاهز بحيث إنه أي + +511 +00:37:11,990 --> 00:37:15,790 +خلية أي خلية تمرق من الطفل للأم تم تكسيرها مباشرة + +512 +00:37:15,790 --> 00:37:20,250 +قبل ما يتكونلها antibodies طيب + +513 +00:37:20,250 --> 00:37:24,310 +الـHemolytic Disease due to ABO incompatibility + +514 +00:37:24,310 --> 00:37:27,690 +يعنيفي عندنا Hemolytic Disease بس مش نتيجة الـ RH + +515 +00:37:27,690 --> 00:37:34,090 +نتيجة الـ ABO هذه أمتى بتصير؟ بتصير إذا كانت الأم + +516 +00:37:34,090 --> 00:37:38,590 +فصلتها O إذا كانت الأم طبعا مش دايما هذه يعني مش + +517 +00:37:38,590 --> 00:37:43,450 +شائعة الحدوث إذا كانت الأم فصلتها O هيكون عندها + +518 +00:37:43,450 --> 00:37:49,550 +Anti-A و Anti-B و هدول Anti-A و Anti-B ممكن فيهم + +519 +00:37:49,550 --> 00:37:52,370 +IgG ممكن يخترقوا الـ placenta يعني ممكن يخترقوا + +520 +00:37:52,370 --> 00:37:56,080 +المشيمة أو يوصلوا للطفلففرضًا كان الطفل فصيلته A + +521 +00:37:56,080 --> 00:38:00,580 +أو B ووصله من الأم Anti-A أو Anti-B ممكن يصير عنده + +522 +00:38:00,580 --> 00:38:04,020 +Mild Hemolysis بس ما بتطور لأنميا وبنشوف عنده + +523 +00:38:04,020 --> 00:38:08,700 +Serocytes هذا مش كتير common لأن الـ Rh أنتجنز + +524 +00:38:08,700 --> 00:38:12,480 +عفوا الـ ABO أنتجنز نفسها ما بتكونش لسه مكتملة + +525 +00:38:12,480 --> 00:38:15,780 +بشكل كافي عند الطفل انها تعمل reaction على خلاف + +526 +00:38:15,780 --> 00:38:17,760 +الـ Rh اللي هو الأكثر شيء عندي + +527 +00:38:21,550 --> 00:38:26,190 +نجي للـ Hemolytic Anemia due to trauma طبعا أنه + +528 +00:38:26,190 --> 00:38:29,990 +Hemolytic Anemia ساقنة يعني صار تعرض لـ External + +529 +00:38:29,990 --> 00:38:35,390 +trauma أفرت على الخلايا فعملت لها تكسير + +530 +00:38:35,390 --> 00:38:41,390 +Fragmentation Syndrome ممكن تكون mechanical زي + +531 +00:38:41,390 --> 00:38:45,970 +الناس اللي هي بتركب صممات قلب صناعية مرور الخلايا + +532 +00:38:45,970 --> 00:38:50,180 +عبر الصمام هذا ممكن يعمل فيها damageأو حالة + +533 +00:38:50,180 --> 00:38:53,620 +بيسموها microangiopathic microangiopathic تبقى ال + +534 +00:38:53,620 --> 00:39:00,460 +blood vessels اكتر دقيقة دقيقة جدا طبعا هذه ممكن + +535 +00:39:00,460 --> 00:39:04,900 +يصير تكثير للخلايا وممكن تتطور لحالات DIC و + +536 +00:39:04,900 --> 00:39:07,760 +bleeding disseminated intravascular coagulation + +537 +00:39:08,750 --> 00:39:13,750 +مارش مغلوبينيوريا طبعا هذه تيجي للعدائين اللي + +538 +00:39:13,750 --> 00:39:16,890 +بيجروا مسافات طويلة ممكن يصير عندهم تكسير في ال + +539 +00:39:16,890 --> 00:39:21,030 +blood نتيجة الحركة السريعة والاحتكاك المفاصل طبعا + +540 +00:39:21,030 --> 00:39:26,450 +هذه طبعا بتزول بزوال المؤثر ممكن نشوف فيها + +541 +00:39:26,450 --> 00:39:31,830 +مغلوبينيوريا نيجي + +542 +00:39:31,830 --> 00:39:35,830 +لل hemolytic anemia اللي شاية من infectious agents + +543 +00:39:35,830 --> 00:39:41,440 +and bearsطبعا هنا الانيميا يعني بعض الأشياء اللي + +544 +00:39:41,440 --> 00:39:45,180 +ممكن تعمل infection بعض ال agent ممكن تعمل عندي + +545 +00:39:45,180 --> 00:39:51,560 +انيميا أو تكثير بال RBC أو واحد تعرض لحروق أو تعرض + +546 +00:39:51,560 --> 00:39:56,020 +لحروق طبعا هنا الانيميا حسب الشدة بتكون حسب المؤثر + +547 +00:39:56,020 --> 00:39:59,340 +اللي تعرضله هذا الشخص هي ممكن ألاقي Schistocyte أو + +548 +00:39:59,340 --> 00:40:04,960 +Spherocyte في blood smearعنا من الأمثلة بعض + +549 +00:40:04,960 --> 00:40:08,720 +البروسايتز زي الملاريا البروسايتز هذه هتعطيني + +550 +00:40:08,720 --> 00:40:12,400 +lightening toxin ممكن تعمل license لل RBCs أو + +551 +00:40:12,400 --> 00:40:14,900 +cause direct damage to red cell membrane هلأ هي + +552 +00:40:14,900 --> 00:40:20,200 +خلال فترة التكاثر تبعتها الملاريا أنه بتتكاثر في + +553 +00:40:20,200 --> 00:40:23,100 +داخل الارترسايت و بعدين بيصير license لل RBCs عشان + +554 +00:40:23,100 --> 00:40:26,720 +ينطلق هذا يطلع هذا البروسايتز اللي اتكاثر في قلب + +555 +00:40:26,720 --> 00:40:29,810 +الارترسايتزفإما عن طريق الـ «توكسين» اللي بتفرزها + +556 +00:40:29,810 --> 00:40:34,990 +أو عن طريق التكسيق أو الـ «license» المباشر للـ + +557 +00:40:34,990 --> 00:40:38,270 +Cell Membrane إيه في حالات الـ Clostridium برضه + +558 +00:40:38,270 --> 00:40:40,670 +اللي بتعمل «توكسين»؟ حلائق «شيستوسايت» وحلائق + +559 +00:40:40,670 --> 00:40:46,010 +«سبيروسايتروز» هيك + +560 +00:40:46,010 --> 00:40:50,530 +نكون خلصنا الأنميا يعطيكوا ألف عافية بعد هيك راح + +561 +00:40:50,530 --> 00:40:55,070 +ننتقل لمرحلة تانية في الأنميا اللي هي أنا بعتبرها + +562 +00:40:55,070 --> 00:40:58,250 +الأهموهي مرحلة الـ Case Studies + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/U5ZlKzo79yw_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/U5ZlKzo79yw_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..bc5690a95061de9b4da22ed55ec43e49b42bdd65 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/U5ZlKzo79yw_postprocess.srt @@ -0,0 +1,1592 @@ +1 +00:00:15,420 --> 00:00:18,420 +نجي للجزئية الرابعة في الـDiagnosis المهمة في + +2 +00:00:18,420 --> 00:00:20,140 +الـDiagnosis اللي هي جزئية + +3 +00:00:20,140 --> 00:00:24,120 +الـCytogeneticsCytogenetic studies ممكن الآن + +4 +00:00:24,120 --> 00:00:28,840 +تستخدم في الـDiagnosis لحالات من حالات + +5 +00:00:28,840 --> 00:00:32,260 +الـHematologic Malignancies وبرضه للتنبؤ + +6 +00:00:32,260 --> 00:00:35,700 +بالـPrognosis يعني ممكن بناء على الـAbnormality + +7 +00:00:35,700 --> 00:00:40,240 +اللي صايرة نتوقع إيش الـPrognosis في كتير أنواع من + +8 +00:00:40,240 --> 00:00:44,410 +أنواع اللوكيميا والانفامةتتميز بوجود Specific + +9 +00:00:44,410 --> 00:00:48,230 +Chromosomal Abnormalities يعني فيه Abnormality إذا + +10 +00:00:48,230 --> 00:00:51,430 +لاقناها بنتوقع هذا النوع من اللوكيميا أو يمكن يكون + +11 +00:00:51,430 --> 00:00:54,790 +الـDiagnosis إنه عندي هذا النوع من اللوكيميا + +12 +00:00:54,790 --> 00:00:58,910 +Including Specific Translocation and Anibloidy + +13 +00:00:58,910 --> 00:01:03,030 +ممكن يكون على شكل Translocation …Chromosomal + +14 +00:01:03,030 --> 00:01:08,890 +Translocation أو على شكل Anibloidy اللي هو زيادة + +15 +00:01:08,890 --> 00:01:12,720 +أو تغير أكتر أو نقصان في عدد الكروموزوماتThe + +16 +00:01:12,720 --> 00:01:15,820 +specific type of malignancy can be identified + +17 +00:01:15,820 --> 00:01:19,620 +based on the specific abnormality or translocation + +18 +00:01:19,620 --> 00:01:25,080 +يعني احنا ممكن نتنبأ بنوع الـ Malignancy أو نشخصها + +19 +00:01:25,080 --> 00:01:28,260 +بناء على الـ abnormality أو الـ translocation اللي + +20 +00:01:28,260 --> 00:01:31,890 +صاريعني عندنا مثلًا دائمًا لما بلاقي الـ + +21 +00:01:31,890 --> 00:01:36,090 +Philadelphia chromosome بتوقع إنه في حالة CML أو + +22 +00:01:36,090 --> 00:01:39,670 +ممكن تتطور حالة CML يعني التنتين هدول مثلًا + +23 +00:01:39,670 --> 00:01:43,170 +مرتبطين ببعض فبالتالي بناءً على الـ Translocation + +24 +00:01:43,170 --> 00:01:47,270 +أنا ممكن أعرف أو أشخص نوع معين من أنواع الـ + +25 +00:01:47,270 --> 00:01:52,270 +Malignancy في خلايا الدمThis may be identified by + +26 +00:01:52,270 --> 00:01:55,790 +ممكن هذه الـ Abnormalities أحنا نعملها عن طريق الـ + +27 +00:01:55,790 --> 00:02:00,650 +Karyotyping عشان نشوف أعداد الكرومزومات أو فحوصات + +28 +00:02:00,650 --> 00:02:06,850 +يعني الـ DNA المختلفة طبعا يعني في فحوصات متعددة + +29 +00:02:06,850 --> 00:02:10,370 +حسب نوع الخلل اللي أنا بدي أكشف عنه ممكن أختار + +30 +00:02:10,370 --> 00:02:14,780 +الفحص المناسبعادة ملاحظة مهمة إذا كان الـ + +31 +00:02:14,780 --> 00:02:18,460 +Karyotyping normal بنتوقع إن الحالة يكون الـ + +32 +00:02:18,460 --> 00:02:21,640 +Habitat Prognosis يعني كل ما كان الـ Karyotyping + +33 +00:02:21,640 --> 00:02:24,720 +فيه defect أو فيه مشكلة فهذا بالتالي على الـ + +34 +00:02:24,720 --> 00:02:27,940 +Translocation between two chromosomes اللي هو + +35 +00:02:27,940 --> 00:02:32,400 +كرمزوم 7 و كرمزوم 8 صار تبادل لقطعتين في الـ long + +36 +00:02:32,400 --> 00:02:37,240 +arm فنشأ عندي كرمزومات حصل فيها Translocation يعني + +37 +00:02:37,240 --> 00:02:42,680 +كل واحد ماخد رزق من الكرمزوم التانيطبعاً هذا الـ + +38 +00:02:42,680 --> 00:02:45,160 +Karyotyping بيعطينا صورة الـ Karyotyping كيف + +39 +00:02:45,160 --> 00:02:48,540 +الكرمزومات لما احنا بنفرزها و بنبلش نتعرف عليها و + +40 +00:02:48,540 --> 00:02:55,600 +نعيدها طيب نيجي لبعض أنواع الـ Abnormalities الـ + +41 +00:02:55,600 --> 00:02:59,300 +Common في أنواع معينة من اللوكينيا يعني على سبيل + +42 +00:02:59,300 --> 00:03:07,520 +المثال الـ ALL شائع فيها Translocation 9.22 لـ Pre + +43 +00:03:07,520 --> 00:03:13,620 +-ALL Translocation 1.19عادةً هذه بتكون موجودة في + +44 +00:03:13,620 --> 00:03:18,840 +الـ L1 هذه في L1 و L2 الـ PALL ممكن يصير فيها + +45 +00:03:18,840 --> 00:03:25,060 +Translocation ما بين 8 و 14، 8 و 22، 2 و 8 يعني + +46 +00:03:25,060 --> 00:03:28,240 +تمانية هنا مشترك فيهم ممكن يعمل Translocation يصير + +47 +00:03:28,240 --> 00:03:32,940 +Translocation بينه وبين 2 أو 22 أو 14 في الـ + +48 +00:03:32,940 --> 00:03:37,460 +Parietal lymphoma في الـ L3 في الـ TALL ممكن يصير + +49 +00:03:37,460 --> 00:03:43,660 +Translocation 11 و 14 في L1 و L2الـ AML الـ AML + +50 +00:03:43,660 --> 00:03:47,860 +بيصير فيها عادة حسب يعني عندنا مثلا في الـ M2 ممكن + +51 +00:03:47,860 --> 00:03:52,800 +يصي ألاقي Translocation 821 في الـ M3 وهذا شائع + +52 +00:03:52,800 --> 00:03:56,860 +جدا اللي هو Acute Bromelocyte Leukemia + +53 +00:03:56,860 --> 00:04:04,100 +Translocation 1517 الـ M7 بيصير Deletion فيه + +54 +00:04:04,100 --> 00:04:09,980 +كرمزوم 11 الـ M4 Inversion 16 Translocation 1616 + +55 +00:04:09,980 --> 00:04:14,910 +M6Translocation 8 إلى 16 أكتر واحد شيوعاً وبدي + +56 +00:04:14,910 --> 00:04:19,170 +ياكم تعرفوا اللي هو بيصير في الـAML عادة الـAML + +57 +00:04:19,170 --> 00:04:27,130 +شهيرة بالـ15-17 Translocation اللي + +58 +00:04:27,130 --> 00:04:31,030 +هي الـM3 يعني أقصد الـAML M3 + +59 +00:04:37,390 --> 00:04:42,190 +طيب هنا برضه يعني بعض أنواع اللوكيميا والممكن أش + +60 +00:04:42,190 --> 00:04:47,110 +اللي translocations اللي بتصير فيها لو أجينا نشوف + +61 +00:04:47,110 --> 00:04:50,590 +يعني كل نوع اللوكيميا موجودة حكيلك أش ممكن يصير + +62 +00:04:50,590 --> 00:04:52,470 +فيها inversion أو translocation + +63 +00:06:24,390 --> 00:06:28,690 +طيب، الآن إيش علاقة الكرموزومة الـ Abnormalities + +64 +00:06:28,690 --> 00:06:34,970 +بالـ Prognosis في حالات الـ ALL؟ هلقيت بقولّك لو + +65 +00:06:34,970 --> 00:06:41,070 +كان الـ Karyotyping Normal وفي عندي Hyperploidي + +66 +00:06:41,070 --> 00:06:44,310 +يعني زيادة في عدد الكرموزومات الـ Prognosis بيكون + +67 +00:06:44,310 --> 00:06:49,330 +أفضل لكن الـ Pore Prognosis لو كان Translocation + +68 +00:06:49,330 --> 00:06:56,700 +814 أو 411very poor prognosis سيئ جداً + +69 +00:06:56,700 --> 00:07:02,300 +translocation اللي هو 922 هذه بتعتبر very poor + +70 +00:07:02,300 --> 00:07:07,480 +prognosis بعض + +71 +00:07:07,480 --> 00:07:11,000 +الكرمزومة الـ abnormalities في الـ AML و علاقتها + +72 +00:07:11,000 --> 00:07:16,220 +بالـ prognosis الآن الـ good prognosis الـ good + +73 +00:07:16,220 --> 00:07:20,080 +prognosis بيحصل لو كان في عندي translocation 8 إلى + +74 +00:07:20,080 --> 00:07:26,130 +21أو 15 إلى 17 أو صار Inversion 16 Intermediate زي + +75 +00:07:26,130 --> 00:07:32,430 +Anormal Karyotyping أو زيادة في بعض الكرمزومات زي + +76 +00:07:32,430 --> 00:07:35,830 +كرمزوم 8، 21، 22 أو Deletion في الـLong Arm + +77 +00:07:35,830 --> 00:07:39,870 +للكرمزوم 7 أو Deletion في الـLong Arm للكرمزوم 9 + +78 +00:07:39,870 --> 00:07:45,930 +بعد Prognosis إذا كان فيه نقص في كرمزوم 5 أو 7 إذا + +79 +00:07:45,930 --> 00:07:49,150 +كان فيه Deletion في الـLong Arm لكرمزوم 5 أو + +80 +00:07:49,150 --> 00:07:53,950 +AbnormalLong arm لـChromosome 3 Complex + +81 +00:07:53,950 --> 00:07:58,030 +stereotyping يعني إذا كان في عندى أكتر من تلاتة + +82 +00:07:58,030 --> 00:08:01,030 +إلى خمسة abnormality بيبقى ال diagnosis هنا very + +83 +00:08:01,030 --> 00:08:05,630 +bad طبعا هدول مش للحفظ دعوني ال ALL أنا بدي أقول + +84 +00:08:05,630 --> 00:08:10,050 +تحفظوهم بس هدول لأ الآن ال path of physiology of + +85 +00:08:10,050 --> 00:08:15,170 +acute leukemia إيش بتصير؟ طبعا بتصير ال mortality + +86 +00:08:15,170 --> 00:08:20,010 +و ال morbidity من تلت أشياء رئيسية أول حاجةالـ + +87 +00:08:20,010 --> 00:08:25,010 +hemobiosis بشكل عام صار فيه خلل فبالتالي مافيش + +88 +00:08:25,010 --> 00:08:29,430 +normal blood cell number or function يعني بتفقد + +89 +00:08:29,430 --> 00:08:31,910 +وظيفتها و بيبقى اللي فيه عدد طبيعي يعني white + +90 +00:08:31,910 --> 00:08:35,170 +pieces مش هتكون موجودة الـ normal بشكل كافي + +91 +00:08:35,170 --> 00:08:38,630 +فبالتالي هتأخذه الميكروفات الجسم البلاتلتز هيصير + +92 +00:08:38,630 --> 00:08:41,710 +فيها deficiency فهيصير bleeding RBCs برضه هيكون + +93 +00:08:41,710 --> 00:08:46,130 +فيها نخص فهيصير anemiaالشغلة التانية أن هذه + +94 +00:08:46,130 --> 00:08:50,710 +الخلايا كالـ Malignant هتخزوا الـ vital organs في + +95 +00:08:50,710 --> 00:08:54,510 +الجسم وتؤثر على الـ function بتاعتها كمان شغلة + +96 +00:08:54,510 --> 00:08:57,470 +ممكن يصير systemic disturbances shown by metabolic + +97 +00:08:57,470 --> 00:09:00,970 +imbalance هيصير خلل في الميتابوليزم نتيجة وجود + +98 +00:09:00,970 --> 00:09:05,270 +الخلايا هذه وبعض المكونات اللي ممكن الخلايا هذه + +99 +00:09:05,270 --> 00:09:09,750 +تفرزها أو تكونها هتأثر علىبداية Deficiency of + +100 +00:09:09,750 --> 00:09:12,690 +normal blood cell number or function زي ما حكينا + +101 +00:09:12,690 --> 00:09:16,570 +هيصير خلال في الـ White BCs يؤدي لإنفكشن في الـ + +102 +00:09:16,570 --> 00:09:18,970 +Blatulate يؤدي لهيموراج في الـRBCs هيؤدي لأنمي + +103 +00:09:18,970 --> 00:09:23,370 +Infiltration of tissue or organs الشغل التاني أن + +104 +00:09:23,370 --> 00:09:27,570 +الخلايا هذه تغذو بعض ال organs فممكن تعمل بالتالي + +105 +00:09:27,570 --> 00:09:30,370 +enlargement للـ liver للـspleen للـ lymph nodes + +106 +00:09:30,370 --> 00:09:35,500 +ممكن تعمل gum hypertrophyممكن تعمل ألم شديد في + +107 +00:09:35,500 --> 00:09:38,720 +العظام أخر أرغن ممكن يوصل لها زي الـ Central + +108 +00:09:38,720 --> 00:09:43,320 +Nervous System والسكن والتستس وأي أرغن ممكن تصيح + +109 +00:09:43,320 --> 00:09:48,380 +صورة على الجم Hypertrophy في + +110 +00:09:48,380 --> 00:09:52,380 +الـ AML أنفار تكون فيها Xenophilic cells وبرضه الـ + +111 +00:09:52,380 --> 00:09:55,420 +Monocyte زي ما انتوا عارفين ممكن تعمل Infiltration + +112 +00:09:55,420 --> 00:09:58,420 +من صفاتها الـ Monocytechelochemistry أنها بتعمل + +113 +00:09:58,420 --> 00:10:01,600 +Infiltration في الأنسجة من الأماكن اللي بيصير فيها + +114 +00:10:01,600 --> 00:10:07,990 +Infiltration الجمكلوراما تلون في الجلد زي ما انتوا + +115 +00:10:07,990 --> 00:10:14,970 +شايفين تلون في الجلد طيب + +116 +00:10:14,970 --> 00:10:20,830 +نيجي للـ Leukostasis اش Leukostasis هذه؟ ممكن الـ + +117 +00:10:20,830 --> 00:10:26,670 +Blast Cells هذه تعمل تتجمع مع بعض وتروح وقفة في + +118 +00:10:26,670 --> 00:10:29,630 +الـ microcirculation في الـ circulations الدقيقة + +119 +00:10:30,490 --> 00:10:34,130 +فبتعمل زي Impulse إيش يعني Impulse؟ زي جلطة صغيرة + +120 +00:10:34,130 --> 00:10:38,090 +بس من الـ Blast طبعاً هذه هتأثر على الـ Perfusion + +121 +00:10:38,090 --> 00:10:41,110 +للعضو هتأثر على كمية الـ Blood اللي واصلة للعضو + +122 +00:10:41,110 --> 00:10:45,250 +إيش هينتج عنه؟ ممكن لو مثلا قلنا في الـ Lung ممكن + +123 +00:10:45,250 --> 00:10:50,250 +يصير Hypoxemia Bulmonary Infiltrate هتنتقل هذه + +124 +00:10:50,250 --> 00:10:54,670 +للخلايا وممكن تنتشر في الـ Lung ممكن يصير Hypoxia + +125 +00:10:54,670 --> 00:10:57,210 +في الـ Lung الـ Central Nervous System ممكن تعمل + +126 +00:10:57,210 --> 00:11:00,620 +Stroke يعني ممكن إيش تعمل؟ اتسددأحد الشرايين + +127 +00:11:00,620 --> 00:11:06,460 +الرئيسية المغذية للدماغ وتعمل جلطة دماغية طيب ها + +128 +00:11:06,460 --> 00:11:09,260 +دي بقولك إنها بس بتبين إذا كانت ال «white pieces» + +129 +00:11:09,260 --> 00:11:11,240 +أو بتصير إذا كانت ال «white pieces» عددها فوق + +130 +00:11:11,240 --> 00:11:14,940 +الخمسين ألف «hyperleukocytosis» إذا كان عدد ال + +131 +00:11:14,940 --> 00:11:20,140 +«white pieces» فوق الخمسين ألف من الأشياء السيئة + +132 +00:11:20,140 --> 00:11:24,540 +اللي ممكن تعملها اللوكيميا خلال فترة العلاج أنه + +133 +00:11:24,540 --> 00:11:29,510 +بتدور إليها على sanctuary siteإيش يعني sanctuary + +134 +00:11:29,510 --> 00:11:35,590 +site؟ مكان أو ملاذ آمن الآن خلال فترة العلاج اللي + +135 +00:11:35,590 --> 00:11:39,530 +بياخده المريض في أماكن ممكن ما يوصل لها هذا العلاج + +136 +00:11:39,530 --> 00:11:43,210 +اللي هو الـ Cytotoxic Drug العلاج الكيموي والأدوية + +137 +00:11:43,210 --> 00:11:47,610 +هذه في أماكن ممكن ما توصل لها زي ash زي الـ Testis + +138 +00:11:47,610 --> 00:11:50,890 +والـ Meninges هذه الأماكن ما بوصل لها العلاج + +139 +00:11:50,890 --> 00:11:57,810 +فبالتالي الخلايا بتروح و بتختفي هناك بتقعد في هذا + +140 +00:11:57,810 --> 00:12:01,150 +المكانإذا كانت موجودة الخلايا وعمل Infiltration في + +141 +00:12:01,150 --> 00:12:05,970 +هذا المكان مش راح يوصل لها العلاج الآن المريض أخد + +142 +00:12:05,970 --> 00:12:10,430 +العلاج وخلص واتعافى الخلايا دي لازالت موجودة ممكن + +143 +00:12:10,430 --> 00:12:15,330 +تطلع وتعمل Relapse تعمل عودة للمرض وهذه شائعة في + +144 +00:12:15,330 --> 00:12:18,710 +الـ Childhood ALL في حالات الـ Acute Lymphoblastic + +145 +00:12:18,710 --> 00:12:22,430 +Disease السبب التالت من الأسباب اللي بتكون Harmful + +146 +00:12:22,430 --> 00:12:24,790 +في اللوكيميا وتؤدي إلى الوفاة اللي هي الـ + +147 +00:12:24,790 --> 00:12:29,600 +Metabolic Disturbancesإيش اللي ممكن يصير في حالات + +148 +00:12:29,600 --> 00:12:33,040 +اللوكيميا؟ أول حاجة الـ Hyponatremia إيش يعني + +149 +00:12:33,040 --> 00:12:36,600 +Hyponatremia نقص الصوديوم؟ طب من إيش بيصير نقص + +150 +00:12:36,600 --> 00:12:40,580 +الصوديوم؟ نقص الصوديوم بيجي في الحالات اللي بتبقى + +151 +00:12:40,580 --> 00:12:44,750 +فيها Myeloblast اللي هي الـAML عادةلأن الـ + +152 +00:12:44,750 --> 00:12:49,150 +Homoloblast بتفرز هرمون Vasopressin-like هرمون + +153 +00:12:49,150 --> 00:12:53,790 +شبيه بالـ Vasopressin هرمون هذا الهرمون بيؤدي إلى + +154 +00:12:53,790 --> 00:12:58,170 +هروب الكالسيوم عبر الكدن عفواً الـ Sodium من الكدن + +155 +00:12:58,170 --> 00:13:03,350 +فطبعاً هذا يؤدي إلى هروبه في الكدن هيؤدي إلى نقصه + +156 +00:13:03,350 --> 00:13:06,090 +في الـ circulation عشان هيك بتصير أنها حالة + +157 +00:13:06,090 --> 00:13:10,010 +Hyponatremia الشغل التاني Hypokalemia نقص + +158 +00:13:10,010 --> 00:13:13,950 +البوتاسيامنقص البوتاثين بيصير حال عادة في حالات + +159 +00:13:13,950 --> 00:13:19,010 +الـ M4 والـ M5 هي ممكن يكون جاي نتيجة خلل برضه في + +160 +00:13:19,010 --> 00:13:23,310 +الـ kidney طيب، شغلة رابعة، ارتفاع الـ Uric Acid + +161 +00:13:23,310 --> 00:13:26,670 +طب من إيش بيجي ارتفاع الـ Uric Acid؟ طب أن إحنا + +162 +00:13:26,670 --> 00:13:29,290 +عارفين الـ blood cells اللي بتكون عادة بتكون + +163 +00:13:29,290 --> 00:13:33,250 +fragile فممكن يتصيرلها spontaneous slices الـ + +164 +00:13:33,250 --> 00:13:35,790 +spontaneous slices هذه هيفرز كمية كبيرة من + +165 +00:13:35,790 --> 00:13:39,550 +البيورين في الـ circulationالكمية الكبيرة هذه ممكن + +166 +00:13:39,550 --> 00:13:43,150 +الكدني طبعاً هي هتتحول لـ Uric Acid الـ Uric Acid + +167 +00:13:43,150 --> 00:13:48,730 +هيشكل لودي كتير كبير على الكدني مش هتقدر تتخلص منه + +168 +00:13:48,730 --> 00:13:51,710 +بالشكل الكافي خاصة إذا كان أساساً فيه خلل في + +169 +00:13:51,710 --> 00:13:55,210 +الكيلية فبالتالي ممكن يكون خطير لدرجة إن الوريد + +170 +00:13:55,210 --> 00:14:01,160 +يحتاج غسيل كيلة نتيجة الشغلة هذهوبتضاعف المشكلة مع + +171 +00:14:01,160 --> 00:14:03,800 +الـ cytotoxic drugs الـ cytotoxic drugs اللي + +172 +00:14:03,800 --> 00:14:07,140 +بياخدوها المرضى هدال أول حاجة بتزيد ال license + +173 +00:14:07,140 --> 00:14:10,800 +للخلايا لأن هي الـ cytotoxic drugs هتموت الخلايا + +174 +00:14:10,800 --> 00:14:15,880 +اللي هي السرطانية تكسير الخلايا السرطانية هيزيد + +175 +00:14:15,880 --> 00:14:19,940 +الإفراز لبيورين وبالتالي هيزود اليوريك أسد + +176 +00:14:19,940 --> 00:14:24,480 +بالإضافة لأنه هيعطل النفران لأن الـ cytotoxic drug + +177 +00:14:24,480 --> 00:14:28,240 +برضه nefrotoxicفهيضاعف المشكلة اللي جاية من تكسير + +178 +00:14:28,240 --> 00:14:31,820 +الخلايا حتى لو كانت المشكلة بسيطة وجود الـ + +179 +00:14:31,820 --> 00:14:36,160 +Cytotoxic Drug وتأثيره على النفران تأثير سلبي + +180 +00:14:36,160 --> 00:14:41,940 +هيؤثر ويزود المشكلة ويوصلها إلى مراحل صعبة ممكن + +181 +00:14:41,940 --> 00:14:45,900 +تحتاج لـ Dialysis طيب، يعني بعد ما خلصنا الـ Acute + +182 +00:14:45,900 --> 00:14:49,340 +Leukemia بدنا نلخص الكلام اللي حكيناه في بعض + +183 +00:14:49,340 --> 00:14:53,500 +النقاط المهمة اللي بتنزمني في الـ Diagnosisأول + +184 +00:14:53,500 --> 00:14:57,380 +حاجة في الـ Acute Leukemia الـ Lab Finding أول + +185 +00:14:57,380 --> 00:15:04,320 +حاجة الـ White BCs عادة elevated بس لكن ممكن تكون + +186 +00:15:04,320 --> 00:15:08,420 +Normal أو لأ مش شرط إنها تبقى دايماً عالية ممكن + +187 +00:15:08,420 --> 00:15:11,660 +أشوف Blast في الـ Peripheral Blood بون مارو أكيد + +188 +00:15:11,660 --> 00:15:15,880 +لازم أشوف فيه Blast أكتر من 20% الأنيميا عادة + +189 +00:15:15,880 --> 00:15:20,070 +بتكون Normocytic Anemia لأنه خلل في التصنيعأشوف + +190 +00:15:20,070 --> 00:15:25,670 +أثرومبوسيتبينيا الـ Neutropenia ممكن تتطور لـ DIC + +191 +00:15:25,670 --> 00:15:30,430 +Bone + +192 +00:15:30,430 --> 00:15:32,910 +marrow in acute leukemia كيف بيكون وضع الـ bone + +193 +00:15:32,910 --> 00:15:36,110 +marrow طبعا الـ bone marrow إذا كان في acute + +194 +00:15:36,110 --> 00:15:39,570 +leukemia لازم نعملهلازم نعمله عشان نعمل diagnosis + +195 +00:15:39,570 --> 00:15:43,650 +ونحدد الـ type للـ leukemia ونعرف الـ prognosis + +196 +00:15:43,650 --> 00:15:46,590 +طبعا الـ acute leukemia are defined by the + +197 +00:15:46,590 --> 00:15:50,010 +presence of more than 20% blast in bone marrow + +198 +00:15:50,010 --> 00:15:53,750 +طبعا قلتلكم أكتر من 20% من خلايا الـ bone marrow + +199 +00:15:53,750 --> 00:16:01,990 +اللي هي الـ nucleated cells هتكون blast cells بدنا + +200 +00:16:01,990 --> 00:16:06,250 +نميز بين الـ AML والـ ALLبالـ Light Microscope + +201 +00:16:06,250 --> 00:16:10,510 +العادى الـ AML فيها أور رود فيها Cytoplasmic + +202 +00:16:10,510 --> 00:16:14,850 +Granules فيها بيروكسيداز Positive طبعا بالـ + +203 +00:16:14,850 --> 00:16:18,810 +Special Stain الـ ALL مافيش فيها أور رود + +204 +00:16:18,810 --> 00:16:23,450 +أوريجرانيال فيها الـ Myloberoxidase Negative والـ + +205 +00:16:23,450 --> 00:16:26,570 +BAS Positive ممكن أميز بشكل صحيح من خلال + +206 +00:16:26,570 --> 00:16:30,110 +Immunophenotyping باستخدام لـ Flow Cytometry ممكن + +207 +00:16:30,110 --> 00:16:31,810 +باستخدام Special Stain + +208 +00:16:35,940 --> 00:16:39,040 +الجزئية التانية اللي بنحكي فيها اللي هي الـ + +209 +00:16:39,040 --> 00:16:42,900 +Chronic Leukemia طبعا Chronic Leukemia بيصير + +210 +00:16:42,900 --> 00:16:46,680 +Clonal expansion of white blood cells are taking + +211 +00:16:46,680 --> 00:16:49,420 +place in the bone marrow بيصير زيادة في الـ white + +212 +00:16:49,420 --> 00:16:53,720 +blood cells لنوع معين من الخلايا طبعا حسب نوع + +213 +00:16:53,720 --> 00:16:58,240 +الخلايا اللي صار فيه الخلل بصنفها لـ Lymphoid و + +214 +00:16:58,240 --> 00:17:01,760 +Myeloid Chronic Lymphocytic Leukemia وChronic + +215 +00:17:01,760 --> 00:17:03,720 +Myelocytic Leukemia + +216 +00:17:36,510 --> 00:17:40,730 +نشوف الـ incidence of chronic leukemia الـ chronic + +217 +00:17:40,730 --> 00:17:45,610 +lymphoid leukemia 90% من حالتها بشوفها في الناس في + +218 +00:17:45,610 --> 00:17:50,370 +سن الخمسينات أو أكتر متوسط العمر عند الـ diagnosis + +219 +00:17:50,370 --> 00:17:55,250 +خمسة و ستين سنة ال incidence of the disease + +220 +00:17:55,250 --> 00:17:59,610 +increase with age يعني مع العمر فرصة حدوث المرض + +221 +00:17:59,610 --> 00:18:03,610 +بتزيد it is almost never seen in children يعني هذه + +222 +00:18:03,610 --> 00:18:07,220 +عادة مابشوفهاش نهائيا عند الأطفالالـ Chronic + +223 +00:18:07,220 --> 00:18:11,020 +Myeloid Leukemia عادةً بتوصف يعني بتكون في منتصف + +224 +00:18:11,020 --> 00:18:16,000 +الأربعينيات من العمر ممكن تشكل 4% من حالات + +225 +00:18:16,000 --> 00:18:20,600 +اللوكيميا عند الأطفال نيجي للـ Lab Diagnosis of + +226 +00:18:20,600 --> 00:18:24,240 +Leukemia أول حاجة الـ Chronic Lymphocytic Leukemia + +227 +00:18:24,240 --> 00:18:28,280 +peripheral blood في الـ peripheral blood بشوف + +228 +00:18:28,280 --> 00:18:32,900 +ارتفاع في الـ lymphocyte lymphocytosis بشوف + +229 +00:18:32,900 --> 00:18:41,950 +thrombocytopeniaانخفاض في الـ Platelets أنيميا الـ + +230 +00:18:41,950 --> 00:18:47,370 +CLL تتميز بوجود خلية اللي هي بسميها Smudge Cell + +231 +00:18:47,370 --> 00:18:50,310 +لأنها هي الـ Cell اللي موجودة في هذه الخلية + +232 +00:18:50,310 --> 00:18:54,790 +Fragile Cell فبتلاقيها بسرعة بيتغير شكلها بتنهرس + +233 +00:18:54,790 --> 00:18:58,950 +خلال الفرد The blood smear could show many + +234 +00:18:58,950 --> 00:19:02,290 +abnormal looking lymphocyte called Smudge Cell + +235 +00:19:02,290 --> 00:19:06,420 +اللي هي مخد هذا الشكلشايفين كيف؟ خلية بتحس إنها بس + +236 +00:19:06,420 --> 00:19:10,360 +نواة مافيش فيها أي معالم تانية كأنه الـ cytoplasm + +237 +00:19:10,360 --> 00:19:15,020 +انهرس خلال الفرد الـ bone marrow عادة بيكون + +238 +00:19:15,020 --> 00:19:18,920 +hypercellular بلاقي فيه زيادة في الـ mature + +239 +00:19:18,920 --> 00:19:21,980 +lymphocyte طيب إيش وضع الـ blast؟ مافيش عندى blast + +240 +00:19:21,980 --> 00:19:26,180 +لأنها chronic الـ blast بيكون عددها قليل جدا يعني + +241 +00:19:26,180 --> 00:19:29,820 +مابيكون فيه عندى blast بشكل ملحوظ زي الـ acute + +242 +00:19:35,270 --> 00:19:38,530 +في عندي أنواع نادرة من الـ Lymphocytic Leukemia + +243 +00:19:38,530 --> 00:19:42,970 +اللي هي الـ Pro-Lymphocytic Leukemia إحنا من ناحية + +244 +00:19:42,970 --> 00:19:47,530 +Morphology قد نميز الـ Lymphocyte إلى 3 مراحل اللي + +245 +00:19:47,530 --> 00:19:51,470 +هي Lymphoblast و Pro-Lymphocyte و Lymphocyte + +246 +00:19:51,470 --> 00:19:55,410 +وقلتلكم إن هذه المراحل كتير في تشابه بينها عشان + +247 +00:19:55,410 --> 00:19:58,250 +هيك أفضل إشي بنميز بينهم من خلال الـ + +248 +00:19:58,250 --> 00:20:02,090 +Immunophenotyping و الـ Cell Markers اللي بتظهر في + +249 +00:20:02,090 --> 00:20:06,110 +كل مرحلة من مراحل الـ Maturation للخليةالـ Pro + +250 +00:20:06,110 --> 00:20:10,370 +-lymphocytic leukemia بلاقي زيادة من الـ Pro + +251 +00:20:10,370 --> 00:20:13,470 +-lymphocyte يعني الـ cancers اللي الموجودة هي Pro + +252 +00:20:13,470 --> 00:20:18,030 +-lymphocyte هي عبارة عن immature form of B or T + +253 +00:20:18,030 --> 00:20:20,990 +-lymphocyte عبارة عن خلية immature يعني مش ال + +254 +00:20:20,990 --> 00:20:24,490 +mature form لأ المرحلة اللي قبلها طبعا ما بلاقي + +255 +00:20:24,490 --> 00:20:27,330 +فيها blast عشان هيك أو بيكون عدد ال blast normal + +256 +00:20:27,330 --> 00:20:29,730 +أو قليل عشان هيك بتعتبر chronic + +257 +00:20:33,920 --> 00:20:38,000 +من الأنواع الأخرى اللي بتعتبر «Rare of lymphoid + +258 +00:20:38,000 --> 00:20:41,980 +leukemia» «Rare type of lymphoid chronic leukemia» + +259 +00:20:41,980 --> 00:20:45,960 +الـ Hairy cell leukemia Hairy cell leukemia عبارة + +260 +00:20:45,960 --> 00:20:50,700 +عن cancer of lymphocyte هذا النوع بـ Progress + +261 +00:20:50,700 --> 00:20:55,720 +slowly يعني يتطور عند الإنسان ببطء الـ Cancer cell + +262 +00:20:55,720 --> 00:21:00,170 +عبارة عن B lymphocyteالـ Cancer Cell عبارة عن Ash + +263 +00:21:00,170 --> 00:21:04,010 +B-Lymphocyte لكن مختلفة عن الخلايا الموجودة في الـ + +264 +00:21:04,010 --> 00:21:08,550 +CLL هنا في اختلاف في الأعراض، اختلاف في الـ + +265 +00:21:08,550 --> 00:21:13,070 +Treatment شغلة تانية، من وين أجى اسمها الـ Hair + +266 +00:21:13,070 --> 00:21:17,830 +Cell إن الخلية هنا تكتسب مجموعة من الـ Projections + +267 +00:21:17,830 --> 00:21:21,850 +أو الذوائد علق من الطلعة من الـCytoplasm على شكل + +268 +00:21:21,850 --> 00:21:26,270 +الـHairs، على شكل شعيرات صغيرةفعشان هيك صار اسمها + +269 +00:21:26,270 --> 00:21:30,190 +Hairy أو أجى اسمها Hairy Cell Leukemia هذه الـ + +270 +00:21:30,190 --> 00:21:32,690 +Hairy Cell Leukemia بتتميز بإنه بيصير + +271 +00:21:32,690 --> 00:21:36,350 +Myelofibrosis بنلاحظ إن الـ bone marrow في هذا + +272 +00:21:36,350 --> 00:21:40,430 +النوع من الأنيميا من اللوكيميا الـ bone marrow كل + +273 +00:21:40,430 --> 00:21:44,810 +ال parameters فيه very low الـRBCs والهمoglobin + +274 +00:21:44,810 --> 00:21:48,250 +الـRBCs، كل الـCBC بتلاقيه واطية الـplatelets + +275 +00:21:48,250 --> 00:21:52,080 +بتلاقيها واطيةالـ YPCs Count برضه بتلاقي واطي + +276 +00:21:52,080 --> 00:21:55,440 +الخلية الـ Predominant اللي هي الـ Hairy Cell إيش + +277 +00:21:55,440 --> 00:21:59,880 +هي الـ Hairy Cell؟ عبارة عن B-Lymphocyte مخدة الـ + +278 +00:21:59,880 --> 00:22:05,840 +Hairy Projection نوع تاني برضه من الـ Chronic + +279 +00:22:05,840 --> 00:22:09,380 +Lymphocytic Leukemia اللي هي Large Granular + +280 +00:22:09,380 --> 00:22:13,740 +Lymphocytic Leukemia طبعاً هذا نوع آخر من الـ + +281 +00:22:13,740 --> 00:22:17,660 +Chronic Leukemia الخلية نفسها هذه هي الـ Natural + +282 +00:22:17,660 --> 00:22:23,830 +Killer Cellاللي هي طبعاً بتقوم بواقع ضائف معينة في + +283 +00:22:23,830 --> 00:22:27,170 +الجسم ممكن هي نفسها يصير فيها cancer خلية كبيرة + +284 +00:22:27,170 --> 00:22:32,810 +فيها بعض الـ granules المميزة لإلها معظم أنواعها + +285 +00:22:32,810 --> 00:22:37,950 +ممكن تكون slow growing يعني بطيقة لكن في عدد قليل + +286 +00:22:37,950 --> 00:22:41,950 +منها ممكن يبقى rapid and aggressive ممكن يكون + +287 +00:22:42,640 --> 00:22:48,040 +الخلايا الشديدة الانقسام وسريعة الانتشار لكن بشكل + +288 +00:22:48,040 --> 00:22:56,020 +عام هي بطيقة التطور وبطيقة التكوين Chronic + +289 +00:22:56,020 --> 00:23:01,120 +Myelocytic Leukemia بالنسبة لهذا النوع من + +290 +00:23:01,120 --> 00:23:06,580 +الليوكيميا هنلاقي فيه expansion للـgranulocytic + +291 +00:23:06,580 --> 00:23:10,520 +precursors يعني هتلاقي كل ال immature forms تعتلي + +292 +00:23:10,520 --> 00:23:14,720 +granulocyte موجودةwithout regulation، يعني هتلاقي + +293 +00:23:14,720 --> 00:23:18,500 +عندك Bromelocyte، هتلاقي Metamelocyte، في الـ + +294 +00:23:18,500 --> 00:23:22,720 +Peripheral Blood وفي الـ Bone marrow، هتلاقي بعدها + +295 +00:23:22,720 --> 00:23:26,760 +Metamelocyte، هتلاقي Band Cells، طبعا أنا مابحكيش + +296 +00:23:26,760 --> 00:23:29,800 +بس Neutrophil، هتلاقي كله، هتلاقي Xenophil، هتلاقي + +297 +00:23:29,800 --> 00:23:34,870 +Bezophil، هتلاقي Neutrophilهتلاقي mature farms + +298 +00:23:34,870 --> 00:23:37,430 +يعني هتلاقي كل الـ precursors بتاعة الـ + +299 +00:23:37,430 --> 00:23:39,530 +granulocyte موجودة في الـ peripheral blood صارت + +300 +00:23:39,530 --> 00:23:43,130 +عندك بعدد كبير وحتى هتلاقي عدد الـ YPCs عندك عالي + +301 +00:23:43,130 --> 00:23:48,990 +كثير البرضه الـ megakaryocytobiosis هيصير فيه + +302 +00:23:48,990 --> 00:23:53,050 +expansion يعني هيزيد و هيزيد العدد اللي بتتكون و + +303 +00:23:53,050 --> 00:23:55,810 +غالباً بتلاقي الـ platelets في هذه الحالات عالية + +304 +00:23:55,810 --> 00:24:00,730 +erythropoiesis هيصير فيه defect هيصير فيه نقص في + +305 +00:24:00,730 --> 00:24:04,100 +عدد ال RBCsfunction of the neutrophil والـ + +306 +00:24:04,100 --> 00:24:07,200 +platelets عادة يعني بتكون تقريبا normally يعني ما + +307 +00:24:07,200 --> 00:24:11,140 +بتتأثر ال function لإنها في المعظم حالات الـCML + +308 +00:24:11,140 --> 00:24:14,240 +هنلاقي عندهم الـ Philadelphia chromosome + +309 +00:24:14,240 --> 00:24:18,480 +Philadelphia chromosome هذا عبارة عن أو جاي من + +310 +00:24:18,480 --> 00:24:24,540 +translocation لقطع من كرمزوم 9 إلى كرمزوم 22طبعاً + +311 +00:24:24,540 --> 00:24:28,320 +في قطعة من كروموزوم 22 هتروحها كروموزوم 9 هذا مش + +312 +00:24:28,320 --> 00:24:32,040 +راح يعمل إشي بس اللي هيشتغل اللي هو التركيبة + +313 +00:24:32,040 --> 00:24:34,940 +الجديدة لكروموزوم 22 اللي بيسمى بالفلادلفيا + +314 +00:24:34,940 --> 00:24:39,880 +كروموزوم ناتج عن انتقال قطعة الـ ABL من كروموزوم 9 + +315 +00:24:39,880 --> 00:24:44,980 +إلى كروموزوم 22 هذه التركيبة اللي بيسموها PCR-ABL + +316 +00:24:44,980 --> 00:24:51,580 +هذه عادةً وجدوا إنه لها Tyrosine Kinase Activity + +317 +00:24:52,020 --> 00:24:55,580 +فهي بتحفز انقسام الخلايا وتكثرها عشان هيك بيزيد + +318 +00:24:55,580 --> 00:25:00,980 +عدد الخلايا و بيصير uncontrolled معظم المرضى اللي + +319 +00:25:00,980 --> 00:25:03,660 +عندهم CML بيلاقوا عندهم الـ Philadelphia + +320 +00:25:03,660 --> 00:25:06,960 +chromosome فبالتالي سهل إنهم يعالجوهم كيف + +321 +00:25:06,960 --> 00:25:11,420 +بيعالجوهم؟ بيعالجوهم عن طريق Anti-Tyrosine Kinase + +322 +00:25:11,420 --> 00:25:15,020 +بيعطوهم مضاد للـTyrosine Kinase فبوقف ال activity + +323 +00:25:15,020 --> 00:25:18,820 +لإلهالآن الناس اللي ما عندهم مشهاد الـ mutation + +324 +00:25:18,820 --> 00:25:22,880 +بيكون وضعهم أصعب شوية يعني مرضى الـCML اللي عندهم + +325 +00:25:22,880 --> 00:25:25,940 +Philadelphia chromosome بيلاقوا علاج أفضل من اللي + +326 +00:25:25,940 --> 00:25:28,900 +ما عندهم Philadelphia chromosome مش كل مرضى الـCML + +327 +00:25:28,900 --> 00:25:32,980 +عندهم الـPhiladelphia chromosome positive طيب، + +328 +00:25:32,980 --> 00:25:40,000 +ننتقل إلى ال phases of CML الـphase الأولى اللي هي + +329 +00:25:40,000 --> 00:25:45,260 +الـchronic phase بنلاقي الـblast cellsعددها أقل من + +330 +00:25:45,260 --> 00:25:48,280 +10% في الـ Peripheral blood مانلاقيش Blast كتير + +331 +00:25:48,280 --> 00:25:54,300 +وهذه المرحلة ممكن تظل فترة طويلة لكن ممكن تقلب + +332 +00:25:54,300 --> 00:25:59,540 +لمراحل اللي بعدها المرحلة اللي بعدها ممكن تيجي + +333 +00:25:59,540 --> 00:26:02,500 +اللي هي الـ Accelerated phase بلاقي الـ Blast + +334 +00:26:02,500 --> 00:26:06,780 +Cells بلش هتتزيد ممكن توصل لـ 30% في الـ + +335 +00:26:06,780 --> 00:26:10,020 +Peripheral blood أو في البولمروالـ platelets ممكن + +336 +00:26:10,020 --> 00:26:13,640 +تكون very low أقل من 100 ألف أو أكتر من مليون أو + +337 +00:26:13,640 --> 00:26:19,240 +عالية كتير في عندي أشياء تانية ممكن ألاقيها لو + +338 +00:26:19,240 --> 00:26:23,820 +أجيت عملت الـ cytogenetic studies حلائق الفلادلفيا + +339 +00:26:23,820 --> 00:26:30,480 +كروموزام حلائق splenomegaly عند هدول الناس هذه الـ + +340 +00:26:30,480 --> 00:26:33,820 +accelerated phase هذه الـ accelerated phase ممكن + +341 +00:26:33,820 --> 00:26:40,410 +تتطور للـ blast crisis هنا حلائقأكتر من 30% بلاست + +342 +00:26:40,410 --> 00:26:44,650 +في الـ Peripheral blood في البون مرو البلاست لو + +343 +00:26:44,650 --> 00:26:48,570 +أجيت عملت بون مرو بيوبسي هلاقي كميات كبيرة من + +344 +00:26:48,570 --> 00:26:52,650 +البلاست في البون مرو بيوبسي بالاضافة لإنه ممكن + +345 +00:26:52,650 --> 00:26:56,270 +تعمل Extra Medullary Infiltration اللي بلاست سلس + +346 +00:26:56,270 --> 00:27:00,610 +هذه تنتقل أماكن أخرى خارج البون مرو تعمل + +347 +00:27:00,610 --> 00:27:04,710 +Infiltration نيجي + +348 +00:27:04,710 --> 00:27:11,090 +إيش بنشوف عند المريض هذا؟أول حاجة الـ CPC الـ CPC + +349 +00:27:11,090 --> 00:27:17,430 +عادة الـ White PCs عندهم عالية عالية كتير يعني + +350 +00:27:17,430 --> 00:27:23,950 +غالبا بتكون أكتر من 50 ألف ممكن تزيد عن 500 ألف + +351 +00:27:23,950 --> 00:27:28,530 +يعني أحيانا بنعمل dilution أكتر عالي للعين عشان + +352 +00:27:28,530 --> 00:27:31,930 +يقدر الجهاز يعدها تبقى طبقة الـ White PCs عندهم + +353 +00:27:31,930 --> 00:27:37,540 +عالية جدا مرضى الـ CML هذه شغلةهيصير عندهم أنيميا + +354 +00:27:37,540 --> 00:27:41,880 +لأنه فيه defective erythropoiesis أشنع الأنيميا + +355 +00:27:41,880 --> 00:27:46,240 +هذه خلل في التصنيع فهتكون normocytic normochromic + +356 +00:27:46,240 --> 00:27:49,240 +يعني مش هيكون فيها إيبوكراميا أو لأ هتكون + +357 +00:27:49,240 --> 00:27:53,000 +normocytic normochromic أنيميا بالنسبة + +358 +00:27:53,000 --> 00:27:57,900 +للـplatelets الـplatelets variable يعني ممكن تبقى + +359 +00:27:57,900 --> 00:28:03,460 +high ممكن تبقى normal ممكن تبقى low لو جينا + +360 +00:28:03,460 --> 00:28:06,650 +للـperipheral blood filmفي الـ Prefrontal Blast + +361 +00:28:06,650 --> 00:28:12,070 +Film هنلاقي Circulating Myeloid Precursors بكمية + +362 +00:28:12,070 --> 00:28:16,350 +كبيرة بالاضافة لوجود Bezophil يعني لو جينا هنا + +363 +00:28:16,350 --> 00:28:20,490 +هنلاقي كل الـ Precursors بتاعة الـ Granulocyte + +364 +00:28:20,490 --> 00:28:26,030 +موجودة هنلاقي برو .. طبعا Blast لأ مش هنلاقي Blast + +365 +00:28:26,030 --> 00:28:29,950 +هنلاقي Bromelocyte مثلاً هنلاقي Myeloid Cells + +366 +00:28:29,950 --> 00:28:34,630 +هنلاقي Metamyelocyte هنلاقي Bandطبعاً هدول إذا + +367 +00:28:34,630 --> 00:28:38,110 +كنتوا فاكرين عبارة عن الـNucleated RBCs اللي هنا + +368 +00:28:38,110 --> 00:28:42,890 +ممكن ألاقي بيزوفيليا ممكن ألاقي Band Cells ممكن + +369 +00:28:42,890 --> 00:28:46,550 +ألاقي Mature Cells هذه Metamyelocyte هذه مثلا + +370 +00:28:46,550 --> 00:28:52,970 +Myelocyte وها كذا، يعني ممكن أشوف عندي كل الـ + +371 +00:28:52,970 --> 00:28:58,750 +Maturation Stages بتاعة الـMyeloid Precursors في + +372 +00:28:58,750 --> 00:29:03,470 +الـBlood Film لهم، وهذا الفيلمبتذكر أنا لما درستكم + +373 +00:29:03,470 --> 00:29:07,230 +الـ Hematology جبتلكم فيلم مطابق لهذا اللي شبكتلكم + +374 +00:29:07,230 --> 00:29:10,210 +إياه على الكاميرا ومن الكاميرا ميكروسكوب وكاميرا + +375 +00:29:10,210 --> 00:29:14,750 +ومن الكاميرا على الصبورة وصرت أعرضلكم بعض الخلايا + +376 +00:29:14,750 --> 00:29:20,110 +كان فيلم «CML» يعني كانت حالة اتعلمنا من خلالها كل + +377 +00:29:20,110 --> 00:29:23,230 +الـ Maturation Stages على داك الفيلم إذا كنتوا + +378 +00:29:23,230 --> 00:29:28,770 +فاكرين تمام؟ هيك يا بنات بنكون إحنا مرينا على + +379 +00:29:28,770 --> 00:29:32,830 +اللوكيميا بأنواعهامرّينا على الـ Acute Leukemia + +380 +00:29:32,830 --> 00:29:37,870 +Acute Myeloid Acute Lymphocytic Leukemia وأخدنا + +381 +00:29:37,870 --> 00:29:42,990 +تقسيماتها وتصنيفاتها تقسيماتها إما حسب الـ + +382 +00:29:42,990 --> 00:29:47,630 +Morphology أو حسب الـ Immunophenotyping أو حسب الـ + +383 +00:29:47,630 --> 00:29:52,390 +Cytogenetic Studies الخاصة بالخلايا وبعد هيك + +384 +00:29:52,390 --> 00:29:56,670 +مرّينا على الـ Chronic Leukemia برضه بتقسيماتها + +385 +00:29:56,670 --> 00:30:02,570 +وبالأشياء اللي يعني ممكن نشوفها فيهاقلنا إنها قد + +386 +00:30:02,570 --> 00:30:08,450 +تكون lymphoid أو myeloid طبعا الـ lymphoid أخدنا + +387 +00:30:08,450 --> 00:30:11,890 +النوع الأساسي chronic lymphocytic leukemia وفي عند + +388 +00:30:11,890 --> 00:30:16,430 +بعض الأنواع أقل شيوعا زي الـ prolymphocytic + +389 +00:30:16,430 --> 00:30:22,190 +leukemia حكينا عنها و ال large cell leukemia اللي + +390 +00:30:22,190 --> 00:30:25,530 +فيها natural killer cells حكينا عن الhair cell + +391 +00:30:25,530 --> 00:30:32,180 +leukemia وقلنا إنه لها شكل مميز للخلايابعد هيك + +392 +00:30:32,180 --> 00:30:37,640 +انتقلنا للـCML وأخدنا الـChronic Myeloid Leukemia + +393 +00:30:37,640 --> 00:30:41,820 +إيش صفاتها وإيش خصائصها هيك بنقدر نقول إن إحنا + +394 +00:30:41,820 --> 00:30:45,060 +غطينا اللوكيميا وإن شاء الله في المراحل القادمة + +395 +00:30:45,060 --> 00:30:49,920 +راح نحاول نتعرف على إنه أنا بدي أكون بارعة في + +396 +00:30:49,920 --> 00:30:54,020 +الـDiagnosis لحالات اللوكيميا كيف أنا أحدد + +397 +00:30:54,020 --> 00:30:58,080 +الـDiagnosis كيف 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"word": " Leukemia", "probability": 0.87353515625}, {"start": 236.86, "end": 238.06, "word": " Translocation", "probability": 0.9493815104166666}, {"start": 238.06, "end": 239.2, "word": " 1517", "probability": 0.9521484375}, {"start": 239.2, "end": 240.26, "word": " الـ", "probability": 0.906494140625}, {"start": 240.26, "end": 241.02, "word": " M7", "probability": 0.980712890625}, {"start": 241.02, "end": 241.92, "word": " بيصير", "probability": 0.984130859375}, {"start": 241.92, "end": 243.12, "word": " Deletion", "probability": 0.7974446614583334}, {"start": 243.12, "end": 244.1, "word": " فيه", "probability": 0.82568359375}, {"start": 244.1, "end": 244.54, "word": " كرمزوم", "probability": 0.8068359375}, {"start": 244.54, "end": 245.1, "word": " 11", "probability": 0.96435546875}, {"start": 245.1, "end": 245.72, "word": " الـ", "probability": 0.861572265625}, {"start": 245.72, "end": 246.3, "word": " M4", "probability": 0.99072265625}, {"start": 246.3, "end": 247.38, "word": " Inversion", "probability": 0.772216796875}, {"start": 247.38, "end": 247.98, "word": " 16", "probability": 0.98681640625}, {"start": 247.98, "end": 248.98, "word": " Translocation", "probability": 0.7736002604166666}, {"start": 248.98, "end": 249.98, "word": " 1616", "probability": 0.955078125}, {"start": 249.98, "end": 250.64, "word": " M6", "probability": 0.909912109375}], "temperature": 1.0}, {"id": 10, "seek": 27102, "start": 251.13, "end": 271.03, "text": "Translocation 8 إلى 16 أكتر واحد شيوعاً وبدي ياكم تعرفوا اللي هو بيصير في الـAML عادة الـAML شهيرة بالـ15-17 Translocation اللي هي الـM3 يعني أقصد الـAML M3", "tokens": [33339, 5842, 399, 1649, 30731, 3165, 5551, 4117, 2655, 2288, 36764, 24401, 13412, 1829, 45367, 995, 14111, 4032, 44510, 1829, 35186, 24793, 37279, 28480, 14407, 13672, 1829, 31439, 4724, 1829, 9381, 13546, 8978, 2423, 39184, 2865, 43, 6225, 18513, 3660, 2423, 39184, 2865, 43, 13412, 3224, 48923, 20666, 39184, 5211, 12, 7773, 6531, 5842, 399, 13672, 1829, 39896, 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"end": 267.13, "word": " اللي", "probability": 0.961181640625}, {"start": 267.13, "end": 267.33, "word": " هي", "probability": 0.814453125}, {"start": 267.33, "end": 268.83, "word": " الـM3", "probability": 0.8616943359375}, {"start": 268.83, "end": 269.09, "word": " يعني", "probability": 0.945556640625}, {"start": 269.09, "end": 269.91, "word": " أقصد", "probability": 0.9554443359375}, {"start": 269.91, "end": 270.45, "word": " الـAML", "probability": 0.9488525390625}, {"start": 270.45, "end": 271.03, "word": " M3", "probability": 0.952392578125}], "temperature": 1.0}, {"id": 11, "seek": 29247, "start": 277.39, "end": 292.47, "text": "طيب هنا برضه يعني بعض أنواع اللوكيميا والممكن أش اللي translocations اللي بتصير فيها لو أجينا نشوف يعني كل نوع اللوكيميا موجودة حكيلك أش ممكن يصير فيها inversion أو translocation", "tokens": [9566, 1829, 3555, 34105, 4724, 43042, 3224, 37495, 22653, 45030, 11242, 14739, 14407, 3615, 13672, 2407, 4117, 32640, 25528, 4032, 45340, 43020, 5551, 8592, 13672, 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"start": 384.39, "end": 411.97, "text": "طيب، الآن إيش علاقة الكرموزومة الـ Abnormalities بالـ Prognosis في حالات الـ ALL؟ هلقيت بقولّك لو كان الـ Karyotyping Normal وفي عندي Hyperploidي يعني زيادة في عدد الكرموزومات الـ Prognosis بيكون أفضل لكن الـ Pore Prognosis لو كان Translocation 814 أو 411", "tokens": [9566, 1829, 3555, 12399, 6024, 48506, 11933, 1829, 8592, 11203, 995, 28671, 33251, 2288, 2304, 2407, 11622, 20498, 3660, 2423, 39184, 2847, 23157, 1088, 20666, 39184, 1705, 4568, 8211, 8978, 11331, 6027, 9307, 2423, 39184, 14824, 22807, 8032, 1211, 4587, 36081, 4724, 39648, 11703, 4117, 45164, 25961, 2423, 39184, 591, 822, 6737, 3381, 21277, 4032, 41185, 18871, 16254, 29592, 564, 17079, 1829, 37495, 22653, 30767, 1829, 18513, 3660, 8978, 6225, 3215, 3215, 33251, 2288, 2304, 2407, 11622, 20498, 9307, 2423, 39184, 1705, 4568, 8211, 4724, 1829, 30544, 5551, 5172, 11242, 1211, 44381, 2423, 39184, 430, 418, 1705, 4568, 8211, 45164, 25961, 6531, 5842, 399, 1649, 7271, 34051, 1017, 5348], 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"word": " حالات", "probability": 0.9168294270833334}, {"start": 391.51, "end": 391.71, "word": " الـ", "probability": 0.949951171875}, {"start": 391.71, "end": 392.89, "word": " ALL؟", "probability": 0.689208984375}, {"start": 392.89, "end": 393.13, "word": " هلقيت", "probability": 0.63092041015625}, {"start": 393.13, "end": 393.75, "word": " بقولّك", "probability": 0.82904052734375}, {"start": 393.75, "end": 394.97, "word": " لو", "probability": 0.7587890625}, {"start": 394.97, "end": 395.43, "word": " كان", "probability": 0.9306640625}, {"start": 395.43, "end": 396.25, "word": " الـ", "probability": 0.91064453125}, {"start": 396.25, "end": 397.59, "word": " Karyotyping", "probability": 0.81787109375}, {"start": 397.59, "end": 399.29, "word": " Normal", "probability": 0.56884765625}, {"start": 399.29, "end": 399.75, "word": " وفي", "probability": 0.875}, {"start": 399.75, "end": 400.07, "word": " عندي", "probability": 0.72705078125}, {"start": 400.07, "end": 401.07, "word": " Hyperploidي", "probability": 0.7249755859375}, {"start": 401.07, "end": 401.23, "word": " يعني", "probability": 0.90234375}, {"start": 401.23, "end": 401.61, "word": " زيادة", "probability": 0.9876708984375}, {"start": 401.61, "end": 401.73, "word": " في", "probability": 0.978515625}, {"start": 401.73, "end": 401.99, "word": " عدد", "probability": 0.9913736979166666}, {"start": 401.99, "end": 402.91, "word": " الكرموزومات", "probability": 0.9524274553571429}, {"start": 402.91, "end": 403.53, "word": " الـ", "probability": 0.744384765625}, {"start": 403.53, "end": 403.95, "word": " Prognosis", "probability": 0.95263671875}, {"start": 403.95, "end": 404.31, "word": " بيكون", "probability": 0.9739583333333334}, {"start": 404.31, "end": 405.05, "word": " أفضل", "probability": 0.996826171875}, {"start": 405.05, "end": 405.99, "word": " لكن", "probability": 0.9375}, {"start": 405.99, "end": 407.03, "word": " الـ", "probability": 0.8310546875}, {"start": 407.03, "end": 407.21, "word": " Pore", "probability": 0.4207763671875}, {"start": 407.21, "end": 407.89, "word": " Prognosis", "probability": 0.8972981770833334}, {"start": 407.89, "end": 408.15, "word": " لو", "probability": 0.9794921875}, {"start": 408.15, "end": 408.41, "word": " كان", "probability": 0.998046875}, {"start": 408.41, "end": 409.33, "word": " Translocation", "probability": 0.726318359375}, {"start": 409.33, "end": 410.23, "word": " 814", "probability": 0.3125}, {"start": 410.23, "end": 411.01, "word": " أو", "probability": 0.94287109375}, {"start": 411.01, "end": 411.97, "word": " 411", "probability": 0.930908203125}], "temperature": 1.0}, {"id": 13, "seek": 44062, "start": 413.18, "end": 440.62, "text": "very poor prognosis سيئ جداً translocation اللي هو 922 هذه بتعتبر very poor prognosis بعض الكرمزومة الـ abnormalities في الـ AML و علاقتها بالـ prognosis الآن الـ good prognosis الـ good prognosis بيحصل لو كان في عندي translocation 8 إلى 21", "tokens": [448, 4716, 447, 4568, 8211, 8608, 1829, 19986, 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1860.94, "end": 1861.52, "word": "بيعطيكم", "probability": 0.868359375}, {"start": 1861.52, "end": 1861.8, "word": " ألف", "probability": 0.903076171875}, {"start": 1861.8, "end": 1862.22, "word": " عافية", "probability": 0.9807942708333334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1870.41375, "duration_after_vad": 1678.601249999996} \ No newline at end of file diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/U5ZlKzo79yw_raw.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/U5ZlKzo79yw_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..bc5690a95061de9b4da22ed55ec43e49b42bdd65 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/U5ZlKzo79yw_raw.srt @@ -0,0 +1,1592 @@ +1 +00:00:15,420 --> 00:00:18,420 +نجي للجزئية الرابعة في الـDiagnosis المهمة في + +2 +00:00:18,420 --> 00:00:20,140 +الـDiagnosis اللي هي جزئية + +3 +00:00:20,140 --> 00:00:24,120 +الـCytogeneticsCytogenetic studies ممكن الآن + +4 +00:00:24,120 --> 00:00:28,840 +تستخدم في الـDiagnosis لحالات من حالات + +5 +00:00:28,840 --> 00:00:32,260 +الـHematologic Malignancies وبرضه للتنبؤ + +6 +00:00:32,260 --> 00:00:35,700 +بالـPrognosis يعني ممكن بناء على الـAbnormality + +7 +00:00:35,700 --> 00:00:40,240 +اللي صايرة نتوقع إيش الـPrognosis في كتير أنواع من + +8 +00:00:40,240 --> 00:00:44,410 +أنواع اللوكيميا والانفامةتتميز بوجود Specific + +9 +00:00:44,410 --> 00:00:48,230 +Chromosomal Abnormalities يعني فيه Abnormality إذا + +10 +00:00:48,230 --> 00:00:51,430 +لاقناها بنتوقع هذا النوع من اللوكيميا أو يمكن يكون + +11 +00:00:51,430 --> 00:00:54,790 +الـDiagnosis إنه عندي هذا النوع من اللوكيميا + +12 +00:00:54,790 --> 00:00:58,910 +Including Specific Translocation and Anibloidy + +13 +00:00:58,910 --> 00:01:03,030 +ممكن يكون على شكل Translocation …Chromosomal + +14 +00:01:03,030 --> 00:01:08,890 +Translocation أو على شكل Anibloidy اللي هو زيادة + +15 +00:01:08,890 --> 00:01:12,720 +أو تغير أكتر أو نقصان في عدد الكروموزوماتThe + +16 +00:01:12,720 --> 00:01:15,820 +specific type of malignancy can be identified + +17 +00:01:15,820 --> 00:01:19,620 +based on the specific abnormality or translocation + +18 +00:01:19,620 --> 00:01:25,080 +يعني احنا ممكن نتنبأ بنوع الـ Malignancy أو نشخصها + +19 +00:01:25,080 --> 00:01:28,260 +بناء على الـ abnormality أو الـ translocation اللي + +20 +00:01:28,260 --> 00:01:31,890 +صاريعني عندنا مثلًا دائمًا لما بلاقي الـ + +21 +00:01:31,890 --> 00:01:36,090 +Philadelphia chromosome بتوقع إنه في حالة CML أو + +22 +00:01:36,090 --> 00:01:39,670 +ممكن تتطور حالة CML يعني التنتين هدول مثلًا + +23 +00:01:39,670 --> 00:01:43,170 +مرتبطين ببعض فبالتالي بناءً على الـ Translocation + +24 +00:01:43,170 --> 00:01:47,270 +أنا ممكن أعرف أو أشخص نوع معين من أنواع الـ + +25 +00:01:47,270 --> 00:01:52,270 +Malignancy في خلايا الدمThis may be identified by + +26 +00:01:52,270 --> 00:01:55,790 +ممكن هذه الـ Abnormalities أحنا نعملها عن طريق الـ + +27 +00:01:55,790 --> 00:02:00,650 +Karyotyping عشان نشوف أعداد الكرومزومات أو فحوصات + +28 +00:02:00,650 --> 00:02:06,850 +يعني الـ DNA المختلفة طبعا يعني في فحوصات متعددة + +29 +00:02:06,850 --> 00:02:10,370 +حسب نوع الخلل اللي أنا بدي أكشف عنه ممكن أختار + +30 +00:02:10,370 --> 00:02:14,780 +الفحص المناسبعادة ملاحظة مهمة إذا كان الـ + +31 +00:02:14,780 --> 00:02:18,460 +Karyotyping normal بنتوقع إن الحالة يكون الـ + +32 +00:02:18,460 --> 00:02:21,640 +Habitat Prognosis يعني كل ما كان الـ Karyotyping + +33 +00:02:21,640 --> 00:02:24,720 +فيه defect أو فيه مشكلة فهذا بالتالي على الـ + +34 +00:02:24,720 --> 00:02:27,940 +Translocation between two chromosomes اللي هو + +35 +00:02:27,940 --> 00:02:32,400 +كرمزوم 7 و كرمزوم 8 صار تبادل لقطعتين في الـ long + +36 +00:02:32,400 --> 00:02:37,240 +arm فنشأ عندي كرمزومات حصل فيها Translocation يعني + +37 +00:02:37,240 --> 00:02:42,680 +كل واحد ماخد رزق من الكرمزوم التانيطبعاً هذا الـ + +38 +00:02:42,680 --> 00:02:45,160 +Karyotyping بيعطينا صورة الـ Karyotyping كيف + +39 +00:02:45,160 --> 00:02:48,540 +الكرمزومات لما احنا بنفرزها و بنبلش نتعرف عليها و + +40 +00:02:48,540 --> 00:02:55,600 +نعيدها طيب نيجي لبعض أنواع الـ Abnormalities الـ + +41 +00:02:55,600 --> 00:02:59,300 +Common في أنواع معينة من اللوكينيا يعني على سبيل + +42 +00:02:59,300 --> 00:03:07,520 +المثال الـ ALL شائع فيها Translocation 9.22 لـ Pre + +43 +00:03:07,520 --> 00:03:13,620 +-ALL Translocation 1.19عادةً هذه بتكون موجودة في + +44 +00:03:13,620 --> 00:03:18,840 +الـ L1 هذه في L1 و L2 الـ PALL ممكن يصير فيها + +45 +00:03:18,840 --> 00:03:25,060 +Translocation ما بين 8 و 14، 8 و 22، 2 و 8 يعني + +46 +00:03:25,060 --> 00:03:28,240 +تمانية هنا مشترك فيهم ممكن يعمل Translocation يصير + +47 +00:03:28,240 --> 00:03:32,940 +Translocation بينه وبين 2 أو 22 أو 14 في الـ + +48 +00:03:32,940 --> 00:03:37,460 +Parietal lymphoma في الـ L3 في الـ TALL ممكن يصير + +49 +00:03:37,460 --> 00:03:43,660 +Translocation 11 و 14 في L1 و L2الـ AML الـ AML + +50 +00:03:43,660 --> 00:03:47,860 +بيصير فيها عادة حسب يعني عندنا مثلا في الـ M2 ممكن + +51 +00:03:47,860 --> 00:03:52,800 +يصي ألاقي Translocation 821 في الـ M3 وهذا شائع + +52 +00:03:52,800 --> 00:03:56,860 +جدا اللي هو Acute Bromelocyte Leukemia + +53 +00:03:56,860 --> 00:04:04,100 +Translocation 1517 الـ M7 بيصير Deletion فيه + +54 +00:04:04,100 --> 00:04:09,980 +كرمزوم 11 الـ M4 Inversion 16 Translocation 1616 + +55 +00:04:09,980 --> 00:04:14,910 +M6Translocation 8 إلى 16 أكتر واحد شيوعاً وبدي + +56 +00:04:14,910 --> 00:04:19,170 +ياكم تعرفوا اللي هو بيصير في الـAML عادة الـAML + +57 +00:04:19,170 --> 00:04:27,130 +شهيرة بالـ15-17 Translocation اللي + +58 +00:04:27,130 --> 00:04:31,030 +هي الـM3 يعني أقصد الـAML M3 + +59 +00:04:37,390 --> 00:04:42,190 +طيب هنا برضه يعني بعض أنواع اللوكيميا والممكن أش + +60 +00:04:42,190 --> 00:04:47,110 +اللي translocations اللي بتصير فيها لو أجينا نشوف + +61 +00:04:47,110 --> 00:04:50,590 +يعني كل نوع اللوكيميا موجودة حكيلك أش ممكن يصير + +62 +00:04:50,590 --> 00:04:52,470 +فيها inversion أو translocation + +63 +00:06:24,390 --> 00:06:28,690 +طيب، الآن إيش علاقة الكرموزومة الـ Abnormalities + +64 +00:06:28,690 --> 00:06:34,970 +بالـ Prognosis في حالات الـ ALL؟ هلقيت بقولّك لو + +65 +00:06:34,970 --> 00:06:41,070 +كان الـ Karyotyping Normal وفي عندي Hyperploidي + +66 +00:06:41,070 --> 00:06:44,310 +يعني زيادة في عدد الكرموزومات الـ Prognosis بيكون + +67 +00:06:44,310 --> 00:06:49,330 +أفضل لكن الـ Pore Prognosis لو كان Translocation + +68 +00:06:49,330 --> 00:06:56,700 +814 أو 411very poor prognosis سيئ جداً + +69 +00:06:56,700 --> 00:07:02,300 +translocation اللي هو 922 هذه بتعتبر very poor + +70 +00:07:02,300 --> 00:07:07,480 +prognosis بعض + +71 +00:07:07,480 --> 00:07:11,000 +الكرمزومة الـ abnormalities في الـ AML و علاقتها + +72 +00:07:11,000 --> 00:07:16,220 +بالـ prognosis الآن الـ good prognosis الـ good + +73 +00:07:16,220 --> 00:07:20,080 +prognosis بيحصل لو كان في عندي translocation 8 إلى + +74 +00:07:20,080 --> 00:07:26,130 +21أو 15 إلى 17 أو صار Inversion 16 Intermediate زي + +75 +00:07:26,130 --> 00:07:32,430 +Anormal Karyotyping أو زيادة في بعض الكرمزومات زي + +76 +00:07:32,430 --> 00:07:35,830 +كرمزوم 8، 21، 22 أو Deletion في الـLong Arm + +77 +00:07:35,830 --> 00:07:39,870 +للكرمزوم 7 أو Deletion في الـLong Arm للكرمزوم 9 + +78 +00:07:39,870 --> 00:07:45,930 +بعد Prognosis إذا كان فيه نقص في كرمزوم 5 أو 7 إذا + +79 +00:07:45,930 --> 00:07:49,150 +كان فيه Deletion في الـLong Arm لكرمزوم 5 أو + +80 +00:07:49,150 --> 00:07:53,950 +AbnormalLong arm لـChromosome 3 Complex + +81 +00:07:53,950 --> 00:07:58,030 +stereotyping يعني إذا كان في عندى أكتر من تلاتة + +82 +00:07:58,030 --> 00:08:01,030 +إلى خمسة abnormality بيبقى ال diagnosis هنا very + +83 +00:08:01,030 --> 00:08:05,630 +bad طبعا هدول مش للحفظ دعوني ال ALL أنا بدي أقول + +84 +00:08:05,630 --> 00:08:10,050 +تحفظوهم بس هدول لأ الآن ال path of physiology of + +85 +00:08:10,050 --> 00:08:15,170 +acute leukemia إيش بتصير؟ طبعا بتصير ال mortality + +86 +00:08:15,170 --> 00:08:20,010 +و ال morbidity من تلت أشياء رئيسية أول حاجةالـ + +87 +00:08:20,010 --> 00:08:25,010 +hemobiosis بشكل عام صار فيه خلل فبالتالي مافيش + +88 +00:08:25,010 --> 00:08:29,430 +normal blood cell number or function يعني بتفقد + +89 +00:08:29,430 --> 00:08:31,910 +وظيفتها و بيبقى اللي فيه عدد طبيعي يعني white + +90 +00:08:31,910 --> 00:08:35,170 +pieces مش هتكون موجودة الـ normal بشكل كافي + +91 +00:08:35,170 --> 00:08:38,630 +فبالتالي هتأخذه الميكروفات الجسم البلاتلتز هيصير + +92 +00:08:38,630 --> 00:08:41,710 +فيها deficiency فهيصير bleeding RBCs برضه هيكون + +93 +00:08:41,710 --> 00:08:46,130 +فيها نخص فهيصير anemiaالشغلة التانية أن هذه + +94 +00:08:46,130 --> 00:08:50,710 +الخلايا كالـ Malignant هتخزوا الـ vital organs في + +95 +00:08:50,710 --> 00:08:54,510 +الجسم وتؤثر على الـ function بتاعتها كمان شغلة + +96 +00:08:54,510 --> 00:08:57,470 +ممكن يصير systemic disturbances shown by metabolic + +97 +00:08:57,470 --> 00:09:00,970 +imbalance هيصير خلل في الميتابوليزم نتيجة وجود + +98 +00:09:00,970 --> 00:09:05,270 +الخلايا هذه وبعض المكونات اللي ممكن الخلايا هذه + +99 +00:09:05,270 --> 00:09:09,750 +تفرزها أو تكونها هتأثر علىبداية Deficiency of + +100 +00:09:09,750 --> 00:09:12,690 +normal blood cell number or function زي ما حكينا + +101 +00:09:12,690 --> 00:09:16,570 +هيصير خلال في الـ White BCs يؤدي لإنفكشن في الـ + +102 +00:09:16,570 --> 00:09:18,970 +Blatulate يؤدي لهيموراج في الـRBCs هيؤدي لأنمي + +103 +00:09:18,970 --> 00:09:23,370 +Infiltration of tissue or organs الشغل التاني أن + +104 +00:09:23,370 --> 00:09:27,570 +الخلايا هذه تغذو بعض ال organs فممكن تعمل بالتالي + +105 +00:09:27,570 --> 00:09:30,370 +enlargement للـ liver للـspleen للـ lymph nodes + +106 +00:09:30,370 --> 00:09:35,500 +ممكن تعمل gum hypertrophyممكن تعمل ألم شديد في + +107 +00:09:35,500 --> 00:09:38,720 +العظام أخر أرغن ممكن يوصل لها زي الـ Central + +108 +00:09:38,720 --> 00:09:43,320 +Nervous System والسكن والتستس وأي أرغن ممكن تصيح + +109 +00:09:43,320 --> 00:09:48,380 +صورة على الجم Hypertrophy في + +110 +00:09:48,380 --> 00:09:52,380 +الـ AML أنفار تكون فيها Xenophilic cells وبرضه الـ + +111 +00:09:52,380 --> 00:09:55,420 +Monocyte زي ما انتوا عارفين ممكن تعمل Infiltration + +112 +00:09:55,420 --> 00:09:58,420 +من صفاتها الـ Monocytechelochemistry أنها بتعمل + +113 +00:09:58,420 --> 00:10:01,600 +Infiltration في الأنسجة من الأماكن اللي بيصير فيها + +114 +00:10:01,600 --> 00:10:07,990 +Infiltration الجمكلوراما تلون في الجلد زي ما انتوا + +115 +00:10:07,990 --> 00:10:14,970 +شايفين تلون في الجلد طيب + +116 +00:10:14,970 --> 00:10:20,830 +نيجي للـ Leukostasis اش Leukostasis هذه؟ ممكن الـ + +117 +00:10:20,830 --> 00:10:26,670 +Blast Cells هذه تعمل تتجمع مع بعض وتروح وقفة في + +118 +00:10:26,670 --> 00:10:29,630 +الـ microcirculation في الـ circulations الدقيقة + +119 +00:10:30,490 --> 00:10:34,130 +فبتعمل زي Impulse إيش يعني Impulse؟ زي جلطة صغيرة + +120 +00:10:34,130 --> 00:10:38,090 +بس من الـ Blast طبعاً هذه هتأثر على الـ Perfusion + +121 +00:10:38,090 --> 00:10:41,110 +للعضو هتأثر على كمية الـ Blood اللي واصلة للعضو + +122 +00:10:41,110 --> 00:10:45,250 +إيش هينتج عنه؟ ممكن لو مثلا قلنا في الـ Lung ممكن + +123 +00:10:45,250 --> 00:10:50,250 +يصير Hypoxemia Bulmonary Infiltrate هتنتقل هذه + +124 +00:10:50,250 --> 00:10:54,670 +للخلايا وممكن تنتشر في الـ Lung ممكن يصير Hypoxia + +125 +00:10:54,670 --> 00:10:57,210 +في الـ Lung الـ Central Nervous System ممكن تعمل + +126 +00:10:57,210 --> 00:11:00,620 +Stroke يعني ممكن إيش تعمل؟ اتسددأحد الشرايين + +127 +00:11:00,620 --> 00:11:06,460 +الرئيسية المغذية للدماغ وتعمل جلطة دماغية طيب ها + +128 +00:11:06,460 --> 00:11:09,260 +دي بقولك إنها بس بتبين إذا كانت ال «white pieces» + +129 +00:11:09,260 --> 00:11:11,240 +أو بتصير إذا كانت ال «white pieces» عددها فوق + +130 +00:11:11,240 --> 00:11:14,940 +الخمسين ألف «hyperleukocytosis» إذا كان عدد ال + +131 +00:11:14,940 --> 00:11:20,140 +«white pieces» فوق الخمسين ألف من الأشياء السيئة + +132 +00:11:20,140 --> 00:11:24,540 +اللي ممكن تعملها اللوكيميا خلال فترة العلاج أنه + +133 +00:11:24,540 --> 00:11:29,510 +بتدور إليها على sanctuary siteإيش يعني sanctuary + +134 +00:11:29,510 --> 00:11:35,590 +site؟ مكان أو ملاذ آمن الآن خلال فترة العلاج اللي + +135 +00:11:35,590 --> 00:11:39,530 +بياخده المريض في أماكن ممكن ما يوصل لها هذا العلاج + +136 +00:11:39,530 --> 00:11:43,210 +اللي هو الـ Cytotoxic Drug العلاج الكيموي والأدوية + +137 +00:11:43,210 --> 00:11:47,610 +هذه في أماكن ممكن ما توصل لها زي ash زي الـ Testis + +138 +00:11:47,610 --> 00:11:50,890 +والـ Meninges هذه الأماكن ما بوصل لها العلاج + +139 +00:11:50,890 --> 00:11:57,810 +فبالتالي الخلايا بتروح و بتختفي هناك بتقعد في هذا + +140 +00:11:57,810 --> 00:12:01,150 +المكانإذا كانت موجودة الخلايا وعمل Infiltration في + +141 +00:12:01,150 --> 00:12:05,970 +هذا المكان مش راح يوصل لها العلاج الآن المريض أخد + +142 +00:12:05,970 --> 00:12:10,430 +العلاج وخلص واتعافى الخلايا دي لازالت موجودة ممكن + +143 +00:12:10,430 --> 00:12:15,330 +تطلع وتعمل Relapse تعمل عودة للمرض وهذه شائعة في + +144 +00:12:15,330 --> 00:12:18,710 +الـ Childhood ALL في حالات الـ Acute Lymphoblastic + +145 +00:12:18,710 --> 00:12:22,430 +Disease السبب التالت من الأسباب اللي بتكون Harmful + +146 +00:12:22,430 --> 00:12:24,790 +في اللوكيميا وتؤدي إلى الوفاة اللي هي الـ + +147 +00:12:24,790 --> 00:12:29,600 +Metabolic Disturbancesإيش اللي ممكن يصير في حالات + +148 +00:12:29,600 --> 00:12:33,040 +اللوكيميا؟ أول حاجة الـ Hyponatremia إيش يعني + +149 +00:12:33,040 --> 00:12:36,600 +Hyponatremia نقص الصوديوم؟ طب من إيش بيصير نقص + +150 +00:12:36,600 --> 00:12:40,580 +الصوديوم؟ نقص الصوديوم بيجي في الحالات اللي بتبقى + +151 +00:12:40,580 --> 00:12:44,750 +فيها Myeloblast اللي هي الـAML عادةلأن الـ + +152 +00:12:44,750 --> 00:12:49,150 +Homoloblast بتفرز هرمون Vasopressin-like هرمون + +153 +00:12:49,150 --> 00:12:53,790 +شبيه بالـ Vasopressin هرمون هذا الهرمون بيؤدي إلى + +154 +00:12:53,790 --> 00:12:58,170 +هروب الكالسيوم عبر الكدن عفواً الـ Sodium من الكدن + +155 +00:12:58,170 --> 00:13:03,350 +فطبعاً هذا يؤدي إلى هروبه في الكدن هيؤدي إلى نقصه + +156 +00:13:03,350 --> 00:13:06,090 +في الـ circulation عشان هيك بتصير أنها حالة + +157 +00:13:06,090 --> 00:13:10,010 +Hyponatremia الشغل التاني Hypokalemia نقص + +158 +00:13:10,010 --> 00:13:13,950 +البوتاسيامنقص البوتاثين بيصير حال عادة في حالات + +159 +00:13:13,950 --> 00:13:19,010 +الـ M4 والـ M5 هي ممكن يكون جاي نتيجة خلل برضه في + +160 +00:13:19,010 --> 00:13:23,310 +الـ kidney طيب، شغلة رابعة، ارتفاع الـ Uric Acid + +161 +00:13:23,310 --> 00:13:26,670 +طب من إيش بيجي ارتفاع الـ Uric Acid؟ طب أن إحنا + +162 +00:13:26,670 --> 00:13:29,290 +عارفين الـ blood cells اللي بتكون عادة بتكون + +163 +00:13:29,290 --> 00:13:33,250 +fragile فممكن يتصيرلها spontaneous slices الـ + +164 +00:13:33,250 --> 00:13:35,790 +spontaneous slices هذه هيفرز كمية كبيرة من + +165 +00:13:35,790 --> 00:13:39,550 +البيورين في الـ circulationالكمية الكبيرة هذه ممكن + +166 +00:13:39,550 --> 00:13:43,150 +الكدني طبعاً هي هتتحول لـ Uric Acid الـ Uric Acid + +167 +00:13:43,150 --> 00:13:48,730 +هيشكل لودي كتير كبير على الكدني مش هتقدر تتخلص منه + +168 +00:13:48,730 --> 00:13:51,710 +بالشكل الكافي خاصة إذا كان أساساً فيه خلل في + +169 +00:13:51,710 --> 00:13:55,210 +الكيلية فبالتالي ممكن يكون خطير لدرجة إن الوريد + +170 +00:13:55,210 --> 00:14:01,160 +يحتاج غسيل كيلة نتيجة الشغلة هذهوبتضاعف المشكلة مع + +171 +00:14:01,160 --> 00:14:03,800 +الـ cytotoxic drugs الـ cytotoxic drugs اللي + +172 +00:14:03,800 --> 00:14:07,140 +بياخدوها المرضى هدال أول حاجة بتزيد ال license + +173 +00:14:07,140 --> 00:14:10,800 +للخلايا لأن هي الـ cytotoxic drugs هتموت الخلايا + +174 +00:14:10,800 --> 00:14:15,880 +اللي هي السرطانية تكسير الخلايا السرطانية هيزيد + +175 +00:14:15,880 --> 00:14:19,940 +الإفراز لبيورين وبالتالي هيزود اليوريك أسد + +176 +00:14:19,940 --> 00:14:24,480 +بالإضافة لأنه هيعطل النفران لأن الـ cytotoxic drug + +177 +00:14:24,480 --> 00:14:28,240 +برضه nefrotoxicفهيضاعف المشكلة اللي جاية من تكسير + +178 +00:14:28,240 --> 00:14:31,820 +الخلايا حتى لو كانت المشكلة بسيطة وجود الـ + +179 +00:14:31,820 --> 00:14:36,160 +Cytotoxic Drug وتأثيره على النفران تأثير سلبي + +180 +00:14:36,160 --> 00:14:41,940 +هيؤثر ويزود المشكلة ويوصلها إلى مراحل صعبة ممكن + +181 +00:14:41,940 --> 00:14:45,900 +تحتاج لـ Dialysis طيب، يعني بعد ما خلصنا الـ Acute + +182 +00:14:45,900 --> 00:14:49,340 +Leukemia بدنا نلخص الكلام اللي حكيناه في بعض + +183 +00:14:49,340 --> 00:14:53,500 +النقاط المهمة اللي بتنزمني في الـ Diagnosisأول + +184 +00:14:53,500 --> 00:14:57,380 +حاجة في الـ Acute Leukemia الـ Lab Finding أول + +185 +00:14:57,380 --> 00:15:04,320 +حاجة الـ White BCs عادة elevated بس لكن ممكن تكون + +186 +00:15:04,320 --> 00:15:08,420 +Normal أو لأ مش شرط إنها تبقى دايماً عالية ممكن + +187 +00:15:08,420 --> 00:15:11,660 +أشوف Blast في الـ Peripheral Blood بون مارو أكيد + +188 +00:15:11,660 --> 00:15:15,880 +لازم أشوف فيه Blast أكتر من 20% الأنيميا عادة + +189 +00:15:15,880 --> 00:15:20,070 +بتكون Normocytic Anemia لأنه خلل في التصنيعأشوف + +190 +00:15:20,070 --> 00:15:25,670 +أثرومبوسيتبينيا الـ Neutropenia ممكن تتطور لـ DIC + +191 +00:15:25,670 --> 00:15:30,430 +Bone + +192 +00:15:30,430 --> 00:15:32,910 +marrow in acute leukemia كيف بيكون وضع الـ bone + +193 +00:15:32,910 --> 00:15:36,110 +marrow طبعا الـ bone marrow إذا كان في acute + +194 +00:15:36,110 --> 00:15:39,570 +leukemia لازم نعملهلازم نعمله عشان نعمل diagnosis + +195 +00:15:39,570 --> 00:15:43,650 +ونحدد الـ type للـ leukemia ونعرف الـ prognosis + +196 +00:15:43,650 --> 00:15:46,590 +طبعا الـ acute leukemia are defined by the + +197 +00:15:46,590 --> 00:15:50,010 +presence of more than 20% blast in bone marrow + +198 +00:15:50,010 --> 00:15:53,750 +طبعا قلتلكم أكتر من 20% من خلايا الـ bone marrow + +199 +00:15:53,750 --> 00:16:01,990 +اللي هي الـ nucleated cells هتكون blast cells بدنا + +200 +00:16:01,990 --> 00:16:06,250 +نميز بين الـ AML والـ ALLبالـ Light Microscope + +201 +00:16:06,250 --> 00:16:10,510 +العادى الـ AML فيها أور رود فيها Cytoplasmic + +202 +00:16:10,510 --> 00:16:14,850 +Granules فيها بيروكسيداز Positive طبعا بالـ + +203 +00:16:14,850 --> 00:16:18,810 +Special Stain الـ ALL مافيش فيها أور رود + +204 +00:16:18,810 --> 00:16:23,450 +أوريجرانيال فيها الـ Myloberoxidase Negative والـ + +205 +00:16:23,450 --> 00:16:26,570 +BAS Positive ممكن أميز بشكل صحيح من خلال + +206 +00:16:26,570 --> 00:16:30,110 +Immunophenotyping باستخدام لـ Flow Cytometry ممكن + +207 +00:16:30,110 --> 00:16:31,810 +باستخدام Special Stain + +208 +00:16:35,940 --> 00:16:39,040 +الجزئية التانية اللي بنحكي فيها اللي هي الـ + +209 +00:16:39,040 --> 00:16:42,900 +Chronic Leukemia طبعا Chronic Leukemia بيصير + +210 +00:16:42,900 --> 00:16:46,680 +Clonal expansion of white blood cells are taking + +211 +00:16:46,680 --> 00:16:49,420 +place in the bone marrow بيصير زيادة في الـ white + +212 +00:16:49,420 --> 00:16:53,720 +blood cells لنوع معين من الخلايا طبعا حسب نوع + +213 +00:16:53,720 --> 00:16:58,240 +الخلايا اللي صار فيه الخلل بصنفها لـ Lymphoid و + +214 +00:16:58,240 --> 00:17:01,760 +Myeloid Chronic Lymphocytic Leukemia وChronic + +215 +00:17:01,760 --> 00:17:03,720 +Myelocytic Leukemia + +216 +00:17:36,510 --> 00:17:40,730 +نشوف الـ incidence of chronic leukemia الـ chronic + +217 +00:17:40,730 --> 00:17:45,610 +lymphoid leukemia 90% من حالتها بشوفها في الناس في + +218 +00:17:45,610 --> 00:17:50,370 +سن الخمسينات أو أكتر متوسط العمر عند الـ diagnosis + +219 +00:17:50,370 --> 00:17:55,250 +خمسة و ستين سنة ال incidence of the disease + +220 +00:17:55,250 --> 00:17:59,610 +increase with age يعني مع العمر فرصة حدوث المرض + +221 +00:17:59,610 --> 00:18:03,610 +بتزيد it is almost never seen in children يعني هذه + +222 +00:18:03,610 --> 00:18:07,220 +عادة مابشوفهاش نهائيا عند الأطفالالـ Chronic + +223 +00:18:07,220 --> 00:18:11,020 +Myeloid Leukemia عادةً بتوصف يعني بتكون في منتصف + +224 +00:18:11,020 --> 00:18:16,000 +الأربعينيات من العمر ممكن تشكل 4% من حالات + +225 +00:18:16,000 --> 00:18:20,600 +اللوكيميا عند الأطفال نيجي للـ Lab Diagnosis of + +226 +00:18:20,600 --> 00:18:24,240 +Leukemia أول حاجة الـ Chronic Lymphocytic Leukemia + +227 +00:18:24,240 --> 00:18:28,280 +peripheral blood في الـ peripheral blood بشوف + +228 +00:18:28,280 --> 00:18:32,900 +ارتفاع في الـ lymphocyte lymphocytosis بشوف + +229 +00:18:32,900 --> 00:18:41,950 +thrombocytopeniaانخفاض في الـ Platelets أنيميا الـ + +230 +00:18:41,950 --> 00:18:47,370 +CLL تتميز بوجود خلية اللي هي بسميها Smudge Cell + +231 +00:18:47,370 --> 00:18:50,310 +لأنها هي الـ Cell اللي موجودة في هذه الخلية + +232 +00:18:50,310 --> 00:18:54,790 +Fragile Cell فبتلاقيها بسرعة بيتغير شكلها بتنهرس + +233 +00:18:54,790 --> 00:18:58,950 +خلال الفرد The blood smear could show many + +234 +00:18:58,950 --> 00:19:02,290 +abnormal looking lymphocyte called Smudge Cell + +235 +00:19:02,290 --> 00:19:06,420 +اللي هي مخد هذا الشكلشايفين كيف؟ خلية بتحس إنها بس + +236 +00:19:06,420 --> 00:19:10,360 +نواة مافيش فيها أي معالم تانية كأنه الـ cytoplasm + +237 +00:19:10,360 --> 00:19:15,020 +انهرس خلال الفرد الـ bone marrow عادة بيكون + +238 +00:19:15,020 --> 00:19:18,920 +hypercellular بلاقي فيه زيادة في الـ mature + +239 +00:19:18,920 --> 00:19:21,980 +lymphocyte طيب إيش وضع الـ blast؟ مافيش عندى blast + +240 +00:19:21,980 --> 00:19:26,180 +لأنها chronic الـ blast بيكون عددها قليل جدا يعني + +241 +00:19:26,180 --> 00:19:29,820 +مابيكون فيه عندى blast بشكل ملحوظ زي الـ acute + +242 +00:19:35,270 --> 00:19:38,530 +في عندي أنواع نادرة من الـ Lymphocytic Leukemia + +243 +00:19:38,530 --> 00:19:42,970 +اللي هي الـ Pro-Lymphocytic Leukemia إحنا من ناحية + +244 +00:19:42,970 --> 00:19:47,530 +Morphology قد نميز الـ Lymphocyte إلى 3 مراحل اللي + +245 +00:19:47,530 --> 00:19:51,470 +هي Lymphoblast و Pro-Lymphocyte و Lymphocyte + +246 +00:19:51,470 --> 00:19:55,410 +وقلتلكم إن هذه المراحل كتير في تشابه بينها عشان + +247 +00:19:55,410 --> 00:19:58,250 +هيك أفضل إشي بنميز بينهم من خلال الـ + +248 +00:19:58,250 --> 00:20:02,090 +Immunophenotyping و الـ Cell Markers اللي بتظهر في + +249 +00:20:02,090 --> 00:20:06,110 +كل مرحلة من مراحل الـ Maturation للخليةالـ Pro + +250 +00:20:06,110 --> 00:20:10,370 +-lymphocytic leukemia بلاقي زيادة من الـ Pro + +251 +00:20:10,370 --> 00:20:13,470 +-lymphocyte يعني الـ cancers اللي الموجودة هي Pro + +252 +00:20:13,470 --> 00:20:18,030 +-lymphocyte هي عبارة عن immature form of B or T + +253 +00:20:18,030 --> 00:20:20,990 +-lymphocyte عبارة عن خلية immature يعني مش ال + +254 +00:20:20,990 --> 00:20:24,490 +mature form لأ المرحلة اللي قبلها طبعا ما بلاقي + +255 +00:20:24,490 --> 00:20:27,330 +فيها blast عشان هيك أو بيكون عدد ال blast normal + +256 +00:20:27,330 --> 00:20:29,730 +أو قليل عشان هيك بتعتبر chronic + +257 +00:20:33,920 --> 00:20:38,000 +من الأنواع الأخرى اللي بتعتبر «Rare of lymphoid + +258 +00:20:38,000 --> 00:20:41,980 +leukemia» «Rare type of lymphoid chronic leukemia» + +259 +00:20:41,980 --> 00:20:45,960 +الـ Hairy cell leukemia Hairy cell leukemia عبارة + +260 +00:20:45,960 --> 00:20:50,700 +عن cancer of lymphocyte هذا النوع بـ Progress + +261 +00:20:50,700 --> 00:20:55,720 +slowly يعني يتطور عند الإنسان ببطء الـ Cancer cell + +262 +00:20:55,720 --> 00:21:00,170 +عبارة عن B lymphocyteالـ Cancer Cell عبارة عن Ash + +263 +00:21:00,170 --> 00:21:04,010 +B-Lymphocyte لكن مختلفة عن الخلايا الموجودة في الـ + +264 +00:21:04,010 --> 00:21:08,550 +CLL هنا في اختلاف في الأعراض، اختلاف في الـ + +265 +00:21:08,550 --> 00:21:13,070 +Treatment شغلة تانية، من وين أجى اسمها الـ Hair + +266 +00:21:13,070 --> 00:21:17,830 +Cell إن الخلية هنا تكتسب مجموعة من الـ Projections + +267 +00:21:17,830 --> 00:21:21,850 +أو الذوائد علق من الطلعة من الـCytoplasm على شكل + +268 +00:21:21,850 --> 00:21:26,270 +الـHairs، على شكل شعيرات صغيرةفعشان هيك صار اسمها + +269 +00:21:26,270 --> 00:21:30,190 +Hairy أو أجى اسمها Hairy Cell Leukemia هذه الـ + +270 +00:21:30,190 --> 00:21:32,690 +Hairy Cell Leukemia بتتميز بإنه بيصير + +271 +00:21:32,690 --> 00:21:36,350 +Myelofibrosis بنلاحظ إن الـ bone marrow في هذا + +272 +00:21:36,350 --> 00:21:40,430 +النوع من الأنيميا من اللوكيميا الـ bone marrow كل + +273 +00:21:40,430 --> 00:21:44,810 +ال parameters فيه very low الـRBCs والهمoglobin + +274 +00:21:44,810 --> 00:21:48,250 +الـRBCs، كل الـCBC بتلاقيه واطية الـplatelets + +275 +00:21:48,250 --> 00:21:52,080 +بتلاقيها واطيةالـ YPCs Count برضه بتلاقي واطي + +276 +00:21:52,080 --> 00:21:55,440 +الخلية الـ Predominant اللي هي الـ Hairy Cell إيش + +277 +00:21:55,440 --> 00:21:59,880 +هي الـ Hairy Cell؟ عبارة عن B-Lymphocyte مخدة الـ + +278 +00:21:59,880 --> 00:22:05,840 +Hairy Projection نوع تاني برضه من الـ Chronic + +279 +00:22:05,840 --> 00:22:09,380 +Lymphocytic Leukemia اللي هي Large Granular + +280 +00:22:09,380 --> 00:22:13,740 +Lymphocytic Leukemia طبعاً هذا نوع آخر من الـ + +281 +00:22:13,740 --> 00:22:17,660 +Chronic Leukemia الخلية نفسها هذه هي الـ Natural + +282 +00:22:17,660 --> 00:22:23,830 +Killer Cellاللي هي طبعاً بتقوم بواقع ضائف معينة في + +283 +00:22:23,830 --> 00:22:27,170 +الجسم ممكن هي نفسها يصير فيها cancer خلية كبيرة + +284 +00:22:27,170 --> 00:22:32,810 +فيها بعض الـ granules المميزة لإلها معظم أنواعها + +285 +00:22:32,810 --> 00:22:37,950 +ممكن تكون slow growing يعني بطيقة لكن في عدد قليل + +286 +00:22:37,950 --> 00:22:41,950 +منها ممكن يبقى rapid and aggressive ممكن يكون + +287 +00:22:42,640 --> 00:22:48,040 +الخلايا الشديدة الانقسام وسريعة الانتشار لكن بشكل + +288 +00:22:48,040 --> 00:22:56,020 +عام هي بطيقة التطور وبطيقة التكوين Chronic + +289 +00:22:56,020 --> 00:23:01,120 +Myelocytic Leukemia بالنسبة لهذا النوع من + +290 +00:23:01,120 --> 00:23:06,580 +الليوكيميا هنلاقي فيه expansion للـgranulocytic + +291 +00:23:06,580 --> 00:23:10,520 +precursors يعني هتلاقي كل ال immature forms تعتلي + +292 +00:23:10,520 --> 00:23:14,720 +granulocyte موجودةwithout regulation، يعني هتلاقي + +293 +00:23:14,720 --> 00:23:18,500 +عندك Bromelocyte، هتلاقي Metamelocyte، في الـ + +294 +00:23:18,500 --> 00:23:22,720 +Peripheral Blood وفي الـ Bone marrow، هتلاقي بعدها + +295 +00:23:22,720 --> 00:23:26,760 +Metamelocyte، هتلاقي Band Cells، طبعا أنا مابحكيش + +296 +00:23:26,760 --> 00:23:29,800 +بس Neutrophil، هتلاقي كله، هتلاقي Xenophil، هتلاقي + +297 +00:23:29,800 --> 00:23:34,870 +Bezophil، هتلاقي Neutrophilهتلاقي mature farms + +298 +00:23:34,870 --> 00:23:37,430 +يعني هتلاقي كل الـ precursors بتاعة الـ + +299 +00:23:37,430 --> 00:23:39,530 +granulocyte موجودة في الـ peripheral blood صارت + +300 +00:23:39,530 --> 00:23:43,130 +عندك بعدد كبير وحتى هتلاقي عدد الـ YPCs عندك عالي + +301 +00:23:43,130 --> 00:23:48,990 +كثير البرضه الـ megakaryocytobiosis هيصير فيه + +302 +00:23:48,990 --> 00:23:53,050 +expansion يعني هيزيد و هيزيد العدد اللي بتتكون و + +303 +00:23:53,050 --> 00:23:55,810 +غالباً بتلاقي الـ platelets في هذه الحالات عالية + +304 +00:23:55,810 --> 00:24:00,730 +erythropoiesis هيصير فيه defect هيصير فيه نقص في + +305 +00:24:00,730 --> 00:24:04,100 +عدد ال RBCsfunction of the neutrophil والـ + +306 +00:24:04,100 --> 00:24:07,200 +platelets عادة يعني بتكون تقريبا normally يعني ما + +307 +00:24:07,200 --> 00:24:11,140 +بتتأثر ال function لإنها في المعظم حالات الـCML + +308 +00:24:11,140 --> 00:24:14,240 +هنلاقي عندهم الـ Philadelphia chromosome + +309 +00:24:14,240 --> 00:24:18,480 +Philadelphia chromosome هذا عبارة عن أو جاي من + +310 +00:24:18,480 --> 00:24:24,540 +translocation لقطع من كرمزوم 9 إلى كرمزوم 22طبعاً + +311 +00:24:24,540 --> 00:24:28,320 +في قطعة من كروموزوم 22 هتروحها كروموزوم 9 هذا مش + +312 +00:24:28,320 --> 00:24:32,040 +راح يعمل إشي بس اللي هيشتغل اللي هو التركيبة + +313 +00:24:32,040 --> 00:24:34,940 +الجديدة لكروموزوم 22 اللي بيسمى بالفلادلفيا + +314 +00:24:34,940 --> 00:24:39,880 +كروموزوم ناتج عن انتقال قطعة الـ ABL من كروموزوم 9 + +315 +00:24:39,880 --> 00:24:44,980 +إلى كروموزوم 22 هذه التركيبة اللي بيسموها PCR-ABL + +316 +00:24:44,980 --> 00:24:51,580 +هذه عادةً وجدوا إنه لها Tyrosine Kinase Activity + +317 +00:24:52,020 --> 00:24:55,580 +فهي بتحفز انقسام الخلايا وتكثرها عشان هيك بيزيد + +318 +00:24:55,580 --> 00:25:00,980 +عدد الخلايا و بيصير uncontrolled معظم المرضى اللي + +319 +00:25:00,980 --> 00:25:03,660 +عندهم CML بيلاقوا عندهم الـ Philadelphia + +320 +00:25:03,660 --> 00:25:06,960 +chromosome فبالتالي سهل إنهم يعالجوهم كيف + +321 +00:25:06,960 --> 00:25:11,420 +بيعالجوهم؟ بيعالجوهم عن طريق Anti-Tyrosine Kinase + +322 +00:25:11,420 --> 00:25:15,020 +بيعطوهم مضاد للـTyrosine Kinase فبوقف ال activity + +323 +00:25:15,020 --> 00:25:18,820 +لإلهالآن الناس اللي ما عندهم مشهاد الـ mutation + +324 +00:25:18,820 --> 00:25:22,880 +بيكون وضعهم أصعب شوية يعني مرضى الـCML اللي عندهم + +325 +00:25:22,880 --> 00:25:25,940 +Philadelphia chromosome بيلاقوا علاج أفضل من اللي + +326 +00:25:25,940 --> 00:25:28,900 +ما عندهم Philadelphia chromosome مش كل مرضى الـCML + +327 +00:25:28,900 --> 00:25:32,980 +عندهم الـPhiladelphia chromosome positive طيب، + +328 +00:25:32,980 --> 00:25:40,000 +ننتقل إلى ال phases of CML الـphase الأولى اللي هي + +329 +00:25:40,000 --> 00:25:45,260 +الـchronic phase بنلاقي الـblast cellsعددها أقل من + +330 +00:25:45,260 --> 00:25:48,280 +10% في الـ Peripheral blood مانلاقيش Blast كتير + +331 +00:25:48,280 --> 00:25:54,300 +وهذه المرحلة ممكن تظل فترة طويلة لكن ممكن تقلب + +332 +00:25:54,300 --> 00:25:59,540 +لمراحل اللي بعدها المرحلة اللي بعدها ممكن تيجي + +333 +00:25:59,540 --> 00:26:02,500 +اللي هي الـ Accelerated phase بلاقي الـ Blast + +334 +00:26:02,500 --> 00:26:06,780 +Cells بلش هتتزيد ممكن توصل لـ 30% في الـ + +335 +00:26:06,780 --> 00:26:10,020 +Peripheral blood أو في البولمروالـ platelets ممكن + +336 +00:26:10,020 --> 00:26:13,640 +تكون very low أقل من 100 ألف أو أكتر من مليون أو + +337 +00:26:13,640 --> 00:26:19,240 +عالية كتير في عندي أشياء تانية ممكن ألاقيها لو + +338 +00:26:19,240 --> 00:26:23,820 +أجيت عملت الـ cytogenetic studies حلائق الفلادلفيا + +339 +00:26:23,820 --> 00:26:30,480 +كروموزام حلائق splenomegaly عند هدول الناس هذه الـ + +340 +00:26:30,480 --> 00:26:33,820 +accelerated phase هذه الـ accelerated phase ممكن + +341 +00:26:33,820 --> 00:26:40,410 +تتطور للـ blast crisis هنا حلائقأكتر من 30% بلاست + +342 +00:26:40,410 --> 00:26:44,650 +في الـ Peripheral blood في البون مرو البلاست لو + +343 +00:26:44,650 --> 00:26:48,570 +أجيت عملت بون مرو بيوبسي هلاقي كميات كبيرة من + +344 +00:26:48,570 --> 00:26:52,650 +البلاست في البون مرو بيوبسي بالاضافة لإنه ممكن + +345 +00:26:52,650 --> 00:26:56,270 +تعمل Extra Medullary Infiltration اللي بلاست سلس + +346 +00:26:56,270 --> 00:27:00,610 +هذه تنتقل أماكن أخرى خارج البون مرو تعمل + +347 +00:27:00,610 --> 00:27:04,710 +Infiltration نيجي + +348 +00:27:04,710 --> 00:27:11,090 +إيش بنشوف عند المريض هذا؟أول حاجة الـ CPC الـ CPC + +349 +00:27:11,090 --> 00:27:17,430 +عادة الـ White PCs عندهم عالية عالية كتير يعني + +350 +00:27:17,430 --> 00:27:23,950 +غالبا بتكون أكتر من 50 ألف ممكن تزيد عن 500 ألف + +351 +00:27:23,950 --> 00:27:28,530 +يعني أحيانا بنعمل dilution أكتر عالي للعين عشان + +352 +00:27:28,530 --> 00:27:31,930 +يقدر الجهاز يعدها تبقى طبقة الـ White PCs عندهم + +353 +00:27:31,930 --> 00:27:37,540 +عالية جدا مرضى الـ CML هذه شغلةهيصير عندهم أنيميا + +354 +00:27:37,540 --> 00:27:41,880 +لأنه فيه defective erythropoiesis أشنع الأنيميا + +355 +00:27:41,880 --> 00:27:46,240 +هذه خلل في التصنيع فهتكون normocytic normochromic + +356 +00:27:46,240 --> 00:27:49,240 +يعني مش هيكون فيها إيبوكراميا أو لأ هتكون + +357 +00:27:49,240 --> 00:27:53,000 +normocytic normochromic أنيميا بالنسبة + +358 +00:27:53,000 --> 00:27:57,900 +للـplatelets الـplatelets variable يعني ممكن تبقى + +359 +00:27:57,900 --> 00:28:03,460 +high ممكن تبقى normal ممكن تبقى low لو جينا + +360 +00:28:03,460 --> 00:28:06,650 +للـperipheral blood filmفي الـ Prefrontal Blast + +361 +00:28:06,650 --> 00:28:12,070 +Film هنلاقي Circulating Myeloid Precursors بكمية + +362 +00:28:12,070 --> 00:28:16,350 +كبيرة بالاضافة لوجود Bezophil يعني لو جينا هنا + +363 +00:28:16,350 --> 00:28:20,490 +هنلاقي كل الـ Precursors بتاعة الـ Granulocyte + +364 +00:28:20,490 --> 00:28:26,030 +موجودة هنلاقي برو .. طبعا Blast لأ مش هنلاقي Blast + +365 +00:28:26,030 --> 00:28:29,950 +هنلاقي Bromelocyte مثلاً هنلاقي Myeloid Cells + +366 +00:28:29,950 --> 00:28:34,630 +هنلاقي Metamyelocyte هنلاقي Bandطبعاً هدول إذا + +367 +00:28:34,630 --> 00:28:38,110 +كنتوا فاكرين عبارة عن الـNucleated RBCs اللي هنا + +368 +00:28:38,110 --> 00:28:42,890 +ممكن ألاقي بيزوفيليا ممكن ألاقي Band Cells ممكن + +369 +00:28:42,890 --> 00:28:46,550 +ألاقي Mature Cells هذه Metamyelocyte هذه مثلا + +370 +00:28:46,550 --> 00:28:52,970 +Myelocyte وها كذا، يعني ممكن أشوف عندي كل الـ + +371 +00:28:52,970 --> 00:28:58,750 +Maturation Stages بتاعة الـMyeloid Precursors في + +372 +00:28:58,750 --> 00:29:03,470 +الـBlood Film لهم، وهذا الفيلمبتذكر أنا لما درستكم + +373 +00:29:03,470 --> 00:29:07,230 +الـ Hematology جبتلكم فيلم مطابق لهذا اللي شبكتلكم + +374 +00:29:07,230 --> 00:29:10,210 +إياه على الكاميرا ومن الكاميرا ميكروسكوب وكاميرا + +375 +00:29:10,210 --> 00:29:14,750 +ومن الكاميرا على الصبورة وصرت أعرضلكم بعض الخلايا + +376 +00:29:14,750 --> 00:29:20,110 +كان فيلم «CML» يعني كانت حالة اتعلمنا من خلالها كل + +377 +00:29:20,110 --> 00:29:23,230 +الـ Maturation Stages على داك الفيلم إذا كنتوا + +378 +00:29:23,230 --> 00:29:28,770 +فاكرين تمام؟ هيك يا بنات بنكون إحنا مرينا على + +379 +00:29:28,770 --> 00:29:32,830 +اللوكيميا بأنواعهامرّينا على الـ Acute Leukemia + +380 +00:29:32,830 --> 00:29:37,870 +Acute Myeloid Acute Lymphocytic Leukemia وأخدنا + +381 +00:29:37,870 --> 00:29:42,990 +تقسيماتها وتصنيفاتها تقسيماتها إما حسب الـ + +382 +00:29:42,990 --> 00:29:47,630 +Morphology أو حسب الـ Immunophenotyping أو حسب الـ + +383 +00:29:47,630 --> 00:29:52,390 +Cytogenetic Studies الخاصة بالخلايا وبعد هيك + +384 +00:29:52,390 --> 00:29:56,670 +مرّينا على الـ Chronic Leukemia برضه بتقسيماتها + +385 +00:29:56,670 --> 00:30:02,570 +وبالأشياء اللي يعني ممكن نشوفها فيهاقلنا إنها قد + +386 +00:30:02,570 --> 00:30:08,450 +تكون lymphoid أو myeloid طبعا الـ lymphoid أخدنا + +387 +00:30:08,450 --> 00:30:11,890 +النوع الأساسي chronic lymphocytic leukemia وفي عند + +388 +00:30:11,890 --> 00:30:16,430 +بعض الأنواع أقل شيوعا زي الـ prolymphocytic + +389 +00:30:16,430 --> 00:30:22,190 +leukemia حكينا عنها و ال large cell leukemia اللي + +390 +00:30:22,190 --> 00:30:25,530 +فيها natural killer cells حكينا عن الhair cell + +391 +00:30:25,530 --> 00:30:32,180 +leukemia وقلنا إنه لها شكل مميز للخلايابعد هيك + +392 +00:30:32,180 --> 00:30:37,640 +انتقلنا للـCML وأخدنا الـChronic Myeloid Leukemia + +393 +00:30:37,640 --> 00:30:41,820 +إيش صفاتها وإيش خصائصها هيك بنقدر نقول إن إحنا + +394 +00:30:41,820 --> 00:30:45,060 +غطينا اللوكيميا وإن شاء الله في المراحل القادمة + +395 +00:30:45,060 --> 00:30:49,920 +راح نحاول نتعرف على إنه أنا بدي أكون بارعة في + +396 +00:30:49,920 --> 00:30:54,020 +الـDiagnosis لحالات اللوكيميا كيف أنا أحدد + +397 +00:30:54,020 --> 00:30:58,080 +الـDiagnosis كيف أنا يعني أربط الأمور مع بعض وأعرف + +398 +00:30:58,080 --> 00:31:02,220 +التشخيص النهائي لحالة اللوكيميابيعطيكم ألف عافية + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk.srt new file mode 100644 index 0000000000000000000000000000000000000000..3b144c92a8cd2247fdff65d00acecbc0d42528a6 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk.srt @@ -0,0 +1,1908 @@ +1 +00:00:13,100 --> 00:00:17,020 +نستكمل نبدأ الآن إن شاء الله رب العالمين مع ال + +2 +00:00:17,020 --> 00:00:21,040 +bleeding disorders نأخذ فكرة عنها ونشوف كيف بدنا + +3 +00:00:21,040 --> 00:00:27,080 +نعمل لها diagnosis ونفرقها عن بعض المشاكل + +4 +00:00:27,080 --> 00:00:32,000 +اللي ممكن تصير في ال bleeding قد تكون جاية من خلل + +5 +00:00:32,000 --> 00:00:36,100 +في ال coagulation factors أو خلل في ال platelets + +6 +00:00:36,100 --> 00:00:43,000 +خلينا نعمل مقارنة بسيطة بينهم بين الأعراض بداية + +7 +00:00:43,000 --> 00:00:46,020 +البلاتلات الـ disorders والـ coagulation + +8 +00:00:46,020 --> 00:00:50,940 +disorders نشوف أول حاجة الـ site of bleeding عادة + +9 +00:00:50,940 --> 00:00:55,360 +البلاتلات الـ disorders بتبقى الأماكن اللي بيصير + +10 +00:00:55,360 --> 00:00:59,900 +فيها ال bleeding عادة سطحية يعني في ال skin، في ال + +11 +00:00:59,900 --> 00:01:06,920 +mucous membrane زي ابستاكسز، gum، vaginal، GIT، + +12 +00:01:06,920 --> 00:01:10,400 +bleeding يعني في أماكن وين في ميوكاس membrane أو + +13 +00:01:10,400 --> 00:01:13,620 +skin ممكن تظهر بينما الـ Coagulation Factor + +14 +00:01:13,620 --> 00:01:16,800 +Disorders بتكون في أماكن عميقة زي الـ joints والـ + +15 +00:01:16,800 --> 00:01:21,680 +muscles بالتأكيد في الـ Platelet Disorder بتكون + +16 +00:01:21,680 --> 00:01:25,580 +واضحة بينما في الـ Coagulation Factor Disorders لأ + +17 +00:01:25,580 --> 00:01:30,740 +الـ Echemosis اللي هي الكدمات الزرقاء الكبيرة عادة + +18 +00:01:30,740 --> 00:01:34,560 +يعني في الـ Platelets بتكون صغيرة و superficial + +19 +00:01:34,560 --> 00:01:38,560 +بينما في الـ Coagulation Factor Disorders بتكون + +20 +00:01:38,560 --> 00:01:43,230 +large and deep Hemarthrosis أو Muscle bleeding اللي + +21 +00:01:43,230 --> 00:01:47,390 +هو تجمع دموي في المفاصل أو في العضلات في + +22 +00:01:47,390 --> 00:01:50,510 +الـplatelet disorder extremely rare بينما في + +23 +00:01:50,510 --> 00:01:54,710 +الـcoagulation factor أساسي bleeding after cut or + +24 +00:01:54,710 --> 00:01:59,590 +scratches عادة الجروح السطحية البسيطة لو كان في + +25 +00:01:59,590 --> 00:02:03,670 +platelet disorder بتظل تنزف بينما في + +26 +00:02:03,670 --> 00:02:06,470 +الـcoagulation factor disorders عادة ما بيصيرش + +27 +00:02:06,470 --> 00:02:10,640 +منها مشاكل الـ bleeding after surgery or trauma + +28 +00:02:10,640 --> 00:02:16,480 +عادة بيكون immediate bleeding وبيكون يعني خفيف + +29 +00:02:16,480 --> 00:02:21,960 +ما بيكونش كتير بينما بعد العمليات الجراحية إذا كان + +30 +00:02:21,960 --> 00:02:25,560 +فيه خلل في ال coagulation factor بيصير ال bleeding + +31 +00:02:25,560 --> 00:02:31,160 +متأخر يعني ما بيصيرش في الحال ومن يوم إلى يومين بعد + +32 +00:02:31,160 --> 00:02:35,260 +العملية وعادة بيكون severe بيكون صعب ومضاعفات + +33 +00:02:35,260 --> 00:02:35,680 +خطيرة + +34 +00:02:38,940 --> 00:02:43,360 +من الـ Coagulation Factor Disorders نوعين نوع + +35 +00:02:43,360 --> 00:02:47,420 +Inherited و نوع Acquired الـ Inherited زي اللي + +36 +00:02:47,420 --> 00:02:51,720 +إحنا عارفينهم بشكل عام الـ Factor Deficiencies من + +37 +00:02:51,720 --> 00:02:55,800 +الـ Factor Deficiencies الأكثر شيوعًا Hemophilia A + +38 +00:02:55,800 --> 00:03:00,940 +و Hemophilia B في عندي الـ Von Willebrand Disease في + +39 +00:03:00,940 --> 00:03:04,520 +عندي Acquired Disorders زي Liver Disease و Vitamin + +40 +00:03:04,520 --> 00:03:09,640 +K Deficiency أو الناس اللي بتأخذ وارفارين Overdose + +41 +00:03:09,640 --> 00:03:18,560 +يعني أخذت وارفارين كمية كبيرة حالات الـ DIC طيب + +42 +00:03:18,560 --> 00:03:22,360 +نيجي مقارنة بسيطة بين Hemophilia A و Hemophilia B + +43 +00:03:22,360 --> 00:03:26,120 +زي ما إحنا عارفين Hemophilia A بيكون خلل في factor + +44 +00:03:26,120 --> 00:03:30,760 +8 Hemophilia B بيبقى فيه خلل أو نقص في factor 9 + +45 +00:03:30,760 --> 00:03:37,180 +طريقة التوريث كلاهما X-linked recessive ال + +46 +00:03:37,180 --> 00:03:43,130 +incidence Hemophilia A 1 على 10 ألف Hemophilia B 1 + +47 +00:03:43,130 --> 00:03:47,770 +على 50 ألف Male يعني هذه أقل شيوعًا اللي هي + +48 +00:03:47,770 --> 00:03:54,170 +Hemophilia B Severity طبعًا بترجع لقداش صار + +49 +00:03:54,170 --> 00:03:59,110 +deficiency في ال factor إذا كانت كمية ال factor + +50 +00:03:59,110 --> 00:04:03,430 +الموجودة أقل من 1% هتلاقي severe spontaneous + +51 +00:04:03,430 --> 00:04:07,280 +bleeding لو كانت كمية الـ Factor الموجودة من 1 إلى + +52 +00:04:07,280 --> 00:04:12,260 +5% moderate bleeding with mild injury مع الجروح + +53 +00:04:12,260 --> 00:04:17,840 +البسيطة ممكن يصير bleeding من 5 إلى 25% mild + +54 +00:04:17,840 --> 00:04:20,680 +bleeding with surgery or trauma بس يعني بيصير + +55 +00:04:20,680 --> 00:04:24,920 +bleeding خفيف مع الضربات الكبيرة أو مع حدوث عمليات + +56 +00:04:24,920 --> 00:04:28,960 +جراحية الـ Complications عادة it and then بيصير + +57 +00:04:28,960 --> 00:04:34,580 +لهم complications إنه بيصير soft tissue bleeding طيب + +58 +00:04:34,580 --> 00:04:38,800 +الـ hemophilia الـ clinical manifestations طبعًا A + +59 +00:04:38,800 --> 00:04:44,440 +and B بالأعراض صعب أنه أفرقهم لازم أعمل factor الـ + +60 +00:04:44,440 --> 00:04:48,880 +C عشان أعرف المشكلة وين أول حاجة hemarthrosis + +61 +00:04:48,880 --> 00:04:52,660 +بيصير تجمع دموي في المفاصل نتيجة حركة المفاصل + +62 +00:04:52,660 --> 00:04:58,260 +بيصير زي تمزق في blood vessels هذا التمزق بينشأ + +63 +00:04:58,260 --> 00:05:03,220 +عنه bleeding يؤدي إلى تجمع blood في المفصل فبتحول + +64 +00:05:03,220 --> 00:05:07,480 +المفصل كأنه fixed joint يعني المفصل هذا صعب يتحرك + +65 +00:05:07,480 --> 00:05:12,380 +soft tissue hematoma تجمعات دموية في ال soft + +66 +00:05:12,380 --> 00:05:16,500 +tissue زي ال muscles ممكن هذا يؤدي لـ muscle atrophy + +67 +00:05:16,500 --> 00:05:22,800 +أو shortened tendons other sites of bleeding زي ال + +68 +00:05:22,800 --> 00:05:26,350 +urinary tract و ال central nervous system neck may + +69 +00:05:26,350 --> 00:05:30,510 +be life threatening ممكن يصير نزيف عنيف ويكون + +70 +00:05:30,510 --> 00:05:34,290 +خطير prolonged bleeding after surgery or dental + +71 +00:05:34,290 --> 00:05:37,710 +extraction يعني عادة هدول لما بيروحوا بيخلعوا + +72 +00:05:37,710 --> 00:05:42,310 +أسنانهم أو بيعملوا عمليات يعني حاجات في الفم أو + +73 +00:05:42,310 --> 00:05:50,390 +عمليات جراحية بسيطة هيصير عندهم bleeding ويطول هذا + +74 +00:05:50,390 --> 00:05:54,870 +منظر للـ hemarthrosis كيف تجمع دموي في المفصل + +75 +00:05:55,170 --> 00:05:59,070 +بيؤدي لانتفاخ المفصل لو أخلنا عينة من الـ + +76 +00:05:59,070 --> 00:06:02,370 +Synovial Fluid هنلاقي بلدي هنلاقي كمية ال blood + +77 +00:06:02,370 --> 00:06:06,450 +فيه كبيرة كبيرة + +78 +00:06:06,450 --> 00:06:11,010 +نيجي للـ Von Willebrand Disease الـ Von Willebrand + +79 +00:06:11,010 --> 00:06:14,050 +Disease طبعًا عبارة عن مرض من الأمراض الهيمستاسز + +80 +00:06:14,050 --> 00:06:17,050 +إحنا عارفين الـ Von Willebrand Factor بتصنع في الـ + +81 +00:06:17,050 --> 00:06:21,290 +Endothelium وفي الـ Platelets عادة بتصنع على شكل + +82 +00:06:21,290 --> 00:06:26,020 +مونومر وبيصير له polymerization في الـ Endoplasmic + +83 +00:06:26,020 --> 00:06:30,980 +reticulum للخلايا وفي الجولجي ابريتاس + +84 +00:06:30,980 --> 00:06:36,720 +وبيكون Large Multimer طبعًا وظائفه هو يعتبر كـ + +85 +00:06:36,720 --> 00:06:40,240 +Carrier لـ Factor 8 الشغلة الثانية المهمة اللي هي + +86 +00:06:40,240 --> 00:06:43,660 +بيثبت البلاتلت على الـ Subendothelium في بداية + +87 +00:06:43,660 --> 00:06:47,160 +مرحلة الـ Platelet Activation وبيعمل Bridging ما + +88 +00:06:47,160 --> 00:06:52,740 +بين البلاتلت بتم توريثه كـ Autosomal Dominant يعني + +89 +00:06:52,740 --> 00:06:56,300 +ما لهوش علاقة بالـ X-Promosome زي حالات الهيموفيليا + +90 +00:06:56,300 --> 00:07:03,060 +Autosomal Dominant Incidence من 1 إلى 10 ألف من + +91 +00:07:03,060 --> 00:07:08,000 +الـ Clinical Features تبعها نيجي نشوف إيش الفحصات + +92 +00:07:08,000 --> 00:07:11,580 +اللي بتنعمل للـ Von Willebrand Disease أول إيش هي + +93 +00:07:11,580 --> 00:07:16,310 +الـ Von Willebrand Disease اللي قد يكون فيه اختلاف + +94 +00:07:16,310 --> 00:07:19,690 +كمي وقد يكون qualitative يعني قد يكون quantitative + +95 +00:07:19,690 --> 00:07:23,710 +deficiency أو qualitative deficiency هو صحيح تلت + +96 +00:07:23,710 --> 00:07:27,670 +أنواع نوعه type 1 بيكون في عندنا quantitative + +97 +00:07:27,670 --> 00:07:30,510 +deficiency لكن مش completely يعني فيه partial + +98 +00:07:30,510 --> 00:07:34,530 +deficiency type 2 qualitative deficiency يعني أنه + +99 +00:07:34,530 --> 00:07:37,930 +الـantigen موجود أو الـvolume brand factor موجود + +100 +00:07:37,930 --> 00:07:43,110 +لكن ما بيشتغلش بالشكل الجيد الصحيح Type 3 Totally + +101 +00:07:43,110 --> 00:07:47,970 +Quantitative Deficiency أنه هو نفسه مش موجود في + +102 +00:07:47,970 --> 00:07:52,150 +مشكلة في تصنيعه نشوف إيش الفحصات اللي ممكن تنعمل + +103 +00:07:52,150 --> 00:07:55,750 +في فحصات بتبحث عنه كـ Antigen يعني هل هو موجود أو + +104 +00:07:55,750 --> 00:08:00,590 +مش موجود بغض النظر عن وظيفة في عندنا فحصات بتشوف + +105 +00:08:00,590 --> 00:08:04,530 +الـ Activity في عندنا الـ Multimarket Analysis أول + +106 +00:08:04,530 --> 00:08:08,610 +إشي الـ Vanwill Brand Antigen أكيد هو هيكون موجود + +107 +00:08:09,330 --> 00:08:13,150 +في الحالة الأولى لكن فيه deficiency الحالة الثانية + +108 +00:08:13,150 --> 00:08:15,850 +هيكون normal ليش؟ لأن ما فيش عندي مشكلة في الـ + +109 +00:08:15,850 --> 00:08:18,190 +Antigen قى Antigen لكن عندي مشكلة في الوظيفة + +110 +00:08:18,190 --> 00:08:21,930 +الحالة الثالثة هيكون فيه severe deficiency ليش؟ + +111 +00:08:21,930 --> 00:08:25,920 +لأن في عندي total quantitative deficiency طيب، نيجي + +112 +00:08:25,920 --> 00:08:29,780 +للـ Activity الـ Activity الحالة الأولى هيكون فيه + +113 +00:08:29,780 --> 00:08:32,500 +نقص في الـ Activity الحالة الثانية نقص في الـ + +114 +00:08:32,500 --> 00:08:34,840 +Activity لأنه فعليًا المشكلة عندنا مش في الـ + +115 +00:08:34,840 --> 00:08:37,820 +Antigen في الثانية في type 2 المشكلة عندنا في الـ + +116 +00:08:37,820 --> 00:08:41,960 +Activity زي ما حكينا الحالة الثالثة تقريبًا هيكون + +117 +00:08:41,960 --> 00:08:46,500 +الـ Activity قليلة جدًا لأن ال factor أصلاً مش موجود + +118 +00:08:46,500 --> 00:08:50,660 +نيجي لـ Multimer Analysis الـ Multimer Analysis + +119 +00:08:50,660 --> 00:08:54,040 +يعني هذه بتدل على إنه هل فعلاً تكون بالشكل الصحيح + +120 +00:08:54,040 --> 00:08:58,840 +وكون الـ Polymers اللي إحنا عارفينها إحنا حكينا + +121 +00:08:58,840 --> 00:09:02,820 +إنه بتكون كمونمر وبعدين بيستكون الملتمر الحالتين + +122 +00:09:02,820 --> 00:09:06,820 +الأولى ما فيش فيه مشكلة يعني هيكون الملتمر موجود + +123 +00:09:06,820 --> 00:09:10,960 +وما فيش فيه مشكلة في type 1 وtype 2 بينما في type 3 + +124 +00:09:10,960 --> 00:09:15,560 +هيكون absent لأنه أصلاً الـVar والـBrand فاكتر طيب + +125 +00:09:15,560 --> 00:09:22,410 +نيجي للـVitamin K deficiency الـVitamin K طبعًا الـ + +126 +00:09:22,410 --> 00:09:24,970 +Vitamin K بيجينا من الـ Green Vegetables بعدين + +127 +00:09:24,970 --> 00:09:28,350 +بيصير له synthesis عن طريق الـ Intestinal Flora + +128 +00:09:28,350 --> 00:09:34,070 +مطلوب الـ Vitamin K لتصنيع اللي هو factor 2 و7 و9 + +129 +00:09:34,070 --> 00:09:39,410 +و10 ومطلوب برضه لبروتين C وبروتين S إيش أسباب الـ + +130 +00:09:39,410 --> 00:09:43,570 +deficiency؟ قد يكون Malnutrition أو Biliary + +131 +00:09:43,570 --> 00:09:47,590 +Obstruction أو Malabsorption أو بعض الـ Antibiotic + +132 +00:09:47,590 --> 00:09:54,230 +Therapy علاجه ممكن ينعطى Vitamin K أو ينعطى Fresh + +133 +00:09:54,230 --> 00:10:01,630 +Frozen Plasma الآن + +134 +00:10:01,630 --> 00:10:06,170 +نيجي للـ Disseminated Intravascular Coagulation + +135 +00:10:06,170 --> 00:10:10,270 +طبعا هذا يعتبر من الحالات الخطيرة والصعبة في أمراض + +136 +00:10:10,270 --> 00:10:14,830 +الـ Hemostasis بينتج عن activation of both + +137 +00:10:14,830 --> 00:10:18,810 +coagulation and fibrinolysis من الحالات اللي ممكن + +138 +00:10:18,810 --> 00:10:25,170 +تعملها triggering زي حالات sepsis حالات لـ trauma زي + +139 +00:10:25,170 --> 00:10:28,470 +الـ head injury و الـ fat embolism حالات الـ + +140 +00:10:28,470 --> 00:10:32,170 +malignancy obstetrical complications اللي هي بتصير + +141 +00:10:32,170 --> 00:10:36,510 +مضاعفات اللي ممكن تصير في الحمل أو عند الولادة زي + +142 +00:10:36,510 --> 00:10:40,690 +حالات الـ amniotic fluid embolism زي حالات الـ + +143 +00:10:40,690 --> 00:10:45,650 +Abruptio placenta اللي هي انفصال المشيمة حالات الـ + +144 +00:10:45,650 --> 00:10:51,410 +vascular disorders Reaction to toxins عادة يحصل عند + +145 +00:10:51,410 --> 00:10:55,650 +لدغات الأفاعي والعقارب Snake venom أو بعض الـ drugs + +146 +00:10:55,650 --> 00:10:58,890 +بعض الـ immunological disorders زي الـ severe + +147 +00:10:58,890 --> 00:11:02,350 +allergic reaction أو الـ Transplant rejection كل + +148 +00:11:02,350 --> 00:11:07,190 +هذه حالات ممكن تعمل Triggering الـ Disseminated + +149 +00:11:07,190 --> 00:11:11,090 +Intravascular Coagulation Mechanism طبعاً حيصير + +150 +00:11:11,090 --> 00:11:14,610 +Systemic Activation of Coagulation حالات لما بيصير + +151 +00:11:14,610 --> 00:11:18,450 +Activation للـ Coagulation هيبدأ يتكون الفيبرين + +152 +00:11:18,450 --> 00:11:22,290 +الفيبرين هيبدأ يترسب Intravascular هيترسب بداخل + +153 +00:11:22,290 --> 00:11:25,970 +الـ blood vessels هذا رح يؤدي إلى انسداد بعض الـ + +154 +00:11:25,970 --> 00:11:30,970 +blood vessels الصغيرة و الحجمها متوسط و هيؤدي إلى + +155 +00:11:30,970 --> 00:11:34,130 +organ failure يعني لما يصير تسليط لـ blood vessel + +156 +00:11:34,130 --> 00:11:38,010 +بغض أورجان معين هذا الـ organ رح يصير فيه failure + +157 +00:11:38,010 --> 00:11:41,490 +شغلة تانية هيصير Depletion of platelets and + +158 +00:11:41,490 --> 00:11:45,060 +coagulation factor لأنه هيصير استهلاك لإلهم وهذا رح + +159 +00:11:45,060 --> 00:11:50,800 +يؤدي إلى bleeding هنا + +160 +00:11:50,800 --> 00:11:55,120 +برضه بيوضح الكلام بشكل أفضل ال pathogenesis of DIC + +161 +00:11:55,120 --> 00:11:59,640 +طبعا بيصير release لبعض الأشياء اللي بتحفز ال + +162 +00:11:59,640 --> 00:12:02,720 +coagulation اللي هي thromboplastic material في ال + +163 +00:12:02,720 --> 00:12:06,520 +circulation للأسباب اللي حكيناها قبلها فبتتنشط + +164 +00:12:06,520 --> 00:12:10,220 +عملية ال coagulation ال coagulation هيحول لثرمبين + +165 +00:12:10,220 --> 00:12:13,500 +فيها في النهاية الفيبرينوجين إلى فيبرين طبعا طالما + +166 +00:12:13,500 --> 00:12:17,820 +اتكون الـ Fibrin هيتنشط عملية الـ Fibrinolysis عن + +167 +00:12:17,820 --> 00:12:21,960 +طريق طبعا البلازمينوجين بتحول لبلازمين أو بيبدأ + +168 +00:12:21,960 --> 00:12:25,820 +يعمل degradation للـ Fibrin طبعا هذا هيقدي إلى + +169 +00:12:25,820 --> 00:12:30,040 +زيادة برضه الـ D-dimer والـ Fibrin degradation + +170 +00:12:30,040 --> 00:12:34,340 +products هنشوف إيش هيصير، هيصير استهلاك للـ + +171 +00:12:34,340 --> 00:12:39,020 +coagulation factors زي هنلاحظ في ارتفاع في الـ PTT + +172 +00:12:40,470 --> 00:12:43,590 +في الـ thrombin time هذا الـ thrombin time هو بشيط + +173 +00:12:43,590 --> 00:12:47,010 +على الـ fibrinogen ارتفاعه بيدل على أن الـ + +174 +00:12:47,010 --> 00:12:51,650 +fibrinogen منخفض الـ fibrinogen هنلاقيه لا هنلاقي + +175 +00:12:51,650 --> 00:12:56,630 +البلازمين ارتفع و قد إلى ارتفاع الـ fibrin + +176 +00:12:56,630 --> 00:13:00,590 +degradation of products Intravascular clot تكون + +177 +00:13:00,590 --> 00:13:04,010 +الـ clots في الـ blood vessels إيش هتعمل؟ هتنقص + +178 +00:13:04,010 --> 00:13:08,050 +البلاتلتز هتعمل عندك schistocyte من الحاجات المميزة + +179 +00:13:08,050 --> 00:13:13,230 +للـ DIC وجود طيب نيجي للـ platelet disorders + +180 +00:13:13,230 --> 00:13:16,450 +الـ platelet disorders قد تكون quantitative أو + +181 +00:13:16,450 --> 00:13:20,830 +qualitative الـ quantitative قد تكون بسبب abnormal + +182 +00:13:20,830 --> 00:13:25,820 +distribution يعني على سبيل المثال في مكان بقول + +183 +00:13:25,820 --> 00:13:29,980 +نفترض مثلا فيه Hepatosplenomegaly لو كان في حالة + +184 +00:13:29,980 --> 00:13:32,340 +Hepatosplenomegaly هتلاقي فيه تجمع كبير + +185 +00:13:32,340 --> 00:13:35,980 +للـ platelets في الـ spleen وفي الـ liver فهذا هيؤدي + +186 +00:13:35,980 --> 00:13:39,460 +إلى نقصها في الـ circulation فهذا مقصود بمعنى + +187 +00:13:39,460 --> 00:13:44,080 +الـ abnormal distribution dilution effect decreased + +188 +00:13:44,080 --> 00:13:47,260 +production increased destruction يعني هذه الحاجات + +189 +00:13:47,260 --> 00:13:51,050 +اللي ممكن تؤدي إلى نقص للـ platelets Qualitative + +190 +00:13:51,050 --> 00:13:55,650 +disorders قد تكون inherited وهي نادرة يعني في أنها + +191 +00:13:55,650 --> 00:13:58,990 +مشكلة في وظيفة الـ platelets نفسها وقد تكون + +192 +00:13:58,990 --> 00:14:02,830 +acquired بسبب medications أو chronic renal failure + +193 +00:14:02,830 --> 00:14:06,770 +أو cardiopulmonary bypass عارفين إيش يعني cardio + +194 +00:14:06,770 --> 00:14:10,030 +pulmonary bypass اللي هو لما بيعملوا عمليات القلب + +195 +00:14:10,030 --> 00:14:13,850 +مفتوح بيحطوا جهاز يقوم بدور القلب والرئتين خلال + +196 +00:14:13,850 --> 00:14:14,930 +إجراء العملية + +197 +00:14:18,960 --> 00:14:23,100 +خلّينا الآن نبدأ نشوف كيف بدنا نعمل lab evaluation + +198 +00:14:23,100 --> 00:14:28,540 +لل bleeding disorders أول حاجة الـ CBC و البلد + +199 +00:14:28,540 --> 00:14:31,920 +السمير طبعا الـ CBC و البلد السمير هيفيدوني في + +200 +00:14:31,920 --> 00:14:35,360 +موضوع البلاتلت يعني بشوف من خلالهم البلاتلت count + +201 +00:14:35,360 --> 00:14:40,760 +إذا كان فيه thrombocytopenia بشوف من خلالهم زي + +202 +00:14:40,760 --> 00:14:44,220 +حالات الـ ITP اللي هي thrombocytopenic purpura + +203 +00:14:44,220 --> 00:14:47,420 +إذا كان فيه مثلا schistocyte ممكن يدل على إنه فيه + +204 +00:14:47,420 --> 00:14:51,120 +DIC and so on فبالتالي الـ Blood Smear بنشوف من + +205 +00:14:51,120 --> 00:14:54,020 +خلالها Platelet Count RBCs and Platelet + +206 +00:14:54,020 --> 00:14:57,380 +Morphology يعني بتفيدني بس في الموضوع الـ Platelet + +207 +00:14:57,380 --> 00:15:03,100 +إلى حد ما يعني في الـ DIC بشوف Shistocyte طيب الـ + +208 +00:15:03,100 --> 00:15:06,140 +Coagulation Profile فحوصات الـ Coagulation اللي + +209 +00:15:06,140 --> 00:15:09,960 +هنعملها الـ Prothrombin Time للـ Extrinsic Pathway + +210 +00:15:09,960 --> 00:15:14,380 +PTT للـ Intrinsic Pathway Coagulation Factor Assay + +211 +00:15:14,380 --> 00:15:17,000 +عشان نعرف بعض الـ Factors إذا كان فيها Deficiency + +212 +00:15:17,640 --> 00:15:21,780 +الـ Mixing Study 50 إلى 50 هنشوف إذا كان فيه + +213 +00:15:21,780 --> 00:15:25,880 +Inhibitors الـ Fibrinogen Assay عشان نشوف الـ + +214 +00:15:25,880 --> 00:15:28,740 +Level للـ Fibrinogen الـ Thrombin Time طبعاً بدل + +215 +00:15:28,740 --> 00:15:33,340 +على إذا كان في عندي مشكلة في الـ Fibrinogen الـ + +216 +00:15:33,340 --> 00:15:36,060 +Fibrinogen Defect قد يكون qualitative أو + +217 +00:15:36,060 --> 00:15:39,860 +quantitative Fibrin degradation products or D + +218 +00:15:39,860 --> 00:15:43,600 +-dimer كل هذه الأشياء ممكن نعملها راح ناخدها بشيء + +219 +00:15:43,600 --> 00:15:46,390 +من التفصيل الـ Platelet Function من ضمن الأشياء + +220 +00:15:46,390 --> 00:15:48,770 +اللي ممكن تنعملها وظيفة الـ Platelet الـ Funnel + +221 +00:15:48,770 --> 00:15:52,190 +Bleeding Time Factor، Bleeding Time، Platelet Function + +222 +00:15:52,190 --> 00:15:59,950 +Analyzer، Platelet الآن بدنا ناخد مع بعض مرور سريع + +223 +00:15:59,950 --> 00:16:04,290 +على فحوصات الـ Hemostasis وكيف أنا بستخدمها في ال + +224 +00:16:04,290 --> 00:16:09,750 +diagnosis للحالات المرضية الآن لو أجى مريض عنده أو + +225 +00:16:09,750 --> 00:16:14,650 +بيعاني من bleeding هذا المريض أكيد راح يطلبله + +226 +00:16:14,650 --> 00:16:18,890 +الدكتور CBC بعد السؤول ومع الـ CBC حيطلبله الـ + +227 +00:16:18,890 --> 00:16:22,230 +Coagulation Profile إيش حيطلبله بالظبط؟ حيطلبله + +228 +00:16:22,230 --> 00:16:26,290 +غالبا PT و PTT أول حاجة زي ما اتفقنا إن الـ PTT + +229 +00:16:26,290 --> 00:16:29,510 +بيشيك على الـ Intrinsic Pathway و الـ Common + +230 +00:16:29,510 --> 00:16:33,430 +Pathway لعند الفيبرينجين و الـ Prothrombin Time + +231 +00:16:33,430 --> 00:16:36,550 +حيشيك على الـ Extrinsic Pathway و الـ Common Pathway + +232 +00:16:36,550 --> 00:16:39,570 +برضه لعند الفيبرينجين يعني هدول ما حيشيكوا على + +233 +00:16:39,570 --> 00:16:43,700 +الفيبرينجين عندي فحص ثاني بشيك على الـ fibrinogen + +234 +00:16:43,700 --> 00:16:47,120 +اللي هو الـ thrombin time إذا كان الـ thrombin + +235 +00:16:47,120 --> 00:16:50,360 +time prolonged معنى الكلام أن الـ fibrinogen فيه + +236 +00:16:50,360 --> 00:16:54,120 +deficiency فبنروح بنعمل assay للـ fibrinogen و + +237 +00:16:54,120 --> 00:16:58,180 +بنحدد قيمته تمام؟ إذا هدول تقريبا التلات فحصات + +238 +00:16:58,180 --> 00:17:02,600 +الرئيسية في الـ .. في الـ .. في الـ coagulation + +239 +00:17:02,600 --> 00:17:07,950 +profile هنا بناقش معانا بعض الـ Technical Errors + +240 +00:17:07,950 --> 00:17:10,750 +يعني احنا أخدناها بالتفصيل في مادة النزف العملي + +241 +00:17:10,750 --> 00:17:15,410 +اللي هو موضوع الـ Sodium Citrate اللي أنا استخدمته + +242 +00:17:15,410 --> 00:17:17,350 +طبعا احنا بنستخدم الـ Sodium Citrate كـ + +243 +00:17:17,350 --> 00:17:20,330 +Anticoagulant هل الـ Sodium Citrate كانت كميته + +244 +00:17:20,330 --> 00:17:23,830 +متناسبة مع كمية الـ Blood لأنه لو ماكانش فيه تناسب + +245 +00:17:23,830 --> 00:17:27,330 +سواء بزيادة أو بنقصان هيعمل prolongation للـ Time + +246 +00:17:27,330 --> 00:17:31,930 +مثلا صار تسرب للـ Sodium Citrate من القبوبة خلال + +247 +00:17:31,930 --> 00:17:36,510 +عملية السحب لو صار عندي مشاكل أنا سحبت ببطء لو عملت + +248 +00:17:36,510 --> 00:17:39,910 +Label غلط، لو عملت checking مش بشكل صحيح، لو صار + +249 +00:17:39,910 --> 00:17:42,970 +Heparin contamination للعينة، لو كنت أنا بسحب من + +250 +00:17:42,970 --> 00:17:47,590 +Travenous line، ممكن كل هذه الأشياء تؤثر على + +251 +00:17:47,590 --> 00:17:52,390 +نتائج بتعتمد على أسباب تانية، biological factors، زي + +252 +00:17:52,390 --> 00:17:54,690 +مثلا الـ Hematocrit، إذا كنتوا فاكرين إذا كان + +253 +00:17:54,690 --> 00:17:57,430 +الـ Hematocrit مرتفع كتير أو منخفض كتير، لازم أنا + +254 +00:17:57,430 --> 00:18:01,530 +أعمله correction عشان أحسب كمية الصدر، كمسترات + +255 +00:18:01,530 --> 00:18:06,150 +المناسبة في كل حالة، لو كان فيه ليبيميا مثلا في + +256 +00:18:06,150 --> 00:18:09,210 +العينة أو ارتفاع في الـ bilirubin كلها هذه أشياء + +257 +00:18:09,210 --> 00:18:14,690 +بتأثر على النتيجة، بعندي أشياء برضه أخرى زي لو أنا + +258 +00:18:14,690 --> 00:18:18,550 +طولت على العينة، في عندي labile factors حتتأثر لو + +259 +00:18:18,550 --> 00:18:21,150 +طولت ال incubation في ال 37 برضه هيأثر على ال + +260 +00:18:21,150 --> 00:18:25,590 +labile factors، لو أنا خلال ما فرزتش العينة، لو أنا + +261 +00:18:25,590 --> 00:18:29,330 +بدي افرزها وجيت فرزتها ودوبتها مش مش مش مش مش مش + +262 +00:18:29,330 --> 00:18:30,310 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +263 +00:18:30,310 --> 00:18:30,330 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +264 +00:18:30,530 --> 00:18:35,210 +فترضوا أنه أنا عملت فحوصات الـ coagulation لواحد + +265 +00:18:35,210 --> 00:18:39,030 +بنزف وطلع عنده كل شي، طلعت البلاستيكس طبيعية وطلع + +266 +00:18:39,030 --> 00:18:44,910 +الـ BT و الـ BTT normal، بروح بعمل فحوصات عشان + +267 +00:18:44,910 --> 00:18:50,750 +تشوفلي factor 13 و factor 2 اللي هو الـ factor + +268 +00:18:50,750 --> 00:18:53,310 +عفواً one اللي هو الـ fibrinogen، طبعا إذا كنتوا + +269 +00:18:53,310 --> 00:18:56,970 +فاكرين قلتلكم الـ BT و الـ BTT بشيكولي على الـ + +270 +00:18:56,970 --> 00:19:00,680 +coagulation cascade لعند الفيبرنجين، الـ Fibrinogen + +271 +00:19:00,680 --> 00:19:04,460 +وFactor 13» لهم فحوصات خاصة فيهم، الـ Fibrinogen + +272 +00:19:04,460 --> 00:19:07,940 +باختبره من خلال الـ Thrombin Time، Factor 13» من + +273 +00:19:07,940 --> 00:19:11,520 +خلال فحص اللي هو الـ Urea Solubility، الآن لو كان + +274 +00:19:11,520 --> 00:19:16,240 +فيه Bleeding والـ BT وBTT Normal، بروح بعمل الـ Urea + +275 +00:19:16,240 --> 00:19:20,340 +Solubility بشوف إذا كان Abnormal، احتمال تبقى + +276 +00:19:20,340 --> 00:19:24,300 +Deficiency بFactor 13» طيب إذا كان Normal، إذا كان + +277 +00:19:24,300 --> 00:19:28,670 +Normal فيه احتمال، الاحتمال الأول أن يكون mild + +278 +00:19:28,670 --> 00:19:31,330 +factor deficiency، يعني في factor deficiency لكن ما + +279 +00:19:31,330 --> 00:19:37,750 +ظهرت في الـBT وBTT، ليش؟ لأن الـBT وBTT 50% من ال + +280 +00:19:37,750 --> 00:19:41,800 +factor activity هتعطيني normal BT وBTT، يعني لو كان + +281 +00:19:41,800 --> 00:19:44,640 +الـFactor نازل لمُنصّف الـActivity بتاعته هيعطيني + +282 +00:19:44,640 --> 00:19:48,120 +Normal Pt وPtT، طبعاً هذا بيقلل من الـSensitivity + +283 +00:19:48,120 --> 00:19:53,340 +تبعتهم، عشان هيك احتمال يبقى فيه Deficiency لكن ما + +284 +00:19:53,340 --> 00:19:57,680 +بيّنت وما ظهر معايا Abnormality في الـPt وPtT، ممكن + +285 +00:19:57,680 --> 00:20:01,840 +يبقى فيه خلل في الـFibrinolysis، ممكن بسبب + +286 +00:20:01,840 --> 00:20:05,340 +elevation في الـFibrin degradation Products، ممكن + +287 +00:20:05,340 --> 00:20:08,980 +Monoclonal Gamma Pathy، ممكن Platelet Disorder، ممكن + +288 +00:20:08,980 --> 00:20:13,580 +Vascular Disorder، يعني في مشاكل أخرى غير الـ + +289 +00:20:13,580 --> 00:20:19,140 +Factor Deficiency، طيب نيجي نفترض أنه احنا عملنا + +290 +00:20:19,140 --> 00:20:22,540 +الـ BT و الـ BTT بغض النظر مين فيهم طلع Normal + +291 +00:20:22,540 --> 00:20:25,420 +ومين فيهم Abnormal، طلع فيهم واحد Normal وواحد + +292 +00:20:25,420 --> 00:20:29,740 +Abnormal، السيناريو المتبع أنه نشوف الـ Abnormality + +293 +00:20:29,740 --> 00:20:32,640 +هذه إيش سببها؟ طبعا الـ Abnormality قد يكون سببها + +294 +00:20:32,640 --> 00:20:37,530 +Factor Deficiency أو قد يكون سببها «factor + +295 +00:20:37,530 --> 00:20:41,730 +inhibitors»، فأنا بدي أعمل الـ «mixing study» عشان + +296 +00:20:41,730 --> 00:20:45,550 +أعرف إذا كانت «factor deficiency» ولا «inhibitors» + +297 +00:20:45,550 --> 00:20:49,230 +طيب، كيف بعمل الـ «mixing study»؟ الـ «sample» + +298 +00:20:49,230 --> 00:20:53,770 +اللي بدي أستخدمها باخد نصها، خليني أفترض إني بدي + +299 +00:20:53,770 --> 00:20:58,290 +أخد 100 ميكروليتر، الـ 100 ميكروليتر هدول باخد 50 + +300 +00:20:58,290 --> 00:21:02,710 +منهم من الـ «sample» زائد 50 من «normal control» + +301 +00:21:02,710 --> 00:21:06,180 +مافيش فيه deficiency، إيش الهدف من عملية الـ Mix + +302 +00:21:06,180 --> 00:21:10,700 +هادى؟ هلاقيت لو كان فيه فعلًا Factor Deficiency + +303 +00:21:10,700 --> 00:21:13,740 +خمسين Micron اللي أخدتهم من الـ Normal Control + +304 +00:21:13,740 --> 00:21:17,320 +هتعوض الـ Deficiency هادى وتعطيني Normal Result + +305 +00:21:17,320 --> 00:21:21,900 +لكن لو كان فيه Inhibitor، الخمسين Micron اللي + +306 +00:21:21,900 --> 00:21:24,700 +أضفتهم من الـ Normal Control برضه هيصير لهم + +307 +00:21:24,700 --> 00:21:29,280 +Inhibition فبالتالي مش هيصير تعويض للخلل وبالتالي + +308 +00:21:29,280 --> 00:21:34,470 +النتيجة هتظل Abnormal، تمام؟ الـ Mixing Studyبعمل + +309 +00:21:34,470 --> 00:21:38,430 +mix للعينة، نصها من العينة اللي أنا بشتغل عليها + +310 +00:21:38,430 --> 00:21:42,230 +اللي طلعت abnormal ونصها من عينة normal control + +311 +00:21:42,230 --> 00:21:45,930 +هلأ إذا صار correction وتصحيح للنتيجة، معنى الكلام + +312 +00:21:45,930 --> 00:21:49,930 +إنه factor deficiency، إذا ما صارش correction معنى + +313 +00:21:49,930 --> 00:21:53,670 +الكلام إنه في عندي inhibitors هي اللي قدت لل + +314 +00:21:53,670 --> 00:21:58,150 +prolongation، تمام؟ إذا خلّيني أخد نموذج، في عندي + +315 +00:21:58,150 --> 00:22:03,380 +normal BT و abnormal BTT، abnormal BTT هذا بيدل على + +316 +00:22:03,380 --> 00:22:06,780 +إنه الخلل اللي جاي في الـ Intrinsic Pathway، طب + +317 +00:22:06,780 --> 00:22:10,440 +إحنا ليش استثنين الـ Common Pathway؟ لأن الـ BTT + +318 +00:22:10,440 --> 00:22:14,720 +Normal، لو كان في خلل في الـ Common Pathway هيبين + +319 +00:22:14,720 --> 00:22:17,600 +في الـ BTT، صح؟ لأن الـ Common Pathway مشترك بين + +320 +00:22:17,600 --> 00:22:22,380 +التنين، لذَن وجود Normal BTT و Normal BTT بقول إن في + +321 +00:22:22,380 --> 00:22:26,640 +عندي خلل في الـ Intrinsic Pathway، فبدي أعمل الـ + +322 +00:22:26,640 --> 00:22:31,120 +Mixing Study، فلقيت إذا ضل الفحص Abnormal إذا في + +323 +00:22:31,120 --> 00:22:33,900 +عندي Inhibitors للـ Factors تحت الـ Intrinsic + +324 +00:22:33,900 --> 00:22:38,320 +Pathway، قد تكون Specific Inhibitors زي Factor 8 أو + +325 +00:22:38,320 --> 00:22:42,120 +9 أو 11 Inhibitors أو non-Specific Inhibitors زي + +326 +00:22:42,120 --> 00:22:44,060 +الـ Antilobus Anticoagulant اللي هي الـ + +327 +00:22:44,060 --> 00:22:48,920 +Antiphospholipid Antibody، لكن الاحتمال التاني إنه + +328 +00:22:48,920 --> 00:22:53,630 +يصير Correction يعني لما أعمل Mixing Study، الـ + +329 +00:22:53,630 --> 00:22:57,030 +Correction للنتيجة، معنى الكلام أنه فيه factor + +330 +00:22:57,030 --> 00:23:00,910 +deficiency، فبدي أشوف أي factor فيه deficiency أو + +331 +00:23:00,910 --> 00:23:04,230 +ممكن أعمل assay لل factor بالـ one stage assay إذا + +332 +00:23:04,230 --> 00:23:07,730 +كنتوا فاكرين الـ one stage assay بستخدمه عشان أحدد + +333 +00:23:07,730 --> 00:23:12,030 +ال activity لكل factor على حدة، ممكن تكون المشكلة + +334 +00:23:12,030 --> 00:23:15,910 +جاية من multiple factor deficiencies، نفس الكلام + +335 +00:23:15,910 --> 00:23:19,850 +هنا يكرر أنه طلع عند الأبناء الـ BT، الـ BT + +336 +00:23:19,850 --> 00:23:25,150 +abnormal والـ BTT normal، هلقيت هنا بقول إنه المشكلة + +337 +00:23:25,150 --> 00:23:28,750 +في الـextrinsic pathway، يعني الـextrinsic pathway + +338 +00:23:28,750 --> 00:23:32,090 +normal والcommon pathway normal، بس المشكلة وين + +339 +00:23:32,090 --> 00:23:36,750 +تركزت في الـextrinsic pathway، بدي أعمل الـmixing + +340 +00:23:36,750 --> 00:23:40,930 +study، الآن إذا كانت ال mixing study abnormal، ممكن + +341 +00:23:40,930 --> 00:23:43,390 +يكون specific factor inhibitor، هيكون ال factor + +342 +00:23:43,390 --> 00:23:46,890 +الوحيد اللي بحكي عنه هنا factor 7، وهدي عادة rare + +343 +00:23:46,890 --> 00:23:50,630 +لما يكون فيه inhibitor ل factor 7 أو non-specific + +344 +00:23:50,630 --> 00:23:54,470 +inhibitor زي الـ antiphospholipids، إذا صار + +345 +00:23:54,470 --> 00:23:58,900 +correction بعد ال mixing study، بدي أعمل deficiency + +346 +00:23:58,900 --> 00:24:02,720 +يعني أعمل factor assay عشان أشوف إذا كان فيه factor + +347 +00:24:02,720 --> 00:24:06,960 +deficiency زي أشوف isolated factor deficiency وعلى + +348 +00:24:06,960 --> 00:24:11,300 +فكرة factor 7 نادر لما بينقص لحاله، عادة بتكون جاية + +349 +00:24:11,300 --> 00:24:14,300 +من multiple factor deficiency، وال multiple factor + +350 +00:24:14,300 --> 00:24:17,960 +deficiency هذه بتكون جاية من شغلة أثرت على vitamin + +351 +00:24:17,960 --> 00:24:22,500 +K، لأن factor 7 من ضمن 2 و7 و9 و10 اللي هم بيصنعهم + +352 +00:24:22,500 --> 00:24:27,520 +vitamin K، إذا كان فيه vitamin K deficiency هيأثر على + +353 +00:24:27,520 --> 00:24:31,380 +مجموعة factors من ضمنهم factors سبعة، تمام؟ زي + +354 +00:24:31,380 --> 00:24:34,540 +حالات liver disease والـ vitamin K deficiency وحالات + +355 +00:24:34,540 --> 00:24:41,200 +جرعات الوافرين والـDIC، طيب، + +356 +00:24:41,200 --> 00:24:45,860 +نيجي إن اتنين كانوا abnormal، الـBT و الـBTT كانوا + +357 +00:24:45,860 --> 00:24:49,260 +abnormal، إيش الاحتمالات؟ طبعاً برضه بدنا نعمل + +358 +00:24:49,260 --> 00:24:55,030 +mixing study، بدنا نعمل mixing study نشوف، الآن إذا + +359 +00:24:55,030 --> 00:24:58,670 +صار يعني ما صارش correction أو كانت النتيجة لازلة + +360 +00:24:58,670 --> 00:25:01,950 +abnormal، معنى الكلام إنه فيه factor inhibitors + +361 +00:25:01,950 --> 00:25:06,370 +ممكن تكون specific factor inhibitors زي factor 5 و + +362 +00:25:06,370 --> 00:25:13,630 +10 و factor 2 و factor 2، ممكن تكون fibrinogen، وهدي + +363 +00:25:13,630 --> 00:25:17,770 +أقل شيوعاً، non-specific inhibitors هي الشائعة اللي + +364 +00:25:17,770 --> 00:25:21,610 +هي زي lobus anticoagulant، الآن لو صار correction + +365 +00:25:21,610 --> 00:25:24,450 +هيكون factor deficiency، طب ال factor deficiency + +366 +00:25:24,450 --> 00:25:29,690 +هنا في أي منطقة هتكون؟ غالباً هتكون في ال common + +367 +00:25:29,690 --> 00:25:33,130 +pathway، لأن الاتنين مع بعض اتأثروا، يعني إلا يكون + +368 +00:25:33,130 --> 00:25:36,630 +factors ال common pathway انضمنت أو بعض ال factors + +369 +00:25:36,630 --> 00:25:41,290 +من ال common pathway تأثرت في هذه ال deficiency of + +370 +00:25:41,290 --> 00:25:44,230 +four-factor deficiency زي isolated deficiency in + +371 +00:25:44,230 --> 00:25:46,950 +common pathway زي factor خمسة، factor عشرة + +372 +00:25:46,950 --> 00:25:50,670 +البروثرومبين، فيبرنجل أو multiple-factor deficiency + +373 +00:25:50,670 --> 00:25:54,530 +هذه عادة شائعة زي حالات المشاكل اللي قلنا عنها + +374 +00:25:54,530 --> 00:25:57,870 +تولي بتأثير على الـVitamin K dependent factors + +375 +00:26:05,020 --> 00:26:08,440 +في عندنا ملخص للـ Coagulation Factor Deficiencies + +376 +00:26:08,440 --> 00:26:11,440 +الـ Coagulation Factor Deficiencies في عندي six + +377 +00:26:11,440 --> 00:26:15,300 +linked الـ six linked طبعاً بيكون فيها هيموفيليا A + +378 +00:26:15,300 --> 00:26:18,460 +و هيموفيليا B هيموفيليا A و هيموفيليا B اللتان + +379 +00:26:18,460 --> 00:26:21,720 +بيؤثران على الـ BTT لأنهم Intrinsic Factors الـ BT + +380 +00:26:21,720 --> 00:26:25,300 +بيكون Normal الـ Autosomal Recessive Autosomal + +381 +00:26:25,300 --> 00:26:28,520 +Recessive زي ال factors اللي ممكن يصير فيها + +382 +00:26:28,520 --> 00:26:35,470 +Deficiencies زي Factor 2 و 5 و 7 و 10 و 11 هذه + +383 +00:26:35,470 --> 00:26:38,610 +ممكن تؤثر على التانين لأن في منهم بيجيوا بالـ + +384 +00:26:38,610 --> 00:26:43,110 +Common Pathway Factor 13 Deficiency is associated + +385 +00:26:43,110 --> 00:26:47,350 +with bleeding and impaired wound healing سيكون + +386 +00:26:47,350 --> 00:26:50,670 +الـBT وBTT Normal زي ما قلنا الـClot Solubility + +387 +00:26:50,670 --> 00:26:55,770 +Test أو الـUrea Solubility بيكون Abnormal Factor 2 + +388 +00:26:55,770 --> 00:26:58,710 +Brachial Kininogen High Molecular Weight Deficiency + +389 +00:26:58,710 --> 00:27:01,970 +don't cause bleeding هذه الـFactors لو صار بالفاكتور + +390 +00:27:01,970 --> 00:27:04,970 +عفوا مش اثنين فاكتور اثنا عشر برايكاليكرين high + +391 +00:27:04,970 --> 00:27:08,050 +molecular weight kynogen هذه الفاكتور لو صار فيها + +392 +00:27:08,050 --> 00:27:15,510 +deficiency عادة ما بتسببش bleeding نأتي + +393 +00:27:15,510 --> 00:27:19,590 +للثرومبين تايم الثرومبين تايم هذا فحص قلنا يشيك + +394 +00:27:19,590 --> 00:27:23,550 +على الفيبرينجين هل الفيبرينجين المستوى بتاعه + +395 +00:27:23,550 --> 00:27:27,780 +normal ولا لأ كيف فكرته؟ فكرته بسيطة جدا أنا فيها + +396 +00:27:27,780 --> 00:27:31,060 +بعتمد على آخر خطوة من التفاعل اللي هو تحول الـ + +397 +00:27:31,060 --> 00:27:35,700 +Fibrinogen إلى Fibrin الـ Fibrinogen عشان يتحول لـ + +398 +00:27:35,700 --> 00:27:40,780 +Fibrin ماذا يحتاج؟ يحتاج Thrombin فأنا أضيف كمية كبيرة + +399 +00:27:40,780 --> 00:27:44,880 +من الـ Thrombin و أسمح للـ Fibrinogen إنه يتحول + +400 +00:27:44,880 --> 00:27:48,940 +إلى Fibrin فلقيته أنا بغض النظر ما هو موجود عندي + +401 +00:27:48,940 --> 00:27:53,080 +deficiency من ال factors في الـ cascade لا يهمني + +402 +00:27:53,080 --> 00:27:56,880 +لماذا؟ لأني وفّرت آخر حاجة وفّرت الحاجة المسؤولة + +403 +00:27:56,880 --> 00:28:00,580 +عن تحويل الـ Fibrinogen إلى Fibrin فإذا صار التحويل + +404 +00:28:00,580 --> 00:28:03,620 +بالشكل المناسب معنى الكلام إن الـ Fibrinogen ليس + +405 +00:28:03,620 --> 00:28:07,980 +فيه مشكلة لكن لو أنا وفّرت كل الظروف للـ fibrinogen + +406 +00:28:07,980 --> 00:28:11,820 +وضعت الثرومبين بكمية كافية ولم يتحول لـ fibrin + +407 +00:28:11,820 --> 00:28:14,880 +معنى الكلام أن الـ fibrinogen نفسه هو الذي فيه + +408 +00:28:14,880 --> 00:28:19,720 +مشكلة bypass factor 2 و factor 12 يعني أنا بغض + +409 +00:28:19,720 --> 00:28:25,700 +النظر يعني بغض النظر ما هي موجودة عندي factors ما بين + +410 +00:28:25,700 --> 00:28:28,860 +factor 12 و factor 2 هل هي فيها deficiency أو + +411 +00:28:28,860 --> 00:28:32,580 +ليس فيها deficiency أنا تجاوزتهم وحطيت كمية كبيرة + +412 +00:28:32,580 --> 00:28:37,090 +من الـ Fibrin عفوا من الـ Thrombin «Add thrombin + +413 +00:28:37,090 --> 00:28:40,870 +with patient sample» «measure time to clot» أضيف + +414 +00:28:40,870 --> 00:28:45,850 +الـ Thrombin و أشوف العينة هل صار لها clot ولا لأ + +415 +00:28:45,850 --> 00:28:48,130 +إذا كان الـ time normal إذا الـ fibrin و الـ + +416 +00:28:48,130 --> 00:28:50,170 +normal إذا لم يكن الـ time normal إذا فيه + +417 +00:28:50,170 --> 00:28:54,270 +deficiency في الـ fibrin في بعض المتغيرات في الفحص + +418 +00:28:54,270 --> 00:28:57,830 +تعود لطبيعة الفيس للـ Thrombin و أنا من أين جبتها + +419 +00:29:01,180 --> 00:29:03,580 +ما هي الأسباب التي تؤدي لـ prolongation للـ + +420 +00:29:03,580 --> 00:29:06,760 +thrombin time؟ إذا كان ال patient يأخذ هيبرين + +421 +00:29:06,760 --> 00:29:10,720 +ثيرابي لأن الهيبرين يعمل كمثبط للثرومبين فأنا لما + +422 +00:29:10,720 --> 00:29:14,600 +أضيف للثرومبين وفيه هيبرين سيؤدي ذلك بالتأكيد لـ prolongation + +423 +00:29:14,600 --> 00:29:18,560 +نقص الـ fibrinogen أو فيه فيبرينوجين لكنه غير فعال + +424 +00:29:18,560 --> 00:29:21,820 +dysfibrinogenemia elevated fibrin degradation + +425 +00:29:21,820 --> 00:29:27,880 +products or paraproteins thrombin inhibitors مثل + +426 +00:29:27,880 --> 00:29:31,480 +الهيرودين و الـ thrombin antibodies كلها هذه + +427 +00:29:31,480 --> 00:29:37,720 +الأشياء ممكن تعمل elongation نأتي + +428 +00:29:37,720 --> 00:29:42,420 +لموضوع الـ thrombocytopenia و جاء مريض أريد أن أشوف + +429 +00:29:42,420 --> 00:29:45,920 +إذا كان يعني عنده thrombocytopenia لديه نقص في الـ + +430 +00:29:45,920 --> 00:29:50,780 +platelets أريد أن آخذ ال history هل حصل عنده bleeding + +431 +00:29:50,780 --> 00:29:54,480 +مثلاً هل عنده أمراض أخرى مثل cancer مثل autoimmune + +432 +00:29:54,480 --> 00:29:59,140 +disease هل يأخذ أدوية معينة، يتعاطى كحول، يعاني + +433 +00:29:59,140 --> 00:30:03,400 +أو عنده risk factor للـHIV؟ هل في عنده family + +434 +00:30:03,400 --> 00:30:06,040 +history للـThrombocytopenia؟ لأعرف ما هو سببها + +435 +00:30:06,040 --> 00:30:11,640 +طيب، هل في مثلاً شكل ال bleeding أو ال spot بتاعة + +436 +00:30:11,640 --> 00:30:16,180 +البيتاكيا التي ظهرت، هل يعني أتوقع من خلالها إنه + +437 +00:30:16,180 --> 00:30:20,670 +في فعلاً platelet deficiency؟ طبعاً بعد ذلك يعني بدنا + +438 +00:30:20,670 --> 00:30:24,930 +نأخذ ال history بتاع المريض ال CPC سيظهر عندي عدد + +439 +00:30:24,930 --> 00:30:28,230 +البلاتلت أقوم بعمل peripheral blood smear لأرى شكل + +440 +00:30:28,230 --> 00:30:30,830 +البلاتلت أيضاً ال morphology تبعها مهم جداً لأنه + +441 +00:30:30,830 --> 00:30:34,750 +ممكن يكون عددها طبيعي لكنها غير فعالة أقوم بعمل + +442 +00:30:34,750 --> 00:30:38,750 +bleeding time أو bleeding أو blatlet aggregation + +443 +00:30:38,750 --> 00:30:45,150 +study هنا عندي رسم بياني يوضح عندي علاقة عدد + +444 +00:30:45,150 --> 00:30:48,690 +البلاتلت بالأعراض التي ممكن تظهر على المريض يعني + +445 +00:30:48,690 --> 00:30:54,050 +أقول لك أنه مثلاً هنا الـ Platelet count و هنا شدة + +446 +00:30:54,050 --> 00:30:57,090 +الأعراض يعني مثلاً Zero, no bleeding Number one, + +447 +00:30:57,230 --> 00:31:01,230 +minimal bleeding Spontaneous, self-limited ثلاثة, + +448 +00:31:01,290 --> 00:31:04,470 +spontaneous, requiring local treatment أربعة, + +449 +00:31:04,570 --> 00:31:08,030 +spontaneous, uncontrolled or poorly controlled بسبب + +450 +00:31:08,030 --> 00:31:10,810 +الـ deficiency في الـ Platelets فلقيته لو أتينا + +451 +00:31:10,810 --> 00:31:14,030 +مثلاً في الـ Range هذا قلنا إنه الـ Platelet + +452 +00:31:14,030 --> 00:31:20,620 +من 150 لغاية 450 ألف الـ Bladlet لو كانت من لغاية + +453 +00:31:20,620 --> 00:31:27,400 +تقريباً نقول 60 عادة ما يصير bleeding نبدأ عند + +454 +00:31:27,400 --> 00:31:31,680 +الخمسين يصير احتماليه minimal bleeding تمام؟ لو + +455 +00:31:31,680 --> 00:31:36,900 +وصلت عندها تقريباً من العشرين والثلاثين ممكن يكون + +456 +00:31:36,900 --> 00:31:41,280 +spontaneous self-limited bleeding لو نزلت عن عشرين + +457 +00:31:41,280 --> 00:31:46,920 +ممكن تزيد ال severity وتحتاج لـ treatment لو نقصت + +458 +00:31:46,920 --> 00:31:51,080 +عن عشرة سنلاحظ أنه سيصير عندنا «severe bleeding, + +459 +00:31:51,280 --> 00:31:54,180 +uncontrolled or poorly controlled» فبتتالي عدد + +460 +00:31:54,180 --> 00:31:58,440 +الصفائح يعني ليس مجرد ما تنزل الصفائح عن 150 سيبدأ + +461 +00:31:58,440 --> 00:32:01,340 +يصير bleeding ونحن نلاحظه يعني نحن نلاحظه لما + +462 +00:32:01,340 --> 00:32:04,140 +يكون فعلاً نزلت تقريباً عن 50 أو عند 40 + +463 +00:32:10,140 --> 00:32:14,160 +طيب هنا أقول لك أنه bleeding time and bleeding نحن + +464 +00:32:14,160 --> 00:32:17,120 +فيه فحص ل bleeding time هو فحص غير دقيق أبداً + +465 +00:32:17,120 --> 00:32:24,920 +نقوم به من خلاله نرى وضع ال platelets طبعاً خمسة إلى + +466 +00:32:24,920 --> 00:32:27,820 +عشرة في المئة من المرضى نقوم بعمل لهم يعطوني prolonged + +467 +00:32:27,820 --> 00:32:31,380 +bleeding time وعادة يكون ال prolongation نتيجة + +468 +00:32:31,380 --> 00:32:33,780 +بعض الأدوية التي ممكن يكون أخذها المريض مثل + +469 +00:32:33,780 --> 00:32:39,110 +الأسبرين أو غيره طبعاً يعني لو أنا لقيت ال bleeding + +470 +00:32:39,110 --> 00:32:43,350 +time عالي ليس شرط أنه هذا الشخص لو دخل عملية ممكن + +471 +00:32:43,350 --> 00:32:46,370 +ينزف لأنه أنتم تعرفون ال bleeding time لو كان + +472 +00:32:46,370 --> 00:32:49,530 +عالي يكون خلل في البلاتلت وخلل في البلاتلت يصير + +473 +00:32:49,530 --> 00:32:53,930 +نزيف بسيط عند بداية العملية وبنتي فبالتالي ليس فحص + +474 +00:32:53,930 --> 00:32:57,010 +دقيق أبداً الذي أفضل منه البلاتلت aggregate + +475 +00:33:00,060 --> 00:33:03,600 +conclusion a special calculation is a specialized + +476 +00:33:03,600 --> 00:33:07,440 +complex and dynamic field هو يعني موضوع ليس سهل + +477 +00:33:07,440 --> 00:33:13,800 +ومتشعب ومتجدد ويحتاج لبحث باستمرار ويعطيكم ألف عافية + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..63164b7ddb3ecc4906bcf543672482800d514e8e --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk_postprocess.srt @@ -0,0 +1,1908 @@ +1 +00:00:13,100 --> 00:00:17,020 +نستكمل نبدأ الآن ان شاء الله رب العالمين مع ال + +2 +00:00:17,020 --> 00:00:21,040 +bleeding disorders ناخد فكرة عنها و نشوف كيف بدنا + +3 +00:00:21,040 --> 00:00:27,080 +نعمل لها diagnosis و نفرقها عن بعض المشاكل + +4 +00:00:27,080 --> 00:00:32,000 +اللي ممكن تصير في ال bleeding قد تكون جاية من خلل + +5 +00:00:32,000 --> 00:00:36,100 +في ال coagulation factors أو خلل في ال platelets + +6 +00:00:36,100 --> 00:00:43,000 +خلينا نعمل مقارنة بسيطة بينهم بين الأعراضبداية + +7 +00:00:43,000 --> 00:00:46,020 +البلاتلات الـ disorders و الـ coagulation + +8 +00:00:46,020 --> 00:00:50,940 +disorders نشوف أول حاجة الـ site of bleeding عادة + +9 +00:00:50,940 --> 00:00:55,360 +البلاتلات الـ disorders بتبقى الأماكن اللي بيصير + +10 +00:00:55,360 --> 00:00:59,900 +فيها ال bleeding عادة سطحية يعني في ال skin، في ال + +11 +00:00:59,900 --> 00:01:06,920 +mucous membrane زي ابستاكسز، gum، vaginal، GIT، + +12 +00:01:06,920 --> 00:01:10,400 +bleeding يعني في أماكن وين في ميوكاس membrane أو + +13 +00:01:10,400 --> 00:01:13,620 +skin ممكن تظهربينما الـ Coagulation Factor + +14 +00:01:13,620 --> 00:01:16,800 +Disorders بتكون في أماكن عميقة زي الـ joints و ال + +15 +00:01:16,800 --> 00:01:21,680 +muscles بالتاكية في الـ Platelet Disorder بتكون + +16 +00:01:21,680 --> 00:01:25,580 +واضحة بينما في الـ Coagulation Factor Disorders لأ + +17 +00:01:25,580 --> 00:01:30,740 +الـ Echemosis اللي هي الكدمات الذرقاء الكبيرة عادة + +18 +00:01:30,740 --> 00:01:34,560 +يعني في الـ Platelets بتكون صغيرة و superficial + +19 +00:01:34,560 --> 00:01:38,560 +بينما في الـ Coagulation Factor Disorders بتكون + +20 +00:01:38,560 --> 00:01:43,230 +large and deepHemarthrosis أو Muscle bleeding اللي + +21 +00:01:43,230 --> 00:01:47,390 +هو تجمع دموي في المفاصل أو في العضلات في + +22 +00:01:47,390 --> 00:01:50,510 +الـplatelet disorder extremely rare بينما في + +23 +00:01:50,510 --> 00:01:54,710 +الـcoagulation factor أساسي bleeding after cut or + +24 +00:01:54,710 --> 00:01:59,590 +scratches عادة الجروح السطحية البسيطة لو كان في + +25 +00:01:59,590 --> 00:02:03,670 +platelet disorder بتظل تنزف بينما في + +26 +00:02:03,670 --> 00:02:06,470 +الـcoagulation factor disorders عادة ما بيصيرش + +27 +00:02:06,470 --> 00:02:10,640 +منها مشاكلالـ bleeding after surgery or trauma + +28 +00:02:10,640 --> 00:02:16,480 +عادة بيكون immediate bleeding وبيكون يعني خفيف + +29 +00:02:16,480 --> 00:02:21,960 +مابيكونش كتير بينما بعد العمليات الجراحية إذا كان + +30 +00:02:21,960 --> 00:02:25,560 +فيه خلل في ال coagulation factor بيصير ال bleeding + +31 +00:02:25,560 --> 00:02:31,160 +متأخر يعني مابيصيرش في الحال ومن يوم إلى يومين بعد + +32 +00:02:31,160 --> 00:02:35,260 +العملية وعادة بيكون severe بيكون صعب ومضاعفات + +33 +00:02:35,260 --> 00:02:35,680 +خاطرة + +34 +00:02:38,940 --> 00:02:43,360 +من الـ Coagulation Factor Disorders نوعين نوع + +35 +00:02:43,360 --> 00:02:47,420 +Inherited و نوع Acquired الـ Inherited زي اللي + +36 +00:02:47,420 --> 00:02:51,720 +احنا عارفينهم بشكل عام الـ Factor Deficiencies من + +37 +00:02:51,720 --> 00:02:55,800 +الـ Factor Deficiencies الاكتر شيوعان Hemophilia A + +38 +00:02:55,800 --> 00:03:00,940 +و Hemophilia B في عندي الـ Vinyl Brand Disease في + +39 +00:03:00,940 --> 00:03:04,520 +عندي Acquired Disorders زي Liver Disease و Vitamin + +40 +00:03:04,520 --> 00:03:09,640 +K Deficiency أو الناس اللي بتاخد وفرينOverdose + +41 +00:03:09,640 --> 00:03:18,560 +يعني أخدت وافرين كمية كبيرة حالات الـ DIC طيب + +42 +00:03:18,560 --> 00:03:22,360 +نيجي مقارنة بسيطة بين Hemophilia A و Hemophilia B + +43 +00:03:22,360 --> 00:03:26,120 +زي ما احنا عارفين Hemophilia A بيكون خلل في factor + +44 +00:03:26,120 --> 00:03:30,760 +8 Hemophilia B بيبقى فيه خلل أو نقص في factor 9 + +45 +00:03:30,760 --> 00:03:37,180 +طريق التوريث كلاهما X-linked recessive ال + +46 +00:03:37,180 --> 00:03:43,130 +incidenceHemophilia A 1 على 10 ألف Hemophilia B 1 + +47 +00:03:43,130 --> 00:03:47,770 +على 50 ألف Male يعني هذه أقل شيوعاً اللي هي + +48 +00:03:47,770 --> 00:03:54,170 +Hemophilia B Severity طبعاً بترجع لقداش صار + +49 +00:03:54,170 --> 00:03:59,110 +deficiency في ال factor إذا كانت كمية ال factor + +50 +00:03:59,110 --> 00:04:03,430 +الموجودة أقل من 1% هتلاقي severe spontaneous + +51 +00:04:03,430 --> 00:04:07,280 +bleedingلو كانت كمية الـ Factor الموجودة من 1 إلى + +52 +00:04:07,280 --> 00:04:12,260 +5% مدرات bleeding with mild injury مع الجروح + +53 +00:04:12,260 --> 00:04:17,840 +البسيطة ممكن يصير bleeding من 5 إلى 25% mild + +54 +00:04:17,840 --> 00:04:20,680 +bleeding with surgery or trauma بس يعني بيصير + +55 +00:04:20,680 --> 00:04:24,920 +bleeding خفيف مع الضربات الكبيرة أو مع حدوث عمليات + +56 +00:04:24,920 --> 00:04:28,960 +جراحية الـ Complications عادة it and then بيصير + +57 +00:04:28,960 --> 00:04:34,580 +لهم complications إنه بيصير soft shock bleedingطيب + +58 +00:04:34,580 --> 00:04:38,800 +الـ hemophilia الـ clinical manifestations طبعاً A + +59 +00:04:38,800 --> 00:04:44,440 +and B بالأعراض صعب أنه أفرقهم لازم أعمل factor الـ + +60 +00:04:44,440 --> 00:04:48,880 +C عشان أعرف المشكلة وين أول حاجة hemarthrosis + +61 +00:04:48,880 --> 00:04:52,660 +بيصير تجمع دموي في المفاصل نتيجة حركة المفاصل + +62 +00:04:52,660 --> 00:04:58,260 +بيصير زي تمزق في blood vessels هذا التمزق بينشأ + +63 +00:04:58,260 --> 00:05:03,220 +عنه bleeding يؤدي إلى تجمع blood في المفصلفبتحول + +64 +00:05:03,220 --> 00:05:07,480 +المفصل كإنه fixed joint يعني المفصل هذا صعب يتحرك + +65 +00:05:07,480 --> 00:05:12,380 +soft tissue hematoma تجمعات دموية في ال soft + +66 +00:05:12,380 --> 00:05:16,500 +tissue زي ال muscles ممكن هذا يؤدي لمuscle atrophy + +67 +00:05:16,500 --> 00:05:22,800 +أو shortened tendons other sites of bleeding زي ال + +68 +00:05:22,800 --> 00:05:26,350 +urinary tract و ال central nervous systemneck may + +69 +00:05:26,350 --> 00:05:30,510 +be life threatening ممكن يصير نزيف العنف ويكون + +70 +00:05:30,510 --> 00:05:34,290 +خطير prolonged bleeding after surgery or dental + +71 +00:05:34,290 --> 00:05:37,710 +extraction يعني عادة هدول لما بيروحوا بيخلعوا + +72 +00:05:37,710 --> 00:05:42,310 +أسنانهم أو بيعملوا عمليات يعني حاجات في الفم أو + +73 +00:05:42,310 --> 00:05:50,390 +عمليات جراحية بسيطة هيصير عندهم bleeding ويطول هذا + +74 +00:05:50,390 --> 00:05:54,870 +منظر للـ hemarthrosis كيف تجمع دموي في المفصل + +75 +00:05:55,170 --> 00:05:59,070 +بيقدّي الانتفاخ المفصل لو أخلنا عينة من الـ + +76 +00:05:59,070 --> 00:06:02,370 +Synovial Fluid هنلاقي بلدي هنلاقي كمية ال blood + +77 +00:06:02,370 --> 00:06:06,450 +فيه كبيرة كبيرة + +78 +00:06:06,450 --> 00:06:11,010 +نيجي للـ Von Willebrand Disease الـ Von Willebrand + +79 +00:06:11,010 --> 00:06:14,050 +Disease طبعا عبارة عن مرض من الأمراض الهيمستاسز + +80 +00:06:14,050 --> 00:06:17,050 +احنا عارفين الـ Von Willebrand Factor بتصنع في الـ + +81 +00:06:17,050 --> 00:06:21,290 +Endothelium وفي الـ Platelets عادة بتصنع على شكل + +82 +00:06:21,290 --> 00:06:26,020 +مونومر و بيصير له polymerizationفي الـ Endoplasmic + +83 +00:06:26,020 --> 00:06:30,980 +reticulum للخلايا وفي الجولجيابريتاس + +84 +00:06:30,980 --> 00:06:36,720 +وبيكون Large Multimer طبعا وظائفه هو يعتبر كـ + +85 +00:06:36,720 --> 00:06:40,240 +Carrier لـ Factor 8 الشغلة التانية المهمة اللي هي + +86 +00:06:40,240 --> 00:06:43,660 +بيثبت البلاتلت على الـ Subendothelium في بداية + +87 +00:06:43,660 --> 00:06:47,160 +مرحلة الـ Platelet Activation وبيعمل Bridging ما + +88 +00:06:47,160 --> 00:06:52,740 +بين البلاتلتبتم توريثه كـ Autosomal Dominant يعني + +89 +00:06:52,740 --> 00:06:56,300 +مالهوش علاقة بالـ X-Promosome زي حالات الهيموفيليا + +90 +00:06:56,300 --> 00:07:03,060 +Autosomal Dominant Incidence من 1 إلى 10 ألف من + +91 +00:07:03,060 --> 00:07:08,000 +الـ Clinical Features تبعها نيجي نشوف إيش الفحصات + +92 +00:07:08,000 --> 00:07:11,580 +اللي بتنعمل للـ Von Willebrand Disease أول إيش هي + +93 +00:07:11,580 --> 00:07:16,310 +الـ Von Willebrand Diseaseاللي قد يكون فيه اختلاف + +94 +00:07:16,310 --> 00:07:19,690 +كمي وقد يكون qualitative يعني قد يكون quantitative + +95 +00:07:19,690 --> 00:07:23,710 +deficiency أو qualitative deficiency هو صحيح تلت + +96 +00:07:23,710 --> 00:07:27,670 +أنواع نوعه type 1 بيكون في عندنا quantitative + +97 +00:07:27,670 --> 00:07:30,510 +deficiency لكن مش completely يعني فيه partial + +98 +00:07:30,510 --> 00:07:34,530 +deficiency type 2 qualitative deficiency يعني أنه + +99 +00:07:34,530 --> 00:07:37,930 +الـantigen موجود أو الـvolume brand factor موجود + +100 +00:07:37,930 --> 00:07:43,110 +لكن مابيشتغلش بالشكل الجيء الصحيحType 3 Totally + +101 +00:07:43,110 --> 00:07:47,970 +Quantitative Deficiency أنه هو نفسه مش موجود في + +102 +00:07:47,970 --> 00:07:52,150 +مشكلة فيه تصنيعه نشوف إيش الفحصات اللي ممكن تنعمل + +103 +00:07:52,150 --> 00:07:55,750 +في فحصات بتبحث عنه كـ Antigen يعني هل هو موجود أو + +104 +00:07:55,750 --> 00:08:00,590 +مش موجود بغض النظر عن وظيفة في عندنا فحصات بتشوف + +105 +00:08:00,590 --> 00:08:04,530 +الـ Activity في عندنا الـ Multimarket Analysis أول + +106 +00:08:04,530 --> 00:08:08,610 +إشي الـ Vanwill Brand Antigen أكيد هو هيكون موجود + +107 +00:08:09,330 --> 00:08:13,150 +في الحالة الأولى لكن فيه deficiency الحالة التانية + +108 +00:08:13,150 --> 00:08:15,850 +هيكون normal ليش؟ لأن مافيش عندي مشكلة في الـ + +109 +00:08:15,850 --> 00:08:18,190 +Antigen قى Antigen لكن عندي مشكلة في الوظيفة + +110 +00:08:18,190 --> 00:08:21,930 +الحالة التالتة هيكون فيه severe deficiency ليش؟ + +111 +00:08:21,930 --> 00:08:25,920 +لأن في عندي total quantitative deficiencyطيب، نيجي + +112 +00:08:25,920 --> 00:08:29,780 +للـ Activity الـ Activity الحالة الأولى هيكون فيه + +113 +00:08:29,780 --> 00:08:32,500 +نقص في الـ Activity الحالة التانية نقص في الـ + +114 +00:08:32,500 --> 00:08:34,840 +Activity لأنه فعليا المشكلة عندنا مش في الـ + +115 +00:08:34,840 --> 00:08:37,820 +Antigen في التانية في type 2 المشكلة عندنا في الـ + +116 +00:08:37,820 --> 00:08:41,960 +Activity زي ما حكينا الحالة التالتة تقريبا هيكون + +117 +00:08:41,960 --> 00:08:46,500 +الـ Activity قليلة جدا لأن ال factor أصلا مش موجود + +118 +00:08:46,500 --> 00:08:50,660 +نيجي لـ Multimer Analysis الـ Multimer Analysis + +119 +00:08:50,660 --> 00:08:54,040 +يعني هذه بتدل على إنه هل فعلا تكون بالشكل الصحيح + +120 +00:08:54,040 --> 00:08:58,840 +وكوّنالـ Polymers اللي إحنا عارفينها إحنا حكينا + +121 +00:08:58,840 --> 00:09:02,820 +إنه بتكون كم نمر وبعدين بيستكون الملتمر الحالتين + +122 +00:09:02,820 --> 00:09:06,820 +الأولانية مافيش فيه مشكلة يعني هيكون الملتمر موجود + +123 +00:09:06,820 --> 00:09:10,960 +ومافيش فيه مشكلة في type 1 وtype 2 بينما في type 3 + +124 +00:09:10,960 --> 00:09:15,560 +هيكون absent لأنه أصلا الـVar والـBrand فاكتر طيب + +125 +00:09:15,560 --> 00:09:22,410 +نيجي للـVitamin K deficiency الـVitamin Kطبعا الـ + +126 +00:09:22,410 --> 00:09:24,970 +Vitamin K بيجينا من الـ Green Vegetables بعدين + +127 +00:09:24,970 --> 00:09:28,350 +بيصيرله synthesis عن طريق الـ Intestinal Flora + +128 +00:09:28,350 --> 00:09:34,070 +مطلوب الـ Vitamin K لتصنيع اللي هو factor 2 و7 و9 + +129 +00:09:34,070 --> 00:09:39,410 +و10 ومطلوب برضه لبروتين C وبروتين S إيش أسباب الـ + +130 +00:09:39,410 --> 00:09:43,570 +deficiency؟ قد يكون Malnutrition أو Biliary + +131 +00:09:43,570 --> 00:09:47,590 +Obstruction أو Malabsorption أو بعض الـ Antibiotic + +132 +00:09:47,590 --> 00:09:54,230 +Therapyعلاجه ممكن ينعطى Vitamin K أو ينعطى Fresh + +133 +00:09:54,230 --> 00:10:01,630 +Frozen Plasma الآن + +134 +00:10:01,630 --> 00:10:06,170 +نيجي للـDisseminated Intravascular Coagulation + +135 +00:10:06,170 --> 00:10:10,270 +طبعا هذا يعتبر من الحالات الخطيرة والصعبة في أمراض + +136 +00:10:10,270 --> 00:10:14,830 +الـHemostasis بينتج عن activation of both + +137 +00:10:14,830 --> 00:10:18,810 +coagulation and fibrinolysisمن الحلات اللي ممكن + +138 +00:10:18,810 --> 00:10:25,170 +تعملوا triggering زي حلات sepsis حلات لـ trauma زي + +139 +00:10:25,170 --> 00:10:28,470 +الـ head injury و الـ fat embolism حلات الـ + +140 +00:10:28,470 --> 00:10:32,170 +malignancy obstetrical complications اللي هي بتصير + +141 +00:10:32,170 --> 00:10:36,510 +مضاعفات اللي ممكن تصير في الحمل أو عند الولادة زي + +142 +00:10:36,510 --> 00:10:40,690 +حلات الـ amniotic fluid embolism زي حلات الـ + +143 +00:10:40,690 --> 00:10:45,650 +Arreptio placenta اللي هي انفصال المشيمة حلات الـ + +144 +00:10:45,650 --> 00:10:51,410 +vascular disordersReaction to toxins عادة يحصل عند + +145 +00:10:51,410 --> 00:10:55,650 +لدغات الأفاعي والعقارب Snake venom أو بعض ال drugs + +146 +00:10:55,650 --> 00:10:58,890 +بعض ال immunological disorders زي الـ severe + +147 +00:10:58,890 --> 00:11:02,350 +allergic reaction أو الـ Transplant rejection كل + +148 +00:11:02,350 --> 00:11:07,190 +هذه حالات ممكن تعمل Triggering الـ Disseminated + +149 +00:11:07,190 --> 00:11:11,090 +Intravascular Coagulation Mechanism طبعاً حيصير + +150 +00:11:11,090 --> 00:11:14,610 +Systemic Activation of Coagulation حالات لما بيصير + +151 +00:11:14,610 --> 00:11:18,450 +Activation للـ Coagulationهيبدأ يتكون الفيبرين + +152 +00:11:18,450 --> 00:11:22,290 +الفيبرين هيبدأ يترسّب Intravascular هيترسّب بداخل + +153 +00:11:22,290 --> 00:11:25,970 +الـ blood vessels هذا رح يؤدي إلى انسداد بعض الـ + +154 +00:11:25,970 --> 00:11:30,970 +blood vessels الصغيرة و الحجمها متوسط و هيؤدي إلى + +155 +00:11:30,970 --> 00:11:34,130 +organ failure يعني لما يصير تسليط لـ blood vessel + +156 +00:11:34,130 --> 00:11:38,010 +بغض أورجان معين هذا الـ organ رح يصير فيه failure + +157 +00:11:38,010 --> 00:11:41,490 +شغلة تانية هيصير Depletion of platelets and + +158 +00:11:41,490 --> 00:11:45,060 +coagulation factor لأنه هيصير استهلاك لإلهموهذا رح + +159 +00:11:45,060 --> 00:11:50,800 +يؤدي إلى bleeding هنا + +160 +00:11:50,800 --> 00:11:55,120 +برضه بيوضح الكلام بشكل أفضل ال pathogenesis of DIC + +161 +00:11:55,120 --> 00:11:59,640 +طبعا بيصير release لبعض الأشياء اللي بتحفز ال + +162 +00:11:59,640 --> 00:12:02,720 +coagulation اللي هي thromboplastic material في ال + +163 +00:12:02,720 --> 00:12:06,520 +circulation للأسباب اللي حكيناها قبلها فبتتنشط + +164 +00:12:06,520 --> 00:12:10,220 +عملية ال coagulation ال coagulation هيحول لثرمبين + +165 +00:12:10,220 --> 00:12:13,500 +فيها في النهاية الفيبرينوجين إلى فيبرينطبعا طالما + +166 +00:12:13,500 --> 00:12:17,820 +اتكون الـ Fibrin هيتنشط عملية الـ Fibrinolysis عن + +167 +00:12:17,820 --> 00:12:21,960 +طريق طبعا البلازمينوشين بتحول لبلازمين أو بيبدأ + +168 +00:12:21,960 --> 00:12:25,820 +يعمل degradation للـ Fibrin طبعا هذا هيقدّي إلى + +169 +00:12:25,820 --> 00:12:30,040 +زيادة برضه الـ D-dimer والـ Fibrin degradation + +170 +00:12:30,040 --> 00:12:34,340 +الproducts هنشوف إيش هيصير، هيصير استهلاك للـ + +171 +00:12:34,340 --> 00:12:39,020 +coagulation factors زي هنلاحظ في ارتفاع في الـ BTT + +172 +00:12:40,470 --> 00:12:43,590 +في الـ thrombin time هذا الـ thrombin time هو بشيط + +173 +00:12:43,590 --> 00:12:47,010 +على الـ fibrinogen ارتفاعه بيدل على أن الـ + +174 +00:12:47,010 --> 00:12:51,650 +fibrinogen منخفض الـ fibrinogen هنلاقيه لا هنلاقي + +175 +00:12:51,650 --> 00:12:56,630 +البلازمين ارتفع و قد إلى ارتفاع الـ fibrin + +176 +00:12:56,630 --> 00:13:00,590 +degradation of products Intravascular clot تكون + +177 +00:13:00,590 --> 00:13:04,010 +الـ clots في الـ blood vessels إيش هتعمل؟ هتنقص + +178 +00:13:04,010 --> 00:13:08,050 +البلاتلتز هتعمل عندك testocyte من الحاجات المميزة + +179 +00:13:08,050 --> 00:13:13,230 +للـ DIC وجودطيب نيجي للـplatelet disorders + +180 +00:13:13,230 --> 00:13:16,450 +الـplatelet disorders قد تكون quantitative أو + +181 +00:13:16,450 --> 00:13:20,830 +qualitative ال quantitative قد تكون بسبب abnormal + +182 +00:13:20,830 --> 00:13:25,820 +distribution يعني على سبيل المثال في مكانبقول + +183 +00:13:25,820 --> 00:13:29,980 +نفترض مثلا فيه Hepatosplenomegaly لو كان في حالة + +184 +00:13:29,980 --> 00:13:32,340 +Hepatosplenomegaly هتلاقي فيه تجمع كبير + +185 +00:13:32,340 --> 00:13:35,980 +للـplatelets في الـspleen وفي الـliver فهذا هيؤدي + +186 +00:13:35,980 --> 00:13:39,460 +إلى نقصها في الـcirculation فهذا مقصود بمعنى + +187 +00:13:39,460 --> 00:13:44,080 +الـabnormal distribution dilution effect decreased + +188 +00:13:44,080 --> 00:13:47,260 +production increased destruction يعني هذه الحاجات + +189 +00:13:47,260 --> 00:13:51,050 +اللي ممكن تؤدي إلى نقص للـplateletsEqualitative + +190 +00:13:51,050 --> 00:13:55,650 +disorders قد تكون inherited وهي نادرة يعني في أنها + +191 +00:13:55,650 --> 00:13:58,990 +مشكلة في وظيفة الـplatelets نفسها وقد تكون + +192 +00:13:58,990 --> 00:14:02,830 +acquired بسبب medications أو chronic renal failure + +193 +00:14:02,830 --> 00:14:06,770 +أو cardio pulmonary bypass عارفين إيش يعني cardio + +194 +00:14:06,770 --> 00:14:10,030 +pulmonary bypass اللي هو لما بيعملوا عمليات القلب + +195 +00:14:10,030 --> 00:14:13,850 +مفتوح بيحطوا جهاز يقوم بدور القلب والرئتين خلال + +196 +00:14:13,850 --> 00:14:14,930 +إجراء العملية + +197 +00:14:18,960 --> 00:14:23,100 +خلّينا الآن نبدأ نشوف كيف بدنا نعمل lab evaluation + +198 +00:14:23,100 --> 00:14:28,540 +لل bleeding disorders أول حاجة ال CBC و البلد + +199 +00:14:28,540 --> 00:14:31,920 +السمير طبعا ال CBC و البلد السمير هيفيدوني في + +200 +00:14:31,920 --> 00:14:35,360 +موضوع البلاتلت يعني بشوف من خلالهم البلاتلت count + +201 +00:14:35,360 --> 00:14:40,760 +إذا كان فيه thrombocytopenia بشوف من خلالهم زي + +202 +00:14:40,760 --> 00:14:44,220 +حالات ال TTB اللي هي thrombocytopenic hyperborea + +203 +00:14:44,220 --> 00:14:47,420 +إذا كان فيه مثلا schistocyte ممكن يدل على إنه فيه + +204 +00:14:47,420 --> 00:14:51,120 +DIC and so onفبالتالي الـ Blood Smear بنشوف من + +205 +00:14:51,120 --> 00:14:54,020 +خلالها Blatulate Count RBCs and Blatulate + +206 +00:14:54,020 --> 00:14:57,380 +Warfology يعني بتفيدني بس في الموضوع الـ Blatulate + +207 +00:14:57,380 --> 00:15:03,100 +إلى حد ما يعني في الـ DIC بشوف Shistocyte طيب الـ + +208 +00:15:03,100 --> 00:15:06,140 +Coagulation Profile فحصات الـ Coagulation اللي + +209 +00:15:06,140 --> 00:15:09,960 +هنعملها الـ Prothrombin Time للـ Extrinsic Pathway + +210 +00:15:09,960 --> 00:15:14,380 +BTT للـ Intrinsic Pathway Coagulation Factor Assay + +211 +00:15:14,380 --> 00:15:17,000 +عشان نعرف بعض الـ Factors إذا كان فيها Difficiency + +212 +00:15:17,640 --> 00:15:21,780 +الـ Mixing Study 50 إلى 50 هنشوف إذا كان فيه + +213 +00:15:21,780 --> 00:15:25,880 +Inhibitors الـ Fibrinogen Assay عشان نشوف الـ + +214 +00:15:25,880 --> 00:15:28,740 +Level للـ Fibrinogen الـ Thrombin Time طبعاً بدل + +215 +00:15:28,740 --> 00:15:33,340 +على إذا كان في عندي مشكلة في الـ Fibrinogen الـ + +216 +00:15:33,340 --> 00:15:36,060 +Fibrinogen Defect قد يكون qualitative أو + +217 +00:15:36,060 --> 00:15:39,860 +quantitativeFibrin degradation in products or D + +218 +00:15:39,860 --> 00:15:43,600 +-dimer كل هذه الأشياء ممكن نعملها راح ناخدها بشيء + +219 +00:15:43,600 --> 00:15:46,390 +من التفصيل الـ Platelet Functionمن ضمن الأشياء + +220 +00:15:46,390 --> 00:15:48,770 +اللي ممكن تنعملها وظيفة الـ Platelet الـ Funnel + +221 +00:15:48,770 --> 00:15:52,190 +Brand Factor، bleeding time، Platelet Function + +222 +00:15:52,190 --> 00:15:59,950 +Analyzer، Platelet الآن بدنا ناخد مع بعض مرور سريع + +223 +00:15:59,950 --> 00:16:04,290 +على فحوصات الهيمостاسيز وكيف أنا بستخدمها في ال + +224 +00:16:04,290 --> 00:16:09,750 +diagnosis للحالات المرضية الآن لو أجى مريض عنده أو + +225 +00:16:09,750 --> 00:16:14,650 +بيعاني من bleedingهذا المريض أكيد راح يطلبله + +226 +00:16:14,650 --> 00:16:18,890 +الدكتور CPC بعد السؤول ومع الـ CPC حيطلبله الـ + +227 +00:16:18,890 --> 00:16:22,230 +Coagulation Profile إيش حيطلبله بالظبط؟ حيطلبله + +228 +00:16:22,230 --> 00:16:26,290 +غالبا Bt و Btt أول حاجة زي ما اتفقنا إن الـ Btt + +229 +00:16:26,290 --> 00:16:29,510 +بيشيك على الـ Intrinsic Pathway و الـ Common + +230 +00:16:29,510 --> 00:16:33,430 +Pathway لعند الفيبرينجين و الـ Prothrombin Time + +231 +00:16:33,430 --> 00:16:36,550 +حيشيك على ال Extrinsic Pathway و الCommon Pathway + +232 +00:16:36,550 --> 00:16:39,570 +برضه لعند الفيبرينجين يعني هدول ما حيشيكوا على + +233 +00:16:39,570 --> 00:16:43,700 +الفيبرينجينعندي فحص ثاني بشيك على الـ fibrinogen + +234 +00:16:43,700 --> 00:16:47,120 +اللي هو الـ thrombin time إذا كان الـ thrombin + +235 +00:16:47,120 --> 00:16:50,360 +time prolonged معنى الكلام أن الـ fibrinogen فيه + +236 +00:16:50,360 --> 00:16:54,120 +deficiency فبنروح بنعمل assay للـ fibrinogen و + +237 +00:16:54,120 --> 00:16:58,180 +بنحدد قيمته تمام؟ إذا هدول تقريبا التلات فحصات + +238 +00:16:58,180 --> 00:17:02,600 +الرئيسية في ال .. في ال .. في ال coagulation + +239 +00:17:02,600 --> 00:17:07,950 +profileهنا بناقش معانا بعض الـ Technical Errors + +240 +00:17:07,950 --> 00:17:10,750 +يعني احنا أخدناها بالتفصيل في مادة النزف العملي + +241 +00:17:10,750 --> 00:17:15,410 +اللي هو موضوع الـ Sodium Citrate اللي أنا استخدمته + +242 +00:17:15,410 --> 00:17:17,350 +طبعا احنا بنستخدم الـ Sodium Citrate كـ + +243 +00:17:17,350 --> 00:17:20,330 +Anticoagulant هل الـ Sodium Citrate كانت كميته + +244 +00:17:20,330 --> 00:17:23,830 +متناسبة مع كمية الـ Blood لأنه لو ماكانش فيه تناسب + +245 +00:17:23,830 --> 00:17:27,330 +سواء بزيادة أو بنقصان هيعمل prolongation للـ Time + +246 +00:17:27,330 --> 00:17:31,930 +مثلا صار تسرب للـ Sodium Citrate من القبوبة تلال + +247 +00:17:31,930 --> 00:17:36,510 +عملية السحب لو صار عندي مشاكل أنا سحبت ببطءلو عملت + +248 +00:17:36,510 --> 00:17:39,910 +label غلط، لو عملت checking مش بشكل صحيح، لو صار + +249 +00:17:39,910 --> 00:17:42,970 +heparin-contamination للعينة، لو كنت أنا بسحب من + +250 +00:17:42,970 --> 00:17:47,590 +Travenous line، ممكن كل هذه الأشياء أتأثر على + +251 +00:17:47,590 --> 00:17:52,390 +نتائج تبعتي أسباب تانية، biological factors، زي + +252 +00:17:52,390 --> 00:17:54,690 +مثلا الـHematocrit، إذا كنتوا فاكرين إذا كان + +253 +00:17:54,690 --> 00:17:57,430 +الـHematocrit مرتفع كتير أو منخفض كتير، لازم أنا + +254 +00:17:57,430 --> 00:18:01,530 +أعمله correction عشان أحسب كمية الصدر، كمسترات + +255 +00:18:01,530 --> 00:18:06,150 +المناسبة في كل حالةلو كان فيه ليبيميا مثلا في + +256 +00:18:06,150 --> 00:18:09,210 +العينة أو ارتفاع في الـ bilirubin كلها هذه أشياء + +257 +00:18:09,210 --> 00:18:14,690 +بتأثر على النتيجة بعندي أشياء برضه أخرى زي لو أنا + +258 +00:18:14,690 --> 00:18:18,550 +طولت على العينة في عندي labile factors حتتأثر لو + +259 +00:18:18,550 --> 00:18:21,150 +طولت ال incubation في ال 37 برضه هيأثر على ال + +260 +00:18:21,150 --> 00:18:25,590 +labile factors لو أنا خلال ما فرزتش العينة لو أنا + +261 +00:18:25,590 --> 00:18:29,330 +بدي افرزها و جيت فرزتها و دوبتها مش مش مش مش مش مش + +262 +00:18:29,330 --> 00:18:30,310 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +263 +00:18:30,310 --> 00:18:30,330 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +264 +00:18:30,530 --> 00:18:35,210 +فترضوا أنه أنا عملت فحوصات الـ coagulation واحد + +265 +00:18:35,210 --> 00:18:39,030 +بنزف وطلع عنده كل شي طلعت البلاستيكس طبيعية وطلع + +266 +00:18:39,030 --> 00:18:44,910 +الـ BT و الـ BTT normal بروح بعمل فحوصات عشان + +267 +00:18:44,910 --> 00:18:50,750 +تشوفلي factor 13 و factor 2 اللي هو الـ factor + +268 +00:18:50,750 --> 00:18:53,310 +عفواً one اللي هو الـ fibrinogen طبعا إذا كنتوا + +269 +00:18:53,310 --> 00:18:56,970 +فاكرين قلتلكم الـ BT و الـ BTT بشيكولي على الـ + +270 +00:18:56,970 --> 00:19:00,680 +coagulation cascade لعند الفيبرنجينالـ Fibrinogen + +271 +00:19:00,680 --> 00:19:04,460 +وFactor 13» لهم فحصات خاصة فيهم الـ Fibrinogen + +272 +00:19:04,460 --> 00:19:07,940 +باختبره من خلال الـ Thrombin Time Factor 13» من + +273 +00:19:07,940 --> 00:19:11,520 +خلال فحص اللي هو الـ Urea Solubility الآن لو كان + +274 +00:19:11,520 --> 00:19:16,240 +فيه Blading والـ BT وBTT Normal بروح بعمل الـ Urea + +275 +00:19:16,240 --> 00:19:20,340 +Solubility بشوف إذا كان Abnormal احتمال تبقى + +276 +00:19:20,340 --> 00:19:24,300 +Deficiency بFactor 13» طيب إذا كان Normal إذا كان + +277 +00:19:24,300 --> 00:19:28,670 +Normal فيه احتمالالاحتمال الأول أن يكون mild + +278 +00:19:28,670 --> 00:19:31,330 +factor deficiency يعني في factor deficiency لكن ما + +279 +00:19:31,330 --> 00:19:37,750 +ظهرت في الـBT وBTT ليش لأن الـBT وBTT 50% من ال + +280 +00:19:37,750 --> 00:19:41,800 +factor activity هتعطيني normal BT وBTTيعني لو كان + +281 +00:19:41,800 --> 00:19:44,640 +الـFactor نازل لمُص الـActivity بتاعته هيعطيني + +282 +00:19:44,640 --> 00:19:48,120 +Normal Pt وPtT طبعاً هذا بيقلل من الـSensitivity + +283 +00:19:48,120 --> 00:19:53,340 +تبعتهم عشان هيك احتمال يبقى فيه Deficiency لكن ما + +284 +00:19:53,340 --> 00:19:57,680 +بيّنت وما ظهر معايا Abnormality في الـPt وPtT ممكن + +285 +00:19:57,680 --> 00:20:01,840 +يبقى فيه خلل في الـFibrinolysis ممكن بسبب + +286 +00:20:01,840 --> 00:20:05,340 +elevation في الـFibrin degradationالـ Product ممكن + +287 +00:20:05,340 --> 00:20:08,980 +Monoclonal Gamma Pathy ممكن Platelet Disorder ممكن + +288 +00:20:08,980 --> 00:20:13,580 +Vascular Disorder يعني في مشاكل أخرى غير الـ + +289 +00:20:13,580 --> 00:20:19,140 +Factor Deficiency طيب نيجي نفترض أنه احنا عملنا + +290 +00:20:19,140 --> 00:20:22,540 +الـ BT و الـ BTT بغض النظر مين فيهم طلع Normal + +291 +00:20:22,540 --> 00:20:25,420 +ومين فيهم Abnormal طلع فيهم واحد Normal وواحد + +292 +00:20:25,420 --> 00:20:29,740 +Abnormal السيناريو المتبع أنه نشوف الـ Abnormality + +293 +00:20:29,740 --> 00:20:32,640 +هذه إيش سببها طبعا الـ Abnormality قد يكون سببها + +294 +00:20:32,640 --> 00:20:37,530 +Factor Deficiencyأو قد يكون سببها «factor + +295 +00:20:37,530 --> 00:20:41,730 +inhibitors» فأنا بدي أعمل الـ «mixing study» عشان + +296 +00:20:41,730 --> 00:20:45,550 +أعرف إذا كانت «factor deficiency» ولا «inhibitors» + +297 +00:20:45,550 --> 00:20:49,230 +طيب، كيف بعمل الـ «mixing study»؟ الـ «sample» + +298 +00:20:49,230 --> 00:20:53,770 +اللي بدي أستخدمها باخد نصها خليني أفترض إني بدي + +299 +00:20:53,770 --> 00:20:58,290 +أخد 100 ميكروليتر الـ 100 ميكروليتر هدول باخد 50 + +300 +00:20:58,290 --> 00:21:02,710 +منهم من الـ «sample» زائد 50 من «normal control» + +301 +00:21:02,710 --> 00:21:06,180 +مافيش فيه deficiencyإيش الهدف من عملية الـ Mix + +302 +00:21:06,180 --> 00:21:10,700 +هادى؟ هلاقيت لو كان فيه فعلًا Factor Deficiency + +303 +00:21:10,700 --> 00:21:13,740 +خمسين Micron اللي أخدتهم من الـ Normal Control + +304 +00:21:13,740 --> 00:21:17,320 +هتعوض الـ Deficiency هادى وتعطيني Normal Result + +305 +00:21:17,320 --> 00:21:21,900 +لكن لو كان فيه Inhibitor الخمسين Micron اللي + +306 +00:21:21,900 --> 00:21:24,700 +أضفتهم من الـ Normal Control برضه هيصير لهم + +307 +00:21:24,700 --> 00:21:29,280 +Inhibition فبالتالي مش هيصير تعويض للخلل وبالتالي + +308 +00:21:29,280 --> 00:21:34,470 +النتيجة هتظل Abnormal تمام؟ الـ Mixing Studyبعمل + +309 +00:21:34,470 --> 00:21:38,430 +mix للعينة نصها من العينة اللي أنا بشتغل عليها + +310 +00:21:38,430 --> 00:21:42,230 +اللي طلعت abnormal ونصها من عينة normal control + +311 +00:21:42,230 --> 00:21:45,930 +هلأ إذا صار correction وتصحيح للنتيجة معنى الكلام + +312 +00:21:45,930 --> 00:21:49,930 +إنه factor deficiency إذا ما صارش correction معنى + +313 +00:21:49,930 --> 00:21:53,670 +الكلام إنه في عندي inhibitors هي اللي قدت لل + +314 +00:21:53,670 --> 00:21:58,150 +prolongation، تمام؟ إذا خلّيني أخد نموذج في عندي + +315 +00:21:58,150 --> 00:22:03,380 +normal BT و abnormal BTTUpnormal BTT هذا بيدل على + +316 +00:22:03,380 --> 00:22:06,780 +إنه الخلل اللي جاي في الـ Intrinsic Pathway طب + +317 +00:22:06,780 --> 00:22:10,440 +إحنا ليش استثنين الـ Common Pathway؟ لأن الـ BTT + +318 +00:22:10,440 --> 00:22:14,720 +Normal لو كان في خلل في الـ Common Pathway هيبين + +319 +00:22:14,720 --> 00:22:17,600 +في الـ BTT صح؟ لأن الـ Common Pathway مشترك بين + +320 +00:22:17,600 --> 00:22:22,380 +التنين لذن وجود Normal BTT و Normal BTT بقول إن في + +321 +00:22:22,380 --> 00:22:26,640 +عندي خلل في الـ Intrinsic Pathway فبدي أعمل الـ + +322 +00:22:26,640 --> 00:22:31,120 +Mixing Studyفلقيت إذا ضل الفحص Abnormal إذا في + +323 +00:22:31,120 --> 00:22:33,900 +عندي Inhibitors للـ Factors تحت الـ Intrinsic + +324 +00:22:33,900 --> 00:22:38,320 +Pathway قد تكون Specific Inhibitors زي Factor 8 أو + +325 +00:22:38,320 --> 00:22:42,120 +9 أو 11 Inhibitors أو لان Specific Inhibitors زي + +326 +00:22:42,120 --> 00:22:44,060 +الـ Antilobus Anticoagulant اللي هي الـ + +327 +00:22:44,060 --> 00:22:48,920 +Antiphospholipid Antibody لكن الاحتمال التاني إنه + +328 +00:22:48,920 --> 00:22:53,630 +يصير Correction يعني لما أعمل Mixing Studyالـ + +329 +00:22:53,630 --> 00:22:57,030 +Correction للنتيجة معنى الكلام أنه فيه factor + +330 +00:22:57,030 --> 00:23:00,910 +deficiency فبدي أشوف أي factor فيه deficiency أو + +331 +00:23:00,910 --> 00:23:04,230 +ممكن أعمل assay لل factor بالـ one stage assay إذا + +332 +00:23:04,230 --> 00:23:07,730 +كنتوا فاكرين الـ one stage assay بستخدمه عشان أحدد + +333 +00:23:07,730 --> 00:23:12,030 +ال activity لكل factor على حدة ممكن تكون المشكلة + +334 +00:23:12,030 --> 00:23:15,910 +جاية من multiple factor deficiencies نفس الكلام + +335 +00:23:15,910 --> 00:23:19,850 +هنا يكرر أنه طلع عند الأبناء الـ BT الـ BT + +336 +00:23:19,850 --> 00:23:25,150 +abnormal والـ BTT normalهلقيت هنا بقول إنه المشكلة + +337 +00:23:25,150 --> 00:23:28,750 +في الـextrinsic pathway يعني الـextrinsic pathway + +338 +00:23:28,750 --> 00:23:32,090 +normal والcommon pathway normal بس المشكلة وين + +339 +00:23:32,090 --> 00:23:36,750 +تركزت في الـextrinsic pathway بدي أعمل الـmixing + +340 +00:23:36,750 --> 00:23:40,930 +studyاللأ إذا كانت ال mixing study abnormal ممكن + +341 +00:23:40,930 --> 00:23:43,390 +يكون specific factor inhibitor هيكون ال factor + +342 +00:23:43,390 --> 00:23:46,890 +الوحيد اللي بحكي عنه هنا factor 7 وهدي عادة rare + +343 +00:23:46,890 --> 00:23:50,630 +لما يكون فيه inhibitor ل factor 7 أو non-specific + +344 +00:23:50,630 --> 00:23:54,470 +inhibitor زي الـ antiphospholipids إذا صار + +345 +00:23:54,470 --> 00:23:58,900 +correction بعد ال mixing study بدي أعملdeficiency + +346 +00:23:58,900 --> 00:24:02,720 +يعني أعمل factor S عشان أشوف إذا كان فيه factor + +347 +00:24:02,720 --> 00:24:06,960 +deficiency زي أشوف isolated factor deficiency وعلى + +348 +00:24:06,960 --> 00:24:11,300 +فكرة factor 7 نادر لما بينقص لحاله عادة بتكون جاية + +349 +00:24:11,300 --> 00:24:14,300 +من multiple factor deficiency و ال multiple factor + +350 +00:24:14,300 --> 00:24:17,960 +deficiency هذه بتكون جاية من شغلة أثرت على vitamin + +351 +00:24:17,960 --> 00:24:22,500 +K لأن factor 7 من ضمن 2 و7 و9 و10 اللي هم بيصنعهم + +352 +00:24:22,500 --> 00:24:27,520 +vitamin Kإذا كان فيه vitamin K دفيشنسي هيأثر على + +353 +00:24:27,520 --> 00:24:31,380 +مجموعة factors من ضمنهم factors سبعة، تمام؟ زي + +354 +00:24:31,380 --> 00:24:34,540 +حالات liver disease و الـ vitamin K دفيشنسي و + +355 +00:24:34,540 --> 00:24:41,200 +حالات جرعات الوافرين و الـDIC طيب، + +356 +00:24:41,200 --> 00:24:45,860 +نيجي إن اتنين كانوا abnormal الـBT و الـBTT كانوا + +357 +00:24:45,860 --> 00:24:49,260 +abnormal إيش الاحتمالات؟ طبعاً برضه بدنا نعمل + +358 +00:24:49,260 --> 00:24:55,030 +mixing study بدنا نعمل mixing study نشوفالآن إذا + +359 +00:24:55,030 --> 00:24:58,670 +صار يعني ماصارش correction أو كانت النتيجة لازلة + +360 +00:24:58,670 --> 00:25:01,950 +abnormal معنى الكلام إنه فيه factor inhibitors + +361 +00:25:01,950 --> 00:25:06,370 +ممكن تكون specific factor inhibitors زي factor 5 و + +362 +00:25:06,370 --> 00:25:13,630 +10 و factor 2 و factor 2 ممكن تكون fibrinogen وهدي + +363 +00:25:13,630 --> 00:25:17,770 +أقل شيوعاً non-specific inhibitors هي الشائعة اللي + +364 +00:25:17,770 --> 00:25:21,610 +هي زي lobus anticoagulantالان لو صار correction + +365 +00:25:21,610 --> 00:25:24,450 +هيكون factor deficiency طب ال factor deficiency + +366 +00:25:24,450 --> 00:25:29,690 +هنا في أي منطقة هتكون غالباً هتكون في ال common + +367 +00:25:29,690 --> 00:25:33,130 +pathway لأن الاتنين مع بعض اتأثروا يعني إلا يكون + +368 +00:25:33,130 --> 00:25:36,630 +factors ال common pathway انضمنت أو بعض ال factors + +369 +00:25:36,630 --> 00:25:41,290 +من ال common pathway تأثرت في هذه ال deficiencyof + +370 +00:25:41,290 --> 00:25:44,230 +four-factor deficiency زي isolated deficiency in + +371 +00:25:44,230 --> 00:25:46,950 +common pathway زي factor خمسة، factor عشرة + +372 +00:25:46,950 --> 00:25:50,670 +البروثرومبين فيبرنجل أو multiple-factor deficiency + +373 +00:25:50,670 --> 00:25:54,530 +هذه عادة شائعة زي حالات المشاكل اللي قلنا عنها + +374 +00:25:54,530 --> 00:25:57,870 +تولي بتأثير على الـVitamin K dependent factors + +375 +00:26:05,020 --> 00:26:08,440 +في عندنا ملخص للـ Coagulation Factor Deficiencies + +376 +00:26:08,440 --> 00:26:11,440 +الـ Coagulation Factor Deficiencies في عندى six + +377 +00:26:11,440 --> 00:26:15,300 +linked الـ six linked طبعاً بيكون فيها هيموفيليا A + +378 +00:26:15,300 --> 00:26:18,460 +و هيموفيليا B هيموفيليا A و هيموفيليا B التانين + +379 +00:26:18,460 --> 00:26:21,720 +بيأثروا على الـ BTT لأنهم Intrinsic Factors الـ BT + +380 +00:26:21,720 --> 00:26:25,300 +بيكون Normal الـ Autosome Recessive Autosome + +381 +00:26:25,300 --> 00:26:28,520 +Recessive زي ال factors اللي ممكن يصير فيها + +382 +00:26:28,520 --> 00:26:35,470 +Deficiencies زي Factor 2 و 5 و 7 و 10 و 11هدول + +383 +00:26:35,470 --> 00:26:38,610 +ممكن يأثروا على التانين لأن في منهم بيجيوا بالـ + +384 +00:26:38,610 --> 00:26:43,110 +Common Pathway Factor 13 Deficiency is associated + +385 +00:26:43,110 --> 00:26:47,350 +with bleeding and impaired wound healing هيكون + +386 +00:26:47,350 --> 00:26:50,670 +الـBT وBTT Normal زي ما قلنا الـClot Solubility + +387 +00:26:50,670 --> 00:26:55,770 +Test أو الـUrea Solubility بيكون Abnormal Factor 2 + +388 +00:26:55,770 --> 00:26:58,710 +Brachial Acrine High Molecular Weight Deficiency + +389 +00:26:58,710 --> 00:27:01,970 +don't cause bleeding هذه الـFactors لو صانالفاكتور + +390 +00:27:01,970 --> 00:27:04,970 +عفوا مش اتنين فاكتور اتناش بريكاليكرين high + +391 +00:27:04,970 --> 00:27:08,050 +molecular weight kynogen هذه الفاكتور لو صار فيها + +392 +00:27:08,050 --> 00:27:15,510 +deficiency عادة ما بتسببش bleeding نيجي + +393 +00:27:15,510 --> 00:27:19,590 +للثرومبين تايم الثرومبين تايم هذا فحص قلنا بيشيك + +394 +00:27:19,590 --> 00:27:23,550 +على الفيبرينجين هل الفيبرينجين ال level بتاعه + +395 +00:27:23,550 --> 00:27:27,780 +normal ولا لأ كيف فكرتهفكرته بسيطة جدا أنا فيها + +396 +00:27:27,780 --> 00:27:31,060 +بعتمد على آخر خطوة من التفاعل اللي هو تحول الـ + +397 +00:27:31,060 --> 00:27:35,700 +Fibrinogen إلى Fibrin الـ Fibrinogen عشان يتحول لـ + +398 +00:27:35,700 --> 00:27:40,780 +Fibrin إيش بده؟ بده Thrombinفأنا بضيف كمية كبيرة + +399 +00:27:40,780 --> 00:27:44,880 +من الـ Thrombin و بسمح للـ Fibrinogen إنه يتحول + +400 +00:27:44,880 --> 00:27:48,940 +إلى Fibrin فلقيت أنا بغض النظر إيش في عندى + +401 +00:27:48,940 --> 00:27:53,080 +deficiency من ال factors في الـ cascade ما بهمني + +402 +00:27:53,080 --> 00:27:56,880 +ليش لأن أنا وفّرت آخر حاجة وفّرت الحاجة المسؤولة + +403 +00:27:56,880 --> 00:28:00,580 +عن تحويل الـ Fibrinogen إلى Fibrin فإذا صار تحويل + +404 +00:28:00,580 --> 00:28:03,620 +بالشكل المناسب معنى الكلام إن الـ Fibrinogen مش + +405 +00:28:03,620 --> 00:28:07,980 +فيه مشكلةلكن لو أنا وفّرت كل الظروف للـ fibrinogen + +406 +00:28:07,980 --> 00:28:11,820 +حطيت الاثرنبين بكمية كافية وما اتحولش لـ fibrin + +407 +00:28:11,820 --> 00:28:14,880 +معنى الكلام أن الـ fibrinogen نفسه هو اللي فيه + +408 +00:28:14,880 --> 00:28:19,720 +مشكلة bypass factor 2 و factor 12 يعني أنا بغض + +409 +00:28:19,720 --> 00:28:25,700 +النظر يعني بغض النظر إيش في عندي factors ما بين + +410 +00:28:25,700 --> 00:28:28,860 +factor 12 و factor 2 هل هي فيها deficiency أو + +411 +00:28:28,860 --> 00:28:32,580 +مافيهاش deficiency أنا تجاوزتهم وحطيت كمية كبيرة + +412 +00:28:32,580 --> 00:28:37,090 +منالـ Fibrin عفوا من الـ Thrombin «Add thrombin + +413 +00:28:37,090 --> 00:28:40,870 +with patient sample» «measure time to clot» بضيف + +414 +00:28:40,870 --> 00:28:45,850 +الـ Thrombin و بشوف العينة هل صار لها clot ولا لأ + +415 +00:28:45,850 --> 00:28:48,130 +إذا كان الـ time normal إذا الـ fibrin وجه الـ + +416 +00:28:48,130 --> 00:28:50,170 +normal إذا ماكنش الـ time normal إذا فيه + +417 +00:28:50,170 --> 00:28:54,270 +deficiency في الـ fibrin في بعض المتغيرات في الفحص + +418 +00:28:54,270 --> 00:28:57,830 +ترجع لطبيعة الفيس للـ Thrombin و أنا من وين جايبها + +419 +00:29:01,180 --> 00:29:03,580 +ما هي الأسباب اللي بتأدي للـ prolongation للـ + +420 +00:29:03,580 --> 00:29:06,760 +thrombin time؟ إذا كان ال patient بياخد هيبرين + +421 +00:29:06,760 --> 00:29:10,720 +ثيرابي لأنه الهيبرين بيشتغل كانتثرمبين فأنا لما + +422 +00:29:10,720 --> 00:29:14,600 +بضيف للثرمبين وفيه هيبرين هيعمله أكيد prolongation + +423 +00:29:14,600 --> 00:29:18,560 +نقص الـ fibrinogen أو فيه فيبرينوجين بس مش شغال + +424 +00:29:18,560 --> 00:29:21,820 +dysfibrinogenemia elevated fibrin degradation + +425 +00:29:21,820 --> 00:29:27,880 +products or paraproteins thrombin inhibitorsزي + +426 +00:29:27,880 --> 00:29:31,480 +الهيرودين و الـ thrombin antibodies كلها هذه + +427 +00:29:31,480 --> 00:29:37,720 +الأشياء ممكن تعمل elongation نيجي + +428 +00:29:37,720 --> 00:29:42,420 +لموضوع الـ thrombocytopenia و أجى مريض بدي أشوف + +429 +00:29:42,420 --> 00:29:45,920 +إذا كان يعني عنده thrombocytopenia عنده نفس في الـ + +430 +00:29:45,920 --> 00:29:50,780 +platelets بدي أخد ال history هل حصل عنده bleeding + +431 +00:29:50,780 --> 00:29:54,480 +مثلا هل عنده أمراض أخرى زي cancer زي autoimmune + +432 +00:29:54,480 --> 00:29:59,140 +diseaseهل بياخد أدوية معينة، بيتعاطى كحول، بيعانى + +433 +00:29:59,140 --> 00:30:03,400 +أو عنده risk factor للـHIV؟ هل في عنده family + +434 +00:30:03,400 --> 00:30:06,040 +history للـThrombocytopenia؟ عشان أعرف إيش سببها + +435 +00:30:06,040 --> 00:30:11,640 +طيب، هل في مثلا شكل ال bleeding أو ال spot بتاعة + +436 +00:30:11,640 --> 00:30:16,180 +البيتاكيا اللي صايرة، هل يعني أتوقع من خلالها إنه + +437 +00:30:16,180 --> 00:30:20,670 +في فعل platelet deficiency؟طبعا بعد هيك يعني بدنا + +438 +00:30:20,670 --> 00:30:24,930 +ناخد ال history بتاع المريض ال CPC هيبين عندي عدد + +439 +00:30:24,930 --> 00:30:28,230 +البلاتلت بعمل peripheral blood smear عشان أشوف شكل + +440 +00:30:28,230 --> 00:30:30,830 +البلاتلت برضه ال morphology تبعها مهم جدا لإنه + +441 +00:30:30,830 --> 00:30:34,750 +ممكن يكون عددها طبيعي بس هي non-functional بعمل + +442 +00:30:34,750 --> 00:30:38,750 +bleeding time أو bleeding أو blatlet aggregation + +443 +00:30:38,750 --> 00:30:45,150 +study هنا عندي رسم بياني بيوضح عندي علاقة عدد + +444 +00:30:45,150 --> 00:30:48,690 +البلاتلت بالأعراض اللي ممكن تظهر على المريضيعني + +445 +00:30:48,690 --> 00:30:54,050 +بقولك أنه مثلا هنا الـ Platelet count و هنا حدة + +446 +00:30:54,050 --> 00:30:57,090 +الأعراب يعني مثلا Zero, no bleeding Number one, + +447 +00:30:57,230 --> 00:31:01,230 +minimal bleeding Spontaneous, self-limited تلاتة, + +448 +00:31:01,290 --> 00:31:04,470 +spontaneous, requiring local treatment أربعة, + +449 +00:31:04,570 --> 00:31:08,030 +spontaneous, uncontrolled or poorly controlled عسب + +450 +00:31:08,030 --> 00:31:10,810 +الـ deficiency في الـ Platelets فلقيت لو أجينا + +451 +00:31:10,810 --> 00:31:14,030 +مثلا في الـ Range هذا إحنا قولنا إنه الـ Platelet + +452 +00:31:14,030 --> 00:31:20,620 +من 150 لغاية 450 ألفالـ Bladlet لو كانت من لغاية + +453 +00:31:20,620 --> 00:31:27,400 +تقريبا نقول 60 عادة ما بيصيرش bleeding بنبدأ عند + +454 +00:31:27,400 --> 00:31:31,680 +الخمسين بيصير احتمالية minimal bleeding تمام؟ لو + +455 +00:31:31,680 --> 00:31:36,900 +نقصدت عندها تقريبا من العشرين والتلاتين ممكن يكون + +456 +00:31:36,900 --> 00:31:41,280 +spontaneous self-limited bleeding لو نزلت عن عشرين + +457 +00:31:41,280 --> 00:31:46,920 +ممكن تزيد ال severity وتحتاج لـ treatmentلو نقصت + +458 +00:31:46,920 --> 00:31:51,080 +عن عشرة هنلاحظ أنه هيصير عندنا «severe bleeding, + +459 +00:31:51,280 --> 00:31:54,180 +uncontrolled or poorly controlled» فبتتالي عدد + +460 +00:31:54,180 --> 00:31:58,440 +الصفائح يعني مش مجرد ما تنزل الصفائح عن 150 هيبدأ + +461 +00:31:58,440 --> 00:32:01,340 +يصير bleeding وإحنا نلاحظ يعني إحنا بنلاحظه لما + +462 +00:32:01,340 --> 00:32:04,140 +يكون فعلا نزلت تقريبا عن 50 أو عند 40 + +463 +00:32:10,140 --> 00:32:14,160 +طيب هنا بقولك انه bleeding time and bleeding احنا + +464 +00:32:14,160 --> 00:32:17,120 +فيه فحص ل bleeding time هو فحص مش دقيق بالمرة + +465 +00:32:17,120 --> 00:32:24,920 +بنعمل من خلاله نشوف وضع ال platelets طبعا خمسة إلى + +466 +00:32:24,920 --> 00:32:27,820 +عشرة في المية من المرضى بنعمللهم بيعطوني prolonged + +467 +00:32:27,820 --> 00:32:31,380 +bleeding time وعادة بيكون ال prolongation نتيجة + +468 +00:32:31,380 --> 00:32:33,780 +بعض ال drugs اللي ممكن يكون مخدها المريض زي + +469 +00:32:33,780 --> 00:32:39,110 +الأسبرين أو غيرهطبعاً يعني لو أنا لقيت ال bleeding + +470 +00:32:39,110 --> 00:32:43,350 +time عالي مش شرط أنه هذا الشخص لو دخل عملية ممكن + +471 +00:32:43,350 --> 00:32:46,370 +ينزف لأنه انتوا عارفين ال bleeding time لو كان + +472 +00:32:46,370 --> 00:32:49,530 +عالي بيكون خلل في البلاتلت وخلل في البلاتلت بيصير + +473 +00:32:49,530 --> 00:32:53,930 +نزف بسيط عند بداية العملية وبنتي فبالتالي مش فحص + +474 +00:32:53,930 --> 00:32:57,010 +دقيق بالمرة اللي أفضل منه البلاتلت aggregate + +475 +00:33:00,060 --> 00:33:03,600 +conclusion a special calculation is a specialized + +476 +00:33:03,600 --> 00:33:07,440 +complex and dynamic field هو يعني موضوع مش سهل + +477 +00:33:07,440 --> 00:33:13,800 +ومتشعب ومتجدد وبده بحث باستمرار ويعطيكوا الف عافية + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk_raw.json b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/W7XeDTI0iNk_raw.json new file mode 100644 index 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هنلاقي البلازمين ارتفع و قد إلى ارتفاع الـ fibrin degradation of products Intravascular clot تكون الـ clots في الـ blood vessels إيش هتعمل؟ هتنقص البلاتلتز هتعمل عندك testocyte من الحاجات المميزة للـ DIC وجود", "tokens": [41185, 2423, 39184, 739, 3548, 259, 565, 23758, 2423, 39184, 739, 3548, 259, 565, 31439, 4724, 8592, 1829, 9566, 15844, 2423, 39184, 283, 6414, 259, 8799, 1975, 43500, 5172, 45761, 3224, 4724, 25708, 1211, 15844, 14739, 2423, 39184, 283, 6414, 259, 8799, 9154, 9778, 5172, 11242, 2423, 39184, 283, 6414, 259, 8799, 8032, 1863, 15040, 38436, 3224, 20193, 8032, 1863, 15040, 38436, 29739, 1211, 31377, 2304, 9957, 1975, 43500, 5172, 3615, 4032, 12174, 3215, 30731, 1975, 43500, 5172, 45761, 2423, 39184, 283, 6414, 259, 40519, 295, 3383, 5681, 13404, 22084, 48587, 6055, 30544, 2423, 39184, 596, 1971, 8978, 2423, 39184, 3390, 20117, 11933, 1829, 8592, 8032, 2655, 25957, 1211, 22807, 8032, 2655, 1863, 4587, 9381, 29739, 1211, 9307, 1211, 2655, 11622, 8032, 2655, 25957, 1211, 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"word": " degradation", "probability": 0.9482421875}, {"start": 777.09, "end": 777.41, "word": " of", "probability": 0.39404296875}, {"start": 777.41, "end": 777.85, "word": " products", "probability": 0.53857421875}, {"start": 777.85, "end": 779.67, "word": " Intravascular", "probability": 0.7223307291666666}, {"start": 779.67, "end": 780.09, "word": " clot", "probability": 0.62841796875}, {"start": 780.09, "end": 780.59, "word": " تكون", "probability": 0.84619140625}, {"start": 780.59, "end": 780.85, "word": " الـ", "probability": 0.56005859375}, {"start": 780.85, "end": 781.13, "word": " clots", "probability": 0.785888671875}, {"start": 781.13, "end": 781.39, "word": " في", "probability": 0.9482421875}, {"start": 781.39, "end": 781.79, "word": " الـ", "probability": 0.730712890625}, {"start": 781.79, "end": 782.05, "word": " blood", "probability": 0.95947265625}, {"start": 782.05, "end": 782.45, "word": " vessels", "probability": 0.8681640625}, {"start": 782.45, "end": 782.85, "word": " إيش", "probability": 0.7347819010416666}, {"start": 782.85, "end": 783.49, "word": " هتعمل؟", "probability": 0.8994140625}, {"start": 783.49, "end": 784.01, "word": " هتنقص", "probability": 0.87421875}, {"start": 784.01, "end": 784.67, "word": " البلاتلتز", "probability": 0.6348470052083334}, {"start": 784.67, "end": 785.15, "word": " هتعمل", "probability": 0.85498046875}, {"start": 785.15, "end": 785.57, "word": " عندك", "probability": 0.4744873046875}, {"start": 785.57, "end": 786.47, "word": " testocyte", "probability": 0.5607096354166666}, {"start": 786.47, "end": 786.61, "word": " من", "probability": 0.92431640625}, {"start": 786.61, "end": 787.07, "word": " الحاجات", "probability": 0.9930013020833334}, {"start": 787.07, "end": 788.05, "word": " المميزة", "probability": 0.854638671875}, {"start": 788.05, "end": 788.23, "word": " للـ", "probability": 0.78515625}, {"start": 788.23, "end": 788.65, "word": " DIC", "probability": 0.7548828125}, {"start": 788.65, "end": 789.47, "word": " وجود", "probability": 0.972900390625}], "temperature": 1.0}, {"id": 29, "seek": 80389, "start": 791.03, "end": 803.89, "text": "طيب نيجي للـplatelet disorders الـplatelet disorders قد تكون quantitative أو qualitative ال quantitative قد تكون بسبب abnormal distribution يعني على سبيل المثال في مكان", "tokens": [9566, 1829, 3555, 8717, 1829, 7435, 1829, 24976, 39184, 39975, 15966, 20261, 2423, 39184, 39975, 15966, 20261, 12174, 3215, 6055, 30544, 27778, 34051, 31312, 2423, 27778, 12174, 3215, 6055, 30544, 4724, 35457, 3555, 32847, 7316, 37495, 22653, 15844, 8608, 21292, 1211, 9673, 12984, 6027, 8978, 3714, 41361], "avg_logprob": -0.16243490017950535, "compression_ratio": 1.4933333333333334, "no_speech_prob": 1.4901161193847656e-06, "words": [{"start": 791.03, "end": 791.41, "word": "طيب", "probability": 0.789794921875}, {"start": 791.41, "end": 791.83, "word": " نيجي", "probability": 0.9232177734375}, {"start": 791.83, "end": 792.49, "word": " للـplatelet", "probability": 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"probability": 0.74884033203125}, {"start": 1830.83, "end": 1830.99, "word": " ممكن", "probability": 0.914306640625}, {"start": 1830.99, "end": 1831.21, "word": " يكون", "probability": 0.986328125}, {"start": 1831.21, "end": 1831.55, "word": " عددها", "probability": 0.9837646484375}, {"start": 1831.55, "end": 1831.95, "word": " طبيعي", "probability": 0.9720458984375}, {"start": 1831.95, "end": 1832.21, "word": " بس", "probability": 0.994140625}, {"start": 1832.21, "end": 1832.41, "word": " هي", "probability": 0.86279296875}, {"start": 1832.41, "end": 1832.59, "word": " non", "probability": 0.92919921875}, {"start": 1832.59, "end": 1833.51, "word": "-functional", "probability": 0.83935546875}, {"start": 1833.51, "end": 1834.75, "word": " بعمل", "probability": 0.8636067708333334}, {"start": 1834.75, "end": 1835.05, "word": " bleeding", "probability": 0.92138671875}, {"start": 1835.05, "end": 1835.51, "word": " time", "probability": 0.8701171875}, {"start": 1835.51, "end": 1835.85, "word": " أو", "probability": 0.8740234375}, {"start": 1835.85, "end": 1836.41, "word": " bleeding", "probability": 0.5341796875}, {"start": 1836.41, "end": 1837.47, "word": " أو", "probability": 0.11907958984375}, {"start": 1837.47, "end": 1838.01, "word": " blatlet", "probability": 0.535888671875}, {"start": 1838.01, "end": 1838.75, "word": " aggregation", "probability": 0.949462890625}, {"start": 1838.75, "end": 1839.37, "word": " study", "probability": 0.974609375}, {"start": 1839.37, "end": 1840.67, "word": " هنا", "probability": 0.09124755859375}, {"start": 1840.67, "end": 1840.95, "word": " عندي", "probability": 0.591796875}, {"start": 1840.95, "end": 1841.23, "word": " رسم", "probability": 0.595458984375}, {"start": 1841.23, "end": 1841.77, "word": " بياني", "probability": 0.9798583984375}, {"start": 1841.77, "end": 1842.27, "word": " بيوضح", "probability": 0.86962890625}, {"start": 1842.27, "end": 1842.69, "word": " عندي", "probability": 0.952880859375}, {"start": 1842.69, 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spontaneous, requiring local treatment أربعة, spontaneous, uncontrolled or poorly controlled عسب الـ deficiency في الـ Platelets فلقيت لو أجينا مثلا في الـ Range هذا إحنا قولنا إنه الـ Platelet من 150 لغاية 450 ألف", "tokens": [40228, 22653, 4724, 39648, 4117, 14739, 3224, 50113, 15040, 34105, 2423, 39184, 17461, 15966, 1207, 4032, 34105, 11331, 3215, 3660, 16247, 3615, 2288, 16758, 37495, 22653, 50113, 15040, 17182, 11, 572, 19312, 5118, 472, 11, 13206, 19312, 1738, 896, 15447, 11, 2698, 12, 18692, 6055, 1211, 9307, 3660, 11, 32744, 11, 24165, 2654, 5032, 5551, 25513, 3615, 3660, 11, 32744, 11, 36019, 28850, 420, 22271, 10164, 6225, 35457, 2423, 39184, 37500, 8978, 2423, 39184, 17461, 37220, 6156, 1211, 4587, 36081, 45164, 5551, 7435, 1829, 8315, 50113, 15040, 8978, 2423, 39184, 33778, 23758, 11933, 5016, 8315, 12174, 12610, 8315, 36145, 3224, 2423, 39184, 17461, 15966, 9154, 8451, 5296, 17082, 995, 10632, 26034, 5551, 46538], "avg_logprob": -0.2809758633375168, "compression_ratio": 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1867.17, "word": " controlled", "probability": 0.70166015625}, {"start": 1867.17, "end": 1868.03, "word": " عسب", "probability": 0.664306640625}, {"start": 1868.03, "end": 1868.29, "word": " الـ", "probability": 0.805908203125}, {"start": 1868.29, "end": 1868.61, "word": " deficiency", "probability": 0.7158203125}, {"start": 1868.61, "end": 1868.89, "word": " في", "probability": 0.9326171875}, {"start": 1868.89, "end": 1869.05, "word": " الـ", "probability": 0.68115234375}, {"start": 1869.05, "end": 1869.43, "word": " Platelets", "probability": 0.679931640625}, {"start": 1869.43, "end": 1870.37, "word": " فلقيت", "probability": 0.660186767578125}, {"start": 1870.37, "end": 1870.53, "word": " لو", "probability": 0.97802734375}, {"start": 1870.53, "end": 1870.81, "word": " أجينا", "probability": 0.7623291015625}, {"start": 1870.81, "end": 1871.25, "word": " مثلا", "probability": 0.979248046875}, {"start": 1871.25, "end": 1871.59, "word": " في", "probability": 0.97216796875}, {"start": 1871.59, "end": 1871.69, "word": " الـ", "probability": 0.847412109375}, {"start": 1871.69, "end": 1871.93, "word": " Range", "probability": 0.533203125}, {"start": 1871.93, "end": 1872.33, "word": " هذا", "probability": 0.339111328125}, {"start": 1872.33, "end": 1872.93, "word": " إحنا", "probability": 0.7967122395833334}, {"start": 1872.93, "end": 1873.49, "word": " قولنا", "probability": 0.7724609375}, {"start": 1873.49, "end": 1873.69, "word": " إنه", "probability": 0.6019287109375}, {"start": 1873.69, "end": 1873.83, "word": " الـ", "probability": 0.72412109375}, {"start": 1873.83, "end": 1874.03, "word": " Platelet", "probability": 0.8427734375}, {"start": 1874.03, "end": 1874.19, "word": " من", "probability": 0.97314453125}, {"start": 1874.19, "end": 1874.73, "word": " 150", "probability": 0.9384765625}, {"start": 1874.73, "end": 1875.59, "word": " لغاية", "probability": 0.9591064453125}, {"start": 1875.59, "end": 1875.97, "word": " 450", "probability": 0.89697265625}, {"start": 1875.97, "end": 1876.67, "word": " ألف", "probability": 0.9013671875}], "temperature": 1.0}, {"id": 71, "seek": 190524, "start": 1877.22, "end": 1905.24, "text": "الـ Bladlet لو كانت من لغاية تقريبا نقول 60 عادة ما بيصيرش bleeding بنبدأ عند الخمسين بيصير احتمالية minimal bleeding تمام؟ لو نقصدت عندها تقريبا من العشرين والتلاتين ممكن يكون spontaneous self-limited bleeding لو نزلت عن عشرين ممكن تزيد ال severity وتحتاج لـ treatment", "tokens": [6027, 39184, 2177, 345, 2631, 45164, 25961, 2655, 9154, 5296, 17082, 995, 10632, 6055, 4587, 16572, 3555, 995, 8717, 39648, 4060, 6225, 18513, 3660, 19446, 4724, 1829, 9381, 13546, 8592, 19312, 44945, 44510, 10721, 43242, 33962, 2304, 3794, 9957, 4724, 1829, 9381, 13546, 1975, 33753, 2304, 6027, 10632, 13206, 19312, 46811, 10943, 22807, 45164, 8717, 4587, 9381, 3215, 2655, 43242, 11296, 6055, 4587, 16572, 3555, 995, 9154, 18863, 46309, 9957, 16070, 2655, 1211, 9307, 9957, 3714, 43020, 7251, 30544, 32744, 2698, 12, 18692, 19312, 45164, 8717, 11622, 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{"start": 1883.12, "end": 1884.36, "word": " عادة", "probability": 0.9752604166666666}, {"start": 1884.36, "end": 1884.48, "word": " ما", "probability": 0.70166015625}, {"start": 1884.48, "end": 1884.88, "word": " بيصيرش", "probability": 0.91845703125}, {"start": 1884.88, "end": 1885.22, "word": " bleeding", "probability": 0.94873046875}, {"start": 1885.22, "end": 1887.06, "word": " بنبدأ", "probability": 0.89208984375}, {"start": 1887.06, "end": 1887.4, "word": " عند", "probability": 0.98681640625}, {"start": 1887.4, "end": 1888.04, "word": " الخمسين", "probability": 0.84912109375}, {"start": 1888.04, "end": 1888.42, "word": " بيصير", "probability": 0.88671875}, {"start": 1888.42, "end": 1889.16, "word": " احتمالية", "probability": 0.98427734375}, {"start": 1889.16, "end": 1889.56, "word": " minimal", "probability": 0.76416015625}, {"start": 1889.56, "end": 1890.32, "word": " bleeding", "probability": 0.96826171875}, {"start": 1890.32, "end": 1891.46, "word": " تمام؟", "probability": 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"probability": 0.855712890625}, {"start": 1898.86, "end": 1899.54, "word": " bleeding", "probability": 0.95703125}, {"start": 1899.54, "end": 1900.14, "word": " لو", "probability": 0.9609375}, {"start": 1900.14, "end": 1900.54, "word": " نزلت", "probability": 0.993896484375}, {"start": 1900.54, "end": 1900.7, "word": " عن", "probability": 0.962890625}, {"start": 1900.7, "end": 1901.28, "word": " عشرين", "probability": 0.91650390625}, {"start": 1901.28, "end": 1901.82, "word": " ممكن", "probability": 0.9775390625}, {"start": 1901.82, "end": 1902.54, "word": " تزيد", "probability": 0.9754231770833334}, {"start": 1902.54, "end": 1902.7, "word": " ال", "probability": 0.8955078125}, {"start": 1902.7, "end": 1903.12, "word": " severity", "probability": 0.859375}, {"start": 1903.12, "end": 1904.48, "word": " وتحتاج", "probability": 0.9412434895833334}, {"start": 1904.48, "end": 1904.82, "word": " لـ", "probability": 0.65869140625}, {"start": 1904.82, "end": 1905.24, "word": " treatment", "probability": 0.6015625}], "temperature": 1.0}, {"id": 72, "seek": 192414, "start": 1905.84, "end": 1924.14, "text": "لو نقصت عن عشرة هنلاحظ أنه هيصير عندنا «severe bleeding, uncontrolled or poorly controlled» فبتتالي عدد الصفائح يعني مش مجرد ما تنزل الصفائح عن 150 هيبدأ يصير bleeding وإحنا نلاحظ يعني إحنا بنلاحظه لما يكون فعلا نزلت تقريبا عن 50 أو عند 40", "tokens": [1211, 2407, 8717, 4587, 9381, 2655, 18871, 6225, 8592, 25720, 8032, 1863, 15040, 5016, 19913, 14739, 3224, 39896, 9381, 13546, 43242, 8315, 4657, 405, 5887, 19312, 11, 36019, 28850, 420, 22271, 10164, 5933, 6156, 3555, 2655, 2655, 6027, 1829, 6225, 3215, 3215, 31767, 5172, 16373, 5016, 37495, 22653, 37893, 3714, 7435, 2288, 3215, 19446, 6055, 1863, 11622, 1211, 31767, 5172, 16373, 5016, 18871, 8451, 39896, 44510, 10721, 7251, 9381, 13546, 19312, 4032, 28814, 5016, 8315, 8717, 15040, 5016, 19913, 37495, 22653, 11933, 5016, 8315, 44945, 15040, 5016, 19913, 3224, 5296, 15042, 7251, 30544, 6156, 3615, 15040, 8717, 11622, 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" bleeding,", "probability": 0.94873046875}, {"start": 1911.28, "end": 1911.94, "word": " uncontrolled", "probability": 0.868896484375}, {"start": 1911.94, "end": 1912.24, "word": " or", "probability": 0.8408203125}, {"start": 1912.24, "end": 1912.88, "word": " poorly", "probability": 0.8828125}, {"start": 1912.88, "end": 1913.4, "word": " controlled»", "probability": 0.858154296875}, {"start": 1913.4, "end": 1913.92, "word": " فبتتالي", "probability": 0.8490397135416666}, {"start": 1913.92, "end": 1914.18, "word": " عدد", "probability": 0.8943684895833334}, {"start": 1914.18, "end": 1914.74, "word": " الصفائح", "probability": 0.989501953125}, {"start": 1914.74, "end": 1915.28, "word": " يعني", "probability": 0.79150390625}, {"start": 1915.28, "end": 1915.44, "word": " مش", "probability": 0.982421875}, {"start": 1915.44, "end": 1915.98, "word": " مجرد", "probability": 0.85614013671875}, {"start": 1915.98, "end": 1916.08, "word": " ما", "probability": 0.81494140625}, {"start": 1916.08, "end": 1916.52, "word": " تنزل", "probability": 0.9927978515625}, {"start": 1916.52, "end": 1917.1, "word": " الصفائح", "probability": 0.995849609375}, {"start": 1917.1, "end": 1917.28, "word": " عن", "probability": 0.92529296875}, {"start": 1917.28, "end": 1917.8, "word": " 150", "probability": 0.91650390625}, {"start": 1917.8, "end": 1918.44, "word": " هيبدأ", "probability": 0.7510579427083334}, {"start": 1918.44, "end": 1918.68, "word": " يصير", "probability": 0.9664713541666666}, {"start": 1918.68, "end": 1919.16, "word": " bleeding", "probability": 0.9013671875}, {"start": 1919.16, "end": 1919.88, "word": " وإحنا", "probability": 0.7447509765625}, {"start": 1919.88, "end": 1920.28, "word": " نلاحظ", "probability": 0.9793701171875}, {"start": 1920.28, "end": 1920.42, "word": " يعني", "probability": 0.7215576171875}, {"start": 1920.42, "end": 1920.64, "word": " إحنا", "probability": 0.9210611979166666}, {"start": 1920.64, "end": 1921.2, "word": " بنلاحظه", "probability": 0.95908203125}, {"start": 1921.2, "end": 1921.34, "word": " لما", "probability": 0.948486328125}, {"start": 1921.34, "end": 1921.66, "word": " يكون", "probability": 0.964599609375}, {"start": 1921.66, "end": 1922.04, "word": " فعلا", "probability": 0.7262369791666666}, {"start": 1922.04, "end": 1922.44, "word": " نزلت", "probability": 0.982666015625}, {"start": 1922.44, "end": 1922.88, "word": " تقريبا", "probability": 0.97265625}, {"start": 1922.88, "end": 1923.02, "word": " عن", "probability": 0.9697265625}, {"start": 1923.02, "end": 1923.38, "word": " 50", "probability": 0.9091796875}, {"start": 1923.38, "end": 1923.56, "word": " أو", "probability": 0.95361328125}, {"start": 1923.56, "end": 1923.8, "word": " عند", "probability": 0.455078125}, {"start": 1923.8, "end": 1924.14, "word": " 40", "probability": 0.98486328125}], "temperature": 1.0}, {"id": 73, "seek": 195486, "start": 1930.14, "end": 1954.86, "text": "طيب هنا بقولك انه bleeding time and bleeding احنا فيه فحص ل bleeding 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+00:00:17,020 --> 00:00:21,040 +bleeding disorders ناخد فكرة عنها و نشوف كيف بدنا + +3 +00:00:21,040 --> 00:00:27,080 +نعمل لها diagnosis و نفرقها عن بعض المشاكل + +4 +00:00:27,080 --> 00:00:32,000 +اللي ممكن تصير في ال bleeding قد تكون جاية من خلل + +5 +00:00:32,000 --> 00:00:36,100 +في ال coagulation factors أو خلل في ال platelets + +6 +00:00:36,100 --> 00:00:43,000 +خلينا نعمل مقارنة بسيطة بينهم بين الأعراضبداية + +7 +00:00:43,000 --> 00:00:46,020 +البلاتلات الـ disorders و الـ coagulation + +8 +00:00:46,020 --> 00:00:50,940 +disorders نشوف أول حاجة الـ site of bleeding عادة + +9 +00:00:50,940 --> 00:00:55,360 +البلاتلات الـ disorders بتبقى الأماكن اللي بيصير + +10 +00:00:55,360 --> 00:00:59,900 +فيها ال bleeding عادة سطحية يعني في ال skin، في ال + +11 +00:00:59,900 --> 00:01:06,920 +mucous membrane زي ابستاكسز، gum، vaginal، GIT، + +12 +00:01:06,920 --> 00:01:10,400 +bleeding يعني في أماكن وين في ميوكاس membrane أو + +13 +00:01:10,400 --> 00:01:13,620 +skin ممكن تظهربينما الـ Coagulation Factor + +14 +00:01:13,620 --> 00:01:16,800 +Disorders بتكون في أماكن عميقة زي الـ joints و ال + +15 +00:01:16,800 --> 00:01:21,680 +muscles بالتاكية في الـ Platelet Disorder بتكون + +16 +00:01:21,680 --> 00:01:25,580 +واضحة بينما في الـ Coagulation Factor Disorders لأ + +17 +00:01:25,580 --> 00:01:30,740 +الـ Echemosis اللي هي الكدمات الذرقاء الكبيرة عادة + +18 +00:01:30,740 --> 00:01:34,560 +يعني في الـ Platelets بتكون صغيرة و superficial + +19 +00:01:34,560 --> 00:01:38,560 +بينما في الـ Coagulation Factor Disorders بتكون + +20 +00:01:38,560 --> 00:01:43,230 +large and deepHemarthrosis أو Muscle bleeding اللي + +21 +00:01:43,230 --> 00:01:47,390 +هو تجمع دموي في المفاصل أو في العضلات في + +22 +00:01:47,390 --> 00:01:50,510 +الـplatelet disorder extremely rare بينما في + +23 +00:01:50,510 --> 00:01:54,710 +الـcoagulation factor أساسي bleeding after cut or + +24 +00:01:54,710 --> 00:01:59,590 +scratches عادة الجروح السطحية البسيطة لو كان في + +25 +00:01:59,590 --> 00:02:03,670 +platelet disorder بتظل تنزف بينما في + +26 +00:02:03,670 --> 00:02:06,470 +الـcoagulation factor disorders عادة ما بيصيرش + +27 +00:02:06,470 --> 00:02:10,640 +منها مشاكلالـ bleeding after surgery or trauma + +28 +00:02:10,640 --> 00:02:16,480 +عادة بيكون immediate bleeding وبيكون يعني خفيف + +29 +00:02:16,480 --> 00:02:21,960 +مابيكونش كتير بينما بعد العمليات الجراحية إذا كان + +30 +00:02:21,960 --> 00:02:25,560 +فيه خلل في ال coagulation factor بيصير ال bleeding + +31 +00:02:25,560 --> 00:02:31,160 +متأخر يعني مابيصيرش في الحال ومن يوم إلى يومين بعد + +32 +00:02:31,160 --> 00:02:35,260 +العملية وعادة بيكون severe بيكون صعب ومضاعفات + +33 +00:02:35,260 --> 00:02:35,680 +خاطرة + +34 +00:02:38,940 --> 00:02:43,360 +من الـ Coagulation Factor Disorders نوعين نوع + +35 +00:02:43,360 --> 00:02:47,420 +Inherited و نوع Acquired الـ Inherited زي اللي + +36 +00:02:47,420 --> 00:02:51,720 +احنا عارفينهم بشكل عام الـ Factor Deficiencies من + +37 +00:02:51,720 --> 00:02:55,800 +الـ Factor Deficiencies الاكتر شيوعان Hemophilia A + +38 +00:02:55,800 --> 00:03:00,940 +و Hemophilia B في عندي الـ Vinyl Brand Disease في + +39 +00:03:00,940 --> 00:03:04,520 +عندي Acquired Disorders زي Liver Disease و Vitamin + +40 +00:03:04,520 --> 00:03:09,640 +K Deficiency أو الناس اللي بتاخد وفرينOverdose + +41 +00:03:09,640 --> 00:03:18,560 +يعني أخدت وافرين كمية كبيرة حالات الـ DIC طيب + +42 +00:03:18,560 --> 00:03:22,360 +نيجي مقارنة بسيطة بين Hemophilia A و Hemophilia B + +43 +00:03:22,360 --> 00:03:26,120 +زي ما احنا عارفين Hemophilia A بيكون خلل في factor + +44 +00:03:26,120 --> 00:03:30,760 +8 Hemophilia B بيبقى فيه خلل أو نقص في factor 9 + +45 +00:03:30,760 --> 00:03:37,180 +طريق التوريث كلاهما X-linked recessive ال + +46 +00:03:37,180 --> 00:03:43,130 +incidenceHemophilia A 1 على 10 ألف Hemophilia B 1 + +47 +00:03:43,130 --> 00:03:47,770 +على 50 ألف Male يعني هذه أقل شيوعاً اللي هي + +48 +00:03:47,770 --> 00:03:54,170 +Hemophilia B Severity طبعاً بترجع لقداش صار + +49 +00:03:54,170 --> 00:03:59,110 +deficiency في ال factor إذا كانت كمية ال factor + +50 +00:03:59,110 --> 00:04:03,430 +الموجودة أقل من 1% هتلاقي severe spontaneous + +51 +00:04:03,430 --> 00:04:07,280 +bleedingلو كانت كمية الـ Factor الموجودة من 1 إلى + +52 +00:04:07,280 --> 00:04:12,260 +5% مدرات bleeding with mild injury مع الجروح + +53 +00:04:12,260 --> 00:04:17,840 +البسيطة ممكن يصير bleeding من 5 إلى 25% mild + +54 +00:04:17,840 --> 00:04:20,680 +bleeding with surgery or trauma بس يعني بيصير + +55 +00:04:20,680 --> 00:04:24,920 +bleeding خفيف مع الضربات الكبيرة أو مع حدوث عمليات + +56 +00:04:24,920 --> 00:04:28,960 +جراحية الـ Complications عادة it and then بيصير + +57 +00:04:28,960 --> 00:04:34,580 +لهم complications إنه بيصير soft shock bleedingطيب + +58 +00:04:34,580 --> 00:04:38,800 +الـ hemophilia الـ clinical manifestations طبعاً A + +59 +00:04:38,800 --> 00:04:44,440 +and B بالأعراض صعب أنه أفرقهم لازم أعمل factor الـ + +60 +00:04:44,440 --> 00:04:48,880 +C عشان أعرف المشكلة وين أول حاجة hemarthrosis + +61 +00:04:48,880 --> 00:04:52,660 +بيصير تجمع دموي في المفاصل نتيجة حركة المفاصل + +62 +00:04:52,660 --> 00:04:58,260 +بيصير زي تمزق في blood vessels هذا التمزق بينشأ + +63 +00:04:58,260 --> 00:05:03,220 +عنه bleeding يؤدي إلى تجمع blood في المفصلفبتحول + +64 +00:05:03,220 --> 00:05:07,480 +المفصل كإنه fixed joint يعني المفصل هذا صعب يتحرك + +65 +00:05:07,480 --> 00:05:12,380 +soft tissue hematoma تجمعات دموية في ال soft + +66 +00:05:12,380 --> 00:05:16,500 +tissue زي ال muscles ممكن هذا يؤدي لمuscle atrophy + +67 +00:05:16,500 --> 00:05:22,800 +أو shortened tendons other sites of bleeding زي ال + +68 +00:05:22,800 --> 00:05:26,350 +urinary tract و ال central nervous systemneck may + +69 +00:05:26,350 --> 00:05:30,510 +be life threatening ممكن يصير نزيف العنف ويكون + +70 +00:05:30,510 --> 00:05:34,290 +خطير prolonged bleeding after surgery or dental + +71 +00:05:34,290 --> 00:05:37,710 +extraction يعني عادة هدول لما بيروحوا بيخلعوا + +72 +00:05:37,710 --> 00:05:42,310 +أسنانهم أو بيعملوا عمليات يعني حاجات في الفم أو + +73 +00:05:42,310 --> 00:05:50,390 +عمليات جراحية بسيطة هيصير عندهم bleeding ويطول هذا + +74 +00:05:50,390 --> 00:05:54,870 +منظر للـ hemarthrosis كيف تجمع دموي في المفصل + +75 +00:05:55,170 --> 00:05:59,070 +بيقدّي الانتفاخ المفصل لو أخلنا عينة من الـ + +76 +00:05:59,070 --> 00:06:02,370 +Synovial Fluid هنلاقي بلدي هنلاقي كمية ال blood + +77 +00:06:02,370 --> 00:06:06,450 +فيه كبيرة كبيرة + +78 +00:06:06,450 --> 00:06:11,010 +نيجي للـ Von Willebrand Disease الـ Von Willebrand + +79 +00:06:11,010 --> 00:06:14,050 +Disease طبعا عبارة عن مرض من الأمراض الهيمستاسز + +80 +00:06:14,050 --> 00:06:17,050 +احنا عارفين الـ Von Willebrand Factor بتصنع في الـ + +81 +00:06:17,050 --> 00:06:21,290 +Endothelium وفي الـ Platelets عادة بتصنع على شكل + +82 +00:06:21,290 --> 00:06:26,020 +مونومر و بيصير له polymerizationفي الـ Endoplasmic + +83 +00:06:26,020 --> 00:06:30,980 +reticulum للخلايا وفي الجولجيابريتاس + +84 +00:06:30,980 --> 00:06:36,720 +وبيكون Large Multimer طبعا وظائفه هو يعتبر كـ + +85 +00:06:36,720 --> 00:06:40,240 +Carrier لـ Factor 8 الشغلة التانية المهمة اللي هي + +86 +00:06:40,240 --> 00:06:43,660 +بيثبت البلاتلت على الـ Subendothelium في بداية + +87 +00:06:43,660 --> 00:06:47,160 +مرحلة الـ Platelet Activation وبيعمل Bridging ما + +88 +00:06:47,160 --> 00:06:52,740 +بين البلاتلتبتم توريثه كـ Autosomal Dominant يعني + +89 +00:06:52,740 --> 00:06:56,300 +مالهوش علاقة بالـ X-Promosome زي حالات الهيموفيليا + +90 +00:06:56,300 --> 00:07:03,060 +Autosomal Dominant Incidence من 1 إلى 10 ألف من + +91 +00:07:03,060 --> 00:07:08,000 +الـ Clinical Features تبعها نيجي نشوف إيش الفحصات + +92 +00:07:08,000 --> 00:07:11,580 +اللي بتنعمل للـ Von Willebrand Disease أول إيش هي + +93 +00:07:11,580 --> 00:07:16,310 +الـ Von Willebrand Diseaseاللي قد يكون فيه اختلاف + +94 +00:07:16,310 --> 00:07:19,690 +كمي وقد يكون qualitative يعني قد يكون quantitative + +95 +00:07:19,690 --> 00:07:23,710 +deficiency أو qualitative deficiency هو صحيح تلت + +96 +00:07:23,710 --> 00:07:27,670 +أنواع نوعه type 1 بيكون في عندنا quantitative + +97 +00:07:27,670 --> 00:07:30,510 +deficiency لكن مش completely يعني فيه partial + +98 +00:07:30,510 --> 00:07:34,530 +deficiency type 2 qualitative deficiency يعني أنه + +99 +00:07:34,530 --> 00:07:37,930 +الـantigen موجود أو الـvolume brand factor موجود + +100 +00:07:37,930 --> 00:07:43,110 +لكن مابيشتغلش بالشكل الجيء الصحيحType 3 Totally + +101 +00:07:43,110 --> 00:07:47,970 +Quantitative Deficiency أنه هو نفسه مش موجود في + +102 +00:07:47,970 --> 00:07:52,150 +مشكلة فيه تصنيعه نشوف إيش الفحصات اللي ممكن تنعمل + +103 +00:07:52,150 --> 00:07:55,750 +في فحصات بتبحث عنه كـ Antigen يعني هل هو موجود أو + +104 +00:07:55,750 --> 00:08:00,590 +مش موجود بغض النظر عن وظيفة في عندنا فحصات بتشوف + +105 +00:08:00,590 --> 00:08:04,530 +الـ Activity في عندنا الـ Multimarket Analysis أول + +106 +00:08:04,530 --> 00:08:08,610 +إشي الـ Vanwill Brand Antigen أكيد هو هيكون موجود + +107 +00:08:09,330 --> 00:08:13,150 +في الحالة الأولى لكن فيه deficiency الحالة التانية + +108 +00:08:13,150 --> 00:08:15,850 +هيكون normal ليش؟ لأن مافيش عندي مشكلة في الـ + +109 +00:08:15,850 --> 00:08:18,190 +Antigen قى Antigen لكن عندي مشكلة في الوظيفة + +110 +00:08:18,190 --> 00:08:21,930 +الحالة التالتة هيكون فيه severe deficiency ليش؟ + +111 +00:08:21,930 --> 00:08:25,920 +لأن في عندي total quantitative deficiencyطيب، نيجي + +112 +00:08:25,920 --> 00:08:29,780 +للـ Activity الـ Activity الحالة الأولى هيكون فيه + +113 +00:08:29,780 --> 00:08:32,500 +نقص في الـ Activity الحالة التانية نقص في الـ + +114 +00:08:32,500 --> 00:08:34,840 +Activity لأنه فعليا المشكلة عندنا مش في الـ + +115 +00:08:34,840 --> 00:08:37,820 +Antigen في التانية في type 2 المشكلة عندنا في الـ + +116 +00:08:37,820 --> 00:08:41,960 +Activity زي ما حكينا الحالة التالتة تقريبا هيكون + +117 +00:08:41,960 --> 00:08:46,500 +الـ Activity قليلة جدا لأن ال factor أصلا مش موجود + +118 +00:08:46,500 --> 00:08:50,660 +نيجي لـ Multimer Analysis الـ Multimer Analysis + +119 +00:08:50,660 --> 00:08:54,040 +يعني هذه بتدل على إنه هل فعلا تكون بالشكل الصحيح + +120 +00:08:54,040 --> 00:08:58,840 +وكوّنالـ Polymers اللي إحنا عارفينها إحنا حكينا + +121 +00:08:58,840 --> 00:09:02,820 +إنه بتكون كم نمر وبعدين بيستكون الملتمر الحالتين + +122 +00:09:02,820 --> 00:09:06,820 +الأولانية مافيش فيه مشكلة يعني هيكون الملتمر موجود + +123 +00:09:06,820 --> 00:09:10,960 +ومافيش فيه مشكلة في type 1 وtype 2 بينما في type 3 + +124 +00:09:10,960 --> 00:09:15,560 +هيكون absent لأنه أصلا الـVar والـBrand فاكتر طيب + +125 +00:09:15,560 --> 00:09:22,410 +نيجي للـVitamin K deficiency الـVitamin Kطبعا الـ + +126 +00:09:22,410 --> 00:09:24,970 +Vitamin K بيجينا من الـ Green Vegetables بعدين + +127 +00:09:24,970 --> 00:09:28,350 +بيصيرله synthesis عن طريق الـ Intestinal Flora + +128 +00:09:28,350 --> 00:09:34,070 +مطلوب الـ Vitamin K لتصنيع اللي هو factor 2 و7 و9 + +129 +00:09:34,070 --> 00:09:39,410 +و10 ومطلوب برضه لبروتين C وبروتين S إيش أسباب الـ + +130 +00:09:39,410 --> 00:09:43,570 +deficiency؟ قد يكون Malnutrition أو Biliary + +131 +00:09:43,570 --> 00:09:47,590 +Obstruction أو Malabsorption أو بعض الـ Antibiotic + +132 +00:09:47,590 --> 00:09:54,230 +Therapyعلاجه ممكن ينعطى Vitamin K أو ينعطى Fresh + +133 +00:09:54,230 --> 00:10:01,630 +Frozen Plasma الآن + +134 +00:10:01,630 --> 00:10:06,170 +نيجي للـDisseminated Intravascular Coagulation + +135 +00:10:06,170 --> 00:10:10,270 +طبعا هذا يعتبر من الحالات الخطيرة والصعبة في أمراض + +136 +00:10:10,270 --> 00:10:14,830 +الـHemostasis بينتج عن activation of both + +137 +00:10:14,830 --> 00:10:18,810 +coagulation and fibrinolysisمن الحلات اللي ممكن + +138 +00:10:18,810 --> 00:10:25,170 +تعملوا triggering زي حلات sepsis حلات لـ trauma زي + +139 +00:10:25,170 --> 00:10:28,470 +الـ head injury و الـ fat embolism حلات الـ + +140 +00:10:28,470 --> 00:10:32,170 +malignancy obstetrical complications اللي هي بتصير + +141 +00:10:32,170 --> 00:10:36,510 +مضاعفات اللي ممكن تصير في الحمل أو عند الولادة زي + +142 +00:10:36,510 --> 00:10:40,690 +حلات الـ amniotic fluid embolism زي حلات الـ + +143 +00:10:40,690 --> 00:10:45,650 +Arreptio placenta اللي هي انفصال المشيمة حلات الـ + +144 +00:10:45,650 --> 00:10:51,410 +vascular disordersReaction to toxins عادة يحصل عند + +145 +00:10:51,410 --> 00:10:55,650 +لدغات الأفاعي والعقارب Snake venom أو بعض ال drugs + +146 +00:10:55,650 --> 00:10:58,890 +بعض ال immunological disorders زي الـ severe + +147 +00:10:58,890 --> 00:11:02,350 +allergic reaction أو الـ Transplant rejection كل + +148 +00:11:02,350 --> 00:11:07,190 +هذه حالات ممكن تعمل Triggering الـ Disseminated + +149 +00:11:07,190 --> 00:11:11,090 +Intravascular Coagulation Mechanism طبعاً حيصير + +150 +00:11:11,090 --> 00:11:14,610 +Systemic Activation of Coagulation حالات لما بيصير + +151 +00:11:14,610 --> 00:11:18,450 +Activation للـ Coagulationهيبدأ يتكون الفيبرين + +152 +00:11:18,450 --> 00:11:22,290 +الفيبرين هيبدأ يترسّب Intravascular هيترسّب بداخل + +153 +00:11:22,290 --> 00:11:25,970 +الـ blood vessels هذا رح يؤدي إلى انسداد بعض الـ + +154 +00:11:25,970 --> 00:11:30,970 +blood vessels الصغيرة و الحجمها متوسط و هيؤدي إلى + +155 +00:11:30,970 --> 00:11:34,130 +organ failure يعني لما يصير تسليط لـ blood vessel + +156 +00:11:34,130 --> 00:11:38,010 +بغض أورجان معين هذا الـ organ رح يصير فيه failure + +157 +00:11:38,010 --> 00:11:41,490 +شغلة تانية هيصير Depletion of platelets and + +158 +00:11:41,490 --> 00:11:45,060 +coagulation factor لأنه هيصير استهلاك لإلهموهذا رح + +159 +00:11:45,060 --> 00:11:50,800 +يؤدي إلى bleeding هنا + +160 +00:11:50,800 --> 00:11:55,120 +برضه بيوضح الكلام بشكل أفضل ال pathogenesis of DIC + +161 +00:11:55,120 --> 00:11:59,640 +طبعا بيصير release لبعض الأشياء اللي بتحفز ال + +162 +00:11:59,640 --> 00:12:02,720 +coagulation اللي هي thromboplastic material في ال + +163 +00:12:02,720 --> 00:12:06,520 +circulation للأسباب اللي حكيناها قبلها فبتتنشط + +164 +00:12:06,520 --> 00:12:10,220 +عملية ال coagulation ال coagulation هيحول لثرمبين + +165 +00:12:10,220 --> 00:12:13,500 +فيها في النهاية الفيبرينوجين إلى فيبرينطبعا طالما + +166 +00:12:13,500 --> 00:12:17,820 +اتكون الـ Fibrin هيتنشط عملية الـ Fibrinolysis عن + +167 +00:12:17,820 --> 00:12:21,960 +طريق طبعا البلازمينوشين بتحول لبلازمين أو بيبدأ + +168 +00:12:21,960 --> 00:12:25,820 +يعمل degradation للـ Fibrin طبعا هذا هيقدّي إلى + +169 +00:12:25,820 --> 00:12:30,040 +زيادة برضه الـ D-dimer والـ Fibrin degradation + +170 +00:12:30,040 --> 00:12:34,340 +الproducts هنشوف إيش هيصير، هيصير استهلاك للـ + +171 +00:12:34,340 --> 00:12:39,020 +coagulation factors زي هنلاحظ في ارتفاع في الـ BTT + +172 +00:12:40,470 --> 00:12:43,590 +في الـ thrombin time هذا الـ thrombin time هو بشيط + +173 +00:12:43,590 --> 00:12:47,010 +على الـ fibrinogen ارتفاعه بيدل على أن الـ + +174 +00:12:47,010 --> 00:12:51,650 +fibrinogen منخفض الـ fibrinogen هنلاقيه لا هنلاقي + +175 +00:12:51,650 --> 00:12:56,630 +البلازمين ارتفع و قد إلى ارتفاع الـ fibrin + +176 +00:12:56,630 --> 00:13:00,590 +degradation of products Intravascular clot تكون + +177 +00:13:00,590 --> 00:13:04,010 +الـ clots في الـ blood vessels إيش هتعمل؟ هتنقص + +178 +00:13:04,010 --> 00:13:08,050 +البلاتلتز هتعمل عندك testocyte من الحاجات المميزة + +179 +00:13:08,050 --> 00:13:13,230 +للـ DIC وجودطيب نيجي للـplatelet disorders + +180 +00:13:13,230 --> 00:13:16,450 +الـplatelet disorders قد تكون quantitative أو + +181 +00:13:16,450 --> 00:13:20,830 +qualitative ال quantitative قد تكون بسبب abnormal + +182 +00:13:20,830 --> 00:13:25,820 +distribution يعني على سبيل المثال في مكانبقول + +183 +00:13:25,820 --> 00:13:29,980 +نفترض مثلا فيه Hepatosplenomegaly لو كان في حالة + +184 +00:13:29,980 --> 00:13:32,340 +Hepatosplenomegaly هتلاقي فيه تجمع كبير + +185 +00:13:32,340 --> 00:13:35,980 +للـplatelets في الـspleen وفي الـliver فهذا هيؤدي + +186 +00:13:35,980 --> 00:13:39,460 +إلى نقصها في الـcirculation فهذا مقصود بمعنى + +187 +00:13:39,460 --> 00:13:44,080 +الـabnormal distribution dilution effect decreased + +188 +00:13:44,080 --> 00:13:47,260 +production increased destruction يعني هذه الحاجات + +189 +00:13:47,260 --> 00:13:51,050 +اللي ممكن تؤدي إلى نقص للـplateletsEqualitative + +190 +00:13:51,050 --> 00:13:55,650 +disorders قد تكون inherited وهي نادرة يعني في أنها + +191 +00:13:55,650 --> 00:13:58,990 +مشكلة في وظيفة الـplatelets نفسها وقد تكون + +192 +00:13:58,990 --> 00:14:02,830 +acquired بسبب medications أو chronic renal failure + +193 +00:14:02,830 --> 00:14:06,770 +أو cardio pulmonary bypass عارفين إيش يعني cardio + +194 +00:14:06,770 --> 00:14:10,030 +pulmonary bypass اللي هو لما بيعملوا عمليات القلب + +195 +00:14:10,030 --> 00:14:13,850 +مفتوح بيحطوا جهاز يقوم بدور القلب والرئتين خلال + +196 +00:14:13,850 --> 00:14:14,930 +إجراء العملية + +197 +00:14:18,960 --> 00:14:23,100 +خلّينا الآن نبدأ نشوف كيف بدنا نعمل lab evaluation + +198 +00:14:23,100 --> 00:14:28,540 +لل bleeding disorders أول حاجة ال CBC و البلد + +199 +00:14:28,540 --> 00:14:31,920 +السمير طبعا ال CBC و البلد السمير هيفيدوني في + +200 +00:14:31,920 --> 00:14:35,360 +موضوع البلاتلت يعني بشوف من خلالهم البلاتلت count + +201 +00:14:35,360 --> 00:14:40,760 +إذا كان فيه thrombocytopenia بشوف من خلالهم زي + +202 +00:14:40,760 --> 00:14:44,220 +حالات ال TTB اللي هي thrombocytopenic hyperborea + +203 +00:14:44,220 --> 00:14:47,420 +إذا كان فيه مثلا schistocyte ممكن يدل على إنه فيه + +204 +00:14:47,420 --> 00:14:51,120 +DIC and so onفبالتالي الـ Blood Smear بنشوف من + +205 +00:14:51,120 --> 00:14:54,020 +خلالها Blatulate Count RBCs and Blatulate + +206 +00:14:54,020 --> 00:14:57,380 +Warfology يعني بتفيدني بس في الموضوع الـ Blatulate + +207 +00:14:57,380 --> 00:15:03,100 +إلى حد ما يعني في الـ DIC بشوف Shistocyte طيب الـ + +208 +00:15:03,100 --> 00:15:06,140 +Coagulation Profile فحصات الـ Coagulation اللي + +209 +00:15:06,140 --> 00:15:09,960 +هنعملها الـ Prothrombin Time للـ Extrinsic Pathway + +210 +00:15:09,960 --> 00:15:14,380 +BTT للـ Intrinsic Pathway Coagulation Factor Assay + +211 +00:15:14,380 --> 00:15:17,000 +عشان نعرف بعض الـ Factors إذا كان فيها Difficiency + +212 +00:15:17,640 --> 00:15:21,780 +الـ Mixing Study 50 إلى 50 هنشوف إذا كان فيه + +213 +00:15:21,780 --> 00:15:25,880 +Inhibitors الـ Fibrinogen Assay عشان نشوف الـ + +214 +00:15:25,880 --> 00:15:28,740 +Level للـ Fibrinogen الـ Thrombin Time طبعاً بدل + +215 +00:15:28,740 --> 00:15:33,340 +على إذا كان في عندي مشكلة في الـ Fibrinogen الـ + +216 +00:15:33,340 --> 00:15:36,060 +Fibrinogen Defect قد يكون qualitative أو + +217 +00:15:36,060 --> 00:15:39,860 +quantitativeFibrin degradation in products or D + +218 +00:15:39,860 --> 00:15:43,600 +-dimer كل هذه الأشياء ممكن نعملها راح ناخدها بشيء + +219 +00:15:43,600 --> 00:15:46,390 +من التفصيل الـ Platelet Functionمن ضمن الأشياء + +220 +00:15:46,390 --> 00:15:48,770 +اللي ممكن تنعملها وظيفة الـ Platelet الـ Funnel + +221 +00:15:48,770 --> 00:15:52,190 +Brand Factor، bleeding time، Platelet Function + +222 +00:15:52,190 --> 00:15:59,950 +Analyzer، Platelet الآن بدنا ناخد مع بعض مرور سريع + +223 +00:15:59,950 --> 00:16:04,290 +على فحوصات الهيمостاسيز وكيف أنا بستخدمها في ال + +224 +00:16:04,290 --> 00:16:09,750 +diagnosis للحالات المرضية الآن لو أجى مريض عنده أو + +225 +00:16:09,750 --> 00:16:14,650 +بيعاني من bleedingهذا المريض أكيد راح يطلبله + +226 +00:16:14,650 --> 00:16:18,890 +الدكتور CPC بعد السؤول ومع الـ CPC حيطلبله الـ + +227 +00:16:18,890 --> 00:16:22,230 +Coagulation Profile إيش حيطلبله بالظبط؟ حيطلبله + +228 +00:16:22,230 --> 00:16:26,290 +غالبا Bt و Btt أول حاجة زي ما اتفقنا إن الـ Btt + +229 +00:16:26,290 --> 00:16:29,510 +بيشيك على الـ Intrinsic Pathway و الـ Common + +230 +00:16:29,510 --> 00:16:33,430 +Pathway لعند الفيبرينجين و الـ Prothrombin Time + +231 +00:16:33,430 --> 00:16:36,550 +حيشيك على ال Extrinsic Pathway و الCommon Pathway + +232 +00:16:36,550 --> 00:16:39,570 +برضه لعند الفيبرينجين يعني هدول ما حيشيكوا على + +233 +00:16:39,570 --> 00:16:43,700 +الفيبرينجينعندي فحص ثاني بشيك على الـ fibrinogen + +234 +00:16:43,700 --> 00:16:47,120 +اللي هو الـ thrombin time إذا كان الـ thrombin + +235 +00:16:47,120 --> 00:16:50,360 +time prolonged معنى الكلام أن الـ fibrinogen فيه + +236 +00:16:50,360 --> 00:16:54,120 +deficiency فبنروح بنعمل assay للـ fibrinogen و + +237 +00:16:54,120 --> 00:16:58,180 +بنحدد قيمته تمام؟ إذا هدول تقريبا التلات فحصات + +238 +00:16:58,180 --> 00:17:02,600 +الرئيسية في ال .. في ال .. في ال coagulation + +239 +00:17:02,600 --> 00:17:07,950 +profileهنا بناقش معانا بعض الـ Technical Errors + +240 +00:17:07,950 --> 00:17:10,750 +يعني احنا أخدناها بالتفصيل في مادة النزف العملي + +241 +00:17:10,750 --> 00:17:15,410 +اللي هو موضوع الـ Sodium Citrate اللي أنا استخدمته + +242 +00:17:15,410 --> 00:17:17,350 +طبعا احنا بنستخدم الـ Sodium Citrate كـ + +243 +00:17:17,350 --> 00:17:20,330 +Anticoagulant هل الـ Sodium Citrate كانت كميته + +244 +00:17:20,330 --> 00:17:23,830 +متناسبة مع كمية الـ Blood لأنه لو ماكانش فيه تناسب + +245 +00:17:23,830 --> 00:17:27,330 +سواء بزيادة أو بنقصان هيعمل prolongation للـ Time + +246 +00:17:27,330 --> 00:17:31,930 +مثلا صار تسرب للـ Sodium Citrate من القبوبة تلال + +247 +00:17:31,930 --> 00:17:36,510 +عملية السحب لو صار عندي مشاكل أنا سحبت ببطءلو عملت + +248 +00:17:36,510 --> 00:17:39,910 +label غلط، لو عملت checking مش بشكل صحيح، لو صار + +249 +00:17:39,910 --> 00:17:42,970 +heparin-contamination للعينة، لو كنت أنا بسحب من + +250 +00:17:42,970 --> 00:17:47,590 +Travenous line، ممكن كل هذه الأشياء أتأثر على + +251 +00:17:47,590 --> 00:17:52,390 +نتائج تبعتي أسباب تانية، biological factors، زي + +252 +00:17:52,390 --> 00:17:54,690 +مثلا الـHematocrit، إذا كنتوا فاكرين إذا كان + +253 +00:17:54,690 --> 00:17:57,430 +الـHematocrit مرتفع كتير أو منخفض كتير، لازم أنا + +254 +00:17:57,430 --> 00:18:01,530 +أعمله correction عشان أحسب كمية الصدر، كمسترات + +255 +00:18:01,530 --> 00:18:06,150 +المناسبة في كل حالةلو كان فيه ليبيميا مثلا في + +256 +00:18:06,150 --> 00:18:09,210 +العينة أو ارتفاع في الـ bilirubin كلها هذه أشياء + +257 +00:18:09,210 --> 00:18:14,690 +بتأثر على النتيجة بعندي أشياء برضه أخرى زي لو أنا + +258 +00:18:14,690 --> 00:18:18,550 +طولت على العينة في عندي labile factors حتتأثر لو + +259 +00:18:18,550 --> 00:18:21,150 +طولت ال incubation في ال 37 برضه هيأثر على ال + +260 +00:18:21,150 --> 00:18:25,590 +labile factors لو أنا خلال ما فرزتش العينة لو أنا + +261 +00:18:25,590 --> 00:18:29,330 +بدي افرزها و جيت فرزتها و دوبتها مش مش مش مش مش مش + +262 +00:18:29,330 --> 00:18:30,310 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +263 +00:18:30,310 --> 00:18:30,330 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +264 +00:18:30,330 --> 00:18:30,330 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +265 +00:18:30,330 --> 00:18:30,330 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +266 +00:18:30,330 --> 00:18:30,330 +مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش مش + +267 +00:18:30,530 --> 00:18:35,210 +فترضوا أنه أنا عملت فحوصات الـ coagulation واحد + +268 +00:18:35,210 --> 00:18:39,030 +بنزف وطلع عنده كل شي طلعت البلاستيكس طبيعية وطلع + +269 +00:18:39,030 --> 00:18:44,910 +الـ BT و الـ BTT normal بروح بعمل فحوصات عشان + +270 +00:18:44,910 --> 00:18:50,750 +تشوفلي factor 13 و factor 2 اللي هو الـ factor + +271 +00:18:50,750 --> 00:18:53,310 +عفواً one اللي هو الـ fibrinogen طبعا إذا كنتوا + +272 +00:18:53,310 --> 00:18:56,970 +فاكرين قلتلكم الـ BT و الـ BTT بشيكولي على الـ + +273 +00:18:56,970 --> 00:19:00,680 +coagulation cascade لعند الفيبرنجينالـ Fibrinogen + +274 +00:19:00,680 --> 00:19:04,460 +وFactor 13» لهم فحصات خاصة فيهم الـ Fibrinogen + +275 +00:19:04,460 --> 00:19:07,940 +باختبره من خلال الـ Thrombin Time Factor 13» من + +276 +00:19:07,940 --> 00:19:11,520 +خلال فحص اللي هو الـ Urea Solubility الآن لو كان + +277 +00:19:11,520 --> 00:19:16,240 +فيه Blading والـ BT وBTT Normal بروح بعمل الـ Urea + +278 +00:19:16,240 --> 00:19:20,340 +Solubility بشوف إذا كان Abnormal احتمال تبقى + +279 +00:19:20,340 --> 00:19:24,300 +Deficiency بFactor 13» طيب إذا كان Normal إذا كان + +280 +00:19:24,300 --> 00:19:28,670 +Normal فيه احتمالالاحتمال الأول أن يكون mild + +281 +00:19:28,670 --> 00:19:31,330 +factor deficiency يعني في factor deficiency لكن ما + +282 +00:19:31,330 --> 00:19:37,750 +ظهرت في الـBT وBTT ليش لأن الـBT وBTT 50% من ال + +283 +00:19:37,750 --> 00:19:41,800 +factor activity هتعطيني normal BT وBTTيعني لو كان + +284 +00:19:41,800 --> 00:19:44,640 +الـFactor نازل لمُص الـActivity بتاعته هيعطيني + +285 +00:19:44,640 --> 00:19:48,120 +Normal Pt وPtT طبعاً هذا بيقلل من الـSensitivity + +286 +00:19:48,120 --> 00:19:53,340 +تبعتهم عشان هيك احتمال يبقى فيه Deficiency لكن ما + +287 +00:19:53,340 --> 00:19:57,680 +بيّنت وما ظهر معايا Abnormality في الـPt وPtT ممكن + +288 +00:19:57,680 --> 00:20:01,840 +يبقى فيه خلل في الـFibrinolysis ممكن بسبب + +289 +00:20:01,840 --> 00:20:05,340 +elevation في الـFibrin degradationالـ Product ممكن + +290 +00:20:05,340 --> 00:20:08,980 +Monoclonal Gamma Pathy ممكن Platelet Disorder ممكن + +291 +00:20:08,980 --> 00:20:13,580 +Vascular Disorder يعني في مشاكل أخرى غير الـ + +292 +00:20:13,580 --> 00:20:19,140 +Factor Deficiency طيب نيجي نفترض أنه احنا عملنا + +293 +00:20:19,140 --> 00:20:22,540 +الـ BT و الـ BTT بغض النظر مين فيهم طلع Normal + +294 +00:20:22,540 --> 00:20:25,420 +ومين فيهم Abnormal طلع فيهم واحد Normal وواحد + +295 +00:20:25,420 --> 00:20:29,740 +Abnormal السيناريو المتبع أنه نشوف الـ Abnormality + +296 +00:20:29,740 --> 00:20:32,640 +هذه إيش سببها طبعا الـ Abnormality قد يكون سببها + +297 +00:20:32,640 --> 00:20:37,530 +Factor Deficiencyأو قد يكون سببها «factor + +298 +00:20:37,530 --> 00:20:41,730 +inhibitors» فأنا بدي أعمل الـ «mixing study» عشان + +299 +00:20:41,730 --> 00:20:45,550 +أعرف إذا كانت «factor deficiency» ولا «inhibitors» + +300 +00:20:45,550 --> 00:20:49,230 +طيب، كيف بعمل الـ «mixing study»؟ الـ «sample» + +301 +00:20:49,230 --> 00:20:53,770 +اللي بدي أستخدمها باخد نصها خليني أفترض إني بدي + +302 +00:20:53,770 --> 00:20:58,290 +أخد 100 ميكروليتر الـ 100 ميكروليتر هدول باخد 50 + +303 +00:20:58,290 --> 00:21:02,710 +منهم من الـ «sample» زائد 50 من «normal control» + +304 +00:21:02,710 --> 00:21:06,180 +مافيش فيه deficiencyإيش الهدف من عملية الـ Mix + +305 +00:21:06,180 --> 00:21:10,700 +هادى؟ هلاقيت لو كان فيه فعلًا Factor Deficiency + +306 +00:21:10,700 --> 00:21:13,740 +خمسين Micron اللي أخدتهم من الـ Normal Control + +307 +00:21:13,740 --> 00:21:17,320 +هتعوض الـ Deficiency هادى وتعطيني Normal Result + +308 +00:21:17,320 --> 00:21:21,900 +لكن لو كان فيه Inhibitor الخمسين Micron اللي + +309 +00:21:21,900 --> 00:21:24,700 +أضفتهم من الـ Normal Control برضه هيصير لهم + +310 +00:21:24,700 --> 00:21:29,280 +Inhibition فبالتالي مش هيصير تعويض للخلل وبالتالي + +311 +00:21:29,280 --> 00:21:34,470 +النتيجة هتظل Abnormal تمام؟ الـ Mixing Studyبعمل + +312 +00:21:34,470 --> 00:21:38,430 +mix للعينة نصها من العينة اللي أنا بشتغل عليها + +313 +00:21:38,430 --> 00:21:42,230 +اللي طلعت abnormal ونصها من عينة normal control + +314 +00:21:42,230 --> 00:21:45,930 +هلأ إذا صار correction وتصحيح للنتيجة معنى الكلام + +315 +00:21:45,930 --> 00:21:49,930 +إنه factor deficiency إذا ما صارش correction معنى + +316 +00:21:49,930 --> 00:21:53,670 +الكلام إنه في عندي inhibitors هي اللي قدت لل + +317 +00:21:53,670 --> 00:21:58,150 +prolongation، تمام؟ إذا خلّيني أخد نموذج في عندي + +318 +00:21:58,150 --> 00:22:03,380 +normal BT و abnormal BTTUpnormal BTT هذا بيدل على + +319 +00:22:03,380 --> 00:22:06,780 +إنه الخلل اللي جاي في الـ Intrinsic Pathway طب + +320 +00:22:06,780 --> 00:22:10,440 +إحنا ليش استثنين الـ Common Pathway؟ لأن الـ BTT + +321 +00:22:10,440 --> 00:22:14,720 +Normal لو كان في خلل في الـ Common Pathway هيبين + +322 +00:22:14,720 --> 00:22:17,600 +في الـ BTT صح؟ لأن الـ Common Pathway مشترك بين + +323 +00:22:17,600 --> 00:22:22,380 +التنين لذن وجود Normal BTT و Normal BTT بقول إن في + +324 +00:22:22,380 --> 00:22:26,640 +عندي خلل في الـ Intrinsic Pathway فبدي أعمل الـ + +325 +00:22:26,640 --> 00:22:31,120 +Mixing Studyفلقيت إذا ضل الفحص Abnormal إذا في + +326 +00:22:31,120 --> 00:22:33,900 +عندي Inhibitors للـ Factors تحت الـ Intrinsic + +327 +00:22:33,900 --> 00:22:38,320 +Pathway قد تكون Specific Inhibitors زي Factor 8 أو + +328 +00:22:38,320 --> 00:22:42,120 +9 أو 11 Inhibitors أو لان Specific Inhibitors زي + +329 +00:22:42,120 --> 00:22:44,060 +الـ Antilobus Anticoagulant اللي هي الـ + +330 +00:22:44,060 --> 00:22:48,920 +Antiphospholipid Antibody لكن الاحتمال التاني إنه + +331 +00:22:48,920 --> 00:22:53,630 +يصير Correction يعني لما أعمل Mixing Studyالـ + +332 +00:22:53,630 --> 00:22:57,030 +Correction للنتيجة معنى الكلام أنه فيه factor + +333 +00:22:57,030 --> 00:23:00,910 +deficiency فبدي أشوف أي factor فيه deficiency أو + +334 +00:23:00,910 --> 00:23:04,230 +ممكن أعمل assay لل factor بالـ one stage assay إذا + +335 +00:23:04,230 --> 00:23:07,730 +كنتوا فاكرين الـ one stage assay بستخدمه عشان أحدد + +336 +00:23:07,730 --> 00:23:12,030 +ال activity لكل factor على حدة ممكن تكون المشكلة + +337 +00:23:12,030 --> 00:23:15,910 +جاية من multiple factor deficiencies نفس الكلام + +338 +00:23:15,910 --> 00:23:19,850 +هنا يكرر أنه طلع عند الأبناء الـ BT الـ BT + +339 +00:23:19,850 --> 00:23:25,150 +abnormal والـ BTT normalهلقيت هنا بقول إنه المشكلة + +340 +00:23:25,150 --> 00:23:28,750 +في الـextrinsic pathway يعني الـextrinsic pathway + +341 +00:23:28,750 --> 00:23:32,090 +normal والcommon pathway normal بس المشكلة وين + +342 +00:23:32,090 --> 00:23:36,750 +تركزت في الـextrinsic pathway بدي أعمل الـmixing + +343 +00:23:36,750 --> 00:23:40,930 +studyاللأ إذا كانت ال mixing study abnormal ممكن + +344 +00:23:40,930 --> 00:23:43,390 +يكون specific factor inhibitor هيكون ال factor + +345 +00:23:43,390 --> 00:23:46,890 +الوحيد اللي بحكي عنه هنا factor 7 وهدي عادة rare + +346 +00:23:46,890 --> 00:23:50,630 +لما يكون فيه inhibitor ل factor 7 أو non-specific + +347 +00:23:50,630 --> 00:23:54,470 +inhibitor زي الـ antiphospholipids إذا صار + +348 +00:23:54,470 --> 00:23:58,900 +correction بعد ال mixing study بدي أعملdeficiency + +349 +00:23:58,900 --> 00:24:02,720 +يعني أعمل factor S عشان أشوف إذا كان فيه factor + +350 +00:24:02,720 --> 00:24:06,960 +deficiency زي أشوف isolated factor deficiency وعلى + +351 +00:24:06,960 --> 00:24:11,300 +فكرة factor 7 نادر لما بينقص لحاله عادة بتكون جاية + +352 +00:24:11,300 --> 00:24:14,300 +من multiple factor deficiency و ال multiple factor + +353 +00:24:14,300 --> 00:24:17,960 +deficiency هذه بتكون جاية من شغلة أثرت على vitamin + +354 +00:24:17,960 --> 00:24:22,500 +K لأن factor 7 من ضمن 2 و7 و9 و10 اللي هم بيصنعهم + +355 +00:24:22,500 --> 00:24:27,520 +vitamin Kإذا كان فيه vitamin K دفيشنسي هيأثر على + +356 +00:24:27,520 --> 00:24:31,380 +مجموعة factors من ضمنهم factors سبعة، تمام؟ زي + +357 +00:24:31,380 --> 00:24:34,540 +حالات liver disease و الـ vitamin K دفيشنسي و + +358 +00:24:34,540 --> 00:24:41,200 +حالات جرعات الوافرين و الـDIC طيب، + +359 +00:24:41,200 --> 00:24:45,860 +نيجي إن اتنين كانوا abnormal الـBT و الـBTT كانوا + +360 +00:24:45,860 --> 00:24:49,260 +abnormal إيش الاحتمالات؟ طبعاً برضه بدنا نعمل + +361 +00:24:49,260 --> 00:24:55,030 +mixing study بدنا نعمل mixing study نشوفالآن إذا + +362 +00:24:55,030 --> 00:24:58,670 +صار يعني ماصارش correction أو كانت النتيجة لازلة + +363 +00:24:58,670 --> 00:25:01,950 +abnormal معنى الكلام إنه فيه factor inhibitors + +364 +00:25:01,950 --> 00:25:06,370 +ممكن تكون specific factor inhibitors زي factor 5 و + +365 +00:25:06,370 --> 00:25:13,630 +10 و factor 2 و factor 2 ممكن تكون fibrinogen وهدي + +366 +00:25:13,630 --> 00:25:17,770 +أقل شيوعاً non-specific inhibitors هي الشائعة اللي + +367 +00:25:17,770 --> 00:25:21,610 +هي زي lobus anticoagulantالان لو صار correction + +368 +00:25:21,610 --> 00:25:24,450 +هيكون factor deficiency طب ال factor deficiency + +369 +00:25:24,450 --> 00:25:29,690 +هنا في أي منطقة هتكون غالباً هتكون في ال common + +370 +00:25:29,690 --> 00:25:33,130 +pathway لأن الاتنين مع بعض اتأثروا يعني إلا يكون + +371 +00:25:33,130 --> 00:25:36,630 +factors ال common pathway انضمنت أو بعض ال factors + +372 +00:25:36,630 --> 00:25:41,290 +من ال common pathway تأثرت في هذه ال deficiencyof + +373 +00:25:41,290 --> 00:25:44,230 +four-factor deficiency زي isolated deficiency in + +374 +00:25:44,230 --> 00:25:46,950 +common pathway زي factor خمسة، factor عشرة + +375 +00:25:46,950 --> 00:25:50,670 +البروثرومبين فيبرنجل أو multiple-factor deficiency + +376 +00:25:50,670 --> 00:25:54,530 +هذه عادة شائعة زي حالات المشاكل اللي قلنا عنها + +377 +00:25:54,530 --> 00:25:57,870 +تولي بتأثير على الـVitamin K dependent factors + +378 +00:26:05,020 --> 00:26:08,440 +في عندنا ملخص للـ Coagulation Factor Deficiencies + +379 +00:26:08,440 --> 00:26:11,440 +الـ Coagulation Factor Deficiencies في عندى six + +380 +00:26:11,440 --> 00:26:15,300 +linked الـ six linked طبعاً بيكون فيها هيموفيليا A + +381 +00:26:15,300 --> 00:26:18,460 +و هيموفيليا B هيموفيليا A و هيموفيليا B التانين + +382 +00:26:18,460 --> 00:26:21,720 +بيأثروا على الـ BTT لأنهم Intrinsic Factors الـ BT + +383 +00:26:21,720 --> 00:26:25,300 +بيكون Normal الـ Autosome Recessive Autosome + +384 +00:26:25,300 --> 00:26:28,520 +Recessive زي ال factors اللي ممكن يصير فيها + +385 +00:26:28,520 --> 00:26:35,470 +Deficiencies زي Factor 2 و 5 و 7 و 10 و 11هدول + +386 +00:26:35,470 --> 00:26:38,610 +ممكن يأثروا على التانين لأن في منهم بيجيوا بالـ + +387 +00:26:38,610 --> 00:26:43,110 +Common Pathway Factor 13 Deficiency is associated + +388 +00:26:43,110 --> 00:26:47,350 +with bleeding and impaired wound healing هيكون + +389 +00:26:47,350 --> 00:26:50,670 +الـBT وBTT Normal زي ما قلنا الـClot Solubility + +390 +00:26:50,670 --> 00:26:55,770 +Test أو الـUrea Solubility بيكون Abnormal Factor 2 + +391 +00:26:55,770 --> 00:26:58,710 +Brachial Acrine High Molecular Weight Deficiency + +392 +00:26:58,710 --> 00:27:01,970 +don't cause bleeding هذه الـFactors لو صانالفاكتور + +393 +00:27:01,970 --> 00:27:04,970 +عفوا مش اتنين فاكتور اتناش بريكاليكرين high + +394 +00:27:04,970 --> 00:27:08,050 +molecular weight kynogen هذه الفاكتور لو صار فيها + +395 +00:27:08,050 --> 00:27:15,510 +deficiency عادة ما بتسببش bleeding نيجي + +396 +00:27:15,510 --> 00:27:19,590 +للثرومبين تايم الثرومبين تايم هذا فحص قلنا بيشيك + +397 +00:27:19,590 --> 00:27:23,550 +على الفيبرينجين هل الفيبرينجين ال level بتاعه + +398 +00:27:23,550 --> 00:27:27,780 +normal ولا لأ كيف فكرتهفكرته بسيطة جدا أنا فيها + +399 +00:27:27,780 --> 00:27:31,060 +بعتمد على آخر خطوة من التفاعل اللي هو تحول الـ + +400 +00:27:31,060 --> 00:27:35,700 +Fibrinogen إلى Fibrin الـ Fibrinogen عشان يتحول لـ + +401 +00:27:35,700 --> 00:27:40,780 +Fibrin إيش بده؟ بده Thrombinفأنا بضيف كمية كبيرة + +402 +00:27:40,780 --> 00:27:44,880 +من الـ Thrombin و بسمح للـ Fibrinogen إنه يتحول + +403 +00:27:44,880 --> 00:27:48,940 +إلى Fibrin فلقيت أنا بغض النظر إيش في عندى + +404 +00:27:48,940 --> 00:27:53,080 +deficiency من ال factors في الـ cascade ما بهمني + +405 +00:27:53,080 --> 00:27:56,880 +ليش لأن أنا وفّرت آخر حاجة وفّرت الحاجة المسؤولة + +406 +00:27:56,880 --> 00:28:00,580 +عن تحويل الـ Fibrinogen إلى Fibrin فإذا صار تحويل + +407 +00:28:00,580 --> 00:28:03,620 +بالشكل المناسب معنى الكلام إن الـ Fibrinogen مش + +408 +00:28:03,620 --> 00:28:07,980 +فيه مشكلةلكن لو أنا وفّرت كل الظروف للـ fibrinogen + +409 +00:28:07,980 --> 00:28:11,820 +حطيت الاثرنبين بكمية كافية وما اتحولش لـ fibrin + +410 +00:28:11,820 --> 00:28:14,880 +معنى الكلام أن الـ fibrinogen نفسه هو اللي فيه + +411 +00:28:14,880 --> 00:28:19,720 +مشكلة bypass factor 2 و factor 12 يعني أنا بغض + +412 +00:28:19,720 --> 00:28:25,700 +النظر يعني بغض النظر إيش في عندي factors ما بين + +413 +00:28:25,700 --> 00:28:28,860 +factor 12 و factor 2 هل هي فيها deficiency أو + +414 +00:28:28,860 --> 00:28:32,580 +مافيهاش deficiency أنا تجاوزتهم وحطيت كمية كبيرة + +415 +00:28:32,580 --> 00:28:37,090 +منالـ Fibrin عفوا من الـ Thrombin «Add thrombin + +416 +00:28:37,090 --> 00:28:40,870 +with patient sample» «measure time to clot» بضيف + +417 +00:28:40,870 --> 00:28:45,850 +الـ Thrombin و بشوف العينة هل صار لها clot ولا لأ + +418 +00:28:45,850 --> 00:28:48,130 +إذا كان الـ time normal إذا الـ fibrin وجه الـ + +419 +00:28:48,130 --> 00:28:50,170 +normal إذا ماكنش الـ time normal إذا فيه + +420 +00:28:50,170 --> 00:28:54,270 +deficiency في الـ fibrin في بعض المتغيرات في الفحص + +421 +00:28:54,270 --> 00:28:57,830 +ترجع لطبيعة الفيس للـ Thrombin و أنا من وين جايبها + +422 +00:29:01,180 --> 00:29:03,580 +ما هي الأسباب اللي بتأدي للـ prolongation للـ + +423 +00:29:03,580 --> 00:29:06,760 +thrombin time؟ إذا كان ال patient بياخد هيبرين + +424 +00:29:06,760 --> 00:29:10,720 +ثيرابي لأنه الهيبرين بيشتغل كانتثرمبين فأنا لما + +425 +00:29:10,720 --> 00:29:14,600 +بضيف للثرمبين وفيه هيبرين هيعمله أكيد prolongation + +426 +00:29:14,600 --> 00:29:18,560 +نقص الـ fibrinogen أو فيه فيبرينوجين بس مش شغال + +427 +00:29:18,560 --> 00:29:21,820 +dysfibrinogenemia elevated fibrin degradation + +428 +00:29:21,820 --> 00:29:27,880 +products or paraproteins thrombin inhibitorsزي + +429 +00:29:27,880 --> 00:29:31,480 +الهيرودين و الـ thrombin antibodies كلها هذه + +430 +00:29:31,480 --> 00:29:37,720 +الأشياء ممكن تعمل elongation نيجي + +431 +00:29:37,720 --> 00:29:42,420 +لموضوع الـ thrombocytopenia و أجى مريض بدي أشوف + +432 +00:29:42,420 --> 00:29:45,920 +إذا كان يعني عنده thrombocytopenia عنده نفس في الـ + +433 +00:29:45,920 --> 00:29:50,780 +platelets بدي أخد ال history هل حصل عنده bleeding + +434 +00:29:50,780 --> 00:29:54,480 +مثلا هل عنده أمراض أخرى زي cancer زي autoimmune + +435 +00:29:54,480 --> 00:29:59,140 +diseaseهل بياخد أدوية معينة، بيتعاطى كحول، بيعانى + +436 +00:29:59,140 --> 00:30:03,400 +أو عنده risk factor للـHIV؟ هل في عنده family + +437 +00:30:03,400 --> 00:30:06,040 +history للـThrombocytopenia؟ عشان أعرف إيش سببها + +438 +00:30:06,040 --> 00:30:11,640 +طيب، هل في مثلا شكل ال bleeding أو ال spot بتاعة + +439 +00:30:11,640 --> 00:30:16,180 +البيتاكيا اللي صايرة، هل يعني أتوقع من خلالها إنه + +440 +00:30:16,180 --> 00:30:20,670 +في فعل platelet deficiency؟طبعا بعد هيك يعني بدنا + +441 +00:30:20,670 --> 00:30:24,930 +ناخد ال history بتاع المريض ال CPC هيبين عندي عدد + +442 +00:30:24,930 --> 00:30:28,230 +البلاتلت بعمل peripheral blood smear عشان أشوف شكل + +443 +00:30:28,230 --> 00:30:30,830 +البلاتلت برضه ال morphology تبعها مهم جدا لإنه + +444 +00:30:30,830 --> 00:30:34,750 +ممكن يكون عددها طبيعي بس هي non-functional بعمل + +445 +00:30:34,750 --> 00:30:38,750 +bleeding time أو bleeding أو blatlet aggregation + +446 +00:30:38,750 --> 00:30:45,150 +study هنا عندي رسم بياني بيوضح عندي علاقة عدد + +447 +00:30:45,150 --> 00:30:48,690 +البلاتلت بالأعراض اللي ممكن تظهر على المريضيعني + +448 +00:30:48,690 --> 00:30:54,050 +بقولك أنه مثلا هنا الـ Platelet count و هنا حدة + +449 +00:30:54,050 --> 00:30:57,090 +الأعراب يعني مثلا Zero, no bleeding Number one, + +450 +00:30:57,230 --> 00:31:01,230 +minimal bleeding Spontaneous, self-limited تلاتة, + +451 +00:31:01,290 --> 00:31:04,470 +spontaneous, requiring local treatment أربعة, + +452 +00:31:04,570 --> 00:31:08,030 +spontaneous, uncontrolled or poorly controlled عسب + +453 +00:31:08,030 --> 00:31:10,810 +الـ deficiency في الـ Platelets فلقيت لو أجينا + +454 +00:31:10,810 --> 00:31:14,030 +مثلا في الـ Range هذا إحنا قولنا إنه الـ Platelet + +455 +00:31:14,030 --> 00:31:20,620 +من 150 لغاية 450 ألفالـ Bladlet لو كانت من لغاية + +456 +00:31:20,620 --> 00:31:27,400 +تقريبا نقول 60 عادة ما بيصيرش bleeding بنبدأ عند + +457 +00:31:27,400 --> 00:31:31,680 +الخمسين بيصير احتمالية minimal bleeding تمام؟ لو + +458 +00:31:31,680 --> 00:31:36,900 +نقصدت عندها تقريبا من العشرين والتلاتين ممكن يكون + +459 +00:31:36,900 --> 00:31:41,280 +spontaneous self-limited bleeding لو نزلت عن عشرين + +460 +00:31:41,280 --> 00:31:46,920 +ممكن تزيد ال severity وتحتاج لـ treatmentلو نقصت + +461 +00:31:46,920 --> 00:31:51,080 +عن عشرة هنلاحظ أنه هيصير عندنا «severe bleeding, + +462 +00:31:51,280 --> 00:31:54,180 +uncontrolled or poorly controlled» فبتتالي عدد + +463 +00:31:54,180 --> 00:31:58,440 +الصفائح يعني مش مجرد ما تنزل الصفائح عن 150 هيبدأ + +464 +00:31:58,440 --> 00:32:01,340 +يصير bleeding وإحنا نلاحظ يعني إحنا بنلاحظه لما + +465 +00:32:01,340 --> 00:32:04,140 +يكون فعلا نزلت تقريبا عن 50 أو عند 40 + +466 +00:32:10,140 --> 00:32:14,160 +طيب هنا بقولك انه bleeding time and bleeding احنا + +467 +00:32:14,160 --> 00:32:17,120 +فيه فحص ل bleeding time هو فحص مش دقيق بالمرة + +468 +00:32:17,120 --> 00:32:24,920 +بنعمل من خلاله نشوف وضع ال platelets طبعا خمسة إلى + +469 +00:32:24,920 --> 00:32:27,820 +عشرة في المية من المرضى بنعمللهم بيعطوني prolonged + +470 +00:32:27,820 --> 00:32:31,380 +bleeding time وعادة بيكون ال prolongation نتيجة + +471 +00:32:31,380 --> 00:32:33,780 +بعض ال drugs اللي ممكن يكون مخدها المريض زي + +472 +00:32:33,780 --> 00:32:39,110 +الأسبرين أو غيرهطبعاً يعني لو أنا لقيت ال bleeding + +473 +00:32:39,110 --> 00:32:43,350 +time عالي مش شرط أنه هذا الشخص لو دخل عملية ممكن + +474 +00:32:43,350 --> 00:32:46,370 +ينزف لأنه انتوا عارفين ال bleeding time لو كان + +475 +00:32:46,370 --> 00:32:49,530 +عالي بيكون خلل في البلاتلت وخلل في البلاتلت بيصير + +476 +00:32:49,530 --> 00:32:53,930 +نزف بسيط عند بداية العملية وبنتي فبالتالي مش فحص + +477 +00:32:53,930 --> 00:32:57,010 +دقيق بالمرة اللي أفضل منه البلاتلت aggregate + +478 +00:33:00,060 --> 00:33:03,600 +conclusion a special calculation is a specialized + +479 +00:33:03,600 --> 00:33:07,440 +complex and dynamic field هو يعني موضوع مش سهل + +480 +00:33:07,440 --> 00:33:13,800 +ومتشعب ومتجدد وبده بحث باستمرار ويعطيكوا الف عافية + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I.srt new file mode 100644 index 0000000000000000000000000000000000000000..0433405312bdcd29b3641fee5807b24df197e646 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I.srt @@ -0,0 +1,1259 @@ +1 +00:00:00,660 --> 00:00:05,040 +بسم الله الرحمن الرحيم إن شاء الله رب العالمين في + +2 +00:00:05,040 --> 00:00:09,560 +هذا الفيديو راح نراجع مع بعض موضوع الـ Complete + +3 +00:00:09,560 --> 00:00:14,280 +Blood Count طبعا مش هناخد احنا فحص فحص و نقرأهم و + +4 +00:00:14,280 --> 00:00:17,160 +نعرف كيف .. إيش الـ Normal و إيش الـ Abnormal و + +5 +00:00:17,160 --> 00:00:20,560 +كيف بنشغله، لا يعني أنا اليوم بدي أجيبلكم نتائج + +6 +00:00:20,560 --> 00:00:24,920 +CBC و أركز كتير على جزئية الـ Histogram و الـ + +7 +00:00:24,920 --> 00:00:27,800 +Abnormalities اللي في الـ Histogram هذي إيش ده .. + +8 +00:00:27,800 --> 00:00:31,070 +إيش ده لإلها، إيش مدلولاتها في الـ Diagnosis يعني + +9 +00:00:31,070 --> 00:00:35,390 +كل حاجة قبل ما راح ناخدها وناخد إمتى ممكن تصير لها + +10 +00:00:35,390 --> 00:00:39,550 +لأنه يا بناتي الـCBC جزء لا يتجزأ من الـdiagnosis + +11 +00:00:39,550 --> 00:00:43,350 +للأنيميا من الأشياء المهمة جدا عشان أعرف أعمل + +12 +00:00:43,350 --> 00:00:48,730 +diagnosis جيد للأنيميا أني أعرف أقرأ إيه نيجي + +13 +00:00:48,730 --> 00:00:52,430 +لجزئية الـhistogram ونحاول نفهم أو نراجع مع بعض + +14 +00:00:52,430 --> 00:00:55,900 +إيش هو الـhistogram طبعا بالإضافة للـ Parameters + +15 +00:00:55,900 --> 00:00:59,000 +اللي بتلاقيها مكتوبة في الـ CBC اللي هو عد الـ + +16 +00:00:59,000 --> 00:01:01,740 +White PCs و الـ RBCs و الـ Platelets و الـ Blood + +17 +00:01:01,740 --> 00:01:05,800 +Indices هتلاقي عندك الـ Histograms هتلاقي عندك + +18 +00:01:05,800 --> 00:01:09,840 +ثلاثة Histograms واحد خاص في الـ Platelets واحد خاص + +19 +00:01:09,840 --> 00:01:14,870 +بالـ RBCs واحد خاص بالـ White PCs الـ Figure هذا + +20 +00:01:14,870 --> 00:01:19,550 +اللي عندنا يعني حاول إنه يحط التلاتة Histograms مع + +21 +00:01:19,550 --> 00:01:25,530 +بعض عشان يورجيكي كمقارنة يعني عامل ما بين الأحجام + +22 +00:01:25,530 --> 00:01:28,690 +بتاعة الخلايا حسب ما بيعدها الجهاز طبعا إحنا + +23 +00:01:28,690 --> 00:01:33,030 +عارفين إنه الجهاز بيعد الخلايا على حسب أحجامها + +24 +00:01:33,030 --> 00:01:37,570 +يعني مثلا بيعرف هذه Platelet في حجم معين بيعده إنه + +25 +00:01:37,570 --> 00:01:41,270 +Platelet إذا كانت من 2 إلى 20 مثلا بيعدها Platelet + +26 +00:01:41,700 --> 00:01:46,520 +من 36 إلى 360 بيعدها الـ Erythrocyte فيم توليتر + +27 +00:01:46,520 --> 00:01:51,220 +اللي هو الـ Diameter بتاع الخلية و هكذا طبعاً + +28 +00:01:51,220 --> 00:01:55,180 +الرسمة دي إيش مدلولها أو على إيش بتدل هنا عندي + +29 +00:01:55,180 --> 00:02:01,630 +حجم الخلية فده حجم الخلية تمام هنا الـ Frequency + +30 +00:02:01,630 --> 00:02:05,690 +تاعها يعني مثلًا بالنسبة للـ Platelet هذا الـ + +31 +00:02:05,690 --> 00:02:08,510 +Curve تاع الـ Platelet على سبيل المثال طلع معايا + +32 +00:02:08,510 --> 00:02:11,470 +هكذا هذا يوضح الـ Frequency للـ Platelet يعني + +33 +00:02:11,470 --> 00:02:16,290 +مثلًا عد عندي خلايا أربعة فمتو لتر الخلية حجمها + +34 +00:02:16,290 --> 00:02:20,570 +أربعة فمتو لتر هنا أداش في عندي خلايا أربعة فمتو + +35 +00:02:20,570 --> 00:02:24,470 +لتر خمسة فمتو لتر و هكذا يعني هنا بيبينلي حجم + +36 +00:02:24,470 --> 00:02:28,410 +الخلية وهنا بيبينلي ال Frequency تاع الخلية هذه + +37 +00:02:29,340 --> 00:02:33,980 +طبعاً برضه إذا كنا فاكرين إن الـ Platelets و الـ + +38 +00:02:33,980 --> 00:02:38,000 +Erythrocyte بنعدوا على نفس الشمبر في نفس الشمبر، + +39 +00:02:38,000 --> 00:02:41,820 +يعني في نفس المكان بس بيميز بينهم الجهاز على حسب + +40 +00:02:41,820 --> 00:02:48,920 +حجم الخلايا بينما الـ WBCs بتدخل في مسار تاني + +41 +00:02:48,920 --> 00:02:52,480 +بتقرأ هي و الـ Hemoglobin بحيث بيصير License للـ + +42 +00:02:52,480 --> 00:02:56,940 +RBCs وبتظل عندي بس الـ White Pieces بتم عد الـ + +43 +00:02:56,940 --> 00:03:00,140 +White Pieces برضه بنفس الطريقة على حسب أحجامها + +44 +00:03:00,140 --> 00:03:06,220 +تصنف إلى lymphocyte وإلى mid وgranulocyte وبعد هيك + +45 +00:03:06,220 --> 00:03:11,160 +في نفس الشمبر بتم قراءة الهيموجلوبين باستخدام كتبة + +46 +00:03:11,160 --> 00:03:14,620 +الـ photometry يعني بتمرير ضوء معين وقياس ال + +47 +00:03:14,620 --> 00:03:19,310 +absorbance وبحسب للجهاز الهيموجلوبين إذاً هذه + +48 +00:03:19,310 --> 00:03:23,790 +الرسمة هو دامش فيها التلاتة Histograms مع بعض إحنا + +49 +00:03:23,790 --> 00:03:27,570 +في الـCBC بنشوف كل واحدة لحال البلاتلت لحال + +50 +00:03:27,570 --> 00:03:33,030 +والـRBCs لحال والـWhite PCs لحال المرحلة اللي بعد + +51 +00:03:33,030 --> 00:03:36,330 +هيك حنا خد واحد واحد ونشوف الـAbnormalities اللي + +52 +00:03:36,330 --> 00:03:39,610 +ممكن تسير في الـCurve وانا كيف لما أشوفها في + +53 +00:03:39,610 --> 00:03:43,210 +الـHistogram كيف أنا ممكن أستدل من خلالها على وجود + +54 +00:03:43,210 --> 00:03:49,380 +خلل معين أو حالة مرضية معينة هذا رسم يعني لا مش + +55 +00:03:49,380 --> 00:03:53,180 +بالشرط يكون رسم صحيح يعني الـ Platelets في + +56 +00:03:53,180 --> 00:03:56,180 +Instagram ما بيكون شكله هيك والـ Granulocyte برضه + +57 +00:03:56,180 --> 00:04:00,280 +هنا ما بتكون هيك يعني بس هو كرسم تخطيطي عشان هذا + +58 +00:04:00,280 --> 00:04:04,060 +الهدف منه أنه يبينلك المقارنة بين أحجام الخلايا + +59 +00:04:04,060 --> 00:04:08,060 +يعني أصغر حاجة لـPlatelets هلأ الـRBCs بعد هيك + +60 +00:04:08,060 --> 00:04:11,180 +الـLymphocyte بتيجي تقريبا قريبة من الـRBCs + +61 +00:04:11,180 --> 00:04:16,390 +والـMonocytes والـ mid-cells بعد هيك للـ + +62 +00:04:16,390 --> 00:04:20,970 +granulocyte طيب + +63 +00:04:20,970 --> 00:04:24,970 +نيجي هنا للهيستوجرام بتاع الـ platelets وتاع + +64 +00:04:24,970 --> 00:04:30,710 +الاريثرocyte عند البلاتلت بتنعد تقريبا من 2 إلى 20 + +65 +00:04:30,710 --> 00:04:34,840 +أو إلى 25 بيعدها الجهاز على إنها platelets ايه بعد + +66 +00:04:34,840 --> 00:04:37,900 +هيك بيصير انخفاض في ال curve في ال histogram وبيبلش + +67 +00:04:37,900 --> 00:04:41,180 +يطلع اللي هو بتاع ال RBCs احنا ماهنشوفهم هيك في ال + +68 +00:04:41,180 --> 00:04:45,080 +histogram في ال CBC احنا هنشوف كل واحد لحال لكن هم + +69 +00:04:45,080 --> 00:04:48,000 +فعليا يعني بتيجي ال platelets و بتخلص بعد هيك + +70 +00:04:48,000 --> 00:04:51,700 +التدائل erythrocyte هلاقيت لو أجينا للـ Histogram + +71 +00:04:51,700 --> 00:04:56,440 +مثلا لـ Platelet الـ Platelet متوسط حجمها من 8 إلى + +72 +00:04:56,440 --> 00:05:00,880 +12 فهتلاقي أكتر ارتفاع من 8 إلى 12 لماذا؟ لأن معظم + +73 +00:05:00,880 --> 00:05:04,320 +الخلايا هتقع في الـ Normal Range صح؟ لشان هيك هو + +74 +00:05:04,320 --> 00:05:07,520 +أخد هذا المنظر أكتر accumulation أو أكتر + +75 +00:05:07,520 --> 00:05:11,630 +percentage للخلايا هتلاقيها في هذه المنطقة نفس + +76 +00:05:11,630 --> 00:05:15,410 +الأشي بالنسبة للـ RBCs هتلاقي الارتفاع في منطقة + +77 +00:05:15,410 --> 00:05:19,190 +الـ MCV الـ Normal من 80 إلى 100، هذا + +78 +00:05:19,190 --> 00:05:24,240 +إذا كانت العينة طبعا Normal هتلاقي فيه تقريبًا + +79 +00:05:24,240 --> 00:05:28,680 +تطابق مع الـ MCV مع الـ Peak يعني وين الـ Peak + +80 +00:05:28,680 --> 00:05:33,200 +بتاعة الـ Histogram هتلاقيها تقريبًا نفسها هي الـ + +81 +00:05:33,200 --> 00:05:36,820 +MCV ليش؟ لأن الـ MCV هي الـ Mean Volume بتاع + +82 +00:05:36,820 --> 00:05:41,080 +الخلايا المتوسط، متوسط حجم الخلايا وأكيد القيمة + +83 +00:05:41,080 --> 00:05:45,140 +المتوسطة ده الـ Average عادةً هو يمثل أكثر القيم + +84 +00:05:45,140 --> 00:05:48,380 +اضطرارًا في الـ Curve، تمام؟ + +85 +00:06:00,260 --> 00:06:04,700 +هنا الـ white pieces Histogram هلأ في الـ white + +86 +00:06:04,700 --> 00:06:09,380 +pieces Histogram بيوضّح عندك ال .. ال .. ال peaks + +87 +00:06:09,380 --> 00:06:13,360 +التلاتة في عندي الـ lymphocyte هذه أول peak لأن + +88 +00:06:13,360 --> 00:06:16,600 +أصغر حجم خلايا هي الـ lymphocyte بعد هيك بتيجي + +89 +00:06:16,600 --> 00:06:20,480 +عندي الـ monocyte والبازوفيل والإزينوفيل بعد هيك + +90 +00:06:20,480 --> 00:06:26,480 +لـ neutrophil الآن السؤال اللي بترح نفسه أنه يعني + +91 +00:06:26,480 --> 00:06:29,360 +إحنا بنعرف إنه الـ Monocyte أكبر من الـ Neutrophil + +92 +00:06:29,360 --> 00:06:33,740 +مثلا طيب ليش الـ Neutrophil اعتبرها الجهاز أكبر؟ + +93 +00:06:33,740 --> 00:06:36,520 +إذا كنتوا فاكرين الـ Principle تاعة قراءة القراءة + +94 +00:06:36,520 --> 00:06:41,900 +تاعة الـ White PCs قلنا إنه الجهاز بياخد الخلايا + +95 +00:06:41,900 --> 00:06:46,060 +بيعمل لها بيعمل للـ RBC slicing في الشمبر تاع الـ + +96 +00:06:46,060 --> 00:06:50,000 +White PCs ونفس المحلول الـ Lysing Reagent اللي أنا + +97 +00:06:50,000 --> 00:06:54,200 +بحطه بعمل Shrinking للـ White BCs يعني بعمل + +98 +00:06:54,200 --> 00:06:59,500 +Collapse للخلية حوالين النواء فبالتالي بيصير حجم + +99 +00:06:59,500 --> 00:07:05,560 +الـ Cytoplasm لا قيمة له وبتم العد الحقيقي حسب حجم + +100 +00:07:05,560 --> 00:07:10,320 +النواء عشان هيك لـ Neutrophil إن عدت علي إنها أكبر + +101 +00:07:10,320 --> 00:07:15,090 +واحدة وهدول كلهم بيعدهم ضمن الـ mid-region اللي هي + +102 +00:07:15,090 --> 00:07:21,330 +الـ monocyte والبازوفيل والإزينوفيل خلّيني أنا أخد + +103 +00:07:21,330 --> 00:07:25,170 +بعض الأمثلة اللي يعني نحط فيها بعض صور الـ + +104 +00:07:25,170 --> 00:07:31,190 +histogram ونحاول نشوف إيش دلالتها عندي هنا two + +105 +00:07:31,190 --> 00:07:38,970 +CBCs والتانية اللي لهم علاقة بالأنميا لكن يعني في + +106 +00:07:38,970 --> 00:07:44,360 +فرق في ال diagnosis بس اشتراك في الـ category بتاعة + +107 +00:07:44,360 --> 00:07:48,600 +الانيمي خلينا نفهم إيش الكلام اللي بقوله الآن لو + +108 +00:07:48,600 --> 00:07:56,020 +إجينا نبطلع على ال histogram أول حاجة راح نلاحظها + +109 +00:07:56,020 --> 00:08:03,750 +إن ال RBCs Histogram صار له شوية shift to left يعني + +110 +00:08:03,750 --> 00:08:08,890 +الـ Peak مفروض تكون ما بين 80 إلى 100 لكن هنا الـ + +111 +00:08:08,890 --> 00:08:14,190 +Peak لا تقريبا عند بين الـ 60 والـ 70 طيب على إيش + +112 +00:08:14,190 --> 00:08:19,870 +بدل هذا؟ على إنه حجم الخلايا صغير والتاني نفس + +113 +00:08:19,870 --> 00:08:24,590 +الاشي الـ Histogram إنه صاير Shift to Left لو + +114 +00:08:24,590 --> 00:08:29,110 +أجينا نتطلع على الـ MCV فعلا هنلاقي إن الـ MCV + +115 +00:08:29,110 --> 00:08:35,260 +منخفضة في التنين هنا 65 وفي التاني 68 وهذا اللي عمل + +116 +00:08:35,260 --> 00:08:39,920 +إزاحة للـ Histogram إلى جهة اليسار إزاحة لليسار + +117 +00:08:39,920 --> 00:08:45,040 +يعني الخلايا الـ Microcytic طيب، هذا برضه راح يأثر + +118 +00:08:45,040 --> 00:08:49,080 +عندي على الـ Platelet Histogram لأنه هيكون في عندي + +119 +00:08:49,080 --> 00:08:53,830 +RBCs صغيرة هتظهر في الـ Area ما بين الـ Platelet + +120 +00:08:53,830 --> 00:08:57,450 +Histogram و الـ Erythrocyte Histogram وهذا اللي + +121 +00:08:57,450 --> 00:09:01,170 +ظاهر فعليًا في الـ Platelet Histogram زي ما انتوا + +122 +00:09:01,170 --> 00:09:04,510 +شايفين لو أجينا نطلع على الـ Platelet Histogram + +123 +00:09:04,510 --> 00:09:09,370 +المفروض ينزل لـ Platelet Histogram لكن في عند هنا + +124 +00:09:09,370 --> 00:09:13,570 +شوية ارتفاع ما بين الـ Platelet Histogram و الـ + +125 +00:09:13,570 --> 00:09:17,950 +Erythrocyte Histogram طبعاً إذا دل على شيء هذا يدل + +126 +00:09:17,950 --> 00:09:23,630 +على إنه في عندي أشياء حجمها متوسط ما بين الـ + +127 +00:09:23,630 --> 00:09:28,650 +Platelets والـ Erythrocytes عيننا هنا يتضح إنه هي + +128 +00:09:28,650 --> 00:09:33,070 +عبارة عن Microcytic Erythrocytes لأن الـ MCV قليل + +129 +00:09:33,070 --> 00:09:37,930 +طيب هنا لو أجينا نشوف الـ diagnosis هنلاقي الـ + +130 +00:09:37,930 --> 00:09:42,430 +diagnosis هنا Iron Deficiency Anemia بينما هنا الـ + +131 +00:09:42,430 --> 00:09:47,870 +diagnosis Suspected ثلاثيمية طيب خلينا نشوف لو + +132 +00:09:47,870 --> 00:09:53,210 +أجينا للـ RBCs للـ CBC عفواً في الـ Iron Deficiency + +133 +00:09:53,210 --> 00:09:57,350 +أنيميا هنلاقي الـ RBCs منخفضة والثلاثيمية هنلاقيها + +134 +00:09:57,350 --> 00:10:03,210 +مرتفعة شغلة ثانية لو أجينا يعني الـ MCV أحياناً + +135 +00:10:03,210 --> 00:10:06,030 +كتير في الثلاثيمية بيكون تحت السبعين بينما + +136 +00:10:06,030 --> 00:10:09,630 +بالـ Iron Deficiency بيكون فوق السبعين وإن كان هنا + +137 +00:10:09,630 --> 00:10:13,350 +الاثنين في تشابه بينهم الاثنين تحت السبعين فبالتالي + +138 +00:10:13,350 --> 00:10:21,450 +هذا ما فصل عندي بين الاثنين اللي هو الـ MCV نيجي + +139 +00:10:21,450 --> 00:10:27,290 +لحاجة مهمة كتير اللي هي الـ RDW الـ RDW عادة تدل + +140 +00:10:27,290 --> 00:10:31,460 +على درجة الـ variation في أحجام الخلايا وهذه الـ + +141 +00:10:31,460 --> 00:10:35,480 +RDW يعني من الأشياء المهمة جدًا اللي بنفرق من + +142 +00:10:35,480 --> 00:10:38,900 +خلالها ما بين الثلاثيميا والـ Iron Deficiency + +143 +00:10:38,900 --> 00:10:42,240 +Anemia هنا في الـ Iron Deficiency Anemia هنلاقيه + +144 +00:10:42,240 --> 00:10:44,940 +مرتفع لأنه في الـ Iron Deficiency الخلايا بيكون + +145 +00:10:44,940 --> 00:10:48,480 +فيه variation في أحجامها بينما في الثلاثيميا + +146 +00:10:48,480 --> 00:10:54,020 +هنلاقيه تقريبًا Normal اللي هو 14.7% مما يدل على + +147 +00:10:54,020 --> 00:10:58,520 +أنه فيه تقارب في أحجام الخلايا الصغيرة لكن فيه تقارب في + +148 +00:10:58,520 --> 00:11:02,780 +أحجام الخلايا إذا الحالتين لنفس الكاتيجوريا + +149 +00:11:02,780 --> 00:11:06,940 +Microcytic Hypochromic Anemia Microcytosis and + +150 +00:11:06,940 --> 00:11:12,340 +Hypochromia وهذه الاثنين كان في .. إيش الـ + +151 +00:11:12,340 --> 00:11:15,700 +diagnosis؟ هو بقولك هنا دي Suspected Thalassemia + +152 +00:11:15,700 --> 00:11:19,500 +طبعاً بنعمل confirmation بـ Hemoglobin A2 and + +153 +00:11:19,500 --> 00:11:21,220 +Hemoglobin Electrophoresis + +154 +00:11:23,120 --> 00:11:27,760 +بنجي لصورة ثانية بتجمع ما بين الـ Histogram بتاع + +155 +00:11:27,760 --> 00:11:32,320 +الـ RBCs وبتاع الـ YPCs خلينا أول حاجة ناخد هذا + +156 +00:11:32,320 --> 00:11:36,360 +الـ Histogram هنا عند الـ Histogram لو أجينا نطلع + +157 +00:11:36,360 --> 00:11:41,040 +هنلاقيه Bimodal بقولك هذه الحالة عبارة عن Iron + +158 +00:11:41,040 --> 00:11:45,550 +deficiency anemia under treatment يعني بداية كانت + +159 +00:11:45,550 --> 00:11:50,030 +الخلايا Microcytic لكن لما بلش المريض بلشت تظهر + +160 +00:11:50,030 --> 00:11:54,190 +عندي كاتيجوري ثانية من الخلايا اللي هي Normocytic + +161 +00:11:54,190 --> 00:12:01,770 +فصار عندي الـ Histogram Bimodal بعد أربع أسابيع من + +162 +00:12:01,770 --> 00:12:06,810 +العلاج لو نزلنا لتحت بالصورة هنلاحظ إنه بلشت + +163 +00:12:06,810 --> 00:12:10,570 +الخلايا اللي حجمها طبيعي ترتفع وتصير أكثر من + +164 +00:12:10,570 --> 00:12:14,950 +الخلايا الـ Microcytic هذا بيدل على إنه في استجابة + +165 +00:12:14,950 --> 00:12:18,810 +في العلاج طبعاً لو أجينا إحنا نتطلع على الـ + +166 +00:12:18,810 --> 00:12:22,910 +Histogram هنلاقي الـ Histogram هنا صار عندي واسع + +167 +00:12:22,910 --> 00:12:29,070 +أو عريض كتير هذا أكيد الـ RDW لإله هتكون عالية الـ + +168 +00:12:29,070 --> 00:12:34,150 +RDW بالمفهوم البسيط هي الـ Variation بين أحجام + +169 +00:12:34,150 --> 00:12:39,850 +الخلايا وممكن لو طلعنا على الـ Histogram ناخد فكرة + +170 +00:12:39,850 --> 00:12:45,790 +عن وضع الـ RDW لأنها ببساطة Red Distribution Curve + +171 +00:12:45,790 --> 00:12:49,420 +Width يعني هذا الـ Curve بتاع الـ Erythrocyte قداش + +172 +00:12:49,420 --> 00:12:52,840 +الـ Width بتاعه، قداش العرض أو قداش الاتساع بتاع + +173 +00:12:52,840 --> 00:12:56,520 +الـ Curve فكل ما كان الـ Curve أعرض، دال على إنه + +174 +00:12:56,520 --> 00:13:02,580 +فيه تباين أكثر للخلايا وكل ما دال على إنه الـ RDW + +175 +00:13:02,580 --> 00:13:06,380 +مرتفع أكثر، إذن هذه حالة Iron Deficiency Anemia + +176 +00:13:06,380 --> 00:13:10,890 +Under Treatment طيب، نيجي للحالة الثانية اللي على + +177 +00:13:10,890 --> 00:13:13,730 +الجهة الثانية من الـ slide اللي هي الـ Macrocytic + +178 +00:13:13,730 --> 00:13:19,210 +Anemia وهي بقولك حالة CML طبعاً خلينا ناخدهم واحدة + +179 +00:13:19,210 --> 00:13:22,790 +واحدة الـ RBCs Histogram لحال والـ White BCs + +180 +00:13:22,790 --> 00:13:25,870 +Histogram لحال أول حاجة هو حاكي عن الـ White BCs + +181 +00:13:25,870 --> 00:13:29,370 +Histogram طبعاً إحنا بنعرف إن الـ White BCs + +182 +00:13:29,370 --> 00:13:32,710 +Histogram في ثلاثة Flags الأولى اللي هي الـ + +183 +00:13:32,710 --> 00:13:37,420 +Lymphocyte الثانية الـ Med الثالثة لـ Granulocyte + +184 +00:13:37,420 --> 00:13:41,240 +أو اللي هي لـ Neutrophil هنا هنلاحظ ارتفاع في + +185 +00:13:41,240 --> 00:13:44,960 +منطقة الـ Med فهذا بيدل على وجود Immature + +186 +00:13:44,960 --> 00:13:48,880 +Granulocyte بكل أنواعها، ممكن تكون Myelocyte، + +187 +00:13:48,880 --> 00:13:52,480 +Metamyelocyte وانتوا عارفين الـ CML بيبقى فيها + +188 +00:13:52,480 --> 00:13:57,420 +Abnormal Cells اللي هي Immature Stages من الـ + +189 +00:13:57,420 --> 00:14:01,440 +Granulocyte فهي ظهرت في الـ Histogram في هذه + +190 +00:14:01,440 --> 00:14:08,260 +المنطقة الشغل الثاني اللي بدنا نحكيها اللي هي بخصوص + +191 +00:14:08,260 --> 00:14:14,700 +الـ RBCs Histogram لو لاحظنا هنلاقي إن الـ + +192 +00:14:14,700 --> 00:14:18,280 +Erythrocyte Histogram صار له Shift لفت يعقف عن Shift + +193 +00:14:18,280 --> 00:14:23,080 +Right يعني الـ Curve كله اتحرك إلى جهة اليمين هذا + +194 +00:14:23,080 --> 00:14:27,200 +إذا دل على شيء بيدل على إن الخلايا حجمها كبير طيب + +195 +00:14:27,200 --> 00:14:31,320 +نشوف الـ MCV هل الخلايا فعلاً حجمها كبير فعلاً + +196 +00:14:31,320 --> 00:14:39,680 +الخلايا كبيرة 110 فمتو لتر فبالتالي استنتاجنا كان + +197 +00:14:39,680 --> 00:14:46,650 +صحيح طيب نيجي هنا لحالات يعني متفرقة هنا بقولك حالة + +198 +00:14:46,650 --> 00:14:51,490 +Anisocytosis يعني في عندي Variation بالـ RBCs Size + +199 +00:14:51,490 --> 00:14:55,950 +أكثر حاجة بلاحظها، بنات إحنا ممكن هنا ألاحظ أن الـ + +200 +00:14:55,950 --> 00:15:00,010 +MCV تقريبًا تقريبًا يعني Within الـ Normal Range على + +201 +00:15:00,010 --> 00:15:03,270 +الـ Upper Limit الـ Normal إحنا قولنا من 80 لـ 97 + +202 +00:15:03,270 --> 00:15:07,650 +أعلى شوية من الـ Normal يعني الخلايا حجمها أكبر + +203 +00:15:07,650 --> 00:15:12,700 +شوية لكن الأكثر، الحاجة الملحوظة أكثر إنه فيه تباين + +204 +00:15:12,700 --> 00:15:17,240 +كتير كبير في حجم الخلايا دليل هيك إنه شايفين الـ + +205 +00:15:17,240 --> 00:15:22,020 +Histogram أوسع من هذه المنطقة طبعاً اتساع الـ + +206 +00:15:22,020 --> 00:15:26,060 +Histogram بيدل على إنه الـ RDW عالي وإنه فيه تباين + +207 +00:15:26,060 --> 00:15:33,080 +كبير بين أحجام الخلايا طب نشوف الـ RDW 22.7% صحيح + +208 +00:15:33,080 --> 00:15:37,080 +الكلام، إذن في عندي Variation في أحجام الخلايا + +209 +00:15:37,080 --> 00:15:42,400 +كبيرة وهذا نفس الفكرة عندنا لو لاحظنا هنلاقي الـ + +210 +00:15:42,400 --> 00:15:49,760 +MCV مرتفعة والـ RDW برضه 26 وهذا طبعاً استدلان + +211 +00:15:49,760 --> 00:15:57,520 +عليه كمان من خلال اتساع الـ Histogram نيجي + +212 +00:15:57,520 --> 00:16:00,680 +لهنا حاجة خاصة بالـ Curve بتاع الـ Platelet أو + +213 +00:16:00,680 --> 00:16:04,200 +بالـ Histogram بتاع الـ Platelet هنا لو لاحظنا + +214 +00:16:04,200 --> 00:16:11,830 +هنلاقي الـ Histogram عريض شوية بالإضافة بالإضافة + +215 +00:16:11,830 --> 00:16:15,710 +مثلاً في عندي في الـ Castle في عندي في هذه المنطقة + +216 +00:16:15,710 --> 00:16:19,670 +ارتفاع في Flag في هذه المنطقة في عندي هنا حاجة + +217 +00:16:19,670 --> 00:16:24,010 +بيسموها Percent of Large Cells أو Percent of + +218 +00:16:24,010 --> 00:16:26,510 +Large Platelets هذا بيبين عندي نسبة قداش في عندي + +219 +00:16:26,510 --> 00:16:30,890 +Giant Platelets هنا عندي 44% يعني نسبة عالية من + +220 +00:16:30,890 --> 00:16:34,620 +الـ Giant Platelets Platelet Distribution Width + +221 +00:16:34,620 --> 00:16:37,860 +برضه الـ Distribution Width للـ Platelets زي وزي + +222 +00:16:37,860 --> 00:16:41,200 +الـ Distribution Width للـ RBCs بيبين عندي قداش + +223 +00:16:41,200 --> 00:16:44,600 +فيه تباين بأحجام الـ Platelets عندي برضه هنا هي + +224 +00:16:44,600 --> 00:16:48,550 +أعطاني Flag إنه مرتفع عالي زي ما أنتم تفكرون واللي + +225 +00:16:48,550 --> 00:16:52,310 +دلّل عندي هنا على وجود Giant Platelets وجود الـ + +226 +00:16:52,310 --> 00:16:55,770 +Curve هنا فيه يعني مش نازل زي ما إحنا متعودين هو + +227 +00:16:55,770 --> 00:16:59,790 +من 6 إلى 8 وبينزل لكن عندي هنا في هذه الحالة Case + +228 +00:16:59,790 --> 00:17:02,330 +2 زي ما أنتم ملاحظين كتير هذه واضحة إنه Large + +229 +00:17:02,330 --> 00:17:06,510 +Platelets وبأحجام متباينة والـ Curve عند نهايته + +230 +00:17:06,510 --> 00:17:10,950 +هنا ما نزل يعني ظل الـ Curve مرتفع دليل على وجود + +231 +00:17:10,950 --> 00:17:15,790 +Platelets وشبك مع الـ RBCs Histogram يعني ممكن حتى + +232 +00:17:15,790 --> 00:17:17,450 +هنا يكون فيه Large Platelets + +233 +00:17:20,570 --> 00:17:25,310 +هنا نيجي للـ Platelet Aggregation كيف ممكن تظهر + +234 +00:17:25,310 --> 00:17:29,730 +الـ Platelet Aggregation ممكن تظهر معايا على شكل + +235 +00:17:29,730 --> 00:17:32,910 +إن الـ Curve برضه ما انتهى يعني لأنه الـ + +236 +00:17:32,910 --> 00:17:38,150 +Platelet Aggregate هتنعد على إنه كل مجموعة من الـ + +237 +00:17:38,150 --> 00:17:41,950 +Aggregate هتنعد على إنها Large Platelet فهيكون وضع + +238 +00:17:41,950 --> 00:17:44,910 +الـ Histogram شبيه بوضع الـ Giant أو Large + +239 +00:17:44,910 --> 00:17:49,760 +Platelet الـ Platelet Aggregates هتظهر مع الـ White + +240 +00:17:49,760 --> 00:17:53,080 +BCs كمان يعني هيظهر في عندي Flag قبل الـ + +241 +00:17:53,080 --> 00:17:56,120 +Lymphocyte في هذه المنطقة في الـ Histogram بتاع + +242 +00:17:56,120 --> 00:17:59,740 +الـ White BCs إذا ظهر معايا احتمال يكون وجود + +243 +00:17:59,740 --> 00:18:03,080 +Platelet Aggregate هاي واضح في Case 1 وفي Case 2 + +244 +00:18:03,080 --> 00:18:06,680 +إن الـ Curve ضلوا في البلاتلت مرتفع Curve + +245 +00:18:06,680 --> 00:18:09,500 +البلاتلت ضلوا مرتفع هنا زي ما أنتم شايفين + +246 +00:18:09,500 --> 00:18:13,710 +ما انتهى بيقول نفس الشيء ظهرت عندي Flag في Curve + +247 +00:18:13,710 --> 00:18:17,790 +الـ RBCs أو الـ Histogram تاع الـ … عفواً، عفواً، + +248 +00:18:17,790 --> 00:18:21,510 +ظهر هنا Flag في الـ Histogram تاع الـ White Blood Cells + +249 +00:18:25,290 --> 00:18:29,010 +وجود Cold Agglutinin Cold Agglutinin يعني + +250 +00:18:29,010 --> 00:18:32,790 +Irregular Agglutination للخلايا يعني هتلاقي في + +251 +00:18:32,790 --> 00:18:36,990 +عندنا Variation في الـ Size في خلايا خلية لحالة في + +252 +00:18:36,990 --> 00:18:40,750 +تنتين في تلاتة يعني كأنه أنا بحكي عن Anisocytosis + +253 +00:18:40,750 --> 00:18:44,850 +بالـ Picture هنا بالـ Picture هيكون عندي الـ RDW + +254 +00:18:44,850 --> 00:18:48,450 +عالية ليش؟ لأنه فيه تباين فيه خليتان وفيه تلاتة + +255 +00:18:48,450 --> 00:18:52,510 +اتجمعوا فيه أكثر من هيك فبالتالي كل مجموعة هتنعد + +256 +00:18:52,510 --> 00:18:57,790 +على أنها خلية ذات حجم خاص فهذا هيعطيني إشارة على + +257 +00:18:57,790 --> 00:19:02,530 +أنه فيه تباين بأحجام الخلايا ويبقى الـ RDW مرتفع + +258 +00:19:02,530 --> 00:19:06,790 +زي ما إحنا شايفين هنا هي لو لاحظنا هي الـ Curve + +259 +00:19:06,790 --> 00:19:11,150 +والـ Curve برضه لو لاحظنا برضه الـ MCV مرتفعة لأن + +260 +00:19:11,150 --> 00:19:14,810 +الخلايا بدل ما تكون عدد واحدة واحدة هنصير عدة + +261 +00:19:14,810 --> 00:19:18,430 +جمعات كبيرة مما يزيد من الـ MCV إذا الـ Curve + +262 +00:19:18,430 --> 00:19:22,410 +صار لها Shift to Right بعدين في عندنا Flag وجود دليل + +263 +00:19:22,410 --> 00:19:25,450 +على وجود يعني أنه ما خلص الـ Curve دليل على أنه في + +264 +00:19:25,450 --> 00:19:28,630 +خلايا كبيرة هنا الخلايا الكبيرة هنا فعليًا هي + +265 +00:19:28,630 --> 00:19:32,980 +عبارة عن Cold Agglutinates هنا بقولك تجربة حلوة إحنا + +266 +00:19:32,980 --> 00:19:36,380 +بعد ما عملنا نفس العينة عملنا لها Incubation + +267 +00:19:36,380 --> 00:19:40,560 +ثلاثين دقيقة في سبعة وثلاثين درجة عشان نفكك الـ + +268 +00:19:40,560 --> 00:19:43,300 +Agglutination وعملنا منها فيلم وعملنا منها CBC + +269 +00:19:43,300 --> 00:19:46,480 +طلعت معانا النتيجة اللي على الجهة هذه نشوف إيش طلع + +270 +00:19:46,480 --> 00:19:49,840 +معانا أول حاجة الـ Blood Film صار Normal كان + +271 +00:19:49,840 --> 00:19:53,800 +بالأول فيه Agglutinates لكن هنا صار عندي Normal + +272 +00:19:53,800 --> 00:19:58,100 +الشغلة الثانية المهمة لو إجينا للـ Histogram + +273 +00:19:58,100 --> 00:20:03,460 +هنلاقي الـ Histogram صار طبيعياً كمان الـ MCV انخفضت + +274 +00:20:03,460 --> 00:20:07,180 +كانت هنا 111 بالأول قبل ما أعمل Incubation كانت + +275 +00:20:07,180 --> 00:20:11,780 +111، هنا صارت 100، ليش؟ لأن الـ Large Aggregates + +276 +00:20:11,780 --> 00:20:16,760 +تفككت إلى حد ما وعطتني Normal Result أو Normal + +277 +00:20:16,760 --> 00:20:21,120 +Reading، بعدين الـ Flag اللي ظهرت في نهاية عدد تل + +278 +00:20:21,120 --> 00:20:24,580 +تاع الـ Histogram ما ظهرت بعد الـ Incubation، دليل + +279 +00:20:24,580 --> 00:20:27,100 +على أن الأجلوتينيات تفككت + +280 +00:20:31,160 --> 00:20:34,700 +طيب نيجي هنا لبعض الـ Abnormalities الخاصة بالـ + +281 +00:20:34,700 --> 00:20:38,740 +White PCs لو جينا للـ Histogram هذا هنلاقي يعني + +282 +00:20:38,740 --> 00:20:41,880 +فيه حاجة غلط يعني هنا الأصل إحنا عندنا الـ + +283 +00:20:41,880 --> 00:20:45,660 +Lymphocyte تبقى مرتفعة والـ Neutrophil ما بتوصلش لـ + +284 +00:20:45,660 --> 00:20:49,650 +Flag دا وداعته لهذا الارتفاع دا بيدل على وجود الـ + +285 +00:20:49,650 --> 00:20:53,090 +Neutrophilia ارتفاع في الـ Neutrophil ولو إحنا + +286 +00:20:53,090 --> 00:20:56,230 +اطلعنا على الـ Blood Film هنشوف هذا الكلام الـ + +287 +00:20:56,230 --> 00:21:01,710 +Neutrophil عددها واضح أنه كبير إذا الارتفاع لـ + +288 +00:21:01,710 --> 00:21:05,370 +Neutrophil أدى لوجود Flag في هذه المنطقة خلينا + +289 +00:21:05,370 --> 00:21:11,250 +نشوف النسب لـ Neutrophil فعلاً 84% طبعاً هذا بيصاحبه + +290 +00:21:11,250 --> 00:21:15,210 +زي ما اتفقنا ارتفاع لـ Neutrophil هيصاحبه انخفاض + +291 +00:21:15,210 --> 00:21:18,930 +في الـ Lymphocyte نيجي للنتيجة الثانية العكس + +292 +00:21:18,930 --> 00:21:23,570 +Lymphocytosis ارتفاع في الـ Lymphocyte ارتفاع في + +293 +00:21:23,570 --> 00:21:29,550 +الـ Lymphocyte حتى يعني لو إحنا ملاحظين هنا لـ + +294 +00:21:29,550 --> 00:21:33,050 +Neutrophil كتير قليلة و الـ Peak تبعتها كتير قليلة + +295 +00:21:33,050 --> 00:21:38,750 +نسبة الـ Lymphocyte 64% و لـ Neutrophil 19 أو 19.5 + +296 +00:21:38,750 --> 00:21:40,530 +% تمام؟ + +297 +00:21:45,130 --> 00:21:49,450 +هنا نفس الشيء هنا بقولك Monocytosis طبعاً الـ + +298 +00:21:49,450 --> 00:21:53,290 +Monocyte لو ارتفعت هتعمل عند Flag في منطقة الـ Med + +299 +00:21:53,290 --> 00:21:56,270 +في المنطقة المتوسطة اللي هي بتشمل الـ Monocyte و + +300 +00:21:56,270 --> 00:21:58,870 +الـ Basophil و الـ Eosinophil هنا ارتفاع في الـ + +301 +00:21:58,870 --> 00:22:02,130 +Monocyte عمل عند Flag في هذه المنطقة نفس الشيء لو + +302 +00:22:02,130 --> 00:22:05,530 +صار ارتفاع في الـ Eosinophil هيعمل ارتفاع في منطقة + +303 +00:22:05,530 --> 00:22:07,150 +الـ Med cells + +304 +00:22:10,540 --> 00:22:15,260 +طيب نيجي لدلالة وجود كيف أستدل على وجود Nucleated + +305 +00:22:15,260 --> 00:22:19,240 +RBCs من الـ Blood Film؟ طبعاً الـ Nucleated RBCs + +306 +00:22:19,240 --> 00:22:23,980 +دلت على شيء فإنما تدل على Active Erythropoiesis صح + +307 +00:22:23,980 --> 00:22:29,780 +من يعني أنه البون مارو عمال بيشتغل بشكل كثير سريع + +308 +00:22:29,780 --> 00:22:32,940 +وكبير كبير فبالتالي بيصير يطلع الـ Nucleated RBCs + +309 +00:22:32,940 --> 00:22:35,820 +على الـ Peripheral Blood اللي هي فعلياً هذا شكلها + +310 +00:22:36,440 --> 00:22:40,400 +الـ Nucleated RBCs هي عبارة عن خلايا أصغر شوية من + +311 +00:22:40,400 --> 00:22:44,820 +حجم الـ Lymphocyte فبالتالي هتظهر لها Flag في الـ + +312 +00:22:44,820 --> 00:22:48,380 +White pieces Histogram قبل الـ Lymphocyte يعني + +313 +00:22:48,380 --> 00:22:52,060 +هتلاقي فيه هذه الـ Lymphocyte هتلاقي فيه ارتفاع + +314 +00:22:52,060 --> 00:22:56,440 +بسيط قبل الـ Lymphocyte بدل على وجود اللي هي الـ + +315 +00:22:56,440 --> 00:23:01,120 +Nucleated RBCs هيك تقريباً بنكون مرينا على الأشياء diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..90d2d16fa7d3104db4fda261c858b670ad13fc14 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_postprocess.srt @@ -0,0 +1,1260 @@ +1 +00:00:00,660 --> 00:00:05,040 +بسم الله الرحمن الرحيم إن شاء الله رب العالمين في + +2 +00:00:05,040 --> 00:00:09,560 +هذا الفيديو راح نراجع مع بعض موضوع الـ Complete + +3 +00:00:09,560 --> 00:00:14,280 +Blood Count طبعا مش هناخد احنا فحص فحص و نقرأهم و + +4 +00:00:14,280 --> 00:00:17,160 +نعرف كيف .. إيش الـ Normal و إيش الـ Abnormal و + +5 +00:00:17,160 --> 00:00:20,560 +كيف بنشغله، لأ يعني أنا اليوم بدي أجيبلكم نتائج + +6 +00:00:20,560 --> 00:00:24,920 +CBC و أركز كتير على جزئية الـ Histogram و الـ + +7 +00:00:24,920 --> 00:00:27,800 +Abnormalities اللي في الـ Histogram هذي إيش ده .. + +8 +00:00:27,800 --> 00:00:31,070 +إيش ده لإلها، إيش مدلولاتها في الـ Diagnosisيعني + +9 +00:00:31,070 --> 00:00:35,390 +كل حاجة قبل ما راح ناخدها وناخد إمتى ممكن تصيرها + +10 +00:00:35,390 --> 00:00:39,550 +لأنه يا بناتي الـCBC جزء لا يتجزأ من الـdiagnosis + +11 +00:00:39,550 --> 00:00:43,350 +للأنيميا من الأشياء المهمة جدا عشان أعرف أعمل + +12 +00:00:43,350 --> 00:00:48,730 +diagnosis جيد للأنيميا أني أعرف أقرأ إيه نيجي + +13 +00:00:48,730 --> 00:00:52,430 +لجزئية الـhistogram ونحاول نفهم أو نراجع مع بعض + +14 +00:00:52,430 --> 00:00:55,900 +إيش هو الـhistogramطبعا بالإضافة للـ Parameters + +15 +00:00:55,900 --> 00:00:59,000 +اللي بتلاقيها مكتوبة في الـ CPC اللي هو عدل الـ + +16 +00:00:59,000 --> 00:01:01,740 +White PCs و الـ RBCs و الـ Platelets و الـ Blood + +17 +00:01:01,740 --> 00:01:05,800 +Indices هتلاقي عندك الـ Histograms هتلاقي عندك + +18 +00:01:05,800 --> 00:01:09,840 +تلاتة Histogram واحد خاص في الـ Platelets واحد خاص + +19 +00:01:09,840 --> 00:01:14,870 +بالـ RBCs واحد خاص بالـ White PCsالـ Figure هذا + +20 +00:01:14,870 --> 00:01:19,550 +اللي عندنا يعني حاول إنه يحط التلاتة histogram مع + +21 +00:01:19,550 --> 00:01:25,530 +بعض عشان يورجيكي كمقارنة يعني عامل ما بين الأحجام + +22 +00:01:25,530 --> 00:01:28,690 +بتاعة الخلايا حسب ما بيعدها الجهاز طبعا إحنا + +23 +00:01:28,690 --> 00:01:33,030 +عارفين إنه الجهاز بيعد الخلايا على حسب أحجامها + +24 +00:01:33,030 --> 00:01:37,570 +يعني مثلا بيعرف هذه Platelet في حجم معين بيعده إنه + +25 +00:01:37,570 --> 00:01:41,270 +Platelet إذا كانت من 2 إلى 20 مثلا بيعدها Platelet + +26 +00:01:41,700 --> 00:01:46,520 +من 36 إلى 360 بعيدها الـ Erythrocyte فيم توليتر + +27 +00:01:46,520 --> 00:01:51,220 +اللي هو الـ Diameter بتاع الخلية و هكذا طبعاً + +28 +00:01:51,220 --> 00:01:55,180 +الرسمها دي إيش مدلولها أو على إيش بتدل هنا عندي + +29 +00:01:55,180 --> 00:02:01,630 +حجم الخلية فده حجم الخلية تمام هناالـ Frequency + +30 +00:02:01,630 --> 00:02:05,690 +تاعها يعني مثلًا بالنسبة للـ Platelet هذا الـ + +31 +00:02:05,690 --> 00:02:08,510 +Curve تاع الـ Platelet على سبيل المثال طلع معايا + +32 +00:02:08,510 --> 00:02:11,470 +هكذا هذا يوضح الـ Frequency للـ Platelet يعني + +33 +00:02:11,470 --> 00:02:16,290 +مثلًا عد عندي خلايا أربعة فمتو لتر الخلية حجمها + +34 +00:02:16,290 --> 00:02:20,570 +أربعة فمتو لتر هنا أداش في عندي خلايا أربعة فمتو + +35 +00:02:20,570 --> 00:02:24,470 +لتر خمسة فمتو لتر و هكذا يعني هنا بيبينلي حجم + +36 +00:02:24,470 --> 00:02:28,410 +الخلية وهنا بيبينلي ال frequency تاع الخلية هذه + +37 +00:02:29,340 --> 00:02:33,980 +طبعاً برضه إذا كنا فاكرين إن الـ Platelets و الـ + +38 +00:02:33,980 --> 00:02:38,000 +Erythrocyte بنعدوا على نفس الشمبر في نفس الشمبر، + +39 +00:02:38,000 --> 00:02:41,820 +يعني في نفس المكان بس بيميز بينهم الجهاز على حسب + +40 +00:02:41,820 --> 00:02:48,920 +حجم الخلايا بينما الـ YPCs بتدخل في مسار تاني + +41 +00:02:48,920 --> 00:02:52,480 +بتقرأ هي و الـ Hemoglobin بحيث بيصير License للـ + +42 +00:02:52,480 --> 00:02:56,940 +RPCsوبتظل عندى بس الـ white pieces بتم عد الـ + +43 +00:02:56,940 --> 00:03:00,140 +white pieces برضه بنفس الطريقة على حسب أحجامها + +44 +00:03:00,140 --> 00:03:06,220 +تصنف إلى lymphocyte وإلى mid وgranulocyte وبعد هيك + +45 +00:03:06,220 --> 00:03:11,160 +في نفس الشمبر بتم قراءة الهيموجلوبين باستخدام كتبة + +46 +00:03:11,160 --> 00:03:14,620 +الـ photometry يعني بتمرير ضوء معين وقياس ال + +47 +00:03:14,620 --> 00:03:19,310 +absorbance وبحسب للجهاز الهيموجلوبينإذاً هذه + +48 +00:03:19,310 --> 00:03:23,790 +الرسمة هو دامش فيها التلاتة Histogram مع بعض إحنا + +49 +00:03:23,790 --> 00:03:27,570 +في الـCBC بنشوف كل واحدة لحال البلاترف لحال + +50 +00:03:27,570 --> 00:03:33,030 +والـRBCs لحال والـWhite PCs لحال المرحلة اللي بعد + +51 +00:03:33,030 --> 00:03:36,330 +هيك حنا خد واحد واحد ونشوف الـAbnormalities اللي + +52 +00:03:36,330 --> 00:03:39,610 +ممكن تسير في الـCurve وانا كيف لما أشوفها في + +53 +00:03:39,610 --> 00:03:43,210 +الـHistogram كيف أنا ممكن أستدل من خلالها على وجود + +54 +00:03:43,210 --> 00:03:49,380 +خلل معين أو حالة مرضية معينةهذا رسم يعني لأ مش + +55 +00:03:49,380 --> 00:03:53,180 +بالشرط يكون رسم صحيح يعني الـ Platelets في + +56 +00:03:53,180 --> 00:03:56,180 +Instagram ما بيكون شكله هيك والـ Granulocyte برضه + +57 +00:03:56,180 --> 00:04:00,280 +هنا ما بتكون هيك يعني بس هو كرسم تخطيطي عشان هذا + +58 +00:04:00,280 --> 00:04:04,060 +الهدف منه أنه يبينلك المقارنة بين أحجام الخلايا + +59 +00:04:04,060 --> 00:04:08,060 +يعني أصغر حاجة لـPlatelets هلأ الـRBCs بعد هيك + +60 +00:04:08,060 --> 00:04:11,180 +الـLymphocyte بتيجي تقريبا قريبة من الـRBCs + +61 +00:04:11,180 --> 00:04:16,390 +والـMed Cellsوالـ mid-cells بعد هيك للـ + +62 +00:04:16,390 --> 00:04:20,970 +granulocyte طيب + +63 +00:04:20,970 --> 00:04:24,970 +نيجي هنا للهيستوجرام بتاع الـ platelets وتاع + +64 +00:04:24,970 --> 00:04:30,710 +الاريثرocyte عند البلاتلت بتنعد تقريبا من 2 إلى 20 + +65 +00:04:30,710 --> 00:04:34,840 +أو إلى 25 بعيدها الجهاز على إنها plateletsأيه بعد + +66 +00:04:34,840 --> 00:04:37,900 +هيك بيصير انخفاض في ال care في ال histogram وبيبلش + +67 +00:04:37,900 --> 00:04:41,180 +يطلع اللي هو بتاع ال RBCs احنا ماهنشوفهم هيك في ال + +68 +00:04:41,180 --> 00:04:45,080 +histogram في ال CBC احنا هنشوف كل واحد لحال لكن هم + +69 +00:04:45,080 --> 00:04:48,000 +فعليا يعني بتيجي ال blessed و بتخلص بعد هيك + +70 +00:04:48,000 --> 00:04:51,700 +التدائل erythrocyteهلاقيت لو أجينا للـ Histogram + +71 +00:04:51,700 --> 00:04:56,440 +مثلا لـ Platelet الـ Platelet متوسط حجمها من 8 إلى + +72 +00:04:56,440 --> 00:05:00,880 +12 فهتلاقي أكتر ارتفاع من 8 إلى 12 لماذا؟ لأن معظم + +73 +00:05:00,880 --> 00:05:04,320 +الخلايا هتقع في الـ Normal Range صح؟ لشان هيك هو + +74 +00:05:04,320 --> 00:05:07,520 +أخد هذا المنظر أكتر accumulation أو أكتر + +75 +00:05:07,520 --> 00:05:11,630 +percentage للخلايا هتلاقيها في هذه المنطقةنفس + +76 +00:05:11,630 --> 00:05:15,410 +الأشي بالنسبة للـ RBCs هتلاقي الارتفاع في منطقة + +77 +00:05:15,410 --> 00:05:19,190 +الـ MCV الـ Normal من 8 إلى 100، من 80 إلى 100 هذا + +78 +00:05:19,190 --> 00:05:24,240 +إذا كانت العينة طبعا Normalهتلاقي فيه تقريبًا + +79 +00:05:24,240 --> 00:05:28,680 +تطابق مع الـ MCV مع الـ Peak يعني وين الـ Peak + +80 +00:05:28,680 --> 00:05:33,200 +بتاعة الـ Histogram هتلاقيها تقريبًا نفسها هي الـ + +81 +00:05:33,200 --> 00:05:36,820 +MCV ليش؟ لأن الـ MCV هي الـ Main Volume بتاع + +82 +00:05:36,820 --> 00:05:41,080 +الخلايا المتوسط، متوسط حجم الخلايا وأكيد القيمة + +83 +00:05:41,080 --> 00:05:45,140 +المتوسطة ده الـ Average عادةً هو يمثل أكثر القيم + +84 +00:05:45,140 --> 00:05:48,380 +اضطرارًا في الـ Curve، تمام؟ + +85 +00:06:00,260 --> 00:06:04,700 +هنا الـ white pieces histogram هلأ في الـ white + +86 +00:06:04,700 --> 00:06:09,380 +pieces histogram بيوضّح عندك ال .. ال .. ال peaks + +87 +00:06:09,380 --> 00:06:13,360 +التلاتة في عندي الـ lymphocyte هذه أول peak لأن + +88 +00:06:13,360 --> 00:06:16,600 +أصغر حجم خلايا هي الـ lymphocyte بعد هيك بتيجي + +89 +00:06:16,600 --> 00:06:20,480 +عندي الـ monocyte والبازوفيل والإزينوفيل بعد هيك + +90 +00:06:20,480 --> 00:06:26,480 +لـ neutrophilالآن السؤال اللي بترح نفسه أنه يعني + +91 +00:06:26,480 --> 00:06:29,360 +إحنا بنعرف إنه الـ Monocyte أكبر من الـ Neutrophil + +92 +00:06:29,360 --> 00:06:33,740 +مثلا طيب ليش الـ Neutrophil اعتبرها الجهاز أكبر؟ + +93 +00:06:33,740 --> 00:06:36,520 +إذا كنتوا فاكرين الـ Principle تاعة قراءة القراءة + +94 +00:06:36,520 --> 00:06:41,900 +تاعة الـ White PCs قلنا إنه الجهاز بياخد الخلايا + +95 +00:06:41,900 --> 00:06:46,060 +بيعمل لها بيعمل للـ RBC slicing في الشمبر تاع الـ + +96 +00:06:46,060 --> 00:06:50,000 +White PCsونفس المحلول الـ Lysing Reagent اللي أنا + +97 +00:06:50,000 --> 00:06:54,200 +بحطه بعمل Shrinking للـ White BCs يعني بعمل + +98 +00:06:54,200 --> 00:06:59,500 +Collapse للخلية حوالين النواء فبالتالي بيصير حجم + +99 +00:06:59,500 --> 00:07:05,560 +الـ Cytoplasm لا قيمة له وبتم العد الحقيقي حسب حجم + +100 +00:07:05,560 --> 00:07:10,320 +النواء عشان هيك لـ Neutrophil إن عدت علي إنها أكبر + +101 +00:07:10,320 --> 00:07:15,090 +واحدةوهدول كلهم بيعدهم ضمن الـ mid-region اللي هي + +102 +00:07:15,090 --> 00:07:21,330 +الـ monocyte والبازوفيل والإزينوفيل خلّيني أنا أخد + +103 +00:07:21,330 --> 00:07:25,170 +بعض الأمثلة اللي يعني نحط فيها بعض صور الـ + +104 +00:07:25,170 --> 00:07:31,190 +histogram ونحاول نشوف إيش دلالتها عندي هنا two + +105 +00:07:31,190 --> 00:07:38,970 +CBCs والتانية اللي لهم علاقة بالأنميا لكن يعني في + +106 +00:07:38,970 --> 00:07:44,360 +فرق في ال diagnosisبس اشتراك في الـ category بتاعة + +107 +00:07:44,360 --> 00:07:48,600 +الانيمي خلينا نفهم إيش الكلام اللي بقوله الآن لو + +108 +00:07:48,600 --> 00:07:56,020 +إجينا نبطلع على ال histogram أول حاجة راح نلاحظها + +109 +00:07:56,020 --> 00:08:03,750 +إن ال RBCs histogram صيرله شوية shift to leftيعني + +110 +00:08:03,750 --> 00:08:08,890 +الـ Peak مفروض تكون ما بين 80 إلى 100 لكن هنا الـ + +111 +00:08:08,890 --> 00:08:14,190 +Peak لأ تقريبا عند بين الـ 60 والـ 70 طيب على إيش + +112 +00:08:14,190 --> 00:08:19,870 +بدل هذا؟ على إنه حجم الخلايا صغير والتاني نفس + +113 +00:08:19,870 --> 00:08:24,590 +الاشي الـ Histogram إنه صاير Shift to Lift لو + +114 +00:08:24,590 --> 00:08:29,110 +أجينا نتطلع على الـ MCV فعلا هنلاقي إن الـ MCV + +115 +00:08:29,110 --> 00:08:35,260 +منخفضة في التنين هنا 65وفي التاني 68 وهذا اللي عمل + +116 +00:08:35,260 --> 00:08:39,920 +إزاحة للـ Histogram إلى جهة اليسار إزاحة لليسار + +117 +00:08:39,920 --> 00:08:45,040 +يعني الخلايا الـ Microcytic طيب، هذا برضه راح يأثر + +118 +00:08:45,040 --> 00:08:49,080 +عندي على الـ Platelet Histogram لأنه هيكون في عندي + +119 +00:08:49,080 --> 00:08:53,830 +RBCs صغيرةهتظهر في الـ Area ما بين الـ Platelet + +120 +00:08:53,830 --> 00:08:57,450 +Histogram و الـ Erythrocyte Histogram وهذا اللي + +121 +00:08:57,450 --> 00:09:01,170 +ظاهر فعليًا في الـ Platelet Histogram زي ما انتوا + +122 +00:09:01,170 --> 00:09:04,510 +شايفين لو أجينا نطلع على الـ Platelet Histogram + +123 +00:09:04,510 --> 00:09:09,370 +المفروض ينزل لـ Platelet Histogram لكن في عند هنا + +124 +00:09:09,370 --> 00:09:13,570 +شوية ارتفاع ما بين الـ Platelet Histogram و الـ + +125 +00:09:13,570 --> 00:09:17,950 +Erythrocyte Histogramطبعاً إذا دل على شيء هذا يدل + +126 +00:09:17,950 --> 00:09:23,630 +على إنه في عندي أشياء حجمها متوسط ما بين الـ + +127 +00:09:23,630 --> 00:09:28,650 +Platelets و الـ Erthrocytes عيننا هنا يتضح إنه هي + +128 +00:09:28,650 --> 00:09:33,070 +عبارة عن Microcytic Erthrocytes لأن الـ MCV قليل + +129 +00:09:33,070 --> 00:09:37,930 +طيب هنا لو أجينا نشوف ال diagnosis هنلاقي ال + +130 +00:09:37,930 --> 00:09:42,430 +diagnosis هنا Iron Deficiency Anemia بينما هنا ال + +131 +00:09:42,430 --> 00:09:47,870 +diagnosis Suspectedثلاثيمية طيب خلّينا نشوف لو + +132 +00:09:47,870 --> 00:09:53,210 +أجينا للـRBCs للـCBC عفواً في الـIron Deficiency + +133 +00:09:53,210 --> 00:09:57,350 +أنيمية هنلاقي الـRBCs منخفضة والثلاثيمية هنلاقيها + +134 +00:09:57,350 --> 00:10:03,210 +مرتفعة شغلة تانية لو أجينا يعني الـMCV أحياناً + +135 +00:10:03,210 --> 00:10:06,030 +كتير في الثلاثيمية بيكون تحت السبعين بينما + +136 +00:10:06,030 --> 00:10:09,630 +بالـIron Deficiency بيكون فوق السبعينوإن كان هنا + +137 +00:10:09,630 --> 00:10:13,350 +التنين في تشابه بينهم التنين تحت السبعين فبالتالي + +138 +00:10:13,350 --> 00:10:21,450 +هذا ما فصل عندي بين التنتين اللي هو الـ MCV نيجي + +139 +00:10:21,450 --> 00:10:27,290 +لحاجة مهمة كتير اللي هي الـ RDW الـ RDW عادة تدل + +140 +00:10:27,290 --> 00:10:31,460 +على درجة الـ variation في أحجام الخلاياوهذه الـ + +141 +00:10:31,460 --> 00:10:35,480 +RDW يعني من الأشياء المهمة جدًا اللي بنفرق من + +142 +00:10:35,480 --> 00:10:38,900 +خلالها ما بين الثلاثيميا والـ Iron Deficiency + +143 +00:10:38,900 --> 00:10:42,240 +Anemia هنا في الـ Iron Deficiency Anemia هنلاقيه + +144 +00:10:42,240 --> 00:10:44,940 +مرتفع لأنه في الـ Iron Deficiency الخلايا بيكون + +145 +00:10:44,940 --> 00:10:48,480 +فيه variation في أحجامها بينما في الثلاثيميا + +146 +00:10:48,480 --> 00:10:54,020 +هنلاقيه تقريبًا Normal اللي هو 14.7% مما يدل على + +147 +00:10:54,020 --> 00:10:58,520 +أنه فيه تقارب صحي الخلايا الصغيرة لكن فيه تقارب في + +148 +00:10:58,520 --> 00:11:02,780 +أحجام الخلاياإذا الحالتين لنفس الكاتيجوريا + +149 +00:11:02,780 --> 00:11:06,940 +Microcytic Hypochromic Anemia Microcytosis and + +150 +00:11:06,940 --> 00:11:12,340 +Hypochromia وهذه التنتين كان في .. إيش ال + +151 +00:11:12,340 --> 00:11:15,700 +diagnosis؟ هو بقولك هنا دي Suspected Thalassemia + +152 +00:11:15,700 --> 00:11:19,500 +طبعاً بنعمل confirmation ب Hemoglobin A2 and + +153 +00:11:19,500 --> 00:11:21,220 +Hemoglobin Electrophoresis + +154 +00:11:23,120 --> 00:11:27,760 +بنجي لصورة تانية بتجمع ما بين الـ Histogram بتاع + +155 +00:11:27,760 --> 00:11:32,320 +الـ RBCs و بتاع الـ YPCs خلّينا أول حاجة ناخد هذا + +156 +00:11:32,320 --> 00:11:36,360 +الـ Histogram هنا عند الـ Histogram لو أجينا نطلع + +157 +00:11:36,360 --> 00:11:41,040 +هنلاقيه Bimodal بقولك هذه الحالة عبارة عن Iron + +158 +00:11:41,040 --> 00:11:45,550 +deficiency anemia under treatmentيعني بداية كانت + +159 +00:11:45,550 --> 00:11:50,030 +الخلايا Microcytic لكن لما بلش المريض بلشت تظهر + +160 +00:11:50,030 --> 00:11:54,190 +عندى كاتيجورى تانية من الخلايا اللى هى Normocytic + +161 +00:11:54,190 --> 00:12:01,770 +فصار عندى الـ Histogram بايمودلبعد أربع أسابيع من + +162 +00:12:01,770 --> 00:12:06,810 +العلاج لو نزلنا لتحت بالصورة هنلاحظ إنه بلشت + +163 +00:12:06,810 --> 00:12:10,570 +الخلايا اللي حجمها طبيعي ترتفع وتصير أكتر من + +164 +00:12:10,570 --> 00:12:14,950 +الخلايا الـ Microcytic هذا بيدل على إنه في استجابة + +165 +00:12:14,950 --> 00:12:18,810 +في العلاج طبعا لو أجينا إحنا نتطلع على الـ + +166 +00:12:18,810 --> 00:12:22,910 +Histogram هنلاقي الـ Histogram هنا صار عندي واسع + +167 +00:12:22,910 --> 00:12:29,070 +أو عريض كتير هذا أكيد الـ RDW لإله هتكون عاليةالـ + +168 +00:12:29,070 --> 00:12:34,150 +RDW بالمفهوم البسيط هي الـ Variation بين أحجام + +169 +00:12:34,150 --> 00:12:39,850 +الخلايا وممكن لو طلعنا على الـ Histogram ناخد فكرة + +170 +00:12:39,850 --> 00:12:45,790 +عن وضع الـ RDW لأنها ببساطة Red Distribution Curve + +171 +00:12:45,790 --> 00:12:49,420 +Widthيعني هذا الـ Curve بتاع الـ Erythrocyte قداش + +172 +00:12:49,420 --> 00:12:52,840 +الـ Width بتاعه، قداش العرض أو قداش الاتساع بتاع + +173 +00:12:52,840 --> 00:12:56,520 +الـ Curve فكل ما كان الـ Curve أعرض، دال على إنه + +174 +00:12:56,520 --> 00:13:02,580 +فيه تباين أكتر للخلايا وكل ما دال على إنه الـ RDW + +175 +00:13:02,580 --> 00:13:06,380 +مرتفع أكتر، إذن هذه حالة Iron Deficiency Anemia + +176 +00:13:06,380 --> 00:13:10,890 +Under Treatmentطيب، نيجي للحالة التانية اللي على + +177 +00:13:10,890 --> 00:13:13,730 +الجهة التانية من الـ slide اللي هي الـ Macrocytic + +178 +00:13:13,730 --> 00:13:19,210 +Anemia وهي بقولك حالة CML طبعاً خلينا ناخدهم واحدة + +179 +00:13:19,210 --> 00:13:22,790 +واحدة الـ RBCs Histogram لحال والـ White BCs + +180 +00:13:22,790 --> 00:13:25,870 +Histogram لحال أول حاجة هو حاكي عن الـ White BCs + +181 +00:13:25,870 --> 00:13:29,370 +Histogram طبعاً إحنا بنعرف إن الـ White BCs + +182 +00:13:29,370 --> 00:13:32,710 +Histogram في تلاتة فلاج الأولى اللي هي الـ + +183 +00:13:32,710 --> 00:13:37,420 +lymphocyteالتانية الـ Med التالتة لـ Granulocyte + +184 +00:13:37,420 --> 00:13:41,240 +أو اللي هي لـ Neutrophil هنا هنلاحظ ارتفاع في + +185 +00:13:41,240 --> 00:13:44,960 +منطقة الـ Med فهذا بيدل على وجود Immature + +186 +00:13:44,960 --> 00:13:48,880 +Granulocyte بكل أنواعها، ممكن تكون Myelocyte، + +187 +00:13:48,880 --> 00:13:52,480 +Metamyelocyte وانتوا عارفين الـCML بيبقى فيها + +188 +00:13:52,480 --> 00:13:57,420 +Abnormal Cells اللي هي Immature Stages من الـ + +189 +00:13:57,420 --> 00:14:01,440 +Granulocyte فهي ظهرت في الـ Histogram في هذه + +190 +00:14:01,440 --> 00:14:08,260 +المنطقةالشغل التاني اللي بدنا نحكيها اللي هي بخصوص + +191 +00:14:08,260 --> 00:14:14,700 +الـ RBCs Histogramلو لاحظنا هنلاقي إن الـ + +192 +00:14:14,700 --> 00:14:18,280 +Erythrocyte هستجرام سيرله Shift لفت يعقف عن Shift + +193 +00:14:18,280 --> 00:14:23,080 +Right يعني الـ Curve كله اتحرك إلى جهة اليمين هذا + +194 +00:14:23,080 --> 00:14:27,200 +إذا دل على شيء بيدل على إن الخلايا حجمها كبير طيب + +195 +00:14:27,200 --> 00:14:31,320 +نشوف الـ MCV هل الخلايا فعلا حجمها كبير فعلا + +196 +00:14:31,320 --> 00:14:39,680 +الخلايا كبيرة 110 فمتو لتر فبالتالي استنتاجنا كان + +197 +00:14:39,680 --> 00:14:46,650 +صحيحطيب نيجي هنا لحالات يعني متفرقة هنا بقولك حالة + +198 +00:14:46,650 --> 00:14:51,490 +Anesocytosis يعني في عندي Variation بالـ RBCs Size + +199 +00:14:51,490 --> 00:14:55,950 +أكتر حاجة بلاحظها، بنات احنا ممكن هنا ألاحظ أن الـ + +200 +00:14:55,950 --> 00:15:00,010 +MCV تقريبًا تقريبًا يعني With الـ Normal Range على + +201 +00:15:00,010 --> 00:15:03,270 +ال Upper Limit الـ Normal احنا قولنا من 80 لـ 97 + +202 +00:15:03,270 --> 00:15:07,650 +أعلى شوية من الـ Normal يعني الخلايا حجمها أكبر + +203 +00:15:07,650 --> 00:15:12,700 +شوية لكن الأكثر، الحاجة الملحوظة أكثرإنه فيه تباين + +204 +00:15:12,700 --> 00:15:17,240 +كتير كبير في حجم الخلايا دليل هيك إنه شايفين الـ + +205 +00:15:17,240 --> 00:15:22,020 +Histogram أداش واسع من هذه المنطقة طبعاً اتساع الـ + +206 +00:15:22,020 --> 00:15:26,060 +Histogram بيدل على إنه الـ RDW عالي وإنه فيه تباين + +207 +00:15:26,060 --> 00:15:33,080 +كبير بين أحجام الخلايا طب نشوف الـ RDW 22.7% صحيح + +208 +00:15:33,080 --> 00:15:37,080 +الكلام، إذن في عندى Variation في أحجام الخلايا + +209 +00:15:37,080 --> 00:15:42,400 +كبيرةوهذا نفس الفكرة عندنا لو لاحظنا هنلاقي الـ + +210 +00:15:42,400 --> 00:15:49,760 +MCV مرتفعة والـ RDW برضه 26 وهذا طبعاً استدلان + +211 +00:15:49,760 --> 00:15:57,520 +عليه كمان من خلال اتساع الـ Histogram نيجي + +212 +00:15:57,520 --> 00:16:00,680 +لهنا حاجة خاصة بالـ Curve بتاع الـ Platelet أو + +213 +00:16:00,680 --> 00:16:04,200 +بالـ Histogram بتاع الـ Platelet هنا لو لاحظنا + +214 +00:16:04,200 --> 00:16:11,830 +هنلاقي الـ Histogramعريض شوية بالإضافة بالإضافة + +215 +00:16:11,830 --> 00:16:15,710 +مثلا في عندي في ال «Castle» في عندي في هذه المنطقة + +216 +00:16:15,710 --> 00:16:19,670 +ارتفاع في فلاج في هذه المنطقة في عندي هنا حاجة + +217 +00:16:19,670 --> 00:16:24,010 +بيسموها «Percent of Large Cells» أو «Percent of + +218 +00:16:24,010 --> 00:16:26,510 +Large Platelets» هذا بيبين عندي نسبة قداش في عندي + +219 +00:16:26,510 --> 00:16:30,890 +«Giant Platelets» هنا عندي 44% يعني نسبة عالية من + +220 +00:16:30,890 --> 00:16:34,620 +الـ «Giant Platelets»Blatelet Distribution Width + +221 +00:16:34,620 --> 00:16:37,860 +برضه الـ Distribution Width للـ Blatelets زي و زي + +222 +00:16:37,860 --> 00:16:41,200 +الـ Distribution Width للـ RBCs بيبين عندي قداش + +223 +00:16:41,200 --> 00:16:44,600 +فيه تباين بأحجام الـ Blatelets عندي برضه هنا هي + +224 +00:16:44,600 --> 00:16:48,550 +أعطاني Flag إنه مرتفع عالي زي ما أنتوا تفكرونواللي + +225 +00:16:48,550 --> 00:16:52,310 +دلّل عندى هنا على وجود Giant Platelets وجود الـ + +226 +00:16:52,310 --> 00:16:55,770 +Curve هنا فيه يعني مش نازل زي ما احنا متعودين هو + +227 +00:16:55,770 --> 00:16:59,790 +من 6 إلى 8 وبينزل لكن عندى هنا في هذه الحالة Case + +228 +00:16:59,790 --> 00:17:02,330 +2 زي ما انتوا ملاحظين كتير هذه واضحة انه Large + +229 +00:17:02,330 --> 00:17:06,510 +Platelets وبأحجام متباينة والـ Curve عند نهايته + +230 +00:17:06,510 --> 00:17:10,950 +هنا ما نزل يعني ضل الـ Curve مرتفع دليل على وجود + +231 +00:17:10,950 --> 00:17:15,790 +Platelets وشبك مع الـ RBCs Testogram يعني ممكن حتى + +232 +00:17:15,790 --> 00:17:17,450 +هنا يكون فيه Large Platelets + +233 +00:17:20,570 --> 00:17:25,310 +هنا نيجي للـ Platelet Aggregation كيف ممكن تظهر + +234 +00:17:25,310 --> 00:17:29,730 +الـ Platelet Aggregation ممكن تظهر معايا على شكل + +235 +00:17:29,730 --> 00:17:32,910 +إنه الـ Curve برضه ما انتهاش يعني لأنه الـ + +236 +00:17:32,910 --> 00:17:38,150 +Platelet Aggregate هتنعد على إنه كل مجموعة من الـ + +237 +00:17:38,150 --> 00:17:41,950 +Aggregate هتنعد على إنها Large Platelet فهيكون وضع + +238 +00:17:41,950 --> 00:17:44,910 +الـ Histogram شبيه بوضع الـ Giant أو Large + +239 +00:17:44,910 --> 00:17:49,760 +Plateletالـ Platelet Aggregates هتظهر مع الـ White + +240 +00:17:49,760 --> 00:17:53,080 +BCs كمان يعني هيظهر في عندي Flag قبل الـ + +241 +00:17:53,080 --> 00:17:56,120 +Lymphocyte في هذه المنطقة في الـ Histogram بتاع + +242 +00:17:56,120 --> 00:17:59,740 +الـ White BCs إذا ظهر معايا احتمال يكون وجود + +243 +00:17:59,740 --> 00:18:03,080 +Platelet Aggregate هاي واضح في Case 1 وفي Case 2 + +244 +00:18:03,080 --> 00:18:06,680 +إنه الـ Curve ضلوا في البلاتلت مرتفع Curve + +245 +00:18:06,680 --> 00:18:09,500 +البلاتلت ضلوا مرتفع هنا زي ما انتوا شايفين + +246 +00:18:09,500 --> 00:18:13,710 +ماانتهاشبيقول نفس الأشي ظهرت عندي Flag في curve + +247 +00:18:13,710 --> 00:18:17,790 +الـ RBCs أو الـ Histogram تاع الـ … عفوا، عفوا، + +248 +00:18:17,790 --> 00:18:21,510 +ظهر هنا Flag في الـ Histogram تاع الـ White Pisces + +249 +00:18:25,290 --> 00:18:29,010 +وجود Cold Agglutinane Cold Agglutinane يعني + +250 +00:18:29,010 --> 00:18:32,790 +Irregular Agglutination للخلايا يعني هتلاقي في + +251 +00:18:32,790 --> 00:18:36,990 +عندنا Variation في الـ Size في خلايا خلية لحالة في + +252 +00:18:36,990 --> 00:18:40,750 +تنتين في تلاتة يعني كأنه أنا بحكي عن Anesocytosis + +253 +00:18:40,750 --> 00:18:44,850 +بال picture هنابالـ Picture هيكون عندى الـ RDW + +254 +00:18:44,850 --> 00:18:48,450 +عالية ليش؟ لأنه فيه تباين فيه خليتان وفيه تلاتة + +255 +00:18:48,450 --> 00:18:52,510 +اتجمعوا فيه أكتر من هيك فبالتالي كل مجموعة هتنعد + +256 +00:18:52,510 --> 00:18:57,790 +على أنها خلية ذات حجم خاص فهذا هيعطيني إشارة على + +257 +00:18:57,790 --> 00:19:02,530 +أنه فيه تباين بأحجام الخلايا ويبقى الـ RDW مرتفع + +258 +00:19:02,530 --> 00:19:06,790 +زي ما إحنا شايفين هناهي لو لاحظنا هي الـ Curve + +259 +00:19:06,790 --> 00:19:11,150 +والـ Curve برضه لو لاحظنا برضه الـ MCV مرتفعة لأن + +260 +00:19:11,150 --> 00:19:14,810 +الخلايا بدل ما تكون عدد واحدة واحدة هنصير عدة + +261 +00:19:14,810 --> 00:19:18,430 +جمعات كبيرة مما يزيد من الـ MCV إذا الـ Curve + +262 +00:19:18,430 --> 00:19:22,410 +صيرله Shift to Right بعدين في عند فلاج وجود دليل + +263 +00:19:22,410 --> 00:19:25,450 +على وجود يعني أنه ما خلص الـ Curve دليل على أنه في + +264 +00:19:25,450 --> 00:19:28,630 +خلايا كبيرة هنا الخلايا الكبيرة هنا فعليًا هي + +265 +00:19:28,630 --> 00:19:32,980 +عبارة عن Cold Agglutinateهنا بقولك تجربة حلوة إحنا + +266 +00:19:32,980 --> 00:19:36,380 +بعد ما عملنا نفس العينة عملنا لها Incubation + +267 +00:19:36,380 --> 00:19:40,560 +تلاتين دقيقة في سبعة وتلاتين درجة عشان نفكك الـ + +268 +00:19:40,560 --> 00:19:43,300 +Agglutination وعملنا منها فيلم وعملنا منها CBC + +269 +00:19:43,300 --> 00:19:46,480 +طلعت معانا النتيجة اللي على الجهة هذه نشوف إيش طلع + +270 +00:19:46,480 --> 00:19:49,840 +معانا أول حاجة الـ Blood Film صار Normal كان + +271 +00:19:49,840 --> 00:19:53,800 +بالأول فيه Agglutinates لكن هنا صار عندي Normal + +272 +00:19:53,800 --> 00:19:58,100 +الشغلة التانية المهمة لو إجينا للـ Histogram + +273 +00:19:58,100 --> 00:20:03,460 +هنلاقي الـ Histogram صار طبيعيكمان الـ MCV انخفضت + +274 +00:20:03,460 --> 00:20:07,180 +كانت هنا 111 بالأول قبل ما أعمل Incubation كانت + +275 +00:20:07,180 --> 00:20:11,780 +111، هنا صارت 100، ليش؟ لأن الـ Large Aggregates + +276 +00:20:11,780 --> 00:20:16,760 +اتفككت إلى حد ما وعطتني Normal Result أو Normal + +277 +00:20:16,760 --> 00:20:21,120 +Reading، بعدين الـ Flag اللي ظهرت في نهاية عدد تل + +278 +00:20:21,120 --> 00:20:24,580 +تاع الـ Histogram ما ظهرت بعد الـ Incubation، دليل + +279 +00:20:24,580 --> 00:20:27,100 +على أن الأجلوتينيات اتفككت + +280 +00:20:31,160 --> 00:20:34,700 +طيب نيجي هنا لبعض الـ Abnormalities الخاصة بالـ + +281 +00:20:34,700 --> 00:20:38,740 +White PCs لو جينا للـ Histogram هذا هنلاقي يعني + +282 +00:20:38,740 --> 00:20:41,880 +فيه حاجة غلط يعني هنا الأصل احنا عندنا الـ + +283 +00:20:41,880 --> 00:20:45,660 +lymphocyte تبقى مرتفعة والـ neutrophil مابتوصلش لـ + +284 +00:20:45,660 --> 00:20:49,650 +Flag داعتها لهذا الارتفاعها دا بيدل على وجود الـ + +285 +00:20:49,650 --> 00:20:53,090 +Neutrophilia ارتفاع في الـ Neutrophil ولو احنا + +286 +00:20:53,090 --> 00:20:56,230 +اطلعنا على الـ Blood Film هنشوف هذا الكلام الـ + +287 +00:20:56,230 --> 00:21:01,710 +Neutrophil عددها واضح انه كبير اذا الارتفاع لـ + +288 +00:21:01,710 --> 00:21:05,370 +Neutrophil أدى لوجود Flag في هذه المنطقة خلينا + +289 +00:21:05,370 --> 00:21:11,250 +نشوف النسب لـ Neutrophil فعلا 84% طبعا هذا بيصاحبه + +290 +00:21:11,250 --> 00:21:15,210 +زي ما اتفقنا ارتفاع لـ Neutrophil هيصاحبه انخفاض + +291 +00:21:15,210 --> 00:21:18,930 +في الـ lymphocyteنيجي للنتيجة التانية العكس + +292 +00:21:18,930 --> 00:21:23,570 +Lymphocytosis ارتفاع في الـ Lymphocyte ارتفاع في + +293 +00:21:23,570 --> 00:21:29,550 +الـ Lymphocyte حتى يعني لو احنا ملاحظين هنا لـ + +294 +00:21:29,550 --> 00:21:33,050 +Neutrophil كتير قليلة و الـ Peak تبعتها كتير قليلة + +295 +00:21:33,050 --> 00:21:38,750 +نسبة الـ Lymphocyte 64% و لـ Neutrophil 19 أو 19.5 + +296 +00:21:38,750 --> 00:21:40,530 +% تمام؟ + +297 +00:21:45,130 --> 00:21:49,450 +هنا نفس الأشي هنا بقولك Monocytosis طبعا الـ + +298 +00:21:49,450 --> 00:21:53,290 +Monocyte لو ارتفعت هتعمل عند فلاج في منطقة الـ Med + +299 +00:21:53,290 --> 00:21:56,270 +في المنطقة المتوسطة اللي هي بتشمل الـ Monocyte و + +300 +00:21:56,270 --> 00:21:58,870 +الـ Basophil و الـ Azenophil هنا ارتفاع في الـ + +301 +00:21:58,870 --> 00:22:02,130 +Monocyte عمل عند فلاج في هذه المنطقة نفس الأشي لو + +302 +00:22:02,130 --> 00:22:05,530 +صار ارتفاع في الـ Azenophil هيعمل ارتفاع في منطقة + +303 +00:22:05,530 --> 00:22:07,150 +الـ Med cells + +304 +00:22:10,540 --> 00:22:15,260 +طيب نيجي لدلالة وجود كيف أستدل على وجود Nucleated + +305 +00:22:15,260 --> 00:22:19,240 +RBCs من الـ Blood Film؟ طبعا الـ Nucleated RBCs + +306 +00:22:19,240 --> 00:22:23,980 +دلت على شيء فإنما تدل على Active Erythropoiesis صح + +307 +00:22:23,980 --> 00:22:29,780 +من يعني أنه البون مارو عمال بيشتغل بشكل كتير سريع + +308 +00:22:29,780 --> 00:22:32,940 +وكبير كبير فبالتالي بيصير يطلع الـ Nucleated RBCs + +309 +00:22:32,940 --> 00:22:35,820 +على الـ Peripheral Blood اللي هي فعليا هذا شكلها + +310 +00:22:36,440 --> 00:22:40,400 +الـ Nucleated RBCs هي عبارة عن خلايا أصغر شوية من + +311 +00:22:40,400 --> 00:22:44,820 +حجم الـ lymphocyte فبالتالي هتظهرلها فلاج في الـ + +312 +00:22:44,820 --> 00:22:48,380 +white pieces histogram قبل الـ lymphocyte يعني + +313 +00:22:48,380 --> 00:22:52,060 +هتلاقي فيه هذه الـ lymphocyte هتلاقي فيه ارتفاع + +314 +00:22:52,060 --> 00:22:56,440 +بسيط قبل الـ lymphocyte بدل على وجود اللي هي الـ + +315 +00:22:56,440 --> 00:23:01,120 +Nucleated RBCs هيك تقريبا بنكون مرينة على الأشياء + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_raw.json b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_raw.json new file mode 100644 index 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histogram بيوضّح عندك ال .. ال .. ال peaks التلاتة في عندي الـ lymphocyte هذه أول peak لأن أصغر حجم خلايا هي الـ lymphocyte بعد هيك بتيجي عندي الـ monocyte والبازوفيل والإزينوفيل بعد هيك لـ neutrophil", "tokens": [3224, 8315, 2423, 39184, 2418, 3755, 49816, 8032, 1211, 10721, 8978, 2423, 39184, 2418, 3755, 49816, 4724, 1829, 2407, 11242, 11703, 5016, 43242, 4117, 2423, 4386, 2423, 4386, 2423, 26897, 16712, 1211, 9307, 3660, 8978, 18871, 16254, 2423, 39184, 31070, 31078, 975, 29538, 5551, 12610, 10651, 5296, 33456, 5551, 9381, 17082, 2288, 11331, 7435, 2304, 16490, 15040, 25528, 39896, 2423, 39184, 31070, 31078, 975, 39182, 39896, 4117, 4724, 31371, 7435, 1829, 43242, 1829, 2423, 39184, 1108, 31078, 975, 16070, 3555, 31377, 38688, 26895, 16070, 28814, 11622, 9957, 38688, 26895, 39182, 39896, 4117, 5296, 39184, 7989, 11741, 388], "avg_logprob": -0.28874362214487426, "compression_ratio": 1.8067632850241546, "no_speech_prob": 3.5762786865234375e-07, "words": [{"start": 360.26, "end": 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0.85858154296875}, {"start": 376.6, "end": 376.88, "word": " عندي", "probability": 0.658203125}, {"start": 376.88, "end": 377.04, "word": " الـ", "probability": 0.792236328125}, {"start": 377.04, "end": 377.56, "word": " monocyte", "probability": 0.9597981770833334}, {"start": 377.56, "end": 378.28, "word": " والبازوفيل", "probability": 0.552392578125}, {"start": 378.28, "end": 379.2, "word": " والإزينوفيل", "probability": 0.843994140625}, {"start": 379.2, "end": 380.08, "word": " بعد", "probability": 0.83447265625}, {"start": 380.08, "end": 380.48, "word": " هيك", "probability": 0.960693359375}, {"start": 380.48, "end": 380.68, "word": " لـ", "probability": 0.6446533203125}, {"start": 380.68, "end": 381.2, "word": " neutrophil", "probability": 0.9308268229166666}], "temperature": 1.0}, {"id": 17, "seek": 40656, "start": 382.1, "end": 406.56, "text": "الآن السؤال اللي بترح نفسه أنه يعني إحنا بنعرف إنه الـ Monocyte أكبر من الـ Neutrophil مثلا طيب ليش الـ Neutrophil اعتبرها الجهاز أكبر؟ إذا كنتوا فاكرين الـ Principle تاعة قراءة القراءة تاعة الـ White PCs قلنا إنه الجهاز بياخد الخلايا بيعمل لها بيعمل للـ RBC slicing في الشمبر تاع الـ White PCs", "tokens": [6027, 148, 48506, 21136, 33604, 6027, 13672, 1829, 39894, 2288, 5016, 8717, 36178, 3224, 14739, 3224, 37495, 22653, 11933, 5016, 8315, 44945, 3615, 28480, 36145, 3224, 2423, 39184, 4713, 31078, 975, 5551, 4117, 26890, 9154, 2423, 39184, 1734, 325, 11741, 388, 50113, 15040, 23032, 1829, 3555, 32239, 8592, 2423, 39184, 1734, 325, 11741, 388, 1975, 34268, 26890, 11296, 25724, 3224, 31377, 5551, 4117, 26890, 22807, 11933, 15730, 9122, 29399, 14407, 6156, 995, 37983, 9957, 2423, 39184, 38372, 781, 6055, 995, 27884, 12174, 23557, 38207, 3660, 25062, 23557, 38207, 3660, 6055, 995, 27884, 2423, 39184, 5552, 46913, 12174, 1211, 8315, 36145, 3224, 25724, 3224, 31377, 4724, 1829, 47283, 3215, 33962, 15040, 25528, 4724, 1829, 25957, 1211, 5296, 11296, 4724, 1829, 25957, 1211, 24976, 39184, 497, 7869, 46586, 8978, 25124, 2304, 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إزاحة لليسار يعني الخلايا الـ Microcytic طيب، هذا برضه راح يأثر عندي على الـ Platelet Histogram لأنه هيكون في عندي RBCs صغيرة", "tokens": [38688, 1829, 16712, 7649, 1829, 23317, 37037, 15730, 13672, 1829, 6225, 42213, 11933, 11622, 39319, 3660, 24976, 39184, 9038, 12820, 30731, 10874, 3224, 3660, 45595, 3794, 9640, 11933, 11622, 39319, 3660, 24976, 1829, 3794, 9640, 37495, 22653, 33962, 15040, 25528, 2423, 39184, 25642, 1344, 40907, 23032, 1829, 3555, 12399, 23758, 4724, 43042, 3224, 12602, 39319, 7251, 10721, 49115, 18871, 16254, 15844, 2423, 39184, 17461, 15966, 9038, 12820, 5296, 33456, 3224, 39896, 30544, 8978, 18871, 16254, 497, 7869, 82, 20328, 17082, 48923], "avg_logprob": -0.1964557988614571, "compression_ratio": 1.5125628140703518, "no_speech_prob": 6.377696990966797e-06, "words": [{"start": 511.92, "end": 512.32, "word": "وفي", "probability": 0.669677734375}, {"start": 512.32, "end": 512.72, "word": " التاني", "probability": 0.87255859375}, {"start": 512.72, "end": 513.42, 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0.90185546875}, {"start": 542.25, "end": 542.57, "word": " أجينا", "probability": 0.7779541015625}, {"start": 542.57, "end": 543.15, "word": " نطلع", "probability": 0.84832763671875}, {"start": 543.15, "end": 543.29, "word": " على", "probability": 0.72607421875}, {"start": 543.29, "end": 543.45, "word": " الـ", "probability": 0.7392578125}, {"start": 543.45, "end": 543.75, "word": " Platelet", "probability": 0.9189453125}, {"start": 543.75, "end": 544.51, "word": " Histogram", "probability": 0.97607421875}, {"start": 544.51, "end": 545.45, "word": " المفروض", "probability": 0.940673828125}, {"start": 545.45, "end": 545.93, "word": " ينزل", "probability": 0.9920654296875}, {"start": 545.93, "end": 546.13, "word": " لـ", "probability": 0.68310546875}, {"start": 546.13, "end": 546.41, "word": " Platelet", "probability": 0.930908203125}, {"start": 546.41, "end": 547.07, "word": " Histogram", "probability": 0.975830078125}, {"start": 547.07, "end": 547.93, "word": " لكن", "probability": 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{"start": 1070.24, "end": 1070.58, "word": " كمان", "probability": 0.76904296875}, {"start": 1070.58, "end": 1070.9, "word": " يعني", "probability": 0.81884765625}, {"start": 1070.9, "end": 1071.46, "word": " هيظهر", "probability": 0.9239501953125}, {"start": 1071.46, "end": 1071.64, "word": " في", "probability": 0.8798828125}, {"start": 1071.64, "end": 1072.04, "word": " عندي", "probability": 0.6146240234375}, {"start": 1072.04, "end": 1072.54, "word": " Flag", "probability": 0.80322265625}, {"start": 1072.54, "end": 1072.92, "word": " قبل", "probability": 0.985595703125}, {"start": 1072.92, "end": 1073.08, "word": " الـ", "probability": 0.893310546875}, {"start": 1073.08, "end": 1073.7, "word": " Lymphocyte", "probability": 0.808837890625}, {"start": 1073.7, "end": 1073.86, "word": " في", "probability": 0.91845703125}, {"start": 1073.86, "end": 1074.1, "word": " هذه", "probability": 0.94873046875}, {"start": 1074.1, "end": 1074.72, "word": " المنطقة", "probability": 0.9927978515625}, 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{"start": 1079.24, "end": 1079.74, "word": " وجود", "probability": 0.988525390625}, {"start": 1079.74, "end": 1080.26, "word": " Platelet", "probability": 0.88623046875}, {"start": 1080.26, "end": 1080.86, "word": " Aggregate", "probability": 0.97021484375}, {"start": 1080.86, "end": 1081.04, "word": " هاي", "probability": 0.53271484375}, {"start": 1081.04, "end": 1081.44, "word": " واضح", "probability": 0.9853515625}, {"start": 1081.44, "end": 1081.62, "word": " في", "probability": 0.98095703125}, {"start": 1081.62, "end": 1081.84, "word": " Case", "probability": 0.83056640625}, {"start": 1081.84, "end": 1082.14, "word": " 1", "probability": 0.6904296875}, {"start": 1082.14, "end": 1082.7, "word": " وفي", "probability": 0.6754150390625}, {"start": 1082.7, "end": 1082.92, "word": " Case", "probability": 0.9892578125}, {"start": 1082.92, "end": 1083.08, "word": " 2", "probability": 0.986328125}, {"start": 1083.08, "end": 1083.56, "word": " إنه", "probability": 0.7724609375}, {"start": 1083.56, "end": 1084.12, "word": " الـ", "probability": 0.949951171875}, {"start": 1084.12, "end": 1084.5, "word": " Curve", "probability": 0.91845703125}, {"start": 1084.5, "end": 1084.88, "word": " ضلوا", "probability": 0.6175944010416666}, {"start": 1084.88, "end": 1085.02, "word": " في", "probability": 0.9521484375}, {"start": 1085.02, "end": 1085.62, "word": " البلاتلت", "probability": 0.76748046875}, {"start": 1085.62, "end": 1086.32, "word": " مرتفع", "probability": 0.9881591796875}, {"start": 1086.32, "end": 1086.68, "word": " Curve", "probability": 0.721435546875}, {"start": 1086.68, "end": 1087.16, "word": " البلاتلت", "probability": 0.96376953125}, {"start": 1087.16, "end": 1087.48, "word": " ضلوا", "probability": 0.8292643229166666}, {"start": 1087.48, "end": 1088.0, "word": " مرتفع", "probability": 0.958984375}, {"start": 1088.0, "end": 1088.32, "word": " هنا", "probability": 0.99755859375}, {"start": 1088.32, "end": 1088.9, "word": " زي", "probability": 0.81201171875}, {"start": 1088.9, "end": 1088.96, "word": " ما", "probability": 0.98779296875}, {"start": 1088.96, "end": 1089.16, "word": " انتوا", "probability": 0.7268880208333334}, {"start": 1089.16, "end": 1089.5, "word": " شايفين", "probability": 0.9774169921875}, {"start": 1089.5, "end": 1090.26, "word": " ماانتهاش", "probability": 0.88525390625}], "temperature": 1.0}, {"id": 46, "seek": 110151, "start": 1090.59, "end": 1101.51, "text": "بيقول نفس الأشي ظهرت عندي Flag في curve الـ RBCs أو الـ Histogram تاع الـ … عفوا، عفوا، ظهر هنا Flag في الـ Histogram تاع الـ White Pisces", "tokens": [3555, 1829, 39648, 8717, 36178, 16247, 8592, 1829, 1357, 116, 3224, 43500, 18871, 16254, 37461, 8978, 7605, 2423, 39184, 497, 7869, 82, 34051, 2423, 39184, 9038, 12820, 6055, 45761, 2423, 39184, 5799, 6225, 5172, 14407, 12399, 6225, 5172, 14407, 12399, 1357, 116, 3224, 2288, 34105, 37461, 8978, 2423, 39184, 9038, 12820, 6055, 45761, 2423, 39184, 5552, 43263, 887], "avg_logprob": -0.34163134785021765, "compression_ratio": 1.4265734265734267, "no_speech_prob": 0.0, "words": [{"start": 1090.59, "end": 1091.09, "word": "بيقول", "probability": 0.6752115885416666}, {"start": 1091.09, "end": 1091.41, "word": " نفس", "probability": 0.97021484375}, {"start": 1091.41, "end": 1091.79, "word": " الأشي", "probability": 0.8391927083333334}, {"start": 1091.79, "end": 1092.25, "word": " ظهرت", "probability": 0.78717041015625}, {"start": 1092.25, "end": 1092.53, "word": " عندي", "probability": 0.81298828125}, {"start": 1092.53, "end": 1093.07, "word": " Flag", "probability": 0.74609375}, {"start": 1093.07, "end": 1093.27, "word": " في", "probability": 0.7900390625}, {"start": 1093.27, "end": 1093.71, "word": " curve", "probability": 0.65087890625}, {"start": 1093.71, "end": 1094.05, "word": " الـ", "probability": 0.736328125}, {"start": 1094.05, "end": 1094.75, "word": " RBCs", "probability": 0.53955078125}, {"start": 1094.75, "end": 1094.87, "word": " أو", "probability": 0.88720703125}, {"start": 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a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_raw.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..90d2d16fa7d3104db4fda261c858b670ad13fc14 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/YbYir5pLS7I_raw.srt @@ -0,0 +1,1260 @@ +1 +00:00:00,660 --> 00:00:05,040 +بسم الله الرحمن الرحيم إن شاء الله رب العالمين في + +2 +00:00:05,040 --> 00:00:09,560 +هذا الفيديو راح نراجع مع بعض موضوع الـ Complete + +3 +00:00:09,560 --> 00:00:14,280 +Blood Count طبعا مش هناخد احنا فحص فحص و نقرأهم و + +4 +00:00:14,280 --> 00:00:17,160 +نعرف كيف .. إيش الـ Normal و إيش الـ Abnormal و + +5 +00:00:17,160 --> 00:00:20,560 +كيف بنشغله، لأ يعني أنا اليوم بدي أجيبلكم نتائج + +6 +00:00:20,560 --> 00:00:24,920 +CBC و أركز كتير على جزئية الـ Histogram و الـ + +7 +00:00:24,920 --> 00:00:27,800 +Abnormalities اللي في الـ Histogram هذي إيش ده .. + +8 +00:00:27,800 --> 00:00:31,070 +إيش ده لإلها، إيش مدلولاتها في الـ Diagnosisيعني + +9 +00:00:31,070 --> 00:00:35,390 +كل حاجة قبل ما راح ناخدها وناخد إمتى ممكن تصيرها + +10 +00:00:35,390 --> 00:00:39,550 +لأنه يا بناتي الـCBC جزء لا يتجزأ من الـdiagnosis + +11 +00:00:39,550 --> 00:00:43,350 +للأنيميا من الأشياء المهمة جدا عشان أعرف أعمل + +12 +00:00:43,350 --> 00:00:48,730 +diagnosis جيد للأنيميا أني أعرف أقرأ إيه نيجي + +13 +00:00:48,730 --> 00:00:52,430 +لجزئية الـhistogram ونحاول نفهم أو نراجع مع بعض + +14 +00:00:52,430 --> 00:00:55,900 +إيش هو الـhistogramطبعا بالإضافة للـ Parameters + +15 +00:00:55,900 --> 00:00:59,000 +اللي بتلاقيها مكتوبة في الـ CPC اللي هو عدل الـ + +16 +00:00:59,000 --> 00:01:01,740 +White PCs و الـ RBCs و الـ Platelets و الـ Blood + +17 +00:01:01,740 --> 00:01:05,800 +Indices هتلاقي عندك الـ Histograms هتلاقي عندك + +18 +00:01:05,800 --> 00:01:09,840 +تلاتة Histogram واحد خاص في الـ Platelets واحد خاص + +19 +00:01:09,840 --> 00:01:14,870 +بالـ RBCs واحد خاص بالـ White PCsالـ Figure هذا + +20 +00:01:14,870 --> 00:01:19,550 +اللي عندنا يعني حاول إنه يحط التلاتة histogram مع + +21 +00:01:19,550 --> 00:01:25,530 +بعض عشان يورجيكي كمقارنة يعني عامل ما بين الأحجام + +22 +00:01:25,530 --> 00:01:28,690 +بتاعة الخلايا حسب ما بيعدها الجهاز طبعا إحنا + +23 +00:01:28,690 --> 00:01:33,030 +عارفين إنه الجهاز بيعد الخلايا على حسب أحجامها + +24 +00:01:33,030 --> 00:01:37,570 +يعني مثلا بيعرف هذه Platelet في حجم معين بيعده إنه + +25 +00:01:37,570 --> 00:01:41,270 +Platelet إذا كانت من 2 إلى 20 مثلا بيعدها Platelet + +26 +00:01:41,700 --> 00:01:46,520 +من 36 إلى 360 بعيدها الـ Erythrocyte فيم توليتر + +27 +00:01:46,520 --> 00:01:51,220 +اللي هو الـ Diameter بتاع الخلية و هكذا طبعاً + +28 +00:01:51,220 --> 00:01:55,180 +الرسمها دي إيش مدلولها أو على إيش بتدل هنا عندي + +29 +00:01:55,180 --> 00:02:01,630 +حجم الخلية فده حجم الخلية تمام هناالـ Frequency + +30 +00:02:01,630 --> 00:02:05,690 +تاعها يعني مثلًا بالنسبة للـ Platelet هذا الـ + +31 +00:02:05,690 --> 00:02:08,510 +Curve تاع الـ Platelet على سبيل المثال طلع معايا + +32 +00:02:08,510 --> 00:02:11,470 +هكذا هذا يوضح الـ Frequency للـ Platelet يعني + +33 +00:02:11,470 --> 00:02:16,290 +مثلًا عد عندي خلايا أربعة فمتو لتر الخلية حجمها + +34 +00:02:16,290 --> 00:02:20,570 +أربعة فمتو لتر هنا أداش في عندي خلايا أربعة فمتو + +35 +00:02:20,570 --> 00:02:24,470 +لتر خمسة فمتو لتر و هكذا يعني هنا بيبينلي حجم + +36 +00:02:24,470 --> 00:02:28,410 +الخلية وهنا بيبينلي ال frequency تاع الخلية هذه + +37 +00:02:29,340 --> 00:02:33,980 +طبعاً برضه إذا كنا فاكرين إن الـ Platelets و الـ + +38 +00:02:33,980 --> 00:02:38,000 +Erythrocyte بنعدوا على نفس الشمبر في نفس الشمبر، + +39 +00:02:38,000 --> 00:02:41,820 +يعني في نفس المكان بس بيميز بينهم الجهاز على حسب + +40 +00:02:41,820 --> 00:02:48,920 +حجم الخلايا بينما الـ YPCs بتدخل في مسار تاني + +41 +00:02:48,920 --> 00:02:52,480 +بتقرأ هي و الـ Hemoglobin بحيث بيصير License للـ + +42 +00:02:52,480 --> 00:02:56,940 +RPCsوبتظل عندى بس الـ white pieces بتم عد الـ + +43 +00:02:56,940 --> 00:03:00,140 +white pieces برضه بنفس الطريقة على حسب أحجامها + +44 +00:03:00,140 --> 00:03:06,220 +تصنف إلى lymphocyte وإلى mid وgranulocyte وبعد هيك + +45 +00:03:06,220 --> 00:03:11,160 +في نفس الشمبر بتم قراءة الهيموجلوبين باستخدام كتبة + +46 +00:03:11,160 --> 00:03:14,620 +الـ photometry يعني بتمرير ضوء معين وقياس ال + +47 +00:03:14,620 --> 00:03:19,310 +absorbance وبحسب للجهاز الهيموجلوبينإذاً هذه + +48 +00:03:19,310 --> 00:03:23,790 +الرسمة هو دامش فيها التلاتة Histogram مع بعض إحنا + +49 +00:03:23,790 --> 00:03:27,570 +في الـCBC بنشوف كل واحدة لحال البلاترف لحال + +50 +00:03:27,570 --> 00:03:33,030 +والـRBCs لحال والـWhite PCs لحال المرحلة اللي بعد + +51 +00:03:33,030 --> 00:03:36,330 +هيك حنا خد واحد واحد ونشوف الـAbnormalities اللي + +52 +00:03:36,330 --> 00:03:39,610 +ممكن تسير في الـCurve وانا كيف لما أشوفها في + +53 +00:03:39,610 --> 00:03:43,210 +الـHistogram كيف أنا ممكن أستدل من خلالها على وجود + +54 +00:03:43,210 --> 00:03:49,380 +خلل معين أو حالة مرضية معينةهذا رسم يعني لأ مش + +55 +00:03:49,380 --> 00:03:53,180 +بالشرط يكون رسم صحيح يعني الـ Platelets في + +56 +00:03:53,180 --> 00:03:56,180 +Instagram ما بيكون شكله هيك والـ Granulocyte برضه + +57 +00:03:56,180 --> 00:04:00,280 +هنا ما بتكون هيك يعني بس هو كرسم تخطيطي عشان هذا + +58 +00:04:00,280 --> 00:04:04,060 +الهدف منه أنه يبينلك المقارنة بين أحجام الخلايا + +59 +00:04:04,060 --> 00:04:08,060 +يعني أصغر حاجة لـPlatelets هلأ الـRBCs بعد هيك + +60 +00:04:08,060 --> 00:04:11,180 +الـLymphocyte بتيجي تقريبا قريبة من الـRBCs + +61 +00:04:11,180 --> 00:04:16,390 +والـMed Cellsوالـ mid-cells بعد هيك للـ + +62 +00:04:16,390 --> 00:04:20,970 +granulocyte طيب + +63 +00:04:20,970 --> 00:04:24,970 +نيجي هنا للهيستوجرام بتاع الـ platelets وتاع + +64 +00:04:24,970 --> 00:04:30,710 +الاريثرocyte عند البلاتلت بتنعد تقريبا من 2 إلى 20 + +65 +00:04:30,710 --> 00:04:34,840 +أو إلى 25 بعيدها الجهاز على إنها plateletsأيه بعد + +66 +00:04:34,840 --> 00:04:37,900 +هيك بيصير انخفاض في ال care في ال histogram وبيبلش + +67 +00:04:37,900 --> 00:04:41,180 +يطلع اللي هو بتاع ال RBCs احنا ماهنشوفهم هيك في ال + +68 +00:04:41,180 --> 00:04:45,080 +histogram في ال CBC احنا هنشوف كل واحد لحال لكن هم + +69 +00:04:45,080 --> 00:04:48,000 +فعليا يعني بتيجي ال blessed و بتخلص بعد هيك + +70 +00:04:48,000 --> 00:04:51,700 +التدائل erythrocyteهلاقيت لو أجينا للـ Histogram + +71 +00:04:51,700 --> 00:04:56,440 +مثلا لـ Platelet الـ Platelet متوسط حجمها من 8 إلى + +72 +00:04:56,440 --> 00:05:00,880 +12 فهتلاقي أكتر ارتفاع من 8 إلى 12 لماذا؟ لأن معظم + +73 +00:05:00,880 --> 00:05:04,320 +الخلايا هتقع في الـ Normal Range صح؟ لشان هيك هو + +74 +00:05:04,320 --> 00:05:07,520 +أخد هذا المنظر أكتر accumulation أو أكتر + +75 +00:05:07,520 --> 00:05:11,630 +percentage للخلايا هتلاقيها في هذه المنطقةنفس + +76 +00:05:11,630 --> 00:05:15,410 +الأشي بالنسبة للـ RBCs هتلاقي الارتفاع في منطقة + +77 +00:05:15,410 --> 00:05:19,190 +الـ MCV الـ Normal من 8 إلى 100، من 80 إلى 100 هذا + +78 +00:05:19,190 --> 00:05:24,240 +إذا كانت العينة طبعا Normalهتلاقي فيه تقريبًا + +79 +00:05:24,240 --> 00:05:28,680 +تطابق مع الـ MCV مع الـ Peak يعني وين الـ Peak + +80 +00:05:28,680 --> 00:05:33,200 +بتاعة الـ Histogram هتلاقيها تقريبًا نفسها هي الـ + +81 +00:05:33,200 --> 00:05:36,820 +MCV ليش؟ لأن الـ MCV هي الـ Main Volume بتاع + +82 +00:05:36,820 --> 00:05:41,080 +الخلايا المتوسط، متوسط حجم الخلايا وأكيد القيمة + +83 +00:05:41,080 --> 00:05:45,140 +المتوسطة ده الـ Average عادةً هو يمثل أكثر القيم + +84 +00:05:45,140 --> 00:05:48,380 +اضطرارًا في الـ Curve، تمام؟ + +85 +00:06:00,260 --> 00:06:04,700 +هنا الـ white pieces histogram هلأ في الـ white + +86 +00:06:04,700 --> 00:06:09,380 +pieces histogram بيوضّح عندك ال .. ال .. ال peaks + +87 +00:06:09,380 --> 00:06:13,360 +التلاتة في عندي الـ lymphocyte هذه أول peak لأن + +88 +00:06:13,360 --> 00:06:16,600 +أصغر حجم خلايا هي الـ lymphocyte بعد هيك بتيجي + +89 +00:06:16,600 --> 00:06:20,480 +عندي الـ monocyte والبازوفيل والإزينوفيل بعد هيك + +90 +00:06:20,480 --> 00:06:26,480 +لـ neutrophilالآن السؤال اللي بترح نفسه أنه يعني + +91 +00:06:26,480 --> 00:06:29,360 +إحنا بنعرف إنه الـ Monocyte أكبر من الـ Neutrophil + +92 +00:06:29,360 --> 00:06:33,740 +مثلا طيب ليش الـ Neutrophil اعتبرها الجهاز أكبر؟ + +93 +00:06:33,740 --> 00:06:36,520 +إذا كنتوا فاكرين الـ Principle تاعة قراءة القراءة + +94 +00:06:36,520 --> 00:06:41,900 +تاعة الـ White PCs قلنا إنه الجهاز بياخد الخلايا + +95 +00:06:41,900 --> 00:06:46,060 +بيعمل لها بيعمل للـ RBC slicing في الشمبر تاع الـ + +96 +00:06:46,060 --> 00:06:50,000 +White PCsونفس المحلول الـ Lysing Reagent اللي أنا + +97 +00:06:50,000 --> 00:06:54,200 +بحطه بعمل Shrinking للـ White BCs يعني بعمل + +98 +00:06:54,200 --> 00:06:59,500 +Collapse للخلية حوالين النواء فبالتالي بيصير حجم + +99 +00:06:59,500 --> 00:07:05,560 +الـ Cytoplasm لا قيمة له وبتم العد الحقيقي حسب حجم + +100 +00:07:05,560 --> 00:07:10,320 +النواء عشان هيك لـ Neutrophil إن عدت علي إنها أكبر + +101 +00:07:10,320 --> 00:07:15,090 +واحدةوهدول كلهم بيعدهم ضمن الـ mid-region اللي هي + +102 +00:07:15,090 --> 00:07:21,330 +الـ monocyte والبازوفيل والإزينوفيل خلّيني أنا أخد + +103 +00:07:21,330 --> 00:07:25,170 +بعض الأمثلة اللي يعني نحط فيها بعض صور الـ + +104 +00:07:25,170 --> 00:07:31,190 +histogram ونحاول نشوف إيش دلالتها عندي هنا two + +105 +00:07:31,190 --> 00:07:38,970 +CBCs والتانية اللي لهم علاقة بالأنميا لكن يعني في + +106 +00:07:38,970 --> 00:07:44,360 +فرق في ال diagnosisبس اشتراك في الـ category بتاعة + +107 +00:07:44,360 --> 00:07:48,600 +الانيمي خلينا نفهم إيش الكلام اللي بقوله الآن لو + +108 +00:07:48,600 --> 00:07:56,020 +إجينا نبطلع على ال histogram أول حاجة راح نلاحظها + +109 +00:07:56,020 --> 00:08:03,750 +إن ال RBCs histogram صيرله شوية shift to leftيعني + +110 +00:08:03,750 --> 00:08:08,890 +الـ Peak مفروض تكون ما بين 80 إلى 100 لكن هنا الـ + +111 +00:08:08,890 --> 00:08:14,190 +Peak لأ تقريبا عند بين الـ 60 والـ 70 طيب على إيش + +112 +00:08:14,190 --> 00:08:19,870 +بدل هذا؟ على إنه حجم الخلايا صغير والتاني نفس + +113 +00:08:19,870 --> 00:08:24,590 +الاشي الـ Histogram إنه صاير Shift to Lift لو + +114 +00:08:24,590 --> 00:08:29,110 +أجينا نتطلع على الـ MCV فعلا هنلاقي إن الـ MCV + +115 +00:08:29,110 --> 00:08:35,260 +منخفضة في التنين هنا 65وفي التاني 68 وهذا اللي عمل + +116 +00:08:35,260 --> 00:08:39,920 +إزاحة للـ Histogram إلى جهة اليسار إزاحة لليسار + +117 +00:08:39,920 --> 00:08:45,040 +يعني الخلايا الـ Microcytic طيب، هذا برضه راح يأثر + +118 +00:08:45,040 --> 00:08:49,080 +عندي على الـ Platelet Histogram لأنه هيكون في عندي + +119 +00:08:49,080 --> 00:08:53,830 +RBCs صغيرةهتظهر في الـ Area ما بين الـ Platelet + +120 +00:08:53,830 --> 00:08:57,450 +Histogram و الـ Erythrocyte Histogram وهذا اللي + +121 +00:08:57,450 --> 00:09:01,170 +ظاهر فعليًا في الـ Platelet Histogram زي ما انتوا + +122 +00:09:01,170 --> 00:09:04,510 +شايفين لو أجينا نطلع على الـ Platelet Histogram + +123 +00:09:04,510 --> 00:09:09,370 +المفروض ينزل لـ Platelet Histogram لكن في عند هنا + +124 +00:09:09,370 --> 00:09:13,570 +شوية ارتفاع ما بين الـ Platelet Histogram و الـ + +125 +00:09:13,570 --> 00:09:17,950 +Erythrocyte Histogramطبعاً إذا دل على شيء هذا يدل + +126 +00:09:17,950 --> 00:09:23,630 +على إنه في عندي أشياء حجمها متوسط ما بين الـ + +127 +00:09:23,630 --> 00:09:28,650 +Platelets و الـ Erthrocytes عيننا هنا يتضح إنه هي + +128 +00:09:28,650 --> 00:09:33,070 +عبارة عن Microcytic Erthrocytes لأن الـ MCV قليل + +129 +00:09:33,070 --> 00:09:37,930 +طيب هنا لو أجينا نشوف ال diagnosis هنلاقي ال + +130 +00:09:37,930 --> 00:09:42,430 +diagnosis هنا Iron Deficiency Anemia بينما هنا ال + +131 +00:09:42,430 --> 00:09:47,870 +diagnosis Suspectedثلاثيمية طيب خلّينا نشوف لو + +132 +00:09:47,870 --> 00:09:53,210 +أجينا للـRBCs للـCBC عفواً في الـIron Deficiency + +133 +00:09:53,210 --> 00:09:57,350 +أنيمية هنلاقي الـRBCs منخفضة والثلاثيمية هنلاقيها + +134 +00:09:57,350 --> 00:10:03,210 +مرتفعة شغلة تانية لو أجينا يعني الـMCV أحياناً + +135 +00:10:03,210 --> 00:10:06,030 +كتير في الثلاثيمية بيكون تحت السبعين بينما + +136 +00:10:06,030 --> 00:10:09,630 +بالـIron Deficiency بيكون فوق السبعينوإن كان هنا + +137 +00:10:09,630 --> 00:10:13,350 +التنين في تشابه بينهم التنين تحت السبعين فبالتالي + +138 +00:10:13,350 --> 00:10:21,450 +هذا ما فصل عندي بين التنتين اللي هو الـ MCV نيجي + +139 +00:10:21,450 --> 00:10:27,290 +لحاجة مهمة كتير اللي هي الـ RDW الـ RDW عادة تدل + +140 +00:10:27,290 --> 00:10:31,460 +على درجة الـ variation في أحجام الخلاياوهذه الـ + +141 +00:10:31,460 --> 00:10:35,480 +RDW يعني من الأشياء المهمة جدًا اللي بنفرق من + +142 +00:10:35,480 --> 00:10:38,900 +خلالها ما بين الثلاثيميا والـ Iron Deficiency + +143 +00:10:38,900 --> 00:10:42,240 +Anemia هنا في الـ Iron Deficiency Anemia هنلاقيه + +144 +00:10:42,240 --> 00:10:44,940 +مرتفع لأنه في الـ Iron Deficiency الخلايا بيكون + +145 +00:10:44,940 --> 00:10:48,480 +فيه variation في أحجامها بينما في الثلاثيميا + +146 +00:10:48,480 --> 00:10:54,020 +هنلاقيه تقريبًا Normal اللي هو 14.7% مما يدل على + +147 +00:10:54,020 --> 00:10:58,520 +أنه فيه تقارب صحي الخلايا الصغيرة لكن فيه تقارب في + +148 +00:10:58,520 --> 00:11:02,780 +أحجام الخلاياإذا الحالتين لنفس الكاتيجوريا + +149 +00:11:02,780 --> 00:11:06,940 +Microcytic Hypochromic Anemia Microcytosis and + +150 +00:11:06,940 --> 00:11:12,340 +Hypochromia وهذه التنتين كان في .. إيش ال + +151 +00:11:12,340 --> 00:11:15,700 +diagnosis؟ هو بقولك هنا دي Suspected Thalassemia + +152 +00:11:15,700 --> 00:11:19,500 +طبعاً بنعمل confirmation ب Hemoglobin A2 and + +153 +00:11:19,500 --> 00:11:21,220 +Hemoglobin Electrophoresis + +154 +00:11:23,120 --> 00:11:27,760 +بنجي لصورة تانية بتجمع ما بين الـ Histogram بتاع + +155 +00:11:27,760 --> 00:11:32,320 +الـ RBCs و بتاع الـ YPCs خلّينا أول حاجة ناخد هذا + +156 +00:11:32,320 --> 00:11:36,360 +الـ Histogram هنا عند الـ Histogram لو أجينا نطلع + +157 +00:11:36,360 --> 00:11:41,040 +هنلاقيه Bimodal بقولك هذه الحالة عبارة عن Iron + +158 +00:11:41,040 --> 00:11:45,550 +deficiency anemia under treatmentيعني بداية كانت + +159 +00:11:45,550 --> 00:11:50,030 +الخلايا Microcytic لكن لما بلش المريض بلشت تظهر + +160 +00:11:50,030 --> 00:11:54,190 +عندى كاتيجورى تانية من الخلايا اللى هى Normocytic + +161 +00:11:54,190 --> 00:12:01,770 +فصار عندى الـ Histogram بايمودلبعد أربع أسابيع من + +162 +00:12:01,770 --> 00:12:06,810 +العلاج لو نزلنا لتحت بالصورة هنلاحظ إنه بلشت + +163 +00:12:06,810 --> 00:12:10,570 +الخلايا اللي حجمها طبيعي ترتفع وتصير أكتر من + +164 +00:12:10,570 --> 00:12:14,950 +الخلايا الـ Microcytic هذا بيدل على إنه في استجابة + +165 +00:12:14,950 --> 00:12:18,810 +في العلاج طبعا لو أجينا إحنا نتطلع على الـ + +166 +00:12:18,810 --> 00:12:22,910 +Histogram هنلاقي الـ Histogram هنا صار عندي واسع + +167 +00:12:22,910 --> 00:12:29,070 +أو عريض كتير هذا أكيد الـ RDW لإله هتكون عاليةالـ + +168 +00:12:29,070 --> 00:12:34,150 +RDW بالمفهوم البسيط هي الـ Variation بين أحجام + +169 +00:12:34,150 --> 00:12:39,850 +الخلايا وممكن لو طلعنا على الـ Histogram ناخد فكرة + +170 +00:12:39,850 --> 00:12:45,790 +عن وضع الـ RDW لأنها ببساطة Red Distribution Curve + +171 +00:12:45,790 --> 00:12:49,420 +Widthيعني هذا الـ Curve بتاع الـ Erythrocyte قداش + +172 +00:12:49,420 --> 00:12:52,840 +الـ Width بتاعه، قداش العرض أو قداش الاتساع بتاع + +173 +00:12:52,840 --> 00:12:56,520 +الـ Curve فكل ما كان الـ Curve أعرض، دال على إنه + +174 +00:12:56,520 --> 00:13:02,580 +فيه تباين أكتر للخلايا وكل ما دال على إنه الـ RDW + +175 +00:13:02,580 --> 00:13:06,380 +مرتفع أكتر، إذن هذه حالة Iron Deficiency Anemia + +176 +00:13:06,380 --> 00:13:10,890 +Under Treatmentطيب، نيجي للحالة التانية اللي على + +177 +00:13:10,890 --> 00:13:13,730 +الجهة التانية من الـ slide اللي هي الـ Macrocytic + +178 +00:13:13,730 --> 00:13:19,210 +Anemia وهي بقولك حالة CML طبعاً خلينا ناخدهم واحدة + +179 +00:13:19,210 --> 00:13:22,790 +واحدة الـ RBCs Histogram لحال والـ White BCs + +180 +00:13:22,790 --> 00:13:25,870 +Histogram لحال أول حاجة هو حاكي عن الـ White BCs + +181 +00:13:25,870 --> 00:13:29,370 +Histogram طبعاً إحنا بنعرف إن الـ White BCs + +182 +00:13:29,370 --> 00:13:32,710 +Histogram في تلاتة فلاج الأولى اللي هي الـ + +183 +00:13:32,710 --> 00:13:37,420 +lymphocyteالتانية الـ Med التالتة لـ Granulocyte + +184 +00:13:37,420 --> 00:13:41,240 +أو اللي هي لـ Neutrophil هنا هنلاحظ ارتفاع في + +185 +00:13:41,240 --> 00:13:44,960 +منطقة الـ Med فهذا بيدل على وجود Immature + +186 +00:13:44,960 --> 00:13:48,880 +Granulocyte بكل أنواعها، ممكن تكون Myelocyte، + +187 +00:13:48,880 --> 00:13:52,480 +Metamyelocyte وانتوا عارفين الـCML بيبقى فيها + +188 +00:13:52,480 --> 00:13:57,420 +Abnormal Cells اللي هي Immature Stages من الـ + +189 +00:13:57,420 --> 00:14:01,440 +Granulocyte فهي ظهرت في الـ Histogram في هذه + +190 +00:14:01,440 --> 00:14:08,260 +المنطقةالشغل التاني اللي بدنا نحكيها اللي هي بخصوص + +191 +00:14:08,260 --> 00:14:14,700 +الـ RBCs Histogramلو لاحظنا هنلاقي إن الـ + +192 +00:14:14,700 --> 00:14:18,280 +Erythrocyte هستجرام سيرله Shift لفت يعقف عن Shift + +193 +00:14:18,280 --> 00:14:23,080 +Right يعني الـ Curve كله اتحرك إلى جهة اليمين هذا + +194 +00:14:23,080 --> 00:14:27,200 +إذا دل على شيء بيدل على إن الخلايا حجمها كبير طيب + +195 +00:14:27,200 --> 00:14:31,320 +نشوف الـ MCV هل الخلايا فعلا حجمها كبير فعلا + +196 +00:14:31,320 --> 00:14:39,680 +الخلايا كبيرة 110 فمتو لتر فبالتالي استنتاجنا كان + +197 +00:14:39,680 --> 00:14:46,650 +صحيحطيب نيجي هنا لحالات يعني متفرقة هنا بقولك حالة + +198 +00:14:46,650 --> 00:14:51,490 +Anesocytosis يعني في عندي Variation بالـ RBCs Size + +199 +00:14:51,490 --> 00:14:55,950 +أكتر حاجة بلاحظها، بنات احنا ممكن هنا ألاحظ أن الـ + +200 +00:14:55,950 --> 00:15:00,010 +MCV تقريبًا تقريبًا يعني With الـ Normal Range على + +201 +00:15:00,010 --> 00:15:03,270 +ال Upper Limit الـ Normal احنا قولنا من 80 لـ 97 + +202 +00:15:03,270 --> 00:15:07,650 +أعلى شوية من الـ Normal يعني الخلايا حجمها أكبر + +203 +00:15:07,650 --> 00:15:12,700 +شوية لكن الأكثر، الحاجة الملحوظة أكثرإنه فيه تباين + +204 +00:15:12,700 --> 00:15:17,240 +كتير كبير في حجم الخلايا دليل هيك إنه شايفين الـ + +205 +00:15:17,240 --> 00:15:22,020 +Histogram أداش واسع من هذه المنطقة طبعاً اتساع الـ + +206 +00:15:22,020 --> 00:15:26,060 +Histogram بيدل على إنه الـ RDW عالي وإنه فيه تباين + +207 +00:15:26,060 --> 00:15:33,080 +كبير بين أحجام الخلايا طب نشوف الـ RDW 22.7% صحيح + +208 +00:15:33,080 --> 00:15:37,080 +الكلام، إذن في عندى Variation في أحجام الخلايا + +209 +00:15:37,080 --> 00:15:42,400 +كبيرةوهذا نفس الفكرة عندنا لو لاحظنا هنلاقي الـ + +210 +00:15:42,400 --> 00:15:49,760 +MCV مرتفعة والـ RDW برضه 26 وهذا طبعاً استدلان + +211 +00:15:49,760 --> 00:15:57,520 +عليه كمان من خلال اتساع الـ Histogram نيجي + +212 +00:15:57,520 --> 00:16:00,680 +لهنا حاجة خاصة بالـ Curve بتاع الـ Platelet أو + +213 +00:16:00,680 --> 00:16:04,200 +بالـ Histogram بتاع الـ Platelet هنا لو لاحظنا + +214 +00:16:04,200 --> 00:16:11,830 +هنلاقي الـ Histogramعريض شوية بالإضافة بالإضافة + +215 +00:16:11,830 --> 00:16:15,710 +مثلا في عندي في ال «Castle» في عندي في هذه المنطقة + +216 +00:16:15,710 --> 00:16:19,670 +ارتفاع في فلاج في هذه المنطقة في عندي هنا حاجة + +217 +00:16:19,670 --> 00:16:24,010 +بيسموها «Percent of Large Cells» أو «Percent of + +218 +00:16:24,010 --> 00:16:26,510 +Large Platelets» هذا بيبين عندي نسبة قداش في عندي + +219 +00:16:26,510 --> 00:16:30,890 +«Giant Platelets» هنا عندي 44% يعني نسبة عالية من + +220 +00:16:30,890 --> 00:16:34,620 +الـ «Giant Platelets»Blatelet Distribution Width + +221 +00:16:34,620 --> 00:16:37,860 +برضه الـ Distribution Width للـ Blatelets زي و زي + +222 +00:16:37,860 --> 00:16:41,200 +الـ Distribution Width للـ RBCs بيبين عندي قداش + +223 +00:16:41,200 --> 00:16:44,600 +فيه تباين بأحجام الـ Blatelets عندي برضه هنا هي + +224 +00:16:44,600 --> 00:16:48,550 +أعطاني Flag إنه مرتفع عالي زي ما أنتوا تفكرونواللي + +225 +00:16:48,550 --> 00:16:52,310 +دلّل عندى هنا على وجود Giant Platelets وجود الـ + +226 +00:16:52,310 --> 00:16:55,770 +Curve هنا فيه يعني مش نازل زي ما احنا متعودين هو + +227 +00:16:55,770 --> 00:16:59,790 +من 6 إلى 8 وبينزل لكن عندى هنا في هذه الحالة Case + +228 +00:16:59,790 --> 00:17:02,330 +2 زي ما انتوا ملاحظين كتير هذه واضحة انه Large + +229 +00:17:02,330 --> 00:17:06,510 +Platelets وبأحجام متباينة والـ Curve عند نهايته + +230 +00:17:06,510 --> 00:17:10,950 +هنا ما نزل يعني ضل الـ Curve مرتفع دليل على وجود + +231 +00:17:10,950 --> 00:17:15,790 +Platelets وشبك مع الـ RBCs Testogram يعني ممكن حتى + +232 +00:17:15,790 --> 00:17:17,450 +هنا يكون فيه Large Platelets + +233 +00:17:20,570 --> 00:17:25,310 +هنا نيجي للـ Platelet Aggregation كيف ممكن تظهر + +234 +00:17:25,310 --> 00:17:29,730 +الـ Platelet Aggregation ممكن تظهر معايا على شكل + +235 +00:17:29,730 --> 00:17:32,910 +إنه الـ Curve برضه ما انتهاش يعني لأنه الـ + +236 +00:17:32,910 --> 00:17:38,150 +Platelet Aggregate هتنعد على إنه كل مجموعة من الـ + +237 +00:17:38,150 --> 00:17:41,950 +Aggregate هتنعد على إنها Large Platelet فهيكون وضع + +238 +00:17:41,950 --> 00:17:44,910 +الـ Histogram شبيه بوضع الـ Giant أو Large + +239 +00:17:44,910 --> 00:17:49,760 +Plateletالـ Platelet Aggregates هتظهر مع الـ White + +240 +00:17:49,760 --> 00:17:53,080 +BCs كمان يعني هيظهر في عندي Flag قبل الـ + +241 +00:17:53,080 --> 00:17:56,120 +Lymphocyte في هذه المنطقة في الـ Histogram بتاع + +242 +00:17:56,120 --> 00:17:59,740 +الـ White BCs إذا ظهر معايا احتمال يكون وجود + +243 +00:17:59,740 --> 00:18:03,080 +Platelet Aggregate هاي واضح في Case 1 وفي Case 2 + +244 +00:18:03,080 --> 00:18:06,680 +إنه الـ Curve ضلوا في البلاتلت مرتفع Curve + +245 +00:18:06,680 --> 00:18:09,500 +البلاتلت ضلوا مرتفع هنا زي ما انتوا شايفين + +246 +00:18:09,500 --> 00:18:13,710 +ماانتهاشبيقول نفس الأشي ظهرت عندي Flag في curve + +247 +00:18:13,710 --> 00:18:17,790 +الـ RBCs أو الـ Histogram تاع الـ … عفوا، عفوا، + +248 +00:18:17,790 --> 00:18:21,510 +ظهر هنا Flag في الـ Histogram تاع الـ White Pisces + +249 +00:18:25,290 --> 00:18:29,010 +وجود Cold Agglutinane Cold Agglutinane يعني + +250 +00:18:29,010 --> 00:18:32,790 +Irregular Agglutination للخلايا يعني هتلاقي في + +251 +00:18:32,790 --> 00:18:36,990 +عندنا Variation في الـ Size في خلايا خلية لحالة في + +252 +00:18:36,990 --> 00:18:40,750 +تنتين في تلاتة يعني كأنه أنا بحكي عن Anesocytosis + +253 +00:18:40,750 --> 00:18:44,850 +بال picture هنابالـ Picture هيكون عندى الـ RDW + +254 +00:18:44,850 --> 00:18:48,450 +عالية ليش؟ لأنه فيه تباين فيه خليتان وفيه تلاتة + +255 +00:18:48,450 --> 00:18:52,510 +اتجمعوا فيه أكتر من هيك فبالتالي كل مجموعة هتنعد + +256 +00:18:52,510 --> 00:18:57,790 +على أنها خلية ذات حجم خاص فهذا هيعطيني إشارة على + +257 +00:18:57,790 --> 00:19:02,530 +أنه فيه تباين بأحجام الخلايا ويبقى الـ RDW مرتفع + +258 +00:19:02,530 --> 00:19:06,790 +زي ما إحنا شايفين هناهي لو لاحظنا هي الـ Curve + +259 +00:19:06,790 --> 00:19:11,150 +والـ Curve برضه لو لاحظنا برضه الـ MCV مرتفعة لأن + +260 +00:19:11,150 --> 00:19:14,810 +الخلايا بدل ما تكون عدد واحدة واحدة هنصير عدة + +261 +00:19:14,810 --> 00:19:18,430 +جمعات كبيرة مما يزيد من الـ MCV إذا الـ Curve + +262 +00:19:18,430 --> 00:19:22,410 +صيرله Shift to Right بعدين في عند فلاج وجود دليل + +263 +00:19:22,410 --> 00:19:25,450 +على وجود يعني أنه ما خلص الـ Curve دليل على أنه في + +264 +00:19:25,450 --> 00:19:28,630 +خلايا كبيرة هنا الخلايا الكبيرة هنا فعليًا هي + +265 +00:19:28,630 --> 00:19:32,980 +عبارة عن Cold Agglutinateهنا بقولك تجربة حلوة إحنا + +266 +00:19:32,980 --> 00:19:36,380 +بعد ما عملنا نفس العينة عملنا لها Incubation + +267 +00:19:36,380 --> 00:19:40,560 +تلاتين دقيقة في سبعة وتلاتين درجة عشان نفكك الـ + +268 +00:19:40,560 --> 00:19:43,300 +Agglutination وعملنا منها فيلم وعملنا منها CBC + +269 +00:19:43,300 --> 00:19:46,480 +طلعت معانا النتيجة اللي على الجهة هذه نشوف إيش طلع + +270 +00:19:46,480 --> 00:19:49,840 +معانا أول حاجة الـ Blood Film صار Normal كان + +271 +00:19:49,840 --> 00:19:53,800 +بالأول فيه Agglutinates لكن هنا صار عندي Normal + +272 +00:19:53,800 --> 00:19:58,100 +الشغلة التانية المهمة لو إجينا للـ Histogram + +273 +00:19:58,100 --> 00:20:03,460 +هنلاقي الـ Histogram صار طبيعيكمان الـ MCV انخفضت + +274 +00:20:03,460 --> 00:20:07,180 +كانت هنا 111 بالأول قبل ما أعمل Incubation كانت + +275 +00:20:07,180 --> 00:20:11,780 +111، هنا صارت 100، ليش؟ لأن الـ Large Aggregates + +276 +00:20:11,780 --> 00:20:16,760 +اتفككت إلى حد ما وعطتني Normal Result أو Normal + +277 +00:20:16,760 --> 00:20:21,120 +Reading، بعدين الـ Flag اللي ظهرت في نهاية عدد تل + +278 +00:20:21,120 --> 00:20:24,580 +تاع الـ Histogram ما ظهرت بعد الـ Incubation، دليل + +279 +00:20:24,580 --> 00:20:27,100 +على أن الأجلوتينيات اتفككت + +280 +00:20:31,160 --> 00:20:34,700 +طيب نيجي هنا لبعض الـ Abnormalities الخاصة بالـ + +281 +00:20:34,700 --> 00:20:38,740 +White PCs لو جينا للـ Histogram هذا هنلاقي يعني + +282 +00:20:38,740 --> 00:20:41,880 +فيه حاجة غلط يعني هنا الأصل احنا عندنا الـ + +283 +00:20:41,880 --> 00:20:45,660 +lymphocyte تبقى مرتفعة والـ neutrophil مابتوصلش لـ + +284 +00:20:45,660 --> 00:20:49,650 +Flag داعتها لهذا الارتفاعها دا بيدل على وجود الـ + +285 +00:20:49,650 --> 00:20:53,090 +Neutrophilia ارتفاع في الـ Neutrophil ولو احنا + +286 +00:20:53,090 --> 00:20:56,230 +اطلعنا على الـ Blood Film هنشوف هذا الكلام الـ + +287 +00:20:56,230 --> 00:21:01,710 +Neutrophil عددها واضح انه كبير اذا الارتفاع لـ + +288 +00:21:01,710 --> 00:21:05,370 +Neutrophil أدى لوجود Flag في هذه المنطقة خلينا + +289 +00:21:05,370 --> 00:21:11,250 +نشوف النسب لـ Neutrophil فعلا 84% طبعا هذا بيصاحبه + +290 +00:21:11,250 --> 00:21:15,210 +زي ما اتفقنا ارتفاع لـ Neutrophil هيصاحبه انخفاض + +291 +00:21:15,210 --> 00:21:18,930 +في الـ lymphocyteنيجي للنتيجة التانية العكس + +292 +00:21:18,930 --> 00:21:23,570 +Lymphocytosis ارتفاع في الـ Lymphocyte ارتفاع في + +293 +00:21:23,570 --> 00:21:29,550 +الـ Lymphocyte حتى يعني لو احنا ملاحظين هنا لـ + +294 +00:21:29,550 --> 00:21:33,050 +Neutrophil كتير قليلة و الـ Peak تبعتها كتير قليلة + +295 +00:21:33,050 --> 00:21:38,750 +نسبة الـ Lymphocyte 64% و لـ Neutrophil 19 أو 19.5 + +296 +00:21:38,750 --> 00:21:40,530 +% تمام؟ + +297 +00:21:45,130 --> 00:21:49,450 +هنا نفس الأشي هنا بقولك Monocytosis طبعا الـ + +298 +00:21:49,450 --> 00:21:53,290 +Monocyte لو ارتفعت هتعمل عند فلاج في منطقة الـ Med + +299 +00:21:53,290 --> 00:21:56,270 +في المنطقة المتوسطة اللي هي بتشمل الـ Monocyte و + +300 +00:21:56,270 --> 00:21:58,870 +الـ Basophil و الـ Azenophil هنا ارتفاع في الـ + +301 +00:21:58,870 --> 00:22:02,130 +Monocyte عمل عند فلاج في هذه المنطقة نفس الأشي لو + +302 +00:22:02,130 --> 00:22:05,530 +صار ارتفاع في الـ Azenophil هيعمل ارتفاع في منطقة + +303 +00:22:05,530 --> 00:22:07,150 +الـ Med cells + +304 +00:22:10,540 --> 00:22:15,260 +طيب نيجي لدلالة وجود كيف أستدل على وجود Nucleated + +305 +00:22:15,260 --> 00:22:19,240 +RBCs من الـ Blood Film؟ طبعا الـ Nucleated RBCs + +306 +00:22:19,240 --> 00:22:23,980 +دلت على شيء فإنما تدل على Active Erythropoiesis صح + +307 +00:22:23,980 --> 00:22:29,780 +من يعني أنه البون مارو عمال بيشتغل بشكل كتير سريع + +308 +00:22:29,780 --> 00:22:32,940 +وكبير كبير فبالتالي بيصير يطلع الـ Nucleated RBCs + +309 +00:22:32,940 --> 00:22:35,820 +على الـ Peripheral Blood اللي هي فعليا هذا شكلها + +310 +00:22:36,440 --> 00:22:40,400 +الـ Nucleated RBCs هي عبارة عن خلايا أصغر شوية من + +311 +00:22:40,400 --> 00:22:44,820 +حجم الـ lymphocyte فبالتالي هتظهرلها فلاج في الـ + +312 +00:22:44,820 --> 00:22:48,380 +white pieces histogram قبل الـ lymphocyte يعني + +313 +00:22:48,380 --> 00:22:52,060 +هتلاقي فيه هذه الـ lymphocyte هتلاقي فيه ارتفاع + +314 +00:22:52,060 --> 00:22:56,440 +بسيط قبل الـ lymphocyte بدل على وجود اللي هي الـ + +315 +00:22:56,440 --> 00:23:01,120 +Nucleated RBCs هيك تقريبا بنكون مرينة على الأشياء + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM.srt new file mode 100644 index 0000000000000000000000000000000000000000..8cd9739c6b412d38421c8fb95d090de977416470 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM.srt @@ -0,0 +1,1867 @@ +1 +00:00:01,690 --> 00:00:06,950 +اللهمّ أعوذ بك من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى في هذا الفصل في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في الـ outlines حكينا إنه هذا المساق بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتم عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبا بتنقسم لـ three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها واللوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +و coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +الثلاثة اللي راح نتناولها في هذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد ذلك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش إني أحفظ إيش تعريف الأنيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش الـ pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط هذه النتائج مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مصاحبة لهذا الـ result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,790 +على فحوصات عشان أتأكد من نتائج معينة هذا الكلام + +20 +00:01:32,790 --> 00:01:36,810 +بإذن الله كله راح نناقشه مع بعض شوية شوية أول حاجة + +21 +00:01:36,810 --> 00:01:37,710 +هنشرحه بعد + +22 +00:01:53,700 --> 00:01:58,300 +الطريقة الأولى أو المعيار الأول لتصنيف الأنيميا + +23 +00:01:58,300 --> 00:02:02,800 +اللي هو الـ morphology للخلايا تم تصنيف الخلايا + +24 +00:02:02,800 --> 00:02:08,680 +حسب الـ MCV إلى ثلاث مجموعات Microcytic، + +25 +00:02:08,680 --> 00:02:13,220 +Normocytic، Macrocytic هذا التصنيف اللي إحنا هنمشي + +26 +00:02:13,220 --> 00:02:18,460 +عليه المعيار الثاني في التصنيف كان الـ + +27 +00:02:18,460 --> 00:02:22,180 +Pathophysiology حسب الميكانيزم أو آلية حدوث المرض + +28 +00:02:22,180 --> 00:02:27,080 +أو سبب المرض طبعا أول حاجة اللي هو Impaired + +29 +00:02:27,080 --> 00:02:30,860 +Erythrocyte Formation أنه في خلل في تصنيع الـ + +30 +00:02:30,860 --> 00:02:38,800 +Erythrocyte قد يكون هذا الخلل بسبب Primary Problem + +31 +00:02:38,800 --> 00:02:42,060 +في الـ bone marrow يعني مشكلة أساسية في الـ bone marrow زي + +32 +00:02:42,060 --> 00:02:45,420 +حالات الـ aplastic anemia يعني خلل في الـ bone marrow ما + +33 +00:02:45,420 --> 00:02:49,790 +بيقدر يصنع خلايا بشكل كافي أو خلل في تصنيع .. في + +34 +00:02:49,790 --> 00:02:53,470 +كمية .. يعني قدرته على تصنيع الـ Hemoglobin لأنه + +35 +00:02:53,470 --> 00:02:57,410 +في مثلا نقص حديد زي Iron Deficiency Anemia زي + +36 +00:02:57,410 --> 00:02:59,450 +Sidroblastic Anemia اللي بيبقى فيها خلل في + +37 +00:02:59,450 --> 00:03:03,410 +البروتوبرفيرين يعني أمثلة أخرى للأنيميا أو الـ + +38 +00:03:03,410 --> 00:03:07,190 +Chronic Disease Megaloplastic Anemia إذا هنا في كل + +39 +00:03:07,190 --> 00:03:11,050 +هذه الحالات تشترك في شغلة إنه في خلل في الـ + +40 +00:03:11,050 --> 00:03:13,890 +Formation للـ RBCs يعني الـ RBCs كميتها هتكون + +41 +00:03:13,890 --> 00:03:17,860 +قليلة في هذه الحالات بشكل عام RBC قليلة + +42 +00:03:17,860 --> 00:03:22,060 +و Reticulocyte قليلة هنا الـ «bone marrow» ما بيقدرش + +43 +00:03:22,060 --> 00:03:25,140 +يستجيب مع المرض يعني حتى لو كان فيه أنيميا الـ bone + +44 +00:03:25,140 --> 00:03:28,220 +marrow ما بيقدر يصنع لأنه فيه نقص في العناصر + +45 +00:03:28,220 --> 00:03:31,760 +الأساسية اللي لازمة للتصنيع فقد ما يكون فيه نقص مش + +46 +00:03:31,760 --> 00:03:35,840 +هيقدر يعوضها مهما اجتهد ومهما اشتغل مش هيقدر لأنه + +47 +00:03:35,840 --> 00:03:38,340 +إلا إذا إحنا أعطينا يعني مثلا فيه نقص حديد بنعطي + +48 +00:03:38,340 --> 00:03:42,300 +حديد بتنشط الـ bone marrow تمام؟ فيه نقص مثلا + +49 +00:03:45,920 --> 00:03:49,700 +الـ group الثانية في هذه الـ category اللي هي + +50 +00:03:49,700 --> 00:03:53,240 +increased blood loss إنه فيه فقد للـ blood قد يكون + +51 +00:03:53,240 --> 00:03:57,100 +بسبب bleeding acute or chronic عادة الـ + +52 +00:03:57,100 --> 00:04:01,260 +reticulocyte هنا بتكون عالية لأنه مافي خلل في + +53 +00:04:01,260 --> 00:04:05,960 +البون مارو وعنده القدرة إنه يعوض أي نزف أو أي فقد + +54 +00:04:05,960 --> 00:04:09,880 +من الـ blood فبنلاقي الـ reticulocyte عالية طبعا + +55 +00:04:09,880 --> 00:04:14,700 +إمتى بتصير هذه إذا كانت كمية إمتى بتصير الأنيميا + +56 +00:04:14,700 --> 00:04:19,580 +صح الـ bone marrow بيشتغل لكن إذا فاق أو زاد كمية الفاقد + +57 +00:04:19,580 --> 00:04:22,980 +عن قدرة الـ bone marrow على إنه يعوضها فبيختل الـ balance + +58 +00:04:22,980 --> 00:04:27,140 +ما بين الفاقد وما بين الجديد أو المتكون أو المصنع + +59 +00:04:27,140 --> 00:04:31,820 +الجديد فبالتالي بينشأ عندنا نوع من الأنيميا النوع + +60 +00:04:31,820 --> 00:04:34,400 +الثالث أو المجموعة الثالثة اللي هي increase + +61 +00:04:34,400 --> 00:04:38,080 +destruction of RBCs ده كتير اللي هي بنسميها إحنا + +62 +00:04:38,080 --> 00:04:41,680 +hemolytic anemia هنا برضه الـ reticulocyte count + +63 +00:04:41,680 --> 00:04:48,460 +بيكون عالي ونفس الشيء نيجي للتصنيف الثاني اللي هي + +64 +00:04:48,460 --> 00:04:52,860 +حسب الـ morphology حسب الـ morphology في عندنا + +65 +00:04:52,860 --> 00:04:57,800 +normocytic normochromic anemia بداية طبعا قلنا + +66 +00:04:57,800 --> 00:05:03,850 +normocytic Micro-Cytic و Macro-Cytic ناخد أولا الـ + +67 +00:05:03,850 --> 00:05:08,410 +Normocytic Normocytic نورمو كروميك أنيميا هنا يعني + +68 +00:05:08,410 --> 00:05:13,590 +مافي خلل في الـ RBCs يعني الـ RBCs مافيش فيها + +69 +00:05:13,590 --> 00:05:16,430 +مشكلة خالص لا فيها نقص حديد ولا في خلل في حجمها + +70 +00:05:16,430 --> 00:05:21,570 +ولا في خلل في تصنيعها بس فيه بطء في عملية في خلل + +71 +00:05:21,570 --> 00:05:25,790 +معين ما أثر على الخلية وعلى وظيفتها لكن صار بطء في + +72 +00:05:25,790 --> 00:05:29,210 +تصنيع هذه الخلية في مشكلة في تصنيعها بس مش في + +73 +00:05:29,210 --> 00:05:32,670 +مكوناتها وفي قدرتها على العمل تمام فهذه الخلية + +74 +00:05:32,670 --> 00:05:37,150 +بتكون طبيعية Normocytic محتواها من الـ Hemoglobin + +75 +00:05:37,150 --> 00:05:43,890 +طبيعي تمام لكن في مشكلة زي مثلا Blood loss صار فقد + +76 +00:05:43,890 --> 00:05:47,310 +للدم الخلايا ما بتأثر شكلها ولا بتأثر الـ + +77 +00:05:47,310 --> 00:05:51,110 +Hemoglobin اللي فيها لكن بتأثر عددها تمام Hemolytic + +78 +00:05:51,110 --> 00:05:54,030 +Anemia أبلاستيك أنيميا أبلاستيك أنيميا الخلايا + +79 +00:05:54,030 --> 00:05:57,990 +بتتصنع خلايا كويسة لكن المشكلة إنه ما بتتصنع بالعدد + +80 +00:05:57,990 --> 00:06:00,990 +الكافي المناطق اللي بتشتغل في الـ bone marrow مش + +81 +00:06:00,990 --> 00:06:06,150 +كتيرة المناطق النشطة اللي بتصنع خلايا في حالات الـ + +82 +00:06:06,150 --> 00:06:08,730 +Chronic Diseases برضه في حالات الـ Renal + +83 +00:06:08,730 --> 00:06:09,490 +Insufficiency + +84 +00:06:15,800 --> 00:06:18,620 +الـ Renal Insufficiency اللي حكيناها طوي طبعا + +85 +00:06:18,620 --> 00:06:22,220 +بيصير خلل في الـ Erythrobiotin ما بتطلعش بشكل كافي + +86 +00:06:22,220 --> 00:06:25,420 +فبالتالي ما بيصيرش Stimulation للـ bone marrow + +87 +00:06:25,420 --> 00:06:29,000 +بشكل كافي وبالتالي ما بيطلعش خلايا كثيرة عشان ما + +88 +00:06:29,000 --> 00:06:34,440 +أرجع للشريحة هذه تمام نيجي للنوع الثاني Microcytic + +89 +00:06:34,440 --> 00:06:38,060 +وعادة الـ microcytic hypochromic بيكون كل الـ blood + +90 +00:06:38,060 --> 00:06:41,880 +indices قليلة الـ MCV له حجم الخلية قليل محتوى الـ + +91 +00:06:41,880 --> 00:06:46,880 +Hemoglobin MCH و MCHC برضه قليلة هذه المجموعة دائما + +92 +00:06:46,880 --> 00:06:49,940 +بنقول اللي هي بتشمل الـ Iron deficiency anemia + +93 +00:06:49,940 --> 00:06:53,060 +سيدرو بلاستيك أنيميا حالات الـ Lead poisoning + +94 +00:06:53,060 --> 00:06:59,120 +حالات الثلاسيميا حالات الـ Chronic diseases نيجي + +95 +00:06:59,120 --> 00:07:02,960 +للنوع الثالث اللي هو Macrocytic Normochromate + +96 +00:07:02,960 --> 00:07:09,640 +خلية كبيرة في الحجم MCV لها عالي والـ MCH والـ + +97 +00:07:09,640 --> 00:07:13,760 +MCHC ممكن تكون Normal لأن محتوى الـ Hemoglobin + +98 +00:07:13,760 --> 00:07:17,340 +يتناسب مع حجم الخلية في حالات الـ megaloplastic + +99 +00:07:17,340 --> 00:07:21,840 +anemia في حالات Liver disease في حالات بعد الـ + +100 +00:07:21,840 --> 00:07:25,560 +splenectomy في حالات الـ hypothyroidism في حالات + +101 +00:07:25,560 --> 00:07:28,340 +stress erythropoiesis يعني اللي بيقول مرة بيشتغل + +102 +00:07:28,340 --> 00:07:31,960 +تحت stress فبالتالي بيطلع خلايا لسه مش mature + +103 +00:07:31,960 --> 00:07:34,760 +كفاية اللي هي الـ reticulocyte اللي حكينا عنها + +104 +00:07:34,760 --> 00:07:39,180 +بتطلع بعدد كبير وطبعا هذه أكبر شوية من الـ RBCs + +105 +00:07:39,180 --> 00:07:43,600 +العادية فبالتالي بالمجمل بتزود الـ MCV بتاع الـ + +106 +00:07:43,600 --> 00:07:50,750 +blood بتاع الـ RBCs هنا تصنيف الخلايا حسب الـ + +107 +00:07:50,750 --> 00:07:55,710 +Morphology في عندي ثلاث صور من ثلاث أفلام واحد + +108 +00:07:55,710 --> 00:08:01,210 +فيهم Normal طبعا إذا فاكرين قلنا بنقيس الحجم بنواة + +109 +00:08:01,210 --> 00:08:06,150 +الـ Lymphocyte لأنه يعني بدي حاجة Standard أقيس + +110 +00:08:06,150 --> 00:08:09,790 +عليها فبعتبر نواة الـ Lymphocyte Standard لو أجينا + +111 +00:08:09,790 --> 00:08:13,980 +هنا هنلاقي الفيلم هذا «Norma 6» «Norma Comics» هنا + +112 +00:08:13,980 --> 00:08:17,980 +هنلاقي الخلايا الصغيرة Microcytic وبرضه كمية الـ + +113 +00:08:17,980 --> 00:08:21,120 +Hemoglobin فيها قليلة طبعا إذا كنتم فاكرين كمية + +114 +00:08:21,120 --> 00:08:24,960 +الـ Hemoglobin لازم أو المنطقة الفاضية عفوا ما + +115 +00:08:24,960 --> 00:08:29,220 +تزيدش عن طول الخلية زي هات لكن هنا المنطقة + +116 +00:08:29,220 --> 00:08:32,240 +الفاضية زادت عن طول الخلية فبسميها Hypochromic + +117 +00:08:32,240 --> 00:08:36,880 +هنا Microcytic Normochromic Microcytic لأنه زي ما + +118 +00:08:36,880 --> 00:08:40,920 +أنتم شايفين الخلايا كبيرة مقارنة بنواة الـ + +119 +00:08:40,920 --> 00:08:49,610 +lymphocyte معظمها خلايا Macrocytic تمام هيجي في أول + +120 +00:08:49,610 --> 00:08:53,870 +نوع Microcytic Hypochromic Anemia Microcytic + +121 +00:08:53,870 --> 00:08:57,770 +Hypochromic Anemia التصنيفات اللي حكيناهم طوي + +122 +00:08:57,770 --> 00:09:02,050 +هنبلش ناخدهم بالتفصيل وهيهمني أنا أكثر حاجة الـ + +123 +00:09:02,050 --> 00:09:05,470 +differential diagnosis لإياهم كيف بميزهم عن بعض + +124 +00:09:08,810 --> 00:09:13,730 +أول حاجة بتتميز هذه يعني في .. في لها صفات هتلاقي + +125 +00:09:13,730 --> 00:09:18,410 +إن الـ RBCs صغيرة كلها يعني الـ .. الـ .. الـ .. طبعا + +126 +00:09:18,410 --> 00:09:23,130 +Microcytic هيكون حجمها صغيرة المنطقة الوسطى اللي + +127 +00:09:23,130 --> 00:09:26,270 +هي الـ Central Palar Area هتلاقيها كبيرة لأنها + +128 +00:09:26,270 --> 00:09:31,530 +Microcytic Hypochromic Cells هذه الخلايا أو هذه + +129 +00:09:31,530 --> 00:09:37,150 +الحالات المرضية بتشمل Iron Deficiency Anemia + +130 +00:09:37,150 --> 00:09:41,420 +ثلاسيميا Anemia of Chronic Disease سيدروبلاستيك + +131 +00:09:41,420 --> 00:09:45,180 +أنيميا lead poisoning هذه صورة blood film زي ما + +132 +00:09:45,180 --> 00:09:49,020 +انتوا شايفين الخلايا الميتهيموجلبيين فيها قليلة + +133 +00:09:49,020 --> 00:09:54,020 +جدا بالإضافة لأن حجم الخلايا برضه صغير مقارنة + +134 +00:09:54,020 --> 00:10:00,320 +بنواة الليمفوسايت الآن + +135 +00:10:00,320 --> 00:10:03,920 +بشكل عام بالنسبة لـ Microcytic Hypochromic Anemia + +136 +00:10:04,750 --> 00:10:07,950 +طبعا احنا عارفين ان الـ Hemoglobin بتكون من Hem + +137 +00:10:07,950 --> 00:10:13,410 +-وغلوبين تمام؟ Hem-Globin قد يكون الخلل في + +138 +00:10:13,410 --> 00:10:18,590 +تصنيع الـ Hem نفسه الـ Hem مكون من Protoporphyrin + +139 +00:10:18,590 --> 00:10:24,590 +رينج 4 مع حديد صح؟ إذا صار الـ defect أو النقص في + +140 +00:10:24,590 --> 00:10:29,530 +كمية الحديد هتنتج عندي Iron deficiency أنيميا + +141 +00:10:29,530 --> 00:10:34,030 +وأحيانا برضه بتكون مصاحبة لـ chronic inflammation + +142 +00:10:34,030 --> 00:10:40,650 +أو أنيميا of a chronic disease طبعا لو صار في خلل + +143 +00:10:40,650 --> 00:10:46,110 +في تصنيع البروتوبورفيرين وتكونه برضه مش هيتكون + +144 +00:10:46,110 --> 00:10:50,350 +الهيم بشكل كافي فبالتالي بتنشأ عندي أو تتكون عندي + +145 +00:10:50,350 --> 00:10:53,940 +الـ Sideroblastic أنيميا بينما لو صار الخلل في + +146 +00:10:53,940 --> 00:10:57,000 +الغلوبين الـ Chain Alpha أو Beta تطلع عندي + +147 +00:10:57,000 --> 00:11:03,720 +الثلاسيميا طبعا والأنواع هذه كلها تتميز بأنها + +148 +00:11:03,720 --> 00:11:07,280 +Microcytic Hypochromic هنا بنحكي عن الأسباب يعني إما + +149 +00:11:07,280 --> 00:11:10,820 +خلل في تصنيع الهيم أو الغلوبين الهيم قد يكون سببه + +150 +00:11:10,820 --> 00:11:15,260 +مشكلة بالـ Iron أو مشكلة بالبروتوبرفرين كل واحدة + +151 +00:11:15,260 --> 00:11:17,720 +بتطلع عندي نوع مختلف من الأنيميا + +152 +00:11:20,430 --> 00:11:24,810 +هنا لو تخيلنا هذا Normal Red Blood Cell Maturation هذا + +153 +00:11:24,810 --> 00:11:29,450 +الحجم الطبيعي للخلايا خلال الـ Maturation لكن الـ + +154 +00:11:29,450 --> 00:11:32,670 +Microcytic Anemia هتبقى الخلايا من الأساس هتبقى + +155 +00:11:32,670 --> 00:11:36,410 +صغيرة ويصير الـ Differentiation وتطلع عندي بالآخر + +156 +00:11:36,410 --> 00:11:42,550 +mature erythrocyte توصف بأنها Microcytic Cell + +157 +00:11:42,550 --> 00:11:47,530 +دعونا نبدأ بالـ Iron Deficiency Anemia لأن هي أكثر + +158 +00:11:47,530 --> 00:11:51,700 +أنواع الأنيميا انتشارا الـ Iron deficiency anemia + +159 +00:11:51,700 --> 00:11:55,220 +تنتج + +160 +00:11:55,220 --> 00:12:01,800 +من نقص الحديد في الجسم طبعا هينعكس على الـ Serum + +161 +00:12:01,800 --> 00:12:07,460 +Iron هنلاقي فيه نقص طبعا نقص الحديد هيؤدي لخلل في + +162 +00:12:07,460 --> 00:12:11,540 +تصنيع الهيم وبالتالي نقص في الـ Hemoglobin وهذا + +163 +00:12:11,540 --> 00:12:16,300 +ينتج عنه Iron deficiency anemia تشكل أكثر من + +164 +00:12:16,300 --> 00:12:17,040 +نصف الحالات + +165 +00:12:19,650 --> 00:12:22,610 +السبب الأول والرئيسي اللي هو Nutritional + +166 +00:12:22,610 --> 00:12:26,170 +Deficiency طبيعة الأكل، الاهتمام بالخضار، + +167 +00:12:26,170 --> 00:12:28,770 +بالفواكه، باللحوم، بالعناصر الغذائية، الهمة + +168 +00:12:28,770 --> 00:12:33,130 +بالطعام طيب، في ناس تيجي بتقولك أنا أكل كويس + +169 +00:12:33,130 --> 00:12:37,590 +ومتوازن لكن هي بتلاقي الدم عندها الـ Hemoglobin + +170 +00:12:37,590 --> 00:12:41,930 +عندها ما بيرتفع ممكن يكون سببها إن في عندهم + +171 +00:12:41,930 --> 00:12:46,140 +Malabsorption، في خلل في امتصاص الحديد هذا يعني + +172 +00:12:46,140 --> 00:12:50,640 +ممكن يكون خلل طبيعي يعني أو يعني مخلوق فيه عيب + +173 +00:12:50,640 --> 00:12:54,560 +خلقي إنه في عندها الحديد ما بينتصب بشكل جيد أو + +174 +00:12:54,560 --> 00:12:59,660 +نتيجة عادة غذائية سيئة يعني مثلا إحنا عارفين إنه + +175 +00:12:59,660 --> 00:13:03,100 +بالـ Calcium والحديد الـ Calcium بيعكس على الحديد + +176 +00:13:03,100 --> 00:13:07,380 +صح أو إنه مثلا بعد لو الوجبات اللي فيها الحديد + +177 +00:13:07,380 --> 00:13:11,760 +بتاخد شاي الشاي بيأثر على امتصاص الحديد فيعني هذه قصة + +178 +00:13:11,760 --> 00:13:16,180 +الـ Absorption inefficient transport storage or + +179 +00:13:16,180 --> 00:13:19,080 +Utilization of Iron يعني فيه مشكلة في نقل الحديد + +180 +00:13:19,080 --> 00:13:22,380 +وفي تخزينه وفي الـ utilization تبعه واستهلاكه في الجسم + +181 +00:13:22,380 --> 00:13:29,080 +Increased Need يعني في حاجة زائدة أو فائدة للحديد + +182 +00:13:29,080 --> 00:13:34,080 +في الجسم Chronic Blood Loss الفاقد بزيادة زي ما + +183 +00:13:34,080 --> 00:13:39,740 +يكون فيه نزيف أو Ulcer أو Heavy Menstruation طبعا + +184 +00:13:39,740 --> 00:13:43,930 +عارفين مصادر الحديد قد تكون حيوانية وقد تكون نباتية + +185 +00:13:43,930 --> 00:13:49,950 +بيبين + +186 +00:13:49,950 --> 00:13:54,670 +ايش الاحتياج اليومي للحديد حسب الفئة العمرية وحسب + +187 +00:13:54,670 --> 00:14:00,510 +التوزيع الـ Iron في الجسم هذه كويسة يعني عندنا ال + +188 +00:14:00,510 --> 00:14:04,830 +Iron موجود 65% بيكون منه في الهيموجلوبين في ال + +189 +00:14:04,830 --> 00:14:09,460 +هيموجلوبين عفوا في الريتين والهيموسيدرين كمخزون + +190 +00:14:09,460 --> 00:14:13,180 +بنلاقي 30 تقريبا في المية الـ Myoglobin بنلاقي + +191 +00:14:13,180 --> 00:14:16,200 +فيه 3.5 في المية الـ Hem Enzymes تقريبا نصف + +192 +00:14:16,200 --> 00:14:20,200 +في المية هنا 0.1 Transferrin Bound Iron + +193 +00:14:20,200 --> 00:14:25,720 +بتلاقي كمية من الحديد مرتبطة فيه داخل الـ Iron + +194 +00:14:25,720 --> 00:14:31,020 +Deficiency Anemia طبعا لو صار فيه فقد للـ Iron أو + +195 +00:14:34,480 --> 00:14:38,040 +يعني إنه احنا محتاجين حديد بزيادة في الجسم زيادة + +196 +00:14:38,040 --> 00:14:42,580 +التصنيع أو هيك شيء طبعا هيصير استهلاك بزيادة + +197 +00:14:42,580 --> 00:14:46,780 +للحديد وإذا كان الإنسان ما بياخدش الكمية الكافية عن + +198 +00:14:46,780 --> 00:14:50,540 +طريق الغذاء هتبدأ تتطور عنده الـ Iron Deficiency + +199 +00:14:50,540 --> 00:14:56,680 +Anemia أول حاجة مرحلة إنه يعني الـ Peripheral Blood + +200 +00:14:56,680 --> 00:15:00,380 +والـ RBCs ما بتتغير وحتى الـ Serum ما بتتغير فيه + +201 +00:15:00,380 --> 00:15:03,860 +منسوب الحديد بيبدأ ينقص وين في الـ Stores احنا + +202 +00:15:03,860 --> 00:15:06,960 +عارفين إنه الـ Stores بتاعة الحديد في الأنسجة + +203 +00:15:06,960 --> 00:15:10,960 +الـ Ferritin فالـ Ferritin بيكون نسبة بسيطة منه + +204 +00:15:10,960 --> 00:15:15,240 +في الـ Blood بسيطة جدا يعني وفي توازن مع لف الأنسجة + +205 +00:15:15,240 --> 00:15:18,780 +فلو نقص في الـ Serum معنى الكلام إنه صار فيه نقص + +206 +00:15:18,780 --> 00:15:23,100 +في الحديد المخزن يعني أول حاجة بيبدأ الحديد من وين + +207 +00:15:23,100 --> 00:15:27,620 +يسحب يسحب من المخزون من الـ Ferritin وهذا بينعكس على + +208 +00:15:27,620 --> 00:15:32,800 +الـ Ferritin الموجود بالسيرام يعني أول مرحلة أن الـ Serum + +209 +00:15:32,800 --> 00:15:36,720 +Iron بيكون طبيعي بياخد Iron من المخزن الـ Total + +210 +00:15:36,720 --> 00:15:40,540 +Iron Binding Capacity طبيعية مافيش أنيميا، مافيش + +211 +00:15:40,540 --> 00:15:44,100 +أي أعراض الـ RBCs Normal نورموسيتيك، نورموكروميك + +212 +00:15:44,100 --> 00:15:48,520 +لكن وين بتبدأ تبين المشكلة؟ في الـ Ferritin بيكون الـ + +213 +00:15:48,520 --> 00:15:52,400 +Serum Ferritin قليل لأن هنا بلش الحديد ينسحب + +214 +00:15:52,400 --> 00:15:56,720 +من الـ Iron Stores بيتبلش ينسحب من المخازن فبيبدأ + +215 +00:15:56,720 --> 00:16:01,680 +ينقص الـ Ferritin المرحلة الثانية بيبدأ ينقص الـ + +216 +00:16:01,680 --> 00:16:05,730 +Serum Iron بس لسه الـ RBCs ما اتغيرت Serum Iron + +217 +00:16:05,730 --> 00:16:09,970 +بنقص الـ Total Iron Binding Capacity بتنقص وبرضه + +218 +00:16:09,970 --> 00:16:15,530 +خدوبة لكم الـ Ferritin من الأساس هو اصلا ناقص لكن ما + +219 +00:16:15,530 --> 00:16:19,330 +بيكون لسه فيه أنيميا الـ RBC's بتكون طبيعية المرحلة + +220 +00:16:19,330 --> 00:16:25,730 +الثالثة إنه يعني خلاص انسحبت المخازن والحديد اللي + +221 +00:16:25,730 --> 00:16:29,750 +بيتاخد ما بيكفي إنه نصنع Hemoglobin كويس فبنعدي + +222 +00:16:29,750 --> 00:16:34,010 +في المرحلة الثالثة اللي هي مرحلة الأنيميا الحقيقية + +223 +00:16:34,010 --> 00:16:38,010 +إنه الـ Iron Stores فضيت الحديد نزل في الـ Serum + +224 +00:16:38,010 --> 00:16:41,150 +فبالتالي بتبدأ الأنيميا تظهر اللي هي Microcytic + +225 +00:16:41,150 --> 00:16:45,150 +Hypochromic Anemia أو Microcytic Hypochromic Red + +226 +00:16:45,150 --> 00:16:49,290 +Cells وبتنشأ حالة Iron Deficiency Anemia يعني مش + +227 +00:16:49,290 --> 00:16:53,630 +من أول ما بيبدأ ينقص الـ Iron بنبدأ احنا لل + +228 +00:16:53,630 --> 00:16:57,970 +Symptoms بتاعة الـ Iron Deficiency Anemia طبعا فينا + +229 +00:16:57,970 --> 00:17:02,110 +Fatigue, Dizziness, Headache فينا برضه بعض ال + +230 +00:17:02,110 --> 00:17:05,030 +Signs المميزة للـ Iron Deficiency Anemia زي ال + +231 +00:17:05,030 --> 00:17:12,670 +Smooth Tongue زي الـ Stomatitis اللي هي في الأظافر + +232 +00:17:12,670 --> 00:17:19,950 +وتشققات طبعا هذا من علامات الـ Iron نيجي للـ Lab + +233 +00:17:19,950 --> 00:17:24,190 +Diagnosis of Iron Deficiency أنيميا فحوصات خاصة + +234 +00:17:24,190 --> 00:17:28,310 +بالحديد فحوصات خاصة بالحديد هذه ممكن نستخدمها عشان + +235 +00:17:28,310 --> 00:17:32,090 +نعمل Differential Diagnosis للـ Microcytic + +236 +00:17:32,090 --> 00:17:34,890 +Hypochromic أنيميا لأنواعها المختلفة ميزها عن + +237 +00:17:34,890 --> 00:17:38,670 +بعض أو إذا كان في Iron Overload إذا كان في زيادة + +238 +00:17:38,670 --> 00:17:42,330 +في الـ Iron برضه ممكن نقيس الـ Iron طيب قبل ما نبدأ + +239 +00:17:42,330 --> 00:17:45,810 +نحكي في الـ Iron Test لنفهم شغلة مهمة كثير إنه أنا + +240 +00:17:45,810 --> 00:17:51,630 +اللي بقيسه Iron مرتبط بحاجة اسمها Transferrin ايش + +241 +00:17:51,630 --> 00:17:54,770 +هو الـ Transferrin؟ هو عبارة عن بروتين ناقل + +242 +00:17:54,770 --> 00:17:59,470 +للحديد، تمام؟ عادة للـ Transferrin هذا بلاقي منه + +243 +00:17:59,470 --> 00:18:06,050 +33% مرتبط بالـ Iron والباقي بيكون غير مرتبط، كويس؟ + +244 +00:18:06,050 --> 00:18:11,420 +طيب، فأنا عندي تحوصات بعملها الـ Serum Iron الـ + +245 +00:18:11,420 --> 00:18:15,900 +Serum Iron يا بنات هو فعليا الـ Serum Iron + +246 +00:18:15,900 --> 00:18:18,680 +الـ Iron المرتبط بالـ Transferrin يعني أنا هي هذه + +247 +00:18:18,680 --> 00:18:24,600 +الـ 33% بدي أقدر قد ايش .. قد ايش هي تركيزها تمام الـ + +248 +00:18:24,600 --> 00:18:30,320 +Total Iron Binding Capacity هذه بأقيس فيها قد ايش في + +249 +00:18:30,320 --> 00:18:34,860 +عندي حديد قادر يرتبط بـ Transferrin بمعنى آخر قد ايش + +250 +00:18:34,860 --> 00:18:41,010 +في عندي Transferrin Free كل ما كان الحديد أقل تمام، + +251 +00:18:41,010 --> 00:18:44,490 +هيكون الـ Transferrin Free أكثر فهذه علاقتها عكسية + +252 +00:18:44,490 --> 00:18:51,490 +مع الـ Iron طيب، Serum Iron Level بداية قلت لكم + +253 +00:18:51,490 --> 00:18:54,690 +هو بنقيس من خلالها الـ Iron المرتبط بالـ + +254 +00:18:54,690 --> 00:18:59,530 +Transferrin طبعاً ما بنقيس الـ Iron لـ Free، بنقيس + +255 +00:18:59,530 --> 00:19:04,430 +المرتبط Total Iron Binding Capacity زي ما قلنا، هي + +256 +00:19:04,430 --> 00:19:07,700 +عبارة عن indirect measured من الـ amount of + +257 +00:19:07,700 --> 00:19:10,240 +transferrin protein in the serum الترانسفيرين + +258 +00:19:10,240 --> 00:19:13,600 +الموجود اللي مش مرتبط اللي موجود بالـ serum طبعاً + +259 +00:19:13,600 --> 00:19:16,700 +و بديهي زي ما قلنا هناك علاقة عكسية كل ما كان + +260 +00:19:16,700 --> 00:19:20,420 +الحديد أكثر كل ما كان الـ transferrin free أقل كل + +261 +00:19:20,420 --> 00:19:23,020 +ما كان الحديد قليل زي حالات الـ iron deficiency + +262 +00:19:23,020 --> 00:19:26,540 +أنيميا هتلاقي الـ transferrin زاد فبالتالي هي + +263 +00:19:26,540 --> 00:19:29,340 +الـ transferrin بتعبر عنها الـ total iron binding + +264 +00:19:29,340 --> 00:19:33,440 +capacity فبالتالي هيكون تناسب عكسي ما بين الـ TIBC + +265 +00:19:33,440 --> 00:19:37,840 +وما بين الـ iron في الجسم If serum iron is + +266 +00:19:37,840 --> 00:19:40,440 +decreased, total iron binding capacity of + +267 +00:19:40,440 --> 00:19:43,940 +transferrin increases. Transferrin has more empty + +268 +00:19:43,940 --> 00:19:47,700 +space to carry iron يعني فيه فراغات أو أماكن فاضية + +269 +00:19:47,700 --> 00:19:53,920 +شاغرة من الـ iron نتيجة نقص الـ iron بالسيروم نيجي + +270 +00:19:53,920 --> 00:19:58,460 +للسيروم فريتين طبعا الفريتين هو بروتين بيتحكم في + +271 +00:19:58,460 --> 00:20:04,240 +تخزين الحديد الفريتين هذا يعني موجود بشكل أساسي في + +272 +00:20:04,240 --> 00:20:07,700 +الأنسجة موجود كمية بسيطة منه في الـ blood لكن + +273 +00:20:07,700 --> 00:20:11,460 +الكمية اللي في الـ blood بتعكس عند صورة الموجود في + +274 +00:20:11,460 --> 00:20:16,240 +الأنسجة Found interest amount in plasma it is in + +275 +00:20:16,240 --> 00:20:19,080 +equilibrium with the body stores يعني فيه تناسب كل + +276 +00:20:19,080 --> 00:20:22,880 +ما كانت كميته كل ما قلت كميته في الـPlasma أو في + +277 +00:20:22,880 --> 00:20:25,920 +الـSerum أو في الـPlasma معنى الكلام إنه نقص في + +278 +00:20:25,920 --> 00:20:29,960 +نقص الـIron stores أو نقص الحديد في مخازنه في + +279 +00:20:29,960 --> 00:20:33,740 +الأنسجة Variation in the quantity of iron in the + +280 +00:20:33,740 --> 00:20:36,000 +storing environment is reflected by plasma + +281 +00:20:36,000 --> 00:20:38,460 +ferritin concentration نفس الكلام اللي قلناه يعني + +282 +00:20:38,460 --> 00:20:42,420 +لو نقص الحديد في المخزون الحديد في الأنسجة بنقص + +283 +00:20:42,420 --> 00:20:47,180 +الـ ferritin اللي موجود في البلازما كم تبقى نقص؟ في + +284 +00:20:47,180 --> 00:20:51,280 +مراحل مبكرة من الـ iron deficiency أنيميا و بيزيد في + +285 +00:20:51,280 --> 00:20:56,460 +حالات الأنيميا أو الـ chronic disease طبعا فينا هنا + +286 +00:20:56,460 --> 00:21:00,040 +ملاحظة بس بدنا نأخذ بالنا منها بقول لك في بعض حالات + +287 +00:21:00,040 --> 00:21:03,280 +الـ infection أو الـ inflammation Serum ferritin في الـ + +288 +00:21:03,280 --> 00:21:08,900 +سيروم بيزيد لأنه عبارة عن acute phase protein من + +289 +00:21:08,900 --> 00:21:11,780 +البروتينات اللي بتطلع في الـ acute phase + +290 +00:21:11,780 --> 00:21:17,830 +inflammation أو infection طبعا هنا يعني هذه تعتبر + +291 +00:21:17,830 --> 00:21:21,310 +Indicator مش كتير صحيح أو الـ ferritin يعتبر + +292 +00:21:21,310 --> 00:21:24,190 +Indicator مش كتير صحيح عن وضع الحديد في حالات الـ + +293 +00:21:24,190 --> 00:21:26,790 +inflammation بس بدي آخذ بالي لو في acute + +294 +00:21:26,790 --> 00:21:31,130 +inflammation أجل موضوع قياس الـ ferritin شوية فلنش + +295 +00:21:31,130 --> 00:21:37,390 +يعطيني pause ابون مارو آيرون يعني احنا خلصنا هيك + +296 +00:21:37,390 --> 00:21:41,740 +حكينا عن الـ Serum Iron بنقيس المحتوى الحديد أو + +297 +00:21:41,740 --> 00:21:46,100 +دراسة الحديد الـ Iron Profile بنسميه بنقيس الـ + +298 +00:21:46,100 --> 00:21:49,320 +Iron بنقيس الـ Total Iron Binding Capacity اللي + +299 +00:21:49,320 --> 00:21:52,880 +بتعبر عن الـ transferrin بنقيس الـ ferritin خلصنا منهم + +300 +00:21:52,880 --> 00:21:56,120 +فلقيت الـ Bone Marrow Iron كيف بده أشوف الـ Bone + +301 +00:21:56,120 --> 00:22:00,160 +Marrow وضع الـ Iron فيه أول حاجة issue biopsy of + +302 +00:22:00,160 --> 00:22:04,380 +bone marrow ممكن بالبرلسيان بلوستين هذه صبغة خاصة + +303 +00:22:04,380 --> 00:22:08,780 +بالحديد type of iron موجود في البونمارو هو + +304 +00:22:08,780 --> 00:22:13,300 +الهيموسيدرين يخزن في البونمارو على شكل هيموسيدرين + +305 +00:22:13,300 --> 00:22:20,860 +هنا صورة هي هذه normal شايفين هذه صبغة الـ Prussian + +306 +00:22:20,860 --> 00:22:25,560 +Blue بتصبغ مخزن الحديد الهيموسيدرين هنا مش موجود في + +307 +00:22:25,560 --> 00:22:27,980 +حالة الـ iron deficiency مافيش عندي اللون الأزرق + +308 +00:22:27,980 --> 00:22:32,640 +خالص معناه الكلام ان في عندي أنيميا Iron deficiency + +309 +00:22:32,640 --> 00:22:38,660 +anemia طيب نيجي للـ lab finding في الـ Iron + +310 +00:22:38,660 --> 00:22:45,520 +deficiency anemia low كل شيء low كل شيء low ما عدا + +311 +00:22:45,520 --> 00:22:49,600 +الـ white cells و الـ platelets الـ RBCs hemoglobin + +312 +00:22:49,600 --> 00:22:55,900 +hematocrit low الـ MCV الـ MCH الـ MCHC برضه low ليش؟ + +313 +00:22:55,900 --> 00:22:59,780 +لأن حجم الخلايا صغير ومحتواها من الـ hemoglobin صغير + +314 +00:22:59,780 --> 00:23:04,620 +تمام؟ يعني لو جينا لهذا الـ CBC الـ White cells طبعا + +315 +00:23:04,620 --> 00:23:09,020 +الـ Platelets ما راح تتأثر الـ RBCs 2.9، + +316 +00:23:09,020 --> 00:23:16,400 +Hemoglobin 6.3، Hematocrit 24، MCV 69، MCH 1 يعني + +317 +00:23:16,400 --> 00:23:20,400 +كل الـ Parameters قليلة مع ذلك الـ Platelets و الـ + +318 +00:23:20,400 --> 00:23:27,160 +RBCs و الـ .. مع ذلك الـ Platelets و الـ .. و الـ White + +319 +00:23:27,160 --> 00:23:27,460 +cells + +320 +00:23:32,520 --> 00:23:36,240 +الـ RBCs مورفولوجي لو احنا عملنا Blood Film بنلاقي + +321 +00:23:36,240 --> 00:23:40,100 +hypochromic microcytic cells بنلاقي anisocytosis + +322 +00:23:40,100 --> 00:23:44,020 +يعني التغير في أحجام الخلايا poikilocytosis ممكن + +323 +00:23:44,020 --> 00:23:47,100 +أشوف اللي هي الـ Pencil Cell خلية الـ Cigar Cell + +324 +00:23:47,100 --> 00:23:52,660 +خلية رفيعة كتير يعني زي الـ Elliptocyte برضه ممكن + +325 +00:23:52,660 --> 00:23:58,160 +أشوف Target Cell طبعاً ما بشوفش inclusion bodies في + +326 +00:23:58,160 --> 00:24:03,240 +الـ RBCs خالص Iron Parameters هلاقي الـ Iron لو الـ + +327 +00:24:03,240 --> 00:24:06,580 +Total Iron Binding Capacity عالي الـ Serum ferritin + +328 +00:24:06,580 --> 00:24:12,320 +هلاقيها قليل هاي + +329 +00:24:12,320 --> 00:24:15,180 +عندنا Blood Film زي ما أنتم شايفين الخلايا كلها + +330 +00:24:15,180 --> 00:24:20,090 +تقريباً صغيرة هو احنا هنا ما فيش عندنا الانفوسايت + +331 +00:24:20,090 --> 00:24:23,970 +نقارن فيها لكن هو بيقول لي ان الخلايا كلها صغيرة في + +332 +00:24:23,970 --> 00:24:26,910 +عندي الـ Elliptocyte اللي هي الـ Pencil Cell في عندي + +333 +00:24:26,910 --> 00:24:31,130 +الـ Ovalocyte هذه الـ Elliptocyte مش Ovalocyte هي هذه + +334 +00:24:31,130 --> 00:24:34,210 +الـ Ovalocyte فاكرين كيف بنفرق من الـ Oval و + +335 +00:24:34,210 --> 00:24:40,510 +الـ Ellipto؟ الـ Ellipto بتكون أرفع بحيث أن عرضها هذا + +336 +00:24:40,510 --> 00:24:45,930 +أقل من طولها أقل من ضعف طولها فهمتوا؟ عرضها أقل من + +337 +00:24:45,930 --> 00:24:51,300 +ضعف طولها بتكون الـ Leptocyte إذا كان عرضها أكثر من + +338 +00:24:51,300 --> 00:24:56,240 +ضعف طولها بتكون Ovalocyte و شايفين الـ Hypochromia + +339 +00:24:56,240 --> 00:24:58,920 +الواضحة في الخلايا إذن Anisocytosis and + +340 +00:24:58,920 --> 00:25:06,420 +Poikilocytosis ما فيش inclusion bodies طيب + +341 +00:25:06,420 --> 00:25:11,240 +نيجي للـ Sideroblastic Anemia Sideroblastic Anemia + +342 +00:25:11,240 --> 00:25:14,180 +يمكن أنا نوّهت في البداية في الـ Iron Deficiency + +343 +00:25:14,580 --> 00:25:19,160 +و الـ Sideroblastic بفرق بين التنين في شغلة أن + +344 +00:25:19,160 --> 00:25:22,300 +التنين فيه خلل في تصنيع الـ hemoglobin وبالتالي الـ + +345 +00:25:22,300 --> 00:25:27,260 +Hemoglobin لكن الـ Iron deficiency الخلل في الحديد + +346 +00:25:27,260 --> 00:25:30,000 +الـ Sideroblastic في الـ protoporphyrin اللي بيكون + +347 +00:25:30,000 --> 00:25:33,880 +الـ protoporphyrin ring بتاعة الـ hemoglobin هي عبارة عن جروب + +348 +00:25:33,880 --> 00:25:37,700 +من الأنميا تتميز فيه defective protoporphyrin + +349 +00:25:37,700 --> 00:25:41,960 +synthesis طبعا هذا منتج عنه iron loading زيادة + +350 +00:25:41,960 --> 00:25:45,600 +للحديد الحديد ما فيش فيه مشكلة لكن لأن الـ + +351 +00:25:45,600 --> 00:25:49,740 +Hemoglobin مش هيتصنع الحديد موجود، الـ Hemoglobin + +352 +00:25:49,740 --> 00:25:53,220 +مش هيتصنع فهيبدأ يتراكم الحديد ويزيد عكس الـ Iron + +353 +00:25:53,220 --> 00:25:56,460 +deficiency anemia تنتج عندنا Hypochromic anemia + +354 +00:25:56,460 --> 00:26:00,360 +نتيجة نقص تصنيع الـ Hemoglobin الـ blocks in + +355 +00:26:00,360 --> 00:26:03,920 +protoporphyrin synthesis lead to iron overload and + +356 +00:26:03,920 --> 00:26:06,860 +microcytic hypochromic anemia ملخص الـ + +357 +00:26:06,860 --> 00:26:07,540 +Sideroblastic + +358 +00:26:14,240 --> 00:26:18,300 +Siderocyte هي عبارة عن mature red blood cells هذه في + +359 +00:26:18,300 --> 00:26:20,820 +الوضع الطبيعي أنا ما بشوفهاش في الـ Peripheral + +360 +00:26:20,820 --> 00:26:27,720 +blood هي خلية فيها بقايا حديد granules متخزنة في + +361 +00:26:27,720 --> 00:26:31,020 +الـ mitochondria بتاعة الخلايا طبعا هذه أنا في + +362 +00:26:31,020 --> 00:26:34,340 +الوضع الطبيعي ما بشوفها إذا كنتم فاكرين لما حكينا + +363 +00:26:34,340 --> 00:26:37,840 +عن الـ inclusion bodies حكينا فيه ترسبات حديد + +364 +00:26:37,840 --> 00:26:40,620 +أحياناً تظهر في الخلية في بعض الحالات المرضية + +365 +00:26:40,620 --> 00:26:44,770 +سميناها Pappenheimer bodies الخلية اللي فيها + +366 +00:26:44,770 --> 00:26:48,550 +الـ Pappenheimer bodies هذه بسميها Siderocyte وهذه مميزة + +367 +00:26:48,550 --> 00:26:54,150 +يعني لحالات Sideroblastic Anemia ليش؟ لأن فيه زيادة + +368 +00:26:54,150 --> 00:26:58,510 +في الحديد Sideroblast هي عبارة عن Immature + +369 +00:26:58,510 --> 00:27:02,550 +nucleated RBCs in the bone marrow هيكون فيها كمية + +370 +00:27:02,550 --> 00:27:06,230 +من الحديد في الـ Cytoplasm هذه بتكون موجودة بشكل + +371 +00:27:06,230 --> 00:27:10,070 +طبيعي Sideroblast ليش؟ لأن الحديد طبيعي موجود في + +372 +00:27:10,070 --> 00:27:13,610 +الـ bone marrow و متخزن لكن إذا كانت بتكون Abnormal + +373 +00:27:13,610 --> 00:27:23,690 +شكل Ring Iron form a ring around the nucleus إذا + +374 +00:27:23,690 --> 00:27:27,910 +كان الحديد متخزن على شكل دائرة حول النواة هذه + +375 +00:27:27,910 --> 00:27:32,790 +تعتبر حالة مميزة لـ Sideroblastic Anemia و بسمي + +376 +00:27:32,790 --> 00:27:37,670 +الخلية في هذه الحالة Ring Sideroblast + +377 +00:27:37,670 --> 00:27:40,410 +Sideroblast هنا Sideroblastic Anemia characterised + +378 +00:27:40,410 --> 00:27:43,370 +by the accumulation of iron in the mitochondria of + +379 +00:27:43,370 --> 00:27:46,670 +immature nucleated RBCs in the bone marrow على شكل + +380 +00:27:46,670 --> 00:27:51,590 +الـRing بسميها Ring Sideroblast وبتعتبر علامة مميزة + +381 +00:27:51,590 --> 00:27:53,730 +بعيد لـSideroblastic Anemia + +382 +00:27:56,460 --> 00:28:00,320 +طيب نيجي للـ Lab finding في الـ Sideroblastic + +383 +00:28:00,320 --> 00:28:04,720 +Anemia طبعا زي ما اتفقنا هيكون كل إشي قليل واطي + +384 +00:28:04,720 --> 00:28:08,040 +Microcytic Hypochromic Anemia الـ MCV الـ MCHC + +385 +00:28:08,040 --> 00:28:12,220 +الانيميا هتكون variable اللي هو reticulocyte count + +386 +00:28:12,220 --> 00:28:15,700 +لأن احنا اتفقنا هدول ال reticulocyte بيكون قليل + +387 +00:28:15,700 --> 00:28:19,420 +فيها ال iron deficiency و الحاجات اللي لها علاقة + +388 +00:28:19,420 --> 00:28:22,340 +بال nutritional مع ال Sideroblastic Anemia هتبتبت + +389 +00:28:22,340 --> 00:28:25,480 +تبقى reticulocyte قليلةاللي بيبقى فيه مشكلة في + +390 +00:28:25,480 --> 00:28:29,240 +تصنيع الـBlood نفسه الـHemoglobin والـRBCs طيب + +391 +00:28:29,240 --> 00:28:35,020 +RBCs Inclusions عادة ممكن أشوف بيزوفيليكستبلينج + +392 +00:28:35,020 --> 00:28:38,320 +أشهى الـBasophilic Stippling؟ هي بقايا ريبوزاما + +393 +00:28:38,320 --> 00:28:44,140 +الـRNA and ببنهاي مربادز اللي هي الـSiderocytes ممكن + +394 +00:28:44,140 --> 00:28:49,300 +أشوف في بعض الأحيان Target Cells طيب بتتميز بإيش + +395 +00:28:49,300 --> 00:28:53,310 +هذه؟ نيجي لفحوصات الـSerumالـ Iron كيف هيكون؟ أكيد + +396 +00:28:53,310 --> 00:28:57,310 +هيكون عالي لأنه متراكم تمام؟ الـ Serum Ferritin + +397 +00:28:57,310 --> 00:29:00,290 +برضه عالي لكن الـ Total Iron Binding Capacity + +398 +00:29:00,290 --> 00:29:05,750 +هيكون Low ليش؟ لأن الـ Transferrin الموجود هيكون + +399 +00:29:05,750 --> 00:29:09,530 +مرتبط لأنه حديد كتير فبالتالي الـ Total Iron + +400 +00:29:09,530 --> 00:29:12,990 +Binding Capacity هي ببساطة قدرة الـ Transferrin + +401 +00:29:12,990 --> 00:29:17,590 +على ارتباط بالـ Ironطيب، decreased transferrin + +402 +00:29:17,590 --> 00:29:21,390 +synthesis occurs in iron-overlaid states يعني هيكون + +403 +00:29:21,390 --> 00:29:28,170 +فيه برضه نقص في تصنيع الترانسفيرين وهذا بنعاكس في + +404 +00:29:28,170 --> 00:29:32,230 +الـ Total Iron Binding Capacity اللوه بون مارو + +405 +00:29:32,230 --> 00:29:35,150 +بشوف في الـ Ring Sideroblast ومرة تانية بقول + +406 +00:29:35,150 --> 00:29:37,950 +Hallmark of Sideroblastic Anemia قلت لهم بجيبها + +407 +00:29:37,950 --> 00:29:39,190 +بالامتحان وما بتعرفوهاش + +408 +00:29:41,860 --> 00:29:46,600 +هنا عندنا شوية صور في عندى البابنهايمر body + +409 +00:29:46,600 --> 00:29:49,900 +Pappenheimer body زى ما انتوا شايفين عبارة عن زى + +410 +00:29:49,900 --> 00:29:53,740 +clusters بتكون في الخلية زى براد الحديد تجمعات من + +411 +00:29:53,740 --> 00:29:56,920 +الحديد هذا الـ Sideroblast العادية انها شوف فيها + +412 +00:29:56,920 --> 00:30:00,920 +iron granules أما تزيد ال granules و تصير لها تجمع + +413 +00:30:00,920 --> 00:30:04,380 +حوالين النواء هذا بدل على انها Sideroblastic anemia + +414 +00:30:04,380 --> 00:30:11,160 +هى عندى الصورة الحقيقية لها هى البابنهايمر bodyهي + +415 +00:30:11,160 --> 00:30:15,920 +الـ Sideroblast انه تجمع عادي للحديد حوالين الخلية + +416 +00:30:15,920 --> 00:30:19,460 +لكن لما يكون بهذا الشكل بقول هذه غالبا + +417 +00:30:19,460 --> 00:30:25,220 +Sideroblastic Anemia هاي عندنا مجموعة صور كمان هاي + +418 +00:30:25,220 --> 00:30:28,320 +هادي Basophilic Stippling هادي Pappenheimer bodies + +419 +00:30:28,320 --> 00:30:34,000 +هادي برضه بس هنا varieties تانية بنات هنا + +420 +00:30:34,000 --> 00:30:36,600 +بالبرجياني blue stain علشان هيك ظهرت بهذا اللون + +421 +00:30:36,600 --> 00:30:43,620 +اللي هي ال Pappenheimer bodiesطيب البولمارو إيش + +422 +00:30:43,620 --> 00:30:47,760 +قلنا بنشوف فيه؟ بنشوف فيه ring Sideroblast وبشوف + +423 +00:30:47,760 --> 00:30:53,760 +macrophages كبيرة مصبوغة بالمخ تصبغة الحديد ليش؟ + +424 +00:30:53,760 --> 00:30:56,280 +لأنه هتلاقي يعني البولمارو اللون بتاعه لما أصبغ + +425 +00:30:56,280 --> 00:30:59,780 +بليبروجيني blue ماخد أو مكتسح اللون الأزرق لأن + +426 +00:30:59,780 --> 00:31:05,580 +الحديد فيه بزيادة ثاني شيء لنوع آخر من أنواع + +427 +00:31:05,580 --> 00:31:08,780 +الانيميا اللي بتكون غالبا microcytic micro + +428 +00:31:08,780 --> 00:31:13,650 +hypochromicاللي هي Anemia of Chronic Disease هنا + +429 +00:31:13,650 --> 00:31:22,350 +Inability to use iron يعني الخلايا ما بتقدر تستخدم + +430 +00:31:22,350 --> 00:31:26,430 +الـ Iron لتصنيع الـ Hemoglobin وكمان بتحس .. يعني + +431 +00:31:26,430 --> 00:31:32,410 +بيصير في response للـ Erythropoietin أقل طبعاً يعني + +432 +00:31:32,410 --> 00:31:36,230 +سبب شائع من أسباب الـ Anemia طيب، الحالات المرضية + +433 +00:31:36,230 --> 00:31:39,790 +اللي بشوف فيها Anemia زي Rheumatoid Arthritis + +434 +00:31:40,440 --> 00:31:44,540 +Chronic Renal Disease Thyroid Disease Malignancies + +435 +00:31:44,540 --> 00:31:49,200 +Tuberculosis Chronic Fungal Infection هذه حالات + +436 +00:31:49,200 --> 00:31:54,600 +مرضية شائعة في حدوث أنيميا Anemia of chronic + +437 +00:31:54,600 --> 00:31:57,960 +disease pathogenesis إيش اللي بيصير في الانيميا of + +438 +00:31:57,960 --> 00:32:02,220 +chronic disease؟ الانيميا of chronic disease عادة + +439 +00:32:02,220 --> 00:32:06,000 +يعني ممكن يصير فيها inflammation الinflammation + +440 +00:32:06,000 --> 00:32:08,940 +بصاحب مجموعة من خلايا المناعة بما فيها الـ + +441 +00:32:08,940 --> 00:32:13,480 +Neutrophilلـ Neutrophil حبيباتها فيها مادة اسمها + +442 +00:32:13,480 --> 00:32:18,820 +الـ Lactoferrin تمام؟ الـ Lactoferrin هذا بيشبه أو + +443 +00:32:18,820 --> 00:32:23,280 +بينافس لـ Transferrin في عمله فبيروح و هو مرتبط + +444 +00:32:23,280 --> 00:32:27,200 +بالحديد و موديه لـ Macrophage بتاعة liver cell + +445 +00:32:27,200 --> 00:32:31,940 +بالتالي الجسم مش هيقدر يستفيد من الحديد اللي مرتبط + +446 +00:32:31,940 --> 00:32:35,740 +بالـ Lactoferrin نشوف Lactoferrin is an iron + +447 +00:32:35,740 --> 00:32:42,470 +binding protein in the granules of neutrophils it is + +448 +00:32:42,470 --> 00:32:46,230 +affinity for iron is greater than transferrin يعني + +449 +00:32:46,230 --> 00:32:49,490 +بيحب يرتبط بالiron أكتر مما بيفعل transferrin + +450 +00:32:49,490 --> 00:32:53,890 +during infection or inflammation neutrophils + +451 +00:32:53,890 --> 00:32:56,510 +lactoferrin is released into plasma and hunts + +452 +00:32:56,510 --> 00:33:00,350 +available iron بروح هو مقتنظ ال iron الموجود ماسك + +453 +00:33:00,350 --> 00:33:04,590 +فيه؟ binds to macrophages هيرتبط مع ال macrophages + +454 +00:33:04,590 --> 00:33:09,820 +and liver cellsوبالتالي ليش؟ لأنه فيها receptor + +455 +00:33:09,820 --> 00:33:13,240 +لـLactoferrin فبالتالي احنا ما استفدنا من الحديد + +456 +00:33:13,240 --> 00:33:17,880 +وهذا طبعا من الأسباب الشائعة لحدوث أنيميا في هذا + +457 +00:33:17,880 --> 00:33:20,960 +السبب، في سبب تاني أنه في الـinflammatory diseases + +458 +00:33:20,960 --> 00:33:23,620 +وفي الأمراض هذه بشكل عام تطلع الـcytokines + +459 +00:33:23,620 --> 00:33:28,260 +الـcytokines هذه بتنتج من الـmacrophages والخلايا + +460 +00:33:28,260 --> 00:33:33,940 +المناعة هذه عادة بتأثر على الـerythropoiesis يعني + +461 +00:33:33,940 --> 00:33:39,440 +بتعملفي الـ Early Stage منها الـ Lab Finding نيجي + +462 +00:33:39,440 --> 00:33:42,300 +للـ Lab Diagnosis في الـ Early Stage بلاقي + +463 +00:33:42,300 --> 00:33:45,560 +الانيميا normocytic-normochromic بعدين بتبدأ تتطور + +464 +00:33:45,560 --> 00:33:50,140 +لـhypochromic microcytic بلاقي leukocytosis لأن وضع + +465 +00:33:50,140 --> 00:33:53,280 +inflammation abundant storage of iron in + +466 +00:33:53,280 --> 00:33:57,280 +macrophages يعني في iron كتير ليش؟ لأن مافيش + +467 +00:33:57,280 --> 00:33:59,280 +استخدام جيد للـ iron diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..44941ae51ff7383b0dc490726d3cafd33f8d77fd --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM_postprocess.srt @@ -0,0 +1,1868 @@ +1 +00:00:01,690 --> 00:00:06,950 +الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبابتتقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +التلاتة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش أني أحفظ إيش تعريف الانيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش ال pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط النتائج هذه مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مساحبة لهذا ال result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,790 +على فحوصات عشان أتأكد من results معينة هذا الكلام + +20 +00:01:32,790 --> 00:01:36,810 +بإذن الله كله راح نناقشه مع بعض شويه شويه أول حاجة + +21 +00:01:36,810 --> 00:01:37,710 +هنشرحه بعد + +22 +00:01:53,700 --> 00:01:58,300 +الطريقة الأولى أو المعيار الأول لتصنيف الأنيميا + +23 +00:01:58,300 --> 00:02:02,800 +اللى هو الـ morphology للخلايا تم تصنيف الخلايا + +24 +00:02:02,800 --> 00:02:08,680 +حسب الـ MCV إلى تلت مجموعات Microcytic، + +25 +00:02:08,680 --> 00:02:13,220 +Normocytic، Macrocytic هذا التصنيف اللى إحنا هنمشي + +26 +00:02:13,220 --> 00:02:18,460 +عليه المعيار التانى في التصنيف كان الـ + +27 +00:02:18,460 --> 00:02:22,180 +Pathophysiology حسب الميكانزم أو قليل حدوث المرض + +28 +00:02:22,180 --> 00:02:27,080 +أو سبب المرضطبعاً أول حاجة اللي هو Embared + +29 +00:02:27,080 --> 00:02:30,860 +Erythrocyte Formation أنه في خلل في تصنيع الـ + +30 +00:02:30,860 --> 00:02:38,800 +Erythrocyte قد يكون هذا الخلل بسبب Primary Problem + +31 +00:02:38,800 --> 00:02:42,060 +في البون مارو يعني مشكلة أساسية في البون مارو زي + +32 +00:02:42,060 --> 00:02:45,420 +حالات الأبلاستيك أنيميا يعني خلل في البون مارو ما + +33 +00:02:45,420 --> 00:02:49,790 +بيقدر يصنع خلايا بشكل كافيأو خلال في تصنيع .. في + +34 +00:02:49,790 --> 00:02:53,470 +كمية .. يعني قدرته على تصنيع الـ Hemoglobin لأنه + +35 +00:02:53,470 --> 00:02:57,410 +في مثلا نقص حديد زي Iron Deficiency Anemia زي + +36 +00:02:57,410 --> 00:02:59,450 +Sidroblastic Anemia اللي بيبقى فيها خلال في + +37 +00:02:59,450 --> 00:03:03,410 +البروتوبرفيرين يعني أمثلة تانية الأنيميا أو الـ + +38 +00:03:03,410 --> 00:03:07,190 +Chronic Disease Megaloplastic Anemia إذا هنا في كل + +39 +00:03:07,190 --> 00:03:11,050 +هذه الحالات تشترك في شغلة إنه في خلال في الـ + +40 +00:03:11,050 --> 00:03:13,890 +Formation للـ RBCs يعني الـ RBCs كميتها هتكون + +41 +00:03:13,890 --> 00:03:17,860 +قليلة في الحالات هذه بشكل عامRBC قليلة + +42 +00:03:17,860 --> 00:03:22,060 +وReticulocyte قليلة هنا الـ «بون مارو» ما بيقدرش + +43 +00:03:22,060 --> 00:03:25,140 +يستجيب مع المرض يعني حتى لو كان فيه أنيميا البون + +44 +00:03:25,140 --> 00:03:28,220 +مارو ما بيقدر يصنع لأنه فيه نقص في العناصر + +45 +00:03:28,220 --> 00:03:31,760 +الأساسية اللي لازمة للتصنيع فقد ما يكون فيه نقص مش + +46 +00:03:31,760 --> 00:03:35,840 +هيقدر يعودها مهما اجتهد و مهما اشتغل مش هيقدر لأنه + +47 +00:03:35,840 --> 00:03:38,340 +إلا إذا إحنا أعطينا يعني مثلا فيه نقص حديد بنعطي + +48 +00:03:38,340 --> 00:03:42,300 +حديد بتشط البون مارو تمام؟ فيه نقص مثلا + +49 +00:03:45,920 --> 00:03:49,700 +الـ group التانية في هذه ال category اللي هي + +50 +00:03:49,700 --> 00:03:53,240 +increased blood loss إنه فيه فقد للـ blood قد يكون + +51 +00:03:53,240 --> 00:03:57,100 +بسبب bleeding acute or chronic عادة ال + +52 +00:03:57,100 --> 00:04:01,260 +reticulocyte هنا بتكون عالية لأنه مافي خلل في + +53 +00:04:01,260 --> 00:04:05,960 +البومارو و عنده القدرة إنه يعوض أي نزف أو أي فقد + +54 +00:04:05,960 --> 00:04:09,880 +من ال blood فبنلاقي ال reticulocyte عاليةطبعاً + +55 +00:04:09,880 --> 00:04:14,700 +إمتى بتصير هذه إذا كانت كمية إمتى بتصير الانيميا + +56 +00:04:14,700 --> 00:04:19,580 +صح البولمارو بيشطل لكن إذا فاق أو زاد كمية الفاقد + +57 +00:04:19,580 --> 00:04:22,980 +عن قدرة البولمارو على إنه يعودها فبيختلي الbalance + +58 +00:04:22,980 --> 00:04:27,140 +ما بين الفاقد وما بين الجديد أو المتكون أو المتصنع + +59 +00:04:27,140 --> 00:04:31,820 +الجديد فبالتالي بينشأ عندنا نوع من الانيمياالنوع + +60 +00:04:31,820 --> 00:04:34,400 +التالت أو المجموعة التالتة اللي هي increase + +61 +00:04:34,400 --> 00:04:38,080 +destruction of RBCs ده كتير اللي هي بنسميها احنا + +62 +00:04:38,080 --> 00:04:41,680 +hemolytic anemia هنا برضه ال reticulocyte count + +63 +00:04:41,680 --> 00:04:48,460 +بيكون عالي ونفس الشيء نيجي للتصنيف التانية اللي هي + +64 +00:04:48,460 --> 00:04:52,860 +حسب ال morphology حسب ال morphology في عندنا + +65 +00:04:52,860 --> 00:04:57,800 +normocytic normochromic anemia بداية طبعا قلنا + +66 +00:04:57,800 --> 00:05:03,850 +normocyticMicro-Cytic وMacro-Cytic ناخد أولا الـ + +67 +00:05:03,850 --> 00:05:08,410 +Normocytic Normocytic نورمو كروميك أنيميا هنا يعني + +68 +00:05:08,410 --> 00:05:13,590 +مافي خلل في الـ RBCs يعني الـ RBCs مافيش فيها + +69 +00:05:13,590 --> 00:05:16,430 +مشكلة خالص لا فيها نقص حديد ولا في خلل في حجمها + +70 +00:05:16,430 --> 00:05:21,570 +ولا في خلل في تصنيعها بس فيه بطء في عمليةفي خلال + +71 +00:05:21,570 --> 00:05:25,790 +معين ما أثر على الخلية وعلى وظيفتها لكن صار بطء في + +72 +00:05:25,790 --> 00:05:29,210 +تصنيع هذه الخلية في مشكلة في تصنيعها بس مش في + +73 +00:05:29,210 --> 00:05:32,670 +مكوناتها وفي قدرتها على العمل تمام فهذه الخلية + +74 +00:05:32,670 --> 00:05:37,150 +بتكون طبيعية normocytic محتواها من ال hemoglobin + +75 +00:05:37,150 --> 00:05:43,890 +طبيعي تمام لكن في مشكلة زي مثلا blood loss صار فقد + +76 +00:05:43,890 --> 00:05:47,310 +للدم الخلايا ما بتأثر شكلها ولا بتأثر ال + +77 +00:05:47,310 --> 00:05:51,110 +hemoglobin اللي فيها لكن بتأثر عددها تمامHemolytic + +78 +00:05:51,110 --> 00:05:54,030 +Anemia أبلاستيك أنيميا أبلاستيك أنيميا الخلايا + +79 +00:05:54,030 --> 00:05:57,990 +تتصنع خلايا كويسة لكن المشكلة إنه ما بتتصنع بالعدد + +80 +00:05:57,990 --> 00:06:00,990 +الكافي المناطق اللي بتشتغل في الـ bone marrow مش + +81 +00:06:00,990 --> 00:06:06,150 +كتيرة المناطق النشطة اللي بتصنع خلايا في حالات الـ + +82 +00:06:06,150 --> 00:06:08,730 +Chronic Diseases برضه في حالات الـ Renal + +83 +00:06:08,730 --> 00:06:09,490 +Insufficiency + +84 +00:06:15,800 --> 00:06:18,620 +الـ Renal Insufficiency اللي حكيناها طوي طبعاً + +85 +00:06:18,620 --> 00:06:22,220 +بيصير خلل في الـ Erythrobiotin ما بتطلعش بشكل كافي + +86 +00:06:22,220 --> 00:06:25,420 +فبالتالي ما بيصيرش stimulation للـ bone marrow + +87 +00:06:25,420 --> 00:06:29,000 +بشكل كافي وبالتالي ما بيطلعش خلايا كثير عشان ما + +88 +00:06:29,000 --> 00:06:34,440 +أرجع للشريحة هذه تمام نيجي للنوع التاني Microcytic + +89 +00:06:34,440 --> 00:06:38,060 +وعادة ال microcytic hypochromic بيكون كل ال blood + +90 +00:06:38,060 --> 00:06:41,880 +indices قليلة ال MCV له حجم الخلية قليل محتوى ال + +91 +00:06:41,880 --> 00:06:46,880 +Hemoglobin MCH و MCHC برضه قليلهذه مجموعة دايمًا + +92 +00:06:46,880 --> 00:06:49,940 +بنقول اللي هي بتشمل الـ Iron deficiency anemia + +93 +00:06:49,940 --> 00:06:53,060 +سيدرو بلاستيك أنيميا حالات الـ Lead poisoning + +94 +00:06:53,060 --> 00:06:59,120 +حالات الثلاثيميا حالات الـ Chronic diseases نيجي + +95 +00:06:59,120 --> 00:07:02,960 +للنوع التالت اللي هو Macrocytic Normochromate + +96 +00:07:02,960 --> 00:07:09,640 +خلاية كبيرة في الحجم MCV لها عالي والـ MCH والـ + +97 +00:07:09,640 --> 00:07:13,760 +MCHCممكن تكون Normal لأن محتوى الـ Hemoglobin + +98 +00:07:13,760 --> 00:07:17,340 +يتناسب بحجم الخلية في حالات الـ megaloplastic + +99 +00:07:17,340 --> 00:07:21,840 +anemia في حالات liver diseaseفي حالات بعد الـ + +100 +00:07:21,840 --> 00:07:25,560 +splenectomy في حالات الـ hypothyroidism في حالات + +101 +00:07:25,560 --> 00:07:28,340 +stress erythropoiesis يعني اللي بيقول مرة بيشتغل + +102 +00:07:28,340 --> 00:07:31,960 +تحت stress فبالتالي بيطلع خلايا لسه مش mature + +103 +00:07:31,960 --> 00:07:34,760 +كفاية اللي هي الـ reticulocyte اللي حكينا عنها + +104 +00:07:34,760 --> 00:07:39,180 +بتطلع بعدد كبير وطبعاً هذه أكبر شوية من الـ RBCs + +105 +00:07:39,180 --> 00:07:43,600 +العادية فبالتالي بالمجمل بتزود الـ MCV بتاع الـ + +106 +00:07:43,600 --> 00:07:50,750 +blood بتاع الـ RBCsهنا تصنيفة الخلايا حسب الـ + +107 +00:07:50,750 --> 00:07:55,710 +Morphology في عندي ثلاث صور من ثلاث أفلام واحد + +108 +00:07:55,710 --> 00:08:01,210 +فيهم Normal طبعا إذا فكرين قلنا بنقيس الحجم بنواة + +109 +00:08:01,210 --> 00:08:06,150 +الـ Lymphocyte لأنه يعني بدي حاجة Standard أقيس + +110 +00:08:06,150 --> 00:08:09,790 +عليها فبعتبر نواة الـ Lymphocyte Standard لو أجينا + +111 +00:08:09,790 --> 00:08:13,980 +هنا هنلاقي الفيلم هذا «Norma 6» «Norma Comics»هنا + +112 +00:08:13,980 --> 00:08:17,980 +هنلاقي الخلايا الصغيرة Microcytic وبرضه كمية الـ + +113 +00:08:17,980 --> 00:08:21,120 +Hemoglobin فيها قليلة طبعا إذا كنتوا فاكرين كمية + +114 +00:08:21,120 --> 00:08:24,960 +الـ Hemoglobin لازم أو المنطقة الفاضية عفوا ما + +115 +00:08:24,960 --> 00:08:29,220 +تزيدش عن طولة الخلية زي هات لكن هنا المنطقة + +116 +00:08:29,220 --> 00:08:32,240 +الفاضية زادت عن طولة الخلية فبسميها Hypochromic + +117 +00:08:32,240 --> 00:08:36,880 +هنا Microcytic Normochromic Microcytic لأنه زي ما + +118 +00:08:36,880 --> 00:08:40,920 +أنتوا شايفين الخلايا كبيرة مقارنة بنواة الـ + +119 +00:08:40,920 --> 00:08:49,610 +lymphocyte معظمها خلاياMacrocytic تمام هيجي في أول + +120 +00:08:49,610 --> 00:08:53,870 +نوع Microcytic Hypochromic AnemiaMicrocytic + +121 +00:08:53,870 --> 00:08:57,770 +Hypochromic Anemia التصنيفات اللي حكيناهم طوي + +122 +00:08:57,770 --> 00:09:02,050 +هنبلش ناخدهم بالتفصيل و هيهمني أنا أكتر حاجة الـ + +123 +00:09:02,050 --> 00:09:05,470 +differential diagnosis لإلهم كيف بميزهم عن بعض + +124 +00:09:08,810 --> 00:09:13,730 +أول حاجة بتتميز هذه يعني في .. في لها صفات هتلاقي + +125 +00:09:13,730 --> 00:09:18,410 +إن الـ RBCs صغيرة كلها يعني ال .. ال .. ال .. طبعا + +126 +00:09:18,410 --> 00:09:23,130 +Microcytic هيكون حجمها صغيرة المنطقة الوسطى اللي + +127 +00:09:23,130 --> 00:09:26,270 +هي الـ Central Palar Area هتلاقيها كبيرة لأنها + +128 +00:09:26,270 --> 00:09:31,530 +Microcytic Hypochromic Cells هذه الخلايا أو هذه + +129 +00:09:31,530 --> 00:09:37,150 +الحالات المرضية بتشمل Iron Deficiency Anemia + +130 +00:09:37,150 --> 00:09:41,420 +تلسيمياAnemia of Chronic Disease سيدرو بلاستيك + +131 +00:09:41,420 --> 00:09:45,180 +أنيميا led poisoning هذه صورة blood film زي ما + +132 +00:09:45,180 --> 00:09:49,020 +انتوا شايفين الخلايا الميتهيموجلبيين فيها قليلة + +133 +00:09:49,020 --> 00:09:54,020 +جدا بالاضافة لأن حجم الخلايا برضه صغير مقارنة + +134 +00:09:54,020 --> 00:10:00,320 +بنواة الينفوسايت الآن + +135 +00:10:00,320 --> 00:10:03,920 +بشكل عام بالنسبة لـMicrostatic Hypochromic Anemia + +136 +00:10:04,750 --> 00:10:07,950 +طبعا احنا عارفين ان الـ Hemoglobin بتكون من Hem + +137 +00:10:07,950 --> 00:10:13,410 +-Andoglobin تمام؟ Hem-Andoglobin قد يكون الخلل في + +138 +00:10:13,410 --> 00:10:18,590 +تصنيع الـ Hem نفسه الـ Hem مكون من Protoporphyrin + +139 +00:10:18,590 --> 00:10:24,590 +رنج 4 مع حديد صح؟ إذا صار الـ defect أو النقص في + +140 +00:10:24,590 --> 00:10:29,530 +كمية الحديدهتنتج عندي iron deficiency أنميا + +141 +00:10:29,530 --> 00:10:34,030 +وأحياناً برضه بتكون مصاحبة لـ chronic inflammation + +142 +00:10:34,030 --> 00:10:40,650 +أو أنميا of a chronic disease طبعاً لو صار في خلل + +143 +00:10:40,650 --> 00:10:46,110 +في تصنيع البروتو بورفيرين وتكونه برضه مش هيتكون + +144 +00:10:46,110 --> 00:10:50,350 +الهيم بشكل كافي فبالتالي بتنشأ عندي أو تتكون عندي + +145 +00:10:50,350 --> 00:10:53,940 +الـ cedroplastic أنميابينما لو صار الخلل في + +146 +00:10:53,940 --> 00:10:57,000 +الغلوبين الـChan Alpha أو Beta تطلع عندى + +147 +00:10:57,000 --> 00:11:03,720 +الثلاثيمية طبعا والأنواع هذه كلهاتها تتميز بأنها + +148 +00:11:03,720 --> 00:11:07,280 +Micro City Hypoxia هنا بنحكي عن الأسباب يعني إما + +149 +00:11:07,280 --> 00:11:10,820 +خلل في تصنيع الهيم أو الغلوبين الهيم قد يكون سببه + +150 +00:11:10,820 --> 00:11:15,260 +مشكلة بالـIron أو مشكلة بالبروتوبرفرين كل واحدة + +151 +00:11:15,260 --> 00:11:17,720 +بتطلع عندى نوع مختلف من الأنميا + +152 +00:11:20,430 --> 00:11:24,810 +هنا لو تخيلنا هذا Normal Plastic Maturation هذا + +153 +00:11:24,810 --> 00:11:29,450 +الحجم الطبيعي للخلايا خلال الـ Maturation لكن الـ + +154 +00:11:29,450 --> 00:11:32,670 +Microcytic Anemia هتبقى الخلايا من الأساس هتبقى + +155 +00:11:32,670 --> 00:11:36,410 +صغيرة ويصير الـ differentiation وتطلع عندي بالآخر + +156 +00:11:36,410 --> 00:11:42,550 +mature erythrocyte توصف بأنها Microcytic Cell + +157 +00:11:42,550 --> 00:11:47,530 +دعونا نبدأ بالـ Iron Deficiency Anemia لأن هي أكثر + +158 +00:11:47,530 --> 00:11:51,700 +أنواع الأنيميا انتشراالـ Iron deficiency anemia + +159 +00:11:51,700 --> 00:11:55,220 +تنتج + +160 +00:11:55,220 --> 00:12:01,800 +من نقص الحديد في الجسم طبعاً هينعكس على الـ Serum + +161 +00:12:01,800 --> 00:12:07,460 +Iron هنلاقي فيه نقص طبعاً نقص الحديد هيؤدي لخلل في + +162 +00:12:07,460 --> 00:12:11,540 +تصنيع الهيم وبالتالي نقص في الـ Hemoglobin وهذا + +163 +00:12:11,540 --> 00:12:16,300 +بينتج عنه Iron deficiency anemia تشكل أكتر من + +164 +00:12:16,300 --> 00:12:17,040 +نصحلات + +165 +00:12:19,650 --> 00:12:22,610 +السبب الأول والرئيسي اللي هو nutritional + +166 +00:12:22,610 --> 00:12:26,170 +deficiency طبيعة الأكل، الاهتمام بالخضار، + +167 +00:12:26,170 --> 00:12:28,770 +بالفواكه، باللحوم، بالعناصر الغذائية، الهمة + +168 +00:12:28,770 --> 00:12:33,130 +بالطعام طيب، في ناس تيجي بتقولك أنا أكل كويس + +169 +00:12:33,130 --> 00:12:37,590 +ومتوازن لكن هي بتلاقي الدم عندها الـHemoglobin + +170 +00:12:37,590 --> 00:12:41,930 +عندها ما بيرتفع ممكن يكون سببها إن في عندهم + +171 +00:12:41,930 --> 00:12:46,140 +malabsorption، في خلل في امتصاص الحديدهذا يعني + +172 +00:12:46,140 --> 00:12:50,640 +ممكن يكون خلل طبيعي يعني أو يعني مخلوق فيه عيب + +173 +00:12:50,640 --> 00:12:54,560 +خلقي إنه في عندها الحديد ما بينتصب الشكل الجيد أو + +174 +00:12:54,560 --> 00:12:59,660 +نتيجة عادة غذائية سيئة يعني مثلا إحنا عارفين إنه + +175 +00:12:59,660 --> 00:13:03,100 +بالـ calcium والحديد الـ calcium بيعكس على الحديد + +176 +00:13:03,100 --> 00:13:07,380 +صح أو إنه مثلا بعد لو الواجبات اللي فيها الحديد + +177 +00:13:07,380 --> 00:13:11,760 +بتاخد شاي الشاي بيأثر عن تصاص الحديد فيعني هذه قصة + +178 +00:13:11,760 --> 00:13:16,180 +الـ absorptioninefficient transport storage or + +179 +00:13:16,180 --> 00:13:19,080 +utilization of iron يعني فيه مشكلة في نقل الحديد + +180 +00:13:19,080 --> 00:13:22,380 +وفي تخزينه وفي الـ height تبعه واستهلاكه في الجسم + +181 +00:13:22,380 --> 00:13:29,080 +increased need يعني في حاجة زائدة أو فائدة للحديد + +182 +00:13:29,080 --> 00:13:34,080 +في الجسم chronic blood loss الفاقد بزيادة زي ما + +183 +00:13:34,080 --> 00:13:39,740 +يكون فيه نزيف أو ulcer أو heavy menstruation طبعا + +184 +00:13:39,740 --> 00:13:43,930 +عارفين مصادر الحديد قد تكون حيوانية وقد تكوننباتية + +185 +00:13:43,930 --> 00:13:49,950 +بيبين + +186 +00:13:49,950 --> 00:13:54,670 +ايش الاحتياج اليومي للحديد حسب الفئة العمرية وحسب + +187 +00:13:54,670 --> 00:14:00,510 +التوزيع ال iron في الجسم هذه كويسة يعني عندنا ال + +188 +00:14:00,510 --> 00:14:04,830 +iron موجود 65% بيكون منه في الحديد في ال + +189 +00:14:04,830 --> 00:14:09,460 +hemoglobin عفوافي الريتين و الهيموسيدرين كمخزون + +190 +00:14:09,460 --> 00:14:13,180 +بنلاقي تلاتين تقريبا في المية ال myoglobin بنلاقي + +191 +00:14:13,180 --> 00:14:16,200 +فيه تلاتة و نصف في المية ال hem enzymes تقريبا نصف + +192 +00:14:16,200 --> 00:14:20,200 +في المية هنا point one transferring bound iron + +193 +00:14:20,200 --> 00:14:25,720 +بتلاقي كمية من الحديد مرتبطة فيه داخل ال iron + +194 +00:14:25,720 --> 00:14:31,020 +deficiency anemia طبعا لو صار فيه فقد لل iron أو + +195 +00:14:34,480 --> 00:14:38,040 +يعني إنه إحنا محتاجين حديد بزيادة في الجسم زيادة + +196 +00:14:38,040 --> 00:14:42,580 +التصنيع أو هيك إشي طبعاً هيصير استهلاك بزيادة + +197 +00:14:42,580 --> 00:14:46,780 +للحديد وإذا كان الإنسان مابياخدش الكمية الكافية عن + +198 +00:14:46,780 --> 00:14:50,540 +طريق الغذاء هتبدأ تتطور عنده الـ Iron deficiency + +199 +00:14:50,540 --> 00:14:56,680 +anemiaأول حاجة مرحلة انه يعني الـ Peripheral blood + +200 +00:14:56,680 --> 00:15:00,380 +والـ RBCs ما بتتغير وحتى الـ Serum ما بتتغير فيه + +201 +00:15:00,380 --> 00:15:03,860 +منسوب الحديد بيبدأ ينقص وين في ال stars احنا + +202 +00:15:03,860 --> 00:15:06,960 +عارفين انه ال stars بتاعة الحديد في الأنسجة + +203 +00:15:06,960 --> 00:15:10,960 +الفيريتين فبنلاقي و الفيريتين بيكون نسبة بسيطة منه + +204 +00:15:10,960 --> 00:15:15,240 +في ال bloodبسيطة جدا يعني وفي توازن مع لف الأنسجة + +205 +00:15:15,240 --> 00:15:18,780 +فلو نقصة طلف السيرام معنى الكلام أنه صار فيه نقص + +206 +00:15:18,780 --> 00:15:23,100 +في الحديد المخزن يعني أول حاجة بيبدأ الحديد من وين + +207 +00:15:23,100 --> 00:15:27,620 +يسحب يسحب من المخزون من الفرتين وهذا بينعكس على + +208 +00:15:27,620 --> 00:15:32,800 +الفرتين الموجود بالسيرام يعني أول مرحلة أن السيرام + +209 +00:15:32,800 --> 00:15:36,720 +Iron بيكون طبيعي بياخد Iron من المخزنالـ Total + +210 +00:15:36,720 --> 00:15:40,540 +Iron Binding Capacity طبيعية مافيش أنيميا، مافيش + +211 +00:15:40,540 --> 00:15:44,100 +أي أعراض الـ RBCs Normal نورموستيك، نورموكروميك + +212 +00:15:44,100 --> 00:15:48,520 +لكن وين بتبدأ تبين المشكلة؟ في الفيريتين بيكون الـ + +213 +00:15:48,520 --> 00:15:52,400 +Serum في الفيريتين قليل لأن هنا بلش الحديد ينسحب + +214 +00:15:52,400 --> 00:15:56,720 +من الـ Iron Stars بيتبلش ينسحب من المخازن فبيبدأ + +215 +00:15:56,720 --> 00:16:01,680 +ينقص الفيريتين المرحلة التانية بيبدأ ينقص الـ + +216 +00:16:01,680 --> 00:16:05,730 +Serum Iron بس لسه الـ RBCs ما اتغيرتسيرام ايرن + +217 +00:16:05,730 --> 00:16:09,970 +بنقص الـ Total Iron Binding Capacity بتنقص وبرضه + +218 +00:16:09,970 --> 00:16:15,530 +خدوبة لكم الفرتين من الأساس هو أصلا ناقص لكن ما + +219 +00:16:15,530 --> 00:16:19,330 +بيكون لسه فيه أنيميا ال RBC's بتكون طبيعية المرحلة + +220 +00:16:19,330 --> 00:16:25,730 +التالتةإنه يعني خلاص انسحبت المخازن والحديد اللي + +221 +00:16:25,730 --> 00:16:29,750 +بيتاخد ما بيكفي إنه نصنع Hemoglobin كويس فبنعدّي + +222 +00:16:29,750 --> 00:16:34,010 +في المرحلة التالتة اللي هي مرحلة الأنيميا الحقيقية + +223 +00:16:34,010 --> 00:16:38,010 +إنه الـ Iron stores فضيت الحديد نزل في الـ Serum + +224 +00:16:38,010 --> 00:16:41,150 +فبالتالي بتبدأ الأنيميا تظهر اللي هي Microcytic + +225 +00:16:41,150 --> 00:16:45,150 +Hypochromic Anemia أو Microcytic HypochromicRed + +226 +00:16:45,150 --> 00:16:49,290 +cells وبتنشأ حالة Iron deficiency anemia يعني مش + +227 +00:16:49,290 --> 00:16:53,630 +من أول ما بيبدأ ينقص ال iron بنبدأ احنا لل + +228 +00:16:53,630 --> 00:16:57,970 +symptoms بتاعة ال iron deficiency anemia طبعا فينا + +229 +00:16:57,970 --> 00:17:02,110 +fatigue, dizziness, headache فينا برضه بعض ال + +230 +00:17:02,110 --> 00:17:05,030 +signs المميزة لل iron deficiency anemia زي ال + +231 +00:17:05,030 --> 00:17:12,670 +smooth tongue زي ال stomatitis اللي هي في الأظافر + +232 +00:17:12,670 --> 00:17:19,950 +وتشققطبعاً هذا من علامات الـ Iron نيجي لل lab + +233 +00:17:19,950 --> 00:17:24,190 +diagnosis of iron deficiency أنيميا فحصات خاصة + +234 +00:17:24,190 --> 00:17:28,310 +بالحديد فحصات خاصة بالحديد هذه ممكن نستخدمها عشان + +235 +00:17:28,310 --> 00:17:32,090 +نعمل differential diagnosis لل microcytic + +236 +00:17:32,090 --> 00:17:34,890 +hypochronic أنيميا لأنواعها المختلفة الميزها عن + +237 +00:17:34,890 --> 00:17:38,670 +بعض أو إذا كان في iron overload إذا كان في زيادة + +238 +00:17:38,670 --> 00:17:42,330 +في ال iron برضه ممكن نقيس ال ironطيب قبل ما نبدأ + +239 +00:17:42,330 --> 00:17:45,810 +نحكي في الـ Iron Test لنفهم شغلة مهمة كتير أنه أنا + +240 +00:17:45,810 --> 00:17:51,630 +اللي بقيسه Iron مرتبط بحاجة اسمها Transferrin إيش + +241 +00:17:51,630 --> 00:17:54,770 +هو الـ Transferrin؟ هو عبارة عن بروتين ناقل + +242 +00:17:54,770 --> 00:17:59,470 +للحديد، تمام؟ عادة للـ Transferrin هذا بلاقي منه + +243 +00:17:59,470 --> 00:18:06,050 +33% مرتبط بالـ Iron والباقي بيكون مش مرتبط، كويس؟ + +244 +00:18:06,050 --> 00:18:11,420 +طيب، فأنا عندي تحوصات بعملها الـ Serum Ironالـ + +245 +00:18:11,420 --> 00:18:15,900 +Serum Iron يا بنات هو فعليًا الـ Serum العفواني + +246 +00:18:15,900 --> 00:18:18,680 +الـ Iron المرتبط بالـ Transferring يعني أنا هي هذه + +247 +00:18:18,680 --> 00:18:24,600 +الـ 33% بدي أقدر قدش .. قدش هي تركزها تمام الـ + +248 +00:18:24,600 --> 00:18:30,320 +Total Iron Binding Capacity هذه بأقيص فيها قدش في + +249 +00:18:30,320 --> 00:18:34,860 +عندي حديد قادر يرتبط بـ Transferring بمعنى آخر قدش + +250 +00:18:34,860 --> 00:18:41,010 +في عندي Transferring Free كل مكان الحديد أقلتمام، + +251 +00:18:41,010 --> 00:18:44,490 +هيكون الـ Transferrin Free أكتر فهذه علاقتها عكسية + +252 +00:18:44,490 --> 00:18:51,490 +مع الـ Iron طيب، Serum Iron Level بدايتان قلتلكم + +253 +00:18:51,490 --> 00:18:54,690 +هو بنقيس من خلالها الـ Iron المرتبط بالـ + +254 +00:18:54,690 --> 00:18:59,530 +Transferrin طبعاً ما بقيس الـ Iron لـ Free، بقيس + +255 +00:18:59,530 --> 00:19:04,430 +المرتبط Total Iron Binding Capacity زي ما قلنا، هي + +256 +00:19:04,430 --> 00:19:07,700 +عبارة عن indirect measuredمن الـ amount of + +257 +00:19:07,700 --> 00:19:10,240 +transferin بروتين in the serum الترانسفيرين + +258 +00:19:10,240 --> 00:19:13,600 +الموجود اللي مش مرتبط اللي موجود بالـ serum طبعاً + +259 +00:19:13,600 --> 00:19:16,700 +و بديه زي ما قلنا هناك علاقة عكسية كل ما كان + +260 +00:19:16,700 --> 00:19:20,420 +الحديد أكتر كل ما كان الترانسفيرين الـ free أقل كل + +261 +00:19:20,420 --> 00:19:23,020 +ما كان الحديد قليل زي حالات الـ iron deficiency + +262 +00:19:23,020 --> 00:19:26,540 +أنيمية هتلاقي الترانسفيرين زاد فبالتالي هي + +263 +00:19:26,540 --> 00:19:29,340 +الترانسفيرين بيعبر عنها الـ total iron binding + +264 +00:19:29,340 --> 00:19:33,440 +capacity فبالتالي هيكون تناسب عكسي ما بين الـ TIPC + +265 +00:19:33,440 --> 00:19:37,840 +وما بين الـ iron في الجسمIf serum iron is + +266 +00:19:37,840 --> 00:19:40,440 +decreased, total iron binding capacity of + +267 +00:19:40,440 --> 00:19:43,940 +transferrin increase.Transferrin has more empty + +268 +00:19:43,940 --> 00:19:47,700 +space to carry iron يعني فيه فراغات أو أماكن فاضية + +269 +00:19:47,700 --> 00:19:53,920 +شاغرة من الـ iron نتيجة نقص الـ iron بالسيرام نيجي + +270 +00:19:53,920 --> 00:19:58,460 +للسيرام فريتين طبعا الفريتين هو بروتين بيتحكم في + +271 +00:19:58,460 --> 00:20:04,240 +تخزين الحديدالفرهتين هذا يعني موجود بشكل أساسي في + +272 +00:20:04,240 --> 00:20:07,700 +الأنسجة موجود كمية بسيطة منه في ال blood لكن + +273 +00:20:07,700 --> 00:20:11,460 +الكمية اللي في ال blood بتعكس عند صورة الموجود في + +274 +00:20:11,460 --> 00:20:16,240 +الأنسجةFound interest amount in plasma it is in + +275 +00:20:16,240 --> 00:20:19,080 +equilibrium with the body stars يعني فيه تناسب كل + +276 +00:20:19,080 --> 00:20:22,880 +ما كانت كميته كل ما قلت كميته في الـPlug أو في + +277 +00:20:22,880 --> 00:20:25,920 +الـSerum أو في الـPlasma معنى الكلام إنه نقص في + +278 +00:20:25,920 --> 00:20:29,960 +نقصة الـIron Stars أو نقص الحديد في مكازنه في + +279 +00:20:29,960 --> 00:20:33,740 +الانسجنVariation in the quantity of iron in the + +280 +00:20:33,740 --> 00:20:36,000 +storing environment is reflected by plasma + +281 +00:20:36,000 --> 00:20:38,460 +ferritin concentration نفس الكلام اللي قلناه يعني + +282 +00:20:38,460 --> 00:20:42,420 +لو نقص الحديد في المخزون الحديد في الأنسجة بنقص + +283 +00:20:42,420 --> 00:20:47,180 +الferritin اللي موجود في البلازمة كم تبقى نقص؟ في + +284 +00:20:47,180 --> 00:20:51,280 +مراحل مبكرة من ال iron deficiency أنميا و بزيد في + +285 +00:20:51,280 --> 00:20:56,460 +حالات الانميا أو ال chronic disease طبعا فينا هنا + +286 +00:20:56,460 --> 00:21:00,040 +ملاحظة بس بدنا ناخد بالنا منهابقولك في بعض حالات + +287 +00:21:00,040 --> 00:21:03,280 +الـ infection أو الـ inflammation سيرم في الـ + +288 +00:21:03,280 --> 00:21:08,900 +ريتين بزيد لأنه عبارة عن acute phase protein من + +289 +00:21:08,900 --> 00:21:11,780 +البروتينات اللي بتطلع في الـ acute phase + +290 +00:21:11,780 --> 00:21:17,830 +inflammation أو infectionطبعا هنا يعني هذه تعتبر + +291 +00:21:17,830 --> 00:21:21,310 +Indicator مش كتير صحيح أو الفيريتين يعتبر + +292 +00:21:21,310 --> 00:21:24,190 +Indicator مش كتير صحيح عن وضع الحديد في حالات ال + +293 +00:21:24,190 --> 00:21:26,790 +inflammation بس بدي أخد بالي لو في acute + +294 +00:21:26,790 --> 00:21:31,130 +inflammation أجل موضوع قياس الفيريتين شوية فلاش + +295 +00:21:31,130 --> 00:21:37,390 +يعطيني pause ابون مارو ايران يعني احنا خلصنا هيك + +296 +00:21:37,390 --> 00:21:41,740 +حكينا عن ال serum ironبنقيص المحتوى الحديد أو + +297 +00:21:41,740 --> 00:21:46,100 +دراسة الحديد الـ Iron Profile بنسميه بنقيص الـ + +298 +00:21:46,100 --> 00:21:49,320 +Iron بنقيص الـ Total Iron Binding Capacity اللي + +299 +00:21:49,320 --> 00:21:52,880 +بتعبر عن الترانسفيرين بنقيص الفيريتين خلصنا منهم + +300 +00:21:52,880 --> 00:21:56,120 +فلقيت الـ Bone Marrow Iron كيف بده أشوف الـ Bone + +301 +00:21:56,120 --> 00:22:00,160 +Marrow وضع الـ Iron فيه أول حاجة issue biopsy of + +302 +00:22:00,160 --> 00:22:04,380 +bone marrowممكن بالبروجياني بلوستين هذه صبغة خاصة + +303 +00:22:04,380 --> 00:22:08,780 +للحديد type of iron موجود في البونمارو هو + +304 +00:22:08,780 --> 00:22:13,300 +الهيموسيدرين يخزن في البونمارو على شكل هيموسيدرين + +305 +00:22:13,300 --> 00:22:20,860 +هنا صور هي هذه normal شايفين هذه صبغة البروجياني + +306 +00:22:20,860 --> 00:22:25,560 +بلو تصبغ مخزن الحديد الهيموسيدرين هنا مش موجود في + +307 +00:22:25,560 --> 00:22:27,980 +حالة ال iron deficiency مافيش عندى اللون الأزرق + +308 +00:22:27,980 --> 00:22:32,640 +خالص معناه الكلام ان في عندى أنمياIron deficiency + +309 +00:22:32,640 --> 00:22:38,660 +anemia طيب نيجي لل lab finding في الـ Iron + +310 +00:22:38,660 --> 00:22:45,520 +deficiency anemia law كل إشي law كل إشي law ما عدا + +311 +00:22:45,520 --> 00:22:49,600 +ال white pieces و ال platelets ال RBCs hemoglobin + +312 +00:22:49,600 --> 00:22:55,900 +hematocrit law ال MCV ال MCH ال MCHC برضه law ليش؟ + +313 +00:22:55,900 --> 00:22:59,780 +لأن حجم الخلايا صغير ومحتوها من الهمoglobin صغير + +314 +00:22:59,780 --> 00:23:04,620 +تمام؟يعني لو جينا لهذا الـ CPC الـ White PCs طبعا + +315 +00:23:04,620 --> 00:23:09,020 +الـ Platelets ما راح تتأثر الـ RPCs 2.9، + +316 +00:23:09,020 --> 00:23:16,400 +Hemoglobin 6.3، Hematocrit 24، MCV 69، MCH 1 يعني + +317 +00:23:16,400 --> 00:23:20,400 +كل الـ Parameters قليلة مع ده الـ Platelets و الـ + +318 +00:23:20,400 --> 00:23:27,160 +RPC و ال .. مع ده الـ Platelets و ال .. و ال White + +319 +00:23:27,160 --> 00:23:27,460 +PCs + +320 +00:23:32,520 --> 00:23:36,240 +الـ RBCs مورفولوجي لو احنا عملنا بلد فيلم بنلاقي + +321 +00:23:36,240 --> 00:23:40,100 +hypochromic microcytic cells بنلاقي anisocytosis + +322 +00:23:40,100 --> 00:23:44,020 +يعني التغير في أحجام الخلايا boiculocytosis ممكن + +323 +00:23:44,020 --> 00:23:47,100 +أشوف اللي هي الـ Pencil Cell خلية الـ Cigar Cell + +324 +00:23:47,100 --> 00:23:52,660 +خلية رفيعة كتير يعني زي الـ Electrocyte برضه ممكن + +325 +00:23:52,660 --> 00:23:58,160 +أشوف Target Cell طبعاً مابشوفش inclusion bodies في + +326 +00:23:58,160 --> 00:24:03,240 +الـ RBCs خالص Iron Parameters هلاقي الـ Ironلو الـ + +327 +00:24:03,240 --> 00:24:06,580 +Total Iron Binding Capacity عالي السيرام في + +328 +00:24:06,580 --> 00:24:12,320 +الريتين حلاقيه فليل هاي + +329 +00:24:12,320 --> 00:24:15,180 +عندنا blood film زي ما انتوا شايفين الخلايا كلها + +330 +00:24:15,180 --> 00:24:20,090 +تقريبا صغيرة هو احنا هنا مافيش عندناالانفوسايت + +331 +00:24:20,090 --> 00:24:23,970 +انقارن فيها لكن هو بقوللي ان الخلايا كلها صغيرة في + +332 +00:24:23,970 --> 00:24:26,910 +عندي الـEleptocyte اللي هي الـPencil Cell في عندي + +333 +00:24:26,910 --> 00:24:31,130 +الـOvalocyte هذه الـEleptocyte مش Ovalocyte هى هذه + +334 +00:24:31,130 --> 00:24:34,210 +الـOvalocyte فاكرين كيف بنفرق من الـOval و + +335 +00:24:34,210 --> 00:24:40,510 +الـElepto؟ الـElepto بتكون أرفع بحيث انه عرضها هذا + +336 +00:24:40,510 --> 00:24:45,930 +أقل من طولها أقل من ضعف طولها فهمتوا؟ عرضها أقل من + +337 +00:24:45,930 --> 00:24:51,300 +ضعف طولها بتكونالـ Leptocyte إذا كان عرضها أكتر من + +338 +00:24:51,300 --> 00:24:56,240 +ضعف طولها بتكون Ovalocyte وشايفين الـ Hypochromia + +339 +00:24:56,240 --> 00:24:58,920 +الواضحة في الخلايا إذن Anesocytosis and + +340 +00:24:58,920 --> 00:25:06,420 +Poikilocytosis مافيش inclusion bodies طيب + +341 +00:25:06,420 --> 00:25:11,240 +نيجي للـ Sidroblastic Anemia Sidroblastic Anemia + +342 +00:25:11,240 --> 00:25:14,180 +يمكن أنا نوحت في البداية في الـ Iron Deficiency + +343 +00:25:14,580 --> 00:25:19,160 +والـ Cedroplastic بتركوا التنتين في شغلة ان + +344 +00:25:19,160 --> 00:25:22,300 +التنتين في خلل في تصنيع الهيم وبالتالي الـ + +345 +00:25:22,300 --> 00:25:27,260 +Hemoglobin لكن الـ Iron deficiency الخلل في الحديد + +346 +00:25:27,260 --> 00:25:30,000 +الـ Cedroplastic في البروتوبرفيرين اللي بيكون + +347 +00:25:30,000 --> 00:25:33,880 +البروتوبرفيرين رينج بتاعة الهيم هي عبارة عن جروب + +348 +00:25:33,880 --> 00:25:37,700 +من الأنميا تتميز فيه defective protoperferin + +349 +00:25:37,700 --> 00:25:41,960 +synthesis طبعا هذا منتج عنه iron loading زيادة + +350 +00:25:41,960 --> 00:25:45,600 +للحديد الحديد مافيش فيه مشكلةلكن لأن الـ + +351 +00:25:45,600 --> 00:25:49,740 +Hemoglobin مش هيتصنع الحديد موجود، الـ Hemoglobin + +352 +00:25:49,740 --> 00:25:53,220 +مش هيتصنع فهيبدأ يتراكم الحديد ويزيد عكس الـ Iron + +353 +00:25:53,220 --> 00:25:56,460 +deficiency anemia تنتج عندنا Hypochromic anemia + +354 +00:25:56,460 --> 00:26:00,360 +نتيجة نقص تصنيع الـ Hemoglobin الـ blocks in + +355 +00:26:00,360 --> 00:26:03,920 +protoporphyrin synthesis lead to iron overload and + +356 +00:26:03,920 --> 00:26:06,860 +microcytic hypochromic anemia ملخص الـ + +357 +00:26:06,860 --> 00:26:07,540 +Acidroplastic + +358 +00:26:14,240 --> 00:26:18,300 +Cedrocite هي عبارة عن mature herbicides هذه في + +359 +00:26:18,300 --> 00:26:20,820 +الوضع الطبيعي أنا مابشوفهاش في الـ Peripheral + +360 +00:26:20,820 --> 00:26:27,720 +blood هي خلية فيها بقايا حديد granules متخزنة في + +361 +00:26:27,720 --> 00:26:31,020 +الـ mitochondria بتاعة الخلايا طبعا هذه أنا في + +362 +00:26:31,020 --> 00:26:34,340 +الوضع الطبيعي مابشوفها إذا كنتوا فاكرين لما حكينا + +363 +00:26:34,340 --> 00:26:37,840 +عن ال inclusion bodies حكينا فيه ترسبات حديد + +364 +00:26:37,840 --> 00:26:40,620 +أحيانا تظهر في الخلية في بعض الحالات المرضية + +365 +00:26:40,620 --> 00:26:44,770 +سميناها Pfeffenheimer bodiesالخلية اللي فيها + +366 +00:26:44,770 --> 00:26:48,550 +البابنهايمر بادرس هذه بسميها Sidrocyte وهذه مميزة + +367 +00:26:48,550 --> 00:26:54,150 +يعني لحالات Sidroblast كامية ليش؟ لأنه فيه زيادة + +368 +00:26:54,150 --> 00:26:58,510 +في الحديد Sidroblast هي عبارة عن Immature + +369 +00:26:58,510 --> 00:27:02,550 +nucleated RBCs in the bone marrow هيكون فيها كمية + +370 +00:27:02,550 --> 00:27:06,230 +من الحديد في الـCytoplasm هذه بتكون موجودة بشكل + +371 +00:27:06,230 --> 00:27:10,070 +طبيعي Sidroblast ليش؟ لأن الحديد طبيعي موجود في + +372 +00:27:10,070 --> 00:27:13,610 +الـbone marrow ومتخزنلكن إذا كنت بتكون Abnormal + +373 +00:27:13,610 --> 00:27:23,690 +شكل Ring Iron form a ring around the nucleus إذا + +374 +00:27:23,690 --> 00:27:27,910 +كان الحديد متخزن على شكل دائرة حوالين النواة هذه + +375 +00:27:27,910 --> 00:27:32,790 +تعتبر حالة مميزة لـCedroblastic Anemia وبسمي + +376 +00:27:32,790 --> 00:27:37,670 +الخلية في هذه الحالة Ring CedroblastRing + +377 +00:27:37,670 --> 00:27:40,410 +Sedroblast هنا Sedroblastic Anemia characterised + +378 +00:27:40,410 --> 00:27:43,370 +by the accumulation of iron in the mitochondria of + +379 +00:27:43,370 --> 00:27:46,670 +immature nucleated RBCs in the bone marrow على شكل + +380 +00:27:46,670 --> 00:27:51,590 +الـRing بسميها Ring Sedroblast وبتعتبر علامة مميزة + +381 +00:27:51,590 --> 00:27:53,730 +بعيد لـSedroblastic Anemia + +382 +00:27:56,460 --> 00:28:00,320 +طيب نيجي للـ Lab finding في الـ Sidroblastic + +383 +00:28:00,320 --> 00:28:04,720 +Anemia طبعا زي ما اتفقنا هيكون كل إشي قليل واطي + +384 +00:28:04,720 --> 00:28:08,040 +Microcytic Hypochromic Anemia الـ MCV الـ MCHC + +385 +00:28:08,040 --> 00:28:12,220 +الانيميا هتكون variable اللي هو reticulocyte count + +386 +00:28:12,220 --> 00:28:15,700 +لأن احنا اتفقنا هدول ال reticulocyte بيكون قليل + +387 +00:28:15,700 --> 00:28:19,420 +فيها ال iron deficiency و الحاجات اللي لها علاقة + +388 +00:28:19,420 --> 00:28:22,340 +بال nutritional مع ال Sidroblastic Anemia هتبتبت + +389 +00:28:22,340 --> 00:28:25,480 +تبقى reticulocyte قليلةاللي بيبقى فيه مشكلة في + +390 +00:28:25,480 --> 00:28:29,240 +تصنيع الـBlood نفسه الـHemoglobin والـRBCs طيب + +391 +00:28:29,240 --> 00:28:35,020 +RBCs Inclusions عادة ممكن أشوف بيزوفيليكستبلينج + +392 +00:28:35,020 --> 00:28:38,320 +أشهى الـBiophilic Stibling؟ هي بقايا ريبوزاما + +393 +00:28:38,320 --> 00:28:44,140 +الـRNA and ببنهاي مربادز اللي هي الـCedrocide ممكن + +394 +00:28:44,140 --> 00:28:49,300 +أشوف في بعض الأحيان Target Cells طيب بتتميز بإيش + +395 +00:28:49,300 --> 00:28:53,310 +هذه؟ نيجي لفحوصات الـSerumالـ Iron كيف هيكون؟ أكيد + +396 +00:28:53,310 --> 00:28:57,310 +هيكون عالي لأنه متراكم تمام؟ الـ Serum في الريتين + +397 +00:28:57,310 --> 00:29:00,290 +برضه عالي لكن الـ Total Iron Binding Capacity + +398 +00:29:00,290 --> 00:29:05,750 +هيكون Low ليش؟ لأن الـ Transferrin الموجود هيكون + +399 +00:29:05,750 --> 00:29:09,530 +مرتبط لأنه حديد كتير فبالتالي الـ Total Iron + +400 +00:29:09,530 --> 00:29:12,990 +Binding Capacity هي ببساطة قدرة الـ Transferrin + +401 +00:29:12,990 --> 00:29:17,590 +على ارتباط بالـ Ironطيب، decrease transferrin + +402 +00:29:17,590 --> 00:29:21,390 +synthesis occur in iron-overlaid states يعني هيكون + +403 +00:29:21,390 --> 00:29:28,170 +فيه برضه نقص في تصنيع الترانسفيرين وهذا بنعاكس في + +404 +00:29:28,170 --> 00:29:32,230 +الـ Total Iron Binding Capacity اللوه بون مارو + +405 +00:29:32,230 --> 00:29:35,150 +بشوف في الـ Ring Sidroblast ومرة تانية بقول + +406 +00:29:35,150 --> 00:29:37,950 +Hallmark of Sidroblastic Linia قلت لهم بجيبها + +407 +00:29:37,950 --> 00:29:39,190 +بالامتحان وما بتعرفوهاش + +408 +00:29:41,860 --> 00:29:46,600 +هنا عندنا شوية صور في عندى البابنهايمر body + +409 +00:29:46,600 --> 00:29:49,900 +بابنهايمر body زى ما انتوا شايفين عبارة عن زى + +410 +00:29:49,900 --> 00:29:53,740 +clusters بتكون في الخلية زى براد الحديد تجمعات من + +411 +00:29:53,740 --> 00:29:56,920 +الحديد هذا الـ cedroblast العادية انها شوف فيها + +412 +00:29:56,920 --> 00:30:00,920 +iron granules أما تزيد ال granules و تصير لها تجمع + +413 +00:30:00,920 --> 00:30:04,380 +حوالين النواء هذا بدل على انها cedroblastic anemia + +414 +00:30:04,380 --> 00:30:11,160 +هى عندى الصورة الحقيقية لها هى البابنهايمر bodyهي + +415 +00:30:11,160 --> 00:30:15,920 +الـ Cedroblast انه تجمع عادي للحديد حوالين الخلية + +416 +00:30:15,920 --> 00:30:19,460 +لكن لما يكون بهذا الشكل بقول هذه غالبا + +417 +00:30:19,460 --> 00:30:25,220 +Cedroblastic Anemia هاي عندنا مجموعة صور كمان هاي + +418 +00:30:25,220 --> 00:30:28,320 +هادي Mesophilic Stippling هادي Webbenheimer bodies + +419 +00:30:28,320 --> 00:30:34,000 +هادي برضه بس هنا varieties تانية بنات هنا + +420 +00:30:34,000 --> 00:30:36,600 +بالبروجياني blue stain علشان هيك ظهرت بهذا اللون + +421 +00:30:36,600 --> 00:30:43,620 +اللي هي ال Webbenheimer bodiesطيب البولمارو إيش + +422 +00:30:43,620 --> 00:30:47,760 +قلنا بنشوف فيه؟ بنشوف فيه ring cedroblast وبشوف + +423 +00:30:47,760 --> 00:30:53,760 +macro phages كبيرة مصبوغة بالمخ تصبغة الحديد ليش؟ + +424 +00:30:53,760 --> 00:30:56,280 +لأنه هتلاقي يعني البولمارو اللون بتاعه لما أصبغ + +425 +00:30:56,280 --> 00:30:59,780 +بليبروجيني blue ماخد أو مكتسح اللون الأزرق لأن + +426 +00:30:59,780 --> 00:31:05,580 +الحديد فيه بزيادة ثاني شيء لنوع آخر من أنواع + +427 +00:31:05,580 --> 00:31:08,780 +الانيميا اللي بتكون غالبا microcytic micro + +428 +00:31:08,780 --> 00:31:13,650 +hypochromicاللي هي Anemia of Chronic Disease هنا + +429 +00:31:13,650 --> 00:31:22,350 +Inability to use iron يعني الخلايا ما بتقدر تستخدم + +430 +00:31:22,350 --> 00:31:26,430 +الـ Iron لتصنيع الـ Hemoglobin وكمان بتحس .. يعني + +431 +00:31:26,430 --> 00:31:32,410 +بيصير في response للـ Erythrobiotin أقل طبعاً يعني + +432 +00:31:32,410 --> 00:31:36,230 +سبب شائع من أسباب الـ Anemia طيب، الحالات المرضية + +433 +00:31:36,230 --> 00:31:39,790 +اللي بشوف فيها Anemia زي Rheumatoid Arthritis + +434 +00:31:40,440 --> 00:31:44,540 +Chronic Renal Disease Thyroid Disease Malignancies + +435 +00:31:44,540 --> 00:31:49,200 +Tuberculosis Chronic Fungal Infection هذه حالات + +436 +00:31:49,200 --> 00:31:54,600 +مرضية شائعة في حدوث أنيميا Anemia of chronic + +437 +00:31:54,600 --> 00:31:57,960 +disease pathogenesis إيش اللي بيصير في الانيميا of + +438 +00:31:57,960 --> 00:32:02,220 +chronic disease؟ الانيميا of chronic disease عادة + +439 +00:32:02,220 --> 00:32:06,000 +يعني ممكن يصير فيها inflammation الinflammation + +440 +00:32:06,000 --> 00:32:08,940 +بصاحب مجموعة من خلايا المناعة بما فيها الـ + +441 +00:32:08,940 --> 00:32:13,480 +neutrophilلـ Neutrophil حبيباتها فيها مادة اسمها + +442 +00:32:13,480 --> 00:32:18,820 +الـ Lactoferrin تمام؟ الـ Lactoferrin هذا بيشبه أو + +443 +00:32:18,820 --> 00:32:23,280 +بينافس لـ Transferrin في عمله فبيروح و هو مرتبط + +444 +00:32:23,280 --> 00:32:27,200 +بالحديد و موديه لـ Macrophage بتاعة liver cell + +445 +00:32:27,200 --> 00:32:31,940 +بالتالي الجسم مش هيقدر يستفيد من الحديد اللي مرتبط + +446 +00:32:31,940 --> 00:32:35,740 +بالـ Lactoferrin نشوف Lactoferrin is an iron + +447 +00:32:35,740 --> 00:32:42,470 +binding proteinin the granules of neutrophil it is + +448 +00:32:42,470 --> 00:32:46,230 +ability for iron is greater than transferrin يعني + +449 +00:32:46,230 --> 00:32:49,490 +بيحب يرتبط بالiron أكتر مما بيفعل transferrin + +450 +00:32:49,490 --> 00:32:53,890 +during infection or inflammation neutrophil + +451 +00:32:53,890 --> 00:32:56,510 +lactoferrin released into plasma and hunt + +452 +00:32:56,510 --> 00:33:00,350 +available iron بروح هو مقتنظ ال iron الموجود ماسك + +453 +00:33:00,350 --> 00:33:04,590 +فيه؟ bind to macrophage هيرتبط مع ال macrophage + +454 +00:33:04,590 --> 00:33:09,820 +and liver cellsوبالتالي ليش؟ لأنه فيها receptor + +455 +00:33:09,820 --> 00:33:13,240 +لـLactoferrin فبالتالي احنا ما استفدنا من الحديد + +456 +00:33:13,240 --> 00:33:17,880 +وهذا طبعا من الأسباب الشائعة لحدوث أنيميا في هذا + +457 +00:33:17,880 --> 00:33:20,960 +السبب، في سبب تاني أنه في الـinflammatory disease + +458 +00:33:20,960 --> 00:33:23,620 +وفي الأمراض هذه بشكل عام تطلع الـcytokines + +459 +00:33:23,620 --> 00:33:28,260 +الـcytokines هذه بتنتج من الـmacrophages والخلايا + +460 +00:33:28,260 --> 00:33:33,940 +المناعة هذه عادة بتأثر على الـerythrobesis يعني + +461 +00:33:33,940 --> 00:33:39,440 +بتعملفي الـ Early Stage منها الـ Lab Finding نيجي + +462 +00:33:39,440 --> 00:33:42,300 +للـ Lab Diagnosis في الـ Early Stage بلاقي + +463 +00:33:42,300 --> 00:33:45,560 +الانيميا normocytic-normochromic بعدين بتبدأ تتطور + +464 +00:33:45,560 --> 00:33:50,140 +لhypochromic microcytic بلاقي leukocytosis لأن وضع + +465 +00:33:50,140 --> 00:33:53,280 +inflammation abundant storage of iron in + +466 +00:33:53,280 --> 00:33:57,280 +macrophage يعني في iron كتير ليش؟ لأن مافيش + +467 +00:33:57,280 --> 00:33:59,280 +استخدام جيد للـ iron + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM_raw.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..44941ae51ff7383b0dc490726d3cafd33f8d77fd --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/aynK969TbyM_raw.srt @@ -0,0 +1,1868 @@ +1 +00:00:01,690 --> 00:00:06,950 +الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبابتتقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +التلاتة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش أني أحفظ إيش تعريف الانيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش ال pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط النتائج هذه مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مساحبة لهذا ال result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,790 +على فحوصات عشان أتأكد من results معينة هذا الكلام + +20 +00:01:32,790 --> 00:01:36,810 +بإذن الله كله راح نناقشه مع بعض شويه شويه أول حاجة + +21 +00:01:36,810 --> 00:01:37,710 +هنشرحه بعد + +22 +00:01:53,700 --> 00:01:58,300 +الطريقة الأولى أو المعيار الأول لتصنيف الأنيميا + +23 +00:01:58,300 --> 00:02:02,800 +اللى هو الـ morphology للخلايا تم تصنيف الخلايا + +24 +00:02:02,800 --> 00:02:08,680 +حسب الـ MCV إلى تلت مجموعات Microcytic، + +25 +00:02:08,680 --> 00:02:13,220 +Normocytic، Macrocytic هذا التصنيف اللى إحنا هنمشي + +26 +00:02:13,220 --> 00:02:18,460 +عليه المعيار التانى في التصنيف كان الـ + +27 +00:02:18,460 --> 00:02:22,180 +Pathophysiology حسب الميكانزم أو قليل حدوث المرض + +28 +00:02:22,180 --> 00:02:27,080 +أو سبب المرضطبعاً أول حاجة اللي هو Embared + +29 +00:02:27,080 --> 00:02:30,860 +Erythrocyte Formation أنه في خلل في تصنيع الـ + +30 +00:02:30,860 --> 00:02:38,800 +Erythrocyte قد يكون هذا الخلل بسبب Primary Problem + +31 +00:02:38,800 --> 00:02:42,060 +في البون مارو يعني مشكلة أساسية في البون مارو زي + +32 +00:02:42,060 --> 00:02:45,420 +حالات الأبلاستيك أنيميا يعني خلل في البون مارو ما + +33 +00:02:45,420 --> 00:02:49,790 +بيقدر يصنع خلايا بشكل كافيأو خلال في تصنيع .. في + +34 +00:02:49,790 --> 00:02:53,470 +كمية .. يعني قدرته على تصنيع الـ Hemoglobin لأنه + +35 +00:02:53,470 --> 00:02:57,410 +في مثلا نقص حديد زي Iron Deficiency Anemia زي + +36 +00:02:57,410 --> 00:02:59,450 +Sidroblastic Anemia اللي بيبقى فيها خلال في + +37 +00:02:59,450 --> 00:03:03,410 +البروتوبرفيرين يعني أمثلة تانية الأنيميا أو الـ + +38 +00:03:03,410 --> 00:03:07,190 +Chronic Disease Megaloplastic Anemia إذا هنا في كل + +39 +00:03:07,190 --> 00:03:11,050 +هذه الحالات تشترك في شغلة إنه في خلال في الـ + +40 +00:03:11,050 --> 00:03:13,890 +Formation للـ RBCs يعني الـ RBCs كميتها هتكون + +41 +00:03:13,890 --> 00:03:17,860 +قليلة في الحالات هذه بشكل عامRBC قليلة + +42 +00:03:17,860 --> 00:03:22,060 +وReticulocyte قليلة هنا الـ «بون مارو» ما بيقدرش + +43 +00:03:22,060 --> 00:03:25,140 +يستجيب مع المرض يعني حتى لو كان فيه أنيميا البون + +44 +00:03:25,140 --> 00:03:28,220 +مارو ما بيقدر يصنع لأنه فيه نقص في العناصر + +45 +00:03:28,220 --> 00:03:31,760 +الأساسية اللي لازمة للتصنيع فقد ما يكون فيه نقص مش + +46 +00:03:31,760 --> 00:03:35,840 +هيقدر يعودها مهما اجتهد و مهما اشتغل مش هيقدر لأنه + +47 +00:03:35,840 --> 00:03:38,340 +إلا إذا إحنا أعطينا يعني مثلا فيه نقص حديد بنعطي + +48 +00:03:38,340 --> 00:03:42,300 +حديد بتشط البون مارو تمام؟ فيه نقص مثلا + +49 +00:03:45,920 --> 00:03:49,700 +الـ group التانية في هذه ال category اللي هي + +50 +00:03:49,700 --> 00:03:53,240 +increased blood loss إنه فيه فقد للـ blood قد يكون + +51 +00:03:53,240 --> 00:03:57,100 +بسبب bleeding acute or chronic عادة ال + +52 +00:03:57,100 --> 00:04:01,260 +reticulocyte هنا بتكون عالية لأنه مافي خلل في + +53 +00:04:01,260 --> 00:04:05,960 +البومارو و عنده القدرة إنه يعوض أي نزف أو أي فقد + +54 +00:04:05,960 --> 00:04:09,880 +من ال blood فبنلاقي ال reticulocyte عاليةطبعاً + +55 +00:04:09,880 --> 00:04:14,700 +إمتى بتصير هذه إذا كانت كمية إمتى بتصير الانيميا + +56 +00:04:14,700 --> 00:04:19,580 +صح البولمارو بيشطل لكن إذا فاق أو زاد كمية الفاقد + +57 +00:04:19,580 --> 00:04:22,980 +عن قدرة البولمارو على إنه يعودها فبيختلي الbalance + +58 +00:04:22,980 --> 00:04:27,140 +ما بين الفاقد وما بين الجديد أو المتكون أو المتصنع + +59 +00:04:27,140 --> 00:04:31,820 +الجديد فبالتالي بينشأ عندنا نوع من الانيمياالنوع + +60 +00:04:31,820 --> 00:04:34,400 +التالت أو المجموعة التالتة اللي هي increase + +61 +00:04:34,400 --> 00:04:38,080 +destruction of RBCs ده كتير اللي هي بنسميها احنا + +62 +00:04:38,080 --> 00:04:41,680 +hemolytic anemia هنا برضه ال reticulocyte count + +63 +00:04:41,680 --> 00:04:48,460 +بيكون عالي ونفس الشيء نيجي للتصنيف التانية اللي هي + +64 +00:04:48,460 --> 00:04:52,860 +حسب ال morphology حسب ال morphology في عندنا + +65 +00:04:52,860 --> 00:04:57,800 +normocytic normochromic anemia بداية طبعا قلنا + +66 +00:04:57,800 --> 00:05:03,850 +normocyticMicro-Cytic وMacro-Cytic ناخد أولا الـ + +67 +00:05:03,850 --> 00:05:08,410 +Normocytic Normocytic نورمو كروميك أنيميا هنا يعني + +68 +00:05:08,410 --> 00:05:13,590 +مافي خلل في الـ RBCs يعني الـ RBCs مافيش فيها + +69 +00:05:13,590 --> 00:05:16,430 +مشكلة خالص لا فيها نقص حديد ولا في خلل في حجمها + +70 +00:05:16,430 --> 00:05:21,570 +ولا في خلل في تصنيعها بس فيه بطء في عمليةفي خلال + +71 +00:05:21,570 --> 00:05:25,790 +معين ما أثر على الخلية وعلى وظيفتها لكن صار بطء في + +72 +00:05:25,790 --> 00:05:29,210 +تصنيع هذه الخلية في مشكلة في تصنيعها بس مش في + +73 +00:05:29,210 --> 00:05:32,670 +مكوناتها وفي قدرتها على العمل تمام فهذه الخلية + +74 +00:05:32,670 --> 00:05:37,150 +بتكون طبيعية normocytic محتواها من ال hemoglobin + +75 +00:05:37,150 --> 00:05:43,890 +طبيعي تمام لكن في مشكلة زي مثلا blood loss صار فقد + +76 +00:05:43,890 --> 00:05:47,310 +للدم الخلايا ما بتأثر شكلها ولا بتأثر ال + +77 +00:05:47,310 --> 00:05:51,110 +hemoglobin اللي فيها لكن بتأثر عددها تمامHemolytic + +78 +00:05:51,110 --> 00:05:54,030 +Anemia أبلاستيك أنيميا أبلاستيك أنيميا الخلايا + +79 +00:05:54,030 --> 00:05:57,990 +تتصنع خلايا كويسة لكن المشكلة إنه ما بتتصنع بالعدد + +80 +00:05:57,990 --> 00:06:00,990 +الكافي المناطق اللي بتشتغل في الـ bone marrow مش + +81 +00:06:00,990 --> 00:06:06,150 +كتيرة المناطق النشطة اللي بتصنع خلايا في حالات الـ + +82 +00:06:06,150 --> 00:06:08,730 +Chronic Diseases برضه في حالات الـ Renal + +83 +00:06:08,730 --> 00:06:09,490 +Insufficiency + +84 +00:06:15,800 --> 00:06:18,620 +الـ Renal Insufficiency اللي حكيناها طوي طبعاً + +85 +00:06:18,620 --> 00:06:22,220 +بيصير خلل في الـ Erythrobiotin ما بتطلعش بشكل كافي + +86 +00:06:22,220 --> 00:06:25,420 +فبالتالي ما بيصيرش stimulation للـ bone marrow + +87 +00:06:25,420 --> 00:06:29,000 +بشكل كافي وبالتالي ما بيطلعش خلايا كثير عشان ما + +88 +00:06:29,000 --> 00:06:34,440 +أرجع للشريحة هذه تمام نيجي للنوع التاني Microcytic + +89 +00:06:34,440 --> 00:06:38,060 +وعادة ال microcytic hypochromic بيكون كل ال blood + +90 +00:06:38,060 --> 00:06:41,880 +indices قليلة ال MCV له حجم الخلية قليل محتوى ال + +91 +00:06:41,880 --> 00:06:46,880 +Hemoglobin MCH و MCHC برضه قليلهذه مجموعة دايمًا + +92 +00:06:46,880 --> 00:06:49,940 +بنقول اللي هي بتشمل الـ Iron deficiency anemia + +93 +00:06:49,940 --> 00:06:53,060 +سيدرو بلاستيك أنيميا حالات الـ Lead poisoning + +94 +00:06:53,060 --> 00:06:59,120 +حالات الثلاثيميا حالات الـ Chronic diseases نيجي + +95 +00:06:59,120 --> 00:07:02,960 +للنوع التالت اللي هو Macrocytic Normochromate + +96 +00:07:02,960 --> 00:07:09,640 +خلاية كبيرة في الحجم MCV لها عالي والـ MCH والـ + +97 +00:07:09,640 --> 00:07:13,760 +MCHCممكن تكون Normal لأن محتوى الـ Hemoglobin + +98 +00:07:13,760 --> 00:07:17,340 +يتناسب بحجم الخلية في حالات الـ megaloplastic + +99 +00:07:17,340 --> 00:07:21,840 +anemia في حالات liver diseaseفي حالات بعد الـ + +100 +00:07:21,840 --> 00:07:25,560 +splenectomy في حالات الـ hypothyroidism في حالات + +101 +00:07:25,560 --> 00:07:28,340 +stress erythropoiesis يعني اللي بيقول مرة بيشتغل + +102 +00:07:28,340 --> 00:07:31,960 +تحت stress فبالتالي بيطلع خلايا لسه مش mature + +103 +00:07:31,960 --> 00:07:34,760 +كفاية اللي هي الـ reticulocyte اللي حكينا عنها + +104 +00:07:34,760 --> 00:07:39,180 +بتطلع بعدد كبير وطبعاً هذه أكبر شوية من الـ RBCs + +105 +00:07:39,180 --> 00:07:43,600 +العادية فبالتالي بالمجمل بتزود الـ MCV بتاع الـ + +106 +00:07:43,600 --> 00:07:50,750 +blood بتاع الـ RBCsهنا تصنيفة الخلايا حسب الـ + +107 +00:07:50,750 --> 00:07:55,710 +Morphology في عندي ثلاث صور من ثلاث أفلام واحد + +108 +00:07:55,710 --> 00:08:01,210 +فيهم Normal طبعا إذا فكرين قلنا بنقيس الحجم بنواة + +109 +00:08:01,210 --> 00:08:06,150 +الـ Lymphocyte لأنه يعني بدي حاجة Standard أقيس + +110 +00:08:06,150 --> 00:08:09,790 +عليها فبعتبر نواة الـ Lymphocyte Standard لو أجينا + +111 +00:08:09,790 --> 00:08:13,980 +هنا هنلاقي الفيلم هذا «Norma 6» «Norma Comics»هنا + +112 +00:08:13,980 --> 00:08:17,980 +هنلاقي الخلايا الصغيرة Microcytic وبرضه كمية الـ + +113 +00:08:17,980 --> 00:08:21,120 +Hemoglobin فيها قليلة طبعا إذا كنتوا فاكرين كمية + +114 +00:08:21,120 --> 00:08:24,960 +الـ Hemoglobin لازم أو المنطقة الفاضية عفوا ما + +115 +00:08:24,960 --> 00:08:29,220 +تزيدش عن طولة الخلية زي هات لكن هنا المنطقة + +116 +00:08:29,220 --> 00:08:32,240 +الفاضية زادت عن طولة الخلية فبسميها Hypochromic + +117 +00:08:32,240 --> 00:08:36,880 +هنا Microcytic Normochromic Microcytic لأنه زي ما + +118 +00:08:36,880 --> 00:08:40,920 +أنتوا شايفين الخلايا كبيرة مقارنة بنواة الـ + +119 +00:08:40,920 --> 00:08:49,610 +lymphocyte معظمها خلاياMacrocytic تمام هيجي في أول + +120 +00:08:49,610 --> 00:08:53,870 +نوع Microcytic Hypochromic AnemiaMicrocytic + +121 +00:08:53,870 --> 00:08:57,770 +Hypochromic Anemia التصنيفات اللي حكيناهم طوي + +122 +00:08:57,770 --> 00:09:02,050 +هنبلش ناخدهم بالتفصيل و هيهمني أنا أكتر حاجة الـ + +123 +00:09:02,050 --> 00:09:05,470 +differential diagnosis لإلهم كيف بميزهم عن بعض + +124 +00:09:08,810 --> 00:09:13,730 +أول حاجة بتتميز هذه يعني في .. في لها صفات هتلاقي + +125 +00:09:13,730 --> 00:09:18,410 +إن الـ RBCs صغيرة كلها يعني ال .. ال .. ال .. طبعا + +126 +00:09:18,410 --> 00:09:23,130 +Microcytic هيكون حجمها صغيرة المنطقة الوسطى اللي + +127 +00:09:23,130 --> 00:09:26,270 +هي الـ Central Palar Area هتلاقيها كبيرة لأنها + +128 +00:09:26,270 --> 00:09:31,530 +Microcytic Hypochromic Cells هذه الخلايا أو هذه + +129 +00:09:31,530 --> 00:09:37,150 +الحالات المرضية بتشمل Iron Deficiency Anemia + +130 +00:09:37,150 --> 00:09:41,420 +تلسيمياAnemia of Chronic Disease سيدرو بلاستيك + +131 +00:09:41,420 --> 00:09:45,180 +أنيميا led poisoning هذه صورة blood film زي ما + +132 +00:09:45,180 --> 00:09:49,020 +انتوا شايفين الخلايا الميتهيموجلبيين فيها قليلة + +133 +00:09:49,020 --> 00:09:54,020 +جدا بالاضافة لأن حجم الخلايا برضه صغير مقارنة + +134 +00:09:54,020 --> 00:10:00,320 +بنواة الينفوسايت الآن + +135 +00:10:00,320 --> 00:10:03,920 +بشكل عام بالنسبة لـMicrostatic Hypochromic Anemia + +136 +00:10:04,750 --> 00:10:07,950 +طبعا احنا عارفين ان الـ Hemoglobin بتكون من Hem + +137 +00:10:07,950 --> 00:10:13,410 +-Andoglobin تمام؟ Hem-Andoglobin قد يكون الخلل في + +138 +00:10:13,410 --> 00:10:18,590 +تصنيع الـ Hem نفسه الـ Hem مكون من Protoporphyrin + +139 +00:10:18,590 --> 00:10:24,590 +رنج 4 مع حديد صح؟ إذا صار الـ defect أو النقص في + +140 +00:10:24,590 --> 00:10:29,530 +كمية الحديدهتنتج عندي iron deficiency أنميا + +141 +00:10:29,530 --> 00:10:34,030 +وأحياناً برضه بتكون مصاحبة لـ chronic inflammation + +142 +00:10:34,030 --> 00:10:40,650 +أو أنميا of a chronic disease طبعاً لو صار في خلل + +143 +00:10:40,650 --> 00:10:46,110 +في تصنيع البروتو بورفيرين وتكونه برضه مش هيتكون + +144 +00:10:46,110 --> 00:10:50,350 +الهيم بشكل كافي فبالتالي بتنشأ عندي أو تتكون عندي + +145 +00:10:50,350 --> 00:10:53,940 +الـ cedroplastic أنميابينما لو صار الخلل في + +146 +00:10:53,940 --> 00:10:57,000 +الغلوبين الـChan Alpha أو Beta تطلع عندى + +147 +00:10:57,000 --> 00:11:03,720 +الثلاثيمية طبعا والأنواع هذه كلهاتها تتميز بأنها + +148 +00:11:03,720 --> 00:11:07,280 +Micro City Hypoxia هنا بنحكي عن الأسباب يعني إما + +149 +00:11:07,280 --> 00:11:10,820 +خلل في تصنيع الهيم أو الغلوبين الهيم قد يكون سببه + +150 +00:11:10,820 --> 00:11:15,260 +مشكلة بالـIron أو مشكلة بالبروتوبرفرين كل واحدة + +151 +00:11:15,260 --> 00:11:17,720 +بتطلع عندى نوع مختلف من الأنميا + +152 +00:11:20,430 --> 00:11:24,810 +هنا لو تخيلنا هذا Normal Plastic Maturation هذا + +153 +00:11:24,810 --> 00:11:29,450 +الحجم الطبيعي للخلايا خلال الـ Maturation لكن الـ + +154 +00:11:29,450 --> 00:11:32,670 +Microcytic Anemia هتبقى الخلايا من الأساس هتبقى + +155 +00:11:32,670 --> 00:11:36,410 +صغيرة ويصير الـ differentiation وتطلع عندي بالآخر + +156 +00:11:36,410 --> 00:11:42,550 +mature erythrocyte توصف بأنها Microcytic Cell + +157 +00:11:42,550 --> 00:11:47,530 +دعونا نبدأ بالـ Iron Deficiency Anemia لأن هي أكثر + +158 +00:11:47,530 --> 00:11:51,700 +أنواع الأنيميا انتشراالـ Iron deficiency anemia + +159 +00:11:51,700 --> 00:11:55,220 +تنتج + +160 +00:11:55,220 --> 00:12:01,800 +من نقص الحديد في الجسم طبعاً هينعكس على الـ Serum + +161 +00:12:01,800 --> 00:12:07,460 +Iron هنلاقي فيه نقص طبعاً نقص الحديد هيؤدي لخلل في + +162 +00:12:07,460 --> 00:12:11,540 +تصنيع الهيم وبالتالي نقص في الـ Hemoglobin وهذا + +163 +00:12:11,540 --> 00:12:16,300 +بينتج عنه Iron deficiency anemia تشكل أكتر من + +164 +00:12:16,300 --> 00:12:17,040 +نصحلات + +165 +00:12:19,650 --> 00:12:22,610 +السبب الأول والرئيسي اللي هو nutritional + +166 +00:12:22,610 --> 00:12:26,170 +deficiency طبيعة الأكل، الاهتمام بالخضار، + +167 +00:12:26,170 --> 00:12:28,770 +بالفواكه، باللحوم، بالعناصر الغذائية، الهمة + +168 +00:12:28,770 --> 00:12:33,130 +بالطعام طيب، في ناس تيجي بتقولك أنا أكل كويس + +169 +00:12:33,130 --> 00:12:37,590 +ومتوازن لكن هي بتلاقي الدم عندها الـHemoglobin + +170 +00:12:37,590 --> 00:12:41,930 +عندها ما بيرتفع ممكن يكون سببها إن في عندهم + +171 +00:12:41,930 --> 00:12:46,140 +malabsorption، في خلل في امتصاص الحديدهذا يعني + +172 +00:12:46,140 --> 00:12:50,640 +ممكن يكون خلل طبيعي يعني أو يعني مخلوق فيه عيب + +173 +00:12:50,640 --> 00:12:54,560 +خلقي إنه في عندها الحديد ما بينتصب الشكل الجيد أو + +174 +00:12:54,560 --> 00:12:59,660 +نتيجة عادة غذائية سيئة يعني مثلا إحنا عارفين إنه + +175 +00:12:59,660 --> 00:13:03,100 +بالـ calcium والحديد الـ calcium بيعكس على الحديد + +176 +00:13:03,100 --> 00:13:07,380 +صح أو إنه مثلا بعد لو الواجبات اللي فيها الحديد + +177 +00:13:07,380 --> 00:13:11,760 +بتاخد شاي الشاي بيأثر عن تصاص الحديد فيعني هذه قصة + +178 +00:13:11,760 --> 00:13:16,180 +الـ absorptioninefficient transport storage or + +179 +00:13:16,180 --> 00:13:19,080 +utilization of iron يعني فيه مشكلة في نقل الحديد + +180 +00:13:19,080 --> 00:13:22,380 +وفي تخزينه وفي الـ height تبعه واستهلاكه في الجسم + +181 +00:13:22,380 --> 00:13:29,080 +increased need يعني في حاجة زائدة أو فائدة للحديد + +182 +00:13:29,080 --> 00:13:34,080 +في الجسم chronic blood loss الفاقد بزيادة زي ما + +183 +00:13:34,080 --> 00:13:39,740 +يكون فيه نزيف أو ulcer أو heavy menstruation طبعا + +184 +00:13:39,740 --> 00:13:43,930 +عارفين مصادر الحديد قد تكون حيوانية وقد تكوننباتية + +185 +00:13:43,930 --> 00:13:49,950 +بيبين + +186 +00:13:49,950 --> 00:13:54,670 +ايش الاحتياج اليومي للحديد حسب الفئة العمرية وحسب + +187 +00:13:54,670 --> 00:14:00,510 +التوزيع ال iron في الجسم هذه كويسة يعني عندنا ال + +188 +00:14:00,510 --> 00:14:04,830 +iron موجود 65% بيكون منه في الحديد في ال + +189 +00:14:04,830 --> 00:14:09,460 +hemoglobin عفوافي الريتين و الهيموسيدرين كمخزون + +190 +00:14:09,460 --> 00:14:13,180 +بنلاقي تلاتين تقريبا في المية ال myoglobin بنلاقي + +191 +00:14:13,180 --> 00:14:16,200 +فيه تلاتة و نصف في المية ال hem enzymes تقريبا نصف + +192 +00:14:16,200 --> 00:14:20,200 +في المية هنا point one transferring bound iron + +193 +00:14:20,200 --> 00:14:25,720 +بتلاقي كمية من الحديد مرتبطة فيه داخل ال iron + +194 +00:14:25,720 --> 00:14:31,020 +deficiency anemia طبعا لو صار فيه فقد لل iron أو + +195 +00:14:34,480 --> 00:14:38,040 +يعني إنه إحنا محتاجين حديد بزيادة في الجسم زيادة + +196 +00:14:38,040 --> 00:14:42,580 +التصنيع أو هيك إشي طبعاً هيصير استهلاك بزيادة + +197 +00:14:42,580 --> 00:14:46,780 +للحديد وإذا كان الإنسان مابياخدش الكمية الكافية عن + +198 +00:14:46,780 --> 00:14:50,540 +طريق الغذاء هتبدأ تتطور عنده الـ Iron deficiency + +199 +00:14:50,540 --> 00:14:56,680 +anemiaأول حاجة مرحلة انه يعني الـ Peripheral blood + +200 +00:14:56,680 --> 00:15:00,380 +والـ RBCs ما بتتغير وحتى الـ Serum ما بتتغير فيه + +201 +00:15:00,380 --> 00:15:03,860 +منسوب الحديد بيبدأ ينقص وين في ال stars احنا + +202 +00:15:03,860 --> 00:15:06,960 +عارفين انه ال stars بتاعة الحديد في الأنسجة + +203 +00:15:06,960 --> 00:15:10,960 +الفيريتين فبنلاقي و الفيريتين بيكون نسبة بسيطة منه + +204 +00:15:10,960 --> 00:15:15,240 +في ال bloodبسيطة جدا يعني وفي توازن مع لف الأنسجة + +205 +00:15:15,240 --> 00:15:18,780 +فلو نقصة طلف السيرام معنى الكلام أنه صار فيه نقص + +206 +00:15:18,780 --> 00:15:23,100 +في الحديد المخزن يعني أول حاجة بيبدأ الحديد من وين + +207 +00:15:23,100 --> 00:15:27,620 +يسحب يسحب من المخزون من الفرتين وهذا بينعكس على + +208 +00:15:27,620 --> 00:15:32,800 +الفرتين الموجود بالسيرام يعني أول مرحلة أن السيرام + +209 +00:15:32,800 --> 00:15:36,720 +Iron بيكون طبيعي بياخد Iron من المخزنالـ Total + +210 +00:15:36,720 --> 00:15:40,540 +Iron Binding Capacity طبيعية مافيش أنيميا، مافيش + +211 +00:15:40,540 --> 00:15:44,100 +أي أعراض الـ RBCs Normal نورموستيك، نورموكروميك + +212 +00:15:44,100 --> 00:15:48,520 +لكن وين بتبدأ تبين المشكلة؟ في الفيريتين بيكون الـ + +213 +00:15:48,520 --> 00:15:52,400 +Serum في الفيريتين قليل لأن هنا بلش الحديد ينسحب + +214 +00:15:52,400 --> 00:15:56,720 +من الـ Iron Stars بيتبلش ينسحب من المخازن فبيبدأ + +215 +00:15:56,720 --> 00:16:01,680 +ينقص الفيريتين المرحلة التانية بيبدأ ينقص الـ + +216 +00:16:01,680 --> 00:16:05,730 +Serum Iron بس لسه الـ RBCs ما اتغيرتسيرام ايرن + +217 +00:16:05,730 --> 00:16:09,970 +بنقص الـ Total Iron Binding Capacity بتنقص وبرضه + +218 +00:16:09,970 --> 00:16:15,530 +خدوبة لكم الفرتين من الأساس هو أصلا ناقص لكن ما + +219 +00:16:15,530 --> 00:16:19,330 +بيكون لسه فيه أنيميا ال RBC's بتكون طبيعية المرحلة + +220 +00:16:19,330 --> 00:16:25,730 +التالتةإنه يعني خلاص انسحبت المخازن والحديد اللي + +221 +00:16:25,730 --> 00:16:29,750 +بيتاخد ما بيكفي إنه نصنع Hemoglobin كويس فبنعدّي + +222 +00:16:29,750 --> 00:16:34,010 +في المرحلة التالتة اللي هي مرحلة الأنيميا الحقيقية + +223 +00:16:34,010 --> 00:16:38,010 +إنه الـ Iron stores فضيت الحديد نزل في الـ Serum + +224 +00:16:38,010 --> 00:16:41,150 +فبالتالي بتبدأ الأنيميا تظهر اللي هي Microcytic + +225 +00:16:41,150 --> 00:16:45,150 +Hypochromic Anemia أو Microcytic HypochromicRed + +226 +00:16:45,150 --> 00:16:49,290 +cells وبتنشأ حالة Iron deficiency anemia يعني مش + +227 +00:16:49,290 --> 00:16:53,630 +من أول ما بيبدأ ينقص ال iron بنبدأ احنا لل + +228 +00:16:53,630 --> 00:16:57,970 +symptoms بتاعة ال iron deficiency anemia طبعا فينا + +229 +00:16:57,970 --> 00:17:02,110 +fatigue, dizziness, headache فينا برضه بعض ال + +230 +00:17:02,110 --> 00:17:05,030 +signs المميزة لل iron deficiency anemia زي ال + +231 +00:17:05,030 --> 00:17:12,670 +smooth tongue زي ال stomatitis اللي هي في الأظافر + +232 +00:17:12,670 --> 00:17:19,950 +وتشققطبعاً هذا من علامات الـ Iron نيجي لل lab + +233 +00:17:19,950 --> 00:17:24,190 +diagnosis of iron deficiency أنيميا فحصات خاصة + +234 +00:17:24,190 --> 00:17:28,310 +بالحديد فحصات خاصة بالحديد هذه ممكن نستخدمها عشان + +235 +00:17:28,310 --> 00:17:32,090 +نعمل differential diagnosis لل microcytic + +236 +00:17:32,090 --> 00:17:34,890 +hypochronic أنيميا لأنواعها المختلفة الميزها عن + +237 +00:17:34,890 --> 00:17:38,670 +بعض أو إذا كان في iron overload إذا كان في زيادة + +238 +00:17:38,670 --> 00:17:42,330 +في ال iron برضه ممكن نقيس ال ironطيب قبل ما نبدأ + +239 +00:17:42,330 --> 00:17:45,810 +نحكي في الـ Iron Test لنفهم شغلة مهمة كتير أنه أنا + +240 +00:17:45,810 --> 00:17:51,630 +اللي بقيسه Iron مرتبط بحاجة اسمها Transferrin إيش + +241 +00:17:51,630 --> 00:17:54,770 +هو الـ Transferrin؟ هو عبارة عن بروتين ناقل + +242 +00:17:54,770 --> 00:17:59,470 +للحديد، تمام؟ عادة للـ Transferrin هذا بلاقي منه + +243 +00:17:59,470 --> 00:18:06,050 +33% مرتبط بالـ Iron والباقي بيكون مش مرتبط، كويس؟ + +244 +00:18:06,050 --> 00:18:11,420 +طيب، فأنا عندي تحوصات بعملها الـ Serum Ironالـ + +245 +00:18:11,420 --> 00:18:15,900 +Serum Iron يا بنات هو فعليًا الـ Serum العفواني + +246 +00:18:15,900 --> 00:18:18,680 +الـ Iron المرتبط بالـ Transferring يعني أنا هي هذه + +247 +00:18:18,680 --> 00:18:24,600 +الـ 33% بدي أقدر قدش .. قدش هي تركزها تمام الـ + +248 +00:18:24,600 --> 00:18:30,320 +Total Iron Binding Capacity هذه بأقيص فيها قدش في + +249 +00:18:30,320 --> 00:18:34,860 +عندي حديد قادر يرتبط بـ Transferring بمعنى آخر قدش + +250 +00:18:34,860 --> 00:18:41,010 +في عندي Transferring Free كل مكان الحديد أقلتمام، + +251 +00:18:41,010 --> 00:18:44,490 +هيكون الـ Transferrin Free أكتر فهذه علاقتها عكسية + +252 +00:18:44,490 --> 00:18:51,490 +مع الـ Iron طيب، Serum Iron Level بدايتان قلتلكم + +253 +00:18:51,490 --> 00:18:54,690 +هو بنقيس من خلالها الـ Iron المرتبط بالـ + +254 +00:18:54,690 --> 00:18:59,530 +Transferrin طبعاً ما بقيس الـ Iron لـ Free، بقيس + +255 +00:18:59,530 --> 00:19:04,430 +المرتبط Total Iron Binding Capacity زي ما قلنا، هي + +256 +00:19:04,430 --> 00:19:07,700 +عبارة عن indirect measuredمن الـ amount of + +257 +00:19:07,700 --> 00:19:10,240 +transferin بروتين in the serum الترانسفيرين + +258 +00:19:10,240 --> 00:19:13,600 +الموجود اللي مش مرتبط اللي موجود بالـ serum طبعاً + +259 +00:19:13,600 --> 00:19:16,700 +و بديه زي ما قلنا هناك علاقة عكسية كل ما كان + +260 +00:19:16,700 --> 00:19:20,420 +الحديد أكتر كل ما كان الترانسفيرين الـ free أقل كل + +261 +00:19:20,420 --> 00:19:23,020 +ما كان الحديد قليل زي حالات الـ iron deficiency + +262 +00:19:23,020 --> 00:19:26,540 +أنيمية هتلاقي الترانسفيرين زاد فبالتالي هي + +263 +00:19:26,540 --> 00:19:29,340 +الترانسفيرين بيعبر عنها الـ total iron binding + +264 +00:19:29,340 --> 00:19:33,440 +capacity فبالتالي هيكون تناسب عكسي ما بين الـ TIPC + +265 +00:19:33,440 --> 00:19:37,840 +وما بين الـ iron في الجسمIf serum iron is + +266 +00:19:37,840 --> 00:19:40,440 +decreased, total iron binding capacity of + +267 +00:19:40,440 --> 00:19:43,940 +transferrin increase.Transferrin has more empty + +268 +00:19:43,940 --> 00:19:47,700 +space to carry iron يعني فيه فراغات أو أماكن فاضية + +269 +00:19:47,700 --> 00:19:53,920 +شاغرة من الـ iron نتيجة نقص الـ iron بالسيرام نيجي + +270 +00:19:53,920 --> 00:19:58,460 +للسيرام فريتين طبعا الفريتين هو بروتين بيتحكم في + +271 +00:19:58,460 --> 00:20:04,240 +تخزين الحديدالفرهتين هذا يعني موجود بشكل أساسي في + +272 +00:20:04,240 --> 00:20:07,700 +الأنسجة موجود كمية بسيطة منه في ال blood لكن + +273 +00:20:07,700 --> 00:20:11,460 +الكمية اللي في ال blood بتعكس عند صورة الموجود في + +274 +00:20:11,460 --> 00:20:16,240 +الأنسجةFound interest amount in plasma it is in + +275 +00:20:16,240 --> 00:20:19,080 +equilibrium with the body stars يعني فيه تناسب كل + +276 +00:20:19,080 --> 00:20:22,880 +ما كانت كميته كل ما قلت كميته في الـPlug أو في + +277 +00:20:22,880 --> 00:20:25,920 +الـSerum أو في الـPlasma معنى الكلام إنه نقص في + +278 +00:20:25,920 --> 00:20:29,960 +نقصة الـIron Stars أو نقص الحديد في مكازنه في + +279 +00:20:29,960 --> 00:20:33,740 +الانسجنVariation in the quantity of iron in the + +280 +00:20:33,740 --> 00:20:36,000 +storing environment is reflected by plasma + +281 +00:20:36,000 --> 00:20:38,460 +ferritin concentration نفس الكلام اللي قلناه يعني + +282 +00:20:38,460 --> 00:20:42,420 +لو نقص الحديد في المخزون الحديد في الأنسجة بنقص + +283 +00:20:42,420 --> 00:20:47,180 +الferritin اللي موجود في البلازمة كم تبقى نقص؟ في + +284 +00:20:47,180 --> 00:20:51,280 +مراحل مبكرة من ال iron deficiency أنميا و بزيد في + +285 +00:20:51,280 --> 00:20:56,460 +حالات الانميا أو ال chronic disease طبعا فينا هنا + +286 +00:20:56,460 --> 00:21:00,040 +ملاحظة بس بدنا ناخد بالنا منهابقولك في بعض حالات + +287 +00:21:00,040 --> 00:21:03,280 +الـ infection أو الـ inflammation سيرم في الـ + +288 +00:21:03,280 --> 00:21:08,900 +ريتين بزيد لأنه عبارة عن acute phase protein من + +289 +00:21:08,900 --> 00:21:11,780 +البروتينات اللي بتطلع في الـ acute phase + +290 +00:21:11,780 --> 00:21:17,830 +inflammation أو infectionطبعا هنا يعني هذه تعتبر + +291 +00:21:17,830 --> 00:21:21,310 +Indicator مش كتير صحيح أو الفيريتين يعتبر + +292 +00:21:21,310 --> 00:21:24,190 +Indicator مش كتير صحيح عن وضع الحديد في حالات ال + +293 +00:21:24,190 --> 00:21:26,790 +inflammation بس بدي أخد بالي لو في acute + +294 +00:21:26,790 --> 00:21:31,130 +inflammation أجل موضوع قياس الفيريتين شوية فلاش + +295 +00:21:31,130 --> 00:21:37,390 +يعطيني pause ابون مارو ايران يعني احنا خلصنا هيك + +296 +00:21:37,390 --> 00:21:41,740 +حكينا عن ال serum ironبنقيص المحتوى الحديد أو + +297 +00:21:41,740 --> 00:21:46,100 +دراسة الحديد الـ Iron Profile بنسميه بنقيص الـ + +298 +00:21:46,100 --> 00:21:49,320 +Iron بنقيص الـ Total Iron Binding Capacity اللي + +299 +00:21:49,320 --> 00:21:52,880 +بتعبر عن الترانسفيرين بنقيص الفيريتين خلصنا منهم + +300 +00:21:52,880 --> 00:21:56,120 +فلقيت الـ Bone Marrow Iron كيف بده أشوف الـ Bone + +301 +00:21:56,120 --> 00:22:00,160 +Marrow وضع الـ Iron فيه أول حاجة issue biopsy of + +302 +00:22:00,160 --> 00:22:04,380 +bone marrowممكن بالبروجياني بلوستين هذه صبغة خاصة + +303 +00:22:04,380 --> 00:22:08,780 +للحديد type of iron موجود في البونمارو هو + +304 +00:22:08,780 --> 00:22:13,300 +الهيموسيدرين يخزن في البونمارو على شكل هيموسيدرين + +305 +00:22:13,300 --> 00:22:20,860 +هنا صور هي هذه normal شايفين هذه صبغة البروجياني + +306 +00:22:20,860 --> 00:22:25,560 +بلو تصبغ مخزن الحديد الهيموسيدرين هنا مش موجود في + +307 +00:22:25,560 --> 00:22:27,980 +حالة ال iron deficiency مافيش عندى اللون الأزرق + +308 +00:22:27,980 --> 00:22:32,640 +خالص معناه الكلام ان في عندى أنمياIron deficiency + +309 +00:22:32,640 --> 00:22:38,660 +anemia طيب نيجي لل lab finding في الـ Iron + +310 +00:22:38,660 --> 00:22:45,520 +deficiency anemia law كل إشي law كل إشي law ما عدا + +311 +00:22:45,520 --> 00:22:49,600 +ال white pieces و ال platelets ال RBCs hemoglobin + +312 +00:22:49,600 --> 00:22:55,900 +hematocrit law ال MCV ال MCH ال MCHC برضه law ليش؟ + +313 +00:22:55,900 --> 00:22:59,780 +لأن حجم الخلايا صغير ومحتوها من الهمoglobin صغير + +314 +00:22:59,780 --> 00:23:04,620 +تمام؟يعني لو جينا لهذا الـ CPC الـ White PCs طبعا + +315 +00:23:04,620 --> 00:23:09,020 +الـ Platelets ما راح تتأثر الـ RPCs 2.9، + +316 +00:23:09,020 --> 00:23:16,400 +Hemoglobin 6.3، Hematocrit 24، MCV 69، MCH 1 يعني + +317 +00:23:16,400 --> 00:23:20,400 +كل الـ Parameters قليلة مع ده الـ Platelets و الـ + +318 +00:23:20,400 --> 00:23:27,160 +RPC و ال .. مع ده الـ Platelets و ال .. و ال White + +319 +00:23:27,160 --> 00:23:27,460 +PCs + +320 +00:23:32,520 --> 00:23:36,240 +الـ RBCs مورفولوجي لو احنا عملنا بلد فيلم بنلاقي + +321 +00:23:36,240 --> 00:23:40,100 +hypochromic microcytic cells بنلاقي anisocytosis + +322 +00:23:40,100 --> 00:23:44,020 +يعني التغير في أحجام الخلايا boiculocytosis ممكن + +323 +00:23:44,020 --> 00:23:47,100 +أشوف اللي هي الـ Pencil Cell خلية الـ Cigar Cell + +324 +00:23:47,100 --> 00:23:52,660 +خلية رفيعة كتير يعني زي الـ Electrocyte برضه ممكن + +325 +00:23:52,660 --> 00:23:58,160 +أشوف Target Cell طبعاً مابشوفش inclusion bodies في + +326 +00:23:58,160 --> 00:24:03,240 +الـ RBCs خالص Iron Parameters هلاقي الـ Ironلو الـ + +327 +00:24:03,240 --> 00:24:06,580 +Total Iron Binding Capacity عالي السيرام في + +328 +00:24:06,580 --> 00:24:12,320 +الريتين حلاقيه فليل هاي + +329 +00:24:12,320 --> 00:24:15,180 +عندنا blood film زي ما انتوا شايفين الخلايا كلها + +330 +00:24:15,180 --> 00:24:20,090 +تقريبا صغيرة هو احنا هنا مافيش عندناالانفوسايت + +331 +00:24:20,090 --> 00:24:23,970 +انقارن فيها لكن هو بقوللي ان الخلايا كلها صغيرة في + +332 +00:24:23,970 --> 00:24:26,910 +عندي الـEleptocyte اللي هي الـPencil Cell في عندي + +333 +00:24:26,910 --> 00:24:31,130 +الـOvalocyte هذه الـEleptocyte مش Ovalocyte هى هذه + +334 +00:24:31,130 --> 00:24:34,210 +الـOvalocyte فاكرين كيف بنفرق من الـOval و + +335 +00:24:34,210 --> 00:24:40,510 +الـElepto؟ الـElepto بتكون أرفع بحيث انه عرضها هذا + +336 +00:24:40,510 --> 00:24:45,930 +أقل من طولها أقل من ضعف طولها فهمتوا؟ عرضها أقل من + +337 +00:24:45,930 --> 00:24:51,300 +ضعف طولها بتكونالـ Leptocyte إذا كان عرضها أكتر من + +338 +00:24:51,300 --> 00:24:56,240 +ضعف طولها بتكون Ovalocyte وشايفين الـ Hypochromia + +339 +00:24:56,240 --> 00:24:58,920 +الواضحة في الخلايا إذن Anesocytosis and + +340 +00:24:58,920 --> 00:25:06,420 +Poikilocytosis مافيش inclusion bodies طيب + +341 +00:25:06,420 --> 00:25:11,240 +نيجي للـ Sidroblastic Anemia Sidroblastic Anemia + +342 +00:25:11,240 --> 00:25:14,180 +يمكن أنا نوحت في البداية في الـ Iron Deficiency + +343 +00:25:14,580 --> 00:25:19,160 +والـ Cedroplastic بتركوا التنتين في شغلة ان + +344 +00:25:19,160 --> 00:25:22,300 +التنتين في خلل في تصنيع الهيم وبالتالي الـ + +345 +00:25:22,300 --> 00:25:27,260 +Hemoglobin لكن الـ Iron deficiency الخلل في الحديد + +346 +00:25:27,260 --> 00:25:30,000 +الـ Cedroplastic في البروتوبرفيرين اللي بيكون + +347 +00:25:30,000 --> 00:25:33,880 +البروتوبرفيرين رينج بتاعة الهيم هي عبارة عن جروب + +348 +00:25:33,880 --> 00:25:37,700 +من الأنميا تتميز فيه defective protoperferin + +349 +00:25:37,700 --> 00:25:41,960 +synthesis طبعا هذا منتج عنه iron loading زيادة + +350 +00:25:41,960 --> 00:25:45,600 +للحديد الحديد مافيش فيه مشكلةلكن لأن الـ + +351 +00:25:45,600 --> 00:25:49,740 +Hemoglobin مش هيتصنع الحديد موجود، الـ Hemoglobin + +352 +00:25:49,740 --> 00:25:53,220 +مش هيتصنع فهيبدأ يتراكم الحديد ويزيد عكس الـ Iron + +353 +00:25:53,220 --> 00:25:56,460 +deficiency anemia تنتج عندنا Hypochromic anemia + +354 +00:25:56,460 --> 00:26:00,360 +نتيجة نقص تصنيع الـ Hemoglobin الـ blocks in + +355 +00:26:00,360 --> 00:26:03,920 +protoporphyrin synthesis lead to iron overload and + +356 +00:26:03,920 --> 00:26:06,860 +microcytic hypochromic anemia ملخص الـ + +357 +00:26:06,860 --> 00:26:07,540 +Acidroplastic + +358 +00:26:14,240 --> 00:26:18,300 +Cedrocite هي عبارة عن mature herbicides هذه في + +359 +00:26:18,300 --> 00:26:20,820 +الوضع الطبيعي أنا مابشوفهاش في الـ Peripheral + +360 +00:26:20,820 --> 00:26:27,720 +blood هي خلية فيها بقايا حديد granules متخزنة في + +361 +00:26:27,720 --> 00:26:31,020 +الـ mitochondria بتاعة الخلايا طبعا هذه أنا في + +362 +00:26:31,020 --> 00:26:34,340 +الوضع الطبيعي مابشوفها إذا كنتوا فاكرين لما حكينا + +363 +00:26:34,340 --> 00:26:37,840 +عن ال inclusion bodies حكينا فيه ترسبات حديد + +364 +00:26:37,840 --> 00:26:40,620 +أحيانا تظهر في الخلية في بعض الحالات المرضية + +365 +00:26:40,620 --> 00:26:44,770 +سميناها Pfeffenheimer bodiesالخلية اللي فيها + +366 +00:26:44,770 --> 00:26:48,550 +البابنهايمر بادرس هذه بسميها Sidrocyte وهذه مميزة + +367 +00:26:48,550 --> 00:26:54,150 +يعني لحالات Sidroblast كامية ليش؟ لأنه فيه زيادة + +368 +00:26:54,150 --> 00:26:58,510 +في الحديد Sidroblast هي عبارة عن Immature + +369 +00:26:58,510 --> 00:27:02,550 +nucleated RBCs in the bone marrow هيكون فيها كمية + +370 +00:27:02,550 --> 00:27:06,230 +من الحديد في الـCytoplasm هذه بتكون موجودة بشكل + +371 +00:27:06,230 --> 00:27:10,070 +طبيعي Sidroblast ليش؟ لأن الحديد طبيعي موجود في + +372 +00:27:10,070 --> 00:27:13,610 +الـbone marrow ومتخزنلكن إذا كنت بتكون Abnormal + +373 +00:27:13,610 --> 00:27:23,690 +شكل Ring Iron form a ring around the nucleus إذا + +374 +00:27:23,690 --> 00:27:27,910 +كان الحديد متخزن على شكل دائرة حوالين النواة هذه + +375 +00:27:27,910 --> 00:27:32,790 +تعتبر حالة مميزة لـCedroblastic Anemia وبسمي + +376 +00:27:32,790 --> 00:27:37,670 +الخلية في هذه الحالة Ring CedroblastRing + +377 +00:27:37,670 --> 00:27:40,410 +Sedroblast هنا Sedroblastic Anemia characterised + +378 +00:27:40,410 --> 00:27:43,370 +by the accumulation of iron in the mitochondria of + +379 +00:27:43,370 --> 00:27:46,670 +immature nucleated RBCs in the bone marrow على شكل + +380 +00:27:46,670 --> 00:27:51,590 +الـRing بسميها Ring Sedroblast وبتعتبر علامة مميزة + +381 +00:27:51,590 --> 00:27:53,730 +بعيد لـSedroblastic Anemia + +382 +00:27:56,460 --> 00:28:00,320 +طيب نيجي للـ Lab finding في الـ Sidroblastic + +383 +00:28:00,320 --> 00:28:04,720 +Anemia طبعا زي ما اتفقنا هيكون كل إشي قليل واطي + +384 +00:28:04,720 --> 00:28:08,040 +Microcytic Hypochromic Anemia الـ MCV الـ MCHC + +385 +00:28:08,040 --> 00:28:12,220 +الانيميا هتكون variable اللي هو reticulocyte count + +386 +00:28:12,220 --> 00:28:15,700 +لأن احنا اتفقنا هدول ال reticulocyte بيكون قليل + +387 +00:28:15,700 --> 00:28:19,420 +فيها ال iron deficiency و الحاجات اللي لها علاقة + +388 +00:28:19,420 --> 00:28:22,340 +بال nutritional مع ال Sidroblastic Anemia هتبتبت + +389 +00:28:22,340 --> 00:28:25,480 +تبقى reticulocyte قليلةاللي بيبقى فيه مشكلة في + +390 +00:28:25,480 --> 00:28:29,240 +تصنيع الـBlood نفسه الـHemoglobin والـRBCs طيب + +391 +00:28:29,240 --> 00:28:35,020 +RBCs Inclusions عادة ممكن أشوف بيزوفيليكستبلينج + +392 +00:28:35,020 --> 00:28:38,320 +أشهى الـBiophilic Stibling؟ هي بقايا ريبوزاما + +393 +00:28:38,320 --> 00:28:44,140 +الـRNA and ببنهاي مربادز اللي هي الـCedrocide ممكن + +394 +00:28:44,140 --> 00:28:49,300 +أشوف في بعض الأحيان Target Cells طيب بتتميز بإيش + +395 +00:28:49,300 --> 00:28:53,310 +هذه؟ نيجي لفحوصات الـSerumالـ Iron كيف هيكون؟ أكيد + +396 +00:28:53,310 --> 00:28:57,310 +هيكون عالي لأنه متراكم تمام؟ الـ Serum في الريتين + +397 +00:28:57,310 --> 00:29:00,290 +برضه عالي لكن الـ Total Iron Binding Capacity + +398 +00:29:00,290 --> 00:29:05,750 +هيكون Low ليش؟ لأن الـ Transferrin الموجود هيكون + +399 +00:29:05,750 --> 00:29:09,530 +مرتبط لأنه حديد كتير فبالتالي الـ Total Iron + +400 +00:29:09,530 --> 00:29:12,990 +Binding Capacity هي ببساطة قدرة الـ Transferrin + +401 +00:29:12,990 --> 00:29:17,590 +على ارتباط بالـ Ironطيب، decrease transferrin + +402 +00:29:17,590 --> 00:29:21,390 +synthesis occur in iron-overlaid states يعني هيكون + +403 +00:29:21,390 --> 00:29:28,170 +فيه برضه نقص في تصنيع الترانسفيرين وهذا بنعاكس في + +404 +00:29:28,170 --> 00:29:32,230 +الـ Total Iron Binding Capacity اللوه بون مارو + +405 +00:29:32,230 --> 00:29:35,150 +بشوف في الـ Ring Sidroblast ومرة تانية بقول + +406 +00:29:35,150 --> 00:29:37,950 +Hallmark of Sidroblastic Linia قلت لهم بجيبها + +407 +00:29:37,950 --> 00:29:39,190 +بالامتحان وما بتعرفوهاش + +408 +00:29:41,860 --> 00:29:46,600 +هنا عندنا شوية صور في عندى البابنهايمر body + +409 +00:29:46,600 --> 00:29:49,900 +بابنهايمر body زى ما انتوا شايفين عبارة عن زى + +410 +00:29:49,900 --> 00:29:53,740 +clusters بتكون في الخلية زى براد الحديد تجمعات من + +411 +00:29:53,740 --> 00:29:56,920 +الحديد هذا الـ cedroblast العادية انها شوف فيها + +412 +00:29:56,920 --> 00:30:00,920 +iron granules أما تزيد ال granules و تصير لها تجمع + +413 +00:30:00,920 --> 00:30:04,380 +حوالين النواء هذا بدل على انها cedroblastic anemia + +414 +00:30:04,380 --> 00:30:11,160 +هى عندى الصورة الحقيقية لها هى البابنهايمر bodyهي + +415 +00:30:11,160 --> 00:30:15,920 +الـ Cedroblast انه تجمع عادي للحديد حوالين الخلية + +416 +00:30:15,920 --> 00:30:19,460 +لكن لما يكون بهذا الشكل بقول هذه غالبا + +417 +00:30:19,460 --> 00:30:25,220 +Cedroblastic Anemia هاي عندنا مجموعة صور كمان هاي + +418 +00:30:25,220 --> 00:30:28,320 +هادي Mesophilic Stippling هادي Webbenheimer bodies + +419 +00:30:28,320 --> 00:30:34,000 +هادي برضه بس هنا varieties تانية بنات هنا + +420 +00:30:34,000 --> 00:30:36,600 +بالبروجياني blue stain علشان هيك ظهرت بهذا اللون + +421 +00:30:36,600 --> 00:30:43,620 +اللي هي ال Webbenheimer bodiesطيب البولمارو إيش + +422 +00:30:43,620 --> 00:30:47,760 +قلنا بنشوف فيه؟ بنشوف فيه ring cedroblast وبشوف + +423 +00:30:47,760 --> 00:30:53,760 +macro phages كبيرة مصبوغة بالمخ تصبغة الحديد ليش؟ + +424 +00:30:53,760 --> 00:30:56,280 +لأنه هتلاقي يعني البولمارو اللون بتاعه لما أصبغ + +425 +00:30:56,280 --> 00:30:59,780 +بليبروجيني blue ماخد أو مكتسح اللون الأزرق لأن + +426 +00:30:59,780 --> 00:31:05,580 +الحديد فيه بزيادة ثاني شيء لنوع آخر من أنواع + +427 +00:31:05,580 --> 00:31:08,780 +الانيميا اللي بتكون غالبا microcytic micro + +428 +00:31:08,780 --> 00:31:13,650 +hypochromicاللي هي Anemia of Chronic Disease هنا + +429 +00:31:13,650 --> 00:31:22,350 +Inability to use iron يعني الخلايا ما بتقدر تستخدم + +430 +00:31:22,350 --> 00:31:26,430 +الـ Iron لتصنيع الـ Hemoglobin وكمان بتحس .. يعني + +431 +00:31:26,430 --> 00:31:32,410 +بيصير في response للـ Erythrobiotin أقل طبعاً يعني + +432 +00:31:32,410 --> 00:31:36,230 +سبب شائع من أسباب الـ Anemia طيب، الحالات المرضية + +433 +00:31:36,230 --> 00:31:39,790 +اللي بشوف فيها Anemia زي Rheumatoid Arthritis + +434 +00:31:40,440 --> 00:31:44,540 +Chronic Renal Disease Thyroid Disease Malignancies + +435 +00:31:44,540 --> 00:31:49,200 +Tuberculosis Chronic Fungal Infection هذه حالات + +436 +00:31:49,200 --> 00:31:54,600 +مرضية شائعة في حدوث أنيميا Anemia of chronic + +437 +00:31:54,600 --> 00:31:57,960 +disease pathogenesis إيش اللي بيصير في الانيميا of + +438 +00:31:57,960 --> 00:32:02,220 +chronic disease؟ الانيميا of chronic disease عادة + +439 +00:32:02,220 --> 00:32:06,000 +يعني ممكن يصير فيها inflammation الinflammation + +440 +00:32:06,000 --> 00:32:08,940 +بصاحب مجموعة من خلايا المناعة بما فيها الـ + +441 +00:32:08,940 --> 00:32:13,480 +neutrophilلـ Neutrophil حبيباتها فيها مادة اسمها + +442 +00:32:13,480 --> 00:32:18,820 +الـ Lactoferrin تمام؟ الـ Lactoferrin هذا بيشبه أو + +443 +00:32:18,820 --> 00:32:23,280 +بينافس لـ Transferrin في عمله فبيروح و هو مرتبط + +444 +00:32:23,280 --> 00:32:27,200 +بالحديد و موديه لـ Macrophage بتاعة liver cell + +445 +00:32:27,200 --> 00:32:31,940 +بالتالي الجسم مش هيقدر يستفيد من الحديد اللي مرتبط + +446 +00:32:31,940 --> 00:32:35,740 +بالـ Lactoferrin نشوف Lactoferrin is an iron + +447 +00:32:35,740 --> 00:32:42,470 +binding proteinin the granules of neutrophil it is + +448 +00:32:42,470 --> 00:32:46,230 +ability for iron is greater than transferrin يعني + +449 +00:32:46,230 --> 00:32:49,490 +بيحب يرتبط بالiron أكتر مما بيفعل transferrin + +450 +00:32:49,490 --> 00:32:53,890 +during infection or inflammation neutrophil + +451 +00:32:53,890 --> 00:32:56,510 +lactoferrin released into plasma and hunt + +452 +00:32:56,510 --> 00:33:00,350 +available iron بروح هو مقتنظ ال iron الموجود ماسك + +453 +00:33:00,350 --> 00:33:04,590 +فيه؟ bind to macrophage هيرتبط مع ال macrophage + +454 +00:33:04,590 --> 00:33:09,820 +and liver cellsوبالتالي ليش؟ لأنه فيها receptor + +455 +00:33:09,820 --> 00:33:13,240 +لـLactoferrin فبالتالي احنا ما استفدنا من الحديد + +456 +00:33:13,240 --> 00:33:17,880 +وهذا طبعا من الأسباب الشائعة لحدوث أنيميا في هذا + +457 +00:33:17,880 --> 00:33:20,960 +السبب، في سبب تاني أنه في الـinflammatory disease + +458 +00:33:20,960 --> 00:33:23,620 +وفي الأمراض هذه بشكل عام تطلع الـcytokines + +459 +00:33:23,620 --> 00:33:28,260 +الـcytokines هذه بتنتج من الـmacrophages والخلايا + +460 +00:33:28,260 --> 00:33:33,940 +المناعة هذه عادة بتأثر على الـerythrobesis يعني + +461 +00:33:33,940 --> 00:33:39,440 +بتعملفي الـ Early Stage منها الـ Lab Finding نيجي + +462 +00:33:39,440 --> 00:33:42,300 +للـ Lab Diagnosis في الـ Early Stage بلاقي + +463 +00:33:42,300 --> 00:33:45,560 +الانيميا normocytic-normochromic بعدين بتبدأ تتطور + +464 +00:33:45,560 --> 00:33:50,140 +لhypochromic microcytic بلاقي leukocytosis لأن وضع + +465 +00:33:50,140 --> 00:33:53,280 +inflammation abundant storage of iron in + +466 +00:33:53,280 --> 00:33:57,280 +macrophage يعني في iron كتير ليش؟ لأن مافيش + +467 +00:33:57,280 --> 00:33:59,280 +استخدام جيد للـ iron + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY.srt new file mode 100644 index 0000000000000000000000000000000000000000..361abc18e0f876300202c0879e4e7608b873d9ce --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY.srt @@ -0,0 +1,1927 @@ +1 +00:00:01,690 --> 00:00:06,590 +بسم الله الرحمن الرحيم راح نبدأ مع بعض بإذن الله + +2 +00:00:06,590 --> 00:00:10,850 +في الجزئية الثانية من المادة اللي هي تتعلق بالـ + +3 +00:00:10,850 --> 00:00:18,130 +Leukemia بأنواعها وتصنيفها نواصل مع بعض في أنواع + +4 +00:00:18,130 --> 00:00:21,850 +الـ Acute Leukemia طبعا حكينا قبل هيك عن الـ Acute + +5 +00:00:21,850 --> 00:00:26,250 +Lymphoid Leukemia حكينا عن الـ classification لها + +6 +00:00:26,250 --> 00:00:30,410 +كاف الـ 1 و الـ 2 و الـ 3 الـ Acute Myeloid + +7 +00:00:30,410 --> 00:00:36,440 +Leukemia بتقسم على حسب الـ bone marrow blast + +8 +00:00:36,440 --> 00:00:40,000 +morphology حسب الـ predominant cell الموجودة في + +9 +00:00:40,000 --> 00:00:42,840 +الـ bone marrow الـ morphology اللي قيلها ال + +10 +00:00:42,840 --> 00:00:47,160 +degree of cell maturation حسب عند أي stage وقفت + +11 +00:00:47,160 --> 00:00:51,720 +الخلية cytochemical stains الـ immunophenotyping + +12 +00:00:52,280 --> 00:00:57,480 +ممكن أسميها Acute Granulocytic Leukemia بس المشهور + +13 +00:00:57,480 --> 00:01:01,140 +أكثر Acute Myeloid Leukemia طبعاً هي بتاخد تقسيمات + +14 +00:01:01,140 --> 00:01:05,240 +زي ما حكينا من M0 إلى M7 نيجي لتفاصيل الـ Acute + +15 +00:01:05,240 --> 00:01:09,700 +Myeloid Leukemia اللي هي Acute Non-Lymphoblastic + +16 +00:01:09,700 --> 00:01:15,000 +Leukemia أول حاجة هي زي ما قلنا من M0 إلى M7 هناخد + +17 +00:01:15,000 --> 00:01:19,950 +كل واحدة إيش خصائص الخلايا الموجودة فيها بدايةً نيجي + +18 +00:01:19,950 --> 00:01:25,530 +للـ M0 و M1 هدول الاثنتين يعني في تشابه بينهم عشان + +19 +00:01:25,530 --> 00:01:30,290 +هيك احنا بناخدهم من باب انه كيف نفرق بينهم أول شيء + +20 +00:01:30,290 --> 00:01:35,470 +الاثنتين هدول بلاقي فيهم Myeloblast لكن الـ M0 + +21 +00:01:35,470 --> 00:01:41,450 +بتكون الـ Myeloblast Early Myeloblast الـ M1 Late + +22 +00:01:41,450 --> 00:01:45,550 +Myeloblast طب إيش بتفرق الـ Early Myeloblast عن + +23 +00:01:45,550 --> 00:01:49,970 +الـ Late Myeloblast الـ Early Myeloblast بلاقي الـ + +24 +00:01:49,970 --> 00:01:54,010 +Myelobroxidase إنزايم فيها موجود بكمية ضئيلة جداً + +25 +00:01:54,010 --> 00:01:58,110 +Ultra Structural لدرجة إنه بالـ Myelobroxidase + +26 +00:01:58,110 --> 00:02:01,510 +Stain العادية الـ Cytochemical Stain بعتنيش + +27 +00:02:01,510 --> 00:02:07,210 +Positive إذا الـ M0 Myelobroxidase Negative MbO + +28 +00:02:07,210 --> 00:02:12,150 +Stain Negative الـ M1 هي برضه Myeloblast لكن في + +29 +00:02:12,150 --> 00:02:17,010 +مرحلة متقدمة متطورة أكثر من اللي موجودة في الـ M0 + +30 +00:02:17,560 --> 00:02:22,400 +هذه ممكن أشوف فيها بداية الـ Azorophilic granules + +31 +00:02:22,400 --> 00:02:26,820 +بشكل خفيف ممكن أشوف فيها الـ Myelobroxidase لو + +32 +00:02:26,820 --> 00:02:30,440 +عملته هذا هيعطيني Positive ممكن أشوف فيها الـ Auer rods + +33 +00:02:30,440 --> 00:02:34,600 +الـ Auer rods ما هي عبارة عن Azorophilic granules، صح؟ + +34 +00:02:34,600 --> 00:02:39,880 +فبالتالي الفرق بينهم في Myelobroxidase هنا هتلاقي + +35 +00:02:39,880 --> 00:02:43,680 +أن Myelobroxidase مع الـ maturation هتزيد ال + +36 +00:02:43,680 --> 00:02:47,180 +activity بتاعتها بدايةً هذا هتكون كميته قليلة جداً + +37 +00:02:47,180 --> 00:02:51,000 +ويعطيني بالـ cytokinical stain العادية Negative + +38 +00:02:51,000 --> 00:02:56,120 +بأكدها بالـ immunophenotype الـ M1 AML without + +39 +00:02:56,120 --> 00:02:59,200 +maturation إيش أصدوا without maturation يعني بس + +40 +00:02:59,200 --> 00:03:02,200 +بشوف فيها Blast هدول الاثنتين بشوف فيهم بس Blast + +41 +00:03:02,200 --> 00:03:07,700 +AML without maturation يعني ما بشوف في المراحل + +42 +00:03:07,700 --> 00:03:11,240 +التالية زي الـ Promyelocyte و الـ Myelocyte and so + +43 +00:03:11,240 --> 00:03:17,380 +on إيش مميزات الخلية؟ Monomorphic with one or more + +44 +00:03:17,380 --> 00:03:21,100 +distinct nuclei بشوف فيها نيوكليولاي Blast cell + +45 +00:03:21,100 --> 00:03:27,580 +occasional Auer rods and at least a 3% Myeloperoxidase + +46 +00:03:27,580 --> 00:03:34,620 +positive يعني هذه ممكن أميزها أن هذه بأورود + +47 +00:03:34,620 --> 00:03:37,620 +والميولوبروكسداز يعني إذا نجد الـ Auer rods معنى الكلام + +48 +00:03:37,620 --> 00:03:41,080 +هي M1 إذا أعطتني الميولوبروكسداز Positive غالبا هي + +49 +00:03:41,080 --> 00:03:41,840 +M1 + +50 +00:03:44,140 --> 00:03:51,160 +طيب نيجي لـ M2 M2 AML with maturation بشوف فيها + +51 +00:03:51,160 --> 00:03:54,200 +Blast خدوا بقى لكوا يا بنات بأكد هنا أنه احنا + +52 +00:03:54,200 --> 00:03:57,020 +بنحكي عن acute يعني في الـ bone marrow لازم الـ + +53 +00:03:57,020 --> 00:04:00,780 +blast يكون على الأقل 20% عشان أعتبرها Blast عشان + +54 +00:04:00,780 --> 00:04:08,110 +أعتبرها Acute طبعاً M2 AML with maturation يعني هنا + +55 +00:04:08,110 --> 00:04:12,410 +بلاقي Blast Cell بلاقي Myeloblast 50% أو أكثر + +56 +00:04:12,410 --> 00:04:16,850 +Myeloblast بلاقي Other Stages يعني هدول الاثنتين بس + +57 +00:04:16,850 --> 00:04:22,490 +Myeloblast لكن في هذه ممكن أشوف Promyelocyte ممكن + +58 +00:04:22,490 --> 00:04:26,810 +أشوف فيها أو الـ Auer rods ممكن أشوف فيها برضه يعني Other + +59 +00:04:26,810 --> 00:04:29,850 +Stages ممكن في بعض الحين أشوف Myeloblast وممكن + +60 +00:04:29,850 --> 00:04:34,350 +أشوف Myelocyte وممكن أشوف Metamyelocyte والمراحل + +61 +00:04:34,350 --> 00:04:38,300 +الـ Mature أكثر يعني إذا شفت فيه Maturation يعني + +62 +00:04:38,300 --> 00:04:43,340 +علامات الـ Maturation موجودة غالبا بتكون AML M2 + +63 +00:04:43,340 --> 00:04:48,740 +Dysplastic myeloid differentiation may be + +64 +00:04:48,740 --> 00:04:52,100 +present يعني أحيانا بتبقى لاقي فيه Dysplasia يعني + +65 +00:04:52,100 --> 00:04:55,440 +الخلايا الـ Maturation بتاعها مش طبيعي صح فيه + +66 +00:04:55,440 --> 00:04:58,420 +Maturation لكن فيه Abnormality في الـ Maturation في + +67 +00:04:58,420 --> 00:05:03,280 +أشكال الخلايا طيب نيجي للـ M3 هذه مشهورة من إنها + +68 +00:05:03,280 --> 00:05:10,040 +Acute Myelocytic Leukemia الخلية الشائعة هنا اللي + +69 +00:05:10,040 --> 00:05:13,160 +هي الـ Promyelocyte with heavy Azorophilic + +70 +00:05:13,160 --> 00:05:17,320 +granulation بلاقي فيها كمية كبيرة جدا من الـ + +71 +00:05:17,320 --> 00:05:21,380 +Azorophilic granules والـ granules تبقى فيها كبيرة + +72 +00:05:21,380 --> 00:05:26,920 +وواضحة ممكن اللي ألاقي فيها Auer rods بكمية كبيرة + +73 +00:05:26,920 --> 00:05:30,960 +وملحوظة لدرجة إنها بتعمل Auer rods bundles حزم من + +74 +00:05:30,960 --> 00:05:34,000 +الـ Auer rods وهذه بتعمل Confirmation للـ + +75 +00:05:34,000 --> 00:05:38,690 +diagnosis في Variant منها ممكن ألاقي الـ granules + +76 +00:05:38,690 --> 00:05:45,770 +فيها Small وثمينتها قليلة يعني الـ M3 Variant لكن + +77 +00:05:45,770 --> 00:05:48,990 +الـ Common اللي هي الـ Promyelocyte with heavy + +78 +00:05:48,990 --> 00:05:53,870 +granulation هذه بيسميها M3 نيجي للـ M4 Acute + +79 +00:05:53,870 --> 00:05:59,630 +Myelomonocytic هذه زي الـ M2 يعني بلاقي فيها + +80 +00:05:59,630 --> 00:06:04,910 +Myeloid مع الـ Maturation، آه لكن بلاقي كمان أكثر + +81 +00:06:04,910 --> 00:06:09,650 +من 20% Promonocyte and Monocyte يعني مش .. لا + +82 +00:06:09,650 --> 00:06:12,890 +تقتصر على الـ Myeloid cells اللي هي الـ Myeloblast + +83 +00:06:12,890 --> 00:06:15,450 +و الـ Promyelocyte و الـ Myelocyte و الـ + +84 +00:06:15,450 --> 00:06:18,810 +Metamyelocyte، لأ بلاقي فيها Other بلاقي فيها + +85 +00:06:18,810 --> 00:06:21,890 +Stages أخرى من الـ Monocytic Maturation عشان هي + +86 +00:06:21,890 --> 00:06:26,730 +قسمها Myelomonocytic يعني بلاقي فيها Myeloid + +87 +00:06:26,730 --> 00:06:31,940 +cells و بلاقي فيها Monocytic cells الـ M5 بتتميز + +88 +00:06:31,940 --> 00:06:38,760 +بإنها Monocytic طبعاً في منها two variant M5A + +89 +00:06:38,760 --> 00:06:44,240 +بلاقي 80% منها Monoblast is poorly differentiated + +90 +00:06:44,240 --> 00:06:49,280 +M5B بلاقي فيها 80% Monoblast Promonocyte or + +91 +00:06:49,280 --> 00:06:52,820 +Monocyte is well differentiated يعني بفرقوا عن بعض + +92 +00:06:52,820 --> 00:06:59,880 +إنه هذي بس بلاقي فيها Monoblast لكن الـ M5B بلاقي + +93 +00:06:59,880 --> 00:07:03,640 +فيها Other Maturation stage من الـ Monocytic + +94 +00:07:03,640 --> 00:07:06,720 +series بلاقي Monoblast, Promonocyte وممكن ألاقي + +95 +00:07:06,720 --> 00:07:14,300 +Monocyte الـ M6 Acute Erythrocytic Leukemia طبعا + +96 +00:07:14,300 --> 00:07:19,620 +بلاقي تقريبا أكثر من 50% من الـ Nucleated cells + +97 +00:07:19,620 --> 00:07:23,960 +with Multinucleated form and Cytoplasmic bridging + +98 +00:07:23,960 --> 00:07:29,990 +هنا بلاقي أن الخلية نفسها Dysplastic يعني شكلها مش + +99 +00:07:29,990 --> 00:07:36,510 +طبيعي بذر شاب شكلها مش منتظم بلاقي فيها Nucleus + +100 +00:07:36,510 --> 00:07:40,010 +أحيانا عاملة Multi-nucleation بلاقي الـ Cytoplasm + +101 +00:07:40,010 --> 00:07:43,430 +عامل بعض الـ Abnormalities الـ Myeloblast ممكن أشوف + +102 +00:07:43,430 --> 00:07:47,910 +فيها Myeloblast فوق الـ 30% إذن هذه الخلايا اللي + +103 +00:07:47,910 --> 00:07:51,490 +قلنا عنها Dysplastic Nucleated Red Cells أصلها + +104 +00:07:51,490 --> 00:07:54,970 +Erythroid عشان هي أصلها اسمها Acute Erythrocytic + +105 +00:07:54,970 --> 00:08:00,580 +Leukemia الـ M7 Megakaryoblastic Anemia هذه عادة + +106 +00:08:00,580 --> 00:08:04,260 +بلاقي Heterogeneous Blast Population with + +107 +00:08:04,260 --> 00:08:08,700 +Cytoplasmic Clefts اللي هي بتاعة الـ Megakaryoblast + +108 +00:08:08,700 --> 00:08:14,420 +الخلية Megakaryoblast تتميز بأنها خلية كبيرة فيها + +109 +00:08:14,420 --> 00:08:19,720 +نتوءات طالعة من الـ Cytoplasm على شكل حبيبات زي + +110 +00:08:19,720 --> 00:08:25,940 +الزوائد يعني طبعاً هذه بتعطيني Platelet Peroxidase + +111 +00:08:25,940 --> 00:08:35,500 +Positive هذه Acute Megakaryocytic Leukemia طيب + +112 +00:08:35,500 --> 00:08:39,580 +نيجي عليهم يعني من ناحية Morphology نشوفهم أول + +113 +00:08:39,580 --> 00:08:44,060 +حاجة الـ M1 الـ M1 زي ما قلت لكم Myeloblast without + +114 +00:08:44,060 --> 00:08:46,620 +Maturation يعني بشوف في الـ Blood Film بس + +115 +00:08:46,620 --> 00:08:50,410 +Myeloblast وهذا الـ Film لو أنا شفته في بعض الأحيان + +116 +00:08:50,410 --> 00:08:54,490 +ممكن أقول M0 أو M1 طب إيش اللي بيخليني أقول M0 أو + +117 +00:08:54,490 --> 00:08:59,490 +M1؟ وجود الـ Auer rods هنا بيقول إنها M1 مش M0 لو مش + +118 +00:08:59,490 --> 00:09:02,710 +موجود الـ Auer rods لازمني أعمل Myeloperoxidase إذا + +119 +00:09:02,710 --> 00:09:06,090 +طلعت Positive غالبا بتكون M1 إذا طلعت Negative + +120 +00:09:06,090 --> 00:09:11,710 +بتكون M0 The Bomber هلاقي فيه أكثر من 90% Blast + +121 +00:09:11,710 --> 00:09:16,670 +and less than 10% Promyelocyte يعني الـ Most Common + +122 +00:09:16,670 --> 00:09:26,560 +اللي هي المشكلة بتحصل في الكبار أكثر منها في الأصغر + +123 +00:09:26,560 --> 00:09:36,060 +سناً هاي الـ Auer rods واضح في الخلايا شايفينه هذه + +124 +00:09:36,060 --> 00:09:42,540 +العصية الصغيرة طيب + +125 +00:09:42,540 --> 00:09:45,700 +نيجي للـ AML M2 + +126 +00:09:47,840 --> 00:09:52,800 +myeloplastic with maturation قلنا هذه بلاقي فيها + +127 +00:09:52,800 --> 00:09:56,520 +myeloblast myelocyte myelocyte myelocyte myelocyte + +128 +00:09:56,520 --> 00:09:58,200 +myelocyte myelocyte myelocyte myelocyte myelocyte + +129 +00:09:58,200 --> 00:09:58,400 +myelocyte myelocyte myelocyte myelocyte myelocyte + +130 +00:09:58,400 --> 00:10:00,060 +myelocyte myelocyte myelocyte myelocyte myelocyte + +131 +00:10:00,060 --> 00:10:00,940 +myelocyte myelocyte myelocyte myelocyte myelocyte + +132 +00:10:00,940 --> 00:10:01,520 +myelocyte myelocyte myelocyte myelocyte myelocyte + +133 +00:10:01,520 --> 00:10:03,620 +myelocyte myelocyte myelocyte myelocyte myelocyte + +134 +00:10:03,620 --> 00:10:04,660 +myelocyte myelocyte myelocyte myelocyte myelocyte + +135 +00:10:04,660 --> 00:10:06,580 +myelocyte myelocyte myelocyte myelocyte myelocyte + +136 +00:10:06,580 --> 00:10:12,160 +myelocyte myelocyte + +137 +00:10:15,450 --> 00:10:19,550 +فيها كروموسوم الـ Translocation ما بين ثمانية و واحد + +138 +00:10:19,550 --> 00:10:23,770 +و عشرين كروموسوم ثمانية و كروموسوم واحد و عشرين زي ما + +139 +00:10:23,770 --> 00:10:31,490 +أنتم شايفين فينا Blast Cells تمام و فينا mature + +140 +00:10:31,490 --> 00:10:35,110 +neutrophil Hypogranulated Polymorphonuclear + +141 +00:10:35,110 --> 00:10:38,370 +Leukocytes يعني فيها Hypogranulation فهذه من + +142 +00:10:38,370 --> 00:10:40,470 +علامات الـ Dysplastic Maturation + +143 +00:10:45,250 --> 00:10:49,310 +This occurs in older adults برضه بتفصل في الكبار + +144 +00:10:49,310 --> 00:10:55,850 +أكثر منها في الصغار طيب + +145 +00:10:55,850 --> 00:11:03,330 +نيجي لـ M3، M3 قلنا فيها هي اللي فيها الـ + +146 +00:11:03,330 --> 00:11:07,210 +hypergranular والـ hypogranular، الـ hypergranular + +147 +00:11:07,210 --> 00:11:10,990 +برومييلوسيتك سلز طبعا هي بتتميز بوجود + +148 +00:11:10,990 --> 00:11:17,360 +البرومييلوسيت، بلاقي البون مارو في أكثر من 30% + +149 +00:11:17,360 --> 00:11:24,180 +بلازما، تعتبر من الأنواع الـ virulent ليش؟ لأنه لما + +150 +00:11:24,180 --> 00:11:28,820 +بياخد المريض العلاج بتبقى الخلايا تحت اللوكيميا + +151 +00:11:28,820 --> 00:11:31,800 +هذه الـ helibroma helicid يصير الـ helices أو + +152 +00:11:31,800 --> 00:11:35,480 +يصيرها destruction، الخلايا هذه فيها حبيبات + +153 +00:11:35,480 --> 00:11:41,550 +الحبيبات هذه فيها مواد بتعمل coagulation and بتبعوا + +154 +00:11:41,550 --> 00:11:44,550 +fibrinolysis، يعني بتشجع عملية الـ coagulation and + +155 +00:11:44,550 --> 00:11:48,030 +fibrinolysis، وطبعا هذه تؤدي يعني بتنشط الـ + +156 +00:11:48,030 --> 00:11:51,210 +coagulation والـ fibrinolysis، هذا بيؤدي لإيش؟ لـ + +157 +00:11:51,210 --> 00:11:54,810 +disseminated intravascular coagulation، فعادة + +158 +00:11:54,810 --> 00:11:58,530 +بيتبعوا هذا bleeding، وبتكون الـ prognosis سيئة على + +159 +00:11:58,530 --> 00:12:06,410 +المريض، عادة بتحصل في عمر متوسط 39 سنة، بتتميز هذه بـ + +160 +00:12:06,410 --> 00:12:09,770 +Translocation 15 إلى 17 بـ chromosomal + +161 +00:12:09,770 --> 00:12:15,050 +translocation، هذه الخلايا الـ Promyelocyte فيها + +162 +00:12:15,050 --> 00:12:20,290 +أزوروفيليك جرانيول زي ما أنتم شايفين هيها، والـ + +163 +00:12:20,290 --> 00:12:25,090 +granules فيها كتير واضحة، طيب نيجي للنوع الثاني + +164 +00:12:25,090 --> 00:12:28,170 +اللي هو الـ Hypogranular Promyelocyte leukemia + +165 +00:12:28,170 --> 00:12:33,630 +بتتميز بوجود Promyelocyte بس الـ Promyelocyte هذه + +166 +00:12:34,110 --> 00:12:39,910 +hypogranular يعني الـ granules فيها قليلة وبتشكل + +167 +00:12:39,910 --> 00:12:42,950 +الـ blast فيها تلاقي أكثر من 30% في الـ bone marrow + +168 +00:12:42,950 --> 00:12:47,670 +نفس الشيء ممكن العلاج يتسبب بالـ DIC وفيها + +169 +00:12:47,670 --> 00:12:54,370 +translocation 15-17 chromosomal translocation، هاي + +170 +00:12:54,370 --> 00:13:01,070 +الخلايا Promyelocyte بس الـ granules عيطها fine، M4 + +171 +00:13:01,070 --> 00:13:07,710 +AML M4، م4 زي ما حكينا هي acute myelomonocytic + +172 +00:13:07,710 --> 00:13:12,990 +leukemia، acute myelomonocytic يعني فيها myeloid + +173 +00:13:12,990 --> 00:13:19,790 +precursors و monocytic precursors، طبعا هذه الـ + +174 +00:13:19,790 --> 00:13:22,610 +precursors بشوفها سواء في الـ bone marrow أو في + +175 +00:13:22,610 --> 00:13:28,530 +الـ peripheral blood، دايما لما يكون في الـ leukemia + +176 +00:13:28,530 --> 00:13:33,430 +monocytic precursors، هذه الـ Monocytic Precursors + +177 +00:13:33,430 --> 00:13:37,410 +لها القدرة على إنها تعمل Infiltration في الـ body + +178 +00:13:37,410 --> 00:13:41,470 +تشوف في أماكن خارج Extra Medullary Sites، يعني ممكن + +179 +00:13:41,470 --> 00:13:45,890 +تعمل Infiltration في أماكن مختلفة من الجسم أكثر من + +180 +00:13:45,890 --> 00:13:48,950 +اللي هي الـ Granulocytic Types، تشوفين الـ + +181 +00:13:48,950 --> 00:13:53,610 +Monocytic Precursors موجودة هنا بشكل واضح + +182 +00:13:53,610 --> 00:13:58,710 +Monoblast، هدول Monoblast وهدول اللي فيهم fissure + +183 +00:13:58,710 --> 00:14:03,820 +Pro Monocytes، الـ M5 طبعا بتتميز بإنها acute + +184 +00:14:03,820 --> 00:14:09,260 +monocytic leukemia، أكثر من 80% من الـ non + +185 +00:14:09,260 --> 00:14:12,800 +-erythroid cells عبارة عن monocytic و monocytic + +186 +00:14:12,800 --> 00:14:13,640 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +187 +00:14:13,640 --> 00:14:13,980 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +188 +00:14:13,980 --> 00:14:14,540 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +189 +00:14:14,540 --> 00:14:14,620 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +190 +00:14:14,620 --> 00:14:14,760 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +191 +00:14:14,760 --> 00:14:23,340 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +192 +00:14:23,340 --> 00:14:26,980 +«مونوبلاستيك» «م + +193 +00:14:30,680 --> 00:14:34,500 +This form is further divided into تنقسم إلى + +194 +00:14:34,500 --> 00:14:42,540 +نوعين، M5A و M5B، M5A عبارة عن purely differentiated + +195 +00:14:42,540 --> 00:14:47,760 +leukemia، كيف يعني؟ هلاقي أكثر من 80% من الخلايا + +196 +00:14:47,760 --> 00:14:54,220 +monoblast، M5B والـ differentiated الـ 80% هدول + +197 +00:14:54,220 --> 00:15:00,060 +هتلاقي منهم monoblast، promonocyte، و monocyte، تمام؟ + +198 +00:15:04,410 --> 00:15:09,890 +هنا M5A أعتقد يعني هذه لأن اللي موجودين بس Blast + +199 +00:15:09,890 --> 00:15:14,810 +اعتبرت M5A، ليش؟ عندي other stages من الـ Monocyte + +200 +00:15:14,810 --> 00:15:22,250 +التي رزقها هذه M5B، لأن موجود فيها Monoblast، موجود + +201 +00:15:22,250 --> 00:15:28,830 +فيها Promonocyte، عشان أحط المؤشر بس، موجود فيها + +202 +00:15:28,830 --> 00:15:33,970 +Monoblast، موجود فيها Promonocyte، hybromonocyte اللي + +203 +00:15:33,970 --> 00:15:37,230 +بتتميز بوجود single fissure في الخلية، موجود فيها + +204 +00:15:37,230 --> 00:15:42,230 +mature monocyte، علشان هيك بنعتبرها M5B، الـ M6 + +205 +00:15:42,230 --> 00:15:47,370 +طبعا بيسميها Erythroleukemia لأن بتتميز بإن الـ + +206 +00:15:47,370 --> 00:15:49,890 +erythroblast بتلاقيها predominant في الـ bone + +207 +00:15:49,890 --> 00:15:53,770 +marrow، وزي ما قلت لكم الخلايا بتلاقيها dysplastic + +208 +00:15:53,770 --> 00:15:58,110 +يعني في abnormality في الـ maturation، الخلايا شوفوا + +209 +00:15:58,110 --> 00:16:01,630 +كيف إن هو يعني فيها segmentation، طبعا هذه حاجة + +210 +00:16:01,630 --> 00:16:07,150 +abnormal، طبعا إلها ثلاث مراحل من ناحية الـ + +211 +00:16:07,150 --> 00:16:09,950 +Morphology، المرحلة الأولى إني بلاقي Abnormal + +212 +00:16:09,950 --> 00:16:13,770 +Normoblast موجودة بكمية كبيرة، هذه المرحلة الأولى + +213 +00:16:13,770 --> 00:16:18,750 +المرحلة الثانية Erythroleukemia، هيصير زيادة في الـ + +214 +00:16:18,750 --> 00:16:23,290 +Erythroblast والـ Myeloblast، ممكن تتطور للمرحلة + +215 +00:16:23,290 --> 00:16:26,390 +الثالثة إنها تتحول لـ Myeloblastic Leukemia، تتصير + +216 +00:16:26,390 --> 00:16:32,570 +M1 أو M2 أو M4، تمام؟ هذه هي المراحل بتاعة الـ M6 + +217 +00:16:33,480 --> 00:16:37,420 +طبعا شايفين فيها الأنيميا لأن هي أساسا بتضرب الـ + +218 +00:16:37,420 --> 00:16:40,360 +Erythroid precursors، شايفين كلها هذه Erythroid + +219 +00:16:40,360 --> 00:16:47,380 +precursors، الـ + +220 +00:16:47,380 --> 00:16:53,300 +M7، طبعا الـ M7 بتتميز بإنها acute megakaryoblastic + +221 +00:16:53,300 --> 00:16:58,420 +leukemia، عبارة عن rare disorder بتتميز بـ extensive + +222 +00:16:58,420 --> 00:17:03,530 +proliferation of megakaryoblast اللي هي موجود برضه a + +223 +00:17:03,530 --> 00:17:09,030 +typical megakaryocyte and thrombocytopenia، الخليط + +224 +00:17:09,030 --> 00:17:13,830 +الـ Megakaryoblast هذه هي بتتميز بأن الـ cytoplasm + +225 +00:17:13,830 --> 00:17:17,570 +بتاعها قليل وغامق كتير وفيه نتوءات أو بروزات على + +226 +00:17:17,570 --> 00:17:26,050 +شكل plebs موجودة حوالين الخلية يعني + +227 +00:17:26,050 --> 00:17:31,650 +جزئية الـ cytochemistry، الأصباف الأساسية اللي + +228 +00:17:31,650 --> 00:17:34,390 +بنستخدمها الـ Special Stains اللي بنستخدمها عشان + +229 +00:17:34,390 --> 00:17:37,850 +نميز بين أنواع اللوكيميا زي ما قلنا إن اللوكيميا + +230 +00:17:37,850 --> 00:17:41,450 +لازم أستخدم لها Special Stains عشان أتميز عند + +231 +00:17:41,450 --> 00:17:44,970 +الخلايا عن بعض لأن أحيانا كتير الـ Blast بيكون + +232 +00:17:44,970 --> 00:17:48,690 +صعب جدا أفصل يعني أفصلها، بيبقى تشابه كتير كتير + +233 +00:17:48,690 --> 00:17:51,950 +فيها خاصة في حالات اللوكيميا فبيكون من الصعوبة + +234 +00:17:51,950 --> 00:17:54,510 +بمكان أني أفصلها عن بعض عشان هيك أنا بستخدم + +235 +00:17:54,510 --> 00:17:57,430 +Special Stain أو اللي بسميه Cytochemistry + +236 +00:17:58,010 --> 00:18:01,410 +Cytochemistry لأن التفاعل الكيميائي بيصير في داخل + +237 +00:18:01,410 --> 00:18:09,990 +الخلية، طيب بداية بدي أفصل الـ AML عن الـ ALL أستخدم + +238 +00:18:09,990 --> 00:18:12,990 +الـ myeloperoxidase، أحنا عارفين إن الـ myeloid + +239 +00:18:12,990 --> 00:18:16,590 +والـ monocytic precursors، هأخدوا بالكم، الـ myeloid + +240 +00:18:16,590 --> 00:18:19,890 +والـ monocytic بتحتوي على الـ myeloperoxidase + +241 +00:18:19,890 --> 00:18:23,390 +فبالتالي هتعطيني positive بينما الـ lymphoid + +242 +00:18:23,390 --> 00:18:29,740 +هتعطيني negative، تمام؟ واللي بيعمل يعني واللي بيدعم + +243 +00:18:29,740 --> 00:18:32,420 +هذه الصبغة أو بيأكدها أو بيعمل لها confirmation + +244 +00:18:32,420 --> 00:18:35,980 +برضه هي إن تطلع معايا نتائج مش كتير واضحة بالـ + +245 +00:18:35,980 --> 00:18:40,060 +Myeloperoxidase أو يعني في شك فيها، ممكن أؤكد نتيجتي + +246 +00:18:40,060 --> 00:18:43,080 +بالـ Sudan Black، Sudan Black بيعطيني نفس نتائج + +247 +00:18:43,080 --> 00:18:47,800 +Myeloperoxidase، بيعطيني في الـ AML positive وفي الـ + +248 +00:18:47,800 --> 00:18:52,160 +ALL بيعطيني negative، تمام؟ إذا نرجع تاني + +249 +00:18:52,160 --> 00:18:57,070 +Myeloperoxidase تعطيني positive في الـ acute Myeloid + +250 +00:18:57,070 --> 00:19:00,350 +Leukemia يعني بالـ Myeloid Cell وبالـ Monocytic + +251 +00:19:00,350 --> 00:19:04,110 +Cell بينما في الـ Myeloperoxidase بتعطيني Negative طيب في + +252 +00:19:04,110 --> 00:19:08,490 +حالة الـ Myeloperoxidase بتعطيني فيها Negative في + +253 +00:19:08,490 --> 00:19:13,490 +الـ AML إيش هي قلناها اللي هي الـ M0 لأن لسه + +254 +00:19:13,490 --> 00:19:17,010 +الأنزيم بيكونش متكون لدرجة إنه يقدر يعطيني + +255 +00:19:17,010 --> 00:19:20,270 +Positive Reaction Visible أقدر أشوفه فبالتالي الـ + +256 +00:19:20,270 --> 00:19:25,720 +M0 هتعطيني AML Negative و ALL Negative هذه الملاحظة + +257 +00:19:25,720 --> 00:19:31,020 +مهمة الـ MPO روح تعطيني في التنتين negative طيب، + +258 +00:19:31,020 --> 00:19:35,960 +الآن احنا فصلنا إذا كانت مثلا acute myeloid والـ + +259 +00:19:35,960 --> 00:19:39,960 +acute lymphocytic leukemia طبعا، بس ما فصلنا الـ + +260 +00:19:39,960 --> 00:19:42,920 +myeloid عن الـ monocyte بنيجي بالـ non-specific + +261 +00:19:42,920 --> 00:19:47,380 +stress الـ non-specific stress بتفصل ليه؟الـ + +262 +00:19:47,380 --> 00:19:51,620 +Myeloid بتعطيني Negative Non-specific stress بينما + +263 +00:19:51,620 --> 00:19:55,200 +الـ Monocytic اللي هي فيها M4 و M5 فيها Monocytic + +264 +00:19:55,200 --> 00:19:59,940 +cells هتعطيكي Non-specific stress Positive تمام؟ + +265 +00:19:59,940 --> 00:20:04,000 +إذن الـ Non-specific stress فصلي الـ Myeloid عن + +266 +00:20:04,000 --> 00:20:06,280 +الـ Monocytic الـ Monocytic بتعطيني Positive + +267 +00:20:06,280 --> 00:20:09,200 +الـ Myeloid في الـ Non-specific stress بتعطيني + +268 +00:20:09,200 --> 00:20:15,140 +بتعطيني Negative طيب بعد هيك بنيجي للـ BAS الـ BAS + +269 +00:20:16,990 --> 00:20:21,790 +الـ BAS عادة بتعطيني positive في الـ lymphoid الـ + +270 +00:20:21,790 --> 00:20:24,450 +common أن الـ BAS بتعطيني positive في الـ lymphoid + +271 +00:20:24,450 --> 00:20:30,510 +بالإضافة للـ M6 من الـ myeloid تعطيني يعني للـ + +272 +00:20:30,510 --> 00:20:32,970 +lymphoid precursor و للـ erythroid precursor + +273 +00:20:32,970 --> 00:20:39,270 +بتعطيني positive لـ M6 و لـ ALL طيب نيجي للـ acid + +274 +00:20:39,270 --> 00:20:44,410 +phosphatase الـ acid phosphatase عادة بيعطيني في + +275 +00:20:44,410 --> 00:20:49,370 +الـ AML negative وفي الـ ALL في الـ T cell acute + +276 +00:20:49,370 --> 00:20:53,730 +lymphocytic leukemia هيعطيكي positive اللي هو مين؟ + +277 +00:20:53,730 --> 00:20:56,450 +الـ acid phosphatase إذا كنتوا فاكرين أكثر حاجة + +278 +00:20:56,450 --> 00:21:00,450 +استخدمناها للفصل أو تمييز الـ Hairy cell leukemia + +279 +00:21:00,450 --> 00:21:05,550 +الـ Hairy cell leukemia طيب acute lymphoblastic leukemia + +280 +00:21:05,550 --> 00:21:10,550 +reactivity with specialists تمام؟ هلاقيت الـ L1 + +281 +00:21:10,550 --> 00:21:14,940 +تعطيني بالـ peroxidase أو Sudan black negative الـ + +282 +00:21:14,940 --> 00:21:18,920 +Non-specific stress نيجاتيف الـ BAS positive زي ما + +283 +00:21:18,920 --> 00:21:23,400 +قلنا الـ BAS بالمفايد بتعطيني positive الـ + +284 +00:21:23,400 --> 00:21:27,780 +L2 نفس الأشياء و L3 نفس الأشياء لكن هنا في + +285 +00:21:27,780 --> 00:21:32,040 +عندي exception بدنا ناخد بالنا منه يعني هو هنا الـ + +286 +00:21:32,040 --> 00:21:36,560 +peroxidase و Sudan black ماشي طبقنا عليهم هم بس + +287 +00:21:36,560 --> 00:21:41,260 +هنا في exception للـ Sudan black الـ L3 بتتميز + +288 +00:21:41,260 --> 00:21:43,920 +الخلايا بتاعتها إنها Vacuolated إذا كنتوا فاكرين + +289 +00:21:44,200 --> 00:21:46,940 +وقلنا إيش سبب الـ Vacuoles سبب الـ Vacuoles يعني + +290 +00:21:46,940 --> 00:21:51,280 +إنه فيه fat في قلب الخلية ولما أنا بحط الكحول للـ + +291 +00:21:51,280 --> 00:21:55,080 +fixation بتدوب الـ fat هذه وبتترك مكانها فجوات الـ + +292 +00:21:55,080 --> 00:21:59,900 +Sudan black صبغة مخصصة لصبغ الـ fat فبالتالي + +293 +00:21:59,900 --> 00:22:03,800 +أكيد هتعطيني positive مع الـ L3 ليش؟ لأن الخلية + +294 +00:22:03,800 --> 00:22:06,700 +فيها fat فبالتالي يعتبر الـ Sudan black هنا + +295 +00:22:06,700 --> 00:22:10,420 +exception لـ L1 و L3 لأنه يعطي معاها + +296 +00:22:10,420 --> 00:22:13,810 +positive تمام؟ exception الوحيد اللي هو Sudan + +297 +00:22:13,810 --> 00:22:23,690 +black positive في الـ L3 بأكتب عن نقطة هذه نيجي + +298 +00:22:23,690 --> 00:22:27,770 +للـ Immunophenotyping الـ Immunophenotyping + +299 +00:22:27,770 --> 00:22:32,030 +بيستخدم بشكل يعني أكثر وبشكل أساسي للتمييز بين + +300 +00:22:32,030 --> 00:22:37,390 +أنواع الـ B والـ T لمفوسايت والدرجة الـ Maturation + +301 +00:22:37,390 --> 00:22:42,070 +لها الـ A بالنسبة للخلايا أو الـ بتعتمد على + +302 +00:22:42,070 --> 00:22:46,770 +إيش؟ أن الخلايا خلال الـ Maturation لها بتتميز + +303 +00:22:46,770 --> 00:22:49,270 +عليها الـ CDs اللي هي الـ Clusters of + +304 +00:22:49,270 --> 00:22:53,530 +Differentiation طبعا هذه كل مرحلة من مراحل الـ + +305 +00:22:53,530 --> 00:22:58,010 +Maturation بتاع الخلية بتميز وجود CDs مختلفة عن + +306 +00:22:58,010 --> 00:23:01,710 +المرحلة اللي قبلها فمن خلال معرفتنا لنوع الـ CD + +307 +00:23:01,710 --> 00:23:05,290 +الموجود على سطح الخلية نقدر نعرف أي Stage من + +308 +00:23:05,290 --> 00:23:10,850 +الخلية وصلت لهالـ إيش؟ لأن الـ … يعني ممكن بتلاحظوا + +309 +00:23:10,850 --> 00:23:14,770 +في الـ … في الـ Lymphocytic Maturation مافيش عندي + +310 +00:23:14,770 --> 00:23:18,670 +هالـ Morphological Changes اللي ممكن ألاحظها زي + +311 +00:23:18,670 --> 00:23:21,670 +الـ Myeloid الـ Myeloid كنا نقدر نميز كثير الـ + +312 +00:23:21,670 --> 00:23:24,730 +Myeloblast عن الـ Promyelocyte عن الـ لكن الـ + +313 +00:23:24,730 --> 00:23:28,250 +Lymphocyte من Lymphoblast و Promyelocyte الـ + +314 +00:23:28,250 --> 00:23:31,850 +mature lymphocyte كثير في تقارب بالـ بالـ + +315 +00:23:31,850 --> 00:23:34,950 +Morphology لها فاحنا بدنا نلجأ لطريقة أخرى + +316 +00:23:34,950 --> 00:23:39,740 +للتمييز وطبعا طريقة دقيقة وبتحدد عندي في أي مرحلة + +317 +00:23:39,740 --> 00:23:43,160 +أو بتحدد عندي في أي مرحلة الخلية من الـ Maturation + +318 +00:23:43,160 --> 00:23:48,480 +الـ بتعتمد على أن أنا بدور على CD معين مثلا Body + +319 +00:23:48,480 --> 00:23:52,800 +Flow Labeled Antibody بـ Fluorescence إذا كان مرتبط + +320 +00:23:52,800 --> 00:23:55,840 +الخلية بهذا Labeled Antibody طبعا فيه Direct و + +321 +00:23:55,840 --> 00:23:58,600 +Indirect هحكيهم بالـ Slide اللي بعدها عشان في + +322 +00:23:58,600 --> 00:24:02,700 +رسمة بالتوضيح هحكيهم بالتفصيل لكن أنا بشكل أساسي + +323 +00:24:02,700 --> 00:24:05,820 +بدور على Marker معين بضيف له Antibody labelled ب + +324 +00:24:05,820 --> 00:24:10,240 +Fluorescence إذا ارتبط فيه، هيعطيني واميد الآن + +325 +00:24:10,240 --> 00:24:15,620 +بمرر الخلايا هذه على الـ Flow Cytometer فهيعد + +326 +00:24:15,620 --> 00:24:19,280 +الخلايا اللي هي labelled بالـ Fluorescence ويحدد + +327 +00:24:19,280 --> 00:24:22,400 +مين الخلايا الـ Positive لهذا الـ Marker ومين + +328 +00:24:22,400 --> 00:24:26,040 +الخلايا الـ Negative بالنسبة للـ Principle، هشرحها + +329 +00:24:26,040 --> 00:24:31,220 +في الـ Slide ده في عندي Direct أو Indirect Labeling + +330 +00:24:31,220 --> 00:24:35,500 +للـ Antigen يعني أنا بدي أتخيل عندي هذه الخلية + +331 +00:24:35,500 --> 00:24:41,800 +عليها يعني Marker معين أنا بدور عليه بشوف هل الـ + +332 +00:24:41,800 --> 00:24:45,580 +Marker هذا موجود ولا لأ بجيب له Antibody و بربطه + +333 +00:24:45,580 --> 00:24:50,260 +فيه في عندي طريقتين للشغل في طريقة Indirect اني + +334 +00:24:50,260 --> 00:24:56,100 +أنا مباشرة بجيب Antibody labelled بـ Fluorescence خاص + +335 +00:24:56,100 --> 00:25:01,840 +بهذا الـ Antigen و بربطه فيه طبعا إذا كان ارتبط + +336 +00:25:01,840 --> 00:25:06,320 +خلاص بعد هيك بعمل Washing عشان أغزل الـ Excess من + +337 +00:25:06,320 --> 00:25:09,500 +هذا الـ Antibody الزيادة من هذا الـ Antibody بدي + +338 +00:25:09,500 --> 00:25:13,700 +أغسلها عشان ما تعملش عندي خلال في القراءة فإيش + +339 +00:25:13,700 --> 00:25:17,380 +اللي بيضل عندي؟ هيضل عندي كل الخلايا المرتبطة بالـ + +340 +00:25:17,380 --> 00:25:20,400 +Antibody labelled وبتم عدها من خلال جهاز + +341 +00:25:20,400 --> 00:25:25,100 +Flow Cytometer هذه الطريقة إيش؟ Direct سميناها + +342 +00:25:25,100 --> 00:25:28,050 +Direct لأن الـ Antibody اللي أنا استخدمته Directly + +343 +00:25:28,050 --> 00:25:31,390 +ارتبط بالـ Antigen الطريقة الثانية اللي هي + +344 +00:25:31,390 --> 00:25:35,870 +Indirect بيكون في عندي Two Antibodies واحد فيهم + +345 +00:25:35,870 --> 00:25:41,150 +بيرتبط مباشرة بالـ Antigen اللي أنا بدور عليه أو + +346 +00:25:41,150 --> 00:25:46,510 +الـ Marker اللي أنا بدور عليه الآن بيكون في عندي + +347 +00:25:46,510 --> 00:25:53,830 +Antibody للـ FC portion للـ Antibody الأولاني يعني + +348 +00:25:53,830 --> 00:25:56,650 +في عندي Primary Antibody ارتبط و الـ Secondary + +349 +00:25:56,650 --> 00:25:59,690 +Antibody راح يرتبط بالـ Primary طب فإيش هيرتبط؟ + +350 +00:25:59,690 --> 00:26:05,770 +هيرتبط بالـ FC portion الآن الـ Second Antibody هو + +351 +00:26:05,770 --> 00:26:11,070 +اللي labelled الـ Second Antibody هو اللي labelled فالآن + +352 +00:26:11,070 --> 00:26:16,670 +بعمل Washing بعمل بعد الـ Washing يعني طبعا بشيل أي + +353 +00:26:16,670 --> 00:26:20,570 +Antibody مرتبطش يعني عندي Washing أولاني بعمله في + +354 +00:26:20,570 --> 00:26:26,160 +المرحلة هذه بشيل عندي أي Primary Antibody مرتبطش + +355 +00:26:26,160 --> 00:26:29,840 +بيبقى عندي مين اللي مرتبط الـ Primary Antibody مع + +356 +00:26:29,840 --> 00:26:31,560 +الـ Antigen هو اللي بيبقى عندي في الـ Reaction + +357 +00:26:31,560 --> 00:26:36,760 +Mixture الآن باضيف الـ Labelled Antibody Labelled + +358 +00:26:36,760 --> 00:26:40,560 +Antibody هيرتبط مع الـ Antibody اللي كان مرتبط على + +359 +00:26:40,560 --> 00:26:44,560 +سطح الخلية ويتكون عندي هذا الـ Complex الـ Complex + +360 +00:26:44,560 --> 00:26:48,640 +هذا هيمر على جهاز الـ Flow Cytometer ويقرأ الـ + +361 +00:26:48,640 --> 00:26:53,310 +Fluorescence له الآن برضه قبل ما أمرره الخطوة + +362 +00:26:53,310 --> 00:26:56,570 +الأخيرة لازم أعمل Washing عشان أتخلص من أي + +363 +00:26:56,570 --> 00:26:59,830 +Labelled Unbound Antibody يعني هنا في عملية + +364 +00:26:59,830 --> 00:27:03,170 +Washing مرتين أتخلص من الـ Antibody الـ Unbound في + +365 +00:27:03,170 --> 00:27:06,370 +المرحلة الأولى و أتخلص من الـ Antibody الـ Unbound + +366 +00:27:06,370 --> 00:27:10,330 +في المرحلة الثانية طبعا هنا سميناها Indirect لأن + +367 +00:27:10,330 --> 00:27:14,200 +كان في Antibody المرتبط مباشرة بالـ Antigen أنا + +368 +00:27:14,200 --> 00:27:17,400 +قصدت الـ Antibody المرتبط بالـ Antibody الـ Primary + +369 +00:27:17,400 --> 00:27:20,560 +الـ Secondary Antibody اللي تم قياسه مش الـ Primary + +370 +00:27:20,560 --> 00:27:25,200 +Antibody هيك بنكون عرفنا كيف الارتباط بيكون + +371 +00:27:25,200 --> 00:27:30,460 +Direct أو Indirect نيجي + +372 +00:27:30,460 --> 00:27:37,220 +للـ TdT اللي هو Terminal Deoxynucleotidyl Transferase هذا + +373 +00:27:37,220 --> 00:27:43,410 +عبارة عن DNA Polymerase يكون موجود في الـ B و الـ T + +374 +00:27:43,410 --> 00:27:46,590 +precursors في الـ Lymphoid precursors يعني في الـ + +375 +00:27:46,590 --> 00:27:52,610 +Stem cells عادة بلاقي بـ High levels في تقريبا 90% + +376 +00:27:52,610 --> 00:27:57,370 +% من حالات الـ lymphoblastic leukemia ممكن أحدده + +377 +00:27:57,370 --> 00:28:00,930 +باستخدام برضه labelled antibody وباستخدام الـ flow + +378 +00:28:00,930 --> 00:28:03,610 +cytometry زي ما حكينا طوي عن الـ cluster of + +379 +00:28:03,610 --> 00:28:08,510 +differentiation عدّي هفرزلكم جداول ونُميز الخلايا + +380 +00:28:08,510 --> 00:28:11,990 +من خلال أشياء معينة في الشرائح القادمة هيكون + +381 +00:28:11,990 --> 00:28:14,570 +الموضوع أوضح بشكل واحد طيب، نيجي إلى + +382 +00:28:14,570 --> 00:28:18,510 +الـClassification بناء على الـ Cell Markers الـAML + +383 +00:28:18,510 --> 00:28:23,250 +والـALL حناخد أول إشي الـAML الـAML بتتميز غالبا + +384 +00:28:23,250 --> 00:28:27,850 +بوجود الـCD13 و33 هدول الاتنين بيكونوا positive + +385 +00:28:27,850 --> 00:28:33,350 +فيها بينما الـTDT negative ليش؟ لأنها لأنه بيكون + +386 +00:28:33,350 --> 00:28:35,850 +positive في الـ lymphoid precursors ما بيكون في + +387 +00:28:35,850 --> 00:28:40,090 +الـ myeloid precursors الآن نيجي لحاجات خاصة يعني + +388 +00:28:40,090 --> 00:28:43,570 +مثلا الـ M6 بلاقي فيها الـ glycophorin A positive + +389 +00:28:43,570 --> 00:28:51,510 +تمام الـ M7 بلاقي فيها الـ CD41 و 42 و 61 positive + +390 +00:28:51,510 --> 00:28:58,090 +اللي هي الـ acute megakaryoplastic leukemia هنا + +391 +00:28:58,780 --> 00:29:05,700 +بتم يعني الـ ALL في منها Precursor B ALL في عندي B + +392 +00:29:05,700 --> 00:29:11,720 +ALL وفي عندي T Acute Lymphoblastic Leukemia طبعا + +393 +00:29:11,720 --> 00:29:15,040 +الـ Markers اللي بدنا نصنف بناء عليها اللي هي CD + +394 +00:29:15,040 --> 00:29:22,200 +CD19, 22, TDT, 10 Intracytoplasmic chains Surface + +395 +00:29:22,200 --> 00:29:29,210 +Immunoglobulin CD7, CD3 والـ Morphology related to + +396 +00:29:29,210 --> 00:29:35,150 +which type الـ 1 أو الـ 2 أو الـ 3 أول حاجة لـ + +397 +00:29:35,150 --> 00:29:40,010 +Precursor B ALL في منها تلت أنواع نوع بيسموه + +398 +00:29:40,010 --> 00:29:46,650 +Common ALL Common ALL بتلاقي الـ 19 و 22 و الـ TDT + +399 +00:29:46,650 --> 00:29:51,490 +و العشرة positive تمام؟ الـ Null type بتفرق عنها + +400 +00:29:51,490 --> 00:29:55,820 +إن العشرة فيها negative CD10 فيها negative لمّا + +401 +00:29:55,820 --> 00:29:59,600 +بيكون مش مكتوب حاجة يعني حاجة مش مميزة يعني لا + +402 +00:29:59,600 --> 00:30:02,780 +بقدر أقول ممكن تكون positive أو negative مش بشكل + +403 +00:30:02,780 --> 00:30:05,360 +منتظم يعني مش دايما positive ومش دايما negative + +404 +00:30:05,360 --> 00:30:07,860 +فبالتالي لمّا المنطقة الضباطية هذه اللي ماعليهاش + +405 +00:30:07,860 --> 00:30:11,580 +positive أو negative يعني لا تستخدم في التمييز أو + +406 +00:30:11,580 --> 00:30:16,550 +في تحديد هذه الأنواع من الـ Locateالـ Pre-B cell + +407 +00:30:16,550 --> 00:30:22,430 +الـ Pre-B cell هلاقيهم تقريبا متشابهة الـ CD10 + +408 +00:30:22,430 --> 00:30:25,170 +variable ممكن يبقى positive أو negative إيش بزيد + +409 +00:30:25,170 --> 00:30:28,950 +عليها؟ الـ Intra-cytoplasmic chain إيش هي الـ + +410 +00:30:28,950 --> 00:30:31,490 +Intra-cytoplasmic chain؟ الـ Intra-cytoplasmic + +411 +00:30:31,490 --> 00:30:36,290 +chain هو عبارة عن الـ surface immunoglobulin وهو + +412 +00:30:36,290 --> 00:30:39,370 +عمال بتصنع في داخل الـ cytoplasm يعني هو لسه ما + +413 +00:30:39,370 --> 00:30:42,990 +طلعت على فتح الخلية هنا بلاقي في الـ Pre-B cell + +414 +00:30:42,990 --> 00:30:48,440 +positive بعدين بيجي عند الـ قولنا الـ precursor + +415 +00:30:48,440 --> 00:30:52,540 +قسمناها لتلاتة بتيجي عند الـ BALL وبتيجي عند الـ + +416 +00:30:52,540 --> 00:30:59,000 +TALL الـ BALL طبعا الـ CD10 فيها negative والـ + +417 +00:30:59,000 --> 00:31:03,380 +surface immunoglobulin negative الـ TALL فيها الـ + +418 +00:31:03,380 --> 00:31:11,400 +CD10 positive هلقيت الـ null type ممكن تكون L1 أو + +419 +00:31:11,400 --> 00:31:17,600 +L2 طبعا common ممكن تكون أي نوع الـ Null Type قلنا + +420 +00:31:17,600 --> 00:31:23,900 +L1 أو L2 الـ Pre-B برضه قد تكون L1 أو L2 الـ BALL + +421 +00:31:23,900 --> 00:31:32,220 +غالباً L3 الـ TALL TALL قلتلكم الـ CD10 فيها بتكون + +422 +00:31:32,220 --> 00:31:38,560 +Positive تتميز الـ T بالـ CD7 والـ CD3 فدول اتنين + +423 +00:31:38,560 --> 00:31:43,240 +بيكونوا Positive وممكن تكون على شكل L1 أو L2 ماشي + +424 +00:31:43,240 --> 00:31:45,820 +يعني على شكل الخلايا ماخدة الـ Criteria + +425 +00:31:45,820 --> 00:31:55,700 +المورفولوجي تاعة الـ L1 أو الـ L2 طيب + +426 +00:31:55,700 --> 00:31:58,580 +نيجي إلى الـ Classification هل هي B أو T + +427 +00:31:58,580 --> 00:32:03,240 +-Lymphocyte؟ يعني بناء على الـ Markers معينة هنشوف + +428 +00:32:03,240 --> 00:32:07,880 +إذا كانت B Lineage أو T الـ B بتشكل 80% والـ T + +429 +00:32:07,880 --> 00:32:13,130 +بتشكل 20% الـ Markers اللي هنفصل من خلالها الـ B + +430 +00:32:13,130 --> 00:32:18,310 +عادة الـ TdT بتكون فيها positive فكل ما تخلية M + +431 +00:32:18,310 --> 00:32:21,670 +mature بتكون فيها الـ TdT positive يعني في عندي في + +432 +00:32:21,670 --> 00:32:27,410 +الـ Bra B وفي عندي Common وفي عندي Pre-B يعني الـ + +433 +00:32:27,410 --> 00:32:31,530 +Bra B مرحل السابق للـ Pre-B بعدين ال mature B + +434 +00:32:31,530 --> 00:32:35,750 +هتلاقي فيهم الـ TdT positive بس في ال mature هتصير + +435 +00:32:35,750 --> 00:32:39,310 +negative لأن مع ال matureation هتلاقيها بلشات + +436 +00:32:39,310 --> 00:32:44,500 +تختفي الـ Cd19 هتلاقيها positive في كل الـB + +437 +00:32:44,500 --> 00:32:50,280 +الـCD10 positive ما عدا في الـBra B الـSurface + +438 +00:32:50,280 --> 00:32:56,040 +immunoglobulin هو احنا المفروض نقول الـCytoplasmic + +439 +00:32:56,040 --> 00:33:00,360 +immunoglobulin لأنه بظهر في مراحل الـSurface يعني + +440 +00:33:00,360 --> 00:33:04,360 +هو أول شي بظهر في الـCytoplasmic على سطح الخلية + +441 +00:33:04,360 --> 00:33:07,920 +فبالتالي الـCytoplasmic ممكن نلاقيه في الـPre-B + +442 +00:33:07,920 --> 00:33:12,850 +وفي الـMature B تمام؟ بعد هيك في الـ Surface + +443 +00:33:12,850 --> 00:33:16,350 +Immunoglobulin هتلاقيه بس في الـ Mature B لأن كل + +444 +00:33:16,350 --> 00:33:19,770 +الـ Cytoplasmic طلع على سطح الخلية وصار على شكل + +445 +00:33:19,770 --> 00:33:25,010 +Surface Immunoglobulin طيب نيجي للـ T الـ T عادة + +446 +00:33:25,010 --> 00:33:28,590 +بتتميز بالـ CD7 إنها positive والـ TDT برضه + +447 +00:33:28,590 --> 00:33:35,870 +positive طبعاً في عند الـ Pre-T و Mature-T الـ CD2 + +448 +00:33:35,870 --> 00:33:39,270 +بيفرق أن الـ Pre-T بيبقى فيها Negative والـ Mature + +449 +00:33:39,270 --> 00:33:43,350 +-T بيكون فيها Positive طبعاً هذا بالزمن في ال + +450 +00:33:43,350 --> 00:33:45,870 +classification لنوع الـ acute lymphoblastic + +451 +00:33:45,870 --> 00:33:52,870 +leukemia اللي هي B أو T lymphoblast حطيت هذه + +452 +00:33:52,870 --> 00:33:56,210 +الصورة بس عشان يعني تاخدوا فكرة إيش اللي بيصير + +453 +00:33:56,210 --> 00:33:59,970 +فعلياً هي الـ Maturation بتاع الـ B-cell قلتلكم الـ + +454 +00:33:59,970 --> 00:34:02,510 +Maturation الشكل تقريبا متشابه جدا في الـ + +455 +00:34:02,510 --> 00:34:05,490 +lymphocyte maturation فبنميز من خلال الـ markers + +456 +00:34:05,490 --> 00:34:09,350 +كل مرحلة معينة من مراحل الـ maturation تتميز ب + +457 +00:34:09,350 --> 00:34:11,790 +markers معينة يعني في ال early stages بتلاقي + +458 +00:34:11,790 --> 00:34:15,830 +الـTDT positive لكن بعد هيك بتبدأ الـTDT بتختفي في + +459 +00:34:15,830 --> 00:34:21,750 +ال mature الـHLA-DR والـCD19 بتكون positive على + +460 +00:34:21,750 --> 00:34:25,830 +طول للآخر الـCD20 في مرحلة معينة بتظهر وبعدين + +461 +00:34:25,830 --> 00:34:29,950 +بتختفي الـ CD10 برضه نفس الأشي في مراحل بتكون + +462 +00:34:29,950 --> 00:34:33,910 +موجودة فيها المراحل بتكونش الـ immunoglobulin برضه + +463 +00:34:33,910 --> 00:34:38,210 +ممكن تكون موجودة مع الـ maturation بتبدأ تظهر على + +464 +00:34:38,210 --> 00:34:41,730 +سطح الخلية، تمام؟ هي صورة تانية للـ B cell + +465 +00:34:41,730 --> 00:34:45,530 +maturation هذه بس صور توضحية يعني هي الـ + +466 +00:34:45,530 --> 00:34:49,090 +progenerator cell الخلية الأولى هتلاقي فيها الـ + +467 +00:34:49,090 --> 00:34:52,610 +TdT positive اللي بعدها اللي بعدها بعد هيك الـ TdT + +468 +00:34:52,610 --> 00:34:57,010 +بطل positive طيب، نيجي للـ Markers مثلا هذه بتتميز + +469 +00:34:57,010 --> 00:35:04,030 +بالـ CD 3419 هذه 3419 و 10 TDT هذه هتلاقي في عندك + +470 +00:35:04,030 --> 00:35:07,630 +TDT positive زي ما قلنا اللي هي الـ Pre-B cell + +471 +00:35:07,630 --> 00:35:13,670 +فيها 19 و 10 و 20 و 22 يعني الشاهد في الموضوع أن + +472 +00:35:13,670 --> 00:35:17,630 +كل مرحلة من المراحل هذه بتتميز بـ Markers خاصة + +473 +00:35:17,630 --> 00:35:20,510 +فيها الـ Chronic Lymphocytic Leukemia و الـ Pro + +474 +00:35:20,510 --> 00:35:23,440 +-Lymphocytic Leukemia برضه إلها Markers الـ Hair + +475 +00:35:23,440 --> 00:35:26,700 +Cell Leukemia برضه إلها Markers الـ Wild Storm + +476 +00:35:26,700 --> 00:35:32,140 +Heavy Chain Disease برضه إله Markers معينة الملطب + +477 +00:35:32,140 --> 00:35:36,800 +الميلومة إلها Markers معينة هيك بتتمييز الـ B Cell + +478 +00:35:36,800 --> 00:35:41,440 +Leukemia من خلال الـ Immunophenotyping عشان نعرف + +479 +00:35:41,440 --> 00:35:45,220 +أي Stage اللي هي عاملة الخلية فيها Proliferation + +480 +00:35:45,220 --> 00:35:52,670 +الـ T Cell نفس الإشي برضه كل مرحلة من المراحل بتاعة + +481 +00:35:52,670 --> 00:35:56,590 +الـ Maturation للـ T cell هتلاقي إلها Markers خاصة + +482 +00:35:56,590 --> 00:35:57,030 +فيها diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..c7eee6efbea9bc7d5226085619bfd0231e1b1682 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY_postprocess.srt @@ -0,0 +1,1928 @@ +1 +00:00:01,690 --> 00:00:06,590 +بسم الله الرحمن الرحيم راح نبدأ مع بعض بإذن الله + +2 +00:00:06,590 --> 00:00:10,850 +في الجزئية التانية من المادة اللي هي تتعلق بالـ + +3 +00:00:10,850 --> 00:00:18,130 +Leukemia بأنواعها وتصنيفها نواصل مع بعض في أنواع + +4 +00:00:18,130 --> 00:00:21,850 +الـ Acute Leukemia طبعا حكينا قبل هيك عن الـ Acute + +5 +00:00:21,850 --> 00:00:26,250 +Lymphoid Leukemia حكينا عن ال classification لإلها + +6 +00:00:26,250 --> 00:00:30,410 +كاف الـ 1 و الـ 2 و الـ 3 الـ Acute Myeloid + +7 +00:00:30,410 --> 00:00:36,440 +Leukemiaبتقسم على حسب الـ bone marrow blast + +8 +00:00:36,440 --> 00:00:40,000 +morphology حسب الـ predominant cell الموجودة في + +9 +00:00:40,000 --> 00:00:42,840 +الـ bone marrow الـ morphology اللي قيلها ال + +10 +00:00:42,840 --> 00:00:47,160 +degree of cell maturation حسب عند أي stage وقفة + +11 +00:00:47,160 --> 00:00:51,720 +الخلية cytochemical stains الـ immunophenotyping + +12 +00:00:52,280 --> 00:00:57,480 +ممكن أسميها Acute Granulocytic Leukemia بس المشهور + +13 +00:00:57,480 --> 00:01:01,140 +أكتر Acute Myeloid Leukemia طبعاً هي بتاخد تقسيمات + +14 +00:01:01,140 --> 00:01:05,240 +زي ما حكينا من M0 إلى M7 نيجي لتفاصيل الـ Acute + +15 +00:01:05,240 --> 00:01:09,700 +Myeloid Leukemia اللي هي Acute Non-Lymphoblastic + +16 +00:01:09,700 --> 00:01:15,000 +Leukemia أول حاجة هي زي ما قلنا من M0 إلى M7 هناخد + +17 +00:01:15,000 --> 00:01:19,950 +كل واحدة إيش خصائص الخلايا الموجودة فيها بدايةنيجي + +18 +00:01:19,950 --> 00:01:25,530 +للـ M0 و M1 هدول التنتين يعني في تشابه بينهم عشان + +19 +00:01:25,530 --> 00:01:30,290 +هيك احنا بناخدهم من باب انه كيف نفرق بينهم أول شئ + +20 +00:01:30,290 --> 00:01:35,470 +التنتين هدول بلاقي فيهم Myeloblast لكن الـ M0 + +21 +00:01:35,470 --> 00:01:41,450 +بتكون الـ Myeloblast Early Myeloblast الـ M1 Late + +22 +00:01:41,450 --> 00:01:45,550 +Myeloblast طب إيش بتفرق الـ Early Myeloblast عن + +23 +00:01:45,550 --> 00:01:49,970 +الـ Late Myeloblast الـ Early Myeloblastبلاقي الـ + +24 +00:01:49,970 --> 00:01:54,010 +Myelobroxidase إنزايم فيها موجود بكمية ضئيلة جدًا + +25 +00:01:54,010 --> 00:01:58,110 +Ultra Structural لدرجة إنه بالـ Myelobroxidase + +26 +00:01:58,110 --> 00:02:01,510 +Stain العادية الـ Cytochemical Stain بعتنيش + +27 +00:02:01,510 --> 00:02:07,210 +Positive إذا الـ M0 MbO Negative Myelobroxidase + +28 +00:02:07,210 --> 00:02:12,150 +Stain Negative الـ M1 هي برضه Myeloblast لكن في + +29 +00:02:12,150 --> 00:02:17,010 +مرحلة متقدمة متطورة أكتر من اللي موجودة في الـ M0 + +30 +00:02:17,560 --> 00:02:22,400 +هذه ممكن أشوف فيها بداية الـ Azorophilic granules + +31 +00:02:22,400 --> 00:02:26,820 +بشكل خفيف ممكن أشوف فيها الـ Myelobroxidase لو + +32 +00:02:26,820 --> 00:02:30,440 +عملته هذا هيعطيني positive ممكن أشوف فيها الأول رد + +33 +00:02:30,440 --> 00:02:34,600 +الأول رد ما هي عبارة عن Azorophilic granules، صح؟ + +34 +00:02:34,600 --> 00:02:39,880 +فبالتالي الفرق بينهم في Myelobroxidase هنا هتلاقي + +35 +00:02:39,880 --> 00:02:43,680 +أن Myelobroxidase مع الـ maturation هتزيد ال + +36 +00:02:43,680 --> 00:02:47,180 +activity بتاعتهفدايةً هذا هتكون كميته قليلة جداً + +37 +00:02:47,180 --> 00:02:51,000 +ويعطيني بالـ cytokinical stain العادية negative + +38 +00:02:51,000 --> 00:02:56,120 +بأكدها بالـ immunophenotype الـ M1 AML without + +39 +00:02:56,120 --> 00:02:59,200 +maturation إيش أصدوا without maturation يعني بس + +40 +00:02:59,200 --> 00:03:02,200 +بشوف فيها blast هدول الفنتان بشوف فيهم بس blast + +41 +00:03:02,200 --> 00:03:07,700 +AML without maturation يعني ما بشوف في المراحل + +42 +00:03:07,700 --> 00:03:11,240 +التالية زي الـ Bromelocyte و الـ Myelocyte and so + +43 +00:03:11,240 --> 00:03:17,380 +onإيش مميزات الخلية؟ Monomorphic with one or more + +44 +00:03:17,380 --> 00:03:21,100 +distinct nuclei بشوف فيها نيوكليولاي Blast cell + +45 +00:03:21,100 --> 00:03:27,580 +occasional أورود and at least a 3% ميولوبروكسداز + +46 +00:03:27,580 --> 00:03:34,620 +positive يعني هذه ممكن أميزها أن هذه بأورود + +47 +00:03:34,620 --> 00:03:37,620 +والميولوبروكسداز يعني إذا نجد الأورود معنى الكلام + +48 +00:03:37,620 --> 00:03:41,080 +هي M1 إذا أعطتني الميولوبروكسداز positive غالبا هي + +49 +00:03:41,080 --> 00:03:41,840 +M + +50 +00:03:44,140 --> 00:03:51,160 +طيب نجي لـ M2 M2 AML with maturation بشوف فيها + +51 +00:03:51,160 --> 00:03:54,200 +Blast خدوا بقى لكوا يا بناة بأكد هنا أنه احنا + +52 +00:03:54,200 --> 00:03:57,020 +بنحكي عن acute يعني في الـ bone marrow لازم الـ + +53 +00:03:57,020 --> 00:04:00,780 +blast يكون على الأقل 20% عشان أعتبرها blast عشان + +54 +00:04:00,780 --> 00:04:08,110 +أعتبرها acute طبعاً M2 AML with maturation يعنيهنا + +55 +00:04:08,110 --> 00:04:12,410 +بلاقي Blast Cell بلاقي Myeloblast 50% أو أكتر + +56 +00:04:12,410 --> 00:04:16,850 +Myeloblast بلاقي Other Stages يعني هدول التنتين بس + +57 +00:04:16,850 --> 00:04:22,490 +Myeloblast لكن في هذه ممكن أشوف Raw Myelocyte ممكن + +58 +00:04:22,490 --> 00:04:26,810 +أشوف فيها أو الرد ممكن أشوف فيها برضه يعني Other + +59 +00:04:26,810 --> 00:04:29,850 +Stages ممكن في بعض الحين أشوف Myeloblast وممكن + +60 +00:04:29,850 --> 00:04:34,350 +أشوف Myelocyte وممكن أشوف Metamyelocyte والمراحل + +61 +00:04:34,350 --> 00:04:38,300 +ال mature أكتر يعني إذا شفتفيه maturation يعني + +62 +00:04:38,300 --> 00:04:43,340 +علامات الـ maturation موجودة غالبا بتكون AML M2 + +63 +00:04:43,340 --> 00:04:48,740 +this plastic myeloid differentiation may be + +64 +00:04:48,740 --> 00:04:52,100 +present يعني أحيانا بتبقى لاقي فيه dysplasia يعني + +65 +00:04:52,100 --> 00:04:55,440 +الخلايا ال maturation بتاعها مش طبيعي صح فيه + +66 +00:04:55,440 --> 00:04:58,420 +maturation لكن فيه abnormality في ال maturation في + +67 +00:04:58,420 --> 00:05:03,280 +أشكال الخلايا طيب نجي للـ M3 هذه مشهورة من إنها + +68 +00:05:03,280 --> 00:05:10,040 +acutemyelocytic leukemia الخلية الشائعة هنا اللي + +69 +00:05:10,040 --> 00:05:13,160 +هي الـ Bromielocyte with heavy azorophilic + +70 +00:05:13,160 --> 00:05:17,320 +granulation بلاقي فيها كمية كبيرة جدا من الـ + +71 +00:05:17,320 --> 00:05:21,380 +azorophilic granules والـ granules تبقى فيها كبيرة + +72 +00:05:21,380 --> 00:05:26,920 +وواضحة ممكن اللي ألاقي فيها our roots بكمية كبيرة + +73 +00:05:26,920 --> 00:05:30,960 +وملحوظة لدرجة إنها بتعمل our root bundles حزم من + +74 +00:05:30,960 --> 00:05:34,000 +الـ our roots وهذه بتعمل confirmation للـ + +75 +00:05:34,000 --> 00:05:38,690 +diagnosisفي variant منها ممكن ألاقي الـ granules + +76 +00:05:38,690 --> 00:05:45,770 +فيها small وثمينتها قليلة يعني الـ M3 variant لكن + +77 +00:05:45,770 --> 00:05:48,990 +ال common اللي هي الـ raw myelocyte with heavy + +78 +00:05:48,990 --> 00:05:53,870 +granulation هذه بيسميها M3 نيجي للـ M4 acute + +79 +00:05:53,870 --> 00:05:59,630 +myelomonocytic هذه زي الـ M2 يعني بلاقي فيها + +80 +00:05:59,630 --> 00:06:04,910 +myeloidمع الـ Maturation، آه لكن بلاقي كمان أكتر + +81 +00:06:04,910 --> 00:06:09,650 +من 20% Bromonocyte and Monocyte يعني مش .. لا + +82 +00:06:09,650 --> 00:06:12,890 +تقتصر على الـ Myeloid cells اللي هي الـ Myeloblast + +83 +00:06:12,890 --> 00:06:15,450 +و الـ Bromyelocyte و الـ Myelocyte و الـ + +84 +00:06:15,450 --> 00:06:18,810 +Metamyelocyte، لأ بلاقي فيها Other بلاقي فيها + +85 +00:06:18,810 --> 00:06:21,890 +Stages أخرى من الـ Monocytic Maturation عشان هي + +86 +00:06:21,890 --> 00:06:26,730 +قسمها قطيوت Myelomonocytic يعني بلاقي فيها Myeloid + +87 +00:06:26,730 --> 00:06:31,940 +cells و بلاقي فيها Monocytic cellsالـ M5 بتتميز + +88 +00:06:31,940 --> 00:06:38,760 +بإنها monocytic طبعاً في منها two variant M5A + +89 +00:06:38,760 --> 00:06:44,240 +بلاقي 80% منها monoblast is poorly differentiated + +90 +00:06:44,240 --> 00:06:49,280 +M5B بلاقي فيها 80% monoblast pro monocyte or + +91 +00:06:49,280 --> 00:06:52,820 +monocyte is well differentiated يعني بفرقوا عن بعض + +92 +00:06:52,820 --> 00:06:59,880 +إنه هذي بس بلاقي فيها monoblast لكن الـ5P بلاقي + +93 +00:06:59,880 --> 00:07:03,640 +فيها other maturation stage من الـ monocytic + +94 +00:07:03,640 --> 00:07:06,720 +series بلاقي monoplast, promonocyte وممكن ألاقي + +95 +00:07:06,720 --> 00:07:14,300 +monocyte الـ M6 acute erythrocytic leukemia طبعا + +96 +00:07:14,300 --> 00:07:19,620 +بلاقي تقريبا أكتر من 50% من الـ nucleated cells + +97 +00:07:19,620 --> 00:07:23,960 +with multinucleated form and cytoplasmic bridging + +98 +00:07:23,960 --> 00:07:29,990 +هنا بلاقي أن الخلية نفسهاDisplastic يعني شكلها مش + +99 +00:07:29,990 --> 00:07:36,510 +طبيعي بذر شاب شكلها مش منتظم بلاقي فيها nucleus + +100 +00:07:36,510 --> 00:07:40,010 +أحيانا عاملة multi-nucleation بلاقي الـ cytoplasm + +101 +00:07:40,010 --> 00:07:43,430 +عامل بعض الـ abnormalities المييلو بلاست ممكن أشوف + +102 +00:07:43,430 --> 00:07:47,910 +فيها مييلو بلاست فوق الـ 30% إذن هذه الخلايا اللي + +103 +00:07:47,910 --> 00:07:51,490 +قلنا عنها Displastic nucleated red cells أصلها + +104 +00:07:51,490 --> 00:07:54,970 +Erythroid عشان هي أجه اسمها acute erythrocytic + +105 +00:07:54,970 --> 00:08:00,580 +leukemiaالـ M7 ميجالو بلاستيك أنيميا هذه عادة + +106 +00:08:00,580 --> 00:08:04,260 +بلائق heterogeneous blast population with + +107 +00:08:04,260 --> 00:08:08,700 +cytoplasmic clips اللي هي بتاعة الـ Megakaryoblast + +108 +00:08:08,700 --> 00:08:14,420 +الخلية ميجا كاريو بلاست تميز بأنها خلية كبيرة فيها + +109 +00:08:14,420 --> 00:08:19,720 +نتوءات طالعة من الـ cytoplasm على شكل حبيبات زي + +110 +00:08:19,720 --> 00:08:25,940 +الزوائد يعنيطبعاً هذه بتعطيني platelet peroxidase + +111 +00:08:25,940 --> 00:08:35,500 +positive هذه acute megakaryocytic leukemia طيب + +112 +00:08:35,500 --> 00:08:39,580 +نيجي عليهم يعني من ناحية morphology نشوفهم أول + +113 +00:08:39,580 --> 00:08:44,060 +حاجة ال M1 ال M1 زي ما قلتلكم myeloblast without + +114 +00:08:44,060 --> 00:08:46,620 +maturation يعني بشوف في ال blood film بس + +115 +00:08:46,620 --> 00:08:50,410 +myeloblastوهذا الفيلم لو أنا شفته في بعض الأحيان + +116 +00:08:50,410 --> 00:08:54,490 +ممكن أقول M0 أو M1 طب إيش اللي بيخليني أقول M0 أو + +117 +00:08:54,490 --> 00:08:59,490 +M1؟ وجود الأول رد هنا بيقول إنها M1 مش M0 لو مش + +118 +00:08:59,490 --> 00:09:02,710 +موجود الأول رد لازمني أعمل Myeloperoxidase إذا + +119 +00:09:02,710 --> 00:09:06,090 +طلعت positive غالبا بتكون M1 إذا طلعت negative + +120 +00:09:06,090 --> 00:09:11,710 +بتكون M0 The Bomber هلاقي فيه أكتر من 90% blast + +121 +00:09:11,710 --> 00:09:16,670 +and less than 10% bromielocyte يعني ال most common + +122 +00:09:16,670 --> 00:09:26,560 +اللي هيالمشكلة تحصل في الكبار أكثر منها في الأصغر + +123 +00:09:26,560 --> 00:09:36,060 +سناً هاي الأول رد واضح في الخلايا شايفينه هذه + +124 +00:09:36,060 --> 00:09:42,540 +العصية الصغيرة طيب + +125 +00:09:42,540 --> 00:09:45,700 +نيجي لل AML M2 + +126 +00:09:47,840 --> 00:09:52,800 +myeloplastic with maturation قلنا هذه بلاقي فيها + +127 +00:09:52,800 --> 00:09:56,520 +myeloplast myelocyte myelocyte myelocyte myelocyte + +128 +00:09:56,520 --> 00:09:58,200 +myelocyte myelocyte myelocyte myelocyte myelocyte + +129 +00:09:58,200 --> 00:09:58,400 +myelocyte myelocyte myelocyte myelocyte myelocyte + +130 +00:09:58,400 --> 00:10:00,060 +myelocyte myelocyte myelocyte myelocyte myelocyte + +131 +00:10:00,060 --> 00:10:00,940 +myelocyte myelocyte myelocyte myelocyte myelocyte + +132 +00:10:00,940 --> 00:10:01,520 +myelocyte myelocyte myelocyte myelocyte myelocyte + +133 +00:10:01,520 --> 00:10:03,620 +myelocyte myelocyte myelocyte myelocyte myelocyte + +134 +00:10:03,620 --> 00:10:04,660 +myelocyte myelocyte myelocyte myelocyte myelocyte + +135 +00:10:04,660 --> 00:10:06,580 +myelocyte myelocyte myelocyte myelocyte myelocyte + +136 +00:10:06,580 --> 00:10:12,160 +myelocyte myelocyte + +137 +00:10:15,450 --> 00:10:19,550 +فيها كرمزوم الـ Translocation ما بين تمانية و واحد + +138 +00:10:19,550 --> 00:10:23,770 +و عشرين كرمزوم تمانية و كرمزوم واحد و عشرين زي ما + +139 +00:10:23,770 --> 00:10:31,490 +انتوا شايفين فينا Blast Cells تمام و فينا mature + +140 +00:10:31,490 --> 00:10:35,110 +neutrophil Hypogranulated Polymorphon Nuclear + +141 +00:10:35,110 --> 00:10:38,370 +Leukocytes يعني فيها Hypogranulation فهذه من + +142 +00:10:38,370 --> 00:10:40,470 +علامات الـ Displastic Maturation + +143 +00:10:45,250 --> 00:10:49,310 +This occurs in older adults برضه بتفصل في الكبار + +144 +00:10:49,310 --> 00:10:55,850 +أكتر منها في الصغار طيب + +145 +00:10:55,850 --> 00:11:03,330 +نيجي لـ M3 M3 قلنا فيها هي اللي فيها الـ + +146 +00:11:03,330 --> 00:11:07,210 +hypergranular و الـ hypogranular الـ hypergranular + +147 +00:11:07,210 --> 00:11:10,990 +براومييلوسيتك سلز طبعا هي بتتميز بوجود + +148 +00:11:10,990 --> 00:11:17,360 +البراومييلوسيتبلاقي البون مارو في أكتر من 30% + +149 +00:11:17,360 --> 00:11:24,180 +بلازد تعتبر من الأنواع الـ virulent ليش؟ لأنه لما + +150 +00:11:24,180 --> 00:11:28,820 +بياخد المريض العلاج بتبقى الخلايا تحت اللوكيميا + +151 +00:11:28,820 --> 00:11:31,800 +هذه الـ helibroma helicide يصير الـ helices أو + +152 +00:11:31,800 --> 00:11:35,480 +يصيرها destruction الخلايا هذه فيها حبيبات + +153 +00:11:35,480 --> 00:11:41,550 +الحبيبات هذه فيها مواد بتعمل coagulationand بتبعوا + +154 +00:11:41,550 --> 00:11:44,550 +fibrinolysis يعني بتشجع عملية الـ coagulation and + +155 +00:11:44,550 --> 00:11:48,030 +fibrinolysis وطبعا هذه تؤدي يعني بتنشط ال + +156 +00:11:48,030 --> 00:11:51,210 +coagulation و ال fibrinolysis هذا بيؤدي لإياش لـ + +157 +00:11:51,210 --> 00:11:54,810 +disseminated intravascular coagulation فعادة + +158 +00:11:54,810 --> 00:11:58,530 +بيتبعوا هذا bleeding و بتكون ال prognosis سيئة على + +159 +00:11:58,530 --> 00:12:06,410 +المريض عادة بتحصل في عمر متوسط 39 سنةبتتميز هذه بـ + +160 +00:12:06,410 --> 00:12:09,770 +Translocation 15 إلى 17 بـ chromosomal + +161 +00:12:09,770 --> 00:12:15,050 +translocation هذه الخلايا الـ Bromoylocyte فيها + +162 +00:12:15,050 --> 00:12:20,290 +أزوروفيليك جرانيول زي ما انتوا شايفين هيها والـ + +163 +00:12:20,290 --> 00:12:25,090 +granules فيها كتير واضحة طيب نيجي للنوع التاني + +164 +00:12:25,090 --> 00:12:28,170 +اللي هو الـ Hypogranular Bromoylocyte leukemia + +165 +00:12:28,170 --> 00:12:33,630 +بتتميز بوجود Bromoylocyte بس الـ Bromoylocyte هذه + +166 +00:12:34,110 --> 00:12:39,910 +hypogranular يعني الـ granules فيها قليلة و بتشكل + +167 +00:12:39,910 --> 00:12:42,950 +ال blast فيها تلقى اكتر من 30% في ال bone marrow + +168 +00:12:42,950 --> 00:12:47,670 +نفس الاشي ممكن العلاج يتسبب بال DIC و فيها + +169 +00:12:47,670 --> 00:12:54,370 +translocation 15-17 chromosomal translocation هاي + +170 +00:12:54,370 --> 00:13:01,070 +الخلايا bromielocyte بس الـ granules عيطها fine M4 + +171 +00:13:01,070 --> 00:13:07,710 +AML M4م4 زي ما حكينا هي acute myelomonoplastic + +172 +00:13:07,710 --> 00:13:12,990 +leukemia acute myelomonoplastic يعني فيها myeloid + +173 +00:13:12,990 --> 00:13:19,790 +precursors و monoplastic precursors طبعا هذه ال + +174 +00:13:19,790 --> 00:13:22,610 +precursors بشوفها سواء في الـ bone marrow أو في + +175 +00:13:22,610 --> 00:13:28,530 +البرفرال إبلط دايما لما يكون في الـ leukemia + +176 +00:13:28,530 --> 00:13:33,430 +monocytic precursorsهذه الـ Monocytic Precursors + +177 +00:13:33,430 --> 00:13:37,410 +لها القدرة على إنها تعمل Infiltration في الـ body + +178 +00:13:37,410 --> 00:13:41,470 +تشوف في أماكن خارج Extra Medullary Sites يعني ممكن + +179 +00:13:41,470 --> 00:13:45,890 +تعمل Infiltration في أماكن مختلفة من الجسم أكتر من + +180 +00:13:45,890 --> 00:13:48,950 +اللي هي الـ Granulocytic Types تشوفين الـ + +181 +00:13:48,950 --> 00:13:53,610 +Monocytic Precursors موجودة هنا بشكل واضح + +182 +00:13:53,610 --> 00:13:58,710 +Monoblast هدول Monoblast وهدول اللي فيهم Fisher + +183 +00:13:58,710 --> 00:14:03,820 +Bro Monocytesالـ M5 طبعاً بتتميز بإنها acute + +184 +00:14:03,820 --> 00:14:09,260 +monoplastic leukemia أكتر من 80% من الـ non + +185 +00:14:09,260 --> 00:14:12,800 +-erythroid cells عبارة عن monoplastic و monocytic + +186 +00:14:12,800 --> 00:14:13,640 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +187 +00:14:13,640 --> 00:14:13,980 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +188 +00:14:13,980 --> 00:14:14,540 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +189 +00:14:14,540 --> 00:14:14,620 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +190 +00:14:14,620 --> 00:14:14,760 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +191 +00:14:14,760 --> 00:14:23,340 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +192 +00:14:23,340 --> 00:14:26,980 +«مونوبلاستيك» «م + +193 +00:14:30,680 --> 00:14:34,500 +This form is further is divided into تنقسم إلى + +194 +00:14:34,500 --> 00:14:42,540 +نوعين M5A و M5B M5A عبارة عن purely differentiated + +195 +00:14:42,540 --> 00:14:47,760 +leukemia كيف يعني؟ هلاقي أكتر من 80% من الخلايا + +196 +00:14:47,760 --> 00:14:54,220 +monoblast M5B والـ differentiated الـ 80% هدول + +197 +00:14:54,220 --> 00:15:00,060 +هتلاقي منهم monoblast promonocyte و monocyte تمام؟ + +198 +00:15:04,410 --> 00:15:09,890 +هنا M5A أعتقد يعني هذي لأنه اللي موجودين بس Blast + +199 +00:15:09,890 --> 00:15:14,810 +اعتبرت M5A ليش عندي other stages من الـ Monocyte + +200 +00:15:14,810 --> 00:15:22,250 +التي رزقها هذي M5B لأنه موجود فيها Monoblast موجود + +201 +00:15:22,250 --> 00:15:28,830 +فيها Bromonocyte عشان أحط المؤشر بس موجود فيها + +202 +00:15:28,830 --> 00:15:33,970 +Monoblast موجود فيها Bromonocytehybromonocyte اللي + +203 +00:15:33,970 --> 00:15:37,230 +بتتميز بوجود single fissure في الخلية موجود فيها + +204 +00:15:37,230 --> 00:15:42,230 +mature monocyte علشان هيك بنعتبرها M5B الـ M6 + +205 +00:15:42,230 --> 00:15:47,370 +طبعاً بيسميها erythrochemia لأنه بتتميز بإن الـ + +206 +00:15:47,370 --> 00:15:49,890 +erythroblast بتلاقيها predominant في الـ bone + +207 +00:15:49,890 --> 00:15:53,770 +marrow وزي ما قلتلكم الخلايا بتلاقيها this plastic + +208 +00:15:53,770 --> 00:15:58,110 +يعني في abnormality في ال maturation الخلايا شوفوا + +209 +00:15:58,110 --> 00:16:01,630 +كيف ان هو يعني فيها segmentation طبعا هذا حاجة + +210 +00:16:01,630 --> 00:16:07,150 +abnormalطبعاً إلها تلت مراحل من ناحية الـ + +211 +00:16:07,150 --> 00:16:09,950 +Morphology المرحلة الأولى إني بلاقي Abnormal + +212 +00:16:09,950 --> 00:16:13,770 +Normoblast موجودة بكمية كبيرة هذه المرحلة الأولى + +213 +00:16:13,770 --> 00:16:18,750 +المرحلة التانية Erythroluchemia هيصير زيادة في الـ + +214 +00:16:18,750 --> 00:16:23,290 +Erythroblast و الـ Myeloblast ممكن تتطور للمرحلة + +215 +00:16:23,290 --> 00:16:26,390 +التالتة إنها تتحول لـ Myeloblastic Leukemia تتصير + +216 +00:16:26,390 --> 00:16:32,570 +M1 أو M2 أو M4 تمام هذه هي المراحل بتاعة الـ M6 + +217 +00:16:33,480 --> 00:16:37,420 +طبعاً شاقع فيها الأنيميا لأنه هي أساساً بتضرب الـ + +218 +00:16:37,420 --> 00:16:40,360 +Erythroid precursors شايفين كلها هذه Erythroid + +219 +00:16:40,360 --> 00:16:47,380 +precursors الـ + +220 +00:16:47,380 --> 00:16:53,300 +M7 طبعاً الـ M7 بتميز بإنها acute megakaryoblastic + +221 +00:16:53,300 --> 00:16:58,420 +leukemia عبارة عن rare disorder بتميز بـ extensive + +222 +00:16:58,420 --> 00:17:03,530 +proliferation of megakaryoblast اللي هيوجود برضه a + +223 +00:17:03,530 --> 00:17:09,030 +typical megakaryocyte and thrombocytopenia الخليط + +224 +00:17:09,030 --> 00:17:13,830 +الـ Megakaryoblast هذه هي بتتميز بأن الـ cytoplasm + +225 +00:17:13,830 --> 00:17:17,570 +بتاعها قليل وغامق كتير وفيه نتوقات أو بروزات على + +226 +00:17:17,570 --> 00:17:26,050 +شكل plebs موجودة حوالين الخلية يعني + +227 +00:17:26,050 --> 00:17:31,650 +جيلة جزئية الـ cytochemistry الأصبافالأساسية اللي + +228 +00:17:31,650 --> 00:17:34,390 +بنستخدمها الـ Special Stains اللي بنستخدمها عشان + +229 +00:17:34,390 --> 00:17:37,850 +نميز بين أنواع اللوكيميا زي ما قلنا إن اللوكيميا + +230 +00:17:37,850 --> 00:17:41,450 +لازم أستخدم إلها Special Stains عشان أتميز عند + +231 +00:17:41,450 --> 00:17:44,970 +الخلايا عن بعض لأن أحيانًا كتير الـ Blast بيكون + +232 +00:17:44,970 --> 00:17:48,690 +صعب جدًا أفصل يعني أفصلها، بيبقى تشابه كتير كتير + +233 +00:17:48,690 --> 00:17:51,950 +فيها خاصة في حالات اللوكيميا فبيكون من الصعوبة + +234 +00:17:51,950 --> 00:17:54,510 +بمكان أني أفصلها عن بعض عشان هيك أنا بستخدم + +235 +00:17:54,510 --> 00:17:57,430 +Special Stain أو اللي بسميه Cytochemistry + +236 +00:17:58,010 --> 00:18:01,410 +cytochemistry لأن التفاعل الكيميائي بيصير في داخل + +237 +00:18:01,410 --> 00:18:09,990 +الخلية طيب بداية بدي أفصل ال-AML عن ال-ALL أستخدم + +238 +00:18:09,990 --> 00:18:12,990 +الـmyelobroxidase أحنا عارفين أن الـmyeloid + +239 +00:18:12,990 --> 00:18:16,590 +والـmonocytic precursors هأخدوا بالكم الـmyeloid + +240 +00:18:16,590 --> 00:18:19,890 +والـmonocytic بتحتوي على الـmyelobroxidase + +241 +00:18:19,890 --> 00:18:23,390 +فبالتالي هتعطيني positive بينما الـlymphoid + +242 +00:18:23,390 --> 00:18:29,740 +هتعطيني negative تمام؟واللي بعمل يعني و اللي بيدعم + +243 +00:18:29,740 --> 00:18:32,420 +هذه الصبغة أو بيأكدها أو بيعمللها confirmation + +244 +00:18:32,420 --> 00:18:35,980 +برضه هي إن تطلع معايا نتائج مش كتير واضحة بالـ + +245 +00:18:35,980 --> 00:18:40,060 +Myelobroxidase أو يعني في شك فيها ممكن أؤكد نتيجتي + +246 +00:18:40,060 --> 00:18:43,080 +بالـ Sudan Blot Sudan Blot بيعطيني نفس نتائج + +247 +00:18:43,080 --> 00:18:47,800 +Myelobroxidase بيعطيني في الـ AML positive وفي ال + +248 +00:18:47,800 --> 00:18:52,160 +ALL بيعطيني negative تمام؟ إذا نرجع تاني + +249 +00:18:52,160 --> 00:18:57,070 +Myelobroxidase تعطيني positive في الـ acuteMyeloid + +250 +00:18:57,070 --> 00:19:00,350 +Leukemia يعني بالـ Myeloid Cell و بالـ Monocytic + +251 +00:19:00,350 --> 00:19:04,110 +Cell بينما في الانفايد بتعطيني Negative طيب في + +252 +00:19:04,110 --> 00:19:08,490 +خالة الـ Myeloperoxidase بتعطيني فيها Negative في + +253 +00:19:08,490 --> 00:19:13,490 +الـ AML إيش هي قلناها اللي هي الـ M0 لأن لسه + +254 +00:19:13,490 --> 00:19:17,010 +الإنزايم بيكونش متكون لدرجة إنه يقدر يعطيني + +255 +00:19:17,010 --> 00:19:20,270 +Positive Reaction Visible أقدر أشوفه فبالتالي الـ + +256 +00:19:20,270 --> 00:19:25,720 +M0 هتعطيني AML Negative و ALL Negativeهذه الملاحظة + +257 +00:19:25,720 --> 00:19:31,020 +مهمة الـ MZ روح تعطيني في التنتين negative طيب، + +258 +00:19:31,020 --> 00:19:35,960 +الآن احنا فصلنا إذا كانت مثلا acute myeloid والـ + +259 +00:19:35,960 --> 00:19:39,960 +acute lymphocytic leukemia طبعا، بس ما فصلنا الـ + +260 +00:19:39,960 --> 00:19:42,920 +myeloid عن الـ monocyte بنيجي بالـ non-specific + +261 +00:19:42,920 --> 00:19:47,380 +stress الـ non-specific stress بتفصل ليه؟الـ + +262 +00:19:47,380 --> 00:19:51,620 +Myelite بتعطيني Negative Non-specific stress بينما + +263 +00:19:51,620 --> 00:19:55,200 +الـ Monocytic اللي هي فيها M4 و M4 فيها Monocytic + +264 +00:19:55,200 --> 00:19:59,940 +cells هتعطيكي Non-specific stress Positive تمام؟ + +265 +00:19:59,940 --> 00:20:04,000 +إذن الـ Non-specific stress فصلي الـ Myelite عن + +266 +00:20:04,000 --> 00:20:06,280 +الـ Monocytic الـ Monocytic بتعطيني Positive + +267 +00:20:06,280 --> 00:20:09,200 +الميليت في الـ Non-specific stress بتعطيني Ash + +268 +00:20:09,200 --> 00:20:15,140 +بتعطيني Negative طيب بعد هيك بنيجي للـ BAS الـ BAS + +269 +00:20:16,990 --> 00:20:21,790 +الـ BAS عادة بتعطيني positive في الـ lymphoid الـ + +270 +00:20:21,790 --> 00:20:24,450 +common أن الـ BAS بتعطيني positive في الـ lymphoid + +271 +00:20:24,450 --> 00:20:30,510 +بالإضافة للـ M6 من الـ myeloid تعطيني يعني للـ + +272 +00:20:30,510 --> 00:20:32,970 +lymphoid precursor و للـ erythroid precursor + +273 +00:20:32,970 --> 00:20:39,270 +بتعطيني positive لـ M6 و لـ ALL طيب نيجي للـ acid + +274 +00:20:39,270 --> 00:20:44,410 +phosphatase الـ acid phosphatase عادة بيعطيني في + +275 +00:20:44,410 --> 00:20:49,370 +الـ AML negativeوفي الـ ALL في الـ T cell acute + +276 +00:20:49,370 --> 00:20:53,730 +lymphocytic leukemia هيعطيكي positive اللي هو مين؟ + +277 +00:20:53,730 --> 00:20:56,450 +الـ acid phosphatase إذا كنتوا فاكرين أكتر حاجة + +278 +00:20:56,450 --> 00:21:00,450 +استخدمناها للفصل أو تمييز الهيريس اللوكيميا + +279 +00:21:00,450 --> 00:21:05,550 +الهيريس اللوكيميا طيب acute lymphoblastic leukemia + +280 +00:21:05,550 --> 00:21:10,550 +reactivity with specialists تمام؟ هلاقيت الـ L1 + +281 +00:21:10,550 --> 00:21:14,940 +تعطيني بالبيروكسيداز أو Sudan black negativeالـ + +282 +00:21:14,940 --> 00:21:18,920 +Non-specific stress نيجاتيف الـ BAS positive زي ما + +283 +00:21:18,920 --> 00:21:23,400 +قولنا الـ BAS بالقلب بالمفايد بتعطيني positive الـ + +284 +00:21:23,400 --> 00:21:27,780 +2 نفس الأشياء والقلب الـ 3 نفس الأشياء لكن هنا في + +285 +00:21:27,780 --> 00:21:32,040 +عندي exception بدنا ناخد بالنا منه يعني هو هنا الـ + +286 +00:21:32,040 --> 00:21:36,560 +peroxidase are sudan black ماشي طبقنا عليهم هم بس + +287 +00:21:36,560 --> 00:21:41,260 +هنا في exception للـ sudan black الـ L3 بتتميز + +288 +00:21:41,260 --> 00:21:43,920 +الخلايا بتاعتها إنها vaculated إذا كنتوا فاكدينا + +289 +00:21:44,200 --> 00:21:46,940 +وقلنا إيش سبب الـ vacuoles سبب الـ vacuoles يعني + +290 +00:21:46,940 --> 00:21:51,280 +إنه فيه fat في قلب الخلية ولمّا أنا بحط الكحول للـ + +291 +00:21:51,280 --> 00:21:55,080 +fixation بتدوب الـ fat هذه وبتترك مكانها فجوات الـ + +292 +00:21:55,080 --> 00:21:59,900 +sudan black صبغة مخصصة لصبارة الـ fat فبالتالي + +293 +00:21:59,900 --> 00:22:03,800 +أكيد هتعطيني positive مع الـ L3 ليش؟ لأن الخلية + +294 +00:22:03,800 --> 00:22:06,700 +فيها fat فبالتالي يعتبر الـ sudan black هنا + +295 +00:22:06,700 --> 00:22:10,420 +exception لـ L البركتينفعمة أو L3 لأنه يعطي معاها + +296 +00:22:10,420 --> 00:22:13,810 +positiveتمام؟ exception الوحيد اللي هو السودان + +297 +00:22:13,810 --> 00:22:23,690 +black positive في الـ L3 بأكتب عن نقطة هذه نيجي + +298 +00:22:23,690 --> 00:22:27,770 +للـ Immunophenotyping الـ Immunophenotyping + +299 +00:22:27,770 --> 00:22:32,030 +بيستخدم بشكل يعني أكتر وبشكل أساسي للتمييز بين + +300 +00:22:32,030 --> 00:22:37,390 +أنواع الـ B والـT لمفوسايت والدرجة ال maturation + +301 +00:22:37,390 --> 00:22:42,070 +لإلها الـ A بالنسبة للخلايا أووالتباعت بتعتمد على + +302 +00:22:42,070 --> 00:22:46,770 +إيش؟ إن الخلايا خلال الـ maturation لإلها بتتميز + +303 +00:22:46,770 --> 00:22:49,270 +عليها الـ CDs اللي هي الـ clusters of + +304 +00:22:49,270 --> 00:22:53,530 +differentiation طبعا هذه كل مرحلة من مراحل الـ + +305 +00:22:53,530 --> 00:22:58,010 +maturation بتاع الخلية بتميز وجود CDs مختلفة عن + +306 +00:22:58,010 --> 00:23:01,710 +المرحل اللي قبلها فمن خلال معرفتنا لنوع الـ CD + +307 +00:23:01,710 --> 00:23:05,290 +الموجود على سطح الخلية نقدر نعرف أي stage من + +308 +00:23:05,290 --> 00:23:10,850 +الخلية وصلالهاليش؟ لأنه الـ … يعني ممكن بتلاحظوا + +309 +00:23:10,850 --> 00:23:14,770 +في الـ … في الـ lymphocytic maturation مافيش عندي + +310 +00:23:14,770 --> 00:23:18,670 +هالـ morphological changes اللي ممكن ألاحظها زي + +311 +00:23:18,670 --> 00:23:21,670 +الـ Myeloid الـ Myeloid كنا نقدر نميز كتير الـ + +312 +00:23:21,670 --> 00:23:24,730 +Myeloblast عن الـ Bromielocyte عن الـ لكن الـ + +313 +00:23:24,730 --> 00:23:28,250 +lymphocyte من lymphoblast و Bromielocyte الـ + +314 +00:23:28,250 --> 00:23:31,850 +mature lymphocyte كتير في تقارب بالـ بالـ + +315 +00:23:31,850 --> 00:23:34,950 +morphology لإلهم فاحنا بدنا نلجأ لطريقة أخرى + +316 +00:23:34,950 --> 00:23:39,740 +للتمييزوطبعاً طريقة دقيقة وبتميز عندى في أي مرحلة + +317 +00:23:39,740 --> 00:23:43,160 +أو بتحدد عندى في أي مرحلة الخلية من الـ Maturation + +318 +00:23:43,160 --> 00:23:48,480 +الهدد تعتمد على أنه أنا بدور على CD معين مثلا Body + +319 +00:23:48,480 --> 00:23:52,800 +Flow Labeled Antibody بـ Fluorescence إذا كان رطبط + +320 +00:23:52,800 --> 00:23:55,840 +الخلية بهذا Labeled Antibody طبعاً فيه direct و + +321 +00:23:55,840 --> 00:23:58,600 +indirect هحكيهم بالـ Slider اللي بعدها عشان في + +322 +00:23:58,600 --> 00:24:02,700 +رسمة بالتوضيح هحكيهم بالتفصيللكن أنا بشكل أساسي + +323 +00:24:02,700 --> 00:24:05,820 +بدور على ماركر معين بضيفله antibody labelled ب + +324 +00:24:05,820 --> 00:24:10,240 +fluorescence إذا ارتبط فيه، هيعطيني واميد الآن + +325 +00:24:10,240 --> 00:24:15,620 +بمرر الخلايا هذه على ال flow cytometer فهيعد + +326 +00:24:15,620 --> 00:24:19,280 +الخلايا اللي هي labelled بال fluorescence ويحدد + +327 +00:24:19,280 --> 00:24:22,400 +مين الخلايا ال positive لهذا ال marker ومين + +328 +00:24:22,400 --> 00:24:26,040 +الخلايا ال negative بالنسبة لل principle، هشرحها + +329 +00:24:26,040 --> 00:24:31,220 +في ال slide ده في عندي directأو Indirect Labeling + +330 +00:24:31,220 --> 00:24:35,500 +للـ Antigen يعني أنا بدي أتخيل عندي هذه الخلية + +331 +00:24:35,500 --> 00:24:41,800 +عليها يعني Marker معين أنا بدور عليها بشوف هل الـ + +332 +00:24:41,800 --> 00:24:45,580 +Marker هذا موجود ولا لأ بجيبله Antibody و بربطه + +333 +00:24:45,580 --> 00:24:50,260 +فيه في عندي طريقتين للشغل في طريقة Indirect اني + +334 +00:24:50,260 --> 00:24:56,100 +أنا مباشرة بجيب Antibody label ب fluorescence خاص + +335 +00:24:56,100 --> 00:25:01,840 +بهذا الـ Antigen و بربطه فيهطبعًا إذا كان ارتبط + +336 +00:25:01,840 --> 00:25:06,320 +خلاص بعد هيك بعمل Washing عشان أغزل الـ Excess من + +337 +00:25:06,320 --> 00:25:09,500 +هذا الـ Antibody الزيادة من هذا الـ Antibody بدي + +338 +00:25:09,500 --> 00:25:13,700 +أغسلها عشان ما تعملش عندي خلال في القراءة فإيش + +339 +00:25:13,700 --> 00:25:17,380 +اللي بيضل عندي؟ هيضل عندي كل الخلايا المرتبطة بالـ + +340 +00:25:17,380 --> 00:25:20,400 +Antibody label وبتم عدها من خلال جهاز + +341 +00:25:20,400 --> 00:25:25,100 +Fluocytometer هذه الطريقة إيش؟ Direct سمناها + +342 +00:25:25,100 --> 00:25:28,050 +Directلأن الـ Antibody اللي أنا استه Directly + +343 +00:25:28,050 --> 00:25:31,390 +ارتبط بالـ Antigen الطريقة التانية اللي هي + +344 +00:25:31,390 --> 00:25:35,870 +Indirect بيكون في عندي Two Antibodies واحد فيهم + +345 +00:25:35,870 --> 00:25:41,150 +بيرتبط مباشرة بالـ Antigen اللي أنا بدور عليه أو + +346 +00:25:41,150 --> 00:25:46,510 +الـ Marker اللي أنا بدور عليه الآن بيكون في عندي + +347 +00:25:46,510 --> 00:25:53,830 +Antibody للـ FC portion للـ Antibody الأولاني يعني + +348 +00:25:53,830 --> 00:25:56,650 +في عندي Primary Antibody ارتبطوالـ Secondary + +349 +00:25:56,650 --> 00:25:59,690 +Antibody راح يرتبط بالـ Primary طب فإيش هيرتبط؟ + +350 +00:25:59,690 --> 00:26:05,770 +هيرتبط بالـ FC-LALO الآن الـ Second Antibody هو + +351 +00:26:05,770 --> 00:26:11,070 +اللي label الـ Second Antibody هو اللي label فالآن + +352 +00:26:11,070 --> 00:26:16,670 +بعمل Washing بعمل بعد ال Washing يعني طبعا بشيل أي + +353 +00:26:16,670 --> 00:26:20,570 +Antibody مرتبطش يعني عندي Washing أولاني بعمله في + +354 +00:26:20,570 --> 00:26:26,160 +المرحلة هذهبشيل عندي أي Primary Antibody مرتبطش + +355 +00:26:26,160 --> 00:26:29,840 +بيبقى عندي مين اللي مرتبط الـ Primary Antibody مع + +356 +00:26:29,840 --> 00:26:31,560 +الـ Antigen هو اللي بيبقى عندي في الـ Reaction + +357 +00:26:31,560 --> 00:26:36,760 +Mixture الآن باضيف الـ Labeled Antibody Labeled + +358 +00:26:36,760 --> 00:26:40,560 +Antibody هيرتبط مع الـ Antibody اللي كان مرتبط على + +359 +00:26:40,560 --> 00:26:44,560 +سطح الخلية ويتكون عندي هذا الـ Complex الـ Complex + +360 +00:26:44,560 --> 00:26:48,640 +هذا هيمر على جهاز الـ Fluocytometer ويقرأ الـ + +361 +00:26:48,640 --> 00:26:53,310 +Fluorescence لإلهالآن برضه قبل ما أمرره الخطوة + +362 +00:26:53,310 --> 00:26:56,570 +الأخيرة لازم أعمل Washing عشان أتخلص من أي + +363 +00:26:56,570 --> 00:26:59,830 +Labelled Unbound Antibody يعني هنا في عملية + +364 +00:26:59,830 --> 00:27:03,170 +Washing مرتين أتخلص من الـ Antibody الـ Unbound في + +365 +00:27:03,170 --> 00:27:06,370 +المرحلة الأولى و أتخلص من الـ Antibody الـ Unbound + +366 +00:27:06,370 --> 00:27:10,330 +في المرحلة التانية طبعا هنا سميناها Indirect لأن + +367 +00:27:10,330 --> 00:27:14,200 +كان مائس Antibody المرتبط مباشرة بالـ Antigenأنا + +368 +00:27:14,200 --> 00:27:17,400 +قصدت الـAntibody المرتبط بالـAntibody الـPrimary + +369 +00:27:17,400 --> 00:27:20,560 +الـSecondary Antibody اللي تم قياسه مش الـPrimary + +370 +00:27:20,560 --> 00:27:25,200 +Antibody هيك بنكون أعرفنا كيف الإرتباط بيكون + +371 +00:27:25,200 --> 00:27:30,460 +Direct أو Indirect نيجي + +372 +00:27:30,460 --> 00:27:37,220 +للـTDT اللي هو Terminal Deoxydidyltransferase هذا + +373 +00:27:37,220 --> 00:27:43,410 +عبارة عن DNA بولميرازيكون موجود في الـ B و الـ T + +374 +00:27:43,410 --> 00:27:46,590 +precursors في الـ lymphoid precursors يعني في الـ + +375 +00:27:46,590 --> 00:27:52,610 +stem cells عادة بلاقيه بـ high levels في تقريبا 90 + +376 +00:27:52,610 --> 00:27:57,370 +% من حالات الـ lymphoblastic leukemia ممكن أحدده + +377 +00:27:57,370 --> 00:28:00,930 +باستخدام برضه labelled antibody وباستخدام ال flow + +378 +00:28:00,930 --> 00:28:03,610 +cytometry زي ما حكينا طوي عن ال cluster of + +379 +00:28:03,610 --> 00:28:08,510 +differentiationعدّي هفرزلكم جداول وانميز الخلايا + +380 +00:28:08,510 --> 00:28:11,990 +من خلال أشياء معينة في الشرائح القادمة هيكون + +381 +00:28:11,990 --> 00:28:14,570 +الموضوع أوضح بشكل واحد طيب، نيجي إلى + +382 +00:28:14,570 --> 00:28:18,510 +الـClassification بناء على الـ Cell Markers الـAML + +383 +00:28:18,510 --> 00:28:23,250 +والـALL حناخد أول إشي الـAML الـAML بتتميز غالبا + +384 +00:28:23,250 --> 00:28:27,850 +بوجود الـCD13 و33 هدول الاتنين بيكونوا positive + +385 +00:28:27,850 --> 00:28:33,350 +فيها بينما الـTDTnegative ليش؟ لأنها لأنه بيكون + +386 +00:28:33,350 --> 00:28:35,850 +positive في الـ lymphoid precursors ما بيكون في + +387 +00:28:35,850 --> 00:28:40,090 +الـ myeloid precursors الآن نيجي لحاجات خاصة يعني + +388 +00:28:40,090 --> 00:28:43,570 +مثلا الـ M6 بلاقي فيها الـ glycophorin A positive + +389 +00:28:43,570 --> 00:28:51,510 +تمام الـ M7 بلاقي فيها الـ CD41 و 42 و 61 positive + +390 +00:28:51,510 --> 00:28:58,090 +اللي هي الـ acute megakaryoplastic leukemia هنا + +391 +00:28:58,780 --> 00:29:05,700 +بتم يعني الـ ALL في منها Precursor B ALL في عندي B + +392 +00:29:05,700 --> 00:29:11,720 +ALL وفي عندي T Acute Lymphoblastic Leukemia طبعا + +393 +00:29:11,720 --> 00:29:15,040 +الـ Markers اللي بدنا نصنف بناء عليها اللي هي CD + +394 +00:29:15,040 --> 00:29:22,200 +CD19, 22, TDT, 10 Intracytoplasmic chains Surface + +395 +00:29:22,200 --> 00:29:29,210 +Immunoglobulin CD7, CD3والـ Morphology related to + +396 +00:29:29,210 --> 00:29:35,150 +which type الـ 1 أو الـ 2 أو الـ 3 أول حاجة لـ + +397 +00:29:35,150 --> 00:29:40,010 +Precursor B ALL في منها تلت أنواع نوع بيسموه + +398 +00:29:40,010 --> 00:29:46,650 +Common ALL Common ALL بتلاقي الـ 19 و 22 و الـ TDT + +399 +00:29:46,650 --> 00:29:51,490 +و العشرة positive تمام؟ الـ Null type بتفرق عنها + +400 +00:29:51,490 --> 00:29:55,820 +إن العشرة فيها negative CD10 فيها negativeلمّا + +401 +00:29:55,820 --> 00:29:59,600 +بيكون مش مكتوب حاجة يعني حاجة مش مميزة يعني لا + +402 +00:29:59,600 --> 00:30:02,780 +بقدر أقول ممكن تكون positive أو negative مش بشكل + +403 +00:30:02,780 --> 00:30:05,360 +منتظم يعني مش دايما positive ومش دايما negative + +404 +00:30:05,360 --> 00:30:07,860 +فبالتالي لمّا المنطقة الضباطية هذه اللي ماعليهاش + +405 +00:30:07,860 --> 00:30:11,580 +positive أو negative يعني لا تستخدم في التمييز أو + +406 +00:30:11,580 --> 00:30:16,550 +في تحديد هذه الأنواع من الـ Locateالـ Pre-B cell + +407 +00:30:16,550 --> 00:30:22,430 +الـ Pre-B cell هلاقيهم تقريبا متشابهة الـ CD10 + +408 +00:30:22,430 --> 00:30:25,170 +variable ممكن يبقى positive أو negative إيش بزيد + +409 +00:30:25,170 --> 00:30:28,950 +عليها؟ الـ Intra-cytoplasmic chain إيش هي الـ + +410 +00:30:28,950 --> 00:30:31,490 +Intra-cytoplasmic chain؟ الـ Intra-cytoplasmic + +411 +00:30:31,490 --> 00:30:36,290 +chain هو عبارة عن الـ surface immunoglobulin وهو + +412 +00:30:36,290 --> 00:30:39,370 +عمال بتصنع في داخل الـ cytoplasm يعني هو لسه ما + +413 +00:30:39,370 --> 00:30:42,990 +طلعت على فتح الخلية هنا بلاقي في الـ Pre-B cell + +414 +00:30:42,990 --> 00:30:48,440 +positiveبعدين بيجي عند الـ قولنا الـ precursor + +415 +00:30:48,440 --> 00:30:52,540 +قسمناها لتلاتة بتيجي عند الـ BALL وبتيجي عند الـ + +416 +00:30:52,540 --> 00:30:59,000 +TALL الـ BALL طبعا الـ CD10 فيها negative والـ + +417 +00:30:59,000 --> 00:31:03,380 +surface immunoglobulin negative الـ TALL فيها الـ + +418 +00:31:03,380 --> 00:31:11,400 +CD10 positive هلقيت الـ null type ممكن تكون L1 أو + +419 +00:31:11,400 --> 00:31:17,600 +L2 طبعا common ممكن تكون أي نوعالـ Null Type قلنا + +420 +00:31:17,600 --> 00:31:23,900 +L1 أو L2 الـ Pre-B برضه قد تكون L1 أو L2 الـ BALL + +421 +00:31:23,900 --> 00:31:32,220 +غالباً L3 الـ TALL TALL قلتلكم الـ CD10 فيها بتكون + +422 +00:31:32,220 --> 00:31:38,560 +Positive تتميز الـ T بالـ CD7 والـ CD3 فدول اتنين + +423 +00:31:38,560 --> 00:31:43,240 +بيكونوا Positive وممكن تكون على شكل L1 أو L2ماشي + +424 +00:31:43,240 --> 00:31:45,820 +يعني على شكل الخلايا ماخدة الـ Criteria + +425 +00:31:45,820 --> 00:31:55,700 +المورفولوجي تاعة الـ L1 أو الـ L2 طيب + +426 +00:31:55,700 --> 00:31:58,580 +نيجي إلى الـ Classification هل هي B أو T + +427 +00:31:58,580 --> 00:32:03,240 +-Lymphocyte؟ يعني بناء على الـ Markers معينة هنشوف + +428 +00:32:03,240 --> 00:32:07,880 +إذا كانت B Lineage أو T الـ B بتشكل 80% والـ T + +429 +00:32:07,880 --> 00:32:13,130 +بتشكل 20% الـ Markers اللي هنفصل من خلالهاالـ B + +430 +00:32:13,130 --> 00:32:18,310 +عادة الـ TdT بتكون فيها positive فكل ما تخلية M + +431 +00:32:18,310 --> 00:32:21,670 +mature بتكون فيها الـ TdT positive يعني في عندي في + +432 +00:32:21,670 --> 00:32:27,410 +الـ Bra B وفي عندي Common وفي عندي Pre-B يعني الـ + +433 +00:32:27,410 --> 00:32:31,530 +Bra B مرحل السابق للـ Pre-B بعدين ال mature B + +434 +00:32:31,530 --> 00:32:35,750 +هتلاقي فيهم الـ TdT positive بس في ال mature هتصير + +435 +00:32:35,750 --> 00:32:39,310 +negative لأن مع ال matureation هتلاقيها بلشات + +436 +00:32:39,310 --> 00:32:44,500 +تختفي الـ Cd19 هتلاقيها positive في كل الـB + +437 +00:32:44,500 --> 00:32:50,280 +الـCD10 positive ما عدا في الـBra B الـSurface + +438 +00:32:50,280 --> 00:32:56,040 +immunoglobulin هو احنا المفروض نقول الـCytoplasmic + +439 +00:32:56,040 --> 00:33:00,360 +immunoglobulin لأنه بظهر في مراحل الـSurface يعني + +440 +00:33:00,360 --> 00:33:04,360 +هو أول شي بظهر في الـCytoplasmic على سطح الخلية + +441 +00:33:04,360 --> 00:33:07,920 +فبالتالي الـCytoplasmic ممكن نلاقيه في الـPre-B + +442 +00:33:07,920 --> 00:33:12,850 +وفي الـMature B تمام؟بعد هيك في الـ Surface + +443 +00:33:12,850 --> 00:33:16,350 +Immunoglobulin هتلاقيه بس في الـ Mature B لأن كل + +444 +00:33:16,350 --> 00:33:19,770 +الـ Cytoplasmic طلع على سطح الخلية وصار على شكل + +445 +00:33:19,770 --> 00:33:25,010 +Surface Immunoglobulin طيب نيجي للـ T الـ T عادة + +446 +00:33:25,010 --> 00:33:28,590 +بتتميز بالـ CD7 إنها positive والـ TDT برضه + +447 +00:33:28,590 --> 00:33:35,870 +positive طبعاً في عند الـ Pre-T و Mature-Tالـ CD2 + +448 +00:33:35,870 --> 00:33:39,270 +بيفرق أن الـ Pre-T بيبقى فيها Negative والـ Mature + +449 +00:33:39,270 --> 00:33:43,350 +-T بيكون فيها Positive طبعاً هذا بالزمن في ال + +450 +00:33:43,350 --> 00:33:45,870 +classification لنوع الـ acute lymphoblastic + +451 +00:33:45,870 --> 00:33:52,870 +leukemia اللي هي B أو T lymphoblast حطيت هذه + +452 +00:33:52,870 --> 00:33:56,210 +الصورة بس عشان يعني تاخدوا فكرة إيش اللي بيصير + +453 +00:33:56,210 --> 00:33:59,970 +فعلياًهي الـ Maturation بتاع الـ B-cell قلتلكم الـ + +454 +00:33:59,970 --> 00:34:02,510 +Maturation الشكل تقريبا متشابه جدا في الـ + +455 +00:34:02,510 --> 00:34:05,490 +lymphocyte maturation فبنميز من خلال الـ markers + +456 +00:34:05,490 --> 00:34:09,350 +كل مرحلة معينة من مراحل الـ maturation تتميز ب + +457 +00:34:09,350 --> 00:34:11,790 +markers معينة يعني في ال early stages بتلاقي + +458 +00:34:11,790 --> 00:34:15,830 +الـTDT positive لكن بعد هيك بتبدأ الـTDT بتختفي في + +459 +00:34:15,830 --> 00:34:21,750 +ال mature الـHLA-DR والـCD19 بتكون positive على + +460 +00:34:21,750 --> 00:34:25,830 +طول للآخر الـCD20 في مرحلة معينة بتظهر وبعدين + +461 +00:34:25,830 --> 00:34:29,950 +بتختفيالـ CD10 برضه نفس الأشي في مراحل بتكون + +462 +00:34:29,950 --> 00:34:33,910 +موجودة فيها المراحل بتكونش الـ immunoglobulin برضه + +463 +00:34:33,910 --> 00:34:38,210 +ممكن تكون موجودة مع الـ maturation بتبدأ تظهر على + +464 +00:34:38,210 --> 00:34:41,730 +سطح الخلية، تمام؟ هي صورة تانية للـ B cell + +465 +00:34:41,730 --> 00:34:45,530 +maturation هذه بس صور توضحية يعني هي الـ + +466 +00:34:45,530 --> 00:34:49,090 +progenerator cell الخلية الأولى هتلاقي فيها الـ + +467 +00:34:49,090 --> 00:34:52,610 +TdT positive اللي بعدها اللي بعدها بعد هيك الـ TdT + +468 +00:34:52,610 --> 00:34:57,010 +بطل positiveطيب، نيجي للـ Markers مثلا هذه بتتميز + +469 +00:34:57,010 --> 00:35:04,030 +بالـ CD 3419 هذه 3419 و 10 TDT هذه هتلاقي في عندك + +470 +00:35:04,030 --> 00:35:07,630 +TDT positive زي ما قلنا اللي هي الـ Pre-B cell + +471 +00:35:07,630 --> 00:35:13,670 +فيها 19 و 10 و 20 و 22 يعني الشاهد في الموضوع أن + +472 +00:35:13,670 --> 00:35:17,630 +كل مرحلة من المراحل هذه بتتميز بـ Markers خاصة + +473 +00:35:17,630 --> 00:35:20,510 +فيها الـ Chronic Lymphocytic Leukemia و الـ Pro + +474 +00:35:20,510 --> 00:35:23,440 +-Lymphocytic Leukemia برضه إلها Markersالـ Hair + +475 +00:35:23,440 --> 00:35:26,700 +Cell Leukemia برضه إلها Markers الـ Wild Storm + +476 +00:35:26,700 --> 00:35:32,140 +Heavy Chain Disease برضه إله Markers معينة الملطب + +477 +00:35:32,140 --> 00:35:36,800 +الميلومة إلها Markers معينة هيك بتتمييز الـ B Cell + +478 +00:35:36,800 --> 00:35:41,440 +Leukemia من خلال الـ Immunophenotyping عشان نعرف + +479 +00:35:41,440 --> 00:35:45,220 +أي Stage اللي هي عاملة الخلية فيها Proliferation + +480 +00:35:45,220 --> 00:35:52,670 +الـ T Cell نفس الإشي برضه كل مرحلةمن المراحل بتاعة + +481 +00:35:52,670 --> 00:35:56,590 +الـ Maturation للـ T cell هتلاقي إلها Markers خاصة + +482 +00:35:56,590 --> 00:35:57,030 +فيها + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY_raw.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..ec7f45ffa4541bb26b41fe8c2f9122db83d2520f --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/dmHwkmDynJY_raw.srt @@ -0,0 +1,1932 @@ +1 +00:00:01,690 --> 00:00:06,590 +بسم الله الرحمن الرحيم راح نبدأ مع بعض بإذن الله + +2 +00:00:06,590 --> 00:00:10,850 +في الجزئية التانية من المادة اللي هي تتعلق بالـ + +3 +00:00:10,850 --> 00:00:18,130 +Leukemia بأنواعها وتصنيفها نواصل مع بعض في أنواع + +4 +00:00:18,130 --> 00:00:21,850 +الـ Acute Leukemia طبعا حكينا قبل هيك عن الـ Acute + +5 +00:00:21,850 --> 00:00:26,250 +Lymphoid Leukemia حكينا عن ال classification لإلها + +6 +00:00:26,250 --> 00:00:30,410 +كاف الـ 1 و الـ 2 و الـ 3 الـ Acute Myeloid + +7 +00:00:30,410 --> 00:00:36,440 +Leukemiaبتقسم على حسب الـ bone marrow blast + +8 +00:00:36,440 --> 00:00:40,000 +morphology حسب الـ predominant cell الموجودة في + +9 +00:00:40,000 --> 00:00:42,840 +الـ bone marrow الـ morphology اللي قيلها ال + +10 +00:00:42,840 --> 00:00:47,160 +degree of cell maturation حسب عند أي stage وقفة + +11 +00:00:47,160 --> 00:00:51,720 +الخلية cytochemical stains الـ immunophenotyping + +12 +00:00:52,280 --> 00:00:57,480 +ممكن أسميها Acute Granulocytic Leukemia بس المشهور + +13 +00:00:57,480 --> 00:01:01,140 +أكتر Acute Myeloid Leukemia طبعاً هي بتاخد تقسيمات + +14 +00:01:01,140 --> 00:01:05,240 +زي ما حكينا من M0 إلى M7 نيجي لتفاصيل الـ Acute + +15 +00:01:05,240 --> 00:01:09,700 +Myeloid Leukemia اللي هي Acute Non-Lymphoblastic + +16 +00:01:09,700 --> 00:01:15,000 +Leukemia أول حاجة هي زي ما قلنا من M0 إلى M7 هناخد + +17 +00:01:15,000 --> 00:01:19,950 +كل واحدة إيش خصائص الخلايا الموجودة فيها بدايةنيجي + +18 +00:01:19,950 --> 00:01:25,530 +للـ M0 و M1 هدول التنتين يعني في تشابه بينهم عشان + +19 +00:01:25,530 --> 00:01:30,290 +هيك احنا بناخدهم من باب انه كيف نفرق بينهم أول شئ + +20 +00:01:30,290 --> 00:01:35,470 +التنتين هدول بلاقي فيهم Myeloblast لكن الـ M0 + +21 +00:01:35,470 --> 00:01:41,450 +بتكون الـ Myeloblast Early Myeloblast الـ M1 Late + +22 +00:01:41,450 --> 00:01:45,550 +Myeloblast طب إيش بتفرق الـ Early Myeloblast عن + +23 +00:01:45,550 --> 00:01:49,970 +الـ Late Myeloblast الـ Early Myeloblastبلاقي الـ + +24 +00:01:49,970 --> 00:01:54,010 +Myelobroxidase إنزايم فيها موجود بكمية ضئيلة جدًا + +25 +00:01:54,010 --> 00:01:58,110 +Ultra Structural لدرجة إنه بالـ Myelobroxidase + +26 +00:01:58,110 --> 00:02:01,510 +Stain العادية الـ Cytochemical Stain بعتنيش + +27 +00:02:01,510 --> 00:02:07,210 +Positive إذا الـ M0 MbO Negative Myelobroxidase + +28 +00:02:07,210 --> 00:02:12,150 +Stain Negative الـ M1 هي برضه Myeloblast لكن في + +29 +00:02:12,150 --> 00:02:17,010 +مرحلة متقدمة متطورة أكتر من اللي موجودة في الـ M0 + +30 +00:02:17,560 --> 00:02:22,400 +هذه ممكن أشوف فيها بداية الـ Azorophilic granules + +31 +00:02:22,400 --> 00:02:26,820 +بشكل خفيف ممكن أشوف فيها الـ Myelobroxidase لو + +32 +00:02:26,820 --> 00:02:30,440 +عملته هذا هيعطيني positive ممكن أشوف فيها الأول رد + +33 +00:02:30,440 --> 00:02:34,600 +الأول رد ما هي عبارة عن Azorophilic granules، صح؟ + +34 +00:02:34,600 --> 00:02:39,880 +فبالتالي الفرق بينهم في Myelobroxidase هنا هتلاقي + +35 +00:02:39,880 --> 00:02:43,680 +أن Myelobroxidase مع الـ maturation هتزيد ال + +36 +00:02:43,680 --> 00:02:47,180 +activity بتاعتهفدايةً هذا هتكون كميته قليلة جداً + +37 +00:02:47,180 --> 00:02:51,000 +ويعطيني بالـ cytokinical stain العادية negative + +38 +00:02:51,000 --> 00:02:56,120 +بأكدها بالـ immunophenotype الـ M1 AML without + +39 +00:02:56,120 --> 00:02:59,200 +maturation إيش أصدوا without maturation يعني بس + +40 +00:02:59,200 --> 00:03:02,200 +بشوف فيها blast هدول الفنتان بشوف فيهم بس blast + +41 +00:03:02,200 --> 00:03:07,700 +AML without maturation يعني ما بشوف في المراحل + +42 +00:03:07,700 --> 00:03:11,240 +التالية زي الـ Bromelocyte و الـ Myelocyte and so + +43 +00:03:11,240 --> 00:03:17,380 +onإيش مميزات الخلية؟ Monomorphic with one or more + +44 +00:03:17,380 --> 00:03:21,100 +distinct nuclei بشوف فيها نيوكليولاي Blast cell + +45 +00:03:21,100 --> 00:03:27,580 +occasional أورود and at least a 3% ميولوبروكسداز + +46 +00:03:27,580 --> 00:03:34,620 +positive يعني هذه ممكن أميزها أن هذه بأورود + +47 +00:03:34,620 --> 00:03:37,620 +والميولوبروكسداز يعني إذا نجد الأورود معنى الكلام + +48 +00:03:37,620 --> 00:03:41,080 +هي M1 إذا أعطتني الميولوبروكسداز positive غالبا هي + +49 +00:03:41,080 --> 00:03:41,840 +M + +50 +00:03:44,140 --> 00:03:51,160 +طيب نجي لـ M2 M2 AML with maturation بشوف فيها + +51 +00:03:51,160 --> 00:03:54,200 +Blast خدوا بقى لكوا يا بناة بأكد هنا أنه احنا + +52 +00:03:54,200 --> 00:03:57,020 +بنحكي عن acute يعني في الـ bone marrow لازم الـ + +53 +00:03:57,020 --> 00:04:00,780 +blast يكون على الأقل 20% عشان أعتبرها blast عشان + +54 +00:04:00,780 --> 00:04:08,110 +أعتبرها acute طبعاً M2 AML with maturation يعنيهنا + +55 +00:04:08,110 --> 00:04:12,410 +بلاقي Blast Cell بلاقي Myeloblast 50% أو أكتر + +56 +00:04:12,410 --> 00:04:16,850 +Myeloblast بلاقي Other Stages يعني هدول التنتين بس + +57 +00:04:16,850 --> 00:04:22,490 +Myeloblast لكن في هذه ممكن أشوف Raw Myelocyte ممكن + +58 +00:04:22,490 --> 00:04:26,810 +أشوف فيها أو الرد ممكن أشوف فيها برضه يعني Other + +59 +00:04:26,810 --> 00:04:29,850 +Stages ممكن في بعض الحين أشوف Myeloblast وممكن + +60 +00:04:29,850 --> 00:04:34,350 +أشوف Myelocyte وممكن أشوف Metamyelocyte والمراحل + +61 +00:04:34,350 --> 00:04:38,300 +ال mature أكتر يعني إذا شفتفيه maturation يعني + +62 +00:04:38,300 --> 00:04:43,340 +علامات الـ maturation موجودة غالبا بتكون AML M2 + +63 +00:04:43,340 --> 00:04:48,740 +this plastic myeloid differentiation may be + +64 +00:04:48,740 --> 00:04:52,100 +present يعني أحيانا بتبقى لاقي فيه dysplasia يعني + +65 +00:04:52,100 --> 00:04:55,440 +الخلايا ال maturation بتاعها مش طبيعي صح فيه + +66 +00:04:55,440 --> 00:04:58,420 +maturation لكن فيه abnormality في ال maturation في + +67 +00:04:58,420 --> 00:05:03,280 +أشكال الخلايا طيب نجي للـ M3 هذه مشهورة من إنها + +68 +00:05:03,280 --> 00:05:10,040 +acutemyelocytic leukemia الخلية الشائعة هنا اللي + +69 +00:05:10,040 --> 00:05:13,160 +هي الـ Bromielocyte with heavy azorophilic + +70 +00:05:13,160 --> 00:05:17,320 +granulation بلاقي فيها كمية كبيرة جدا من الـ + +71 +00:05:17,320 --> 00:05:21,380 +azorophilic granules والـ granules تبقى فيها كبيرة + +72 +00:05:21,380 --> 00:05:26,920 +وواضحة ممكن اللي ألاقي فيها our roots بكمية كبيرة + +73 +00:05:26,920 --> 00:05:30,960 +وملحوظة لدرجة إنها بتعمل our root bundles حزم من + +74 +00:05:30,960 --> 00:05:34,000 +الـ our roots وهذه بتعمل confirmation للـ + +75 +00:05:34,000 --> 00:05:38,690 +diagnosisفي variant منها ممكن ألاقي الـ granules + +76 +00:05:38,690 --> 00:05:45,770 +فيها small وثمينتها قليلة يعني الـ M3 variant لكن + +77 +00:05:45,770 --> 00:05:48,990 +ال common اللي هي الـ raw myelocyte with heavy + +78 +00:05:48,990 --> 00:05:53,870 +granulation هذه بيسميها M3 نيجي للـ M4 acute + +79 +00:05:53,870 --> 00:05:59,630 +myelomonocytic هذه زي الـ M2 يعني بلاقي فيها + +80 +00:05:59,630 --> 00:06:04,910 +myeloidمع الـ Maturation، آه لكن بلاقي كمان أكتر + +81 +00:06:04,910 --> 00:06:09,650 +من 20% Bromonocyte and Monocyte يعني مش .. لا + +82 +00:06:09,650 --> 00:06:12,890 +تقتصر على الـ Myeloid cells اللي هي الـ Myeloblast + +83 +00:06:12,890 --> 00:06:15,450 +و الـ Bromyelocyte و الـ Myelocyte و الـ + +84 +00:06:15,450 --> 00:06:18,810 +Metamyelocyte، لأ بلاقي فيها Other بلاقي فيها + +85 +00:06:18,810 --> 00:06:21,890 +Stages أخرى من الـ Monocytic Maturation عشان هي + +86 +00:06:21,890 --> 00:06:26,730 +قسمها قطيوت Myelomonocytic يعني بلاقي فيها Myeloid + +87 +00:06:26,730 --> 00:06:31,940 +cells و بلاقي فيها Monocytic cellsالـ M5 بتتميز + +88 +00:06:31,940 --> 00:06:38,760 +بإنها monocytic طبعاً في منها two variant M5A + +89 +00:06:38,760 --> 00:06:44,240 +بلاقي 80% منها monoblast is poorly differentiated + +90 +00:06:44,240 --> 00:06:49,280 +M5B بلاقي فيها 80% monoblast pro monocyte or + +91 +00:06:49,280 --> 00:06:52,820 +monocyte is well differentiated يعني بفرقوا عن بعض + +92 +00:06:52,820 --> 00:06:59,880 +إنه هذي بس بلاقي فيها monoblast لكن الـ5P بلاقي + +93 +00:06:59,880 --> 00:07:03,640 +فيها other maturation stage من الـ monocytic + +94 +00:07:03,640 --> 00:07:06,720 +series بلاقي monoplast, promonocyte وممكن ألاقي + +95 +00:07:06,720 --> 00:07:14,300 +monocyte الـ M6 acute erythrocytic leukemia طبعا + +96 +00:07:14,300 --> 00:07:19,620 +بلاقي تقريبا أكتر من 50% من الـ nucleated cells + +97 +00:07:19,620 --> 00:07:23,960 +with multinucleated form and cytoplasmic bridging + +98 +00:07:23,960 --> 00:07:29,990 +هنا بلاقي أن الخلية نفسهاDisplastic يعني شكلها مش + +99 +00:07:29,990 --> 00:07:36,510 +طبيعي بذر شاب شكلها مش منتظم بلاقي فيها nucleus + +100 +00:07:36,510 --> 00:07:40,010 +أحيانا عاملة multi-nucleation بلاقي الـ cytoplasm + +101 +00:07:40,010 --> 00:07:43,430 +عامل بعض الـ abnormalities المييلو بلاست ممكن أشوف + +102 +00:07:43,430 --> 00:07:47,910 +فيها مييلو بلاست فوق الـ 30% إذن هذه الخلايا اللي + +103 +00:07:47,910 --> 00:07:51,490 +قلنا عنها Displastic nucleated red cells أصلها + +104 +00:07:51,490 --> 00:07:54,970 +Erythroid عشان هي أجه اسمها acute erythrocytic + +105 +00:07:54,970 --> 00:08:00,580 +leukemiaالـ M7 ميجالو بلاستيك أنيميا هذه عادة + +106 +00:08:00,580 --> 00:08:04,260 +بلائق heterogeneous blast population with + +107 +00:08:04,260 --> 00:08:08,700 +cytoplasmic clips اللي هي بتاعة الـ Megakaryoblast + +108 +00:08:08,700 --> 00:08:14,420 +الخلية ميجا كاريو بلاست تميز بأنها خلية كبيرة فيها + +109 +00:08:14,420 --> 00:08:19,720 +نتوءات طالعة من الـ cytoplasm على شكل حبيبات زي + +110 +00:08:19,720 --> 00:08:25,940 +الزوائد يعنيطبعاً هذه بتعطيني platelet peroxidase + +111 +00:08:25,940 --> 00:08:35,500 +positive هذه acute megakaryocytic leukemia طيب + +112 +00:08:35,500 --> 00:08:39,580 +نيجي عليهم يعني من ناحية morphology نشوفهم أول + +113 +00:08:39,580 --> 00:08:44,060 +حاجة ال M1 ال M1 زي ما قلتلكم myeloblast without + +114 +00:08:44,060 --> 00:08:46,620 +maturation يعني بشوف في ال blood film بس + +115 +00:08:46,620 --> 00:08:50,410 +myeloblastوهذا الفيلم لو أنا شفته في بعض الأحيان + +116 +00:08:50,410 --> 00:08:54,490 +ممكن أقول M0 أو M1 طب إيش اللي بيخليني أقول M0 أو + +117 +00:08:54,490 --> 00:08:59,490 +M1؟ وجود الأول رد هنا بيقول إنها M1 مش M0 لو مش + +118 +00:08:59,490 --> 00:09:02,710 +موجود الأول رد لازمني أعمل Myeloperoxidase إذا + +119 +00:09:02,710 --> 00:09:06,090 +طلعت positive غالبا بتكون M1 إذا طلعت negative + +120 +00:09:06,090 --> 00:09:11,710 +بتكون M0 The Bomber هلاقي فيه أكتر من 90% blast + +121 +00:09:11,710 --> 00:09:16,670 +and less than 10% bromielocyte يعني ال most common + +122 +00:09:16,670 --> 00:09:26,560 +اللي هيالمشكلة تحصل في الكبار أكثر منها في الأصغر + +123 +00:09:26,560 --> 00:09:36,060 +سناً هاي الأول رد واضح في الخلايا شايفينه هذه + +124 +00:09:36,060 --> 00:09:42,540 +العصية الصغيرة طيب + +125 +00:09:42,540 --> 00:09:45,700 +نيجي لل AML M2 + +126 +00:09:47,840 --> 00:09:52,800 +myeloplastic with maturation قلنا هذه بلاقي فيها + +127 +00:09:52,800 --> 00:09:56,520 +myeloplast myelocyte myelocyte myelocyte myelocyte + +128 +00:09:56,520 --> 00:09:58,200 +myelocyte myelocyte myelocyte myelocyte myelocyte + +129 +00:09:58,200 --> 00:09:58,200 +myelocyte myelocyte myelocyte myelocyte myelocyte + +130 +00:09:58,200 --> 00:09:58,400 +myelocyte myelocyte myelocyte myelocyte myelocyte + +131 +00:09:58,400 --> 00:10:00,060 +myelocyte myelocyte myelocyte myelocyte myelocyte + +132 +00:10:00,060 --> 00:10:00,940 +myelocyte myelocyte myelocyte myelocyte myelocyte + +133 +00:10:00,940 --> 00:10:01,520 +myelocyte myelocyte myelocyte myelocyte myelocyte + +134 +00:10:01,520 --> 00:10:03,620 +myelocyte myelocyte myelocyte myelocyte myelocyte + +135 +00:10:03,620 --> 00:10:04,660 +myelocyte myelocyte myelocyte myelocyte myelocyte + +136 +00:10:04,660 --> 00:10:06,580 +myelocyte myelocyte myelocyte myelocyte myelocyte + +137 +00:10:06,580 --> 00:10:12,160 +myelocyte myelocyte + +138 +00:10:15,450 --> 00:10:19,550 +فيها كرمزوم الـ Translocation ما بين تمانية و واحد + +139 +00:10:19,550 --> 00:10:23,770 +و عشرين كرمزوم تمانية و كرمزوم واحد و عشرين زي ما + +140 +00:10:23,770 --> 00:10:31,490 +انتوا شايفين فينا Blast Cells تمام و فينا mature + +141 +00:10:31,490 --> 00:10:35,110 +neutrophil Hypogranulated Polymorphon Nuclear + +142 +00:10:35,110 --> 00:10:38,370 +Leukocytes يعني فيها Hypogranulation فهذه من + +143 +00:10:38,370 --> 00:10:40,470 +علامات الـ Displastic Maturation + +144 +00:10:45,250 --> 00:10:49,310 +This occurs in older adults برضه بتفصل في الكبار + +145 +00:10:49,310 --> 00:10:55,850 +أكتر منها في الصغار طيب + +146 +00:10:55,850 --> 00:11:03,330 +نيجي لـ M3 M3 قلنا فيها هي اللي فيها الـ + +147 +00:11:03,330 --> 00:11:07,210 +hypergranular و الـ hypogranular الـ hypergranular + +148 +00:11:07,210 --> 00:11:10,990 +براومييلوسيتك سلز طبعا هي بتتميز بوجود + +149 +00:11:10,990 --> 00:11:17,360 +البراومييلوسيتبلاقي البون مارو في أكتر من 30% + +150 +00:11:17,360 --> 00:11:24,180 +بلازد تعتبر من الأنواع الـ virulent ليش؟ لأنه لما + +151 +00:11:24,180 --> 00:11:28,820 +بياخد المريض العلاج بتبقى الخلايا تحت اللوكيميا + +152 +00:11:28,820 --> 00:11:31,800 +هذه الـ helibroma helicide يصير الـ helices أو + +153 +00:11:31,800 --> 00:11:35,480 +يصيرها destruction الخلايا هذه فيها حبيبات + +154 +00:11:35,480 --> 00:11:41,550 +الحبيبات هذه فيها مواد بتعمل coagulationand بتبعوا + +155 +00:11:41,550 --> 00:11:44,550 +fibrinolysis يعني بتشجع عملية الـ coagulation and + +156 +00:11:44,550 --> 00:11:48,030 +fibrinolysis وطبعا هذه تؤدي يعني بتنشط ال + +157 +00:11:48,030 --> 00:11:51,210 +coagulation و ال fibrinolysis هذا بيؤدي لإياش لـ + +158 +00:11:51,210 --> 00:11:54,810 +disseminated intravascular coagulation فعادة + +159 +00:11:54,810 --> 00:11:58,530 +بيتبعوا هذا bleeding و بتكون ال prognosis سيئة على + +160 +00:11:58,530 --> 00:12:06,410 +المريض عادة بتحصل في عمر متوسط 39 سنةبتتميز هذه بـ + +161 +00:12:06,410 --> 00:12:09,770 +Translocation 15 إلى 17 بـ chromosomal + +162 +00:12:09,770 --> 00:12:15,050 +translocation هذه الخلايا الـ Bromoylocyte فيها + +163 +00:12:15,050 --> 00:12:20,290 +أزوروفيليك جرانيول زي ما انتوا شايفين هيها والـ + +164 +00:12:20,290 --> 00:12:25,090 +granules فيها كتير واضحة طيب نيجي للنوع التاني + +165 +00:12:25,090 --> 00:12:28,170 +اللي هو الـ Hypogranular Bromoylocyte leukemia + +166 +00:12:28,170 --> 00:12:33,630 +بتتميز بوجود Bromoylocyte بس الـ Bromoylocyte هذه + +167 +00:12:34,110 --> 00:12:39,910 +hypogranular يعني الـ granules فيها قليلة و بتشكل + +168 +00:12:39,910 --> 00:12:42,950 +ال blast فيها تلقى اكتر من 30% في ال bone marrow + +169 +00:12:42,950 --> 00:12:47,670 +نفس الاشي ممكن العلاج يتسبب بال DIC و فيها + +170 +00:12:47,670 --> 00:12:54,370 +translocation 15-17 chromosomal translocation هاي + +171 +00:12:54,370 --> 00:13:01,070 +الخلايا bromielocyte بس الـ granules عيطها fine M4 + +172 +00:13:01,070 --> 00:13:07,710 +AML M4م4 زي ما حكينا هي acute myelomonoplastic + +173 +00:13:07,710 --> 00:13:12,990 +leukemia acute myelomonoplastic يعني فيها myeloid + +174 +00:13:12,990 --> 00:13:19,790 +precursors و monoplastic precursors طبعا هذه ال + +175 +00:13:19,790 --> 00:13:22,610 +precursors بشوفها سواء في الـ bone marrow أو في + +176 +00:13:22,610 --> 00:13:28,530 +البرفرال إبلط دايما لما يكون في الـ leukemia + +177 +00:13:28,530 --> 00:13:33,430 +monocytic precursorsهذه الـ Monocytic Precursors + +178 +00:13:33,430 --> 00:13:37,410 +لها القدرة على إنها تعمل Infiltration في الـ body + +179 +00:13:37,410 --> 00:13:41,470 +تشوف في أماكن خارج Extra Medullary Sites يعني ممكن + +180 +00:13:41,470 --> 00:13:45,890 +تعمل Infiltration في أماكن مختلفة من الجسم أكتر من + +181 +00:13:45,890 --> 00:13:48,950 +اللي هي الـ Granulocytic Types تشوفين الـ + +182 +00:13:48,950 --> 00:13:53,610 +Monocytic Precursors موجودة هنا بشكل واضح + +183 +00:13:53,610 --> 00:13:58,710 +Monoblast هدول Monoblast وهدول اللي فيهم Fisher + +184 +00:13:58,710 --> 00:14:03,820 +Bro Monocytesالـ M5 طبعاً بتتميز بإنها acute + +185 +00:14:03,820 --> 00:14:09,260 +monoplastic leukemia أكتر من 80% من الـ non + +186 +00:14:09,260 --> 00:14:12,800 +-erythroid cells عبارة عن monoplastic و monocytic + +187 +00:14:12,800 --> 00:14:13,640 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +188 +00:14:13,640 --> 00:14:13,980 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +189 +00:14:13,980 --> 00:14:14,540 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +190 +00:14:14,540 --> 00:14:14,620 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +191 +00:14:14,620 --> 00:14:14,760 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +192 +00:14:14,760 --> 00:14:23,340 +«مونوبلاستيك» «مونوبلاستيك» «مونوبلاستيك» + +193 +00:14:23,340 --> 00:14:26,980 +«مونوبلاستيك» «م + +194 +00:14:30,680 --> 00:14:34,500 +This form is further is divided into تنقسم إلى + +195 +00:14:34,500 --> 00:14:42,540 +نوعين M5A و M5B M5A عبارة عن purely differentiated + +196 +00:14:42,540 --> 00:14:47,760 +leukemia كيف يعني؟ هلاقي أكتر من 80% من الخلايا + +197 +00:14:47,760 --> 00:14:54,220 +monoblast M5B والـ differentiated الـ 80% هدول + +198 +00:14:54,220 --> 00:15:00,060 +هتلاقي منهم monoblast promonocyte و monocyte تمام؟ + +199 +00:15:04,410 --> 00:15:09,890 +هنا M5A أعتقد يعني هذي لأنه اللي موجودين بس Blast + +200 +00:15:09,890 --> 00:15:14,810 +اعتبرت M5A ليش عندي other stages من الـ Monocyte + +201 +00:15:14,810 --> 00:15:22,250 +التي رزقها هذي M5B لأنه موجود فيها Monoblast موجود + +202 +00:15:22,250 --> 00:15:28,830 +فيها Bromonocyte عشان أحط المؤشر بس موجود فيها + +203 +00:15:28,830 --> 00:15:33,970 +Monoblast موجود فيها Bromonocytehybromonocyte اللي + +204 +00:15:33,970 --> 00:15:37,230 +بتتميز بوجود single fissure في الخلية موجود فيها + +205 +00:15:37,230 --> 00:15:42,230 +mature monocyte علشان هيك بنعتبرها M5B الـ M6 + +206 +00:15:42,230 --> 00:15:47,370 +طبعاً بيسميها erythrochemia لأنه بتتميز بإن الـ + +207 +00:15:47,370 --> 00:15:49,890 +erythroblast بتلاقيها predominant في الـ bone + +208 +00:15:49,890 --> 00:15:53,770 +marrow وزي ما قلتلكم الخلايا بتلاقيها this plastic + +209 +00:15:53,770 --> 00:15:58,110 +يعني في abnormality في ال maturation الخلايا شوفوا + +210 +00:15:58,110 --> 00:16:01,630 +كيف ان هو يعني فيها segmentation طبعا هذا حاجة + +211 +00:16:01,630 --> 00:16:07,150 +abnormalطبعاً إلها تلت مراحل من ناحية الـ + +212 +00:16:07,150 --> 00:16:09,950 +Morphology المرحلة الأولى إني بلاقي Abnormal + +213 +00:16:09,950 --> 00:16:13,770 +Normoblast موجودة بكمية كبيرة هذه المرحلة الأولى + +214 +00:16:13,770 --> 00:16:18,750 +المرحلة التانية Erythroluchemia هيصير زيادة في الـ + +215 +00:16:18,750 --> 00:16:23,290 +Erythroblast و الـ Myeloblast ممكن تتطور للمرحلة + +216 +00:16:23,290 --> 00:16:26,390 +التالتة إنها تتحول لـ Myeloblastic Leukemia تتصير + +217 +00:16:26,390 --> 00:16:32,570 +M1 أو M2 أو M4 تمام هذه هي المراحل بتاعة الـ M6 + +218 +00:16:33,480 --> 00:16:37,420 +طبعاً شاقع فيها الأنيميا لأنه هي أساساً بتضرب الـ + +219 +00:16:37,420 --> 00:16:40,360 +Erythroid precursors شايفين كلها هذه Erythroid + +220 +00:16:40,360 --> 00:16:47,380 +precursors الـ + +221 +00:16:47,380 --> 00:16:53,300 +M7 طبعاً الـ M7 بتميز بإنها acute megakaryoblastic + +222 +00:16:53,300 --> 00:16:58,420 +leukemia عبارة عن rare disorder بتميز بـ extensive + +223 +00:16:58,420 --> 00:17:03,530 +proliferation of megakaryoblast اللي هيوجود برضه a + +224 +00:17:03,530 --> 00:17:09,030 +typical megakaryocyte and thrombocytopenia الخليط + +225 +00:17:09,030 --> 00:17:13,830 +الـ Megakaryoblast هذه هي بتتميز بأن الـ cytoplasm + +226 +00:17:13,830 --> 00:17:17,570 +بتاعها قليل وغامق كتير وفيه نتوقات أو بروزات على + +227 +00:17:17,570 --> 00:17:26,050 +شكل plebs موجودة حوالين الخلية يعني + +228 +00:17:26,050 --> 00:17:31,650 +جيلة جزئية الـ cytochemistry الأصبافالأساسية اللي + +229 +00:17:31,650 --> 00:17:34,390 +بنستخدمها الـ Special Stains اللي بنستخدمها عشان + +230 +00:17:34,390 --> 00:17:37,850 +نميز بين أنواع اللوكيميا زي ما قلنا إن اللوكيميا + +231 +00:17:37,850 --> 00:17:41,450 +لازم أستخدم إلها Special Stains عشان أتميز عند + +232 +00:17:41,450 --> 00:17:44,970 +الخلايا عن بعض لأن أحيانًا كتير الـ Blast بيكون + +233 +00:17:44,970 --> 00:17:48,690 +صعب جدًا أفصل يعني أفصلها، بيبقى تشابه كتير كتير + +234 +00:17:48,690 --> 00:17:51,950 +فيها خاصة في حالات اللوكيميا فبيكون من الصعوبة + +235 +00:17:51,950 --> 00:17:54,510 +بمكان أني أفصلها عن بعض عشان هيك أنا بستخدم + +236 +00:17:54,510 --> 00:17:57,430 +Special Stain أو اللي بسميه Cytochemistry + +237 +00:17:58,010 --> 00:18:01,410 +cytochemistry لأن التفاعل الكيميائي بيصير في داخل + +238 +00:18:01,410 --> 00:18:09,990 +الخلية طيب بداية بدي أفصل ال-AML عن ال-ALL أستخدم + +239 +00:18:09,990 --> 00:18:12,990 +الـmyelobroxidase أحنا عارفين أن الـmyeloid + +240 +00:18:12,990 --> 00:18:16,590 +والـmonocytic precursors هأخدوا بالكم الـmyeloid + +241 +00:18:16,590 --> 00:18:19,890 +والـmonocytic بتحتوي على الـmyelobroxidase + +242 +00:18:19,890 --> 00:18:23,390 +فبالتالي هتعطيني positive بينما الـlymphoid + +243 +00:18:23,390 --> 00:18:29,740 +هتعطيني negative تمام؟واللي بعمل يعني و اللي بيدعم + +244 +00:18:29,740 --> 00:18:32,420 +هذه الصبغة أو بيأكدها أو بيعمللها confirmation + +245 +00:18:32,420 --> 00:18:35,980 +برضه هي إن تطلع معايا نتائج مش كتير واضحة بالـ + +246 +00:18:35,980 --> 00:18:40,060 +Myelobroxidase أو يعني في شك فيها ممكن أؤكد نتيجتي + +247 +00:18:40,060 --> 00:18:43,080 +بالـ Sudan Blot Sudan Blot بيعطيني نفس نتائج + +248 +00:18:43,080 --> 00:18:47,800 +Myelobroxidase بيعطيني في الـ AML positive وفي ال + +249 +00:18:47,800 --> 00:18:52,160 +ALL بيعطيني negative تمام؟ إذا نرجع تاني + +250 +00:18:52,160 --> 00:18:57,070 +Myelobroxidase تعطيني positive في الـ acuteMyeloid + +251 +00:18:57,070 --> 00:19:00,350 +Leukemia يعني بالـ Myeloid Cell و بالـ Monocytic + +252 +00:19:00,350 --> 00:19:04,110 +Cell بينما في الانفايد بتعطيني Negative طيب في + +253 +00:19:04,110 --> 00:19:08,490 +خالة الـ Myeloperoxidase بتعطيني فيها Negative في + +254 +00:19:08,490 --> 00:19:13,490 +الـ AML إيش هي قلناها اللي هي الـ M0 لأن لسه + +255 +00:19:13,490 --> 00:19:17,010 +الإنزايم بيكونش متكون لدرجة إنه يقدر يعطيني + +256 +00:19:17,010 --> 00:19:20,270 +Positive Reaction Visible أقدر أشوفه فبالتالي الـ + +257 +00:19:20,270 --> 00:19:25,720 +M0 هتعطيني AML Negative و ALL Negativeهذه الملاحظة + +258 +00:19:25,720 --> 00:19:31,020 +مهمة الـ MZ روح تعطيني في التنتين negative طيب، + +259 +00:19:31,020 --> 00:19:35,960 +الآن احنا فصلنا إذا كانت مثلا acute myeloid والـ + +260 +00:19:35,960 --> 00:19:39,960 +acute lymphocytic leukemia طبعا، بس ما فصلنا الـ + +261 +00:19:39,960 --> 00:19:42,920 +myeloid عن الـ monocyte بنيجي بالـ non-specific + +262 +00:19:42,920 --> 00:19:47,380 +stress الـ non-specific stress بتفصل ليه؟الـ + +263 +00:19:47,380 --> 00:19:51,620 +Myelite بتعطيني Negative Non-specific stress بينما + +264 +00:19:51,620 --> 00:19:55,200 +الـ Monocytic اللي هي فيها M4 و M4 فيها Monocytic + +265 +00:19:55,200 --> 00:19:59,940 +cells هتعطيكي Non-specific stress Positive تمام؟ + +266 +00:19:59,940 --> 00:20:04,000 +إذن الـ Non-specific stress فصلي الـ Myelite عن + +267 +00:20:04,000 --> 00:20:06,280 +الـ Monocytic الـ Monocytic بتعطيني Positive + +268 +00:20:06,280 --> 00:20:09,200 +الميليت في الـ Non-specific stress بتعطيني Ash + +269 +00:20:09,200 --> 00:20:15,140 +بتعطيني Negative طيب بعد هيك بنيجي للـ BAS الـ BAS + +270 +00:20:16,990 --> 00:20:21,790 +الـ BAS عادة بتعطيني positive في الـ lymphoid الـ + +271 +00:20:21,790 --> 00:20:24,450 +common أن الـ BAS بتعطيني positive في الـ lymphoid + +272 +00:20:24,450 --> 00:20:30,510 +بالإضافة للـ M6 من الـ myeloid تعطيني يعني للـ + +273 +00:20:30,510 --> 00:20:32,970 +lymphoid precursor و للـ erythroid precursor + +274 +00:20:32,970 --> 00:20:39,270 +بتعطيني positive لـ M6 و لـ ALL طيب نيجي للـ acid + +275 +00:20:39,270 --> 00:20:44,410 +phosphatase الـ acid phosphatase عادة بيعطيني في + +276 +00:20:44,410 --> 00:20:49,370 +الـ AML negativeوفي الـ ALL في الـ T cell acute + +277 +00:20:49,370 --> 00:20:53,730 +lymphocytic leukemia هيعطيكي positive اللي هو مين؟ + +278 +00:20:53,730 --> 00:20:56,450 +الـ acid phosphatase إذا كنتوا فاكرين أكتر حاجة + +279 +00:20:56,450 --> 00:21:00,450 +استخدمناها للفصل أو تمييز الهيريس اللوكيميا + +280 +00:21:00,450 --> 00:21:05,550 +الهيريس اللوكيميا طيب acute lymphoblastic leukemia + +281 +00:21:05,550 --> 00:21:10,550 +reactivity with specialists تمام؟ هلاقيت الـ L1 + +282 +00:21:10,550 --> 00:21:14,940 +تعطيني بالبيروكسيداز أو Sudan black negativeالـ + +283 +00:21:14,940 --> 00:21:18,920 +Non-specific stress نيجاتيف الـ BAS positive زي ما + +284 +00:21:18,920 --> 00:21:23,400 +قولنا الـ BAS بالقلب بالمفايد بتعطيني positive الـ + +285 +00:21:23,400 --> 00:21:27,780 +2 نفس الأشياء والقلب الـ 3 نفس الأشياء لكن هنا في + +286 +00:21:27,780 --> 00:21:32,040 +عندي exception بدنا ناخد بالنا منه يعني هو هنا الـ + +287 +00:21:32,040 --> 00:21:36,560 +peroxidase are sudan black ماشي طبقنا عليهم هم بس + +288 +00:21:36,560 --> 00:21:41,260 +هنا في exception للـ sudan black الـ L3 بتتميز + +289 +00:21:41,260 --> 00:21:43,920 +الخلايا بتاعتها إنها vaculated إذا كنتوا فاكدينا + +290 +00:21:44,200 --> 00:21:46,940 +وقلنا إيش سبب الـ vacuoles سبب الـ vacuoles يعني + +291 +00:21:46,940 --> 00:21:51,280 +إنه فيه fat في قلب الخلية ولمّا أنا بحط الكحول للـ + +292 +00:21:51,280 --> 00:21:55,080 +fixation بتدوب الـ fat هذه وبتترك مكانها فجوات الـ + +293 +00:21:55,080 --> 00:21:59,900 +sudan black صبغة مخصصة لصبارة الـ fat فبالتالي + +294 +00:21:59,900 --> 00:22:03,800 +أكيد هتعطيني positive مع الـ L3 ليش؟ لأن الخلية + +295 +00:22:03,800 --> 00:22:06,700 +فيها fat فبالتالي يعتبر الـ sudan black هنا + +296 +00:22:06,700 --> 00:22:10,420 +exception لـ L البركتينفعمة أو L3 لأنه يعطي معاها + +297 +00:22:10,420 --> 00:22:13,810 +positiveتمام؟ exception الوحيد اللي هو السودان + +298 +00:22:13,810 --> 00:22:23,690 +black positive في الـ L3 بأكتب عن نقطة هذه نيجي + +299 +00:22:23,690 --> 00:22:27,770 +للـ Immunophenotyping الـ Immunophenotyping + +300 +00:22:27,770 --> 00:22:32,030 +بيستخدم بشكل يعني أكتر وبشكل أساسي للتمييز بين + +301 +00:22:32,030 --> 00:22:37,390 +أنواع الـ B والـT لمفوسايت والدرجة ال maturation + +302 +00:22:37,390 --> 00:22:42,070 +لإلها الـ A بالنسبة للخلايا أووالتباعت بتعتمد على + +303 +00:22:42,070 --> 00:22:46,770 +إيش؟ إن الخلايا خلال الـ maturation لإلها بتتميز + +304 +00:22:46,770 --> 00:22:49,270 +عليها الـ CDs اللي هي الـ clusters of + +305 +00:22:49,270 --> 00:22:53,530 +differentiation طبعا هذه كل مرحلة من مراحل الـ + +306 +00:22:53,530 --> 00:22:58,010 +maturation بتاع الخلية بتميز وجود CDs مختلفة عن + +307 +00:22:58,010 --> 00:23:01,710 +المرحل اللي قبلها فمن خلال معرفتنا لنوع الـ CD + +308 +00:23:01,710 --> 00:23:05,290 +الموجود على سطح الخلية نقدر نعرف أي stage من + +309 +00:23:05,290 --> 00:23:10,850 +الخلية وصلالهاليش؟ لأنه الـ … يعني ممكن بتلاحظوا + +310 +00:23:10,850 --> 00:23:14,770 +في الـ … في الـ lymphocytic maturation مافيش عندي + +311 +00:23:14,770 --> 00:23:18,670 +هالـ morphological changes اللي ممكن ألاحظها زي + +312 +00:23:18,670 --> 00:23:21,670 +الـ Myeloid الـ Myeloid كنا نقدر نميز كتير الـ + +313 +00:23:21,670 --> 00:23:24,730 +Myeloblast عن الـ Bromielocyte عن الـ لكن الـ + +314 +00:23:24,730 --> 00:23:28,250 +lymphocyte من lymphoblast و Bromielocyte الـ + +315 +00:23:28,250 --> 00:23:31,850 +mature lymphocyte كتير في تقارب بالـ بالـ + +316 +00:23:31,850 --> 00:23:34,950 +morphology لإلهم فاحنا بدنا نلجأ لطريقة أخرى + +317 +00:23:34,950 --> 00:23:39,740 +للتمييزوطبعاً طريقة دقيقة وبتميز عندى في أي مرحلة + +318 +00:23:39,740 --> 00:23:43,160 +أو بتحدد عندى في أي مرحلة الخلية من الـ Maturation + +319 +00:23:43,160 --> 00:23:48,480 +الهدد تعتمد على أنه أنا بدور على CD معين مثلا Body + +320 +00:23:48,480 --> 00:23:52,800 +Flow Labeled Antibody بـ Fluorescence إذا كان رطبط + +321 +00:23:52,800 --> 00:23:55,840 +الخلية بهذا Labeled Antibody طبعاً فيه direct و + +322 +00:23:55,840 --> 00:23:58,600 +indirect هحكيهم بالـ Slider اللي بعدها عشان في + +323 +00:23:58,600 --> 00:24:02,700 +رسمة بالتوضيح هحكيهم بالتفصيللكن أنا بشكل أساسي + +324 +00:24:02,700 --> 00:24:05,820 +بدور على ماركر معين بضيفله antibody labelled ب + +325 +00:24:05,820 --> 00:24:10,240 +fluorescence إذا ارتبط فيه، هيعطيني واميد الآن + +326 +00:24:10,240 --> 00:24:15,620 +بمرر الخلايا هذه على ال flow cytometer فهيعد + +327 +00:24:15,620 --> 00:24:19,280 +الخلايا اللي هي labelled بال fluorescence ويحدد + +328 +00:24:19,280 --> 00:24:22,400 +مين الخلايا ال positive لهذا ال marker ومين + +329 +00:24:22,400 --> 00:24:26,040 +الخلايا ال negative بالنسبة لل principle، هشرحها + +330 +00:24:26,040 --> 00:24:31,220 +في ال slide ده في عندي directأو Indirect Labeling + +331 +00:24:31,220 --> 00:24:35,500 +للـ Antigen يعني أنا بدي أتخيل عندي هذه الخلية + +332 +00:24:35,500 --> 00:24:41,800 +عليها يعني Marker معين أنا بدور عليها بشوف هل الـ + +333 +00:24:41,800 --> 00:24:45,580 +Marker هذا موجود ولا لأ بجيبله Antibody و بربطه + +334 +00:24:45,580 --> 00:24:50,260 +فيه في عندي طريقتين للشغل في طريقة Indirect اني + +335 +00:24:50,260 --> 00:24:56,100 +أنا مباشرة بجيب Antibody label ب fluorescence خاص + +336 +00:24:56,100 --> 00:25:01,840 +بهذا الـ Antigen و بربطه فيهطبعًا إذا كان ارتبط + +337 +00:25:01,840 --> 00:25:06,320 +خلاص بعد هيك بعمل Washing عشان أغزل الـ Excess من + +338 +00:25:06,320 --> 00:25:09,500 +هذا الـ Antibody الزيادة من هذا الـ Antibody بدي + +339 +00:25:09,500 --> 00:25:13,700 +أغسلها عشان ما تعملش عندي خلال في القراءة فإيش + +340 +00:25:13,700 --> 00:25:17,380 +اللي بيضل عندي؟ هيضل عندي كل الخلايا المرتبطة بالـ + +341 +00:25:17,380 --> 00:25:20,400 +Antibody label وبتم عدها من خلال جهاز + +342 +00:25:20,400 --> 00:25:25,100 +Fluocytometer هذه الطريقة إيش؟ Direct سمناها + +343 +00:25:25,100 --> 00:25:28,050 +Directلأن الـ Antibody اللي أنا استه Directly + +344 +00:25:28,050 --> 00:25:31,390 +ارتبط بالـ Antigen الطريقة التانية اللي هي + +345 +00:25:31,390 --> 00:25:35,870 +Indirect بيكون في عندي Two Antibodies واحد فيهم + +346 +00:25:35,870 --> 00:25:41,150 +بيرتبط مباشرة بالـ Antigen اللي أنا بدور عليه أو + +347 +00:25:41,150 --> 00:25:46,510 +الـ Marker اللي أنا بدور عليه الآن بيكون في عندي + +348 +00:25:46,510 --> 00:25:53,830 +Antibody للـ FC portion للـ Antibody الأولاني يعني + +349 +00:25:53,830 --> 00:25:56,650 +في عندي Primary Antibody ارتبطوالـ Secondary + +350 +00:25:56,650 --> 00:25:59,690 +Antibody راح يرتبط بالـ Primary طب فإيش هيرتبط؟ + +351 +00:25:59,690 --> 00:26:05,770 +هيرتبط بالـ FC-LALO الآن الـ Second Antibody هو + +352 +00:26:05,770 --> 00:26:11,070 +اللي label الـ Second Antibody هو اللي label فالآن + +353 +00:26:11,070 --> 00:26:16,670 +بعمل Washing بعمل بعد ال Washing يعني طبعا بشيل أي + +354 +00:26:16,670 --> 00:26:20,570 +Antibody مرتبطش يعني عندي Washing أولاني بعمله في + +355 +00:26:20,570 --> 00:26:26,160 +المرحلة هذهبشيل عندي أي Primary Antibody مرتبطش + +356 +00:26:26,160 --> 00:26:29,840 +بيبقى عندي مين اللي مرتبط الـ Primary Antibody مع + +357 +00:26:29,840 --> 00:26:31,560 +الـ Antigen هو اللي بيبقى عندي في الـ Reaction + +358 +00:26:31,560 --> 00:26:36,760 +Mixture الآن باضيف الـ Labeled Antibody Labeled + +359 +00:26:36,760 --> 00:26:40,560 +Antibody هيرتبط مع الـ Antibody اللي كان مرتبط على + +360 +00:26:40,560 --> 00:26:44,560 +سطح الخلية ويتكون عندي هذا الـ Complex الـ Complex + +361 +00:26:44,560 --> 00:26:48,640 +هذا هيمر على جهاز الـ Fluocytometer ويقرأ الـ + +362 +00:26:48,640 --> 00:26:53,310 +Fluorescence لإلهالآن برضه قبل ما أمرره الخطوة + +363 +00:26:53,310 --> 00:26:56,570 +الأخيرة لازم أعمل Washing عشان أتخلص من أي + +364 +00:26:56,570 --> 00:26:59,830 +Labelled Unbound Antibody يعني هنا في عملية + +365 +00:26:59,830 --> 00:27:03,170 +Washing مرتين أتخلص من الـ Antibody الـ Unbound في + +366 +00:27:03,170 --> 00:27:06,370 +المرحلة الأولى و أتخلص من الـ Antibody الـ Unbound + +367 +00:27:06,370 --> 00:27:10,330 +في المرحلة التانية طبعا هنا سميناها Indirect لأن + +368 +00:27:10,330 --> 00:27:14,200 +كان مائس Antibody المرتبط مباشرة بالـ Antigenأنا + +369 +00:27:14,200 --> 00:27:17,400 +قصدت الـAntibody المرتبط بالـAntibody الـPrimary + +370 +00:27:17,400 --> 00:27:20,560 +الـSecondary Antibody اللي تم قياسه مش الـPrimary + +371 +00:27:20,560 --> 00:27:25,200 +Antibody هيك بنكون أعرفنا كيف الإرتباط بيكون + +372 +00:27:25,200 --> 00:27:30,460 +Direct أو Indirect نيجي + +373 +00:27:30,460 --> 00:27:37,220 +للـTDT اللي هو Terminal Deoxydidyltransferase هذا + +374 +00:27:37,220 --> 00:27:43,410 +عبارة عن DNA بولميرازيكون موجود في الـ B و الـ T + +375 +00:27:43,410 --> 00:27:46,590 +precursors في الـ lymphoid precursors يعني في الـ + +376 +00:27:46,590 --> 00:27:52,610 +stem cells عادة بلاقيه بـ high levels في تقريبا 90 + +377 +00:27:52,610 --> 00:27:57,370 +% من حالات الـ lymphoblastic leukemia ممكن أحدده + +378 +00:27:57,370 --> 00:28:00,930 +باستخدام برضه labelled antibody وباستخدام ال flow + +379 +00:28:00,930 --> 00:28:03,610 +cytometry زي ما حكينا طوي عن ال cluster of + +380 +00:28:03,610 --> 00:28:08,510 +differentiationعدّي هفرزلكم جداول وانميز الخلايا + +381 +00:28:08,510 --> 00:28:11,990 +من خلال أشياء معينة في الشرائح القادمة هيكون + +382 +00:28:11,990 --> 00:28:14,570 +الموضوع أوضح بشكل واحد طيب، نيجي إلى + +383 +00:28:14,570 --> 00:28:18,510 +الـClassification بناء على الـ Cell Markers الـAML + +384 +00:28:18,510 --> 00:28:23,250 +والـALL حناخد أول إشي الـAML الـAML بتتميز غالبا + +385 +00:28:23,250 --> 00:28:27,850 +بوجود الـCD13 و33 هدول الاتنين بيكونوا positive + +386 +00:28:27,850 --> 00:28:33,350 +فيها بينما الـTDTnegative ليش؟ لأنها لأنه بيكون + +387 +00:28:33,350 --> 00:28:35,850 +positive في الـ lymphoid precursors ما بيكون في + +388 +00:28:35,850 --> 00:28:40,090 +الـ myeloid precursors الآن نيجي لحاجات خاصة يعني + +389 +00:28:40,090 --> 00:28:43,570 +مثلا الـ M6 بلاقي فيها الـ glycophorin A positive + +390 +00:28:43,570 --> 00:28:51,510 +تمام الـ M7 بلاقي فيها الـ CD41 و 42 و 61 positive + +391 +00:28:51,510 --> 00:28:58,090 +اللي هي الـ acute megakaryoplastic leukemia هنا + +392 +00:28:58,780 --> 00:29:05,700 +بتم يعني الـ ALL في منها Precursor B ALL في عندي B + +393 +00:29:05,700 --> 00:29:11,720 +ALL وفي عندي T Acute Lymphoblastic Leukemia طبعا + +394 +00:29:11,720 --> 00:29:15,040 +الـ Markers اللي بدنا نصنف بناء عليها اللي هي CD + +395 +00:29:15,040 --> 00:29:22,200 +CD19, 22, TDT, 10 Intracytoplasmic chains Surface + +396 +00:29:22,200 --> 00:29:29,210 +Immunoglobulin CD7, CD3والـ Morphology related to + +397 +00:29:29,210 --> 00:29:35,150 +which type الـ 1 أو الـ 2 أو الـ 3 أول حاجة لـ + +398 +00:29:35,150 --> 00:29:40,010 +Precursor B ALL في منها تلت أنواع نوع بيسموه + +399 +00:29:40,010 --> 00:29:46,650 +Common ALL Common ALL بتلاقي الـ 19 و 22 و الـ TDT + +400 +00:29:46,650 --> 00:29:51,490 +و العشرة positive تمام؟ الـ Null type بتفرق عنها + +401 +00:29:51,490 --> 00:29:55,820 +إن العشرة فيها negative CD10 فيها negativeلمّا + +402 +00:29:55,820 --> 00:29:59,600 +بيكون مش مكتوب حاجة يعني حاجة مش مميزة يعني لا + +403 +00:29:59,600 --> 00:30:02,780 +بقدر أقول ممكن تكون positive أو negative مش بشكل + +404 +00:30:02,780 --> 00:30:05,360 +منتظم يعني مش دايما positive ومش دايما negative + +405 +00:30:05,360 --> 00:30:07,860 +فبالتالي لمّا المنطقة الضباطية هذه اللي ماعليهاش + +406 +00:30:07,860 --> 00:30:11,580 +positive أو negative يعني لا تستخدم في التمييز أو + +407 +00:30:11,580 --> 00:30:16,550 +في تحديد هذه الأنواع من الـ Locateالـ Pre-B cell + +408 +00:30:16,550 --> 00:30:22,430 +الـ Pre-B cell هلاقيهم تقريبا متشابهة الـ CD10 + +409 +00:30:22,430 --> 00:30:25,170 +variable ممكن يبقى positive أو negative إيش بزيد + +410 +00:30:25,170 --> 00:30:28,950 +عليها؟ الـ Intra-cytoplasmic chain إيش هي الـ + +411 +00:30:28,950 --> 00:30:31,490 +Intra-cytoplasmic chain؟ الـ Intra-cytoplasmic + +412 +00:30:31,490 --> 00:30:36,290 +chain هو عبارة عن الـ surface immunoglobulin وهو + +413 +00:30:36,290 --> 00:30:39,370 +عمال بتصنع في داخل الـ cytoplasm يعني هو لسه ما + +414 +00:30:39,370 --> 00:30:42,990 +طلعت على فتح الخلية هنا بلاقي في الـ Pre-B cell + +415 +00:30:42,990 --> 00:30:48,440 +positiveبعدين بيجي عند الـ قولنا الـ precursor + +416 +00:30:48,440 --> 00:30:52,540 +قسمناها لتلاتة بتيجي عند الـ BALL وبتيجي عند الـ + +417 +00:30:52,540 --> 00:30:59,000 +TALL الـ BALL طبعا الـ CD10 فيها negative والـ + +418 +00:30:59,000 --> 00:31:03,380 +surface immunoglobulin negative الـ TALL فيها الـ + +419 +00:31:03,380 --> 00:31:11,400 +CD10 positive هلقيت الـ null type ممكن تكون L1 أو + +420 +00:31:11,400 --> 00:31:17,600 +L2 طبعا common ممكن تكون أي نوعالـ Null Type قلنا + +421 +00:31:17,600 --> 00:31:23,900 +L1 أو L2 الـ Pre-B برضه قد تكون L1 أو L2 الـ BALL + +422 +00:31:23,900 --> 00:31:32,220 +غالباً L3 الـ TALL TALL قلتلكم الـ CD10 فيها بتكون + +423 +00:31:32,220 --> 00:31:38,560 +Positive تتميز الـ T بالـ CD7 والـ CD3 فدول اتنين + +424 +00:31:38,560 --> 00:31:43,240 +بيكونوا Positive وممكن تكون على شكل L1 أو L2ماشي + +425 +00:31:43,240 --> 00:31:45,820 +يعني على شكل الخلايا ماخدة الـ Criteria + +426 +00:31:45,820 --> 00:31:55,700 +المورفولوجي تاعة الـ L1 أو الـ L2 طيب + +427 +00:31:55,700 --> 00:31:58,580 +نيجي إلى الـ Classification هل هي B أو T + +428 +00:31:58,580 --> 00:32:03,240 +-Lymphocyte؟ يعني بناء على الـ Markers معينة هنشوف + +429 +00:32:03,240 --> 00:32:07,880 +إذا كانت B Lineage أو T الـ B بتشكل 80% والـ T + +430 +00:32:07,880 --> 00:32:13,130 +بتشكل 20% الـ Markers اللي هنفصل من خلالهاالـ B + +431 +00:32:13,130 --> 00:32:18,310 +عادة الـ TdT بتكون فيها positive فكل ما تخلية M + +432 +00:32:18,310 --> 00:32:21,670 +mature بتكون فيها الـ TdT positive يعني في عندي في + +433 +00:32:21,670 --> 00:32:27,410 +الـ Bra B وفي عندي Common وفي عندي Pre-B يعني الـ + +434 +00:32:27,410 --> 00:32:31,530 +Bra B مرحل السابق للـ Pre-B بعدين ال mature B + +435 +00:32:31,530 --> 00:32:35,750 +هتلاقي فيهم الـ TdT positive بس في ال mature هتصير + +436 +00:32:35,750 --> 00:32:39,310 +negative لأن مع ال matureation هتلاقيها بلشات + +437 +00:32:39,310 --> 00:32:44,500 +تختفي الـ Cd19 هتلاقيها positive في كل الـB + +438 +00:32:44,500 --> 00:32:50,280 +الـCD10 positive ما عدا في الـBra B الـSurface + +439 +00:32:50,280 --> 00:32:56,040 +immunoglobulin هو احنا المفروض نقول الـCytoplasmic + +440 +00:32:56,040 --> 00:33:00,360 +immunoglobulin لأنه بظهر في مراحل الـSurface يعني + +441 +00:33:00,360 --> 00:33:04,360 +هو أول شي بظهر في الـCytoplasmic على سطح الخلية + +442 +00:33:04,360 --> 00:33:07,920 +فبالتالي الـCytoplasmic ممكن نلاقيه في الـPre-B + +443 +00:33:07,920 --> 00:33:12,850 +وفي الـMature B تمام؟بعد هيك في الـ Surface + +444 +00:33:12,850 --> 00:33:16,350 +Immunoglobulin هتلاقيه بس في الـ Mature B لأن كل + +445 +00:33:16,350 --> 00:33:19,770 +الـ Cytoplasmic طلع على سطح الخلية وصار على شكل + +446 +00:33:19,770 --> 00:33:25,010 +Surface Immunoglobulin طيب نيجي للـ T الـ T عادة + +447 +00:33:25,010 --> 00:33:28,590 +بتتميز بالـ CD7 إنها positive والـ TDT برضه + +448 +00:33:28,590 --> 00:33:35,870 +positive طبعاً في عند الـ Pre-T و Mature-Tالـ CD2 + +449 +00:33:35,870 --> 00:33:39,270 +بيفرق أن الـ Pre-T بيبقى فيها Negative والـ Mature + +450 +00:33:39,270 --> 00:33:43,350 +-T بيكون فيها Positive طبعاً هذا بالزمن في ال + +451 +00:33:43,350 --> 00:33:45,870 +classification لنوع الـ acute lymphoblastic + +452 +00:33:45,870 --> 00:33:52,870 +leukemia اللي هي B أو T lymphoblast حطيت هذه + +453 +00:33:52,870 --> 00:33:56,210 +الصورة بس عشان يعني تاخدوا فكرة إيش اللي بيصير + +454 +00:33:56,210 --> 00:33:59,970 +فعلياًهي الـ Maturation بتاع الـ B-cell قلتلكم الـ + +455 +00:33:59,970 --> 00:34:02,510 +Maturation الشكل تقريبا متشابه جدا في الـ + +456 +00:34:02,510 --> 00:34:05,490 +lymphocyte maturation فبنميز من خلال الـ markers + +457 +00:34:05,490 --> 00:34:09,350 +كل مرحلة معينة من مراحل الـ maturation تتميز ب + +458 +00:34:09,350 --> 00:34:11,790 +markers معينة يعني في ال early stages بتلاقي + +459 +00:34:11,790 --> 00:34:15,830 +الـTDT positive لكن بعد هيك بتبدأ الـTDT بتختفي في + +460 +00:34:15,830 --> 00:34:21,750 +ال mature الـHLA-DR والـCD19 بتكون positive على + +461 +00:34:21,750 --> 00:34:25,830 +طول للآخر الـCD20 في مرحلة معينة بتظهر وبعدين + +462 +00:34:25,830 --> 00:34:29,950 +بتختفيالـ CD10 برضه نفس الأشي في مراحل بتكون + +463 +00:34:29,950 --> 00:34:33,910 +موجودة فيها المراحل بتكونش الـ immunoglobulin برضه + +464 +00:34:33,910 --> 00:34:38,210 +ممكن تكون موجودة مع الـ maturation بتبدأ تظهر على + +465 +00:34:38,210 --> 00:34:41,730 +سطح الخلية، تمام؟ هي صورة تانية للـ B cell + +466 +00:34:41,730 --> 00:34:45,530 +maturation هذه بس صور توضحية يعني هي الـ + +467 +00:34:45,530 --> 00:34:49,090 +progenerator cell الخلية الأولى هتلاقي فيها الـ + +468 +00:34:49,090 --> 00:34:52,610 +TdT positive اللي بعدها اللي بعدها بعد هيك الـ TdT + +469 +00:34:52,610 --> 00:34:57,010 +بطل positiveطيب، نيجي للـ Markers مثلا هذه بتتميز + +470 +00:34:57,010 --> 00:35:04,030 +بالـ CD 3419 هذه 3419 و 10 TDT هذه هتلاقي في عندك + +471 +00:35:04,030 --> 00:35:07,630 +TDT positive زي ما قلنا اللي هي الـ Pre-B cell + +472 +00:35:07,630 --> 00:35:13,670 +فيها 19 و 10 و 20 و 22 يعني الشاهد في الموضوع أن + +473 +00:35:13,670 --> 00:35:17,630 +كل مرحلة من المراحل هذه بتتميز بـ Markers خاصة + +474 +00:35:17,630 --> 00:35:20,510 +فيها الـ Chronic Lymphocytic Leukemia و الـ Pro + +475 +00:35:20,510 --> 00:35:23,440 +-Lymphocytic Leukemia برضه إلها Markersالـ Hair + +476 +00:35:23,440 --> 00:35:26,700 +Cell Leukemia برضه إلها Markers الـ Wild Storm + +477 +00:35:26,700 --> 00:35:32,140 +Heavy Chain Disease برضه إله Markers معينة الملطب + +478 +00:35:32,140 --> 00:35:36,800 +الميلومة إلها Markers معينة هيك بتتمييز الـ B Cell + +479 +00:35:36,800 --> 00:35:41,440 +Leukemia من خلال الـ Immunophenotyping عشان نعرف + +480 +00:35:41,440 --> 00:35:45,220 +أي Stage اللي هي عاملة الخلية فيها Proliferation + +481 +00:35:45,220 --> 00:35:52,670 +الـ T Cell نفس الإشي برضه كل مرحلةمن المراحل بتاعة + +482 +00:35:52,670 --> 00:35:56,590 +الـ Maturation للـ T cell هتلاقي إلها Markers خاصة + +483 +00:35:56,590 --> 00:35:57,030 +فيها + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo.srt new file mode 100644 index 0000000000000000000000000000000000000000..b41f6356f8635261d56375e49ca632276f14587e --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo.srt @@ -0,0 +1,2030 @@ +1 +00:00:00,880 --> 00:00:04,800 +بسم الله الرحمن الرحيم محاضرتنا إن شاء الله راح + +2 +00:00:04,800 --> 00:00:08,400 +تكون Introduction to Special Hemostasis أو + +3 +00:00:08,400 --> 00:00:12,540 +Coagulation عملية + +4 +00:00:12,540 --> 00:00:18,180 +الـ Hemostasis عادة بتبدأ بحدوث جروح معين لما + +5 +00:00:18,180 --> 00:00:23,090 +بيحصل الجروح بتتكون لـ Clot الآن لما بتتكون لـ Clot + +6 +00:00:23,090 --> 00:00:26,370 +أكيد راح يصير الشغل اللي بعدها Clot Dissolution + +7 +00:00:26,370 --> 00:00:29,690 +لأن الـ Clot دي مش لازم تظل موجودة في مكانها لازم + +8 +00:00:29,690 --> 00:00:32,670 +يصير لها تحليل وإلا بيصير الـ Thrombosis بيصير + +9 +00:00:32,670 --> 00:00:37,870 +تجلطات عشان هيك تعتبر عملية الـ Hemostasis أنه + +10 +00:00:37,870 --> 00:00:41,490 +بيحدث فيها Balance ما بين Clot Formation and Clot + +11 +00:00:41,490 --> 00:00:46,110 +Dissolution موضوع الـ Hemostasis طبعاً بيساهم في + +12 +00:00:46,110 --> 00:00:51,600 +ثلاث أشياء مهمة الـ Vasculature Coagulation نحكي + +13 +00:00:51,600 --> 00:00:55,040 +بداية عن الـ Blood vessels لما بنحكي عن الـ Blood + +14 +00:00:55,040 --> 00:00:58,800 +vessels أكتر شيء بهمني فيها اللي هو الـ Endothelium + +15 +00:00:58,800 --> 00:01:04,380 +المبطن لإلها الـ Endothelium هذا الصحيح هو يعني + +16 +00:01:04,380 --> 00:01:08,800 +يُعتبر Dynamic Organ إيش يعني Dynamic Organ عبارة + +17 +00:01:08,800 --> 00:01:15,540 +عن جزء أو Organ عملي كيف يعني عملي بيقدر يتأقلم + +18 +00:01:15,540 --> 00:01:20,890 +ويغير وظيفته حسب البيئة المحيطة فيه يعني على سبيل + +19 +00:01:20,890 --> 00:01:24,670 +المثال في جروح هو بدي يتأقلم حاله إنه يسكر الجروح + +20 +00:01:24,670 --> 00:01:30,050 +فبصير يعطي أشياء تساعد على تسكير الجروح بصير يساعد + +21 +00:01:30,050 --> 00:01:33,330 +على تكوين الجلطة يساعد على البلاتلت aggregation و + +22 +00:01:33,330 --> 00:01:36,890 +adhesion بيساعد على إنه يصير vasoconstriction + +23 +00:01:36,890 --> 00:01:41,730 +بيعطي مواد تضيق لـ blood vessel الآن مافيش عندنا + +24 +00:01:41,730 --> 00:01:45,470 +جروح هو بطبيعته بيكون thromboresistant إيش يعني + +25 +00:01:45,470 --> 00:01:50,110 +thromboresistant؟ الـ Endothelial نفسه يعني مانع + +26 +00:01:50,110 --> 00:01:53,710 +لتكوين الجلطات يمنع التصاق لـ Platelet فيه عمق + +27 +00:01:53,710 --> 00:01:56,010 +وإنه يصير Platelet adhesion and aggregation + +28 +00:01:56,010 --> 00:01:59,490 +بالإضافة لإنه بيمنع عملية الـ Thrombosis فبالتالي + +29 +00:01:59,490 --> 00:02:03,770 +هو حسب البيئة المحيطة فيه هيشتغل حسب الظرف اللي هو + +30 +00:02:03,770 --> 00:02:07,430 +فيه هيغير وظيفته و هيفرز مواد مختلفة يعني هنلاقي + +31 +00:02:07,430 --> 00:02:11,530 +إنه بيفرز أشياء ممكن تعمل كـ Stimulators و أشياء + +32 +00:02:11,530 --> 00:02:15,200 +هتعمل Inhibitors في حاجات هتعمل Vasoconstriction + +33 +00:02:15,200 --> 00:02:20,240 +وفي حاجات هتعمل Vasodilation وظائف الـ Vascular + +34 +00:02:20,240 --> 00:02:24,300 +Endothelium أو بعض الأشياء اللي بيفرزها ونشوف إيش + +35 +00:02:24,300 --> 00:02:27,600 +وظيفتها زي أن مثلا الـ Prostacycline الـ + +36 +00:02:27,600 --> 00:02:30,080 +Prostacycline هذا بيعمل في الوضع الطبيعي + +37 +00:02:30,080 --> 00:02:32,560 +Vasodilation لأنه أنا بدي الـ blood vessel في الوضع + +38 +00:02:32,560 --> 00:02:36,100 +الطبيعي بدون جروح يبقى متسع و الـ blood يمشي + +39 +00:02:36,100 --> 00:02:39,840 +بأرياحية شغلة تانية Inhibition of platelet + +40 +00:02:39,840 --> 00:02:42,700 +aggregation وهذا اللي أنا بدياه بالوضع الطبيعي أنا + +41 +00:02:42,700 --> 00:02:45,840 +مابدي يصير platelet aggregation الـ Thrombocytin + +42 +00:02:45,840 --> 00:02:49,280 +A2 هذا بتكون لـ platelets بعمل construction لـ + +43 +00:02:49,280 --> 00:02:54,660 +blood vessels أو لـ muscular arteries في عندي + +44 +00:02:54,660 --> 00:02:58,900 +شغلات أخرى زي الـ ELAMs and ICAMs هذه عبارة عن + +45 +00:02:58,900 --> 00:03:05,260 +cytokines بيفرزها الـ endothelium الـ cytokines هذه + +46 +00:03:05,260 --> 00:03:09,500 +إلها علاقة في جذب الـ white bcs إلى مكان الـ + +47 +00:03:09,500 --> 00:03:13,080 +inflammation والتصاقها فيه فبالتالي هو إيه وإيه + +48 +00:03:13,080 --> 00:03:16,420 +علاقة بالـ inflammatory process الـ von و الـ brand + +49 +00:03:16,420 --> 00:03:20,520 +factor طبعا مهم جدا في التصاق لـ platelets مع الـ + +50 +00:03:20,520 --> 00:03:26,190 +subendothelial collagen الشغلات تانية ممكن يعطيها + +51 +00:03:26,190 --> 00:03:32,990 +زي الـ Tissue Factor Pathway Inhibitors في عندي زي + +52 +00:03:32,990 --> 00:03:36,530 +ما أنتم عارفين لما بتكون الـ Fibrin فالنهاية أنا + +53 +00:03:36,530 --> 00:03:39,130 +بدي أوقف عملية الـ Coagulation خلاص مابديها تظل + +54 +00:03:39,130 --> 00:03:42,390 +مستمرة للأبد لازم توقف قد وظيفته وتكون الـ Fibrin + +55 +00:03:42,390 --> 00:03:46,240 +لازم توقف العملية هذه فبالتالي بتطلع عندي مواد + +56 +00:03:46,240 --> 00:03:49,300 +بتعمل كـ Anticoagulant من الـ Anticoagulants هذه و + +57 +00:03:49,300 --> 00:03:52,120 +اللي بيساهم الـ Endothelium في تكوينها اللي هو الـ + +58 +00:03:52,120 --> 00:03:56,560 +Tissue factor Pathway Inhibitor هذا بيوقف الـ + +59 +00:03:56,560 --> 00:03:59,420 +Coagulation عن طريق توقيف الـ Extrinsic Pathway + +60 +00:03:59,420 --> 00:04:03,200 +راح نشوف لقدام كيف فيه أن الـ Thrombomodulin، + +61 +00:04:03,200 --> 00:04:05,780 +Thrombomodulin هذا بيعمل Inhibition للـ + +62 +00:04:05,780 --> 00:04:08,780 +Coagulation عن طريق الـ Activation للـ Protein C + +63 +00:04:08,780 --> 00:04:13,130 +System اللي بدوره بيوقف الـ Coagulation في عند الـ + +64 +00:04:13,130 --> 00:04:16,530 +Tissue Plasminogen Activator طبعاً الـ Plasminogen + +65 +00:04:16,530 --> 00:04:21,670 +هذا بيبدأ عملية الـ Fibrinolysis فبالتالي هو بيشجع + +66 +00:04:21,670 --> 00:04:25,050 +الـ Fibrinolysis في أن الهيبرين سلفات + +67 +00:04:25,050 --> 00:04:28,370 +البروتيوجلاكان برضه من الأشياء اللي بيفرزها هذا + +68 +00:04:28,370 --> 00:04:33,350 +بيعمل Inhibition للـ coagulation by activation of + +69 +00:04:33,350 --> 00:04:36,730 +antithrombine يعني بنشط الـ antithrombine فبالتالي + +70 +00:04:36,730 --> 00:04:40,420 +بيعمل كـ Anticoagulant بالإضافة لأنه بيعطينا الـ + +71 +00:04:40,420 --> 00:04:43,120 +tissue factor الـ tissue factor بيرتبط إلى factor + +72 +00:04:43,120 --> 00:04:49,260 +7 وبيعمل initiation للـ extrinsic pathway يعني هنا + +73 +00:04:49,260 --> 00:04:55,120 +كـ anticoagulant شغال و كـ procoagulant نيجي للـ + +74 +00:04:55,120 --> 00:04:58,380 +blood platelets البلاتلتز زي ما احنا عارفين هي + +75 +00:04:58,380 --> 00:05:02,280 +بتتكون من الـ cytoplasm للبوم مارو ميجا كاريوسايت + +76 +00:05:02,280 --> 00:05:06,080 +طبعا هي أصغر واحدة في الـ blood cells أو الـ + +77 +00:05:06,080 --> 00:05:09,500 +component elements بتاعة الـ blood الوضع الطبيعي لها + +78 +00:05:09,500 --> 00:05:15,060 +عددها يتروح ما بين 150 إلى 450 ألف شكلها disk + +79 +00:05:15,060 --> 00:05:19,320 +shape a enucleated cell with complex internal + +80 +00:05:19,320 --> 00:05:23,440 +structure يعني في تركيبها الداخل المعقد يعكس ما + +81 +00:05:23,440 --> 00:05:26,020 +تقوم به من وظيفة في الهيموستاسس + +82 +00:05:29,330 --> 00:05:33,910 +طيب لـ Platelets أهم حاجة في تركيبها اللي هي الـ + +83 +00:05:33,910 --> 00:05:36,450 +Granules اللي موجودة فيها اللي بتقوم بالوظائف + +84 +00:05:36,450 --> 00:05:38,670 +المهمة في الـ Hemostasis في عندنا الـ Alpha + +85 +00:05:38,670 --> 00:05:42,530 +Granules وفي عندنا الـ Dense Granules الـ Alpha + +86 +00:05:42,530 --> 00:05:46,350 +Granules إيش محتوياتها؟ هيكون فيها بعض الـ + +87 +00:05:46,350 --> 00:05:49,630 +Coagulation Factors زي الـ Fibrinogen، Vinyl Brand + +88 +00:05:49,630 --> 00:05:53,990 +Factor فيها الـ Coagulation Factor خمسة و ثمانية + +89 +00:05:53,990 --> 00:05:58,460 +فيها كمان Platelet Derived Growth Factor في عند الـ + +90 +00:05:58,460 --> 00:06:03,120 +Dense Granules الـ Dense Granules صميت هيك لأن هيك + +91 +00:06:03,120 --> 00:06:06,180 +بتظهر في الـ electron microscope هذه بتحتوي على + +92 +00:06:06,180 --> 00:06:09,620 +الـ ATP وبتحتوي على الـ ADP وبتحتوي على + +93 +00:06:09,620 --> 00:06:13,900 +السيروتونين الـ Granules هذه بيصيرلها release في + +94 +00:06:13,900 --> 00:06:19,140 +حالة البلاتلت activation هنا + +95 +00:06:19,140 --> 00:06:22,620 +عندنا صورة بتوضح أهم شيء يعني بتوضح تركيبة + +96 +00:06:22,620 --> 00:06:26,520 +البلاتلت أهم شيء بيهمني اللي هي الـ .. الـ .. الـ .. + +97 +00:06:26,520 --> 00:06:30,520 +الـ .. اللي هي الـ Density Granules و الـ Alpha-Granules + +98 +00:06:30,520 --> 00:06:33,920 +هيهم وهي محتوياتهم واضحين عندنا بالصورة + +99 +00:06:33,920 --> 00:06:36,940 +طيب، + +100 +00:06:36,940 --> 00:06:42,480 +نشوف الآن كيف بيصير الـ Platelet Activate خلينا + +101 +00:06:42,480 --> 00:06:46,740 +نتخيل blood vessel وعاء دموي الوعاء الدموي هذا + +102 +00:06:46,740 --> 00:06:49,960 +عادة بيكون مبطن بالـ Endothelial اللي هو الخط + +103 +00:06:49,960 --> 00:06:54,780 +الأحمر فيه تحت منه الـ Subendothelial اللي هو الخط + +104 +00:06:54,780 --> 00:06:59,220 +المتقطع الأبيض اللي باين هلقيت في الوضع الطبيعي هي + +105 +00:06:59,220 --> 00:07:01,780 +البلاد اللي تماشية في الـ blood vessel في عندي + +106 +00:07:01,780 --> 00:07:07,560 +coagulation factors في عندي يعني integral + +107 +00:07:07,560 --> 00:07:11,840 +integrated اندوثيليام شايفين كيف الاندوثيليام هنا + +108 +00:07:11,840 --> 00:07:15,340 +متكامل هلقيت صار جروح تخيلوا على الجهة التانية صار + +109 +00:07:15,340 --> 00:07:19,520 +عندي جروح الجروح هذا هيعمل exposing للـ sub + +110 +00:07:19,520 --> 00:07:24,340 +endothelial الـ sub endothelial هذا هيصير باين + +111 +00:07:24,340 --> 00:07:29,500 +وظاهر فبالتالي الآن هتبدأ عملية ارتباط لـ Platelets + +112 +00:07:29,500 --> 00:07:32,460 +بالـ Subendothelium عشان تعمل Platelet Adhesion + +113 +00:07:32,460 --> 00:07:35,720 +على الهامش، في عندي هنا Release للـ Tissue Factor + +114 +00:07:35,720 --> 00:07:38,440 +الـ Tissue Factor هنا مش هيلزمني في الـ Extrinsic + +115 +00:07:38,440 --> 00:07:43,520 +Pathway لكن هو بيقولك يعني إنه الـ Sub … برضه الـ + +116 +00:07:43,520 --> 00:07:47,820 +Endothelium بيساعد على الـ Release للـ Tissue + +117 +00:07:47,820 --> 00:07:51,560 +Factor اللي بيساعد في سيكندرية مستهزة، تمام؟ + +118 +00:07:51,560 --> 00:07:55,840 +خلينا في موضوع إنه صار جروح، صار Injury صار + +119 +00:07:55,840 --> 00:07:58,740 +Exposing للـ Subendothelial خلينا نشوف إيش بيصير + +120 +00:07:58,740 --> 00:08:03,240 +هلقيت + +121 +00:08:03,240 --> 00:08:07,060 +الجروح هيطلع عندي Von Willebrand Factor الـ Von + +122 +00:08:07,060 --> 00:08:10,340 +Willebrand Factor هذا راح يربط البلاتلت مع الـ + +123 +00:08:10,340 --> 00:08:14,860 +Subendothelial tissue كيف؟ عن طريق ريسبتر على صفح + +124 +00:08:14,860 --> 00:08:20,190 +البلاتلت اللي هو Glycoprotein 1B هذا هو اللي بتم من + +125 +00:08:20,190 --> 00:08:23,950 +خلاله ارتباط البلاتلت مع الـ Von و الـ Brand Factor + +126 +00:08:23,950 --> 00:08:28,550 +اللي بدوره بيمسك البلاتلت على الـ Subendothelial + +127 +00:08:28,550 --> 00:08:32,850 +tissue وهذه مرحلة الـ Initial Platelet Activation + +128 +00:08:32,850 --> 00:08:36,550 +بحيث أنه يصير Adhesion للبلاتلت مع الـ + +129 +00:08:36,550 --> 00:08:39,490 +Subendothelium تمام؟ إذن هي المرحلة الأولى في + +130 +00:08:39,490 --> 00:08:42,990 +مرحلة الـ Platelet Activation إنه صار لها Adhesion + +131 +00:08:42,990 --> 00:08:47,800 +بالـ Subendothelium الآن الخطوة الأولى اللي حكينا + +132 +00:08:47,800 --> 00:08:53,540 +عنها خطوة الـ Platelet Adhesion عبارة عن شغلة يعني + +133 +00:08:53,540 --> 00:08:58,640 +بدون طاقة ما بتحتاجش ATP شغل تاني reversible يعني + +134 +00:08:58,640 --> 00:09:01,400 +أنا بعتبره Inertial Adhesion المرحلة اللي بعدها + +135 +00:09:01,400 --> 00:09:04,900 +الأهم اللي هي مرحلة الـ Platelet Aggregation الـ + +136 +00:09:04,900 --> 00:09:07,920 +Platelet Aggregation ليش بيصير؟ بيصير عشان الـ + +137 +00:09:07,920 --> 00:09:11,780 +Platelet بتجمع مع بعضها وبعد ما تتجمع تروح وهي + +138 +00:09:11,780 --> 00:09:16,260 +مسكرة الجروح هي والـ Fibrinogen بيرتبطوا مع بعض و + +139 +00:09:16,260 --> 00:09:21,540 +بيسددوا الجروح زي ما عندنا راح نشوف مع بعض هلأ كيف + +140 +00:09:21,540 --> 00:09:24,920 +بتصير عملية ال activation لـ Platelet Aggregation + +141 +00:09:24,920 --> 00:09:29,340 +في عندي مجموعة Agonist هترتبط مع ال Platelets عن + +142 +00:09:29,340 --> 00:09:33,080 +طريق Receptors على سطح ال Platelets كل Agonist له + +143 +00:09:33,080 --> 00:09:36,990 +Receptor خاص فيه زي الـ Adenosine زي الـ Collagen + +144 +00:09:36,990 --> 00:09:40,610 +زي الـ Thrombin برضه كلها دي Agonist إيش هتعمل؟ + +145 +00:09:40,610 --> 00:09:45,210 +لما بترتبط هيصير عندي سلسلة من التفاعلات بينتج + +146 +00:09:45,210 --> 00:09:51,770 +عنها مجموعة شغلات إيش بينتج؟ أول حاجة بيصير تحول + +147 +00:09:51,770 --> 00:09:55,050 +للـ Arachidonic Acid عن طريق الـ Cyclooxygenase + +148 +00:09:55,050 --> 00:09:58,950 +إلى Thromboxane-A2 Thromboxane-A2 هذا بعمل + +149 +00:09:58,950 --> 00:10:02,310 +activation للـ Platelets ولما تفرز الـ Platelets + +150 +00:10:02,620 --> 00:10:06,560 +هيعمل activation لـ other platelets تمام الشغل + +151 +00:10:06,560 --> 00:10:10,560 +التاني هيصير Degranulation للـ platelets البلاتلت + +152 +00:10:10,560 --> 00:10:14,220 +هتفرز الـ granules بتاعتها طبعاً هذا بيساعد على + +153 +00:10:14,220 --> 00:10:19,540 +أنه البلاتلت التانية تصير لها activation بالإضافة + +154 +00:10:19,540 --> 00:10:22,880 +لأنه في أشياء مهمة زي الـ Fibrinogen زي هيك هذه + +155 +00:10:22,880 --> 00:10:26,980 +الأشياء الموجودة في الـ granules مهمة في عملية الـ + +156 +00:10:26,980 --> 00:10:32,080 +Hemostasis شغلة تالتة مهمة برضه بتصير اللي هي بيصير + +157 +00:10:32,080 --> 00:10:34,860 +تغير في الـ Configuration للـ Receptor اللي على + +158 +00:10:34,860 --> 00:10:37,440 +سطح البلاتلت إيش هذا الـ Receptor؟ هذا الـ + +159 +00:10:37,440 --> 00:10:44,780 +Receptor اللي هو Alpha 2B Beta 3 هذا + +160 +00:10:44,780 --> 00:10:48,460 +الـ Receptor هو اللي هيربط البلاتلت مع الـ + +161 +00:10:48,460 --> 00:10:51,700 +Fibrinogen فبيصير تغير في الـ Configuration بتاعه + +162 +00:10:51,700 --> 00:10:54,720 +بحيث أنه يصير له Activation ويرتبط مع الـ + +163 +00:10:54,720 --> 00:10:58,860 +Fibrinogen هلقيت إذن؟ الخلاصة إنه صار activation + +164 +00:10:58,860 --> 00:11:03,290 +للـ Platelet صار Degranulation صار تكون للـ + +165 +00:11:03,290 --> 00:11:07,450 +Thromboxane A2 شغل برضه مهم جداً أنه بيصير تغير في + +166 +00:11:07,450 --> 00:11:11,150 +شكل البلاتلت التغير في شكل البلاتلت فهذا بيساعد + +167 +00:11:11,150 --> 00:11:15,230 +على أنه يصير لها Adhesion مع بعض أنه مساحة + +168 +00:11:15,230 --> 00:11:19,370 +الالتصاق للبلاتلت مع بعضها تكون أوسع مما لو كانت + +169 +00:11:19,370 --> 00:11:22,630 +البلاتلت Discoid shape بتصير كأنه إصبايكي بيصير + +170 +00:11:22,630 --> 00:11:26,190 +لها نتوءات وزوائد هذه النتوءات بتزيد مساحة سطحها و + +171 +00:11:26,190 --> 00:11:30,430 +بتساعد على التشابك بيصير activation لـ «الرسيبتور» + +172 +00:11:30,430 --> 00:11:35,990 +اللي هيرتبط مع الفترة النتيجة أو المحصلة زي ما + +173 +00:11:35,990 --> 00:11:39,970 +انتوا شايفين محصلة الخطوتين اللي حكينا عنهم قبلها هيك + +174 +00:11:39,970 --> 00:11:46,610 +أنه أول حاجة البلاتلت ارتبطت بالـ Subendothelial + +175 +00:11:46,610 --> 00:11:50,470 +tissue عن طريق الـ Von Willebrand Factor في خطوة + +176 +00:11:50,470 --> 00:11:53,770 +الـ Adhesion المرحلة اللي بعدها اللي هي مرحلة الـ + +177 +00:11:53,770 --> 00:11:58,960 +Aggregation هتصير البلاتلت عاملة Bridging مع بعض عن + +178 +00:11:58,960 --> 00:12:01,840 +طريق الـ Fibrinogen طبعاً اللي بربطهم اللي هو الـ + +179 +00:12:01,840 --> 00:12:09,080 +Receptor Alpha-2B Beta-3 The cross-linking of two + +180 +00:12:09,080 --> 00:12:12,580 +or more platelets by Alpha-2B Beta-3 and + +181 +00:12:12,580 --> 00:12:15,800 +Fibrinogen is termed aggregation إذا صارت Platelet + +182 +00:12:15,800 --> 00:12:19,200 +Aggregation مع الـ Fibrinogen وهذه العملية اللي هي + +183 +00:12:19,200 --> 00:12:24,900 +هتساعد على تثبيتها برضه هنا يعني في عندي توضيح آخر + +184 +00:12:24,900 --> 00:12:29,840 +لإيش اللي بيصير اللي بيصير زي ما شوفنا إنه في عندي + +185 +00:12:29,840 --> 00:12:33,380 +مجموعة من الـ Agonist بترتبط طبعاً هذه المرحلة + +186 +00:12:33,380 --> 00:12:37,680 +مرحلة الـ Aggregation بتحتاج ATP زي ما حكينا بيصير + +187 +00:12:37,680 --> 00:12:40,400 +مجموعة من الـ Agonist بترتبط على سطح الـ Platelets + +188 +00:12:40,400 --> 00:12:43,660 +وبيصير activation لـ Platelets والـ Platelets + +189 +00:12:43,660 --> 00:12:46,360 +أساساً كانت مرتبطة بالـ Subendothelial tissue + +190 +00:12:46,360 --> 00:12:51,180 +طبعاً يعني هذا زي ملخص للكلام اللي حكيناه + +191 +00:12:55,170 --> 00:13:01,630 +طبعاً هنا هذه شريحة يعني بتحاول تربط وتبين لنا + +192 +00:13:01,630 --> 00:13:06,070 +يعني كيف ممكن البلاتلت activation برضه يأثر ويحفظ + +193 +00:13:06,070 --> 00:13:10,030 +الـ secondary pathway لقيت عملية التحفيز اللي بتصير + +194 +00:13:10,030 --> 00:13:11,970 +لها البلاتلت أو الـ activation اللي بتصير له + +195 +00:13:11,970 --> 00:13:17,470 +البلاتلت بتقدر لإنه في نديق الفوسفاتيدال سيرين فده + +196 +00:13:17,470 --> 00:13:20,460 +عبارة عن فوسفه اللي بتشحنته سالبة الـ Phospholipid + +197 +00:13:20,460 --> 00:13:24,840 +هذا راح ينتقل إلى أو يتجمع عند السطح الخارجي للـ + +198 +00:13:24,840 --> 00:13:27,980 +Cell Membrane تاع الـ Platelet فبالتالي بتصير + +199 +00:13:27,980 --> 00:13:32,260 +الشحنة بتاعة الـ Platelets سالبة فلقيت شحنة الـ + +200 +00:13:32,260 --> 00:13:37,200 +Platelets السالبة هتعمل كعامل مساعد لبداية الـ + +201 +00:13:37,200 --> 00:13:40,620 +Intrinsic Pathway مظبوط فلقيت الـ Intrinsic + +202 +00:13:40,620 --> 00:13:46,330 +Pathway اتنشط هيكون لـ Thrombin للثرومبين هيعمل من + +203 +00:13:46,330 --> 00:13:51,510 +تاني كـ Agonist يحفظ البلاتلت وهكذا حفظت البلاتلت + +204 +00:13:51,510 --> 00:13:54,230 +زادت الـ Negative Charge وزاد الـ Intrinsic + +205 +00:13:54,230 --> 00:13:58,290 +Pathway فكلها عبارة عن حلقة متكاملة كل واحد فيهم + +206 +00:13:58,290 --> 00:14:04,390 +مسؤول عن تنشيط شغلة أو شغلات كتير ننتقل للجزء + +207 +00:14:04,390 --> 0:14:07,910 +الثالث من مقونات الـ Hemostasis أو الأشياء اللي + +208 +00:14:07,910 --> 00:14:10,650 +بتساهم في حدوث الـ Hemostasis اللي هو الـ + +209 +00:14:10,650 --> 00:14:14,350 +Coagulation Factor الـ Coagulation factor بتمشي في + +210 +00:14:14,350 --> 00:14:19,650 +كسكايد بيبدأ بحدوث الجروح وينتهي بتكوين الفيبرين + +211 +00:14:19,650 --> 00:14:24,070 +في ما يسمى الـ Coagulation cascade الـ Coagulation + +212 +00:14:24,070 --> 00:14:28,470 +cascade يعني مش حاجة تم اكتشافها حديثاً وإنما هي في + +213 +00:14:28,470 --> 00:14:33,870 +ستينيات القرن الماضي حيث إنه كان يعتقد أن الـ + +214 +00:14:33,870 --> 00:14:37,110 +Clotting عملية التجلط بتحصل عن طريق مجموعة من + +215 +00:14:37,110 --> 00:14:41,640 +التفاعلات التفاعلات هذه بتبدأ بتنشيط Serine + +216 +00:14:41,640 --> 00:14:45,220 +Protease Zymogens اللي هي احنا بنحكي عنها الـ + +217 +00:14:45,220 --> 00:14:50,780 +Coagulation Factors هذه الـ Factors طبعاً بتتحول لـ + +218 +00:14:50,780 --> 00:14:54,260 +Active Enzymes خطوة ورا خطوة يعني كل واحد مسئول عن + +219 +00:14:54,260 --> 00:14:58,920 +تنشيط الـ Enzyme اللي بعده في النهاية بنتهي الـ + +220 +00:14:58,920 --> 00:15:04,100 +pathway بتكوين الفيبرين لفترات طويلة، ظل الاعتقاد + +221 +00:15:04,100 --> 00:15:06,900 +السائد إن الـ Intrinsic Pathway هو الـ more + +222 +00:15:06,900 --> 00:15:10,380 +important in clotting mechanism يعني ما كانوش ماخدين + +223 +00:15:10,380 --> 00:15:13,020 +في الحسبان موضوع الـ Tissue Factor مع Factor VII + +224 +00:15:13,020 --> 00:15:16,540 +pathway اللي هو الـ Extrinsic Pathway لكن احنا + +225 +00:15:16,540 --> 00:15:20,240 +اليوم بنقول إنهم اثنين بيمشوا side by side، جنباً + +226 +00:15:20,240 --> 00:15:25,060 +جنباً طبعاً عملية التجلط هذه أو عملية تكوين الفيبرين + +227 +00:15:25,060 --> 00:15:29,740 +بتبدأ بجروح الجروح هذا هيعمل activation للـ + +228 +00:15:29,740 --> 00:15:33,900 +Intrinsic Pathway و للـ Extrinsic Pathway تنتهي + +229 +00:15:33,900 --> 00:15:38,500 +هذه العملية في NDA الـ Coagulation Cascade خلينا + +230 +00:15:38,500 --> 00:15:42,800 +ناخد نظرة سريعة على الـ Coagulation Cascade زي ما + +231 +00:15:42,800 --> 00:15:47,340 +احنا عارفين هو عبارة عن بيمشي بطريقين بيمشي بطريق + +232 +00:15:47,340 --> 00:15:51,280 +الـ Intrinsic Pathway و Extrinsic Pathway هدول + +233 +00:15:51,280 --> 00:15:54,780 +الاثنين طبعاً بيمشوا side by side مترابطين مع بعض يعني + +234 +00:15:54,780 --> 00:15:59,390 +ما فيش فيهم واحد بيسبق الثاني جي للـ Intrinsic + +235 +00:15:59,390 --> 00:16:04,390 +Pathway الـ Intrinsic Pathway لما يصير Exposure لـ + +236 +00:16:04,390 --> 00:16:08,730 +Sub-endothelial Collagen هيعمل activation لـ + +237 +00:16:08,730 --> 00:16:12,610 +Factor 12 في وجود هيعمل activation لـ Factor 12 + +238 +00:16:12,610 --> 00:16:15,370 +الـ Factor 12 Active مع الـ Pre-Kallikrein والـ + +239 +00:16:15,370 --> 00:16:17,890 +High Molecular Weight Kininogen هيعملوا + +240 +00:16:17,890 --> 00:16:22,480 +activation لـ Factor 11 أول فاكتور حكينا عنه في الـ + +241 +00:16:22,480 --> 00:16:26,060 +Intrinsic فاكتور 12 بعدين فاكتور 11 بعد هيك + +242 +00:16:26,060 --> 00:16:29,720 +هيعملوا activation لفاكتور 9 تمام؟ هيعملوا + +243 +00:16:29,720 --> 00:16:33,800 +activation لفاكتور 9 المرحلة اللي بعدها اللي هي الـ + +244 +00:16:33,800 --> 00:16:37,200 +activation لفاكتور 10 هلقيت الـ activation لفاكتور + +245 +00:16:37,200 --> 00:16:42,840 +10 بيصير عن طريق فاكتور 8 Active فاكتور 8 Active + +246 +00:16:42,840 --> 00:16:46,000 +مع الـ Platelet Phospholipid مع الكالسيوم مع + +247 +00:16:46,000 --> 00:16:50,730 +الكالسيوم اللي هو فاكتور 4 فهدول بيقبو يسيي يعني + +248 +00:16:50,730 --> 00:16:54,070 +بيعملوا ما يسمى بالـ Tenase Complex تينيس كمبليكس + +249 +00:16:54,070 --> 00:16:57,530 +بعمل activation لفاكتور عشرة عشان نبدأ الـ Common + +250 +00:16:57,530 --> 00:17:01,530 +pathway بينما الـ Extrinsic Pathway برضه نتيجة + +251 +00:17:01,530 --> 00:17:04,790 +الجروح بيتكون عندي الـ Tissue Factor + +252 +00:17:04,790 --> 00:17:08,970 +بيرتبط مع Factor 7 بيصير Activation لـ Factor 7 + +253 +00:17:08,970 --> 00:17:12,410 +Tissue Factor Factor 7 active مع الـ Platelet + +254 +00:17:12,410 --> 00:17:16,030 +Phospholipid هدول هيقوموا بدور الـ Complex + +255 +00:17:16,030 --> 00:17:21,190 +بحيث أنه هيعمل Activation مباشرة لـ Factor 10 إذن + +256 +00:17:21,190 --> 00:17:24,210 +Factor 10 صار له Activation بطريقين إما بالـ + +257 +00:17:24,210 --> 00:17:28,010 +Extrinsic Pathway أو بالـ Intrinsic Pathway الـ + +258 +00:17:28,010 --> 00:17:31,410 +Extrinsic Pathway عدينا فيه بس فاكتور 7 وشفنا فاكتور + +259 +00:17:31,410 --> 00:17:35,110 +بينما الـ Intrinsic Pathway عدينا فيه فاكتور 12 + +260 +00:17:35,110 --> 00:17:40,070 +فاكتور 11 فاكتور 9 فاكتور 8 والكالسيوم اللي هو + +261 +00:17:40,070 --> 00:17:45,290 +فاكتور 4 تمام فالإثنين سواء الـ Extrinsic Pathway أو + +262 +00:17:45,290 --> 00:17:47,730 +الـ Intrinsic Pathway اللي اتنشط من نتيجة حدوث + +263 +00:17:47,730 --> 00:17:51,990 +الجروح هيعملوا activation لـ فاكتور 10 فاللي فاكتور + +264 +00:17:51,990 --> 00:17:58,470 +10 الـ Active هو اللي هيعمل activation لـ Thrombin + +265 +00:17:58,470 --> 00:18:03,270 +يعني هو هيحول الـ Prothrombin إلى Thrombin عن طريق + +266 +00:18:03,270 --> 00:18:06,690 +اللي هو ما يسمى بالـ Prothrombinase Complex اللي + +267 +00:18:06,690 --> 00:18:09,270 +هنا طبعاً زي ما قلنا بنبدأ الـ Common Pathway الـ + +268 +00:18:09,270 --> 00:18:13,280 +Common Pathway بيبدأ لما الـ Factor X active + +269 +00:18:13,280 --> 00:18:16,780 +في وجود الـ Platelet Phospholipid وفي + +270 +00:18:16,780 --> 00:18:20,700 +وجود الـ Calcium وفي وجود Factor V active زي ما + +271 +00:18:20,700 --> 00:18:23,980 +قلنا هذا بيسمى الـ Prothrombinase Complex بيحول + +272 +00:18:23,980 --> 00:18:27,000 +عند الـ Prothrombin إلى Thrombin اللي هو إلى + +273 +00:18:27,000 --> 00:18:31,960 +Active Form الـ Thrombin هيحول الـ Fibrinogen إلى + +274 +00:18:31,960 --> 00:18:36,500 +Fibrin Monomer بعد هيك Factor XIII هيصير له + +275 +00:18:36,500 --> 00:18:40,470 +Activation الـ Factor 13 هيعمل Stabilization لـ + +276 +00:18:40,470 --> 00:18:44,690 +Fibrin Monomer وهيحوله لـ Fibrin Polymer هيك + +277 +00:18:44,690 --> 00:18:50,670 +هيتكون عندي Stable Fibrin اللي هو هيساعد على .. في + +278 +00:18:50,670 --> 00:18:54,770 +الوضع الطبيعي طبعاً في عندي Balance يعني لما بنحتاج + +279 +00:18:54,770 --> 00:18:58,890 +تكون الـ Fibrin يتكون الـ Fibrin وبيسكر الجروح بعد + +280 +00:18:58,890 --> 00:19:02,910 +هيك بتبدأ الـ Fibrinolytic activity الـ Fibrinolytic + +281 +00:19:02,910 --> 00:19:06,470 +activity بتكسر الـ Fibrin اللي اتكون عشان ما تتكونش + +282 +00:19:06,470 --> 00:19:11,130 +جلطات الآن ممكن تتكون عندي thrombus أو جلطات في + +283 +00:19:11,130 --> 00:19:16,270 +حالتين إما بيصير abnormal activation لـ + +284 +00:19:16,270 --> 00:19:19,950 +coagulation cascade يعني ما فيش داعي أنه يتنشط + +285 +00:19:19,950 --> 00:19:25,510 +ويتنشط لسبب من الأسباب فبالتالي هتتكون thrombus في + +286 +00:19:25,510 --> 00:19:30,010 +نفس الوقت ممكن يكون السبب إنه اتكونت الـ thrombus + +287 +00:19:30,010 --> 00:19:33,590 +لكن فيه خلل في الـ fibrinolytic activity يعني هذه + +288 +00:19:33,590 --> 00:19:36,430 +الـ thrombus اللي اتكونت ما اتحللت فبالتالي برضه + +289 +00:19:36,430 --> 00:19:40,170 +هذا الشخص بيكون عرضة لإنه يصير عنده جلطات in + +290 +00:19:40,170 --> 00:19:44,370 +contrast على النقيض حالات الـ bleeding بتصير من إيش + +291 +00:19:44,370 --> 00:19:48,870 +حالات الـ bleeding بتصير لو صار defect في الـ + +292 +00:19:48,870 --> 00:19:51,370 +coagulation factor يعني في عندي مشكلة في الـ + +293 +00:19:51,370 --> 00:19:55,550 +coagulation factor في الـ process كلها بشكل عام أو + +294 +00:19:55,550 --> 00:20:00,050 +بسبب Accelerated Fibrinolysis يعني الـ fibrinolysis + +295 +00:20:00,050 --> 00:20:03,170 +كانت سريعة جداً فبالتالي مجرد ما اتكون الـ fibrin + +296 +00:20:03,170 --> 00:20:06,150 +ما لحقش يقوم بالوظيفة تبعته كان يصير له lysis + +297 +00:20:06,150 --> 00:20:10,250 +فبالتالي هذه الحالة أو هذه هتعمل عندنا طبعاً + +298 +00:20:10,250 --> 00:20:13,150 +coagulation cascade هنا بقول لك سواء intrinsic أو + +299 +00:20:13,150 --> 00:20:19,330 +extrinsic pathway هينشطولي الـ common pathway نيجي + +300 +00:20:19,330 --> 00:20:23,350 +للـ intrinsic pathway الـ intrinsic pathway زي ما + +301 +00:20:23,350 --> 00:20:27,410 +حكينا هو بيبدأ بالـ Activation لـ Factor 12 عن طريق + +302 +00:20:27,410 --> 00:20:30,930 +الـ Contact Factors الـ Contact Factors قد تكون + +303 +00:20:30,930 --> 00:20:33,730 +Negative لتشارج Phospholipid Surfaces زي الموجودة + +304 +00:20:33,730 --> 00:20:36,990 +في الـ Subendothelial tissue اللي بتظهر في حالة + +305 +00:20:36,990 --> 00:20:41,150 +حدوث جروح في خارج الجسم ممكن تكون Glass أو Kaolin + +306 +00:20:41,150 --> 00:20:45,270 +أو أشياء ثانية بتعطيني Negative Charge الـ Factors + +307 +00:20:45,270 --> 00:20:50,140 +اللي بتتم تقييمها في هذا الـ Pathway فاكتور 12، + +308 +00:20:50,140 --> 00:20:54,000 +فاكتور 11، فاكتور 9، فاكتور 8، prekallikrein، high + +309 +00:20:54,000 --> 00:20:58,340 +molecular weight منقص الـ activity للـ intrinsic + +310 +00:20:58,340 --> 00:21:04,180 +هو الـ pathway عن طريق الـ PTT هلقيت خليني أشوف + +311 +00:21:04,180 --> 00:21:09,380 +كيف الـ PTT نيجي للـ PTT قبل ما نحكي عن الـ PTT + +312 +00:21:09,380 --> 00:21:12,900 +بدنا نتذكر مع بعض العينة اللي كنا نسحبها كيف كنا + +313 +00:21:12,900 --> 00:21:16,920 +نسحبها وكيف كنا نتعامل معها بشكل سريع في فحوصات + +314 +00:21:16,920 --> 00:21:20,080 +الـ Hemostasis كنا نسحب عينة الدم في Sodium + +315 +00:21:20,080 --> 00:21:23,760 +Citrate كنا نستخدم الـ Anticoagulant اللي هو + +316 +00:21:23,760 --> 00:21:26,460 +Sodium Citrate Sodium Citrate هيعمل Capture + +317 +00:21:26,460 --> 00:21:30,480 +للكالسيوم فبالتالي هيمنع عملية الـ Coagulation + +318 +00:21:30,480 --> 00:21:35,240 +هلقيت العينة برضه إيش كنا نعمل فيها؟ كنا نعملها + +319 +00:21:35,240 --> 00:21:38,800 +centrifuge وقت طويل ونفصلها مرتين عسى إنه نتخلص + +320 +00:21:38,800 --> 00:21:42,600 +من الـ Platelet اللي فيها كنا نحصل على Platelet + +321 +00:21:42,600 --> 00:21:47,310 +Poor Plasma بمعنى إن عينة الـ Plasma اللي عندي لا + +322 +00:21:47,310 --> 00:21:51,550 +تحتوي على كالسيوم ولا تحتوي على Platelet Phospholipid + +323 +00:21:51,550 --> 00:21:55,290 +واتنين عاملين مهمين جداً في عملية الـ Coagulation + +324 +00:21:55,290 --> 00:21:58,150 +عشان هيك لو أنا بدي أعمل initiation للـ + +325 +00:21:58,150 --> 00:22:01,650 +Coagulation لازم أضيف الكالسيوم ولازم أضيف + +326 +00:22:01,650 --> 00:22:04,950 +الـ Phospholipid فبالتالي أنا عشان أضمن أن الـ + +327 +00:22:04,950 --> 00:22:09,130 +Intrinsic pathway هو اللي بدي يبدأ عندي بشغل + +328 +00:22:09,130 --> 00:22:14,170 +التفاعل كالتالي بضيف عليه Contact activator + +329 +00:22:14,170 --> 00:22:18,870 +و Phospholipid تمام بعد هيك بضيف الـ Calcium الـ + +330 +00:22:18,870 --> 00:22:21,850 +Calcium يعتبر كـ initiator اللي هو اللي بدي أبدأ + +331 +00:22:21,850 --> 00:22:24,730 +عندي الـ reaction لما بضيف الـ Calcium ببدأ أحسب أو + +332 +00:22:24,730 --> 00:22:29,210 +بشغل Stopwatch وببدأ أحسب قداش الوقت اللازم لتكون + +333 +00:22:29,210 --> 00:22:33,890 +الـ Fibrin in equilibrium طبعاً هذا الفحص لأنه احنا + +334 +00:22:33,890 --> 00:22:37,650 +شغلنا الـ intrinsic pathway هيشيك على أي خلل في الـ + +335 +00:22:37,650 --> 00:22:42,440 +intrinsic and common pathway هندى ملاحظة هنا إنه في + +336 +00:22:42,440 --> 00:22:44,620 +عندي بعض الـ Drugs زي الـ Heparin والـ + +337 +00:22:44,620 --> 00:22:47,620 +Warfarin في عندي الـ Factor Inhibitor اللي هو بس + +338 +00:22:47,620 --> 00:22:53,120 +Anticoagulant عادة بتعمل prolongation للـ PTT طيب + +339 +00:22:53,120 --> 00:22:56,440 +نيجي للـ Extrinsic Pathway اللي هو الـ Tissue + +340 +00:22:56,440 --> 00:23:00,880 +Factor Pathway عادة هذا لما بيصير جروح بيطلع الـ + +341 +00:23:00,880 --> 00:23:06,360 +Tissue Factor الـ Tissue Factor هيعمل activation + +342 +00:23:06,360 --> 00:23:08,980 +لـ Factor 7 هيرتبط مع Factor 7 الـ Active + +343 +00:23:09,300 --> 00:23:12,720 +وبالتالي يعمل activation لـ Factor 10 ويبدأ عندي + +344 +00:23:12,720 --> 00:23:16,720 +بعدها الـ Common Pathway بتم تقييم الـ Extrinsic + +345 +00:23:16,720 --> 00:23:23,580 +Pathway عن طريق فحص الـ PT فحص + +346 +00:23:23,580 --> 00:23:28,520 +الـ PT أنا بدي أشغل فيه الـ Extrinsic Pathway مش + +347 +00:23:28,520 --> 00:23:32,820 +الـ Intrinsic Pathway فبجيب مادة زي الـ Tissue + +348 +00:23:32,820 --> 00:23:36,620 +Factor اللي هي طبعاً هي Tissue Factor لكن ممكن يكون + +349 +00:23:36,620 --> 00:23:40,120 +لها أكثر من مصدر مش شرط تكون من الـ Human يعني وإن + +350 +00:23:40,120 --> 00:23:44,220 +كان الأفضل اللي هو الـ Human Tissue Factor بجيب + +351 +00:23:44,220 --> 00:23:46,900 +الـ Thromboplastin اللي هو الـ Tissue Factor بضيفه + +352 +00:23:46,900 --> 00:23:49,840 +على العينة مع الـ Calcium فهيبدأ الـ Pathway هنا + +353 +00:23:49,840 --> 00:23:53,120 +هيبدأ الـ Extrinsic Pathway ليش؟ لأني أنا حطيت له الـ + +354 +00:23:53,120 --> 00:23:58,060 +Tissue Factor طبعاً بعمل initiation وبشوف الوقت + +355 +00:23:58,060 --> 00:24:03,720 +اللازم لتكون هنا هيشيك عندي على الـ Extrinsic + +356 +00:24:03,720 --> 00:24:08,820 +Factors والـ Common Pathway Factors اللي هو الـ PT + +357 +00:24:08,820 --> 00:24:12,400 +الـ + +358 +00:24:12,400 --> 00:24:15,340 +Common Pathway الـ Common Pathway هتشتغل فيه + +359 +00:24:15,340 --> 00:24:19,580 +فاكتور 5، فاكتور 10، فاكتور 13، فاكتور 2 زي ما + +360 +00:24:19,580 --> 00:24:22,800 +أنتم شايفين في عندي الـ Complex هيعمل + +361 +00:24:22,800 --> 00:24:26,600 +Activation هذا جاي من الـ Intrinsic Pathway هيعمل + +362 +00:24:26,600 --> 00:24:31,050 +Activation لـ فاكتور عشرة وبعدين بيجي الـ Prothrombinase + +363 +00:24:31,050 --> 00:24:34,550 +Complex وبيكمل عندي لغاية ما يتكون عندي الـ + +364 +00:24:34,550 --> 00:24:38,590 +Fibrin Polymer أتوقع إن الـ PT أو الـ PTT بكشف + +365 +00:24:38,590 --> 00:24:41,710 +عندي إذا كان فيه خلل في الـ Common Pathway وعادة + +366 +00:24:41,710 --> 00:24:44,330 +إذا كان فيه خلل في الـ Factors بتاعة الـ Common + +367 +00:24:44,330 --> 00:24:52,190 +Pathway هيتأثر الإثنين هيتأثر عندي الـ PT والـ + +368 +00:24:52,190 --> 00:24:52,470 +PTT + +369 +00:24:55,680 --> 00:24:59,040 +طبعاً هندى هذا الـ Cascade ملخص بيوضح فيه الـ + +370 +00:24:59,040 --> 00:25:01,720 +Intrinsic والـ Extrinsic pathway والـ Common + +371 +00:25:01,720 --> 00:25:08,340 +pathway طيب هلقات احنا حكينا عن الـ Coagulation + +372 +00:25:08,340 --> 00:25:12,840 +cascade زي ما في عندي Coagulation cascade في عندي + +373 +00:25:12,840 --> 00:25:16,520 +Anti-coagulant pathway هلقات عملية الـ Coagulation + +374 +00:25:16,520 --> 00:25:21,820 +مش لازم تضل شغالة على طول لازم تيجي أشياء توقف + +375 +00:25:21,820 --> 00:25:25,190 +عملية الـ Coagulation ففي عندي أكثر من pathway في + +376 +00:25:25,190 --> 00:25:30,490 +عندي الـ antithrombin pathway في عندي protein C + +377 +00:25:30,490 --> 00:25:33,250 +-thrombomodulin pathway في عندي tissue factor + +378 +00:25:33,250 --> 00:25:37,090 +مثلما أنتم شايفين في عندي أكثر من anticoagulant + +379 +00:25:37,090 --> 00:25:41,850 +pathway في عندي ال tissue factor pathway inhibitor + +380 +00:25:41,850 --> 00:25:45,050 +في عندي ال antithrombin 3 + +381 +00:25:47,610 --> 00:25:51,650 +طيب نجي لأول pathway اللي هي في الـ Anti + +382 +00:25:51,650 --> 00:25:54,410 +-coagulation اللي هي الـ Anti-thrombin pathway + +383 +00:25:54,410 --> 00:25:59,090 +Anti-thrombin يعتبر أهم inhibitor لـ coagulation + +384 +00:25:59,090 --> 00:26:05,130 +للثرمبين بيشكل حوالي 80% of thrombin inhibitory + +385 +00:26:05,130 --> 00:26:10,190 +activity in plasma يعني هو أهم pathway عندنا الـ + +386 +00:26:10,190 --> 00:26:13,790 +Anti-thrombin عادة بيعمل inhibition directly + +387 +00:26:14,470 --> 00:26:18,810 +للثرمبين ولفاكتور عشرة بالإضافة ل factor X active + +388 +00:26:18,810 --> 00:26:22,490 +طبعا هو لما يعمل inhibition للثرمبين ولفاكتور عشرة + +389 +00:26:22,490 --> 00:26:25,750 +أكيد هيتوقف ال pathway لأن هذه ال factors المفروضة + +390 +00:26:25,750 --> 00:26:30,010 +تقوم بدورها لكن هو طالما عمللها block مش هيتكمل ال + +391 +00:26:30,010 --> 00:26:33,230 +pathway وبالتالي مش هيتكون الفيبرين وهكذا هو يقوم + +392 +00:26:33,230 --> 00:26:39,650 +بدوره ك anticoagulant طيب نشوف تفاصيل أكثر عن + +393 +00:26:39,650 --> 00:26:45,550 +الموضوع ال antithrombin بعمل inhibition زي ما قلنا + +394 +00:26:45,550 --> 00:26:49,950 +بشكل مباشر أو بشكل أساسي للثرمبين و ل factor 10 + +395 +00:26:49,950 --> 00:26:52,830 +active بالإضافة لأنه بعمل inhibition ل other + +396 +00:26:52,830 --> 00:26:58,050 +factors زي factor 9 active، factor 11، factor 12 + +397 +00:26:58,050 --> 00:27:03,430 +active بعمل inhibition لل complement enzyme C1 كيف + +398 +00:27:03,430 --> 00:27:07,530 +بتصير عملية ال inhibition لما بيصير جروح بتطلع + +399 +00:27:07,530 --> 00:27:11,150 +مادة الهيبارانسلفات هذه المادة بتطلع من ال + +400 +00:27:11,150 --> 00:27:15,970 +endothelial cells مادة شبيهة بالـ Heparin هذه + +401 +00:27:15,970 --> 00:27:22,210 +المادة راح تروح و هي مرتبطة بالـ Antithrombin لما + +402 +00:27:22,210 --> 00:27:26,950 +بترتبط فيه بتعمل له conformational changes بتغير + +403 +00:27:26,950 --> 00:27:31,970 +الشكل أو التركيبة بتاعته بحيث أنه يصير سهل عليه + +404 +00:27:31,970 --> 00:27:36,550 +أنه يرتبط بالإنزيم أو بالإنزايم و يعمله + +405 +00:27:36,550 --> 00:27:40,880 +inactivation This facilitated its reaction with the + +406 +00:27:40,880 --> 00:27:43,560 +enzyme أنتثرومبين form a complex with the + +407 +00:27:43,560 --> 00:27:47,200 +inhibited proteins بعد هي ارتبط مع الانزيم اللي + +408 +00:27:47,200 --> 00:27:52,560 +صارله هنا هذه ميكانيزم بسيطة ورسم تخطيتي بسيط جدا + +409 +00:27:52,560 --> 00:27:57,320 +بيوضح عندي كيف ارتباط الانتثرومبين مع الهيبرين أو + +410 +00:27:57,320 --> 00:28:01,000 +مع الهيبرانسالفات بيغير ال confirmation لإله بيصير + +411 +00:28:01,000 --> 00:28:04,940 +موائم لارتباط بال active factors خلّيني أشوف هلأ + +412 +00:28:04,940 --> 00:28:10,680 +هاي عندنا الهيبرين في عندي الـ Antithrombin ارتباط + +413 +00:28:10,680 --> 00:28:13,920 +الهيبرين مع الـ Antithrombin هيغير شكل الـ + +414 +00:28:13,920 --> 00:28:19,040 +Antithrombin شفتين كيف صار شكله؟ فهذا الشكل هيصير + +415 +00:28:19,040 --> 00:28:23,640 +موائم لشكل factor 10 active و factor 2 active اللي + +416 +00:28:23,640 --> 00:28:26,860 +هو الـ Thrombin وبالتالي هيصير ارتباط بينهم و + +417 +00:28:26,860 --> 00:28:30,640 +هيصير هذا ال factor اللي كان active هيصير inactive + +418 +00:28:32,100 --> 00:28:35,440 +الرسمة اللي معكم هيها الرسمة اللي معكم في الملزمة + +419 +00:28:35,440 --> 00:28:39,100 +خلينا نشوف إيش فيها في عندي الـ Antithrombine + +420 +00:28:39,100 --> 00:28:41,920 +والهيبرين لما يرتبط الـ Antithrombine بالهيبرين + +421 +00:28:41,920 --> 00:28:46,920 +بصير موائم لارتباط للثرمبين بعد هيك بنفك الهيبرين + +422 +00:28:46,920 --> 00:28:53,560 +فبالتالي هيتكون عندي Complex من ال factor اللي صار + +423 +00:28:53,560 --> 00:28:59,310 +inactive مع الـ Antithrombine وهيك بنكون نجي للـ + +424 +00:28:59,310 --> 00:29:03,030 +pathway الثاني اللي هو protein C pathway خلّوا + +425 +00:29:03,030 --> 00:29:06,530 +بالكم إحنا بنحكي عن anticoagulant pathway يعني + +426 +00:29:06,530 --> 00:29:10,810 +هيمشي الكسكيت ويكون عندي الـ coagulation factors + +427 +00:29:10,810 --> 00:29:14,770 +الـ active وحتى تبدأ تتكون الفيبرين هلأ في مرحلة + +428 +00:29:14,770 --> 00:29:17,910 +معينة لازم الكسكيت هذا يبدأ يشتغل له الـ + +429 +00:29:17,910 --> 00:29:22,390 +anticoagulant عشان يوقف الـ coagulation أو يقلل من + +430 +00:29:22,390 --> 00:29:26,670 +الـ coagulation إيش اللي بصير؟ لما بزيد في ثرمبين + +431 +00:29:27,500 --> 00:29:31,220 +نتيجة الـ activation لـ Coagulation cascade + +432 +00:29:31,220 --> 00:29:35,720 +الثرمبين هذا هيروح يرتبط مع الـ Thrombomodulin + +433 +00:29:35,720 --> 00:29:41,240 +ثرمبوموديولين هذا موجود على الـ Endothelium هيكون + +434 +00:29:41,240 --> 00:29:46,980 +ثرمبين ثرمبوموديولين Complex هذا الـ Complex هيعمل + +435 +00:29:46,980 --> 00:29:52,820 +activation لبروتين C البروتين C هيصير Active + +436 +00:29:52,820 --> 00:29:57,390 +بروتين C فلقيت لما بيصير activation لبروتين C هيروح + +437 +00:29:57,390 --> 00:30:00,190 +الـ «بروتين C» يرتبط مع «cofactor» اللي هو «بروتين + +438 +00:30:00,190 --> 00:30:05,150 +S» ومع «factor V» inactive فلقيت ال «complex» اللي + +439 +00:30:05,150 --> 00:30:08,590 +اتوان عندي أكثر «بروتين C» و«بروتين S» و«factor V» + +440 +00:30:08,590 --> 00:30:11,910 +inactive هيعملوا «inactivation» لـ «factor VIII» + +441 +00:30:11,910 --> 00:30:17,570 +و«inactivation» لـ «factor V» وهيك هيوقفوا تكون + +442 +00:30:17,570 --> 00:30:22,660 +الـ «Thrombin» تمام؟ لأنه زي ما أنتم عارفين فاكتور + +443 +00:30:22,660 --> 00:30:27,760 +5 هو جزء أساسي في الـ Thrombinase Complex و فاكتور + +444 +00:30:27,760 --> 00:30:31,360 +8 جزء أساسي في التمنازل Complex فطالما صار ان + +445 +00:30:31,360 --> 00:30:36,280 +اكتشف هذه زي ما أنتم شايفين الاثرومبين اتكون + +446 +00:30:36,280 --> 00:30:41,700 +نتيجة طبعا بدت تتكون ال clot ومش الكسكاد وزاد + +447 +00:30:41,700 --> 00:30:45,380 +الاثرومبين في ال blood زيادة الاثرومبين حيرضت مع + +448 +00:30:45,380 --> 00:30:49,400 +الاثرومبوموديولينهيعمل أثرومبين أثرومبوموديولين + +449 +00:30:49,400 --> 00:30:53,440 +Complex هدول إيش راح يعملوا؟ راح يعملوا activation + +450 +00:30:53,440 --> 00:31:01,260 +لبروتين C هيتكون عندي active بروتين C طبعا اتكونت + +451 +00:31:01,260 --> 00:31:04,880 +الأثرومبس عليها factor 5 active و عليها factor 8 + +452 +00:31:04,880 --> 00:31:13,640 +active هيجي بروتين C ال active طبعا بمساعدة بروتين + +453 +00:31:13,640 --> 00:31:19,820 +S هيعملوا الـ Factor 8 Active هيتحول لـ Factor 8 + +454 +00:31:19,820 --> 00:31:26,780 +Inactive برضه هنا هيصير عندي بمساعدة Factor 5 + +455 +00:31:26,780 --> 00:31:29,860 +هيصير Inactivation لـ Factor 5 فبالتالي هيتوقف + +456 +00:31:29,860 --> 00:31:33,320 +Factor 5 و Factor 8 الـ Active هيصير لهم + +457 +00:31:33,320 --> 00:31:37,680 +Inactivation و هيتوقف الـ Cascade هنا بيحكي لنا + +458 +00:31:37,680 --> 00:31:42,890 +أنه فين أشياء بتعتبر كـ Co-factors لـ Protein S لـ + +459 +00:31:42,890 --> 00:31:46,550 +Protein C عفواً اللي هي Protein S و Factor 5 الـ + +460 +00:31:46,550 --> 00:31:49,690 +Protein S بيساعد الـ Active Protein C على إنه + +461 +00:31:49,690 --> 00:31:52,190 +يرتبط مع الـ Phospholipids بتاعة الـ Platelets و + +462 +00:31:52,190 --> 00:31:55,810 +الـ Endothelium الـ Protein S اللي بيشتغل لازم + +463 +00:31:55,810 --> 00:32:00,790 +يكون Free لكن قريب من 60% من الـ Protein S بنلاقي + +464 +00:32:00,790 --> 00:32:07,430 +مرتبط بـ C4B Binding Protein Factor 5 مع Protein S + +465 +00:32:07,430 --> 00:32:12,870 +طبعاً زي ما قلنا بيخلوا الـ Active Protein C يعمل + +466 +00:32:12,870 --> 00:32:18,410 +degradation لـ factor 8 و factor 9 نيجي للميكانيزم + +467 +00:32:18,410 --> 00:32:23,970 +الثالث اللي هو tissue factor pathway inhibitor هذا + +468 +00:32:23,970 --> 00:32:27,750 +بيطلع من الـ endothelium لما بيصير activation لل + +469 +00:32:27,750 --> 00:32:32,450 +pathway لل factors برتبط مع factor 10 active + +470 +00:32:32,450 --> 00:32:36,990 +بيعملوا complex factor 10 active مع Tissue Factor + +471 +00:32:36,990 --> 00:32:40,850 +Pathway Inhibitor ويروح ويرتبطه بتعوني الـ + +472 +00:32:40,850 --> 00:32:44,430 +Extrinsic Pathway الـ Tissue Factor مع Factor 7 + +473 +00:32:44,430 --> 00:32:48,350 +Active وبالتالي بعمل Inactivation للـ Extrinsic + +474 +00:32:48,350 --> 00:32:53,370 +Pathway طيب + +475 +00:32:53,370 --> 00:32:57,830 +نيجي للـ Fibrinolytic Pathway طبعا إحنا بمجرد ما + +476 +00:32:57,830 --> 00:33:01,630 +الفيبرين يتكون هتبدأ عملية الـ Fibrinolysis لأن هو + +477 +00:33:01,630 --> 00:33:04,670 +بده يقدي وظيفة وينتهي مش لازم يظل موجود في الجسم + +478 +00:33:05,630 --> 00:33:11,530 +طبعاً في عندي بلازمينوجين البلازمينوجين هذا هو + +479 +00:33:11,530 --> 00:33:15,310 +اللي بتتحول لبلازمين وبيعمل على تكسير الـ fibrin + +480 +00:33:15,310 --> 00:33:19,690 +اللي اتكون البلازمينوجين بده يصير له activation إما + +481 +00:33:19,690 --> 00:33:22,610 +بيصير له in vivo عن طريق tissue plasminogen + +482 +00:33:22,610 --> 00:33:27,330 +activator هذا بيجي من الـ Indothelium أو عن طريق + +483 +00:33:27,330 --> 00:33:32,690 +اليوركيناز plasminogen activator ممكن يكون اكسوجنس + +484 +00:33:32,880 --> 00:33:36,080 +عن طريق الـ streptokinase اللي بينعطل المرضى اللي + +485 +00:33:36,080 --> 00:33:41,940 +عندهم جلطات عشان يتدوب الجلطات كلهم بيشتغل على الـ + +486 +00:33:41,940 --> 00:33:44,540 +plasminogen بيعملوا activation بيحولوا إلى + +487 +00:33:44,540 --> 00:33:49,960 +البلازمين البلازمين هذا هيعمل degradation للفيبرين + +488 +00:33:49,960 --> 00:33:54,280 +وعلى الفيبرينوجين لو شغل على الفيبرينوجين هيعطيني + +489 +00:33:54,280 --> 00:33:57,740 +D-dimer لكن لو شغل على الفيبرينوجين مش هيعطي D + +490 +00:33:57,740 --> 00:34:01,480 +-dimer علشان هيك الـD-dimer ارتفاع ودليل على انه + +491 +00:34:01,480 --> 00:34:06,720 +فيه هطلعوا معايا Degradation of fibrin and + +492 +00:34:06,720 --> 00:34:09,700 +fibrinogen «فيبرين» or «فيبرين» «فيبرينوجين» or + +493 +00:34:09,700 --> 00:34:10,780 +«فيبرين» «فيبرين» or «فيبرين» «فيبرينوجين» or + +494 +00:34:10,780 --> 00:34:14,280 +«فيبرين» «فيبرينوجين» or «فيبرين» «فيبرينوجين» + +495 +00:34:14,280 --> 00:34:14,980 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +496 +00:34:14,980 --> 00:34:15,040 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +497 +00:34:15,040 --> 00:34:15,820 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +498 +00:34:15,820 --> 00:34:18,080 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +499 +00:34:18,080 --> 00:34:25,460 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» «فيبرينوج + +500 +00:34:31,020 --> 00:34:33,780 +لغاية ما في النهاية يصير complete degradation + +501 +00:34:33,780 --> 00:34:38,980 +لإلهم الآن كيف بدنا نعمل evaluation للـFibrinolysis + +502 +00:34:38,980 --> 00:34:44,300 +إذا كان فعلا صار فيه اتكوّن fibrin clot وصار لها + +503 +00:34:44,300 --> 00:34:48,700 +degradation هنلاقي الـD-dimer ارتفع في blood إذا + +504 +00:34:48,700 --> 00:34:51,160 +وجود الـD-dimer قد يعطي + +505 +00:35:00,380 --> 00:35:04,640 +في حالات الـ Pulmonary embolism الـ DIC و الـ Normal + +506 +00:35:04,640 --> 00:35:07,160 +الـ Pregnancy ولو صار فيه Complication في الـ + +507 +00:35:07,160 --> 00:35:10,280 +pregnancy هتلاقي ال level تاعه ارتفع بشكل كبير و +508 +00:35:10,280 --> 00:35:10,780 +ملحوظ diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..3c7d4610e8c0b360bd6b587c6080e81f14ceed8b --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_postprocess.srt @@ -0,0 +1,2032 @@ +1 +00:00:00,880 --> 00:00:04,800 +بسم الله الرحمن الرحيم محاضرتنا ان شاء الله راح + +2 +00:00:04,800 --> 00:00:08,400 +تكون Introduction to Special Hemostasis أو + +3 +00:00:08,400 --> 00:00:12,540 +Coagulation عملية + +4 +00:00:12,540 --> 00:00:18,180 +الـ Hemostasis عادة بتبدأ بحدوث جروح معين لما + +5 +00:00:18,180 --> 00:00:23,090 +بيحلث الجروح بتتكون لـ Clotالأن لما بتتكون لـ Clot + +6 +00:00:23,090 --> 00:00:26,370 +أكيد راح يصير الشغل اللي بعدها Clot Dissolution + +7 +00:00:26,370 --> 00:00:29,690 +لأن الـ Clot دي مش لازم تظل موجودة في مكانها لازم + +8 +00:00:29,690 --> 00:00:32,670 +يصير لها تحليل وإلا بيصير الـ Thrombosis بيصير + +9 +00:00:32,670 --> 00:00:37,870 +تجلطات عشان هيك تعتبر عملية الـ Hemostasis أنه + +10 +00:00:37,870 --> 00:00:41,490 +بيحدث فيها Balance ما بين Clot Formation and Clot + +11 +00:00:41,490 --> 00:00:46,110 +Dissolution موضوع الـ Hemostasis طبعاً بيساهم في + +12 +00:00:46,110 --> 00:00:51,600 +ثلاث أشياء مهمة ال Vasculature Coagulationنحكي + +13 +00:00:51,600 --> 00:00:55,040 +بداية عن الـ Blood vessels لما بنحكي عن الـ Blood + +14 +00:00:55,040 --> 00:00:58,800 +vessels أكتر شئ بهمني فيها اللي هو الـ Endothelium + +15 +00:00:58,800 --> 00:01:04,380 +المبطن لإلها الـ Endothelium هذا الصحيح هو يعني + +16 +00:01:04,380 --> 00:01:08,800 +يُعتبر Dynamic Organ إيش يعني Dynamic Organ إبارة + +17 +00:01:08,800 --> 00:01:15,540 +عن جزء أو Organ عملي كيف يعني عملي بيقدر يتأقلم + +18 +00:01:15,540 --> 00:01:20,890 +ويغير وظيفته حسبالبيئة المحيطة فيه يعني على سبيل + +19 +00:01:20,890 --> 00:01:24,670 +المثال في جروح هو بدي أقلم حاله إنه يسكر الجروح + +20 +00:01:24,670 --> 00:01:30,050 +فبصير يعطي أشياء تساعد على تسكير الجروح بصير يساعد + +21 +00:01:30,050 --> 00:01:33,330 +على تكوين الجلطة يساعد على البلاتلة aggregation و + +22 +00:01:33,330 --> 00:01:36,890 +adhesion بيساعد على إنه يصير vasoconstriction + +23 +00:01:36,890 --> 00:01:41,730 +بيعطي مواد تضيق لـ blood vessel الآن مافيش عندنا + +24 +00:01:41,730 --> 00:01:45,470 +جروح هو بطبيعته بيكون thromboresistant إيش يعني + +25 +00:01:45,470 --> 00:01:50,110 +thromboresistant؟الـ Endothelial نفسه يعني مانع + +26 +00:01:50,110 --> 00:01:53,710 +لتكوين الجلطات يمنع التصاق لـ Platelet فيه عمق + +27 +00:01:53,710 --> 00:01:56,010 +وإنه يصير Platelet adhesion and aggregation + +28 +00:01:56,010 --> 00:01:59,490 +بالإضافة لإنه بيمنع عملية الـ Thrombosis فبالتالي + +29 +00:01:59,490 --> 00:02:03,770 +هو حسب البيئة المحيطة فيه هيشتغل حسب الظرف اللي هو + +30 +00:02:03,770 --> 00:02:07,430 +فيه هيغير وظيفته و هيفرز مواد مختلفة يعني هنلاقي + +31 +00:02:07,430 --> 00:02:11,530 +إنه بيفرز أشياء ممكن تعمل كـ Stimulators و أشياء + +32 +00:02:11,530 --> 00:02:15,200 +هتعمل Inhibitorsفي حاجات هتعمل Vasoconstriction + +33 +00:02:15,200 --> 00:02:20,240 +وفي حاجات هتعمل Vasodilation وظائف الـ Vascular + +34 +00:02:20,240 --> 00:02:24,300 +Endothelium أو بعض الأشياء اللي بيفرزها ونشوف إيش + +35 +00:02:24,300 --> 00:02:27,600 +وظيفتها زي أن مثلا الـ Prostacycline الـ + +36 +00:02:27,600 --> 00:02:30,080 +Prostacycline هذا بيعمل في الوضع الطبيعي + +37 +00:02:30,080 --> 00:02:32,560 +Vasodilation لأنه أنا بدي ال blood vessel في الوضع + +38 +00:02:32,560 --> 00:02:36,100 +الطبيعي بدون جروح يبقى متسع و ال blood يمشي + +39 +00:02:36,100 --> 00:02:39,840 +بأرياحيةشغلة تانية Inhibition of platelet + +40 +00:02:39,840 --> 00:02:42,700 +aggregation وهذا اللي أنا بدياه بالوضع الطبيعي أنا + +41 +00:02:42,700 --> 00:02:45,840 +مابدي يصير platelet aggregation الـ Thrombocytin + +42 +00:02:45,840 --> 00:02:49,280 +A2 هذا بتكون لـ platelets بعمل construction لـ + +43 +00:02:49,280 --> 00:02:54,660 +blood vessels أو لـ muscular arteries في عندي + +44 +00:02:54,660 --> 00:02:58,900 +شغلات أخرى زي الـ ELAMs and ICAMs هذه عبارة عن + +45 +00:02:58,900 --> 00:03:05,260 +cytokines بيفرزها الـ endotheliumالـ cytokines هذه + +46 +00:03:05,260 --> 00:03:09,500 +إلها علاقة في جذب الـ white bcs إلى مكان ال + +47 +00:03:09,500 --> 00:03:13,080 +inflammation والتصاقها فيه فبالتالي هو إيه وإيه + +48 +00:03:13,080 --> 00:03:16,420 +علاقة بال inflammatory process الـ von و ال brand + +49 +00:03:16,420 --> 00:03:20,520 +factor طبعا مهم جدا في التصاق لـ platelets مع ال + +50 +00:03:20,520 --> 00:03:26,190 +subendothelial collagenالشغلات تانية ممكن يعطيها + +51 +00:03:26,190 --> 00:03:32,990 +زي الـ Tissue Factor Pathway Inhibitors في عندى زى + +52 +00:03:32,990 --> 00:03:36,530 +ما أنتوا عارفين لما بتكون الـ Fibrin فالنهاية أنا + +53 +00:03:36,530 --> 00:03:39,130 +بدى أوقف عملية الـ Coagulation خلاص مابديها تظل + +54 +00:03:39,130 --> 00:03:42,390 +مستمرة للأبد لازم توقف قد وظيفته وتكون الـ Fibrin + +55 +00:03:42,390 --> 00:03:46,240 +لازم توقف العملية هذهفبالتالي بتطلع عندي مواد + +56 +00:03:46,240 --> 00:03:49,300 +بتعمل كـ Anticoagulant من الـ Anticoagulants هذه و + +57 +00:03:49,300 --> 00:03:52,120 +اللي بيساهم الـ Endothelium في تكوينها اللي هو الـ + +58 +00:03:52,120 --> 00:03:56,560 +Tesiofactor Pathway Inhibitor هذا بيوقف الـ + +59 +00:03:56,560 --> 00:03:59,420 +Coagulation عن طريق توقيف الـ Extrinsic Pathway + +60 +00:03:59,420 --> 00:04:03,200 +راح نشوف لقدام كيف فيه أن الـ Thrombomodulin، + +61 +00:04:03,200 --> 00:04:05,780 +Thrombomodulin هذا بيعمل Inhibition للـ + +62 +00:04:05,780 --> 00:04:08,780 +Coagulation عن طريق الـ Activation للـ Protein C + +63 +00:04:08,780 --> 00:04:13,130 +System اللي بدوره بيوقف الـ Coagulationفي عند الـ + +64 +00:04:13,130 --> 00:04:16,530 +Tissue Plasminogen Activator طبعاً الـ Plasminogen + +65 +00:04:16,530 --> 00:04:21,670 +هذا بيبدأ عملية الـ Fibrinolysis فبالتالي هو بيشجع + +66 +00:04:21,670 --> 00:04:25,050 +الـ Fibrinolysis في أن الهيبرينسالفات + +67 +00:04:25,050 --> 00:04:28,370 +البروتيوجلاكان برضه من الأشياء اللي بيفرزها هذا + +68 +00:04:28,370 --> 00:04:33,350 +بيعمل Inhibition لل-coagulation by activation of + +69 +00:04:33,350 --> 00:04:36,730 +antithrombine يعني بنشط الـ antithrombine فبالتالي + +70 +00:04:36,730 --> 00:04:40,420 +بيعمل كـ Anticoagulantبالإضافة لأنه بيعطينا الـ + +71 +00:04:40,420 --> 00:04:43,120 +tissue factor الـ tissue factor بيرتبط إلى factor + +72 +00:04:43,120 --> 00:04:49,260 +7 وبيعمل initiation للextrinsic pathway يعني هنا + +73 +00:04:49,260 --> 00:04:55,120 +كـ anticoagulant شغال و كprocoagulant نيجي للـ + +74 +00:04:55,120 --> 00:04:58,380 +blood platelets البلاتلتز زي ما احنا عارفين هي + +75 +00:04:58,380 --> 00:05:02,280 +بتتكون من الـ cytoplasm للبوم مارو ميجا كاريوسايت + +76 +00:05:02,280 --> 00:05:06,080 +طبعا هي أصغر واحدة في ال blood cells أو ال + +77 +00:05:06,080 --> 00:05:09,500 +component elements بتاعة ال bloodالوضع الطبيعي لها + +78 +00:05:09,500 --> 00:05:15,060 +عددها يتروح ما بين 150 إلى 450 ألف شكلها disk + +79 +00:05:15,060 --> 00:05:19,320 +shape a enucleated cell with complex internal + +80 +00:05:19,320 --> 00:05:23,440 +structure يعني في تركيبها الداخل المعقد يعكس ما + +81 +00:05:23,440 --> 00:05:26,020 +تقوم به من وظيفة في الهيموستاسس + +82 +00:05:29,330 --> 00:05:33,910 +طيب لـ Platelets أهم حاجة في تركيبها اللي هي الـ + +83 +00:05:33,910 --> 00:05:36,450 +Granules اللي موجودة فيها اللي بتقوم بالوظائف + +84 +00:05:36,450 --> 00:05:38,670 +المهمة في الـ Hemostasis في عندنا الـ Alpha + +85 +00:05:38,670 --> 00:05:42,530 +Granules وفي عندنا الـ Densy Granules الـ Alpha + +86 +00:05:42,530 --> 00:05:46,350 +Granules إيش محتوياتها؟ هيكون فيها بعض الـ + +87 +00:05:46,350 --> 00:05:49,630 +Coagulation Factors زي الـ Fibrinogen، Vinyl Brand + +88 +00:05:49,630 --> 00:05:53,990 +Factor فيها الـ Coagulation Factor خمسة و تمانية + +89 +00:05:53,990 --> 00:05:58,460 +فيها كمان Platelet Derived Growth Factorفي عند الـ + +90 +00:05:58,460 --> 00:06:03,120 +Densy Granules الـ Densy Granules صميت هيك لأن هيك + +91 +00:06:03,120 --> 00:06:06,180 +بتظهر في الـ electron microscope هذه بتحتوي على + +92 +00:06:06,180 --> 00:06:09,620 +الـ ATP وبتحتوي على الـ ADP وبتحتوي على + +93 +00:06:09,620 --> 00:06:13,900 +السيروتونين الـ Granules هذه بيصيرلها release في + +94 +00:06:13,900 --> 00:06:19,140 +حالة البلاتلت activation هنا + +95 +00:06:19,140 --> 00:06:22,620 +عندنا صورة بتوضح أهم إشي يعني بتوضح تركيبة + +96 +00:06:22,620 --> 00:06:26,520 +البلاتلت أهم إشي بيهمني اللي هي ال .. ال .. ال .. + +97 +00:06:26,520 --> 00:06:30,520 +ال ..اللي هي الـ Density Granules والـ Alpha-A + +98 +00:06:30,520 --> 00:06:33,920 +Granules هيهم وهي محتوياتهم واضحين عندنا بالصورة + +99 +00:06:33,920 --> 00:06:36,940 +طيب، + +100 +00:06:36,940 --> 00:06:42,480 +نشوف الآن كيف بيصير الـ Platelet Activate خلينا + +101 +00:06:42,480 --> 00:06:46,740 +نتخيل blood vessel وعاء دموي الوعاء الدموي هذا + +102 +00:06:46,740 --> 00:06:49,960 +عادة بيكون مبطن بالـ Endothelial اللي هو الخط + +103 +00:06:49,960 --> 00:06:54,780 +الأحمر فيه تحت منه الـ Subendothelial اللي هو الخط + +104 +00:06:54,780 --> 00:06:59,220 +المتقطع الأبيض اللي باينهلقيت في الوضع الطبيعي هي + +105 +00:06:59,220 --> 00:07:01,780 +البلاد اللي تماشية في الـ blood vessel في عندي + +106 +00:07:01,780 --> 00:07:07,560 +coagulation factors في عندي يعني integral + +107 +00:07:07,560 --> 00:07:11,840 +integrated اندوثيليام شايفين كيف الاندوثيليام هنا + +108 +00:07:11,840 --> 00:07:15,340 +متكامل هلقيت صار جروح تخيلوا على الجهة التانية صار + +109 +00:07:15,340 --> 00:07:19,520 +عندي جروح الجروح هذا هيعمل exposing للـsub + +110 +00:07:19,520 --> 00:07:24,340 +endothelial الـsub endothelial هذا هيصير باين + +111 +00:07:24,340 --> 00:07:29,500 +وظاهرفبالتالي الآن هتبدأ عملية ارتباط لـ Platelets + +112 +00:07:29,500 --> 00:07:32,460 +بالـ Subendothelium عشان تعمل Platelet Adhesion + +113 +00:07:32,460 --> 00:07:35,720 +على الهامش، في عندي هنا Release للـ Tissue Factor + +114 +00:07:35,720 --> 00:07:38,440 +الـ Tissue Factor هنا مش هيلزمني في الـ Extrinsic + +115 +00:07:38,440 --> 00:07:43,520 +Pathway لكن هو بيقولك يعني إنه الـ Sub … برضه الـ + +116 +00:07:43,520 --> 00:07:47,820 +Endothelium بيساعد على الـ Release للـ Tissue + +117 +00:07:47,820 --> 00:07:51,560 +Factor اللي بيساعد في سيكندرية مستهزة، تمام؟ + +118 +00:07:51,560 --> 00:07:55,840 +خلّينا في موضوع إنه صار جروح، صار Injuryصار + +119 +00:07:55,840 --> 00:07:58,740 +Exposing للـ Subendothelial خلّيني نشوف إيش بيصير + +120 +00:07:58,740 --> 00:08:03,240 +هلقت + +121 +00:08:03,240 --> 00:08:07,060 +الجروح هيطلع عندي Von Willebrand Factor الـ Von + +122 +00:08:07,060 --> 00:08:10,340 +Willebrand Factor هذا راح يربط البلاتلت مع الـ + +123 +00:08:10,340 --> 00:08:14,860 +Subendothelial tissue كيف؟ عن طريق ريسبتر على صفح + +124 +00:08:14,860 --> 00:08:20,190 +البلاتلت اللي هو Glycoprotein 1Bهذا هو اللي بتم من + +125 +00:08:20,190 --> 00:08:23,950 +خلاله ارتباط البلاتلت مع الـ Von والـ Brand Factor + +126 +00:08:23,950 --> 00:08:28,550 +اللي بدوره بيمسك البلاتلت على الـ Subendothelial + +127 +00:08:28,550 --> 00:08:32,850 +tissue وهذه مرحلة الـ Initial Blatlet Activation + +128 +00:08:32,850 --> 00:08:36,550 +بحيث أنه يصير Adhesion للبلاتلت مع الـ + +129 +00:08:36,550 --> 00:08:39,490 +Subendothelium تمام؟ إذن هي المرحلة الأولى في + +130 +00:08:39,490 --> 00:08:42,990 +مرحلة الـ Blatlet Activation إنه صار لها Adhesion + +131 +00:08:42,990 --> 00:08:47,800 +بالـ Subendothelium الآنالخطوة الأولى اللى حكينا + +132 +00:08:47,800 --> 00:08:53,540 +عنها خطوة الـ Platelet Adhesion عبارة عن شغلة يعني + +133 +00:08:53,540 --> 00:08:58,640 +بدون طاقة مابتحتاجش ATP شغل تانى reversible يعني + +134 +00:08:58,640 --> 00:09:01,400 +أنا بعتبره Inertial Adhesion المرحلة اللى بعدها + +135 +00:09:01,400 --> 00:09:04,900 +الأهم اللى هى مرحلة الـ Platelet Aggregation الـ + +136 +00:09:04,900 --> 00:09:07,920 +Platelet Aggregation ليش بيصير؟ بيصير عشان الـ + +137 +00:09:07,920 --> 00:09:11,780 +Platelet بتجمع مع بعضهاوبعد ما تتجمع تروح و هي + +138 +00:09:11,780 --> 00:09:16,260 +مسكرة الجروح هي و الـ Fibrinogen بيرتبطوا مع بعض و + +139 +00:09:16,260 --> 00:09:21,540 +بيسددوا الجروح زي ما عندنا راح نشوف مع بعض هلأ كيف + +140 +00:09:21,540 --> 00:09:24,920 +بتصير عملية ال activation لـ Platelet Aggregation + +141 +00:09:24,920 --> 00:09:29,340 +في عندي مجموعة Agonist هترتبط مع ال Platelets عن + +142 +00:09:29,340 --> 00:09:33,080 +طريق Receptors على سطح ال Platelets كل Agonist له + +143 +00:09:33,080 --> 00:09:36,990 +Receptor خاص فيهزي الـ Adenosine زي الـ Collagen + +144 +00:09:36,990 --> 00:09:40,610 +زي الـ Thrombin برضه كلها دي Agonist إيش هتعمل؟ + +145 +00:09:40,610 --> 00:09:45,210 +لما بترتبط هيصير عندي سلسلة من التفاعلات بينتج + +146 +00:09:45,210 --> 00:09:51,770 +عنها مجموعة شغلات إيش بينتج؟ أول حاجة بيصير تحول + +147 +00:09:51,770 --> 00:09:55,050 +للـ Arachidonic Acid عن طريق الـ Cyclooxygenase + +148 +00:09:55,050 --> 00:09:58,950 +إلى Thromboxane-A2 Thromboxane-A2 هذا بعمل + +149 +00:09:58,950 --> 00:10:02,310 +activation للـ Platelets ولمّا تفرزق الـ Platelets + +150 +00:10:02,620 --> 00:10:06,560 +هيعمل activation لـ other platelets تمام الشغل + +151 +00:10:06,560 --> 00:10:10,560 +التاني هيصير degranulation للـ platelets البلاتلت + +152 +00:10:10,560 --> 00:10:14,220 +هتفرز الـ granules بتاعتها طبعاً هذا بيساعد على + +153 +00:10:14,220 --> 00:10:19,540 +أنه البلاتلت تانية تصير لها activation بالإضافة + +154 +00:10:19,540 --> 00:10:22,880 +لأنه في أشياء مهمة زي الـ fibrinogen زي هيك هذه + +155 +00:10:22,880 --> 00:10:26,980 +الأشياء الموجودة في الـ granules مهمة في عملية الـ + +156 +00:10:26,980 --> 00:10:32,080 +hemostasisشغلة تالتة مهمة برضه بتصير اللي هي بيصير + +157 +00:10:32,080 --> 00:10:34,860 +تغير في الـ Configuration للـ Receptor اللي على + +158 +00:10:34,860 --> 00:10:37,440 +سطح البلاتلت إيش هذا الـ Receptor؟ هذا الـ + +159 +00:10:37,440 --> 00:10:44,780 +Receptor اللي هو Alpha 2 B Beta 3 هذا + +160 +00:10:44,780 --> 00:10:48,460 +الـ Receptor هو اللي هيربط البلاتلت مع الـ + +161 +00:10:48,460 --> 00:10:51,700 +Fibrinogen فبيصير تغير في الـ Configuration بتاعه + +162 +00:10:51,700 --> 00:10:54,720 +بحيث أنه يصيرله Activation ويرتبط مع الـ + +163 +00:10:54,720 --> 00:10:58,860 +Fibrinogen هلقيت إذن؟الخلاصة إنه صار activation + +164 +00:10:58,860 --> 00:11:03,290 +للـ Plateletصار دي granulation صار تكون للـ + +165 +00:11:03,290 --> 00:11:07,450 +Thromboxane A2 شغل برضه مهم جدا أنه بيصير تغير في + +166 +00:11:07,450 --> 00:11:11,150 +شكل البلاتلت التغير في شكل البلاتلت فهذا بيساعد + +167 +00:11:11,150 --> 00:11:15,230 +على أنه يصير لها adhesion مع بعض أنه مساحة + +168 +00:11:15,230 --> 00:11:19,370 +الإلتصاق للبلاتلت مع بعضها تكون أوسع مما لو كانت + +169 +00:11:19,370 --> 00:11:22,630 +البلاتلت Discoid shape بتصير كأنه إصبايكي بيصير + +170 +00:11:22,630 --> 00:11:26,190 +لها نتوءات وزوائد هذه النتوءات بتزيد مساحة سطحها و + +171 +00:11:26,190 --> 00:11:30,430 +بتساعد على التشابكبصير activation لـ «الرسيبتور» + +172 +00:11:30,430 --> 00:11:35,990 +اللي هيرتبط مع الفترة النتيجة أو المحصلة زي ما + +173 +00:11:35,990 --> 00:11:39,970 +انتوا شايفين محصلة الخطوتين اللي حكينا عنهم قبلهاك + +174 +00:11:39,970 --> 00:11:46,610 +أنه أول حاجة البلاتلت ارتبطت بالـ subendothelial + +175 +00:11:46,610 --> 00:11:50,470 +tissue عن طريق الـ Van Wille Brand Factor في خطوة + +176 +00:11:50,470 --> 00:11:53,770 +الـ Adhesion المرحلة اللي بعدها اللي هي مرحلة الـ + +177 +00:11:53,770 --> 00:11:58,960 +Aggregation هتصير البلاتلت عاملة Bridgingمع بعض عن + +178 +00:11:58,960 --> 00:12:01,840 +طريق الـ Fibrinogen طبعا اللي بربطهم اللي هو الـ + +179 +00:12:01,840 --> 00:12:09,080 +Receptor Alpha-2B Beta-3 The cross-linking of two + +180 +00:12:09,080 --> 00:12:12,580 +or more platelets by Alpha-2B Beta-3 and + +181 +00:12:12,580 --> 00:12:15,800 +Fibrinogen is termed aggregation إذا صارت platelet + +182 +00:12:15,800 --> 00:12:19,200 +aggregation مع الـ Fibrinogen وهذه العملية اللي هي + +183 +00:12:19,200 --> 00:12:24,900 +هتساعد على تثبيتها برضه هنا يعني في عندي توضيح آخر + +184 +00:12:24,900 --> 00:12:29,840 +لإيش اللي بيصيراللي بيصير زي ما شوفنا إنه في عندي + +185 +00:12:29,840 --> 00:12:33,380 +مجموعة من الـ Agonist بترتبط طبعاً هذه المرحلة + +186 +00:12:33,380 --> 00:12:37,680 +مرحلة الـ Aggregation بتحتاج ATP زي ما حكينا بيصير + +187 +00:12:37,680 --> 00:12:40,400 +مجموعة من الـ Agonist بترتبط على سطح الـ Platelets + +188 +00:12:40,400 --> 00:12:43,660 +وبيصير activation لـ Platelets والـ Platelets + +189 +00:12:43,660 --> 00:12:46,360 +أساساً كانت مرتبطة بالـ Subendothelial tissue + +190 +00:12:46,360 --> 00:12:51,180 +طبعاً يعني هذا زي ملخص للكلام اللي حكيناه + +191 +00:12:55,170 --> 00:13:01,630 +طبعاً هنا هذه شريحة يعني بتحاول تربط وتبين لنا + +192 +00:13:01,630 --> 00:13:06,070 +يعني كيف ممكن البلاتلت activation برضه يأثر ويحفظ + +193 +00:13:06,070 --> 00:13:10,030 +ال secondary pathway لقيت عملية التحفيز اللي بتصير + +194 +00:13:10,030 --> 00:13:11,970 +له البلاتلت أو ال activation اللي بتصير له + +195 +00:13:11,970 --> 00:13:17,470 +البلاتلت بتقدر لإنه في نديق الفوسفاتيدال سيرين فده + +196 +00:13:17,470 --> 00:13:20,460 +عبارة عن فوسفه اللي بتشحنته سالبةالـ Phospholipid + +197 +00:13:20,460 --> 00:13:24,840 +هذا راح ينتقل إلى أو يتجمع عند السطح الخارجي للـ + +198 +00:13:24,840 --> 00:13:27,980 +Cell Membrane تاع الـ Platelet فبالتالي بتصير + +199 +00:13:27,980 --> 00:13:32,260 +الشحنة بتاعة الـ Platelets سالبة فلقيت شحنة الـ + +200 +00:13:32,260 --> 00:13:37,200 +Platelets السالبة هتعمل كعامل مساعد لبداية الـ + +201 +00:13:37,200 --> 00:13:40,620 +Intrinsic Pathway مظبوط فلقيت الـ Intrinsic + +202 +00:13:40,620 --> 00:13:46,330 +Pathway اتنشط هيكون لـ Thrombinلسرنبين هيعمل من + +203 +00:13:46,330 --> 00:13:51,510 +تاني كـ Agonist يحفظ البلاتلت وهكذا حفظت البلاتلت + +204 +00:13:51,510 --> 00:13:54,230 +زادت الـ Negative Charge وزاد الـ Intrinsic + +205 +00:13:54,230 --> 00:13:58,290 +Pathway فكلها عبارة عن حلقة متكاملة كل واحد فيهم + +206 +00:13:58,290 --> 00:14:04,390 +مسئول عن تنشيط شغلة أو شغلات كتير ننتقل للجزء + +207 +00:14:04,390 --> 00:14:07,910 +الثالث من مقونات الـ Hemostasis أو الأشياء اللي + +208 +00:14:07,910 --> 00:14:10,650 +بتساهم في حدوث الـ Hemostasis اللي هو الـ + +209 +00:14:10,650 --> 00:14:14,350 +Coagulation Factorالـ Coagulation factor بتمشي في + +210 +00:14:14,350 --> 00:14:19,650 +كسكايد بيبدأ بحدوث الجروح وينتهي بتكوين الفيبرين + +211 +00:14:19,650 --> 00:14:24,070 +في ما يسمى الـ Coagulation cascade الـ Coagulation + +212 +00:14:24,070 --> 00:14:28,470 +cascade يعني مش حاجة تم اكتشافها حديثا وانما هي في + +213 +00:14:28,470 --> 00:14:33,870 +ستنيات القرن الماضي حيث انه كان يعتقد ان الـ + +214 +00:14:33,870 --> 00:14:37,110 +Clotting عملية التجلط بتحصل عن طريق مجموعة من + +215 +00:14:37,110 --> 00:14:41,640 +التفاعلاتالتفاعلات هذه بتبدأ بتنشيط Serine + +216 +00:14:41,640 --> 00:14:45,220 +Protease Zymogens اللي هي احنا بنحكي عنها الـ + +217 +00:14:45,220 --> 00:14:50,780 +Coagulation Factors هذه الـ Factors طبعا بتتحول ل + +218 +00:14:50,780 --> 00:14:54,260 +Active Enzymes خطوة ورا خطوة يعني كل واحد مسئول عن + +219 +00:14:54,260 --> 00:14:58,920 +تنشيط الـ Enzyme اللي بعده في النهاية بنتهي ال + +220 +00:14:58,920 --> 00:15:04,100 +pathway بتكوين الفيبرينلفترات طويلة، ظل الاعتقاد + +221 +00:15:04,100 --> 00:15:06,900 +السائد إن الـ Intrinsic Pathway هو الـ more + +222 +00:15:06,900 --> 00:15:10,380 +important inkleting mechanism يعني ماكانوش ماخدين + +223 +00:15:10,380 --> 00:15:13,020 +في الحسبان موضوع الـ tissue factor مع factor VII + +224 +00:15:13,020 --> 00:15:16,540 +pathway اللي هو الـ Intrinsic Pathway لكن احنا + +225 +00:15:16,540 --> 00:15:20,240 +اليوم بنقول إنهم اتنين بيمشوا side by side، جنبا + +226 +00:15:20,240 --> 00:15:25,060 +جنبا طبعا عملية التجلط هذه أو عملية تكوين الفيبرين + +227 +00:15:25,060 --> 00:15:29,740 +بتبدأ بجروحالجروح هذا هيعمل activation للـ + +228 +00:15:29,740 --> 00:15:33,900 +Intrinsic Pathway و للـ Extrinsic Pathway تنتهي + +229 +00:15:33,900 --> 00:15:38,500 +هذه العملية في NDA الـ Coagulation Cascade خلينا + +230 +00:15:38,500 --> 00:15:42,800 +ناخد نظرة سريعة على الـ Coagulation Cascade زي ما + +231 +00:15:42,800 --> 00:15:47,340 +احنا عارفين هو عبارة عن بيمشي بطريقين بيمشي بطريق + +232 +00:15:47,340 --> 00:15:51,280 +الـ Intrinsic Pathway و Extrinsic Pathway هدول + +233 +00:15:51,280 --> 00:15:54,780 +التانين طبعا بيمشوا side by side تترنج عن بعض يعني + +234 +00:15:54,780 --> 00:15:59,390 +مافيش فيهم واحد بيسبق التانينجي للـ Intrinsic + +235 +00:15:59,390 --> 00:16:04,390 +Pathway الـ Intrinsic Pathway لما يصير exposure لـ + +236 +00:16:04,390 --> 00:16:08,730 +Sub-endothelial collagen هيعمل activation لـ + +237 +00:16:08,730 --> 00:16:12,610 +Factor 12 في وجود هيعمل activation لـ Factor 12 + +238 +00:16:12,610 --> 00:16:15,370 +الـ Factor 12 Active مع الـ Pre-Calicrine والـ + +239 +00:16:15,370 --> 00:16:17,890 +High Molecular Weight كاينينوجين هيعملوا + +240 +00:16:17,890 --> 00:16:22,480 +activation لـ Factor 11أول فاكتور حكينا عنه في الـ + +241 +00:16:22,480 --> 00:16:26,060 +Intrinsic فاكتور 12 بعدين فاكتور 11 بعد هيك + +242 +00:16:26,060 --> 00:16:29,720 +هيعملوا activation لفاكتور 9 تمام؟ هيعملوا + +243 +00:16:29,720 --> 00:16:33,800 +activation لفاكتور 9 المرحلة اللي بعدها اللي هي ال + +244 +00:16:33,800 --> 00:16:37,200 +activation لفاكتور 10 هلاقيت ال activation لفاكتور + +245 +00:16:37,200 --> 00:16:42,840 +10 بيصير عن طريق فاكتور 8 active فاكتور 8 active + +246 +00:16:42,840 --> 00:16:46,000 +مع الـ Platelet Phospholipid مع الكائن مع + +247 +00:16:46,000 --> 00:16:50,730 +الكالسيوم اللي هو فاكتور 4فدول بيقب يسيي يعني + +248 +00:16:50,730 --> 00:16:54,070 +بيعملوا ما يسمى بالـ Tennis Complex تننس كمبليكس + +249 +00:16:54,070 --> 00:16:57,530 +بعمل activation لفكرة عشرة عشان نبدأ ال common + +250 +00:16:57,530 --> 00:17:01,530 +pathwayبينما الـ Extrinsic Pathway برضه نتيجة + +251 +00:17:01,530 --> 00:17:04,790 +الجروح بيتكون عندى الـ Tissue Factor Tissue Factor + +252 +00:17:04,790 --> 00:17:08,970 +برتبط مع Factor 7 بيصير Activation لـ Factor 7 + +253 +00:17:08,970 --> 00:17:12,410 +Tissue Factor Factor 7 active مع لبلاتة + +254 +00:17:12,410 --> 00:17:16,030 +Phospholipid هدول هيقوموا بدور التنازق Complex + +255 +00:17:16,030 --> 00:17:21,190 +بحيث أنه هيعمل Activation مباشرة لـ Factor 10 إذن + +256 +00:17:21,190 --> 00:17:24,210 +Factor 10 صارله Activation بطريقين إما بالـ + +257 +00:17:24,210 --> 00:17:28,010 +Extrinsic Pathway أو بالـ Intrinsic Pathwayالـ + +258 +00:17:28,010 --> 00:17:31,410 +Extrinsic Pathway عدينا فيه بس فاكتور 7 وتشوفاكتور + +259 +00:17:31,410 --> 00:17:35,110 +بينما الـ Intrinsic Pathway عدينا فيه فاكتور 12 + +260 +00:17:35,110 --> 00:17:40,070 +فاكتور 11 فاكتور 9 فاكتور 8 والكالسيوم اللي هو + +261 +00:17:40,070 --> 00:17:45,290 +فاكتور 4 تمام فالإن سواء الـ Extrinsic Pathway أو + +262 +00:17:45,290 --> 00:17:47,730 +الـ Intrinsic Pathway اللي اتنشط من نتيجة حدوث + +263 +00:17:47,730 --> 00:17:51,990 +الجروح هيعملوا activation لفاكتور 10 فاللي فاكتور + +264 +00:17:51,990 --> 00:17:58,470 +10 الـ Activeهو اللي هيعمل activation لـThrombin + +265 +00:17:58,470 --> 00:18:03,270 +يعني هو هيحول الـ Prothrombin إلى Thrombin عن طريق + +266 +00:18:03,270 --> 00:18:06,690 +اللي هو ما يسمى بالـ Prothrombinase Complex اللي + +267 +00:18:06,690 --> 00:18:09,270 +هنا طبعا زي ما قلنا بنبدأ الـ Common Pathway الـ + +268 +00:18:09,270 --> 00:18:13,280 +Common Pathway بيبدأ factor X activeلما الـ Factor + +269 +00:18:13,280 --> 00:18:16,780 +X active في وجود الـ Platelet Phospholipid وفي + +270 +00:18:16,780 --> 00:18:20,700 +وجود الـ Calcium وفي وجود Factor V active زي ما + +271 +00:18:20,700 --> 00:18:23,980 +قولنا هذا بيسمي الـ Prothrombinase Complex بيحول + +272 +00:18:23,980 --> 00:18:27,000 +عند الـ Prothrombin إلى Ethrombin اللي هو إلى + +273 +00:18:27,000 --> 00:18:31,960 +Active Form الـ Ethrombin هيحول الـ Fibrinogen إلى + +274 +00:18:31,960 --> 00:18:36,500 +Fibrin Monomer بعد هيك Factor XIII هيصير له + +275 +00:18:36,500 --> 00:18:40,470 +Activationالـ Factor 13 هيعمل Stabilization لـ + +276 +00:18:40,470 --> 00:18:44,690 +Fibrin Monomer وهيحوله لـ Fibrin Polymer هيك + +277 +00:18:44,690 --> 00:18:50,670 +هيتكون عندى Stable Fibrin اللي هو هيساعد على .. في + +278 +00:18:50,670 --> 00:18:54,770 +الوضع الطبيعي طبعا في عندي Balance يعني لما بنحتاج + +279 +00:18:54,770 --> 00:18:58,890 +تكون ال Fibrin يتكون ال Fibrin وبيسكر الجروح بعد + +280 +00:18:58,890 --> 00:19:02,910 +هيك بتبدأ ال Fibrinolytic activity ال Fibrinolytic + +281 +00:19:02,910 --> 00:19:06,470 +activity بتكسر ال Fibrin اللي اتكون عشان ما تتكونش + +282 +00:19:06,470 --> 00:19:11,130 +جلطاتالان ممكن تتكون عندى thrombus أو جلطات في + +283 +00:19:11,130 --> 00:19:16,270 +حالتين إما بيصير abnormal activation لـ + +284 +00:19:16,270 --> 00:19:19,950 +coagulation cascade يعني مافيش داعي أنه يتنشط + +285 +00:19:19,950 --> 00:19:25,510 +وتنشط لسبب من الأسباب فبالتالي هتتكون thrombusفي + +286 +00:19:25,510 --> 00:19:30,010 +نفس الوقت ممكن يكون السبب إنه اتكونت الـ thrombus + +287 +00:19:30,010 --> 00:19:33,590 +لكن فيه خلل في الـ fibrinolytic activity يعني هذه + +288 +00:19:33,590 --> 00:19:36,430 +الـ thrombus اللي اتكونت ما اتحللت فبالتالي برضه + +289 +00:19:36,430 --> 00:19:40,170 +هذا الشخص بيكون عرضة لإنه يصير عنده جلطات in + +290 +00:19:40,170 --> 00:19:44,370 +contrast على النقيد حالات ال bleeding بتصير من إيش + +291 +00:19:44,370 --> 00:19:48,870 +حالات ال bleeding بتصير لو صار defect في ال + +292 +00:19:48,870 --> 00:19:51,370 +coagulation factor يعني في عندي مشكلة في ال + +293 +00:19:51,370 --> 00:19:55,550 +coagulation factor في ال process كلها بشكل عامأو + +294 +00:19:55,550 --> 00:20:00,050 +بسبب Accelerated Fibrinolysis يعني الفيبرينولايسيز + +295 +00:20:00,050 --> 00:20:03,170 +كانت سريعة جدا فبالتالي مجرد ما اتكون الفيبرين + +296 +00:20:03,170 --> 00:20:06,150 +مالحقش يقوم بالوظيفة تبعته كان صير له license + +297 +00:20:06,150 --> 00:20:10,250 +فبالتالي هذه الحالة أو هذه هتعمل عندنا طبعا + +298 +00:20:10,250 --> 00:20:13,150 +coagulation cascade هنا بقولك سواء intrinsic أو + +299 +00:20:13,150 --> 00:20:19,330 +extrinsic pathway هينشطولي ال common pathway نيجي + +300 +00:20:19,330 --> 00:20:23,350 +لل intrinsic pathway ال intrinsic pathwayزي ما + +301 +00:20:23,350 --> 00:20:27,410 +حكينا هو بيبدأ بالـActivation لـFactor 12 عن طريق + +302 +00:20:27,410 --> 00:20:30,930 +الـContact Factors الـContact Factors قد تكون + +303 +00:20:30,930 --> 00:20:33,730 +Negative لتشارج Phospholipid Surfaces زي الموجودة + +304 +00:20:33,730 --> 00:20:36,990 +في الـSubendothelial tissue اللي بتظهر في حالة + +305 +00:20:36,990 --> 00:20:41,150 +حدوث جروح في خارج الجسم ممكن تكون Glass أو Kowleen + +306 +00:20:41,150 --> 00:20:45,270 +أو أشياء تانية بتعطيني Negative Charge الـFactors + +307 +00:20:45,270 --> 00:20:50,140 +اللي بتتم تقييمها في هذا الـPathwayفاكتور 12، + +308 +00:20:50,140 --> 00:20:54,000 +فاكتور 11، فاكتور 9، فاكتور 8، precalcarin، high + +309 +00:20:54,000 --> 00:20:58,340 +molecular weight منقص الـ activity للـ intrinsic + +310 +00:20:58,340 --> 00:21:04,180 +هو ال pathway عن طريق الـ BTT هلقيت خلّيني أشوف + +311 +00:21:04,180 --> 00:21:09,380 +كيف الـ BTT نيجي للـ BTT قبل ما نحكي عن الـ BTT + +312 +00:21:09,380 --> 00:21:12,900 +بدنا نتذكر مع بعض العينة اللي كنا نسحبها كيف كنا + +313 +00:21:12,900 --> 00:21:16,920 +نسحبها و كيف كنا نتعامل معاها بشكل سريعفي فحوصات + +314 +00:21:16,920 --> 00:21:20,080 +الـ Hemostasis كنا نسحب عينة البلد في Sodium + +315 +00:21:20,080 --> 00:21:23,760 +Citrate كنا نستخدم الـ Anticoagulant اللي هو + +316 +00:21:23,760 --> 00:21:26,460 +Sodium Citrate Sodium Citrate هيعمل Capture + +317 +00:21:26,460 --> 00:21:30,480 +للكالسيوم فبالتالي هيمنع عملية الـ Coagulation + +318 +00:21:30,480 --> 00:21:35,240 +هلقيت العينة برضه إيش كنا نعمل فيها؟ كنا نعملها + +319 +00:21:35,240 --> 00:21:38,800 +centrifuge وقت طويل و نفصلها مرتين عسى إنه نتخلص + +320 +00:21:38,800 --> 00:21:42,600 +من الـ Platelet اللي فيها كنا نحصل على Platelet + +321 +00:21:42,600 --> 00:21:47,310 +Por Plasmaبمعنى إن عينة الـ Plasma اللي عندي لا + +322 +00:21:47,310 --> 00:21:51,550 +تحتوي على كالسيوم ولا تحتوي على بلاتلوس فوسفوليبيد + +323 +00:21:51,550 --> 00:21:55,290 +واتنين عاملين مهمين جداً في عملية الـ Coagulation + +324 +00:21:55,290 --> 00:21:58,150 +عشان هيك لو أنا بدي أعمل initiation للـ + +325 +00:21:58,150 --> 00:22:01,650 +Coagulation لازم أضيف الكالسيوم و لازم أضيف + +326 +00:22:01,650 --> 00:22:04,950 +الفوسفوليبيد فبالتالي أنا عشان أضمن أن الـ + +327 +00:22:04,950 --> 00:22:09,130 +Intrinsic pathway هو اللي بدي يبدأ عندى بشغل + +328 +00:22:09,130 --> 00:22:14,170 +الاتفاعل كالتالي بضيف عليهcontact activator + +329 +00:22:14,170 --> 00:22:18,870 +وphospholipid تمام بعد هيك بضيف ال calcium ال + +330 +00:22:18,870 --> 00:22:21,850 +calcium يعتبر ك initiator اللي هو اللي بدي أبدأ + +331 +00:22:21,850 --> 00:22:24,730 +عندي ال reaction لما بضيف ال calcium ببدأ أحسب أو + +332 +00:22:24,730 --> 00:22:29,210 +بشغل stopwatch و ببدأ أحسب قداش الوقت اللازم لتكون + +333 +00:22:29,210 --> 00:22:33,890 +ال fiber in equilibrium طبعا هذا الفحص لأنه احنا + +334 +00:22:33,890 --> 00:22:37,650 +شغلنا ال intrinsic pathway هيشيك على أي خلل في ال + +335 +00:22:37,650 --> 00:22:42,440 +intrinsic and common pathwayهندي ملاحظة هنا إنه في + +336 +00:22:42,440 --> 00:22:44,620 +عندي بعض الـ «دراجز» زي الـ «هيبارين» والـ + +337 +00:22:44,620 --> 00:22:47,620 +«وافارين» في عندي الـ «فاكتر إنهيبتر» اللي هو بس + +338 +00:22:47,620 --> 00:22:53,120 +Anticoagulant عادة تعمل prolongation للـ BTT طيب + +339 +00:22:53,120 --> 00:22:56,440 +نيجي للـ Intrinsic Pathway اللي هو الـ Tissue + +340 +00:22:56,440 --> 00:23:00,880 +Factor Pathway عادة هذا لما بيصير جروح بطلع الـ + +341 +00:23:00,880 --> 00:23:06,360 +Tissue Factor الـ Tissue Factor هيعمل activation + +342 +00:23:06,360 --> 00:23:08,980 +لـ «فاكتر 7» هيرتبط مع «فاكتر 7» الـ Active + +343 +00:23:09,300 --> 00:23:12,720 +وبالتالي يعمل activation لـ Factor 10 ويبدأ عندي + +344 +00:23:12,720 --> 00:23:16,720 +بعدها الـ Common Pathway بتم تقييم الـ Extrinsic + +345 +00:23:16,720 --> 00:23:23,580 +Pathway عن طريق فحص الـ BT فحص + +346 +00:23:23,580 --> 00:23:28,520 +الـ BT أنا بدي أشغل فيه الـ Extrinsic Pathway مش + +347 +00:23:28,520 --> 00:23:32,820 +الـ Intrinsic Pathway فبجيب مادة زي الـ tissue + +348 +00:23:32,820 --> 00:23:36,620 +factor اللي هي طبعا هي tissue factor لكنممكن يكون + +349 +00:23:36,620 --> 00:23:40,120 +لها أكتر من مصدر مش شرط تكون من الـ Human يعني وإن + +350 +00:23:40,120 --> 00:23:44,220 +كان الأفضل اللي هو الـ Human tissue factor بجيب + +351 +00:23:44,220 --> 00:23:46,900 +الـ Thromboplastin اللي هو الـ tissue factor بضيفه + +352 +00:23:46,900 --> 00:23:49,840 +على العينة مع الكالسيوم فهيبدأ ال pathway هنا + +353 +00:23:49,840 --> 00:23:53,120 +هيبدأ ال Extrinsic pathway ليش؟ لأني أنا حطيتله ال + +354 +00:23:53,120 --> 00:23:58,060 +tissue factor طبعاً بعمل initiation و بشوف الوقت + +355 +00:23:58,060 --> 00:24:03,720 +اللازم لتكونهنا هيشيك عندي على الـ Extrinsic + +356 +00:24:03,720 --> 00:24:08,820 +Factors والـ Common Pathway Factors اللي هو الـ BT + +357 +00:24:08,820 --> 00:24:12,400 +الـ + +358 +00:24:12,400 --> 00:24:15,340 +Common Pathway الـ Common Pathway هتشتغل فيه + +359 +00:24:15,340 --> 00:24:19,580 +فاكتور 5، فاكتور 10، فاكتور 13، فاكتور 2 زي ما + +360 +00:24:19,580 --> 00:24:22,800 +أنتوا شايفين في عندي التنازق Complex هيعمل + +361 +00:24:22,800 --> 00:24:26,600 +Activation هذا جاي من الـ Intrinsic Pathway هيعمل + +362 +00:24:26,600 --> 00:24:31,050 +Activation لهفاكتور عشرة وبعدين بيجي البروثروم + +363 +00:24:31,050 --> 00:24:34,550 +بنيز Complex وبيكمل عندى لغاية ما يتكون عندى الـ + +364 +00:24:34,550 --> 00:24:38,590 +Fibrin Polymer اتوقع ان الـ BT أو الـ BTT بكشف + +365 +00:24:38,590 --> 00:24:41,710 +عندى اذا كان فيه خلل في الـ Common Pathway وعادة + +366 +00:24:41,710 --> 00:24:44,330 +اذا كان فيه خلل في الـ Factors بتاعت ال Common + +367 +00:24:44,330 --> 00:24:52,190 +Pathway هيتأثر التانين هيتأثر عندى الـ BT و الـ + +368 +00:24:52,190 --> 00:24:52,470 +BTT + +369 +00:24:55,680 --> 00:24:59,040 +طبعاً هندي هذا الـ Cascade ملخص بيوضح فيه الـ + +370 +00:24:59,040 --> 00:25:01,720 +Intrinsic و الـ Extrinsic pathway و الـ Common + +371 +00:25:01,720 --> 00:25:08,340 +pathway طيب هلقات احنا حكينا عن الـ Coagulation + +372 +00:25:08,340 --> 00:25:12,840 +cascade زي ما في عندي Coagulation cascade في عندي + +373 +00:25:12,840 --> 00:25:16,520 +Anti-coagulant pathway هلقات عملية الـ Coagulation + +374 +00:25:16,520 --> 00:25:21,820 +مش لازم تضل شغالة على طول لازم تيجي أشياء توقف + +375 +00:25:21,820 --> 00:25:25,190 +عملية الـ Coagulationففي عندي أكتر من pathway في + +376 +00:25:25,190 --> 00:25:30,490 +عندي الـ antithrombine pathway في عندي protein C + +377 +00:25:30,490 --> 00:25:33,250 +-thrombomodulin pathway في عندي tissue factor + +378 +00:25:33,250 --> 00:25:37,090 +مثلما أنتوا شايفين في عندي أكتر من anticoagulant + +379 +00:25:37,090 --> 00:25:41,850 +pathway في عندي ال tissue factor pathway inhibitor + +380 +00:25:41,850 --> 00:25:45,050 +في عندي ال antithrombin 3 + +381 +00:25:47,610 --> 00:25:51,650 +طيب نيجي لأول pathway اللي هي في الـ Anti + +382 +00:25:51,650 --> 00:25:54,410 +-coagulation اللي هي الـ Anti-thrombin pathway + +383 +00:25:54,410 --> 00:25:59,090 +Anti-thrombin يعتبر أهم inhibitor لـ coagulation + +384 +00:25:59,090 --> 00:26:05,130 +للثرمبين بيشكل حوالي 80% of ثرمبين inhibitory + +385 +00:26:05,130 --> 00:26:10,190 +activity in plasma يعني هو أهم pathway عندنا الـ + +386 +00:26:10,190 --> 00:26:13,790 +Anti-thrombin عادة بيعمل inhibition directly + +387 +00:26:14,470 --> 00:26:18,810 +للثرمبين ولفاكتور عشرة بالإضافة فاكتور عشرة active + +388 +00:26:18,810 --> 00:26:22,490 +طبعا هو لما يعمل inhibition للثرمبين ولفاكتور عشرة + +389 +00:26:22,490 --> 00:26:25,750 +أكيد هيتوقف ال pathway لأن هذه ال factors المفروضة + +390 +00:26:25,750 --> 00:26:30,010 +تقوم بدورها لكن هو طالما عمللها block مش هيتكمل ال + +391 +00:26:30,010 --> 00:26:33,230 +pathway وبالتالي مش هيتكون الفيبرين وهكذا هو يقوم + +392 +00:26:33,230 --> 00:26:39,650 +بدوره ك anticoagulant طيب نشوف تفاصيل أكتر عن + +393 +00:26:39,650 --> 00:26:45,550 +الموضوع ال antithrombinبعمل inhibition زي ما قلنا + +394 +00:26:45,550 --> 00:26:49,950 +بشكل مباشر أو بشكل أساسي للاثرنبين ولا factor 10 + +395 +00:26:49,950 --> 00:26:52,830 +active بالإضافة لأنه بعمل inhibition ل other + +396 +00:26:52,830 --> 00:26:58,050 +factors زي factor 9 active، factor 11، factor 12 + +397 +00:26:58,050 --> 00:27:03,430 +active بعمل inhibition لل complement enzyme C1 كيف + +398 +00:27:03,430 --> 00:27:07,530 +بتصير عملية ال inhibition لما بيصير جروح بتطلع + +399 +00:27:07,530 --> 00:27:11,150 +مادة الهيبرانسلفات هذه المادة بتطلع من ال + +400 +00:27:11,150 --> 00:27:15,970 +endothelial cellsمادة شبيهة بالـ Heparin هذه + +401 +00:27:15,970 --> 00:27:22,210 +المادة راح تروح و هي مرتبطة بالـ Antithrombin لما + +402 +00:27:22,210 --> 00:27:26,950 +بترتبط فيه بتعمل له conformational changes بتغير + +403 +00:27:26,950 --> 00:27:31,970 +الشكل أو التركيبة بتاعته بحيث أنه يصير سهل عليه + +404 +00:27:31,970 --> 00:27:36,550 +أنه يرتبط بالإنزيم أو بالإنزايم و يعمله + +405 +00:27:36,550 --> 00:27:40,880 +inactivationThis facilitated its reaction with the + +406 +00:27:40,880 --> 00:27:43,560 +enzyme أنتثرومبين form a complex with the + +407 +00:27:43,560 --> 00:27:47,200 +inhibited proteins بعد هي ارتبط مع الانزيم اللي + +408 +00:27:47,200 --> 00:27:52,560 +صارله هنا هذه ميكانيزم بسيطة ورسم تخطيتي بسيط جدا + +409 +00:27:52,560 --> 00:27:57,320 +بيوضح عندي كيف ارتباط الانتثرومبين مع الهيبرين أو + +410 +00:27:57,320 --> 00:28:01,000 +مع الهيبرانسالفات بيغير ال confirmation لإله بيصير + +411 +00:28:01,000 --> 00:28:04,940 +موائم لارتباط بال active factors خلّيني أشوف هلأ + +412 +00:28:04,940 --> 00:28:10,680 +هاي عندنا الهيبرينفي عندى الـ Antithrombin ارتباط + +413 +00:28:10,680 --> 00:28:13,920 +الهيبرين مع الـ Antithrombin هيغير شكل الـ + +414 +00:28:13,920 --> 00:28:19,040 +Antithrombin شفتين كيف صار شكله؟ فهذا الشكل هيصير + +415 +00:28:19,040 --> 00:28:23,640 +موائم لشكل factor 10 active و factor 2 active اللي + +416 +00:28:23,640 --> 00:28:26,860 +هو الـ Thrombin وبالتالي هيصير ارتباط بينهم و + +417 +00:28:26,860 --> 00:28:30,640 +هيصير هذا ال factor اللي كان active هيصير inactive + +418 +00:28:32,100 --> 00:28:35,440 +الرسمة اللي معكم هيها الرسمة اللي معكم في الملزمة + +419 +00:28:35,440 --> 00:28:39,100 +خلينا نشوف إيش فيها في عندي الـ Antithrombine + +420 +00:28:39,100 --> 00:28:41,920 +والهيبرين لما يرتبط الـ Antithrombine بالهيبرين + +421 +00:28:41,920 --> 00:28:46,920 +بصير موائم لارتباط للثرمبين بعد هيك بنفك الهيبرين + +422 +00:28:46,920 --> 00:28:53,560 +فبالتالي هيتكون عندي Complex من ال factor اللي صار + +423 +00:28:53,560 --> 00:28:59,310 +inactive مع الـ Antithrombine وهيك بنكوننيجي للـ + +424 +00:28:59,310 --> 00:29:03,030 +pathway التاني اللي هو protein C pathway خلّوا + +425 +00:29:03,030 --> 00:29:06,530 +بالكم إحنا بنحكي عن anticoagulant pathway يعني + +426 +00:29:06,530 --> 00:29:10,810 +هيمشي الكسكيت ويكون عندي الـ coagulation factors + +427 +00:29:10,810 --> 00:29:14,770 +الـ active وحتى تبدأ تتكون الفيبرين هلأ في مرحلة + +428 +00:29:14,770 --> 00:29:17,910 +معينة لازم الكسكيت هذا يبدأ يشتغلله الـ + +429 +00:29:17,910 --> 00:29:22,390 +anticoagulant عشان يوقف الـ coagulation أو يقلل من + +430 +00:29:22,390 --> 00:29:26,670 +الـ coagulation إيش اللي بصير؟ لما بزيد في ثرمبين + +431 +00:29:27,500 --> 00:29:31,220 +نتيجة الـ activation لـ Coagulation cascade + +432 +00:29:31,220 --> 00:29:35,720 +الثرمبين هذا هيروح يرتبط مع الـ Thrombomodulin + +433 +00:29:35,720 --> 00:29:41,240 +ثرمبوموديولين هذا موجود على الـ Endothelium هيكون + +434 +00:29:41,240 --> 00:29:46,980 +ثرمبين ثرمبوموديولين Complex هذا الـ Complex هيعمل + +435 +00:29:46,980 --> 00:29:52,820 +activation لبروتين C البروتين C هيصير Active + +436 +00:29:52,820 --> 00:29:57,390 +بروتين C فلقيت لما بيصير activation لبروتين Cهيروح + +437 +00:29:57,390 --> 00:30:00,190 +الـ «بروتين C» يرتبط مع «cofactor» اللي هو «بروتين + +438 +00:30:00,190 --> 00:30:05,150 +S» ومع «factor V» inactive فلقيت ال «complex» اللي + +439 +00:30:05,150 --> 00:30:08,590 +اتوان عندي أكتر «بروتين C» و«بروتين S» و«factor V» + +440 +00:30:08,590 --> 00:30:11,910 +inactive هيعملوا «inactivation» لـ «factor VIII» + +441 +00:30:11,910 --> 00:30:17,570 +و«inactivation» لـ «factor V» وهيك هيوقفوا تكون + +442 +00:30:17,570 --> 00:30:22,660 +الـ «Thrombin»تمام؟ لأنه زي ما انتوا عارفين فاكتور + +443 +00:30:22,660 --> 00:30:27,760 +5 هو جزء أساسي في الـ Thrombinase Complex و فاكتور + +444 +00:30:27,760 --> 00:30:31,360 +8 جزء أساسي في التمنازل Complex فطالما صار ان + +445 +00:30:31,360 --> 00:30:36,280 +اكتشف هذه زي ما انتوا شايفين الاثرومبين اتكون + +446 +00:30:36,280 --> 00:30:41,700 +نتيجة طبعا بدت تتكون ال clot ومش الكسكاد وزاد + +447 +00:30:41,700 --> 00:30:45,380 +الاثرومبين في ال blood زيادة الاثرومبين حيرضت مع + +448 +00:30:45,380 --> 00:30:49,400 +الاثرومبوموديولينهيعمل أثرومبين أثرومبوموديولين + +449 +00:30:49,400 --> 00:30:53,440 +Complex هدول إيش راح يعملوا؟ راح يعملوا activation + +450 +00:30:53,440 --> 00:31:01,260 +لبروتين C هيتكون عندى active بروتين C طبعا اتكونت + +451 +00:31:01,260 --> 00:31:04,880 +الأثرومبس عليها factor 5 active و عليها factor 8 + +452 +00:31:04,880 --> 00:31:13,640 +active هيجي بروتين C ال active طبعا بمساعدة بروتين + +453 +00:31:13,640 --> 00:31:19,820 +Sهيعملوا الـ Factor 8 Active هيتحول لـ Factor 8 + +454 +00:31:19,820 --> 00:31:26,780 +Inactive برضه هنا هيصير عندى بمساعدة Factor 5 + +455 +00:31:26,780 --> 00:31:29,860 +هيصير Inactivation لـ Factor 5 فبالتالي هيتوقف + +456 +00:31:29,860 --> 00:31:33,320 +Factor 5 و Factor 8 الـ Active هيصير لهم + +457 +00:31:33,320 --> 00:31:37,680 +Inactivation و هيتوقف الـ Cascade هنا بيحكي لنا + +458 +00:31:37,680 --> 00:31:42,890 +أنه فين أشياء بتعتبر كـ Co-factors لـ Protein Sلـ + +459 +00:31:42,890 --> 00:31:46,550 +Protein C عفواً اللي هي Protein S و Factor 5 الـ + +460 +00:31:46,550 --> 00:31:49,690 +Protein S بيساعد الـ Active Protein C على إنه + +461 +00:31:49,690 --> 00:31:52,190 +يرتبط مع الـ Phospholipids بتاعة الـ Platelets و + +462 +00:31:52,190 --> 00:31:55,810 +الـ Endothelium الـ Protein S اللي بيشتغل لازم + +463 +00:31:55,810 --> 00:32:00,790 +يكون Free لكن قريب من 60% من الـ Protein S بنلاقي + +464 +00:32:00,790 --> 00:32:07,430 +مرتبط بـ C4B Binding Protein Factor 5 مع Protein S + +465 +00:32:07,430 --> 00:32:12,870 +طبعاً زي ما قلنا بيخلوا الـ Active Protein Cيعمل + +466 +00:32:12,870 --> 00:32:18,410 +degradation لـ factor 8 و factor 9 نيجي للميكانيزم + +467 +00:32:18,410 --> 00:32:23,970 +الثالث اللي هو tissue factor pathway inhibitor هذا + +468 +00:32:23,970 --> 00:32:27,750 +بيطلع من الـ endothelium لما بيصير activation لل + +469 +00:32:27,750 --> 00:32:32,450 +pathway لل factors برتبط مع factor 10 active + +470 +00:32:32,450 --> 00:32:36,990 +بيعملوا complex factor 10 active معTissue Factor + +471 +00:32:36,990 --> 00:32:40,850 +Pathway Inhibitor ويروح ويرتبطه بتعوني الـ + +472 +00:32:40,850 --> 00:32:44,430 +Extrinsic Pathway الـ Tissue Factor مع Factor 7 + +473 +00:32:44,430 --> 00:32:48,350 +Active وبالتالي بعمل Inactivation للـ Extrinsic + +474 +00:32:48,350 --> 00:32:53,370 +Pathway طيب + +475 +00:32:53,370 --> 00:32:57,830 +نيجي للـ Fibrinolytic Pathway طبعا احنا بمجرد ما + +476 +00:32:57,830 --> 00:33:01,630 +الفيبرين يتكون هتبدأ عملية الـ Fibrinolysis لأن هو + +477 +00:33:01,630 --> 00:33:04,670 +بده يقدّي وظيفة وينتهي مش لازم يظل موجود في الجسم + +478 +00:33:05,630 --> 00:33:11,530 +طبعاً في عندى بلازمينوجين البلازمينوجين هذا هو + +479 +00:33:11,530 --> 00:33:15,310 +اللى بتتحول لبلازمين وبيعمل على تكسير الـ fibrin + +480 +00:33:15,310 --> 00:33:19,690 +اللى اتكون البلازمينوجين بده يصيرله activation إما + +481 +00:33:19,690 --> 00:33:22,610 +بيصيرله in vivo عن طريق اتمشه بلازمينوجين + +482 +00:33:22,610 --> 00:33:27,330 +activator هذا بيجي من الـ Indothelium أو عن طريق + +483 +00:33:27,330 --> 00:33:32,690 +اليوركيناز بلازمينوجين activator ممكن يكون اكسوجنس + +484 +00:33:32,880 --> 00:33:36,080 +عن طريق الـ streptokinase اللي بينعطل المرضى اللي + +485 +00:33:36,080 --> 00:33:41,940 +عندهم جلطات عشان يتدوب الجلطات كلهم بيشتغل على الـ + +486 +00:33:41,940 --> 00:33:44,540 +plasminogen بيعملوا activation بيحولوا إلى + +487 +00:33:44,540 --> 00:33:49,960 +البلازمين البلازمين هذا هيعمل degradation للفيبرين + +488 +00:33:49,960 --> 00:33:54,280 +وعلى الفيبرينوجين لو شغل على الفيبرينوجين هيعطيني + +489 +00:33:54,280 --> 00:33:57,740 +D-dimer لكن لو شغل على الفيبرينوجين مش هيعطي D + +490 +00:33:57,740 --> 00:34:01,480 +-dimer علشان هيك الـD-dimer ارتفاع ودليل على انه + +491 +00:34:01,480 --> 00:34:06,720 +فيهطلعوا معايا Degradation of fibrin and + +492 +00:34:06,720 --> 00:34:09,700 +fibrinogen «فيبرين» or «فيبرين» «فيبرينوجين» or + +493 +00:34:09,700 --> 00:34:10,780 +«فيبرين» «فيبرين» or «فيبرين» «فيبرينوجين» or + +494 +00:34:10,780 --> 00:34:14,280 +«فيبرين» «فيبرينوجين» or «فيبرين» «فيبرينوجين» + +495 +00:34:14,280 --> 00:34:14,980 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +496 +00:34:14,980 --> 00:34:15,040 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +497 +00:34:15,040 --> 00:34:15,820 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +498 +00:34:15,820 --> 00:34:18,080 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +499 +00:34:18,080 --> 00:34:25,460 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» «فيبرينوج + +500 +00:34:31,020 --> 00:34:33,780 +لغاية ما في النهاية يصير complete degradation + +501 +00:34:33,780 --> 00:34:38,980 +لإلهم الآن كيف بدنا نعمل evaluation لـFibrinolysis + +502 +00:34:38,980 --> 00:34:44,300 +إذا كان فعلا صار فيه اتكوّن fibriniclot وصار لها + +503 +00:34:44,300 --> 00:34:48,700 +degradation هنلاقي الـD-dimer ارتفع في blood إذا + +504 +00:34:48,700 --> 00:34:51,160 +وجود الـD-dimer قد يعطي + +505 +00:35:00,380 --> 00:35:04,640 +الـ Pulmonary embolism الـ DIC في حالات الـ Normal + +506 +00:35:04,640 --> 00:35:07,160 +الـ Pregnancy و لو صار فيه Complication في ال + +507 +00:35:07,160 --> 00:35:10,280 +pregnancy هتلاقي ال level تاعه ارتفع بشكل كبير و + +508 +00:35:10,280 --> 00:35:10,780 +ملحوظ + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.json b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..05b66a246f4ed0ab7f08dc81ba5f64c3209a8f1a --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2062, "start": 0.88, "end": 20.62, "text": "بسم الله الرحمن الرحيم محاضرتنا ان شاء الله راح تكون Introduction to Special Hemostasis أو Coagulation عملية الـ Hemostasis عادة بتبدأ بحدوث جروح معين لما بيحلث الجروح بتتكون لـ Clot", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 3714, 5016, 46958, 43500, 8315, 16472, 13412, 16606, 21984, 12602, 39319, 6055, 30544, 27193, 882, 281, 11863, 18568, 555, 26632, 34051, 3066, 559, 2776, 6225, 42213, 10632, 2423, 39184, 18568, 555, 26632, 6225, 18513, 3660, 39894, 44510, 10721, 4724, 24401, 2407, 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الـ BT أو الـ BTT بكشف عندى اذا كان فيه خلل في الـ Common Pathway وعادة اذا كان فيه خلل في الـ Factors بتاعت ال Common Pathway هيتأثر التانين هيتأثر عندى الـ BT و الـ BTT", "tokens": [5172, 995, 4117, 2655, 13063, 6225, 8592, 25720, 46599, 22488, 9957, 4724, 1829, 7435, 1829, 2423, 26890, 2407, 12984, 2288, 20498, 4724, 22653, 11622, 41184, 4032, 21292, 24793, 1211, 43242, 7578, 5296, 17082, 995, 10632, 19446, 7251, 2655, 30544, 43242, 7578, 2423, 39184, 479, 6414, 259, 18553, 936, 1975, 2655, 30543, 3615, 16472, 2423, 39184, 31144, 34051, 2423, 39184, 363, 28178, 4724, 4117, 8592, 5172, 43242, 7578, 1975, 15730, 25961, 8978, 3224, 16490, 1211, 1211, 8978, 2423, 39184, 18235, 21914, 676, 4032, 3615, 18513, 3660, 1975, 15730, 25961, 8978, 3224, 16490, 1211, 1211, 8978, 2423, 39184, 33375, 830, 39894, 995, 34268, 2423, 18235, 21914, 676, 8032, 36081, 10721, 49115, 16712, 7649, 9957, 8032, 36081, 10721, 49115, 43242, 7578, 2423, 39184, 31144, 4032, 2423, 39184, 363, 28178], "avg_logprob": 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" inhibition", "probability": 0.813720703125}, {"start": 1625.03, "end": 1626.11, "word": " لما", "probability": 0.605712890625}, {"start": 1626.11, "end": 1626.49, "word": " بيصير", "probability": 0.891357421875}, {"start": 1626.49, "end": 1626.95, "word": " جروح", "probability": 0.9456380208333334}, {"start": 1626.95, "end": 1627.53, "word": " بتطلع", "probability": 0.9107666015625}, {"start": 1627.53, "end": 1628.03, "word": " مادة", "probability": 0.9759114583333334}, {"start": 1628.03, "end": 1629.23, "word": " الهيبرانسلفات", "probability": 0.752105712890625}, {"start": 1629.23, "end": 1629.53, "word": " هذه", "probability": 0.86962890625}, {"start": 1629.53, "end": 1629.89, "word": " المادة", "probability": 0.9873046875}, {"start": 1629.89, "end": 1630.41, "word": " بتطلع", "probability": 0.8831787109375}, {"start": 1630.41, "end": 1630.75, "word": " من", "probability": 0.9951171875}, {"start": 1630.75, "end": 1631.15, "word": " ال", "probability": 0.96728515625}, {"start": 1631.15, "end": 1631.75, "word": " endothelial", "probability": 0.8388671875}, {"start": 1631.75, "end": 1632.15, "word": " cells", "probability": 0.8544921875}], "temperature": 1.0}, {"id": 64, "seek": 165753, "start": 1632.79, "end": 1657.53, "text": "مادة شبيهة بالـ Heparin هذه المادة راح تروح و هي مرتبطة بالـ Antithrombin لما بترتبط فيه بتعمل له conformational changes بتغير الشكل أو التركيبة بتاعته بحيث أنه يصير سهل عليه أنه يرتبط بالإنزيم أو بالإنزايم و يعمله inactivation", "tokens": [2304, 18513, 3660, 13412, 21292, 3224, 3660, 20666, 39184, 634, 2181, 259, 29538, 9673, 18513, 3660, 12602, 39319, 6055, 32887, 5016, 4032, 39896, 3714, 43500, 3555, 9566, 3660, 20666, 39184, 5130, 355, 4397, 13496, 5296, 15042, 39894, 43500, 3555, 9566, 8978, 3224, 39894, 25957, 1211, 46740, 18975, 1478, 2962, 39894, 17082, 13546, 25124, 28820, 34051, 16712, 31747, 1829, 49401, 39894, 995, 34268, 3224, 4724, 5016, 1829, 12984, 14739, 3224, 7251, 9381, 13546, 8608, 3224, 1211, 47356, 14739, 3224, 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2108.44, "word": " level", "probability": 0.70654296875}, {"start": 2108.44, "end": 2108.82, "word": " تاعه", "probability": 0.6429850260416666}, {"start": 2108.82, "end": 2109.14, "word": " ارتفع", "probability": 0.9161376953125}, {"start": 2109.14, "end": 2109.58, "word": " بشكل", "probability": 0.9939778645833334}, {"start": 2109.58, "end": 2110.12, "word": " كبير", "probability": 0.9884440104166666}, {"start": 2110.12, "end": 2110.28, "word": " و", "probability": 0.98828125}, {"start": 2110.28, "end": 2110.78, "word": " ملحوظ", "probability": 0.91826171875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2111.228, "duration_after_vad": 2065.964374999995} \ No newline at end of file diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..3c7d4610e8c0b360bd6b587c6080e81f14ceed8b --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/jLrVDXI7fbo_raw.srt @@ -0,0 +1,2032 @@ +1 +00:00:00,880 --> 00:00:04,800 +بسم الله الرحمن الرحيم محاضرتنا ان شاء الله راح + +2 +00:00:04,800 --> 00:00:08,400 +تكون Introduction to Special Hemostasis أو + +3 +00:00:08,400 --> 00:00:12,540 +Coagulation عملية + +4 +00:00:12,540 --> 00:00:18,180 +الـ Hemostasis عادة بتبدأ بحدوث جروح معين لما + +5 +00:00:18,180 --> 00:00:23,090 +بيحلث الجروح بتتكون لـ Clotالأن لما بتتكون لـ Clot + +6 +00:00:23,090 --> 00:00:26,370 +أكيد راح يصير الشغل اللي بعدها Clot Dissolution + +7 +00:00:26,370 --> 00:00:29,690 +لأن الـ Clot دي مش لازم تظل موجودة في مكانها لازم + +8 +00:00:29,690 --> 00:00:32,670 +يصير لها تحليل وإلا بيصير الـ Thrombosis بيصير + +9 +00:00:32,670 --> 00:00:37,870 +تجلطات عشان هيك تعتبر عملية الـ Hemostasis أنه + +10 +00:00:37,870 --> 00:00:41,490 +بيحدث فيها Balance ما بين Clot Formation and Clot + +11 +00:00:41,490 --> 00:00:46,110 +Dissolution موضوع الـ Hemostasis طبعاً بيساهم في + +12 +00:00:46,110 --> 00:00:51,600 +ثلاث أشياء مهمة ال Vasculature Coagulationنحكي + +13 +00:00:51,600 --> 00:00:55,040 +بداية عن الـ Blood vessels لما بنحكي عن الـ Blood + +14 +00:00:55,040 --> 00:00:58,800 +vessels أكتر شئ بهمني فيها اللي هو الـ Endothelium + +15 +00:00:58,800 --> 00:01:04,380 +المبطن لإلها الـ Endothelium هذا الصحيح هو يعني + +16 +00:01:04,380 --> 00:01:08,800 +يُعتبر Dynamic Organ إيش يعني Dynamic Organ إبارة + +17 +00:01:08,800 --> 00:01:15,540 +عن جزء أو Organ عملي كيف يعني عملي بيقدر يتأقلم + +18 +00:01:15,540 --> 00:01:20,890 +ويغير وظيفته حسبالبيئة المحيطة فيه يعني على سبيل + +19 +00:01:20,890 --> 00:01:24,670 +المثال في جروح هو بدي أقلم حاله إنه يسكر الجروح + +20 +00:01:24,670 --> 00:01:30,050 +فبصير يعطي أشياء تساعد على تسكير الجروح بصير يساعد + +21 +00:01:30,050 --> 00:01:33,330 +على تكوين الجلطة يساعد على البلاتلة aggregation و + +22 +00:01:33,330 --> 00:01:36,890 +adhesion بيساعد على إنه يصير vasoconstriction + +23 +00:01:36,890 --> 00:01:41,730 +بيعطي مواد تضيق لـ blood vessel الآن مافيش عندنا + +24 +00:01:41,730 --> 00:01:45,470 +جروح هو بطبيعته بيكون thromboresistant إيش يعني + +25 +00:01:45,470 --> 00:01:50,110 +thromboresistant؟الـ Endothelial نفسه يعني مانع + +26 +00:01:50,110 --> 00:01:53,710 +لتكوين الجلطات يمنع التصاق لـ Platelet فيه عمق + +27 +00:01:53,710 --> 00:01:56,010 +وإنه يصير Platelet adhesion and aggregation + +28 +00:01:56,010 --> 00:01:59,490 +بالإضافة لإنه بيمنع عملية الـ Thrombosis فبالتالي + +29 +00:01:59,490 --> 00:02:03,770 +هو حسب البيئة المحيطة فيه هيشتغل حسب الظرف اللي هو + +30 +00:02:03,770 --> 00:02:07,430 +فيه هيغير وظيفته و هيفرز مواد مختلفة يعني هنلاقي + +31 +00:02:07,430 --> 00:02:11,530 +إنه بيفرز أشياء ممكن تعمل كـ Stimulators و أشياء + +32 +00:02:11,530 --> 00:02:15,200 +هتعمل Inhibitorsفي حاجات هتعمل Vasoconstriction + +33 +00:02:15,200 --> 00:02:20,240 +وفي حاجات هتعمل Vasodilation وظائف الـ Vascular + +34 +00:02:20,240 --> 00:02:24,300 +Endothelium أو بعض الأشياء اللي بيفرزها ونشوف إيش + +35 +00:02:24,300 --> 00:02:27,600 +وظيفتها زي أن مثلا الـ Prostacycline الـ + +36 +00:02:27,600 --> 00:02:30,080 +Prostacycline هذا بيعمل في الوضع الطبيعي + +37 +00:02:30,080 --> 00:02:32,560 +Vasodilation لأنه أنا بدي ال blood vessel في الوضع + +38 +00:02:32,560 --> 00:02:36,100 +الطبيعي بدون جروح يبقى متسع و ال blood يمشي + +39 +00:02:36,100 --> 00:02:39,840 +بأرياحيةشغلة تانية Inhibition of platelet + +40 +00:02:39,840 --> 00:02:42,700 +aggregation وهذا اللي أنا بدياه بالوضع الطبيعي أنا + +41 +00:02:42,700 --> 00:02:45,840 +مابدي يصير platelet aggregation الـ Thrombocytin + +42 +00:02:45,840 --> 00:02:49,280 +A2 هذا بتكون لـ platelets بعمل construction لـ + +43 +00:02:49,280 --> 00:02:54,660 +blood vessels أو لـ muscular arteries في عندي + +44 +00:02:54,660 --> 00:02:58,900 +شغلات أخرى زي الـ ELAMs and ICAMs هذه عبارة عن + +45 +00:02:58,900 --> 00:03:05,260 +cytokines بيفرزها الـ endotheliumالـ cytokines هذه + +46 +00:03:05,260 --> 00:03:09,500 +إلها علاقة في جذب الـ white bcs إلى مكان ال + +47 +00:03:09,500 --> 00:03:13,080 +inflammation والتصاقها فيه فبالتالي هو إيه وإيه + +48 +00:03:13,080 --> 00:03:16,420 +علاقة بال inflammatory process الـ von و ال brand + +49 +00:03:16,420 --> 00:03:20,520 +factor طبعا مهم جدا في التصاق لـ platelets مع ال + +50 +00:03:20,520 --> 00:03:26,190 +subendothelial collagenالشغلات تانية ممكن يعطيها + +51 +00:03:26,190 --> 00:03:32,990 +زي الـ Tissue Factor Pathway Inhibitors في عندى زى + +52 +00:03:32,990 --> 00:03:36,530 +ما أنتوا عارفين لما بتكون الـ Fibrin فالنهاية أنا + +53 +00:03:36,530 --> 00:03:39,130 +بدى أوقف عملية الـ Coagulation خلاص مابديها تظل + +54 +00:03:39,130 --> 00:03:42,390 +مستمرة للأبد لازم توقف قد وظيفته وتكون الـ Fibrin + +55 +00:03:42,390 --> 00:03:46,240 +لازم توقف العملية هذهفبالتالي بتطلع عندي مواد + +56 +00:03:46,240 --> 00:03:49,300 +بتعمل كـ Anticoagulant من الـ Anticoagulants هذه و + +57 +00:03:49,300 --> 00:03:52,120 +اللي بيساهم الـ Endothelium في تكوينها اللي هو الـ + +58 +00:03:52,120 --> 00:03:56,560 +Tesiofactor Pathway Inhibitor هذا بيوقف الـ + +59 +00:03:56,560 --> 00:03:59,420 +Coagulation عن طريق توقيف الـ Extrinsic Pathway + +60 +00:03:59,420 --> 00:04:03,200 +راح نشوف لقدام كيف فيه أن الـ Thrombomodulin، + +61 +00:04:03,200 --> 00:04:05,780 +Thrombomodulin هذا بيعمل Inhibition للـ + +62 +00:04:05,780 --> 00:04:08,780 +Coagulation عن طريق الـ Activation للـ Protein C + +63 +00:04:08,780 --> 00:04:13,130 +System اللي بدوره بيوقف الـ Coagulationفي عند الـ + +64 +00:04:13,130 --> 00:04:16,530 +Tissue Plasminogen Activator طبعاً الـ Plasminogen + +65 +00:04:16,530 --> 00:04:21,670 +هذا بيبدأ عملية الـ Fibrinolysis فبالتالي هو بيشجع + +66 +00:04:21,670 --> 00:04:25,050 +الـ Fibrinolysis في أن الهيبرينسالفات + +67 +00:04:25,050 --> 00:04:28,370 +البروتيوجلاكان برضه من الأشياء اللي بيفرزها هذا + +68 +00:04:28,370 --> 00:04:33,350 +بيعمل Inhibition لل-coagulation by activation of + +69 +00:04:33,350 --> 00:04:36,730 +antithrombine يعني بنشط الـ antithrombine فبالتالي + +70 +00:04:36,730 --> 00:04:40,420 +بيعمل كـ Anticoagulantبالإضافة لأنه بيعطينا الـ + +71 +00:04:40,420 --> 00:04:43,120 +tissue factor الـ tissue factor بيرتبط إلى factor + +72 +00:04:43,120 --> 00:04:49,260 +7 وبيعمل initiation للextrinsic pathway يعني هنا + +73 +00:04:49,260 --> 00:04:55,120 +كـ anticoagulant شغال و كprocoagulant نيجي للـ + +74 +00:04:55,120 --> 00:04:58,380 +blood platelets البلاتلتز زي ما احنا عارفين هي + +75 +00:04:58,380 --> 00:05:02,280 +بتتكون من الـ cytoplasm للبوم مارو ميجا كاريوسايت + +76 +00:05:02,280 --> 00:05:06,080 +طبعا هي أصغر واحدة في ال blood cells أو ال + +77 +00:05:06,080 --> 00:05:09,500 +component elements بتاعة ال bloodالوضع الطبيعي لها + +78 +00:05:09,500 --> 00:05:15,060 +عددها يتروح ما بين 150 إلى 450 ألف شكلها disk + +79 +00:05:15,060 --> 00:05:19,320 +shape a enucleated cell with complex internal + +80 +00:05:19,320 --> 00:05:23,440 +structure يعني في تركيبها الداخل المعقد يعكس ما + +81 +00:05:23,440 --> 00:05:26,020 +تقوم به من وظيفة في الهيموستاسس + +82 +00:05:29,330 --> 00:05:33,910 +طيب لـ Platelets أهم حاجة في تركيبها اللي هي الـ + +83 +00:05:33,910 --> 00:05:36,450 +Granules اللي موجودة فيها اللي بتقوم بالوظائف + +84 +00:05:36,450 --> 00:05:38,670 +المهمة في الـ Hemostasis في عندنا الـ Alpha + +85 +00:05:38,670 --> 00:05:42,530 +Granules وفي عندنا الـ Densy Granules الـ Alpha + +86 +00:05:42,530 --> 00:05:46,350 +Granules إيش محتوياتها؟ هيكون فيها بعض الـ + +87 +00:05:46,350 --> 00:05:49,630 +Coagulation Factors زي الـ Fibrinogen، Vinyl Brand + +88 +00:05:49,630 --> 00:05:53,990 +Factor فيها الـ Coagulation Factor خمسة و تمانية + +89 +00:05:53,990 --> 00:05:58,460 +فيها كمان Platelet Derived Growth Factorفي عند الـ + +90 +00:05:58,460 --> 00:06:03,120 +Densy Granules الـ Densy Granules صميت هيك لأن هيك + +91 +00:06:03,120 --> 00:06:06,180 +بتظهر في الـ electron microscope هذه بتحتوي على + +92 +00:06:06,180 --> 00:06:09,620 +الـ ATP وبتحتوي على الـ ADP وبتحتوي على + +93 +00:06:09,620 --> 00:06:13,900 +السيروتونين الـ Granules هذه بيصيرلها release في + +94 +00:06:13,900 --> 00:06:19,140 +حالة البلاتلت activation هنا + +95 +00:06:19,140 --> 00:06:22,620 +عندنا صورة بتوضح أهم إشي يعني بتوضح تركيبة + +96 +00:06:22,620 --> 00:06:26,520 +البلاتلت أهم إشي بيهمني اللي هي ال .. ال .. ال .. + +97 +00:06:26,520 --> 00:06:30,520 +ال ..اللي هي الـ Density Granules والـ Alpha-A + +98 +00:06:30,520 --> 00:06:33,920 +Granules هيهم وهي محتوياتهم واضحين عندنا بالصورة + +99 +00:06:33,920 --> 00:06:36,940 +طيب، + +100 +00:06:36,940 --> 00:06:42,480 +نشوف الآن كيف بيصير الـ Platelet Activate خلينا + +101 +00:06:42,480 --> 00:06:46,740 +نتخيل blood vessel وعاء دموي الوعاء الدموي هذا + +102 +00:06:46,740 --> 00:06:49,960 +عادة بيكون مبطن بالـ Endothelial اللي هو الخط + +103 +00:06:49,960 --> 00:06:54,780 +الأحمر فيه تحت منه الـ Subendothelial اللي هو الخط + +104 +00:06:54,780 --> 00:06:59,220 +المتقطع الأبيض اللي باينهلقيت في الوضع الطبيعي هي + +105 +00:06:59,220 --> 00:07:01,780 +البلاد اللي تماشية في الـ blood vessel في عندي + +106 +00:07:01,780 --> 00:07:07,560 +coagulation factors في عندي يعني integral + +107 +00:07:07,560 --> 00:07:11,840 +integrated اندوثيليام شايفين كيف الاندوثيليام هنا + +108 +00:07:11,840 --> 00:07:15,340 +متكامل هلقيت صار جروح تخيلوا على الجهة التانية صار + +109 +00:07:15,340 --> 00:07:19,520 +عندي جروح الجروح هذا هيعمل exposing للـsub + +110 +00:07:19,520 --> 00:07:24,340 +endothelial الـsub endothelial هذا هيصير باين + +111 +00:07:24,340 --> 00:07:29,500 +وظاهرفبالتالي الآن هتبدأ عملية ارتباط لـ Platelets + +112 +00:07:29,500 --> 00:07:32,460 +بالـ Subendothelium عشان تعمل Platelet Adhesion + +113 +00:07:32,460 --> 00:07:35,720 +على الهامش، في عندي هنا Release للـ Tissue Factor + +114 +00:07:35,720 --> 00:07:38,440 +الـ Tissue Factor هنا مش هيلزمني في الـ Extrinsic + +115 +00:07:38,440 --> 00:07:43,520 +Pathway لكن هو بيقولك يعني إنه الـ Sub … برضه الـ + +116 +00:07:43,520 --> 00:07:47,820 +Endothelium بيساعد على الـ Release للـ Tissue + +117 +00:07:47,820 --> 00:07:51,560 +Factor اللي بيساعد في سيكندرية مستهزة، تمام؟ + +118 +00:07:51,560 --> 00:07:55,840 +خلّينا في موضوع إنه صار جروح، صار Injuryصار + +119 +00:07:55,840 --> 00:07:58,740 +Exposing للـ Subendothelial خلّيني نشوف إيش بيصير + +120 +00:07:58,740 --> 00:08:03,240 +هلقت + +121 +00:08:03,240 --> 00:08:07,060 +الجروح هيطلع عندي Von Willebrand Factor الـ Von + +122 +00:08:07,060 --> 00:08:10,340 +Willebrand Factor هذا راح يربط البلاتلت مع الـ + +123 +00:08:10,340 --> 00:08:14,860 +Subendothelial tissue كيف؟ عن طريق ريسبتر على صفح + +124 +00:08:14,860 --> 00:08:20,190 +البلاتلت اللي هو Glycoprotein 1Bهذا هو اللي بتم من + +125 +00:08:20,190 --> 00:08:23,950 +خلاله ارتباط البلاتلت مع الـ Von والـ Brand Factor + +126 +00:08:23,950 --> 00:08:28,550 +اللي بدوره بيمسك البلاتلت على الـ Subendothelial + +127 +00:08:28,550 --> 00:08:32,850 +tissue وهذه مرحلة الـ Initial Blatlet Activation + +128 +00:08:32,850 --> 00:08:36,550 +بحيث أنه يصير Adhesion للبلاتلت مع الـ + +129 +00:08:36,550 --> 00:08:39,490 +Subendothelium تمام؟ إذن هي المرحلة الأولى في + +130 +00:08:39,490 --> 00:08:42,990 +مرحلة الـ Blatlet Activation إنه صار لها Adhesion + +131 +00:08:42,990 --> 00:08:47,800 +بالـ Subendothelium الآنالخطوة الأولى اللى حكينا + +132 +00:08:47,800 --> 00:08:53,540 +عنها خطوة الـ Platelet Adhesion عبارة عن شغلة يعني + +133 +00:08:53,540 --> 00:08:58,640 +بدون طاقة مابتحتاجش ATP شغل تانى reversible يعني + +134 +00:08:58,640 --> 00:09:01,400 +أنا بعتبره Inertial Adhesion المرحلة اللى بعدها + +135 +00:09:01,400 --> 00:09:04,900 +الأهم اللى هى مرحلة الـ Platelet Aggregation الـ + +136 +00:09:04,900 --> 00:09:07,920 +Platelet Aggregation ليش بيصير؟ بيصير عشان الـ + +137 +00:09:07,920 --> 00:09:11,780 +Platelet بتجمع مع بعضهاوبعد ما تتجمع تروح و هي + +138 +00:09:11,780 --> 00:09:16,260 +مسكرة الجروح هي و الـ Fibrinogen بيرتبطوا مع بعض و + +139 +00:09:16,260 --> 00:09:21,540 +بيسددوا الجروح زي ما عندنا راح نشوف مع بعض هلأ كيف + +140 +00:09:21,540 --> 00:09:24,920 +بتصير عملية ال activation لـ Platelet Aggregation + +141 +00:09:24,920 --> 00:09:29,340 +في عندي مجموعة Agonist هترتبط مع ال Platelets عن + +142 +00:09:29,340 --> 00:09:33,080 +طريق Receptors على سطح ال Platelets كل Agonist له + +143 +00:09:33,080 --> 00:09:36,990 +Receptor خاص فيهزي الـ Adenosine زي الـ Collagen + +144 +00:09:36,990 --> 00:09:40,610 +زي الـ Thrombin برضه كلها دي Agonist إيش هتعمل؟ + +145 +00:09:40,610 --> 00:09:45,210 +لما بترتبط هيصير عندي سلسلة من التفاعلات بينتج + +146 +00:09:45,210 --> 00:09:51,770 +عنها مجموعة شغلات إيش بينتج؟ أول حاجة بيصير تحول + +147 +00:09:51,770 --> 00:09:55,050 +للـ Arachidonic Acid عن طريق الـ Cyclooxygenase + +148 +00:09:55,050 --> 00:09:58,950 +إلى Thromboxane-A2 Thromboxane-A2 هذا بعمل + +149 +00:09:58,950 --> 00:10:02,310 +activation للـ Platelets ولمّا تفرزق الـ Platelets + +150 +00:10:02,620 --> 00:10:06,560 +هيعمل activation لـ other platelets تمام الشغل + +151 +00:10:06,560 --> 00:10:10,560 +التاني هيصير degranulation للـ platelets البلاتلت + +152 +00:10:10,560 --> 00:10:14,220 +هتفرز الـ granules بتاعتها طبعاً هذا بيساعد على + +153 +00:10:14,220 --> 00:10:19,540 +أنه البلاتلت تانية تصير لها activation بالإضافة + +154 +00:10:19,540 --> 00:10:22,880 +لأنه في أشياء مهمة زي الـ fibrinogen زي هيك هذه + +155 +00:10:22,880 --> 00:10:26,980 +الأشياء الموجودة في الـ granules مهمة في عملية الـ + +156 +00:10:26,980 --> 00:10:32,080 +hemostasisشغلة تالتة مهمة برضه بتصير اللي هي بيصير + +157 +00:10:32,080 --> 00:10:34,860 +تغير في الـ Configuration للـ Receptor اللي على + +158 +00:10:34,860 --> 00:10:37,440 +سطح البلاتلت إيش هذا الـ Receptor؟ هذا الـ + +159 +00:10:37,440 --> 00:10:44,780 +Receptor اللي هو Alpha 2 B Beta 3 هذا + +160 +00:10:44,780 --> 00:10:48,460 +الـ Receptor هو اللي هيربط البلاتلت مع الـ + +161 +00:10:48,460 --> 00:10:51,700 +Fibrinogen فبيصير تغير في الـ Configuration بتاعه + +162 +00:10:51,700 --> 00:10:54,720 +بحيث أنه يصيرله Activation ويرتبط مع الـ + +163 +00:10:54,720 --> 00:10:58,860 +Fibrinogen هلقيت إذن؟الخلاصة إنه صار activation + +164 +00:10:58,860 --> 00:11:03,290 +للـ Plateletصار دي granulation صار تكون للـ + +165 +00:11:03,290 --> 00:11:07,450 +Thromboxane A2 شغل برضه مهم جدا أنه بيصير تغير في + +166 +00:11:07,450 --> 00:11:11,150 +شكل البلاتلت التغير في شكل البلاتلت فهذا بيساعد + +167 +00:11:11,150 --> 00:11:15,230 +على أنه يصير لها adhesion مع بعض أنه مساحة + +168 +00:11:15,230 --> 00:11:19,370 +الإلتصاق للبلاتلت مع بعضها تكون أوسع مما لو كانت + +169 +00:11:19,370 --> 00:11:22,630 +البلاتلت Discoid shape بتصير كأنه إصبايكي بيصير + +170 +00:11:22,630 --> 00:11:26,190 +لها نتوءات وزوائد هذه النتوءات بتزيد مساحة سطحها و + +171 +00:11:26,190 --> 00:11:30,430 +بتساعد على التشابكبصير activation لـ «الرسيبتور» + +172 +00:11:30,430 --> 00:11:35,990 +اللي هيرتبط مع الفترة النتيجة أو المحصلة زي ما + +173 +00:11:35,990 --> 00:11:39,970 +انتوا شايفين محصلة الخطوتين اللي حكينا عنهم قبلهاك + +174 +00:11:39,970 --> 00:11:46,610 +أنه أول حاجة البلاتلت ارتبطت بالـ subendothelial + +175 +00:11:46,610 --> 00:11:50,470 +tissue عن طريق الـ Van Wille Brand Factor في خطوة + +176 +00:11:50,470 --> 00:11:53,770 +الـ Adhesion المرحلة اللي بعدها اللي هي مرحلة الـ + +177 +00:11:53,770 --> 00:11:58,960 +Aggregation هتصير البلاتلت عاملة Bridgingمع بعض عن + +178 +00:11:58,960 --> 00:12:01,840 +طريق الـ Fibrinogen طبعا اللي بربطهم اللي هو الـ + +179 +00:12:01,840 --> 00:12:09,080 +Receptor Alpha-2B Beta-3 The cross-linking of two + +180 +00:12:09,080 --> 00:12:12,580 +or more platelets by Alpha-2B Beta-3 and + +181 +00:12:12,580 --> 00:12:15,800 +Fibrinogen is termed aggregation إذا صارت platelet + +182 +00:12:15,800 --> 00:12:19,200 +aggregation مع الـ Fibrinogen وهذه العملية اللي هي + +183 +00:12:19,200 --> 00:12:24,900 +هتساعد على تثبيتها برضه هنا يعني في عندي توضيح آخر + +184 +00:12:24,900 --> 00:12:29,840 +لإيش اللي بيصيراللي بيصير زي ما شوفنا إنه في عندي + +185 +00:12:29,840 --> 00:12:33,380 +مجموعة من الـ Agonist بترتبط طبعاً هذه المرحلة + +186 +00:12:33,380 --> 00:12:37,680 +مرحلة الـ Aggregation بتحتاج ATP زي ما حكينا بيصير + +187 +00:12:37,680 --> 00:12:40,400 +مجموعة من الـ Agonist بترتبط على سطح الـ Platelets + +188 +00:12:40,400 --> 00:12:43,660 +وبيصير activation لـ Platelets والـ Platelets + +189 +00:12:43,660 --> 00:12:46,360 +أساساً كانت مرتبطة بالـ Subendothelial tissue + +190 +00:12:46,360 --> 00:12:51,180 +طبعاً يعني هذا زي ملخص للكلام اللي حكيناه + +191 +00:12:55,170 --> 00:13:01,630 +طبعاً هنا هذه شريحة يعني بتحاول تربط وتبين لنا + +192 +00:13:01,630 --> 00:13:06,070 +يعني كيف ممكن البلاتلت activation برضه يأثر ويحفظ + +193 +00:13:06,070 --> 00:13:10,030 +ال secondary pathway لقيت عملية التحفيز اللي بتصير + +194 +00:13:10,030 --> 00:13:11,970 +له البلاتلت أو ال activation اللي بتصير له + +195 +00:13:11,970 --> 00:13:17,470 +البلاتلت بتقدر لإنه في نديق الفوسفاتيدال سيرين فده + +196 +00:13:17,470 --> 00:13:20,460 +عبارة عن فوسفه اللي بتشحنته سالبةالـ Phospholipid + +197 +00:13:20,460 --> 00:13:24,840 +هذا راح ينتقل إلى أو يتجمع عند السطح الخارجي للـ + +198 +00:13:24,840 --> 00:13:27,980 +Cell Membrane تاع الـ Platelet فبالتالي بتصير + +199 +00:13:27,980 --> 00:13:32,260 +الشحنة بتاعة الـ Platelets سالبة فلقيت شحنة الـ + +200 +00:13:32,260 --> 00:13:37,200 +Platelets السالبة هتعمل كعامل مساعد لبداية الـ + +201 +00:13:37,200 --> 00:13:40,620 +Intrinsic Pathway مظبوط فلقيت الـ Intrinsic + +202 +00:13:40,620 --> 00:13:46,330 +Pathway اتنشط هيكون لـ Thrombinلسرنبين هيعمل من + +203 +00:13:46,330 --> 00:13:51,510 +تاني كـ Agonist يحفظ البلاتلت وهكذا حفظت البلاتلت + +204 +00:13:51,510 --> 00:13:54,230 +زادت الـ Negative Charge وزاد الـ Intrinsic + +205 +00:13:54,230 --> 00:13:58,290 +Pathway فكلها عبارة عن حلقة متكاملة كل واحد فيهم + +206 +00:13:58,290 --> 00:14:04,390 +مسئول عن تنشيط شغلة أو شغلات كتير ننتقل للجزء + +207 +00:14:04,390 --> 00:14:07,910 +الثالث من مقونات الـ Hemostasis أو الأشياء اللي + +208 +00:14:07,910 --> 00:14:10,650 +بتساهم في حدوث الـ Hemostasis اللي هو الـ + +209 +00:14:10,650 --> 00:14:14,350 +Coagulation Factorالـ Coagulation factor بتمشي في + +210 +00:14:14,350 --> 00:14:19,650 +كسكايد بيبدأ بحدوث الجروح وينتهي بتكوين الفيبرين + +211 +00:14:19,650 --> 00:14:24,070 +في ما يسمى الـ Coagulation cascade الـ Coagulation + +212 +00:14:24,070 --> 00:14:28,470 +cascade يعني مش حاجة تم اكتشافها حديثا وانما هي في + +213 +00:14:28,470 --> 00:14:33,870 +ستنيات القرن الماضي حيث انه كان يعتقد ان الـ + +214 +00:14:33,870 --> 00:14:37,110 +Clotting عملية التجلط بتحصل عن طريق مجموعة من + +215 +00:14:37,110 --> 00:14:41,640 +التفاعلاتالتفاعلات هذه بتبدأ بتنشيط Serine + +216 +00:14:41,640 --> 00:14:45,220 +Protease Zymogens اللي هي احنا بنحكي عنها الـ + +217 +00:14:45,220 --> 00:14:50,780 +Coagulation Factors هذه الـ Factors طبعا بتتحول ل + +218 +00:14:50,780 --> 00:14:54,260 +Active Enzymes خطوة ورا خطوة يعني كل واحد مسئول عن + +219 +00:14:54,260 --> 00:14:58,920 +تنشيط الـ Enzyme اللي بعده في النهاية بنتهي ال + +220 +00:14:58,920 --> 00:15:04,100 +pathway بتكوين الفيبرينلفترات طويلة، ظل الاعتقاد + +221 +00:15:04,100 --> 00:15:06,900 +السائد إن الـ Intrinsic Pathway هو الـ more + +222 +00:15:06,900 --> 00:15:10,380 +important inkleting mechanism يعني ماكانوش ماخدين + +223 +00:15:10,380 --> 00:15:13,020 +في الحسبان موضوع الـ tissue factor مع factor VII + +224 +00:15:13,020 --> 00:15:16,540 +pathway اللي هو الـ Intrinsic Pathway لكن احنا + +225 +00:15:16,540 --> 00:15:20,240 +اليوم بنقول إنهم اتنين بيمشوا side by side، جنبا + +226 +00:15:20,240 --> 00:15:25,060 +جنبا طبعا عملية التجلط هذه أو عملية تكوين الفيبرين + +227 +00:15:25,060 --> 00:15:29,740 +بتبدأ بجروحالجروح هذا هيعمل activation للـ + +228 +00:15:29,740 --> 00:15:33,900 +Intrinsic Pathway و للـ Extrinsic Pathway تنتهي + +229 +00:15:33,900 --> 00:15:38,500 +هذه العملية في NDA الـ Coagulation Cascade خلينا + +230 +00:15:38,500 --> 00:15:42,800 +ناخد نظرة سريعة على الـ Coagulation Cascade زي ما + +231 +00:15:42,800 --> 00:15:47,340 +احنا عارفين هو عبارة عن بيمشي بطريقين بيمشي بطريق + +232 +00:15:47,340 --> 00:15:51,280 +الـ Intrinsic Pathway و Extrinsic Pathway هدول + +233 +00:15:51,280 --> 00:15:54,780 +التانين طبعا بيمشوا side by side تترنج عن بعض يعني + +234 +00:15:54,780 --> 00:15:59,390 +مافيش فيهم واحد بيسبق التانينجي للـ Intrinsic + +235 +00:15:59,390 --> 00:16:04,390 +Pathway الـ Intrinsic Pathway لما يصير exposure لـ + +236 +00:16:04,390 --> 00:16:08,730 +Sub-endothelial collagen هيعمل activation لـ + +237 +00:16:08,730 --> 00:16:12,610 +Factor 12 في وجود هيعمل activation لـ Factor 12 + +238 +00:16:12,610 --> 00:16:15,370 +الـ Factor 12 Active مع الـ Pre-Calicrine والـ + +239 +00:16:15,370 --> 00:16:17,890 +High Molecular Weight كاينينوجين هيعملوا + +240 +00:16:17,890 --> 00:16:22,480 +activation لـ Factor 11أول فاكتور حكينا عنه في الـ + +241 +00:16:22,480 --> 00:16:26,060 +Intrinsic فاكتور 12 بعدين فاكتور 11 بعد هيك + +242 +00:16:26,060 --> 00:16:29,720 +هيعملوا activation لفاكتور 9 تمام؟ هيعملوا + +243 +00:16:29,720 --> 00:16:33,800 +activation لفاكتور 9 المرحلة اللي بعدها اللي هي ال + +244 +00:16:33,800 --> 00:16:37,200 +activation لفاكتور 10 هلاقيت ال activation لفاكتور + +245 +00:16:37,200 --> 00:16:42,840 +10 بيصير عن طريق فاكتور 8 active فاكتور 8 active + +246 +00:16:42,840 --> 00:16:46,000 +مع الـ Platelet Phospholipid مع الكائن مع + +247 +00:16:46,000 --> 00:16:50,730 +الكالسيوم اللي هو فاكتور 4فدول بيقب يسيي يعني + +248 +00:16:50,730 --> 00:16:54,070 +بيعملوا ما يسمى بالـ Tennis Complex تننس كمبليكس + +249 +00:16:54,070 --> 00:16:57,530 +بعمل activation لفكرة عشرة عشان نبدأ ال common + +250 +00:16:57,530 --> 00:17:01,530 +pathwayبينما الـ Extrinsic Pathway برضه نتيجة + +251 +00:17:01,530 --> 00:17:04,790 +الجروح بيتكون عندى الـ Tissue Factor Tissue Factor + +252 +00:17:04,790 --> 00:17:08,970 +برتبط مع Factor 7 بيصير Activation لـ Factor 7 + +253 +00:17:08,970 --> 00:17:12,410 +Tissue Factor Factor 7 active مع لبلاتة + +254 +00:17:12,410 --> 00:17:16,030 +Phospholipid هدول هيقوموا بدور التنازق Complex + +255 +00:17:16,030 --> 00:17:21,190 +بحيث أنه هيعمل Activation مباشرة لـ Factor 10 إذن + +256 +00:17:21,190 --> 00:17:24,210 +Factor 10 صارله Activation بطريقين إما بالـ + +257 +00:17:24,210 --> 00:17:28,010 +Extrinsic Pathway أو بالـ Intrinsic Pathwayالـ + +258 +00:17:28,010 --> 00:17:31,410 +Extrinsic Pathway عدينا فيه بس فاكتور 7 وتشوفاكتور + +259 +00:17:31,410 --> 00:17:35,110 +بينما الـ Intrinsic Pathway عدينا فيه فاكتور 12 + +260 +00:17:35,110 --> 00:17:40,070 +فاكتور 11 فاكتور 9 فاكتور 8 والكالسيوم اللي هو + +261 +00:17:40,070 --> 00:17:45,290 +فاكتور 4 تمام فالإن سواء الـ Extrinsic Pathway أو + +262 +00:17:45,290 --> 00:17:47,730 +الـ Intrinsic Pathway اللي اتنشط من نتيجة حدوث + +263 +00:17:47,730 --> 00:17:51,990 +الجروح هيعملوا activation لفاكتور 10 فاللي فاكتور + +264 +00:17:51,990 --> 00:17:58,470 +10 الـ Activeهو اللي هيعمل activation لـThrombin + +265 +00:17:58,470 --> 00:18:03,270 +يعني هو هيحول الـ Prothrombin إلى Thrombin عن طريق + +266 +00:18:03,270 --> 00:18:06,690 +اللي هو ما يسمى بالـ Prothrombinase Complex اللي + +267 +00:18:06,690 --> 00:18:09,270 +هنا طبعا زي ما قلنا بنبدأ الـ Common Pathway الـ + +268 +00:18:09,270 --> 00:18:13,280 +Common Pathway بيبدأ factor X activeلما الـ Factor + +269 +00:18:13,280 --> 00:18:16,780 +X active في وجود الـ Platelet Phospholipid وفي + +270 +00:18:16,780 --> 00:18:20,700 +وجود الـ Calcium وفي وجود Factor V active زي ما + +271 +00:18:20,700 --> 00:18:23,980 +قولنا هذا بيسمي الـ Prothrombinase Complex بيحول + +272 +00:18:23,980 --> 00:18:27,000 +عند الـ Prothrombin إلى Ethrombin اللي هو إلى + +273 +00:18:27,000 --> 00:18:31,960 +Active Form الـ Ethrombin هيحول الـ Fibrinogen إلى + +274 +00:18:31,960 --> 00:18:36,500 +Fibrin Monomer بعد هيك Factor XIII هيصير له + +275 +00:18:36,500 --> 00:18:40,470 +Activationالـ Factor 13 هيعمل Stabilization لـ + +276 +00:18:40,470 --> 00:18:44,690 +Fibrin Monomer وهيحوله لـ Fibrin Polymer هيك + +277 +00:18:44,690 --> 00:18:50,670 +هيتكون عندى Stable Fibrin اللي هو هيساعد على .. في + +278 +00:18:50,670 --> 00:18:54,770 +الوضع الطبيعي طبعا في عندي Balance يعني لما بنحتاج + +279 +00:18:54,770 --> 00:18:58,890 +تكون ال Fibrin يتكون ال Fibrin وبيسكر الجروح بعد + +280 +00:18:58,890 --> 00:19:02,910 +هيك بتبدأ ال Fibrinolytic activity ال Fibrinolytic + +281 +00:19:02,910 --> 00:19:06,470 +activity بتكسر ال Fibrin اللي اتكون عشان ما تتكونش + +282 +00:19:06,470 --> 00:19:11,130 +جلطاتالان ممكن تتكون عندى thrombus أو جلطات في + +283 +00:19:11,130 --> 00:19:16,270 +حالتين إما بيصير abnormal activation لـ + +284 +00:19:16,270 --> 00:19:19,950 +coagulation cascade يعني مافيش داعي أنه يتنشط + +285 +00:19:19,950 --> 00:19:25,510 +وتنشط لسبب من الأسباب فبالتالي هتتكون thrombusفي + +286 +00:19:25,510 --> 00:19:30,010 +نفس الوقت ممكن يكون السبب إنه اتكونت الـ thrombus + +287 +00:19:30,010 --> 00:19:33,590 +لكن فيه خلل في الـ fibrinolytic activity يعني هذه + +288 +00:19:33,590 --> 00:19:36,430 +الـ thrombus اللي اتكونت ما اتحللت فبالتالي برضه + +289 +00:19:36,430 --> 00:19:40,170 +هذا الشخص بيكون عرضة لإنه يصير عنده جلطات in + +290 +00:19:40,170 --> 00:19:44,370 +contrast على النقيد حالات ال bleeding بتصير من إيش + +291 +00:19:44,370 --> 00:19:48,870 +حالات ال bleeding بتصير لو صار defect في ال + +292 +00:19:48,870 --> 00:19:51,370 +coagulation factor يعني في عندي مشكلة في ال + +293 +00:19:51,370 --> 00:19:55,550 +coagulation factor في ال process كلها بشكل عامأو + +294 +00:19:55,550 --> 00:20:00,050 +بسبب Accelerated Fibrinolysis يعني الفيبرينولايسيز + +295 +00:20:00,050 --> 00:20:03,170 +كانت سريعة جدا فبالتالي مجرد ما اتكون الفيبرين + +296 +00:20:03,170 --> 00:20:06,150 +مالحقش يقوم بالوظيفة تبعته كان صير له license + +297 +00:20:06,150 --> 00:20:10,250 +فبالتالي هذه الحالة أو هذه هتعمل عندنا طبعا + +298 +00:20:10,250 --> 00:20:13,150 +coagulation cascade هنا بقولك سواء intrinsic أو + +299 +00:20:13,150 --> 00:20:19,330 +extrinsic pathway هينشطولي ال common pathway نيجي + +300 +00:20:19,330 --> 00:20:23,350 +لل intrinsic pathway ال intrinsic pathwayزي ما + +301 +00:20:23,350 --> 00:20:27,410 +حكينا هو بيبدأ بالـActivation لـFactor 12 عن طريق + +302 +00:20:27,410 --> 00:20:30,930 +الـContact Factors الـContact Factors قد تكون + +303 +00:20:30,930 --> 00:20:33,730 +Negative لتشارج Phospholipid Surfaces زي الموجودة + +304 +00:20:33,730 --> 00:20:36,990 +في الـSubendothelial tissue اللي بتظهر في حالة + +305 +00:20:36,990 --> 00:20:41,150 +حدوث جروح في خارج الجسم ممكن تكون Glass أو Kowleen + +306 +00:20:41,150 --> 00:20:45,270 +أو أشياء تانية بتعطيني Negative Charge الـFactors + +307 +00:20:45,270 --> 00:20:50,140 +اللي بتتم تقييمها في هذا الـPathwayفاكتور 12، + +308 +00:20:50,140 --> 00:20:54,000 +فاكتور 11، فاكتور 9، فاكتور 8، precalcarin، high + +309 +00:20:54,000 --> 00:20:58,340 +molecular weight منقص الـ activity للـ intrinsic + +310 +00:20:58,340 --> 00:21:04,180 +هو ال pathway عن طريق الـ BTT هلقيت خلّيني أشوف + +311 +00:21:04,180 --> 00:21:09,380 +كيف الـ BTT نيجي للـ BTT قبل ما نحكي عن الـ BTT + +312 +00:21:09,380 --> 00:21:12,900 +بدنا نتذكر مع بعض العينة اللي كنا نسحبها كيف كنا + +313 +00:21:12,900 --> 00:21:16,920 +نسحبها و كيف كنا نتعامل معاها بشكل سريعفي فحوصات + +314 +00:21:16,920 --> 00:21:20,080 +الـ Hemostasis كنا نسحب عينة البلد في Sodium + +315 +00:21:20,080 --> 00:21:23,760 +Citrate كنا نستخدم الـ Anticoagulant اللي هو + +316 +00:21:23,760 --> 00:21:26,460 +Sodium Citrate Sodium Citrate هيعمل Capture + +317 +00:21:26,460 --> 00:21:30,480 +للكالسيوم فبالتالي هيمنع عملية الـ Coagulation + +318 +00:21:30,480 --> 00:21:35,240 +هلقيت العينة برضه إيش كنا نعمل فيها؟ كنا نعملها + +319 +00:21:35,240 --> 00:21:38,800 +centrifuge وقت طويل و نفصلها مرتين عسى إنه نتخلص + +320 +00:21:38,800 --> 00:21:42,600 +من الـ Platelet اللي فيها كنا نحصل على Platelet + +321 +00:21:42,600 --> 00:21:47,310 +Por Plasmaبمعنى إن عينة الـ Plasma اللي عندي لا + +322 +00:21:47,310 --> 00:21:51,550 +تحتوي على كالسيوم ولا تحتوي على بلاتلوس فوسفوليبيد + +323 +00:21:51,550 --> 00:21:55,290 +واتنين عاملين مهمين جداً في عملية الـ Coagulation + +324 +00:21:55,290 --> 00:21:58,150 +عشان هيك لو أنا بدي أعمل initiation للـ + +325 +00:21:58,150 --> 00:22:01,650 +Coagulation لازم أضيف الكالسيوم و لازم أضيف + +326 +00:22:01,650 --> 00:22:04,950 +الفوسفوليبيد فبالتالي أنا عشان أضمن أن الـ + +327 +00:22:04,950 --> 00:22:09,130 +Intrinsic pathway هو اللي بدي يبدأ عندى بشغل + +328 +00:22:09,130 --> 00:22:14,170 +الاتفاعل كالتالي بضيف عليهcontact activator + +329 +00:22:14,170 --> 00:22:18,870 +وphospholipid تمام بعد هيك بضيف ال calcium ال + +330 +00:22:18,870 --> 00:22:21,850 +calcium يعتبر ك initiator اللي هو اللي بدي أبدأ + +331 +00:22:21,850 --> 00:22:24,730 +عندي ال reaction لما بضيف ال calcium ببدأ أحسب أو + +332 +00:22:24,730 --> 00:22:29,210 +بشغل stopwatch و ببدأ أحسب قداش الوقت اللازم لتكون + +333 +00:22:29,210 --> 00:22:33,890 +ال fiber in equilibrium طبعا هذا الفحص لأنه احنا + +334 +00:22:33,890 --> 00:22:37,650 +شغلنا ال intrinsic pathway هيشيك على أي خلل في ال + +335 +00:22:37,650 --> 00:22:42,440 +intrinsic and common pathwayهندي ملاحظة هنا إنه في + +336 +00:22:42,440 --> 00:22:44,620 +عندي بعض الـ «دراجز» زي الـ «هيبارين» والـ + +337 +00:22:44,620 --> 00:22:47,620 +«وافارين» في عندي الـ «فاكتر إنهيبتر» اللي هو بس + +338 +00:22:47,620 --> 00:22:53,120 +Anticoagulant عادة تعمل prolongation للـ BTT طيب + +339 +00:22:53,120 --> 00:22:56,440 +نيجي للـ Intrinsic Pathway اللي هو الـ Tissue + +340 +00:22:56,440 --> 00:23:00,880 +Factor Pathway عادة هذا لما بيصير جروح بطلع الـ + +341 +00:23:00,880 --> 00:23:06,360 +Tissue Factor الـ Tissue Factor هيعمل activation + +342 +00:23:06,360 --> 00:23:08,980 +لـ «فاكتر 7» هيرتبط مع «فاكتر 7» الـ Active + +343 +00:23:09,300 --> 00:23:12,720 +وبالتالي يعمل activation لـ Factor 10 ويبدأ عندي + +344 +00:23:12,720 --> 00:23:16,720 +بعدها الـ Common Pathway بتم تقييم الـ Extrinsic + +345 +00:23:16,720 --> 00:23:23,580 +Pathway عن طريق فحص الـ BT فحص + +346 +00:23:23,580 --> 00:23:28,520 +الـ BT أنا بدي أشغل فيه الـ Extrinsic Pathway مش + +347 +00:23:28,520 --> 00:23:32,820 +الـ Intrinsic Pathway فبجيب مادة زي الـ tissue + +348 +00:23:32,820 --> 00:23:36,620 +factor اللي هي طبعا هي tissue factor لكنممكن يكون + +349 +00:23:36,620 --> 00:23:40,120 +لها أكتر من مصدر مش شرط تكون من الـ Human يعني وإن + +350 +00:23:40,120 --> 00:23:44,220 +كان الأفضل اللي هو الـ Human tissue factor بجيب + +351 +00:23:44,220 --> 00:23:46,900 +الـ Thromboplastin اللي هو الـ tissue factor بضيفه + +352 +00:23:46,900 --> 00:23:49,840 +على العينة مع الكالسيوم فهيبدأ ال pathway هنا + +353 +00:23:49,840 --> 00:23:53,120 +هيبدأ ال Extrinsic pathway ليش؟ لأني أنا حطيتله ال + +354 +00:23:53,120 --> 00:23:58,060 +tissue factor طبعاً بعمل initiation و بشوف الوقت + +355 +00:23:58,060 --> 00:24:03,720 +اللازم لتكونهنا هيشيك عندي على الـ Extrinsic + +356 +00:24:03,720 --> 00:24:08,820 +Factors والـ Common Pathway Factors اللي هو الـ BT + +357 +00:24:08,820 --> 00:24:12,400 +الـ + +358 +00:24:12,400 --> 00:24:15,340 +Common Pathway الـ Common Pathway هتشتغل فيه + +359 +00:24:15,340 --> 00:24:19,580 +فاكتور 5، فاكتور 10، فاكتور 13، فاكتور 2 زي ما + +360 +00:24:19,580 --> 00:24:22,800 +أنتوا شايفين في عندي التنازق Complex هيعمل + +361 +00:24:22,800 --> 00:24:26,600 +Activation هذا جاي من الـ Intrinsic Pathway هيعمل + +362 +00:24:26,600 --> 00:24:31,050 +Activation لهفاكتور عشرة وبعدين بيجي البروثروم + +363 +00:24:31,050 --> 00:24:34,550 +بنيز Complex وبيكمل عندى لغاية ما يتكون عندى الـ + +364 +00:24:34,550 --> 00:24:38,590 +Fibrin Polymer اتوقع ان الـ BT أو الـ BTT بكشف + +365 +00:24:38,590 --> 00:24:41,710 +عندى اذا كان فيه خلل في الـ Common Pathway وعادة + +366 +00:24:41,710 --> 00:24:44,330 +اذا كان فيه خلل في الـ Factors بتاعت ال Common + +367 +00:24:44,330 --> 00:24:52,190 +Pathway هيتأثر التانين هيتأثر عندى الـ BT و الـ + +368 +00:24:52,190 --> 00:24:52,470 +BTT + +369 +00:24:55,680 --> 00:24:59,040 +طبعاً هندي هذا الـ Cascade ملخص بيوضح فيه الـ + +370 +00:24:59,040 --> 00:25:01,720 +Intrinsic و الـ Extrinsic pathway و الـ Common + +371 +00:25:01,720 --> 00:25:08,340 +pathway طيب هلقات احنا حكينا عن الـ Coagulation + +372 +00:25:08,340 --> 00:25:12,840 +cascade زي ما في عندي Coagulation cascade في عندي + +373 +00:25:12,840 --> 00:25:16,520 +Anti-coagulant pathway هلقات عملية الـ Coagulation + +374 +00:25:16,520 --> 00:25:21,820 +مش لازم تضل شغالة على طول لازم تيجي أشياء توقف + +375 +00:25:21,820 --> 00:25:25,190 +عملية الـ Coagulationففي عندي أكتر من pathway في + +376 +00:25:25,190 --> 00:25:30,490 +عندي الـ antithrombine pathway في عندي protein C + +377 +00:25:30,490 --> 00:25:33,250 +-thrombomodulin pathway في عندي tissue factor + +378 +00:25:33,250 --> 00:25:37,090 +مثلما أنتوا شايفين في عندي أكتر من anticoagulant + +379 +00:25:37,090 --> 00:25:41,850 +pathway في عندي ال tissue factor pathway inhibitor + +380 +00:25:41,850 --> 00:25:45,050 +في عندي ال antithrombin 3 + +381 +00:25:47,610 --> 00:25:51,650 +طيب نيجي لأول pathway اللي هي في الـ Anti + +382 +00:25:51,650 --> 00:25:54,410 +-coagulation اللي هي الـ Anti-thrombin pathway + +383 +00:25:54,410 --> 00:25:59,090 +Anti-thrombin يعتبر أهم inhibitor لـ coagulation + +384 +00:25:59,090 --> 00:26:05,130 +للثرمبين بيشكل حوالي 80% of ثرمبين inhibitory + +385 +00:26:05,130 --> 00:26:10,190 +activity in plasma يعني هو أهم pathway عندنا الـ + +386 +00:26:10,190 --> 00:26:13,790 +Anti-thrombin عادة بيعمل inhibition directly + +387 +00:26:14,470 --> 00:26:18,810 +للثرمبين ولفاكتور عشرة بالإضافة فاكتور عشرة active + +388 +00:26:18,810 --> 00:26:22,490 +طبعا هو لما يعمل inhibition للثرمبين ولفاكتور عشرة + +389 +00:26:22,490 --> 00:26:25,750 +أكيد هيتوقف ال pathway لأن هذه ال factors المفروضة + +390 +00:26:25,750 --> 00:26:30,010 +تقوم بدورها لكن هو طالما عمللها block مش هيتكمل ال + +391 +00:26:30,010 --> 00:26:33,230 +pathway وبالتالي مش هيتكون الفيبرين وهكذا هو يقوم + +392 +00:26:33,230 --> 00:26:39,650 +بدوره ك anticoagulant طيب نشوف تفاصيل أكتر عن + +393 +00:26:39,650 --> 00:26:45,550 +الموضوع ال antithrombinبعمل inhibition زي ما قلنا + +394 +00:26:45,550 --> 00:26:49,950 +بشكل مباشر أو بشكل أساسي للاثرنبين ولا factor 10 + +395 +00:26:49,950 --> 00:26:52,830 +active بالإضافة لأنه بعمل inhibition ل other + +396 +00:26:52,830 --> 00:26:58,050 +factors زي factor 9 active، factor 11، factor 12 + +397 +00:26:58,050 --> 00:27:03,430 +active بعمل inhibition لل complement enzyme C1 كيف + +398 +00:27:03,430 --> 00:27:07,530 +بتصير عملية ال inhibition لما بيصير جروح بتطلع + +399 +00:27:07,530 --> 00:27:11,150 +مادة الهيبرانسلفات هذه المادة بتطلع من ال + +400 +00:27:11,150 --> 00:27:15,970 +endothelial cellsمادة شبيهة بالـ Heparin هذه + +401 +00:27:15,970 --> 00:27:22,210 +المادة راح تروح و هي مرتبطة بالـ Antithrombin لما + +402 +00:27:22,210 --> 00:27:26,950 +بترتبط فيه بتعمل له conformational changes بتغير + +403 +00:27:26,950 --> 00:27:31,970 +الشكل أو التركيبة بتاعته بحيث أنه يصير سهل عليه + +404 +00:27:31,970 --> 00:27:36,550 +أنه يرتبط بالإنزيم أو بالإنزايم و يعمله + +405 +00:27:36,550 --> 00:27:40,880 +inactivationThis facilitated its reaction with the + +406 +00:27:40,880 --> 00:27:43,560 +enzyme أنتثرومبين form a complex with the + +407 +00:27:43,560 --> 00:27:47,200 +inhibited proteins بعد هي ارتبط مع الانزيم اللي + +408 +00:27:47,200 --> 00:27:52,560 +صارله هنا هذه ميكانيزم بسيطة ورسم تخطيتي بسيط جدا + +409 +00:27:52,560 --> 00:27:57,320 +بيوضح عندي كيف ارتباط الانتثرومبين مع الهيبرين أو + +410 +00:27:57,320 --> 00:28:01,000 +مع الهيبرانسالفات بيغير ال confirmation لإله بيصير + +411 +00:28:01,000 --> 00:28:04,940 +موائم لارتباط بال active factors خلّيني أشوف هلأ + +412 +00:28:04,940 --> 00:28:10,680 +هاي عندنا الهيبرينفي عندى الـ Antithrombin ارتباط + +413 +00:28:10,680 --> 00:28:13,920 +الهيبرين مع الـ Antithrombin هيغير شكل الـ + +414 +00:28:13,920 --> 00:28:19,040 +Antithrombin شفتين كيف صار شكله؟ فهذا الشكل هيصير + +415 +00:28:19,040 --> 00:28:23,640 +موائم لشكل factor 10 active و factor 2 active اللي + +416 +00:28:23,640 --> 00:28:26,860 +هو الـ Thrombin وبالتالي هيصير ارتباط بينهم و + +417 +00:28:26,860 --> 00:28:30,640 +هيصير هذا ال factor اللي كان active هيصير inactive + +418 +00:28:32,100 --> 00:28:35,440 +الرسمة اللي معكم هيها الرسمة اللي معكم في الملزمة + +419 +00:28:35,440 --> 00:28:39,100 +خلينا نشوف إيش فيها في عندي الـ Antithrombine + +420 +00:28:39,100 --> 00:28:41,920 +والهيبرين لما يرتبط الـ Antithrombine بالهيبرين + +421 +00:28:41,920 --> 00:28:46,920 +بصير موائم لارتباط للثرمبين بعد هيك بنفك الهيبرين + +422 +00:28:46,920 --> 00:28:53,560 +فبالتالي هيتكون عندي Complex من ال factor اللي صار + +423 +00:28:53,560 --> 00:28:59,310 +inactive مع الـ Antithrombine وهيك بنكوننيجي للـ + +424 +00:28:59,310 --> 00:29:03,030 +pathway التاني اللي هو protein C pathway خلّوا + +425 +00:29:03,030 --> 00:29:06,530 +بالكم إحنا بنحكي عن anticoagulant pathway يعني + +426 +00:29:06,530 --> 00:29:10,810 +هيمشي الكسكيت ويكون عندي الـ coagulation factors + +427 +00:29:10,810 --> 00:29:14,770 +الـ active وحتى تبدأ تتكون الفيبرين هلأ في مرحلة + +428 +00:29:14,770 --> 00:29:17,910 +معينة لازم الكسكيت هذا يبدأ يشتغلله الـ + +429 +00:29:17,910 --> 00:29:22,390 +anticoagulant عشان يوقف الـ coagulation أو يقلل من + +430 +00:29:22,390 --> 00:29:26,670 +الـ coagulation إيش اللي بصير؟ لما بزيد في ثرمبين + +431 +00:29:27,500 --> 00:29:31,220 +نتيجة الـ activation لـ Coagulation cascade + +432 +00:29:31,220 --> 00:29:35,720 +الثرمبين هذا هيروح يرتبط مع الـ Thrombomodulin + +433 +00:29:35,720 --> 00:29:41,240 +ثرمبوموديولين هذا موجود على الـ Endothelium هيكون + +434 +00:29:41,240 --> 00:29:46,980 +ثرمبين ثرمبوموديولين Complex هذا الـ Complex هيعمل + +435 +00:29:46,980 --> 00:29:52,820 +activation لبروتين C البروتين C هيصير Active + +436 +00:29:52,820 --> 00:29:57,390 +بروتين C فلقيت لما بيصير activation لبروتين Cهيروح + +437 +00:29:57,390 --> 00:30:00,190 +الـ «بروتين C» يرتبط مع «cofactor» اللي هو «بروتين + +438 +00:30:00,190 --> 00:30:05,150 +S» ومع «factor V» inactive فلقيت ال «complex» اللي + +439 +00:30:05,150 --> 00:30:08,590 +اتوان عندي أكتر «بروتين C» و«بروتين S» و«factor V» + +440 +00:30:08,590 --> 00:30:11,910 +inactive هيعملوا «inactivation» لـ «factor VIII» + +441 +00:30:11,910 --> 00:30:17,570 +و«inactivation» لـ «factor V» وهيك هيوقفوا تكون + +442 +00:30:17,570 --> 00:30:22,660 +الـ «Thrombin»تمام؟ لأنه زي ما انتوا عارفين فاكتور + +443 +00:30:22,660 --> 00:30:27,760 +5 هو جزء أساسي في الـ Thrombinase Complex و فاكتور + +444 +00:30:27,760 --> 00:30:31,360 +8 جزء أساسي في التمنازل Complex فطالما صار ان + +445 +00:30:31,360 --> 00:30:36,280 +اكتشف هذه زي ما انتوا شايفين الاثرومبين اتكون + +446 +00:30:36,280 --> 00:30:41,700 +نتيجة طبعا بدت تتكون ال clot ومش الكسكاد وزاد + +447 +00:30:41,700 --> 00:30:45,380 +الاثرومبين في ال blood زيادة الاثرومبين حيرضت مع + +448 +00:30:45,380 --> 00:30:49,400 +الاثرومبوموديولينهيعمل أثرومبين أثرومبوموديولين + +449 +00:30:49,400 --> 00:30:53,440 +Complex هدول إيش راح يعملوا؟ راح يعملوا activation + +450 +00:30:53,440 --> 00:31:01,260 +لبروتين C هيتكون عندى active بروتين C طبعا اتكونت + +451 +00:31:01,260 --> 00:31:04,880 +الأثرومبس عليها factor 5 active و عليها factor 8 + +452 +00:31:04,880 --> 00:31:13,640 +active هيجي بروتين C ال active طبعا بمساعدة بروتين + +453 +00:31:13,640 --> 00:31:19,820 +Sهيعملوا الـ Factor 8 Active هيتحول لـ Factor 8 + +454 +00:31:19,820 --> 00:31:26,780 +Inactive برضه هنا هيصير عندى بمساعدة Factor 5 + +455 +00:31:26,780 --> 00:31:29,860 +هيصير Inactivation لـ Factor 5 فبالتالي هيتوقف + +456 +00:31:29,860 --> 00:31:33,320 +Factor 5 و Factor 8 الـ Active هيصير لهم + +457 +00:31:33,320 --> 00:31:37,680 +Inactivation و هيتوقف الـ Cascade هنا بيحكي لنا + +458 +00:31:37,680 --> 00:31:42,890 +أنه فين أشياء بتعتبر كـ Co-factors لـ Protein Sلـ + +459 +00:31:42,890 --> 00:31:46,550 +Protein C عفواً اللي هي Protein S و Factor 5 الـ + +460 +00:31:46,550 --> 00:31:49,690 +Protein S بيساعد الـ Active Protein C على إنه + +461 +00:31:49,690 --> 00:31:52,190 +يرتبط مع الـ Phospholipids بتاعة الـ Platelets و + +462 +00:31:52,190 --> 00:31:55,810 +الـ Endothelium الـ Protein S اللي بيشتغل لازم + +463 +00:31:55,810 --> 00:32:00,790 +يكون Free لكن قريب من 60% من الـ Protein S بنلاقي + +464 +00:32:00,790 --> 00:32:07,430 +مرتبط بـ C4B Binding Protein Factor 5 مع Protein S + +465 +00:32:07,430 --> 00:32:12,870 +طبعاً زي ما قلنا بيخلوا الـ Active Protein Cيعمل + +466 +00:32:12,870 --> 00:32:18,410 +degradation لـ factor 8 و factor 9 نيجي للميكانيزم + +467 +00:32:18,410 --> 00:32:23,970 +الثالث اللي هو tissue factor pathway inhibitor هذا + +468 +00:32:23,970 --> 00:32:27,750 +بيطلع من الـ endothelium لما بيصير activation لل + +469 +00:32:27,750 --> 00:32:32,450 +pathway لل factors برتبط مع factor 10 active + +470 +00:32:32,450 --> 00:32:36,990 +بيعملوا complex factor 10 active معTissue Factor + +471 +00:32:36,990 --> 00:32:40,850 +Pathway Inhibitor ويروح ويرتبطه بتعوني الـ + +472 +00:32:40,850 --> 00:32:44,430 +Extrinsic Pathway الـ Tissue Factor مع Factor 7 + +473 +00:32:44,430 --> 00:32:48,350 +Active وبالتالي بعمل Inactivation للـ Extrinsic + +474 +00:32:48,350 --> 00:32:53,370 +Pathway طيب + +475 +00:32:53,370 --> 00:32:57,830 +نيجي للـ Fibrinolytic Pathway طبعا احنا بمجرد ما + +476 +00:32:57,830 --> 00:33:01,630 +الفيبرين يتكون هتبدأ عملية الـ Fibrinolysis لأن هو + +477 +00:33:01,630 --> 00:33:04,670 +بده يقدّي وظيفة وينتهي مش لازم يظل موجود في الجسم + +478 +00:33:05,630 --> 00:33:11,530 +طبعاً في عندى بلازمينوجين البلازمينوجين هذا هو + +479 +00:33:11,530 --> 00:33:15,310 +اللى بتتحول لبلازمين وبيعمل على تكسير الـ fibrin + +480 +00:33:15,310 --> 00:33:19,690 +اللى اتكون البلازمينوجين بده يصيرله activation إما + +481 +00:33:19,690 --> 00:33:22,610 +بيصيرله in vivo عن طريق اتمشه بلازمينوجين + +482 +00:33:22,610 --> 00:33:27,330 +activator هذا بيجي من الـ Indothelium أو عن طريق + +483 +00:33:27,330 --> 00:33:32,690 +اليوركيناز بلازمينوجين activator ممكن يكون اكسوجنس + +484 +00:33:32,880 --> 00:33:36,080 +عن طريق الـ streptokinase اللي بينعطل المرضى اللي + +485 +00:33:36,080 --> 00:33:41,940 +عندهم جلطات عشان يتدوب الجلطات كلهم بيشتغل على الـ + +486 +00:33:41,940 --> 00:33:44,540 +plasminogen بيعملوا activation بيحولوا إلى + +487 +00:33:44,540 --> 00:33:49,960 +البلازمين البلازمين هذا هيعمل degradation للفيبرين + +488 +00:33:49,960 --> 00:33:54,280 +وعلى الفيبرينوجين لو شغل على الفيبرينوجين هيعطيني + +489 +00:33:54,280 --> 00:33:57,740 +D-dimer لكن لو شغل على الفيبرينوجين مش هيعطي D + +490 +00:33:57,740 --> 00:34:01,480 +-dimer علشان هيك الـD-dimer ارتفاع ودليل على انه + +491 +00:34:01,480 --> 00:34:06,720 +فيهطلعوا معايا Degradation of fibrin and + +492 +00:34:06,720 --> 00:34:09,700 +fibrinogen «فيبرين» or «فيبرين» «فيبرينوجين» or + +493 +00:34:09,700 --> 00:34:10,780 +«فيبرين» «فيبرين» or «فيبرين» «فيبرينوجين» or + +494 +00:34:10,780 --> 00:34:14,280 +«فيبرين» «فيبرينوجين» or «فيبرين» «فيبرينوجين» + +495 +00:34:14,280 --> 00:34:14,980 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +496 +00:34:14,980 --> 00:34:15,040 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +497 +00:34:15,040 --> 00:34:15,820 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +498 +00:34:15,820 --> 00:34:18,080 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» + +499 +00:34:18,080 --> 00:34:25,460 +«فيبرينوجين» «فيبرينوجين» «فيبرينوجين» «فيبرينوج + +500 +00:34:31,020 --> 00:34:33,780 +لغاية ما في النهاية يصير complete degradation + +501 +00:34:33,780 --> 00:34:38,980 +لإلهم الآن كيف بدنا نعمل evaluation لـFibrinolysis + +502 +00:34:38,980 --> 00:34:44,300 +إذا كان فعلا صار فيه اتكوّن fibriniclot وصار لها + +503 +00:34:44,300 --> 00:34:48,700 +degradation هنلاقي الـD-dimer ارتفع في blood إذا + +504 +00:34:48,700 --> 00:34:51,160 +وجود الـD-dimer قد يعطي + +505 +00:35:00,380 --> 00:35:04,640 +الـ Pulmonary embolism الـ DIC في حالات الـ Normal + +506 +00:35:04,640 --> 00:35:07,160 +الـ Pregnancy و لو صار فيه Complication في ال + +507 +00:35:07,160 --> 00:35:10,280 +pregnancy هتلاقي ال level تاعه ارتفع بشكل كبير و + +508 +00:35:10,280 --> 00:35:10,780 +ملحوظ + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/re26D5Gw16M.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/re26D5Gw16M.srt new file mode 100644 index 0000000000000000000000000000000000000000..b957df75204082edd45f8dd51928c5e2d17d2816 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/re26D5Gw16M.srt @@ -0,0 +1,2035 @@ +1 +00:00:01,690 --> 00:00:06,950 +اعوذ بالله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى هذا الفصل في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في الـ outlines حكينا إنه هذا المساق بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتم عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبا بتنقسم لـ three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +الثلاثة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش إني أحفظ إيش تعريف الأنيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش الـ pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط هذه النتائج مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مصاحبة لهذا الـ result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات عشان أتأكد من الـ results معينة هذا + +20 +00:01:32,370 --> 00:01:36,270 +الكلام بإذن الله كله راح نناقشه مع بعض شوية شوية + +21 +00:01:36,270 --> 00:01:40,390 +أول حاجة هنشرحها بعد هيك هناخد عليها أمثلة تبقى على + +22 +00:01:40,390 --> 00:01:43,470 +شكل حالات مرضية طبعا محاضرتنا هيكون فيها مجموعة من + +23 +00:01:43,470 --> 00:01:48,410 +الأهداف في النهاية راح يكون عندنا القدرة على إنه + +24 +00:01:48,410 --> 00:01:51,950 +نعرف الأنيميا راح نلاقي الأنيميا إلها أكتر من + +25 +00:01:51,950 --> 00:01:56,960 +تعريف ما شاء الله رب العالمين هنشوف مع بعض إيش هي + +26 +00:01:56,960 --> 00:02:00,820 +التعريفات الصحيحة وفي ناس يعني في تعريفات اللي لها + +27 +00:02:00,820 --> 00:02:04,680 +علاقة بالمختبر وفي تعريفات اللي لها علاقة بالأطباء + +28 +00:02:04,680 --> 00:02:09,080 +فهنشوف التعريفات المختلفة اللي لها راح يكون عندنا + +29 +00:02:09,080 --> 00:02:16,720 +القدرة على مناقشة أسباب الأنيميا الـ clinical + +30 +00:02:16,720 --> 00:02:19,940 +significance لـ categories المختلفة برضه من + +31 +00:02:19,940 --> 00:02:24,740 +الأنيميا راح نعرف نصنف أنواع الأنيميا المختلفة + +32 +00:02:25,610 --> 00:02:30,490 +نقدر في النهاية نقول هذه مثلا microcytic anemia + +33 +00:02:30,490 --> 00:02:33,870 +هذه macrocytic anemia هذه normocytic مثلا + +34 +00:02:33,870 --> 00:02:39,310 +normochromic anemia فنقدر نصنف الأنيميا حسب قراءة + +35 +00:02:39,310 --> 00:02:44,910 +النتائج لأحد الأنواع الرئيسية فيها يكون عندنا + +36 +00:02:44,910 --> 00:02:50,350 +القدرة على أننا نناقش نتائج النتائج اللي بيحصل + +37 +00:02:50,350 --> 00:02:58,000 +عليها في المختبر وأقدر أنسب هذه النتائج لأحد الـ + +38 +00:02:58,000 --> 00:03:01,940 +categories من الأنيميا يعني مثلا شوف الـ CBC أول + +39 +00:03:01,940 --> 00:03:04,800 +حاجة بدي أطلع مثلا على الـ Hemoglobin Hemoglobin + +40 +00:03:04,800 --> 00:03:09,160 +واطي إذا في أنيميا طيب إيش نوعها مثلا هي microcytic + +41 +00:03:09,160 --> 00:03:12,120 +hypochromic and so on وأسير أربط هذه النتائج + +42 +00:03:12,120 --> 00:03:15,530 +ببعضها perform basic laboratory test for the + +43 +00:03:15,530 --> 00:03:20,190 +diagnosis of anemia كيف؟ طبعا هذه الشخصية هذه + +44 +00:03:20,190 --> 00:03:22,830 +الـ basic laboratory test for diagnosis of anemia + +45 +00:03:22,830 --> 00:03:25,990 +طبعا هذه احنا شرحناها بالتفصيل في مساق الدم + +46 +00:03:25,990 --> 00:03:28,390 +السريري اللي هي الفحوصات الأساسية اللي لازم تشترك في + +47 +00:03:28,390 --> 00:03:30,810 +الأنيميا الـ outlines هيكون بداية عندنا definition + +48 +00:03:30,810 --> 00:03:37,730 +of anemia classification of anemia برضه يعني هيكون + +49 +00:03:37,730 --> 00:03:41,790 +عندنا بعض النقاط هناخدها الـ hematologic response + +50 +00:03:41,790 --> 00:03:46,750 +to anemia Signs of Accelerated Bone Erythropoiesis + +51 +00:03:46,750 --> 00:03:50,730 +إيش بيصير لما الـ bone marrow يصير يشغل تحت stress + +52 +00:03:50,730 --> 00:03:54,510 +Physiologic Response to Anemia Methods of + +53 +00:03:54,510 --> 00:03:59,570 +Classification Anemia Diagnosis and Causes أسبابها + +54 +00:03:59,570 --> 00:04:03,970 +وتشخيصها Lab Investigation of Anemia كيف إحنا نشخص + +55 +00:04:03,970 --> 00:04:08,650 +الأنيميا في المختبر؟ هيكون عندنا طبعا أنواع + +56 +00:04:08,650 --> 00:04:14,240 +الأنيميا Microcytic Hypochromic نورموسيتك مثلا + +57 +00:04:14,240 --> 00:04:17,800 +نورموسيتك أنيميا نورموسيتك أنيميا due to + +58 +00:04:17,800 --> 00:04:20,760 +hemoglobin and pathase طبعا كل هذه أشياء راح + +59 +00:04:20,760 --> 00:04:27,100 +ناخدها بإذن الله بالتفصيل طيب + +60 +00:04:27,100 --> 00:04:31,420 +نحاول نعرف الأنيميا مع بعض لو جيت قلت لكم عرفوا لي + +61 +00:04:31,420 --> 00:04:37,600 +الأنيميا أكيد هتقولوا لي نقص الـ RBCs نقص الـ hemoglobin + +62 +00:04:37,600 --> 00:04:42,740 +نقص الـ hematocrit يعني هي نقص الـ Oxygen-carrying + +63 +00:04:42,740 --> 00:04:47,700 +components of blood بالظبط نقص الـ Oxygen-carrying + +64 +00:04:47,700 --> 00:04:51,140 +components مين هي أهم حاجة بيحمل الأكسجين؟ طبعا + +65 +00:04:51,140 --> 00:04:54,080 +زي ما أنتم عارفين الـ Hemoglobin فبالتالي + +66 +00:04:54,080 --> 00:04:58,120 +الأنيميا is a decrease in the RBCs count + +67 +00:04:58,120 --> 00:05:02,680 +Hemoglobin or Hematocrit طبعا لو أنا قارنتهم بالـ + +68 +00:05:02,680 --> 00:05:06,200 +Normal Range وأنتم عارفين إن احنا لما بنقارن بـ + +69 +00:05:06,200 --> 00:05:11,680 +Range كل فئة عمرية لها range وبرضه related to sex + +70 +00:05:11,680 --> 00:05:15,680 +الذكر يختلف عن الأنثى فبالتالي لما أنا بدي أقارن + +71 +00:05:15,680 --> 00:05:22,720 +أقارن بالـ range المخصص لهذه الفئة العمرية وهذا الـ + +72 +00:05:22,720 --> 00:05:28,440 +gender طيب نيجي لتعريف + +73 +00:05:28,440 --> 00:05:32,420 +أو تفريق ما بين شغلتين true anemia and pseudo + +74 +00:05:32,420 --> 00:05:37,830 +anemia لـ true anemia بتبقى عندي الـ blood + +75 +00:05:37,830 --> 00:05:44,670 +components قليلة تمام والـ plasma volume normal + +76 +00:05:44,670 --> 00:05:51,310 +decreased RBCs mass and normal plasma volume كويس؟ + +77 +00:05:51,310 --> 00:05:55,870 +يعني مين اللي بنقص عندي؟ الـ RBCs السودوانيميا + +78 +00:05:55,870 --> 00:06:00,890 +السودوانيميا مختلفة فإن كمية الـ RBCs ما بتكونش + +79 +00:06:00,890 --> 00:06:06,550 +قليلة لكن بيصير لها dilution يعني بيصير تخفيف للدم + +80 +00:06:06,550 --> 00:06:12,270 +فبالتالي نظرا لأن الدم اتخفف زادت كمية الـ + +81 +00:06:12,270 --> 00:06:16,730 +fluids اللي فيه كل ما أقيس حاجة أو أقرأها هلاقي + +82 +00:06:16,730 --> 00:06:20,670 +تركيزها قليل لأنه صار لها فعليا dilution بس هي ما + +83 +00:06:20,670 --> 00:06:25,290 +ناقص تصنيعها هي المشكلة إنه حصل dilution وهذه حاجة + +84 +00:06:25,290 --> 00:06:29,310 +عادة بتكون مؤقتة بنسميها pseudoanemia أو + +85 +00:06:29,310 --> 00:06:33,990 +dilutional anemia normal RBCs mass and increase + +86 +00:06:33,990 --> 00:06:38,750 +plasma volume طبعا هذه ممكن تصير في حالات الـ + +87 +00:06:38,750 --> 00:06:43,990 +pregnancy أو في حالات الـ volume overload الناس + +88 +00:06:43,990 --> 00:06:47,970 +اللي بتاخد intravenous fluid محلول وريدي وبتكون + +89 +00:06:47,970 --> 00:06:51,210 +كميته كتير كبيرة ممكن يعمل dilution للدم في + +90 +00:06:51,210 --> 00:06:54,330 +حالات الـ congestive heart failure يعني عضلة القلب + +91 +00:06:54,330 --> 00:06:59,280 +مش قادرة تستوعب الدم اللي جايها عشان تعمله بنقله + +92 +00:06:59,280 --> 00:07:03,960 +للرئتين ويصير له أكسجر فبيصير تجمع لاستوائل فيه خاصة + +93 +00:07:03,960 --> 00:07:07,740 +الجزء اليمين من الجسم وبالتالي بيصير dilution + +94 +00:07:07,740 --> 00:07:13,920 +للدم طيب هذه عادة بلاقي الـ hemoglobin والـ + +95 +00:07:13,920 --> 00:07:18,080 +hematocrit فيها low ليش؟ لأنه صار في dilution مش + +96 +00:07:18,080 --> 00:07:21,180 +لأنه صار نقص في تصنيع الـ RBC أو خلل في تصنيع الـ + +97 +00:07:21,180 --> 00:07:25,740 +hemoglobin أو الـ RBC لأ هنا دراسة طبيعية تظهر عندي + +98 +00:07:25,740 --> 00:07:30,920 +الفرق ما بين الـ normal anemia والـ Normal عفوا + +99 +00:07:30,920 --> 00:07:35,560 +والـ True Anemia والـ Pseudo Anemia لو تخيلنا عينة + +100 +00:07:35,560 --> 00:07:40,400 +الـ blood بهذا الشكل Hemoglobin فيها 15 الـ + +101 +00:07:40,400 --> 00:07:44,980 +hematocrit 45% عند الـ Normal احنا عارفين 45% + +102 +00:07:44,980 --> 00:07:47,220 +hematocrit طبعا زي ما احنا عارفين إن الـ + +103 +00:07:47,220 --> 00:07:53,960 +hematocrit بيمثل نسبة الـ RBC في العينة يعني 45% من + +104 +00:07:53,960 --> 00:07:59,520 +الـ sample كلها هتكون hematocrit هتكون RBC تمام؟ هذول + +105 +00:07:59,520 --> 00:08:04,060 +الوضع الطبيعي هلأ في الـ True Anemia هتلاقي إنه + +106 +00:08:04,060 --> 00:08:09,320 +الـ hematocrit قل يعني الـ RBCs نفسها قلت في حين + +107 +00:08:09,320 --> 00:08:13,200 +إنه الـ plasma volume طبيعي يعني لو أجيني أقارنها + +108 +00:08:13,200 --> 00:08:15,820 +الـ plasma volume هذا بالـ normal plasma volume + +109 +00:08:15,820 --> 00:08:20,300 +هنلاقيهم زي بعض بس مين اللي نقص؟ نقص الـ RBCs + +110 +00:08:20,300 --> 00:08:25,380 +mass فعليا هنا هتلاقي الـ hematocrit مثلا 30% + +111 +00:08:25,380 --> 00:08:30,660 +والـ hemoglobin 10 هذه حالة أنيميا حقيقية ليش؟ لأن + +112 +00:08:30,660 --> 00:08:35,000 +البلازما حجمها ما تأثر مقارنة بالنورمال بينما + +113 +00:08:35,000 --> 00:08:39,780 +كمية الـ RBCs هي اللي نقصت لو أجينا نشوف + +114 +00:08:39,780 --> 00:08:43,480 +السودوانيميا هنلاقي كمية الـ RBCs زيها زي النورمال + +115 +00:08:43,480 --> 00:08:48,280 +لكن كمية البلازما زادت فصار dilution لكل الـ + +116 +00:08:48,280 --> 00:08:52,820 +parameters هنلاقي الـ hematocrit صار 30% زي وزي الـ + +117 +00:08:52,820 --> 00:08:58,340 +true anemia لكن هو فعليا كمية الـ RBCs حقيقية زي ما + +118 +00:08:58,340 --> 00:09:01,600 +هي Normal والتصنيعها Normal بس المشكلة إنه صار + +119 +00:09:01,600 --> 00:09:06,820 +Hemodilution بسبب زيادة حجم البلازما وهنا شايفين + +120 +00:09:06,820 --> 00:09:11,260 +طبعا التمثيل للـ 3 حالات للـ Normal و للـ True + +121 +00:09:11,260 --> 00:09:16,220 +Anemia و للـ Pseudo Anemia بشكل يعني واضح احنا + +122 +00:09:16,220 --> 00:09:23,780 +اللي بتهمنا اللي هي الـ True Anemia طيب، + +123 +00:09:23,780 --> 00:09:28,750 +في عندنا ملاحظة مهمة جدا يعني يا بنات ممكن بنتين + +124 +00:09:28,750 --> 00:09:35,810 +فيكم يعملوا CBC البنتين يطلعوا لي يطلع دمهم مثلا 11 + +125 +00:09:35,810 --> 00:09:39,590 +gram per deciliter الهيموجلوبين 11 gram per + +126 +00:09:39,590 --> 00:09:45,730 +أقول لسين أنت هيموجلوبينك كويس وأقول + +127 +00:09:45,730 --> 00:09:51,050 +لصاد أنت هيموجلوبينك مش كويس ليش؟ خلّيني أفكر + +128 +00:09:51,050 --> 00:09:54,900 +فيها، مع أن الاثنتين في نفس العمر نفس الظروف + +129 +00:09:54,900 --> 00:09:58,880 +تقريباً وفي نفس البيئة عايشين و ليش أنا اعتبرت هذي + +130 +00:09:58,880 --> 00:10:03,140 +Normal وهذي Abnormal فنسين قلتلها ان أنت كويسة + +131 +00:10:03,140 --> 00:10:06,920 +لأن أنا طول عمري أو أكثر من مرة أتجب لـ CBC يكون + +132 +00:10:06,920 --> 00:10:12,260 +هذا هو الـ range الطبيعي لها يعني 11، 11.5، 10.5 هي + +133 +00:10:12,260 --> 00:10:15,800 +دمها هيك أيش ما تعمل مش هيزيد عن هيك لكن الثانية + +134 +00:10:15,800 --> 00:10:19,580 +كان دمها 13 أنا عارفة أن قبل هيك عملت الـ + +135 +00:10:19,580 --> 00:10:24,470 +hemoglobin كان 13 وأجتني اليوم بـ 11 بقولها لأ أنت + +136 +00:10:24,470 --> 00:10:28,950 +hemoglobinك نازل إذا ضروري عشان أحكم على إنسان أنه + +137 +00:10:28,950 --> 00:10:32,990 +عنده anemia يكون فيه فرق بين قراءته الحالية + +138 +00:10:32,990 --> 00:10:38,970 +والقراءات اللي عادة هو بيحصل عليها لما بيعمل CBC + +139 +00:10:38,970 --> 00:10:43,170 +تمام؟ «Anemia must also relate to the level of + +140 +00:10:43,170 --> 00:10:46,750 +hemoglobin the individual normally possesses» لازم + +141 +00:10:46,750 --> 00:10:51,770 +أقارنه بالقيمة الطبيعية لهذا الشخص اللي عادة بيكون + +142 +00:10:51,770 --> 00:10:56,330 +الـ hemoglobin بهذا الشكل هنا ضرب لمثال If an + +143 +00:10:56,330 --> 00:11:00,190 +adult male usually maintains a hemoglobin level 16 + +144 +00:11:00,190 --> 00:11:04,230 +gram per deciliter هو عادة بياخد هذا الرقم 16 gram + +145 +00:11:04,230 --> 00:11:08,650 +per deciliter لكن بعد فترة لقينا أن الـ + +146 +00:11:08,650 --> 00:11:14,550 +hemoglobin صار 14 لأ هذا معنى الكلام أنه فيه مشكلة + +147 +00:11:14,550 --> 00:11:19,050 +نزلت الاثنين جرام هدول بده متابعة ونشوف إذا كان + +148 +00:11:19,050 --> 00:11:22,050 +صار خلل معين نحاول نعالجه، تمام؟ + +149 +00:11:27,500 --> 00:11:30,840 +عنا مجموعة من الحالات المرضية أنا هيك بحكي roughly + +150 +00:11:30,840 --> 00:11:36,120 +بشكل عام اللي ممكن تكون مسببات لنقص الـ hemoglobin + +151 +00:11:36,120 --> 00:11:40,860 +nutritional deficiencies يعني نقص في المواد + +152 +00:11:40,860 --> 00:11:46,980 +الغذائية قد يكون نقص في كالسيوم، في الحديد، تقم واحد + +153 +00:11:46,980 --> 00:11:51,360 +أول شيء تتذكره في الفوليك أسيد، في الفولات أو فوليك + +154 +00:11:51,360 --> 00:11:54,900 +أسيد، في vitamin B12 كلها هذه أسباب تؤدي إلى + +155 +00:11:54,900 --> 00:11:59,520 +الأنيميا إذن هذه nutritional deficiencies External + +156 +00:11:59,520 --> 00:12:04,480 +or internal blood loss فقد الدم على فترات قد يكون + +157 +00:12:04,480 --> 00:12:10,460 +فقد الدم acute ويؤدي لهبوط في الدم في الـ + +158 +00:12:10,460 --> 00:12:14,600 +hemoglobin وقد يكون chronic إن الإنسان هذا بفقد + +159 +00:12:14,600 --> 00:12:18,620 +كميات بسيطة من الدم على فترات زمنية طويلة فبالتالي + +160 +00:12:18,620 --> 00:12:24,140 +بينشأ عنها أنيميا Increased extraction of RBCs تكسير + +161 +00:12:24,140 --> 00:12:28,580 +الـ RBCs لأي سبب من الأسباب قد يكون سبب مناعي قد + +162 +00:12:28,580 --> 00:12:32,380 +يكون يعني في مسببات كثير ممكن تعمل تكسير للـ blood + +163 +00:12:32,380 --> 00:12:35,800 +راح ناخذها إن شاء الله في الـ hemolytic anemia طيب + +164 +00:12:35,800 --> 00:12:39,780 +ineffective or decreased production of RBCs يعني + +165 +00:12:39,780 --> 00:12:42,740 +فيه مشكلة في الـ production للـ RBCs الـ RBCs ما + +166 +00:12:42,740 --> 00:12:50,490 +بتنتج بشكل طبيعي نتيجة خلل معين في العناصر أو في + +167 +00:12:50,490 --> 00:12:53,810 +الأشياء اللي لازمة لتصنيعها فبالتالي ما بتتصنع + +168 +00:12:53,810 --> 00:12:58,610 +بالشكل السليم abnormal hemoglobin synthesis طبعاً + +169 +00:12:58,610 --> 00:13:02,470 +احنا عارفين أن الـ hemoglobin بتتكون من الـ 2α2β- + +170 +00:13:02,470 --> 00:13:10,030 +والهم طبعاً الـ globin اللي هو 2α2β- ممكن يصير فيه + +171 +00:13:10,030 --> 00:13:14,790 +mutations مختلفة ومتعددة الـ mutations هذه عادة + +172 +00:13:14,790 --> 00:13:21,380 +تؤدي إلى حدوث خلل في الهيموجلوبين قد يكون هذا + +173 +00:13:21,380 --> 00:13:25,040 +الهيموجلوبين non-functional أو حتى functional لكن + +174 +00:13:25,040 --> 00:13:30,580 +لا يعمل بالصورة الصحيحة أو المطلوبة فبالتالي يؤدي + +175 +00:13:30,580 --> 00:13:35,120 +لأنيميا bone marrow suppression by toxins أن يصير + +176 +00:13:35,120 --> 00:13:39,360 +تثبيط للـ bone marrow عن طريق الـ toxins عن طريق + +177 +00:13:39,360 --> 00:13:45,420 +بعض الـ chemicals عن طريق الـ radiation عن طريق أن + +178 +00:13:45,420 --> 00:13:50,930 +يصير يكون فيه Malignancy في الجسم مثلًا الجسم صار + +179 +00:13:50,930 --> 00:13:54,550 +فيه Malignancy أو tumor في أي مكان والـ tumor هذه + +180 +00:13:54,550 --> 00:13:58,790 +صار لها انتشار عملت metastasis الـ metastasis هذه + +181 +00:13:58,790 --> 00:14:02,630 +ممكن توصل للـ bone marrow وتحل محل الخلايا + +182 +00:14:02,630 --> 00:14:07,160 +الطبيعية أو قد من خلايا الـ bone marrow نفسها بعض + +183 +00:14:07,160 --> 00:14:10,240 +الخلايا تتحول لـ malignant cells زي حالات اللوكيميا + +184 +00:14:10,240 --> 00:14:14,800 +وتحل محل الخلايا الطبيعية المسؤولة عن تصنيع الخلايا + +185 +00:14:14,800 --> 00:14:19,350 +الـ normal عن تصنيع الـ RBCs الـ normal فبالتالي بتصير + +186 +00:14:19,350 --> 00:14:23,570 +زي .. زي تنافس في المكان الخلايا بتاعة الـ + +187 +00:14:23,570 --> 00:14:28,110 +Malignant cells نشيطة وبتتكثر بسرعة فبتحل محل + +188 +00:14:28,110 --> 00:14:31,030 +الخلايا اللي هي ما هيش Malignant واللي هي بتقوم + +189 +00:14:31,030 --> 00:14:34,910 +بوظيفة تصنيع خلايا الدم الحمراء أو بتقوم بتصنيع + +190 +00:14:34,910 --> 00:14:37,370 +الـ Platelets أو أي حاجة ثانية فبالتالي بتنافس + +191 +00:14:37,370 --> 00:14:43,170 +Malignant cells لأنها سريعة الانتشار هتنافس + +192 +00:14:43,170 --> 00:14:47,440 +الخلايا الـ Normal وتحل محلها وتخليها يصير في قصور + +193 +00:14:47,440 --> 00:14:50,740 +في وظيفتها لأنها ما بتتصنع بالشكل الصحيح في بعض + +194 +00:14:50,740 --> 00:14:54,680 +الأحيان ممكن الـ infection تؤدي إلى أنيميا صحيح في + +195 +00:14:54,680 --> 00:14:58,360 +بعض الحالات اللي ممكن يكون فيها بكتيريا اللي بتسبب + +196 +00:14:58,360 --> 00:15:05,320 +hemolysis للـ RBCs طيب تمام نيجي الآن لتعريف + +197 +00:15:05,320 --> 00:15:10,440 +الانيميا functionally يعني كوظيفة كناحية وظيفية في + +198 +00:15:10,440 --> 00:15:15,490 +الجسم إيش بنعرف الانيميا Anemia is defined as + +199 +00:15:15,490 --> 00:15:21,110 +tissue hypoxia يعني نقص الأكسجين الواصل للأنسجة + +200 +00:15:21,110 --> 00:15:27,190 +نقص الأكسجين هذا بيكون بسبب أنه مافي Hemoglobin + +201 +00:15:27,190 --> 00:15:32,090 +كافي يوصل الأكسجين هذا للأنسجة أو سبب ثاني عندنا + +202 +00:15:32,090 --> 00:15:37,110 +بمحكيه inability of the body to supply tissue with + +203 +00:15:37,110 --> 00:15:41,470 +adequate oxygen for proper metabolic function يعني + +204 +00:15:41,470 --> 00:15:47,270 +أنه إن الـ Blood مش قادر يوصل كمية الـ Oxygen + +205 +00:15:47,270 --> 00:15:50,970 +الكافية لها الأنسجة عشان تشتغل وتقوم بوظائفها + +206 +00:15:50,970 --> 00:15:55,770 +الحيوية المختلفة قد يكون هذا لأن الـ Hemoglobin + +207 +00:15:55,770 --> 00:16:01,550 +نفسه يعني تصنيعه قليل أو فيه خلل فيه نفسه وقد يكون + +208 +00:16:01,550 --> 00:16:06,220 +الـ Hemoglobin Normal وكميته طبيعية أو حتى أكثر من + +209 +00:16:06,220 --> 00:16:10,360 +الطبيعي لكن الـ Hemoglobin هذا بتميز بـ High + +210 +00:16:10,360 --> 00:16:13,260 +Oxygen Affinity زي ما بتعرفوا Hemoglobin F + +211 +00:16:13,260 --> 00:16:16,800 +Hemoglobin F إله Affinity عالية للأكسجين فلمّا + +212 +00:16:16,800 --> 00:16:19,840 +بيوصل للأنسجة بيضلوا ماسك بالأكسجين ما بيعطيها + +213 +00:16:19,840 --> 00:16:24,430 +للأنسجة عشان تستفيد منه فبالتالي وجوده وعدى واحد + +214 +00:16:24,430 --> 00:16:28,390 +لما يكون Hemoglobin F موجود وبنسبة عالية برضه + +215 +00:16:28,390 --> 00:16:32,730 +هيكون هذا الشخص عنده Hypoxia في الأنسجة ومش هيقدر + +216 +00:16:32,730 --> 00:16:40,310 +الوظائف الحيوية مش هتنجز بالشكل المطلوب طيب بشكل + +217 +00:16:40,310 --> 00:16:43,770 +عام بنقول أن الانيميا is not a disease هي ليست مرض + +218 +00:16:43,770 --> 00:16:48,010 +وإنما عرض but rather the expression of an + +219 +00:16:48,010 --> 00:16:51,430 +underlying disorder or disease يعني هي ليست مرض + +220 +00:16:51,430 --> 00:16:58,150 +بحد ذاته وإنما هي يعني نتيجة عرض معين نتيجة خلل + +221 +00:16:58,150 --> 00:17:02,690 +معين أو مرض معين الـ Anemia هنا بقولك أنت ممكن يظهر + +222 +00:17:02,690 --> 00:17:07,310 +عند الشخص هذا Anemia طبعاً إحنا عارفين إنه في توازن + +223 +00:17:07,310 --> 00:17:12,690 +ما بين تصنيع وتكسير هذا طبيعي إحنا عارفينه يعني في + +224 +00:17:13,520 --> 00:17:16,840 +يومياً بدون حالات مرضية بيصير تكسير عدد معين من الـ + +225 +00:17:16,840 --> 00:17:21,340 +RBCs تقريباً 1% وبتصنع مقابل من الـ blood ومقابلهم + +226 +00:17:21,340 --> 00:17:24,700 +بتصنع نفس الكمية خلايا جديدة وبتنزل على الـ + +227 +00:17:24,700 --> 00:17:28,520 +peripheral blood فبالتالي مافي خلل لكن يوم ما يصير + +228 +00:17:28,520 --> 00:17:32,520 +خلل في هذا التوازن يزيد التكسير عن التصنيع إما + +229 +00:17:32,520 --> 00:17:36,840 +بسبب زيادة التكسير أو بسبب الـ bone marrow + +230 +00:17:37,200 --> 00:17:42,440 +suppression أو ضعف في إنتاج الـ bone marrow للخلايا حتى + +231 +00:17:42,440 --> 00:17:46,760 +تنشأ عندنا الانيميا يعني الانيميا طالما اختلف + +232 +00:17:46,760 --> 00:17:50,500 +توازن ما بين الفاقد وما بين المنتج هيصير انيميا + +233 +00:17:50,500 --> 00:17:55,240 +يعني المنتج قليل والفاقد كثير حيصير عندنا حالة + +234 +00:17:55,240 --> 00:18:01,260 +انيميا في حالة ما يصير في انيميا أو hypoxia كيف + +235 +00:18:01,260 --> 00:18:06,660 +الجسم بتصرف hematologic response to anemia الآن لو + +236 +00:18:06,660 --> 00:18:10,560 +صار tissue hypoxia الأنسجة في الجسم هيصير نقص + +237 +00:18:10,560 --> 00:18:17,140 +أكسجين فيها ومن ضمن الأنسجة النسيج تاع الكلى الكلى + +238 +00:18:17,140 --> 00:18:21,500 +هتتنبه أنه صار فيه هيبوكسيا يعني ما بوصلها أكسجين + +239 +00:18:21,500 --> 00:18:27,400 +كفاية فهتروح مباشرة الكلى تطلق هرمون الارثروبويتين + +240 +00:18:28,110 --> 00:18:32,110 +الـ Erythrobiotin هذا بيروح للبون مارو وبيعمل + +241 +00:18:32,110 --> 00:18:39,210 +acceleration لعملية الـ Erythropoiesis يعني بنشط + +242 +00:18:39,210 --> 00:18:43,870 +أو بيعزز عملية الـ Erythropoiesis بقولك يعني ممكن + +243 +00:18:43,870 --> 00:18:49,290 +البون مارو يضاعف نشاطه 7 إلى 8 مرات الوضع الطبيعي + +244 +00:18:49,880 --> 00:18:53,620 +في هذه الحالة الـ bone marrow هيصير hypercellular + +245 +00:18:53,620 --> 00:18:57,240 +طبعاً، مين اللي هيزيد؟ يعني إيش اللي هيصير فعلياً + +246 +00:18:57,240 --> 00:18:59,640 +في الـ bone marrow؟ لأنه لو طلع الـ erythropoietin + +247 +00:18:59,640 --> 00:19:02,960 +بكمية كبيرة أول حاجة، هيصير الـ bone marrow + +248 +00:19:02,960 --> 00:19:07,820 +hypercellular نتيجة زيادة الـ erythroid بـ + +249 +00:19:07,820 --> 00:19:11,560 +precursors، تمام؟ عشان هيك بنسميها erythroid + +250 +00:19:11,560 --> 00:19:15,600 +hyperplasia طبعاً، إحنا عندنا الـ myeloid + +251 +00:19:15,600 --> 00:19:19,990 +هذه، اللي لها ثابتة هنلاقي إن الـ erythroid ratio + +252 +00:19:19,990 --> 00:19:24,630 +Erythroid cells هتزيد تمام فبالتالي النسبة هذه + +253 +00:19:24,630 --> 00:19:30,110 +هتصير قليلة، انخفاض، ليش؟ لأن الـ Erythroid هتزيد + +254 +00:19:30,110 --> 00:19:32,830 +و هذه هتظل ثابتة فبالتالي هيصير انخفاض في الـ + +255 +00:19:32,830 --> 00:19:35,950 +Myeloid Erythroid Ratio إذن أول حاجة الـ bone + +256 +00:19:35,950 --> 00:19:39,110 +marrow hypercellular شغل تاني الـ Myeloid + +257 +00:19:39,110 --> 00:19:43,650 +Erythroid Ratio هيصير لها fall شغل كتير مهمة وهدي + +258 +00:19:43,650 --> 00:19:46,330 +يعني أنا بشوفها في الـ peripheral blood وجود + +259 +00:19:46,330 --> 00:19:53,020 +شغلتان أول حاجة موجود Nucleated RBCs طبعا خلّينا + +260 +00:19:53,020 --> 00:19:58,480 +نتذكر مع بعض هيك شوية احنا عارفين ان الـ RBCs بتمر + +261 +00:19:58,480 --> 00:20:02,880 +بمراحل في التصنيع أول اشي Pro-Normoblast + +262 +00:20:02,880 --> 00:20:07,760 +Normoblast تلت مراحل اللي هي Basophilic + +263 +00:20:07,760 --> 00:20:12,220 +Polychromatic Orthochromic Normoblast لغاية هنا + +264 +00:20:12,220 --> 00:20:16,580 +كله هدف البونمارو تمام؟ لكن + +265 +00:20:18,560 --> 00:20:24,140 +لو صار فيه حاجة لخلايا أو فيه ضغط ممكن يصير الـ + +266 +00:20:24,140 --> 00:20:28,340 +Bone marrow يطلع هذه اللي هي الـ Normoblast اللي + +267 +00:20:28,340 --> 00:20:31,240 +هي الـ Nucleated RBCs على الـ Peripheral Blood + +268 +00:20:31,240 --> 00:20:36,160 +عشان فيه حاجة مهسة إلها فبالتالي هنلاقي فيه ارتفاع + +269 +00:20:36,160 --> 00:20:40,330 +في الـ Nucleated RBCs هذه الشيء في الـ «Blood» فيلم + +270 +00:20:40,330 --> 00:20:44,530 +العادي إذن ممكن نشوف «Nucleated RBC» أو نشوف + +271 +00:20:44,530 --> 00:20:48,150 +«Polychromatic Cell» أو «Polychromagia» فاكرين إيش + +272 +00:20:48,150 --> 00:20:52,570 +يعني Polychromagia؟ فاكرين لما حكينا + +273 +00:20:52,570 --> 00:20:57,190 +«Reticulocyte» + +274 +00:20:57,190 --> 00:21:01,270 +يعني خليني نكمل السلسلة اللي قلناها عشان نشبك + +275 +00:21:01,270 --> 00:21:04,010 +الكلام ببعضه فلقيت إحنا قلنا فينا تلت مراحل + +276 +00:21:04,010 --> 00:21:07,850 +«Normal» و «Blast» بعد التلات مراحل هدول بتيجي عند + +277 +00:21:07,850 --> 00:21:13,230 +الـ reticulocyte صح؟ اللي هي الخلية الشبكية اللي + +278 +00:21:13,230 --> 00:21:20,370 +فيها بقايا من الـ RNA reticulocyte هذه عادة عمرها + +279 +00:21:20,370 --> 00:21:25,370 +كله على بعض 72 يوم عفوا + +280 +00:21:25,370 --> 00:21:30,880 +عفوا sorry 72 ساعة هدول 72 ساعة اللي هم تلت أيام + +281 +00:21:30,880 --> 00:21:33,880 +بتقضي منهم يومين في الـ bone marrow واليوم الأخير + +282 +00:21:33,880 --> 00:21:36,900 +بتقضي في ال peripheral blood فأنا في الوضع الطبيعي + +283 +00:21:36,900 --> 00:21:39,280 +بشوف عدد قليل من ال reticulocyte في ال peripheral + +284 +00:21:39,280 --> 00:21:42,920 +blood وقدرناه إذا كنتوا فاكدين 1% تقريبا من نص إلى + +285 +00:21:42,920 --> 00:21:48,760 +1.5% في ال normal صحيح؟ لكن في ال stress أو تحت + +286 +00:21:48,760 --> 00:21:53,780 +ضغط معين هتبلش ال reticulocyte مجرد ما تتكون، تطلع، + +287 +00:21:53,780 --> 00:21:57,500 +يعني مش هتقض يومين في الـ «بون مارو» و بعدين اتكمل + +288 +00:21:57,500 --> 00:22:01,140 +في الـ «بريفرال بلد»، لأ، هتطلع مباشرة من الـ «بون + +289 +00:22:01,140 --> 00:22:04,580 +مارو» و اتطول في الـ «بريفرال بلد»، فهتبلش تتراكم + +290 +00:22:04,580 --> 00:22:09,380 +تاعت اليوم و تاعت اول امبارح، حتى كمية الـ + +291 +00:22:09,380 --> 00:22:13,500 +reticulocyte بلش تتزيد كتير في الـ «بريفرال بلد» + +292 +00:22:13,500 --> 00:22:16,480 +الـ reticulocyte طبعا أنا في الـ blood film العادي + +293 +00:22:17,420 --> 00:22:21,020 +يعني ما بعدها من الـ Blood Film العادى إذا كنتوا + +294 +00:22:21,020 --> 00:22:23,840 +فاكرين كان لها صبغة خاصة اسمها Supravitalistin + +295 +00:22:23,840 --> 00:22:27,540 +تصبغ الخلية و هي حية لكن في الـ Blood Film العادى + +296 +00:22:27,540 --> 00:22:31,560 +طبعا احنا عارفين الـ RBCs دولها Pink هي مع الـ + +297 +00:22:31,560 --> 00:22:36,910 +Pink بتعطي شوية زرقة فبسميها Polychromagia اللون + +298 +00:22:36,910 --> 00:22:40,130 +الأزرق معين هذا يعني أنا كل الكلام اللي قلته عشان + +299 +00:22:40,130 --> 00:22:43,570 +أذكركم بإيش هي الـ Polychromagia Polychromagia هي + +300 +00:22:43,570 --> 00:22:48,070 +الـ reticular قلاية RBCs هي عبارة أصلا عن + +301 +00:22:48,070 --> 00:22:51,690 +reticulocyte لسه immature RBCs موجودة في الـ + +302 +00:22:51,690 --> 00:22:55,430 +peripheral blood و بتظهر باللون ال pink المطعم أو + +303 +00:22:55,430 --> 00:23:00,690 +الملون باللون الأزرق الخفيف و تتراكم إذن هذه + +304 +00:23:00,690 --> 00:23:05,880 +وجودها بكمية كبيرة مؤشر من مؤشرات الـ Accelerated + +305 +00:23:05,880 --> 00:23:10,680 +Erythropoiesis تمام؟ أو Erythroid Hyperepalgia + +306 +00:23:10,680 --> 00:23:19,480 +تفضيخ + +307 +00:23:19,480 --> 00:23:24,320 +للكلام اللي حكيناه توي أو شرحناه بذكركم هاي الـ + +308 +00:23:24,320 --> 00:23:27,800 +Maturation Series بتاعة ال RVCs هاي هنا الـ + +309 +00:23:27,800 --> 00:23:33,560 +Normoblast التلاتة تلت مراحل لانورموبلاست هيهم بعد + +310 +00:23:33,560 --> 00:23:36,340 +هيك بتجين ال reticulocyte لغاية هنا هذا كله في ال + +311 +00:23:36,340 --> 00:23:39,220 +bone marrow ال reticulocyte بعد يومين من تصنيعها + +312 +00:23:39,220 --> 00:23:42,420 +بتطلع على ال peripheral blood و بتبين باللون اللي + +313 +00:23:42,420 --> 00:23:47,660 +هو الأحمر او الزهري المائل للزرافة هنا هذا الرسمة + +314 +00:23:47,660 --> 00:23:50,720 +بيذكرني او هذه الشريحة بيذكرني فيها في اماكن تصنيع + +315 +00:23:50,720 --> 00:23:55,130 +ال RBCs بقولك لو صار ضغط زيادة على البون مروء + +316 +00:23:55,130 --> 00:23:59,050 +والبون مروء مش قادر يطلع الدم يعني كمية ال blood + +317 +00:23:59,050 --> 00:24:03,510 +اللي لازمة ممكن يرجع يصنع ال blood extra-medullary + +318 +00:24:03,510 --> 00:24:05,750 +احنا عارفين أنه في الـ Adult ميدلاري في الـ Flat + +319 +00:24:05,750 --> 00:24:09,270 +bone في الـ Red marrow في العظام في الأماكن + +320 +00:24:09,270 --> 00:24:12,570 +المحددة في البون مروي اللي هو Red بيصير تصنيع ال + +321 +00:24:12,570 --> 00:24:16,850 +RBC في البون مروي لكن لو صار ضغط و هذا ماقدر يقوم + +322 +00:24:16,850 --> 00:24:20,940 +بالواجب بالشكل الكافيه يرجع التصنيع extra-medullary + +323 +00:24:20,940 --> 00:24:24,400 +يعني هيصير برضه ترجع الـ liver و الـ spleen يتصنع + +324 +00:24:24,400 --> 00:24:27,340 +طبعاً مافيش يوكساك عشان يصنع هو هنا بقولك في + +325 +00:24:27,340 --> 00:24:30,100 +الحياة الجنينية كيف ممكن يكون باليوكساك و في الـ + +326 +00:24:30,100 --> 00:24:32,000 +liver و بالـ spleen بعدين بيصير في الـ bone marrow + +327 +00:24:32,000 --> 00:24:37,600 +لكن ممكن أنه يصير في ال liver و في الـ spine حتى + +328 +00:24:37,600 --> 00:24:40,660 +في الـ adult إذا الجسم بتاعه حاول يصنع من هذا + +329 +00:24:40,660 --> 00:24:44,360 +الجسم قدرة الجسم أنه يعمل adaptation مع الانيميا + +330 +00:24:44,360 --> 00:24:50,010 +يعني بتشوفي واحدة بتقولك أنا دمي سبعة وأنا طول عمري + +331 +00:24:50,010 --> 00:24:53,930 +دم سبعة أنا شوفت واحدة وماشية وعادي وبتشتغل وموظفة + +332 +00:24:53,930 --> 00:24:56,850 +وبتقولك أنا دم سبعة ومنيح لما بيكون سبعة وممكن + +333 +00:24:56,850 --> 00:24:59,690 +يكون ستة وممكن يكون أقل من هاد ولو بتنقليش تم + +334 +00:24:59,690 --> 00:25:03,410 +تقولي لأ أنا خلاص متعودة على هاد هادي صار عندها + +335 +00:25:03,410 --> 00:25:07,150 +adaptation صار عندها تأقلم على هذا الوضع على وضع + +336 +00:25:07,150 --> 00:25:12,250 +الانيميا هادى طبعا هذا بيعتمد على عدة عوامل ال age + +337 +00:25:13,440 --> 00:25:18,100 +والحالة المرضية يعني إيش المرض المصاحب لحالة + +338 +00:25:18,100 --> 00:25:23,200 +الانيميا هذه طبعا ال age كل ما كان العمر أصغر كل + +339 +00:25:23,200 --> 00:25:26,240 +ما كان ال adaptation كل ما كان عند الإنسان قدرة + +340 +00:25:26,240 --> 00:25:29,480 +على ال adaptation أكتر شغلة تانية اللي هي ال + +341 +00:25:29,480 --> 00:25:33,580 +cardio pulmonary function طبعا البنات لو صار + +342 +00:25:33,580 --> 00:25:39,500 +انيميا عند الشخص هيصير overload على ال heart ليش؟ + +343 +00:25:39,500 --> 00:25:43,200 +لأن القلب وظيفته يضخ الدم ويوصل ال oxygen هلقيت لما + +344 +00:25:43,200 --> 00:25:47,900 +الانسجار يكون فيها Hypoxia حيصير القلب يضاعف + +345 +00:25:47,900 --> 00:25:53,380 +مجهوده علشان يوصل Oxygen أكتر للانسجار فإذا كان + +346 +00:25:53,380 --> 00:25:56,880 +القلب والرئتين بتحملوا الكلام هذا السؤال هل هما + +347 +00:25:56,880 --> 00:26:00,600 +بتحملوا ولا في مشكلة أصلا ومع الأنيميا زادت أو + +348 +00:26:00,600 --> 00:26:05,600 +بينت أو انكشفت فبالتالي وظيفة القلب والرئتين مهمة + +349 +00:26:05,600 --> 00:26:12,500 +في موضوع ال adaptation مع الأنيميا شغل تانية Rate + +350 +00:26:12,500 --> 00:26:17,000 +at which anemia develops يعني الأنيميا هادى هل + +351 +00:26:17,000 --> 00:26:20,980 +حصلت فجأة يعني أحسن المثال الشخص هذا أصيب بحادث + +352 +00:26:20,980 --> 00:26:25,840 +ونزف كمية كبيرة من الدم هنا زي بيصير لسه الـ + +353 +00:26:25,840 --> 00:26:29,880 +Bulmar وبدو وقت لما يستوعب الموضوع لكن واحد عنده + +354 +00:26:29,880 --> 00:26:33,380 +نزيف داخلي مثلا لسبب من الأسباب ممكن نزيف بسيط، + +355 +00:26:33,380 --> 00:26:37,140 +نزيف لسه، نزيف مش عارفش وهذا يعني من وقت طويل + +356 +00:26:37,140 --> 00:26:41,960 +وشوية شوية بيصير بشكل chronic طبعا هنا الـ bone + +357 +00:26:41,960 --> 00:26:46,500 +marrow هيبدأ يتعود ويأقلم حاله أنه يعوض هذا الخلل + +358 +00:26:46,500 --> 00:26:53,080 +بطريقة منظمة على خلاف اللي بفقد كميات كبيرة من + +359 +00:26:53,080 --> 00:26:56,520 +الذنب مرة واحدة أنا قلت يعني فقد الذنب كمثال + +360 +00:26:56,940 --> 00:26:59,300 +والانيميا نفس الأشياء يعني أي نوع من أنواع + +361 +00:26:59,300 --> 00:27:02,740 +الانيميا إذا كانت الانيميا بتتطور بطيئا بتعود + +362 +00:27:02,740 --> 00:27:07,500 +عليها الجسم لكن إذا كانت يعني تتكونت فجأة لسبب + +363 +00:27:07,500 --> 00:27:13,060 +مفاجئ لأ الجسم بيكون التعود عليها مش سهل و مش بسيط + +364 +00:27:13,060 --> 00:27:17,080 +ال + +365 +00:27:17,080 --> 00:27:22,460 +symptoms العامة للانيميا أو للـ Hypoxia طبعا هي + +366 +00:27:22,460 --> 00:27:27,410 +أعراض نقص الأكسجين اللي بيوصل للأنسجة بشكل عام، + +367 +00:27:27,410 --> 00:27:32,370 +fatigue، faintness، يعني إرهاق عام لأن العضلات ما + +368 +00:27:32,370 --> 00:27:37,070 +بوصل لها أكسوجين كافي عشان تشتغل كويس، شحوب، ضعف + +369 +00:27:37,070 --> 00:27:42,810 +عام، دوخة، صداع، poor exercise tolerance، لو ماشي + +370 +00:27:42,810 --> 00:27:45,650 +شوية طلع درج بسيريال، هاتوا بتعبوا، بتعرقوا، + +371 +00:27:45,650 --> 00:27:50,610 +مابقدرش يتحمل leg cramps تقلصات في الرجلين في عضلات + +372 +00:27:50,610 --> 00:27:55,090 +الرجلين ليش؟ لأن الرجلين مش قادرين يعني يعني + +373 +00:27:55,090 --> 00:27:58,210 +العضلات مش واصلها أكسوجين كفاية عشان تشتغل + +374 +00:27:58,210 --> 00:28:05,670 +فبالتالي ممكن يصير فيها تشنجات أو تقلصات في + +375 +00:28:05,670 --> 00:28:11,170 +عندنا في بعض الأحيان بعض ال signs بتكون general و + +376 +00:28:11,170 --> 00:28:15,170 +بعضها بتكون specific يعني عندنا general signs زي + +377 +00:28:15,170 --> 00:28:19,270 +شحوب الشحوب هذا عادةً أي واحد Hemoglobinه أقل من 9 + +378 +00:28:19,270 --> 00:28:23,930 +هتلاقي pallor of mucous membrane هتلاقي كل فيه + +379 +00:28:23,930 --> 00:28:27,950 +شحوب عنده يعني لو شفنا جفن العين من جوا هنلاقي فيه + +380 +00:28:27,950 --> 00:28:32,530 +لأن شاحب كتير فاتح كتير مثلا والوجه بشكل عام + +381 +00:28:32,530 --> 00:28:36,510 +بتحسيه شاحب الصداع، الدوخة هذه علامات عامة للأنيميا + +382 +00:28:36,510 --> 00:28:42,190 +لكن في عندي أشياء خاصة ممكن تدلل على نوع الأنميا + +383 +00:28:42,190 --> 00:28:46,950 +زي مثلا الصفار اللي زي الـ Jaundice اليرقان Jaundice + +384 +00:28:46,950 --> 00:28:50,450 +كان بسبب ارتفاع البليروبين طب ماهو ارتفاع + +385 +00:28:50,450 --> 00:28:53,710 +البليروبين؟ بليروبين ارتفاع يعني فيه Hemoglobin + +386 +00:28:53,710 --> 00:28:58,370 +اتكسر يعني فيه تكسير يعني فيه Hemolytic Anemia إذن + +387 +00:28:58,370 --> 00:29:01,430 +وجود Jaundice بقول إنه فيه Hemolytic Anemia بس إيش + +388 +00:29:01,430 --> 00:29:03,750 +نوع الـ Hemolytic Anemia ما بيقولّي بيعطيني + +389 +00:29:03,750 --> 00:29:08,230 +indication على ال category تاعت الأنميا شغل تانية + +390 +00:29:08,230 --> 00:29:12,720 +Leg Ulcers أحياناً بيكون فيه تقرحات في الرجلين أو + +391 +00:29:12,720 --> 00:29:16,920 +في أماكن معينة من الجسم هذه عادةً بتكون من الـ + +392 +00:29:16,920 --> 00:29:19,620 +Sickle Cell Anemia لأن الـ Sickle Cells ممكن تعمل + +393 +00:29:19,620 --> 00:29:23,720 +انسداد للأوعية الدموية الدقيقة و تبدأ الأوعية هذه + +394 +00:29:23,720 --> 00:29:28,100 +لما تسد ما يوصلها أكسجين بشكل كافي فتبدأ تتطور + +395 +00:29:28,100 --> 00:29:34,620 +الأنسجة لمراحل Microsis أو مواد في الأنسجة و Ulcers + +396 +00:29:34,620 --> 00:29:35,340 +and so on + +397 +00:29:38,860 --> 00:29:42,820 +طيب نيجي للـ diagnosis of anemia انا لما بدي اشخص + +398 +00:29:42,820 --> 00:29:46,980 +الانيميا قبل ما اعمل اي diagnosis للانيميا لازم + +399 +00:29:46,980 --> 00:29:56,560 +انتبه لـ six geographical location العمر الجنس + +400 +00:29:56,560 --> 00:30:02,920 +المكان الجغرافي وارتفاعه عن سطح البحر دلوقت بدنا + +401 +00:30:02,920 --> 00:30:06,850 +نشوف كيف بدنا نعمل diagnosis للانيميا clinical + +402 +00:30:06,850 --> 00:30:11,410 +diagnosis of anemia الآن تشخيص الانيميا تلت مراحل + +403 +00:30:11,410 --> 00:30:15,310 +رئيسية ناخد فيها ال patient history و physical + +404 +00:30:15,310 --> 00:30:18,270 +examination و ال lab investigations هناخدهم هيك + +405 +00:30:18,270 --> 00:30:22,170 +على السريع واحدة واحدة بداية ال patient history + +406 +00:30:22,170 --> 00:30:27,350 +بدنا نشوف عادات الغذائية للمريض هل هو من النوع + +407 +00:30:27,350 --> 00:30:31,430 +اللي بيهتم بالغذاء المتكامل الصحي اللي فيه ال + +408 +00:30:31,430 --> 00:30:35,970 +vitamins اللي فيه العناصر الغذائية الرئيسية ولّا + +409 +00:30:35,970 --> 00:30:39,190 +معتمد على الوجبات السريعة الـ junk foods والأشياء + +410 +00:30:39,190 --> 00:30:42,850 +اللي زي هيك طبعا هذه بـ يعني مافيش فيها عناصر + +411 +00:30:42,850 --> 00:30:46,890 +غذائية ممكن تأثر على تعمل أنميا Medications هل + +412 +00:30:46,890 --> 00:30:50,450 +بياخد أدوية معينة؟ ممكن بعض الأدوية تأتي بمردود + +413 +00:30:50,450 --> 00:30:53,710 +سلبي على تصنيع الـ hemoglobin وعلى قدرة الـ bone + +414 +00:30:53,710 --> 00:30:57,750 +marrow وعلى إنتاج الخلايا هل تعرض إلى بعض ال + +415 +00:30:57,750 --> 00:31:01,250 +chemicals مثلا أخد chemicals أخد chemotherapy أو + +416 +00:31:01,250 --> 00:31:06,730 +تعرض لبعض ال toxins؟ description and duration of + +417 +00:31:06,730 --> 00:31:10,330 +symptoms يعني الآن أنت من وقتيش عندك الأعراض هذه + +418 +00:31:10,330 --> 00:31:15,090 +من زمان مثلا طول عمري بعاني من الأعراض هذه من شهر + +419 +00:31:15,090 --> 00:31:18,430 +من أسبوع كل هذا إله دلائل مثلا أخدت علاج وبعد + +420 +00:31:18,430 --> 00:31:21,110 +العلاج هذا بدت معايا الأعراض كلها هذه الـhistory + +421 +00:31:21,110 --> 00:31:26,050 +مهمة عشان الدكتور يكوّن في دماغه صورة متكاملة عن + +422 +00:31:26,050 --> 00:31:29,730 +حالة ال patient هذا ويعرف إيش الخطوة التالية يعني + +423 +00:31:29,730 --> 00:31:34,670 +إيش الخطوة التي تتلي خطوة الـhistory ايش يطلبله + +424 +00:31:34,670 --> 00:31:40,670 +تحليل and so on tiredness يعني هل هو short history + +425 +00:31:40,670 --> 00:31:43,970 +برضه ايش بياخد فيه muscle fatigue or weakness هل + +426 +00:31:43,970 --> 00:31:48,570 +بتعاني من muscle fatigue او weakness headache او + +427 +00:31:48,570 --> 00:31:55,620 +اللي هي الدوخة الدوار او الزغللة dyspnea اللي هي + +428 +00:31:55,620 --> 00:31:58,940 +تسميها صعوبة في التنفس يعني هل مثلا عندك ضيقة نفس + +429 +00:31:58,940 --> 00:32:02,620 +بتحس أنه لما بتيجي تطلع درج لما هدا بتضايق بتزيد + +430 +00:32:02,620 --> 00:32:06,240 +ضربات قلبك ومثلا بيصير عندك صعوبة في التنفس، هل + +431 +00:32:06,240 --> 00:32:09,660 +عندك مشاكل في الـ gastrointestinal tract، overt + +432 +00:32:09,660 --> 00:32:13,100 +signs of blood loss such as هيماتورية، حاجات واضحة + +433 +00:32:13,100 --> 00:32:16,240 +زي الهيماتورية أو black stool، كل هذه دلائل على + +434 +00:32:16,240 --> 00:32:18,580 +إنه في فاقد للدم، في blood loss + +435 +00:32:21,670 --> 00:32:26,310 +طيب نيجي ل الـ Physical Examination برضه هذا يعني + +436 +00:32:26,310 --> 00:32:31,190 +الدكتور اللي .. يعني شغل .. شغل الطبيب مش شغلنا + +437 +00:32:31,190 --> 00:32:35,370 +احنا أول حاجة بشكل عام ممكن يلاقي عنده Hepato + +438 +00:32:35,370 --> 00:32:38,990 +-splenomegaly ليش؟ لأن زي ما قلنا ال liver و ال + +439 +00:32:38,990 --> 00:32:42,350 +spleen بيحسيروا بدهم يتنشطوا من دوره جديد extra + +440 +00:32:42,350 --> 00:32:46,050 +medullary hematopoiesis ويصنعوا دم بيدهم ي sendوا + +441 +00:32:46,050 --> 00:32:51,010 +ال bone marrow عشان يغطوا العجز Heart abnormalities + +442 +00:32:51,010 --> 00:32:53,390 +مشاكل في الـ heart لأن الـ heart هيصير عليه + +443 +00:32:53,390 --> 00:32:56,730 +overload هيصير يشتغل بزيادة عشان يوصل الأكسجين + +444 +00:32:56,730 --> 00:33:01,770 +أكتر للأنسجة skin pallor شحوب في الجلد أو في البشرة + +445 +00:33:01,770 --> 00:33:09,350 +بشكل أكبر طيب specific finding يعني هذه أشياء خاصة + +446 +00:33:09,350 --> 00:33:14,710 +ببعض الحالات المرضية فلقيت مثلا في حالة الـ + +447 +00:33:14,710 --> 00:33:20,010 +vitamin B12 deficiency هتلاقي signs of malnutrition + +448 +00:33:20,010 --> 00:33:24,370 +هنلاقي عند الشخص أعراض سوء التغذية بالإضافة إلى + +449 +00:33:24,370 --> 00:33:29,130 +بعض الأعراض اللي لها علاقة بالأعصاب يعني ممكن + +450 +00:33:29,130 --> 00:33:33,290 +تلاقي مثلا عندها رجفة في إيديها عندها بعض + +451 +00:33:33,290 --> 00:33:39,410 +التشنجات البسيطة في أصابعها هذه ممكن خدل هذه عادة + +452 +00:33:39,410 --> 00:33:43,340 +بقول الدكتور احتمال يكون عندها B12 deficiency هلقد + +453 +00:33:43,340 --> 00:33:47,740 +في الـ iron deficiency مثلا بنلاقي severe pallor + +454 +00:33:47,740 --> 00:33:52,140 +ال tongue بيكون smooth، smooth tongue اللسان and + +455 +00:33:52,140 --> 00:34:00,260 +esophageal webs بتلاقي زي طبقات أو طب بتكون مغطية + +456 +00:34:00,260 --> 00:34:05,430 +ال esophagus in hemolytic anemia عفوًا hemolytic + +457 +00:34:05,430 --> 00:34:08,930 +anemia طبعًا عادة في الـ hemolytic anemia ممكن + +458 +00:34:08,930 --> 00:34:12,410 +ألاقي joints واضح صفار واضح نتيجة وجود باليروبين + +459 +00:34:12,410 --> 00:34:17,790 +وتكثير لل RBCs نتيجة ثالثًا في ال diagnosis + +460 +00:34:17,790 --> 00:34:21,990 +للأنيميا اللي هو ال lab diagnosis اللي هو شغلنا + +461 +00:34:21,990 --> 00:34:26,870 +أول حاجة طبعًا بطلبها الدكتور اللي هو ال CBC CBC + +462 +00:34:26,870 --> 00:34:33,210 +ينطلق منه للأشياء التالية إذا بطلب CBC بطلب blood + +463 +00:34:33,210 --> 00:34:38,530 +smear عشان يعمل evaluation للـ boiculocytosis يشوف + +464 +00:34:38,530 --> 00:34:41,430 +إذا فيها أنزوسيتوزيز إذا فيها ممكن يطلب bone + +465 +00:34:41,430 --> 00:34:45,430 +marrow biopsy bone marrow biopsy ممكن نشوف من + +466 +00:34:45,430 --> 00:34:49,270 +خلالها شوف يا بنات ال bone marrow biopsy يعني + +467 +00:34:49,270 --> 00:34:52,630 +خلينا نكون واقعيين مش كتير بتنطلب يعني بتنطلبش + +468 +00:34:52,630 --> 00:34:56,630 +للأنيميا بتنطلب بس في حالات زي مثلا يعني حالات + +469 +00:34:56,630 --> 00:35:01,710 +فعلا هم مش قادرين يشخصوها حالات ال aplastic anemia + +470 +00:35:01,970 --> 00:35:05,610 +مش يعني مريض الانيميا العادي مابناخدش منه bone + +471 +00:35:05,610 --> 00:35:08,670 +marrow biopsy يعني خلينا نكون في واقعيين و في صورة + +472 +00:35:08,670 --> 00:35:12,890 +الوضع يعني لكن انا بقولك ال bone marrow biopsy لو + +473 +00:35:12,890 --> 00:35:16,130 +احنا عملناها ممكن نشوف ال maturation of RBCs and + +474 +00:35:16,130 --> 00:35:19,820 +WBCs series نشوف نسبة الـ Myeloid للـ Erythroid + +475 +00:35:19,820 --> 00:35:25,520 +abundance of iron stores كمية الـ iron stores مثلاً + +476 +00:35:25,520 --> 00:35:28,580 +هل هي قليلة، هل هي كتيرة، طبعاً في الـ iron + +477 +00:35:28,580 --> 00:35:30,980 +deficiency بيكون قليلة في الـ Sideroblastic anemia + +478 +00:35:30,980 --> 00:35:35,820 +بتزيد and so on presence or absence of granuloma + +479 +00:35:35,820 --> 00:35:40,520 +or tumor cells، يعني هل في مثلاً أثر على تصنيع الدم + +480 +00:35:40,520 --> 00:35:44,280 +وجود خلايا tumor أو cancer أو malignant cells هذه + +481 +00:35:44,280 --> 00:35:48,660 +الخلايا قدت لنقص تصنيع الخلايا الطبيعية Red to + +482 +00:35:48,660 --> 00:35:51,740 +Yellow Ratio طبعا عارفين الـ Red to Yellow Ratio + +483 +00:35:52,020 --> 00:35:54,620 +اللي هي الـ Red bone marrow الـ Active واليالو + +484 +00:35:54,620 --> 00:35:57,800 +اللي هو الـ Inactive فبتشوفوا ال ratio بينه + +485 +00:35:57,800 --> 00:36:01,640 +Presence of megakaryocytes زي ما بقولكم تاني أنه في + +486 +00:36:01,640 --> 00:36:04,600 +الأنميا ما بنطلب bone marrow إلا في بعض الحالات + +487 +00:36:04,600 --> 00:36:07,720 +الصعبة يعني أنا ماباروح أطلب bone marrow عشان أشوف + +488 +00:36:07,720 --> 00:36:11,260 +ال iron stores وانا عندي الحديد في الدم ممكن أشوفه + +489 +00:36:11,260 --> 00:36:13,660 +ال iron و ال total iron binding كبسط زي ما قدنا + +490 +00:36:13,660 --> 00:36:16,900 +نشوفه بس ممكن في ال aplastic anemia في الحالات + +491 +00:36:16,900 --> 00:36:20,200 +اللي يعنيتبقى فعلا أنا شاك كأنه يعني إيش ما أعطي، + +492 +00:36:20,200 --> 00:36:23,280 +إيش ما أعطي، مافيش استجابة وانا شاك كأنه فيه خلل + +493 +00:36:23,280 --> 00:36:25,980 +في البونمارو ممكن يطلبوا بونمارو biopsy أما في + +494 +00:36:25,980 --> 00:36:30,800 +الوضع العادي لأممكن يعملوا Hemoglobin + +495 +00:36:30,800 --> 00:36:34,300 +Electrophoresis طبعا عشان يشوفوا أي أنواع تانية من + +496 +00:36:34,300 --> 00:36:37,900 +الـ Abnormal Hemoglobin زي Hemoglobin S، D، G، + +497 +00:36:37,900 --> 00:36:42,900 +Hemoglobin C كل هذه الأنواع بتظهر الـ Hemoglobin + +498 +00:36:42,900 --> 00:36:45,060 +و Beta طبعا وأنواع الـ Hemoglobin الـ Abnormal + +499 +00:36:45,060 --> 00:36:50,580 +بتظهر في الـ Hemoglobin Electrophoresis ممكن ينطلب + +500 +00:36:50,580 --> 00:36:53,840 +Antiglobulin Testing ممكن ينطلب Osmotic Fragility + +501 +00:36:53,840 --> 00:36:57,710 +Testing ممكن ينطلب Sickle Cell Test ممكن ينطلب + +502 +00:36:57,710 --> 00:37:01,250 +Sucrose Test عشان الـ BNH إذا كنت فاكريني يعني كل + +503 +00:37:01,250 --> 00:37:05,190 +الفحصات اللي احنا درسناها في الـ Hematology اللي + +504 +00:37:05,190 --> 00:37:08,450 +لاتش ممكن ينطلب فحص مثلا Hemoglobin A2 ممكن نعمل + +505 +00:37:08,450 --> 00:37:11,830 +Quantitation لـ Hemoglobin F كل هذه الأشياء ممكن + +506 +00:37:11,830 --> 00:37:15,270 +تنطلب ممكن ينطلب Iron Total Iron Binding Capacity + +507 +00:37:15,270 --> 00:37:18,490 +يعني في مجموعة فحصات Kinestry ممكن تنطلب في بعض + +508 +00:37:18,490 --> 00:37:22,350 +الأحيان Folic Acid Folate Vitamin B12 كله هاد عشان + +509 +00:37:22,350 --> 00:37:25,870 +بالنهاية نعرف إيش النوع الصحيح للأداميا diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/re26D5Gw16M_postprocess.srt b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/re26D5Gw16M_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..5b2586f61fcb74d90f2675a27e4783c0a6d5c265 --- /dev/null +++ b/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/re26D5Gw16M_postprocess.srt @@ -0,0 +1,2036 @@ +1 +00:00:01,690 --> 00:00:06,950 +الله من الشيطان الرجيم بسم الله الرحمن الرحيم إن + +2 +00:00:06,950 --> 00:00:11,690 +شاء الله نلتقي معكم مرة أخرى الفصل هذا في مساق علم + +3 +00:00:11,690 --> 00:00:17,470 +الدم التشخيصي diagnostic hematology زي ما اتكلمنا + +4 +00:00:17,470 --> 00:00:25,230 +مع بعض في ال outlines حكينا إنه المساق هذا بيتعلق + +5 +00:00:25,230 --> 00:00:29,830 +بتشخيص أمراض الدم المختلفة وطبعا أنتوا عارفين أن + +6 +00:00:29,830 --> 00:00:34,590 +أمراض الدم تقريبابتتقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +التلاتة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش أني أحفظ إيش تعريف الانيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش ال pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط النتائج هذه مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مساحبة لهذا ال result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات عشان أتأكد من الـresults معينة هذا + +20 +00:01:32,370 --> 00:01:36,270 +الكلام بإذن الله كله راح نناقشه مع بعض شويه شويه + +21 +00:01:36,270 --> 00:01:40,390 +أول حاجة هنشرحه بعد هيك هناخد عليه أمثلة تبقية على + +22 +00:01:40,390 --> 00:01:43,470 +شكل حالات مرضية طبعا محاضرتنا هيكون فيها مجموعة من + +23 +00:01:43,470 --> 00:01:48,410 +الأهداف في النهاية راح يكون عندنا القدرة على إنه + +24 +00:01:48,410 --> 00:01:51,950 +نعرف الأنيميا راح نلاقي الأنيميا إلها أكتر من + +25 +00:01:51,950 --> 00:01:56,960 +تعريف ما شاء الله رب العالمين هنشوف مع بعضإيش هي + +26 +00:01:56,960 --> 00:02:00,820 +التعريفات الصحيحة وفي ناس يعني في تعريفات اللي لها + +27 +00:02:00,820 --> 00:02:04,680 +علاقة بالمختبر وفي تعريفات اللي لها علاقة بالأطباء + +28 +00:02:04,680 --> 00:02:09,080 +فهنشوف التعريفات المختلفة اللي لها راح يكون عندنا + +29 +00:02:09,080 --> 00:02:16,720 +القدرة على مناقشة أسباب الانيميا ال clinical + +30 +00:02:16,720 --> 00:02:19,940 +significance لال categories المختلفة برضه من + +31 +00:02:19,940 --> 00:02:24,740 +الانيميا راح نعرف انصنف أنواع الانيميا المختلفة + +32 +00:02:25,610 --> 00:02:30,490 +نقدر في النهاية نقول هذه مثلا microcytic anemia + +33 +00:02:30,490 --> 00:02:33,870 +هذه macrocytic anemia هذه normocytic مثلا + +34 +00:02:33,870 --> 00:02:39,310 +normochromic anemia فنقدر نصنف الانيميا حسب قراتي + +35 +00:02:39,310 --> 00:02:44,910 +للنتائج لأحد الأنواع الرئيسية فيها يكون عندنا + +36 +00:02:44,910 --> 00:02:50,350 +القدرة على أننا نناقش نتائج النتائج اللي بحصل + +37 +00:02:50,350 --> 00:02:58,000 +عليها في المختبروأقدر أنثب هذه النتائج لأحد ال + +38 +00:02:58,000 --> 00:03:01,940 +categories من الانيميا يعني مثلا شوف ال CPC أول + +39 +00:03:01,940 --> 00:03:04,800 +حاجة بدي أطلع مثلا على ال Hemoglobin Hemoglobin + +40 +00:03:04,800 --> 00:03:09,160 +واطي إذا انانيميا طيب إيش نوعها مثلا هي microcytic + +41 +00:03:09,160 --> 00:03:12,120 +hypochromic and so on و أسير أربط النتائج هادة + +42 +00:03:12,120 --> 00:03:15,530 +بعضهاperform basic laboratory test for the + +43 +00:03:15,530 --> 00:03:20,190 +diagnosis of anemia كيف؟ طبعاً هذا الشخصية هذه + +44 +00:03:20,190 --> 00:03:22,830 +الـbasic laboratory test for diagnosis of anemia + +45 +00:03:22,830 --> 00:03:25,990 +طبعاً هذه احنا شغلناها بالتفصيل في مساقع الدم + +46 +00:03:25,990 --> 00:03:28,390 +السريري اللي هي الفصوات الأساسية اللي لازم تشتر في + +47 +00:03:28,390 --> 00:03:30,810 +الانميا ال outlines هيكون بداية عندنا definition + +48 +00:03:30,810 --> 00:03:37,730 +of anemia classification of anemia برضه يعني هيكون + +49 +00:03:37,730 --> 00:03:41,790 +عندنا بعض النقاط هناخدها ال hematologic response + +50 +00:03:41,790 --> 00:03:46,750 +to anemiaSigns of Accelerated Bone Erythropoiesis + +51 +00:03:46,750 --> 00:03:50,730 +إيش بيصير لما البون مار يصير يشغل تحت stress + +52 +00:03:50,730 --> 00:03:54,510 +Physiologic Response to Anemia Methods of + +53 +00:03:54,510 --> 00:03:59,570 +Classification Anemia Diagnosis and Causes أسبابها + +54 +00:03:59,570 --> 00:04:03,970 +وتشخيصها Lab Investigation of Anemia كيف إحنا نشخص + +55 +00:04:03,970 --> 00:04:08,650 +الأنيميا في المختبر؟ هيكون عندنا طبعا أنواع + +56 +00:04:08,650 --> 00:04:14,240 +الأنيميا Microcytic Hypochromicنورموسيتك مثلا + +57 +00:04:14,240 --> 00:04:17,800 +نورموسيتك أنيميا نورموسيتك أنيميا due to + +58 +00:04:17,800 --> 00:04:20,760 +hemoglobin and pathase طبعا كل هذه أشياء راح + +59 +00:04:20,760 --> 00:04:27,100 +ناخدها بإذن الله بالتفصيل طيب + +60 +00:04:27,100 --> 00:04:31,420 +نحاول نعرف الأنيميا مع بعض لو جيت قلتلكم عرفولي + +61 +00:04:31,420 --> 00:04:37,600 +الأنيميا أكيد هتقولولي نقص ال RBCs نقص الهمoglobin + +62 +00:04:37,600 --> 00:04:42,740 +نقص ال hematocrit يعني هي نقصالـ Oxygen-carrying + +63 +00:04:42,740 --> 00:04:47,700 +components of blood بالظبط نقص الـ Oxygen-carrying + +64 +00:04:47,700 --> 00:04:51,140 +components مين هي أهم حاجة بيحمل الأكسجين؟ طبعاً + +65 +00:04:51,140 --> 00:04:54,080 +زي ما انتوا عارفين الـ Hemoglobin فبالتالي + +66 +00:04:54,080 --> 00:04:58,120 +الأناميا is a decrease in the RBCs count + +67 +00:04:58,120 --> 00:05:02,680 +Hemoglobin or Hematocrit طبعاً لو أنا قارنتهم بالـ + +68 +00:05:02,680 --> 00:05:06,200 +Normal Range وانتوا عارفين ان احنا لما بنقارن بـ + +69 +00:05:06,200 --> 00:05:11,680 +Rangeكل فئة عمرية لها range وبرضه related to sex + +70 +00:05:11,680 --> 00:05:15,680 +المال يختلف عن الفيمال فبالتالي لما أنا بدي أقارن + +71 +00:05:15,680 --> 00:05:22,720 +أقارن بال range المخصص لهذه الفئة العمرية وهذا ال + +72 +00:05:22,720 --> 00:05:28,440 +gender طيب نيجي لتعريف + +73 +00:05:28,440 --> 00:05:32,420 +أو تفريق ما بين شغلتان true anemia and pseudo + +74 +00:05:32,420 --> 00:05:37,830 +anemia لـ true anemiaبتبقى عندى الـ blood + +75 +00:05:37,830 --> 00:05:44,670 +components قليلة تمام و الـ plasma volume normal + +76 +00:05:44,670 --> 00:05:51,310 +decreased RBCs mass and normal plasma volume كويس؟ + +77 +00:05:51,310 --> 00:05:55,870 +يعني مين اللي بنقص عندى؟ الـ RBCs السودوانيميا + +78 +00:05:55,870 --> 00:06:00,890 +السودوانيميا مختلفة فإن كمية الـ RBCs مابتكونش + +79 +00:06:00,890 --> 00:06:06,550 +قليلة لكن بصيرلها dilutionيعني بيصير تخفيف للدم + +80 +00:06:06,550 --> 00:06:12,270 +فبالتالي نظرا لأن ال blood اتخفف زادت كمية ال + +81 +00:06:12,270 --> 00:06:16,730 +fluids اللي فيه كل مقاجي أقيس حاجة أو أقرأها هلاقي + +82 +00:06:16,730 --> 00:06:20,670 +تركيزها قليل لأنه صار لها فعليا dilution بس هي ما + +83 +00:06:20,670 --> 00:06:25,290 +ناقص تصنيعها هي المشكلة أنه حصل dilution وهذه حاجة + +84 +00:06:25,290 --> 00:06:29,310 +عادة بتكون مؤقتة بنسميها pseudoanemia أو + +85 +00:06:29,310 --> 00:06:33,990 +dilutional anemia normal RBCs massand increase + +86 +00:06:33,990 --> 00:06:38,750 +plasma volume طبعاً هذه ممكن تصير في حالات ال + +87 +00:06:38,750 --> 00:06:43,990 +pregnancy أو في حالات ال volume overload الناس + +88 +00:06:43,990 --> 00:06:47,970 +اللي بتاخد intravenous fluid محلول وريدي و بتكون + +89 +00:06:47,970 --> 00:06:51,210 +كميته كتير كبيرة ممكن يعمل dilution لل blood في + +90 +00:06:51,210 --> 00:06:54,330 +حالات ال congestive heart failure يعني عضلة القلب + +91 +00:06:54,330 --> 00:06:59,280 +مش قادرة تستوعب الدم اللي جايها عشان تعملهبنقله + +92 +00:06:59,280 --> 00:07:03,960 +للرقى ويصير له أكسجر فبصير تجمع لاستوائل فيه خاصة + +93 +00:07:03,960 --> 00:07:07,740 +الجزء اليمين من الجسم وبالتالي بيصير dilution + +94 +00:07:07,740 --> 00:07:13,920 +للبلد طيب هذه عادة بلاقي ال hemoglobin و ال + +95 +00:07:13,920 --> 00:07:18,080 +hematocrit فيها low ليش؟ لأنه صار home dilution مش + +96 +00:07:18,080 --> 00:07:21,180 +لأنه صار نقص في تصنيع ال RBC أو خلل في تصنيع ال + +97 +00:07:21,180 --> 00:07:25,740 +hemoglobin أو ال RBC لأ هنا دراسة طبيعية تظهر عندي + +98 +00:07:25,740 --> 00:07:30,920 +الفرق ما بين ال normal anemiaand الـ Normal عفواً + +99 +00:07:30,920 --> 00:07:35,560 +والـ True Anemia والـ Pseudo Anemia لو تخيلنا عينة + +100 +00:07:35,560 --> 00:07:40,400 +الـ blood بهذا الشكل Hemoglobin فيها 15 الـ + +101 +00:07:40,400 --> 00:07:44,980 +hematocrit 45% عند الـ Normal احنا عارفين 45% + +102 +00:07:44,980 --> 00:07:47,220 +hematocrit طبعا زي ما احنا عارفين ان الـ + +103 +00:07:47,220 --> 00:07:53,960 +hematocrit بيمثل نسبة ال RBC في العينة يعني 45% من + +104 +00:07:53,960 --> 00:07:59,520 +ال sample كلها هتكون hematocrit هتكون RBCتمام؟ هدو + +105 +00:07:59,520 --> 00:08:04,060 +الوضع الطبيعي هلأ في الـ True Anemia هتلاقي أنه + +106 +00:08:04,060 --> 00:08:09,320 +الـ hematocrit قل يعني الـ RBCs نفسها قلت في حين + +107 +00:08:09,320 --> 00:08:13,200 +أنه الـ plasma volume طبيعي يعني لو أجيني أقارنها + +108 +00:08:13,200 --> 00:08:15,820 +الـ plasma volume هذا بال normal plasma volume + +109 +00:08:15,820 --> 00:08:20,300 +هنلاقيهم زي بعض بس مين اللي نقص؟ نقصة الـ RBCs + +110 +00:08:20,300 --> 00:08:25,380 +mass فعليا هنا هتلاقي الـ hematocrit مثلا 30% + +111 +00:08:25,380 --> 00:08:30,660 +والهمoglobin 10هذه حالة أنيميا حقيقية ليش؟ لأن + +112 +00:08:30,660 --> 00:08:35,000 +البلازما حجمها ما اتأثر مقارنة بالنورمال بينما + +113 +00:08:35,000 --> 00:08:39,780 +كمية ال RBCs هي اللي نقصت لو أجينا نشوف + +114 +00:08:39,780 --> 00:08:43,480 +السودوانيميا هنلاقي كمية ال RBCs زيها زي النورمال + +115 +00:08:43,480 --> 00:08:48,280 +لكن كمية البلازما زادت فصار dilution لكل ال + +116 +00:08:48,280 --> 00:08:52,820 +parameters هنلاقي ال hematocrit صار 30% زي وزي ال + +117 +00:08:52,820 --> 00:08:58,340 +true anemia لكن هو فعليا كمية ال RBCsحقيقية زي ما + +118 +00:08:58,340 --> 00:09:01,600 +هي Normal والتصنيعها Normal بس المشكلة أنه صار + +119 +00:09:01,600 --> 00:09:06,820 +Hemodilution بسبب زيادة حجم البلازما وهنا شايفين + +120 +00:09:06,820 --> 00:09:11,260 +طبعا التمثيل للـ 3 حالات للـ Normal و للـ True + +121 +00:09:11,260 --> 00:09:16,220 +Anemia و للـ Pseudo Anemia بشكل يعني واضح احنا + +122 +00:09:16,220 --> 00:09:23,780 +اللي بتهمنا اللي هي الـ True Anemia طيب، + +123 +00:09:23,780 --> 00:09:28,750 +في عندنا ملاحظة مهمة جدايعني يا بنات ممكن تنتين + +124 +00:09:28,750 --> 00:09:35,810 +فيكم يعملوا CBC التنتين يطلعولي يطلع دمهم مثلا 11 + +125 +00:09:35,810 --> 00:09:39,590 +gram per deciliter الهيموجلوبين 11 gram per + +126 +00:09:39,590 --> 00:09:45,730 +deciliter أقول لسين أنت هيموجلوبينك كويس وأقول + +127 +00:09:45,730 --> 00:09:51,050 +لصاد أنت هيموجلوبينك مش كويس ليش؟ خلّيني أفكر + +128 +00:09:51,050 --> 00:09:54,900 +فيها، مع أن التنتين في نفس العمرو نفس الظروف + +129 +00:09:54,900 --> 00:09:58,880 +تقريبا و في نفس البيئة عايشين و ليش انا اعتبرت هذي + +130 +00:09:58,880 --> 00:10:03,140 +Normal و هذي Abnormal فنسين قلتلها ان انت كويسة + +131 +00:10:03,140 --> 00:10:06,920 +لأن انا طول عمري او اكتر من مرة اتجيب لـ CBC يكون + +132 +00:10:06,920 --> 00:10:12,260 +هذا هو ال range الطبيعي لها يعني 11، 11.5، 10.5 هي + +133 +00:10:12,260 --> 00:10:15,800 +دمها هيك ايش ما تعمل مش هيزيد عن هيك لكن التانية + +134 +00:10:15,800 --> 00:10:19,580 +كان دمها 13 انا عارفة ان قبل هيك عملت ال + +135 +00:10:19,580 --> 00:10:24,470 +hemoglobin كان 13 و أجتنياليوم بـ 11 بقولها لأ انت + +136 +00:10:24,470 --> 00:10:28,950 +hemoglobinك نازل اذا ضروري عشان احكم على انسان انه + +137 +00:10:28,950 --> 00:10:32,990 +عنده anemiaيكون فيه فرق بين قراءته الحالية + +138 +00:10:32,990 --> 00:10:38,970 +والقراءات اللي عادة هو يحصل عليها لما بيعمل CBC + +139 +00:10:38,970 --> 00:10:43,170 +تمام؟ «Anemia must also relate to the level of + +140 +00:10:43,170 --> 00:10:46,750 +hemoglobin the individual normally bosses» لازم + +141 +00:10:46,750 --> 00:10:51,770 +أقارنه بالقيمة الطبيعية لهذا الشخص اللي عادة بيكون + +142 +00:10:51,770 --> 00:10:56,330 +الـ hemoglobin بهذا الشكل هنا ضريب لمثالIf an + +143 +00:10:56,330 --> 00:11:00,190 +adult male usually maintains a hemoglobin level 16 + +144 +00:11:00,190 --> 00:11:04,230 +gram per deciliter هو عادة بياخد هذا الرقم 16 gram + +145 +00:11:04,230 --> 00:11:08,650 +per deciliter لكن بعد فترة لاقينا أن الـ + +146 +00:11:08,650 --> 00:11:14,550 +hemoglobin صار 14 لأ هذا معنى الكلام أنه فيه مشكلة + +147 +00:11:14,550 --> 00:11:19,050 +نزلت الأثنين جرام هدول بده متابعة ونشوف إذا كان + +148 +00:11:19,050 --> 00:11:22,050 +صار خلل معين نحاول انعالجه، تمام؟ + +149 +00:11:27,500 --> 00:11:30,840 +عنا مجموعة من الحالات المرضية أنا هيك بحكي roughly + +150 +00:11:30,840 --> 00:11:36,120 +بشكل عام اللي ممكن تكون مسببات لنقص الـ hemoglobin + +151 +00:11:36,120 --> 00:11:40,860 +nutritional deficiencies يعني نقص في المواد + +152 +00:11:40,860 --> 00:11:46,980 +الغذائية قد يكون نقص في قاش، في الحديد، تقم واحد + +153 +00:11:46,980 --> 00:11:51,360 +أول إش تتذكره في الفوليك أسد، في الفوليت أو فوليك + +154 +00:11:51,360 --> 00:11:54,900 +أسد، في vitamin B12 كلها هذه أسباب تؤدي إلى + +155 +00:11:54,900 --> 00:11:59,520 +الأنمياإذن هذه nutritional deficiencies External + +156 +00:11:59,520 --> 00:12:04,480 +or internal blood loss فقد الدم على فترات قد يكون + +157 +00:12:04,480 --> 00:12:10,460 +فقد الدم acute ويؤدي لهبوط في الدم في الـ + +158 +00:12:10,460 --> 00:12:14,600 +hemoglobin وقد يكون chronic إن الإنسان هذا بفقد + +159 +00:12:14,600 --> 00:12:18,620 +كميات بسيطة من الدم على فترات زمنية طويلة فبالتالي + +160 +00:12:18,620 --> 00:12:24,140 +بينشأ عنها أنميا Increased extraction of RBCsتكسير + +161 +00:12:24,140 --> 00:12:28,580 +الـ RBCs لأي سبب من الأسباب قد يكون سبب مناعي قد + +162 +00:12:28,580 --> 00:12:32,380 +يكون يعني في مسببات كتير ممكن تعمل تكسير للـ blood + +163 +00:12:32,380 --> 00:12:35,800 +راح ناخدها ان شاء الله في الـ hemolytic anemia طيب + +164 +00:12:35,800 --> 00:12:39,780 +ineffective or decreased production of RBCs يعني + +165 +00:12:39,780 --> 00:12:42,740 +في مشكلة في ال production للـ RBCs الـ RBCs ما + +166 +00:12:42,740 --> 00:12:50,490 +بتنتج بشكل طبيعي نتيجة خلل معينفي العناصر أو في + +167 +00:12:50,490 --> 00:12:53,810 +الأشياء اللي لازمة لتصنيعها فبالتالي ما بتتصنع + +168 +00:12:53,810 --> 00:12:58,610 +بالشكل السليم abnormal hemoglobin synthesis طبعا + +169 +00:12:58,610 --> 00:13:02,470 +احنا عارفين ان الـ hemoglobin بتتكون من الـ 2α2β- + +170 +00:13:02,470 --> 00:13:10,030 +و الهم طبعا الـ globin اللي هو 2α2β- ممكن يصير فيه + +171 +00:13:10,030 --> 00:13:14,790 +mutations مختلفة و متعددة الـ mutations هذه عادة + +172 +00:13:14,790 --> 00:13:21,380 +تؤدي إلىحدوث خلل في الهيموجلوبين قد يكون هذا + +173 +00:13:21,380 --> 00:13:25,040 +الهيموجلوبين non-functional أو حتى functional لكن + +174 +00:13:25,040 --> 00:13:30,580 +لا يعمل بالصورة الصحيحة أو المطلوبة فبالتالي يؤدي + +175 +00:13:30,580 --> 00:13:35,120 +لانميا bone marrow suppression by toxins أن يصير + +176 +00:13:35,120 --> 00:13:39,360 +تثبيت للـ bone marrow عن طريق الـ toxins عن طريق + +177 +00:13:39,360 --> 00:13:45,420 +بعض الchemicals عن طريق ال radiation عن طريق أن + +178 +00:13:45,420 --> 00:13:50,930 +يصيريكون فيه Malignancy في الجسم مثلًا الجسم صار + +179 +00:13:50,930 --> 00:13:54,550 +فيه Malignancy أو tumor في أي مكان والـ tumor هذه + +180 +00:13:54,550 --> 00:13:58,790 +صار لها انتشار عملت metastasis الـ metastasis هذه + +181 +00:13:58,790 --> 00:14:02,630 +ممكن توصل للـ bone marrow وتحل محل الخلايا + +182 +00:14:02,630 --> 00:14:07,160 +الطبيعيةأو قد من خلايا الـ bone marrow نفسها بعض + +183 +00:14:07,160 --> 00:14:10,240 +الخلايا تتحول لماليجنان cells زي حالات اللوكيميا + +184 +00:14:10,240 --> 00:14:14,800 +وتحل محل الخلايا الطبيعية لمسؤولة عن تصنيع الخلايا + +185 +00:14:14,800 --> 00:14:19,350 +الـnormal عن تصنيع الـRBCs الـnormalفبالتالي بتصير + +186 +00:14:19,350 --> 00:14:23,570 +زي .. زي تنافس في المكان الخلايا بتاعة الـ + +187 +00:14:23,570 --> 00:14:28,110 +Malignant cells نشيطة و بتتكثر بسرعة فبتحل محل + +188 +00:14:28,110 --> 00:14:31,030 +الخلايا اللي هي ماهياش Malignant و اللي هي بتقوم + +189 +00:14:31,030 --> 00:14:34,910 +بوظيفة تصنيع خلايا الدم الحمراء أو بتقوم بتصنيع + +190 +00:14:34,910 --> 00:14:37,370 +الـ Platelets أو أي حاجة تانية فبالتالي بتنافس + +191 +00:14:37,370 --> 00:14:43,170 +Malignant cells لأنها سريعة الانتشار هتنافس + +192 +00:14:43,170 --> 00:14:47,440 +الخلايا الـ Normalوتحل محلها و تخليها يصير في قصور + +193 +00:14:47,440 --> 00:14:50,740 +في وظيفتها لأنها ما بتتصنع بالشكل الصحيح في بعض + +194 +00:14:50,740 --> 00:14:54,680 +الأحيان ممكن ال infection تؤدي إلى أنيميا صحيح في + +195 +00:14:54,680 --> 00:14:58,360 +بعض الحالات اللي ممكن يكون فيها بكتيريا اللي بتسبب + +196 +00:14:58,360 --> 00:15:05,320 +hemolysis لل RBCs طيب تمام نيجي الآن لتعريف + +197 +00:15:05,320 --> 00:15:10,440 +الانيميا functionally يعني كوظيفة كناحية وظيفية في + +198 +00:15:10,440 --> 00:15:15,490 +الجسم إيش بنعرف الانيمياAnemia is defined as + +199 +00:15:15,490 --> 00:15:21,110 +tissue hypoxia يعني نقص الأكسجين الواصل للأنسجة + +200 +00:15:21,110 --> 00:15:27,190 +نقص الأكسجين هذا بيكون بسبب أنه مافي Hemoglobin + +201 +00:15:27,190 --> 00:15:32,090 +كافي يوصل الأكسجين هذا للأنسجة أو سبب تاني عندنا + +202 +00:15:32,090 --> 00:15:37,110 +بمحكيه inability of the body to supply tissue with + +203 +00:15:37,110 --> 00:15:41,470 +adequate oxygen for proper metabolic function يعني + +204 +00:15:41,470 --> 00:15:47,270 +أنهإن الـ Blood مش قادر يوصل كمية الـ Oxygen + +205 +00:15:47,270 --> 00:15:50,970 +الكافية لها الأنسجة عشان تشتغل وتقوم بوظائفها + +206 +00:15:50,970 --> 00:15:55,770 +الحيوية المختلفة قد يكون هذا لأن الـ Hemoglobin + +207 +00:15:55,770 --> 00:16:01,550 +نفسه يعني تصنيعه قليل أو فيه خلل فيه نفسه وقد يكون + +208 +00:16:01,550 --> 00:16:06,220 +الـ Hemoglobin Normalوكميته طبيعية أو حتى أكتر من + +209 +00:16:06,220 --> 00:16:10,360 +الطبيعي لكن الـ Hemoglobin هذا بتميز بـ High + +210 +00:16:10,360 --> 00:16:13,260 +Oxygen Affinity زي ما بتعرفوا Hemoglobin F + +211 +00:16:13,260 --> 00:16:16,800 +Hemoglobin F إله Affinity عالية للأكسجين فلمّا + +212 +00:16:16,800 --> 00:16:19,840 +بيوصل للأنسجة بيضلوا ماسك بالأكسجين ما بيعطيها + +213 +00:16:19,840 --> 00:16:24,430 +للأنسجة عشان تستفيد منهفبالتالي وجوده وعدى مواحد + +214 +00:16:24,430 --> 00:16:28,390 +لما يكون Hemoglobin F موجود وبنسبة عالية برضه + +215 +00:16:28,390 --> 00:16:32,730 +هيكون هذا الشخص عنده Hypoxia في الانسجار ومش هيقدر + +216 +00:16:32,730 --> 00:16:40,310 +الوظائف الحيوانية مش هتنجز بالشكل المطلوب طيب بشكل + +217 +00:16:40,310 --> 00:16:43,770 +عام بنقول أن الانيميا is not a disease هي ليست مرض + +218 +00:16:43,770 --> 00:16:48,010 +وانما عرضbut rather the expression of an + +219 +00:16:48,010 --> 00:16:51,430 +underlying disorder or disease يعني هي ليست مرض + +220 +00:16:51,430 --> 00:16:58,150 +بحد ذاته وإنما هي يعني نتيجة عرض معين نتيجة خلل + +221 +00:16:58,150 --> 00:17:02,690 +معين أو مرض معين الـAnemia هنا بقولك أنت ممكن يظهر + +222 +00:17:02,690 --> 00:17:07,310 +عند الشخص هذا Anemia طبعا إحنا عارفين إنه في توازن + +223 +00:17:07,310 --> 00:17:12,690 +ما بين تصنيع وتكسير هذا طبيعي إحنا عارفينه يعني في + +224 +00:17:13,520 --> 00:17:16,840 +يوميا بدون حالات مرضية بيصير تكسير عدد معين من الـ + +225 +00:17:16,840 --> 00:17:21,340 +RBCs تقريبا 1% وبتصنع مقابل من ال blood ومقابلهم + +226 +00:17:21,340 --> 00:17:24,700 +بتصنع نفس الكمية خلايا جديدة وبتنزل على ال + +227 +00:17:24,700 --> 00:17:28,520 +peripheral blood فبالتالي مافي خلل لكن يوم ما يصير + +228 +00:17:28,520 --> 00:17:32,520 +خلل في هذا التوازن يزيد التكسير عن التصنيع إما + +229 +00:17:32,520 --> 00:17:36,840 +بسبب زيادة التكسير أو بسبب ال bone marrow + +230 +00:17:37,200 --> 00:17:42,440 +submission أو ضعف في إنتاج الـ Boomer للخلايا حتى + +231 +00:17:42,440 --> 00:17:46,760 +تنشأ عندنا الانيميا يعني الانيميا طالما اختلف + +232 +00:17:46,760 --> 00:17:50,500 +توازن ما بين الفاقد و ما بين المنتج هيصير انيميا + +233 +00:17:50,500 --> 00:17:55,240 +يعني المنتج قليل و الفاقد كتير حيصير عندنا حالة + +234 +00:17:55,240 --> 00:18:01,260 +انيميا في حالة ما يصير في انيميا أو hypoxia كيف + +235 +00:18:01,260 --> 00:18:06,660 +الجسم بتصرف hematologic response to anemiaالان لو + +236 +00:18:06,660 --> 00:18:10,560 +صار تيشو هيبوكسيا الانسجا في الجسم هيصير نقص + +237 +00:18:10,560 --> 00:18:17,140 +أكسوجين فيها ومن ضمن الانسجا النسيج تاع الكدن كدني + +238 +00:18:17,140 --> 00:18:21,500 +هتتنبه أنه صار فيه هيبوكسيا يعني ما بوصلها أكسوجين + +239 +00:18:21,500 --> 00:18:27,400 +كفاية فهتروح مباشرة الكدن تطلق هرمون الارثروبيوتين + +240 +00:18:28,110 --> 00:18:32,110 +الـ Erythrobiotin هذا بيروح للبون مارو و بعمل + +241 +00:18:32,110 --> 00:18:39,210 +acceleration لعملية الـ Erythropoiesis يعني بنشط + +242 +00:18:39,210 --> 00:18:43,870 +أو بحفظ عملية الـ Erythropoiesis بقولك يعني ممكن + +243 +00:18:43,870 --> 00:18:49,290 +البون مارو يضاعف نشاطه 7 إلى 8 مرات الوضع الطبيعي + +244 +00:18:49,880 --> 00:18:53,620 +في هذه الحالة الـ bone marrow هيصير hypercellular + +245 +00:18:53,620 --> 00:18:57,240 +طبعاً، مين اللي هيزيد؟ يعني إيش اللي هيصير فعلياً + +246 +00:18:57,240 --> 00:18:59,640 +في الـ bone marrow؟ لأنه لو طلع الـ erythropoietin + +247 +00:18:59,640 --> 00:19:02,960 +بكمية كبيرة أول حاجة، هيصير الـ bone marrow + +248 +00:19:02,960 --> 00:19:07,820 +hypercellular نتيجة زيادة الـ erythroid بـ + +249 +00:19:07,820 --> 00:19:11,560 +precursors، تمام؟ عشان هيك بنسميها erythroid + +250 +00:19:11,560 --> 00:19:15,600 +hyperplasia طبعاً، إحنا عندنا الـ myeloid + +251 +00:19:15,600 --> 00:19:19,990 +erythroid ratio هذه، اللي لها ثابتةهنلاقي إن الـ + +252 +00:19:19,990 --> 00:19:24,630 +Erythroid cells هتزيد تمام فبالتالي النسبة هذه + +253 +00:19:24,630 --> 00:19:30,110 +هتصير قليلة، انخفاض، ليش؟ لأن الـ Erythroid هتزيد + +254 +00:19:30,110 --> 00:19:32,830 +و هذه هتظل ثابتة فبالتالي هيصير انخفاض في الـ + +255 +00:19:32,830 --> 00:19:35,950 +Myeloid Erythroid Ratio إذن أول حاجة الـ bone + +256 +00:19:35,950 --> 00:19:39,110 +marrow hypercellular شغل تاني الـ Myeloid + +257 +00:19:39,110 --> 00:19:43,650 +Erythroid Ratio هيصير لها fall شغل كتير مهمة وهدي + +258 +00:19:43,650 --> 00:19:46,330 +يعني أنا بشوفها في الـ peripheral blood وجود + +259 +00:19:46,330 --> 00:19:53,020 +شغلتان أول حاجةموجود Nucleated RBCs طبعا خلّينا + +260 +00:19:53,020 --> 00:19:58,480 +نتذكر مع بعض هيك شوية احنا عارفين ان الـ RBCs بتمر + +261 +00:19:58,480 --> 00:20:02,880 +بمراحل في التصنيع أول اشي Pro-Normoblast + +262 +00:20:02,880 --> 00:20:07,760 +Normoblast تلت مراحل اللي هي Basophilic + +263 +00:20:07,760 --> 00:20:12,220 +Polychromatic Orthochromic Normoblast لغاية هنا + +264 +00:20:12,220 --> 00:20:16,580 +كله هدف البونمارو تمام؟ لكن + +265 +00:20:18,560 --> 00:20:24,140 +لو صار فيه حاجة لخلايا أو فيه ضغط ممكن يصير الـ + +266 +00:20:24,140 --> 00:20:28,340 +Bone marrow يطلع هذه اللي هي الـ Normoblast اللي + +267 +00:20:28,340 --> 00:20:31,240 +هي الـ Nucleated RBCs على الـ Peripheral Blood + +268 +00:20:31,240 --> 00:20:36,160 +عشان فيه حاجة مهسة إلها فبالتالي هنلاقي فيه ارتفاع + +269 +00:20:36,160 --> 00:20:40,330 +في الـ Nucleated RBCs هذه الشيءفي الـ «Blood» فيلم + +270 +00:20:40,330 --> 00:20:44,530 +العادي إذن ممكن نشوف «Nucleated RBC» أو نشوف + +271 +00:20:44,530 --> 00:20:48,150 +«Polychromatic Cell» أو «Polychromagia» فاكرين إيش + +272 +00:20:48,150 --> 00:20:52,570 +يعني Polychromagia؟ فاكرين لما حكينا + +273 +00:20:52,570 --> 00:20:57,190 +«Reticulocyte» + +274 +00:20:57,190 --> 00:21:01,270 +يعني خليني نكمل السلسلة اللي قلناها عشان نشبك + +275 +00:21:01,270 --> 00:21:04,010 +الكلام ببعضه فلقيت إحنا قلنا فينا تلت مراحل + +276 +00:21:04,010 --> 00:21:07,850 +«Normal» و «Blast»بعد التلات مراحل هدول بتيجي عند + +277 +00:21:07,850 --> 00:21:13,230 +الـ reticulocyte صح؟ اللي هي الخلية الشبكية اللي + +278 +00:21:13,230 --> 00:21:20,370 +فيها بقايا من الـ RNA reticulocyte هذه عادة عمرها + +279 +00:21:20,370 --> 00:21:25,370 +كله على بعض 72 يوم عفوا + +280 +00:21:25,370 --> 00:21:30,880 +عفوا sorry 72 ساعةهدول 72 ساعة اللي هم تلت أيام + +281 +00:21:30,880 --> 00:21:33,880 +بتقضي منهم يومين في الـ bone marrow واليوم الأخير + +282 +00:21:33,880 --> 00:21:36,900 +بتقضي في ال peripheral blood فأنا في الوضع الطبيعي + +283 +00:21:36,900 --> 00:21:39,280 +بشوف عدد قليل من ال reticulocyte في ال peripheral + +284 +00:21:39,280 --> 00:21:42,920 +blood وقدرناه إذا كنتوا فاكدين 1% تقريبا من نص إلى + +285 +00:21:42,920 --> 00:21:48,760 +1.5% في ال normal صحيح؟ لكن في ال stress أو تحت + +286 +00:21:48,760 --> 00:21:53,780 +ضغط معين هتبلش ال reticulocyteمجرد ما تتكون، تطلع، + +287 +00:21:53,780 --> 00:21:57,500 +يعني مش هتقض يومين في الـ «بون مارو» و بعدين اتكمل + +288 +00:21:57,500 --> 00:22:01,140 +في الـ «بريفرال بلد»، لأ، هتطلع مباشرة من الـ «بون + +289 +00:22:01,140 --> 00:22:04,580 +مارو» و اتطول في الـ «بريفرال بلد»، فهتبلش تتراكم + +290 +00:22:04,580 --> 00:22:09,380 +تاعت اليوم و تاعت اول امبارح، حتى كمية الـ + +291 +00:22:09,380 --> 00:22:13,500 +reticulocyte بلش تتزيد كتير في الـ «بريفرال بلد» + +292 +00:22:13,500 --> 00:22:16,480 +الـ reticulocyte طبعا أنا في الـ blood film العادي + +293 +00:22:17,420 --> 00:22:21,020 +يعني ما بعدها من الـ Blood Film العادى إذا كنتوا + +294 +00:22:21,020 --> 00:22:23,840 +فاكرين كان لها صبغة خاصة اسمها Supravitalistin + +295 +00:22:23,840 --> 00:22:27,540 +تصبغ الخلية و هي حية لكن في الـ Blood Film العادى + +296 +00:22:27,540 --> 00:22:31,560 +طبعا احنا عارفين الـ RBCs دولها Pink هي مع الـ + +297 +00:22:31,560 --> 00:22:36,910 +Pink بتعطي شوية زرقة فبسميها Polychromagiaاللون + +298 +00:22:36,910 --> 00:22:40,130 +الأزرق معين هذا يعني أنا كل الكلام اللي قلته عشان + +299 +00:22:40,130 --> 00:22:43,570 +أذكركم بإيش هي الـ Polychromagia Polychromagia هي + +300 +00:22:43,570 --> 00:22:48,070 +الـ reticular قلاية RBCs هي عبارة أصلا عن + +301 +00:22:48,070 --> 00:22:51,690 +reticulocyte لسه immature RBCs موجودة في الـ + +302 +00:22:51,690 --> 00:22:55,430 +peripheral blood و بتظهر باللون ال pink المطعم أو + +303 +00:22:55,430 --> 00:23:00,690 +الملون باللون الأزرق الخفيف و تتراكم إذن هذه + +304 +00:23:00,690 --> 00:23:05,880 +وجودها بكمية كبيرة مؤشر من مؤشراتالـ Accelerated + +305 +00:23:05,880 --> 00:23:10,680 +Erythropoiesis تمام؟ أو Erythroid Hyperepalgia + +306 +00:23:10,680 --> 00:23:19,480 +تفضيخ + +307 +00:23:19,480 --> 00:23:24,320 +للكلام اللي حكيناه توي أو شرحناه بذكركم هاي الـ + +308 +00:23:24,320 --> 00:23:27,800 +Maturation Series بتاعة ال RVCs هاي هنا الـ + +309 +00:23:27,800 --> 00:23:33,560 +Normoblast التلاتةتلت مراحل لانورموبلاست هيهم بعد + +310 +00:23:33,560 --> 00:23:36,340 +هيك بتجين ال reticulocyte لغاية هنا هذا كله في ال + +311 +00:23:36,340 --> 00:23:39,220 +bone marrow ال reticulocyte بعد يومين من تصنيعها + +312 +00:23:39,220 --> 00:23:42,420 +بتطلع على ال peripheral blood و بتبين باللون اللي + +313 +00:23:42,420 --> 00:23:47,660 +هو الأحمر او الزهري المائل للزرافة هنا هذا الرسمة + +314 +00:23:47,660 --> 00:23:50,720 +بيذكرني او هذه الشريحة بيذكرني فيها في اماكن تصنيع + +315 +00:23:50,720 --> 00:23:55,130 +ال RBCsبقولك لو صار ضغط زيادة على البون مروء + +316 +00:23:55,130 --> 00:23:59,050 +والبون مروء مش قادر يطلع الدم يعني كمية ال blood + +317 +00:23:59,050 --> 00:24:03,510 +اللي لازمة ممكن يرجع يصنع ال blood extra-medullary + +318 +00:24:03,510 --> 00:24:05,750 +احنا عارفين أنه في الـ Adult ميدلاري في الـ Flat + +319 +00:24:05,750 --> 00:24:09,270 +bone في الـ Red marrow في العظام في الأماكن + +320 +00:24:09,270 --> 00:24:12,570 +المحددة في البون مروي اللي هو Red بيصير تصنيع ال + +321 +00:24:12,570 --> 00:24:16,850 +RBC في البون مروي لكن لو صار ضغط و هذا ماقدر يقوم + +322 +00:24:16,850 --> 00:24:20,940 +بالواجب بالشكل الكافيهيرجع التصنيع extra-medullary + +323 +00:24:20,940 --> 00:24:24,400 +يعني هيصير برضه ترجع الـ liver و الـ spleen يتصنع + +324 +00:24:24,400 --> 00:24:27,340 +طبعاً مافيش يوكساك عشان يصنع هو هنا بقولك في + +325 +00:24:27,340 --> 00:24:30,100 +الحياة الجنينية كيف ممكن يكون باليوكساك و في الـ + +326 +00:24:30,100 --> 00:24:32,000 +liver و بالـ spleen بعدين بيصير في الـ bone marrow + +327 +00:24:32,000 --> 00:24:37,600 +لكن ممكن أنه يصير في ال liver و في الـ spine حتى + +328 +00:24:37,600 --> 00:24:40,660 +في الـ adult إذا الجسم بتاعه حاول يصنع من هذا + +329 +00:24:40,660 --> 00:24:44,360 +الجسم قدرة الجسم أنه يعمل adaptation مع الانيميا + +330 +00:24:44,360 --> 00:24:50,010 +يعني بتشوفي واحدة بتقولك أنا دمي سبعةوأنا طول عمري + +331 +00:24:50,010 --> 00:24:53,930 +دم سبعة أنا شوفت واحدة وماشية وعادي وبتشتغل وموظفة + +332 +00:24:53,930 --> 00:24:56,850 +وبتقولك أنا دم سبعة ومنيح لما بيكون سبعة وممكن + +333 +00:24:56,850 --> 00:24:59,690 +يكون ستة وممكن يكون أقل من هاد ولو بتنقليش تم + +334 +00:24:59,690 --> 00:25:03,410 +تقولي لأ أنا خلاص متعودة على هاد هادي صار عندها + +335 +00:25:03,410 --> 00:25:07,150 +adaptation صار عندها تأقلم على هذا الوضع على وضع + +336 +00:25:07,150 --> 00:25:12,250 +الانيميا هادى طبعا هذا بيعتمد على عدة عوامل ال age + +337 +00:25:13,440 --> 00:25:18,100 +والحالة المرضية يعني إيش المرض المصاحب لحالة + +338 +00:25:18,100 --> 00:25:23,200 +الانيميا هذه طبعا ال age كل ما كان العمر أصغر كل + +339 +00:25:23,200 --> 00:25:26,240 +ما كان ال adaptation كل ما كان عند الإنسان قدرة + +340 +00:25:26,240 --> 00:25:29,480 +على ال adaptation أكتر شغلة تانية اللي هي ال + +341 +00:25:29,480 --> 00:25:33,580 +cardio pulmonary function طبعا البنات لو صار + +342 +00:25:33,580 --> 00:25:39,500 +انيميا عند الشخص هيصير overload على ال heart ليش؟ + +343 +00:25:39,500 --> 00:25:43,200 +لأن القلب وظيفته يضخ الدم ويوصل ال oxygenهلقيت لما + +344 +00:25:43,200 --> 00:25:47,900 +الانسجار يكون فيها Hypoxia حيصير القلب يضاعف + +345 +00:25:47,900 --> 00:25:53,380 +مجهوده علشان يوصل Oxygen أكتر للانسجار فإذا كان + +346 +00:25:53,380 --> 00:25:56,880 +القلب والرئتين بتحملوا الكلام هذا السؤال هل هما + +347 +00:25:56,880 --> 00:26:00,600 +بتحملوا ولا في مشكلة أصلا ومع الأنيميا زادت أو + +348 +00:26:00,600 --> 00:26:05,600 +بينت أو انكشفت فبالتالي وظيفة القلب والرئتين مهمة + +349 +00:26:05,600 --> 00:26:12,500 +في موضوع ال adaptation مع الأنيميا شغل تانيةRate + +350 +00:26:12,500 --> 00:26:17,000 +at which anemia develops يعني الأنيميا هادى هل + +351 +00:26:17,000 --> 00:26:20,980 +حصلت فجأة يعني أحسن المثال الشخص هذا أصيب بحادث + +352 +00:26:20,980 --> 00:26:25,840 +ونزف كمية كبيرة من الدم هنا زي بيصير لسه الـ + +353 +00:26:25,840 --> 00:26:29,880 +Bulmar وبدو وقت لما يستوعب الموضوع لكن واحد عنده + +354 +00:26:29,880 --> 00:26:33,380 +نزيف داخلي مثلا لسبب من الأسباب ممكن نزيف بسيط، + +355 +00:26:33,380 --> 00:26:37,140 +نزيف لسه، نزيف مش عارفش وهذا يعني من وقت طويل + +356 +00:26:37,140 --> 00:26:41,960 +وشوية شوية بيصير بشكل chronicطبعا هنا الـ bone + +357 +00:26:41,960 --> 00:26:46,500 +marrow هيبدأ يتعود ويأقلم حاله أنه يعوض هذا الخلل + +358 +00:26:46,500 --> 00:26:53,080 +بطريقة منظمة على خلاف اللي بفقد كميات كبيرة من + +359 +00:26:53,080 --> 00:26:56,520 +الذنب مرة واحدة أنا قلت يعني فقد الذنب كمثال + +360 +00:26:56,940 --> 00:26:59,300 +والانيميا نفس الأشياء يعني أي نوع من أنواع + +361 +00:26:59,300 --> 00:27:02,740 +الانيميا إذا كانت الانيميا بتتطور بطيئا بتعود + +362 +00:27:02,740 --> 00:27:07,500 +عليها الجسم لكن إذا كانت يعني تتكونت فجأة لسبب + +363 +00:27:07,500 --> 00:27:13,060 +مفاجئ لأ الجسم بيكون التعود عليها مش سهل و مش بسيط + +364 +00:27:13,060 --> 00:27:17,080 +ال + +365 +00:27:17,080 --> 00:27:22,460 +symptoms العامة للانيميا أو للـ Hypoxia طبعا هي + +366 +00:27:22,460 --> 00:27:27,410 +أعراض نقص الأكسجين اللي بيوصل للأنسجةبشكل عام، + +367 +00:27:27,410 --> 00:27:32,370 +fatigue، faintness، يعني إرهاق عام لأن العضلات ما + +368 +00:27:32,370 --> 00:27:37,070 +بوصل لها أكسوجين كافي عشان تشتغل كويس، شحوب، ضعف + +369 +00:27:37,070 --> 00:27:42,810 +عام، دوخة، صداع، poor exercise tolerance، لو ماشي + +370 +00:27:42,810 --> 00:27:45,650 +شوية طلع درج بسيريال، هاتوا بتعبوا، بتعرقوا، + +371 +00:27:45,650 --> 00:27:50,610 +مابقدرش يتحملleg cramps تقلصات في الرجلين في عضلات + +372 +00:27:50,610 --> 00:27:55,090 +الرجلين ليش؟ لأن الرجلين مش قادرين يعني يعني + +373 +00:27:55,090 --> 00:27:58,210 +العضلات مش واصلها أكسوجين كفاية عشان تشتغل + +374 +00:27:58,210 --> 00:28:05,670 +فبالتالي ممكن يصير فيها تشنجات أو تقلصات في + +375 +00:28:05,670 --> 00:28:11,170 +عندنا في بعض الأحيان بعض ال signs بتكون general و + +376 +00:28:11,170 --> 00:28:15,170 +بعضها بتكون specific يعني عندنا general signs زي + +377 +00:28:15,170 --> 00:28:19,270 +شحوبالشحوب هذا عادةً أي واحد Hemoglobinه أقل من 9 + +378 +00:28:19,270 --> 00:28:23,930 +هتلاقي Baylor of mucous membrane هتلاقي كل فيه + +379 +00:28:23,930 --> 00:28:27,950 +شحوب عنده يعني لو شفنا جفن العين من جوا هنلاقي فيه + +380 +00:28:27,950 --> 00:28:32,530 +لان شاحب كتير فاتح كتير مثلا والوجه بشكل عام + +381 +00:28:32,530 --> 00:28:36,510 +بتحسيه شاحب الصداعي الدوخة هذه علامات عامة للأنميا + +382 +00:28:36,510 --> 00:28:42,190 +لكن في عندي أشياء خاصة ممكن تدلل على نوع الأنميا + +383 +00:28:42,190 --> 00:28:46,950 +زي مثلاالصفار اللي زي الـ Giandes اليرقان Giandes + +384 +00:28:46,950 --> 00:28:50,450 +كان بسبب ارتفاع البليروبين طب ماهو ارتفاع + +385 +00:28:50,450 --> 00:28:53,710 +البليروبين؟ بليروبين ارتفاع يعني فيه Hemoglobin + +386 +00:28:53,710 --> 00:28:58,370 +اتكسر يعني فيه تكسير يعني فيه Hemolytic Anemia إذن + +387 +00:28:58,370 --> 00:29:01,430 +وجود Giandes بقول إنه فيه Hemolytic Anemia بس إيش + +388 +00:29:01,430 --> 00:29:03,750 +نوع الـ Hemolytic Anemia ما بيقولّي بيعطيني + +389 +00:29:03,750 --> 00:29:08,230 +indication على ال category تاعت الأنميا شغل تانية + +390 +00:29:08,230 --> 00:29:12,720 +Leg Ulcersأحياناً بيكون فيه تقرحات في الرجلين أو + +391 +00:29:12,720 --> 00:29:16,920 +في أماكن معينة من الجسم هذه عادةً بتكون من الـ + +392 +00:29:16,920 --> 00:29:19,620 +Sickle Cell Anemia لأن الـ Sickle Cells ممكن تعمل + +393 +00:29:19,620 --> 00:29:23,720 +تسديد للأوعية الدموية الدقيقة و تبدأ الأوعية هذه + +394 +00:29:23,720 --> 00:29:28,100 +لما تسدد ما يوصلها أكسجين بشكل كافي فتبدأ تتطور + +395 +00:29:28,100 --> 00:29:34,620 +الشغل لمراحل Microsis أو مواد في الأنسجة و Ulcers + +396 +00:29:34,620 --> 00:29:35,340 +and so on + +397 +00:29:38,860 --> 00:29:42,820 +طيب نيجي للـ diagnosis of anemia انا لما بدي اشخص + +398 +00:29:42,820 --> 00:29:46,980 +الانيميا قبل ما اعمل اي diagnosis للانيميا لازم + +399 +00:29:46,980 --> 00:29:56,560 +انتبه لاج six geographical location العمر الجنس + +400 +00:29:56,560 --> 00:30:02,920 +المكان الجغرافي وارتفاعه عن سطح البحر دلوقت بدنا + +401 +00:30:02,920 --> 00:30:06,850 +نشوف كيف بدنا نعمل diagnosis للانيمياclinical + +402 +00:30:06,850 --> 00:30:11,410 +diagnosis of anemia الآن تشخيص الانيميا تلت مراحل + +403 +00:30:11,410 --> 00:30:15,310 +رئيسية ناخد فيها ال patient history و physical + +404 +00:30:15,310 --> 00:30:18,270 +examination و ال lab investigations هناخدهم هيك + +405 +00:30:18,270 --> 00:30:22,170 +على السريع واحدة واحدة بداية ال patient history + +406 +00:30:22,170 --> 00:30:27,350 +بدنا نشوف تعادات الغذائية للمريض هل هو من النوع + +407 +00:30:27,350 --> 00:30:31,430 +اللي بيهتم بالغذاء المتكامل الصحي اللي فيه ال + +408 +00:30:31,430 --> 00:30:35,970 +vitamins اللي فيه العناصر الغذائية الرئيسيةولّا + +409 +00:30:35,970 --> 00:30:39,190 +معتمد على الواجبات السريعة الـ junk foods والأشياء + +410 +00:30:39,190 --> 00:30:42,850 +اللي زي هيك طبعا هذه بـ يعني مافيش فيها عناصر + +411 +00:30:42,850 --> 00:30:46,890 +غذائية ممكن تأثر على تعمل أنميا Medications هل + +412 +00:30:46,890 --> 00:30:50,450 +بياخد أدوية معينة؟ ممكن بعض الأدوية تأتي بمردود + +413 +00:30:50,450 --> 00:30:53,710 +سلبي على تصنيع الـ hemoglobin وعلى قدرة الـ bone + +414 +00:30:53,710 --> 00:30:57,750 +marrow وعلى إنتاج الخلايا هل تعرض إلى بعض ال + +415 +00:30:57,750 --> 00:31:01,250 +chemicals مثلا أخد chemicals أخد chemotherapy أو + +416 +00:31:01,250 --> 00:31:06,730 +تعرض لبعض ال toxins؟description and duration of + +417 +00:31:06,730 --> 00:31:10,330 +symptoms يعني الآن أنت من وقتيش عندك الأعراض هذه + +418 +00:31:10,330 --> 00:31:15,090 +من زمان مثلا طول عمري بعاني من الأعراض هذه من شهر + +419 +00:31:15,090 --> 00:31:18,430 +من أسبوع كل هذا إله دلائل مثلا أخدت علاج وبعد + +420 +00:31:18,430 --> 00:31:21,110 +العلاج هذا بدت معايا الأعراض كلها هذه الـhistory + +421 +00:31:21,110 --> 00:31:26,050 +مهمة عشان الدكتور يكوّن في دماغه صورة متكاملة عن + +422 +00:31:26,050 --> 00:31:29,730 +حالة ال patient هذا ويعرف إيش الخطوة التالية يعني + +423 +00:31:29,730 --> 00:31:34,670 +إيش الخطوة التي تتلي خطوة الـhistoryاشو يطلبله + +424 +00:31:34,670 --> 00:31:40,670 +تحليل and so on tiredness يعني هل هو short history + +425 +00:31:40,670 --> 00:31:43,970 +برضه اش بياخد فيه muscle fatigue or weakness هل + +426 +00:31:43,970 --> 00:31:48,570 +بتعاني من muscle fatigue او weakness headache او + +427 +00:31:48,570 --> 00:31:55,620 +اللي هي الدزنس الدوار او الزغللة dyspneaاللي هي + +428 +00:31:55,620 --> 00:31:58,940 +تسميها صعوبة في التنفس يعني هل مثلا عندك ضيقة نفس + +429 +00:31:58,940 --> 00:32:02,620 +بتحس أنه لما بتيجي تطلع درج لما هدا بتضايق بتزيد + +430 +00:32:02,620 --> 00:32:06,240 +ضربات قلبك ومثلا بيصير عندك صعوبة في التنفس، هل + +431 +00:32:06,240 --> 00:32:09,660 +عندك مشاكل في الـ gastrointestinal tract، overt + +432 +00:32:09,660 --> 00:32:13,100 +signs of blood loss such as هيماتوريا، حاجات واضحة + +433 +00:32:13,100 --> 00:32:16,240 +زي الهيماتوريا أو black spool، كل هذه دلائل على + +434 +00:32:16,240 --> 00:32:18,580 +إنه في فاقد للدم، في blood loss + +435 +00:32:21,670 --> 00:32:26,310 +طيب نيجي ل الـ Physical Examination برضه هذا يعني + +436 +00:32:26,310 --> 00:32:31,190 +الدكتور اللي .. يعني شغل .. شغل الطبيب مش شغلنا + +437 +00:32:31,190 --> 00:32:35,370 +احنا أول حاجة بشكل عام ممكن يلاقي عنده Hepato + +438 +00:32:35,370 --> 00:32:38,990 +-splenomegalate ليش؟ لأن زي ما قلنا ال liver و ال + +439 +00:32:38,990 --> 00:32:42,350 +spleen بيحسيروا بدهم يتنشطوا من دوره جديد extra + +440 +00:32:42,350 --> 00:32:46,050 +medullary hematopoiesis ويصنعوا دم بيدهم ي sendوا + +441 +00:32:46,050 --> 00:32:51,010 +ال bone marrow عشان يغطوا العجزHeart abnormalities + +442 +00:32:51,010 --> 00:32:53,390 +مشاكل في الـ heart لأن الـ heart هيصير عليه + +443 +00:32:53,390 --> 00:32:56,730 +overload هيصير يشتغل بزيادة عشان يوصل الأكسجين + +444 +00:32:56,730 --> 00:33:01,770 +أكتر للأنسجة skin baler شحوب في الجلد أو في البشرة + +445 +00:33:01,770 --> 00:33:09,350 +بشكل أكبر طيب specific finding يعني هذه أشياء خاصة + +446 +00:33:09,350 --> 00:33:14,710 +ببعض الحالات المرضية فلقيت مثلا في حالة الـ + +447 +00:33:14,710 --> 00:33:20,010 +vitamin B12 deficiencyهتلاقي signs of malnutrition + +448 +00:33:20,010 --> 00:33:24,370 +هنلاقي عند الشخص أعراض سوء التغذية بالإضافة إلى + +449 +00:33:24,370 --> 00:33:29,130 +بعض الأعراض اللي لها علاقة بالأعصاب يعني ممكن + +450 +00:33:29,130 --> 00:33:33,290 +تلاقي مثلا عندها الرجبة في إيديها عندها بعض + +451 +00:33:33,290 --> 00:33:39,410 +التشنجات البسيطة في أصابعها هذه ممكن خدل هذه عادة + +452 +00:33:39,410 --> 00:33:43,340 +بقول الدكتور أحتمال يكون عندها B12 deficiencyهلقد + +453 +00:33:43,340 --> 00:33:47,740 +في الـ iron deficiency مثلا بنلاقي severe pallor + +454 +00:33:47,740 --> 00:33:52,140 +ال tongue بيكون smooth، smooth tongue اللسان and + +455 +00:33:52,140 --> 00:34:00,260 +esophageal webs بتلاقي زي طبقات أو طب بتكون مغطية + +456 +00:34:00,260 --> 00:34:05,430 +ال esophagusin hematologic anemia عفوًا hemolytic + +457 +00:34:05,430 --> 00:34:08,930 +anemia طبعًا عادة في الـ hemolytic anemia ممكن + +458 +00:34:08,930 --> 00:34:12,410 +ألاقي joints واضح صفار واضح نتيجة وجود باليروبين + +459 +00:34:12,410 --> 00:34:17,790 +وتكثير لل RBCs نتيجي ثالثًا في ال diagnosis + +460 +00:34:17,790 --> 00:34:21,990 +للأنيميا اللي هو ال lab diagnosis اللي هو شغلنا + +461 +00:34:21,990 --> 00:34:26,870 +أول حاجة طبعًا بطلبها الدكتور اللي هو ال CBC CBC + +462 +00:34:26,870 --> 00:34:33,210 +ينطلق منه للأشياء التالية إذا بطلب CBCبطلب blood + +463 +00:34:33,210 --> 00:34:38,530 +smear عشان يعمل evaluation للـ boiculocytosis يشوف + +464 +00:34:38,530 --> 00:34:41,430 +إذا فيها أنزوسيتوزيز إذا فيها ممكن يطلب bone + +465 +00:34:41,430 --> 00:34:45,430 +marrow biopsy bone marrow biopsy ممكن نشوف من + +466 +00:34:45,430 --> 00:34:49,270 +خلالها شوف يا بنات ال bone marrow biopsy يعني + +467 +00:34:49,270 --> 00:34:52,630 +خلينا نكون واقعيين مش كتير بتنطلب يعني بتنطلبش + +468 +00:34:52,630 --> 00:34:56,630 +للأنيميا بتنطلب بس في حالات زي مثلا يعني حالات + +469 +00:34:56,630 --> 00:35:01,710 +فعلا هم مش قادرين يشخصوها حالات ال aplastic anemia + +470 +00:35:01,970 --> 00:35:05,610 +مش يعني مريض الانيميا العادي مابناخدش منه bone + +471 +00:35:05,610 --> 00:35:08,670 +marrow biopsy يعني خلينا نكون في واقعيين و في صورة + +472 +00:35:08,670 --> 00:35:12,890 +الوضع يعني لكن انا بقولك ال bone marrow biopsy لو + +473 +00:35:12,890 --> 00:35:16,130 +احنا عملناها ممكن نشوف ال maturation of RBCs and + +474 +00:35:16,130 --> 00:35:19,820 +YPCs seriesنشوف نسبة الـ Myeloid للـ Erythroid + +475 +00:35:19,820 --> 00:35:25,520 +abundance of iron stars كمية الـ iron stars مثلاً + +476 +00:35:25,520 --> 00:35:28,580 +هل هي قليلة، هل هي كتيرة، طبعاً في الـ iron + +477 +00:35:28,580 --> 00:35:30,980 +deficiency بيكون قليلة في الـ Sodroplastic anemia + +478 +00:35:30,980 --> 00:35:35,820 +بتزيد and so on presence or absence of granuloma + +479 +00:35:35,820 --> 00:35:40,520 +or tumor cells، يعني هل في مثلاًأثر على تصنيع الدم + +480 +00:35:40,520 --> 00:35:44,280 +وجود خلايا tumor أو cancer أو malignant cells هذه + +481 +00:35:44,280 --> 00:35:48,660 +الخلايا قدت لنقص تصنيع الخلايا الطبيعية Red to + +482 +00:35:48,660 --> 00:35:51,740 +Yellow Ratio طبعا عارفين الـ Red to Yellow Ratio + +483 +00:35:52,020 --> 00:35:54,620 +اللي هي الـ Red bone marrow الـ Active واليالو + +484 +00:35:54,620 --> 00:35:57,800 +اللي هو الـ Inactive فبتشوفوا ال ratio بينه + +485 +00:35:57,800 --> 00:36:01,640 +Presence of megakaryocyte زي ما بقولكم تاني أنه في + +486 +00:36:01,640 --> 00:36:04,600 +الأنميا ما بنطلب bone marrow إلا في بعض الحالات + +487 +00:36:04,600 --> 00:36:07,720 +الصعبة يعني أنا ماباروح أطلب bone marrow عشان أشوف + +488 +00:36:07,720 --> 00:36:11,260 +ال iron stores وانا عندي الحديد في الدم ممكن أشوفه + +489 +00:36:11,260 --> 00:36:13,660 +ال iron و ال total iron binding كبسط زي ما قدنا + +490 +00:36:13,660 --> 00:36:16,900 +نشوفه بس ممكن في ال aplastic anemia في الحالات + +491 +00:36:16,900 --> 00:36:20,200 +اللي يعنيتبقى فعلا أنا شاك كأنه يعني إيش ما أعطي، + +492 +00:36:20,200 --> 00:36:23,280 +إيش ما أعطي، مافيش استجابة وانا شاك كأنه فيه خلل + +493 +00:36:23,280 --> 00:36:25,980 +في البونمارو ممكن يطلبوا بونمارو biopsy أما في + +494 +00:36:25,980 --> 00:36:30,800 +الوضع العادي لأممكن يعملوا Hemoglobin + +495 +00:36:30,800 --> 00:36:34,300 +Electrophoresis طبعا عشان يشوفوا أي أنواع تانية من + +496 +00:36:34,300 --> 00:36:37,900 +الـ Abnormal Hemoglobin زي Hemoglobin S، D، G، + +497 +00:36:37,900 --> 00:36:42,900 +Hemoglobin C كل هذه الأنواع بتظهر الـ Hemoglobin + +498 +00:36:42,900 --> 00:36:45,060 +وBethes طبعا وأنواع الـ Hemoglobin الـ Abnormal + +499 +00:36:45,060 --> 00:36:50,580 +بتظهر في الـ Hemoglobin Electrophoresis ممكن ينطلب + +500 +00:36:50,580 --> 00:36:53,840 +Antiglobulin Testing ممكن ينطلب Osmotic Fragility + +501 +00:36:53,840 --> 00:36:57,710 +Testing ممكن ينطلب Sickle Cell Testممكن ينطلب + +502 +00:36:57,710 --> 00:37:01,250 +Sucrose Test عشان الـ BNH إذا كنت فاكريني يعني كل + +503 +00:37:01,250 --> 00:37:05,190 +الفحصات اللي احنا درسناها في الـ Hematology اللي + +504 +00:37:05,190 --> 00:37:08,450 +لاتش ممكن ينطلب فحص مثلا Hemoglobin A2 ممكن نعمل + +505 +00:37:08,450 --> 00:37:11,830 +Quantitation لـ Hemoglobin F كل هذه الأشياء ممكن + +506 +00:37:11,830 --> 00:37:15,270 +تنطلب ممكن ينطلب Iron Total Iron Binding Capacity + +507 +00:37:15,270 --> 00:37:18,490 +يعني في مجموعة فحصات Kinestry ممكن تنطلب في بعض + +508 +00:37:18,490 --> 00:37:22,350 +الأحيان Folic Acid Folate Vitamin B12 كله هاد عشان + +509 +00:37:22,350 --> 00:37:25,870 +بالنهاية نعرف إيش النوع الصحيح للأداميا + diff --git a/PL9fwy3NUQKwZMFBrUcRiLUW660ZZJ9vip/re26D5Gw16M_raw.json 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"probability": 0.98125}, {"start": 131.4, "end": 132.46, "word": " أسباب", "probability": 0.9921875}, {"start": 132.46, "end": 133.4, "word": " الانيميا", "probability": 0.6602783203125}, {"start": 133.4, "end": 135.2, "word": " ال", "probability": 0.9599609375}, {"start": 135.2, "end": 136.72, "word": " clinical", "probability": 0.132568359375}, {"start": 136.72, "end": 137.62, "word": " significance", "probability": 0.97021484375}, {"start": 137.62, "end": 138.34, "word": " لال", "probability": 0.655517578125}, {"start": 138.34, "end": 138.86, "word": " categories", "probability": 0.94921875}, {"start": 138.86, "end": 139.56, "word": " المختلفة", "probability": 0.9906005859375}, {"start": 139.56, "end": 139.8, "word": " برضه", "probability": 0.9451497395833334}, {"start": 139.8, "end": 139.94, "word": " من", "probability": 0.90283203125}, {"start": 139.94, "end": 140.46, "word": " الانيميا", "probability": 0.9508056640625}, {"start": 140.46, "end": 141.82, "word": " راح", "probability": 0.962890625}, {"start": 141.82, "end": 142.34, "word": " نعرف", "probability": 0.99609375}, {"start": 142.34, "end": 143.2, "word": " انصنف", "probability": 0.78387451171875}, {"start": 143.2, "end": 143.6, "word": " أنواع", "probability": 0.97607421875}, {"start": 143.6, "end": 144.06, "word": " الانيميا", "probability": 0.949462890625}, {"start": 144.06, "end": 144.74, "word": " المختلفة", "probability": 0.9971923828125}], "temperature": 1.0}, {"id": 6, "seek": 17361, "start": 145.61, "end": 173.61, "text": "نقدر في النهاية نقول هذه مثلا microcytic anemia هذه macrocytic anemia هذه normocytic مثلا normochromic anemia فنقدر نصنف الانيميا حسب قراتي للنتائج لأحد الأنواع الرئيسية فيها يكون عندنا القدرة على أننا نناقش نتائج النتائج اللي بحصل عليها في المختبر", "tokens": [1863, 28543, 2288, 8978, 28239, 11296, 10632, 8717, 39648, 29538, 50113, 15040, 4532, 1344, 40907, 364, 14058, 29538, 18887, 1344, 40907, 364, 14058, 29538, 2026, 31078, 40907, 50113, 15040, 2026, 8997, 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من الانيميا يعني مثلا شوف ال CPC أول حاجة بدي أطلع مثلا على ال Hemoglobin Hemoglobin واطي إذا انانيميا طيب إيش نوعها مثلا هي microcytic hypochromic and so on و أسير أربط النتائج هادة بعضها", "tokens": [2407, 10721, 28543, 2288, 14739, 12984, 3555, 29538, 28239, 2655, 16373, 7435, 5296, 10721, 24401, 2423, 10479, 9154, 2423, 7649, 32640, 25528, 37495, 22653, 50113, 15040, 13412, 38688, 2423, 383, 12986, 5551, 12610, 11331, 26108, 3660, 4724, 16254, 5551, 9566, 1211, 3615, 50113, 15040, 15844, 2423, 18568, 45841, 13496, 18568, 45841, 13496, 4032, 41193, 1829, 11933, 15730, 16472, 7649, 32640, 25528, 23032, 1829, 3555, 11933, 1829, 8592, 8717, 45367, 11296, 50113, 15040, 39896, 4532, 1344, 40907, 2477, 2259, 339, 4397, 299, 293, 370, 322, 4032, 5551, 3794, 13546, 5551, 25513, 9566, 28239, 2655, 16373, 7435, 8032, 18513, 3660, 45030, 11242, 11296], "avg_logprob": -0.21522672255249584, "compression_ratio": 1.5701754385964912, "no_speech_prob": 3.24249267578125e-05, "words": [{"start": 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"probability": 0.5831298828125}, {"start": 185.5, "end": 186.0, "word": " انانيميا", "probability": 0.74951171875}, {"start": 186.0, "end": 186.42, "word": " طيب", "probability": 0.9375}, {"start": 186.42, "end": 186.72, "word": " إيش", "probability": 0.8603515625}, {"start": 186.72, "end": 187.2, "word": " نوعها", "probability": 0.9921875}, {"start": 187.2, "end": 187.58, "word": " مثلا", "probability": 0.6849365234375}, {"start": 187.58, "end": 187.78, "word": " هي", "probability": 0.64794921875}, {"start": 187.78, "end": 189.16, "word": " microcytic", "probability": 0.7215169270833334}, {"start": 189.16, "end": 189.8, "word": " hypochromic", "probability": 0.856689453125}, {"start": 189.8, "end": 190.0, "word": " and", "probability": 0.62060546875}, {"start": 190.0, "end": 190.18, "word": " so", "probability": 0.9208984375}, {"start": 190.18, "end": 190.36, "word": " on", "probability": 0.953125}, {"start": 190.36, "end": 190.82, "word": " و", "probability": 0.63037109375}, 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{"start": 555.56, "end": 555.98, "word": " واضح", "probability": 0.97265625}, {"start": 555.98, "end": 556.22, "word": " احنا", "probability": 0.78857421875}, {"start": 556.22, "end": 556.34, "word": " اللي", "probability": 0.953369140625}, {"start": 556.34, "end": 556.96, "word": " بتهمنا", "probability": 0.94091796875}, {"start": 556.96, "end": 557.22, "word": " اللي", "probability": 0.967041015625}, {"start": 557.22, "end": 557.38, "word": " هي", "probability": 0.8974609375}, {"start": 557.38, "end": 557.6, "word": " الـ", "probability": 0.90625}, {"start": 557.6, "end": 557.78, "word": " True", "probability": 0.90283203125}, {"start": 557.78, "end": 558.56, "word": " Anemia", "probability": 0.977783203125}, {"start": 558.56, "end": 563.78, "word": " طيب،", "probability": 0.78643798828125}, {"start": 563.78, "end": 563.98, "word": " في", "probability": 0.89306640625}, {"start": 563.98, "end": 564.24, "word": " عندنا", "probability": 0.64404296875}, {"start": 564.24, "end": 564.96, 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0.974853515625}], "temperature": 1.0}, {"id": 22, "seek": 62198, "start": 593.66, "end": 621.98, "text": "و نفس الظروف تقريبا و في نفس البيئة عايشين و ليش انا اعتبرت هذي Normal و هذي Abnormal فنسين قلتلها ان انت كويسة لأن انا طول عمري او اكتر من مرة اتجيب لـ CBC يكون هذا هو ال range الطبيعي لها يعني 11، 11.5، 10.5 هي دمها هيك ايش ما تعمل مش هيزيد عن هيك لكن التانية كان دمها 13 انا عارفة ان قبل هيك عملت ال hemoglobin كان 13 و أجتني", "tokens": [2407, 8717, 36178, 6024, 116, 32887, 5172, 6055, 4587, 16572, 3555, 995, 4032, 8978, 8717, 36178, 2423, 21292, 19986, 3660, 6225, 47302, 8592, 9957, 4032, 32239, 8592, 1975, 8315, 1975, 34268, 26890, 2655, 8032, 8848, 1829, 21277, 4032, 8032, 8848, 1829, 2847, 23157, 6156, 1863, 3794, 9957, 12174, 1211, 2655, 1211, 11296, 16472, 16472, 2655, 9122, 45865, 3794, 3660, 5296, 33456, 1975, 8315, 23032, 12610, 6225, 2304, 16572, 1975, 2407, 1975, 4117, 2655, 2288, 9154, 3714, 25720, 1975, 2655, 7435, 1829, 3555, 5296, 39184, 383, 7869, 7251, 30544, 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{"start": 609.12, "end": 609.96, "word": " 11،", "probability": 0.6048583984375}, {"start": 609.96, "end": 610.42, "word": " 11", "probability": 0.86474609375}, {"start": 610.42, "end": 611.46, "word": ".5،", "probability": 0.7796223958333334}, {"start": 611.46, "end": 611.74, "word": " 10", "probability": 0.89013671875}, {"start": 611.74, "end": 612.1, "word": ".5", "probability": 0.972412109375}, {"start": 612.1, "end": 612.26, "word": " هي", "probability": 0.9091796875}, {"start": 612.26, "end": 612.54, "word": " دمها", "probability": 0.9918619791666666}, {"start": 612.54, "end": 612.82, "word": " هيك", "probability": 0.794677734375}, {"start": 612.82, "end": 613.02, "word": " ايش", "probability": 0.592529296875}, {"start": 613.02, "end": 613.12, "word": " ما", "probability": 0.72412109375}, {"start": 613.12, "end": 613.42, "word": " تعمل", "probability": 0.9708658854166666}, {"start": 613.42, "end": 613.54, "word": " مش", "probability": 0.99365234375}, {"start": 613.54, "end": 613.88, "word": " هيزيد", "probability": 0.8361002604166666}, {"start": 613.88, "end": 614.02, "word": " عن", "probability": 0.9921875}, {"start": 614.02, "end": 614.84, "word": " هيك", "probability": 0.856689453125}, {"start": 614.84, "end": 615.12, "word": " لكن", "probability": 0.9072265625}, {"start": 615.12, "end": 615.8, "word": " التانية", "probability": 0.9700520833333334}, {"start": 615.8, "end": 616.06, "word": " كان", "probability": 0.98046875}, {"start": 616.06, "end": 616.3, "word": " دمها", "probability": 0.9925130208333334}, {"start": 616.3, "end": 616.98, "word": " 13", "probability": 0.96826171875}, {"start": 616.98, "end": 618.12, "word": " انا", "probability": 0.760986328125}, {"start": 618.12, "end": 618.46, "word": " عارفة", "probability": 0.9805908203125}, {"start": 618.46, "end": 618.6, "word": " ان", "probability": 0.68115234375}, {"start": 618.6, "end": 618.86, "word": " قبل", "probability": 0.905029296875}, {"start": 618.86, "end": 619.12, "word": " هيك", "probability": 0.929443359375}, {"start": 619.12, "end": 619.46, "word": " عملت", "probability": 0.9744466145833334}, {"start": 619.46, "end": 619.58, "word": " ال", "probability": 0.98486328125}, {"start": 619.58, "end": 620.3, "word": " hemoglobin", "probability": 0.7579752604166666}, {"start": 620.3, "end": 620.68, "word": " كان", "probability": 0.84619140625}, {"start": 620.68, "end": 621.1, "word": " 13", "probability": 0.9375}, {"start": 621.1, "end": 621.5, "word": " و", "probability": 0.7431640625}, {"start": 621.5, "end": 621.98, "word": " أجتني", "probability": 0.782470703125}], "temperature": 1.0}, {"id": 23, "seek": 62973, "start": 622.55, "end": 629.73, "text": "اليوم بـ 11 بقولها لأ انت hemoglobinك نازل اذا ضروري عشان احكم على انسان انه عنده anemia", "tokens": [6027, 1829, 20498, 4724, 39184, 2975, 4724, 39648, 11296, 5296, 10721, 16472, 2655, 8636, 45841, 13496, 4117, 8717, 31377, 1211, 1975, 15730, 48812, 2288, 13063, 1829, 6225, 8592, 7649, 1975, 5016, 24793, 15844, 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"end": 743.22, "text": "إذن هذه nutritional deficiencies External or internal blood loss فقد الدم على فترات قد يكون فقد الدم acute ويؤدي لهبوط في الدم في الـ hemoglobin وقد يكون chronic إن الإنسان هذا بفقد كميات بسيطة من الدم على فترات زمنية طويلة فبالتالي بينشأ عنها أنميا Increased extraction of RBCs", "tokens": [28814, 8848, 1863, 29538, 34707, 19248, 31294, 48277, 420, 6920, 3390, 4470, 6156, 28543, 32748, 2304, 15844, 6156, 2655, 2288, 9307, 12174, 3215, 7251, 30544, 6156, 28543, 32748, 2304, 24390, 4032, 1829, 33604, 16254, 46740, 3555, 2407, 9566, 8978, 32748, 2304, 8978, 2423, 39184, 8636, 45841, 13496, 4032, 28543, 7251, 30544, 14493, 36145, 33688, 1863, 3794, 7649, 23758, 4724, 5172, 28543, 9122, 2304, 1829, 9307, 4724, 3794, 1829, 9566, 3660, 9154, 32748, 2304, 15844, 6156, 2655, 2288, 9307, 30767, 27842, 10632, 23032, 2407, 26895, 3660, 6156, 3555, 6027, 2655, 6027, 1829, 4724, 9957, 8592, 10721, 18871, 11296, 14739, 2304, 25528, 30367, 1937, 30197, 295, 497, 7869, 82], 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or absence of granuloma or tumor cells، يعني هل في مثلاً", "tokens": [1863, 8592, 38688, 8717, 35457, 3660, 2423, 39184, 1222, 10590, 327, 24976, 39184, 462, 627, 392, 6490, 23391, 295, 6497, 6105, 9122, 2304, 10632, 2423, 39184, 6497, 6105, 50113, 15040, 14111, 8032, 1211, 39896, 12174, 20292, 37977, 12399, 8032, 1211, 39896, 9122, 2655, 48923, 12399, 23032, 3555, 3615, 995, 14111, 8978, 2423, 39184, 6497, 37500, 4724, 1829, 30544, 12174, 20292, 37977, 8978, 2423, 39184, 42059, 340, 564, 2750, 364, 14058, 39894, 11622, 25708, 293, 370, 322, 6814, 420, 17145, 295, 9370, 425, 6440, 420, 22512, 5438, 12399, 37495, 22653, 8032, 1211, 8978, 50113, 15040, 14111], "avg_logprob": -0.2234700578264892, "compression_ratio": 1.5530973451327434, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 2117.56, "end": 2118.02, "word": "نشوف", "probability": 0.888671875}, {"start": 2118.02, "end": 2118.42, "word": " نسبة", "probability": 0.990234375}, {"start": 2118.42, "end": 2118.58, "word": " 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00:00:34,590 +أمراض الدم تقريبابتتقسم لـ Three categories اللي + +7 +00:00:34,590 --> 00:00:39,390 +هي الأنيميا وما يلحق بها لوكيميا وملحقاتها + +8 +00:00:39,390 --> 00:00:43,470 +Coagulation disorders فهتكون هذه المحاور الرئيسية + +9 +00:00:43,470 --> 00:00:50,950 +التلاتة اللي راح نتناولها بهذا الفصل راح ناخد موجز + +10 +00:00:50,950 --> 00:00:56,330 +أو ملخص عن كل حالة من هذه أو كل قسم من هذه الأقسام + +11 +00:00:57,040 --> 00:01:02,760 +على شكل محاضرة وبعد هيك هتكون الجزئية الباقية في + +12 +00:01:02,760 --> 00:01:06,360 +هذا الموضوع راح نكملها على شكل case studies لأنه + +13 +00:01:06,360 --> 00:01:10,500 +أنا اليوم بيهمني مش أني أحفظ إيش تعريف الانيميا أو + +14 +00:01:10,500 --> 00:01:12,540 +إيش تعريفها أو إيش ال pathophysiology تبعها أو إيش + +15 +00:01:12,540 --> 00:01:17,040 +الكلام هذا لأ أنا بيهمني لما أشوف result أعرف + +16 +00:01:17,040 --> 00:01:22,060 +أقرأها وأعرف أربط النتائج هذه مع بعض وأستنتج إيش + +17 +00:01:22,060 --> 00:01:25,380 +الحالة المرضية اللي قد تكون مساحبة لهذا ال result + +18 +00:01:25,790 --> 00:01:29,330 +إيش ملزمني أطلب فحوصات فيما بعد أو إيش ملزمني أدور + +19 +00:01:29,330 --> 00:01:32,370 +على فحوصات عشان أتأكد من الـresults معينة هذا + +20 +00:01:32,370 --> 00:01:36,270 +الكلام بإذن الله كله راح نناقشه مع بعض شويه شويه + +21 +00:01:36,270 --> 00:01:40,390 +أول حاجة هنشرحه بعد هيك هناخد عليه أمثلة تبقية على + +22 +00:01:40,390 --> 00:01:43,470 +شكل حالات مرضية طبعا محاضرتنا هيكون فيها مجموعة من + +23 +00:01:43,470 --> 00:01:48,410 +الأهداف في النهاية راح يكون عندنا القدرة على إنه + +24 +00:01:48,410 --> 00:01:51,950 +نعرف الأنيميا راح نلاقي الأنيميا إلها أكتر من + +25 +00:01:51,950 --> 00:01:56,960 +تعريف ما شاء الله رب العالمين هنشوف مع بعضإيش هي + +26 +00:01:56,960 --> 00:02:00,820 +التعريفات الصحيحة وفي ناس يعني في تعريفات اللي لها + +27 +00:02:00,820 --> 00:02:04,680 +علاقة بالمختبر وفي تعريفات اللي لها علاقة بالأطباء + +28 +00:02:04,680 --> 00:02:09,080 +فهنشوف التعريفات المختلفة اللي لها راح يكون عندنا + +29 +00:02:09,080 --> 00:02:16,720 +القدرة على مناقشة أسباب الانيميا ال clinical + +30 +00:02:16,720 --> 00:02:19,940 +significance لال categories المختلفة برضه من + +31 +00:02:19,940 --> 00:02:24,740 +الانيميا راح نعرف انصنف أنواع الانيميا المختلفة + +32 +00:02:25,610 --> 00:02:30,490 +نقدر في النهاية نقول هذه مثلا microcytic anemia + +33 +00:02:30,490 --> 00:02:33,870 +هذه macrocytic anemia هذه normocytic مثلا + +34 +00:02:33,870 --> 00:02:39,310 +normochromic anemia فنقدر نصنف الانيميا حسب قراتي + +35 +00:02:39,310 --> 00:02:44,910 +للنتائج لأحد الأنواع الرئيسية فيها يكون عندنا + +36 +00:02:44,910 --> 00:02:50,350 +القدرة على أننا نناقش نتائج النتائج اللي بحصل + +37 +00:02:50,350 --> 00:02:58,000 +عليها في المختبروأقدر أنثب هذه النتائج لأحد ال + +38 +00:02:58,000 --> 00:03:01,940 +categories من الانيميا يعني مثلا شوف ال CPC أول + +39 +00:03:01,940 --> 00:03:04,800 +حاجة بدي أطلع مثلا على ال Hemoglobin Hemoglobin + +40 +00:03:04,800 --> 00:03:09,160 +واطي إذا انانيميا طيب إيش نوعها مثلا هي microcytic + +41 +00:03:09,160 --> 00:03:12,120 +hypochromic and so on و أسير أربط النتائج هادة + +42 +00:03:12,120 --> 00:03:15,530 +بعضهاperform basic laboratory test for the + +43 +00:03:15,530 --> 00:03:20,190 +diagnosis of anemia كيف؟ طبعاً هذا الشخصية هذه + +44 +00:03:20,190 --> 00:03:22,830 +الـbasic laboratory test for diagnosis of anemia + +45 +00:03:22,830 --> 00:03:25,990 +طبعاً هذه احنا شغلناها بالتفصيل في مساقع الدم + +46 +00:03:25,990 --> 00:03:28,390 +السريري اللي هي الفصوات الأساسية اللي لازم تشتر في + +47 +00:03:28,390 --> 00:03:30,810 +الانميا ال outlines هيكون بداية عندنا definition + +48 +00:03:30,810 --> 00:03:37,730 +of anemia classification of anemia برضه يعني هيكون + +49 +00:03:37,730 --> 00:03:41,790 +عندنا بعض النقاط هناخدها ال hematologic response + +50 +00:03:41,790 --> 00:03:46,750 +to anemiaSigns of Accelerated Bone Erythropoiesis + +51 +00:03:46,750 --> 00:03:50,730 +إيش بيصير لما البون مار يصير يشغل تحت stress + +52 +00:03:50,730 --> 00:03:54,510 +Physiologic Response to Anemia Methods of + +53 +00:03:54,510 --> 00:03:59,570 +Classification Anemia Diagnosis and Causes أسبابها + +54 +00:03:59,570 --> 00:04:03,970 +وتشخيصها Lab Investigation of Anemia كيف إحنا نشخص + +55 +00:04:03,970 --> 00:04:08,650 +الأنيميا في المختبر؟ هيكون عندنا طبعا أنواع + +56 +00:04:08,650 --> 00:04:14,240 +الأنيميا Microcytic Hypochromicنورموسيتك مثلا + +57 +00:04:14,240 --> 00:04:17,800 +نورموسيتك أنيميا نورموسيتك أنيميا due to + +58 +00:04:17,800 --> 00:04:20,760 +hemoglobin and pathase طبعا كل هذه أشياء راح + +59 +00:04:20,760 --> 00:04:27,100 +ناخدها بإذن الله بالتفصيل طيب + +60 +00:04:27,100 --> 00:04:31,420 +نحاول نعرف الأنيميا مع بعض لو جيت قلتلكم عرفولي + +61 +00:04:31,420 --> 00:04:37,600 +الأنيميا أكيد هتقولولي نقص ال RBCs نقص الهمoglobin + +62 +00:04:37,600 --> 00:04:42,740 +نقص ال hematocrit يعني هي نقصالـ Oxygen-carrying + +63 +00:04:42,740 --> 00:04:47,700 +components of blood بالظبط نقص الـ Oxygen-carrying + +64 +00:04:47,700 --> 00:04:51,140 +components مين هي أهم حاجة بيحمل الأكسجين؟ طبعاً + +65 +00:04:51,140 --> 00:04:54,080 +زي ما انتوا عارفين الـ Hemoglobin فبالتالي + +66 +00:04:54,080 --> 00:04:58,120 +الأناميا is a decrease in the RBCs count + +67 +00:04:58,120 --> 00:05:02,680 +Hemoglobin or Hematocrit طبعاً لو أنا قارنتهم بالـ + +68 +00:05:02,680 --> 00:05:06,200 +Normal Range وانتوا عارفين ان احنا لما بنقارن بـ + +69 +00:05:06,200 --> 00:05:11,680 +Rangeكل فئة عمرية لها range وبرضه related to sex + +70 +00:05:11,680 --> 00:05:15,680 +المال يختلف عن الفيمال فبالتالي لما أنا بدي أقارن + +71 +00:05:15,680 --> 00:05:22,720 +أقارن بال range المخصص لهذه الفئة العمرية وهذا ال + +72 +00:05:22,720 --> 00:05:28,440 +gender طيب نيجي لتعريف + +73 +00:05:28,440 --> 00:05:32,420 +أو تفريق ما بين شغلتان true anemia and pseudo + +74 +00:05:32,420 --> 00:05:37,830 +anemia لـ true anemiaبتبقى عندى الـ blood + +75 +00:05:37,830 --> 00:05:44,670 +components قليلة تمام و الـ plasma volume normal + +76 +00:05:44,670 --> 00:05:51,310 +decreased RBCs mass and normal plasma volume كويس؟ + +77 +00:05:51,310 --> 00:05:55,870 +يعني مين اللي بنقص عندى؟ الـ RBCs السودوانيميا + +78 +00:05:55,870 --> 00:06:00,890 +السودوانيميا مختلفة فإن كمية الـ RBCs مابتكونش + +79 +00:06:00,890 --> 00:06:06,550 +قليلة لكن بصيرلها dilutionيعني بيصير تخفيف للدم + +80 +00:06:06,550 --> 00:06:12,270 +فبالتالي نظرا لأن ال blood اتخفف زادت كمية ال + +81 +00:06:12,270 --> 00:06:16,730 +fluids اللي فيه كل مقاجي أقيس حاجة أو أقرأها هلاقي + +82 +00:06:16,730 --> 00:06:20,670 +تركيزها قليل لأنه صار لها فعليا dilution بس هي ما + +83 +00:06:20,670 --> 00:06:25,290 +ناقص تصنيعها هي المشكلة أنه حصل dilution وهذه حاجة + +84 +00:06:25,290 --> 00:06:29,310 +عادة بتكون مؤقتة بنسميها pseudoanemia أو + +85 +00:06:29,310 --> 00:06:33,990 +dilutional anemia normal RBCs massand increase + +86 +00:06:33,990 --> 00:06:38,750 +plasma volume طبعاً هذه ممكن تصير في حالات ال + +87 +00:06:38,750 --> 00:06:43,990 +pregnancy أو في حالات ال volume overload الناس + +88 +00:06:43,990 --> 00:06:47,970 +اللي بتاخد intravenous fluid محلول وريدي و بتكون + +89 +00:06:47,970 --> 00:06:51,210 +كميته كتير كبيرة ممكن يعمل dilution لل blood في + +90 +00:06:51,210 --> 00:06:54,330 +حالات ال congestive heart failure يعني عضلة القلب + +91 +00:06:54,330 --> 00:06:59,280 +مش قادرة تستوعب الدم اللي جايها عشان تعملهبنقله + +92 +00:06:59,280 --> 00:07:03,960 +للرقى ويصير له أكسجر فبصير تجمع لاستوائل فيه خاصة + +93 +00:07:03,960 --> 00:07:07,740 +الجزء اليمين من الجسم وبالتالي بيصير dilution + +94 +00:07:07,740 --> 00:07:13,920 +للبلد طيب هذه عادة بلاقي ال hemoglobin و ال + +95 +00:07:13,920 --> 00:07:18,080 +hematocrit فيها low ليش؟ لأنه صار home dilution مش + +96 +00:07:18,080 --> 00:07:21,180 +لأنه صار نقص في تصنيع ال RBC أو خلل في تصنيع ال + +97 +00:07:21,180 --> 00:07:25,740 +hemoglobin أو ال RBC لأ هنا دراسة طبيعية تظهر عندي + +98 +00:07:25,740 --> 00:07:30,920 +الفرق ما بين ال normal anemiaand الـ Normal عفواً + +99 +00:07:30,920 --> 00:07:35,560 +والـ True Anemia والـ Pseudo Anemia لو تخيلنا عينة + +100 +00:07:35,560 --> 00:07:40,400 +الـ blood بهذا الشكل Hemoglobin فيها 15 الـ + +101 +00:07:40,400 --> 00:07:44,980 +hematocrit 45% عند الـ Normal احنا عارفين 45% + +102 +00:07:44,980 --> 00:07:47,220 +hematocrit طبعا زي ما احنا عارفين ان الـ + +103 +00:07:47,220 --> 00:07:53,960 +hematocrit بيمثل نسبة ال RBC في العينة يعني 45% من + +104 +00:07:53,960 --> 00:07:59,520 +ال sample كلها هتكون hematocrit هتكون RBCتمام؟ هدو + +105 +00:07:59,520 --> 00:08:04,060 +الوضع الطبيعي هلأ في الـ True Anemia هتلاقي أنه + +106 +00:08:04,060 --> 00:08:09,320 +الـ hematocrit قل يعني الـ RBCs نفسها قلت في حين + +107 +00:08:09,320 --> 00:08:13,200 +أنه الـ plasma volume طبيعي يعني لو أجيني أقارنها + +108 +00:08:13,200 --> 00:08:15,820 +الـ plasma volume هذا بال normal plasma volume + +109 +00:08:15,820 --> 00:08:20,300 +هنلاقيهم زي بعض بس مين اللي نقص؟ نقصة الـ RBCs + +110 +00:08:20,300 --> 00:08:25,380 +mass فعليا هنا هتلاقي الـ hematocrit مثلا 30% + +111 +00:08:25,380 --> 00:08:30,660 +والهمoglobin 10هذه حالة أنيميا حقيقية ليش؟ لأن + +112 +00:08:30,660 --> 00:08:35,000 +البلازما حجمها ما اتأثر مقارنة بالنورمال بينما + +113 +00:08:35,000 --> 00:08:39,780 +كمية ال RBCs هي اللي نقصت لو أجينا نشوف + +114 +00:08:39,780 --> 00:08:43,480 +السودوانيميا هنلاقي كمية ال RBCs زيها زي النورمال + +115 +00:08:43,480 --> 00:08:48,280 +لكن كمية البلازما زادت فصار dilution لكل ال + +116 +00:08:48,280 --> 00:08:52,820 +parameters هنلاقي ال hematocrit صار 30% زي وزي ال + +117 +00:08:52,820 --> 00:08:58,340 +true anemia لكن هو فعليا كمية ال RBCsحقيقية زي ما + +118 +00:08:58,340 --> 00:09:01,600 +هي Normal والتصنيعها Normal بس المشكلة أنه صار + +119 +00:09:01,600 --> 00:09:06,820 +Hemodilution بسبب زيادة حجم البلازما وهنا شايفين + +120 +00:09:06,820 --> 00:09:11,260 +طبعا التمثيل للـ 3 حالات للـ Normal و للـ True + +121 +00:09:11,260 --> 00:09:16,220 +Anemia و للـ Pseudo Anemia بشكل يعني واضح احنا + +122 +00:09:16,220 --> 00:09:23,780 +اللي بتهمنا اللي هي الـ True Anemia طيب، + +123 +00:09:23,780 --> 00:09:28,750 +في عندنا ملاحظة مهمة جدايعني يا بنات ممكن تنتين + +124 +00:09:28,750 --> 00:09:35,810 +فيكم يعملوا CBC التنتين يطلعولي يطلع دمهم مثلا 11 + +125 +00:09:35,810 --> 00:09:39,590 +gram per deciliter الهيموجلوبين 11 gram per + +126 +00:09:39,590 --> 00:09:45,730 +deciliter أقول لسين أنت هيموجلوبينك كويس وأقول + +127 +00:09:45,730 --> 00:09:51,050 +لصاد أنت هيموجلوبينك مش كويس ليش؟ خلّيني أفكر + +128 +00:09:51,050 --> 00:09:54,900 +فيها، مع أن التنتين في نفس العمرو نفس الظروف + +129 +00:09:54,900 --> 00:09:58,880 +تقريبا و في نفس البيئة عايشين و ليش انا اعتبرت هذي + +130 +00:09:58,880 --> 00:10:03,140 +Normal و هذي Abnormal فنسين قلتلها ان انت كويسة + +131 +00:10:03,140 --> 00:10:06,920 +لأن انا طول عمري او اكتر من مرة اتجيب لـ CBC يكون + +132 +00:10:06,920 --> 00:10:12,260 +هذا هو ال range الطبيعي لها يعني 11، 11.5، 10.5 هي + +133 +00:10:12,260 --> 00:10:15,800 +دمها هيك ايش ما تعمل مش هيزيد عن هيك لكن التانية + +134 +00:10:15,800 --> 00:10:19,580 +كان دمها 13 انا عارفة ان قبل هيك عملت ال + +135 +00:10:19,580 --> 00:10:24,470 +hemoglobin كان 13 و أجتنياليوم بـ 11 بقولها لأ انت + +136 +00:10:24,470 --> 00:10:28,950 +hemoglobinك نازل اذا ضروري عشان احكم على انسان انه + +137 +00:10:28,950 --> 00:10:32,990 +عنده anemiaيكون فيه فرق بين قراءته الحالية + +138 +00:10:32,990 --> 00:10:38,970 +والقراءات اللي عادة هو يحصل عليها لما بيعمل CBC + +139 +00:10:38,970 --> 00:10:43,170 +تمام؟ «Anemia must also relate to the level of + +140 +00:10:43,170 --> 00:10:46,750 +hemoglobin the individual normally bosses» لازم + +141 +00:10:46,750 --> 00:10:51,770 +أقارنه بالقيمة الطبيعية لهذا الشخص اللي عادة بيكون + +142 +00:10:51,770 --> 00:10:56,330 +الـ hemoglobin بهذا الشكل هنا ضريب لمثالIf an + +143 +00:10:56,330 --> 00:11:00,190 +adult male usually maintains a hemoglobin level 16 + +144 +00:11:00,190 --> 00:11:04,230 +gram per deciliter هو عادة بياخد هذا الرقم 16 gram + +145 +00:11:04,230 --> 00:11:08,650 +per deciliter لكن بعد فترة لاقينا أن الـ + +146 +00:11:08,650 --> 00:11:14,550 +hemoglobin صار 14 لأ هذا معنى الكلام أنه فيه مشكلة + +147 +00:11:14,550 --> 00:11:19,050 +نزلت الأثنين جرام هدول بده متابعة ونشوف إذا كان + +148 +00:11:19,050 --> 00:11:22,050 +صار خلل معين نحاول انعالجه، تمام؟ + +149 +00:11:27,500 --> 00:11:30,840 +عنا مجموعة من الحالات المرضية أنا هيك بحكي roughly + +150 +00:11:30,840 --> 00:11:36,120 +بشكل عام اللي ممكن تكون مسببات لنقص الـ hemoglobin + +151 +00:11:36,120 --> 00:11:40,860 +nutritional deficiencies يعني نقص في المواد + +152 +00:11:40,860 --> 00:11:46,980 +الغذائية قد يكون نقص في قاش، في الحديد، تقم واحد + +153 +00:11:46,980 --> 00:11:51,360 +أول إش تتذكره في الفوليك أسد، في الفوليت أو فوليك + +154 +00:11:51,360 --> 00:11:54,900 +أسد، في vitamin B12 كلها هذه أسباب تؤدي إلى + +155 +00:11:54,900 --> 00:11:59,520 +الأنمياإذن هذه nutritional deficiencies External + +156 +00:11:59,520 --> 00:12:04,480 +or internal blood loss فقد الدم على فترات قد يكون + +157 +00:12:04,480 --> 00:12:10,460 +فقد الدم acute ويؤدي لهبوط في الدم في الـ + +158 +00:12:10,460 --> 00:12:14,600 +hemoglobin وقد يكون chronic إن الإنسان هذا بفقد + +159 +00:12:14,600 --> 00:12:18,620 +كميات بسيطة من الدم على فترات زمنية طويلة فبالتالي + +160 +00:12:18,620 --> 00:12:24,140 +بينشأ عنها أنميا Increased extraction of RBCsتكسير + +161 +00:12:24,140 --> 00:12:28,580 +الـ RBCs لأي سبب من الأسباب قد يكون سبب مناعي قد + +162 +00:12:28,580 --> 00:12:32,380 +يكون يعني في مسببات كتير ممكن تعمل تكسير للـ blood + +163 +00:12:32,380 --> 00:12:35,800 +راح ناخدها ان شاء الله في الـ hemolytic anemia طيب + +164 +00:12:35,800 --> 00:12:39,780 +ineffective or decreased production of RBCs يعني + +165 +00:12:39,780 --> 00:12:42,740 +في مشكلة في ال production للـ RBCs الـ RBCs ما + +166 +00:12:42,740 --> 00:12:50,490 +بتنتج بشكل طبيعي نتيجة خلل معينفي العناصر أو في + +167 +00:12:50,490 --> 00:12:53,810 +الأشياء اللي لازمة لتصنيعها فبالتالي ما بتتصنع + +168 +00:12:53,810 --> 00:12:58,610 +بالشكل السليم abnormal hemoglobin synthesis طبعا + +169 +00:12:58,610 --> 00:13:02,470 +احنا عارفين ان الـ hemoglobin بتتكون من الـ 2α2β- + +170 +00:13:02,470 --> 00:13:10,030 +و الهم طبعا الـ globin اللي هو 2α2β- ممكن يصير فيه + +171 +00:13:10,030 --> 00:13:14,790 +mutations مختلفة و متعددة الـ mutations هذه عادة + +172 +00:13:14,790 --> 00:13:21,380 +تؤدي إلىحدوث خلل في الهيموجلوبين قد يكون هذا + +173 +00:13:21,380 --> 00:13:25,040 +الهيموجلوبين non-functional أو حتى functional لكن + +174 +00:13:25,040 --> 00:13:30,580 +لا يعمل بالصورة الصحيحة أو المطلوبة فبالتالي يؤدي + +175 +00:13:30,580 --> 00:13:35,120 +لانميا bone marrow suppression by toxins أن يصير + +176 +00:13:35,120 --> 00:13:39,360 +تثبيت للـ bone marrow عن طريق الـ toxins عن طريق + +177 +00:13:39,360 --> 00:13:45,420 +بعض الchemicals عن طريق ال radiation عن طريق أن + +178 +00:13:45,420 --> 00:13:50,930 +يصيريكون فيه Malignancy في الجسم مثلًا الجسم صار + +179 +00:13:50,930 --> 00:13:54,550 +فيه Malignancy أو tumor في أي مكان والـ tumor هذه + +180 +00:13:54,550 --> 00:13:58,790 +صار لها انتشار عملت metastasis الـ metastasis هذه + +181 +00:13:58,790 --> 00:14:02,630 +ممكن توصل للـ bone marrow وتحل محل الخلايا + +182 +00:14:02,630 --> 00:14:07,160 +الطبيعيةأو قد من خلايا الـ bone marrow نفسها بعض + +183 +00:14:07,160 --> 00:14:10,240 +الخلايا تتحول لماليجنان cells زي حالات اللوكيميا + +184 +00:14:10,240 --> 00:14:14,800 +وتحل محل الخلايا الطبيعية لمسؤولة عن تصنيع الخلايا + +185 +00:14:14,800 --> 00:14:19,350 +الـnormal عن تصنيع الـRBCs الـnormalفبالتالي بتصير + +186 +00:14:19,350 --> 00:14:23,570 +زي .. زي تنافس في المكان الخلايا بتاعة الـ + +187 +00:14:23,570 --> 00:14:28,110 +Malignant cells نشيطة و بتتكثر بسرعة فبتحل محل + +188 +00:14:28,110 --> 00:14:31,030 +الخلايا اللي هي ماهياش Malignant و اللي هي بتقوم + +189 +00:14:31,030 --> 00:14:34,910 +بوظيفة تصنيع خلايا الدم الحمراء أو بتقوم بتصنيع + +190 +00:14:34,910 --> 00:14:37,370 +الـ Platelets أو أي حاجة تانية فبالتالي بتنافس + +191 +00:14:37,370 --> 00:14:43,170 +Malignant cells لأنها سريعة الانتشار هتنافس + +192 +00:14:43,170 --> 00:14:47,440 +الخلايا الـ Normalوتحل محلها و تخليها يصير في قصور + +193 +00:14:47,440 --> 00:14:50,740 +في وظيفتها لأنها ما بتتصنع بالشكل الصحيح في بعض + +194 +00:14:50,740 --> 00:14:54,680 +الأحيان ممكن ال infection تؤدي إلى أنيميا صحيح في + +195 +00:14:54,680 --> 00:14:58,360 +بعض الحالات اللي ممكن يكون فيها بكتيريا اللي بتسبب + +196 +00:14:58,360 --> 00:15:05,320 +hemolysis لل RBCs طيب تمام نيجي الآن لتعريف + +197 +00:15:05,320 --> 00:15:10,440 +الانيميا functionally يعني كوظيفة كناحية وظيفية في + +198 +00:15:10,440 --> 00:15:15,490 +الجسم إيش بنعرف الانيمياAnemia is defined as + +199 +00:15:15,490 --> 00:15:21,110 +tissue hypoxia يعني نقص الأكسجين الواصل للأنسجة + +200 +00:15:21,110 --> 00:15:27,190 +نقص الأكسجين هذا بيكون بسبب أنه مافي Hemoglobin + +201 +00:15:27,190 --> 00:15:32,090 +كافي يوصل الأكسجين هذا للأنسجة أو سبب تاني عندنا + +202 +00:15:32,090 --> 00:15:37,110 +بمحكيه inability of the body to supply tissue with + +203 +00:15:37,110 --> 00:15:41,470 +adequate oxygen for proper metabolic function يعني + +204 +00:15:41,470 --> 00:15:47,270 +أنهإن الـ Blood مش قادر يوصل كمية الـ Oxygen + +205 +00:15:47,270 --> 00:15:50,970 +الكافية لها الأنسجة عشان تشتغل وتقوم بوظائفها + +206 +00:15:50,970 --> 00:15:55,770 +الحيوية المختلفة قد يكون هذا لأن الـ Hemoglobin + +207 +00:15:55,770 --> 00:16:01,550 +نفسه يعني تصنيعه قليل أو فيه خلل فيه نفسه وقد يكون + +208 +00:16:01,550 --> 00:16:06,220 +الـ Hemoglobin Normalوكميته طبيعية أو حتى أكتر من + +209 +00:16:06,220 --> 00:16:10,360 +الطبيعي لكن الـ Hemoglobin هذا بتميز بـ High + +210 +00:16:10,360 --> 00:16:13,260 +Oxygen Affinity زي ما بتعرفوا Hemoglobin F + +211 +00:16:13,260 --> 00:16:16,800 +Hemoglobin F إله Affinity عالية للأكسجين فلمّا + +212 +00:16:16,800 --> 00:16:19,840 +بيوصل للأنسجة بيضلوا ماسك بالأكسجين ما بيعطيها + +213 +00:16:19,840 --> 00:16:24,430 +للأنسجة عشان تستفيد منهفبالتالي وجوده وعدى مواحد + +214 +00:16:24,430 --> 00:16:28,390 +لما يكون Hemoglobin F موجود وبنسبة عالية برضه + +215 +00:16:28,390 --> 00:16:32,730 +هيكون هذا الشخص عنده Hypoxia في الانسجار ومش هيقدر + +216 +00:16:32,730 --> 00:16:40,310 +الوظائف الحيوانية مش هتنجز بالشكل المطلوب طيب بشكل + +217 +00:16:40,310 --> 00:16:43,770 +عام بنقول أن الانيميا is not a disease هي ليست مرض + +218 +00:16:43,770 --> 00:16:48,010 +وانما عرضbut rather the expression of an + +219 +00:16:48,010 --> 00:16:51,430 +underlying disorder or disease يعني هي ليست مرض + +220 +00:16:51,430 --> 00:16:58,150 +بحد ذاته وإنما هي يعني نتيجة عرض معين نتيجة خلل + +221 +00:16:58,150 --> 00:17:02,690 +معين أو مرض معين الـAnemia هنا بقولك أنت ممكن يظهر + +222 +00:17:02,690 --> 00:17:07,310 +عند الشخص هذا Anemia طبعا إحنا عارفين إنه في توازن + +223 +00:17:07,310 --> 00:17:12,690 +ما بين تصنيع وتكسير هذا طبيعي إحنا عارفينه يعني في + +224 +00:17:13,520 --> 00:17:16,840 +يوميا بدون حالات مرضية بيصير تكسير عدد معين من الـ + +225 +00:17:16,840 --> 00:17:21,340 +RBCs تقريبا 1% وبتصنع مقابل من ال blood ومقابلهم + +226 +00:17:21,340 --> 00:17:24,700 +بتصنع نفس الكمية خلايا جديدة وبتنزل على ال + +227 +00:17:24,700 --> 00:17:28,520 +peripheral blood فبالتالي مافي خلل لكن يوم ما يصير + +228 +00:17:28,520 --> 00:17:32,520 +خلل في هذا التوازن يزيد التكسير عن التصنيع إما + +229 +00:17:32,520 --> 00:17:36,840 +بسبب زيادة التكسير أو بسبب ال bone marrow + +230 +00:17:37,200 --> 00:17:42,440 +submission أو ضعف في إنتاج الـ Boomer للخلايا حتى + +231 +00:17:42,440 --> 00:17:46,760 +تنشأ عندنا الانيميا يعني الانيميا طالما اختلف + +232 +00:17:46,760 --> 00:17:50,500 +توازن ما بين الفاقد و ما بين المنتج هيصير انيميا + +233 +00:17:50,500 --> 00:17:55,240 +يعني المنتج قليل و الفاقد كتير حيصير عندنا حالة + +234 +00:17:55,240 --> 00:18:01,260 +انيميا في حالة ما يصير في انيميا أو hypoxia كيف + +235 +00:18:01,260 --> 00:18:06,660 +الجسم بتصرف hematologic response to anemiaالان لو + +236 +00:18:06,660 --> 00:18:10,560 +صار تيشو هيبوكسيا الانسجا في الجسم هيصير نقص + +237 +00:18:10,560 --> 00:18:17,140 +أكسوجين فيها ومن ضمن الانسجا النسيج تاع الكدن كدني + +238 +00:18:17,140 --> 00:18:21,500 +هتتنبه أنه صار فيه هيبوكسيا يعني ما بوصلها أكسوجين + +239 +00:18:21,500 --> 00:18:27,400 +كفاية فهتروح مباشرة الكدن تطلق هرمون الارثروبيوتين + +240 +00:18:28,110 --> 00:18:32,110 +الـ Erythrobiotin هذا بيروح للبون مارو و بعمل + +241 +00:18:32,110 --> 00:18:39,210 +acceleration لعملية الـ Erythropoiesis يعني بنشط + +242 +00:18:39,210 --> 00:18:43,870 +أو بحفظ عملية الـ Erythropoiesis بقولك يعني ممكن + +243 +00:18:43,870 --> 00:18:49,290 +البون مارو يضاعف نشاطه 7 إلى 8 مرات الوضع الطبيعي + +244 +00:18:49,880 --> 00:18:53,620 +في هذه الحالة الـ bone marrow هيصير hypercellular + +245 +00:18:53,620 --> 00:18:57,240 +طبعاً، مين اللي هيزيد؟ يعني إيش اللي هيصير فعلياً + +246 +00:18:57,240 --> 00:18:59,640 +في الـ bone marrow؟ لأنه لو طلع الـ erythropoietin + +247 +00:18:59,640 --> 00:19:02,960 +بكمية كبيرة أول حاجة، هيصير الـ bone marrow + +248 +00:19:02,960 --> 00:19:07,820 +hypercellular نتيجة زيادة الـ erythroid بـ + +249 +00:19:07,820 --> 00:19:11,560 +precursors، تمام؟ عشان هيك بنسميها erythroid + +250 +00:19:11,560 --> 00:19:15,600 +hyperplasia طبعاً، إحنا عندنا الـ myeloid + +251 +00:19:15,600 --> 00:19:19,990 +erythroid ratio هذه، اللي لها ثابتةهنلاقي إن الـ + +252 +00:19:19,990 --> 00:19:24,630 +Erythroid cells هتزيد تمام فبالتالي النسبة هذه + +253 +00:19:24,630 --> 00:19:30,110 +هتصير قليلة، انخفاض، ليش؟ لأن الـ Erythroid هتزيد + +254 +00:19:30,110 --> 00:19:32,830 +و هذه هتظل ثابتة فبالتالي هيصير انخفاض في الـ + +255 +00:19:32,830 --> 00:19:35,950 +Myeloid Erythroid Ratio إذن أول حاجة الـ bone + +256 +00:19:35,950 --> 00:19:39,110 +marrow hypercellular شغل تاني الـ Myeloid + +257 +00:19:39,110 --> 00:19:43,650 +Erythroid Ratio هيصير لها fall شغل كتير مهمة وهدي + +258 +00:19:43,650 --> 00:19:46,330 +يعني أنا بشوفها في الـ peripheral blood وجود + +259 +00:19:46,330 --> 00:19:53,020 +شغلتان أول حاجةموجود Nucleated RBCs طبعا خلّينا + +260 +00:19:53,020 --> 00:19:58,480 +نتذكر مع بعض هيك شوية احنا عارفين ان الـ RBCs بتمر + +261 +00:19:58,480 --> 00:20:02,880 +بمراحل في التصنيع أول اشي Pro-Normoblast + +262 +00:20:02,880 --> 00:20:07,760 +Normoblast تلت مراحل اللي هي Basophilic + +263 +00:20:07,760 --> 00:20:12,220 +Polychromatic Orthochromic Normoblast لغاية هنا + +264 +00:20:12,220 --> 00:20:16,580 +كله هدف البونمارو تمام؟ لكن + +265 +00:20:18,560 --> 00:20:24,140 +لو صار فيه حاجة لخلايا أو فيه ضغط ممكن يصير الـ + +266 +00:20:24,140 --> 00:20:28,340 +Bone marrow يطلع هذه اللي هي الـ Normoblast اللي + +267 +00:20:28,340 --> 00:20:31,240 +هي الـ Nucleated RBCs على الـ Peripheral Blood + +268 +00:20:31,240 --> 00:20:36,160 +عشان فيه حاجة مهسة إلها فبالتالي هنلاقي فيه ارتفاع + +269 +00:20:36,160 --> 00:20:40,330 +في الـ Nucleated RBCs هذه الشيءفي الـ «Blood» فيلم + +270 +00:20:40,330 --> 00:20:44,530 +العادي إذن ممكن نشوف «Nucleated RBC» أو نشوف + +271 +00:20:44,530 --> 00:20:48,150 +«Polychromatic Cell» أو «Polychromagia» فاكرين إيش + +272 +00:20:48,150 --> 00:20:52,570 +يعني Polychromagia؟ فاكرين لما حكينا + +273 +00:20:52,570 --> 00:20:57,190 +«Reticulocyte» + +274 +00:20:57,190 --> 00:21:01,270 +يعني خليني نكمل السلسلة اللي قلناها عشان نشبك + +275 +00:21:01,270 --> 00:21:04,010 +الكلام ببعضه فلقيت إحنا قلنا فينا تلت مراحل + +276 +00:21:04,010 --> 00:21:07,850 +«Normal» و «Blast»بعد التلات مراحل هدول بتيجي عند + +277 +00:21:07,850 --> 00:21:13,230 +الـ reticulocyte صح؟ اللي هي الخلية الشبكية اللي + +278 +00:21:13,230 --> 00:21:20,370 +فيها بقايا من الـ RNA reticulocyte هذه عادة عمرها + +279 +00:21:20,370 --> 00:21:25,370 +كله على بعض 72 يوم عفوا + +280 +00:21:25,370 --> 00:21:30,880 +عفوا sorry 72 ساعةهدول 72 ساعة اللي هم تلت أيام + +281 +00:21:30,880 --> 00:21:33,880 +بتقضي منهم يومين في الـ bone marrow واليوم الأخير + +282 +00:21:33,880 --> 00:21:36,900 +بتقضي في ال peripheral blood فأنا في الوضع الطبيعي + +283 +00:21:36,900 --> 00:21:39,280 +بشوف عدد قليل من ال reticulocyte في ال peripheral + +284 +00:21:39,280 --> 00:21:42,920 +blood وقدرناه إذا كنتوا فاكدين 1% تقريبا من نص إلى + +285 +00:21:42,920 --> 00:21:48,760 +1.5% في ال normal صحيح؟ لكن في ال stress أو تحت + +286 +00:21:48,760 --> 00:21:53,780 +ضغط معين هتبلش ال reticulocyteمجرد ما تتكون، تطلع، + +287 +00:21:53,780 --> 00:21:57,500 +يعني مش هتقض يومين في الـ «بون مارو» و بعدين اتكمل + +288 +00:21:57,500 --> 00:22:01,140 +في الـ «بريفرال بلد»، لأ، هتطلع مباشرة من الـ «بون + +289 +00:22:01,140 --> 00:22:04,580 +مارو» و اتطول في الـ «بريفرال بلد»، فهتبلش تتراكم + +290 +00:22:04,580 --> 00:22:09,380 +تاعت اليوم و تاعت اول امبارح، حتى كمية الـ + +291 +00:22:09,380 --> 00:22:13,500 +reticulocyte بلش تتزيد كتير في الـ «بريفرال بلد» + +292 +00:22:13,500 --> 00:22:16,480 +الـ reticulocyte طبعا أنا في الـ blood film العادي + +293 +00:22:17,420 --> 00:22:21,020 +يعني ما بعدها من الـ Blood Film العادى إذا كنتوا + +294 +00:22:21,020 --> 00:22:23,840 +فاكرين كان لها صبغة خاصة اسمها Supravitalistin + +295 +00:22:23,840 --> 00:22:27,540 +تصبغ الخلية و هي حية لكن في الـ Blood Film العادى + +296 +00:22:27,540 --> 00:22:31,560 +طبعا احنا عارفين الـ RBCs دولها Pink هي مع الـ + +297 +00:22:31,560 --> 00:22:36,910 +Pink بتعطي شوية زرقة فبسميها Polychromagiaاللون + +298 +00:22:36,910 --> 00:22:40,130 +الأزرق معين هذا يعني أنا كل الكلام اللي قلته عشان + +299 +00:22:40,130 --> 00:22:43,570 +أذكركم بإيش هي الـ Polychromagia Polychromagia هي + +300 +00:22:43,570 --> 00:22:48,070 +الـ reticular قلاية RBCs هي عبارة أصلا عن + +301 +00:22:48,070 --> 00:22:51,690 +reticulocyte لسه immature RBCs موجودة في الـ + +302 +00:22:51,690 --> 00:22:55,430 +peripheral blood و بتظهر باللون ال pink المطعم أو + +303 +00:22:55,430 --> 00:23:00,690 +الملون باللون الأزرق الخفيف و تتراكم إذن هذه + +304 +00:23:00,690 --> 00:23:05,880 +وجودها بكمية كبيرة مؤشر من مؤشراتالـ Accelerated + +305 +00:23:05,880 --> 00:23:10,680 +Erythropoiesis تمام؟ أو Erythroid Hyperepalgia + +306 +00:23:10,680 --> 00:23:19,480 +تفضيخ + +307 +00:23:19,480 --> 00:23:24,320 +للكلام اللي حكيناه توي أو شرحناه بذكركم هاي الـ + +308 +00:23:24,320 --> 00:23:27,800 +Maturation Series بتاعة ال RVCs هاي هنا الـ + +309 +00:23:27,800 --> 00:23:33,560 +Normoblast التلاتةتلت مراحل لانورموبلاست هيهم بعد + +310 +00:23:33,560 --> 00:23:36,340 +هيك بتجين ال reticulocyte لغاية هنا هذا كله في ال + +311 +00:23:36,340 --> 00:23:39,220 +bone marrow ال reticulocyte بعد يومين من تصنيعها + +312 +00:23:39,220 --> 00:23:42,420 +بتطلع على ال peripheral blood و بتبين باللون اللي + +313 +00:23:42,420 --> 00:23:47,660 +هو الأحمر او الزهري المائل للزرافة هنا هذا الرسمة + +314 +00:23:47,660 --> 00:23:50,720 +بيذكرني او هذه الشريحة بيذكرني فيها في اماكن تصنيع + +315 +00:23:50,720 --> 00:23:55,130 +ال RBCsبقولك لو صار ضغط زيادة على البون مروء + +316 +00:23:55,130 --> 00:23:59,050 +والبون مروء مش قادر يطلع الدم يعني كمية ال blood + +317 +00:23:59,050 --> 00:24:03,510 +اللي لازمة ممكن يرجع يصنع ال blood extra-medullary + +318 +00:24:03,510 --> 00:24:05,750 +احنا عارفين أنه في الـ Adult ميدلاري في الـ Flat + +319 +00:24:05,750 --> 00:24:09,270 +bone في الـ Red marrow في العظام في الأماكن + +320 +00:24:09,270 --> 00:24:12,570 +المحددة في البون مروي اللي هو Red بيصير تصنيع ال + +321 +00:24:12,570 --> 00:24:16,850 +RBC في البون مروي لكن لو صار ضغط و هذا ماقدر يقوم + +322 +00:24:16,850 --> 00:24:20,940 +بالواجب بالشكل الكافيهيرجع التصنيع extra-medullary + +323 +00:24:20,940 --> 00:24:24,400 +يعني هيصير برضه ترجع الـ liver و الـ spleen يتصنع + +324 +00:24:24,400 --> 00:24:27,340 +طبعاً مافيش يوكساك عشان يصنع هو هنا بقولك في + +325 +00:24:27,340 --> 00:24:30,100 +الحياة الجنينية كيف ممكن يكون باليوكساك و في الـ + +326 +00:24:30,100 --> 00:24:32,000 +liver و بالـ spleen بعدين بيصير في الـ bone marrow + +327 +00:24:32,000 --> 00:24:37,600 +لكن ممكن أنه يصير في ال liver و في الـ spine حتى + +328 +00:24:37,600 --> 00:24:40,660 +في الـ adult إذا الجسم بتاعه حاول يصنع من هذا + +329 +00:24:40,660 --> 00:24:44,360 +الجسم قدرة الجسم أنه يعمل adaptation مع الانيميا + +330 +00:24:44,360 --> 00:24:50,010 +يعني بتشوفي واحدة بتقولك أنا دمي سبعةوأنا طول عمري + +331 +00:24:50,010 --> 00:24:53,930 +دم سبعة أنا شوفت واحدة وماشية وعادي وبتشتغل وموظفة + +332 +00:24:53,930 --> 00:24:56,850 +وبتقولك أنا دم سبعة ومنيح لما بيكون سبعة وممكن + +333 +00:24:56,850 --> 00:24:59,690 +يكون ستة وممكن يكون أقل من هاد ولو بتنقليش تم + +334 +00:24:59,690 --> 00:25:03,410 +تقولي لأ أنا خلاص متعودة على هاد هادي صار عندها + +335 +00:25:03,410 --> 00:25:07,150 +adaptation صار عندها تأقلم على هذا الوضع على وضع + +336 +00:25:07,150 --> 00:25:12,250 +الانيميا هادى طبعا هذا بيعتمد على عدة عوامل ال age + +337 +00:25:13,440 --> 00:25:18,100 +والحالة المرضية يعني إيش المرض المصاحب لحالة + +338 +00:25:18,100 --> 00:25:23,200 +الانيميا هذه طبعا ال age كل ما كان العمر أصغر كل + +339 +00:25:23,200 --> 00:25:26,240 +ما كان ال adaptation كل ما كان عند الإنسان قدرة + +340 +00:25:26,240 --> 00:25:29,480 +على ال adaptation أكتر شغلة تانية اللي هي ال + +341 +00:25:29,480 --> 00:25:33,580 +cardio pulmonary function طبعا البنات لو صار + +342 +00:25:33,580 --> 00:25:39,500 +انيميا عند الشخص هيصير overload على ال heart ليش؟ + +343 +00:25:39,500 --> 00:25:43,200 +لأن القلب وظيفته يضخ الدم ويوصل ال oxygenهلقيت لما + +344 +00:25:43,200 --> 00:25:47,900 +الانسجار يكون فيها Hypoxia حيصير القلب يضاعف + +345 +00:25:47,900 --> 00:25:53,380 +مجهوده علشان يوصل Oxygen أكتر للانسجار فإذا كان + +346 +00:25:53,380 --> 00:25:56,880 +القلب والرئتين بتحملوا الكلام هذا السؤال هل هما + +347 +00:25:56,880 --> 00:26:00,600 +بتحملوا ولا في مشكلة أصلا ومع الأنيميا زادت أو + +348 +00:26:00,600 --> 00:26:05,600 +بينت أو انكشفت فبالتالي وظيفة القلب والرئتين مهمة + +349 +00:26:05,600 --> 00:26:12,500 +في موضوع ال adaptation مع الأنيميا شغل تانيةRate + +350 +00:26:12,500 --> 00:26:17,000 +at which anemia develops يعني الأنيميا هادى هل + +351 +00:26:17,000 --> 00:26:20,980 +حصلت فجأة يعني أحسن المثال الشخص هذا أصيب بحادث + +352 +00:26:20,980 --> 00:26:25,840 +ونزف كمية كبيرة من الدم هنا زي بيصير لسه الـ + +353 +00:26:25,840 --> 00:26:29,880 +Bulmar وبدو وقت لما يستوعب الموضوع لكن واحد عنده + +354 +00:26:29,880 --> 00:26:33,380 +نزيف داخلي مثلا لسبب من الأسباب ممكن نزيف بسيط، + +355 +00:26:33,380 --> 00:26:37,140 +نزيف لسه، نزيف مش عارفش وهذا يعني من وقت طويل + +356 +00:26:37,140 --> 00:26:41,960 +وشوية شوية بيصير بشكل chronicطبعا هنا الـ bone + +357 +00:26:41,960 --> 00:26:46,500 +marrow هيبدأ يتعود ويأقلم حاله أنه يعوض هذا الخلل + +358 +00:26:46,500 --> 00:26:53,080 +بطريقة منظمة على خلاف اللي بفقد كميات كبيرة من + +359 +00:26:53,080 --> 00:26:56,520 +الذنب مرة واحدة أنا قلت يعني فقد الذنب كمثال + +360 +00:26:56,940 --> 00:26:59,300 +والانيميا نفس الأشياء يعني أي نوع من أنواع + +361 +00:26:59,300 --> 00:27:02,740 +الانيميا إذا كانت الانيميا بتتطور بطيئا بتعود + +362 +00:27:02,740 --> 00:27:07,500 +عليها الجسم لكن إذا كانت يعني تتكونت فجأة لسبب + +363 +00:27:07,500 --> 00:27:13,060 +مفاجئ لأ الجسم بيكون التعود عليها مش سهل و مش بسيط + +364 +00:27:13,060 --> 00:27:17,080 +ال + +365 +00:27:17,080 --> 00:27:22,460 +symptoms العامة للانيميا أو للـ Hypoxia طبعا هي + +366 +00:27:22,460 --> 00:27:27,410 +أعراض نقص الأكسجين اللي بيوصل للأنسجةبشكل عام، + +367 +00:27:27,410 --> 00:27:32,370 +fatigue، faintness، يعني إرهاق عام لأن العضلات ما + +368 +00:27:32,370 --> 00:27:37,070 +بوصل لها أكسوجين كافي عشان تشتغل كويس، شحوب، ضعف + +369 +00:27:37,070 --> 00:27:42,810 +عام، دوخة، صداع، poor exercise tolerance، لو ماشي + +370 +00:27:42,810 --> 00:27:45,650 +شوية طلع درج بسيريال، هاتوا بتعبوا، بتعرقوا، + +371 +00:27:45,650 --> 00:27:50,610 +مابقدرش يتحملleg cramps تقلصات في الرجلين في عضلات + +372 +00:27:50,610 --> 00:27:55,090 +الرجلين ليش؟ لأن الرجلين مش قادرين يعني يعني + +373 +00:27:55,090 --> 00:27:58,210 +العضلات مش واصلها أكسوجين كفاية عشان تشتغل + +374 +00:27:58,210 --> 00:28:05,670 +فبالتالي ممكن يصير فيها تشنجات أو تقلصات في + +375 +00:28:05,670 --> 00:28:11,170 +عندنا في بعض الأحيان بعض ال signs بتكون general و + +376 +00:28:11,170 --> 00:28:15,170 +بعضها بتكون specific يعني عندنا general signs زي + +377 +00:28:15,170 --> 00:28:19,270 +شحوبالشحوب هذا عادةً أي واحد Hemoglobinه أقل من 9 + +378 +00:28:19,270 --> 00:28:23,930 +هتلاقي Baylor of mucous membrane هتلاقي كل فيه + +379 +00:28:23,930 --> 00:28:27,950 +شحوب عنده يعني لو شفنا جفن العين من جوا هنلاقي فيه + +380 +00:28:27,950 --> 00:28:32,530 +لان شاحب كتير فاتح كتير مثلا والوجه بشكل عام + +381 +00:28:32,530 --> 00:28:36,510 +بتحسيه شاحب الصداعي الدوخة هذه علامات عامة للأنميا + +382 +00:28:36,510 --> 00:28:42,190 +لكن في عندي أشياء خاصة ممكن تدلل على نوع الأنميا + +383 +00:28:42,190 --> 00:28:46,950 +زي مثلاالصفار اللي زي الـ Giandes اليرقان Giandes + +384 +00:28:46,950 --> 00:28:50,450 +كان بسبب ارتفاع البليروبين طب ماهو ارتفاع + +385 +00:28:50,450 --> 00:28:53,710 +البليروبين؟ بليروبين ارتفاع يعني فيه Hemoglobin + +386 +00:28:53,710 --> 00:28:58,370 +اتكسر يعني فيه تكسير يعني فيه Hemolytic Anemia إذن + +387 +00:28:58,370 --> 00:29:01,430 +وجود Giandes بقول إنه فيه Hemolytic Anemia بس إيش + +388 +00:29:01,430 --> 00:29:03,750 +نوع الـ Hemolytic Anemia ما بيقولّي بيعطيني + +389 +00:29:03,750 --> 00:29:08,230 +indication على ال category تاعت الأنميا شغل تانية + +390 +00:29:08,230 --> 00:29:12,720 +Leg Ulcersأحياناً بيكون فيه تقرحات في الرجلين أو + +391 +00:29:12,720 --> 00:29:16,920 +في أماكن معينة من الجسم هذه عادةً بتكون من الـ + +392 +00:29:16,920 --> 00:29:19,620 +Sickle Cell Anemia لأن الـ Sickle Cells ممكن تعمل + +393 +00:29:19,620 --> 00:29:23,720 +تسديد للأوعية الدموية الدقيقة و تبدأ الأوعية هذه + +394 +00:29:23,720 --> 00:29:28,100 +لما تسدد ما يوصلها أكسجين بشكل كافي فتبدأ تتطور + +395 +00:29:28,100 --> 00:29:34,620 +الشغل لمراحل Microsis أو مواد في الأنسجة و Ulcers + +396 +00:29:34,620 --> 00:29:35,340 +and so on + +397 +00:29:38,860 --> 00:29:42,820 +طيب نيجي للـ diagnosis of anemia انا لما بدي اشخص + +398 +00:29:42,820 --> 00:29:46,980 +الانيميا قبل ما اعمل اي diagnosis للانيميا لازم + +399 +00:29:46,980 --> 00:29:56,560 +انتبه لاج six geographical location العمر الجنس + +400 +00:29:56,560 --> 00:30:02,920 +المكان الجغرافي وارتفاعه عن سطح البحر دلوقت بدنا + +401 +00:30:02,920 --> 00:30:06,850 +نشوف كيف بدنا نعمل diagnosis للانيمياclinical + +402 +00:30:06,850 --> 00:30:11,410 +diagnosis of anemia الآن تشخيص الانيميا تلت مراحل + +403 +00:30:11,410 --> 00:30:15,310 +رئيسية ناخد فيها ال patient history و physical + +404 +00:30:15,310 --> 00:30:18,270 +examination و ال lab investigations هناخدهم هيك + +405 +00:30:18,270 --> 00:30:22,170 +على السريع واحدة واحدة بداية ال patient history + +406 +00:30:22,170 --> 00:30:27,350 +بدنا نشوف تعادات الغذائية للمريض هل هو من النوع + +407 +00:30:27,350 --> 00:30:31,430 +اللي بيهتم بالغذاء المتكامل الصحي اللي فيه ال + +408 +00:30:31,430 --> 00:30:35,970 +vitamins اللي فيه العناصر الغذائية الرئيسيةولّا + +409 +00:30:35,970 --> 00:30:39,190 +معتمد على الواجبات السريعة الـ junk foods والأشياء + +410 +00:30:39,190 --> 00:30:42,850 +اللي زي هيك طبعا هذه بـ يعني مافيش فيها عناصر + +411 +00:30:42,850 --> 00:30:46,890 +غذائية ممكن تأثر على تعمل أنميا Medications هل + +412 +00:30:46,890 --> 00:30:50,450 +بياخد أدوية معينة؟ ممكن بعض الأدوية تأتي بمردود + +413 +00:30:50,450 --> 00:30:53,710 +سلبي على تصنيع الـ hemoglobin وعلى قدرة الـ bone + +414 +00:30:53,710 --> 00:30:57,750 +marrow وعلى إنتاج الخلايا هل تعرض إلى بعض ال + +415 +00:30:57,750 --> 00:31:01,250 +chemicals مثلا أخد chemicals أخد chemotherapy أو + +416 +00:31:01,250 --> 00:31:06,730 +تعرض لبعض ال toxins؟description and duration of + +417 +00:31:06,730 --> 00:31:10,330 +symptoms يعني الآن أنت من وقتيش عندك الأعراض هذه + +418 +00:31:10,330 --> 00:31:15,090 +من زمان مثلا طول عمري بعاني من الأعراض هذه من شهر + +419 +00:31:15,090 --> 00:31:18,430 +من أسبوع كل هذا إله دلائل مثلا أخدت علاج وبعد + +420 +00:31:18,430 --> 00:31:21,110 +العلاج هذا بدت معايا الأعراض كلها هذه الـhistory + +421 +00:31:21,110 --> 00:31:26,050 +مهمة عشان الدكتور يكوّن في دماغه صورة متكاملة عن + +422 +00:31:26,050 --> 00:31:29,730 +حالة ال patient هذا ويعرف إيش الخطوة التالية يعني + +423 +00:31:29,730 --> 00:31:34,670 +إيش الخطوة التي تتلي خطوة الـhistoryاشو يطلبله + +424 +00:31:34,670 --> 00:31:40,670 +تحليل and so on tiredness يعني هل هو short history + +425 +00:31:40,670 --> 00:31:43,970 +برضه اش بياخد فيه muscle fatigue or weakness هل + +426 +00:31:43,970 --> 00:31:48,570 +بتعاني من muscle fatigue او weakness headache او + +427 +00:31:48,570 --> 00:31:55,620 +اللي هي الدزنس الدوار او الزغللة dyspneaاللي هي + +428 +00:31:55,620 --> 00:31:58,940 +تسميها صعوبة في التنفس يعني هل مثلا عندك ضيقة نفس + +429 +00:31:58,940 --> 00:32:02,620 +بتحس أنه لما بتيجي تطلع درج لما هدا بتضايق بتزيد + +430 +00:32:02,620 --> 00:32:06,240 +ضربات قلبك ومثلا بيصير عندك صعوبة في التنفس، هل + +431 +00:32:06,240 --> 00:32:09,660 +عندك مشاكل في الـ gastrointestinal tract، overt + +432 +00:32:09,660 --> 00:32:13,100 +signs of blood loss such as هيماتوريا، حاجات واضحة + +433 +00:32:13,100 --> 00:32:16,240 +زي الهيماتوريا أو black spool، كل هذه دلائل على + +434 +00:32:16,240 --> 00:32:18,580 +إنه في فاقد للدم، في blood loss + +435 +00:32:21,670 --> 00:32:26,310 +طيب نيجي ل الـ Physical Examination برضه هذا يعني + +436 +00:32:26,310 --> 00:32:31,190 +الدكتور اللي .. يعني شغل .. شغل الطبيب مش شغلنا + +437 +00:32:31,190 --> 00:32:35,370 +احنا أول حاجة بشكل عام ممكن يلاقي عنده Hepato + +438 +00:32:35,370 --> 00:32:38,990 +-splenomegalate ليش؟ لأن زي ما قلنا ال liver و ال + +439 +00:32:38,990 --> 00:32:42,350 +spleen بيحسيروا بدهم يتنشطوا من دوره جديد extra + +440 +00:32:42,350 --> 00:32:46,050 +medullary hematopoiesis ويصنعوا دم بيدهم ي sendوا + +441 +00:32:46,050 --> 00:32:51,010 +ال bone marrow عشان يغطوا العجزHeart abnormalities + +442 +00:32:51,010 --> 00:32:53,390 +مشاكل في الـ heart لأن الـ heart هيصير عليه + +443 +00:32:53,390 --> 00:32:56,730 +overload هيصير يشتغل بزيادة عشان يوصل الأكسجين + +444 +00:32:56,730 --> 00:33:01,770 +أكتر للأنسجة skin baler شحوب في الجلد أو في البشرة + +445 +00:33:01,770 --> 00:33:09,350 +بشكل أكبر طيب specific finding يعني هذه أشياء خاصة + +446 +00:33:09,350 --> 00:33:14,710 +ببعض الحالات المرضية فلقيت مثلا في حالة الـ + +447 +00:33:14,710 --> 00:33:20,010 +vitamin B12 deficiencyهتلاقي signs of malnutrition + +448 +00:33:20,010 --> 00:33:24,370 +هنلاقي عند الشخص أعراض سوء التغذية بالإضافة إلى + +449 +00:33:24,370 --> 00:33:29,130 +بعض الأعراض اللي لها علاقة بالأعصاب يعني ممكن + +450 +00:33:29,130 --> 00:33:33,290 +تلاقي مثلا عندها الرجبة في إيديها عندها بعض + +451 +00:33:33,290 --> 00:33:39,410 +التشنجات البسيطة في أصابعها هذه ممكن خدل هذه عادة + +452 +00:33:39,410 --> 00:33:43,340 +بقول الدكتور أحتمال يكون عندها B12 deficiencyهلقد + +453 +00:33:43,340 --> 00:33:47,740 +في الـ iron deficiency مثلا بنلاقي severe pallor + +454 +00:33:47,740 --> 00:33:52,140 +ال tongue بيكون smooth، smooth tongue اللسان and + +455 +00:33:52,140 --> 00:34:00,260 +esophageal webs بتلاقي زي طبقات أو طب بتكون مغطية + +456 +00:34:00,260 --> 00:34:05,430 +ال esophagusin hematologic anemia عفوًا hemolytic + +457 +00:34:05,430 --> 00:34:08,930 +anemia طبعًا عادة في الـ hemolytic anemia ممكن + +458 +00:34:08,930 --> 00:34:12,410 +ألاقي joints واضح صفار واضح نتيجة وجود باليروبين + +459 +00:34:12,410 --> 00:34:17,790 +وتكثير لل RBCs نتيجي ثالثًا في ال diagnosis + +460 +00:34:17,790 --> 00:34:21,990 +للأنيميا اللي هو ال lab diagnosis اللي هو شغلنا + +461 +00:34:21,990 --> 00:34:26,870 +أول حاجة طبعًا بطلبها الدكتور اللي هو ال CBC CBC + +462 +00:34:26,870 --> 00:34:33,210 +ينطلق منه للأشياء التالية إذا بطلب CBCبطلب blood + +463 +00:34:33,210 --> 00:34:38,530 +smear عشان يعمل evaluation للـ boiculocytosis يشوف + +464 +00:34:38,530 --> 00:34:41,430 +إذا فيها أنزوسيتوزيز إذا فيها ممكن يطلب bone + +465 +00:34:41,430 --> 00:34:45,430 +marrow biopsy bone marrow biopsy ممكن نشوف من + +466 +00:34:45,430 --> 00:34:49,270 +خلالها شوف يا بنات ال bone marrow biopsy يعني + +467 +00:34:49,270 --> 00:34:52,630 +خلينا نكون واقعيين مش كتير بتنطلب يعني بتنطلبش + +468 +00:34:52,630 --> 00:34:56,630 +للأنيميا بتنطلب بس في حالات زي مثلا يعني حالات + +469 +00:34:56,630 --> 00:35:01,710 +فعلا هم مش قادرين يشخصوها حالات ال aplastic anemia + +470 +00:35:01,970 --> 00:35:05,610 +مش يعني مريض الانيميا العادي مابناخدش منه bone + +471 +00:35:05,610 --> 00:35:08,670 +marrow biopsy يعني خلينا نكون في واقعيين و في صورة + +472 +00:35:08,670 --> 00:35:12,890 +الوضع يعني لكن انا بقولك ال bone marrow biopsy لو + +473 +00:35:12,890 --> 00:35:16,130 +احنا عملناها ممكن نشوف ال maturation of RBCs and + +474 +00:35:16,130 --> 00:35:19,820 +YPCs seriesنشوف نسبة الـ Myeloid للـ Erythroid + +475 +00:35:19,820 --> 00:35:25,520 +abundance of iron stars كمية الـ iron stars مثلاً + +476 +00:35:25,520 --> 00:35:28,580 +هل هي قليلة، هل هي كتيرة، طبعاً في الـ iron + +477 +00:35:28,580 --> 00:35:30,980 +deficiency بيكون قليلة في الـ Sodroplastic anemia + +478 +00:35:30,980 --> 00:35:35,820 +بتزيد and so on presence or absence of granuloma + +479 +00:35:35,820 --> 00:35:40,520 +or tumor cells، يعني هل في مثلاًأثر على تصنيع الدم + +480 +00:35:40,520 --> 00:35:44,280 +وجود خلايا tumor أو cancer أو malignant cells هذه + +481 +00:35:44,280 --> 00:35:48,660 +الخلايا قدت لنقص تصنيع الخلايا الطبيعية Red to + +482 +00:35:48,660 --> 00:35:51,740 +Yellow Ratio طبعا عارفين الـ Red to Yellow Ratio + +483 +00:35:52,020 --> 00:35:54,620 +اللي هي الـ Red bone marrow الـ Active واليالو + +484 +00:35:54,620 --> 00:35:57,800 +اللي هو الـ Inactive فبتشوفوا ال ratio بينه + +485 +00:35:57,800 --> 00:36:01,640 +Presence of megakaryocyte زي ما بقولكم تاني أنه في + +486 +00:36:01,640 --> 00:36:04,600 +الأنميا ما بنطلب bone marrow إلا في بعض الحالات + +487 +00:36:04,600 --> 00:36:07,720 +الصعبة يعني أنا ماباروح أطلب bone marrow عشان أشوف + +488 +00:36:07,720 --> 00:36:11,260 +ال iron stores وانا عندي الحديد في الدم ممكن أشوفه + +489 +00:36:11,260 --> 00:36:13,660 +ال iron و ال total iron binding كبسط زي ما قدنا + +490 +00:36:13,660 --> 00:36:16,900 +نشوفه بس ممكن في ال aplastic anemia في الحالات + +491 +00:36:16,900 --> 00:36:20,200 +اللي يعنيتبقى فعلا أنا شاك كأنه يعني إيش ما أعطي، + +492 +00:36:20,200 --> 00:36:23,280 +إيش ما أعطي، مافيش استجابة وانا شاك كأنه فيه خلل + +493 +00:36:23,280 --> 00:36:25,980 +في البونمارو ممكن يطلبوا بونمارو biopsy أما في + +494 +00:36:25,980 --> 00:36:30,800 +الوضع العادي لأممكن يعملوا Hemoglobin + +495 +00:36:30,800 --> 00:36:34,300 +Electrophoresis طبعا عشان يشوفوا أي أنواع تانية من + +496 +00:36:34,300 --> 00:36:37,900 +الـ Abnormal Hemoglobin زي Hemoglobin S، D، G، + +497 +00:36:37,900 --> 00:36:42,900 +Hemoglobin C كل هذه الأنواع بتظهر الـ Hemoglobin + +498 +00:36:42,900 --> 00:36:45,060 +وBethes طبعا وأنواع الـ Hemoglobin الـ Abnormal + +499 +00:36:45,060 --> 00:36:50,580 +بتظهر في الـ Hemoglobin Electrophoresis ممكن ينطلب + +500 +00:36:50,580 --> 00:36:53,840 +Antiglobulin Testing ممكن ينطلب Osmotic Fragility + +501 +00:36:53,840 --> 00:36:57,710 +Testing ممكن ينطلب Sickle Cell Testممكن ينطلب + +502 +00:36:57,710 --> 00:37:01,250 +Sucrose Test عشان الـ BNH إذا كنت فاكريني يعني كل + +503 +00:37:01,250 --> 00:37:05,190 +الفحصات اللي احنا درسناها في الـ Hematology اللي + +504 +00:37:05,190 --> 00:37:08,450 +لاتش ممكن ينطلب فحص مثلا Hemoglobin A2 ممكن نعمل + +505 +00:37:08,450 --> 00:37:11,830 +Quantitation لـ Hemoglobin F كل هذه الأشياء ممكن + +506 +00:37:11,830 --> 00:37:15,270 +تنطلب ممكن ينطلب Iron Total Iron Binding Capacity + +507 +00:37:15,270 --> 00:37:18,490 +يعني في مجموعة فحصات Kinestry ممكن تنطلب في بعض + +508 +00:37:18,490 --> 00:37:22,350 +الأحيان Folic Acid Folate Vitamin B12 كله هاد عشان + +509 +00:37:22,350 --> 00:37:25,870 +بالنهاية نعرف إيش النوع الصحيح للأداميا + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/0_i7Eeu5nU0_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/0_i7Eeu5nU0_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..0e834840b368e150362f4cb842f3604fd8644623 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/0_i7Eeu5nU0_raw.srt @@ -0,0 +1,2252 @@ +1 +00:00:20,720 --> 00:00:23,920 +ال .. ال .. هاي المحاضرة التالتة بال financial + +2 +00:00:23,920 --> 00:00:29,040 +environments أو ال investment environment يعني + +3 +00:00:29,040 --> 00:00:33,960 +البيئة المالية فاحنا بنحكي بال separation of + +4 +00:00:33,960 --> 00:00:37,120 +ownership separation of ownership بتعني اللي هو + +5 +00:00:37,120 --> 00:00:42,640 +الفصل الإداري أو الفصل بين المستويات الإداريةو + +6 +00:00:42,640 --> 00:00:46,760 +just to remind you انذكركم ان المرة الفاتة the + +7 +00:00:46,760 --> 00:00:51,400 +previous meeting we talked about the separation of + +8 +00:00:51,400 --> 00:00:57,140 +ownership الفصل في المستويات الإدارية for instance + +9 +00:00:57,140 --> 00:01:04,040 +عند ال board of directors ال board of directors is + +10 +00:01:04,040 --> 00:01:09,720 +being elected by the owners okay electedثم مجلد + +11 +00:01:09,720 --> 00:01:15,200 +المديرين اختاروا الاختصارات الاختصارات + +12 +00:01:15,200 --> 00:01:25,900 +E1 E2 E3 E4 ثم الموظفين الآن باعتبار القوانين + +13 +00:01:25,900 --> 00:01:26,340 +الجديدة + +14 +00:01:29,640 --> 00:01:35,320 +in the separation of ownership the departments or + +15 +00:01:35,320 --> 00:01:36,740 +let's say the board of directors should be + +16 +00:01:36,740 --> 00:01:39,560 +separated from the executive يعني مجلس الإدارة + +17 +00:01:39,560 --> 00:01:44,280 +لازم يكون منفصل عن المدرأ ال managers كمان ال + +18 +00:01:44,280 --> 00:01:48,380 +managers be careful the managers shouldn't have + +19 +00:01:48,380 --> 00:01:52,260 +executive functions + +20 +00:01:52,940 --> 00:01:55,280 +مش لازم يكون عندهم executive functions هذه صارت + +21 +00:01:55,280 --> 00:01:59,000 +أخر إشي يعني بعد 2007 صار ضروري المدرة اللي + +22 +00:01:59,000 --> 00:02:02,660 +بيشاركوا في إدارة الشركة في مجلس الإدارة يعني لو + +23 +00:02:02,660 --> 00:02:06,600 +كان عند أنا هنا مدرة managers هدول ال managers + +24 +00:02:06,600 --> 00:02:09,320 +should be separated from the executives مش لازم + +25 +00:02:09,320 --> 00:02:13,500 +يدخلوا في إدارة الشركة بيحطوا هم بس ال strategies + +26 +00:02:13,500 --> 00:02:19,040 +بيحطوا ال strategias okay وما بيدخلوش في المهمة + +27 +00:02:19,040 --> 00:02:25,270 +التنفيذية للشركة ليش؟ عشانحتى المدرة نفسهم لما + +28 +00:02:25,270 --> 00:02:28,730 +بيحطوا ال strategies و يطلبوا من ال executive + +29 +00:02:28,730 --> 00:02:33,150 +المدراء التنفيذي ينافذوا هذه يظل المدرة دورهم دور + +30 +00:02:33,150 --> 00:02:37,850 +رقابي على ال executives و إلا لو كانوا تدخلوا فيها + +31 +00:02:37,850 --> 00:02:41,550 +فلو كان في خطأ ممكن يخبوه so this is why should be + +32 +00:02:41,550 --> 00:02:46,650 +separation between the board of directors and the + +33 +00:02:46,650 --> 00:02:50,490 +executivesand in the same vein فى نفس الطريقة + +34 +00:02:50,490 --> 00:02:54,370 +الناس الموجودين فى ال board of directors مش لازم + +35 +00:02:54,370 --> 00:03:01,750 +يتدخلوا فى أعمال المدرق okay exactly يعني هم they + +36 +00:03:01,750 --> 00:03:04,050 +are setting the strategies بيحطوا ال strategies + +37 +00:03:04,050 --> 00:03:07,910 +and they are observing what the executive doing + +38 +00:03:07,910 --> 00:03:12,750 +يعني هم بيحطوا بيطلعوا بيشوفوا بيراقبوا إيش ال + +39 +00:03:12,750 --> 00:03:17,150 +executive بيسووا المدرق التنفيذيينand in the same + +40 +00:03:17,150 --> 00:03:20,950 +.. in the same way كمان هدول ال executives هدول + +41 +00:03:20,950 --> 00:03:24,490 +الناس الموجودين بال .. بالمديرات التنفيذية مهمتهم + +42 +00:03:24,490 --> 00:03:29,890 +تنفيذ العمل حسب what is the strategy is saying حسب + +43 +00:03:29,890 --> 00:03:33,630 +الاستراتيجية شو بتحكي يعني بدكون هم عملهم مرتبط + +44 +00:03:33,630 --> 00:03:36,970 +بالاستراتيجية مابتدخلش ال board of directors + +45 +00:03:36,970 --> 00:03:40,650 +بشغلهم okay كمان هم مابتدخلوا في ال .. في ال board + +46 +00:03:40,650 --> 00:03:43,270 +of directors ال board of directors هم أعضاء مجلس + +47 +00:03:43,270 --> 00:03:44,470 +الإدارة did you write it + +48 +00:03:50,700 --> 00:03:54,840 +الboard of directors هم أعضاء مجلس إدارة كمان مرة + +49 +00:03:54,840 --> 00:03:59,020 +هدول أعضاء مجلس إدارة بس بيحطوا الاستراتيجيات they + +50 +00:03:59,020 --> 00:04:02,920 +are setting the headlines البقوس العامة للشركة + +51 +00:04:02,920 --> 00:04:07,720 +okay و بعدين they send it off to the executives + +52 +00:04:07,720 --> 00:04:10,560 +المدرع التنفيذيين المدرع التنفيذيين ما عليهم إلا + +53 +00:04:10,560 --> 00:04:12,740 +يقوموا بتنفيذ هذه المهم okay + +54 +00:04:15,010 --> 00:04:19,370 +لكن شو اللي صار؟ اللي صار انه المدرأ التنفيذيين ال + +55 +00:04:19,370 --> 00:04:24,030 +executives or the executive managers صاروا they + +56 +00:04:24,030 --> 00:04:26,730 +prefer their personal objectives rather than their + +57 +00:04:26,730 --> 00:04:31,750 +strategies صاروا يفضلوا مصالحهم الشخصية على مصالح + +58 +00:04:31,750 --> 00:04:37,750 +الشركة okay so what is the solution? the corporate + +59 +00:04:37,750 --> 00:04:40,920 +governanceال .. ال .. الحل هو وجود ال corporate + +60 +00:04:40,920 --> 00:04:44,340 +governance اللي هو الحوكمة اللي احنا بنحكي فيها + +61 +00:04:44,340 --> 00:04:49,360 +بال corporate governance طيب شو ال corporate + +62 +00:04:49,360 --> 00:04:53,540 +governance؟ what it means الحوكمة؟ اه تفضلوا + +63 +00:04:53,540 --> 00:05:00,320 +الحوكمة شو معناها؟ what it means governance؟ يارا + +64 +00:05:00,320 --> 00:05:05,480 +نترك الإجابة لكم اه تفضلوا احكي بالعربي + +65 +00:05:10,410 --> 00:05:15,210 +صح؟ صح؟ يعني هي عبارة عن ال rules, regulations + +66 +00:05:15,210 --> 00:05:19,490 +that organize the relationship between the .. the + +67 +00:05:19,490 --> 00:05:24,010 +owners and the .. the executives or the board of + +68 +00:05:24,010 --> 00:05:28,650 +directors مين عنده كمان شغلة؟ okay اتفضلي + +69 +00:05:34,440 --> 00:05:36,800 +صحيح؟ و أيضا هي من القوانين اللي تقلد المعايشة + +70 +00:05:36,800 --> 00:05:41,220 +التعداد البارية لكتير المستخدمين. Okay صح okay The + +71 +00:05:41,220 --> 00:05:45,220 +set of laws and decisions to achieving quality and + +72 +00:05:45,220 --> 00:05:47,900 +excellence in performance by selecting the + +73 +00:05:47,900 --> 00:05:50,960 +operation method to achieve the plans and + +74 +00:05:50,960 --> 00:05:55,400 +objectivesOkay so according to your definition it + +75 +00:05:55,400 --> 00:05:59,280 +means the executives are free to select the + +76 +00:05:59,280 --> 00:06:04,720 +policies or the how to transfer the transactions + +77 +00:06:04,720 --> 00:06:09,660 +into strategies يعني خلينا بي .. إيش اللي بيصير؟ + +78 +00:06:09,660 --> 00:06:14,260 +هدول بحطوا ال strategies okay هدول اللي هو ال + +79 +00:06:14,260 --> 00:06:18,220 +executives they translate strategies into actions + +80 +00:06:19,180 --> 00:06:22,560 +يعني بيحولوا ال استراتيجيات إلى أفعال okay into + +81 +00:06:22,560 --> 00:06:27,540 +actions these actions should be linked with the + +82 +00:06:27,540 --> 00:06:32,080 +strategy لازم يكون مرتبطة بالاستراتيجيةOkay for + +83 +00:06:32,080 --> 00:06:35,640 +instance على سبيل المثال the main business + +84 +00:06:35,640 --> 00:06:40,020 +strategy of the firm is to maximize the + +85 +00:06:40,020 --> 00:06:45,020 +shareholder firms or to maximize the firm's value + +86 +00:06:45,020 --> 00:06:48,500 +يعني الاستراتيجية الأساسية اللي هو maximize firm + +87 +00:06:48,500 --> 00:06:54,790 +valueيعني تعظيم قيمة المنشأة تعظيم قيمة المنشأة + +88 +00:06:54,790 --> 00:06:58,370 +هذا الاستراتيجية الأساسية now the executive asking + +89 +00:06:58,370 --> 00:07:03,030 +themselves what are the actions should be taken to + +90 +00:07:03,030 --> 00:07:08,890 +translate the value يعني ما هي الوسائل اللي احنا + +91 +00:07:08,890 --> 00:07:12,570 +لازم نستخدمها عشان حتى نقوم بتحقيق الاستراتيجية + +92 +00:07:12,570 --> 00:07:18,170 +okay this is a big question okay for instance if + +93 +00:07:18,170 --> 00:07:23,440 +we talk about appleand you know apple شركة apple + +94 +00:07:23,440 --> 00:07:28,920 +so the apple the strategy of apple is to maximize + +95 +00:07:28,920 --> 00:07:35,600 +the fan value now this question is sent off to the + +96 +00:07:35,600 --> 00:07:40,260 +executives لنبعت لل executive and the executives + +97 +00:07:40,260 --> 00:07:46,620 +sets the actions هم دورهم يشتغلوا طيب ايش هيسوي ال + +98 +00:07:46,620 --> 00:07:49,840 +executive السؤال الكبير ان هم بدهم يعزموا ال fan + +99 +00:07:49,840 --> 00:07:54,590 +valueطيب إيش أبل لازم تسوي؟ ال managers بتاعون + +100 +00:07:54,590 --> 00:07:57,430 +أبل، شو لازم يعملوا؟ المدراء التنفيذيين، عشان + +101 +00:07:57,430 --> 00:08:01,970 +يحققوا هذا الهدف؟ حاولوا يعملوا .. okay how؟ خلينا + +102 +00:08:01,970 --> 00:08:08,510 +.. okay okay they follow the rules of the board of + +103 +00:08:08,510 --> 00:08:11,190 +directors but how they transfer these into + +104 +00:08:11,190 --> 00:08:14,910 +actions؟ يعني هل عملوا مثلا ال iPhone 4 و ال + +105 +00:08:14,910 --> 00:08:19,010 +iPhone 5؟ شو الجديد اللي صار بال .. okay إذا انت + +106 +00:08:19,010 --> 00:08:25,280 +competition competesthe word regarding the product + +107 +00:08:25,280 --> 00:08:29,180 +of the iPhone يعني مثلا بدهم يضيفوا يعملوا + +108 +00:08:29,180 --> 00:08:32,960 +developments على ال iPhone هذا ال developments + +109 +00:08:32,960 --> 00:08:35,880 +بيكون هذا ال developments يعني على مستوى العالم + +110 +00:08:35,880 --> 00:08:40,060 +بحيث كل ما زادوا ال developments تبعت ال iPhone + +111 +00:08:40,060 --> 00:08:44,600 +اللي بيصير ال customer بيزيد شراءه لهذه ال iPhones + +112 +00:08:44,600 --> 00:08:50,150 +هتزيد الأرباح هتصير زيادة من ال maximize valueOkay + +113 +00:08:50,150 --> 00:08:53,870 +فهم بيسيروا المهندسين الموجودين هان و ال marketing + +114 +00:08:53,870 --> 00:08:56,990 +و كلهم بيشتغلوا مع بعض how to improve the quality + +115 +00:08:56,990 --> 00:09:01,630 +and the services of the iphone 5 تمام ايش ال + +116 +00:09:01,630 --> 00:09:04,630 +services ايش ال facilities كلها فبالتالي ال board + +117 +00:09:04,630 --> 00:09:08,910 +of directors بس حطوا general strategies وضل هدول + +118 +00:09:08,910 --> 00:09:13,850 +دورهم how to do this كيف ان هم يشتغلوا و يحققوا + +119 +00:09:13,850 --> 00:09:19,790 +النتائج بتاعة ال strategiesهل ال strategy .. هدول + +120 +00:09:19,790 --> 00:09:23,850 +executives بعد ما يحققوا هاي الأهداف ال objectives + +121 +00:09:23,850 --> 00:09:28,830 +بيجي دول ال board of directors to see .. بيشوفوا + +122 +00:09:28,830 --> 00:09:33,350 +هل هدول حققوا what we are saying or not؟ هل حققوا + +123 +00:09:33,350 --> 00:09:37,980 +إيش اللي إحنا بنحكي فيه ولا ماحققوش؟فصار دورهم ال + +124 +00:09:37,980 --> 00:09:42,920 +board of directors is like auditing يتأكدوا من ان + +125 +00:09:42,920 --> 00:09:49,680 +ال executives بيشتغلوا حسب ما يحتاج ال time ايش + +126 +00:09:49,680 --> 00:09:53,620 +كمان له علاقة ال corporate governance انت كنت بدك + +127 +00:09:53,620 --> 00:09:58,780 +تحكي okay it is the act of governing is related to + +128 +00:09:58,780 --> 00:10:05,630 +decision that defineexpectations توقعت يعني it + +129 +00:10:05,630 --> 00:10:09,090 +consists of either a separate process of the part + +130 +00:10:09,090 --> 00:10:13,270 +of the decision making or leadership process okay + +131 +00:10:13,270 --> 00:10:16,310 +so هي زي ما اتفضلتها انه يالي بنعمل separation في + +132 +00:10:16,310 --> 00:10:19,610 +ال leadership ان يكون هدول ال board of directors + +133 +00:10:19,610 --> 00:10:22,790 +هم بيبحث بيحطوا ال strategies and they are + +134 +00:10:22,790 --> 00:10:25,410 +responsible on this و بعدين ال leadership + +135 +00:10:25,410 --> 00:10:31,010 +الموجودين في ال executive level just to focus on + +136 +00:10:31,010 --> 00:10:35,040 +leading the businessOkay how we can do the + +137 +00:10:35,040 --> 00:10:39,660 +corporate governance it should be transparency you + +138 +00:10:39,660 --> 00:10:42,340 +know what it means transparency transparency it + +139 +00:10:42,340 --> 00:10:50,640 +means الوضوح الشفافية الشفافية يعني مثلا ال board + +140 +00:10:50,640 --> 00:10:54,040 +of directors يكون واضحين الاستراتيجية تبعتهم واضحة + +141 +00:10:54,040 --> 00:10:58,680 +ال actions بتاعة ال executives لازم يكون واضحة + +142 +00:10:58,680 --> 00:11:04,250 +فبسموها transparencyسمعتوها transparency فمن أحد + +143 +00:11:04,250 --> 00:11:08,270 +مبادئ ال corporate governance أنه ال executives هم + +144 +00:11:08,270 --> 00:11:14,670 +بنفذوا ال استراتيجيات تكون هذه الاستراتيجيات واضحة + +145 +00:11:14,670 --> 00:11:18,730 +and linked with these strategies تكون فيها وضوح مش + +146 +00:11:18,730 --> 00:11:24,090 +فيها غمض okay why because sometimes executives + +147 +00:11:24,090 --> 00:11:30,010 +they try to achieve their own objectivesبدهم + +148 +00:11:30,010 --> 00:11:33,550 +يحققوا أهدافهم they should declare that these + +149 +00:11:33,550 --> 00:11:37,050 +objectives are linked with the strategies لازم + +150 +00:11:37,050 --> 00:11:40,930 +تكونوا واضحين أن هذه الأهداف هي تابعة لستراتيجية + +151 +00:11:40,930 --> 00:11:47,470 +المنشأة okay فهذه شغل اسمها transparency because + +152 +00:11:47,470 --> 00:11:51,830 +the failure of applying transparencyعارفين شو بقى + +153 +00:11:51,830 --> 00:11:53,870 +because of the failure of applying transparency + +154 +00:11:53,870 --> 00:11:58,130 +بسبب ان هم مافيش له الشركات المتقدمة الشركات + +155 +00:11:58,130 --> 00:12:00,590 +الأوروبية و الأمريكية مافيش لتقديم ال transparency + +156 +00:12:00,590 --> 00:12:06,590 +تطبيقها صار في إفلاس لكتير شركات okay أهم هذه + +157 +00:12:06,590 --> 00:12:10,470 +الشركات كانت word.com okay or worldwide company + +158 +00:12:10,470 --> 00:12:15,590 +ثاني أهم شركة في العالم أكبر شركة كانت تنتج الطاقة + +159 +00:12:15,590 --> 00:12:20,630 +في العالم هي شركة Enronو انا ب .. يعني I recommend + +160 +00:12:20,630 --> 00:12:28,110 +you to read why Enron فال؟ ليش Enron خسره؟ خسرت + +161 +00:12:28,110 --> 00:12:30,650 +Enron بسبب they .. they failed to apply the + +162 +00:12:30,650 --> 00:12:34,250 +corporate governance خسره لإن هما ما طبقوش ال + +163 +00:12:34,250 --> 00:12:37,930 +corporate governance طبعا أنا طلبت منكوا تقرؤوا + +164 +00:12:37,930 --> 00:12:46,510 +الكلام هذا، في حد عرف ليش Enron خسرت؟ ليش؟ في صفحه + +165 +00:12:46,510 --> 00:12:53,060 +تمانيةin page eight انا حكيت انهم فشلوا في تطبيق + +166 +00:12:53,060 --> 00:12:56,380 +ال corporate governance how they fail to apply + +167 +00:12:56,380 --> 00:12:57,260 +corporate governance + +168 +00:13:02,260 --> 00:13:06,120 +حكينا من أحد مبادئ ال transparency أحد مبادئ ال .. + +169 +00:13:06,120 --> 00:13:09,880 +ال .. ال corporate governance ال transparency و + +170 +00:13:09,880 --> 00:13:12,240 +كمان اللي هو separation of the ownership و + +171 +00:13:12,240 --> 00:13:15,400 +separation in the .. in the management ليش ال + +172 +00:13:15,400 --> 00:13:20,380 +Enron مطبخوش ال .. ال .. ال governance شريك صحيح + +173 +00:13:20,380 --> 00:13:23,480 +وبالتالي they .. they .. they lose a lot of money + +174 +00:13:23,480 --> 00:13:27,400 +عارفين كام خسائر ال Enron؟ كام؟ خسائر شركة Enron + +175 +00:13:27,400 --> 00:13:30,540 +مجموعة ما تنفقه الولايات المتحدة الأمريكية على + +176 +00:13:30,540 --> 00:13:36,570 +عالم التالت كلهاشفتوا قداش؟ شركة Enrol لوحدها لما + +177 +00:13:36,570 --> 00:13:40,270 +خسرت لما صار عندهم drop خسرت بمجموع ما تنفقه + +178 +00:13:40,270 --> 00:13:44,550 +الولايات المتحدة الأمريكية على عالم التالت كله طيب + +179 +00:13:44,550 --> 00:13:50,330 +السبب الرئيسي لخسرتهم أحد أهم مبادئ ال corporate + +180 +00:13:50,330 --> 00:13:53,630 +governance لازم يكون في شغل اسمها auditing عارفين + +181 +00:13:53,630 --> 00:14:01,210 +شو معنى auditing؟ رقابة okay الرقابة نوعينyes we + +182 +00:14:01,210 --> 00:14:03,510 +have internal auditing and we have external + +183 +00:14:03,510 --> 00:14:08,810 +auditing fine so the internal auditors they are + +184 +00:14:08,810 --> 00:14:12,910 +menu plates in the financial statements كانوا + +185 +00:14:12,910 --> 00:14:17,930 +يتلاعبوا في إيش في ال financial statements and + +186 +00:14:17,930 --> 00:14:22,570 +they hire a consultations or a consultants from a + +187 +00:14:22,570 --> 00:14:25,550 +particular company let's say Merrill Lynch + +188 +00:14:28,340 --> 00:14:31,520 +شركة Merrill Lynch شركة Merrill Lynch هي اكبر من + +189 +00:14:31,520 --> 00:14:38,740 +اكبر الشركات المالية في العالم وكانوا عاملين اتفاق + +190 +00:14:38,740 --> 00:14:46,420 +مع Anderson شركة Anderson كانت + +191 +00:14:46,420 --> 00:14:55,400 +متفقة مع شركة Enron يقدموا شغلتين احفظوهم Anderson + +192 +00:14:56,920 --> 00:15:01,360 +Anderson تدقيق .. تدقيق محاسب okay يخدموا شغلتين + +193 +00:15:01,360 --> 00:15:06,100 +consultation and + +194 +00:15:06,100 --> 00:15:09,940 +auditing consultation + +195 +00:15:09,940 --> 00:15:16,660 +إيش معناها استشارات يخدموهم استشارات okay و في نفس + +196 +00:15:16,660 --> 00:15:21,660 +الوقت إيش يقدمولهم auditing رقابة طب بنفع إيش + +197 +00:15:21,660 --> 00:15:25,590 +رأيكم؟يعني بينفع انه انا اعطيك استشارات و في نفس + +198 +00:15:25,590 --> 00:15:30,670 +الوقت انه انا اعمل رقابة عليك؟ اذا كان في خطأ + +199 +00:15:30,670 --> 00:15:35,110 +بيكون خطأ من وين؟ من ال consultation بالظبط فإذا + +200 +00:15:35,110 --> 00:15:37,810 +كان في خطأ فإيش تسوي الشركة Anderson؟ Anderson + +201 +00:15:37,810 --> 00:15:43,610 +تروح تغطي على الأخطاء صارت الأخطاء تكبر تكبر لما + +202 +00:15:43,610 --> 00:15:46,890 +صار فيه فياليار كبير فلما أذيت ال corporate + +203 +00:15:46,890 --> 00:15:55,760 +governance حكتهم لأ لازم يكون في separationفصل بين + +204 +00:15:55,760 --> 00:16:00,500 +ال auditing services وبين ال consultation services + +205 +00:16:00,500 --> 00:16:05,040 +يعني + +206 +00:16:05,040 --> 00:16:09,180 +الشركة اللي بتعمل auditing هي شركة غير اللي بتعمل + +207 +00:16:09,180 --> 00:16:14,000 +consultation وصنوا قانون هذا القانون كتير مهم + +208 +00:16:14,000 --> 00:16:17,080 +القانون + +209 +00:16:17,080 --> 00:16:22,360 +المهم اللي عملوه اللي هو Sarpenes-Oxley Act + +210 +00:16:25,430 --> 00:16:29,910 +Sarbanes Oxley Act اللي هي بيحكي ان it should be + +211 +00:16:29,910 --> 00:16:36,190 +separated between the consultancy services and the + +212 +00:16:36,190 --> 00:16:40,330 +auditing services يعني الخدمات بتاعة التدقيق لازم + +213 +00:16:40,330 --> 00:16:43,490 +تنفصل عن خدمات الاستشارات المالية و الفنية و + +214 +00:16:43,490 --> 00:16:46,950 +الإدارية لأنه مابنفع انه انا في نفس اللحظة اقدم + +215 +00:16:46,950 --> 00:16:49,290 +خدمات استشارية و في نفس اللحظة اعمل رقابة على + +216 +00:16:49,290 --> 00:16:55,120 +الشركة بيصير ايش publications بظبطشطبعا هدول كانوا + +217 +00:16:55,120 --> 00:16:57,200 +هم ال .. ال Arthur Anderson هم المسؤولين عن + +218 +00:16:57,200 --> 00:17:00,540 +المشكلة هذه بتتعاون مع مين؟ بتتعاون مع التدقيق + +219 +00:17:00,540 --> 00:17:03,260 +الداخل في الشركة و صاروا يتلعبوا في الحسابات و + +220 +00:17:03,260 --> 00:17:08,320 +يظهروها حسابات جيدة لما بدأت تصير خسائر في هذه + +221 +00:17:08,320 --> 00:17:12,720 +الشركة okay؟ الكويس أنه كتير تقرأوا عن هذا ال .. + +222 +00:17:12,720 --> 00:17:17,140 +تجربة .. تجربة Enron و .. و .. و السبب أنه صار في + +223 +00:17:17,140 --> 00:17:21,680 +stress on the corporate governance طبعا؟ في حد + +224 +00:17:21,680 --> 00:17:22,280 +عنده سؤال؟ + +225 +00:17:25,450 --> 00:17:28,450 +واضح corporate governance معروف ايش معناها + +226 +00:17:28,450 --> 00:17:33,190 +corporate ethics corporate ethics اللي هو أخلاقية + +227 +00:17:33,190 --> 00:17:42,630 +المهنة اللي هو كيف تطبق أخلاقية المهنة مين + +228 +00:17:42,630 --> 00:17:45,350 +يعطيلي أنثى على تطبيق أخلاقية المهنة for instance + +229 +00:17:45,350 --> 00:17:46,530 +corporate ethics + +230 +00:17:54,990 --> 00:17:59,870 +transparency .. transparency okay ethics يعني مثلا + +231 +00:17:59,870 --> 00:18:08,130 +لو شركة من الشركات كان عندي انا ال .. ال executive + +232 +00:18:08,130 --> 00:18:12,510 +.. ال executives هتقبل .. انا مابديش واحد منهم ال + +233 +00:18:12,510 --> 00:18:19,830 +executiveو .. و في executive A is .. is highly + +234 +00:18:19,830 --> 00:18:25,270 +activated و executive B ماعندوش نشاط فمن ناحية + +235 +00:18:25,270 --> 00:18:30,550 +ethics أنه هذا is promoted and this .. the .. the + +236 +00:18:30,550 --> 00:18:35,450 +company may asking this to improve his skillsيعني + +237 +00:18:35,450 --> 00:18:38,150 +من الطبيعي أن أكون في عندي .. لو عندي مديرين في + +238 +00:18:38,150 --> 00:18:41,470 +الشركة، مدير بيشتغل منيح و مدير بيشتغلش منيح، فمن + +239 +00:18:41,470 --> 00:18:45,850 +الغلط أنه أنا أشجع المدير اللي .. اللي ما بيشتغل، + +240 +00:18:45,850 --> 00:18:49,090 +فلازم يكون في عندي وضوح، لازم يكون عندي ethics، + +241 +00:18:49,090 --> 00:18:52,790 +علاقات ال ethics في الشركة، أخلاقيات المهنة بتتطلب + +242 +00:18:52,790 --> 00:18:58,880 +أنه أنا أكون fair مع ال executivesكمان من أخلاقية + +243 +00:18:58,880 --> 00:19:02,380 +المهنة if they .. the executives doing well إذا + +244 +00:19:02,380 --> 00:19:05,620 +كانوا عملوا شغلات للمنشأة منيحة و قد تالي I should + +245 +00:19:05,620 --> 00:19:09,260 +compensate them لازم أنا إيش؟ أعملهم compensation + +246 +00:19:09,260 --> 00:19:11,980 +كيف ال compensation؟ ال compensation ممكن using + +247 +00:19:11,980 --> 00:19:16,400 +the option rights option rights معناها أنه أنا + +248 +00:19:16,400 --> 00:19:21,180 +أخليهم يلهم حقوق لشراء السهم في الشركة أكيد + +249 +00:19:21,180 --> 00:19:26,520 +قرأتوها بال .. بالكتاب اللي اسمها option rights + +250 +00:19:28,120 --> 00:19:33,440 +option rights option rights تعني لو كان سعر مثلا + +251 +00:19:33,440 --> 00:19:37,900 +بالتل، عارفين شركة بالتل؟ شركة الاتصالات، لو كان + +252 +00:19:37,900 --> 00:19:44,740 +سعرها مثلاOkay ستة و نص دولار و كان عندي مدير حقق + +253 +00:19:44,740 --> 00:19:49,700 +نتائج غير طبيعية لأنه ناشط و بيشتغلوا منيح و كذا + +254 +00:19:49,700 --> 00:19:52,960 +فكويس من ال ethics انه انا ايش اعمله compensation + +255 +00:19:52,960 --> 00:19:56,980 +يعني اشجعه فبنشجعه عن طريق شغل اسمه option rights + +256 +00:19:56,980 --> 00:20:01,550 +ال option rights بعدين بحكي للمدير okayال price + +257 +00:20:01,550 --> 00:20:08,950 +now is 6.5 احنا هنعطيك right is option right to + +258 +00:20:08,950 --> 00:20:14,190 +buy this stock at two dollar نعطيك حق تشتري هذا + +259 +00:20:14,190 --> 00:20:18,430 +السهم ب two dollar كويس يعني هو اصلا لو بدوش يدفع + +260 +00:20:18,430 --> 00:20:24,330 +two dollar هيكون ربحان كام four and half أربعة و + +261 +00:20:24,330 --> 00:20:31,610 +نصso he has a right to sell his option عارفين كلام + +262 +00:20:31,610 --> 00:20:34,990 +هذا بال finance؟ he has a right to sell his option + +263 +00:20:34,990 --> 00:20:38,070 +يعني مثلا لو إجت الجامعة الإسلامية حكتله حكت + +264 +00:20:38,070 --> 00:20:43,110 +المدرسين معكم حق تشتريوا هذا ال laptop حق تشتريوا + +265 +00:20:43,110 --> 00:20:49,400 +ال laptop هذا ب 100 دولار كام؟ 100 دولارحقوا 500 + +266 +00:20:49,400 --> 00:20:53,480 +دولار طيب في ناس انا عندي laptop I don't need this + +267 +00:20:53,480 --> 00:21:00,120 +فاش بسوي I use my right to sell the laptop يعني + +268 +00:21:00,120 --> 00:21:02,100 +انا بستخدم حقي في بيع ال laptop + +269 +00:21:05,180 --> 00:21:08,900 +أحد أي أحد في السوق موجود موجودين option rights + +270 +00:21:08,900 --> 00:21:11,940 +موجودة في السوق المالي فببيع ال laptop سعره في ال + +271 +00:21:11,940 --> 00:21:15,240 +market خمس مائة دولار أنا معايا option rights بمية + +272 +00:21:15,240 --> 00:21:19,680 +دولار أشتريه فأنا باخد الفرق بينهم اللي هو four + +273 +00:21:19,680 --> 00:21:23,060 +hundred dollar أو الحل الآخر بدفع المية دولار و + +274 +00:21:23,060 --> 00:21:25,540 +باخد السهم أو الخمس مائة دولار أو ال laptop أو + +275 +00:21:25,540 --> 00:21:30,330 +الخمس مائة دولار هى بيسموها إيش option rightsطبعا + +276 +00:21:30,330 --> 00:21:33,890 +عدم تطبيق هذه الأمور و عدم تطبيق ال corporate + +277 +00:21:33,890 --> 00:21:38,090 +governance عملت كتير scandals شايفين هذه scandals + +278 +00:21:38,090 --> 00:21:41,710 +examples of scandals من ال .. اللي بيسموها الفضائح + +279 +00:21:41,710 --> 00:21:47,190 +الإدارية و الفضائح المحاسبيةيعني مش بس إنا إحنا + +280 +00:21:47,190 --> 00:21:49,950 +موجودة كمان في أوروبا و في أمريكا صار عندهم فضائح + +281 +00:21:49,950 --> 00:21:56,770 +كبيرة و كلفت الشركات مبالغ ضخمة حتى ي .. يعالجوا + +282 +00:21:56,770 --> 00:22:01,630 +هاي المواضيع و بالأخير انه صار في tightness in the + +283 +00:22:01,630 --> 00:22:06,730 +applying the corporate governance صار في تشدد في + +284 +00:22:06,730 --> 00:22:09,130 +تطبيق ال corporate governance و في تطبيق ال ethics + +285 +00:22:09,130 --> 00:22:12,470 +في تطبيق إيش ال ethics سنعطيكم مثال على ال ethics + +286 +00:22:13,970 --> 00:22:17,510 +في ال ethics مثلا اللي تتطبق في الشركات لو احنا + +287 +00:22:17,510 --> 00:22:20,650 +عندنا two managers هذه صارت جديدة في أوروبا يعني + +288 +00:22:20,650 --> 00:22:24,430 +2011 2012 لو عندنا two managers جايين بدهم يتقدموا + +289 +00:22:24,430 --> 00:22:28,030 +للشركة ب .. ب .. بأعمال واحد is from the middle + +290 +00:22:28,030 --> 00:22:32,510 +east and one is Americanواحد من الشرق الأوسط و + +291 +00:22:32,510 --> 00:22:35,890 +واحد من أمريكا فهم إيش هيفضله؟ هيفضله من بتاع + +292 +00:22:35,890 --> 00:22:39,210 +الولايات .. ال united states ف according to the + +293 +00:22:39,210 --> 00:22:43,770 +ethical codes احفظوها ethical codes ethical code + +294 +00:22:43,770 --> 00:22:48,090 +ethical + +295 +00:22:48,090 --> 00:22:53,070 +code ال ethical code هي ال .. ال .. ال .. المفاهيم + +296 +00:22:53,070 --> 00:22:57,110 +الأخلاقية في الشركاتit suppose there is no + +297 +00:22:57,110 --> 00:23:00,090 +differentiation between people from the united + +298 +00:23:00,090 --> 00:23:03,170 +states and people from the middle east مافيش + +299 +00:23:03,170 --> 00:23:07,970 +تفارقة okay it depends on their quality or in + +300 +00:23:07,970 --> 00:23:10,490 +their qualifications طيب نشوف عندنا مثلا في + +301 +00:23:10,490 --> 00:23:16,090 +الشركات لو كان تقدم رجل او ولاده او بنت to the + +302 +00:23:16,090 --> 00:23:18,830 +same function and both of them both of them have + +303 +00:23:18,830 --> 00:23:22,170 +the same qualifications which they prefer ladies + +304 +00:23:22,170 --> 00:23:29,100 +or menswe don't know so if they prefer mens over + +305 +00:23:29,100 --> 00:23:33,940 +ladies it means this is unethical behavior هذا إشي + +306 +00:23:33,940 --> 00:23:38,080 +غير أخلاقي okay another example if some people + +307 +00:23:38,080 --> 00:23:41,480 +living in a particular place and other people they + +308 +00:23:41,480 --> 00:23:44,980 +live in another place and the big manager is + +309 +00:23:44,980 --> 00:23:50,000 +living nearby one of them so he or she do prefer + +310 +00:23:50,000 --> 00:23:54,320 +another one this is against to the ethicsSo this + +311 +00:23:54,320 --> 00:23:57,340 +is ethical codes, this is why in some regulations + +312 +00:23:57,340 --> 00:24:00,900 +when you applying your forms they don't need you + +313 +00:24:00,900 --> 00:24:04,340 +to write down specific details about your .. your + +314 +00:24:04,340 --> 00:24:07,460 +.. your life or about your personal things يعني في + +315 +00:24:07,460 --> 00:24:11,640 +بعض الحالات الممكن مايطلبوش تكتب تب اسمكتكتب اسمك + +316 +00:24:11,640 --> 00:24:15,800 +بالطلب لكن لما تروح لللجنة اللى بدها تقابلك انه + +317 +00:24:15,800 --> 00:24:20,560 +بيعطوا رقم للطلب ال ethnicity عارفين شو معنى ال + +318 +00:24:20,560 --> 00:24:24,020 +ethnicity اللى العقية تبعتك your language و ال + +319 +00:24:24,020 --> 00:24:28,100 +religious they disappear this كلها بيخفوها و + +320 +00:24:28,100 --> 00:24:33,420 +بظهروا بس ال qualifications okay بعد ما يعملوا + +321 +00:24:33,420 --> 00:24:35,440 +filtering بتروح على ال interview و ال interview + +322 +00:24:35,440 --> 00:24:38,640 +they just concern of your qualifications if we + +323 +00:24:38,640 --> 00:24:42,610 +don't apply qualificationsit means we are breaking + +324 +00:24:42,610 --> 00:24:50,610 +or invading the ethical codes احنا بنعمل يعني خرق + +325 +00:24:50,610 --> 00:24:58,170 +وكسر لأخلاقية المهنة okay ف .. هذا السبب اللي .. + +326 +00:24:58,170 --> 00:25:03,010 +حتى اخر .. اخر .. اخر قضية صارت في فرنسا في هذا + +327 +00:25:03,010 --> 00:25:09,170 +الموضوع ان في بعض الفتيات تقدمنا ل .. للمحاكمةإن + +328 +00:25:09,170 --> 00:25:12,950 +هم أقل حظا من فتيات أخريات بتقدموا لل .. بيسموها + +329 +00:25:12,950 --> 00:25:16,570 +دي ال .. ال guesting services on the flights اللي + +330 +00:25:16,570 --> 00:25:20,630 +خدمات الضيافة في ال .. فهم بفضلوا فتيات عن أخريات + +331 +00:25:20,630 --> 00:25:29,950 +مضيفات فواحدة فرنسية قدمت للمحكمة الفرنسية انه why + +332 +00:25:29,950 --> 00:25:34,110 +you do prefer themإذا انتوا بتطلبوا الطول بدرجة + +333 +00:25:34,110 --> 00:25:36,670 +معينة إذا بتطلبوا الوزن بدرجة معينة إذا بتطلبوا + +334 +00:25:36,670 --> 00:25:39,430 +كذا كذا كذا and these qualifications and I have + +335 +00:25:39,430 --> 00:25:44,920 +these qualifications so why you don't select meحتى + +336 +00:25:44,920 --> 00:25:48,640 +even the .. the differentiation between ladies + +337 +00:25:48,640 --> 00:25:51,520 +themselves يعني التفريق حتى بين .. بين البنات + +338 +00:25:51,520 --> 00:25:55,280 +نفسهم فهذا بيسموه breaking the ethics ممكن كمان في + +339 +00:25:55,280 --> 00:25:59,120 +.. في .. بين الرجال نفسهم ممكن يكون انه اتنين رجال + +340 +00:25:59,120 --> 00:26:01,720 +تقدموا لمهنة واحد بيسكن في مكان و اخر بيسكن في + +341 +00:26:01,720 --> 00:26:07,070 +مكان اخرand they break the .. the thing is is to + +342 +00:26:07,070 --> 00:26:10,970 +applying the .. the ethical behavior or ethical + +343 +00:26:10,970 --> 00:26:14,330 +concentration why؟ اذا احنا طبقنا ال ethical + +344 +00:26:14,330 --> 00:26:17,650 +concentration على ال executives وعلى ال non + +345 +00:26:17,650 --> 00:26:21,370 +-executive حتى ال employees we should .. we .. we + +346 +00:26:21,370 --> 00:26:26,090 +keep the highly qualified people اذا .. اذا احنا + +347 +00:26:26,090 --> 00:26:28,610 +متطبق الكلام هذا نحتفظ في ال highly qualified + +348 +00:26:28,610 --> 00:26:32,460 +peopleإذا احنا we don't concern about your color, + +349 +00:26:33,580 --> 00:26:37,460 +okay you are male or female, your ethnicity, your + +350 +00:26:37,460 --> 00:26:40,040 +religious, other things, we don't care about this + +351 +00:26:40,040 --> 00:26:45,320 +and we do focus on your qualifications so we keep + +352 +00:26:45,320 --> 00:26:48,620 +the highly qualified people in our company، this + +353 +00:26:48,620 --> 00:26:50,800 +is what Americans, this is what the British, what + +354 +00:26:50,800 --> 00:26:52,640 +the Europeans argues + +355 +00:26:55,980 --> 00:26:58,580 +this is what I'm saying but I don't want to talk + +356 +00:26:58,580 --> 00:27:01,620 +about these things because we are online so they + +357 +00:27:01,620 --> 00:27:05,560 +think .. yes and they هو أصلا الفرنسية كانت she's + +358 +00:27:05,560 --> 00:27:11,820 +.. كانت .. كانت يعني سودا و لما تخدمت للوظيفة هم + +359 +00:27:11,820 --> 00:27:16,900 +they lay down her file lay down يعني راحوا + +360 +00:27:16,900 --> 00:27:24,230 +استبعدوا طلبهاI'm against this okay فحسب ال + +361 +00:27:24,230 --> 00:27:27,650 +ethical code حسب ال ethical code it doesn't matter + +362 +00:27:27,650 --> 00:27:29,990 +what is your color the matter things is your + +363 +00:27:29,990 --> 00:27:34,010 +qualifications بغض + +364 +00:27:34,010 --> 00:27:38,990 +النظر شو لونك شو لغتك شو شكلك الهدف الرئيسي إذا + +365 +00:27:38,990 --> 00:27:46,700 +احنا بدنا نعمل نعمل تقدم في الشركاتسلام؟ just for + +366 +00:27:46,700 --> 00:27:49,840 +qualifications if we fail to locate the qualified + +367 +00:27:49,840 --> 00:27:55,840 +people in their places it means it is the good + +368 +00:27:55,840 --> 00:27:59,760 +place to grow the corruption يعني هذا المكان + +369 +00:27:59,760 --> 00:28:05,220 +المناسب حتى الفساد ينمو okay so this is the things + +370 +00:28:05,220 --> 00:28:10,600 +okay هذا صعب كتير ربكم مش بسيط حتى على الأوروبيين + +371 +00:28:10,600 --> 00:28:12,780 +و على الأمريكان و على كل العالم الاشي مش بسيط مش + +372 +00:28:12,780 --> 00:28:20,010 +بس انا okayو يعني أبحاث كتير أثبتت أنه في ناس كتير + +373 +00:28:20,010 --> 00:28:23,590 +بيعملوا لل qualifications واحد من الأبحاث شاركت + +374 +00:28:23,590 --> 00:28:28,930 +أنا و professora في جامعة Manchester هذا البحث كان + +375 +00:28:28,930 --> 00:28:33,770 +بيحكي عن ال environment violation مرتبط في ال + +376 +00:28:33,770 --> 00:28:38,430 +corporate governance اللي .. اللي هو خرق ال .. + +377 +00:28:38,430 --> 00:28:41,050 +اللهم صلى الله عليه و سلم يا محمد .. خرق ال .. ال + +378 +00:28:41,050 --> 00:28:46,920 +.. الأخلاقيات المهنةواحد مصري مسلم كان يصلي في ال + +379 +00:28:46,920 --> 00:28:54,380 +.. أثناء العمل تمام؟ كان يصلي أثناء العمل فصارت + +380 +00:28:54,380 --> 00:28:57,200 +معاه مشكلة because أن هو مسلم they kicked him out + +381 +00:28:57,200 --> 00:29:02,580 +طردوه من العمل وبالتالي هذا ..نفس ال .. نفس ال .. + +382 +00:29:02,580 --> 00:29:06,040 +المشكلة بتصير انه في smoking area شوفوا ال .. طبعا + +383 +00:29:06,040 --> 00:29:09,920 +هو بنى القضية تبعته على ال justification حكالهم ان + +384 +00:29:09,920 --> 00:29:13,280 +smoking area people spending most of their time in + +385 +00:29:13,280 --> 00:29:16,760 +the smoking place يعني ممنوع التدخين داخل ال .. + +386 +00:29:16,760 --> 00:29:22,080 +داخل المكتب فبروحوا بيدخلوا خارج المكتب and they + +387 +00:29:22,080 --> 00:29:25,580 +spend from five to ten minutes I'm spending only + +388 +00:29:25,580 --> 00:29:29,440 +five minutes prayingإذا كنتوا تعقبوا عقبوا الناس + +389 +00:29:29,440 --> 00:29:33,640 +اللي بتدخن برا الشركة، بدخنوا، they smoking، ليش + +390 +00:29:33,640 --> 00:29:38,800 +أنتوا تعقبوني؟ فالقاضي حكم .. حكم معاه وكانت هذه + +391 +00:29:38,800 --> 00:29:42,940 +under the ethical considerations يعني صحيح مش + +392 +00:29:42,940 --> 00:29:46,540 +معايير للشركة أنه تحكي أنه ممنوع الصلاة، لأ + +393 +00:29:46,540 --> 00:29:49,300 +المعايير كانت تالية أنه طالما أنه في ناس بتدخن and + +394 +00:29:49,300 --> 00:29:51,780 +they spending five to ten minutes out of the + +395 +00:29:51,780 --> 00:29:57,960 +building, so this guyhe's doing his praying his + +396 +00:29:57,960 --> 00:30:01,780 +favorite things لأن هم ممكن بيعترفوش مثلا أنه هذا + +397 +00:30:01,780 --> 00:30:05,680 +دين خلاص his favorite things بيعمل شغلة اللي اللي + +398 +00:30:05,680 --> 00:30:09,500 +بيفضلها and they do this وبالتالي خسرت الشركة مبلغ + +399 +00:30:09,500 --> 00:30:15,180 +مش قليل حتى أنه يعوضوه + +400 +00:30:15,180 --> 00:30:18,700 +يعوضوه لأنه فعلا هي كانت breaking the ال ethical + +401 +00:30:18,700 --> 00:30:21,830 +considerationsفلما احنا نطبق ال ethical + +402 +00:30:21,830 --> 00:30:24,510 +consideration هيكون فيه تحسين في أداء الشركات، + +403 +00:30:24,510 --> 00:30:29,130 +هيكون في عند corporate governance واضحة ال ethics؟ + +404 +00:30:29,130 --> 00:30:31,510 +في عندكم أمثلة ممكن موجودة عندكم بال ethical + +405 +00:30:31,510 --> 00:30:38,390 +considerations؟ أمثلة بحياتكم، بالشركات، ممكن .. + +406 +00:30:38,390 --> 00:30:40,370 +طبعا لسه انتوا ما طلعتوش على بيئة العمل، بكرا + +407 +00:30:40,370 --> 00:30:43,950 +هتشوفوا بيئة العمل، هتشوفوا تفريق بال ethics، + +408 +00:30:43,950 --> 00:30:46,410 +هتشوفوا ان هذا this is ethics and this is non + +409 +00:30:46,410 --> 00:30:46,770 +ethics + +410 +00:31:01,390 --> 00:31:09,030 +Okay هذا against ethics هذا ضد ال .. ضد الأخلاق او + +411 +00:31:09,030 --> 00:31:13,950 +ممكن مثلا يكون يعني انسان + +412 +00:31:13,950 --> 00:31:20,790 +يكون بيعمل ب .. بجدية للشركة executives بيشتغل .. + +413 +00:31:20,790 --> 00:31:24,610 +he's working hard و لما يصير ال compensation يعمل + +414 +00:31:24,610 --> 00:31:28,660 +تعويض لشخص اخر مش ..مش sure المفروض أنه احنا بنعمل + +415 +00:31:28,660 --> 00:31:30,420 +evaluation لل people according to their + +416 +00:31:30,420 --> 00:31:34,080 +performance فنروح ممكن الشخص اللي ما بينتج نروح + +417 +00:31:34,080 --> 00:31:41,680 +نعطيه مكافئة و الشخص اللي بينتج ما نهمله okay طبعا + +418 +00:31:41,680 --> 00:31:48,040 +هذا بيكون breaking the ethical okay سمام + +419 +00:31:48,040 --> 00:31:54,280 +investment processإذا خلصنا احنا ال .. ال .. ال + +420 +00:31:54,280 --> 00:31:57,500 +relationship between the financial markets and the + +421 +00:31:57,500 --> 00:32:01,560 +economicsخلصنا العلاقة بين السوق المالي وبين ال + +422 +00:32:01,560 --> 00:32:07,900 +economics و الاقتصاد خلينا بس نذكركم فيهم هيك ع + +423 +00:32:07,900 --> 00:32:15,700 +السريع و زي ما ترجم اشي ترجم دور المعلومات + +424 +00:32:15,700 --> 00:32:18,840 +information rule كل ما كانت المعلومات available + +425 +00:32:18,840 --> 00:32:21,920 +للناس بيستطيعوا انهم يعملوا evaluation to the + +426 +00:32:21,920 --> 00:32:25,160 +business فال business اللي عنده شركات اللي عندها + +427 +00:32:25,160 --> 00:32:28,780 +good future prospectsthey have .. they have + +428 +00:32:28,780 --> 00:32:31,300 +opportunity to .. to compete in the markets يعني + +429 +00:32:31,300 --> 00:32:34,640 +اللي عندهم إمكانيات كبيرة ومعلومات واضحة ومستقبل + +430 +00:32:34,640 --> 00:32:38,000 +واضح هيكون عندهم إمكانية ينافسوا في السوق التاني + +431 +00:32:38,000 --> 00:32:41,340 +ال consumption timing ال consumption timing الناس + +432 +00:32:41,340 --> 00:32:46,120 +بت .. ببداية حياته بيكون ال .. ال earning أعلى من + +433 +00:32:46,120 --> 00:32:50,380 +ال consumption بيكون الدخل أعلى من الاستهلاك طيب + +434 +00:32:50,380 --> 00:32:54,000 +في المراحل المتأخرة بحياتهم بيصير العكس بيصير ال + +435 +00:32:54,000 --> 00:32:58,450 +consumption أعلى و ال earning أقلOkay لأن هو in + +436 +00:32:58,450 --> 00:33:03,150 +his or her late ages طب شو الحل؟ الحل أنه احنا لما + +437 +00:33:03,150 --> 00:33:07,750 +نكون عندنا ال .. ال .. ال .. the higher return so + +438 +00:33:07,750 --> 00:33:11,190 +we .. we have or we should invest for the lower + +439 +00:33:11,190 --> 00:33:14,990 +return يعني احنا بنستثمر ال higher return today + +440 +00:33:14,990 --> 00:33:19,810 +because our return in the future will be low هيكون + +441 +00:33:19,810 --> 00:33:25,200 +منخفض so the investment is importantallocation of + +442 +00:33:25,200 --> 00:33:27,820 +risk allocation of risk هو توزيع المخاطر + +443 +00:33:27,820 --> 00:33:31,220 +separation + +444 +00:33:31,220 --> 00:33:35,220 +of ownership and management هو الفصل بين الملاك + +445 +00:33:35,220 --> 00:33:40,920 +وبين الإدارة وكمان مش بس الفصل انه كل واحد يعرف + +446 +00:33:40,920 --> 00:33:45,080 +what is the task ال ال ال board of directors + +447 +00:33:45,080 --> 00:33:49,880 +setting the strategies okay and the executives + +448 +00:33:49,880 --> 00:33:53,400 +executives are translating the strategies into + +449 +00:33:53,400 --> 00:34:01,220 +actionsOkay بيحولوها ل .. يعني ل .. لأعمال لأفعال + +450 +00:34:01,220 --> 00:34:06,320 +okay corporate governance اللي هو الحوكمة and the + +451 +00:34:06,320 --> 00:34:09,080 +ethics اللي هو الأخلاقيات and I gave you examples + +452 +00:34:09,080 --> 00:34:11,760 +about the corporate governance and about the + +453 +00:34:11,760 --> 00:34:12,240 +ethics + +454 +00:34:15,150 --> 00:34:19,430 +Okay و هاي أمثلة على شركات صار فيها فضائح why? + +455 +00:34:19,810 --> 00:34:23,070 +because they don't apply corporate governance and + +456 +00:34:23,070 --> 00:34:26,930 +they don't apply the corporate ethics ماحققوش ال + +457 +00:34:26,930 --> 00:34:31,990 +corporate governance و ماحققوش ال ethics okay طبعا + +458 +00:34:31,990 --> 00:34:38,650 +واضح يا ..ش اسمك؟ ميه .. is it clear؟ انترجم okay + +459 +00:34:40,920 --> 00:34:46,480 +the investment process ال investment process it + +460 +00:34:46,480 --> 00:34:50,920 +consider the steps of doing investments يعني + +461 +00:34:50,920 --> 00:34:54,500 +الخطوات اللي احنا لازم نعملها حتى نعمل استثمار + +462 +00:34:54,500 --> 00:35:00,400 +خطوات عملية يعني لما نحكي عن ال asset ال + +463 +00:35:00,400 --> 00:35:05,820 +investment process هذه it's asking what are the + +464 +00:35:05,820 --> 00:35:10,980 +stepsOkay to do the business or to do the + +465 +00:35:10,980 --> 00:35:16,360 +investments one of the first step is asset + +466 +00:35:16,360 --> 00:35:20,120 +allocation asset allocation what it means asset + +467 +00:35:20,120 --> 00:35:26,860 +allocation اه توزيع الأصول او تخصيص الأصول زي ما + +468 +00:35:26,860 --> 00:35:32,460 +انتوا بتحكوا طيب how we can do this في أحد بعرف + +469 +00:35:32,460 --> 00:35:36,540 +how we can do this asset allocation أول خطوة احنا + +470 +00:35:36,540 --> 00:35:42,950 +بنقررهاوين نستفر asset allocation it means where + +471 +00:35:42,950 --> 00:35:47,850 +to invest أين سوف نستفر okay for instance we have + +472 +00:35:47,850 --> 00:35:54,410 +stocks we have bonds we have currencies we have + +473 +00:35:54,410 --> 00:35:59,030 +commodities we + +474 +00:35:59,030 --> 00:36:02,810 +have real estates etc + +475 +00:36:04,940 --> 00:36:08,760 +يعني عندنا أسهم، في عندنا سندات، في عندنا عملات، + +476 +00:36:08,760 --> 00:36:12,920 +في عندنا commodities اللي هم .. لأ commodities + +477 +00:36:12,920 --> 00:36:17,480 +معناها ال .. ال .. ال .. السلعب زي الحديد، انحاس، + +478 +00:36:17,480 --> 00:36:23,380 +الدهب، الفضة okay؟ real estate اللي هو العقارات + +479 +00:36:23,380 --> 00:36:29,160 +it's a try الأخرى، now the first decision you have + +480 +00:36:29,160 --> 00:36:34,590 +to takeis where to invest asset allocation to + +481 +00:36:34,590 --> 00:36:38,590 +invest in stock in bonds in currencies real estate + +482 +00:36:38,590 --> 00:36:44,590 +commodities etc وين احنا بنستثمر فبنحط هدول ال + +483 +00:36:44,590 --> 00:36:47,510 +families هدول families of the of the investments + +484 +00:36:47,510 --> 00:36:50,510 +بنشوف هدول ال families و بنشوف مقرر احنا بنعمل + +485 +00:36:50,510 --> 00:36:53,430 +investment في ال stock ولا نعمل investment في ال + +486 +00:36:53,430 --> 00:37:00,240 +bonds ولا وينOkay let's say we .. we agree to do + +487 +00:37:00,240 --> 00:37:04,260 +investments in stocks so this is the first action + +488 +00:37:04,260 --> 00:37:08,700 +أول شغلة بنسويها أنه احنا بنشوف عندنا الله أنا + +489 +00:37:08,700 --> 00:37:14,600 +بشوف بفهم بال bonds ممكن بفهم بفهمش بال currencies + +490 +00:37:14,600 --> 00:37:16,880 +عندك خبرة بال currencies عندك خبرة بال commodities + +491 +00:37:16,880 --> 00:37:20,400 +بال real estate فالناس اللي مثلا عندك خبرة بال + +492 +00:37:20,400 --> 00:37:24,970 +stocks بروح على ال stocks هذه أول خطوة عملناهاOkay + +493 +00:37:24,970 --> 00:37:31,130 +then so choice among broad asset classes هدول + +494 +00:37:31,130 --> 00:37:33,810 +بيسموهم asset classes لإنه عندنا bonds, + +495 +00:37:34,810 --> 00:37:41,750 +currencies, commodities and etc The second step is + +496 +00:37:41,750 --> 00:37:49,200 +security selectionin each class there is a broad + +497 +00:37:49,200 --> 00:37:52,960 +investment tools يعني خلينا نيجي نحكي احنا حكينا + +498 +00:37:52,960 --> 00:37:56,560 +عن ال stocks بدنا نستثمر بال stocks، مظبوط؟ طيب، + +499 +00:37:56,560 --> 00:38:03,120 +اذا هدول مابلزمونا صح؟ stocks the second question + +500 +00:38:03,120 --> 00:38:11,020 +you ask yourself which stock؟ أي سهمOkay احنا + +501 +00:38:11,020 --> 00:38:13,660 +بنستثمر في ال .. في ال stocks بس أي شركة بنشتري + +502 +00:38:13,660 --> 00:38:17,520 +يعني if you look at the PSE you know what it means + +503 +00:38:17,520 --> 00:38:22,000 +PSE Palestine Stock Exchange if we look at the PSE + +504 +00:38:22,000 --> 00:38:26,460 +سوق المال الفلسطيني we have many companies the + +505 +00:38:26,460 --> 00:38:30,580 +question is which company you want to invest اي + +506 +00:38:30,580 --> 00:38:35,100 +شركة انت بدك تستثمر Paltel, Badeco, AIB, Bob which + +507 +00:38:35,100 --> 00:38:40,330 +company and whyإذا إحنا بدنا نقرر في الخطوة + +508 +00:38:40,330 --> 00:38:44,710 +التانية which is security selection which company + +509 +00:38:44,710 --> 00:38:50,230 +you want to invest in the family of stocks or in + +510 +00:38:50,230 --> 00:38:54,590 +the class of stocks أي واحدة ممكن تقولوا بالتم you + +511 +00:38:54,590 --> 00:39:05,530 +want بالتم you want بوب sorry بوب you want aib you + +512 +00:39:05,530 --> 00:39:10,480 +want badicowhat you want so I recommend you to + +513 +00:39:10,480 --> 00:39:16,820 +take a look at the psa.com and see the stocks + +514 +00:39:16,820 --> 00:39:27,060 +افتحوا ال website و اكتب www.b-s-e.bs then see the + +515 +00:39:27,060 --> 00:39:29,920 +companies listed in the financial markets or + +516 +00:39:29,920 --> 00:39:35,690 +palestinian financial marketsOkay, so we go to + +517 +00:39:35,690 --> 00:39:42,170 +بالتل استثمرنا في بالتل why? because maybe the + +518 +00:39:42,170 --> 00:39:46,010 +بالتل is one of the company fits with my + +519 +00:39:46,010 --> 00:39:49,710 +characteristics لأن الشركة بالتل تناسب ال + +520 +00:39:49,710 --> 00:39:52,330 +characteristics تبعتي and we will discuss what it + +521 +00:39:52,330 --> 00:39:57,200 +means thisإذا خلصنا security selection choice of + +522 +00:39:57,200 --> 00:40:00,600 +which securities to hold within asset classes أي + +523 +00:40:00,600 --> 00:40:06,980 +واحدة بدها تكون في ال asset classes fine then يعني + +524 +00:40:06,980 --> 00:40:10,860 +ال security selection بتشمل عدة خطوات الخطوة + +525 +00:40:10,860 --> 00:40:14,400 +الأولى زي ما أنتوا شايفين استعرضنا الشركات في + +526 +00:40:14,400 --> 00:40:19,560 +السوق المالي شفناهم شفنا بالتل شفنا بديكو شفنا AIB + +527 +00:40:19,560 --> 00:40:28,840 +شفنا الBOB ل AIB okay وعملنا لهم analysis عملنا + +528 +00:40:28,840 --> 00:40:33,740 +لهم إيش تحليل تحليل كتير في financial analysis في + +529 +00:40:33,740 --> 00:40:36,740 +economic analysis في managerial analysis في + +530 +00:40:36,740 --> 00:40:41,520 +analysis كتير في technical analysis يعني عملنا + +531 +00:40:41,520 --> 00:40:46,280 +تحليلات لهذه الشركات هذه التحليلات بتساعدني أعمل + +532 +00:40:46,280 --> 00:40:48,540 +okay إذا بقلت اللي منيحة + +533 +00:40:55,060 --> 00:41:00,280 +بعد ما احنا نعمل التحليلات نعمل risk-return trade + +534 +00:41:00,280 --> 00:41:05,400 +-off risk and return trade-off نفهم what it means + +535 +00:41:05,400 --> 00:41:13,600 +احنا هان اخترنا palatal okay how we select palatal + +536 +00:41:13,600 --> 00:41:20,820 +شوفوا هان، هان عند ال risk و هان عند ال return هذا + +537 +00:41:20,820 --> 00:41:25,840 +ال risk المخاطر وهنا إيش العائدالعلاقة بين العائد + +538 +00:41:25,840 --> 00:41:29,560 +والمخاطر هي علاقة إيجابية ال risk بيزيد العائد + +539 +00:41:29,560 --> 00:41:34,580 +بيزيد okay so when the risk increase the return is + +540 +00:41:34,580 --> 00:41:39,480 +increase okay زي ما أنتوا شايفين there is a + +541 +00:41:39,480 --> 00:41:43,020 +positive relationship between the risk and return + +542 +00:41:43,020 --> 00:41:51,120 +طيب هلأ بنيجي كل ما احنا نطلع لفوق ال risk بيزيد و + +543 +00:41:51,120 --> 00:41:55,030 +ال return بيزيدمثلا اللي بيستثمروا في palatal هم + +544 +00:41:55,030 --> 00:41:59,990 +ناس نحكي neutral ماعندهم كتير risk و ماعندهم كتير + +545 +00:41:59,990 --> 00:42:08,690 +مخاطر palatal is located in this place so + +546 +00:42:08,690 --> 00:42:13,410 +palatal is reflecting a particular risk and a + +547 +00:42:13,410 --> 00:42:17,540 +particular returnfor a conservative people للناس + +548 +00:42:17,540 --> 00:42:20,540 +المحافظين الناس اللي مابدهمش يتحملوا مخاطر كتير و + +549 +00:42:20,540 --> 00:42:23,680 +في نفس اللحظة الناس مابدهمش يكون عندهم عائد مخفض + +550 +00:42:23,680 --> 00:42:30,120 +بقالت بتوزع dividends بتوزع أرباح okay مخاطرها + +551 +00:42:30,120 --> 00:42:35,900 +مخفضة و عائدها متوسط أو مخفض لو أجينا احنا أخدنا + +552 +00:42:35,900 --> 00:42:40,080 +شركة أخرى مثلالأنه احنا مثلا إذا بدك تحكي عن ال + +553 +00:42:40,080 --> 00:42:43,620 +bob okay bank of Palestine I don't know ممكن + +554 +00:42:43,620 --> 00:42:51,540 +according to you maybe bob according to you not + +555 +00:42:51,540 --> 00:42:55,660 +according to me bob maybe is higher risk and + +556 +00:42:55,660 --> 00:42:59,800 +higher return so people they may think this is + +557 +00:42:59,800 --> 00:43:03,980 +holding high risk so they may avoid the bob ممكن + +558 +00:43:03,980 --> 00:43:09,490 +يتجنبوا ال bobOkay زي ما انتوا عائد عليه بتتحملوا + +559 +00:43:09,490 --> 00:43:14,770 +مخاطر أعلى ال BOP stand for Bank of Palestine يعني + +560 +00:43:14,770 --> 00:43:22,530 +Bank فلسطين okay هذا هو trade-off between risk + +561 +00:43:22,530 --> 00:43:28,130 +and return نجح + +562 +00:43:28,130 --> 00:43:31,650 +عند هذا اللقاء + +563 +00:43:31,650 --> 00:43:34,390 +الجاي مطلوب منكم تقرأوا عن efficient markets + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/2sBv6juKWtc_raw.json b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/2sBv6juKWtc_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..5342ff37acd1332c2c6d12f73d1a65c9a146ded2 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/2sBv6juKWtc_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4869, "start": 20.65, "end": 48.69, "text": "الله الرحمن الرحيم المرة الأولى تكون نحكي عن ال relationship between treasury bills and inflation rates اليوم هنحكي العلاقة بين ال risk and 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107.32, "text": "مين بيحمل المخاطر اكتر؟ ال stocks ولا ال bonds؟ bonds طبعا هناخد risk هان و هناخد ال expected return يعني هاي ال risk و هاي ال return اذا ال stocks holding more risk than ال bonds ال stocks بتحمل مخاطر اعلى من ال bonds، مظبوط؟ طيب يعني لو احنا أخدمها ال bonds", "tokens": [2304, 9957, 4724, 1829, 35571, 1211, 9673, 9778, 41193, 2288, 1975, 4117, 2655, 2288, 22807, 2423, 12966, 49429, 2423, 14713, 22807, 14713, 23032, 3555, 3615, 995, 8032, 1863, 47283, 3215, 3148, 8032, 7649, 4032, 8032, 1863, 47283, 3215, 2423, 5176, 2736, 37495, 22653, 8032, 47302, 2423, 3148, 4032, 8032, 47302, 2423, 2736, 1975, 15730, 2423, 12966, 5061, 544, 3148, 813, 2423, 14713, 2423, 12966, 39894, 35571, 1211, 3714, 9778, 41193, 2288, 1975, 3615, 23942, 9154, 2423, 14713, 12399, 3714, 19913, 3555, 2407, 9566, 22807, 23032, 1829, 3555, 37495, 22653, 45164, 1975, 5016, 8315, 5551, 9778, 40448, 11296, 2423, 14713], "avg_logprob": -0.1971874988079071, "compression_ratio": 1.8038277511961722, 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" stocks", "probability": 0.92578125}, {"start": 98.0, "end": 98.52, "word": " بتحمل", "probability": 0.9685872395833334}, {"start": 98.52, "end": 98.92, "word": " مخاطر", "probability": 0.97998046875}, {"start": 98.92, "end": 99.18, "word": " اعلى", "probability": 0.8704427083333334}, {"start": 99.18, "end": 99.32, "word": " من", "probability": 0.99609375}, {"start": 99.32, "end": 99.44, "word": " ال", "probability": 0.97509765625}, {"start": 99.44, "end": 100.1, "word": " bonds،", "probability": 0.7099609375}, {"start": 100.1, "end": 100.84, "word": " مظبوط؟", "probability": 0.8942057291666666}, {"start": 100.84, "end": 102.4, "word": " طيب", "probability": 0.9305013020833334}, {"start": 102.4, "end": 103.0, "word": " يعني", "probability": 0.8251953125}, {"start": 103.0, "end": 103.16, "word": " لو", "probability": 0.93994140625}, {"start": 103.16, "end": 103.36, "word": " احنا", "probability": 0.962890625}, {"start": 103.36, "end": 103.86, "word": " أخدمها", "probability": 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this", "probability": 0.9443359375}, {"start": 130.38, "end": 130.88, "word": " chart", "probability": 0.9091796875}, {"start": 130.88, "end": 131.68, "word": " اذا", "probability": 0.71826171875}, {"start": 131.68, "end": 131.92, "word": " هذا", "probability": 0.91259765625}, {"start": 131.92, "end": 132.04, "word": " ال", "probability": 0.88427734375}, {"start": 132.04, "end": 132.28, "word": " risk", "probability": 0.92578125}, {"start": 132.28, "end": 133.42, "word": " risk", "probability": 0.2880859375}, {"start": 133.42, "end": 133.7, "word": " is", "probability": 0.94921875}, {"start": 133.7, "end": 134.06, "word": " measured", "probability": 0.82421875}, {"start": 134.06, "end": 134.3, "word": " by", "probability": 0.96875}, {"start": 134.3, "end": 134.64, "word": " sigma", "probability": 0.53857421875}, {"start": 134.64, "end": 136.62, "word": " we", "probability": 0.46533203125}, {"start": 136.62, "end": 136.76, "word": " will", "probability": 0.87744140625}, {"start": 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"end": 268.62, "word": " to", "probability": 0.9052734375}, {"start": 268.62, "end": 268.76, "word": " go", "probability": 0.97314453125}, {"start": 268.76, "end": 268.92, "word": " in", "probability": 0.94970703125}, {"start": 268.92, "end": 269.22, "word": " details", "probability": 0.84228515625}, {"start": 269.22, "end": 269.46, "word": " about", "probability": 0.93896484375}, {"start": 269.46, "end": 269.8, "word": " this", "probability": 0.96826171875}], "temperature": 1.0}, {"id": 10, "seek": 29383, "start": 270.62, "end": 293.84, "text": "خلّينا ندخل في التفاصيل خلّينا ت estimate the expected rate of return of stocks or of bonds و بعدين بنعمل estimation لل sigma then we calculate the differences in the risk premium لأنه احنا هتحملنا مخاطر أعلى فال return هيكون أعلى فالخريطة تبعتنا من هان لكمان يومان", "tokens": [9778, 1211, 11703, 9957, 995, 8717, 3215, 9778, 1211, 8978, 16712, 5172, 33546, 26895, 16490, 1211, 11703, 9957, 995, 6055, 12539, 264, 5176, 3314, 295, 2736, 295, 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"probability": 0.99169921875}, {"start": 310.75, "end": 311.21, "word": " variance", "probability": 0.90771484375}, {"start": 311.21, "end": 312.43, "word": " هنحكي", "probability": 0.95673828125}, {"start": 312.43, "end": 312.71, "word": " فيها", "probability": 0.989990234375}, {"start": 312.71, "end": 313.17, "word": " okay", "probability": 0.76025390625}, {"start": 313.17, "end": 314.23, "word": " أخدتوها", "probability": 0.8710123697916666}, {"start": 314.23, "end": 314.43, "word": " بال", "probability": 0.962890625}, {"start": 314.43, "end": 314.55, "word": " ..", "probability": 0.75390625}, {"start": 314.55, "end": 314.71, "word": " بال", "probability": 0.98388671875}, {"start": 314.71, "end": 315.21, "word": " statistics", "probability": 0.9033203125}, {"start": 315.21, "end": 316.31, "word": " okay", "probability": 0.8857421875}, {"start": 316.31, "end": 317.47, "word": " rates", "probability": 0.88623046875}, {"start": 317.47, "end": 317.59, "word": " of", "probability": 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"probability": 0.801513671875}, {"start": 323.7, "end": 324.14, "word": " b1", "probability": 0.545654296875}, {"start": 324.14, "end": 324.54, "word": " minus", "probability": 0.31201171875}, {"start": 324.54, "end": 325.06, "word": " b0", "probability": 0.747314453125}, {"start": 325.06, "end": 326.22, "word": " plus", "probability": 0.9296875}, {"start": 326.22, "end": 327.26, "word": " d1", "probability": 0.830322265625}, {"start": 327.26, "end": 327.58, "word": " على", "probability": 0.74951171875}, {"start": 327.58, "end": 328.02, "word": " b0", "probability": 0.973388671875}, {"start": 328.02, "end": 328.46, "word": " طبعا", "probability": 0.9580078125}, {"start": 328.46, "end": 328.72, "word": " هذا", "probability": 0.8115234375}, {"start": 328.72, "end": 329.02, "word": " ال", "probability": 0.79150390625}, {"start": 329.02, "end": 329.16, "word": " rate", "probability": 0.9833984375}, {"start": 329.16, "end": 329.28, "word": " of", "probability": 0.9677734375}, {"start": 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"probability": 0.36962890625}, {"start": 526.46, "end": 526.96, "word": " return", "probability": 0.8955078125}, {"start": 526.96, "end": 527.46, "word": " ..", "probability": 0.2060546875}, {"start": 527.46, "end": 529.18, "word": " the", "probability": 0.6650390625}, {"start": 529.18, "end": 529.46, "word": " return", "probability": 0.95166015625}, {"start": 529.46, "end": 529.7, "word": " is", "probability": 0.97265625}, {"start": 529.7, "end": 530.16, "word": " divided", "probability": 0.87890625}, {"start": 530.16, "end": 531.12, "word": " or", "probability": 0.85400390625}, {"start": 531.12, "end": 531.34, "word": " is", "probability": 0.7939453125}, {"start": 531.34, "end": 531.9, "word": " break", "probability": 0.6416015625}, {"start": 531.9, "end": 532.14, "word": " down", "probability": 0.82080078125}, {"start": 532.14, "end": 532.46, "word": " into", "probability": 0.78125}, {"start": 532.46, "end": 532.88, "word": " two", "probability": 0.9560546875}, {"start": 532.88, 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"probability": 0.93603515625}, {"start": 548.82, "end": 549.26, "word": " yields", "probability": 0.95556640625}, {"start": 549.26, "end": 550.4, "word": " يعني", "probability": 0.9306640625}, {"start": 550.4, "end": 551.08, "word": " بيعطيني", "probability": 0.95419921875}, {"start": 551.08, "end": 551.72, "word": " عائدين", "probability": 0.984619140625}, {"start": 551.72, "end": 552.16, "word": " باختلفة", "probability": 0.84150390625}, {"start": 552.16, "end": 552.26, "word": " عن", "probability": 0.99169921875}, {"start": 552.26, "end": 552.56, "word": " بعض", "probability": 0.9970703125}, {"start": 552.56, "end": 553.88, "word": " العائد", "probability": 0.9705403645833334}, {"start": 553.88, "end": 554.12, "word": " الأول", "probability": 0.965087890625}, {"start": 554.12, "end": 554.5, "word": " بيسموه", "probability": 0.88125}, {"start": 554.5, "end": 554.8, "word": " capital", "probability": 0.9208984375}, {"start": 554.8, "end": 555.36, "word": " gains", "probability": 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{"start": 564.02, "end": 564.2, "word": " ناس", "probability": 0.966796875}, {"start": 564.2, "end": 564.6, "word": " بيسموه", "probability": 0.98193359375}, {"start": 564.6, "end": 564.96, "word": " current", "probability": 0.86865234375}, {"start": 564.96, "end": 565.42, "word": " yield", "probability": 0.84423828125}, {"start": 565.42, "end": 566.7, "word": " طيب", "probability": 0.8875325520833334}, {"start": 566.7, "end": 567.28, "word": " نطلع", "probability": 0.7982177734375}, {"start": 567.28, "end": 567.42, "word": " على", "probability": 0.334228515625}, {"start": 567.42, "end": 568.24, "word": " المعادلة", "probability": 0.91064453125}, {"start": 568.24, "end": 568.68, "word": " تبعتنا", "probability": 0.8221435546875}], "temperature": 1.0}, {"id": 21, "seek": 59504, "start": 569.76, "end": 595.04, "text": "حلتوه الكلام هذا حلتوه اه لحظة حلتوه الكلام هذا okay نرجع للمعادرة is b1 minus b0 نفس المعادرة هذه بس just we break it up into two equations plus d1 divided by b0", 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"end": 648.04, "text": "Capital Gain وهذا الجزء يعرف بـ Dividends Yields لدينا اثنين جزءين مختلفة، الـ Capital Gains وDividends Yields الـ Capital Gains تحدث فقط عندما نبيع الأسات", "tokens": [34, 569, 1686, 460, 491, 37037, 15730, 25724, 11622, 38207, 37495, 28480, 4724, 39184, 413, 1843, 2581, 398, 1789, 82, 5296, 16254, 8315, 1975, 12984, 1863, 9957, 10874, 11622, 38207, 9957, 3714, 46456, 46538, 3660, 12399, 2423, 39184, 21502, 460, 2315, 4032, 35, 1843, 2581, 398, 1789, 82, 2423, 39184, 21502, 460, 2315, 6055, 24401, 12984, 6156, 47432, 43242, 15042, 8717, 21292, 3615, 16247, 3794, 9307], "avg_logprob": -0.696828368884414, "compression_ratio": 1.4350649350649352, "no_speech_prob": 0.0, "words": [{"start": 624.24, "end": 624.68, "word": "Capital", "probability": 0.5842183430989584}, {"start": 624.68, "end": 624.96, "word": " Gain", "probability": 0.564697265625}, {"start": 624.96, "end": 626.34, "word": " وهذا", "probability": 0.341796875}, {"start": 626.34, "end": 626.82, "word": 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"word": " وDividends", "probability": 0.77813720703125}, {"start": 641.38, "end": 643.68, "word": " Yields", "probability": 0.9381510416666666}, {"start": 643.68, "end": 643.74, "word": " الـ", "probability": 0.41986083984375}, {"start": 643.74, "end": 644.04, "word": " Capital", "probability": 0.89404296875}, {"start": 644.04, "end": 644.6, "word": " Gains", "probability": 0.927978515625}, {"start": 644.6, "end": 645.54, "word": " تحدث", "probability": 0.5077921549479166}, {"start": 645.54, "end": 645.92, "word": " فقط", "probability": 0.73681640625}, {"start": 645.92, "end": 646.24, "word": " عندما", "probability": 0.53729248046875}, {"start": 646.24, "end": 647.52, "word": " نبيع", "probability": 0.7014973958333334}, {"start": 647.52, "end": 648.04, "word": " الأسات", "probability": 0.2489013671875}], "temperature": 1.0}, {"id": 24, "seek": 67795, "start": 648.81, "end": 677.95, "text": "يعني ال capital gains بس بتحدث عندما بنبيع ال assets بنعطيكوا مثال من الحياة العملية تبعتنا لو احنا اشترينا مثلا بيت real estate اشترينا البيت هذا ب 100 أرض دولار okay انتبهوا معايا و ركزوا okay اشترينا البيت هذا by one hundred thousand dollar the real .. the house", "tokens": [40228, 22653, 2423, 4238, 16823, 4724, 3794, 39894, 24401, 12984, 43242, 15042, 44945, 21292, 3615, 2423, 9769, 44945, 3615, 9566, 1829, 4117, 14407, 50113, 6027, 9154, 21542, 25528, 3660, 18863, 42213, 10632, 6055, 3555, 34268, 8315, 45164, 1975, 5016, 8315, 1975, 8592, 2655, 16572, 8315, 50113, 15040, 4724, 36081, 957, 9749, 1975, 8592, 2655, 16572, 8315, 2423, 21292, 2655, 23758, 4724, 2319, 5551, 43042, 11778, 12610, 9640, 1392, 16472, 2655, 3555, 3224, 14407, 20449, 995, 25528, 4032, 12602, 4117, 11622, 14407, 1392, 1975, 8592, 2655, 16572, 8315, 2423, 21292, 2655, 23758, 538, 472, 3262, 4714, 7241, 264, 957, 4386, 264, 1782], "avg_logprob": -0.18749999576339535, "compression_ratio": 1.6736401673640167, "no_speech_prob": 0.0, "words": [{"start": 648.81, "end": 649.09, "word": "يعني", "probability": 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1.0}, {"id": 25, "seek": 70539, "start": 678.63, "end": 705.39, "text": "or the building we bought the building at one hundred thousand dollars هان ال building طب if I ask you calculate the capital gains and the current yield or dividend yield the same current yield يعني current yield it means العائد الجارى لو أنا سألكم حسبولي قداش العائد الجارى", "tokens": [284, 264, 2390, 321, 4243, 264, 2390, 412, 472, 3262, 4714, 3808, 8032, 7649, 2423, 2390, 23032, 3555, 498, 286, 1029, 291, 8873, 264, 4238, 16823, 293, 264, 2190, 11257, 420, 29796, 11257, 264, 912, 2190, 11257, 37495, 22653, 2190, 11257, 309, 1355, 18863, 16373, 3215, 25724, 9640, 7578, 45164, 41850, 8608, 10721, 23275, 2304, 11331, 35457, 12610, 1829, 12174, 3215, 33599, 18863, 16373, 3215, 25724, 9640, 7578], "avg_logprob": -0.26924819186113885, "compression_ratio": 1.5817307692307692, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 678.63, "end": 678.87, "word": "or", "probability": 0.250244140625}, {"start": 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"word": " ال", "probability": 0.73828125}, {"start": 686.01, "end": 686.43, "word": " building", "probability": 0.96435546875}, {"start": 686.43, "end": 690.19, "word": " طب", "probability": 0.806396484375}, {"start": 690.19, "end": 690.57, "word": " if", "probability": 0.701171875}, {"start": 690.57, "end": 690.73, "word": " I", "probability": 0.6572265625}, {"start": 690.73, "end": 691.07, "word": " ask", "probability": 0.91064453125}, {"start": 691.07, "end": 691.27, "word": " you", "probability": 0.974609375}, {"start": 691.27, "end": 691.97, "word": " calculate", "probability": 0.8623046875}, {"start": 691.97, "end": 692.21, "word": " the", "probability": 0.93310546875}, {"start": 692.21, "end": 692.45, "word": " capital", "probability": 0.93212890625}, {"start": 692.45, "end": 692.91, "word": " gains", "probability": 0.79541015625}, {"start": 692.91, "end": 693.19, "word": " and", "probability": 0.96484375}, {"start": 693.19, "end": 693.49, "word": " the", "probability": 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no additional information مافيش عندي معلومات ان انا how to calculate this if I add up a new information اذا انا اضفتلكم معلومات جديدة قلتلكم the owner of this building decided to rent or to let كلمة let ايش معناه let let معناها انه يؤجر to let the house", "tokens": [15456, 307, 572, 4497, 1589, 19446, 41185, 8592, 18871, 16254, 20449, 1211, 20498, 9307, 16472, 1975, 8315, 577, 281, 8873, 341, 498, 286, 909, 493, 257, 777, 1589, 1975, 15730, 1975, 8315, 1975, 11242, 5172, 2655, 23275, 2304, 20449, 1211, 20498, 9307, 10874, 16254, 41891, 12174, 1211, 2655, 23275, 2304, 264, 7289, 295, 341, 2390, 3047, 281, 6214, 420, 281, 718, 9122, 19528, 3660, 718, 1975, 1829, 8592, 20449, 8315, 3224, 718, 718, 20449, 8315, 11296, 16472, 3224, 7251, 33604, 7435, 2288, 281, 718, 264, 1782], "avg_logprob": -0.14242097495616168, "compression_ratio": 1.5694444444444444, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 706.5, "end": 706.74, "word": "there", "probability": 0.48681640625}, {"start": 706.74, "end": 706.86, "word": " is", "probability": 0.87939453125}, {"start": 706.86, "end": 707.0, "word": " no", "probability": 0.96044921875}, {"start": 707.0, "end": 707.42, "word": " additional", "probability": 0.912109375}, {"start": 707.42, "end": 708.12, "word": " information", "probability": 0.89892578125}, {"start": 708.12, "end": 709.16, "word": " مافيش", "probability": 0.8673502604166666}, {"start": 709.16, "end": 709.36, "word": " عندي", "probability": 0.658447265625}, {"start": 709.36, "end": 709.86, "word": " معلومات", "probability": 0.9842529296875}, {"start": 709.86, "end": 711.16, "word": " ان", "probability": 0.603515625}, {"start": 711.16, "end": 711.38, "word": " انا", "probability": 0.856689453125}, {"start": 711.38, "end": 711.54, "word": " how", "probability": 0.9560546875}, {"start": 711.54, "end": 711.68, "word": " to", "probability": 0.9873046875}, {"start": 711.68, "end": 712.0, "word": " calculate", "probability": 0.97314453125}, {"start": 712.0, 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"probability": 0.9921875}, {"start": 717.06, "end": 717.74, "word": " قلتلكم", "probability": 0.844140625}, {"start": 717.74, "end": 718.52, "word": " the", "probability": 0.8193359375}, {"start": 718.52, "end": 718.84, "word": " owner", "probability": 0.87548828125}, {"start": 718.84, "end": 719.0, "word": " of", "probability": 0.98486328125}, {"start": 719.0, "end": 719.16, "word": " this", "probability": 0.953125}, {"start": 719.16, "end": 719.48, "word": " building", "probability": 0.89990234375}, {"start": 719.48, "end": 719.98, "word": " decided", "probability": 0.5654296875}, {"start": 719.98, "end": 720.28, "word": " to", "probability": 0.984375}, {"start": 720.28, "end": 720.68, "word": " rent", "probability": 0.87939453125}, {"start": 720.68, "end": 721.46, "word": " or", "probability": 0.82421875}, {"start": 721.46, "end": 721.66, "word": " to", "probability": 0.87939453125}, {"start": 721.66, "end": 721.9, "word": " let", "probability": 0.97412109375}, {"start": 721.9, 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"probability": 0.8828125}], "temperature": 1.0}, {"id": 27, "seek": 75633, "start": 729.71, "end": 756.33, "text": "let the house يعني rent to let the house يعني يؤجر ال house to let the house for instance by 6000 a year يعني بده يؤجر البيت ب 6000 دولار بالسنة my question is now there is a capital gain here؟ فيه capital gains؟ إيش الموجود يعني ال capital gains ولا current yield current yield", "tokens": [2631, 264, 1782, 37495, 22653, 6214, 281, 718, 264, 1782, 37495, 22653, 7251, 33604, 7435, 2288, 2423, 1782, 281, 718, 264, 1782, 337, 5197, 538, 41789, 257, 1064, 37495, 22653, 47525, 3224, 7251, 33604, 7435, 2288, 2423, 21292, 2655, 4724, 41789, 11778, 12610, 9640, 20666, 3794, 1863, 3660, 452, 1168, 307, 586, 456, 307, 257, 4238, 6052, 510, 22807, 8978, 3224, 4238, 16823, 22807, 11933, 1829, 8592, 9673, 29245, 23328, 37495, 22653, 2423, 4238, 16823, 49429, 2190, 11257, 2190, 11257], "avg_logprob": -0.2173996854711462, "compression_ratio": 1.6945812807881773, "no_speech_prob": 0.0, 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"end": 748.85, "word": " a", "probability": 0.951171875}, {"start": 748.85, "end": 749.11, "word": " capital", "probability": 0.95166015625}, {"start": 749.11, "end": 749.35, "word": " gain", "probability": 0.90576171875}, {"start": 749.35, "end": 750.31, "word": " here؟", "probability": 0.530029296875}, {"start": 750.31, "end": 750.51, "word": " فيه", "probability": 0.722412109375}, {"start": 750.51, "end": 750.77, "word": " capital", "probability": 0.92822265625}, {"start": 750.77, "end": 751.79, "word": " gains؟", "probability": 0.83544921875}, {"start": 751.79, "end": 752.01, "word": " إيش", "probability": 0.7411295572916666}, {"start": 752.01, "end": 752.35, "word": " الموجود", "probability": 0.9231770833333334}, {"start": 752.35, "end": 752.45, "word": " يعني", "probability": 0.6431884765625}, {"start": 752.45, "end": 752.57, "word": " ال", "probability": 0.1475830078125}, {"start": 752.57, "end": 752.81, "word": " capital", "probability": 0.94873046875}, {"start": 752.81, "end": 753.13, "word": " gains", "probability": 0.7978515625}, {"start": 753.13, "end": 753.35, "word": " ولا", "probability": 0.630859375}, {"start": 753.35, "end": 753.75, "word": " current", "probability": 0.7529296875}, {"start": 753.75, "end": 754.13, "word": " yield", "probability": 0.85498046875}, {"start": 754.13, "end": 755.35, "word": " current", "probability": 0.243896484375}, {"start": 755.35, "end": 756.33, "word": " yield", "probability": 0.9189453125}], "temperature": 1.0}, {"id": 28, "seek": 78004, "start": 757.26, "end": 780.04, "text": "there is no capital gains لأن ال capital gains only occurs when we sell the business يعني ال capital gains بحدث لما بس احنا بيها as long as we are holding the business it means we only receive a current yield what is the current yield طب قداش ال current yield خلينا نطبق ال equation", "tokens": [15456, 307, 572, 4238, 16823, 5296, 33456, 2423, 4238, 16823, 787, 11843, 562, 321, 3607, 264, 1606, 37495, 22653, 2423, 4238, 16823, 4724, 24401, 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" عائد", "probability": 0.8644205729166666}, {"start": 1171.99, "end": 1172.31, "word": " السنة", "probability": 0.8885091145833334}, {"start": 1172.31, "end": 1172.53, "word": " الجاية", "probability": 0.7177734375}, {"start": 1172.53, "end": 1173.29, "word": " nobody", "probability": 0.91015625}, {"start": 1173.29, "end": 1173.71, "word": " knows", "probability": 0.87060546875}, {"start": 1173.71, "end": 1174.59, "word": " exactly", "probability": 0.88037109375}, {"start": 1174.59, "end": 1175.11, "word": " ماحدش", "probability": 0.8151041666666666}, {"start": 1175.11, "end": 1175.35, "word": " يعرف", "probability": 0.686767578125}, {"start": 1175.35, "end": 1175.87, "word": " بالظبط", "probability": 0.9886474609375}, {"start": 1175.87, "end": 1176.39, "word": " but", "probability": 0.54931640625}, {"start": 1176.39, "end": 1176.71, "word": " we", "probability": 0.95654296875}, {"start": 1176.71, "end": 1177.11, "word": " try", "probability": 0.94677734375}, {"start": 1177.11, "end": 1177.27, "word": " to", "probability": 0.97900390625}, {"start": 1177.27, "end": 1177.73, "word": " predict", "probability": 0.9072265625}, {"start": 1177.73, "end": 1178.59, "word": " نحاول", "probability": 0.9193115234375}, {"start": 1178.59, "end": 1179.07, "word": " نتنبأ", "probability": 0.965234375}], "temperature": 1.0}, {"id": 44, "seek": 119958, "start": 1180.1, "end": 1199.58, "text": "we try to forecast by using the probability نستخدم الاحتمالات okay so let's see how it works طبعا هذا كله شرحنا ال beginning price و ال ending price okay and I give you the samples okay طيب هلأ نيجي نحكي على الاحتمال", "tokens": [826, 853, 281, 14330, 538, 1228, 264, 8482, 8717, 14851, 9778, 40448, 42963, 33753, 2304, 6027, 9307, 1392, 370, 718, 311, 536, 577, 309, 1985, 23032, 3555, 3615, 995, 23758, 28242, 3224, 13412, 2288, 5016, 8315, 2423, 2863, 3218, 4032, 2423, 8121, 3218, 1392, 293, 286, 976, 291, 264, 10938, 1392, 23032, 1829, 3555, 8032, 1211, 10721, 8717, 1829, 7435, 1829, 8717, 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1194.2, "end": 1195.08, "word": " samples", "probability": 0.55419921875}, {"start": 1195.08, "end": 1196.1, "word": " okay", "probability": 0.86328125}, {"start": 1196.1, "end": 1197.56, "word": " طيب", "probability": 0.8883463541666666}, {"start": 1197.56, "end": 1198.22, "word": " هلأ", "probability": 0.6328938802083334}, {"start": 1198.22, "end": 1198.4, "word": " نيجي", "probability": 0.965087890625}, {"start": 1198.4, "end": 1198.74, "word": " نحكي", "probability": 0.9842529296875}, {"start": 1198.74, "end": 1198.9, "word": " على", "probability": 0.93017578125}, {"start": 1198.9, "end": 1199.58, "word": " الاحتمال", "probability": 0.94287109375}], "temperature": 1.0}, {"id": 45, "seek": 121965, "start": 1202.07, "end": 1219.65, "text": "the expectation of r we use the expectation of r the expectation of the of the rates of the return for the future إذا ال expectation نستخدمها لفيوتر the question is what is the expected return for the future اتطلعوا على المثال اللي أعطاكوايا", 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0.97021484375}, {"start": 1264.08, "end": 1264.34, "word": " need", "probability": 0.95751953125}, {"start": 1264.34, "end": 1264.62, "word": " to", "probability": 0.97509765625}, {"start": 1264.62, "end": 1265.72, "word": " memorize", "probability": 0.73486328125}, {"start": 1265.72, "end": 1266.72, "word": " لا", "probability": 0.2479248046875}, {"start": 1266.72, "end": 1267.08, "word": " تحاولوش", "probability": 0.8584798177083334}, {"start": 1267.08, "end": 1267.24, "word": " انك", "probability": 0.45361328125}, {"start": 1267.24, "end": 1267.58, "word": " تحفظوا", "probability": 0.93427734375}, {"start": 1267.58, "end": 1267.86, "word": " كتير", "probability": 0.9822591145833334}, {"start": 1267.86, "end": 1269.0, "word": " just", "probability": 0.8896484375}, {"start": 1269.0, "end": 1269.72, "word": " consider", "probability": 0.9306640625}, {"start": 1269.72, "end": 1269.94, "word": " this", "probability": 0.96728515625}, {"start": 1269.94, "end": 1270.3, "word": " case", "probability": 0.9326171875}, {"start": 1270.3, "end": 1271.58, "word": " خدوا", "probability": 0.9697265625}, {"start": 1271.58, "end": 1272.02, "word": " هال", "probability": 0.71044921875}, {"start": 1272.02, "end": 1272.74, "word": " مثال", "probability": 0.656005859375}, {"start": 1272.74, "end": 1273.28, "word": " البسيط", "probability": 0.9835205078125}], "temperature": 1.0}, {"id": 48, "seek": 130083, "start": 1274.89, "end": 1300.83, "text": "لو احنا if we think to invest in a particular stock for the next year طبعا لما نحكي next year نحكي for the future and you given this information و أعطيناكوا هالمعلومات هذه the expected R and the probability the probability of R to occur يعني احتمال R انه تحدث", "tokens": [1211, 2407, 1975, 5016, 8315, 498, 321, 519, 281, 1963, 294, 257, 1729, 4127, 337, 264, 958, 1064, 23032, 3555, 3615, 995, 5296, 15042, 8717, 5016, 4117, 1829, 958, 1064, 8717, 5016, 4117, 1829, 337, 264, 2027, 293, 291, 2212, 341, 1589, 4032, 5551, 3615, 9566, 1829, 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معاهم ال calculators يتأكدوا من ال ..", "tokens": [13, 15, 7271, 23032, 3555, 28811, 1975, 7435, 2304, 3615, 16095, 20449, 45030, 11242, 1958, 13, 16231, 5211, 37495, 22653, 39894, 9566, 1211, 3615, 25724, 2407, 6027, 13672, 1829, 31439, 1614, 13, 5211, 4, 11933, 15730, 2423, 5176, 497, 307, 2681, 281, 1614, 13, 5211, 4, 23032, 3555, 3615, 995, 29739, 8315, 2655, 13672, 1829, 20449, 995, 16095, 2423, 4322, 3391, 7251, 2655, 10721, 4117, 3215, 14407, 9154, 2423, 4386], "avg_logprob": -0.27926935276515047, "compression_ratio": 1.3257142857142856, "no_speech_prob": 1.3113021850585938e-06, "words": [{"start": 1421.4599999999998, "end": 1422.36, "word": ".014", "probability": 0.6200358072916666}, {"start": 1422.36, "end": 1423.26, "word": " طب", "probability": 0.5517578125}, {"start": 1423.26, "end": 1424.22, "word": " summation", "probability": 0.396240234375}, {"start": 1424.22, "end": 1425.74, "word": " اجمعهم", "probability": 0.8720703125}, {"start": 1425.74, "end": 1425.9, "word": " 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صح؟ بس هلجيت إيش رأيك؟ تعالي أعطيني ال possible وارجيني أشوف عشان نعرف what it means uncertainty", "tokens": [9566, 1829, 3555, 1975, 5016, 8315, 8032, 15040, 4724, 5853, 1392, 5853, 3714, 9957, 4724, 1829, 28543, 2288, 7251, 25957, 1211, 32239, 3224, 22807, 39896, 3714, 29245, 23328, 3660, 39896, 4117, 1392, 11933, 1829, 8592, 12602, 10721, 1829, 4117, 22807, 39894, 10721, 4117, 3215, 37495, 22653, 22807, 4724, 3794, 5296, 15042, 6156, 9307, 19446, 23032, 1211, 34268, 25961, 2655, 1975, 33753, 2304, 6027, 6055, 10721, 4117, 3215, 6225, 6027, 1829, 20328, 5016, 22807, 4724, 3794, 8032, 1211, 7435, 36081, 11933, 1829, 8592, 12602, 10721, 1829, 4117, 22807, 37279, 6027, 1829, 5551, 3615, 9566, 9957, 1829, 2423, 1944, 4032, 9640, 7435, 9957, 1829, 5551, 8592, 38688, 6225, 8592, 7649, 8717, 3615, 28480, 437, 309, 1355, 15697], "avg_logprob": -0.2050107698245295, "compression_ratio": 1.5947136563876652, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1625.47, "end": 1625.79, 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"language_probability": 1.0, "duration": 2185.74075, "duration_after_vad": 2048.292499999995} \ No newline at end of file diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/4qmkBLfi5sY.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/4qmkBLfi5sY.srt new file mode 100644 index 0000000000000000000000000000000000000000..1990077d3f00296dc7d66f4b1ad8681f4fb6f37c --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/4qmkBLfi5sY.srt @@ -0,0 +1,2035 @@ +1 +00:00:21,340 --> 00:00:25,640 +اليوم احنا هنحكي بـ chapter three which... which + +2 +00:00:25,640 --> 00:00:31,620 +about how securities are traded okay خلينا ناخد بس + +3 +00:00:31,620 --> 00:00:36,420 +ملخص لـ chapter one و chapter two عشان احنا نمشي بـ + +4 +00:00:36,420 --> 00:00:41,660 +chapter three بـ chapter one we talk about the... + +5 +00:00:41,660 --> 00:00:43,960 +the main differences between financial assets and + +6 +00:00:43,960 --> 00:00:49,180 +real assets والقصة الثالثة تحتوي على ثلاث نقاط + +7 +00:00:49,180 --> 00:00:52,160 +الرئيسية والأولى هي الفرق الرئيسي بين الواحدة + +8 +00:00:52,160 --> 00:00:55,240 +المالية والواحدة الحقيقية والنقطة الثانية هي + +9 +00:00:55,240 --> 00:01:00,240 +التعامل بين الواحدة المالية والواحدة الاقتصادية أو + +10 +00:01:00,240 --> 00:01:04,280 +الواحدة المالية الاقتصادية والنقطة الثالثة مرتبطة + +11 +00:01:04,280 --> 00:01:10,550 +مع كيف the investors process their investments or + +12 +00:01:10,550 --> 00:01:13,390 +the investment process So these are the three main + +13 +00:01:13,390 --> 00:01:17,270 +points we talk about in chapter one In chapter two + +14 +00:01:17,270 --> 00:01:21,250 +it is mainly focused on the main difference + +15 +00:01:21,250 --> 00:01:24,330 +between the money market instruments and the + +16 +00:01:24,330 --> 00:01:26,810 +capital market instruments So you should know + +17 +00:01:26,810 --> 00:01:30,030 +about the main characteristics of the money market + +18 +00:01:30,030 --> 00:01:33,070 +instruments or tools and the capital market + +19 +00:01:33,070 --> 00:01:36,340 +instruments and tools today I'm going to talk about + +20 +00:01:36,340 --> 00:01:40,520 +how these securities which is discussed in chapter + +21 +00:01:40,520 --> 00:01:42,920 +one and chapter two how these securities are + +22 +00:01:42,920 --> 00:01:45,440 +traded in the financial markets يعني كيف هاي الـ + +23 +00:01:45,440 --> 00:01:51,500 +tools هاي الـ instruments كيف احنا تم تدولها في + +24 +00:01:51,500 --> 00:01:55,520 +الأسواق المالية okay which is more practical + +25 +00:01:55,520 --> 00:02:01,130 +chapter هذا chapter practical it includes some + +26 +00:02:01,130 --> 00:02:04,150 +regulations and some instructions on how to trade + +27 +00:02:04,150 --> 00:02:06,410 +in the financial markets يعني هي في بعض الـ + +28 +00:02:06,410 --> 00:02:11,970 +instructions بعض التعليمات والتوجيهات اللي كيف أنه + +29 +00:02:11,970 --> 00:02:16,170 +احنا نستخدمه في الأسواق المالية it mainly depends + +30 +00:02:16,170 --> 00:02:19,130 +on the... the... the regulations and instructions + +31 +00:02:19,130 --> 00:02:21,990 +in the United States هي بتعتمد على الـ regulations + +32 +00:02:21,990 --> 00:02:25,010 +الموجودة بالـ United States however most of these + +33 +00:02:25,010 --> 00:02:27,590 +regulations are applied in the Palestine Stock + +34 +00:02:27,590 --> 00:02:30,970 +Exchange كل أغلب الـ regulations هذه اللي احنا + +35 +00:02:30,970 --> 00:02:33,670 +هبنحكي فيها هي مطبقة في بورصة فلسطين الأوراق المالية + +36 +00:02:33,670 --> 00:02:37,010 +so we don't have... we... we don't have major + +37 +00:02:37,010 --> 00:02:40,150 +differences between the regulations applied in the + +38 +00:02:40,150 --> 00:02:42,830 +United States and the regulations applied in the + +39 +00:02:42,830 --> 00:02:46,320 +... in the... in the Palestine Stock Exchange So + +40 +00:02:46,320 --> 00:02:49,540 +don't get confused about these regulations So + +41 +00:02:49,540 --> 00:02:53,300 +these regulations mainly important for the + +42 +00:02:53,300 --> 00:02:56,120 +investors because they should consider these + +43 +00:02:56,120 --> 00:02:58,660 +regulations before taking any action in the + +44 +00:02:58,660 --> 00:03:02,860 +position يعني هم المستثمرين لازم ياخدوا بالهم من + +45 +00:03:02,860 --> 00:03:06,860 +هذه الـ regulations قبل ما هم يروحوا يفكروا + +46 +00:03:06,860 --> 00:03:09,720 +بالاستثمارات So our subject today is how + +47 +00:03:09,720 --> 00:03:13,160 +securities are traded So I will give you + +48 +00:03:15,880 --> 00:03:19,400 +the main difference between the primary market and + +49 +00:03:19,400 --> 00:03:23,260 +the secondary market which is the first important + +50 +00:03:23,260 --> 00:03:24,660 +point in this chapter + +51 +00:03:31,170 --> 00:03:35,890 +the first thing how firms issue securities كيف + +52 +00:03:35,890 --> 00:03:43,350 +الشركات بتصدر الأوراق المالية أي سوق مالي في + +53 +00:03:43,350 --> 00:03:48,710 +العالم أو أي ورقة مالية لازم تكون فيها two steps + +54 +00:03:48,710 --> 00:03:51,370 +to be in the financial markets لازم يكون في two + +55 +00:03:51,370 --> 00:03:54,390 +steps or two stages two stages to be in the + +56 +00:03:54,390 --> 00:03:58,430 +financial markets لازم تمر في مرحلتين I'm talking + +57 +00:03:58,430 --> 00:04:01,690 +about the public limited companies I'm not talking + +58 +00:04:01,690 --> 00:04:04,550 +about the private limited company أنا بحكي عن + +59 +00:04:04,550 --> 00:04:06,930 +الشركات المساهمة العامة I'm not talking about the + +60 +00:04:06,930 --> 00:04:09,330 +private limited company ومابحكيش عن الشركات + +61 +00:04:09,330 --> 00:04:12,010 +المساهمة المحدودة okay I think this is in the + +62 +00:04:12,010 --> 00:04:15,450 +business research or in the business studies you + +63 +00:04:15,450 --> 00:04:18,170 +have a good knowledge on the main differences + +64 +00:04:18,170 --> 00:04:21,950 +between the corporations so I don't want to go + +65 +00:04:21,950 --> 00:04:25,390 +back to the business studies so in your free time + +66 +00:04:25,390 --> 00:04:28,210 +you can go back and read about the main + +67 +00:04:28,210 --> 00:04:31,630 +differences of these corporations يعني هذا الموضوع + +68 +00:04:31,630 --> 00:04:35,110 +أنه احنا هنحكي عن شركات مساهمة عامة مش هنحكي عن + +69 +00:04:35,110 --> 00:04:38,010 +شركات مساهمة محدودة شركات مساهمة محدودة و other + +70 +00:04:38,010 --> 00:04:42,670 +types of corporations و الأنواع الأخرى من الشركات + +71 +00:04:42,670 --> 00:04:46,010 +مثل الـ solid trader and others هي أصلا أنت درستها + +72 +00:04:46,010 --> 00:04:49,310 +أنت درستوها في دراسات تجارية ففي الوقت الضائع في + +73 +00:04:49,310 --> 00:04:54,220 +الوقت ال... نحكي الـ free time تبعكم ممكن ترجعوا + +74 +00:04:54,220 --> 00:04:57,940 +لدراسات تجارية and you are you seeking the + +75 +00:04:57,940 --> 00:05:03,240 +knowledge from there okay so I'm + +76 +00:05:03,240 --> 00:05:06,680 +talking about the two stages the first stage any + +77 +00:05:06,680 --> 00:05:11,160 +security must be in the primary market this is the + +78 +00:05:11,160 --> 00:05:13,940 +first thing any security it doesn't matter if this + +79 +00:05:13,940 --> 00:05:16,480 +security is issued by the government by + +80 +00:05:16,480 --> 00:05:21,060 +corporation by any other institution it must be go + +81 +00:05:21,060 --> 00:05:24,700 +through the primary markets then after the primary + +82 +00:05:24,700 --> 00:05:29,920 +market it go or it might go to the secondary + +83 +00:05:29,920 --> 00:05:33,740 +markets why I say it might go because it is not + +84 +00:05:33,740 --> 00:05:37,400 +necessary that all of the securities will go to + +85 +00:05:37,400 --> 00:05:42,480 +the secondary markets unless unless they meet the + +86 +00:05:42,480 --> 00:05:44,700 +regulations and the instructions of the financial + +87 +00:05:44,700 --> 00:05:49,510 +markets يعني فقط بروح على الـ secondary market السوق + +88 +00:05:49,510 --> 00:05:55,470 +الثانوي لما يطبقوا كل المعايير اللي مطلوبة من اللي + +89 +00:05:55,470 --> 00:06:00,630 +هي ال... ال... الـ ESC ESC أنا هنشرح في الكلام هذا + +90 +00:06:00,630 --> 00:06:03,790 +في التفاصيل so just to summarize any financial... + +91 +00:06:03,790 --> 00:06:06,950 +any security should go through the primary markets + +92 +00:06:06,950 --> 00:06:11,550 +okay then after that to the secondary markets + +93 +00:06:15,570 --> 00:06:18,570 +the secondary market is the normal market that you + +94 +00:06:18,570 --> 00:06:22,290 +are talking about هو الشكل العادي اللي هو ال... + +95 +00:06:22,290 --> 00:06:24,870 +اللي هو السوق العادي اللي احنا بنعرفه دائما في + +96 +00:06:24,870 --> 00:06:28,450 +الأخبار اللي هو نحكي عن Dow Jones، نحكي عن NASDAQ، + +97 +00:06:28,450 --> 00:06:30,290 +نحكي عن New York Stock Exchange، نحكي عن سوق + +98 +00:06:30,290 --> 00:06:33,150 +فلسطين الأوراق المالية، نحكي عن سوق القاهرة، نحكي + +99 +00:06:33,150 --> 00:06:36,410 +عن سوق خمان، هدول بيسموهم secondary markets The + +100 +00:06:36,410 --> 00:06:39,230 +primary market is running by the investment bank + +101 +00:06:39,230 --> 00:06:44,610 +الـ investment bank is in charge to market the + +102 +00:06:44,610 --> 00:06:49,030 +securities in the primary markets يعني البنك + +103 +00:06:49,030 --> 00:06:54,090 +الاستثمار هو المسئول على الأسواق المالية الأولية + +104 +00:06:54,090 --> 00:07:02,290 +لأن من خلاله the securities are marketed to the + +105 +00:07:02,290 --> 00:07:07,090 +investors لال investors يعني إذا كان عندنا أي شركة + +106 +00:07:07,090 --> 00:07:11,300 +بدأت تصدر شركة ولا حكومة بدأت تصدر أي security Any + +107 +00:07:11,300 --> 00:07:15,700 +security it must go to the... to the investment + +108 +00:07:15,700 --> 00:07:20,080 +bank IB IB is stand for the investment bank and + +109 +00:07:20,080 --> 00:07:22,580 +then this is the... the investors then the + +110 +00:07:22,580 --> 00:07:31,820 +investors buying the securities okay اتفضل اتفضل + +111 +00:07:31,820 --> 00:07:39,950 +اتفضل اتفضل بس بناء على طرح الـ combo شركة okay so + +112 +00:07:39,950 --> 00:07:44,470 +primary markets I'm talking about... سوري أنا حكيت + +113 +00:07:44,470 --> 00:07:47,650 +عن الـ primary market اه okay الـ primary market + +114 +00:07:47,650 --> 00:07:51,370 +فهمش ايش و نية الـ securities through underwriting + +115 +00:07:51,370 --> 00:07:58,250 +to public يعني أي إصدار مالي أي إصدار أوراق مالية + +116 +00:07:58,250 --> 00:08:01,590 +أي اكتساب underwriting معناها اكتساب لازم يتم من + +117 +00:08:01,590 --> 00:08:03,770 +خلال اللي هو الـ primary markets particularly + +118 +00:08:03,770 --> 00:08:06,750 +investment bank تحديدا هو الـ investment bank + +119 +00:08:06,750 --> 00:08:11,430 +investors get new securities firms get funds اتنوا + +120 +00:08:11,430 --> 00:08:16,430 +احنا طلعنا على الرسم اللي هان خلينا نوضحها ناخد + +121 +00:08:16,430 --> 00:08:20,250 +مثال بسيط على primary markets لو شركة مثلا بدها + +122 +00:08:20,250 --> 00:08:27,110 +تصدر أسهم this company و تكن شركة مثلا Padico، + +123 +00:08:27,110 --> 00:08:32,810 +عارفين شركة Padico؟ شركة Padico، شركة Padico شركة + +124 +00:08:32,810 --> 00:08:36,670 +فلسطينية طبعا، بدهم يصدروا أسهمها، it's a new + +125 +00:08:36,670 --> 00:08:40,690 +issue، يعني إصدار جديد، so they have to go through + +126 +00:08:40,690 --> 00:08:45,580 +the investment bank and then investment bank the .. + +127 +00:08:45,580 --> 00:08:48,200 +the role of investment bank is to market these + +128 +00:08:48,200 --> 00:08:52,580 +securities يعني دور الـ .. الـ .. البنك الاستثمار هو + +129 +00:08:52,580 --> 00:08:57,500 +يعمل تسويق للإصدار طبعا من خلال طبعا هنا هم الـ + +130 +00:08:57,500 --> 00:09:02,080 +public الـ public هم الـ investors الـ public هم الـ + +131 +00:09:02,080 --> 00:09:06,320 +investors المستثمرين okay this is why the .. so if + +132 +00:09:06,320 --> 00:09:09,120 +you look at this chart investment bank is + +133 +00:09:09,120 --> 00:09:11,460 +considered as financial intermediary if you want + +134 +00:09:11,460 --> 00:09:15,500 +to link with the previous chapter لأنه خلينا نحكي + +135 +00:09:15,500 --> 00:09:18,040 +.. نربط الشبات في التلاتة مع بعض الـ investment + +136 +00:09:18,040 --> 00:09:22,480 +bank هذا بيكون الـ previous chapter the badico is + +137 +00:09:22,480 --> 00:09:26,800 +the deficit unit the public is the surplus of the + +138 +00:09:26,800 --> 00:09:30,980 +investors so badico go through the investment bank + +139 +00:09:30,980 --> 00:09:35,520 +investment bank then market the .. so public pay + +140 +00:09:35,520 --> 00:09:42,480 +funds to the .. to the badico so they become as + +141 +00:09:42,480 --> 00:09:42,840 +investors + +142 +00:09:45,970 --> 00:09:50,530 +Okay I discussed this before go back to the + +143 +00:09:50,530 --> 00:09:54,630 +chapter one شرحت الكلام هذا بـ chapter one okay so + +144 +00:09:54,630 --> 00:10:00,930 +just go back to chapter one لأن حكينا احنا حكينا + +145 +00:10:00,930 --> 00:10:06,310 +احنا المرة اللي فاتت chapter one أنه مافي face to + +146 +00:10:06,310 --> 00:10:08,890 +face relationship مافيش علاقة مباشرة في الأسواق + +147 +00:10:08,890 --> 00:10:14,330 +المالية لازم يكون في وسطاء ماليين ففي السوق الأول + +148 +00:10:14,330 --> 00:10:17,950 +لما أنا بضأ أصدر أوراق مالية ASOL مثلا فبديكون في + +149 +00:10:17,950 --> 00:10:23,070 +علاقة مباشرة أول إشي بين الـ badico بين الشركة وبين + +150 +00:10:23,070 --> 00:10:27,530 +الـ investment bank بعدين الـ investment bank they + +151 +00:10:27,530 --> 00:10:30,350 +communicate with the investors هم بيتصفوا مع الـ + +152 +00:10:30,350 --> 00:10:36,310 +investors طيب هل الـ badico محتاجين فلوس؟ Okay + +153 +00:10:36,310 --> 00:10:39,550 +بيصدروا أسهم الـ investment bank بيعمل marketing + +154 +00:10:39,550 --> 00:10:42,530 +للأسهم يعني بيعمل تسويق للأسهم طبعا الـ public they + +155 +00:10:42,530 --> 00:10:46,090 +invest بيشتريوا هذه الأسهم فبصير فيه fund لـ .. لـ + +156 +00:10:46,090 --> 00:10:50,590 +بدك طبعا بالمقابل الـ public بيحصلوا على dividends + +157 +00:10:50,590 --> 00:10:55,070 +بيحصلوا على نسبة أرباح regarding the investment in + +158 +00:10:55,070 --> 00:11:00,790 +.. in the company okay + +159 +00:11:00,790 --> 00:11:04,410 +for secondary market which is different totally + +160 +00:11:04,410 --> 00:11:09,090 +different story Okay the secondary market is + +161 +00:11:09,090 --> 00:11:12,450 +different story القصة بتختلف after meeting the + +162 +00:11:12,450 --> 00:11:16,250 +regulations and instructions of the .. of the + +163 +00:11:16,250 --> 00:11:19,850 +secondary market .. of the primary market then it + +164 +00:11:19,850 --> 00:11:23,130 +might go to the secondary market بعد ما الـ + +165 +00:11:23,130 --> 00:11:25,770 +regulations و الـ instructions بتاعة السوق المالي + +166 +00:11:26,440 --> 00:11:32,160 +يتم تطبيقها مباشرة الأسهم أو السندات أو الأوراق + +167 +00:11:32,160 --> 00:11:37,120 +المالية تنتقل للاتجار في السوق الثانوي Investors + +168 +00:11:37,120 --> 00:11:39,980 +trade previously issued securities among + +169 +00:11:39,980 --> 00:11:43,360 +themselves وفي هاللحظة هذه بيكون المستثمرين + +170 +00:11:43,360 --> 00:11:47,600 +بيبيعوا وبيشتريوا الأسهم من بعض بيبطل في علاقة + +171 +00:11:47,600 --> 00:11:50,000 +للشركة زي ما انتوا شايفين بيصير الـ investors هدول + +172 +00:11:50,000 --> 00:11:55,420 +طلعوا خلصنا الـ investment bank، بيصير في starting + +173 +00:11:55,420 --> 00:11:58,680 +the secondary market، هالـ investor A بده يبيع لـ + +174 +00:11:58,680 --> 00:12:01,140 +investor B، فهذا where .. where they are buying + +175 +00:12:01,140 --> 00:12:04,840 +and selling، they buy and selling in the .. in the + +176 +00:12:04,840 --> 00:12:07,520 +secondary market، they cannot buy and sell + +177 +00:12:07,520 --> 00:12:13,070 +directly they have to go through the dealers or the + +178 +00:12:13,070 --> 00:12:16,890 +brokers which we will talk about these different + +179 +00:12:16,890 --> 00:12:19,810 +types of dealers and brokers later on in this + +180 +00:12:19,810 --> 00:12:23,830 +chapter يعني هدول الناس هتقول الناس لما بيشتريوا + +181 +00:12:23,830 --> 00:12:27,170 +وبيعوا ممنوع يروحوا يشتريوا وبيعوا من بعض مثلا أنا + +182 +00:12:27,170 --> 00:12:30,170 +بعرف مثلا واحدة من البنات معها عندها أسهم لشركة + +183 +00:12:30,170 --> 00:12:32,970 +badicon بس ليش أنا أروح مباشرة اللي هاجيلها أنا + +184 +00:12:32,970 --> 00:12:36,630 +بدي أشتري .. بدي أشتري من شركة badicon لازم نروح + +185 +00:12:36,630 --> 00:12:39,970 +.. we have to go to the .. to the dealer لازم نروح + +186 +00:12:39,970 --> 00:12:45,230 +للـ dealer then we exchange the securities with the + +187 +00:12:45,230 --> 00:12:50,270 +dealer نعمل exchange the securities مع الـ dealer مش + +188 +00:12:50,270 --> 00:12:53,670 +زي ما الواحد بيمتلك مثلا زي ما مثلا بيمتلك mobile + +189 +00:12:53,670 --> 00:12:57,670 +so you are the owner of this mobile you can sell + +190 +00:12:57,670 --> 00:13:02,390 +it directly to the investors or to the public the + +191 +00:13:02,390 --> 00:13:05,350 +financial market cannot work like this الـ + +192 +00:13:05,350 --> 00:13:07,770 +financial market ما تعمل بهذه الطريقة أنه buying + +193 +00:13:07,770 --> 00:13:10,270 +and selling directly لازم يكون في intermediate + +194 +00:13:10,270 --> 00:13:13,630 +institutions to organize the relationship between + +195 +00:13:13,630 --> 00:13:17,430 +buyer and sellers Okay and this is the rule of the + +196 +00:13:17,430 --> 00:13:23,750 +secondary markets Okay what the second .. what the + +197 +00:13:23,750 --> 00:13:29,310 +.. the financial markets .. how we trade in the + +198 +00:13:29,310 --> 00:13:32,830 +primary and the secondary first of all regarding + +199 +00:13:32,830 --> 00:13:36,190 +stocks regarding stocks we have something known as + +200 +00:13:36,190 --> 00:13:41,730 +IPO IPO is stand for initial public offerings I + +201 +00:13:41,730 --> 00:13:42,730 +initial + +202 +00:13:45,780 --> 00:13:53,760 +public offerings it means initial public offerings + +203 +00:13:53,760 --> 00:14:00,700 +it means the first securities issued by the + +204 +00:14:00,700 --> 00:14:05,840 +company it must be it traded in the with the + +205 +00:14:05,840 --> 00:14:09,420 +primary markets and this process known as initial + +206 +00:14:09,420 --> 00:14:13,140 +public offerings so initial public offerings any + +207 +00:14:13,140 --> 00:14:19,220 +newly company أي شركة جديدة it has to go through + +208 +00:14:19,220 --> 00:14:22,280 +the primary markets this process known initial + +209 +00:14:22,280 --> 00:14:26,430 +public offerings initial public اللي هو الاكتتاب + +210 +00:14:26,430 --> 00:14:30,010 +العام بيسموه initial public offering initial + +211 +00:14:30,010 --> 00:14:33,390 +public offering اللي هو الاكتتاب العام طبعا لشركة + +212 +00:14:33,390 --> 00:14:37,590 +جديدة if it is a newly established company this + +213 +00:14:37,590 --> 00:14:39,910 +process known as initial public offerings I will + +214 +00:14:39,910 --> 00:14:41,970 +go in details about the initial public offerings + +215 +00:14:41,970 --> 00:14:50,290 +حنروح بالتفاصيل كمان شوية the second thing of the + +216 +00:14:50,290 --> 00:14:56,200 +stocks seasoned offering what it means seasoned + +217 +00:14:56,200 --> 00:15:00,660 +offerings this issue is for the already + +218 +00:15:00,660 --> 00:15:05,960 +established company but this company needs to .. to + +219 +00:15:05,960 --> 00:15:08,960 +extra funds or to need .. need for .. for + +220 +00:15:08,960 --> 00:15:12,300 +expansion لتعمل توصيات اجتماعية issue a new + +221 +00:15:12,300 --> 00:15:15,500 +securities يعني الفرق بين الأولى والتانية أن هذه + +222 +00:15:15,500 --> 00:15:19,520 +شركة جديدة هذه شركة أصلا موجودة لكن هم منهم يعملوا + +223 +00:15:19,520 --> 00:15:25,160 +إصدار جديد يعني مثلا زي مثلا Baltel or Badico بدهم + +224 +00:15:25,160 --> 00:15:28,680 +يعملوا توسع مثلا، بدهم يشتريوا مثلا new antennas، + +225 +00:15:28,680 --> 00:15:32,720 +بدهم يشتريوا new antennas و .. and it cost them + +226 +00:15:32,720 --> 00:15:35,420 +millions of dollars، بتكلفهم مليون دولارات، so they + +227 +00:15:35,420 --> 00:15:38,780 +think to .. to selling shares أو to issue shares، + +228 +00:15:38,780 --> 00:15:41,960 +يصدروا أسهم، so this process known as seasoned + +229 +00:15:41,960 --> 00:15:45,240 +offering، هاي الطريقة نسميها seasoned offering، + +230 +00:15:45,240 --> 00:15:45,800 +okay؟ + +231 +00:15:49,060 --> 00:15:53,000 +and there is the third one which is a combination + +232 +00:15:53,000 --> 00:15:56,720 +between the bonds and stocks I will talk about the + +233 +00:15:56,720 --> 00:16:02,820 +third one but not now bonds, bonds is similar to + +234 +00:16:02,820 --> 00:16:06,100 +the stocks في بدل ما عندهم الـ initial public + +235 +00:16:06,100 --> 00:16:07,580 +offerings في عندهم الـ public offerings + +236 +00:16:10,600 --> 00:16:13,260 +public offerings public offerings is similar to + +237 +00:16:13,260 --> 00:16:15,640 +the initial public offerings why we call this + +238 +00:16:15,640 --> 00:16:20,100 +public offerings because anyone anyone can buy the + +239 +00:16:20,100 --> 00:16:23,420 +securities this is why it's called public + +240 +00:16:23,420 --> 00:16:28,020 +offerings يعني أنا أنت أي واحد في الجامعة أي واحد + +241 +00:16:28,020 --> 00:16:33,300 +في الشارع أي واحد بيشتغل أي يعني أي إنسان مع ثمن + +242 +00:16:33,300 --> 00:16:36,320 +الـ securities بيقدر يروح يشتريهم so there is no + +243 +00:16:36,320 --> 00:16:40,080 +limitations في بعض الدول تحط limitations على الـ .. + +244 +00:16:40,080 --> 00:16:43,020 +الـ foreign people و الـ local people يعني مثلا إذا + +245 +00:16:43,020 --> 00:16:46,620 +بنحكي أجاري مثلا في السعودية مثلا ممكن يـ .. في + +246 +00:16:46,620 --> 00:16:51,420 +limitations للـ .. للـ non-saudi people فالـ non-Saudi + +247 +00:16:51,420 --> 00:16:54,540 +people they have limitations, they cannot buy + +248 +00:16:54,540 --> 00:16:58,660 +these securities, unlimited securities، في لهم عدد + +249 +00:16:58,660 --> 00:17:03,480 +محدد من الـ securities، if you talk other areas for + +250 +00:17:03,480 --> 00:17:06,020 +instance if you talk about Kuwait and other + +251 +00:17:06,020 --> 00:17:09,580 +countries they... they apply similar regulations + +252 +00:17:09,580 --> 00:17:14,790 +as in the Saudi stock markets okay في بعض الناس لأ + +253 +00:17:14,790 --> 00:17:18,170 +it is open يعني مفتوحة، وأي واحد بيشتري سواء + +254 +00:17:18,170 --> 00:17:21,310 +international people or local people they can buy + +255 +00:17:21,310 --> 00:17:23,650 +and sell the securities يعني بيقدروا يشتريوا و + +256 +00:17:23,650 --> 00:17:28,750 +يبيعوا ال securities private placements private + +257 +00:17:28,750 --> 00:17:34,410 +placements this is this private placements is + +258 +00:17:34,410 --> 00:17:39,170 +issued for a particular people/ particular wealthy + +259 +00:17:39,170 --> 00:17:44,370 +people or a particular wealthy institution هاي ال + +260 +00:17:44,370 --> 00:17:48,450 +private placements ورقة مالية ممكن تكون سند، هاي بس + +261 +00:17:48,450 --> 00:17:50,590 +مش واضحة شوية بالكتاب، خلينا نوضح لكم إياها بس + +262 +00:17:50,590 --> 00:17:53,330 +بالكتاب المحتوط اللي هو private placements ال + +263 +00:17:53,330 --> 00:17:57,130 +private placement لل bonds بس، ممكن نعمل احنا + +264 +00:17:57,130 --> 00:18:01,510 +private placement لل stocks كمان، okay فإيش معنى + +265 +00:18:01,510 --> 00:18:03,550 +private placements private placement اللي احنا + +266 +00:18:03,550 --> 00:18:08,040 +نطرح سند أو نطرح سهم فقط لأشخاص معينين في البلد + +267 +00:18:08,040 --> 00:18:11,040 +they have a good reputation they have a good + +268 +00:18:11,040 --> 00:18:14,780 +prestige they have a good wealth and so on يعني + +269 +00:18:14,780 --> 00:18:21,760 +مثلا عندنا عائلة معينة مثلا في لبنان، okay يتم + +270 +00:18:21,760 --> 00:18:25,300 +إصدار أسهم فقط لهذه العائلة because of the + +271 +00:18:25,300 --> 00:18:28,180 +prestigious of the social position of this family + +272 +00:18:28,180 --> 00:18:34,300 +and this issue is is limited to this family، و هذا + +273 +00:18:34,300 --> 00:18:37,920 +الإصدار فقط لهذه العائلة أو لبعض الناس الموجودين + +274 +00:18:37,920 --> 00:18:41,920 +في هذه العائلة، كمان ممكن يتم إصدار لشركة معينة + +275 +00:18:41,920 --> 00:18:46,560 +يعني أنه أنا... أنا شركة بدكو تروح تصدر أسهم فقط + +276 +00:18:46,560 --> 00:18:50,460 +اشتريها بنك فلسطين، فبسموه private placement، why... + +277 +00:18:50,460 --> 00:18:52,600 +why companies they do this because private + +278 +00:18:52,600 --> 00:18:57,620 +placement is cheaper than yes, so you don't need to + +279 +00:18:57,620 --> 00:19:00,600 +pay a commission or high commission to the + +280 +00:19:00,600 --> 00:19:04,100 +investment bank يعني ما بنضطرّش ندفع كتير + +281 +00:19:04,100 --> 00:19:06,860 +commission لل investment bank so some companies + +282 +00:19:06,860 --> 00:19:10,340 +they prefer to do private placement rather to do + +283 +00:19:10,340 --> 00:19:12,860 +like the initial public offerings or public + +284 +00:19:12,860 --> 00:19:16,000 +offerings العمولة أقل، this is the first thing the + +285 +00:19:16,000 --> 00:19:19,720 +second thing some companies they want to secure a + +286 +00:19:19,720 --> 00:19:22,760 +particular people as a member in their + +287 +00:19:22,760 --> 00:19:26,720 +organization بعض الشركات بفضل أشخاص معينين يكونوا + +288 +00:19:26,720 --> 00:19:29,880 +عندهم في الشركة، so they they do private placement + +289 +00:19:29,880 --> 00:19:34,600 +for them these private placement stocks have هذه + +290 +00:19:34,600 --> 00:19:39,460 +الإصدارات الخاصة، the securities of private + +291 +00:19:39,460 --> 00:19:41,840 +placement are not listed in the financial markets + +292 +00:19:41,840 --> 00:19:44,960 +ممنوع يتم تدوّلها في السوق المالي because this is + +293 +00:19:44,960 --> 00:19:47,980 +just for a particular people يعني بعد ما يتم + +294 +00:19:47,980 --> 00:19:51,280 +الإصدار حتى بالسوق الأولي، هذه ما بتروحش على السوق + +295 +00:19:51,280 --> 00:19:54,760 +الثانوي، وخلاص بتظلها limited يعني هدول الناس ممنوع + +296 +00:19:54,760 --> 00:19:58,620 +يبيعوا، ممنوع يشتريوا في هذه الأسهم، خلاص بتظلها + +297 +00:19:58,620 --> 00:20:01,360 +ملكية اللي هم هدول الناس + +298 +00:20:05,850 --> 00:20:09,010 +بنقش نحكي احتكار، بس عشان نضمن إنهم ضالوا معنا + +299 +00:20:09,010 --> 00:20:15,830 +عشان نضمن إن الشركة هذه تبقى بها المستوى هنا، okay + +300 +00:20:15,830 --> 00:20:21,250 +underwriting + +301 +00:20:21,250 --> 00:20:25,630 +قبل شوية كنا نسمع بال the rule of the investment + +302 +00:20:25,630 --> 00:20:30,700 +bank نرجع نطلعها، هانتطلعوا ال investment bank is + +303 +00:20:30,700 --> 00:20:33,840 +playing the intermediate role between the + +304 +00:20:33,840 --> 00:20:40,660 +companies or the firms and the investors so what + +305 +00:20:40,660 --> 00:20:43,860 +the investors or what is the investment bank + +306 +00:20:43,860 --> 00:20:47,420 +doing؟ the first thing is the underwriting + +307 +00:20:47,420 --> 00:20:53,720 +التغطية، اه بيسموها التغطية الإصدار، the investment + +308 +00:20:53,720 --> 00:20:58,870 +bank has two main underwriting systems، in your + +309 +00:20:58,870 --> 00:21:02,630 +textbook it is just only one يعني في ال textbook + +310 +00:21:02,630 --> 00:21:05,050 +تبعكم فيه نقطة واحدة من الإصدارات اللي بيعملها + +311 +00:21:05,050 --> 00:21:08,230 +investment bank، if in other advanced books there + +312 +00:21:08,230 --> 00:21:11,850 +are at least two في بعض الكتب المتقدمة شوية بال + +313 +00:21:11,850 --> 00:21:14,650 +investment في عندنا نوعين من دور ال investment + +314 +00:21:14,650 --> 00:21:17,350 +bank the first one is the underwriting investment + +315 +00:21:17,350 --> 00:21:19,610 +bank helps the firms to issue and market new + +316 +00:21:19,610 --> 00:21:22,790 +securities يعني بتساعدهم هدول الناس على إنهم + +317 +00:21:22,790 --> 00:21:25,950 +يعملوا إصدارات و يسوقولهم إياها، which known the + +318 +00:21:25,950 --> 00:21:31,550 +general or the well-known type of underwriting is + +319 +00:21:31,550 --> 00:21:37,670 +the firm commitments firm commitments it means the + +320 +00:21:37,670 --> 00:21:44,530 +investment bank sell the securities on behalf of + +321 +00:21:44,530 --> 00:21:49,450 +the companies full commitments full commitments + +322 +00:21:49,450 --> 00:21:53,230 +يعني هم بيروحوا ببيعوا الإصدار بالكامل بالنيابة عن + +323 +00:21:53,230 --> 00:22:00,230 +اللي هو الشركة المصدرة للأسهم، طبعا هاي ال + +324 +00:22:00,230 --> 00:22:04,310 +underwriting في شغل اسمه prospectus prospectus it + +325 +00:22:04,310 --> 00:22:13,350 +means is the guidelines of... of the issue of... + +326 +00:22:13,350 --> 00:22:15,770 +or the underwriting is the guidelines of the + +327 +00:22:15,770 --> 00:22:22,180 +underwriting هي عبارة عن دليل للإصدار، هي إيش بتشمل؟ + +328 +00:22:22,180 --> 00:22:27,080 +بتشمل ال... بتشمل اسم الشركة مثلا، ال objective + +329 +00:22:27,080 --> 00:22:31,780 +الأهداف تبع الشركة، ال strategic tools، ال vision، ال + +330 +00:22:31,780 --> 00:22:36,780 +values، ال aims، the name of trustees، أشخاص الناس + +331 +00:22:36,780 --> 00:22:41,940 +المؤسسين، ال ال areas اللي بنعملوا فيها investment + +332 +00:22:41,940 --> 00:22:45,940 +الأماكن اللي بيعملوا فيها استثمار، طريقة الإصدار + +333 +00:22:45,940 --> 00:22:49,500 +عدد الأسهم، رأس المال المصرح بيه، يعني details about + +334 +00:22:49,500 --> 00:22:53,260 +the the companies and details about the issue or + +335 +00:22:53,260 --> 00:22:56,960 +the underwriting يعني شغلات عامة الشركة و شغلات + +336 +00:22:56,960 --> 00:23:00,840 +بتخص الإصدار نفسه، يعني أكمل سهل بدهم يصدروا؟ مين + +337 +00:23:00,840 --> 00:23:03,060 +بروك الاستثمار اللي هتروح تعملهم تسويق لهذه + +338 +00:23:03,060 --> 00:23:08,120 +الأسهم؟ إلى آخرين which includes prospectus as you + +339 +00:23:08,120 --> 00:23:10,960 +say describe the issue and prospectus of the + +340 +00:23:10,960 --> 00:23:16,360 +company تعمل شغل تاني، الشغلة شو الشركة بتشتغل + +341 +00:23:16,360 --> 00:23:19,540 +أهدافها، استراتيجياتها، ال values تبعتها، مين + +342 +00:23:19,540 --> 00:23:22,080 +المؤسسين تبعونها، إيش ال vision تبعوها، إيه + +343 +00:23:22,080 --> 00:23:25,220 +الأخرين اللي حكيته، و شغلة تانية بتخص الإصدار نفسه، + +344 +00:23:25,220 --> 00:23:29,620 +أكم ساهم بدون مين بنوك الاستثمار و هكذا prospectus + +345 +00:23:29,620 --> 00:23:33,800 +includes the red herring لو أنتو روحتوا على ال... + +346 +00:23:34,850 --> 00:23:37,230 +عال dictionary اللي كتبته red herring، عارفين إيش + +347 +00:23:37,230 --> 00:23:40,950 +معناها red herring؟ red herring معناها ال... زي ال... + +348 +00:23:40,950 --> 00:23:45,010 +...اه؟ ال ranch الحمراء اللي إيش؟ ال ranch الحمراء + +349 +00:23:45,010 --> 00:23:48,790 +اه اللي هي السمكة الحمراء أو بيسموه بتعرفوا ال... + +350 +00:23:48,790 --> 00:23:53,790 +سمك ال... الهمور الهمور أو سمك اللقس يعني بس اللون + +351 +00:23:53,790 --> 00:23:57,450 +أحمر، هذا هذا اسمه ال red herring، طبعا إيش موضوعه؟ + +352 +00:23:57,450 --> 00:24:04,180 +ليش دخل هنا؟ و هو؟ بنك red herring هذا مصطلح قديم + +353 +00:24:04,180 --> 00:24:10,460 +بال financial markets it means the + +354 +00:24:10,460 --> 00:24:14,340 +prospectus is stamped in red يعني ال prospectus + +355 +00:24:14,340 --> 00:24:18,620 +الدليل لسه محطوط عليه ختم بالأحمر، which means the + +356 +00:24:18,620 --> 00:24:24,920 +company should meet the regulations of the of the + +357 +00:24:24,920 --> 00:24:28,840 +stock exchange commission، طبعا في stock exchange + +358 +00:24:28,840 --> 00:24:33,520 +commission اللي هو ال stock exchange I think + +359 +00:24:33,520 --> 00:24:37,540 +commission okay stock exchange commission، لأ اللي + +360 +00:24:37,540 --> 00:24:42,620 +هو لجنة تسويق الإصدار أو لجنة السوق المالي، لأ هيئة + +361 +00:24:42,620 --> 00:24:45,160 +الأوراق المالية اسمها هيئة الأوراق المالية، يعني + +362 +00:24:45,160 --> 00:24:48,820 +موجودة هذه في في سوق فلسطين الأوراق المالية يعني + +363 +00:24:48,820 --> 00:24:53,220 +الهيئة اللي بتنظم الإصدارات، وهي بتكون غالبا هيئة + +364 +00:24:53,220 --> 00:24:58,000 +حكومية، إذا ما كانتش حكومية بتكون هي مرتبطة بالحكومة + +365 +00:24:58,000 --> 00:25:01,260 +بشكل غير مباشر، لازم هم يوافقوا على إيش، يوافقوا + +366 +00:25:01,260 --> 00:25:03,480 +على الإصدار قبل ما يحكوا مع ال investment bank + +367 +00:25:03,480 --> 00:25:08,460 +فهذا ال process بيسموها red herring يعني is a + +368 +00:25:08,460 --> 00:25:11,580 +preliminary of prospectus يعني هي عبارة عن + +369 +00:25:11,580 --> 00:25:16,240 +prospectus لكن first draft يعني إيش first draft؟ + +370 +00:25:16,240 --> 00:25:20,620 +يعني نسخة أولى، الواحد لما بيعمل يعني بيعمل واجب + +371 +00:25:20,620 --> 00:25:22,600 +بيبقى من النسخة الأولى، يعني لسه مش ال final draft + +372 +00:25:22,600 --> 00:25:26,960 +فبيعمل نسخة أولى، subject to some exchange وهي + +373 +00:25:26,960 --> 00:25:31,220 +ممكن يتم التغيير فيها لأنه هي مرتبطة بال + +374 +00:25:31,220 --> 00:25:35,020 +regulations و ال instructions اللي بتتطبق من ال + +375 +00:25:35,020 --> 00:25:39,910 +SEC اللي هو security exchange commission، فبعد ما هم + +376 +00:25:39,910 --> 00:25:44,690 +يقرروا يوافقوا على كل المتطلبات ويقولوا إن الشركة + +377 +00:25:44,690 --> 00:25:51,010 +فعلا يعني طبقت كل المعايير فبيصدروا الـ final + +378 +00:25:51,010 --> 00:25:57,710 +prospectus يعني أول شيء بيردوا الـ red herring الـ + +379 +00:25:57,710 --> 00:26:00,650 +red herring هذه بتكون لسه first draft للـ + +380 +00:26:00,650 --> 00:26:04,450 +prospectus and subject to change يعني مثلا أعطيكم + +381 +00:26:04,450 --> 00:26:07,870 +مثال بسيط لما بيبعتوا الـ prospectus اللي هو الدليل + +382 +00:26:09,240 --> 00:26:13,080 +أول مرة بيسموه red herring بيكون مثلا اسم شخص مش + +383 +00:26:13,080 --> 00:26:17,120 +عاجبهم الحكومة أوه فبيحكيولهم أنه هذا الشخص ما + +384 +00:26:17,120 --> 00:26:20,780 +بيبناش إياكم في هالشركة طب عامين اللي بيحكيلهم + +385 +00:26:20,780 --> 00:26:23,560 +الكلام هذا هيئة الأوراق المالية لأنه because this + +386 +00:26:23,560 --> 00:26:26,300 +is a public company هذه شركة مساهمة عامة so + +387 +00:26:26,300 --> 00:26:28,940 +sometimes the government intervene in the trustees + +388 +00:26:28,940 --> 00:26:37,200 +بتدخلوا في الـ trustees ممكن رأس المال يعني + +389 +00:26:37,200 --> 00:26:43,310 +مثلا أكثر من المطلوب فبالتالي ممكن يتدخلوا في تخفيض + +390 +00:26:43,310 --> 00:26:47,450 +رأس المال ممكن يحكي مثلا some objectives they have + +391 +00:26:47,450 --> 00:26:50,830 +a vague objective يعني أهداف غير واضحة فممكن + +392 +00:26:50,830 --> 00:26:54,850 +يتدخلوا في الأهداف الواضحة كل هذا الأمور بدخل في + +393 +00:26:54,850 --> 00:26:57,970 +الـ red herring بعد ما يعملوا يرتبوا أمور الشركة + +394 +00:26:57,970 --> 00:27:01,310 +ويتم الموافقة they issue the final prospectus + +395 +00:27:01,310 --> 00:27:08,620 +بصدروا الـ final prospectus كيف الاتفاق مع الـ .. الـ + +396 +00:27:08,620 --> 00:27:13,120 +investment bank كيف الشركة بتدفق الشركة هاي مثلا + +397 +00:27:13,120 --> 00:27:16,020 +Badico و لا Battel و لا أي شركة مثلا بتدفق مع الـ + +398 +00:27:16,020 --> 00:27:19,560 +investment bank عادة زي ما أنتم شايفين هاي الشركة + +399 +00:27:19,560 --> 00:27:23,220 +اللي بيبدأ تصدر الإصدار بيسموه issuing فعلا لازم + +400 +00:27:23,220 --> 00:27:27,400 +يكون في واحد اسمه lead underwriter يعني اللي هو + +401 +00:27:27,400 --> 00:27:30,840 +اللي بيقود الإصدار لازم يعني إذا كان investment + +402 +00:27:30,840 --> 00:27:35,670 +bank بتبقى بس هانا الـ chart لو مثلا عندنا احنا شركة + +403 +00:27:35,670 --> 00:27:38,470 +كبيرة مثلا زي IBM و لا شركة General Motors و لا + +404 +00:27:38,470 --> 00:27:42,370 +شركة مثلا جديدة بتتنتشق و .. و رأس المال سبعها + +405 +00:27:42,370 --> 00:27:45,830 +مثلا مليارات الدولارات فبالتالي ممكن الـ investment + +406 +00:27:45,830 --> 00:27:49,250 +bank لوحده one investment bank cannot cover this + +407 +00:27:49,250 --> 00:27:53,030 +process مقدرش يغطي كل هذا الـ process so it is + +408 +00:27:53,030 --> 00:27:56,070 +managed by different investment banks فممكن أكثر + +409 +00:27:56,070 --> 00:27:59,950 +من بنك استثمار يدخل في هذا الـ process فعشان أكثر + +410 +00:27:59,950 --> 00:28:02,050 +يعني لو كان عندنا احنا five investment banks لو + +411 +00:28:02,050 --> 00:28:06,960 +كان عندنا خمسة لازم يكون فيه leader لازم يكون في + +412 +00:28:06,960 --> 00:28:10,740 +واحد leading and coordinating the .. the + +413 +00:28:10,740 --> 00:28:15,660 +underwriting واحد يقود وينسق الـ underwriting فهم + +414 +00:28:15,660 --> 00:28:18,540 +بيختاروا زي ما أنتم موجودين هنا هاي عندنا الـ + +415 +00:28:18,540 --> 00:28:22,260 +leader فعلا اللي هو lead underwriter اللي هو الـ .. + +416 +00:28:22,260 --> 00:28:25,680 +البنك الاستثمار المسؤول الأول والأخير عن إصدار + +417 +00:28:25,680 --> 00:28:28,500 +طبعا في زي ما أنتم شايفين في عندنا كذا bank يعني + +418 +00:28:28,500 --> 00:28:32,670 +هنا إيه؟ Bank A, Bank B, Bank C, Bank D هدول هما + +419 +00:28:32,670 --> 00:28:35,870 +بيكونوا دخلين في عملية الإصدار، بعدين اللي هو + +420 +00:28:35,870 --> 00:28:40,230 +بيروحوا للـ private investors أو لـ public investors + +421 +00:28:40,230 --> 00:28:45,290 +اللي هم المستثمرين اللي بدهم يشتريوا الإصدار okay + +422 +00:28:47,950 --> 00:28:50,410 +الـ investment banking طبعا فهمنا احنا الـ red + +423 +00:28:50,410 --> 00:28:53,810 +herring و الـ prospectus نكمل برضه بالـ .. بالـ .. + +424 +00:28:53,810 --> 00:28:55,910 +بالـ investment bank .. banking وحكينا الـ firm + +425 +00:28:55,910 --> 00:29:01,450 +commitment الـ firm commitment حكيتها قبل شوية أنه + +426 +00:29:01,450 --> 00:29:08,410 +تغطية كاملة بتعهد البنك الاستثمار بشراء أو بتسويق + +427 +00:29:08,410 --> 00:29:13,290 +الإصدار للـ public وحكيت إنه في شغلة .. شغلة ثانية + +428 +00:29:13,290 --> 00:29:16,610 +أو نوع ثاني مش مطلوب منكم في هذا المستوى ممكن فقط + +429 +00:29:16,610 --> 00:29:19,570 +يكون دور البنك الاستثمار هو بيسموها partial + +430 +00:29:19,570 --> 00:29:23,550 +coverage اللي هو التغطية الجزئية يعني يروح فقط هو + +431 +00:29:23,550 --> 00:29:27,810 +مهمته بس يروح يبيع مش مهمته تغطية كاملة وبعد هيك + +432 +00:29:27,810 --> 00:29:34,250 +إذا ما بعش فممكن يـ .. يـ .. يتم مثلا إجراءات أخرى + +433 +00:29:34,250 --> 00:29:37,410 +بالاتفاق مع بنك الاستثمار طيب في هي الـ commitment؟ + +434 +00:29:37,660 --> 00:29:40,340 +investment bank بيشير الـ securities بنك الاستثمار + +435 +00:29:40,340 --> 00:29:42,580 +بيشتري الـ securities from the issuing company + +436 +00:29:42,580 --> 00:29:45,440 +بيشتري من هذه الشركة زي ما أنتم شايفينه على الـ + +437 +00:29:45,440 --> 00:29:48,700 +charts and then resell them to the public يعني + +438 +00:29:48,700 --> 00:29:53,700 +أولا بيروح بنك الاستثمار بيشتري الإصدار كله يعني لو + +439 +00:29:53,700 --> 00:29:58,120 +مثلا شركة جديدة عندها مثلا عشرين مليون دولار بدهم + +440 +00:29:58,120 --> 00:30:04,100 +يصدروهم فبيروح بنك الاستثمار بيشتريهم كلهم وبيروحوا + +441 +00:30:04,100 --> 00:30:09,480 +ببيعهم لـ الـ .. لـ الـ investors أو للـ public فهي + +442 +00:30:09,480 --> 00:30:13,600 +طريقة .. في طرق ثانية طبعا مش مطلوبة منكم لأن فيها + +443 +00:30:13,600 --> 00:30:22,260 +تفاصيل أكثر من الـ .. اه تفضلي يا عفاف وينها؟ الـ اش؟ + +444 +00:30:22,260 --> 00:30:29,100 +تغطية الإصدار الإصدار يعني الأسهم المصدرة أو + +445 +00:30:29,100 --> 00:30:33,020 +الأوراق المالية المصدرة طبعا بتعهد أول شيء بشتريها + +446 +00:30:33,020 --> 00:30:41,980 +وبعدين بيروح ببيعها طبعا بناخد بالنا هنا يا بنات أن + +447 +00:30:41,980 --> 00:30:48,000 +الـ IBO is good for investment هو كثير كويس + +448 +00:30:48,000 --> 00:30:52,980 +للاستثمار حسب الحالة اللي بتصير عن الـ IBO لأنه + +449 +00:30:52,980 --> 00:31:01,980 +عادة الـ investment bankas .. as the .. they manage + +450 +00:31:01,980 --> 00:31:07,500 +the .. the underwriting they issue .. they .. they + +451 +00:31:07,500 --> 00:31:11,040 +issue the securities below the predicted price + +452 +00:31:11,040 --> 00:31:16,140 +يعني إذا كان سعر السهم في السوق مثلا عشرين دولار + +453 +00:31:16,140 --> 00:31:20,300 +فهم بيحاولوا ينزلوا السعر مثلا لخمسة عشر to encourage + +454 +00:31:20,300 --> 00:31:23,700 +.. to encourage investors to buy the .. the + +455 +00:31:23,700 --> 00:31:28,450 +underwriting عشان يشجعوهم لكن هذا لا يعني أن + +456 +00:31:28,450 --> 00:31:32,330 +الشركات كل شركات الاستثمار هتعمل لك لأ some + +457 +00:31:32,330 --> 00:31:36,150 +companies they do this طيب بالـ investment banking + +458 +00:31:36,150 --> 00:31:38,810 +process we have something is known shelf + +459 +00:31:38,810 --> 00:31:44,210 +registration okay shelf يعني التسجيل طبعا هي + +460 +00:31:44,210 --> 00:31:51,530 +التسجيل التسجيل الشركات انتبهوا + +461 +00:31:51,530 --> 00:31:55,370 +أنا حكيت أنا الـ SEC اللي هو security exchange + +462 +00:31:55,370 --> 00:32:00,590 +commission في عندها role رقم 415 وهذا الـ role فيه + +463 +00:32:00,590 --> 00:32:04,050 +role .. role مشابه له أو مشابه أنه في سوق فلسطين + +464 +00:32:04,050 --> 00:32:07,330 +أوراق المالية يعني تقريبا نفس التعليمات والتوجيهات + +465 +00:32:07,330 --> 00:32:11,810 +هذا shelf registration إيش معناه allows firm to + +466 +00:32:11,810 --> 00:32:14,930 +register securities and gradually sell them to the + +467 +00:32:14,930 --> 00:32:20,550 +public for two years مسموح للشركة أنه + +468 +00:32:23,640 --> 00:32:28,200 +يتم تسجيل الـ securities في هيئة الأوراق المالية و + +469 +00:32:28,200 --> 00:32:32,360 +خلال فترة سنتين لازم هذه الشركة تنتقل للـ primary + +470 +00:32:32,360 --> 00:32:37,660 +markets لأ معهم two years يعني بيبدؤوا يبيعوا الـ .. + +471 +00:32:37,660 --> 00:32:40,120 +الـ .. الأسهم للـ .. أو الـ securities للـ investors + +472 +00:32:40,120 --> 00:32:45,600 +within two years خلال سنتين the company or the + +473 +00:32:45,600 --> 00:32:49,810 +securities should go to the secondary markets they + +474 +00:32:49,810 --> 00:32:53,290 +have to apply the regulations and instructions of + +475 +00:32:53,290 --> 00:32:57,450 +the SEC لازم يطبقوا الـ .. الـ regulations what + +476 +00:32:57,450 --> 00:32:59,610 +these regulations شو هذه الـ regulations for + +477 +00:32:59,610 --> 00:33:03,170 +instance they have to issue to a profitable income + +478 +00:33:03,170 --> 00:33:07,550 +statement مثلا واحدة من التعليمات لازم يصدروا + +479 +00:33:07,550 --> 00:33:11,650 +سنتين أرباح تحقيق أرباح أو بيسموها income + +480 +00:33:11,650 --> 00:33:15,850 +statement لازم يصدروا سنتين فيها أرباح تمام؟ لازم + +481 +00:33:15,850 --> 00:33:19,230 +يكون مثلا الـ .. الـ liquidity ratios الـ activity + +482 +00:33:19,230 --> 00:33:22,630 +ratios الـ .. الـ leverage ratios and is acceptable + +483 +00:33:22,630 --> 00:33:27,030 +يعني التحليل المالي تبع الشركة تحليل وضع جيد الـ + +484 +00:33:27,030 --> 00:33:30,170 +market شركتها بقتها مقبولة بعد هيك إذا صار في + +485 +00:33:30,170 --> 00:33:35,030 +الشروط هذه ممكن تروح على الـ secondary markets فهي + +486 +00:33:35,030 --> 00:33:39,110 +.. هي .. هي الخطوة بيسموها shelf registration يعني + +487 +00:33:39,110 --> 00:33:42,830 +بيروح بسجله في الـ .. في هيئة الأوراق المالية and + +488 +00:33:42,830 --> 00:33:45,050 +they are waiting to be in the secondary market + +489 +00:33:45,050 --> 00:33:48,690 +يعني هم they are in the queue يعني بيظلوا سنتين مش + +490 +00:33:48,690 --> 00:33:52,610 +دخلين في السوق المالي العادي بيظلوا لمدة سنتين برا + +491 +00:33:52,610 --> 00:33:57,730 +السوق لكن مسجلين هم ما فيه حتى يكتمل الشروط و تروح + +492 +00:33:57,730 --> 00:34:02,990 +على السوق المالي الثانوي within two years in some + +493 +00:34:02,990 --> 00:34:07,430 +countries they ask for three years في بعض الدول + +494 +00:34:07,430 --> 00:34:09,630 +ممكن .. بعد ثلاث سنوات + +495 +00:34:15,240 --> 00:34:21,000 +زي ما هي بقى؟ زي من الأولى .. زي من الأولى بعد سنة + +496 +00:34:21,000 --> 00:34:23,540 +بيشوفون علم علشان دي وبعدين بيروحوا على الـ + +497 +00:34:23,540 --> 00:34:24,540 +secondary market بيروحوا على الـ secondary market + +498 +00:34:24,540 --> 00:34:28,160 +فهي الـ .. الـ .. الـ .. الـ queue عارفة إيش معنى + +499 +00:34:28,160 --> 00:34:31,340 +queue، queue يعني بالانتظار، بكونوا هيبقوا بالانتظار + +500 +00:34:31,340 --> 00:34:34,960 +لازم أنه يكون عندهم وضع مالي كويس ولازم يكون + +501 +00:34:34,960 --> 00:34:41,100 +عندهم تقارير مالية جيدة وبعد هيك بيروحوا على ال + +502 +00:34:41,100 --> 00:34:41,940 +secondary markets + +503 +00:34:46,730 --> 00:34:50,430 +بالـ .. اه بي .. بيصير .. طبعًا بيفرق كثير لإنه + +504 +00:34:50,430 --> 00:34:54,050 +ممنوع يصير trade ممنوع يصير التجارة في أسهمها + +505 +00:34:54,050 --> 00:34:59,090 +بيصير + +506 +00:34:59,090 --> 00:35:01,710 +لما يقع .. اه بالظبط بيصير .. بيصير أعمالية بيع + +507 +00:35:01,710 --> 00:35:05,510 +داخلية بين المستثمرين، تمام؟ لكن مش بالطريقة اللي + +508 +00:35:05,510 --> 00:35:10,030 +بيصير فيها الـ secondary markets، تمام؟ + +509 +00:35:10,030 --> 00:35:15,150 +طيب طب ما عاد الحل، احنا بـ .. we just end هذا الحل diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/4qmkBLfi5sY_postprocess.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/4qmkBLfi5sY_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..86c206c6ebe39eccd03bc9b9fa3893d6287f7c9d --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/4qmkBLfi5sY_postprocess.srt @@ -0,0 +1,2036 @@ +1 +00:00:21,340 --> 00:00:25,640 +اليوم احنا هنحكي ب chapter three which .. which + +2 +00:00:25,640 --> 00:00:31,620 +about how securities are traded okay خلينا ناخد بس + +3 +00:00:31,620 --> 00:00:36,420 +ملخص ل chapter one و chapter two عشان احنا نمشي ب + +4 +00:00:36,420 --> 00:00:41,660 +chapter three ب chapter one we talk about the .. + +5 +00:00:41,660 --> 00:00:43,960 +the main differences between financial assets and + +6 +00:00:43,960 --> 00:00:49,180 +real assetsوالقصة الثالثة تحتوي على ثلاث نقطة + +7 +00:00:49,180 --> 00:00:52,160 +الرئيسية والأولى هي الفرق الرئيسي بين الواحدة + +8 +00:00:52,160 --> 00:00:55,240 +المالية والواحدة الحقيقية والنقطة الثانية هي + +9 +00:00:55,240 --> 00:01:00,240 +التعامل بين الواحدة المالية والواحدة الاقتصادية أو + +10 +00:01:00,240 --> 00:01:04,280 +الواحدة المالية الاقتصادية والنقطة الثالثة مرتبطة + +11 +00:01:04,280 --> 00:01:10,550 +مع كيفThe investors process their investments or + +12 +00:01:10,550 --> 00:01:13,390 +the investment process So these are the three main + +13 +00:01:13,390 --> 00:01:17,270 +points we talk about in chapter one In chapter two + +14 +00:01:17,270 --> 00:01:21,250 +it is mainly focused on the main difference + +15 +00:01:21,250 --> 00:01:24,330 +between the money market instruments and the + +16 +00:01:24,330 --> 00:01:26,810 +capital market instruments So you should know + +17 +00:01:26,810 --> 00:01:30,030 +about the main characteristics of the money market + +18 +00:01:30,030 --> 00:01:33,070 +instruments or tools and the capital market + +19 +00:01:33,070 --> 00:01:36,340 +instruments and toolstoday I'm going to talk about + +20 +00:01:36,340 --> 00:01:40,520 +how these securities which is discussed in chapter + +21 +00:01:40,520 --> 00:01:42,920 +one and chapter two how these securities are + +22 +00:01:42,920 --> 00:01:45,440 +traded in the financial markets يعني كيف هاي ال + +23 +00:01:45,440 --> 00:01:51,500 +tools هاي ال instruments كيف احنا تم تدولها في + +24 +00:01:51,500 --> 00:01:55,520 +الأسواق المالية okay which is more practical + +25 +00:01:55,520 --> 00:02:01,130 +chapter هذا chapter practicalit includes some + +26 +00:02:01,130 --> 00:02:04,150 +regulations and some instructions on how to trade + +27 +00:02:04,150 --> 00:02:06,410 +in the financial markets يعني هي في بعض ال + +28 +00:02:06,410 --> 00:02:11,970 +instructions بعض التعليمات والتوجيهات اللي كيف أنه + +29 +00:02:11,970 --> 00:02:16,170 +احنا نستخدمه في الأسواق المالية it mainly depends + +30 +00:02:16,170 --> 00:02:19,130 +on the .. the .. the regulations and instructions + +31 +00:02:19,130 --> 00:02:21,990 +in the United Statesهي بتعتمد على ال regulations + +32 +00:02:21,990 --> 00:02:25,010 +الموجودة بال United States however most of these + +33 +00:02:25,010 --> 00:02:27,590 +regulations are applied in the Palestine Stock + +34 +00:02:27,590 --> 00:02:30,970 +Exchange كل أغلب ال regulations هذه اللي احنا + +35 +00:02:30,970 --> 00:02:33,670 +هبنحكي فيها هي مطبقة في صور خلاصين الأوراق المالية + +36 +00:02:33,670 --> 00:02:37,010 +so we don't have .. we .. we don't have major + +37 +00:02:37,010 --> 00:02:40,150 +differences between the regulations applied in the + +38 +00:02:40,150 --> 00:02:42,830 +United States and the regulations applied in the + +39 +00:02:42,830 --> 00:02:46,320 +.. in the .. in the Palestine Stock ExchangeSo + +40 +00:02:46,320 --> 00:02:49,540 +don't get confused about these regulations So + +41 +00:02:49,540 --> 00:02:53,300 +these regulations mainly important for the + +42 +00:02:53,300 --> 00:02:56,120 +investors because they should consider these + +43 +00:02:56,120 --> 00:02:58,660 +regulations before taking any action in the + +44 +00:02:58,660 --> 00:03:02,860 +position يعني هم المستثمرين لازم ياخدوا بالهم من + +45 +00:03:02,860 --> 00:03:06,860 +هذه ال regulations قبل ما هم يروحوا يفكروا + +46 +00:03:06,860 --> 00:03:09,720 +بالاستثمارات So our subject today is how + +47 +00:03:09,720 --> 00:03:13,160 +securities are traded So I will give you + +48 +00:03:15,880 --> 00:03:19,400 +The main difference between the primary market and + +49 +00:03:19,400 --> 00:03:23,260 +the secondary market which is the first important + +50 +00:03:23,260 --> 00:03:24,660 +point in this chapter + +51 +00:03:31,170 --> 00:03:35,890 +the first thing how firms issue securities كيف + +52 +00:03:35,890 --> 00:03:43,350 +الشركات بتصدر الأوراق المالية اي سوق مالي في + +53 +00:03:43,350 --> 00:03:48,710 +العالم او اي ورقة مالية لازم تكون فيها two steps + +54 +00:03:48,710 --> 00:03:51,370 +to be in the financial markets لازم يكون في two + +55 +00:03:51,370 --> 00:03:54,390 +steps or two stages two stages to be in the + +56 +00:03:54,390 --> 00:03:58,430 +financial markets لازم تمر في مرحلتينI'm talking + +57 +00:03:58,430 --> 00:04:01,690 +about the public limited companies I'm not talking + +58 +00:04:01,690 --> 00:04:04,550 +about the private limited company أنا بحكي عن + +59 +00:04:04,550 --> 00:04:06,930 +الشركات المساهمة العامة I'm not talking about the + +60 +00:04:06,930 --> 00:04:09,330 +private limited company ومابحكيش عن الشركات + +61 +00:04:09,330 --> 00:04:12,010 +المساهمة المحدودة okay I think this is in the + +62 +00:04:12,010 --> 00:04:15,450 +business research or in the business studies you + +63 +00:04:15,450 --> 00:04:18,170 +have a good knowledge on the main differences + +64 +00:04:18,170 --> 00:04:21,950 +between the corporations so I don't want to go + +65 +00:04:21,950 --> 00:04:25,390 +back to the businessstudies so in your free time + +66 +00:04:25,390 --> 00:04:28,210 +you can go back and read about the main + +67 +00:04:28,210 --> 00:04:31,630 +differences of these corporations يعني هذا الموضوع + +68 +00:04:31,630 --> 00:04:35,110 +أنه احنا هنحكي عن شركات مساهمة عامة مش هنحكي عن + +69 +00:04:35,110 --> 00:04:38,010 +شركات مساهمة محدودة شركات مساهمة محدودة و other + +70 +00:04:38,010 --> 00:04:42,670 +types of corporations و الأنواع الأخرى من الشركات + +71 +00:04:42,670 --> 00:04:46,010 +مثل ال solid trader and others هي أصلا أنت درستها + +72 +00:04:46,010 --> 00:04:49,310 +أنت درستوها في دراسات تجارية ففي الوقت الضائع في + +73 +00:04:49,310 --> 00:04:54,220 +الوقت ال ..نحكي ال free time تبعكم ممكن ترجعوا + +74 +00:04:54,220 --> 00:04:57,940 +لدراسات تجارية and you are you seeking the + +75 +00:04:57,940 --> 00:05:03,240 +knowledge from there okay so I'm + +76 +00:05:03,240 --> 00:05:06,680 +talking about the two stages the first stage any + +77 +00:05:06,680 --> 00:05:11,160 +security must be in the primary market this is the + +78 +00:05:11,160 --> 00:05:13,940 +first thing any security it doesn't matter if this + +79 +00:05:13,940 --> 00:05:16,480 +security is issued by the government by + +80 +00:05:16,480 --> 00:05:21,060 +corporation by any other institutionit must be go + +81 +00:05:21,060 --> 00:05:24,700 +through the primary markets then after the primary + +82 +00:05:24,700 --> 00:05:29,920 +market it go or it might go to the secondary + +83 +00:05:29,920 --> 00:05:33,740 +markets why I say it might go because it is not + +84 +00:05:33,740 --> 00:05:37,400 +necessary that all of the securities will go to + +85 +00:05:37,400 --> 00:05:42,480 +the secondary markets unless unless they meet the + +86 +00:05:42,480 --> 00:05:44,700 +regulations and the instructions of the financial + +87 +00:05:44,700 --> 00:05:49,510 +marketsيعني فقط بروح على ال secondary market السوق + +88 +00:05:49,510 --> 00:05:55,470 +الثانوي لما يطبقوا كل المعايير اللي مطلوبة من اللي + +89 +00:05:55,470 --> 00:06:00,630 +هي ال .. ال .. ال ESC ESC أنا هنشرح في الكلام هذا + +90 +00:06:00,630 --> 00:06:03,790 +في التفاصيل so just to summarize any financial .. + +91 +00:06:03,790 --> 00:06:06,950 +any security should go through the primary markets + +92 +00:06:06,950 --> 00:06:11,550 +okay then after that to the secondary markets + +93 +00:06:15,570 --> 00:06:18,570 +The secondary market is the normal market that you + +94 +00:06:18,570 --> 00:06:22,290 +are talking about هو الشكل العادى اللي هو ال .. + +95 +00:06:22,290 --> 00:06:24,870 +اللي هو السوق العادي اللي احنا بنعرفه دائما في + +96 +00:06:24,870 --> 00:06:28,450 +الأخبار اللي هو نحكي عن Dow Jones، نحكي عن NASDAQ، + +97 +00:06:28,450 --> 00:06:30,290 +نحكي عن New York Stock Exchange، نحكي عن سوق + +98 +00:06:30,290 --> 00:06:33,150 +فلسطين الأوراق المالية، نحكي عن سوق القاهرة، نحكي + +99 +00:06:33,150 --> 00:06:36,410 +عن سوق خمان، هدول بيسموهم secondary markets The + +100 +00:06:36,410 --> 00:06:39,230 +primary market is running by the investment bank + +101 +00:06:39,230 --> 00:06:44,610 +ال investment bankis in charge to market the + +102 +00:06:44,610 --> 00:06:49,030 +securities in the primary markets يعني البنك + +103 +00:06:49,030 --> 00:06:54,090 +الاستثمار هو المسئول على الأسواق المالية الأولية + +104 +00:06:54,090 --> 00:07:02,290 +لأن من خلاله the securities are markets to the + +105 +00:07:02,290 --> 00:07:07,090 +investors لال investors يعني إذا كان عندنا أي شركة + +106 +00:07:07,090 --> 00:07:11,300 +بدأت تصدر شركة ولا حكومة بدأت تصدر أي securityAny + +107 +00:07:11,300 --> 00:07:15,700 +security it must go to the .. to the investment + +108 +00:07:15,700 --> 00:07:20,080 +bank IB IB is stand for the investment bank and + +109 +00:07:20,080 --> 00:07:22,580 +then this is the .. the investors then the + +110 +00:07:22,580 --> 00:07:31,820 +investors buying the securities okay اتفضل اتفضل + +111 +00:07:31,820 --> 00:07:39,950 +اتفضل اتفضلبس بناء على طرح ال combo شركة okay so + +112 +00:07:39,950 --> 00:07:44,470 +primary markets I'm talking about .. سوري أنا حكيت + +113 +00:07:44,470 --> 00:07:47,650 +عن ال primary market اه okay ال primary market + +114 +00:07:47,650 --> 00:07:51,370 +فهمش ايش و نيه ال securities through underwriting + +115 +00:07:51,370 --> 00:07:58,250 +to public يعني اي إصدار ماليأي إصدار أوراق مالية + +116 +00:07:58,250 --> 00:08:01,590 +أي اكتساب underwriting معناها اكتساب لازم يتم من + +117 +00:08:01,590 --> 00:08:03,770 +خلال اللي هو ال primary markets particularly + +118 +00:08:03,770 --> 00:08:06,750 +investment bank تحديدا هو ال investment bank + +119 +00:08:06,750 --> 00:08:11,430 +investors get new securities firms get funds اتنوا + +120 +00:08:11,430 --> 00:08:16,430 +احنا طلعنا على الرسم اللي هان خلينا نوضحها ناخد + +121 +00:08:16,430 --> 00:08:20,250 +مثال بسيط على primary markets لو شركة مثلا بدها + +122 +00:08:20,250 --> 00:08:27,110 +تصدر أسهم this company و تكن شركة مثلاPadico، + +123 +00:08:27,110 --> 00:08:32,810 +عارفين شركة Padico؟ شركة Padico، شركة Padico شركة + +124 +00:08:32,810 --> 00:08:36,670 +فلسطينية طبعا، بدهم يصدروا أسمنة، it's a new + +125 +00:08:36,670 --> 00:08:40,690 +issue، يعني إصدار جديد، so they have to go through + +126 +00:08:40,690 --> 00:08:45,580 +the investment bankand then investment bank the .. + +127 +00:08:45,580 --> 00:08:48,200 +the role of investment bank is to market these + +128 +00:08:48,200 --> 00:08:52,580 +securities يعني دور ال .. ال .. البنك الاستثمار هو + +129 +00:08:52,580 --> 00:08:57,500 +يعمل تسويق للإصدار طبعا من خلال طبعا هنا هم ال + +130 +00:08:57,500 --> 00:09:02,080 +public ال public هم ال investorsالpublic هم ال + +131 +00:09:02,080 --> 00:09:06,320 +investors المستثمرين okay this is why the .. so if + +132 +00:09:06,320 --> 00:09:09,120 +you look at this chart investment bank is + +133 +00:09:09,120 --> 00:09:11,460 +considered as financial intermediary if you want + +134 +00:09:11,460 --> 00:09:15,500 +to link with the previous chapterلأنه خلينا نحكي + +135 +00:09:15,500 --> 00:09:18,040 +.. نربط الشبات في التلاتة مع بعض ال investment + +136 +00:09:18,040 --> 00:09:22,480 +bank هذا بيكون ال previous chapter the badico is + +137 +00:09:22,480 --> 00:09:26,800 +the deficit unit the public is the surplus of the + +138 +00:09:26,800 --> 00:09:30,980 +investors so badico go through the investment bank + +139 +00:09:30,980 --> 00:09:35,520 +investment bank then market the .. so public pay + +140 +00:09:35,520 --> 00:09:42,480 +funds to the .. to the badico so they become as + +141 +00:09:42,480 --> 00:09:42,840 +investors + +142 +00:09:45,970 --> 00:09:50,530 +Okay I discussed this before go back to the + +143 +00:09:50,530 --> 00:09:54,630 +chapter one شرحت الكلام هذا ب chapter one okay so + +144 +00:09:54,630 --> 00:10:00,930 +just go back to chapter one لأن حكينا احناحكينا + +145 +00:10:00,930 --> 00:10:06,310 +احنا المرة اللي فاتت chapter one انه مافي face to + +146 +00:10:06,310 --> 00:10:08,890 +face relationship مافيش علاقة مباشرة في الأسواق + +147 +00:10:08,890 --> 00:10:14,330 +المالية لازم يكون في وسطاء ماليين ففي السوق الأول + +148 +00:10:14,330 --> 00:10:17,950 +لما انا بضأ أصدر أوراق مالية ASOL مثلا فبديكون في + +149 +00:10:17,950 --> 00:10:23,070 +علاقة مباشرةأول إشي بين ال badico بين الشركة وبين + +150 +00:10:23,070 --> 00:10:27,530 +ال investment bank بعدين ال investment bank they + +151 +00:10:27,530 --> 00:10:30,350 +communicate with the investors هم بيتصفوا مع ال + +152 +00:10:30,350 --> 00:10:36,310 +investors طيب هل ال badico محتاجين فلوس؟Okay + +153 +00:10:36,310 --> 00:10:39,550 +بيصدروا أسهم ال investment bank بيعمل marketing + +154 +00:10:39,550 --> 00:10:42,530 +للأسهم يعني بيعمل تسويق للأسهم طبعا ال public they + +155 +00:10:42,530 --> 00:10:46,090 +invest بيشتريوا هذه الأسهم فبصير فيه fund ل .. ل + +156 +00:10:46,090 --> 00:10:50,590 +بدك طبعا بالمقابل ال public بيحصلوا على dividends + +157 +00:10:50,590 --> 00:10:55,070 +بيحصلوا على نسبة أرباح regarding the investment in + +158 +00:10:55,070 --> 00:11:00,790 +.. in the company okay + +159 +00:11:00,790 --> 00:11:04,410 +for secondary market which is different totally + +160 +00:11:04,410 --> 00:11:09,090 +different storyOkay the secondary market is + +161 +00:11:09,090 --> 00:11:12,450 +different story القصة بتختلف after meeting the + +162 +00:11:12,450 --> 00:11:16,250 +regulations and instructions of the .. of the + +163 +00:11:16,250 --> 00:11:19,850 +secondary market .. of the primary market then it + +164 +00:11:19,850 --> 00:11:23,130 +might go to the secondary market بعد ما ال + +165 +00:11:23,130 --> 00:11:25,770 +regulations و ال instructions بتاعة السوق المالي + +166 +00:11:26,440 --> 00:11:32,160 +يتم تطبيقها مباشرة الأسهم أو السندات أو الأوراق + +167 +00:11:32,160 --> 00:11:37,120 +المالية تنتقل للاتجار في السوق الثانوي Investors + +168 +00:11:37,120 --> 00:11:39,980 +trade previously issued securities among + +169 +00:11:39,980 --> 00:11:43,360 +themselves وفي هاللحظة هذه بيكون المستثمرين + +170 +00:11:43,360 --> 00:11:47,600 +بيبيعوا وبيشتريوا الأسهم من بعض بيبطل في علاقة + +171 +00:11:47,600 --> 00:11:50,000 +للشركة زي ما انتوا شايفين بيصير ال investors هدول + +172 +00:11:50,000 --> 00:11:55,420 +طلعواخلصنا ال investment bank، بيصير في starting + +173 +00:11:55,420 --> 00:11:58,680 +the secondary market، هال investor A بده يبيع ل + +174 +00:11:58,680 --> 00:12:01,140 +investor B، فهذا where .. where they are buying + +175 +00:12:01,140 --> 00:12:04,840 +and selling، they buy and selling in the .. in the + +176 +00:12:04,840 --> 00:12:07,520 +secondary market، they cannot buy and sell + +177 +00:12:07,520 --> 00:12:13,070 +directlythey have to go through the dealers or the + +178 +00:12:13,070 --> 00:12:16,890 +brokers which we will talk about these different + +179 +00:12:16,890 --> 00:12:19,810 +types of dealers and brokers later on in this + +180 +00:12:19,810 --> 00:12:23,830 +chapter يعني هدول الناسهتقول الناس لما بيشتريوا + +181 +00:12:23,830 --> 00:12:27,170 +وبيعوا ممنوع يروحوا يشتريوا وبيعوا من بعض مثلا انا + +182 +00:12:27,170 --> 00:12:30,170 +بعرف مثلا واحدة من البنات معها عندها أسهم لشركة + +183 +00:12:30,170 --> 00:12:32,970 +badicon بس ليش انا أروح مباشرة اللي هاجيلها انا + +184 +00:12:32,970 --> 00:12:36,630 +بدي اشتري .. بدي أشتري من شركة badicon لازم نروح + +185 +00:12:36,630 --> 00:12:39,970 +.. we have to go to the .. to the dealer لازم نروح + +186 +00:12:39,970 --> 00:12:45,230 +لل dealer then we exchange the securities with the + +187 +00:12:45,230 --> 00:12:50,270 +dealerنعمل exchange the securities مع ال dealer مش + +188 +00:12:50,270 --> 00:12:53,670 +زي ما الواحد بيمتلك مثلا زي ما مثلا بيمتلك mobile + +189 +00:12:53,670 --> 00:12:57,670 +so you are the owner of this mobile you can sell + +190 +00:12:57,670 --> 00:13:02,390 +it directly to the investors or to the public the + +191 +00:13:02,390 --> 00:13:05,350 +financial market cannot work like this ال + +192 +00:13:05,350 --> 00:13:07,770 +financial market ماتعمل بهذه الطريقة انه buying + +193 +00:13:07,770 --> 00:13:10,270 +and selling directly لازم يكون في intermediate + +194 +00:13:10,270 --> 00:13:13,630 +institutions to organize the relationship between + +195 +00:13:13,630 --> 00:13:17,430 +buyer and sellersOkay and this is the rule of the + +196 +00:13:17,430 --> 00:13:23,750 +secondary markets Okay what the second .. what the + +197 +00:13:23,750 --> 00:13:29,310 +.. the financial markets .. how we trade in the + +198 +00:13:29,310 --> 00:13:32,830 +primary and the secondary first of all regarding + +199 +00:13:32,830 --> 00:13:36,190 +stocks regarding stocks we have something known as + +200 +00:13:36,190 --> 00:13:41,730 +IPO IPO is stand for initial public offerings I + +201 +00:13:41,730 --> 00:13:42,730 +initial + +202 +00:13:45,780 --> 00:13:53,760 +public offerings it means initial public offerings + +203 +00:13:53,760 --> 00:14:00,700 +it means the first securities issued by the + +204 +00:14:00,700 --> 00:14:05,840 +company it must beit traded in the with the + +205 +00:14:05,840 --> 00:14:09,420 +primary markets and this process known as initial + +206 +00:14:09,420 --> 00:14:13,140 +public offerings so initial public offerings any + +207 +00:14:13,140 --> 00:14:19,220 +newly company أي شركة جديدة it has to go through + +208 +00:14:19,220 --> 00:14:22,280 +the primary markets this process known initial + +209 +00:14:22,280 --> 00:14:26,430 +public offeringsinitial public اللي هو الاكتتاب + +210 +00:14:26,430 --> 00:14:30,010 +العام بيسموه initial public offering initial + +211 +00:14:30,010 --> 00:14:33,390 +public offering اللي هو الاكتتاب العام طبعا لشركة + +212 +00:14:33,390 --> 00:14:37,590 +جديدة if it is a newly established company this + +213 +00:14:37,590 --> 00:14:39,910 +process known as initial public offerings I will + +214 +00:14:39,910 --> 00:14:41,970 +go in details about the initial public offerings + +215 +00:14:41,970 --> 00:14:50,290 +حنروح بالتفاصيل كمان شوية the second thing of the + +216 +00:14:50,290 --> 00:14:56,200 +stocksseasons offering what it means season + +217 +00:14:56,200 --> 00:15:00,660 +offerings this issue is for the already + +218 +00:15:00,660 --> 00:15:05,960 +established companybut this company needs to .. to + +219 +00:15:05,960 --> 00:15:08,960 +extra funds or to need .. need for .. for + +220 +00:15:08,960 --> 00:15:12,300 +expansion لتعمل توصيات اجتماعية issue a new + +221 +00:15:12,300 --> 00:15:15,500 +securities يعني الفرق بين الأولى والتانية أن هذه + +222 +00:15:15,500 --> 00:15:19,520 +شركة جديدة هذه شركة أصلا موجودة لكن هم منهم يعملوا + +223 +00:15:19,520 --> 00:15:25,160 +إصدار جديد يعني مثلا زي مثلا Baltel or Badicoبدهم + +224 +00:15:25,160 --> 00:15:28,680 +يعملوا توسع مثلا، بدهم يشتريوا مثلا new antennas، + +225 +00:15:28,680 --> 00:15:32,720 +بدهم يشتريوا new antennas و .. and it cost them + +226 +00:15:32,720 --> 00:15:35,420 +million of dollar، بتكلفهم مليون دولارات، so they + +227 +00:15:35,420 --> 00:15:38,780 +think to .. to selling shares أو to issue shares، + +228 +00:15:38,780 --> 00:15:41,960 +يصدروا أسهم، so this process known as seasoned + +229 +00:15:41,960 --> 00:15:45,240 +offering، هاي الطريقة نسميها seasoned offering، + +230 +00:15:45,240 --> 00:15:45,800 +okay؟ + +231 +00:15:49,060 --> 00:15:53,000 +and there is the third one which is a combination + +232 +00:15:53,000 --> 00:15:56,720 +between the bonds and stocks I will talk about the + +233 +00:15:56,720 --> 00:16:02,820 +third one but not now bonds, bonds is similar to + +234 +00:16:02,820 --> 00:16:06,100 +the stocks في بدل ما عندهم ال initial public + +235 +00:16:06,100 --> 00:16:07,580 +offerings في عندهم ال public offerings + +236 +00:16:10,600 --> 00:16:13,260 +public offerings public offerings is similar to + +237 +00:16:13,260 --> 00:16:15,640 +the initial public offerings why we call this + +238 +00:16:15,640 --> 00:16:20,100 +public offerings because anyone anyone can buy the + +239 +00:16:20,100 --> 00:16:23,420 +securities this is why it's called public + +240 +00:16:23,420 --> 00:16:28,020 +offerings يعني أنا أنت أي واحد في الجامعة أي واحد + +241 +00:16:28,020 --> 00:16:33,300 +في الشارع أي واحد بيشتغل أي يعني أي إنسان مع ثمن + +242 +00:16:33,300 --> 00:16:36,320 +ال securities بيقدر يروح يشتريهمso there is no + +243 +00:16:36,320 --> 00:16:40,080 +limitations في بعض الدول تحط limitations على ال .. + +244 +00:16:40,080 --> 00:16:43,020 +ال foreign people و ال local people يعني مثلا إذا + +245 +00:16:43,020 --> 00:16:46,620 +بنحكي أجاري مثلا في السعودية مثلا ممكن ي .. في + +246 +00:16:46,620 --> 00:16:51,420 +limitations لل .. لل non-saudi peopleفال non-Saudi + +247 +00:16:51,420 --> 00:16:54,540 +people they have limitations, they cannot buy + +248 +00:16:54,540 --> 00:16:58,660 +these securities, unlimited securities، فيلهم عدد + +249 +00:16:58,660 --> 00:17:03,480 +محدد من ال securities، if you talk other areas for + +250 +00:17:03,480 --> 00:17:06,020 +instance if you talk about Kuwait and other + +251 +00:17:06,020 --> 00:17:09,580 +countries they .. they apply similar regulations + +252 +00:17:09,580 --> 00:17:14,790 +as in the Saudistock markets okay في بعض الناس لأ + +253 +00:17:14,790 --> 00:17:18,170 +it is open يعني مفتوحة و أي واحد بيشتري سواء + +254 +00:17:18,170 --> 00:17:21,310 +international people or local people they can buy + +255 +00:17:21,310 --> 00:17:23,650 +and sell the securities يعني بيقدروا يشتريوا و + +256 +00:17:23,650 --> 00:17:28,750 +يبيعوا ال securities private placements private + +257 +00:17:28,750 --> 00:17:34,410 +placements this is this private placements is + +258 +00:17:34,410 --> 00:17:39,170 +issued for a particular peopleparticular wealthy + +259 +00:17:39,170 --> 00:17:44,370 +people or a particular wealthy institution هاي ال + +260 +00:17:44,370 --> 00:17:48,450 +private placements ورقة مالية ممكن تكون سند هاي بس + +261 +00:17:48,450 --> 00:17:50,590 +مش واضحة شوية بالكتاب خلينا نوضح لكم بيها بس + +262 +00:17:50,590 --> 00:17:53,330 +بالكتاب المحتوط اللي هو private placements ال + +263 +00:17:53,330 --> 00:17:57,130 +private placement لل bonds بس ممكن نعمل احنا + +264 +00:17:57,130 --> 00:18:01,510 +private placement لل stocks كمان okay فإيش معنى + +265 +00:18:01,510 --> 00:18:03,550 +private placements private placement اللي احنا + +266 +00:18:03,550 --> 00:18:08,040 +نطرح سند او نطرح سهمفقط لأشخاص معينين في البلد + +267 +00:18:08,040 --> 00:18:11,040 +they have a good reputation they have a good + +268 +00:18:11,040 --> 00:18:14,780 +prestige they have a good wealth and so on يعني + +269 +00:18:14,780 --> 00:18:21,760 +مثلا عندنا عائلة معينة مثلا في لبنان okay يتم + +270 +00:18:21,760 --> 00:18:25,300 +إصدار أسهم فقط لهذه العائلة because of the + +271 +00:18:25,300 --> 00:18:28,180 +prestigious of the social position of this family + +272 +00:18:28,180 --> 00:18:34,300 +and this issue is is limited to this familyو هذا + +273 +00:18:34,300 --> 00:18:37,920 +الإصدار فقط لهذه العائلة أو لبعض الناس الموجودين + +274 +00:18:37,920 --> 00:18:41,920 +في هذه العائلة كمان ممكن يتم إصدار لشركة معينة + +275 +00:18:41,920 --> 00:18:46,560 +يعني انه انا .. انا شركة بدكو تروح تصدر أسهم فقط + +276 +00:18:46,560 --> 00:18:50,460 +اشتريها بنك فلسطين فبسموه private placement why .. + +277 +00:18:50,460 --> 00:18:52,600 +why companies they do this because private + +278 +00:18:52,600 --> 00:18:57,620 +placement is cheaper thanyes so you don't need to + +279 +00:18:57,620 --> 00:19:00,600 +pay a commission or high commission to the + +280 +00:19:00,600 --> 00:19:04,100 +investment bank يعني مابالذناش ندفع كتير + +281 +00:19:04,100 --> 00:19:06,860 +commission لل investment bank so some companies + +282 +00:19:06,860 --> 00:19:10,340 +they prefer to do private placement rather to do + +283 +00:19:10,340 --> 00:19:12,860 +likethe initial public offerings or public + +284 +00:19:12,860 --> 00:19:16,000 +offerings العمولة أقل this is the first thing the + +285 +00:19:16,000 --> 00:19:19,720 +second thing some companies they want to secure a + +286 +00:19:19,720 --> 00:19:22,760 +particular people as a member in their + +287 +00:19:22,760 --> 00:19:26,720 +organization بعض الشركات بفضله أشخاص معينين يكونوا + +288 +00:19:26,720 --> 00:19:29,880 +عندهم في الشركة so they they do private placement + +289 +00:19:29,880 --> 00:19:34,600 +for them these private placement stocks have هذه + +290 +00:19:34,600 --> 00:19:39,460 +الإصدارات الخاصةthe securities of private + +291 +00:19:39,460 --> 00:19:41,840 +placement are not listed in the financial markets + +292 +00:19:41,840 --> 00:19:44,960 +ممنوع يتم تدوّلها في السوق الماني because this is + +293 +00:19:44,960 --> 00:19:47,980 +just for a particular people يعني بعد ما يتم + +294 +00:19:47,980 --> 00:19:51,280 +الإصدار حتى بالسوق الأولي هذه مابتروحش على السوق + +295 +00:19:51,280 --> 00:19:54,760 +الثانوي وخلاص بتظلها limited يعني هدول الناس ممنوع + +296 +00:19:54,760 --> 00:19:58,620 +يبيعوا ممنوع يشتريوا في هذه الأسهم خلاص بتظلها + +297 +00:19:58,620 --> 00:20:01,360 +ملكية اللي هم هدول الناس + +298 +00:20:05,850 --> 00:20:09,010 +بنقش نحكي احتكار بس عشان نضمن ان هم ضالوا معنا + +299 +00:20:09,010 --> 00:20:15,830 +عشان نضمن ان الشركة هذه تبقى بها المستوى هنا okay + +300 +00:20:15,830 --> 00:20:21,250 +underwriting + +301 +00:20:21,250 --> 00:20:25,630 +قبل شوية كنا نسمع بال the rule of the investment + +302 +00:20:25,630 --> 00:20:30,700 +bank نرجع طلعه هانتطلعوا ال investment bank is + +303 +00:20:30,700 --> 00:20:33,840 +playing the intermediate role between the + +304 +00:20:33,840 --> 00:20:40,660 +companies or the firms and the investors so what + +305 +00:20:40,660 --> 00:20:43,860 +the investors or what is the investment bank + +306 +00:20:43,860 --> 00:20:47,420 +doing؟ the first thing is the underwriting + +307 +00:20:47,420 --> 00:20:53,720 +التغطية، أه بيسموها التغطية الإصدار the investment + +308 +00:20:53,720 --> 00:20:58,870 +bank has two main underwriting systemin your + +309 +00:20:58,870 --> 00:21:02,630 +textbook it is just only one يعني في ال textbook + +310 +00:21:02,630 --> 00:21:05,050 +تبعكم فيه نقطة واحد من الإصدارات اللي بيعملها + +311 +00:21:05,050 --> 00:21:08,230 +investment bank if in other advanced books there + +312 +00:21:08,230 --> 00:21:11,850 +are at least two في بعض الكتب المتقدمة شوية بال + +313 +00:21:11,850 --> 00:21:14,650 +investment في عندنا نوعين من دور ال investment + +314 +00:21:14,650 --> 00:21:17,350 +bank the first one is the underwriting investment + +315 +00:21:17,350 --> 00:21:19,610 +bank helps the firms to issue and market new + +316 +00:21:19,610 --> 00:21:22,790 +securities يعني بتساعدهم هدول الناس على إنهم + +317 +00:21:22,790 --> 00:21:25,950 +يعملوا إصدارات و يسوقولهم إيهاwhich known the + +318 +00:21:25,950 --> 00:21:31,550 +general or the well-known type of underwriting is + +319 +00:21:31,550 --> 00:21:37,670 +the firm commitments firm commitments it means the + +320 +00:21:37,670 --> 00:21:44,530 +investment bank sell the securities on behalf of + +321 +00:21:44,530 --> 00:21:49,450 +the companies full commitments full commitments + +322 +00:21:49,450 --> 00:21:53,230 +يعني هم بروحوا ببيعوا الإصدار بالكاملبالنيابة عن + +323 +00:21:53,230 --> 00:22:00,230 +اللي هو الشركة المصدرة للأسهم طبعا هاي ال + +324 +00:22:00,230 --> 00:22:04,310 +underwriting في شغل اسمه prospectus prospectus it + +325 +00:22:04,310 --> 00:22:13,350 +means is the guidelines of .. of the issue of .. + +326 +00:22:13,350 --> 00:22:15,770 +or the underwriting is the guidelines of the + +327 +00:22:15,770 --> 00:22:22,180 +underwriting هي عبارة عن دليل للإصدارهي إيش بتشمل؟ + +328 +00:22:22,180 --> 00:22:27,080 +بتشمل ال .. بتشمل اسم الشركة مثلاال objective + +329 +00:22:27,080 --> 00:22:31,780 +الأهداف تبع الشركة ال strategic tools ال vision ال + +330 +00:22:31,780 --> 00:22:36,780 +values ال aims the name of trustees أشخاص الناس + +331 +00:22:36,780 --> 00:22:41,940 +المؤسسين ال ال areas اللي بنعملوا فيها investment + +332 +00:22:41,940 --> 00:22:45,940 +الأماكن اللي بيعملوا فيها استثمار طريقة الإصدار + +333 +00:22:45,940 --> 00:22:49,500 +عدد الأسهم رأس المال المصرح بيه يعني details about + +334 +00:22:49,500 --> 00:22:53,260 +the the companies and details about theissue or + +335 +00:22:53,260 --> 00:22:56,960 +the underwriting يعني شغلات عامة الشركة وشغلات + +336 +00:22:56,960 --> 00:23:00,840 +بتخص الإصدار نفسه يعني أكمل سهل بدهم يصدروا؟ مين + +337 +00:23:00,840 --> 00:23:03,060 +بروك الاستثمار اللي هتروح تعملهم تسبيخ لهذه + +338 +00:23:03,060 --> 00:23:08,120 +الأسهم؟ إلى آخرينwhich includes prospectus as you + +339 +00:23:08,120 --> 00:23:10,960 +say describe the issue and prospectus of the + +340 +00:23:10,960 --> 00:23:16,360 +company تعمل شغل تاني الشغلة شو الشركة بتشتغل + +341 +00:23:16,360 --> 00:23:19,540 +أهدافها، استراتيجياتها، ال values تبعتها، مين + +342 +00:23:19,540 --> 00:23:22,080 +المؤسسين تبعونها، إيش ال vision تبعوها، إيه + +343 +00:23:22,080 --> 00:23:25,220 +الأخرين اللي حكيته وشغلة تانية بتخص الإصدار نفسه، + +344 +00:23:25,220 --> 00:23:29,620 +أكم ساهم بدون مين بنوك الاستثمار و هكذا prospectus + +345 +00:23:29,620 --> 00:23:33,800 +includes the red herring لو أنتوا روحتوا على ال .. + +346 +00:23:34,850 --> 00:23:37,230 +عال dictionary اللي كتبته red herring عارفيني شو + +347 +00:23:37,230 --> 00:23:40,950 +معناها red herring؟ red herring معناها ال .. زي ال + +348 +00:23:40,950 --> 00:23:45,010 +.. اه؟ ال ranch الحمراء اللي ايش؟ ال ranch الحمراء + +349 +00:23:45,010 --> 00:23:48,790 +اه اللي هي السمكة الحمراء او بيسموه بتعرفوا ال .. + +350 +00:23:48,790 --> 00:23:53,790 +سمك ال .. الهمور الهمور او سمك اللقس يعني بس اللون + +351 +00:23:53,790 --> 00:23:57,450 +أحمر هذا هذا اسمه ال red herring طبعا إيش موضوع؟ + +352 +00:23:57,450 --> 00:24:04,180 +ليش دخل هنا؟ و هو؟بنك Red herring هذا مصطلح قديم + +353 +00:24:04,180 --> 00:24:10,460 +بال financial markets it means the + +354 +00:24:10,460 --> 00:24:14,340 +prospectus is stamped in red يعني ال prospectus + +355 +00:24:14,340 --> 00:24:18,620 +الدليل لسه محطوط عليه ختم بالأحمر which means the + +356 +00:24:18,620 --> 00:24:24,920 +company should meet the regulations of the of the + +357 +00:24:24,920 --> 00:24:28,840 +stock exchange commission طبعا في stock exchange + +358 +00:24:28,840 --> 00:24:33,520 +commissionاللي هو ال stock exchange I think + +359 +00:24:33,520 --> 00:24:37,540 +commission okay stock exchange commission لأ اللي + +360 +00:24:37,540 --> 00:24:42,620 +هو لجنة تسويق الإصدار أو لجنة السوق المالي لأ هيئة + +361 +00:24:42,620 --> 00:24:45,160 +الأوراق المالية اسمها هيئة الأوراق المالية يعني + +362 +00:24:45,160 --> 00:24:48,820 +موجودة هذه في في سوق فلسطين الأوراق المالية يعني + +363 +00:24:48,820 --> 00:24:53,220 +الهيئة اللي بتنظم الإصدارات وهي بتكون غالبا هيئة + +364 +00:24:53,220 --> 00:24:58,000 +حكوميةإذا ما كانتش حكومية بتكون هي مرتبطة بالحكومة + +365 +00:24:58,000 --> 00:25:01,260 +بشكل غير مباشر لازم هم يوافقوا على إيش، يوافقوا + +366 +00:25:01,260 --> 00:25:03,480 +على الإصدار قبل ما يحكوا مع ال investment bank + +367 +00:25:03,480 --> 00:25:08,460 +فهذا ال process بيسموها red herring يعني is a + +368 +00:25:08,460 --> 00:25:11,580 +preliminary of prospectus يعني هي عبارة عن + +369 +00:25:11,580 --> 00:25:16,240 +prospectus لكن fast draftيعني ايش first draft؟ + +370 +00:25:16,240 --> 00:25:20,620 +يعني نسخة أولى، الواحد لما بيعمل يعني بيعمل واجب + +371 +00:25:20,620 --> 00:25:22,600 +بيبقى من النسخة الأولى، يعني لسه مش ال final draft + +372 +00:25:22,600 --> 00:25:26,960 +فبيعمل نسخة الأولى ال subject to some exchange وهي + +373 +00:25:26,960 --> 00:25:31,220 +ممكن يتم التغيير فيها لأنه هي مرتبطة بال + +374 +00:25:31,220 --> 00:25:35,020 +regulations و ال instructions اللي بتتطبق من ال + +375 +00:25:35,020 --> 00:25:39,910 +SEC اللي هو security exchange commissionفبعد ما هم + +376 +00:25:39,910 --> 00:25:44,690 +يقرروا يوافقوا على كل المتطلبات ويقولوا إن الشركة + +377 +00:25:44,690 --> 00:25:51,010 +فعلا يعني طبقت كل المعايير فبيصدروا ال final + +378 +00:25:51,010 --> 00:25:57,710 +prospectus يعني أول إشي بيردوا ال red herring ال + +379 +00:25:57,710 --> 00:26:00,650 +red herring هذه بتكون لسه first draft لل + +380 +00:26:00,650 --> 00:26:04,450 +prospectus and subject to change يعني مثلا أعطيكم + +381 +00:26:04,450 --> 00:26:07,870 +مثال بسيط لما بيبعتوا ال prospectus اللي هو الدليل + +382 +00:26:09,240 --> 00:26:13,080 +أول مرة بيسموه red herring بيكون مثلا اسم شخص مش + +383 +00:26:13,080 --> 00:26:17,120 +عاجبهم الحكومة أوه فبيحكيولهم انه هذا الشخص ما + +384 +00:26:17,120 --> 00:26:20,780 +بيبناش إياكم في هالشركة طب عامين اللي بيحكيلهم + +385 +00:26:20,780 --> 00:26:23,560 +الكلام هذا هيئة الأوراق المالية لأنه because this + +386 +00:26:23,560 --> 00:26:26,300 +is a public company هذه شركة مساهمة عامة so + +387 +00:26:26,300 --> 00:26:28,940 +sometimes the government intervene in the trustees + +388 +00:26:28,940 --> 00:26:37,200 +بتدخلوا في ال trustees ممكن رأس المال يعني + +389 +00:26:37,200 --> 00:26:43,310 +مثلاأكتر من المطلوب فبالتالي ممكن يتدخلوا في تخفيض + +390 +00:26:43,310 --> 00:26:47,450 +رأس المال ممكن يحكي مثلا some objectives they have + +391 +00:26:47,450 --> 00:26:50,830 +a vague objective يعني أهداف غير واضحة فممكن + +392 +00:26:50,830 --> 00:26:54,850 +يتدخلوا في الأهداف الواضحة كل هذا الأمور بدخل في + +393 +00:26:54,850 --> 00:26:57,970 +ال red herring بعد ما يعملوا يرتبوا أمور الشركة + +394 +00:26:57,970 --> 00:27:01,310 +ويتم الموافقة they issue the final prospectus + +395 +00:27:01,310 --> 00:27:08,620 +بصدروا ال final prospectus كيف الاتفاق معال .. ال + +396 +00:27:08,620 --> 00:27:13,120 +investment bank كيف الشركة بتدفق الشركة هاي مثلا + +397 +00:27:13,120 --> 00:27:16,020 +Badico و لا Battel و لا اي شركة مثلا بتدفق مع ال + +398 +00:27:16,020 --> 00:27:19,560 +investment bank عادة زي ما انتوا شايفين هاي الشركة + +399 +00:27:19,560 --> 00:27:23,220 +اللي بيبدأ تصدر الإصدار بيسموه issuing فعلا لازم + +400 +00:27:23,220 --> 00:27:27,400 +يكون في واحد اسمه lead underwriter يعني اللي هو + +401 +00:27:27,400 --> 00:27:30,840 +اللي بيقود الإصدار لازم يعني إذا كان investment + +402 +00:27:30,840 --> 00:27:35,670 +bank بتبقى بس هانا ال chartلو مثلا عندنا احنا شركة + +403 +00:27:35,670 --> 00:27:38,470 +كبيرة مثلا زي IBM و لا شركة General Motors و لا + +404 +00:27:38,470 --> 00:27:42,370 +شركة مثلا جديدة بتتنتشق و .. و الرأس المال سبعها + +405 +00:27:42,370 --> 00:27:45,830 +مثلا مليارات الدولارات فبالتالي ممكن ال investment + +406 +00:27:45,830 --> 00:27:49,250 +bank لوحده one investment bank cannot cover this + +407 +00:27:49,250 --> 00:27:53,030 +process مقدرش يغطي كل هذا ال process so it is + +408 +00:27:53,030 --> 00:27:56,070 +managed by different investment banks فممكن اكتر + +409 +00:27:56,070 --> 00:27:59,950 +من بنك استثمار يدخل في هذا ال process فعشان اكتر + +410 +00:27:59,950 --> 00:28:02,050 +يعني لو كان عندنا احنا five investment banks لو + +411 +00:28:02,050 --> 00:28:06,960 +كان عندنا خمسةلازم يكون فيه leader لازم يكون في + +412 +00:28:06,960 --> 00:28:10,740 +واحد leading and coordinating the .. the + +413 +00:28:10,740 --> 00:28:15,660 +underwriting واحد يقود وينسق ال underwriting فهم + +414 +00:28:15,660 --> 00:28:18,540 +بختاروا زي ما انتوا موجودين هنا هاي عندنا ال + +415 +00:28:18,540 --> 00:28:22,260 +leader فعلا اللي هو lead underwriter اللي هو ال .. + +416 +00:28:22,260 --> 00:28:25,680 +البنك الاستثمار المسئول الأول و الأخير عن إصدار + +417 +00:28:25,680 --> 00:28:28,500 +طبعا في زي ما انتوا شايفين في عندنا كذا bank يعني + +418 +00:28:28,500 --> 00:28:32,670 +هنا ايه؟ Bank A, Bank B, Bank C, Bank Dهدول هما + +419 +00:28:32,670 --> 00:28:35,870 +بيكونوا دخلين في عملية الإصدار، بعدين اللي هو + +420 +00:28:35,870 --> 00:28:40,230 +بروحوا لل private investors أو ل public investors + +421 +00:28:40,230 --> 00:28:45,290 +اللي هم المستثمرين اللي بدهم يشتريوا الإصدار okay + +422 +00:28:47,950 --> 00:28:50,410 +ال investment banking طبعا فهمنا احنا ال red + +423 +00:28:50,410 --> 00:28:53,810 +herring و ال prospectus نكمل برضه بال .. بال .. + +424 +00:28:53,810 --> 00:28:55,910 +بال investment bank .. banking و حكينا ال firm + +425 +00:28:55,910 --> 00:29:01,450 +commitment ال firm commitment حكيتها قبل شوية انه + +426 +00:29:01,450 --> 00:29:08,410 +تغطية كاملة بتعهد البنك الاستثمار بشراء او بتسويق + +427 +00:29:08,410 --> 00:29:13,290 +الإصدار لل publicو حكيت إنه في شغلة .. شغلة تانية + +428 +00:29:13,290 --> 00:29:16,610 +أو نوع تاني مش مطلوب منكم في هذا المستوى ممكن فقط + +429 +00:29:16,610 --> 00:29:19,570 +يكون دور البنك الاستثمار هو بيسموها partial + +430 +00:29:19,570 --> 00:29:23,550 +coverage اللي هو التغطية الجزئية يعني يروح فقط هو + +431 +00:29:23,550 --> 00:29:27,810 +مهمته بس يروح يبيع مش مهمته تغطية كاملة و بعد هيك + +432 +00:29:27,810 --> 00:29:34,250 +إذا مابعش فممكن ي .. ي .. يتم مثلا إجراءات أخرى + +433 +00:29:34,250 --> 00:29:37,410 +بالاتفاق مع بنك الاستثمار طيب فى هى ال commitment؟ + +434 +00:29:37,660 --> 00:29:40,340 +investment bank بيشير ال securities بنك الاستثمار + +435 +00:29:40,340 --> 00:29:42,580 +بيشتري ال securities from the issuing company + +436 +00:29:42,580 --> 00:29:45,440 +بيشتري من هذه الشركة زي ما انتوا شايفينه على ال + +437 +00:29:45,440 --> 00:29:48,700 +charts and then resell them to the public يعني + +438 +00:29:48,700 --> 00:29:53,700 +أولا بروح بنك الاستثمار بيشتري الإصدار كله يعني لو + +439 +00:29:53,700 --> 00:29:58,120 +مثلا شركة جديدة عندها مثلا عشرين مليون دولار بدهم + +440 +00:29:58,120 --> 00:30:04,100 +يصدروهم فبروح بنك الاستثمار بيشتريهم كلهمو بيروحوا + +441 +00:30:04,100 --> 00:30:09,480 +ببيعهم ل ال .. ل ال investors او لل public فهي + +442 +00:30:09,480 --> 00:30:13,600 +طريقة .. في طرق تانية طبعا مش مطلوبة منكم لأن فيها + +443 +00:30:13,600 --> 00:30:22,260 +تفاصيل اكتر من ال .. اه تفضل يا عفاف وينها؟ الاش؟ + +444 +00:30:22,260 --> 00:30:29,100 +تغطية الاسدارة الاسدارة يعني الأسهم المصدرة او + +445 +00:30:29,100 --> 00:30:33,020 +الأوراق المالية المصدرةطبعا بتعهد أول إيش بشتريها + +446 +00:30:33,020 --> 00:30:41,980 +و بعدين بروح ببيعها طبعا بناخد بالناهان يا بنات أن + +447 +00:30:41,980 --> 00:30:48,000 +ال IBO is good for investment هو كتير كويس + +448 +00:30:48,000 --> 00:30:52,980 +للاستثمار حسب الحالة اللي بتصير عن ال IBO لأنه + +449 +00:30:52,980 --> 00:31:01,980 +عادة ال investment bankas .. as the .. they manage + +450 +00:31:01,980 --> 00:31:07,500 +the .. the underwriting they issue .. they .. they + +451 +00:31:07,500 --> 00:31:11,040 +issue the securities below the predicted price + +452 +00:31:11,040 --> 00:31:16,140 +يعني إذا كان السعر السهم في السوق مثلا عشرين دولار + +453 +00:31:16,140 --> 00:31:20,300 +فهم بيحاولوا ينزلوا السعر مثلا لخمساش to encourage + +454 +00:31:20,300 --> 00:31:23,700 +.. to encourage investors to buy the .. the + +455 +00:31:23,700 --> 00:31:28,450 +underwriting عشان يشجعوهملكن هذا لا يعني ان + +456 +00:31:28,450 --> 00:31:32,330 +الشركات كل شركات الاستثمار هبتعمل لك لأ some + +457 +00:31:32,330 --> 00:31:36,150 +companies they do this طيب بال investment banking + +458 +00:31:36,150 --> 00:31:38,810 +process we have something is known shelf + +459 +00:31:38,810 --> 00:31:44,210 +registration okay shelf يعني rough التسجيل طبعا هي + +460 +00:31:44,210 --> 00:31:51,530 +التسجيل التسجيل الشركات انتبه + +461 +00:31:51,530 --> 00:31:55,370 +انا حكيت انا ال SECاللي هو security exchange + +462 +00:31:55,370 --> 00:32:00,590 +commission في عندها role رقم 415 وهذا ال role فيه + +463 +00:32:00,590 --> 00:32:04,050 +role .. role مشابه له او مشابه انه في سوق فلسطين + +464 +00:32:04,050 --> 00:32:07,330 +أوراق المالية يعني تقريبا نفس التعليمات والتوجيهات + +465 +00:32:07,330 --> 00:32:11,810 +هذا shelf registration اشمنه allows firm to + +466 +00:32:11,810 --> 00:32:14,930 +register securities and gradually sell them to the + +467 +00:32:14,930 --> 00:32:20,550 +public for two years مسموح للشركة انه + +468 +00:32:23,640 --> 00:32:28,200 +يتم تسجيل ال securities في هيئة الأوراق المالية و + +469 +00:32:28,200 --> 00:32:32,360 +خلال فترة سنتين لازم هذه الشركة تنتقل لل primary + +470 +00:32:32,360 --> 00:32:37,660 +markets لأ معهم two years يعني بيبدوا يبيعوا ال .. + +471 +00:32:37,660 --> 00:32:40,120 +ال .. الأسهم لل .. أو ال securities لل investors + +472 +00:32:40,120 --> 00:32:45,600 +within two years خلال سنتين the company or the + +473 +00:32:45,600 --> 00:32:49,810 +securities should go to the secondary marketsthey + +474 +00:32:49,810 --> 00:32:53,290 +have to apply the regulations and instructions of + +475 +00:32:53,290 --> 00:32:57,450 +the SEC لازم يطبقوا ال .. ال regulations what + +476 +00:32:57,450 --> 00:32:59,610 +these regulations شو هاد ال regulations for + +477 +00:32:59,610 --> 00:33:03,170 +instance they have to issue to a profitable income + +478 +00:33:03,170 --> 00:33:07,550 +statement مثلا واحدة من التعليمات لازم يصدروا + +479 +00:33:07,550 --> 00:33:11,650 +سنتين أرباح تحقيق أرباح أو بيسموها income + +480 +00:33:11,650 --> 00:33:15,850 +statement لازم يصدروا سنتين فيها أرباحتمام؟ لازم + +481 +00:33:15,850 --> 00:33:19,230 +يكون مثلا ال .. ال liquidity ratios ال activity + +482 +00:33:19,230 --> 00:33:22,630 +ratios ال .. ال leverage ratios and is acceptable + +483 +00:33:22,630 --> 00:33:27,030 +يعني التحليل المالي تبع الشركة تحليل وضع جيد ال + +484 +00:33:27,030 --> 00:33:30,170 +market شركتها بقتها مقبولة بعد هيك إذا صار في + +485 +00:33:30,170 --> 00:33:35,030 +الشروط هذه ممكن تروح على ال secondary markets فهي + +486 +00:33:35,030 --> 00:33:39,110 +.. هي .. هي الخطوة بيسموها shelf registration يعني + +487 +00:33:39,110 --> 00:33:42,830 +بروح بسجلهفي ال .. في هيئة الأوراق البالية and + +488 +00:33:42,830 --> 00:33:45,050 +they are waiting to be in the secondary market + +489 +00:33:45,050 --> 00:33:48,690 +يعني هم they are in the queue يعني بيظلهم سنتين مش + +490 +00:33:48,690 --> 00:33:52,610 +دخلين في السوق المالي العادي بيظلهم لمدة سنتين برا + +491 +00:33:52,610 --> 00:33:57,730 +السوق لكن مسجلين هم مافيه حتى يكتمل الشروط و تروح + +492 +00:33:57,730 --> 00:34:02,990 +على السوق المالي الثانوي within two years in some + +493 +00:34:02,990 --> 00:34:07,430 +countries they ask for three years في بعض الدول + +494 +00:34:07,430 --> 00:34:09,630 +ممكن .. بعد تلت سنوات + +495 +00:34:15,240 --> 00:34:21,000 +زاية بقى؟ زاية من الأولى .. زاية من الأولى بعد سنة + +496 +00:34:21,000 --> 00:34:23,540 +بيشوفون علم علشان دي و بعدين بروحوا على ال + +497 +00:34:23,540 --> 00:34:24,540 +secondary market بروحوا على ال secondary market + +498 +00:34:24,540 --> 00:34:28,160 +فهي ال .. ال .. ال .. ال queue عارفة إيش معنى + +499 +00:34:28,160 --> 00:34:31,340 +queue، queue يعني بالانتظار، بكونوا هبقى بالانتظار + +500 +00:34:31,340 --> 00:34:34,960 +لازم إنه يكون عندهم وضع مالي كويس و لازم يكون + +501 +00:34:34,960 --> 00:34:41,100 +عندهم تقارير مالية جيدة و بعد هيك بروحوا على ال + +502 +00:34:41,100 --> 00:34:41,940 +secondary markets + +503 +00:34:46,730 --> 00:34:50,430 +بال .. اه بي .. بيصير .. طبعا بيفرق كتير لإنه + +504 +00:34:50,430 --> 00:34:54,050 +ممنوع يصير trade ممنوع يصير التجارة في أسهمها + +505 +00:34:54,050 --> 00:34:59,090 +بيصير + +506 +00:34:59,090 --> 00:35:01,710 +لما يقع .. اه بالظبط بيصير .. بيصير أعمالية بيع + +507 +00:35:01,710 --> 00:35:05,510 +داخلية بين المستثمرين، تمام؟ لكن مش بالطريقة اللي + +508 +00:35:05,510 --> 00:35:10,030 +بيصير فيها ال secondary markets، تمام؟ + +509 +00:35:10,030 --> 00:35:15,150 +طيب طب ماعش الحل، احنا ب .. we just end هذا الحل + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/8zptgmDPa7g_postprocess.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/8zptgmDPa7g_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..cd7b3f6881046365219d7f23ce2d4cbe16b41f4c --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/8zptgmDPa7g_postprocess.srt @@ -0,0 +1,1364 @@ +1 +00:00:20,650 --> 00:00:23,650 +بسم الله الرحمن الرحيم المرة اللي فاتت كنا نحكي عن + +2 +00:00:23,650 --> 00:00:27,950 +ال .. ال margin بس لما كنا نحكي بال margin كنا + +3 +00:00:27,950 --> 00:00:33,050 +نبدأ بال buy نبدأ عملية شراء بس اليوم نحكي إذا كان + +4 +00:00:33,050 --> 00:00:40,450 +نبدأ margin بعملية بيع اه موبايل مين نبدأ عملية + +5 +00:00:40,450 --> 00:00:44,870 +بيع كيف يبتم عملية البيع احنا شرحنا لكم المرة اللي + +6 +00:00:44,870 --> 00:00:50,740 +فاتت ال short sale مظبوط ال short saleاحنا بنبدأ + +7 +00:00:50,740 --> 00:00:53,800 +المرة + +8 +00:00:53,800 --> 00:00:58,240 +ثالثة حكينا عن short sale short sale لأ حكينا + +9 +00:00:58,240 --> 00:01:03,760 +حكينا short sale ان احنا بنبدأ ب sale فاكرين لما + +10 +00:01:03,760 --> 00:01:10,580 +حكينا ان احنا نسلف mobile و بنبيعه حكينا عنه اللي + +11 +00:01:10,580 --> 00:01:14,440 +هو هذا اسمه short sale ال short sale ببدأ اذا احنا + +12 +00:01:14,440 --> 00:01:22,830 +كنا بنبدأ في عملية بيعنبدأ بيع كيف نبدأ بيع؟ نبدأ + +13 +00:01:22,830 --> 00:01:26,550 +بيع الهاتف تمام بعد ما ن .. we borrow the .. the + +14 +00:01:26,550 --> 00:01:30,450 +mobile or we borrow the stock نظبط احنا we + +15 +00:01:30,450 --> 00:01:36,690 +starting by borrowing the stock borrow stock or + +16 +00:01:36,690 --> 00:01:40,090 +mobile زي ما احنا اعطيناكم المرة الفاتة نبدأ بيع + +17 +00:01:40,090 --> 00:01:45,670 +الهاتف okayبعد ما ندهن موبايل يكون ال expectations + +18 +00:01:45,670 --> 00:01:50,530 +تبعتنا ال prices will go down الأسعار هتنخفض طبعا + +19 +00:01:50,530 --> 00:02:01,230 +لو احنا أخدنا مثلا شوفنا كيف بيصير لو كان احنا + +20 +00:02:01,230 --> 00:02:07,170 +عندنا هذا ال chart وهي + +21 +00:02:07,170 --> 00:02:12,730 +الأسعار هتتذبذب الأسعار ال pricesهذه ال prices + +22 +00:02:12,730 --> 00:02:16,490 +okay زي ما انتوا شايفين شوفوا السعر وين وصل اعلى + +23 +00:02:16,490 --> 00:02:24,190 +حد في المرحلة هذه مسموح ال broker يدين ال investor + +24 +00:02:24,190 --> 00:02:29,130 +لكن لو حكينا مثلا لو كانت الأسعار بهذه الطريقة هذه + +25 +00:02:32,190 --> 00:02:35,950 +هن احتمالات الانخفاض اكتر من احتمالات الارتفاع او + +26 +00:02:35,950 --> 00:02:39,410 +احتمالات الارتفاع اكتر من احتمالات الانخفاض فهن ال + +27 +00:02:39,410 --> 00:02:42,630 +.. ال broker مابيعطيش .. بيدينش ال .. ال investor + +28 +00:02:42,630 --> 00:02:48,570 +ال stocks فال short sale غالبا بيسير لما يكون ال + +29 +00:02:48,570 --> 00:02:52,570 +.. ال market up لما يكون ال market up فبيكون + +30 +00:02:52,570 --> 00:02:57,650 +احتمالات الانخفاض اكتر من احتمالات الارتفاع فلو + +31 +00:02:57,650 --> 00:03:04,200 +جينا احنا هن ال stockwe borrow stock from the + +32 +00:03:04,200 --> 00:03:07,500 +broker احنا ديالنا stock من ال broker دلوقت ما + +33 +00:03:07,500 --> 00:03:11,240 +ديالناش فلوس we borrow stocks for instance we + +34 +00:03:11,240 --> 00:03:16,160 +borrow one hundred stocks we sell them off احنا + +35 +00:03:16,160 --> 00:03:21,520 +يااش بيعناهم دلوقت احنا مااشترينا احنا we start + +36 +00:03:21,520 --> 00:03:26,200 +selling off the stock كان السعر على one hundred + +37 +00:03:28,350 --> 00:03:31,170 +بيعناها على one hundred فصار في جيبتنا كام؟ مية + +38 +00:03:31,170 --> 00:03:35,550 +دولار لو كان عندنا مية share فبصير عندنا مية في + +39 +00:03:35,550 --> 00:03:42,010 +مية كم؟ عشر تلاف دولار okay هلأ الأسعار starting + +40 +00:03:42,010 --> 00:03:48,710 +to go down till for instance sixty حتى وصلت ستين + +41 +00:03:48,710 --> 00:03:53,930 +طبعا عند المرحلة هذه ممكن احنا بنعمل اذا عملنا + +42 +00:03:53,930 --> 00:04:00,440 +sell هان ايش هنعمل هان؟ هنعمل buyليش نعمل buy؟ + +43 +00:04:00,440 --> 00:04:05,640 +عشان نرجع ال stocks لمن؟ لل .. لل broker فلما نعمل + +44 +00:04:05,640 --> 00:04:11,640 +buy ستين اللي هو ستين .. ستين سهم في .. ستين دولار + +45 +00:04:11,640 --> 00:04:16,620 +عفوا في مية سهم تطلع كام؟ ست الاف دولار لما نعمل + +46 +00:04:16,620 --> 00:04:21,000 +buy بيطلع من .. من جبتنا فلوس نشتري فكام رمحنا من + +47 +00:04:21,000 --> 00:04:26,720 +ورا هالشغل هاي؟ أربع تلاف دولارfour thousand + +48 +00:04:26,720 --> 00:04:34,820 +dollar okay لكن مثلا بعد أسبوع بعد أسبوع بعد أسبوع + +49 +00:04:34,820 --> 00:04:40,300 +الأسعار كانت متخفضة نازلة إذا في ال short sale ال + +50 +00:04:40,300 --> 00:04:45,640 +investors they prefer the prices to go down ال + +51 +00:04:45,640 --> 00:04:48,460 +investors لما بيكونوا عاملين short sale بفضلوا + +52 +00:04:48,460 --> 00:04:52,380 +الأسعار يتنخفض لأنه كل ما انخفضت الأسعار كل ما + +53 +00:04:52,380 --> 00:04:57,580 +بزيد الربح تبعهمو هذا سبب عمل ال financial crisis + +54 +00:04:57,580 --> 00:05:03,840 +عمل سبب مش .. مش هو السبب الرئيسي لكن one of the + +55 +00:05:03,840 --> 00:05:06,640 +.. the .. the important or the major problem in + +56 +00:05:06,640 --> 00:05:09,720 +the .. in the financial market crisis is the short + +57 +00:05:09,720 --> 00:05:12,940 +sale يعني هذا عمل برضه مشكلة في الأزمة المالية + +58 +00:05:12,940 --> 00:05:15,680 +يعني خلينا نحكي مثلا this group prefer the prices + +59 +00:05:15,680 --> 00:05:19,160 +to go down and this group prefer the prices to go + +60 +00:05:19,160 --> 00:05:22,900 +up يعني في صار في السوق ناس مصلحتهم السوق ينزل و + +61 +00:05:22,900 --> 00:05:27,700 +في ناس مصلحتهم السوق يطلعand if the .. if the + +62 +00:05:27,700 --> 00:05:30,860 +number of people prefer the prices to go down + +63 +00:05:30,860 --> 00:05:34,180 +exceed the number of people prefer the prices to + +64 +00:05:34,180 --> 00:05:37,700 +go up so the financial market will go down يعني + +65 +00:05:37,700 --> 00:05:40,920 +إذا كان عدد الناس اللي بفضله للسوق ينزل أكتر من + +66 +00:05:40,920 --> 00:05:43,740 +عدد الناس اللي بفضله السوق يطلع وبالتالي السوق + +67 +00:05:43,740 --> 00:05:49,040 +هينزل هذا بيعمل ال .. make the financial crisis + +68 +00:05:49,040 --> 00:05:53,280 +worse and worse يعني بعمق الأزمة المالية so the .. + +69 +00:05:53,280 --> 00:05:56,800 +the financial market committeeor the security + +70 +00:05:56,800 --> 00:06:00,340 +exchange commission stopped the short sales in + +71 +00:06:00,340 --> 00:06:07,060 +2009 and 2008 في ال 2008 و 2009 وقفوا ال short + +72 +00:06:07,060 --> 00:06:12,180 +sale لأنه صار في ناس مصطحتهم السوق ينزل ومصطحة ال + +73 +00:06:12,180 --> 00:06:16,240 +financial market commission انه بدهم السوق يطلع ف + +74 +00:06:16,240 --> 00:06:19,960 +they stop people who prefer that the financial + +75 +00:06:19,960 --> 00:06:24,800 +market is going down فهذه مش بسيطة ال short sale + +76 +00:06:26,390 --> 00:06:30,610 +فهي الربح طيب المشكلة وين؟ if the prices goes up + +77 +00:06:30,610 --> 00:06:38,090 +إذا الأسعار طلعت okay for instance let's say if + +78 +00:06:38,090 --> 00:06:42,970 +the prices goes to 120 so + +79 +00:06:42,970 --> 00:06:47,710 +he .. he want to buy the .. the stocks at 120 so + +80 +00:06:47,710 --> 00:06:54,110 +we have 120 times 100 so he has to pay 1000 or + +81 +00:06:54,110 --> 00:07:01,160 +12000Okay twelve thousands minus and ten thousand + +82 +00:07:01,160 --> 00:07:06,380 +plus so he or she lost minus two thousands بيخسر + +83 +00:07:06,380 --> 00:07:14,680 +الفين consider that انتبهوا لل short sale ال short + +84 +00:07:14,680 --> 00:07:20,500 +sale at the beginning he paid nothing في البداية + +85 +00:07:20,500 --> 00:07:26,120 +هو مادفعش اشيand when he lost 2000 he lost from + +86 +00:07:26,120 --> 00:07:29,680 +the broker account هو خسر من .. من مصال ال broker + +87 +00:07:29,680 --> 00:07:34,400 +because of this situation بهذا السبب the broker + +88 +00:07:34,400 --> 00:07:39,260 +asking the investor to put collateral ال .. ال + +89 +00:07:39,260 --> 00:07:42,860 +broker اللي هو ال .. ال .. السمسار او ال dealer + +90 +00:07:42,860 --> 00:07:47,600 +بطلب من ال investor يحط collateral collateral يعني + +91 +00:07:47,600 --> 00:07:54,440 +ضماناتOkay? So if he lost his money, it means he + +92 +00:07:54,440 --> 00:07:57,760 +lost his collateral. إذا بيخسر الفلوس، بده يخسر من + +93 +00:07:57,760 --> 00:08:00,100 +ال collateral تبعته، من الدمونات، not from the + +94 +00:08:00,100 --> 00:08:04,160 +broker fund، + +95 +00:08:04,160 --> 00:08:07,400 +ليش من الفلوس ال broker؟ يعني إحنا خلينا نرجع لل + +96 +00:08:07,400 --> 00:08:11,580 +short sale. لما صار في .. عندنا sale، ال investors + +97 +00:08:11,580 --> 00:08:16,230 +ما دفعش إشيمباشر راح ودّين ال .. ال stocks دين + +98 +00:08:16,230 --> 00:08:21,930 +وراح باعهم وعمل الصفقة تبعتهم he paid nothing طب + +99 +00:08:21,930 --> 00:08:26,310 +هذا ممكن يعمل مشاكل في الأسواق المالية okay فعشان + +100 +00:08:26,310 --> 00:08:31,610 +هيك ال .. ال broker asking the .. the investors to + +101 +00:08:31,610 --> 00:08:34,370 +put collateral ممكن ال collateral تكون deposit + +102 +00:08:34,370 --> 00:08:40,530 +وديعة ممكن تكون treasury bills bonds anythingOkay + +103 +00:08:40,530 --> 00:08:45,050 +and this collateral is considered as a margin عشان + +104 +00:08:45,050 --> 00:08:48,230 +نرجع لما هو فكرة ال margin ال collateral تعتبر ايش + +105 +00:08:48,230 --> 00:08:54,970 +margin يعني هامش okay بناء عليه بي .. بيعمل ال + +106 +00:08:54,970 --> 00:09:00,870 +investor trades okay فنرجع لل short sale الهدف من + +107 +00:09:00,870 --> 00:09:05,370 +ال short sale زي ما انا حكيتلكمthe main objective + +108 +00:09:05,370 --> 00:09:09,310 +of the short sale to profit from a decline زي ما + +109 +00:09:09,310 --> 00:09:15,030 +تشايفين in the prices of stock or security يعني + +110 +00:09:15,030 --> 00:09:20,570 +الهدف أنه احنا نربح كل ما السوق نزل okay بعكس إذا + +111 +00:09:20,570 --> 00:09:26,620 +أنا بدأت buy احنا بنربح لما السوق يهاش يطلعOkay + +112 +00:09:26,620 --> 00:09:31,260 +لما أنا بعمل buy بشتري بربح لما السوق يطلع لما كنت + +113 +00:09:31,260 --> 00:09:38,260 +ببدأ في sell بربح لما السوق يبدأ ينزل mechanics + +114 +00:09:38,260 --> 00:09:42,420 +the mechanisms of doing this I explained this but + +115 +00:09:42,420 --> 00:09:47,160 +just to to give you more details the mechanisms of + +116 +00:09:47,160 --> 00:09:50,160 +doing this borrow stock through a dealer زي ما + +117 +00:09:50,160 --> 00:09:53,100 +حكينا في البداية from the buyer stock be careful + +118 +00:09:53,100 --> 00:09:57,840 +we are borrowing stockاحنا بنداين أيش؟ Stock and + +119 +00:09:57,840 --> 00:10:01,040 +when we pay back, we pay back Stock كمان لما + +120 +00:10:01,040 --> 00:10:06,780 +بنرجع، بنرجع أيش؟ بنرجع Stock the second sell it + +121 +00:10:06,780 --> 00:10:11,580 +and deposit proceeds and margin in accounts بنبيع + +122 +00:10:11,580 --> 00:10:16,720 +المبلغ، بنبيع ال security sell it اللي هو احنا + +123 +00:10:16,720 --> 00:10:23,970 +جابلاش احنا بيبناها بيبناها بعشر تلاف صح؟زائد + +124 +00:10:23,970 --> 00:10:29,170 +انتبهان and deposit في عندنا بنبيع وكمان في وديعة + +125 +00:10:29,170 --> 00:10:31,850 +لازم نحطها اللي هو اللي حكينا عنها اللي هو الضمانة + +126 +00:10:31,850 --> 00:10:36,330 +and deposit proceeds and margin in account كمان + +127 +00:10:36,330 --> 00:10:40,290 +بنودعهم و الضمانات في نفطر الضمانات كانت خمسين ألف + +128 +00:10:40,290 --> 00:10:44,610 +دولار فسعر كم في حساب ال .. مية و خمسين ألف دولار + +129 +00:10:44,610 --> 00:10:53,790 +خمسين ألف زائد .. عفوا نفطرت خمس تلاف دولارOkay + +130 +00:10:53,790 --> 00:10:56,310 +بيصير خمسة عشر أربع دولار عشان طبعا هي المبلغ اللي + +131 +00:10:56,310 --> 00:11:00,050 +بيطلب ال broker من ال Tesla لإيجاره قبل ما .. عشان + +132 +00:11:00,050 --> 00:11:03,010 +ليه السلسل؟ اه اللي هو الدولار .. لأ لأ هذا بيختلف + +133 +00:11:03,010 --> 00:11:07,290 +شوية احنا بنحكي عن short sale اه في ال .. في ال .. + +134 +00:11:07,290 --> 00:11:10,790 +في ال buying العادى بطلب منه زي ما انت حكيته بيطلب + +135 +00:11:10,790 --> 00:11:14,610 +منه فلوس يبدأ يشتغل فيهم بس في short sale لإن هو + +136 +00:11:14,610 --> 00:11:18,670 +مابدأش يشتري بيبدأ في بيع .. في بيع okay فهو بيدعي + +137 +00:11:18,670 --> 00:11:25,020 +يعني stocksفبطلب منه إنه يكون في عنده ضمانة اللي + +138 +00:11:25,020 --> 00:11:32,160 +هو وديعة مثلا أو أي إشي okay فبعد ما يبيع ال .. ال + +139 +00:11:32,160 --> 00:11:36,580 +stocks بوضعهم في حساب ال broker و بإضافة للضمانة + +140 +00:11:36,580 --> 00:11:39,640 +بصير عنده خمستاشر ألف اللي هو عشر تلاف ال stocks + +141 +00:11:39,640 --> 00:11:42,300 +اللي باعها و الخمس تلاف اللي هو الضمانة بتاعته + +142 +00:11:44,500 --> 00:11:47,660 +after a period of time بعد فترة معينة هم متفقين + +143 +00:11:47,660 --> 00:11:51,060 +أنه هم يتدينوا مثلا مبلغ لمدة أسبوع أو شهر أو + +144 +00:11:51,060 --> 00:11:55,520 +اللذي هو okay closing out the position بعد هذه + +145 +00:11:55,520 --> 00:11:59,600 +الفترة بيصير إغلاق لل position يعني مثلا إذا كان + +146 +00:11:59,600 --> 00:12:07,620 +بنخفض بربح وإذا كان برتفع بيخسر okay and after he + +147 +00:12:07,620 --> 00:12:10,000 +or she closed the position بعد ما هم يسكروا ال + +148 +00:12:10,000 --> 00:12:15,270 +position سبعتهمthe investor has to .. to retain + +149 +00:12:15,270 --> 00:12:21,130 +the stocks to the .. to the broker لازم ارجع ليش؟ + +150 +00:12:21,130 --> 00:12:29,750 +ال stocks لل broker واضحة طيب أسهم + +151 +00:12:29,750 --> 00:12:32,290 +بسهم مش فلوس دلوقت هذي يعني is a matter of + +152 +00:12:32,290 --> 00:12:36,340 +confusionSo be careful on your exam, try to answer + +153 +00:12:36,340 --> 00:12:39,300 +the questions at the end of this chapter, there is + +154 +00:12:39,300 --> 00:12:42,220 +at least you have three four questions about the + +155 +00:12:42,220 --> 00:12:45,980 +short cells موجود عندكم حوالي تلت أربع أسئلة على + +156 +00:12:45,980 --> 00:12:51,080 +هذا الموضوع خليني أاخد مثال المهم أنه درجة أسنان + +157 +00:12:51,080 --> 00:12:53,500 +أسفل كيف هتتعرف بسرعة و تتعرف بسرعة + +158 +00:12:57,820 --> 00:13:02,160 +كيف هتظهر ربح و الخسارة طيب هلأ خليني افكر هان هو + +159 +00:13:02,160 --> 00:13:06,060 +الدايا ليه تساهم صح؟ أخد الأسهم أخد الأسهم هلأ + +160 +00:13:06,060 --> 00:13:10,780 +الأسهم معاه فراح باع الأسهم على 100 دولار فكان في + +161 +00:13:10,780 --> 00:13:16,380 +.. في حسابه اه okay عشر تلاف نفترض عشر تلاف سبب + +162 +00:13:16,380 --> 00:13:21,250 +هلأ اذا if the price is going uphe will lose if + +163 +00:13:21,250 --> 00:13:25,950 +the prices go down make a profit ليش؟ لأن هو هذا + +164 +00:13:25,950 --> 00:13:30,190 +باعهم فدخل في ال pocket سبعة فلوس مصاري الف دولار + +165 +00:13:30,190 --> 00:13:33,850 +هلأ لما ينزل السعر بدو يشتريه عشان يرجع ال stocks + +166 +00:13:33,850 --> 00:13:37,990 +فنزل السعر لستين دولار فكدهاش بده يدفع عشان يشتري + +167 +00:13:37,990 --> 00:13:44,960 +الأسهم ستين دولار فبطلع من جيبته ستين دولارفربح + +168 +00:13:44,960 --> 00:13:48,020 +ستين اللي طلعوا اللي هو هنا المية دخلوا في ال .. + +169 +00:13:48,020 --> 00:13:51,800 +في الجيبة تبعته و ستين طلعوا فبطلع ربحان اربعين + +170 +00:13:51,800 --> 00:13:56,660 +دولار اربعين في مثلا في مية سهم بطلع ربحه اربع + +171 +00:13:56,660 --> 00:14:01,600 +تلاف سهم لو كان في deposit في حسابه بيقول اربع + +172 +00:14:01,600 --> 00:14:05,140 +تلاف زائد خمس تلاف بيصير عنده نسعة تلاف دولار في + +173 +00:14:05,140 --> 00:14:07,860 +حسابه okay هسيئ مثلا + +174 +00:14:11,630 --> 00:14:17,350 +Okay let's take a example هنا دعنا ناخد مثال مثال + +175 +00:14:17,350 --> 00:14:20,830 +آخر dot + +176 +00:14:20,830 --> 00:14:25,710 +bomb dot bomb يعني شركة اشترت بدى تعمل one + +177 +00:14:25,710 --> 00:14:32,590 +thousand sharesshort sale يعني هم بدهم اتدينوا ألف + +178 +00:14:32,590 --> 00:14:35,690 +سهم احنا كنا في مثالنا مية صح احنا هنا بناخد ألف + +179 +00:14:35,690 --> 00:14:40,610 +سهم اتدينوا ألف سهم okay fifty percent initial + +180 +00:14:40,610 --> 00:14:44,050 +margin ايش يعني هال initial margin fifty percent + +181 +00:14:44,050 --> 00:14:49,330 +هي ال collateral خمسين في المية عشان نعرف كام + +182 +00:14:49,330 --> 00:14:54,070 +خمسين في المية لها ال initial marginيعني ال + +183 +00:14:54,070 --> 00:14:56,270 +collateral اللي هو الدماء المطلوبة خمسين في المية + +184 +00:14:56,270 --> 00:14:59,910 +اللي هو ال deposit اللي تاوعي حكينا فيها 30% is + +185 +00:14:59,910 --> 00:15:04,030 +the maintenance margin ايش ال maintenance margin؟ + +186 +00:15:04,030 --> 00:15:08,750 +يلا اشرحتكوا يا مرة فاتت maintenance margin هامش + +187 +00:15:08,750 --> 00:15:13,330 +الصيانة طب ايش هذا .. ليش هامش الصيانة؟ ليش + +188 +00:15:13,330 --> 00:15:16,530 +بنعمله؟ ليش ال broker بيعمل هامش الصيانة؟ + +189 +00:15:19,160 --> 00:15:23,380 +أه لأنه إذا ال .. إذا ال investor بيضلوا يتاجر + +190 +00:15:23,380 --> 00:15:29,920 +فهيخسر فلوسه فهو زي ما حكنالكم أنه في ethics بال + +191 +00:15:29,920 --> 00:15:33,380 +financial markets انتبهوا لكلام اللي بحكيه في + +192 +00:15:33,380 --> 00:15:35,680 +ethics بال financial markets بال financial market + +193 +00:15:35,680 --> 00:15:40,160 +إذا شافوا واحد و خاصة in the .. in the high + +194 +00:15:40,160 --> 00:15:44,180 +regulated markets في ال high regulated marketsفي + +195 +00:15:44,180 --> 00:15:47,240 +يعني أسواق مالية فيها تعليمات قوية و خاصة بعد + +196 +00:15:47,240 --> 00:15:51,140 +الأزمة العالمية شو اللي بيصير؟ إذا شافوا investors + +197 +00:15:51,140 --> 00:15:54,820 +جايب معاه فلوس نفترض أنه جايب معاه مية ألف دولار + +198 +00:15:54,820 --> 00:16:01,160 +أو بدأ يعمل trades خسر الأول عشر تلاف بعدين خسر + +199 +00:16:01,160 --> 00:16:04,900 +العشر تلاف اللي بعديها so the dealer has to stop + +200 +00:16:04,900 --> 00:16:10,740 +him ال dealer لازم واقفه because if he continues + +201 +00:16:11,640 --> 00:16:16,580 +إذا ضلوا يكمل he will lose all of his money هيخسار + +202 +00:16:16,580 --> 00:16:20,700 +كل فلوسه so from ethical perspective from ethical + +203 +00:16:20,700 --> 00:16:25,760 +perspective the dealer ask him to stop because if + +204 +00:16:25,760 --> 00:16:30,540 +he continues he will lose his money okay and if he + +205 +00:16:30,540 --> 00:16:34,560 +didn't listen to the dealer the dealer will close + +206 +00:16:34,560 --> 00:16:38,600 +and asking him take your money and go to your mom + +207 +00:16:39,810 --> 00:16:43,050 +know how to trade and coming back روح روح و اتعلم + +208 +00:16:43,050 --> 00:16:46,730 +كيف تشتغل و بعدين ارجعلنا so this is ethical + +209 +00:16:46,730 --> 00:16:50,930 +things in the financial market so the idea here is + +210 +00:16:50,930 --> 00:16:56,430 +the financial market try to protect the investor + +211 +00:16:56,430 --> 00:17:05,180 +wealth okay and because of thisالعامل يطلب من + +212 +00:17:05,180 --> 00:17:08,640 +المستخدم أن يقوم باستخدام كولاترال في هذه الحالة + +213 +00:17:08,640 --> 00:17:16,080 +50% وهو المقارنة الأولى إذا كان المستخدم يستمر في + +214 +00:17:16,080 --> 00:17:20,680 +فقدر ماله في مقارنة التعامل سيفعل مقارنة التعامل + +215 +00:17:20,680 --> 00:17:23,720 +الشركة أو العامل يفعل مقارنة التعامل يطلب منه مال + +216 +00:17:23,720 --> 00:17:28,840 +اضافية إذا لم يسمع العامل يغلق الموقع + +217 +00:17:32,480 --> 00:17:37,280 +الـ 30% our question is هي what is the price at + +218 +00:17:37,280 --> 00:17:43,720 +which the .. the broker make the .. the + +219 +00:17:43,720 --> 00:17:47,560 +maintenance call تعتقدوا هيكون السعر أعلى من 100 + +220 +00:17:47,560 --> 00:17:52,760 +ولا أقل من 100؟ أشوف شطرتكم لما يعمل maintenance + +221 +00:17:52,760 --> 00:17:55,140 +.. maintenance call or maintenance margin ال + +222 +00:17:55,140 --> 00:17:58,860 +broker أعلى من 100 أعلى من 100؟ ليش أعلى من 100؟ + +223 +00:17:58,860 --> 00:18:03,180 +أهي لأن بعد المية بتبقى الخسارةلأن it is not worth + +224 +00:18:03,180 --> 00:18:06,320 +to do maintenance margin below one hundred because + +225 +00:18:06,320 --> 00:18:09,020 +below one hundred the investor is making profits + +226 +00:18:09,020 --> 00:18:14,400 +بيعمل profits but above one hundred the yes the + +227 +00:18:14,400 --> 00:18:19,240 +broker starting to lose his money so this is why + +228 +00:18:19,240 --> 00:18:23,420 +the maintenance margin is at a price above the one + +229 +00:18:23,420 --> 00:18:26,520 +hundred على سعر أعلى من ال one hundred okay + +230 +00:18:31,390 --> 00:18:35,470 +Okay so now let's carry on the initial price is + +231 +00:18:35,470 --> 00:18:40,530 +one hundred فلو احنا حسبنا حساب بسيط احنا عندنا + +232 +00:18:40,530 --> 00:18:44,270 +الف ساهم من الداية صح one thousand times one + +233 +00:18:44,270 --> 00:18:51,150 +hundred فبطلع عندنا ميت الف دولار صح ال initial + +234 +00:18:51,150 --> 00:18:54,770 +margin fifty percent يعني ال collateral fifty + +235 +00:18:54,770 --> 00:18:59,080 +percent كداش لازم ندفع collateralخمسين ألف فبتكون + +236 +00:18:59,080 --> 00:19:02,340 +عندنا في الخمسين ألف وديه treasure bills any + +237 +00:19:02,340 --> 00:19:07,660 +collateral okay هلأ بضل عندنا احنا نعرف ال .. ال + +238 +00:19:07,660 --> 00:19:10,060 +initial .. ال .. ال .. ال maintenance margin + +239 +00:19:10,060 --> 00:19:14,900 +فاكرين احنا بالأول كنا نحسب ال maintenance margin + +240 +00:19:14,900 --> 00:19:21,040 +طيب هلأ هيفصلناها ال sales proceeds مائة ألف ليها + +241 +00:19:21,040 --> 00:19:25,540 +حسبناها و ال margin and equity fifty percentاللي + +242 +00:19:25,540 --> 00:19:29,940 +هي ال collateral و ال stock owed اللي دياناهم ألف + +243 +00:19:29,940 --> 00:19:36,240 +سهم just for more explanation في حد مش فاهم لحد + +244 +00:19:36,240 --> 00:19:40,820 +اللحظة هذه الأرقام من وين اجت واضحة okay هلا بدنا + +245 +00:19:40,820 --> 00:19:44,180 +نفسر ال asset و ال liabilities ايش ال asset الأصول + +246 +00:19:44,180 --> 00:19:47,700 +بتاعة ال investor ولا الانتزامات العالية لل + +247 +00:19:47,700 --> 00:19:51,400 +investors طيب لو احنا فرضنا + +248 +00:19:55,340 --> 00:20:03,640 +عمل سن العالمية و الأسعار fortunately it's went to + +249 +00:20:03,640 --> 00:20:08,770 +seventy الأسعار نزلت لسبعينكم ربح ال .. ال + +250 +00:20:08,770 --> 00:20:16,210 +industrial؟ تلاتين تلاتين في أكم سحب؟ ألف one + +251 +00:20:16,210 --> 00:20:20,770 +thousand ف تلاتين ألف طيب إذا في ال asset طبعا + +252 +00:20:20,770 --> 00:20:23,550 +توقع تلاتين ألف بس تلاتين ألف في ال asset و الضمان + +253 +00:20:23,550 --> 00:20:30,570 +زائد ضمان خمسين ألف بتطلع كام؟ تمانين ألف هذا إذا + +254 +00:20:30,570 --> 00:20:38,750 +if the price going as he expectedزي إذا كانت + +255 +00:20:38,750 --> 00:20:45,610 +الأسعار زي ما أتوقعنا إذا + +256 +00:20:45,610 --> 00:20:49,510 +كانت الأسعار زي ما أتوقعنا okay so if the price + +257 +00:20:49,510 --> 00:20:54,290 +goes as we expected it means we make a profit + +258 +00:20:54,290 --> 00:20:58,230 +thirty thousand plus fifty thousand is the + +259 +00:20:58,230 --> 00:21:01,790 +collateral so in our assets we will have eighty + +260 +00:21:01,790 --> 00:21:07,440 +thousandof them 30,000 profit and 50,000 as + +261 +00:21:07,440 --> 00:21:11,820 +collateral or as deposit or treasury bills زى ما + +262 +00:21:11,820 --> 00:21:15,660 +تشايفين سبعين + +263 +00:21:15,660 --> 00:21:18,600 +ألف ال liabilities اللى هو سبعين ضرب ال .. okay + +264 +00:21:18,600 --> 00:21:23,540 +اللى هو سبعين ضرب الألف فبصفر عنده تمانين ألف اللى + +265 +00:21:23,540 --> 00:21:28,820 +حسبناها ال equity من وين أجت تلاتين ألف plus fifty + +266 +00:21:28,820 --> 00:21:30,320 +percent طيب + +267 +00:21:36,620 --> 00:21:40,320 +طبعا هاي 80 ألف ناقص ال 50 ألف طلع عنده 30 ألف و + +268 +00:21:40,320 --> 00:21:47,000 +نعرف كيف تعمل و حسبناكوا إياها كيف إجت okay + +269 +00:21:47,000 --> 00:21:52,800 +هلأ ال .. the big question if the prices goes up + +270 +00:21:52,800 --> 00:22:00,740 +إذا كان الأسعار رحت إلى أعلى so in this case the + +271 +00:22:00,740 --> 00:22:04,320 +investor is starting to lose his or her money ال + +272 +00:22:04,320 --> 00:22:09,510 +investors بيبدأ يخسر الفلوس تبعتهour question does + +273 +00:22:09,510 --> 00:22:15,070 +the broker leave him alone؟ هل هيتركه لو واحد + +274 +00:22:15,070 --> 00:22:20,330 +يشتغل؟ no he has to stop him at some places يعني + +275 +00:22:20,330 --> 00:22:25,070 +عند حد معين هيوقفه because he doesn't want him to + +276 +00:22:25,070 --> 00:22:30,170 +lose his money and if he lost his money the lose + +277 +00:22:30,170 --> 00:22:35,040 +will leak to the broker accountsكمان إذا ضالوا + +278 +00:22:35,040 --> 00:22:40,420 +خسرهوا فلوسه الخسائر هتتسرب لل .. لل broker و هذا + +279 +00:22:40,420 --> 00:22:45,140 +بنات احنا بنحكيلكوا كلام هذا عشان كمان انتوا يعني + +280 +00:22:45,140 --> 00:22:49,240 +أكيد بكرا هتشتغلوا في مؤسسات و في كذا و يعني + +281 +00:22:49,240 --> 00:22:55,120 +تكونوا ان شاء الله يعني من السيدات أعمال ان شاء + +282 +00:22:55,120 --> 00:22:58,660 +الله هذا في ethics معلمنا هذا الطريقة فيها ethics + +283 +00:22:58,660 --> 00:23:02,340 +ايش معنى ethics فيها أخلاقيعني لما تشوفوا واحد + +284 +00:23:02,340 --> 00:23:07,620 +تاجر بتاجر غلط و واحد بيخسر فلوسه ما إحنا نستغلهم + +285 +00:23:07,620 --> 00:23:13,080 +at some place we have to stop him لازم نوقفه و + +286 +00:23:13,080 --> 00:23:17,300 +نقوله please روح اتعلم كيف تشتغل بعدين بتيجي لإن + +287 +00:23:17,300 --> 00:23:21,180 +في بعض تجار هيروح يستغله و ياخد فلوسه كلها okay و + +288 +00:23:21,180 --> 00:23:25,600 +ينصب عليه بالعربي و يستغل عدم فهمه بالميكانزم تبع + +289 +00:23:25,600 --> 00:23:30,810 +السوقو هذا بندخل في ال .. في عدم الأخلاق .. عدم + +290 +00:23:30,810 --> 00:23:34,310 +أخلاقية المهنة فهون بال .. بال .. بال financial + +291 +00:23:34,310 --> 00:23:38,670 +market at some place they have to stop him and to + +292 +00:23:38,670 --> 00:23:42,570 +ask him to leave the markets أو حابب يتضلق في + +293 +00:23:42,570 --> 00:23:47,150 +السوق okay bring cash يعني bring cash it's like to + +294 +00:23:47,150 --> 00:23:50,050 +pressurize on him to leave the markets يعني كأنه + +295 +00:23:50,050 --> 00:23:52,070 +بطريقة أخرى بيقوله امشي + +296 +00:23:54,470 --> 00:24:00,030 +Okay so our question at what price they ask for + +297 +00:24:00,030 --> 00:24:03,690 +maintenance margin فهنحسبها المعادلة اللي أخدناها + +298 +00:24:03,690 --> 00:24:10,190 +بتاعت زمان اللي هو زي ما أنتوا شايفين فاكرين ال + +299 +00:24:10,190 --> 00:24:16,650 +150 ألف من وين إجت؟ إجت من ال .. ال .. اللي هو + +300 +00:24:16,650 --> 00:24:23,920 +number of shares ضرب ل priceاللي هو ضرب ال price + +301 +00:24:23,920 --> 00:24:27,180 +المعادلة اللي أعطاناها هي زائد ال collateral ال + +302 +00:24:27,180 --> 00:24:31,720 +collateral خمسين ألف فهي مية plus خمسين اللي هو + +303 +00:24:31,720 --> 00:24:39,120 +مية و خمسين ألف okay minus الف P okay ال الف P + +304 +00:24:39,120 --> 00:24:42,260 +اللي هو number of shares ضرب ال price اللي احنا مش + +305 +00:24:42,260 --> 00:24:46,480 +عارفينه اللي احنا هنوجده تقسيم ال الف P بتساوي + +306 +00:24:46,480 --> 00:24:53,490 +thirty percent لو احنا حسبناهانحسبها مع بعض 150000 + +307 +00:24:53,490 --> 00:25:06,230 +-1000P تقسيم 1000P بتساوي 30% صح؟ ال 1000P بتيجي + +308 +00:25:06,230 --> 00:25:18,530 +مع ال 30% بتصير ايش؟ 300P بتساوي 150000-1000P + +309 +00:25:20,270 --> 00:25:28,050 +الألف بتيجي هان بتسيي ال 700P بتساوي 150 ألف من + +310 +00:25:28,050 --> 00:25:36,210 +نحكي ال 150 ألف 150 ألف تقسيم 700 بتساوي ال P من + +311 +00:25:36,210 --> 00:25:43,330 +هن بنعرف ال P قسم ال 150 ألف على 700 كم؟ لأ في إيش + +312 +00:25:43,330 --> 00:25:45,350 +غلط يكون 115 + +313 +00:25:50,840 --> 00:25:55,220 +احنا هان كام؟ ألف ألف + +314 +00:25:55,220 --> 00:26:01,640 +بي بتساوي 30% 30% بتضربها في الألف تلاتين في المية + +315 +00:26:01,640 --> 00:26:08,580 +ضرب الألف تلاتمية بي okay تلاتمية بي بتساوي مية و + +316 +00:26:08,580 --> 00:26:14,220 +خمسين ألف ناقص الألف بي فالألف بي بتيجي هان بتصير + +317 +00:26:14,220 --> 00:26:20,730 +ألف تلاتمية بي بتساوي مية و خمسين ألف صح؟فالمية و + +318 +00:26:20,730 --> 00:26:27,370 +خمسين ألف على الف و تلات مية okay جاوبوا شوفوا هيش + +319 +00:26:27,370 --> 00:26:36,410 +ال .. تطلع مية و خمستاشر okay ده + +320 +00:26:36,410 --> 00:26:39,450 +بس نجلة الإشارة بتاع اللغة okay + +321 +00:26:45,250 --> 00:26:50,230 +فبتطلع 150 ألف على 1300 بتطلع 115 طيب إيش هي ال + +322 +00:26:50,230 --> 00:26:56,230 +115 لو أحنا لسمناها على بسم البياني هان ال 115 + +323 +00:26:56,230 --> 00:27:02,530 +اللي above هان لازم يكون عنده ال initial margin + +324 +00:27:02,530 --> 00:27:10,750 +بيكون كام خسر 115 بيكون 15 خسر 15 دولار ضرب ال + +325 +00:27:10,750 --> 00:27:19,130 +100015000 عشان كمل احنا اه طيب طب كام بيبقى في ال + +326 +00:27:19,130 --> 00:27:25,430 +equity تبعته كام برصيد ال investor 50000 بيكون + +327 +00:27:25,430 --> 00:27:34,170 +عنده 50000 ناقص ال 15000 بيطلع 35000 طب كام نسبة + +328 +00:27:34,170 --> 00:27:40,070 +الخسارة نسبة الخسارة كام اللي هو فاكرين لما كنا + +329 +00:27:40,070 --> 00:27:48,380 +نعود B1minus P note على P note صح اه yes okay فهو + +330 +00:27:48,380 --> 00:27:52,540 +كان عنده خمسين الف بدأ بالخمسين الف خمسين الف + +331 +00:27:52,540 --> 00:28:00,620 +وخسرها اللي هو الخمستاشر الف okay فنسبة الخسارة + +332 +00:28:00,620 --> 00:28:04,780 +اللي هي عندها خمستاشر الف من ناقص على الخمسين الف + +333 +00:28:04,780 --> 00:28:11,100 +okay بطلع خسر كام من ثرواته حوالي اكتر من تلاتين + +334 +00:28:11,100 --> 00:28:16,130 +فميةمصبوط؟ يعني لإنه خمستاشر واحد خمسة وأربعين + +335 +00:28:16,130 --> 00:28:20,470 +يعني حوالي أكتر من تلاتين فمية خسر من الثروة تبعته + +336 +00:28:20,470 --> 00:28:25,870 +تلاتين فمية بالظبط يعني خسر من الثروة تبعته + +337 +00:28:25,870 --> 00:28:33,570 +لإندستور تلاتين فمية تمام؟ + +338 +00:28:33,570 --> 00:28:36,850 +أي + +339 +00:28:36,850 --> 00:28:37,410 +سؤال؟ + +340 +00:28:42,480 --> 00:28:56,900 +حسين تصفر علينا حد + +341 +00:28:56,900 --> 00:28:58,820 +عنده سؤال .. حد عنده سؤال هان + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/B-QGYVkzr-s.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/B-QGYVkzr-s.srt new file mode 100644 index 0000000000000000000000000000000000000000..fd079f4422de2f0a5596db6a191160a628a8c4a1 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/B-QGYVkzr-s.srt @@ -0,0 +1,1663 @@ +1 +00:00:21,260 --> 00:00:25,140 +بسم الله الرحمن الرحيم in the last meeting we + +2 +00:00:25,140 --> 00:00:28,800 +talked about the active or passive managers or + +3 +00:00:28,800 --> 00:00:31,780 +managements the main difference between active and + +4 +00:00:31,780 --> 00:00:34,320 +passive **in** regard to what extent the market is + +5 +00:00:34,320 --> 00:00:37,360 +efficient يعني الفرق بين الـ active و الـ + +6 +00:00:37,360 --> 00:00:41,500 +passive لأي درجة الـ market is efficient لأي + +7 +00:00:41,500 --> 00:00:46,540 +درجة السوق المالي كفوء طبعا فالـ active + +8 +00:00:46,540 --> 00:00:49,820 +managers think that the market is not efficient + +9 +00:00:51,080 --> 00:00:55,340 +however the passive managers think the market is + +10 +00:00:55,340 --> 00:01:02,960 +efficient يعني المدراء اللي بيعملوا دائما تغيير في + +11 +00:01:02,960 --> 00:01:06,900 +الـ portfolios تبعتهم بيعتقدوا الـ market ليس كفوء + +12 +00:01:06,900 --> 00:01:11,740 +لكن الـ managers المدراء اللي + +13 +00:01:11,740 --> 00:01:14,120 +هم ما بيغيروا بالـ portfolios تبعتهم و passive + +14 +00:01:14,120 --> 00:01:17,660 +بيكونوا سلبيين لتغيرات السوق بيعتقدوا أن الـ market + +15 +00:01:17,660 --> 00:01:20,740 +is efficient and we don't need to rebalance + +16 +00:01:20,740 --> 00:01:23,380 +our portfolios or to follow up the information + +17 +00:01:23,380 --> 00:01:26,380 +وما بيزامش كثير أن احنا نـ نتابع + +18 +00:01:26,380 --> 00:01:30,000 +المعلومات market efficiency and portfolio + +19 +00:01:30,000 --> 00:01:34,300 +management let's consider the relationship between + +20 +00:01:34,300 --> 00:01:37,560 +the market efficiency and the portfolio management + +21 +00:01:37,560 --> 00:01:40,780 +حكينا portfolio management اللي هو إدارة المحفظة + +22 +00:01:40,780 --> 00:01:45,840 +يمكن مش واضحة عندكم what it means portfolio خلينا + +23 +00:01:45,840 --> 00:01:50,280 +نفترض فرضية بسيطة لو كان أنا معايا 1000$ ألف دولار + +24 +00:01:50,280 --> 00:01:54,860 +I have two options to invest all of them in one + +25 +00:01:54,860 --> 00:01:59,390 +stock or one security إنه أنا أستثمرهم كلهم في one + +26 +00:01:59,390 --> 00:02:03,970 +security in one single stock يعني أستثمر كل الـ one + +27 +00:02:03,970 --> 00:02:10,970 +thousand dollar في سهم واحد the problem of this is + +28 +00:02:10,970 --> 00:02:15,750 +not considering the importance of risk يعني لو + +29 +00:02:15,750 --> 00:02:24,380 +كانت a ارتفعت is fine but when a is going down this + +30 +00:02:24,380 --> 00:02:28,420 +investor will lose his or her all money يعني الـ + +31 +00:02:28,420 --> 00:02:33,930 +investor هيخسر كل فلوسه but if we invest this is if + +32 +00:02:33,930 --> 00:02:37,590 +we invest in one single security إذا احنا بنستثمر + +33 +00:02:37,590 --> 00:02:41,490 +في سهم واحد but in the portfolio management لكن + +34 +00:02:41,490 --> 00:02:46,290 +الإدارة الاستثمارية built on the notion مبنية على + +35 +00:02:46,290 --> 00:02:51,190 +فكرة that don't put your eggs on one basket يعني + +36 +00:02:51,190 --> 00:02:54,650 +مانحطش البيض كله تبعنا في سلة واحدة so we can + +37 +00:02:54,650 --> 00:02:59,700 +invest on a portfolio this portfolio includes C, B, + +38 +00:03:00,340 --> 00:03:07,440 +A, X, Y for instance if A is going down maybe X is + +39 +00:03:07,440 --> 00:03:12,540 +going up, C is going up, Y going up and maybe B is + +40 +00:03:12,540 --> 00:03:17,970 +going down so it means yes so it's like is good for + +41 +00:03:17,970 --> 00:03:21,230 +managing the risk إذا كويسة بتكون في managing the + +42 +00:03:21,230 --> 00:03:24,050 +risk so this is the importance of the portfolio + +43 +00:03:24,050 --> 00:03:27,890 +the portfolio the main importance of the portfolio + +44 +00:03:27,890 --> 00:03:32,090 +is to increase the interest rate increase the rate of + +45 +00:03:32,090 --> 00:03:34,950 +return and decrease the risk يعني الهدف في النهاية + +46 +00:03:34,950 --> 00:03:37,570 +تبع الـ portfolio المحفظة أن احنا نزيد العائد و + +47 +00:03:37,570 --> 00:03:41,970 +نقلل المخاطر and in the chapter five and six we + +48 +00:03:41,970 --> 00:03:45,060 +will see how we can manage this في chapter خمسة و + +49 +00:03:45,060 --> 00:03:48,280 +ستة هنشوف كيف أنه احنا هنعمل managing للـ portfolio + +50 +00:03:48,280 --> 00:03:55,240 +okay so the thing is the link between the market + +51 +00:03:55,240 --> 00:03:58,880 +efficiency and portfolio management enable the + +52 +00:03:58,880 --> 00:04:03,880 +investor to diversify their securities بيقدروا + +53 +00:04:03,880 --> 00:04:07,620 +ينوعوا فاحنا في الـ portfolios احنا في عندنا C في + +54 +00:04:07,620 --> 00:04:10,820 +عندنا D في عندنا A في عندنا X و عندنا Y لأنه الـ + +55 +00:04:10,820 --> 00:04:14,020 +market is efficient and we know the rate of return + +56 +00:04:14,020 --> 00:04:17,340 +of C, we know the risk, we know the rate of return + +57 +00:04:17,340 --> 00:04:20,760 +of Y, we know the risk, we know everything so this + +58 +00:04:20,760 --> 00:04:25,660 +enable us to do diversification diversification it + +59 +00:04:25,660 --> 00:04:29,720 +means تنويع بنقدر احنا ننوع not only the + +60 +00:04:29,720 --> 00:04:33,440 +diversification on the securities on the stocks مش + +61 +00:04:33,440 --> 00:04:36,420 +بس أن احنا بنقدر نعمل تنويع بالـ stocks بالأسهم + +62 +00:04:36,420 --> 00:04:41,420 +ممكن we can create another portfolio ممكن أن احنا + +63 +00:04:41,420 --> 00:04:46,380 +نعمل portfolio أخرى includes stocks for instance A + +64 +00:04:46,380 --> 00:04:51,540 +,B,R stocks we can include the treasury bills we + +65 +00:04:51,540 --> 00:04:56,840 +can include bonds يعني ممكن احنا كمان ننوع بأنواع + +66 +00:04:56,840 --> 00:04:59,520 +الـ securities نعمل diversification نعمل تنويع حسب + +67 +00:04:59,520 --> 00:05:03,600 +نوع الـ securities ممكن احنا نحط أسهم و نحط سندات و + +68 +00:05:03,600 --> 00:05:08,020 +نحط treasure bins و سندات خزينة we can also build + +69 +00:05:08,020 --> 00:05:10,880 +another portfolio based on the geographic areas + +70 +00:05:10,880 --> 00:05:17,060 +حسب التنويع الجغرافي for instance united states + +71 +00:05:17,060 --> 00:05:22,020 +stocks ممكن نحط أسهم بتاعي على الـ united states UK + +72 +00:05:22,020 --> 00:05:28,360 +stocks Asian, Asians stock أسهم آسيوية for instance + +73 +00:05:28,360 --> 00:05:33,620 +نحط مثلا من Tokyo، من Japan، من دبي، من قطر، the + +74 +00:05:33,620 --> 00:05:40,640 +king سعودي we can include other areas in our + +75 +00:05:40,640 --> 00:05:44,040 +portfolios ممكن احنا نوّع المحفظة الاستثمارية ممكن + +76 +00:05:44,040 --> 00:05:46,280 +ناخد أسهم من الولايات المتحدة الأمريكية أسهم من + +77 +00:05:46,280 --> 00:05:50,460 +الأوروبـا أسهم من الـ UK أسهم من السعودية من دبي من + +78 +00:05:50,460 --> 00:05:55,240 +قطر من Tokyo من ماليزيا فهي بيسموها تنويع جغرافي + +79 +00:05:55,240 --> 00:06:03,650 +okay هذه هي الـ hypothesis التسريحية التي تساعدنا في + +80 +00:06:03,650 --> 00:06:09,010 +تدفع ميزاتنا باستخدام الأمن باستخدام المناطق + +81 +00:06:09,010 --> 00:06:13,510 +الجغرافية باستخدام رغبات الأمن على سبيل المثال + +82 +00:06:13,510 --> 00:06:20,650 +نستطيع إنشاء ميزاتنا باستخدام على سبيل المثال + +83 +00:06:20,650 --> 00:06:30,350 +أصول رخية و أصول خفية يعني ممكن احنا نعمل + +84 +00:06:30,350 --> 00:06:34,170 +portfolio جزء منها assets فيها مخاطر و assets + +85 +00:06:34,170 --> 00:06:38,610 +مافيهاش فيها مخاطر okay فزي ما أنتو شايفين الـ + +86 +00:06:38,610 --> 00:06:43,290 +investors are free to form up their portfolios أن + +87 +00:06:43,290 --> 00:06:47,990 +المستثمرين هم أحرار في يكونوا الـ portfolios تبعتهم + +88 +00:06:47,990 --> 00:06:52,350 +ممكن يعملوا جغرافية تنمية جغرافية ممكن they can + +89 +00:06:52,350 --> 00:06:56,950 +also diversify their portfolios based on the + +90 +00:06:56,950 --> 00:07:01,080 +industrial level ممكن حسب الـ industrial level ممكن + +91 +00:07:01,080 --> 00:07:05,480 +هم يستثمروا مثلا في الـ agriculture في الزراعة ممكن + +92 +00:07:05,480 --> 00:07:11,900 +في الـ tourist السياحة ممكن يستثمروا في الـ industry + +93 +00:07:11,900 --> 00:07:16,640 +الصناعة ممكن في الـ telecommunication okay so they + +94 +00:07:16,640 --> 00:07:19,980 +don't need to to channel their funds to a + +95 +00:07:19,980 --> 00:07:25,000 +particular industry يعني مابيحتاجوش أن فقط يروحوا + +96 +00:07:25,000 --> 00:07:28,490 +يستثمروا only in the telecommunication because if + +97 +00:07:28,490 --> 00:07:31,690 +they invest in only the telecommunication it means + +98 +00:07:31,690 --> 00:07:34,590 +they only taking the risk of the telecommunication + +99 +00:07:34,590 --> 00:07:37,310 +and if the telecommunication is going down all of + +100 +00:07:37,310 --> 00:07:39,930 +their portfolios is going down so they need to + +101 +00:07:39,930 --> 00:07:42,830 +diversify their portfolios based on the industrial + +102 +00:07:42,830 --> 00:07:46,830 +level فعشان هيك هم محتاجين كمان يعملوا تنويع في + +103 +00:07:46,830 --> 00:07:49,610 +المحفظة حسب الـ industrial level يعني بيستثمروا في + +104 +00:07:49,610 --> 00:07:52,800 +العقارات في الـ real estates ممكن يستثمروا في الـ + +105 +00:07:52,800 --> 00:07:55,800 +currencies، في العملات، ممكن يستثمروا في السياحة، + +106 +00:07:55,800 --> 00:07:58,560 +يستثمروا في الصناعة، في الـ telecommunication، في + +107 +00:07:58,560 --> 00:08:01,640 +.. في كل هذه يكونوا محافظ استثمارية، فإذا كانت الـ + +108 +00:08:01,640 --> 00:08:04,720 +telecommunication is going down ممكن يكون في other + +109 +00:08:04,720 --> 00:08:09,520 +areas is going up، يعني areas أخرى بتطلع .. تطلع، + +110 +00:08:09,520 --> 00:08:13,080 +فهذه بدأت أخد بعين الأعتبار، إذا هذه some examples + +111 +00:08:13,080 --> 00:08:17,850 +on how investors forming up their + +112 +00:08:17,850 --> 00:08:21,370 +portfolios كيف هم بيكونوا المحفظة الاستثمارية + +113 +00:08:21,370 --> 00:08:27,610 +بناء على شو هم بدهم Okay ف the efficient markets + +114 +00:08:27,610 --> 00:08:32,390 +helping them to forming a good diversified + +115 +00:08:32,390 --> 00:08:36,730 +portfolio لتساعدهم بأنهم يحصلوا على تنويع ممتاز من + +116 +00:08:36,730 --> 00:08:39,670 +المحفظة الاستثمارية and as I said the main + +117 +00:08:39,670 --> 00:08:43,310 +objective of doing this is to reduce the risk يعني + +118 +00:08:43,310 --> 00:08:47,330 +الهدف أن احنا نخفض المخاطر اللي بتتحملها الـ + +119 +00:08:47,330 --> 00:08:53,370 +investors The second most important thing is + +120 +00:08:53,370 --> 00:08:57,990 +appropriate risk level if we look at the + +121 +00:08:57,990 --> 00:09:03,890 +portfolios the investors they try to assign which + +122 +00:09:03,890 --> 00:09:08,490 +risk they can apply + +123 +00:09:08,490 --> 00:09:12,190 +يعني بيقدروا من خلال الـ portfolio يقولوا احنا بدنا + +124 +00:09:12,190 --> 00:09:16,680 +مخاطر X فبيقدروا يعملوا الـ portfolios تبعتهم + +125 +00:09:16,680 --> 00:09:21,080 +according to the X risk يعني بتوفر لهم ال + +126 +00:09:21,080 --> 00:09:24,740 +portfolio management إنه بالظبط يقدروا يكونوا + +127 +00:09:24,740 --> 00:09:32,140 +محافظ استثمارية with unknown risk يعني بيقدروا + +128 +00:09:32,140 --> 00:09:36,240 +يعملوا محافظ استثمارية معروفة المخاطر Okay فالأسواق + +129 +00:09:36,240 --> 00:09:39,600 +المالية بتساعدهم على الكلام هذا and they use + +130 +00:09:39,600 --> 00:09:42,060 +advanced calculations بيستخدموا الـ advanced + +131 +00:09:42,060 --> 00:09:47,080 +calculations to do this يعني رياضيات متقدمة عشان + +132 +00:09:47,080 --> 00:09:50,220 +يحصلوا على الـ appropriate risk يعني مثلا خليني + +133 +00:09:50,220 --> 00:09:56,160 +أعطيكم مثال لو أجاني investors شوفوا كيف مثلا + +134 +00:09:56,160 --> 00:10:03,650 +خليني .. لو أجاني أنا channel investors from + +135 +00:10:03,650 --> 00:10:09,830 +different origins يعني مستثمرين من من مختلف الـ + +136 +00:10:09,830 --> 00:10:16,630 +origins المصادر okay مثلا عندنا I one investor one + +137 +00:10:16,630 --> 00:10:22,990 +I two investor two I three I four I five till I + +138 +00:10:22,990 --> 00:10:31,450 +end for instance I one is old old man لو كان الـ I + +139 +00:10:31,450 --> 00:10:35,630 +one investor number one is old man رجل كبير and I + +140 +00:10:35,630 --> 00:10:42,770 +two is old lady I five for instance is young with + +141 +00:10:42,770 --> 00:10:48,070 +a secure job okay + +142 +00:10:48,070 --> 00:10:56,890 +and I four is young lady with a secure job as well + +143 +00:10:56,890 --> 00:11:00,690 +so let's see how we can reflect appropriate level + +144 +00:11:00,690 --> 00:11:03,270 +of risk according to the characteristics of the + +145 +00:11:03,270 --> 00:11:06,310 +investors يعني خليني أشوف كيف احنا ممكن نعمل محفظة + +146 +00:11:06,310 --> 00:11:13,170 +استثمارية حسب المخاطر بتاعة الـ investors okay طيب + +147 +00:11:13,170 --> 00:11:15,330 +هلأ لو نيجي احنا نيجي handle الـ old men and old + +148 +00:11:15,330 --> 00:11:19,750 +ladies هدول بتحمل المخاطر؟شو رأيكم؟ زلمة كبيرة و + +149 +00:11:19,750 --> 00:11:22,390 +ستة كبيرة يعني retired people يعني خلينا نحكي هنا + +150 +00:11:22,390 --> 00:11:28,690 +number .. I3 retired lady يعني ستة تقاعدت يعني + +151 +00:11:28,690 --> 00:11:33,810 +كانت تشتغل و صار عندها تقاعد شو رأيكم؟الـ old man و + +152 +00:11:33,810 --> 00:11:38,150 +الـ old lady و الـ retired lady هدول بتحملوش مخاطر + +153 +00:11:38,150 --> 00:11:42,210 +فإحنا إيش بنعملهم محفظة ناخدهم هدول مع بعض و + +154 +00:11:42,210 --> 00:11:46,130 +بنعملهم محفظة with lower risk بنعملهم محفظ + +155 +00:11:46,130 --> 00:11:49,670 +استثماري with lower risk طب إيش بنستثمرهم؟ إيش الـ + +156 +00:11:49,670 --> 00:11:53,420 +investment اللي فيه lower risk؟الـ treasury bills، + +157 +00:11:53,420 --> 00:11:56,440 +مظبوط، فيه lower risk، إيش فيه كمان؟ الـ bonds، + +158 +00:11:56,440 --> 00:12:01,880 +فيها lower risk، إيش كمان؟ عقد ثابت، إيش رأيكم؟ الـ + +159 +00:12:01,880 --> 00:12:04,420 +derivatives، نحطولهم في الـ derivatives؟ نستثمرهم + +160 +00:12:04,420 --> 00:12:07,880 +في الـ derivatives؟ no, لأن الـ derivatives ..high + +161 +00:12:07,880 --> 00:12:12,580 +risk طيب وش كمان ممكن نعطيهم real estate عقارات + +162 +00:12:12,580 --> 00:12:15,500 +استثمروا بالعقارات so this is the thing so we + +163 +00:12:15,500 --> 00:12:19,000 +forming up this portfolio by using for instance + +164 +00:12:19,000 --> 00:12:21,980 +treasury bills which is risk free maybe treasury + +165 +00:12:21,980 --> 00:12:28,160 +bonds and real estate this is the example okay + +166 +00:12:28,160 --> 00:12:33,600 +let's consider the I4 and I5 I5 young man and + +167 +00:12:33,600 --> 00:12:39,480 +young lady with a secure job صغار و عندهم شغلهم + +168 +00:12:39,480 --> 00:12:43,400 +okay so they can bear more risk so they can bear + +169 +00:12:43,400 --> 00:12:46,280 +more risk يعني ممكن يتحملوا or they hold they may + +170 +00:12:46,280 --> 00:12:50,540 +hold more risk فممكن يتحملوا مخاطر أعلى so وين + +171 +00:12:50,540 --> 00:12:53,240 +ممكن يستثمروا ممكن في الـ stocks يستثمروا بالـ + +172 +00:12:53,240 --> 00:12:57,240 +stocks ممكن بالـ currencies ممكن يستثمروا ممكن في + +173 +00:12:57,240 --> 00:13:02,800 +الـ derivatives okay that's it يعني شفنا احنا how + +174 +00:13:02,800 --> 00:13:09,000 +we reflect this إذن حسب the characteristics of the + +175 +00:13:09,000 --> 00:13:14,240 +investors so we can forming up the appropriate + +176 +00:13:14,240 --> 00:13:18,040 +portfolio with appropriate risk يعني ممكن إحنا + +177 +00:13:18,040 --> 00:13:22,500 +ننشأ محافظة استثمارية حسب الـ investors اللي سبعونا + +178 +00:13:22,500 --> 00:13:27,560 +وحسب المخاطر اللي هم ممكن يتحملوها okay so this is + +179 +00:13:27,560 --> 00:13:32,660 +the appropriate risk level the last one is tax + +180 +00:13:32,660 --> 00:13:36,890 +considerations tax tax consideration okay let's + +181 +00:13:36,890 --> 00:13:39,370 +focus on the importance of tax considerations + +182 +00:13:39,370 --> 00:13:44,950 +خلّيني أركز على الـ tax considerations يعني + +183 +00:13:44,950 --> 00:13:54,930 +الاعتبارات الضريبية طيب + +184 +00:13:54,930 --> 00:14:03,980 +خلّيني أخد مثال احنا عندنا stock A stock A بيوزع + +185 +00:14:03,980 --> 00:14:13,360 +dividends، الـ stock A نفسه ممكن + +186 +00:14:13,360 --> 00:14:19,040 +ما يدفع dividends، no dividends، نشوف what is the + +187 +00:14:19,040 --> 00:14:21,860 +difference when the stock A paying dividends and + +188 +00:14:21,860 --> 00:14:24,840 +when the stock A paying no dividends يعني إيش + +189 +00:14:24,840 --> 00:14:28,560 +الفرق بإنه الشركة تدفع أرباح .. تدفع توزيعات أرباح + +190 +00:14:28,560 --> 00:14:33,140 +و ما تدفعش؟the dividends when the investors + +191 +00:14:33,140 --> 00:14:37,600 +receiving the dividends they have to pay tax لازم + +192 +00:14:37,600 --> 00:14:45,700 +يدفعوا ضريبة and this tax is maybe 25% هبتصل this + +193 +00:14:45,700 --> 00:14:50,280 +tax in the united states this the tax income is up + +194 +00:14:50,280 --> 00:14:54,520 +to 25% and in the UK as well يعني في الولايات + +195 +00:14:54,520 --> 00:14:59,600 +المتحدة الأمريكية و الـ .. و الـ .. و الـ UK بتصل ل + +196 +00:14:59,600 --> 00:15:05,480 +25% فاللي مثلا لو احنا we receive 10$ as a + +197 +00:15:05,480 --> 00:15:11,540 +dividends we have to pay 2.5$ as a tax okay this + +198 +00:15:11,540 --> 00:15:16,760 +is the .. this is the problem in the opposite if a + +199 +00:15:16,760 --> 00:15:24,000 +being no dividends it means there is no tax طيب + +200 +00:15:24,000 --> 00:15:26,660 +what is the alternative of not paying the + +201 +00:15:26,660 --> 00:15:31,840 +dividends؟ شو البديل أنه احنا ماددفعش نوزعش أرباح؟ + +202 +00:15:31,840 --> 00:15:36,400 +فضل ازاي + +203 +00:15:36,400 --> 00:15:41,860 +صح كلامك بس ازاي انا احكي لك لما احنا ماددفعش + +204 +00:15:41,860 --> 00:15:45,840 +الأرباح انا محتجزة بيصير في 110 earnings أرباح + +205 +00:15:45,840 --> 00:15:50,200 +محتجزة اه بتكون قصود احنا الأصل هو عبارة عن قيمة + +206 +00:15:50,200 --> 00:15:57,970 +الفرق من القصود او قيمته بصير ايش؟بتزيد المكية + +207 +00:15:57,970 --> 00:16:02,470 +بتزيد حصته بس هذا from the financial perspective + +208 +00:16:02,470 --> 00:16:05,770 +this is from the corporate finance perspective هذا + +209 +00:16:05,770 --> 00:16:08,970 +من غير نظر corporate finance but from the + +210 +00:16:08,970 --> 00:16:12,430 +financial market perspective you are right but + +211 +00:16:12,430 --> 00:16:14,990 +from the financial market perspective let's see + +212 +00:16:14,990 --> 00:16:19,050 +what is going خلينا نشوف الـ A بتدفع dividends فهم + +213 +00:16:19,050 --> 00:16:22,170 +بدفعوا taxation فالـ investors اللي بتثمروا في A و + +214 +00:16:22,170 --> 00:16:28,010 +اللي بتدفع dividends فهيدفعوا 25% taxation if a + +215 +00:16:28,010 --> 00:16:31,310 +decided not paying any dividends إذا هم قرروا + +216 +00:16:31,310 --> 00:16:34,550 +مايدفعوش dividends خلينا نشوف لو أنتوا شفتوا الـ + +217 +00:16:34,550 --> 00:16:40,550 +assets و الـ liabilities مظبوط؟فلما أنا ب .. بعمل + +218 +00:16:40,550 --> 00:16:46,310 +no dividends فبعمل احتجاز للأرباح فبتروحها تحت الـ + +219 +00:16:46,310 --> 00:16:49,730 +capital as she said تحت الـ capital بيصير في return + +220 +00:16:49,730 --> 00:16:53,910 +earnings طيب let's ask you a question return + +221 +00:16:53,910 --> 00:16:57,250 +earnings what is the importance of return earnings + +222 +00:16:57,250 --> 00:17:00,890 +خلينا سؤال finance إيش أهمية الـ return earnings + +223 +00:17:00,890 --> 00:17:05,370 +ليش .. ليش الشركات بتعمل investment is for + +224 +00:17:05,370 --> 00:17:10,800 +expansion expansion يعني توسع صح ولا لأ Okay فالان + +225 +00:17:10,800 --> 00:17:16,120 +لما الشركات بتروح بتعمل keeping the profit it + +226 +00:17:16,120 --> 00:17:19,820 +means return earnings it means in the future they + +227 +00:17:19,820 --> 00:17:22,440 +may invest this money في المستقبل هم هيتستثمروا + +228 +00:17:22,440 --> 00:17:28,420 +الأموال because they keep this the price of the + +229 +00:17:28,420 --> 00:17:32,380 +stocks is going up لما الشركات تحتجز الأرباح + +230 +00:17:32,380 --> 00:17:36,060 +فالمستثمرين مقتنعين ان هاي الشركات لما تحتجز + +231 +00:17:36,060 --> 00:17:38,520 +الأرباح هتعمل expansion ايش يعني expansion يعني + +232 +00:17:38,520 --> 00:17:42,830 +توسع طب لأنه بده تعمل expansion فبصير الـ investors + +233 +00:17:42,830 --> 00:17:46,990 +معنيين بالشركة هذه بتعرفوا أن الشركة هذه مثلا نيجي + +234 +00:17:46,990 --> 00:17:50,910 +بالتل عاملة تحتجز أرباح و بتفكر أنه تروح تعمل مثلا + +235 +00:17:50,910 --> 00:17:55,390 +a new investment فإيش اللي بيصير على الـ price إيش + +236 +00:17:55,390 --> 00:17:58,490 +الـ price السعر؟ شو بيصير فيه؟ going up بصير ارتفاع + +237 +00:17:58,490 --> 00:18:05,070 +طيب خليني عشان انا بتواصلكم فكرة معينة هلأ instead + +238 +00:18:05,070 --> 00:18:09,640 +of paying dividends بدل ما احنا ندفع dividends we + +239 +00:18:09,640 --> 00:18:14,980 +are keeping the profits مظبوط keeping the profits + +240 +00:18:14,980 --> 00:18:20,740 +اللي هو بانجو سان نسميها returned earnings اللي هو + +241 +00:18:20,740 --> 00:18:26,020 +احتجاز أربعة طيب هلأ حكينا 25% اللي ندفعه على الـ + +242 +00:18:26,020 --> 00:18:29,220 +dividend tax لما نعمل keeping the profits مع + +243 +00:18:29,220 --> 00:18:34,340 +الكلام we do expansion نعمل expansion توسع + +244 +00:18:36,580 --> 00:18:43,140 +لما يعمل توسع الـ investors think that the income + +245 +00:18:43,140 --> 00:18:46,720 +will increase لما الـ investors بيعرفوا أن الشركة + +246 +00:18:46,720 --> 00:18:50,460 +هي هتعمل توسع الأربعة هتزيد صح ولا لأ؟because they + +247 +00:18:50,460 --> 00:18:53,620 +think the income increase the price will going up + +248 +00:18:53,620 --> 00:18:58,500 +السعر هيرتفع okay what this means from the + +249 +00:18:58,500 --> 00:19:01,300 +financial market perspective هذا إيش معنى الكلام + +250 +00:19:01,300 --> 00:19:04,300 +من وجهة نظر الـ financial perspective الـ financial + +251 +00:19:04,300 --> 00:19:09,700 +perspective saying that it means R the return on a + +252 +00:19:09,700 --> 00:19:13,900 +particular asset R of A this is from mathematical + +253 +00:19:13,900 --> 00:19:16,740 +perspective من وجهة نظر المحاسبية financial + +254 +00:19:16,740 --> 00:19:19,780 +mathematical perspective من وجهة نظر المالية + +255 +00:19:19,780 --> 00:19:23,220 +المحاسبية RA اللي هو السهم A اللي احنا حكينا فيه + +256 +00:19:23,220 --> 00:19:33,080 +بساوي D one D plus P one minus P not what it means + +257 +00:19:33,080 --> 00:19:41,760 +العائد بتاع RA هيساوي ال dividends على زائد price one + +258 +00:19:41,760 --> 00:19:45,960 +سعر البيع ناقص سعر الشراء معنى الكلام أنه احنا + +259 +00:19:45,960 --> 00:19:50,540 +العائد تبع السهم بنحصله من مكانين من ال dividends + +260 +00:19:50,540 --> 00:19:56,520 +و من ال capital gains هذا بيسموها capital gains + +261 +00:19:56,520 --> 00:20:02,320 +ليش سميناها capital gains لأنه احنا اشترينا السهم + +262 +00:20:02,320 --> 00:20:06,480 +على سعره لما صار في keeping the profit هنبيعه على + +263 +00:20:06,480 --> 00:20:12,020 +سعر أعلى okay طب لنفترض احنا هنا حكينا ال tax high + +264 +00:20:12,020 --> 00:20:15,840 +ال tax في حالة ال dividends is greater than the + +265 +00:20:15,840 --> 00:20:18,960 +capital gains ال tax في حالة ال dividends is + +266 +00:20:18,960 --> 00:20:22,100 +greater than the capital gains الحكومة الأمريكية و + +267 +00:20:22,100 --> 00:20:26,220 +البريطانية و حتى اللي عندنا و ال local governments + +268 +00:20:26,220 --> 00:20:30,800 +و الحكومات المحلية عندنا بتفرض ضرائب أعلى على ال + +269 +00:20:30,800 --> 00:20:36,040 +dividends فبصير إنه الاهتمام بال capital gains أكثر + +270 +00:20:36,040 --> 00:20:42,120 +من اهتمام بال dividends okay so the thing is some + +271 +00:20:42,120 --> 00:20:48,020 +investors they prefer to take dividends but the + +272 +00:20:48,020 --> 00:20:54,520 +problem is paying more tax بعض المستثمرين يفضلوا + +273 +00:20:54,520 --> 00:20:57,660 +ال dividends لكن المشكلة إيش في ال dividends تدفع + +274 +00:20:57,660 --> 00:21:01,780 +ضريبة عالية they have to do this يعني نرجع لمثالنا + +275 +00:21:01,780 --> 00:21:06,740 +إذا كانت راجل كبير و ست كبيرة بيفضلوا ال dividends + +276 +00:21:06,740 --> 00:21:10,360 +ما بيفضلوش إن الشركات تروح تترسم للأربعة واحدة + +277 +00:21:10,360 --> 00:21:15,120 +بعدها بفضلوا كل شهرين تلاتة يجي لهم dividends لكن + +278 +00:21:15,120 --> 00:21:19,860 +المشكلة هذه they have to pay high tax لكن بواجهوا + +279 +00:21:19,860 --> 00:21:21,560 +مشكلة إنه بدفعوا ضريبة عالية + +280 +00:21:24,390 --> 00:21:28,350 +people they prefer the capital gains they don't + +281 +00:21:28,350 --> 00:21:33,850 +consider the risk ما يهتموش بالضريبة they want to + +282 +00:21:33,850 --> 00:21:37,750 +avoid the high tax الناس اللي بيفضلوا الأرباح + +283 +00:21:37,750 --> 00:21:42,870 +المحتجزة طبعا في الحالة هذه هيتجنبوا دفع ضرائب + +284 +00:21:42,870 --> 00:21:48,920 +عالية فاحنا أمام two synergies the tax on the + +285 +00:21:48,920 --> 00:21:52,960 +dividends is higher than the capital gains الأرباح + +286 +00:21:52,960 --> 00:21:56,540 +الرأس مالية so some investors prefer the dividends + +287 +00:21:56,540 --> 00:22:02,340 +however it pay high tax other investors prefer the + +288 +00:22:02,340 --> 00:22:07,920 +capital gains and paying no tax طب التنين + +289 +00:22:07,920 --> 00:22:11,360 +بيه مشكلة على فكرة التنين إيه إيش بيه مشكلة مشكلة + +290 +00:22:11,360 --> 00:22:14,320 +هذا معروفة أنه بي .. أنه الضرائب طب مشكلة هذا وين؟ + +291 +00:22:16,580 --> 00:22:20,860 +time yes right the time إيش risk لأنه there is no + +292 +00:22:20,860 --> 00:22:24,320 +guarantee the price will go up فش ضمان الأسعار + +293 +00:22:24,320 --> 00:22:28,120 +ترتفع لفوق صحيح they are keeping the profits is + +294 +00:22:28,120 --> 00:22:31,180 +right they are keeping the profits but it is not + +295 +00:22:31,180 --> 00:22:35,300 +guaranteed the prices will go up يعني زي مثلا مثال + +296 +00:22:35,300 --> 00:22:38,800 +بنقول الحج والحجة اللي هو old man old man old lady + +297 +00:22:38,800 --> 00:22:43,880 +they consider one bird in your hand is more + +298 +00:22:43,880 --> 00:22:47,640 +preferable than ten birds on the tree يعني عصفور + +299 +00:22:47,640 --> 00:22:51,120 +بيدك أحسن من عشر على الشجرة ده ال thing in this way + +300 +00:22:51,120 --> 00:22:55,420 +بقى young people الناس الصغار في السن اللي زيكو + +301 +00:22:55,420 --> 00:23:00,240 +طبعا they have difference بيقولوا لأ why I don't + +302 +00:23:00,240 --> 00:23:03,240 +need money for instance now so خلي العشر على الشجرة + +303 +00:23:03,240 --> 00:23:07,640 +أحسن ما يكونوا في one bird in my hand because ten + +304 +00:23:07,640 --> 00:23:11,900 +birds on the tree .. ten birds on the tree إيش بيصير? ten + +305 +00:23:11,900 --> 00:23:17,650 +birds on the trees may call other bears to be in + +306 +00:23:17,650 --> 00:23:21,410 +the tree but if the bird is in your hands, no + +307 +00:23:21,410 --> 00:23:25,130 +additional birds will be in your hands يعني لما + +308 +00:23:25,130 --> 00:23:28,950 +تخلوا العشر على الشجرة, they calling more birds + +309 +00:23:28,950 --> 00:23:32,710 +هيستدعوا طيور أكثر تيجي على الشجرة لكن لما يكون + +310 +00:23:32,710 --> 00:23:37,610 +الطير بيدك في حد هييجي و that's it يعني + +311 +00:23:40,050 --> 00:23:44,630 +الفكرة هنا أنه ال capital gains is higher risk + +312 +00:23:44,630 --> 00:23:47,810 +than the dividends, the dividends is guaranteed, + +313 +00:23:48,130 --> 00:23:50,190 +there is a dividends, but the problem in the + +314 +00:23:50,190 --> 00:23:54,890 +dividends, there is high tax okay, so the + +315 +00:23:54,890 --> 00:23:57,590 +portfolios, the portfolio management is helping us + +316 +00:23:57,590 --> 00:24:00,790 +to state whether we prefer the tax or we avoid the + +317 +00:24:00,790 --> 00:24:04,990 +tax, some people or some investors are between the + +318 +00:24:04,990 --> 00:24:08,620 +two scenarios بعض الناس بال two scenarios ممكن + +319 +00:24:08,620 --> 00:24:12,080 +بياخدوا ال portfolios تبعتهم stocks بتعمل + +320 +00:24:12,080 --> 00:24:16,120 +dividends و stocks ما بتعملش dividends يعني بياخدوا أسهم + +321 +00:24:16,120 --> 00:24:19,280 +بتعمل dividends و أسهم ما بتعملش dividends هدول + +322 +00:24:19,280 --> 00:24:28,900 +بيكونوا إيش يعني متوسط المخاطر تمام؟ okay يعني لو + +323 +00:24:28,900 --> 00:24:34,600 +احنا قررنا مثلا ladies بال in her 35 to 40 ست كانت + +324 +00:24:34,600 --> 00:24:40,120 +من 35 لل40 مع راجل من 35 لل40 طبعا ال ladies عادة + +325 +00:24:40,120 --> 00:24:44,920 +بيكونوا يتحملوا المخاطر أقل فهم ممكن يختاروا + +326 +00:24:44,920 --> 00:24:49,360 +dividends مع capital gains ال mens تحملهم للمخاطر + +327 +00:24:49,360 --> 00:24:53,260 +أعلى شوية فممكن ان هم to go to the capital gains + +328 +00:24:53,260 --> 00:24:55,720 +إنهم يروحوا لل capital gains more than the + +329 +00:24:55,720 --> 00:25:01,350 +dividends okay هذا المثال ممكن احنا نعطيه طبعا هذا + +330 +00:25:01,350 --> 00:25:04,690 +ما يعني ان ال ladies they took whole dress لأ في + +331 +00:25:04,690 --> 00:25:08,610 +ناس ممكن يتحملوا بس احنا بنحكي in majority in the + +332 +00:25:08,610 --> 00:25:15,010 +majority اه بال majority يعني ان هم جداش بتحملوا + +333 +00:25:15,010 --> 00:25:19,290 +المخاطر ممكن رجال كمان conservative كونوا طبعا + +334 +00:25:19,290 --> 00:25:22,610 +احنا بنحكي بشكل عام إيش بيصير بالأسواق المالية + +335 +00:25:22,610 --> 00:25:23,470 +okay + +336 +00:25:31,000 --> 00:25:36,020 +طيب أي سؤال any question about the free + +337 +00:25:36,020 --> 00:25:39,200 +diversification appropriate risk level, tax + +338 +00:25:39,200 --> 00:25:45,200 +considerations؟ no questions؟ أه؟ في حد عنده سؤال؟ + +339 +00:25:45,200 --> 00:25:51,260 +okay طيب resource allocations توزيع الموارد أو + +340 +00:25:51,260 --> 00:25:52,780 +تخصيص الموارد + +341 +00:25:59,910 --> 00:26:02,270 +طيب ال market .. we still talking about the + +342 +00:26:02,270 --> 00:26:05,010 +implications of market efficiency احنا مازلنا + +343 +00:26:05,010 --> 00:26:08,230 +بنحكي عن أثر ال market efficiency on portfolio + +344 +00:26:08,230 --> 00:26:12,450 +management على إدارة المحفظة الاستثمارية if you + +345 +00:26:12,450 --> 00:26:16,490 +think the market is inefficient we cannot + +346 +00:26:16,490 --> 00:26:20,290 +efficiently allocate our resources يعني إذا احنا + +347 +00:26:20,290 --> 00:26:24,530 +بنعتقد أن السوق غير كفوء بيكون احنا من الصعوبة إن + +348 +00:26:24,530 --> 00:26:29,200 +احنا نعمل تخصيص الموارد تبعتنا because the market + +349 +00:26:29,200 --> 00:26:33,420 +is inefficient فبصير في miss pricing فبتكون الأسهم + +350 +00:26:33,420 --> 00:26:36,540 +الغالية هتكون رخيصة و الأسهم الرخيصة هتكون غالية + +351 +00:26:36,540 --> 00:26:41,260 +that's it يعني if the market is inefficient okay + +352 +00:26:42,550 --> 00:26:45,790 +فإذا كان السوق المالي كفوء يعني لو أجينا احنا مثلا + +353 +00:26:45,790 --> 00:26:48,870 +على ال mobile إذا كان السوق المالي كفوء هذا سعره + +354 +00:26:48,870 --> 00:26:51,610 +مثلا مائة دولار so the price is مائة دولار one + +355 +00:26:51,610 --> 00:26:55,430 +hundred dollar if the market is inefficient this + +356 +00:26:55,430 --> 00:26:59,610 +could be overpriced or could be underpriced ممكن + +357 +00:26:59,610 --> 00:27:02,570 +يكون أقل من سعره ممكن يكون أعلى من سعره يعني if + +358 +00:27:02,570 --> 00:27:04,730 +this one hundred dollar it could be one hundred + +359 +00:27:04,730 --> 00:27:07,510 +fifty if the market is inefficient and in this + +360 +00:27:07,510 --> 00:27:12,790 +case it is overpriced if it is fifty dollar it + +361 +00:27:12,790 --> 00:27:18,470 +means it is under priced and this is misleading if + +362 +00:27:18,470 --> 00:27:21,170 +the market is inefficient buying and selling these + +363 +00:27:21,170 --> 00:27:25,510 +mobile phones is misleading يعني ممكن تعمل + +364 +00:27:25,510 --> 00:27:31,310 +misleading يعني إيش misleading إنه ما يستطيعوش + +365 +00:27:31,310 --> 00:27:34,310 +ال investors to take the right decision okay + +366 +00:27:39,170 --> 00:27:42,450 +ف the implications of .. if markets were + +367 +00:27:42,450 --> 00:27:47,250 +inefficient إذا كان الأسواق ليست كفؤة resources + +368 +00:27:47,250 --> 00:27:51,810 +would be systematically misallocated هنروح نعمل + +369 +00:27:51,810 --> 00:27:54,670 +misallocation لل .. نروح .. نروح نستثمر في أشياء + +370 +00:27:54,670 --> 00:27:57,350 +غالية هي المفروض تكون رخيصة و أشياء رخيصة المفروض + +371 +00:27:57,350 --> 00:28:01,230 +تكون غالية so this is the things misallocation or + +372 +00:28:01,230 --> 00:28:05,010 +misleading as .. as I explained fame with + +373 +00:28:05,010 --> 00:28:07,310 +overvalued securities can raise capital too + +374 +00:28:07,310 --> 00:28:13,780 +cheaply يعني الشركات اللي أسعارها مغالا فيها ممكن + +375 +00:28:13,780 --> 00:28:20,560 +تحصل على تمويل رخيص و العكس شركات undervalued أقل + +376 +00:28:20,560 --> 00:28:25,280 +من قيمتها الحقيقية may have to pass up profitable + +377 +00:28:25,280 --> 00:28:27,700 +opportunities because the cost of capital is too high + +378 +00:28:27,700 --> 00:28:30,980 +ممكن أنه ما تحصلش على تمويل لأنه the cost of capital + +379 +00:28:30,980 --> 00:28:37,260 +تكلفة رأس المال بتكون عالية جدا okay so this is + +380 +00:28:37,260 --> 00:28:41,630 +important for resource allocation if the market is + +381 +00:28:41,630 --> 00:28:44,730 +efficient we can effectively allocate our + +382 +00:28:44,730 --> 00:28:49,170 +resources but the problem efficient market does + +383 +00:28:49,170 --> 00:28:53,230 +not mean perfect for sides markets ما بتعنيش كل شيء + +384 +00:28:53,230 --> 00:28:57,170 +تمام 100% هأعطيكم مثال يعني لا يعني أنه if the + +385 +00:28:57,170 --> 00:29:01,150 +market is efficient it means we have a proper + +386 +00:29:01,150 --> 00:29:05,970 +asset allocation ده يعني أنه السوق المالي كافٍ أنه + +387 +00:29:05,970 --> 00:29:11,150 +في عندنا توزيع صحيح for instance لو أنا جبت لكم car + +388 +00:29:11,150 --> 00:29:18,430 +2013 and we have two people سيارة 2013 efficient + +389 +00:29:18,430 --> 00:29:22,250 +خدنا نقول مثلاً لموزعين وجئنا the two people we have + +390 +00:29:22,250 --> 00:29:26,150 +a good driver and we have a bad driver and we said + +391 +00:29:26,150 --> 00:29:30,190 +to the bad driver take the keys and try it يعني + +392 +00:29:30,190 --> 00:29:33,290 +خذها المفاتيح وروح جربها maybe after one minute + +393 +00:29:33,290 --> 00:29:37,850 +come back with a smashed car ممكن بعد دقيقة يرجع لنا + +394 +00:29:37,850 --> 00:29:42,790 +والسيارة مكسرة and we may talk to the second + +395 +00:29:42,790 --> 00:29:45,750 +driver which is an excellent driver with a good + +396 +00:29:45,750 --> 00:29:50,170 +profile he can use it and get it back with + +397 +00:29:50,170 --> 00:29:54,260 +excellent condition لذا لدينا اتفاقين اثنين، + +398 +00:29:54,260 --> 00:29:59,760 +المشكلة في الناس وكيف يستخدموا المصادر، السيارة + +399 +00:29:59,760 --> 00:30:04,060 +مفيدة، كل شيء بخير، لكن المشكلة في الناس وكيف + +400 +00:30:04,060 --> 00:30:09,190 +يستخدموا المصادر you have good experience with a + +401 +00:30:09,190 --> 00:30:11,310 +good knowledge with the .. with the .. with a good + +402 +00:30:11,310 --> 00:30:14,650 +profile you can efficiently and effectively manage + +403 +00:30:14,650 --> 00:30:18,530 +the portfolios if you don't have this knowledge it + +404 +00:30:18,530 --> 00:30:22,990 +means you cannot do this هذه المشكلة efficient + +405 +00:30:22,990 --> 00:30:25,450 +market does not mean perfect foresight markets + +406 +00:30:25,450 --> 00:30:28,210 +because it depends on how people foresight how + +407 +00:30:28,210 --> 00:30:32,050 +they understand the portfolios يعني لو احنا جبنا + +408 +00:30:32,050 --> 00:30:36,190 +اللاب توب هذا وحكينا للناس خذوا صمموه لشغلات على + +409 +00:30:36,190 --> 00:30:41,340 +اللاب توب ممكن ناس بيعرفوه وناس ما بيعرفوش so it + +410 +00:30:41,340 --> 00:30:43,540 +depends يعني ما تفكروا أن والله احنا خدنا + +411 +00:30:43,540 --> 00:30:46,620 +portfolio management and investments and we can do + +412 +00:30:46,620 --> 00:30:51,440 +this so you should have skills to do the .. the + +413 +00:30:51,440 --> 00:30:57,020 +management .. the portfolio management okay نحكي + +414 +00:30:57,020 --> 00:31:02,410 +عن event studies اللقاء القادم بيكون نقف عند ال + +415 +00:31:02,410 --> 00:31:07,070 +event studies اللقاء القادم is the last meeting + +416 +00:31:07,070 --> 00:31:11,770 +talking about the chapter four diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/DzebllRyxXM_raw.json b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/DzebllRyxXM_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..306ef1db2917b63c1f0fc39b991d060e1afafa5e --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/DzebllRyxXM_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4519, "start": 21.09, "end": 45.19, "text": "بسم الله الرحمن الرحيم ال .. في ال previous meeting .. في ال previous meeting في اللقاءات الماضية كنا نحكي عن ال interest rates و ال effective rate of return و حكينا على الموضوع إن إذا كنا احنا بنحكي .. نحسب ال effective annual return", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 2423, 4386, 8978, 2423, 3894, 3440, 4386, 8978, 2423, 3894, 3440, 8978, 13672, 4587, 16606, 9307, 9673, 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"end": 965.69, "word": " استثمارية", "probability": 0.976171875}, {"start": 965.69, "end": 966.03, "word": " أخرى", "probability": 0.9680989583333334}, {"start": 966.03, "end": 966.65, "word": " بالتدخم", "probability": 0.878125}, {"start": 966.65, "end": 967.45, "word": " خلينا", "probability": 0.718017578125}, {"start": 967.45, "end": 967.77, "word": " نشوف", "probability": 0.9951171875}, {"start": 967.77, "end": 968.11, "word": " المثال", "probability": 0.9658203125}, {"start": 968.11, "end": 968.35, "word": " هذا", "probability": 0.6748046875}], "temperature": 1.0}, {"id": 36, "seek": 98914, "start": 969.3, "end": 989.14, "text": "شوفوا ال treasury bills انقرن ال treasury bills مع ال commercial paper احنا we sell commercial paper is one of the money market securities my question is which is hold higher risk او lower risk؟ مين بيحمل lower risk? treasury bills or commercial paper؟ commercial paper", "tokens": [8592, 38688, 14407, 2423, 47213, 12433, 16472, 4587, 2288, 1863, 2423, 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"probability": 0.98095703125}, {"start": 976.82, "end": 977.14, "word": " the", "probability": 0.927734375}, {"start": 977.14, "end": 978.56, "word": " money", "probability": 0.9375}, {"start": 978.56, "end": 978.82, "word": " market", "probability": 0.95703125}, {"start": 978.82, "end": 979.42, "word": " securities", "probability": 0.96923828125}, {"start": 979.42, "end": 981.0, "word": " my", "probability": 0.82470703125}, {"start": 981.0, "end": 981.34, "word": " question", "probability": 0.9345703125}, {"start": 981.34, "end": 981.62, "word": " is", "probability": 0.97119140625}, {"start": 981.62, "end": 981.98, "word": " which", "probability": 0.935546875}, {"start": 981.98, "end": 982.34, "word": " is", "probability": 0.6572265625}, {"start": 982.34, "end": 982.9, "word": " hold", "probability": 0.81982421875}, {"start": 982.9, "end": 983.84, "word": " higher", "probability": 0.71826171875}, {"start": 983.84, "end": 984.1, "word": " risk", "probability": 0.96728515625}, {"start": 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"word": " commercial", "probability": 0.63427734375}, {"start": 988.66, "end": 989.14, "word": " paper", "probability": 0.94775390625}], "temperature": 1.0}, {"id": 37, "seek": 101454, "start": 990.78, "end": 1014.54, "text": "إرادة my question like this yes treasury bills who's holding lower risk treasury bills okay so treasury bills holding lower risk fine yes okay يعني أقل مخاطر أقل مخاطر ال treasury bills بتحمل أقل مخاطر", "tokens": [28814, 2288, 18513, 3660, 452, 1168, 411, 341, 2086, 47213, 12433, 567, 311, 5061, 3126, 3148, 47213, 12433, 1392, 370, 47213, 12433, 5061, 3126, 3148, 2489, 2086, 1392, 37495, 22653, 5551, 4587, 1211, 3714, 9778, 41193, 2288, 5551, 4587, 1211, 3714, 9778, 41193, 2288, 2423, 47213, 12433, 39894, 35571, 1211, 5551, 4587, 1211, 3714, 9778, 41193, 2288], "avg_logprob": -0.27478448892461843, "compression_ratio": 1.6971830985915493, "no_speech_prob": 0.0, "words": [{"start": 990.78, "end": 991.3, "word": "إرادة", "probability": 0.716583251953125}, {"start": 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طبعا طبعا طبعا", "tokens": [9566, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995, 23032, 3555, 3615, 995], "avg_logprob": -0.11443452494485037, "compression_ratio": 11.095238095238095, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1015.72, "end": 1016.1, "word": "طبعا", "probability": 0.8555908203125}, {"start": 1016.1, "end": 1016.32, "word": " طبعا", "probability": 0.67236328125}, {"start": 1016.32, "end": 1016.66, "word": " طبعا", 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107258, "start": 1044.63, "end": 1072.59, "text": "the majority of the systematic risk انتبهوا لكلام اللي انا بحكي فيه the majority of systematic risk is inflation ايش يعني حكيته؟ the majority of systematic risk is inflation غالبية risk ايش ال systematic risk؟ مخاطر النظام هي تدخم يعني غالبية المخاطر النظامية هي تدخم يعني لو احنا لاحظنا هنا", "tokens": [3322, 6286, 295, 264, 27249, 3148, 16472, 2655, 3555, 3224, 14407, 5296, 28820, 10943, 13672, 1829, 1975, 8315, 4724, 5016, 4117, 1829, 8978, 3224, 264, 6286, 295, 27249, 3148, 307, 15860, 1975, 1829, 8592, 37495, 22653, 11331, 4117, 36081, 3224, 22807, 264, 6286, 295, 27249, 3148, 307, 15860, 32771, 6027, 3555, 10632, 3148, 1975, 1829, 8592, 2423, 27249, 3148, 22807, 3714, 9778, 41193, 2288, 28239, 19913, 10943, 39896, 6055, 3215, 9778, 2304, 37495, 22653, 32771, 6027, 3555, 10632, 9673, 9778, 41193, 2288, 28239, 19913, 10943, 10632, 39896, 6055, 3215, 9778, 2304, 37495, 22653, 45164, 1975, 5016, 8315, 20193, 5016, 19913, 8315, 34105], 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"text": "الغالبية المخاطر النظامية هي inflation تقريبا فوق 8% تقريبا 38% طيب نطلع على ال commercial paper نطلع على ال commercial paper ال commercial paper لنفترض ال return hand 5%", "tokens": [6027, 17082, 6027, 3555, 10632, 9673, 9778, 41193, 2288, 28239, 19913, 10943, 10632, 39896, 15860, 6055, 4587, 16572, 3555, 995, 6156, 30543, 1649, 4, 6055, 4587, 16572, 3555, 995, 12843, 4, 23032, 1829, 3555, 8717, 9566, 1211, 3615, 15844, 2423, 6841, 3035, 8717, 9566, 1211, 3615, 15844, 2423, 6841, 3035, 2423, 6841, 3035, 5296, 1863, 5172, 2655, 43042, 2423, 2736, 1011, 1025, 4], "avg_logprob": -0.22570801223628223, "compression_ratio": 1.6066666666666667, "no_speech_prob": 0.0, "words": [{"start": 1099.62, "end": 1100.34, "word": "الغالبية", "probability": 0.91162109375}, {"start": 1100.34, "end": 1103.08, "word": " المخاطر", "probability": 0.794677734375}, {"start": 1103.08, "end": 1103.46, "word": " النظامية", "probability": 0.9427490234375}, {"start": 1103.46, "end": 1103.64, "word": " هي", 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{"start": 1121.6, "end": 1122.26, "word": " return", "probability": 0.8564453125}, {"start": 1122.26, "end": 1122.66, "word": " hand", "probability": 0.2919921875}, {"start": 1122.66, "end": 1123.86, "word": " 5", "probability": 0.8037109375}, {"start": 1123.86, "end": 1124.36, "word": "%", "probability": 0.88037109375}], "temperature": 1.0}, {"id": 42, "seek": 115659, "start": 1127.64, "end": 1156.6, "text": "ال systematic risk او نحكي ال inflation زي ما بتكون ال systematic risk و ال inflation واحد ال inflation هي 3.1 بدنا نشوف to what extent the inflation influence on the commercial paper لأي درجة بتأثر ال systematic .. ال inflation بيأثر على ال commercial paper بنقول 3.1 divided by 5 اللي هو ال 5 5 percent جداش تطلع في النسبة المقوية؟", "tokens": [6027, 1185, 267, 299, 3148, 1975, 2407, 8717, 5016, 4117, 1829, 2423, 15860, 30767, 1829, 19446, 39894, 30544, 2423, 1185, 267, 299, 3148, 4032, 2423, 15860, 36764, 24401, 2423, 15860, 39896, 805, 13, 16, 47525, 8315, 8717, 8592, 38688, 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1.0}, {"id": 47, "seek": 130211, "start": 1273.4, "end": 1302.12, "text": "أو بنجوسانيه systematic risk because inflation is systematic risk on the influence of inflation or systematic risk on the treasury bills is higher than any other securities", "tokens": [10721, 2407, 44945, 7435, 41779, 7649, 1829, 3224, 1185, 267, 299, 3148, 570, 15860, 307, 27249, 3148, 322, 264, 6503, 295, 15860, 420, 27249, 3148, 322, 264, 47213, 12433, 307, 2946, 813, 604, 661, 38597], "avg_logprob": -0.3643663144773907, "compression_ratio": 1.464, "no_speech_prob": 0.0, "words": [{"start": 1273.4, "end": 1273.68, "word": "أو", "probability": 0.664794921875}, {"start": 1273.68, "end": 1274.38, "word": " بنجوسانيه", "probability": 0.5353597005208334}, {"start": 1274.38, "end": 1274.92, "word": " systematic", "probability": 0.50823974609375}, {"start": 1274.92, "end": 1275.12, "word": " risk", "probability": 0.95263671875}, {"start": 1275.12, "end": 1275.44, "word": " because", "probability": 0.4658203125}, {"start": 1275.44, "end": 1275.96, "word": " inflation", "probability": 0.6767578125}, {"start": 1275.96, "end": 1276.18, "word": " is", "probability": 0.91796875}, {"start": 1276.18, "end": 1276.56, "word": " systematic", "probability": 0.58740234375}, {"start": 1276.56, "end": 1277.18, "word": " risk", "probability": 0.9697265625}, {"start": 1277.18, "end": 1283.78, "word": " on", "probability": 0.6865234375}, {"start": 1283.78, "end": 1284.7, "word": " the", "probability": 0.8115234375}, {"start": 1284.7, "end": 1285.94, "word": " influence", "probability": 0.8251953125}, {"start": 1285.94, "end": 1286.58, "word": " of", "probability": 0.96533203125}, {"start": 1286.58, "end": 1288.18, "word": " inflation", "probability": 0.6474609375}, {"start": 1288.18, "end": 1288.4, "word": " or", "probability": 0.71337890625}, {"start": 1288.4, "end": 1288.7, "word": " systematic", "probability": 0.62353515625}, {"start": 1288.7, "end": 1289.1, "word": " risk", "probability": 0.9697265625}, {"start": 1289.1, "end": 1289.46, "word": " on", "probability": 0.8876953125}, {"start": 1289.46, "end": 1291.62, "word": " the", "probability": 0.87646484375}, {"start": 1291.62, "end": 1292.02, "word": " treasury", "probability": 0.939453125}, {"start": 1292.02, "end": 1292.5, "word": " bills", "probability": 0.84521484375}, {"start": 1292.5, "end": 1296.58, "word": " is", "probability": 0.93798828125}, {"start": 1296.58, "end": 1297.9, "word": " higher", "probability": 0.912109375}, {"start": 1297.9, "end": 1298.34, "word": " than", "probability": 0.966796875}, {"start": 1298.34, "end": 1301.32, "word": " any", "probability": 0.8916015625}, {"start": 1301.32, "end": 1301.58, "word": " other", "probability": 0.90087890625}, {"start": 1301.58, "end": 1302.12, "word": " securities", "probability": 0.9658203125}], "temperature": 1.0}, {"id": 48, "seek": 133091, "start": 1304.25, "end": 1330.91, "text": "any other securities زي ما إنتوا إحنا شايفين يعني أثر ال inflation على ال treasury bills أكثر من أثر ال inflation على أي security أخرى خليني أجرب ال derivatives مشتقات العقل بتاع المشتقات نفترض مثلا 70%", "tokens": [1325, 661, 38597, 30767, 1829, 19446, 11933, 29399, 14407, 11933, 5016, 8315, 13412, 995, 33911, 9957, 37495, 22653, 5551, 49115, 2423, 15860, 15844, 2423, 47213, 12433, 5551, 4117, 49115, 9154, 5551, 49115, 2423, 15860, 15844, 36632, 3825, 5551, 34740, 7578, 16490, 1211, 9957, 1829, 5551, 7435, 25513, 2423, 33733, 37893, 2655, 4587, 9307, 18863, 4587, 1211, 39894, 45761, 9673, 8592, 2655, 4587, 9307, 8717, 5172, 2655, 43042, 50113, 15040, 5285, 4], "avg_logprob": -0.22721354415019354, "compression_ratio": 1.544041450777202, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1304.25, "end": 1304.63, "word": "any", "probability": 0.3818359375}, {"start": 1304.63, "end": 1305.71, "word": " other", "probability": 0.892578125}, {"start": 1305.71, "end": 1307.03, "word": " securities", "probability": 0.91162109375}, {"start": 1307.03, "end": 1308.45, 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bills", "probability": 0.8125}, {"start": 1312.95, "end": 1313.97, "word": " أكثر", "probability": 0.9493815104166666}, {"start": 1313.97, "end": 1314.15, "word": " من", "probability": 0.9892578125}, {"start": 1314.15, "end": 1314.61, "word": " أثر", "probability": 0.965087890625}, {"start": 1314.61, "end": 1315.45, "word": " ال", "probability": 0.9765625}, {"start": 1315.45, "end": 1315.77, "word": " inflation", "probability": 0.8642578125}, {"start": 1315.77, "end": 1316.05, "word": " على", "probability": 0.826171875}, {"start": 1316.05, "end": 1316.43, "word": " أي", "probability": 0.81982421875}, {"start": 1316.43, "end": 1317.51, "word": " security", "probability": 0.95849609375}, {"start": 1317.51, "end": 1318.19, "word": " أخرى", "probability": 0.98681640625}, {"start": 1318.19, "end": 1318.63, "word": " خليني", "probability": 0.7724609375}, {"start": 1318.63, "end": 1319.01, "word": " أجرب", "probability": 0.8994140625}, {"start": 1319.01, "end": 1320.31, "word": " ال", "probability": 0.91943359375}, {"start": 1320.31, "end": 1320.71, "word": " derivatives", "probability": 0.95361328125}, {"start": 1320.71, "end": 1323.15, "word": " مشتقات", "probability": 0.743011474609375}, {"start": 1323.15, "end": 1326.47, "word": " العقل", "probability": 0.7311197916666666}, {"start": 1326.47, "end": 1326.69, "word": " بتاع", "probability": 0.790771484375}, {"start": 1326.69, "end": 1327.21, "word": " المشتقات", "probability": 0.97705078125}, {"start": 1327.21, "end": 1327.73, "word": " نفترض", "probability": 0.8505859375}, {"start": 1327.73, "end": 1328.95, "word": " مثلا", "probability": 0.869873046875}, {"start": 1328.95, "end": 1330.55, "word": " 70", "probability": 0.58447265625}, {"start": 1330.55, "end": 1330.91, "word": "%", "probability": 0.9169921875}], "temperature": 1.0}, {"id": 49, "seek": 135942, "start": 1334.02, "end": 1359.42, "text": "نقسم هان three point one اللي هى ال inflation divided by seventy كدهش بتطلع؟ three point one divided by seventy three point one divided by seventy اربعمية و اربعمية ماقول اربعمية يعني اربعمية او اربعمية", "tokens": [1863, 4587, 38251, 8032, 7649, 1045, 935, 472, 13672, 1829, 8032, 7578, 2423, 15860, 6666, 538, 25662, 9122, 3215, 3224, 8592, 39894, 9566, 1211, 3615, 22807, 1045, 935, 472, 6666, 538, 25662, 1045, 935, 472, 6666, 538, 25662, 1975, 25513, 25957, 10632, 4032, 1975, 25513, 25957, 10632, 19446, 39648, 1975, 25513, 25957, 10632, 37495, 22653, 1975, 25513, 25957, 10632, 1975, 2407, 1975, 25513, 25957, 10632], "avg_logprob": -0.3896780199173725, "compression_ratio": 1.889655172413793, "no_speech_prob": 0.0, "words": [{"start": 1334.02, "end": 1334.82, "word": "نقسم", "probability": 0.8421223958333334}, {"start": 1334.82, "end": 1335.62, "word": " هان", "probability": 0.6102294921875}, {"start": 1335.62, "end": 1336.14, "word": " three", "probability": 0.430419921875}, {"start": 1336.14, "end": 1337.08, "word": " point", "probability": 0.98388671875}, {"start": 1337.08, "end": 1337.34, 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" one", "probability": 0.95458984375}, {"start": 1346.82, "end": 1347.1, "word": " divided", "probability": 0.8798828125}, {"start": 1347.1, "end": 1347.36, "word": " by", "probability": 0.98828125}, {"start": 1347.36, "end": 1347.76, "word": " seventy", "probability": 0.892578125}, {"start": 1347.76, "end": 1353.08, "word": " three", "probability": 0.51025390625}, {"start": 1353.08, "end": 1353.36, "word": " point", "probability": 0.97705078125}, {"start": 1353.36, "end": 1353.62, "word": " one", "probability": 0.953125}, {"start": 1353.62, "end": 1353.98, "word": " divided", "probability": 0.90966796875}, {"start": 1353.98, "end": 1354.22, "word": " by", "probability": 0.98876953125}, {"start": 1354.22, "end": 1354.64, "word": " seventy", "probability": 0.90283203125}, {"start": 1354.64, "end": 1355.54, "word": " اربعمية", "probability": 0.64422607421875}, {"start": 1355.54, "end": 1355.78, "word": " و", "probability": 0.1937255859375}, {"start": 1355.78, "end": 1356.06, "word": " اربعمية", "probability": 0.75396728515625}, {"start": 1356.06, "end": 1356.7, "word": " ماقول", "probability": 0.30078125}, {"start": 1356.7, "end": 1357.86, "word": " اربعمية", "probability": 0.72564697265625}, {"start": 1357.86, "end": 1358.06, "word": " يعني", "probability": 0.802490234375}, {"start": 1358.06, "end": 1358.6, "word": " اربعمية", "probability": 0.8824462890625}, {"start": 1358.6, "end": 1358.94, "word": " او", "probability": 0.33154296875}, {"start": 1358.94, "end": 1359.42, "word": " اربعمية", "probability": 0.82763671875}], "temperature": 1.0}, {"id": 50, "seek": 138852, "start": 1361.12, "end": 1388.52, "text": "لأ three point one divided بس تلاتة فاصلة سبعة بتطلع zero zero something أكام zero عد؟ zero واحد أربعة و أربعين يعني بتأثر عليها ب أربعة point أربعة percent أربعة فاصلة أربعة في المية يعني بتأثر ال inflation على ال derivatives بس ب أربعة فاصلة أربعة في المية so we conclude that", "tokens": [1211, 10721, 1045, 935, 472, 6666, 4724, 3794, 6055, 1211, 9307, 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"word": " أربعة", "probability": 0.8216145833333334}, {"start": 1376.68, "end": 1377.14, "word": " percent", "probability": 0.96142578125}, {"start": 1377.14, "end": 1379.24, "word": " أربعة", "probability": 0.8785807291666666}, {"start": 1379.24, "end": 1379.5, "word": " فاصلة", "probability": 0.9534505208333334}, {"start": 1379.5, "end": 1379.72, "word": " أربعة", "probability": 0.9300130208333334}, {"start": 1379.72, "end": 1379.86, "word": " في", "probability": 0.37158203125}, {"start": 1379.86, "end": 1380.02, "word": " المية", "probability": 0.818359375}, {"start": 1380.02, "end": 1381.58, "word": " يعني", "probability": 0.73828125}, {"start": 1381.58, "end": 1382.06, "word": " بتأثر", "probability": 0.9493815104166666}, {"start": 1382.06, "end": 1382.18, "word": " ال", "probability": 0.95703125}, {"start": 1382.18, "end": 1382.7, "word": " inflation", "probability": 0.673828125}, {"start": 1382.7, "end": 1383.5, "word": " على", "probability": 0.66650390625}, {"start": 1383.5, 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"probability": 0.86572265625}], "temperature": 1.0}, {"id": 63, "seek": 174457, "start": 1715.27, "end": 1744.57, "text": "كل ما R .. ال real rate of return كل ما كان زائد زي ما انتوا شايفين بال chart هو على حال ال chart يعني لو انا هيك طلعت .. طلعت .. اه .. كيف؟ ال R ال real دايما بتكون تربيه معاها اللي هي .. معاها بال .. معاها بال .. بال total risk خدوا بالك بال total risk okay طيب خلصنا الملاحظات هذه", "tokens": [28820, 19446, 497, 4386, 2423, 957, 3314, 295, 2736, 28242, 19446, 25961, 30767, 16373, 3215, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 20666, 6927, 31439, 15844, 11331, 6027, 2423, 6927, 37495, 22653, 45164, 1975, 8315, 39896, 4117, 23032, 1211, 34268, 4386, 23032, 1211, 34268, 4386, 1975, 3224, 4386, 9122, 33911, 22807, 2423, 497, 2423, 957, 11778, 47302, 15042, 39894, 30544, 6055, 2288, 21292, 3224, 20449, 995, 11296, 13672, 1829, 39896, 4386, 20449, 995, 11296, 20666, 4386, 20449, 995, 11296, 20666, 4386, 20666, 3217, 3148, 16490, 3215, 14407, 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2116.63, "text": "بعد هيك صارت ان ال treasury bills طلعوا .. طلعوا النقطة هذه في ال 76 ال .. ال inflation زادت و ال treasury bills زادت ال treasury bills زادت و ال inflation زادت راحوا نزلوا مع بعض زي ما انتوا شايفين نزلوا مع بعض طلعوا مع بعض", "tokens": [3555, 22488, 39896, 4117, 20328, 9640, 2655, 16472, 2423, 47213, 12433, 23032, 1211, 3615, 14407, 4386, 23032, 1211, 3615, 14407, 28239, 47432, 3660, 29538, 8978, 2423, 24733, 2423, 4386, 2423, 15860, 30767, 18513, 2655, 4032, 2423, 47213, 12433, 30767, 18513, 2655, 2423, 47213, 12433, 30767, 18513, 2655, 4032, 2423, 15860, 30767, 18513, 2655, 12602, 39319, 14407, 8717, 11622, 1211, 14407, 20449, 45030, 11242, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 8717, 11622, 1211, 14407, 20449, 45030, 11242, 23032, 1211, 3615, 14407, 20449, 45030, 11242], "avg_logprob": -0.12881747700951315, "compression_ratio": 1.937142857142857, "no_speech_prob": 0.0, "words": [{"start": 2096.23, "end": 2096.57, "word": "بعد", 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00:00:42,740 +العلاقة بين ال return و ال risk تحطهم مع بعض بس ال + +6 +00:00:42,740 --> 00:00:46,420 +model تبع ال utility هو أخد بعين الاعتبار the risk + +7 +00:00:46,420 --> 00:00:49,960 +and return and the investors preferences أخد بعين + +8 +00:00:49,960 --> 00:00:53,120 +الاعتبار ال investors preferences يعني احنا ها لو + +9 +00:00:53,120 --> 00:00:56,780 +نيجي ال U اللي هو ال utility is equal to expected + +10 +00:00:56,780 --> 00:01:03,360 +rate of return العائد minus half of A A هنا هي ال + +11 +00:01:03,360 --> 00:01:10,070 +ايش ال risk aversion times sigma square مضروبة في + +12 +00:01:10,070 --> 00:01:14,310 +ال sigma square طبعا هذا sigma square ال sigma + +13 +00:01:14,310 --> 00:01:18,990 +square هنا هي ال risk ال A اللي هو ال risk + +14 +00:01:18,990 --> 00:01:25,090 +aversion okay E is expected rate of return and E + +15 +00:01:25,090 --> 00:01:28,750 +utility يعني بالأخير أنه احنا المنفعة بتساوي + +16 +00:01:28,750 --> 00:01:34,870 +بالعربي يعني الإيرادات نقص المخاطر طب المخاطر + +17 +00:01:34,870 --> 00:01:42,210 +مضروبة في تفضيل المخاطر تفضيل المخاطر okay هذا ال + +18 +00:01:42,210 --> 00:01:50,070 +utility functions طبقنا + +19 +00:01:50,070 --> 00:01:53,150 +المعادلة طبعا ان انتوا في البيت بترجعوا بتعيدوا + +20 +00:01:53,150 --> 00:01:57,250 +تطبيقها أخذنا بعين الاعتبار أن ال investor risk + +21 +00:01:57,250 --> 00:02:02,640 +aversion 2 أو تلاتة أو نص أو أربعة أو خمسة طبعا + +22 +00:02:02,640 --> 00:02:08,420 +اثنين بيكون بيفضل المخاطر خمسة تفضيل المخاطر أقل + +23 +00:02:08,420 --> 00:02:13,280 +okay العائد ال E of R زي ما أنتم شايفين هو سبعة + +24 +00:02:13,280 --> 00:02:18,740 +في المئة ناقص النص عارفينها والاثنين هي الاثنين ال + +25 +00:02:18,740 --> 00:02:24,220 +A و ال sigma تربيعها zero five لاحظنا أن كل ما + +26 +00:02:24,220 --> 00:02:29,340 +بتنخفض ال a كل ما بيزيد العقد طلعوا هان كل ما احنا + +27 +00:02:29,340 --> 00:02:33,580 +بنخفض ال a العقد بيزيد يعني كل ما الناس بت .. بتحب + +28 +00:02:33,580 --> 00:02:37,940 +المخاطر أكثر كل ما العقد بيزيد لو طلعنا هان + +29 +00:02:37,940 --> 00:02:41,440 +بتلاحظوا في ال .. في المنطقة هذه يعني اخترنا 13% + +30 +00:02:41,440 --> 00:02:46,860 +ال expected rate of return و minus half اثنين اللي + +31 +00:02:46,860 --> 00:02:51,360 +هو ال risk preference أو risk aversion ضرب اللي هو + +32 +00:02:51,360 --> 00:02:56,240 +عشرين في المئة squared بيطلع عندنا تسعة في المئة فلاحظوا + +33 +00:02:56,240 --> 00:03:00,400 +احنا لما كان اثنين كان العائد ال expected rate of + +34 +00:03:00,400 --> 00:03:04,410 +return هو تسعة في المئة لما صار خمسة صار expected + +35 +00:03:04,410 --> 00:03:07,670 +return تلاتة في المئة مع الكلام الفرق بين خمسة و + +36 +00:03:07,670 --> 00:03:10,110 +بين اثنين تقريبا تلات أرباع شوفوا تلاتة في المئة + +37 +00:03:10,110 --> 00:03:12,530 +تسعة في المئة تقريبا لو ضربنا تلاتة في المئة في + +38 +00:03:12,530 --> 00:03:16,610 +تلاتة بتطلع تسعة في المئة فكل ما احنا بنخفض ال + +39 +00:03:16,610 --> 00:03:24,530 +investor risk aversion كل ما ال utility بتزيد طيب + +40 +00:03:24,530 --> 00:03:29,350 +هذا ايش بفيدنا الكلام بفيدنا الكلام أنه احنا نعمل + +41 +00:03:29,350 --> 00:03:34,870 +portfolios نعمل محافظ استثمارية ايش معناه محافظ + +42 +00:03:34,870 --> 00:03:39,770 +استثمارية Portfolios لو احنا أخذنا investor عنده ألف + +43 +00:03:39,770 --> 00:03:45,710 +دولار one thousand dollar this + +44 +00:03:45,710 --> 00:03:48,730 +investor has option to invest in a particular + +45 +00:03:48,730 --> 00:03:51,250 +investor in investments يعني هذا المستثمر عنده + +46 +00:03:51,250 --> 00:03:56,390 +إمكانية يستثمرهم في individual investments في أيه؟ + +47 +00:03:56,390 --> 00:03:59,650 +خذوا + +48 +00:03:59,650 --> 00:04:00,070 +معناها + +49 +00:04:02,680 --> 00:04:06,600 +but the problem of this investor when he or she + +50 +00:04:06,600 --> 00:04:11,060 +invest in A he will hold 100% of the risk of A + +51 +00:04:11,060 --> 00:04:14,920 +يعني إذا بيستثمر في A هيتحمل مخاطر 100% تبعات A + +52 +00:04:14,920 --> 00:04:20,000 +from the portfolio management perspective من وجهة + +53 +00:04:20,000 --> 00:04:23,580 +نظر portfolio management المحافظ if you have 1000$ + +54 +00:04:23,580 --> 00:04:28,260 +you can invest them in many securities يعني ممكن + +55 +00:04:28,260 --> 00:04:33,800 +احنا نستثمرهم في A في B في C and D So in this case + +56 +00:04:33,800 --> 00:04:40,060 +في هذه الحالة investing one thousand dollar in + +57 +00:04:40,060 --> 00:04:45,560 +four different securities aims to increase return + +58 +00:04:45,560 --> 00:04:52,400 +الهدف منها increase return and + +59 +00:04:52,400 --> 00:04:55,760 +decrease risk + +60 +00:05:00,150 --> 00:05:02,950 +يعني هدف المحافظة الاستثمارية the main importance + +61 +00:05:02,950 --> 00:05:06,450 +or the main objective of managing the portfolios + +62 +00:05:06,450 --> 00:05:11,650 +is to increase return and to decrease risk let's + +63 +00:05:11,650 --> 00:05:18,130 +see how it works if you have portfolio A and B and + +64 +00:05:18,130 --> 00:05:21,790 +portfolio A dominates portfolio B يعني ايش معناه + +65 +00:05:21,790 --> 00:05:27,440 +dominates؟ dominates يعني أفضل أو أحسن من B إذا + +66 +00:05:27,440 --> 00:05:36,080 +قيمة إعادة A أكثر من قيمة إعادة B، وإذا قيمة A + +67 +00:05:36,080 --> 00:05:42,520 +أكثر من قيمة B، وإذا قيمة A أكثر من قيمة B، وإذا + +68 +00:05:42,520 --> 00:05:45,000 +قيمة A أكثر من قيمة B، وإذا قيمة A أكثر من قيمة B، + +69 +00:05:45,000 --> 00:05:49,600 +وإذا قيمة A أكثر من قيمة B، وإذا قيمة A أكثر من + +70 +00:05:49,600 --> 00:05:49,620 +قيمة B، وإذا قيمة A أكثر من قيمة B، وإذا قيمة A + +71 +00:05:49,620 --> 00:05:49,840 +أكثر من قيمة B، وإذا قيمة A أكثر من قيمة B، وإذا + +72 +00:05:49,840 --> 00:05:51,540 +قيمة A أكثر من قيمة B، وإذا قيمة A أكثر من قيمة B، + +73 +00:05:51,540 --> 00:05:58,550 +وإذا قيمة A أكثر من قالسبب يكون وجود المحافظة + +74 +00:05:58,550 --> 00:06:05,950 +الاستثمارية look at here look at this one we have + +75 +00:06:05,950 --> 00:06:18,850 +some stocks A,B,C,D,E and F بنعمل محافظة استثمارية + +76 +00:06:18,850 --> 00:06:21,350 +مثلا محافظة استثمارية we select B + +77 +00:06:27,140 --> 00:06:35,720 +D and E اخترناهم so what is the rate of return of + +78 +00:06:35,720 --> 00:06:39,940 +them ال + +79 +00:06:39,940 --> 00:06:45,140 +rate of return تبعهم for instance أنه يكون هذا ال + +80 +00:06:45,140 --> 00:06:48,440 +rate + +81 +00:06:48,440 --> 00:06:51,380 +of return يعني لو احنا جمعناهم مع بعض هيكون ال + +82 +00:06:51,380 --> 00:06:56,300 +rate of return like this هذا هو عدد الترجمة لأن عدد + +83 +00:06:56,300 --> 00:07:05,260 +الترجمة R بي هو عدد الوزن بي و عدد الوزن دي و عدد + +84 +00:07:05,260 --> 00:07:12,360 +الوزن إيه الوزن؟ + +85 +00:07:12,360 --> 00:07:19,910 +لكن سيجما بي ليس عادل، كون حذرا is not equal to the + +86 +00:07:19,910 --> 00:07:28,790 +w sigma a plus w sigma b plus w sigma c or cd here + +87 +00:07:28,790 --> 00:07:32,990 +this is right for the rate of return but it is not + +88 +00:07:32,990 --> 00:07:38,270 +right for the sigma for the risk إذا احنا شو صار + +89 +00:07:38,270 --> 00:07:42,190 +في العائد العائد زاد okay لما احنا بنعمل formula + +90 +00:07:42,190 --> 00:07:46,890 +لل portfolio في نفس الوقت لو احنا بدنا نستثمر في + +91 +00:07:46,890 --> 00:07:54,150 +any individual security عند هذا العائد عند هذه + +92 +00:07:54,150 --> 00:07:56,630 +النقطة من المخاطر المفروض نحصل على هذا العائد + +93 +00:07:56,630 --> 00:08:06,190 +مفروض بس احنا حصلنا على عائد أعلى okay طيب عند هذا + +94 +00:08:06,190 --> 00:08:12,250 +العائد المفروض يكون المخاطر تبعتي هيها المفروض هذه + +95 +00:08:12,250 --> 00:08:17,900 +المخاطر صح لسيادة فاحنا practically we reduce the + +96 +00:08:17,900 --> 00:08:22,780 +sigma, we reduce the risk and we increase the rate + +97 +00:08:22,780 --> 00:08:29,860 +of return okay I + +98 +00:08:29,860 --> 00:08:34,080 +said in the previous meeting when we talk about + +99 +00:08:34,080 --> 00:08:36,940 +utility + +100 +00:08:38,040 --> 00:08:42,140 +Listen here, utility is equal to the expected rate + +101 +00:08:42,140 --> 00:08:50,720 +of return minus half a sigma squared okay look at + +102 +00:08:50,720 --> 00:08:54,540 +here the expected return is we can estimate this + +103 +00:08:54,540 --> 00:08:57,200 +we can estimate the expected rate of return يعني + +104 +00:08:57,200 --> 00:09:01,220 +نقدر احنا نتوقع by using arithmetic and by using + +105 +00:09:01,220 --> 00:09:06,060 +geometric okay for half we know what it means half + +106 +00:09:06,060 --> 00:09:09,880 +ليش هي بالنص because if I said what is the + +107 +00:09:09,880 --> 00:09:13,900 +difference the space difference between me and and + +108 +00:09:13,900 --> 00:09:17,320 +her just half of the space يعني ايش الفرق بين + +109 +00:09:17,320 --> 00:09:21,820 +المسافة بينه وبينها يكون نص المسافة okay so it is + +110 +00:09:21,820 --> 00:09:27,020 +half a is the risk preferences or risk aversion + +111 +00:09:27,020 --> 00:09:33,580 +ايش risk aversion قدرش الناس بتتجنب المخاطر خليني + +112 +00:09:33,580 --> 00:09:39,260 +أعطيكم مثال risk aversion هذا بقسوة يعني بقدر أنا + +113 +00:09:39,260 --> 00:09:43,520 +أعطيكم questionnaire I give you questionnaire and + +114 +00:09:43,520 --> 00:09:46,320 +based on this questionnaire I can determine what + +115 +00:09:46,320 --> 00:09:49,440 +is the level of A بقدر أنا أحدد ال level of A + +116 +00:09:49,440 --> 00:09:54,260 +تبعكم يعني أعطيكم مثال بسيط لو احنا قلنا لكم أنكم + +117 +00:09:54,260 --> 00:09:57,620 +تروحوا على مطعم okay و هذا المطعم is the first + +118 +00:09:57,620 --> 00:10:01,570 +time to open in غزة و and this .. this restaurant + +119 +00:10:01,570 --> 00:10:07,090 +serve .. provide or service the chinese foods + +120 +00:10:07,090 --> 00:10:12,430 +بيقدم أيش؟ أكل صيني أكل صيني okay so you come in + +121 +00:10:12,430 --> 00:10:17,890 +and there is a menu وعطونا ال menu in this menu + +122 +00:10:17,890 --> 00:10:21,610 +because you are the first time most of the dishes + +123 +00:10:21,610 --> 00:10:27,700 +are chinese dishes أغلب ال dishes أيش؟ suddenly + +124 +00:10:27,700 --> 00:10:33,460 +your eyes come to the .. to some tradition dishes + +125 +00:10:33,460 --> 00:10:38,560 +يعني من ال foods you know يعني مثلا في كان عندكم + +126 +00:10:38,560 --> 00:10:42,900 +السوشي سمعتوا بالسوشي؟ مثلا كان فيه سوشي كان فيه + +127 +00:10:42,900 --> 00:10:49,920 +الـ calamar كان فيه كذا وفيه محطوم فلافل وحمص إيش + +128 +00:10:49,920 --> 00:10:55,370 +ممكن تختاروا؟ مين ممكن؟ أغلب الناس فتختار .. فإذا + +129 +00:10:55,370 --> 00:10:58,810 +اختارتوا الـ food اللي أنتم هتعرفوه فبتكون الـ a + +130 +00:10:58,810 --> 00:11:03,050 +تبعاتكم عالية كثير يعني أنه أنتم بتتجنبوا المخاطر + +131 +00:11:03,050 --> 00:11:09,290 +طبعا فبيصمموا questionnaire طيب هلأ كمان مثال + +132 +00:11:09,290 --> 00:11:13,770 +تشوفوا كمان مثال في نفس المطعم طبعا هذا بيعملوله + +133 +00:11:13,770 --> 00:11:19,620 +design عشان يشوفوا الـ investors إيش الـ a تبعاتهم في + +134 +00:11:19,620 --> 00:11:23,600 +الـ designs you are invited to the workshop and you + +135 +00:11:23,600 --> 00:11:26,940 +don't know anyone in the workshop تعرفيش أي واحد + +136 +00:11:26,940 --> 00:11:31,960 +بالـ workshop and in each table you should select + +137 +00:11:31,960 --> 00:11:37,680 +four people يعني لازم تختاروا أربع أشخاص تمام؟ + +138 +00:11:37,680 --> 00:11:42,440 +الأربع أشخاص some names okay some names you know + +139 +00:11:42,440 --> 00:11:47,100 +the names and these names are tradition to you يعني + +140 +00:11:47,100 --> 00:11:53,140 +مثلا في عندي واحد اسمه أحمد وواحد اسمه ويليام و + +141 +00:11:53,140 --> 00:11:58,760 +واحد اسمه شارب وواحد اسمه سوسان أو اسمها سوسان + +142 +00:11:58,760 --> 00:12:10,130 +وواحد اسمه مثلا مي Okay هذه الخمس أسماء هأقولك + +143 +00:12:10,130 --> 00:12:20,510 +اختاروا اختاروا على الـ table تبعتكم شخصيا الأغلب + +144 +00:12:20,510 --> 00:12:26,090 +هيختار أحمد لأنه هيعتبر أنه هو from the middle east + +145 +00:12:26,090 --> 00:12:29,670 +طبعا you don't know them ما بتعرفوش عنهم فتختاروا + +146 +00:12:29,670 --> 00:12:34,010 +أحمد واحتمال كثير هتختاروا سوسان لأنه is Arabic + +147 +00:12:34,010 --> 00:12:38,800 +names tradition names في بعض الناس is if you want + +148 +00:12:38,800 --> 00:12:42,880 +to take risk يعني في ناس هيختاروا أحمد و سوسان + +149 +00:12:42,880 --> 00:12:48,660 +نماي okay في ناس ممكن يختاروا ويليام وشارب إذا + +150 +00:12:48,660 --> 00:12:52,560 +اختارنا ويليام وشارب بيكون أنتم روحتوا على الـ + +151 +00:12:52,560 --> 00:12:55,820 +risk العالي لأنه بتكون تفكروا طب أنا كيف هأحكي + +152 +00:12:55,820 --> 00:12:59,580 +معاهم؟ كيف هأتكلم معاهم؟ إيش الكلام وش؟ طب ويمكن + +153 +00:12:59,580 --> 00:13:03,720 +هم بغير عننا وإيش؟ لكن some people they try to try + +154 +00:13:03,720 --> 00:13:07,960 +risk بعض الناس بدهم يحاولوا ياخدوا الـ risk إذا هي + +155 +00:13:07,960 --> 00:13:10,360 +الطريقة بيسموها بالـ questionnaire معطوط عندكم في + +156 +00:13:10,360 --> 00:13:14,000 +الكتاب some examples of this questionnaire في + +157 +00:13:14,000 --> 00:13:16,600 +الكتاب موجود عندكم مثال على الـ questionnaire so + +158 +00:13:16,600 --> 00:13:20,360 +using questionnaires other instrument in + +159 +00:13:20,360 --> 00:13:24,370 +estimating risk is a version observes individuals + +160 +00:13:24,370 --> 00:13:29,850 +decisions when confronted with risk يعني بقدر كده + +161 +00:13:29,850 --> 00:13:33,970 +المخاطر اللي ممكن يواجهوها الناس لما يواجهوا .. + +162 +00:13:33,970 --> 00:13:38,010 +كده .. لما يواجهوا المخاطر يا زي ما تشوفوهم مثلا + +163 +00:13:38,010 --> 00:13:40,890 +في برنامج فرنسي كنت أحضره يحطوا الأولاد الصغار في + +164 +00:13:40,890 --> 00:13:45,490 +مكان ويحطوهم under risk ويشوفوا how these kids + +165 +00:13:45,490 --> 00:13:49,810 +are behaving كيف هم بتصرفوا يعني مثلا أنه switch + +166 +00:13:49,810 --> 00:13:54,490 +the light يطفو الضوء وممكن يكون في some shadows + +167 +00:13:54,490 --> 00:13:58,770 +moving بعض الـ kids get scared ممكن يخافوا other + +168 +00:13:58,770 --> 00:14:02,290 +kids coming and to play with the shadows بعض + +169 +00:14:02,290 --> 00:14:05,010 +الأطفال هيروح يلعبوا معاهم وبالتالي this is + +170 +00:14:05,010 --> 00:14:11,610 +indication for the risk aversion الأولاد الصغار + +171 +00:14:11,610 --> 00:14:14,150 +they squeeze themselves in the corner الأولاد + +172 +00:14:14,150 --> 00:14:17,690 +الصغار اللي هم حطوا حالهم في الـ .. هده دول بجنب + +173 +00:14:17,690 --> 00:14:20,530 +المخاطر والولاد اللي راحوا هجموا وراحوا playing + +174 +00:14:20,530 --> 00:14:24,550 +with the shadows هدول بيكون عندهم risk preferences + +175 +00:14:25,740 --> 00:14:30,420 +يعني بيحطوهم في بيئة خطر، يعني مثلا في videos، + +176 +00:14:30,420 --> 00:14:32,340 +تطلع على الـ videos، keep .. concentrate in the + +177 +00:14:32,340 --> 00:14:35,980 +videos، something jumping، ف if you make your back + +178 +00:14:35,980 --> 00:14:38,740 +like this، get scared، مع الكلام فيه شوية مخاطر + +179 +00:14:38,740 --> 00:14:41,180 +عندك، some people they don't care، ممكن just + +180 +00:14:41,180 --> 00:14:44,780 +everything jumping and they don't .. okay؟ So this + +181 +00:14:44,780 --> 00:14:48,800 +is the .. some examples of the .. و الـ investment + +182 +00:14:48,800 --> 00:14:51,920 +banks they use these facilities بنوك الاستثمار + +183 +00:14:51,920 --> 00:14:54,220 +بيستخدموا هاي الـ facilities في عندهم special rooms + +184 +00:14:54,220 --> 00:14:57,880 +في عندهم computer system وبيجلس الواحد and they + +185 +00:14:57,880 --> 00:15:01,100 +.. they have many tools لأنهم بيعملوا أكثر من + +186 +00:15:01,100 --> 00:15:07,000 +system يعني أنا مرة أمام + +187 +00:15:07,000 --> 00:15:12,860 +شاشة في .. في أحد البنوك and some dots shows يعني + +188 +00:15:12,860 --> 00:15:16,160 +بتيجي مرة الـ dots بتظهر فما عليك اللي من حد ما تظهر + +189 +00:15:16,160 --> 00:15:20,400 +بتعمل click فاهمين كيف؟ فبيجي قوة الملاحظة عند + +190 +00:15:20,400 --> 00:15:26,820 +الواحد و something moving مثلا بيجي أسد بيطلع و + +191 +00:15:26,820 --> 00:15:32,240 +حمامة بيطلع فهو بيقولك صيد اللي أنت بدك إياه ففينا + +192 +00:15:32,240 --> 00:15:34,960 +إذا بيركزوا على الأسد بيكون عندهم الـ risk + +193 +00:15:34,960 --> 00:15:38,740 +preferences عالي إذا حد بيركز مثلا على الطير + +194 +00:15:38,740 --> 00:15:41,620 +البسيط بيكون الـ risk preferences تبعته عالية منخفضة + +195 +00:15:41,620 --> 00:15:45,000 +so it depends فهذه facilities كثير متوفرة في بنوك + +196 +00:15:45,000 --> 00:15:49,690 +الاستثمار عشان يتأكدوا من الـ a تبعتنا observe how + +197 +00:15:49,690 --> 00:15:53,950 +much people are willing to pay to avoid risk في + +198 +00:15:53,950 --> 00:15:57,230 +ناس لما يواجهوا مخاطر بدهم يتخلصوا من المخاطر يعني + +199 +00:15:57,230 --> 00:16:01,350 +مثلا أعطيكم مثال بسيط لو واحد ساكن وجاله جار + +200 +00:16:01,350 --> 00:16:07,970 +مزعج هذا الساكن ممكن أمامه حاليا يقولك okay don't + +201 +00:16:07,970 --> 00:16:13,170 +worry about this مش مهم فهذا is taking risk يقولك + +202 +00:16:13,170 --> 00:16:15,670 +يعني عند .. يعني عند ما يبدو يعمل مشكلة ما إحنا + +203 +00:16:15,670 --> 00:16:21,040 +بنعمله مشكلة كمان وقت ثاني بيشتغل مشاكل الزنا مطير + +204 +00:16:21,040 --> 00:16:26,760 +هيك، قال مش بدي فعل الشغلة ببيع البنز، فهو دفع عشان + +205 +00:16:26,760 --> 00:16:31,490 +إيش يتخلص من المخاطر Okay ف observe how much people + +206 +00:16:31,490 --> 00:16:34,510 +are willing to pay to avoid risk يعني في ناس ما + +207 +00:16:34,510 --> 00:16:37,490 +بيقدروش يتحملوا مخاطر وبالتالي هم بيدفعوا عشان أن + +208 +00:16:37,490 --> 00:16:40,270 +هم يتخلصوا من المخاطر فبنشوف الـ observe للـ people + +209 +00:16:40,270 --> 00:16:43,990 +هدول طبعا بنصممهم مثلا بعض الأسئلة إذا أنه أنت + +210 +00:16:43,990 --> 00:16:47,350 +مثلا صار معك إيه إيش ممكن تسوي إيش بتعمل okay so + +211 +00:16:47,350 --> 00:16:50,210 +these instruments are using to estimate risk + +212 +00:16:50,210 --> 00:16:54,460 +aversion capital allocation across risky and risk + +213 +00:16:54,460 --> 00:16:59,640 +-free portfolios لما إحنا بنكون محفظة محفظة + +214 +00:16:59,640 --> 00:17:09,060 +استثمارية المحفظة الاستثمارية هذه المفروض + +215 +00:17:09,060 --> 00:17:12,240 +بكونة من جزئين أساسيا الـ investors بحطوا في بعضهم + +216 +00:17:12,240 --> 00:17:15,420 +أنه ممكن تكون بكونة من risk from the two different + +217 +00:17:15,420 --> 00:17:20,780 +parts اللي هو risky assets and + +218 +00:17:20,780 --> 00:17:21,620 +risk-free assets + +219 +00:17:24,880 --> 00:17:29,160 +risk asset يعني أدوات استثمارية فيها مخاطر و risk + +220 +00:17:29,160 --> 00:17:32,640 +free assets أداة استثمارية ما فيش فيها مخاطر okay + +221 +00:17:32,640 --> 00:17:36,320 +it's a very important part of portfolio + +222 +00:17:36,320 --> 00:17:40,690 +construction لما إحنا بنبني محفظة استثمارية الـ asset + +223 +00:17:40,690 --> 00:17:43,770 +allocation التوزيع وتخصيص الموارد أهم خطوة إحنا + +224 +00:17:43,770 --> 00:17:47,490 +ممكن نعملها refers to the choice among broad asset + +225 +00:17:47,490 --> 00:17:50,670 +classes بدنا نراجع الـ asset classes اللي أخذناها + +226 +00:17:50,670 --> 00:17:53,650 +بشر طروات في عندنا money market instruments وفي + +227 +00:17:53,650 --> 00:17:55,450 +عندي capital market instruments في عندي treasury + +228 +00:17:55,450 --> 00:17:57,590 +bills في عندي commercial favors في عندي bonds في + +229 +00:17:57,590 --> 00:18:00,370 +عندي stocks في عندي everything so what's the + +230 +00:18:00,370 --> 00:18:04,730 +classes you are willing to put in your portfolio؟ + +231 +00:18:04,730 --> 00:18:06,630 +إيش هي الـ classes إيش هي الـ investments اللي أنت + +232 +00:18:06,630 --> 00:18:10,950 +هتحطها بالـ portfolio؟ controlling risk كيف إحنا + +233 +00:18:10,950 --> 00:18:15,590 +نسيطر على المخاطر simplest way هي أسهل طريقة من + +234 +00:18:15,590 --> 00:18:18,970 +you play the fractions of portfolio invested in + +235 +00:18:18,970 --> 00:18:21,730 +risky free assets versus the portion invested in + +236 +00:18:21,730 --> 00:18:25,310 +the risky assets أسهل طريقة إحنا ممكن نعملها أن + +237 +00:18:25,310 --> 00:18:29,590 +إحنا to use the fraction يعني مثلا شايفين risky + +238 +00:18:29,590 --> 00:18:35,330 +asset و risky free asset ممكن أنا أروح أستثمر في + +239 +00:18:35,330 --> 00:18:41,150 +لحظتين هيك أن أنا بالـ risk asset 30% وأنا 70% و + +240 +00:18:41,150 --> 00:18:47,190 +أحسب الـ ER وأحسب الـ Sigma كمان + +241 +00:18:47,190 --> 00:18:52,910 +بروح أعدل بدل ما هي 30 بروح آخد 50 50 وأحسب الـ ER + +242 +00:18:52,910 --> 00:18:58,690 +والـ Sigma P بدل 50 50 لأ بروح بزيد الـ asset اللي + +243 +00:18:58,690 --> 00:19:02,270 +فيها risk بخليها 60% وأنا 40% وبرضه بحسب كمان + +244 +00:19:02,270 --> 00:19:06,820 +بره What is the idea of this؟ إيش الفكرة من هذا + +245 +00:19:06,820 --> 00:19:10,140 +الموضوع؟ أنه أنا to reach what is the optimal + +246 +00:19:10,140 --> 00:19:18,600 +portfolio أحسن A أحسن R وأقل B يعني أنا عائد أقل + +247 +00:19:18,600 --> 00:19:24,120 +مخاطر هذا الهدف بضلني أغير في تركيبة المحفظة يعني + +248 +00:19:24,120 --> 00:19:30,040 +إذا ممكن أنا أبدأ مثلا risky assets و risk free + +249 +00:19:31,600 --> 00:19:35,240 +أبدأ صفر ومية في المية يعني إيه صفر يعني أنا + +250 +00:19:35,240 --> 00:19:40,660 +المحفظة تبعتي كلها risk free يعني خالية المخاطر + +251 +00:19:40,660 --> 00:19:45,460 +بعدين بزيد بقول عشرين جداش هتسين هان تمانين و بحسب + +252 +00:19:45,460 --> 00:19:50,140 +الـ expected return و بحسب الـ sigma طيب باجي + +253 +00:19:50,140 --> 00:19:54,760 +كمان بقول okay خلّي أربعين ستين طيب خلّي هن عشر + +254 +00:19:54,760 --> 00:19:59,040 +تمانين أو بنحكي خمسين خمسين fifty fifty طيب خلينا + +255 +00:19:59,040 --> 00:20:04,660 +نحكي هنا عن ستين أربعين okay خلينا نحكي كمان هنا + +256 +00:20:04,660 --> 00:20:09,480 +تمانين عشرين و بعدين خلينا نحكي مية صفر أخدنا most + +257 +00:20:09,480 --> 00:20:13,360 +of the possible portfolios أخدنا أغلب الاحتمالات + +258 +00:20:13,360 --> 00:20:16,960 +بعدين على الطرف الآخر نحسب الـ ER و نحسب الـ sigma + +259 +00:20:16,960 --> 00:20:22,000 +عند مواحفها تكون الـ ER تبعتها أعلى شيء و الـ sigma + +260 +00:20:22,000 --> 00:20:25,880 +أقل شيء بيقول this is the optimal portfolio عشان + +261 +00:20:25,880 --> 00:20:26,640 +ما نزعجكوش + +262 +00:20:29,000 --> 00:20:32,780 +بس أفهم عليك عشان ما نزعجكوش بنروح بنعمل فيه + +263 +00:20:32,780 --> 00:20:36,300 +معادلة بسيطة بنطبق المعادلة بتطلع لي what is the + +264 +00:20:36,300 --> 00:20:39,280 +optimal portfolio what is the optimal construction + +265 +00:20:39,280 --> 00:20:44,120 +يعني إيش أفضل تركيبة يعني إحنا .. هيك إحنا بنسوي + +266 +00:20:44,120 --> 00:20:48,840 +manual لكن لما إحنا بنعمل estimate أحسن تركيبة + +267 +00:20:48,840 --> 00:20:52,320 +لمحفظة الاستثمارية بدنا نستخدم المعادلة جايين نحكي + +268 +00:20:52,320 --> 00:21:02,260 +عن المعادلة ناخد مثال total market value 300 ألف + +269 +00:21:02,260 --> 00:21:05,780 +دولار إيش يعني total market value واحد معاه مبلغ + +270 +00:21:05,780 --> 00:21:13,660 +300 ألف دولار okay هدول بدو يستثمرهم اه هلا + +271 +00:21:13,660 --> 00:21:19,120 +هتفهميه total market value 300 ألف دولار يعني واحد + +272 +00:21:19,120 --> 00:21:26,600 +معاه 300 ألف دولار بدو يستثمرهم okay 300 ألف risk + +273 +00:21:26,600 --> 00:21:32,420 +free money market تسعين ألف تسعين + +274 +00:21:32,420 --> 00:21:40,040 +ألف إيش معلومة دول risk free okay طيب الـ fund + +275 +00:21:40,040 --> 00:21:44,880 +الباقي equities هي إيه equities طبعا هدول risk + +276 +00:21:44,880 --> 00:21:51,120 +free طبعا هذا هيكون إيش risky risk + +277 +00:21:51,120 --> 00:21:53,960 +free اللي هو money market instrument هي مكتوب risk + +278 +00:21:53,960 --> 00:22:00,680 +free تسعين ألف risk free الـ equities مية و تلتاش + +279 +00:22:00,680 --> 00:22:05,840 +أربعة مية الـ equities يعني إيه إيش؟ القاسهم equities + +280 +00:22:05,840 --> 00:22:13,020 +كده إيش استثمر فيهم؟ مية و تلتاش أربعة مية الـ bonds + +281 +00:22:13,020 --> 00:22:15,900 +استثمر في الـ bonds ستة وتسعين و ستمية + +282 +00:22:19,510 --> 00:22:22,150 +طيب، هلو لو إحنا جماعة ما جداش استثمر في الـ risk + +283 +00:22:22,150 --> 00:22:26,630 +مية و تلتاش و ستة و تسعة و ستمية بطلعوا متين و + +284 +00:22:26,630 --> 00:22:31,690 +عشرة طيب، جداش تركيبة المحفظة هذه؟ جداش نسبة الـ + +285 +00:22:31,690 --> 00:22:36,510 +risk free لـ الـ risk asset؟ بحسبها هو مستثمر تلاتمية + +286 +00:22:36,510 --> 00:22:45,670 +تسعين risk free و متين و عشرة okay متين و عشرة + +287 +00:22:45,670 --> 00:22:48,130 +risk asset جداش بطلع النسبة؟ + +288 +00:22:53,250 --> 00:23:03,650 +هنشوف الـ risk free تلاتين في المية okay و الثانية + +289 +00:23:03,650 --> 00:23:08,810 +سبعين + +290 +00:23:08,810 --> 00:23:13,030 +في المية هتكون طيب سبعين في المية طيب هلا نركز على + +291 +00:23:13,030 --> 00:23:18,260 +السبعين في المية هدول وزن الـ equity إحنا استثمرنا + +292 +00:23:18,260 --> 00:23:23,420 +بالـ equity 113 400 تكسيب على 210 بطلع استثمرنا 54% + +293 +00:23:23,420 --> 00:23:30,780 +من الـ portfolio 54% من الـ risk assets هي equity و + +294 +00:23:30,780 --> 00:23:37,320 +46% هي cash أي bonds okay + +295 +00:23:37,320 --> 00:23:38,460 +طيب + +296 +00:23:43,350 --> 00:23:48,750 +نيجي هذا، قولنا إحنا المحفظة هذه 30% ريسكي risk + +297 +00:23:48,750 --> 00:23:59,710 +-free و 70% كم ريسكي risk-asset إذا إحنا اعتبرنا + +298 +00:23:59,710 --> 00:24:08,530 +الـ risk-assets Y فبتكون هذه 1-Y، مظبوط؟ إذا + +299 +00:24:08,530 --> 00:24:14,360 +اعتبرنا هذه Y فبتكون هذه 1-Y Okay؟ زي ما أنتو + +300 +00:24:14,360 --> 00:24:21,820 +شايفين إحنا + +301 +00:24:21,820 --> 00:24:28,340 +مثال الفات خلينا نبعث الكلام هلا إحنا حكيناها + +302 +00:24:28,340 --> 00:24:36,740 +تلاتين في المية risk free كام؟ تسعين ألف صح؟ و هذه + +303 +00:24:36,740 --> 00:24:42,140 +تقريبا عندنا .. عندنا كام؟ + +304 +00:24:44,750 --> 00:24:50,910 +عنا مية و تلتاش equity وعنا ستة وتسعين ستة وتسعين + +305 +00:24:50,910 --> 00:24:59,230 +و ستمية bonds هدول اللي أنا بظللهم هدول risky اللي + +306 +00:24:59,230 --> 00:25:03,250 +هي بتشمل كام كلها بعضها سبعين في المية و هذه بتشمل + +307 +00:25:03,250 --> 00:25:07,750 +تلاتين في المية بس أنا الـ risky جسمتها باسمين bond + +308 +00:25:07,750 --> 00:25:17,120 +equity و bonds فإذا اعتبرنا هذه YY بتساوي 70 بتكون + +309 +00:25:17,120 --> 00:25:21,920 +واحد ناقص Y بتساوي 30 يعني إذا كانت Y سبع .. سبعين + +310 +00:25:21,920 --> 00:25:25,380 +بده تكون واحد ناقص Y، جداش؟ تلاتين، بدهاش يعني + +311 +00:25:25,380 --> 00:25:32,320 +علم، لأ؟ طيب، هيها Y بتين و عشرة، حجم الاستثمار + +312 +00:25:32,320 --> 00:25:35,680 +بتين و عشرة كله هذا، بتين و عشرة على تلاتمائة ألف + +313 +00:25:35,680 --> 00:25:40,160 +واحد ناقص Y له تسعين ألف على تلاتمائة ألف، مابدهاش + +314 +00:25:40,160 --> 00:25:46,890 +شيء كثير يعني نسبة الـ equity هي 37.8 من كل المحفظة + +315 +00:25:46,890 --> 00:25:53,370 +نسبة الـ bond 32.2 لو إحنا جمعنا هذه زائد هذه هتطلع + +316 +00:25:53,370 --> 00:25:59,310 +هذه الـ equity اجمعوا الـ equity مع الـ bonds هتطلع + +317 +00:25:59,310 --> 00:26:03,210 +هذه كلها the risk free assets بدا نحكي عن risk + +318 +00:26:03,210 --> 00:26:07,850 +free assets الـ risk free assets only the + +319 +00:26:07,850 --> 00:26:12,420 +government can issue default free bonds بس الحكومات + +320 +00:26:12,420 --> 00:26:19,840 +اللي بتصدر risk-free assets اللي هو أدوات مالية + +321 +00:26:19,840 --> 00:26:22,820 +خالية من المخاطر، طب إحنا عندنا في فلسطين، في + +322 +00:26:22,820 --> 00:26:25,560 +عندنا أدوات خالية خالية من المخاطر؟ + +323 +00:26:29,510 --> 00:26:32,830 +يعني هالـ .. لو اجينا إحنا سألنا سؤال بسيط أنت + +324 +00:26:32,830 --> 00:26:35,490 +أستاذ قاعد بتدرسنا على أمريكا و ما أمريكا و عملنا + +325 +00:26:35,490 --> 00:26:39,490 +دوشة في الموضوع طب إحنا بنكون محفظة استثمارية فيها + +326 +00:26:39,490 --> 00:26:47,770 +risk-free assets و فيها risk assets طب + +327 +00:26:47,770 --> 00:26:51,730 +عندنا سؤال عن كمية؟ ماعناش؟ أيوا .. هذا سؤال أنا + +328 +00:26:51,730 --> 00:26:56,560 +سألكوا في chapter one لما قلتلكم evaluate the + +329 +00:26:56,560 --> 00:27:00,180 +investment environment in Palestinian territories + +330 +00:27:00,180 --> 00:27:04,260 +إحنا فيه عندنا risk-free assets الـ risk-free + +331 +00:27:04,260 --> 00:27:08,260 +assets حسب سلطة النقد الفلسطينية بتحدد مثلا عندنا + +332 +00:27:08,260 --> 00:27:12,720 +سعر إعادة الخصم اللي بتحدد سلطة النقد الفلسطينية + +333 +00:27:12,720 --> 00:27:18,360 +هذا يعتبر risk-free في عندنا مثلا اللي هو نسبة + +334 +00:27:18,360 --> 00:27:21,640 +الاحتياط اللي بتفرض سلطة النقد على البنوك هذا + +335 +00:27:21,640 --> 00:27:24,880 +نسبة الاحتياط as a indicator لـ risk-free assets + +336 +00:27:26,460 --> 00:27:30,380 +Okay يعني ممكن نستخدم other approaches مش شرط انه + +337 +00:27:30,380 --> 00:27:34,400 +treasury bills يعني أقل إن في كل دولة من الدول هما + +338 +00:27:34,400 --> 00:27:40,520 +they know what is the risk free assets طيب فهذا + +339 +00:27:40,520 --> 00:27:46,800 +إجابتنا للسؤال portfolio + +340 +00:27:46,800 --> 00:27:49,800 +of one risk assets and risk free assets إذا كنا + +341 +00:27:49,800 --> 00:27:54,660 +نعمل محفظة استثمارية بتتكون من risk assets risk + +342 +00:27:54,660 --> 00:27:57,220 +assets و risk free assets it's possible to create + +343 +00:27:57,220 --> 00:27:59,920 +a complete portfolio by splitting investment funds + +344 +00:27:59,920 --> 00:28:05,700 +between safe and risky assets let's y portion + +345 +00:28:05,700 --> 00:28:09,500 +allocated the risky portfolio هذا شرحنا one minus + +346 +00:28:09,500 --> 00:28:13,440 +one one minus y portion to be invested in risky + +347 +00:28:13,440 --> 00:28:19,100 +free assets F يعني إحنا بدنا نعمل محفظة هذه نفسها + +348 +00:28:19,100 --> 00:28:25,000 +الـ one minus one نسميها F إيش يعني F؟ Risk-free و + +349 +00:28:25,000 --> 00:28:30,660 +الـ .. و الـ 70 هذه سميها B اللي هو Risk Assets okay + +350 +00:28:30,660 --> 00:28:36,620 +إيش بيصير معنى؟ بيصير معنى example using a chapter + +351 +00:28:36,620 --> 00:28:44,860 +ترجع لـ مثال في صفحة في .. في chapter 6.4 numbers + +352 +00:28:44,860 --> 00:28:50,400 +إذا كان عند الـ risk-free 7% risk + +353 +00:28:50,400 --> 00:28:58,910 +-free 7% و الـ sigma of risk free is zero انتبهوا يا + +354 +00:28:58,910 --> 00:29:09,530 +بنات هذا محطة أسئلة كتيرة الـ risk free لو + +355 +00:29:09,530 --> 00:29:16,230 +كان الـ risk free X يعني دي risk free X دي sigma of + +356 +00:29:16,230 --> 00:29:18,970 +risk free قداش هتساوي + +357 +00:29:23,900 --> 00:29:27,920 +العائد الخالي من المخاطر بيساوي X رقمه لأن X + +358 +00:29:27,920 --> 00:29:36,020 +بيساوي 8% سيجما F طيب + +359 +00:29:36,020 --> 00:29:42,340 +خليني أنا .. يا بابا انتبه هذا .. ارجع طلعوا هان + +360 +00:29:42,340 --> 00:29:47,180 +.. اه بالظبط طلعوا هان .. بنات فاتحولي بالكوا هان + +361 +00:29:47,180 --> 00:29:50,560 +الـ R هان تمانية في المية طب السيجما كده إيش مش قولنا + +362 +00:29:50,560 --> 00:29:51,800 +إحنا هي سيجما وهي ER + +363 +00:29:56,010 --> 00:30:06,330 +السيجما جداش؟ السيجما صفر سيجما صفر أي + +364 +00:30:06,330 --> 00:30:13,130 +نقطة موجودة هنا تساوي 9% ستكون السيجما high هاي + +365 +00:30:13,130 --> 00:30:21,450 +السيجما تحتها RF 7% سيجما RF 0% هذا السؤال سأسألكم + +366 +00:30:22,680 --> 00:30:27,240 +في الامتحان حصلت فيه هل + +367 +00:30:27,240 --> 00:30:32,460 +جيت بالفضاء يا بنات بالفضاء بالفضاء بتجاوبوا نيح + +368 +00:30:32,460 --> 00:30:36,620 +بس لما نيجي الامتحان لأنه إحنا انتبه بس أحكي على + +369 +00:30:36,620 --> 00:30:39,980 +الكلمتين شبابنا و بناتنا للأسف الشديد بيجروا ليلة + +370 +00:30:39,980 --> 00:30:45,640 +امتحانهم اللي بنجمعه بسرعة بننساه بسرعة فهد .. هد + +371 +00:30:45,640 --> 00:30:49,440 +مشكلتكم فأنا بنصحكم إن تقروا قبل الامتحان ترتبوا + +372 +00:30:49,440 --> 00:30:54,460 +حالكم تعملوا جدول إن يوم الامتحان أو قبل الامتحان + +373 +00:30:54,460 --> 00:31:01,160 +بيوم هي بس مراجعة بس يعني just Beijing طيب + +374 +00:31:01,160 --> 00:31:07,360 +الـ Rf 7% الـ Sigma Rf 0% + +375 +00:31:10,390 --> 00:31:18,970 +الـ Expected Rp 15%، الـ Sigma B 22%، الـ Y is a + +376 +00:31:18,970 --> 00:31:26,890 +percentage in B, Y1 is a percentage of RF مثلًا، + +377 +00:31:26,890 --> 00:31:29,890 +الـ expected return on the complete portfolio is + +378 +00:31:29,890 --> 00:31:32,770 +the risk-free rate plus the weight of B times the + +379 +00:31:32,770 --> 00:31:38,840 +risk premium طلع على المعادلة هنا الـ expected + +380 +00:31:38,840 --> 00:31:42,500 +return of the complete portfolio هذا الـ C complete + +381 +00:31:42,500 --> 00:31:48,480 +portfolio بتساوي الـ RF احنا عارفينها زائد الـ Y + +382 +00:31:48,480 --> 00:31:55,340 +times الـ Y طبعًا هنا الـ weight اللي احنا أخدناه + +383 +00:31:55,340 --> 00:31:56,440 +الوزن + +384 +00:32:03,240 --> 00:32:10,220 +بس احنا هو .. لما أنا بقول وزن الـ B يساوي Y ووزن + +385 +00:32:10,220 --> 00:32:15,960 +the weight of one minus Y is equal one minus Y or + +386 +00:32:15,960 --> 00:32:23,160 +F بس بدنا أحرف so RF plus Y طبعًا عارفين ARP minus + +387 +00:32:23,160 --> 00:32:28,540 +RF وبالتالي بتساوي الإجابة الـ complete portfolio + +388 +00:32:28,540 --> 00:32:30,060 +من الكلام اللي احنا خدناه + +389 +00:32:33,790 --> 00:32:38,870 +معطيات طبعًا اه هاي معطيات بعدين الـ complete + +390 +00:32:38,870 --> 00:32:45,850 +portfolio بيساوي 7 plus y 15-7 بس احنا عوضنا مش + +391 +00:32:45,850 --> 00:32:50,170 +أكثر طيب لسه نكمل المثال الـ risk of the complete + +392 +00:32:50,170 --> 00:32:53,110 +portfolio is ايش risk of complete portfolio؟ يعني + +393 +00:32:53,110 --> 00:32:57,670 +الـ sigma تنعد C الـ complete portfolio ايش بتشمل؟ + +394 +00:32:57,670 --> 00:33:06,750 +بتشمل الـ sigma الـ y والواحد minus y يعني الوزن تبع + +395 +00:33:06,750 --> 00:33:12,350 +الـ risk asset و الوزن تبع الـ risk free assets so + +396 +00:33:12,350 --> 00:33:14,430 +the risk of the complete portfolio is the weight + +397 +00:33:14,430 --> 00:33:22,910 +of B times the risk of B يعني sigma C يعني شوفوا + +398 +00:33:22,910 --> 00:33:29,650 +احنا ايش قلنا قلنا هذي sigma اللي هي الـ 1 minus Y + +399 +00:33:29,650 --> 00:33:37,150 +هذي sigma الـ Y هذه كلها مع بعضها شوفوا هذا بدا + +400 +00:33:37,150 --> 00:33:43,810 +أظللها بدا تكون sigma c اللي هي sigma c منطقيًا + +401 +00:33:43,810 --> 00:33:51,030 +هتساوي sigma y زائد sigma 1 minus y، مظبوط؟ هذا + +402 +00:33:51,030 --> 00:33:54,110 +بفصوء يعني أشرح لكم إياها يعني أنا لو دلت الأمور + +403 +00:33:54,110 --> 00:34:00,870 +بضل ماشي فيها طيب إذا احنا نعرف sigma 1y بتساوي + +404 +00:34:00,870 --> 00:34:06,050 +صفر، صح؟ لأن الـ sigma تبعت الـ risk free حكينا فيها + +405 +00:34:06,050 --> 00:34:10,730 +تساوي صفر طب إذا الـ sigma هذي تساوي صفر إذا sigma + +406 +00:34:10,730 --> 00:34:17,490 +C تساوي sigma B ايش + +407 +00:34:17,490 --> 00:34:23,870 +رأيك أنت شايفها هم طبعًا تساوي صفر إذا sigma C + +408 +00:34:23,870 --> 00:34:29,490 +بتساوي ايش و هذي رياضيات ايش احنا بس جيبنا هذي + +409 +00:34:29,490 --> 00:34:33,340 +تساوي صفر و روحنا عوضنا فيها مش أكثر sigma C بتساوي + +410 +00:34:33,340 --> 00:34:41,120 +سيجما B بجد + +411 +00:34:41,120 --> 00:34:45,840 +بنات فيها صعوبة هذه؟ هذه واضحة مافيها مشكلة يعني + +412 +00:34:45,840 --> 00:34:49,840 +احنا بس روح نهيها أنا قلت لكم الـ sigma تحت واحد + +413 +00:34:49,840 --> 00:34:54,980 +minus one سيجما تبعت risk free وهي تساوي صفر هذه + +414 +00:34:54,980 --> 00:34:59,820 +سيجما Y مابتساويش صفر بتساوي something هنا وبالتالي + +415 +00:34:59,820 --> 00:35:02,640 +الـ Complete Portfolio هذي كلها الـ Sigma C كلها + +416 +00:35:02,640 --> 00:35:11,140 +بتساوي Sigma B very simple okay يعني لو أنا بجيكم + +417 +00:35:11,140 --> 00:35:14,640 +في الامتحان بقولكم Sigma الـ expected return تبعها + +418 +00:35:14,640 --> 00:35:18,040 +سوى كذا و الـ expected يعني مثلًا لو قلنا الـ + +419 +00:35:18,040 --> 00:35:25,820 +expected return تبعت B بتساوي 7% و expected return + +420 +00:35:25,820 --> 00:35:35,790 +of and the RF is three percent وقلنا لكم sigma B + +421 +00:35:35,790 --> 00:35:44,270 +بتساوي one point two calculate sigma + +422 +00:35:44,270 --> 00:35:49,170 +C تفقد قبل ما تحكوا calculate sigma C تسعة وتسعون + +423 +00:35:49,170 --> 00:35:52,930 +في المياه بالبنات يا أستاذ قولهم اه طبعًا هذا خبرتي + +424 +00:35:52,930 --> 00:35:57,670 +مع الطلاب والطالبات مش ما تعطينا أنت sigma .. sigma + +425 +00:35:57,670 --> 00:36:03,390 +.. sigma F مش ما تعطينا إياها طب يعني أنا يعني + +426 +00:36:03,390 --> 00:36:07,170 +حاططكم هيك يعني السؤال طب أنا عارف إن أنا + +427 +00:36:07,170 --> 00:36:09,910 +ما أعطيكم .. مش ما أعطيكم إياها بعد الامتحان + +428 +00:36:09,910 --> 00:36:15,190 +هأقولكم إياها لأن sigma الـ B الـ one minus Y بتساوي + +429 +00:36:15,190 --> 00:36:19,130 +صفر فابدأ أقولكم إياها يعني ما هدياش assumption يعني + +430 +00:36:19,130 --> 00:36:24,150 +بدي هي لازم تعرفيها فهتكون الـ sigma C كده هتساوي + +431 +00:36:24,890 --> 00:36:31,830 +one point two بس هتكون واحد فاصلة اثنين لأنه قلنا + +432 +00:36:31,830 --> 00:36:46,310 +احنا sigma c بتساوي sigma b ايوه + +433 +00:36:46,310 --> 00:36:52,080 +ما هي احنا ها مش قلنا sigma c بتساوي sigma b طبعًا + +434 +00:36:52,080 --> 00:36:56,580 +لما احنا نجي نجي نقول له sigma C بتساوي اللي هو + +435 +00:36:56,580 --> 00:37:05,320 +one minus one times sigma بتاعة الـ F مظبوط plus Y + +436 +00:37:05,320 --> 00:37:13,440 +sigma بتاعة الـ C بتاعة الـ B مظبوط فهذه بتساوي تطلع + +437 +00:37:13,440 --> 00:37:21,000 +صفر فبتصير الـ sigma c بتساوي y sigma b لسه مكملناش + +438 +00:37:21,000 --> 00:37:25,260 +فاكرين لما قلت لكم و احنا لازم نطلع الـ y لما نطلع + +439 +00:37:25,260 --> 00:37:28,940 +الوزن ما بنعش نضل نجرب و نجرب في معادلة بتطلع الوزن + +440 +00:37:28,940 --> 00:37:33,860 +طب إذا y ايش هتساوي هنا من رياضية الثاني إعدادي + +441 +00:37:33,860 --> 00:37:37,600 +يعني + +442 +00:37:37,600 --> 00:37:43,040 +هي sigma c بتساوي y sigma b مظبوط من رياضية الثاني + +443 +00:37:43,040 --> 00:37:53,170 +إعدادي ايش هتساوي y هتساوي sigma c على sigma b طيب + +444 +00:37:53,170 --> 00:37:57,690 +إذا أنا معرف sigma c و بعرف sigma b y جداش هتكون + +445 +00:37:57,690 --> 00:38:02,270 +هاطلعها شوفتوا كيف احنا شوي شوي طلعنا لما وصلنا + +446 +00:38:02,270 --> 00:38:07,550 +لهذه الـ equation لأ + +447 +00:38:07,550 --> 00:38:13,430 +قصدي الاشتقاقات أنتم خليكوا على آخر شيء هذا لأ + +448 +00:38:13,430 --> 00:38:19,170 +لسه مخلصش طيب هذا الـ .. هذا بقى بيذكركن تبقوا بس + +449 +00:38:19,170 --> 00:38:25,330 +يلا اللي بيحذر هذا أنا بتعطيه خمس درجات هذه + +450 +00:38:25,330 --> 00:38:30,270 +المعادلة بقى بيذكركن لأ لأ في شغل احنا خدناها + +451 +00:38:30,270 --> 00:38:36,010 +شكلها طلعوا كيف هذه + +452 +00:38:36,010 --> 00:38:40,310 +الحرارة + +453 +00:38:40,310 --> 00:38:47,620 +ده اللي هتعرفوا طلعوا شكلها مش شكلها ايش اللي + +454 +00:38:47,620 --> 00:38:56,000 +فوق واللي تحت سمعتوا في شغلة اسمها مرة ما أنا + +455 +00:38:56,000 --> 00:39:03,120 +عارف سمعتوا في شغلة اسمها شار بريشو شار هذي شار + +456 +00:39:03,120 --> 00:39:06,700 +بريشو أصلًا شوفتوا وإن احنا بالأخير كلها الدوشة + +457 +00:39:06,700 --> 00:39:10,950 +وصلناها عشان نشتغل شار بريشو بن .. الـ slope هيساوي + +458 +00:39:10,950 --> 00:39:15,050 +expected return of P minus RF على sigma P بيطلع + +459 +00:39:15,050 --> 00:39:20,110 +ثمانية على اثنين وعشرين هذا المثال يا بنات بترجعوه + +460 +00:39:20,110 --> 00:39:25,030 +في الـ .. في الكتاب و .. و احنا هنعطيكم مشابه له + +461 +00:39:25,030 --> 00:39:29,650 +بالامتحان تمام؟ نوقف عند هذا الـ slides diff --git 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"text": "السبب يكون وجود المحافظة الاستثمارية look at here look at this one we have some stocks A,B,C,D,E and F بنعمل محافظة استثمارية مثلا محافظة استثمارية we select B", "tokens": [6027, 35457, 3555, 7251, 30544, 49610, 23328, 9673, 5016, 31845, 19913, 3660, 42963, 14851, 12984, 2304, 9640, 10632, 574, 412, 510, 574, 412, 341, 472, 321, 362, 512, 12966, 316, 11, 33, 11, 34, 11, 35, 11, 36, 293, 479, 44945, 25957, 1211, 3714, 5016, 31845, 19913, 3660, 44713, 12984, 2304, 9640, 10632, 50113, 15040, 3714, 5016, 31845, 19913, 3660, 44713, 12984, 2304, 9640, 10632, 321, 3048, 363], "avg_logprob": -0.15783514492753623, "compression_ratio": 1.4935064935064934, "no_speech_prob": 0.0, "words": [{"start": 356.67, "end": 357.15, "word": "السبب", "probability": 0.92138671875}, {"start": 357.15, "end": 357.55, "word": " يكون", "probability": 0.765625}, {"start": 357.55, "end": 358.09, "word": " وجود", "probability": 0.792724609375}, {"start": 358.09, "end": 358.55, "word": " المحافظة", 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"seek": 75565, "start": 727.55, "end": 755.65, "text": "Okay هذه الخمس أسماء هقولك اختاروا اختاروا على ال table تبعتكم شخصيا الأغلب هيختار أحمد لأنه هيعتبر ان هو from the middle east طبعا you don't know them مابتعرفوش عنهم فتختاروا أحمد واحتمال كتير هتختاروا Sawsam لأنه is Arabic names tradition names", "tokens": [8297, 29538, 33962, 2304, 3794, 5551, 38251, 16606, 8032, 39648, 4117, 1975, 46456, 9640, 14407, 1975, 46456, 9640, 14407, 15844, 2423, 3199, 6055, 3555, 34268, 24793, 13412, 9778, 9381, 25528, 16247, 17082, 46152, 39896, 46456, 9640, 5551, 35571, 3215, 5296, 33456, 3224, 39896, 34268, 26890, 16472, 31439, 490, 264, 2808, 10648, 23032, 3555, 3615, 995, 291, 500, 380, 458, 552, 3714, 16758, 2655, 3615, 28480, 2407, 8592, 18871, 16095, 6156, 2655, 46456, 9640, 14407, 5551, 35571, 3215, 36764, 33753, 2304, 6027, 9122, 2655, 13546, 8032, 2655, 46456, 9640, 14407, 318, 12282, 335, 5296, 33456, 3224, 307, 19938, 5288, 6994, 5288], "avg_logprob": -0.23576732319180327, 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instrument in estimating risk is a version", "tokens": [1211, 33456, 3224, 39894, 30544, 6055, 5172, 37983, 14407, 23032, 3555, 41850, 9122, 33911, 8032, 5016, 4117, 1829, 20449, 995, 16095, 22807, 9122, 33911, 8032, 2655, 4117, 19528, 20449, 995, 16095, 22807, 11933, 1829, 3224, 8592, 2423, 28820, 16758, 4032, 8592, 22807, 23032, 3555, 4032, 7251, 43020, 8032, 2304, 4724, 17082, 13546, 18871, 8315, 4032, 11933, 8592, 22807, 44381, 512, 561, 436, 853, 281, 853, 3148, 45030, 11242, 2423, 8315, 3794, 47525, 16095, 7251, 5016, 995, 12610, 14407, 7251, 47283, 3215, 14407, 2423, 3148, 11933, 15730, 8032, 47302, 41950, 16572, 28671, 4724, 1829, 38251, 2407, 11296, 20666, 44702, 20449, 2655, 2407, 9566, 43242, 24793, 8978, 33251, 2655, 16758, 512, 5110, 295, 341, 44702, 8978, 33251, 2655, 16758, 3714, 29245, 23328, 43242, 24793, 50113, 6027, 15844, 2423, 44702, 370, 1228, 1168, 49551, 661, 7198, 294, 8017, 990, 3148, 307, 257, 3037], "avg_logprob": -0.24224290399686665, "compression_ratio": 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1366.31, "word": " risk", "probability": 0.9521484375}, {"start": 1366.31, "end": 1366.67, "word": " asset", "probability": 0.91748046875}, {"start": 1366.67, "end": 1367.23, "word": " جداش", "probability": 0.921875}, {"start": 1367.23, "end": 1367.45, "word": " بطلع", "probability": 0.8804931640625}, {"start": 1367.45, "end": 1368.13, "word": " النسبة؟", "probability": 0.9732666015625}], "temperature": 1.0}, {"id": 53, "seek": 139413, "start": 1373.25, "end": 1394.13, "text": "هنشوف ال risk free تلاتين في المية okay والتانية سبعين في المية هتكون طيب سبعين في المية طيب هلا نركز على السبعين في المية هدول", "tokens": [3224, 1863, 8592, 38688, 2423, 3148, 1737, 6055, 1211, 9307, 9957, 8978, 9673, 10632, 1392, 16070, 2655, 7649, 10632, 8608, 3555, 3615, 9957, 8978, 9673, 10632, 8032, 2655, 30544, 23032, 1829, 3555, 8608, 3555, 3615, 9957, 8978, 9673, 10632, 23032, 1829, 3555, 8032, 15040, 8717, 31747, 11622, 15844, 21136, 3555, 3615, 9957, 8978, 9673, 10632, 8032, 3215, 12610], 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1638.36, "word": " نسبة", "probability": 0.9925130208333334}, {"start": 1638.36, "end": 1638.88, "word": " الاحتياط", "probability": 0.800537109375}, {"start": 1638.88, "end": 1639.02, "word": " اللي", "probability": 0.84228515625}, {"start": 1639.02, "end": 1639.28, "word": " بتفرض", "probability": 0.8821614583333334}, {"start": 1639.28, "end": 1639.6, "word": " سلطة", "probability": 0.8641357421875}, {"start": 1639.6, "end": 1639.84, "word": " النخدة", "probability": 0.9611002604166666}, {"start": 1639.84, "end": 1640.0, "word": " على", "probability": 0.8955078125}, {"start": 1640.0, "end": 1640.68, "word": " البنوك", "probability": 0.9576416015625}, {"start": 1640.68, "end": 1641.64, "word": " هذا", "probability": 0.87060546875}, {"start": 1641.64, "end": 1641.94, "word": " نسبة", "probability": 0.994140625}, {"start": 1641.94, "end": 1642.38, "word": " الاحتياط", "probability": 0.9454345703125}, {"start": 1642.38, "end": 1642.6, "word": " as", "probability": 0.64599609375}, 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"probability": 0.79150390625}, {"start": 1669.6, "end": 1669.8, "word": " كنا", "probability": 0.982666015625}, {"start": 1669.8, "end": 1670.1, "word": " نعمل", "probability": 0.9695638020833334}, {"start": 1670.1, "end": 1670.5, "word": " محفظة", "probability": 0.8353515625}, {"start": 1670.5, "end": 1671.18, "word": " استثمارية", "probability": 0.98662109375}, {"start": 1671.18, "end": 1671.82, "word": " بتتكون", "probability": 0.9275716145833334}, {"start": 1671.82, "end": 1672.06, "word": " من", "probability": 0.994140625}], "temperature": 1.0}, {"id": 64, "seek": 170144, "start": 1672.7, "end": 1701.44, "text": "risk assets risk assets و risk free assets it's possible to create a complete portfolio by splitting investment funds between safe and risky assets let's y portion allocated the risky portfolio هذا شرحنا one minus one one minus y portion to be invested in risky free assets F يعني احنا بدنا نعمل محفظة هذه نفسها ال one minus one نسميها F", "tokens": [33263, 9769, 3148, 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"الـ Expected Rp 15%، الـ Sigma B 22%، الـ Y is a percentage in B, Y1 is a percentage of RF مثلًا، الـ expected return on the complete portfolio is the risk-free rate plus the weight of B times the risk premium طلع على المعادلة هنا", "tokens": [6027, 39184, 2111, 10729, 497, 79, 2119, 4, 12399, 2423, 39184, 36595, 363, 5853, 4, 12399, 2423, 39184, 398, 307, 257, 9668, 294, 363, 11, 398, 16, 307, 257, 9668, 295, 26204, 50113, 1211, 14111, 995, 12399, 2423, 39184, 5176, 2736, 322, 264, 3566, 12583, 307, 264, 3148, 12, 10792, 3314, 1804, 264, 3364, 295, 363, 1413, 264, 3148, 12049, 23032, 1211, 3615, 15844, 9673, 3615, 18513, 37977, 34105], "avg_logprob": -0.3245535748345511, "compression_ratio": 1.3979057591623036, "no_speech_prob": 0.0, "words": [{"start": 1870.39, "end": 1870.65, "word": "الـ", "probability": 0.79638671875}, {"start": 1870.65, "end": 1871.05, "word": " Expected", "probability": 0.6546630859375}, {"start": 1871.05, "end": 1871.57, "word": " Rp", "probability": 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احنا عارفينها زائد ال Y times ال Y طبعا هان ال weight اللي احنا أخدناه الوزن", "tokens": [6027, 39184, 5176, 2736, 295, 264, 3566, 12583, 8032, 18513, 2423, 383, 3566, 12583, 39894, 3794, 995, 2407, 7578, 2423, 26204, 1975, 5016, 8315, 6225, 9640, 5172, 9957, 11296, 30767, 16373, 3215, 2423, 398, 1413, 2423, 398, 23032, 3555, 3615, 995, 8032, 7649, 2423, 3364, 13672, 1829, 1975, 5016, 8315, 5551, 9778, 3215, 8315, 3224, 2423, 2407, 11622, 1863], "avg_logprob": -0.28203125049670535, "compression_ratio": 1.4367088607594938, "no_speech_prob": 0.0, "words": [{"start": 1898.32, "end": 1898.52, "word": "الـ", "probability": 0.3314208984375}, {"start": 1898.52, "end": 1898.84, "word": " expected", "probability": 0.6591796875}, {"start": 1898.84, "end": 1899.22, "word": " return", "probability": 0.86083984375}, {"start": 1899.22, "end": 1899.42, "word": " of", "probability": 0.94970703125}, {"start": 1899.42, "end": 1899.56, "word": " the", "probability": 0.8486328125}, {"start": 1899.56, 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"probability": 0.951904296875}, {"start": 1949.26, "end": 1949.46, "word": " احنا", "probability": 0.8919270833333334}, {"start": 1949.46, "end": 1950.06, "word": " خدناه", "probability": 0.82208251953125}], "temperature": 1.0}, {"id": 74, "seek": 198257, "start": 1953.79, "end": 1982.57, "text": "معطيات طبعا اه هاي معطيات بعدين ال complete portfolio بيساوي 7 plus y 15-7 بس احنا عوضنا مش اكتر طيب لسه نكمل المثال ال risk of the complete portfolio is ايش risk of complete portfolio؟ يعني ال sigma تنعد c ال complete portfolio ايش بتشمل؟ بتشمل ال sigma ال y والواحد minus y", "tokens": [2304, 3615, 9566, 1829, 9307, 23032, 3555, 3615, 995, 1975, 3224, 8032, 47302, 20449, 9566, 1829, 9307, 39182, 9957, 2423, 3566, 12583, 4724, 1829, 3794, 995, 45865, 1614, 1804, 288, 2119, 12, 22, 4724, 3794, 1975, 5016, 8315, 6225, 2407, 11242, 8315, 37893, 1975, 4117, 2655, 2288, 23032, 1829, 3555, 5296, 3794, 3224, 8717, 24793, 1211, 9673, 12984, 6027, 2423, 3148, 295, 264, 3566, 12583, 307, 1975, 1829, 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portfolio", "probability": 0.99169921875}, {"start": 1976.57, "end": 1976.73, "word": " ايش", "probability": 0.8748372395833334}, {"start": 1976.73, "end": 1977.67, "word": " بتشمل؟", "probability": 0.93505859375}, {"start": 1977.67, "end": 1978.23, "word": " بتشمل", "probability": 0.9793294270833334}, {"start": 1978.23, "end": 1978.89, "word": " ال", "probability": 0.86181640625}, {"start": 1978.89, "end": 1979.23, "word": " sigma", "probability": 0.92822265625}, {"start": 1979.23, "end": 1979.93, "word": " ال", "probability": 0.89013671875}, {"start": 1979.93, "end": 1980.67, "word": " y", "probability": 0.689453125}, {"start": 1980.67, "end": 1981.89, "word": " والواحد", "probability": 0.6685384114583334}, {"start": 1981.89, "end": 1982.19, "word": " minus", "probability": 0.955078125}, {"start": 1982.19, "end": 1982.57, "word": " y", "probability": 0.9462890625}], "temperature": 1.0}, {"id": 75, "seek": 201287, "start": 1984.55, "end": 2012.87, "text": "يعني الوزن تبع ال risk asset و الوزن تبع ال risk free assets so the risk of the complete portfolio is the weight of B times the risk of B يعني sigma C يعني شوفوا احنا ايش قلنا قلنا هذي sigma اللي هي ال 1 minus Y هذي sigma ال Y", "tokens": [40228, 22653, 2423, 2407, 11622, 1863, 6055, 3555, 3615, 2423, 3148, 11999, 4032, 2423, 2407, 11622, 1863, 6055, 3555, 3615, 2423, 3148, 1737, 9769, 370, 264, 3148, 295, 264, 3566, 12583, 307, 264, 3364, 295, 363, 1413, 264, 3148, 295, 363, 37495, 22653, 12771, 383, 37495, 22653, 13412, 38688, 14407, 1975, 5016, 8315, 1975, 1829, 8592, 12174, 1211, 8315, 12174, 1211, 8315, 8032, 8848, 1829, 12771, 13672, 1829, 39896, 2423, 502, 3175, 398, 8032, 8848, 1829, 12771, 2423, 398], "avg_logprob": -0.21132812108844518, "compression_ratio": 1.7151162790697674, "no_speech_prob": 0.0, "words": [{"start": 1984.55, "end": 1984.83, "word": "يعني", "probability": 0.893798828125}, {"start": 1984.83, "end": 1985.33, "word": " الوزن", "probability": 0.9876708984375}, {"start": 1985.33, "end": 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"end": 2115.04, "word": " سوى", "probability": 0.6759440104166666}, {"start": 2115.04, "end": 2115.44, "word": " كذا", "probability": 0.923583984375}, {"start": 2115.44, "end": 2115.96, "word": " و", "probability": 0.350341796875}, {"start": 2115.96, "end": 2116.02, "word": " ال", "probability": 0.607421875}, {"start": 2116.02, "end": 2116.36, "word": " expected", "probability": 0.81884765625}, {"start": 2116.36, "end": 2116.92, "word": " يعني", "probability": 0.725341796875}, {"start": 2116.92, "end": 2117.24, "word": " مثلا", "probability": 0.977783203125}, {"start": 2117.24, "end": 2117.74, "word": " لو", "probability": 0.84619140625}, {"start": 2117.74, "end": 2117.94, "word": " قلنا", "probability": 0.8445638020833334}, {"start": 2117.94, "end": 2118.04, "word": " ال", "probability": 0.888671875}, {"start": 2118.04, "end": 2118.4, "word": " expected", "probability": 0.89501953125}, {"start": 2118.4, "end": 2118.94, "word": " return", "probability": 0.9404296875}, {"start": 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مع الطلاب و الطالبان", "tokens": [474, 264, 26204, 307, 1045, 3043, 4032, 4587, 1211, 8315, 5296, 4117, 14407, 12771, 363, 39894, 3794, 995, 45865, 472, 935, 732, 8873, 12771, 383, 6055, 5172, 28543, 12174, 36150, 19446, 6055, 5016, 4117, 14407, 8873, 12771, 383, 6055, 3794, 27884, 34683, 3794, 3615, 9957, 8978, 9673, 25528, 3224, 20666, 3555, 8315, 2655, 35186, 5551, 14851, 45636, 12174, 12610, 16095, 1975, 3224, 23032, 3555, 3615, 995, 23758, 16490, 26890, 31371, 20449, 41950, 15040, 3555, 4032, 41950, 6027, 3555, 7649], "avg_logprob": -0.26250001303851606, "compression_ratio": 1.51, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2128.19, "end": 2128.51, "word": "and", "probability": 0.603515625}, {"start": 2128.51, "end": 2128.65, "word": " the", "probability": 0.8681640625}, {"start": 2128.65, "end": 2129.09, "word": " RF", "probability": 0.71240234375}, {"start": 2129.09, "end": 2131.67, "word": " is", "probability": 0.9052734375}, {"start": 2131.67, "end": 2132.23, 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الـ bond market بالأسواق + +3 +00:00:33,280 --> 00:00:38,710 +السندات، قسمنا أسواق السندات الـ bond market لـ + +4 +00:00:38,710 --> 00:00:46,710 +government bonds و corporate bonds، اليوم هنحكي بالـ + +5 +00:00:46,710 --> 00:00:54,430 +equity securities، هنحكي بالأسواق الأسهم أو أسواق + +6 +00:00:54,430 --> 00:01:01,310 +الأسهم العادية و الممتازة، فانتبهوا معنا، الـ equity + +7 +00:01:01,310 --> 00:01:05,010 +securities includes the common stock and preferred + +8 +00:01:05,010 --> 00:01:11,610 +stock، نحكي هنا عن equity، equity + +9 +00:01:11,610 --> 00:01:19,130 +market includes common stock and preferred stock، + +10 +00:01:19,130 --> 00:01:22,650 +بتشمل + +11 +00:01:22,650 --> 00:01:26,450 +نوعية من الأسهم، الأسهم العادية و الأسهم الممتازة، + +12 +00:01:26,450 --> 00:01:32,560 +نحكي، نبدأ بالـ common stock، نبدأ بالأسهم العادية الـ + +13 +00:01:32,560 --> 00:01:38,060 +.. الـ common stock is represent the ownership of + +14 +00:01:38,060 --> 00:01:43,560 +the investors in a particular company، يعني بتمثل + +15 +00:01:43,560 --> 00:01:49,200 +ملكية المستثمرين أو المساهمين في الشركة، + +16 +00:01:51,580 --> 00:01:53,280 +there are some characteristics on the common + +17 +00:01:53,280 --> 00:01:58,220 +stock، بعض الخصائص للـ common stock and there are + +18 +00:01:58,220 --> 00:02:00,440 +some general characteristics for the common stock، + +19 +00:02:00,440 --> 00:02:03,760 +في بعض الخصائص العامة للـ common stock مثل الـ + +20 +00:02:03,760 --> 00:02:09,770 +voting right، زي ما أنتو بتعرفوا، voting right، حق + +21 +00:02:09,770 --> 00:02:18,630 +التصويت، for each stockholder has right to vote to + +22 +00:02:18,630 --> 00:02:22,190 +select the board of directors، كل واحد من الـ + +23 +00:02:22,190 --> 00:02:28,470 +shareholder أو الـ stockholder له حق يصوت لاختيار + +24 +00:02:28,470 --> 00:02:32,070 +مجلس الإدارة، يعني voting to select the board of + +25 +00:02:32,070 --> 00:02:36,610 +directors، this is BOD، stand for the board of + +26 +00:02:36,610 --> 00:02:41,410 +directors، then the .. then the board of directors + +27 +00:02:41,410 --> 00:02:48,890 +select the .. the managers، business managers، the + +28 +00:02:48,890 --> 00:02:52,430 +managers are in charge to run the .. the daily + +29 +00:02:52,430 --> 00:02:55,590 +business activities، و المدراء هم المسئولين عشان + +30 +00:02:55,590 --> 00:03:02,590 +ليديروا أعمال و الأنشطة اليومية للمنشأة، الـ voting + +31 +00:03:02,590 --> 00:03:06,430 +rights هاي is general characteristics، خاصية عامة للـ + +32 +00:03:06,430 --> 00:03:09,250 +.. للـ common stocks، however there are some stocks + +33 +00:03:09,250 --> 00:03:13,690 +has no voting rights، في بعض الخصي .. I'm not + +34 +00:03:13,690 --> 00:03:16,090 +talking about the preferred stock، there are some + +35 +00:03:16,090 --> 00:03:20,750 +common stock، في بعض الـ common stock they don't + +36 +00:03:20,750 --> 00:03:26,930 +have the .. the voting rights، because some + +37 +00:03:26,930 --> 00:03:31,650 +companies issue some private issues for the common + +38 +00:03:31,650 --> 00:03:35,070 +stock، يعني بعض المؤسسات، بعض الشركات تصدر أسهم + +39 +00:03:35,070 --> 00:03:40,490 +عادية لا تتمتع بحق التصويت وهي في special + +40 +00:03:40,490 --> 00:03:43,850 +condition to issue this، but generally بشكل عام + +41 +00:03:43,850 --> 00:03:47,050 +الأسهم العادية هي لها حق التصويت، but in some cases + +42 +00:03:47,050 --> 00:03:50,090 +in some special cases، they some companies have a + +43 +00:03:50,090 --> 00:03:53,590 +right to issue shares with no voting rights، يعني + +44 +00:03:53,590 --> 00:03:56,890 +بعض المؤسسة، as you .. if you just read in the + +45 +00:03:56,890 --> 00:04:02,970 +footnotes، you will read some corporates may issue + +46 +00:04:02,970 --> 00:04:06,790 +stock or common stock، they don't have voting + +47 +00:04:06,790 --> 00:04:12,710 +rights، ما عندهمش حق التصويت، there's some specific + +48 +00:04:12,710 --> 00:04:15,330 +characteristics for the common stocks، في بعض + +49 +00:04:15,330 --> 00:04:19,170 +الخصائص المحددة للـ common stocks، for instance the + +50 +00:04:19,170 --> 00:04:23,360 +first one is the residual claim، residual claim، + +51 +00:04:23,360 --> 00:04:30,220 +residual claim، it means the common stockholder has + +52 +00:04:30,220 --> 00:04:35,440 +the last in line for the claim when the company go + +53 +00:04:35,440 --> 00:04:39,700 +to the bankruptcy، يعني آخر ناس بيستطيعوا يحصلوا + +54 +00:04:39,700 --> 00:04:44,080 +على حقوقهم وعلى أموالهم، هم أصحاب الأسهم العادية، + +55 +00:04:44,880 --> 00:04:48,220 +فبسموها residual claim، يعني آخر ناس بيحصلوا على + +56 +00:04:48,220 --> 00:04:53,760 +مستحقاتهم واستثماراتهم، هم أصحاب الأسهم العادية، + +57 +00:04:53,760 --> 00:04:57,000 +this is why they call them residual claim، عشان هيك + +58 +00:04:57,000 --> 00:05:00,840 +بيسموهم residual، residual يعني المتبقي، يعني بعد ما + +59 +00:05:00,840 --> 00:05:04,120 +.. لما يصير bankruptcy، bankruptcy معناها إفلاس، + +60 +00:05:04,120 --> 00:05:09,790 +they rank the investors according to their priority، + +61 +00:05:09,790 --> 00:05:12,110 +and they apply some rules and regulations to rank + +62 +00:05:12,110 --> 00:05:16,470 +them، يعني حسب القوانين، لما الشركة تروح للإفلاس، + +63 +00:05:16,470 --> 00:05:21,650 +بيروحوا بيرتبوا المستثمرين، مثلا الديون، الديون كانت + +64 +00:05:21,650 --> 00:05:25,210 +للحكومة، إذا الديون كانت لشركات، إذا كان ضريبة، إذا + +65 +00:05:25,210 --> 00:05:28,650 +كان رواتب موظفين، كلهم بيرتبوهم حسب الأولوية، + +66 +00:05:28,650 --> 00:05:32,810 +والقانون هو اللي بيرتب الأولوية، الـ common stock + +67 +00:05:32,810 --> 00:05:37,360 +بتاخد the last priority، الـ commerce للأسهم العادية + +68 +00:05:37,360 --> 00:05:42,320 +بتاخد آخر، آخر إشي، فبعد ما يصير bankruptcy، يروح + +69 +00:05:42,320 --> 00:05:45,420 +يوزع كل واحد مستحقاته، المتبقي هذا بيسموه residual، + +70 +00:05:45,420 --> 00:05:51,080 +المتبقي بيعتول الأسهم العادية، هذا إذا ضال متبقي، + +71 +00:05:51,080 --> 00:05:57,280 +limited liability، limited liability، it means the + +72 +00:05:57,280 --> 00:06:01,080 +investors، يعني التزامات محدودة، it means the + +73 +00:06:01,080 --> 00:06:05,600 +investors they are liable to the amount of money + +74 +00:06:05,600 --> 00:06:10,100 +that invest in the company، يعني هم فقط بيخسروا + +75 +00:06:10,100 --> 00:06:14,400 +الأموال اللي هم استثمروها في الشركة، يعني مثلا، يعني + +76 +00:06:14,400 --> 00:06:19,960 +مثلا إذا كان عندهم استثمار في استثمار، يعني إذا كان + +77 +00:06:19,960 --> 00:06:22,260 +أسهم عادية بتاعتهم قيمتها عشرة مليون دولار، + +78 +00:06:22,260 --> 00:06:26,660 +فالخسائر لا تتعدى العشرة مليون دولار، okay، هاي + +79 +00:06:26,660 --> 00:06:30,540 +بيسموها limited liability، limited liabilities، it + +80 +00:06:30,540 --> 00:06:36,290 +means their liable is not exceed the amount that + +81 +00:06:36,290 --> 00:06:39,350 +they invest in the company، يعني التزاماتهم لا + +82 +00:06:39,350 --> 00:06:43,550 +تتعدى الأموال اللي بيستثمروها، مثلا إذا كان زي ما + +83 +00:06:43,550 --> 00:06:48,250 +حكينا عشرة مليون دولار، مستثمرين أو اللي هم أسهم + +84 +00:06:48,250 --> 00:06:52,410 +عادية بهذا المبلغ، وبالتالي الخسائر تبعتهم لا تتعدى + +85 +00:06:52,410 --> 00:06:57,930 +العشرة مليون دولار اللي هم مستثمرينها، okay، نحكي عن + +86 +00:06:57,930 --> 00:06:58,650 +الـ preferred stock، + +87 +00:07:01,390 --> 00:07:08,730 +الـ preferred stock هي أسهم ممتازة، okay، هاي الأسهم + +88 +00:07:08,730 --> 00:07:13,290 +ممتازة بتختلف عن الأسهم العادية في اختلاف أول بالـ + +89 +00:07:13,290 --> 00:07:16,030 +par value، مثلا الـ par value اللي كم الـ stock عادة + +90 +00:07:16,030 --> 00:07:19,070 +one dollar، من ناحية المحاسبية، الـ preferred stock + +91 +00:07:19,070 --> 00:07:23,310 +ten dollar، هذا فرق مش كتير جوهري، نجعل الـ .. + +92 +00:07:23,310 --> 00:07:26,490 +الـ preferred stock، لاحظين احنا مكتوب perpetuity، + +93 +00:07:26,490 --> 00:07:33,160 +perpetuity يعني أبدية، يعني أتم، there is no + +94 +00:07:33,160 --> 00:07:36,940 +maturity date for the preferred stock، ما فيش + +95 +00:07:36,940 --> 00:07:41,920 +maturity date، ما فيش تاريخ استحقاق للـ .. للـ + +96 +00:07:41,920 --> 00:07:46,360 +preferred stock، يعني هيتم إصدارها بدون تواريخ + +97 +00:07:46,360 --> 00:07:51,960 +استحقاق، and this part of preferred stock is a + +98 +00:07:51,960 --> 00:07:58,140 +hybrid، what it means hybrid، يعني hybrid، يعني تجمع + +99 +00:07:58,140 --> 00:08:02,720 +أكثر من خاصيتين، the .. the characteristics of the + +100 +00:08:02,720 --> 00:08:05,900 +common stock and the characteristics of bond، يعني + +101 +00:08:05,900 --> 00:08:08,880 +بتشمل بين .. تجمع بين خاصيتين، خاصية الـ common + +102 +00:08:08,880 --> 00:08:14,080 +stock و خاصية الـ .. الـ bond، السندات، so it have + +103 +00:08:14,080 --> 00:08:17,700 +or it .. it has the advantages of both، بتجمع + +104 +00:08:17,700 --> 00:08:23,200 +خصائص ومميزات التنتين، sometimes they call this + +105 +00:08:23,200 --> 00:08:31,540 +hybrid، hybrid يعني مختلطة، لها ميزة مختلطة، سموها + +106 +00:08:31,540 --> 00:08:31,880 +hybrid، + +107 +00:08:37,600 --> 00:08:41,580 +Okay، فبتجمع بين خصائص الأسهم العادية وبين خصائص + +108 +00:08:41,580 --> 00:08:48,520 +السندات، طيب نشوف fixed dividends، one of the + +109 +00:08:48,520 --> 00:08:52,660 +characteristics of fixed dividends، عائذة بتقن this + +110 +00:08:52,660 --> 00:08:59,480 +is looks like bonds، بتشبه الـ bonds، تشبه السندات، + +111 +00:08:59,480 --> 00:09:06,540 +okay، لأنه الـ .. الـ .. الـ bond paid fixed income، + +112 +00:09:06,540 --> 00:09:11,280 +بتدفع fixed income، priority over the .. over common + +113 +00:09:11,280 --> 00:09:15,480 +stock، زي ما حكينا قبل شوية أنه لما بنعمل + +114 +00:09:15,480 --> 00:09:18,040 +priorities .. priorities، أولوية، when the .. when + +115 +00:09:18,040 --> 00:09:21,700 +the company go to bankruptcy، So according to + +116 +00:09:21,700 --> 00:09:26,580 +regulations، they rank the investors or the + +117 +00:09:26,580 --> 00:09:30,760 +securities according to the priority، برتبوهم حسب + +118 +00:09:30,760 --> 00:09:35,340 +الـ priority، لما احنا بندفع للـ investors، لما يصير + +119 +00:09:35,340 --> 00:09:39,320 +في عندنا إفلاس، وبالتالي هان، لما احنا بنرتبهم، لو + +120 +00:09:39,320 --> 00:09:43,560 +عملنا واحد، اتنين، تلاتة، أربعة، آخر إشي بيجي الـ + +121 +00:09:43,560 --> 00:09:47,960 +common stock، and before the common stock، before + +122 +00:09:47,960 --> 00:09:48,580 +the preferred stock، + +123 +00:09:51,550 --> 00:09:54,050 +إلى حق الأولوية، before they prepare the stock + +124 +00:09:54,050 --> 00:09:58,550 +عندنا الـ bond، إذا احنا بنرجع before the bonds الـ + +125 +00:09:58,550 --> 00:10:01,190 +taxation، ضريبة الحكومة، before the taxation، + +126 +00:10:01,190 --> 00:10:05,910 +salaries, employees' salaries and so on. Okay, so from + +127 +00:10:05,910 --> 00:10:09,450 +government to government or from country to + +128 +00:10:09,450 --> 00:10:12,710 +country, there are some little changes in the + +129 +00:10:12,710 --> 00:10:16,910 +priority over the securities. يعني حسب كل دولة + +130 +00:10:17,840 --> 00:10:21,940 +بيحددوا إيش الـ priorities الأولويات. لكن in general + +131 +00:10:21,940 --> 00:10:26,620 +بشكل عام بيكون الـ preferred stock is before the + +132 +00:10:26,620 --> 00:10:31,300 +common stock. ده ما يصير فيه عندنا سداد للاموال + +133 +00:10:31,300 --> 00:10:39,920 +المستثمرين، tax treatment، الـ tax treatment the + +134 +00:10:39,920 --> 00:10:42,580 +dividends which is looks like the common stock + +135 +00:10:42,580 --> 00:10:45,440 +treatment. تشبه الـ common stock treatment + +136 +00:10:50,520 --> 00:10:57,820 +المستخدمين في السوق المفضل يدفعون تاكس على الدفعات + +137 +00:10:57,820 --> 00:11:06,960 +وهو يسمى إذا قمت بفتح صفحة، صفحة + +138 +00:11:06,960 --> 00:11:14,740 +43 فالسوق العام ليس مستخدم للدفع تاكس ما يعنيه + +139 +00:11:14,740 --> 00:11:20,680 +تاكس لا تاكس مستخدم. In the bonds, the tax is + +140 +00:11:20,680 --> 00:11:25,760 +deducted from the expenses. However, in the + +141 +00:11:25,760 --> 00:11:29,380 +preferred stock, the tax is not deducted from the + +142 +00:11:29,380 --> 00:11:35,460 +expenses. يعني بحالة السندات، الفائدة + +143 +00:11:35,460 --> 00:11:40,260 +يتم طرحها من المصاريف وبالتالي بيصير عندنا إعفاء + +144 +00:11:40,260 --> 00:11:46,750 +ضريبي. لكن بالأسهم الممتازة، الـ dividends بتاعة الـ + +145 +00:11:46,750 --> 00:11:50,490 +preferred stock لا يتم اختصامها أو قطعها من + +146 +00:11:50,490 --> 00:11:53,690 +المصاريف وبالتالي لا تتمتع بوفرة ضريبية. And this is + +147 +00:11:53,690 --> 00:11:56,730 +a disadvantage of the preferred stock. وهذه واحدة من + +148 +00:11:56,730 --> 00:12:02,310 +العيوب بتاعة الـ preferred stock، الأسهم الممتازة. Okay. + +149 +00:12:04,930 --> 00:12:09,870 +بالنسبة للسندات، regarding the tax treatment, the + +150 +00:12:09,870 --> 00:12:13,230 +interest payment is deducted from tax... from + +151 +00:12:13,230 --> 00:12:19,210 +expenses. يعني الفائدة يتم اختطاعها من المصاريف. And + +152 +00:12:19,210 --> 00:12:22,410 +so we have tax exempted. وبالتالي بنحصل على إعفاء + +153 +00:12:22,410 --> 00:12:27,440 +ضريبي. لكن for the preferred stock, it is not tax + +154 +00:12:27,440 --> 00:12:31,720 +deducted from the expenses. هي لا يتم اختطاعها من + +155 +00:12:31,720 --> 00:12:36,740 +المصاريف. And so we cannot have the tax exempted + +156 +00:12:36,740 --> 00:12:41,740 +ومش هيتمتع في إعفاء ضريبي. فهذه الفروقات بين الـ + +157 +00:12:41,740 --> 00:12:48,120 +preferred stock and the common stocks. Okay. + +158 +00:12:52,340 --> 00:12:56,060 +American depository receipts. هاي ما الناس نحكي + +159 +00:12:56,060 --> 00:13:04,400 +فيها. آخر واحدة، stock market indexes. نحكي على أسواق + +160 +00:13:04,400 --> 00:13:10,120 +المؤشرات، أسواق الأسهم، stock market indexes. Some + +161 +00:13:10,120 --> 00:13:13,420 +people, they call stock market indices. بعض الناس + +162 +00:13:13,420 --> 00:13:17,420 +بالفظها indices. سواء كانت indices ولا indices are + +163 +00:13:17,420 --> 00:13:23,880 +the same. مؤشرات أسواق الأسهم. لو أنتو... اكتبوا + +164 +00:13:23,880 --> 00:13:29,520 +معناها... لو أنتو مثلا فاتحتوا مثلا الجزيرة + +165 +00:13:29,520 --> 00:13:36,720 +الاقتصادية أو العربية أو CNBC. هتيجي آخر اليوم حصاد + +166 +00:13:36,720 --> 00:13:42,130 +اقتصادي بيجي بيحكي مثلا الـ Dow Jones مثلا انخفض أو + +167 +00:13:42,130 --> 00:13:46,550 +ارتفع. بيجي بيحكي الـ 4100 ارتفع أو انخفض. بيجي بيحكي + +168 +00:13:46,550 --> 00:13:51,470 +S&P 500 ارتفع أو انخفض. بيحكي الـ CAC 40 انخفض أو + +169 +00:13:51,470 --> 00:13:54,690 +ارتفع. هدول مش شركات، هدول عبارة عن مؤشرات، أسباب + +170 +00:13:54,690 --> 00:13:57,370 +مالية. يعني مثلا لو أجيب نحكي على New York Stock + +171 +00:13:57,370 --> 00:14:03,290 +Exchange، New York Stock Exchange، New York Stock + +172 +00:14:03,290 --> 00:14:08,810 +Exchange. هذا سوق بدوم آلاف الشركات. فلمّا بنعمل + +173 +00:14:08,810 --> 00:14:13,770 +تقرير عن أداء السوق، مانفعش نعمل تقرير عن كل شركة + +174 +00:14:13,770 --> 00:14:19,610 +فالـ financial market committee اللي هو لجنة + +175 +00:14:19,610 --> 00:14:23,970 +الأسواق المالية قررت أنه تـ select particular + +176 +00:14:23,970 --> 00:14:29,230 +companies based on a particular criteria. To select + +177 +00:14:29,230 --> 00:14:31,910 +particular companies based on the particular + +178 +00:14:31,910 --> 00:14:35,570 +criteria to be in the index. يعني مثلا لو أنا عندي + +179 +00:14:35,570 --> 00:14:38,430 +3000 شركة مثلا موجودة بالـ New York Stock Exchange + +180 +00:14:39,590 --> 00:14:44,730 +They select for instance 500 companies from the + +181 +00:14:44,730 --> 00:14:48,630 +3000 based on a particular criteria to represent + +182 +00:14:48,630 --> 00:14:52,370 +the financial market. يعني بيختاروا أفضل مثلا 500 + +183 +00:14:52,370 --> 00:14:54,610 +شركة حسب market capitalization، market + +184 +00:14:54,610 --> 00:14:59,730 +capitalization. يعني حجم القيمة السوقية للشركة بحيث + +185 +00:14:59,730 --> 00:15:02,790 +أن هدول بيمثلوا السوق. فبدل ما هم يقيصوا السوق من + +186 +00:15:02,790 --> 00:15:06,890 +خلال 3000 أو 4000 شركة فبيقيصوا السوق من قبل أفضل + +187 +00:15:06,890 --> 00:15:12,410 +500 شركة في السوق أو أكبر 500 شركة أو أكبر 500 شركة + +188 +00:15:12,410 --> 00:15:16,670 +حسب القيمة السوقية. فهم بيختاروا من الـ 3000 هدول + +189 +00:15:16,670 --> 00:15:22,150 +بيختارونهم 500 شركة مثلا في الـ FTSE 100 اللي هو + +190 +00:15:22,150 --> 00:15:25,670 +جاي من London Stock Exchange، London Stock Exchange + +191 +00:15:25,670 --> 00:15:30,910 +LSE. هذا سوق لندن، السوق لندن في 6000 و 10000 شركة + +192 +00:15:30,910 --> 00:15:38,520 +يعتبر هذا السوق من بمثل تقريبا خمسة وعشرين في + +193 +00:15:38,520 --> 00:15:42,980 +المية من قيمة السوقية للعالم، تمام؟ سوق لندن، سوق + +194 +00:15:42,980 --> 00:15:49,060 +لندن هال... آلاف الشركات. هدول بدل ما احنا نروح + +195 +00:15:49,060 --> 00:15:53,600 +نمثل السوق كله بألاف الشركات، فبروح بختاروا أفضل + +196 +00:15:53,600 --> 00:15:58,990 +مئه شركة وبالتالي سموه الـ FTSE 100. فوتي one + +197 +00:15:58,990 --> 00:16:01,470 +hundred. فوتي one hundred اللي هو Financial Time + +198 +00:16:01,470 --> 00:16:05,070 +Stock Exchange for one hundred companies. فهم + +199 +00:16:05,070 --> 00:16:08,010 +بيروحوا بيشوفوا الخمس آلاف شركة، بيختاروا أفضل مئة + +200 +00:16:08,010 --> 00:16:10,910 +شركة حسب القيمة السوقية وبيروحوا بيحكوا بيصيروا + +201 +00:16:10,910 --> 00:16:14,590 +يحكوا فقط على الـ FTSE one hundred. إذا مثلا الـ FTSE + +202 +00:16:14,590 --> 00:16:18,890 +one hundred is includes the best one hundred + +203 +00:16:18,890 --> 00:16:22,130 +companies in the London Stock Exchange. يعني بيضم + +204 +00:16:22,130 --> 00:16:26,250 +أفضل مئة شركة في سوق لندن. إذا احنا بنحكي مثلا على + +205 +00:16:26,250 --> 00:16:30,930 +الـ... أمثلة كتير، في عندنا الـ CAC 40 وفي عندنا + +206 +00:16:30,930 --> 00:16:36,850 +Tokyo، سوق Tokyo، we have S&P 500، هذا سوق + +207 +00:16:36,850 --> 00:16:41,330 +الولايات المتحدة الأمريكية، في عندنا اسطنبول، + +208 +00:16:41,330 --> 00:16:44,290 +اسطنبول، في عندنا اسطنبول كمان، عندهم تقريبا + +209 +00:16:44,290 --> 00:16:51,470 +مؤشرهم على معتقد بضم 40 حوالي أربعين شركة حسب كل الـ + +210 +00:16:51,470 --> 00:16:53,930 +regulations. عندنا في سوق فلسطين أوراق المالية + +211 +00:16:53,930 --> 00:16:57,810 +لفترة متأخرة كان بيضم هذا السوق عشر شركات. الآن + +212 +00:16:57,810 --> 00:17:01,510 +طبعا بيضم أكتر من عشر شركات كمؤشر، as a index + +213 +00:17:06,510 --> 00:17:09,430 +الشركات الكبيرة نسميها في... طبعا احنا بنحكي هنا + +214 +00:17:09,430 --> 00:17:13,490 +عن Dow Jones. الشركات الكبيرة بيسموها blue chip، الـ + +215 +00:17:13,490 --> 00:17:17,050 +blue chip company، blue chip اللي هو القطعة الزرقاء + +216 +00:17:17,050 --> 00:17:22,370 +أيه. اجا القطعة الزرقاء الـ blue chip اجت من طبعا + +217 +00:17:22,370 --> 00:17:25,570 +اجت من الأسف الشديد، اجت من ألعاب الـ gambling + +218 +00:17:28,210 --> 00:17:31,470 +المقامرة. فالقطع الزرقاء هذه تعتبر أغلى قطعة + +219 +00:17:31,470 --> 00:17:34,370 +واحتمالات النجاح فيها احتمالات عالية جدا. فهذه + +220 +00:17:34,370 --> 00:17:38,550 +بيسموها blue chip. فـ الـ companies with a blue chip + +221 +00:17:38,550 --> 00:17:42,410 +يعني تكون هي blue chip، it is should be considered + +222 +00:17:42,410 --> 00:17:45,910 +as one of the index member. يعني تعتبر واحدة من + +223 +00:17:45,910 --> 00:17:53,230 +الشركات الممكن أن تكون في الشركات المساهمة في مؤشر + +224 +00:17:53,230 --> 00:17:59,160 +السوق. The question is how we can calculate the + +225 +00:17:59,160 --> 00:18:08,120 +index. كيف احنا ممكن... blue chip هي لما نيجي نقول + +226 +00:18:08,120 --> 00:18:14,060 +هاي البنات هدول في عندنا بنات متفوقات وفي بنات + +227 +00:18:14,060 --> 00:18:18,720 +يعني متوسطات وفي بنات عادية. إذا احنا بنختار the + +228 +00:18:18,720 --> 00:18:22,700 +best ten students، هدول بيسموهم، بيسميهم the blue + +229 +00:18:22,700 --> 00:18:27,810 +chip student. إيش يعني blue chip student؟ يعني أفضل + +230 +00:18:27,810 --> 00:18:31,430 +الطلاب دول بيسموه blue chip. فهذا مصطلح في الـ + +231 +00:18:31,430 --> 00:18:34,810 +financial markets. الـ blue chip it means the best + +232 +00:18:34,810 --> 00:18:42,250 +Okay. فليش سموها blue chip؟ لأنه في صلاة القمار في + +233 +00:18:42,250 --> 00:18:45,010 +عندنا قطعة... قطعة لونها أصفر، قطعة لونها أحمر، + +234 +00:18:45,010 --> 00:18:48,810 +قطعة لونها أسود، قطعة لونها أزرق، فأغلى قطعة هي + +235 +00:18:48,810 --> 00:18:53,250 +القطعة الزرقاء. والقطعة الزرقاء نفسها الـ blue chip + +236 +00:18:53,250 --> 00:18:57,730 +بتكون the most expensive and the most probable to + +237 +00:18:57,730 --> 00:19:03,430 +win. واحتماليات الربح تبقى هتكون أعلى comparing + +238 +00:19:03,430 --> 00:19:07,610 +or relative to the other chips. مقارنة مع القطع + +239 +00:19:07,610 --> 00:19:11,090 +الأخرى. + +240 +00:19:11,090 --> 00:19:17,220 +يعني لو أجينا احنا هقولنا the best students are more + +241 +00:19:17,220 --> 00:19:20,660 +probable to finish their graduate on this year. + +242 +00:19:20,660 --> 00:19:27,160 +يعني أكتر احتمال أن هم يخلصوا السنة هذه أو to pass + +243 +00:19:27,160 --> 00:19:32,100 +the exam easily أو يخلصوا الامتحان تبعهم بسهولة. + +244 +00:19:32,100 --> 00:19:38,220 +فهذا المصطلح أتي من هنا اسمه blue chip. Okay. The + +245 +00:19:38,220 --> 00:19:42,040 +question is how we can calculate or estimate the + +246 +00:19:45,570 --> 00:19:49,990 +the index. كيف احنا ممكن نختار الـ index? There is + +247 +00:19:49,990 --> 00:19:53,130 +two different ways or two different methods to + +248 +00:19:53,130 --> 00:19:56,410 +calculate the index. فينا طريقتين. The first one is + +249 +00:19:56,410 --> 00:19:59,930 +the price weighted in average and the second is + +250 +00:19:59,930 --> 00:20:05,110 +the average the market value weighted index. So the + +251 +00:20:05,110 --> 00:20:07,890 +first one is the price, the second one is the + +252 +00:20:07,890 --> 00:20:14,090 +markets, the market value. So we have two different + +253 +00:20:14,090 --> 00:20:20,710 +types of... of estimating the... the index يعني زي + +254 +00:20:20,710 --> 00:20:25,730 +ما أنتم بتسمعوا مثلا بالجزيرة أو بال CNBC أو in + +255 +00:20:25,730 --> 00:20:30,030 +CNN the index... the market index for instance for + +256 +00:20:30,030 --> 00:20:36,670 +the FTSE 100 is increased by five points. If we look + +257 +00:20:36,670 --> 00:20:40,450 +at the... if you look at the Google, if you open + +258 +00:20:40,450 --> 00:20:44,110 +Google, just write the FTSE 100 or write Dow Jones + +259 +00:20:44,110 --> 00:20:49,990 +or S&P 500. So these indexes or indices represent a + +260 +00:20:49,990 --> 00:20:53,630 +particular financial markets, it may increase by + +261 +00:20:53,630 --> 00:20:57,110 +points or decrease by points. هي بتنخفض و بترتفع + +262 +00:20:57,110 --> 00:21:06,550 +حسب النقاط. Dow Jones, this is... Dow Jones is the + +263 +00:21:06,550 --> 00:21:12,530 +first person back to 19s, the early of 19s, around + +264 +00:21:12,530 --> 00:21:18,650 +1905, سنة ألف وتسعمائة وخمسة, he suggested a theory which + +265 +00:21:18,650 --> 00:21:23,010 +is called Dow theory. اختراع نظرية سماها Dow theory + +266 +00:21:23,010 --> 00:21:29,690 +نظرية Dow, and this Dow theory depends on the + +267 +00:21:29,690 --> 00:21:35,390 +assumption that the financial market is moved by + +268 +00:21:35,390 --> 00:21:40,350 +the behavioral finance. يعني بتحركها ال behavioral + +269 +00:21:40,350 --> 00:21:43,970 +finance اللي هو السلوك المالي أو the behavior of + +270 +00:21:43,970 --> 00:21:50,050 +investors أو سلوك المستثمرين. And this Dow, هذا + +271 +00:21:50,050 --> 00:21:56,900 +الشخص اسمه Dow, was the first one to estimate the + +272 +00:21:56,900 --> 00:22:01,100 +market index. هو كان أول واحد بيعمل estimation يعني + +273 +00:22:01,100 --> 00:22:05,060 +calculate the market index. هو مؤشر السوق. And after + +274 +00:22:05,060 --> 00:22:07,560 +that, there are some other people, they try to + +275 +00:22:07,560 --> 00:22:12,280 +update and to amend the calculations of... of the + +276 +00:22:12,280 --> 00:22:17,640 +index. حاولوا ي... يغيروا في ال calculations لل... + +277 +00:22:17,640 --> 00:22:23,080 +لل index. لأ just they... they have little change + +278 +00:22:23,080 --> 00:22:27,640 +but the first one to coin the... the concept of + +279 +00:22:27,640 --> 00:22:34,720 +index was Dow. أول واحد أوجد فكرة ال index أو حسب + +280 +00:22:34,720 --> 00:22:39,640 +ال... ال index هو... هو Dow Jones في... في نظرية + +281 +00:22:39,640 --> 00:22:45,560 +Dow. سماها Dow theory. Okay, this is why, okay. + +282 +00:22:48,590 --> 00:22:51,010 +Let's see for instance how we calculate the... + +283 +00:22:51,010 --> 00:22:57,930 +based on the price weighted in + +284 +00:22:57,930 --> 00:23:02,310 +price weighted... ال price weighted يعني حسب السعر + +285 +00:23:02,310 --> 00:23:09,970 +المؤجح. If we have two stock, إذا كان عندي two + +286 +00:23:09,970 --> 00:23:11,630 +stocks. سهمين + +287 +00:23:15,320 --> 00:23:21,140 +stock A and stock B. يعني إذا كان ال index, if the + +288 +00:23:21,140 --> 00:23:24,900 +index includes only two stocks. يعني إذا بس بيشمل + +289 +00:23:24,900 --> 00:23:29,540 +سهمين A and B, we should know the price of A and + +290 +00:23:29,540 --> 00:23:34,440 +the price of B. لازم نعرف سعر A وسعر B according to + +291 +00:23:34,440 --> 00:23:38,820 +your example for instance, the price of A is 25$. + +292 +00:23:38,820 --> 00:23:45,300 +And the price of B is 100$. This is from for + +293 +00:23:45,300 --> 00:23:47,500 +instance for today or for from the previous day. + +294 +00:23:47,500 --> 00:23:52,340 +Now we observe the changes in the price. باللاحظ + +295 +00:23:52,340 --> 00:23:55,420 +التغير في الأسعار. For instance, if this is for + +296 +00:23:55,420 --> 00:24:00,700 +today, today is zero. And if we observe for tomorrow + +297 +00:24:01,710 --> 00:24:06,570 +and tomorrow is coming. وبكرة إجا. And the price is + +298 +00:24:06,570 --> 00:24:13,030 +like this, 30 for A and 90 for B. It means stock A + +299 +00:24:13,030 --> 00:24:19,110 +increased by 5 and stock B decreased by 10. If we + +300 +00:24:19,110 --> 00:24:23,610 +calculate the sum of this, 125. If we calculate the + +301 +00:24:23,610 --> 00:24:29,830 +sum of this, is 130. What you observe tomorrow, when + +302 +00:24:29,830 --> 00:24:34,390 +tomorrow is coming, the price is increased by five + +303 +00:24:34,390 --> 00:24:42,550 +dollars, 120. Okay, sorry for this. So the the price is + +304 +00:24:42,550 --> 00:24:48,210 +decreased by five dollars. السعر انخفض بكم five + +305 +00:24:48,210 --> 00:24:51,170 +dollars as a percentage. إذا احنا بنحسبه على + +306 +00:24:51,170 --> 00:24:56,630 +percentage, so five divided by the original price, + +307 +00:24:56,630 --> 00:25:01,290 +السعر الرئيسي اللي هو مية وخمسة وعشرين, فبيطلع + +308 +00:25:01,290 --> 00:25:05,650 +minus four percent. You + +309 +00:25:05,650 --> 00:25:09,370 +just only observe the changes in the prices, okay. + +310 +00:25:09,370 --> 00:25:16,910 +So the difference from tomorrow regarding today is + +311 +00:25:16,910 --> 00:25:20,490 +the price decreased by minus five. Minus five is + +312 +00:25:20,490 --> 00:25:23,830 +divided by the original price, which which was one + +313 +00:25:23,830 --> 00:25:28,350 +to five. So minus five divided by one to five, minus + +314 +00:25:28,350 --> 00:25:31,750 +four percent. It means when you listen to الجزيرة + +315 +00:25:31,750 --> 00:25:35,930 +or you listen for CNBC, they are saying that the + +316 +00:25:35,930 --> 00:25:40,890 +market index is decreased by four percent. يعني + +317 +00:25:40,890 --> 00:25:48,370 +المؤشر انخفض four percent. لكن هذا ليس بسيط كما + +318 +00:25:48,370 --> 00:25:53,930 +تعتقدون لأن هناك تطورات في الطريق أو في الأسلوب + +319 +00:25:53,930 --> 00:25:57,630 +كيف يقوموا بتخصيص اتجارات السوق. ولكن في هذا + +320 +00:25:57,630 --> 00:26:01,610 +المستقبل أو في هذه القصة فقط لدينا تقريب كيف + +321 +00:26:01,610 --> 00:26:06,460 +يقوموا بتخصيص اتجارات السوق. ما تفكروش أنه هذا هو ال + +322 +00:26:06,460 --> 00:26:10,100 +... هيك الطريقة النهائية. يعني هذي the first time + +323 +00:26:10,100 --> 00:26:13,240 +they calculate. أول مرة حسبوها بهذه الطريقة هذي. + +324 +00:26:13,240 --> 00:26:18,940 +Then they develop these calculations. طوروا فيها... + +325 +00:26:18,940 --> 00:26:21,560 +بقى. This is the... the main idea of how calculate + +326 +00:26:21,560 --> 00:26:24,420 +the market indices. ما هو اسمه ال price weight is + +327 +00:26:24,420 --> 00:26:28,160 +different لأنه يساعد كل دمال الشركة بتطلع ال price + +328 +00:26:28,160 --> 00:26:32,520 +weight is because the index is built on the price + +329 +00:26:33,400 --> 00:26:39,600 +لأن طريقة الحسبة على السعر and not considering the + +330 +00:26:39,600 --> 00:26:43,260 +number of shares. وماعتمدتش على number of shares + +331 +00:26:43,260 --> 00:26:48,280 +على عدد الأسهم. Just only focus on the price. بس ركز + +332 +00:26:48,280 --> 00:26:53,480 +على ال price. This + +333 +00:26:53,480 --> 00:26:57,980 +is the portfolio if it includes two stocks and if + +334 +00:26:57,980 --> 00:27:01,160 +the market includes two stocks and if we calculate + +335 +00:27:01,160 --> 00:27:05,710 +the index in the same or in the similar way. إذا + +336 +00:27:05,710 --> 00:27:11,210 +احنا حابين نحسب ال index بال similar way. مؤشر, look + +337 +00:27:11,210 --> 00:27:18,610 +at here, we here we we use two stocks. So we ignore + +338 +00:27:18,610 --> 00:27:22,710 +the average. احنا جهلنا ال average. So we amend the + +339 +00:27:22,710 --> 00:27:25,470 +average by using the index. بس انه احنا بنعمل + +340 +00:27:25,470 --> 00:27:30,070 +amending. بنعمل amending يعني يعني كأنه احنا قلنا + +341 +00:27:30,070 --> 00:27:34,550 +قداش أنا بعت الطلاب الفصل هذا العلامات الطلاب جمعنا + +342 +00:27:34,550 --> 00:27:40,460 +كل العلامات. قلنا العلامات الفينطيب و الفاصل الماضي + +343 +00:27:40,460 --> 00:27:43,680 +كام؟ ألف وتسعمائة. إذا فيه زيادة مية، هاي الطريقة + +344 +00:27:43,680 --> 00:27:46,320 +الطريقة التانية لأ إحنا بنحسب... بنقول قداش ال + +345 +00:27:46,320 --> 00:27:50,620 +average تبع الطلاب الفاصل الفاتر و كام ال average + +346 +00:27:50,620 --> 00:27:54,080 +تبع الطلاب الفاصل التاني وبالتالي لازم إحنا ن... ن + +347 +00:27:54,080 --> 00:27:58,260 +... نحسب خمسة وعشرين twenty five plus one hundred + +348 +00:27:58,260 --> 00:28:01,540 +divided by two. Why two? Because we only have two + +349 +00:28:01,540 --> 00:28:04,880 +companies. نستطيع أن نقلها إلى 3 إذا كان لدينا ثلاث + +350 +00:28:04,880 --> 00:28:10,740 +شركات، لذلك نستطيع أن نقلها إلى N باستخدام N كمية + +351 +00:28:10,740 --> 00:28:14,660 +الشركات. نقلها + +352 +00:28:14,660 --> 00:28:22,540 +إلى 25 مرة ونقلها + +353 +00:28:22,540 --> 00:28:29,220 +إلى 2 مرة ونقلها إلى 2 مرة. So one two five divided + +354 +00:28:29,220 --> 00:28:34,180 +by two, it is sixty two point five. And this is + +355 +00:28:34,180 --> 00:28:39,720 +sixty. Why we divided by two? Because we only have + +356 +00:28:39,720 --> 00:28:43,000 +two companies. If we have three, we divided by three. + +357 +00:28:43,000 --> 00:28:48,140 +If we have thirty, we divided by thirty. عدد الشركات + +358 +00:28:48,140 --> 00:28:51,060 +مش الأسهم, not the number of shares, be careful. + +359 +00:28:55,200 --> 00:28:59,940 +Yes, two companies or two stocks to simplify it. + +360 +00:28:59,940 --> 00:29:03,720 +يعني يا أما شركتين يا أما سهمين بس. Okay, so we + +361 +00:29:03,720 --> 00:29:06,580 +ignoring the number of shares so far. نتجاهل عدد + +362 +00:29:06,580 --> 00:29:10,320 +الأسهم لحد اللحظة هذه. Okay, very simple + +363 +00:29:10,320 --> 00:29:17,800 +calculations. طيب هلأ ستين minus sixty two point + +364 +00:29:17,800 --> 00:29:28,930 +five, which is -2.5. مقارنة بالتغيير الأصلي 62.5 + +365 +00:29:28,930 --> 00:29:34,970 +مقارنة بالتغيير + +366 +00:29:34,970 --> 00:29:39,010 +الأصلي + +367 +00:29:39,010 --> 00:29:41,750 +62.5. مقارنة بالتغيير الأصلي 62.5. مقارنة + +368 +00:29:41,750 --> 00:29:41,910 +الأصلي 62.5. مقارنة بالتغيير الأصلي 62.5. مقارنة + +369 +00:29:41,910 --> 00:29:42,110 +62.5. مقارنة بالتغيير الأصلي 62.5. مقارنة + +370 +00:29:42,110 --> 00:29:43,410 +الأصلي 62.5. مقارنة بالتغيير الأصلي 62.5. مقارنة + +371 +00:29:43,410 --> 00:29:50,370 +بالتغيير الأصلي 62.5. مقارنة + +372 +00:29:50,370 --> 00:29:51,870 +بالتغيير الأصل + +373 +00:29:55,300 --> 00:29:58,840 +هو يجب أن يكون السعر ليس السعر بل السعر الوضعي. + +374 +00:29:58,840 --> 00:30:04,020 +هذا + +375 +00:30:04,020 --> 00:30:10,180 +هو السعر الوضعي. هذه الطريقة هي السعر الوضعي لذا + +376 +00:30:10,180 --> 00:30:15,840 +يمكنك تخطيط هذا على الميزانية تخطيطات بسيطة أو + +377 +00:30:15,840 --> 00:30:22,700 +تخطيطات بسيطة أو تخطيطات بسيطة إذا أعطيك مثلا 30 + +378 +00:30:22,700 --> 00:30:26,900 +شركات وانت فقط تقيمها بالـ 30 و ترى التغيير في + +379 +00:30:26,900 --> 00:30:34,500 +السعر على هذا الهدف على سبيل المثال S&P500 كما + +380 +00:30:34,500 --> 00:30:41,040 +أشرحت في الأول 5-10 دقيقة تحتوي على أكبر من 500 + +381 +00:30:41,040 --> 00:30:45,760 +شركات في New York Stock Exchange. Okay, the largest + +382 +00:30:45,760 --> 00:30:49,080 +the largest based on the market capitalization + +383 +00:30:49,080 --> 00:30:51,980 +what it means market capitalization القيمة السوقية + +384 +00:30:51,980 --> 00:30:56,340 +يعني حسب القيمة السوقية and the market + +385 +00:30:56,340 --> 00:30:58,880 +capitalization is available for the every + +386 +00:30:58,880 --> 00:31:01,760 +investors. كل investor ممكن يحصل على market + +387 +00:31:01,760 --> 00:31:07,290 +capitalization and to calculate the index. لكن الـ S + +388 +00:31:07,290 --> 00:31:14,090 +&P ليس قيمة مثل داو جونز، داو جونز قيمة حسب القيمة + +389 +00:31:14,090 --> 00:31:19,890 +السوقية. ولكن الـ S&P كما قلت قبل أننا لدينا أشياء مختلفة من + +390 +00:31:19,890 --> 00:31:24,610 +القيمة، الأول هو قيمة القيمة والثاني هو قيمة السوق + +391 +00:31:26,390 --> 00:31:29,710 +So the market value weighted. طريقة احتساب الـ value + +392 +00:31:29,710 --> 00:31:32,430 +weighted is little different than the price + +393 +00:31:32,430 --> 00:31:35,830 +weighted. يعني بتختلف في شيء بسيط. it just consider + +394 +00:31:35,830 --> 00:31:38,910 +the number of shares. يعني بس بتاخد بعين الاعتبار + +395 +00:31:38,910 --> 00:31:44,050 +عدد الأسهم. okay + +396 +00:31:44,050 --> 00:31:47,370 +the + +397 +00:31:47,370 --> 00:31:55,950 +market weighted. go back to the. go back + +398 +00:31:58,520 --> 00:32:04,320 +نعود لبيج 45 + +399 +00:32:04,320 --> 00:32:09,060 +نعود + +400 +00:32:09,060 --> 00:32:16,280 +لبيج 45. تعود تعود عندما تذهب إلى المنزل تعود لبيج + +401 +00:32:16,280 --> 00:32:22,240 +45. في سبيل المثال 2.2. ميزة ميزة ميزة ميزة ميزة + +402 +00:32:22,240 --> 00:32:22,300 +ميزة ميزة ميزة ميزة ميزة ميزة ميزة + +403 +00:32:27,310 --> 00:32:31,710 +على سبيل المثال 2.2 هو السعر الوزراء الذي أشرحته + +404 +00:32:31,710 --> 00:32:39,630 +لك. بنفسك تحاول تقرأ سبيل 2.3 وهو قيمة وزراء فقط + +405 +00:32:39,630 --> 00:32:44,590 +تضيف رقم الشركات وقرأها. إذا لم تفهم في المجلس + +406 +00:32:44,590 --> 00:32:52,810 +القادم سأشرح لك معلومات أكثر عن هذا قد + +407 +00:32:52,810 --> 00:32:59,000 +يكون لديك مشكلة في فهم قيمة السوق. and this problem + +408 +00:32:59,000 --> 00:33:03,260 +may raise up because of the stock split. you know + +409 +00:33:03,260 --> 00:33:07,240 +what it means stock split. stock split. stock split + +410 +00:33:07,240 --> 00:33:11,280 +اللي هو التوزيع أو بيسموها تجزئة السهم. سمعتوا في + +411 +00:33:11,280 --> 00:33:15,760 +تجزئة السهم بالمحاسبة. in accounting stock splits + +412 +00:33:15,760 --> 00:33:20,820 +بالـ accounting أو بالـ management stock splits. ان + +413 +00:33:20,820 --> 00:33:23,700 +احنا ممكن يكون الـ investors have one hundred + +414 +00:33:23,700 --> 00:33:28,690 +shares. and when the company do stock splits it + +415 +00:33:28,690 --> 00:33:35,850 +becomes like two hundreds. stock splits اللي + +416 +00:33:35,850 --> 00:33:41,390 +هو تجزئة السهم. الشركات بتلجأ لتجزئة السهم في بعض + +417 +00:33:41,390 --> 00:33:44,990 +الحالات. ممكن يكون في زيادة في رأس المال عندهم. so + +418 +00:33:44,990 --> 00:33:49,170 +they do stock splits. بيعمل تجزئة للسهم. so one + +419 +00:33:49,170 --> 00:33:55,670 +stock may equal two stocks. ممكن يساوي سهمين. when + +420 +00:33:55,670 --> 00:33:58,810 +the company do stock splits. لما الشركة تعمل stock + +421 +00:33:58,810 --> 00:34:02,850 +splits. if you hold one hundred shares it becomes + +422 +00:34:02,850 --> 00:34:07,750 +two hundreds. try to read around the stock splits + +423 +00:34:07,750 --> 00:34:11,470 +حاولوا تقرؤوا حوالين الـ stock splits. okay and next + +424 +00:34:11,470 --> 00:34:14,690 +meeting I will try to give you details. حاولوا + +425 +00:34:14,690 --> 00:34:20,670 +تقرؤوا إيش معنى اسم الـ stock splits بالضبط. اه لكن + +426 +00:34:20,670 --> 00:34:26,130 +بيصير الـ market price متخفض. اقرؤوا + +427 +00:34:26,130 --> 00:34:28,290 +عشان المرة الجاية اعمل لكم more explanation about + +428 +00:34:28,290 --> 00:34:36,470 +this. طيب I give you example about other indexes + +429 +00:34:36,470 --> 00:34:39,910 +like New York Stock Exchange. like NASDAQ. هذا مؤشر + +430 +00:34:39,910 --> 00:34:44,710 +الأسهم الصناعية. Wilshire 5000's. عندنا Nikkei تبع + +431 +00:34:44,710 --> 00:34:49,330 +اليابان. و عندنا الفوتسيفوتسي one hundred. سوق الـ .. + +432 +00:34:49,330 --> 00:34:52,990 +لندن. السوق الـ exchange. وعنا dags طبعا ألمانيا. وفي + +433 +00:34:52,990 --> 00:34:57,610 +عندنا hang sing هونج كونج. هدول تعرفوا أن في مؤشرات + +434 +00:34:57,610 --> 00:35:00,690 +مش بس في الولايات المتحدة الأمريكية. في مؤشرات حتى + +435 +00:35:00,690 --> 00:35:04,390 +عندنا في سوق فلسطين. ايه فيه مؤشر. إيش بيسميه؟ مؤشر + +436 +00:35:04,390 --> 00:35:09,630 +مؤشر القدس. okay. مؤشر السوق الفلسطيني اسمه مؤشر + +437 +00:35:09,630 --> 00:35:15,630 +القدس. فكل سوق لازم يكون له مؤشر. نجف + +438 +00:35:15,630 --> 00:35:16,270 +عند هذا الحد diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/Qunp8-IbDZg.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/Qunp8-IbDZg.srt new file mode 100644 index 0000000000000000000000000000000000000000..f7cb2b2152f7552873115f803dea018e95f7f47f --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/Qunp8-IbDZg.srt @@ -0,0 +1,1639 @@ +1 +00:00:20,650 --> 00:00:25,090 +الله الرحمن الرحيم في + +2 +00:00:25,090 --> 00:00:28,990 +اللقاء الماضي كنا نحكي على ال versions of the + +3 +00:00:28,990 --> 00:00:31,550 +efficient market hypothesis اللي عندنا ال weak + +4 +00:00:31,550 --> 00:00:34,250 +market وعندنا ال semi-strong market وstrong + +5 +00:00:34,250 --> 00:00:38,550 +market the main differences between the versions + +6 +00:00:38,550 --> 00:00:41,550 +of the efficient market hypothesis to what extent + +7 +00:00:41,550 --> 00:00:45,230 +the information is incorporated in the prices يعني + +8 +00:00:45,230 --> 00:00:50,250 +الفرق ال ... ال ... ال ... الوحيداللي بيفرق بين أنواع + +9 +00:00:50,250 --> 00:00:55,070 +الكفاءات السوق هي لأي حد بتنعكس المعلومات في + +10 +00:00:55,070 --> 00:00:59,710 +الأسعار فإذا كانت المعلومات في حالة ال weak market + +11 +00:00:59,710 --> 00:01:02,950 +السوق الضعيف بتعكس فقط ال historical prices + +12 +00:01:02,950 --> 00:01:06,920 +الأسعار التاريخية بيكون هذا weak إذا كان ال semi + +13 +00:01:06,920 --> 00:01:11,060 +-strong market بيعكس الأسعار التاريخية بالإضافة + +14 +00:01:11,060 --> 00:01:14,320 +للأسعار الأساسية أو المعلومات الأساسية بيكون semi + +15 +00:01:14,320 --> 00:01:17,160 +-strong market ال strong market بيعكس كل أنواع + +16 +00:01:17,160 --> 00:01:21,100 +الأسعار كل أنواع المعلومات وفي اللقاء الفات يعني + +17 +00:01:21,100 --> 00:01:24,060 +بس أذكركم أن ال ... ال ... ال ... ال previous meeting + +18 +00:01:24,060 --> 00:01:29,420 +we say this is a weak market and this is the semi + +19 +00:01:29,420 --> 00:01:33,460 +-strong market and the last one is the strong + +20 +00:01:33,460 --> 00:01:41,520 +market السوق الضعيف يشبه أسعار التاريخ أو المعلومات + +21 +00:01:41,520 --> 00:01:46,780 +التاريخية، والسوق الضعيف يشبه أسعار التاريخ، + +22 +00:01:46,780 --> 00:01:51,020 +المعلومات التاريخية ومعلومات الأساسية، والسوق + +23 +00:01:51,020 --> 00:01:56,660 +الضعيف يشبه أسعار التاريخ، المعلومات التاريخية + +24 +00:01:56,660 --> 00:02:01,560 +ومعلومات الأساسية Okay So this is the thing + +25 +00:02:01,560 --> 00:02:04,800 +Regarding your exam one of the questions in your + +26 +00:02:04,800 --> 00:02:09,520 +exam is like correct the following statement يعني + +27 +00:02:09,520 --> 00:02:15,080 +في حسب الامتحان صحح المعلومات التالية خلينا + +28 +00:02:15,080 --> 00:02:19,540 +نعطيكوا مثال The weak market reflects + +29 +00:02:31,130 --> 00:02:36,470 +المعلومات القانونية فقط تقوم بإصلاح هذا الموضوع + +30 +00:02:36,470 --> 00:02:39,650 +لديك + +31 +00:02:39,650 --> 00:02:43,950 +2 اختيارات يمكنك أن ترى أن هذا مصمم مصمم مصمم مصمم + +32 +00:02:43,950 --> 00:02:44,470 +مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم + +33 +00:02:44,470 --> 00:02:45,390 +مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم + +34 +00:02:45,390 --> 00:02:49,290 +مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم مصمم + +35 +00:02:49,290 --> 00:02:57,930 +مصممم مصم + +36 +00:02:58,600 --> 00:03:07,760 +نشوف السؤال الآخر كيف هتنعامل معاه The + +37 +00:03:07,760 --> 00:03:16,380 +strong market incorporates + +38 +00:03:16,380 --> 00:03:21,360 +the + +39 +00:03:21,360 --> 00:03:27,200 +historical information + +40 +00:03:30,960 --> 00:03:38,580 +and fundamental information and + +41 +00:03:38,580 --> 00:03:45,100 +fundamental information what + +42 +00:03:45,100 --> 00:03:48,160 +do you think فقط فقط ولا مش فقط okay only for + +43 +00:03:48,160 --> 00:03:55,220 +instance corrective corrective where is the answer + +44 +00:03:55,220 --> 00:03:56,020 +the correct answer + +45 +00:03:59,130 --> 00:04:06,790 +بدل strong, semi-strong أو strong markets you just + +46 +00:04:06,790 --> 00:04:12,990 +add here and drive it okay I think this is very + +47 +00:04:12,990 --> 00:04:16,490 +simple questions هدول أسئلة سهلة and you can + +48 +00:04:16,490 --> 00:04:19,930 +easily handle these questions okay just be careful + +49 +00:04:19,930 --> 00:04:25,210 +on these questions انتبهوا لهذه الأسئلة you need + +50 +00:04:25,210 --> 00:04:33,090 +to correct the answer Okay then based on this + +51 +00:04:33,090 --> 00:04:37,390 +understanding we have two point of views some + +52 +00:04:37,390 --> 00:04:40,870 +people think that the financial market is not + +53 +00:04:40,870 --> 00:04:47,170 +efficient and is not follow the random walk others + +54 +00:04:47,170 --> 00:04:50,950 +think that the financial market is efficient and + +55 +00:04:50,950 --> 00:04:54,070 +follow a random walk يعني بعض الناس بعتقدوا أن + +56 +00:04:54,070 --> 00:04:58,800 +السوق المالي مش efficient وما بيعكس السوق المالي ما + +57 +00:04:58,800 --> 00:05:04,160 +بيعكس السلوك العشوائي للأسعار وبعض الناس بيحكوا + +58 +00:05:04,160 --> 00:05:07,760 +بيحكوا لأ ان السوق المالي is efficient كفه وبيعكس + +59 +00:05:07,760 --> 00:05:13,420 +السلوك ... وبيعكس السلوك العشوائي للأسعار طبعا بال + +60 +00:05:13,420 --> 00:05:16,180 +meeting اللي فاتت حكينا بال technical analysis + +61 +00:05:16,180 --> 00:05:20,380 +الناس اللي بيدعموا فكرة ال financial market is not + +62 +00:05:20,380 --> 00:05:26,220 +efficient they think on the technical analysis + +63 +00:05:26,220 --> 00:05:28,660 +بعتقدوا بال technical analysis so they are using + +64 +00:05:28,660 --> 00:05:31,060 +technical analysis why they are using technical + +65 +00:05:31,060 --> 00:05:35,380 +analysis because they think that the historical + +66 +00:05:35,380 --> 00:05:38,320 +prices is reflected itself بعتقدوا أن الأسعار + +67 +00:05:38,320 --> 00:05:42,520 +التاريخية بتعكس نفسها بنفسها so they are using the + +68 +00:05:42,520 --> 00:05:46,040 +charts لذلك وما بيستخدموا إيش ال chart إيش معناه + +69 +00:05:46,040 --> 00:05:51,800 +ال chart اللي هو المقاطعة البيانية فاهم بقى The + +70 +00:05:51,800 --> 00:05:54,360 +success depends on a sluggish response of stock + +71 +00:05:54,360 --> 00:05:57,400 +prices to fundamental supply and demand factors، + +72 +00:05:57,400 --> 00:06:03,440 +بعتقده أن ال technical analysis بترتب عليه ردود + +73 +00:06:03,440 --> 00:06:07,660 +فعل بطيئة + +74 +00:06:07,660 --> 00:06:12,410 +للمعلومات الأساسية weak firm efficiency relative + +75 +00:06:12,410 --> 00:06:15,870 +strength طبعا زي ما حكينا مرة فاتت بس تلخيص احنا + +76 +00:06:15,870 --> 00:06:20,570 +بنحكي انه في ال technical analysis بيحللوا ال + +77 +00:06:20,570 --> 00:06:24,650 +prices وبيحللوا ال trading volume و اظن ان انا + +78 +00:06:24,650 --> 00:06:29,560 +اعطيكم مثال على الشموع اليابانية فاكرين؟ واقتنعكوا + +79 +00:06:29,560 --> 00:06:32,200 +كمان على ال resistance and support اللي هو نقاط + +80 +00:06:32,200 --> 00:06:35,740 +الدعم ونقاط المقاومة وفيه هنا كتب موجودة بتوضح + +81 +00:06:35,740 --> 00:06:39,280 +العلاقات هذه بشكل كبير فممكن انتوا ترجعوا فيها بس + +82 +00:06:39,280 --> 00:06:45,500 +لمعلوماتكم الخاصة هاي عندنا مثال لما تكون + +83 +00:06:45,500 --> 00:06:49,640 +highlight channel when the price is close to the + +84 +00:06:49,640 --> 00:06:53,180 +to the top to the resistance the resistance + +85 +00:06:53,180 --> 00:06:57,510 +pushing the price down So the ... the investors + +86 +00:06:57,510 --> 00:07:00,510 +selling the price ... the stocks and when the + +87 +00:07:00,510 --> 00:07:04,470 +prices is going down and try to ... to touch or to + +88 +00:07:04,470 --> 00:07:07,510 +hit the support line, this is the support line, + +89 +00:07:08,230 --> 00:07:11,410 +the buyers try to trade and buy their stocks in + +90 +00:07:11,410 --> 00:07:14,210 +order to ... to make it up حتى يدفعوا الأسعار + +91 +00:07:14,210 --> 00:07:18,630 +للأسفل، بتلاحظوا لما يوصل عند القاع ال support + +92 +00:07:18,630 --> 00:07:22,470 +فبتحاول الأسعار تطلع لما تصدم في القمة بتحاول + +93 +00:07:22,470 --> 00:07:26,490 +الأسعار to what extent this is right إلى أي درجة + +94 +00:07:26,490 --> 00:07:29,550 +هذا صحيح some people as I said believe on this + +95 +00:07:29,550 --> 00:07:32,350 +others they don't believe on this بعض الناس + +96 +00:07:32,350 --> 00:07:36,670 +بيعتقدوا بالكلام هذا وناس بيعتقدوه مش بالكلام and + +97 +00:07:36,670 --> 00:07:42,370 +this is similar to this this is the top this is the + +98 +00:07:42,370 --> 00:07:45,710 +resistance and this is support the question is why + +99 +00:07:45,710 --> 00:07:53,450 +this channel is moved up ليش اخترقت نقطة الدعم + +100 +00:07:53,450 --> 00:08:00,670 +نقطة المقاومة اخترقها سبب انه بيعتبروا there is + +101 +00:08:00,670 --> 00:08:05,930 +event في حدث صار في السوق and this line وهذه نقطة + +102 +00:08:05,930 --> 00:08:09,980 +المقاومة ماقدرتش to push the price down ماقدرتش + +103 +00:08:09,980 --> 00:08:16,040 +تدفع الأسعار الأسفل فكان the strength and the fast + +104 +00:08:16,040 --> 00:08:19,580 +or the speed of price is stronger than the + +105 +00:08:19,580 --> 00:08:23,620 +resistance يعني كانت قوة الأسعار وسرعة الأسعار + +106 +00:08:23,620 --> 00:08:29,090 +أقوى من المقاومة وبالتالي اخترقت الحاجز المقاومة + +107 +00:08:29,090 --> 00:08:33,630 +وبدأت تطلع إلى مستويات أعلى and having a new + +108 +00:08:33,630 --> 00:08:39,450 +resistance and having a new position وتتجه لمجال + +109 +00:08:39,450 --> 00:08:44,330 +جديد هذا بالنسبة لل technical analysis let's talk + +110 +00:08:44,330 --> 00:08:47,290 +about the fundamental analysis fundamental + +111 +00:08:47,290 --> 00:08:50,870 +analysis people think that the financial market is + +112 +00:08:50,870 --> 00:08:54,010 +efficient they believe on the fundamental analysis + +113 +00:08:54,870 --> 00:08:59,950 +and they claim that the prices reflect economic ... + +114 +00:08:59,950 --> 00:09:03,630 +economic financial accounting and industrial data + +115 +00:09:03,630 --> 00:09:08,890 +بيعتقدوا بتوع ال fundamental analysis أن الأسواق + +116 +00:09:08,890 --> 00:09:12,330 +المالية أو الأسعار بتعكس معلومات حقيقية بتعكس + +117 +00:09:12,330 --> 00:09:15,190 +معلومات اقتصادية، معلومات مالية، معلومات محاسبية، + +118 +00:09:15,190 --> 00:09:19,460 +معلومات مستخبرية عن المنشأة and this is opposite to + +119 +00:09:19,460 --> 00:09:21,500 +the technical analysis وهذا بعكس ال technical + +120 +00:09:21,500 --> 00:09:24,000 +analysis ال technical analysis depends on the + +121 +00:09:24,000 --> 00:09:27,320 +chart and saying that the prices is repeated + +122 +00:09:27,320 --> 00:09:30,940 +itself technical analysis يعني التعوين التحديد + +123 +00:09:30,940 --> 00:09:33,620 +الفنلي بيعتقدوا أن الأسعار بتكرر نفسها لكن بال + +124 +00:09:33,620 --> 00:09:40,680 +fundamental analysis they think that the prices + +125 +00:09:40,680 --> 00:09:45,540 +reflected the fundamental value of the stock تعكس + +126 +00:09:45,540 --> 00:09:53,470 +القيمة الحقيقية للـ stock خلّينا نشوف why + +127 +00:09:53,470 --> 00:09:55,690 +it is important fundamental analysis as I + +128 +00:09:55,690 --> 00:09:57,910 +explained fundamental analysis using economic + +129 +00:09:57,910 --> 00:10:00,670 +accounting information to predict stock prices + +130 +00:10:00,670 --> 00:10:06,730 +يعني بيحاولوا يستخدموا الـ economic والـ accounting + +131 +00:10:06,730 --> 00:10:11,000 +information طبعا هي الـ economic مش الـ economics اللي + +132 +00:10:11,000 --> 00:10:14,440 +احنا بنفهمها بطريقة بسيطة الـ economics including + +133 +00:10:14,440 --> 00:10:18,180 +the economics, including the industrial, the + +134 +00:10:18,180 --> 00:10:20,700 +competition, the interest rates, unemployment + +135 +00:10:20,700 --> 00:10:23,900 +everything related to the economy كل شيء بتعلق + +136 +00:10:23,900 --> 00:10:29,580 +بالاقتصاد منها المنافسة منها التطور للصناعة منها + +137 +00:10:29,580 --> 00:10:33,560 +الـ export و الـ import everything related to the فعل + +138 +00:10:34,360 --> 00:10:37,960 +منها الـ risk and return of the firm and the + +139 +00:10:37,960 --> 00:10:39,740 +accounting information accounting information + +140 +00:10:39,740 --> 00:10:42,880 +which also includes the financial information بت + +141 +00:10:42,880 --> 00:10:45,200 +.. بتضم كمان معها الـ financial information + +142 +00:10:45,200 --> 00:10:49,780 +المعلومات المالية if you look at here fundamental + +143 +00:10:49,780 --> 00:10:52,100 +analysis هدول الناس اللي بيقتنعوا بالـ fundamental + +144 +00:10:52,100 --> 00:10:55,800 +analysis و and they call them fundamentals يعني + +145 +00:10:55,800 --> 00:10:59,300 +الناس الـ fundamentals are fundamentalist الناس + +146 +00:10:59,300 --> 00:11:02,440 +اللي بيقوموا بالـ .. بالتحليل الأساسي أو fundamental + +147 +00:11:02,440 --> 00:11:05,740 +analysis they try to calculate the fundamental + +148 +00:11:05,740 --> 00:11:11,120 +price بحاولوا أنه بناء على المعلومات الاقتصادية + +149 +00:11:11,120 --> 00:11:14,740 +والمعلومات المالية والمحاسبية ووضع السوق بحاولوا + +150 +00:11:14,740 --> 00:11:19,040 +يتنبأوا بالسعر الحقيقي الـ fundamental فلنفترض احنا + +151 +00:11:19,040 --> 00:11:23,050 +for instance the fundamental price is V0 لو احنا + +152 +00:11:23,050 --> 00:11:26,850 +حسبنا الـ fundamental price is V0، V is stand for + +153 +00:11:26,850 --> 00:11:30,170 +the value, the value of stock، بتوع الـ financial + +154 +00:11:30,170 --> 00:11:34,570 +management في الإدارة المالية، اذا درستوها، في + +155 +00:11:34,570 --> 00:11:38,270 +الإدارة المالية احنا حسبنا how to calculate the V0 + +156 +00:11:39,540 --> 00:11:42,240 +خاصة تعيين الـ financial management in English + +157 +00:11:42,240 --> 00:11:45,280 +والتعيين الـ financial management in Arabic يعني + +158 +00:11:45,280 --> 00:11:52,920 +أكيد أخدته كيف نحتسب القيمة الحقيقية لسعر السهم + +159 +00:11:53,680 --> 00:11:58,340 +Okay فهي الـ V note فإذا حسبنا الـ V note خلينا ناخد + +160 +00:11:58,340 --> 00:12:01,440 +مثلا نفترض الـ V note is fifty percent fifty dollar + +161 +00:12:01,440 --> 00:12:06,020 +سعر سهم حسبناه بناء على الـ based on the economic + +162 +00:12:06,020 --> 00:12:10,520 +accounting information data the V note is equal + +163 +00:12:10,520 --> 00:12:13,860 +fifty dollar V note هذي estimated + +164 +00:12:16,470 --> 00:12:20,890 +it means هذا المتوقع we think that the fair price + +165 +00:12:20,890 --> 00:12:23,630 +and the fundamental price of this stock is fifty + +166 +00:12:23,630 --> 00:12:28,790 +dollars يعني احنا بنعتقد سعر السهم اللازم يكون + +167 +00:12:28,790 --> 00:12:32,570 +خمسين دولار سعره الحقيقي بناء على ايش؟ بناء على + +168 +00:12:32,570 --> 00:12:35,470 +المعلومات الـ economic الاقتصاد ومعلومات الـ + +169 +00:12:35,470 --> 00:12:40,530 +accounting و الـ financial و everything now the B + +170 +00:12:40,530 --> 00:12:45,040 +note which is the market price هذا السعر الحقيقي + +171 +00:12:45,040 --> 00:12:51,640 +الموجود في السوق market price is for instance 40$ + +172 +00:12:51,640 --> 00:12:55,640 +روحنا + +173 +00:12:55,640 --> 00:12:59,660 +احنا حسبنا السعر كان 50$ حسبنا حسبنا لما روحنا + +174 +00:12:59,660 --> 00:13:05,240 +السوق نشوف قيمة السهم في السوق لنقر 40$ what do + +175 +00:13:05,240 --> 00:13:09,640 +you think ايش رأيكوا buy او sell نشريها للشركة و + +176 +00:13:09,640 --> 00:13:22,630 +لنبيها نشريها why is under priced نشريها صح buy + +177 +00:13:22,630 --> 00:13:27,050 +احنا بنعمل buy buy this stock because the + +178 +00:13:27,050 --> 00:13:30,450 +fundamental price is fifty dollarthe fundamental + +179 +00:13:30,450 --> 00:13:34,390 +it means the real price is fifty dollars however + +180 +00:13:34,390 --> 00:13:37,050 +the market price is forty dollars which is below + +181 +00:13:37,050 --> 00:13:42,070 +the expected price so it means the market + +182 +00:13:42,070 --> 00:13:45,310 +mechanisms or the investors try to buy this price + +183 +00:13:45,310 --> 00:13:48,630 +to go to this price يعني بده يحاول يشتري هذا السعر + +184 +00:13:48,630 --> 00:13:53,830 +حتى يساوي هذا السعر so this is under priced okay + +185 +00:13:53,830 --> 00:13:59,010 +if the opposite إذا كان العكس we calculate this by + +186 +00:13:59,010 --> 00:14:03,030 +fifty dollar but the .. so you understand this + +187 +00:14:03,030 --> 00:14:11,510 +واضح okay if .. اسمها ايه؟ قبل ما نبدأ احكي عادي + +188 +00:14:11,510 --> 00:14:19,970 +هتسأل لأنه هلأ اذا ب .. طالما ما في فرض مش سامي + +189 +00:14:19,970 --> 00:14:23,550 +الفصل السامي + +190 +00:14:23,550 --> 00:14:30,170 +اللي هم مابيشيوش على حساب خمسين على حساب أبريل، لأ + +191 +00:14:30,170 --> 00:14:35,050 +خليني يا بابا أقولك انتظر بسمعي شويّة، هلأ السعر في + +192 +00:14:35,050 --> 00:14:40,350 +السوق كام؟ أربعين دولار، السعر المتوقع خمسين + +193 +00:14:40,350 --> 00:14:47,040 +دولار، فهم السعر الحقيقي للسهم هو خمسين بس السعر في + +194 +00:14:47,040 --> 00:14:50,380 +السوق الآن بيبقى 40 دولار إذا سعره أقل من الحقيقة + +195 +00:14:50,380 --> 00:14:53,420 +صح فإنت بوجهك نظرة ايش راح تسوي راح تضلك تشتريه + +196 +00:14:53,420 --> 00:14:56,900 +لأنه بيصير supply كل ما بيصير demand كل ما بيصير + +197 +00:14:56,900 --> 00:15:01,200 +demand ايش بيصير في السعر بيرتفع طيب بيضلوا يرتفع + +198 +00:15:01,200 --> 00:15:03,660 +السعر لما يساوي الـ 50 دولار بيصير equilibrium + +199 +00:15:03,660 --> 00:15:08,240 +price بيصير سعر التوازن لما يصير سعر التوازن بيبطل + +200 +00:15:08,240 --> 00:15:13,500 +فيه trade طبعا وضحك هاي طب خلينا ناخد الـ the + +201 +00:15:13,500 --> 00:15:26,970 +opposite العكس if .. if B node is 55$ يعني حسبنا + +202 +00:15:26,970 --> 00:15:30,590 +السعر بناءً على الـ information economic و الـ + +203 +00:15:30,590 --> 00:15:34,350 +accounting information and we find it 50$ but when + +204 +00:15:34,350 --> 00:15:42,020 +we go to the market it was 55$ يعني under priced or + +205 +00:15:42,020 --> 00:15:46,380 +over priced over priced يعني أعلى من السعر الحقيقي + +206 +00:15:46,380 --> 00:15:51,840 +over priced so what people doing here what people + +207 +00:15:51,840 --> 00:15:56,220 +doing here they are selling هيبيعوا عشان السعر + +208 +00:15:56,220 --> 00:16:04,020 +ينزل لعند الـ fifty dollar they sell this okay so + +209 +00:16:04,020 --> 00:16:10,000 +the fundamental analysis الموضوع الأول أو الموضوع + +210 +00:16:10,000 --> 00:16:15,980 +الرئيسي للتحليل الأساسي هو تقدير السعر الأساسي + +211 +00:16:15,980 --> 00:16:22,700 +ومقارنة السعر الأساسي مع السعر السوقي إذا كان + +212 +00:16:22,700 --> 00:16:30,880 +السعر الأساسي أكثر أو أكثر من السعر المتوقع أو + +213 +00:16:30,880 --> 00:16:36,740 +السعر السوقي فهو تحت السعر، لذلك نشتري إذا كانت + +214 +00:16:36,740 --> 00:16:40,900 +تقريبا من قيمة السوق، فنقوم بالبيع لأنها تقريبا + +215 +00:16:40,900 --> 00:16:47,040 +من قيمة السوق، حسنًا؟ فهذا هو الأمر فقط + +216 +00:16:47,040 --> 00:16:54,700 +لكي أفهم ما يعني تحديث الأساس، نعم، + +217 +00:16:54,700 --> 00:17:00,750 +يبدو هكذا the main objective the other objectives + +218 +00:17:00,750 --> 00:17:03,470 +of the fundamental analysis is to try to find + +219 +00:17:03,470 --> 00:17:06,230 +things that are better than everyone else + +220 +00:17:06,230 --> 00:17:10,390 +estimates نحاول + +221 +00:17:10,390 --> 00:17:14,910 +نوجد طريقة حسابية + +222 +00:17:14,910 --> 00:17:19,010 +طريقة معادلات الناس الثانية مابقدروش يستخدموها to + +223 +00:17:19,010 --> 00:17:23,270 +estimate the price راحظوا احنا هنا there are + +224 +00:17:23,270 --> 00:17:27,130 +different methods to estimate the V notes الناس + +225 +00:17:27,130 --> 00:17:30,090 +بتسابقوا يشوفوا ايش الطريقة الصح لنا نعمل فيها الـ + +226 +00:17:30,090 --> 00:17:33,370 +V0 فهذه الـ techniques مرات احنا بنستخدم معادلات + +227 +00:17:33,370 --> 00:17:35,870 +رياضية is very complicated mathematical solution + +228 +00:17:35,870 --> 00:17:41,710 +to find out what is the V0 so the most important + +229 +00:17:41,710 --> 00:17:44,510 +thing is to find how we can estimate this using + +230 +00:17:44,510 --> 00:17:47,590 +advanced techniques advanced tools in order to + +231 +00:17:47,590 --> 00:17:52,070 +estimate the V0 and once we use this we have + +232 +00:17:52,070 --> 00:17:53,110 +better understanding + +233 +00:18:00,620 --> 00:18:06,660 +it's chapter لو جينا احنا حكينا قروبة قيمولها الـ + +234 +00:18:06,660 --> 00:18:13,040 +.. قيمولها الـ stock أساسي سهم لو جينا احنا بدنا + +235 +00:18:13,040 --> 00:18:20,620 +نقيم سهم سهم مثلا IBM what are the tools that you + +236 +00:18:20,620 --> 00:18:25,150 +can use ايش الـ tools اللي انتوا ممكن تستخدموها ممكن + +237 +00:18:25,150 --> 00:18:29,790 +نستخدم مثلا الـ average ممكن نستخدم الـ median ممكن + +238 +00:18:29,790 --> 00:18:34,210 +نستخدم sigma ممكن نستخدم الـ variance and these tools are + +239 +00:18:34,210 --> 00:18:38,430 +available for everyone هذه الـ tools متوفرة للكل so + +240 +00:18:38,430 --> 00:18:41,790 +it is not considered as advanced tool لا تعتبر + +241 +00:18:41,790 --> 00:18:46,010 +يعني هذه في ناس بيستخدموا تقنيات كثير متقدمة + +242 +00:18:46,010 --> 00:18:49,810 +رياضيا عشان يعملوا estimation للـ V notes بس هذه + +243 +00:18:49,810 --> 00:18:53,150 +التقنيات الكل بعرفها أي واحد أي طالب في الجامعة أي + +244 +00:18:53,150 --> 00:18:58,320 +واحد خلص ممكن يعملهالكن some professional people + +245 +00:18:58,320 --> 00:19:00,920 +الناس الـ professional they are using advanced tool + +246 +00:19:00,920 --> 00:19:08,820 +because they want to know which is stock perform + +247 +00:19:08,820 --> 00:19:11,900 +better than others يعني بيشوفوا السهم اللي بيعمل + +248 +00:19:11,900 --> 00:19:15,960 +أحسن من الآخرين لأنه لو احنا كلنا لو خمسين + +249 +00:19:15,960 --> 00:19:20,540 +investors في الـ store بيستخدموا the same tool they + +250 +00:19:20,540 --> 00:19:24,360 +will end up with the same results مظبوط ولا لأ؟ لو + +251 +00:19:24,360 --> 00:19:27,060 +خمسين شخص، خمسين مستثمر موجودين في السوق يستخدموا + +252 +00:19:27,060 --> 00:19:32,520 +نفس الـ tools، هيوصلوا لنفس النتيجة، إذا كان واحد + +253 +00:19:32,520 --> 00:19:37,880 +of them is more professional than others، إذا كان + +254 +00:19:37,880 --> 00:19:41,680 +واحد أكثر professional، أكثر احتراف من الآخرين، so + +255 +00:19:41,680 --> 00:19:45,330 +he or she may use different tools يعني ممكن يستخدم + +256 +00:19:45,330 --> 00:19:47,850 +different tools يعني خليني أعطيكم مثلا ممكن + +257 +00:19:47,850 --> 00:19:52,070 +يستخدم شغلة اسمها VAR، VAR مش الـ variance مش هذه + +258 +00:19:52,070 --> 00:19:59,490 +VAR is stand for Value at Risk, VAR + +259 +00:19:59,490 --> 00:20:03,150 +is stand for هذه الـ VAR شايفينها؟ هيك تكتبوها + +260 +00:20:03,150 --> 00:20:09,790 +Value at Risk, I'm not asking you to know what it + +261 +00:20:09,790 --> 00:20:14,310 +means, Value at Risk, but it is a technique helping + +262 +00:20:14,310 --> 00:20:19,810 +the professionals to know exactly what is the + +263 +00:20:19,810 --> 00:20:24,610 +actual performance of the supplies and these + +264 +00:20:24,610 --> 00:20:28,930 +techniques، حتى لو أنا قلت لكم this is VAR and ask + +265 +00:20:28,930 --> 00:20:31,630 +you to do it, you cannot do it because it needs a + +266 +00:20:31,630 --> 00:20:35,490 +high knowledge تحتاج لـ high knowledge معرفة عالية + +267 +00:20:35,490 --> 00:20:40,050 +و تستخدم تقنيات عالية كتير بالـ .. بالـ .. بالـ high + +268 +00:20:40,050 --> 00:20:45,430 +knowledge، لو واحد ثاني عنده knowledge أكثر ممكن + +269 +00:20:45,430 --> 00:20:50,330 +يستخدم Intrinsic Values طريقة + +270 +00:20:50,330 --> 00:20:54,150 +اسمها find the Intrinsic Values، طريقة أخرى عشان + +271 +00:20:54,150 --> 00:20:59,730 +نعرف احنا بالظبط السعر يعني أعطيكم مثال لو احنا + +272 +00:20:59,730 --> 00:21:08,210 +حكينا لكم بدنا نشوف القمر في الليل from your naked + +273 +00:21:08,210 --> 00:21:13,010 +eye، بعينكم المجردة، fine بتشوفوا و قول لكم اقصدوا في + +274 +00:21:13,010 --> 00:21:16,550 +القرار و أوكي القمر شكله هيك هيك، قولنا أوكي خدوا + +275 +00:21:16,550 --> 00:21:20,630 +هذا التليسكوب، هذا التليسكوب بيقرب لأشياء عشرة أو + +276 +00:21:20,630 --> 00:21:26,530 +ستة عشر، أقل ستة، فضلوا هتشوفوا أشياء أكثر، if I give + +277 +00:21:26,530 --> 00:21:31,090 +you another one which is measured for ten power + +278 +00:21:31,090 --> 00:21:36,150 +twelve يعني عشر أقل ستة عشر، هتشوفوا أكثر، to see + +279 +00:21:36,150 --> 00:21:38,710 +more details which is not available to people with + +280 +00:21:38,710 --> 00:21:43,060 +naked eyes، يعني شغلات بس لو واحد بيشوف بالعِين المجردة + +281 +00:21:43,060 --> 00:21:46,700 +just .. just the moon، some people say inside + +282 +00:21:46,700 --> 00:21:49,960 +the moon بيشوفوا داخل القمر، the same .. the same + +283 +00:21:49,960 --> 00:21:55,760 +thing، if you are applying new techniques and tools + +284 +00:21:55,760 --> 00:22:01,960 +فهذه الفكرة أنه في .. + +285 +00:22:01,960 --> 00:22:07,000 +if I .. زي ما احنا شوفت الـ butter + +286 +00:22:10,850 --> 00:22:15,310 +Some people they try to find poorly run things + +287 +00:22:15,310 --> 00:22:18,610 +that are not as bad as the market thinks، بعض + +288 +00:22:18,610 --> 00:22:27,430 +الناس، الناس العاديين، بيعتقدوا أن هذا السهم وضعه + +289 +00:22:27,430 --> 00:22:31,410 +سيء، but if you have extra analysis or in-depth + +290 +00:22:31,410 --> 00:22:34,210 +analysis، you see this is not as bad as the others + +291 +00:22:34,210 --> 00:22:40,490 +think، يعني مش كتير سيء زي ما الناس بيعتقدوا، فالناس + +292 +00:22:40,490 --> 00:22:42,930 +اللي بيشتغلوا بالـ fundamental analysis they have + +293 +00:22:42,930 --> 00:22:46,810 +their own tools which is unique and is not + +294 +00:22:46,810 --> 00:22:52,310 +available to others، هي مميزة ومش هتكون متوفرة + +295 +00:22:52,310 --> 00:22:56,410 +للآخرين اللي يقدروا أن هم إيش يستخدموا هذه الـ + +296 +00:22:56,410 --> 00:22:59,910 +tools، فهي هتساعدهم أول شيء تشوفوا مين السهم المليح + +297 +00:22:59,910 --> 00:23:04,470 +وكمان مين السهم اللي السوق بيعتقد أنه سيء بس هو مش + +298 +00:23:04,470 --> 00:23:06,350 +سيء، okay + +299 +00:23:10,790 --> 00:23:14,390 +فهذه مهمة الـ .. الـ .. الـ fundamental analysis يعني + +300 +00:23:14,390 --> 00:23:18,510 +احنا بنشوف مثلا سهم يعني أعطيكم مثلا ناس بيعتقدوا + +301 +00:23:18,510 --> 00:23:24,450 +أن ياهو is one of the best stock or Google، ناس + +302 +00:23:24,450 --> 00:23:27,410 +بيفهموا ياهو و جوجل، but if you have in-depth + +303 +00:23:27,410 --> 00:23:31,670 +analysis، ياهو or جوجل is the best، آه not the best + +304 +00:23:31,670 --> 00:23:36,600 +if you have in-depth analysis، if you have just + +305 +00:23:36,600 --> 00:23:40,820 +shallow analysis، shallow يعني معناها سطحي، إذا + +306 +00:23:40,820 --> 00:23:43,940 +عندنا shallow analysis تحليل سطحي which is + +307 +00:23:43,940 --> 00:23:47,660 +available for other people، so you cannot come up + +308 +00:23:47,660 --> 00:23:50,220 +with new things، but if you have in-depth analysis + +309 +00:23:50,220 --> 00:23:55,020 +with advanced tools، so you can see what is inside + +310 +00:23:55,020 --> 00:23:58,540 +ممكن تعرف what is inside، okay + +311 +00:24:03,810 --> 00:24:06,570 +فالـ fundamental analysis is much related to the + +312 +00:24:06,570 --> 00:24:08,670 +semi-strong hypothesis and I explained what it + +313 +00:24:08,670 --> 00:24:11,590 +means، semi-strong analysis، so it is fine، you can + +314 +00:24:11,590 --> 00:24:16,070 +use it in the in the in the fundamental in the + +315 +00:24:16,070 --> 00:24:20,510 +semi-strong market based on this understanding + +316 +00:24:20,510 --> 00:24:26,250 +بناء على الكلام هذا، بناء على الـ technical analysis + +317 +00:24:26,250 --> 00:24:28,570 +و الـ fundamental analysis we have two different + +318 +00:24:28,570 --> 00:24:33,320 +types of portfolio managers، بناء على فهمنا التحليل + +319 +00:24:33,320 --> 00:24:36,500 +الفني technical analysis والتحليل الأساسي الـ + +320 +00:24:36,500 --> 00:24:41,560 +fundamental analysis بيكون عندي نوعين من الـ + +321 +00:24:41,560 --> 00:24:45,000 +investors، we have active managers و في عندنا + +322 +00:24:45,000 --> 00:24:47,740 +passive managers، عندنا الـ active و عندنا الـ + +323 +00:24:47,740 --> 00:24:51,300 +managers، طبعا في عندي أنا هاي الملفين كده لما أنا + +324 +00:24:51,300 --> 00:24:56,740 +انسى أو مش ملفين أكثر من ملفين، هذه الملفات زي ما + +325 +00:24:56,740 --> 00:25:01,530 +انتم شايفين، هذه بالعربي يعني ممكن in your free + +326 +00:25:01,530 --> 00:25:05,530 +time and when you finish this course، مش الـ exam + +327 +00:25:05,530 --> 00:25:09,090 +this course، you can get benefit from reading these + +328 +00:25:09,090 --> 00:25:12,230 +files، يعني هي عندكم files مثلا بالتحليل الأساسي + +329 +00:25:12,230 --> 00:25:17,210 +شايفين اللي هو الـ fundamental analysis والتحليل + +330 +00:25:17,210 --> 00:25:19,330 +الفني اللي هو technical analysis، يعني لو احنا + +331 +00:25:19,330 --> 00:25:26,820 +إجينا للتحليل الأساسي، هتلاقي كلّه إيش عبارة عن تحليل + +332 +00:25:26,820 --> 00:25:33,800 +اقتصادي و تحليل مالي، يعني خليني أنا أورجيكم فيه، هذا + +333 +00:25:33,800 --> 00:25:39,900 +يعني بالـ .. بالـ free time تبعكم، اتحاولوا يعني بعد + +334 +00:25:39,900 --> 00:25:43,200 +اللي ما تنهوا المحاضرات مش الانتحارات، والفصل و + +335 +00:25:43,200 --> 00:25:44,280 +كذا، آه + +336 +00:25:47,610 --> 00:25:51,630 +يعني شوفوا التحليل الأساسي كلّه يعني بيستخدموا + +337 +00:25:51,630 --> 00:25:55,090 +معادلات، يعني مثلا هان مكرر الأرباح اللي هو الـ P-E + +338 +00:25:55,090 --> 00:25:58,790 +ratio، الـ P-E ratio أنا أعطيتكم الـ P-E ratio قبل + +339 +00:25:58,790 --> 00:26:05,010 +ثلاثة .. يعني chapter two و chapter three فاكرين؟ لأ + +340 +00:26:05,010 --> 00:26:07,510 +تفرجوا الـ P-E ratio جاي في سؤال أنتم هان فيه على + +341 +00:26:07,510 --> 00:26:13,290 +فكرة الـ P-E ratio، الـ P-E ratio أخذناها لما كنا + +342 +00:26:13,290 --> 00:26:18,370 +نحاول نقرأ الـ stocks و الـ bonds، أكيد مش تعرفوا هذه + +343 +00:26:18,370 --> 00:26:23,510 +correct the answers، multiple choice و الصح و غلط و + +344 +00:26:23,510 --> 00:26:26,590 +أشياء مثلها، التحليل المالي مثلا شوفوا التحليل + +345 +00:26:26,590 --> 00:26:30,310 +المالي مهم بالـ .. بالـ fundamental analysis يعني + +346 +00:26:30,310 --> 00:26:33,850 +هذا إن شاء الله في الـ free time you can read this + +347 +00:26:33,850 --> 00:26:37,410 +خليني + +348 +00:26:37,410 --> 00:26:41,310 +بس أخلص الصفحة هذه، active or passive management + +349 +00:26:41,310 --> 00:26:47,390 +احنا حكينا المرة الفاتة في chapter two، the active + +350 +00:26:47,390 --> 00:26:54,650 +management think that the market is not efficient + +351 +00:26:56,200 --> 00:26:59,240 +and there is a lot of mispricing، so they depend on + +352 +00:26:59,240 --> 00:27:02,960 +the mispricing to correct the inefficiency، يعني هم + +353 +00:27:02,960 --> 00:27:05,360 +دورهم بيخلوا الـ market efficient، هو أصلا الـ market + +354 +00:27:05,360 --> 00:27:10,160 +مش efficient لكن the .. the contribution of the + +355 +00:27:10,160 --> 00:27:12,740 +active managements or the active managers make the + +356 +00:27:12,740 --> 00:27:16,340 +market efficient، يعني تدخلهم هو بيخلي، لأنه مش + +357 +00:27:16,340 --> 00:27:21,420 +ذاكر لما احنا حكينا the prices deviate from their + +358 +00:27:21,420 --> 00:27:26,410 +fundamental، بتقول احنا أخذنا الـ risk and return + +359 +00:27:26,410 --> 00:27:30,970 +وحكينا the prices should be on the security market + +360 +00:27:30,970 --> 00:27:35,350 +line، sometimes there is mispricing، so the role of + +361 +00:27:35,350 --> 00:27:38,330 +active management is to correct this and making + +362 +00:27:38,330 --> 00:27:40,870 +the price or making the stocks to be on the line + +363 +00:27:40,870 --> 00:27:45,850 +okay، هذا بيسموهم الـ active management، this is an + +364 +00:27:45,850 --> 00:27:49,750 +expensive strategy، هذي expensive strategy بتكلفهم + +365 +00:27:49,750 --> 00:27:52,830 +كتير، why? because they .. they want to collect a + +366 +00:27:52,830 --> 00:27:57,330 +fundamental information to know which is the + +367 +00:27:57,330 --> 00:28:00,910 +inefficient prices or which stock is inefficient + +368 +00:28:00,910 --> 00:28:06,470 +or which stock is mispriced، و أي سهم هو عليه + +369 +00:28:06,470 --> 00:28:08,670 +mispriced يعني مش مسعر بطريقة صحيحة + +370 +00:28:11,650 --> 00:28:15,130 +because they spend a lot of money on collecting + +371 +00:28:15,130 --> 00:28:18,170 +fundamental and private information، so it is not + +372 +00:28:18,170 --> 00:28:21,830 +suitable for the small investors، يعني مش كويسة على + +373 +00:28:21,830 --> 00:28:24,150 +small investors، يعني الواحد مستخدم اللي عنده one + +374 +00:28:24,150 --> 00:28:27,100 +hundred dollar، عنده مئة دولار أو ألف دولار يروح + +375 +00:28:27,100 --> 00:28:30,040 +يجمع معلومات و .. and it cost for him or for her + +376 +00:28:30,040 --> 00:28:34,200 +so it is not suitable for them مش كتير مناسبة لهم + +377 +00:28:34,200 --> 00:28:37,620 +هذه مناسبة لمين is suitable only for large + +378 +00:28:37,620 --> 00:28:40,800 +portfolios يعني لو واحد عنده محفظة خمس مليون ولا + +379 +00:28:40,800 --> 00:28:45,800 +ميت مليون دولار and invest one percent يعني لو صرف + +380 +00:28:45,800 --> 00:28:49,800 +ألف دولار ولا ميت ألف دولار it.. it deserves + +381 +00:28:49,800 --> 00:28:53,870 +تستحق لإيجمع معلومات ويعمل تحليل The passive + +382 +00:28:53,870 --> 00:28:58,130 +managers think the market is efficient يعني + +383 +00:28:58,130 --> 00:29:00,790 +بيعتقدوا أن the market is efficient all of the + +384 +00:29:00,790 --> 00:29:05,610 +stock is located on the security market line كل الأسهم + +385 +00:29:05,610 --> 00:29:08,390 +بتقع على خط السوق and the market is + +386 +00:29:08,390 --> 00:29:13,510 +efficient and because of this no attempt to + +387 +00:29:13,510 --> 00:29:17,550 +outsmart the market يعني ما تكونوش شاطرين كتير كأنه + +388 +00:29:17,550 --> 00:29:20,590 +الـ .. الـ .. الـ .. الـ people believe on the passive + +389 +00:29:20,590 --> 00:29:22,710 +management بيعتقدوا أنه the market is efficient + +390 +00:29:22,710 --> 00:29:25,950 +they just only to invest on the stocks that + +391 +00:29:25,950 --> 00:29:28,770 +located in the .. in the market on the security + +392 +00:29:28,770 --> 00:29:31,890 +market line فحاولوا يوجدوا تنويعة موجودة على خط + +393 +00:29:31,890 --> 00:29:37,550 +السوق don't be outsmart ما تكونش تفهم كتير because + +394 +00:29:37,550 --> 00:29:42,690 +the market outsmart others يعني السوق أفهم وأشطر + +395 +00:29:42,690 --> 00:29:48,040 +من الناس كلها okay So they accept the efficient + +396 +00:29:48,040 --> 00:29:53,020 +market hypothesis AMH, they invest in the index + +397 +00:29:53,020 --> 00:29:57,240 +funds and I explain this because the index funds + +398 +00:29:57,240 --> 00:30:00,620 +اللي هو المؤشرات السوق because it includes only + +399 +00:30:00,620 --> 00:30:05,160 +the best stocks يعني المؤشرات اللي أسهم زي مؤشر + +400 +00:30:05,160 --> 00:30:09,620 +Dow Jones وNasdaq وNikkei ومؤشر New York Stock + +401 +00:30:09,620 --> 00:30:15,080 +Exchange ومؤشر FTSE 100 وهذا شلحته أظن بشتر two أو + +402 +00:30:15,080 --> 00:30:19,850 +three and one of the characteristics is very low + +403 +00:30:19,850 --> 00:30:23,070 +cost you don't need to collect information بس + +404 +00:30:23,070 --> 00:30:26,970 +أنتوا خدوا الأسهم لإنه دايما في كل يوم افتحوا + +405 +00:30:26,970 --> 00:30:30,370 +الناشرة الاقتصادية أو شيء فبحكوكوا the best one + +406 +00:30:30,370 --> 00:30:34,990 +hundred companies أفضل مئة شركة خلاص so you don't + +407 +00:30:34,990 --> 00:30:38,950 +need to look for who is the best because the best + +408 +00:30:38,950 --> 00:30:42,610 +is already known so just channel your fund to the + +409 +00:30:42,610 --> 00:30:47,680 +best okay So this is the active and passive + +410 +00:30:47,680 --> 00:30:48,040 +management diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/SKWjWg0aL4w_postprocess.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/SKWjWg0aL4w_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..09aefa653e2e5461f09676f1e95be231966d84f1 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/SKWjWg0aL4w_postprocess.srt @@ -0,0 +1,1784 @@ +1 +00:00:21,910 --> 00:00:26,790 +بسم الله الرحمن الرحيم احنا هنبدأ بال .. بال asset + +2 +00:00:26,790 --> 00:00:30,770 +classes بالقائمة ثالثة انا ما اعتقد بال asset + +3 +00:00:30,770 --> 00:00:35,310 +classes و المرة الفاترة كنا نحكي في ال bankers + +4 +00:00:35,310 --> 00:00:40,430 +acceptance okay و .. و ال bankers acceptance هي + +5 +00:00:40,430 --> 00:00:44,110 +كلها بال money markets حكينا ال bankers acceptance + +6 +00:00:44,110 --> 00:00:49,150 +و ال commercial papers حكينا ال treasury bills و + +7 +00:00:49,150 --> 00:00:56,680 +.. و إيش كمانو certificate of deposits شهادات + +8 +00:00:56,680 --> 00:01:00,600 +إيداع okay فى حد مش فاهم إيش من هدول الأربعة اللى + +9 +00:01:00,600 --> 00:01:06,020 +حاكيناهم okay bankers acceptance واضحة طيب هلا + +10 +00:01:06,020 --> 00:01:09,300 +نحكي بال euro dollars so what it means euro + +11 +00:01:09,300 --> 00:01:15,020 +dollars euro dollars is any dollar traded outside + +12 +00:01:15,020 --> 00:01:18,460 +the united states is considered as a euro dollar + +13 +00:01:19,110 --> 00:01:21,610 +يعني أي دولار يتم تداوله خارج الولايات المتحدة + +14 +00:01:21,610 --> 00:01:27,930 +الأمريكية هو يعتبر euro dollar okay in the same + +15 +00:01:27,930 --> 00:01:34,030 +vein في نفس السياق any yen for instance traded + +16 +00:01:34,030 --> 00:01:39,930 +outside Japan is considered as euro yen يعني حتى + +17 +00:01:39,930 --> 00:01:41,890 +ال yen اللي يتم تداوله ال yen الياباني العملة + +18 +00:01:41,890 --> 00:01:45,770 +اليابانية أي yen ياباني يتم تداوله خارج اليابان + +19 +00:01:45,770 --> 00:01:52,930 +بنسميه euro yenSo why investors prefer to trade in + +20 +00:01:52,930 --> 00:01:58,330 +dollar of the United States لما نحكي of .. of .. + +21 +00:01:58,330 --> 00:02:02,470 +I'm using of not of .. of .. of the United States + +22 +00:02:02,470 --> 00:02:05,230 +it means outside the United States So why + +23 +00:02:05,230 --> 00:02:08,830 +investors prefer to use or to trade in dollar of + +24 +00:02:08,830 --> 00:02:12,370 +the United States So they have two options to + +25 +00:02:12,370 --> 00:02:14,870 +trade or to invest the dollar inside the United + +26 +00:02:14,870 --> 00:02:19,090 +States or outside the United Statesbecause of the + +27 +00:02:19,090 --> 00:02:23,950 +united states giving them higher return يعني خارج + +28 +00:02:23,950 --> 00:02:26,010 +الولايات المتحدة الأمريكية لما هم بيستثمروا في + +29 +00:02:26,010 --> 00:02:29,510 +الدولار خارج الولايات المتحدة الأمريكية بيعطيهم + +30 +00:02:29,510 --> 00:02:33,330 +عائد أعلى so this is why investors prefer to + +31 +00:02:33,330 --> 00:02:36,550 +invest in dollar of the united states rather to + +32 +00:02:36,550 --> 00:02:41,650 +invest it inside the united states إذن أي عملة يتم + +33 +00:02:41,650 --> 00:02:48,660 +تداولها خارج الدولةبتاعتها بنسميها euro something + +34 +00:02:48,660 --> 00:02:54,760 +يعني مثلا احنا هأعطيلكم مثال الين الين .. الين هي + +35 +00:02:54,760 --> 00:02:58,100 +الرمزة الين الين الياباني okay الين الياباني لما + +36 +00:02:58,100 --> 00:03:01,540 +أنا بداول الين الياباني خارج اليابان فبنسميه اش + +37 +00:03:01,540 --> 00:03:04,820 +euro yen okay + +38 +00:03:06,570 --> 00:03:10,310 +ليش احنا استخدمنا كلمة euro ما استخدمناش مثلا كلمة + +39 +00:03:10,310 --> 00:03:13,930 +أخرى because the most of trade is coming from + +40 +00:03:13,930 --> 00:03:17,770 +European countries يعني أغلب ال .. ال .. الاتجارات + +41 +00:03:17,770 --> 00:03:21,870 +و الاستثمارات بتتم في الولايات .. في أوروبا طبعا + +42 +00:03:21,870 --> 00:03:26,530 +في financial hub في العالم ال financial hub في + +43 +00:03:26,530 --> 00:03:29,750 +العالم يعني مناطق الاستثمار في العالم في عندنا + +44 +00:03:29,750 --> 00:03:35,490 +Frankfurt عارفين Frankfurt؟ وين Frankfurt؟Okay هذا + +45 +00:03:35,490 --> 00:03:40,490 +.. هذا بيعتبر تاني hub في العالم و في عندنا كمان + +46 +00:03:40,490 --> 00:03:44,090 +ال wall street, وين ال wall street؟ United States + +47 +00:03:44,090 --> 00:03:47,810 +و في عندنا كمان كانت البحرين بس اللحظة هاي صارت + +48 +00:03:47,810 --> 00:03:51,670 +دبي بيعتبر ثالث رابع hub financial hub في العالم + +49 +00:03:51,670 --> 00:03:57,400 +okay و عندنا كمان اللي هو Tokyoهذه كمان تدخل علينا + +50 +00:03:57,400 --> 00:04:00,520 +أربع financial hub في ال .. في ال international أو + +51 +00:04:00,520 --> 00:04:05,140 +في ال .. في العالم كله فهدول ال financial hubs are + +52 +00:04:05,140 --> 00:04:09,820 +using currencies hard currencies to invest in + +53 +00:04:09,820 --> 00:04:13,880 +overall the world بيستخدموا عملات صعبة يعني for + +54 +00:04:13,880 --> 00:04:17,740 +instance على سبيل المثال في ألمانيا مثلا بيستخدموا + +55 +00:04:17,740 --> 00:04:22,940 +عظم العملات الصعبة مثل اليندي الياباني okay يعتبر + +56 +00:04:22,940 --> 00:04:28,470 +عملة صعبة مثل ال euroOkay ال .. يعتبر عاملة صعبة + +57 +00:04:28,470 --> 00:04:33,170 +الدولار أكيد عاملة صعبة ال bound كمان يعتبر عاملة + +58 +00:04:33,170 --> 00:04:36,710 +صعبة طب لو احنا حكينا ال .. ال bound اللي هو + +59 +00:04:36,710 --> 00:04:41,470 +هنسميه euro bound اذا احنا بنستخدم ال bound of the + +60 +00:04:41,470 --> 00:04:46,650 +.. of the UK لأن مين اللي بصدر ال bound؟ ال bound + +61 +00:04:46,650 --> 00:04:49,720 +يعني الإجناء السرلينيOkay the UK اللي هو the + +62 +00:04:49,720 --> 00:04:54,040 +British .. the .. the UK united kingdom so the + +63 +00:04:54,040 --> 00:04:58,980 +united kingdom traded in the .. in the pound so + +64 +00:04:58,980 --> 00:05:02,460 +any pound traded of the UK is considered as euro + +65 +00:05:02,460 --> 00:05:08,120 +pound اللي هو السترليني بيتم تعامل خارج ال .. + +66 +00:05:08,120 --> 00:05:13,540 +الدولة تبعتهم طبعا احنا حكينا ليش؟ ايش السبب؟ عدوا + +67 +00:05:13,540 --> 00:05:14,000 +ليه ليش؟ + +68 +00:05:18,090 --> 00:05:21,850 +اه الاستثمار بيكون خارج الدولة أعلى العائد من داخل + +69 +00:05:21,850 --> 00:05:27,350 +الدولة يعني مثلا لو أنا أستثمر في الدولار في داخل + +70 +00:05:27,350 --> 00:05:30,030 +الولايات المتحدة الأمريكية في united states ممكن + +71 +00:05:30,030 --> 00:05:34,770 +يعطيني مثلا three percent لكن أستثمر الدولار of + +72 +00:05:34,770 --> 00:05:37,470 +the united states of the united states ممكن يعطيني + +73 +00:05:37,470 --> 00:05:41,630 +four percent okay high return and in the same vein + +74 +00:05:41,630 --> 00:05:44,890 +high risk زي ما بنحكي احنا في عندنا high return + +75 +00:05:44,890 --> 00:05:49,360 +كمان في عندنا high riskOkay؟ هذا بالنسبة لليورو + +76 +00:05:49,360 --> 00:05:58,560 +دولار طبعا يتم إصدار أدوات مالية بهذه العملات خارج + +77 +00:05:58,560 --> 00:06:01,200 +الولايات المتحدة الأمريكية يعني ممكن أعطيكوا مثال + +78 +00:06:01,200 --> 00:06:04,740 +ممكن البنك ال .. البنك المركزي الإنجليزي مثلا يروح + +79 +00:06:04,740 --> 00:06:10,700 +يصدر سندات بال .. بالسترليني عفوا بالدولار طبعا هو + +80 +00:06:10,700 --> 00:06:14,160 +بنك إنجليزي فالمفروض يصدر سندات بالإياش بالسترليني + +81 +00:06:14,160 --> 00:06:18,220 +فبروح يصدرها بالإياش بالدولارفإيش بنسميه في الحالة + +82 +00:06:18,220 --> 00:06:24,240 +هذا؟ بنسميها إيش؟ euro bond أو dollar bond سندات + +83 +00:06:24,240 --> 00:06:29,920 +بالدولار وهذه طبعا برضه بتضالها في ال euro dollar + +84 +00:06:29,920 --> 00:06:33,640 +bonds euro dollar bonds يعني إما إحنا ال bonds + +85 +00:06:33,640 --> 00:06:36,800 +نصدره + +86 +00:06:36,800 --> 00:06:41,380 +بالدولار outside or of the united states of the + +87 +00:06:41,380 --> 00:06:45,380 +united states إيش بنسميه؟ بسميه euro dollar + +88 +00:06:47,880 --> 00:06:53,560 +bond هلأ إذا كان خارج ال united states نسميه euro + +89 +00:06:53,560 --> 00:06:58,540 +dollar bond طب لو كان .. يعني مثلا احنا أصدرنا ال + +90 +00:06:58,540 --> 00:07:02,420 +.. عادة مين بصدر السندات بالدولار؟ ال united + +91 +00:07:02,420 --> 00:07:06,940 +states طب لو أحنا أصدرنا سندات أمريكية خارج + +92 +00:07:06,940 --> 00:07:09,160 +الولايات المتحدة الأمريكية يعني البنك المركزي + +93 +00:07:09,160 --> 00:07:12,960 +الإنجليزي راح أصدر سندات بالدولار + +94 +00:07:14,290 --> 00:07:18,790 +فبنسمي السندات هذه نسميها euro dollar bond نعطي + +95 +00:07:18,790 --> 00:07:23,530 +مثال تاني لو حكينا مثلا ال .. ال .. ال ASB عارفين + +96 +00:07:23,530 --> 00:07:27,270 +ASB؟ ضروري هدول المصطلحات تكون عندكم معرفة فيها + +97 +00:07:27,270 --> 00:07:30,270 +لإنه بتتكرر كتير بالأخبار في الجزيرة بال CNBC + +98 +00:07:30,270 --> 00:07:34,350 +بيحكوش مثلا the central bank of Europe لإنه it + +99 +00:07:34,350 --> 00:07:36,430 +takes time لما بيحكوها ال central bank of Europe + +100 +00:07:36,430 --> 00:07:41,390 +أخدت ثانية من وقت المزيد عشان يحكيها فبحكي ASB ال + +101 +00:07:41,390 --> 00:07:44,840 +ASB اللي هي بيسميها ال European Central Bankالبنك + +102 +00:07:44,840 --> 00:07:47,680 +المركزي الأوروبي فهلأ البنك المركزي الأوروبي راح + +103 +00:07:47,680 --> 00:07:54,320 +أصدر bonds مثلا بال .. مثلا بال yen فشو روح نسميها + +104 +00:07:54,320 --> 00:08:02,000 +في الحالة هذه؟ روح نسميها euro يورو يند bond هي + +105 +00:08:02,000 --> 00:08:06,220 +التسمية بتاعتها تصير فبصير أنه البنك المركزي روح + +106 +00:08:06,220 --> 00:08:13,780 +يصدر عملة يصدر سندات بعملة أخرى ولكن هذا نادرغالبا + +107 +00:08:13,780 --> 00:08:18,760 +.. غالبا الدول بتصدر بالدولار، غالبا الدولار هو + +108 +00:08:18,760 --> 00:08:25,060 +متعرف عليه و بستاني بيسموه euro dollar bonds okay + +109 +00:08:25,060 --> 00:08:31,040 +any question؟ أي سؤال على ال euro dollar؟ مضحك + +110 +00:08:31,040 --> 00:08:38,960 +اظنها ال euro dollar، في حد مش واضح عنده؟ rebounds + +111 +00:08:38,960 --> 00:08:43,730 +and reversesrebours and reverses short term loan + +112 +00:08:43,730 --> 00:08:47,710 +backed by government securities في حد تعرف what it + +113 +00:08:47,710 --> 00:08:54,970 +means? اتفاقية إعادة الشرائع عارفين كيف هذا بتتم؟ + +114 +00:08:54,970 --> 00:08:58,650 +اللي + +115 +00:08:58,650 --> 00:09:02,210 +هو rebours اللي هو repurchase agreement هذه + +116 +00:09:02,210 --> 00:09:08,150 +اختصارها rebours اختصارها repurchase agreement + +117 +00:09:13,220 --> 00:09:19,900 +purchase agreements طيب + +118 +00:09:19,900 --> 00:09:23,660 +how + +119 +00:09:23,660 --> 00:09:27,360 +we use repurchase agreements؟ كيف احنا بستخدم ال + +120 +00:09:27,360 --> 00:09:31,320 +repurchase agreements؟ and why we use this؟ و ليش + +121 +00:09:31,320 --> 00:09:40,580 +احنا بستخدمها؟ في حد عنده فكرة؟ طيب + +122 +00:09:41,760 --> 00:09:45,240 +نعطي مثال بسيط و بعدين نطبقها how the investors + +123 +00:09:45,240 --> 00:09:50,000 +use it بس عشان تفهم المثال أنا هي معايا موبايل + +124 +00:09:50,000 --> 00:09:54,620 +okay بدي + +125 +00:09:54,620 --> 00:09:58,700 +فلوس بس ليوم واحد I don't have any money ماعنديش + +126 +00:09:58,700 --> 00:10:03,180 +أي فلوس بس معايا ال mobile تبعي فإيش ال option مش + +127 +00:10:03,180 --> 00:10:09,480 +أرهنه أبيعه أبيعه بعدين أشتريه okay هلأ ال mobile + +128 +00:10:12,740 --> 00:10:17,920 +الموبايل نفترض ثمن و ميت دولار ثمن و كام؟ ميت + +129 +00:10:17,920 --> 00:10:20,920 +دولار طبعا انا مابدي أدى يعني انا معايا الموبايل + +130 +00:10:20,920 --> 00:10:26,440 +تبعى فبروح بحكي مين يشتري مني الموبايل فبيش بحكي + +131 +00:10:26,440 --> 00:10:32,640 +واحد كأنا بشتري منك فبيعت الموبايل فلما بعت + +132 +00:10:32,640 --> 00:10:37,540 +الموبايل صار عندى ميت دولار في جيبتي plus and I + +133 +00:10:37,540 --> 00:10:41,500 +don't have mobileركزوا في المثال I don't have + +134 +00:10:41,500 --> 00:10:49,380 +mobile طيب ال + +135 +00:10:49,380 --> 00:10:53,780 +100 دولار انا لان معيش ال 100 دولار هذه بس بكرا في + +136 +00:10:53,780 --> 00:10:57,400 +صاحبي بده ي .. انا بده منه فلوس داينه و حكي اللي + +137 +00:10:57,400 --> 00:11:01,640 +بكرا بجيبلكيهم فتاني يوم جابلي ال 100 دولار تاني + +138 +00:11:01,640 --> 00:11:07,600 +يوم اياش جابلي ال 100 دولار فهدي ال 100 دولار صار + +139 +00:11:07,600 --> 00:11:12,420 +عندى 100 دولارجابليها صديقي فانا بدأ أسد مين؟ بدأ + +140 +00:11:12,420 --> 00:11:18,220 +أسد عيد شراء ال mobile عاد شراء ال mobile روحت على + +141 +00:11:18,220 --> 00:11:20,980 +السوق بدأ أشر ال mobile زي ال mobile اللي أنا + +142 +00:11:20,980 --> 00:11:25,200 +معايا إيش قالولي لأ؟ هذا بمية و عشرين دولار، + +143 +00:11:25,200 --> 00:11:29,640 +مظبوط؟ مش هذا اللي بيصير معاكم؟ أنا خسرت كام في + +144 +00:11:29,640 --> 00:11:34,660 +هالحالة؟ عشرين دولار في في السوق في ال .. بال + +145 +00:11:34,660 --> 00:11:39,690 +financial markets لأنه أنا لما روحت على ميةبيعته ب + +146 +00:11:39,690 --> 00:11:43,330 +100 و لما روحت اعمال اعيد شرائه لان انا بدي .. بدي + +147 +00:11:43,330 --> 00:11:46,730 +mobile دفعت 120 فانا خسرت 20 دولار في الحالة هذه + +148 +00:11:46,730 --> 00:11:51,830 +اه في في الأسواق المالية بيعملولي بيعملولي + +149 +00:11:51,830 --> 00:11:57,790 +services خدمات بيحكولي okay if you need 100$ this + +150 +00:11:57,790 --> 00:12:02,630 +is fine بياخدوا ال mobile و في نفس اللحظة اللي انا + +151 +00:12:02,630 --> 00:12:06,350 +ببيع فيها ال mobile بقى اتفق على اعادة شراء في نفس + +152 +00:12:06,350 --> 00:12:12,180 +اللحظةOkay يعني بتفق أنه أنا باعته بمية و بحكي طب + +153 +00:12:12,180 --> 00:12:15,820 +أنا لبكرا بدأ أشري كام أدفع .. كام بدأ أدفع + +154 +00:12:15,820 --> 00:12:20,980 +فبيعطوني .. بيعطوني بيحكولي okay مية و واحد دولار + +155 +00:12:20,980 --> 00:12:26,700 +طبعا شراق + +156 +00:12:26,700 --> 00:12:34,800 +مية دولار تابعوا معايا شراق عفوا بدينا ببيع .. بيع + +157 +00:12:34,800 --> 00:12:40,630 +مية دولار بيعت ال mobileو في نفس اللحظة بدي إيش؟ + +158 +00:12:40,630 --> 00:12:51,170 +أشري شراء بكم 101 دولار نفس + +159 +00:12:51,170 --> 00:12:55,710 +اللحظة نفس الاشي نفس اللي سوناها بس بروح ببيع ال + +160 +00:12:55,710 --> 00:12:58,910 +mobile مع نفس الشخص بقوله أنا بدي أشري بكرا منك + +161 +00:12:58,910 --> 00:13:02,850 +بدي أشري يعني أنا بيعطي اللحظة هذه و في نفس اللحظة + +162 +00:13:02,850 --> 00:13:06,930 +بدي أشري بكرا منه بس الاتفاق بيكون في إيش؟ في نفس + +163 +00:13:06,930 --> 00:13:14,330 +الوقتوبالتالي في نفس الوقت بيحكيله okay انا بشري + +164 +00:13:14,330 --> 00:13:22,530 +منك ب 100 دولار و بكرا ببيعكيا ب 101 okay طيب في + +165 +00:13:22,530 --> 00:13:26,630 +صفة انه انا كام خسرت في اللحظة دولار واحد لو انا + +166 +00:13:26,630 --> 00:13:30,770 +مادخلتش بال .. بال .. ال repos بخسر عشرين دولار + +167 +00:13:30,770 --> 00:13:38,320 +طيب لسه بنكمل هان لما الدولار 100 دولارلما أنا بقت + +168 +00:13:38,320 --> 00:13:43,140 +ال .. ال .. ال mobile تمام حصلت على cash مية دولار + +169 +00:13:43,140 --> 00:13:46,760 +cash مكرا + +170 +00:13:46,760 --> 00:13:55,500 +هرجع ال cash، مظبوط؟ طيب طبعا هرجع ال cash و زيادة + +171 +00:13:55,500 --> 00:14:00,070 +عليهم كام؟دولار واحد هينخفض من الرصيد تبع دولار + +172 +00:14:00,070 --> 00:14:03,310 +واحد بيجيلي الرجال بيحكي له ليش هاد دوشة هذه مية و + +173 +00:14:03,310 --> 00:14:06,730 +مية لأ خلينا احنا بدل ما ندفع على مية دولار و مية + +174 +00:14:06,730 --> 00:14:11,490 +و واحد لأ نحسب شغله اسمه repo rate نحسب ايش? repo + +175 +00:14:11,490 --> 00:14:15,970 +rate يعني نسبة بدون ما احكيلك هذا بمية و هذا + +176 +00:14:15,970 --> 00:14:19,970 +بميتين لأ انا بعطيك ال cash اللي انت بدكيها okay و + +177 +00:14:19,970 --> 00:14:24,850 +بحسبلك عليها repo rate هذا الرقم ايش بيسموه بيسموه + +178 +00:14:24,850 --> 00:14:30,350 +repo rateطبعا هو بدل ما هو ناقص واحد بيحولونا نسبة + +179 +00:14:30,350 --> 00:14:35,830 +مقوية بيحولونا نسبة مقوية واحد في المية طبعا واحد + +180 +00:14:35,830 --> 00:14:40,530 +في المية من قيمة ايش؟ من قيمة المبنى يعني مثلا + +181 +00:14:40,530 --> 00:14:44,230 +واحد في المية لو كان سعر ال mobile مية دولار نضرب + +182 +00:14:44,230 --> 00:14:48,870 +واحد في المية ضرب مية و سوى ايش؟ واحد لو كان قيمة + +183 +00:14:48,870 --> 00:14:54,240 +ال mobile ميتين دولار نضرب واحد في الميةبتساوى + +184 +00:14:54,240 --> 00:14:58,620 +اتنين واحدة كذا طيب هذا احنا بالمثال ال .. ال .. + +185 +00:14:58,620 --> 00:15:02,280 +ال .. عشان تفهموا الأمور كيف تمشي طيب the .. the + +186 +00:15:02,280 --> 00:15:06,960 +banks .. هاه؟ لأ + +187 +00:15:06,960 --> 00:15:10,940 +احنا في نفس اللحظة هتم الاتفاق اه يعني لأ نفس + +188 +00:15:10,940 --> 00:15:13,900 +اللحظة انا ابيع ال mobile و في نفس اللحظة اشتريه + +189 +00:15:13,900 --> 00:15:17,980 +بكرا طبعا ليش احنا السبب ان احنا استخدمنا الطريقة + +190 +00:15:17,980 --> 00:15:21,380 +هذه لأن انا استخدمت ال mobile اكم يوم انا استخدمت + +191 +00:15:21,380 --> 00:15:25,940 +الطريقة هذه اكم يومover the night ايه سميها over + +192 +00:15:25,940 --> 00:15:29,680 +the night يعني بس مرور الليل طب نعطي مثال how the + +193 +00:15:29,680 --> 00:15:33,360 +investors use this كيف المستثمرين بيستخدموا الكلام + +194 +00:15:33,360 --> 00:15:37,840 +هذا نعطيكوا مثال ومثال هذا تستخدم البنوك واقعي + +195 +00:15:37,840 --> 00:15:48,040 +okay طيب + +196 +00:15:48,040 --> 00:15:54,090 +لو عندنا مثال البنك العربيعارفين ال bank العربي + +197 +00:15:54,090 --> 00:16:02,370 +اه؟ Arab Bank ال Arab Bank موجود عنده cash طلعوا + +198 +00:16:02,370 --> 00:16:10,010 +ال asset عشرة مليون دولار asset بال cash tomorrow + +199 +00:16:10,010 --> 00:16:20,430 +اللي هو بكرا محتاجين يدفعوا رواتب للسلطة رواتب + +200 +00:16:20,430 --> 00:16:25,450 +السلطة بتدفع بالشكل ولا بالدولار؟بالشكل okay اذا + +201 +00:16:25,450 --> 00:16:30,630 +ال .. البنك العرب شو بحتاج عنده عشرة مليون دولار + +202 +00:16:30,630 --> 00:16:37,110 +بديوا يحولهم لشكل okay اذا tomorrow اتبعوا معايا + +203 +00:16:37,110 --> 00:16:44,490 +بالمثال tomorrow the Arab bank needs okay شكل + +204 +00:16:44,490 --> 00:16:51,230 +بحتاج شكل عشانيعطي الموظفين راتبهم طب عنده two + +205 +00:16:51,230 --> 00:16:54,390 +options زي ما حكينا فكرة ال mobile يروح يبيع ال + +206 +00:16:54,390 --> 00:16:59,030 +mobile okay و يستنى بينما يعطي الموظفين راتبهم + +207 +00:16:59,030 --> 00:17:02,090 +بعدين بيجيلوا فلوس و بروح بشتري الدولارات كام مرة + +208 +00:17:02,090 --> 00:17:06,750 +و هذه حكينا فيها ايش فيها مخاطر هيدفع فلوس كتير + +209 +00:17:06,750 --> 00:17:10,750 +خلينا نمشي نشوف كيف ال two options ممشوا مع بعض + +210 +00:17:10,750 --> 00:17:17,670 +ناخد ال option oneoption one option one بلي يحول + +211 +00:17:17,670 --> 00:17:23,630 +العشرة مليون لكم لشكل رأسه يقول العشرة مليون ضرب + +212 +00:17:23,630 --> 00:17:31,610 +تلاتة فاصلة واحد وسبعين او تلاتة فاصلة سبعين حكى + +213 +00:17:31,610 --> 00:17:36,110 +okay فراحه لما حولهم كام تلاتة فاصلة سبعين ضرب + +214 +00:17:36,110 --> 00:17:38,910 +عشرة مليون بطلع سبعة و تلاتين مليون + +215 +00:17:41,740 --> 00:17:44,460 +صار عنده في الرصيد تبعه بدل ما هو عنده عشرة شاكل + +216 +00:17:44,460 --> 00:17:48,020 +صار عنده سبعة و تلاتين عشرة مليون دولار صار عنده + +217 +00:17:48,020 --> 00:17:54,780 +سبعة و تلاتين مليون شاكل بيعت + +218 +00:17:54,780 --> 00:17:58,380 +الموظفين راتبهم طيب احنا مازلنا ب option one + +219 +00:17:58,380 --> 00:18:04,010 +مادخلش الrabies chase agreementطبعا مركزين معايا + +220 +00:18:04,010 --> 00:18:09,550 +طيب هلأ صار عنده فلوس البنك العربي يعني لإن + +221 +00:18:09,550 --> 00:18:12,850 +الموظفين قبلات شو بيساوي بيروح بيشتري من ال .. من + +222 +00:18:12,850 --> 00:18:15,850 +المحلات و كذا و بيدفعوا فلوس فالمحلات بيرجعوا + +223 +00:18:15,850 --> 00:18:20,370 +الفلوس لمن؟ للبنك فصار عنده الفلوس قيمتهم مشاكل + +224 +00:18:20,370 --> 00:18:25,050 +فراح بده يشري دولار عشان يرجع رصيده لإيش؟ للدولار + +225 +00:18:25,050 --> 00:18:27,870 +بده يشري دولار راح على السوق okay جالهم مقدداش + +226 +00:18:27,870 --> 00:18:30,990 +الدولار حكوله في السوق احنا الدولار تبعناه تلاتة + +227 +00:18:30,990 --> 00:18:37,100 +فاصلة خمسة سبعيندولار ع الشاكل فإيش راح يسوي؟ راح + +228 +00:18:37,100 --> 00:18:44,360 +يجيب .. كام محتاج شاكل يدفع؟ هيدفع سبعة و تلاتين و + +229 +00:18:44,360 --> 00:18:50,740 +خمسمية ألف شاكل كام خسر البنك العربي؟ نص مليون + +230 +00:18:50,740 --> 00:18:54,980 +شاكل خسر بنات هذه شغلات حقية بتصير في البنوك بس + +231 +00:18:54,980 --> 00:18:58,260 +طبعا البنك عنده ال option two ماعندهش option one + +232 +00:18:59,310 --> 00:19:04,110 +Okay في ال option one the bank is taking risk اتخذ + +233 +00:19:04,110 --> 00:19:08,190 +مخاطر و ممكن السعر ينزل و يكسب ال bank بس احنا + +234 +00:19:08,190 --> 00:19:12,070 +خلينا ناخد the worst case ناخد ال worst case يعني + +235 +00:19:12,070 --> 00:19:17,530 +أسوأ إشي ممكن يصير مع ال bank طيب إذا الخسر في + +236 +00:19:17,530 --> 00:19:24,070 +الحالة هذه 500 ألف لأنه أخد شوفوا أخد 37 مليون و + +237 +00:19:24,070 --> 00:19:28,790 +لما بده يشتريبدو يدفع 37.5 مليون فصار عنده ناقص + +238 +00:19:28,790 --> 00:19:36,070 +500 اللي هو نص مليون شكل طيب في عندهم مدير شاطر + +239 +00:19:36,070 --> 00:19:39,450 +فبيحكي لهم ليش why we go through this خلنا نروح + +240 +00:19:39,450 --> 00:19:45,630 +على option two option two اللي + +241 +00:19:45,630 --> 00:19:49,630 +هو خسر لأن + +242 +00:19:49,630 --> 00:19:55,980 +الدولار ارتفع فصار عنده risk لأن الأرصداءعنده + +243 +00:19:55,980 --> 00:20:00,060 +بالدولار فهو بده يحفظ فيها بالدولار فاحتياجه + +244 +00:20:00,060 --> 00:20:04,340 +للشاكل احتياج يومين طلعت بس فليش انه انا اروح احول + +245 +00:20:04,340 --> 00:20:08,360 +شاكل و اظل رصيدي بالشاكل و اخسر فهو هيستخدم option + +246 +00:20:08,360 --> 00:20:11,600 +2 في الحالة هذه الحالة اخذها لو ما اخذني ماتخذش + +247 +00:20:11,600 --> 00:20:15,160 +منك انت عاد الشراء هذه الحالة لما بدتش .. بالظبط + +248 +00:20:15,160 --> 00:20:18,880 +option option one يعني مافيش اعادة شراء في option + +249 +00:20:18,880 --> 00:20:21,460 +two ايوة + +250 +00:20:22,840 --> 00:20:27,020 +هيكسب اه ماهي فيه ان انا احتمال ربح و احتمال مخاطر + +251 +00:20:27,020 --> 00:20:31,080 +انا أخدت احتمالات الأسوأ طبعا البنوك لما بتبني + +252 +00:20:31,080 --> 00:20:35,180 +قراراتها بتاخد احتمالات الأسوأ عشان هم مايدخلوش في + +253 +00:20:35,180 --> 00:20:39,740 +مخاطر لأنه يحافظوا على أموال المودعين ناخد option + +254 +00:20:39,740 --> 00:20:45,020 +2 نروح + +255 +00:20:45,020 --> 00:20:49,360 +على option 2 و نشوف option + +256 +00:20:49,360 --> 00:20:49,660 +2 + +257 +00:20:55,180 --> 00:21:03,400 +فى option two هيجى طبعا هو اش هيعمل بده يشتري طبعا + +258 +00:21:03,400 --> 00:21:12,880 +شراق شاكل today بده يشتري شاكل today مظبوط and + +259 +00:21:12,880 --> 00:21:18,240 +sell it tomorrow بده + +260 +00:21:18,240 --> 00:21:23,250 +يشتري الشاكل اليومو يبيعوا بكرا أو العكس اللي هو + +261 +00:21:23,250 --> 00:21:27,730 +إذا بديش الشركة اللي بده يبيع إياش بيع دولار today + +262 +00:21:27,730 --> 00:21:36,650 +and sell and buy دولار طبعا هنا بيع هنا sell + +263 +00:21:36,650 --> 00:21:48,350 +dollar today و buy dollar tomorrow، مظبوط؟ ده + +264 +00:21:48,350 --> 00:21:55,550 +بنشوفراح اتصل في البنك فلسطين و حكاله احنا بدنا .. + +265 +00:21:55,550 --> 00:22:03,790 +بدنا شاكل احنا دولار بدنا شاكل بس we need this for + +266 +00:22:03,790 --> 00:22:07,390 +one night بدنا اياها اليوم واحد او two nights + +267 +00:22:08,060 --> 00:22:11,600 +هيشوفوا قصير أجل عشان هيك we call this money + +268 +00:22:11,600 --> 00:22:15,600 +market short term يعني هم الجماعة محتاجينها ليومين + +269 +00:22:15,600 --> 00:22:18,160 +تلاتة فدهش يروح ويحطوا حاله في مخاطر يروح يبيع + +270 +00:22:18,160 --> 00:22:21,700 +الدولار وينتظر الأسعار كيف هتسير و بعدين يكون في + +271 +00:22:21,700 --> 00:22:25,600 +مخاطر بيحكي له okay اتصل في بانك فلسطين كام السعر + +272 +00:22:25,600 --> 00:22:31,680 +بيحكي له أربع فاصلة زي واحد وسبعين لما + +273 +00:22:31,680 --> 00:22:37,730 +بده يبيع الدولار يبيع الدولار بيع الدولارطبعا + +274 +00:22:37,730 --> 00:22:42,790 +بديشريه بكرا شراء الدولار بدل + +275 +00:22:42,790 --> 00:22:46,270 +ما يحكيله اربعة فاصلة مثلا اتنين وسبعين او واحد + +276 +00:22:46,270 --> 00:22:50,410 +وسبعين بيحكيله اسمع نستخدمها repo rate نستخدم repo + +277 +00:22:50,410 --> 00:22:53,970 +rate بعطيك repo rate ايش ال repo rate انه انا + +278 +00:22:53,970 --> 00:22:58,810 +ببيعك الدولار ببيع الدولار الآن و بشري منك بكرا + +279 +00:22:58,810 --> 00:23:04,080 +مثلاأو بالنسبة للبنك العربي بروح ببيع الدولار على + +280 +00:23:04,080 --> 00:23:08,000 +الشاكل بيع دولار أخد شاكل و بكرا بيروح بشري + +281 +00:23:08,000 --> 00:23:11,720 +الدولار من بنك فلسطين بيحكي له أنا بحسب لك repo + +282 +00:23:11,720 --> 00:23:16,760 +rate لا أنا بتتغلب ولا أنت بتتغلب بحسب لك repo + +283 +00:23:16,760 --> 00:23:23,700 +rate مثلا واحد بالألف واحد + +284 +00:23:23,700 --> 00:23:29,020 +بالألف خلاص بحسبله نسبة مقويةواحد بالألف كل الصفقة + +285 +00:23:29,020 --> 00:23:34,080 +عليها واحد بالألف يعني العشرة مليون وضربيهم في + +286 +00:23:34,080 --> 00:23:43,240 +واحد في الألف كم بيطلعوا عشرة مليون نضربهم في واحد + +287 +00:23:43,240 --> 00:23:47,380 +في الألف كم + +288 +00:23:47,380 --> 00:23:51,300 +بيطلع ضربوهم + +289 +00:23:51,300 --> 00:23:52,180 +عندكم بالأقل الحاسبة + +290 +00:23:58,290 --> 00:24:07,930 +واحد بالألف ضرب عشرة مليون ميت .. ميت دولار لأ + +291 +00:24:07,930 --> 00:24:12,690 +عادة بالواحد بالألف ميت دولار يعني إذا ميت دولار + +292 +00:24:12,690 --> 00:24:18,290 +هذه + +293 +00:24:18,290 --> 00:24:25,290 +واحد بالمية لما تضرب في المية okay واحد بالمية في + +294 +00:24:25,290 --> 00:24:29,200 +المية okay تطلع واحد بال .. بالعشر تلاتOkay يعني + +295 +00:24:29,200 --> 00:24:34,940 +خلاني واحد في المية واحد في المية بدنا إياها واحد + +296 +00:24:34,940 --> 00:24:38,100 +في المية في ال .. okay واحد بالألف مظبوط هيك صح؟ + +297 +00:24:38,100 --> 00:24:47,740 +كام بتطلع مية دولار؟ ماتطلعش واحد هاي + +298 +00:24:47,740 --> 00:24:53,140 +ال Excel انتبهوا + +299 +00:24:53,140 --> 00:24:53,280 +يعني + +300 +00:25:00,150 --> 00:25:07,410 +عنا كام؟ عشرة مليون، مظبوط؟ هاي العشرة مليون وعنا + +301 +00:25:07,410 --> 00:25:17,590 +واحد بالألف، هاي واحد بالألف بتساوي ضرب بتلع عشر + +302 +00:25:17,590 --> 00:25:24,550 +تلاف دولار بتلع عشر تلاف دولار okay يعني عشان أسهل + +303 +00:25:24,550 --> 00:25:24,990 +عليكم + +304 +00:25:31,640 --> 00:25:34,740 +Okay بيساوي كام؟ عشرة مليون دولار، فيها بيطلع عشر + +305 +00:25:34,740 --> 00:25:39,660 +تلاف دولار، طب في الحالة الأولى كام خسر؟ خمسمائة + +306 +00:25:39,660 --> 00:25:43,920 +ألف، في الحالة الأولى كام؟ نص مليون، في الحالة + +307 +00:25:43,920 --> 00:25:49,600 +التانية كام؟ عشر تلاف، انه أحسن؟ أحسن عشر تلافيعني + +308 +00:25:49,600 --> 00:25:54,640 +فاسر هنا عشر تلاف شيكل هنا بالشيكل و هنا خمسمية + +309 +00:25:54,640 --> 00:25:59,740 +وبالتالي بتصير عنده أحسن أنه يدخل في السوق ال .. + +310 +00:25:59,740 --> 00:26:03,080 +ال .. ال agreement أحسن طب هلأ كيف راح يصير في + +311 +00:26:03,080 --> 00:26:07,280 +البنك؟ الراح يصير في البنك كالتالي بنك فلسطين .. + +312 +00:26:07,280 --> 00:26:15,880 +بنك العربي انتوا معاه Arab Bank هيرسل دولار ل bank + +313 +00:26:15,880 --> 00:26:23,490 +of Palestineانتفعوا اتجاهات القسم هذا today الbank + +314 +00:26:23,490 --> 00:26:28,790 +of palestine هيعطي البنك العرب ايش؟ هيعطي شكل هو + +315 +00:26:28,790 --> 00:26:37,070 +هيرمز الشكل للبنك العربي هذا today tomorrow ال + +316 +00:26:37,070 --> 00:26:45,030 +arab bank هيروح يعطي ال bank فلسطين ايش هيعطيه + +317 +00:26:45,030 --> 00:26:52,970 +بكرا؟هيعطيه شاكل ايوة هيعطيه شاكل وبنك فلسطين ايش + +318 +00:26:52,970 --> 00:26:56,830 +هيعطيه؟ هيعطيه دولار اتطلعوا على الدولار، الدولار + +319 +00:26:56,830 --> 00:27:02,290 +رجع لمين؟ شوفوا الدولار رجع للبنك العربي okay هذا + +320 +00:27:02,290 --> 00:27:07,110 +بيسموه ال repair chase طيب، ماسألناش سؤال طب بنك + +321 +00:27:07,110 --> 00:27:12,900 +فلسطين يعني شو استفاد من هذا الموضوع؟استفاد من عشر + +322 +00:27:12,900 --> 00:27:18,640 +تلات لكن في نفس اللحظة احتمال يخسر فشو راح يسوي + +323 +00:27:18,640 --> 00:27:25,060 +بنك فلسطين؟ بنك فلسطين هيعمل شغلة اسمها reverse + +324 +00:27:25,060 --> 00:27:31,780 +reverse chase هيعمل reverse مع مين؟ مع بنك آخرمع + +325 +00:27:31,780 --> 00:27:34,980 +بنك تاني، يعني ممكن يعملها مع Deutsch Bank، مع ال + +326 +00:27:34,980 --> 00:27:38,120 +HSBC Bank، ممكن يعملها مع مثلا ال housing bank، + +327 +00:27:38,120 --> 00:27:41,360 +بنك الإسكان و هكذا، كل بنك هيروح يعكسها مع بنك آخر + +328 +00:27:41,360 --> 00:27:44,300 +عشان يعملوا allocation لل risk أو transferring لل + +329 +00:27:44,300 --> 00:27:47,780 +risk اللي أخدناها ب chapter one، فاكرين لما حكينا + +330 +00:27:47,780 --> 00:27:54,800 +transferring لل risk؟ طيب، هلأ ال bank فلسطين إيش + +331 +00:27:54,800 --> 00:27:58,600 +هيسوي؟ يلا مين يحكي لل bank فلسطين إيش هيسوي؟مع + +332 +00:27:58,600 --> 00:28:01,620 +البنك العربي خلاص طب هو بنك فلسطين عشان يحمي ظهره + +333 +00:28:01,620 --> 00:28:06,900 +شو روح يسوي؟ في + +334 +00:28:06,900 --> 00:28:10,180 +.. في اليوم الأول شو حيسوي؟ في .. today هلأ هو صار + +335 +00:28:10,180 --> 00:28:16,900 +عنده .. باليوم الأول صار عنده دولار، مظبوط؟ هيروح + +336 +00:28:16,900 --> 00:28:20,760 +إيش يسوي بنك فلسطين؟ يلا هشوف + +337 +00:28:27,240 --> 00:28:32,920 +خلصنا البنك العرب وبنك الفلسطيني خلصناه هلأ + +338 +00:28:32,920 --> 00:28:37,660 +في اليوم الأول بنك الفلسطيني عنده دولار صح؟ في + +339 +00:28:37,660 --> 00:28:43,360 +اليوم الأول ايوة بيعملها مع بنك تاني مثلا بنك + +340 +00:28:43,360 --> 00:28:51,920 +الإسلامي شو هيعمل معاه؟ بيع دولار هيبيع دولارو + +341 +00:28:51,920 --> 00:28:57,640 +يشتري شاكل، شراء شاكل و تاني يوم ايش هيسوي؟ خليني + +342 +00:28:57,640 --> 00:29:00,420 +اتبيع الدولار، اتبيع الدولار اليوم، هيروح يشتريه + +343 +00:29:00,420 --> 00:29:07,040 +بكرا، شراء دولار، هاي طبعا، اتلاحظوا بيع دولار، + +344 +00:29:07,040 --> 00:29:11,740 +شراء .. شراء دولار بكرا، فصار العملية reverse، + +345 +00:29:11,740 --> 00:29:15,140 +يعني دائما هو بعكس العملية مع بنك .. مع بنك آخر + +346 +00:29:17,330 --> 00:29:21,330 +Okay هذه بيسموها reverse لاحظوا لما احنا حكينا على + +347 +00:29:21,330 --> 00:29:24,970 +ال .. + +348 +00:29:24,970 --> 00:29:32,770 +repos and reverses قرأتوها هان repos and reverses + +349 +00:29:32,770 --> 00:29:38,770 +reverses كل عملية بيعملها bank أخر عكسها okay + +350 +00:29:41,070 --> 00:29:44,130 +يعني نفسنا لو نرجع لفكرة ال mobile لما انا باعت ال + +351 +00:29:44,130 --> 00:29:49,530 +mobile الطرف الآخر هيروح يعكس العملية يبيعه مع طرف + +352 +00:29:49,530 --> 00:29:54,590 +آخر و هكذا لو بعدين تاني يوم هترجع الأمور تتكرر + +353 +00:29:54,590 --> 00:29:58,150 +بالطريقة العكسية هذا بيسموها repurchase agreement + +354 +00:29:58,150 --> 00:30:01,030 +طب علشان بيستخدم ال repurchase agreement عشان ت + +355 +00:30:01,030 --> 00:30:08,330 +allocate risk و تخفض المخاطر okay مرض عليكم + +356 +00:30:08,330 --> 00:30:10,190 +بالحياتكم العملية مثل هالأفر + +357 +00:30:14,460 --> 00:30:18,260 +طبعا هي بالأسواق المالية معروفة يعنى طبعا هلأ نرجع + +358 +00:30:18,260 --> 00:30:21,920 +للسؤال ال ribos مين بحدد ال ribo هل بنك فلسطين هو + +359 +00:30:21,920 --> 00:30:27,360 +بخاطره يحسب ال ribo ال ribo يتم تحديده دوليا يتم + +360 +00:30:27,360 --> 00:30:35,740 +تحديده إيش دوليا كيف يتم تحديده دوليا يتم + +361 +00:30:35,740 --> 00:30:38,640 +تحديده حسب أسعار شغل اسمها library + +362 +00:30:41,820 --> 00:30:48,320 +حسب سعر ال LIBOR دوليا LIBOR + +363 +00:30:48,320 --> 00:30:55,620 +ايش معناه LIBOR LIBOR اجت من البنوك في لندن بتقترض + +364 +00:30:55,620 --> 00:31:03,580 +من بعضها يعني مثلا bank HSBC bank بده فلوس الليلة + +365 +00:31:03,580 --> 00:31:08,120 +هذه لبقرةفأمامه بده يقترض فبالجائش للبنك المركزي + +366 +00:31:08,120 --> 00:31:11,340 +اللي هو ال central bank ال central bank of England + +367 +00:31:11,340 --> 00:31:16,700 +فبروح بتداين من بنك آخر لمدة يوم أو يومين فالبنك + +368 +00:31:16,700 --> 00:31:20,620 +المركزي صار يحدد أسعار أن البنوك تتداين من بعضها + +369 +00:31:20,620 --> 00:31:24,840 +فبيسموه LIBOR London Interbanking Over Rate + +370 +00:31:24,840 --> 00:31:31,900 +فبيسموه London Interbank Over + +371 +00:31:31,900 --> 00:31:33,840 +Rate + +372 +00:31:36,800 --> 00:31:40,280 +اللي هاد نجحت في .. في .. في بريطانيا صار تعمّم + +373 +00:31:40,280 --> 00:31:43,800 +على كل العالم، يعني صار ال bank فلسطين مثلا، ال + +374 +00:31:43,800 --> 00:31:47,260 +bank العربي، ال bank ال .. أي bank في القردن، bank + +375 +00:31:47,260 --> 00:31:50,600 +في مصر، في أوروبا، في الولايات المتحدة الأمريكية، + +376 +00:31:50,600 --> 00:31:54,700 +صاروا يستخدموا ال Iborيستخدموا إيش؟ ال library + +377 +00:31:54,700 --> 00:31:58,340 +عشان هم مايجيش مثلا بنك فلسطيني يحكيله أنا هذا ال + +378 +00:31:58,340 --> 00:32:01,120 +repo تبعي ييجي بنك آخر يحكيله ال repo أعلى + +379 +00:32:01,120 --> 00:32:07,180 +وبالتالي صاروا عساسي وحده الفوائد فصاروا يستخدموا + +380 +00:32:07,180 --> 00:32:11,340 +ال library اللي هو London Interbank Overrate سموه + +381 +00:32:11,340 --> 00:32:14,320 +library معروف روحوا ادخلوا مثلا على Google اكتبوا + +382 +00:32:14,320 --> 00:32:17,800 +library هتشوفوا ال library وهذا ال library updated + +383 +00:32:17,800 --> 00:32:23,430 +every nightupdated every night يعني كل ليلة بيتغير + +384 +00:32:23,430 --> 00:32:29,290 +تمام هذا بيسموه ال library و + +385 +00:32:29,290 --> 00:32:31,510 +بناء على ال library كمان بيحسبوا القروض و بيحسبوا + +386 +00:32:31,510 --> 00:32:36,530 +الودائع و بيحسبوا شغلات كبيرة فيا ريت تكونوا هيك + +387 +00:32:36,530 --> 00:32:39,750 +يعني بال free time تبعكم بس just google library + +388 +00:32:39,750 --> 00:32:43,190 +and read around library how banks و هذا + +389 +00:32:43,190 --> 00:32:46,270 +international standard خدوا بأكم يعني كل البلوك في + +390 +00:32:46,270 --> 00:32:53,080 +العالم كلها بدون استثناء تستخدم ال libraryOkay فى + +391 +00:32:53,080 --> 00:33:06,180 +حد عندى سؤال على ال repos ال + +392 +00:33:06,180 --> 00:33:09,640 +federal funds يعنى لإنه مش احنا مابنستخدمش ال + +393 +00:33:09,640 --> 00:33:12,300 +federal funds هذا مرتبط فى الولايات المتحدة + +394 +00:33:12,300 --> 00:33:18,060 +الأمريكية okay هذا ال federal funds مشبه ال .. + +395 +00:33:18,060 --> 00:33:23,500 +بشبه ال over mice loansيعني البنوك لما بتتدايع من + +396 +00:33:23,500 --> 00:33:28,900 +بعض القانون بسمح للبنوك أن هي تتدايع من بعضها لأن + +397 +00:33:28,900 --> 00:33:32,320 +ال central bank is considered as the last resource + +398 +00:33:33,070 --> 00:33:36,050 +يعني المقرد الأخير أخدته الكلام هذا أو بتعرفوه دي + +399 +00:33:36,050 --> 00:33:39,190 +هو طبعا الملايك الاخير فممنوع البنوك تتصل في البنك + +400 +00:33:39,190 --> 00:33:44,330 +المركزي في طلب السيولة النخدية أو مثلا انا محتاج ك + +401 +00:33:44,330 --> 00:33:50,710 +مثلا نحكي city bank بكرا عنده صفقة بدي أعملها راح + +402 +00:33:50,710 --> 00:33:54,350 +اتطلع القرص ده تبعته ووجد انه city bank بحتاج مثلا + +403 +00:33:54,350 --> 00:33:59,110 +one مليار واحد مليار بده بس بده ياهم ليومين و + +404 +00:33:59,110 --> 00:34:04,340 +بعدين هجيله فلوسفبدل ما يقترض فبروح بحكي مع البنوك + +405 +00:34:04,340 --> 00:34:07,860 +و بستخدموا ال library بستخدموا ال federal funds + +406 +00:34:07,860 --> 00:34:11,520 +فال federal funds هذا يستخدم للإخراج بين البنوك + +407 +00:34:11,520 --> 00:34:20,020 +طبعا كيف بيستخدموا؟ شوفوا كيف بيستخدموا البنك + +408 +00:34:20,020 --> 00:34:27,140 +المركزي كل بنك من البنوك بنك A مثلا و بنك C + +409 +00:34:30,700 --> 00:34:34,100 +بكونوا محتفظين في حسابات لدى إيش؟ لدى ال central + +410 +00:34:34,100 --> 00:34:37,700 +bank ال central bank اللي في الولايات المتحدة إيش + +411 +00:34:37,700 --> 00:34:42,980 +بيسموه؟ بيسموه the federal reserve bank federal + +412 +00:34:42,980 --> 00:34:46,020 +reserve bank اللي هو البنك الفيدرالي .. البنك + +413 +00:34:46,020 --> 00:34:48,640 +الاحتياطي الفيدرالي الأمريكي بالنسبة إحنا في + +414 +00:34:48,640 --> 00:34:51,680 +السلطة الفلسطينية إيش بيسميه؟ بيسميه the monetary + +415 +00:34:51,680 --> 00:34:55,740 +authority .. palestinian monetary authority اللي + +416 +00:34:55,740 --> 00:34:58,440 +هو سلطة النخدة الفلسطينية بالنسبة لمصر إيش بيسميه؟ + +417 +00:34:59,420 --> 00:35:02,260 +اللي هو البنك المركزي المصري بالنسبة للسعودية شو + +418 +00:35:02,260 --> 00:35:08,240 +بنسميه لأ اسمه سلطة النخد السعودي خلاص كل واحد هو + +419 +00:35:08,240 --> 00:35:12,080 +بيعمل مثابة البنك المركزي بالنسبة للأوروبا اللي هو + +420 +00:35:12,080 --> 00:35:15,680 +Europe Central Bank بالنسبة للولايات المتحدة + +421 +00:35:15,680 --> 00:35:18,280 +بيسموها Federal Reserve Bank فال Federal Reserve + +422 +00:35:18,280 --> 00:35:21,940 +Bank Federal Reserve Bank كل بنك من هالبنوك هدول + +423 +00:35:21,940 --> 00:35:28,880 +بيكون محتفظ في أرصدأ عشان تشوف كيف ال fundsالأرصدة + +424 +00:35:28,880 --> 00:35:32,400 +هذه لما البنوك تتدين من بعضها بتدينه من خلال البنك + +425 +00:35:32,400 --> 00:35:37,940 +المركزي كل بنك من البنوك هذا بيحفظ في حسابات البنك + +426 +00:35:37,940 --> 00:35:43,860 +هذا بده فلوس بنك A is in deficit عنده عجز فهياخد + +427 +00:35:43,860 --> 00:35:48,800 +من البنك اللي عنده surplus فاطل ايش راح يصير؟ راح + +428 +00:35:48,800 --> 00:35:58,920 +يصير البنك A عنده عجز minus وبنك C عنده plusالبنك + +429 +00:35:58,920 --> 00:36:05,200 +اللي عنده plus هياخد فائدة والبنك اللي عنده عاجز + +430 +00:36:05,200 --> 00:36:09,580 +هيدفع فائدة فلما سي البلوك تتداي من بعضها جزء من + +431 +00:36:09,580 --> 00:36:22,440 +الفلوس تبع بنك C هتروح ل بنك A يغطيه معاها طبعا + +432 +00:36:22,440 --> 00:36:26,580 +هيتم احتساب هذا المبلغ اللي هيروح بنحسب عليه اللي + +433 +00:36:26,580 --> 00:36:33,670 +يسمونه federalfund rates فائدة، + +434 +00:36:33,670 --> 00:36:37,330 +ليه فائدة؟ هيدفع عليه فائدة، okay؟ هيدفع عليه + +435 +00:36:37,330 --> 00:36:40,560 +فائدةنفس الشيء اللي عندنا في مناطق السلطة + +436 +00:36:40,560 --> 00:36:44,440 +الفلسطينية كل بنك من البنوك بيحتفظ في حساب لدى + +437 +00:36:44,440 --> 00:36:47,780 +سلطة النخدة الفلسطينية وممكن البنوك تدعم بعضها + +438 +00:36:47,780 --> 00:36:51,900 +ويتم احتساب فائدة بتتحددها سلطة النخدة الفلسطينية + +439 +00:36:51,900 --> 00:36:54,960 +طبعا سلطة النخدة الفلسطينية لأنه مافيش عندنا عملة + +440 +00:36:54,960 --> 00:36:58,740 +شكل عملة جنيه فلسطيني فبروحوا بيحسبوا بيحسبوا اللي + +441 +00:36:58,740 --> 00:37:02,220 +هو ممكن ال federal fund rates بيحسبوا اللي هو ال + +442 +00:37:02,220 --> 00:37:07,320 +federal fund rates بالدولار فهذا بيسموه ال federal + +443 +00:37:07,320 --> 00:37:16,170 +fund ratesلأن البنوك تتدايع من بعضها خلصنا؟ + +444 +00:37:16,170 --> 00:37:21,230 +okay خلاص نجف عند هذا الحد عشان المرة الجاية بنحكي + +445 +00:37:21,230 --> 00:37:25,150 +عن ال capital markets المرة الجاية بتحضروا ال + +446 +00:37:25,150 --> 00:37:27,750 +capital markets okay يعطوكوا بالعافية + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/SyEGhcuMf7Y_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/SyEGhcuMf7Y_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..8adfc00a457aad200cc9f04d367eac3184c37036 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/SyEGhcuMf7Y_raw.srt @@ -0,0 +1,2388 @@ +1 +00:00:21,620 --> 00:00:24,980 +اللقاء الفات I left unanswered question regarding + +2 +00:00:24,980 --> 00:00:28,060 +what it means derivatives what it means + +3 +00:00:28,060 --> 00:00:33,100 +derivatives معنى المشتقات و أتوقع إنه إن شاء الله + +4 +00:00:33,100 --> 00:00:40,800 +يكون في إجابة عندكم بالمعنى المشتقات، في حل؟ + +5 +00:00:40,800 --> 00:00:44,440 +مابديش بس أشوف تلت أربعة بنات اللي أمامي هم اللي + +6 +00:00:44,440 --> 00:00:48,160 +بيحكوا، مابدي أشوف كمان اللي وراها أو أنا ممكن + +7 +00:00:48,160 --> 00:00:56,100 +أختار من عندي كمانف okay إيش معنى المشتقات؟ + +8 +00:00:58,540 --> 00:01:03,200 +الو انت اول شي حكيت ان ال real assets هي الأساس + +9 +00:01:03,200 --> 00:01:08,360 +اتبعك بينها ال financial assets و منها بناخد اللي + +10 +00:01:08,360 --> 00:01:11,940 +هو derivatives derivatives اللي هي عبارة عن ال .. + +11 +00:01:11,940 --> 00:01:15,940 +so just just one by one you are right first thing + +12 +00:01:15,940 --> 00:01:19,840 +it means it is derived from the financial assets + +13 +00:01:19,840 --> 00:01:25,100 +just what she said she said that derivatives is + +14 +00:01:25,100 --> 00:01:31,300 +drivenمن الأموال الاجتماعية أو من أسعار الأموال + +15 +00:01:31,300 --> 00:01:37,300 +الاجتماعية فهذه هي الأموال الاجتماعية نحن نحرر + +16 +00:01:37,300 --> 00:01:43,920 +الميزانيات من الأموال الاجتماعية ميزانيات حسنا + +17 +00:01:43,920 --> 00:01:49,380 +دعونا نعود من مجلس المقابلة السابقة نقول أن + +18 +00:01:49,380 --> 00:01:54,680 +الأموال الاجتماعية محررة من ايه؟ + +19 +00:01:54,770 --> 00:01:57,750 +الاستثمار الاجتماعي ليس مجرد واحد من واحد من واحد + +20 +00:01:57,750 --> 00:02:00,390 +من واحد من واحد من واحد من واحد من واحد + +21 +00:02:04,350 --> 00:02:08,650 +نعرف بالفعل أن الحيوانات الحقيقية تنتج حيوانات + +22 +00:02:08,650 --> 00:02:11,950 +اقتصادية ثم حيوانات اقتصادية تتجارب حيوانات + +23 +00:02:11,950 --> 00:02:12,430 +اقتصادية تتجارب حيوانات اقتصادية تتجارب حيوانات + +24 +00:02:12,430 --> 00:02:13,210 +اقتصادية تتجارب حيوانات اقتصادية تتجارب حيوانات + +25 +00:02:13,210 --> 00:02:14,730 +اقتصادية تتجارب حيوانات اقتصادية تتجارب حيوانات + +26 +00:02:14,730 --> 00:02:15,170 +اقتصادية تتجارب حيوانات اقتصادية تتجارب حيوانات + +27 +00:02:15,170 --> 00:02:15,370 +اقتصادية تتجارب حيوانات اقتصادية تتجارب حيوانات + +28 +00:02:15,370 --> 00:02:22,990 +اقتصادية تتجارب حيوانات اقتصادية + +29 +00:02:22,990 --> 00:02:28,090 +تتجthen generate financial asset financial asset + +30 +00:02:28,090 --> 00:02:31,110 +generate the derivatives my second question now + +31 +00:02:31,110 --> 00:02:34,290 +what are the different types of financial asset of + +32 +00:02:34,290 --> 00:02:39,330 +the derivatives what are the main types of + +33 +00:02:39,330 --> 00:02:50,670 +derivatives okay options futures and so on + +34 +00:02:54,860 --> 00:02:58,140 +Okay, so we have three types of financial of + +35 +00:02:58,140 --> 00:03:04,240 +derivatives options futures and as well So in + +36 +00:03:04,240 --> 00:03:09,080 +chapter 11, we will have in-depth look on the + +37 +00:03:09,080 --> 00:03:13,280 +importance of options futures and the as well So + +38 +00:03:13,280 --> 00:03:16,460 +just here you need to have a general idea about + +39 +00:03:16,460 --> 00:03:18,720 +the what it means derivatives and why we use + +40 +00:03:18,720 --> 00:03:25,210 +derivativesللتفكير فهي مرة أخرى تحريكات من أسعار + +41 +00:03:25,210 --> 00:03:31,330 +أخرى من الأمانات مثل الأسعار والمعادلات هذه + +42 +00:03:31,330 --> 00:03:35,730 +هي التحريكات الآن السؤال الثاني هو لماذا نستخدم + +43 +00:03:35,730 --> 00:03:43,910 +التحريكات؟ لتحرير الرسق لذلك كيف؟ كيف نستطيع تحرير + +44 +00:03:43,910 --> 00:03:46,450 +الرسق باستخدام التحريكات؟ هل قمت بتقرير حول هذا؟ + +45 +00:03:49,450 --> 00:03:53,350 +yeah okay that's fine so if you know this transfer + +46 +00:03:53,350 --> 00:03:57,730 +risk this is fine but now how we transfer the risk + +47 +00:03:57,730 --> 00:04:05,890 +okay and for whom we transfer the risk let's take + +48 +00:04:05,890 --> 00:04:12,590 +a example about how we transfer risk if the + +49 +00:04:12,590 --> 00:04:18,190 +company borrow a money you have company Aand + +50 +00:04:18,190 --> 00:04:31,190 +borrow money by loans from bank okay so now who's + +51 +00:04:31,190 --> 00:04:36,330 +taking the risk the bank or the company the bank + +52 +00:04:36,330 --> 00:04:40,330 +okay the + +53 +00:04:40,330 --> 00:04:44,270 +bank now how the bank transfer the money to + +54 +00:04:44,270 --> 00:04:44,930 +someone else + +55 +00:04:49,130 --> 00:04:52,530 +this is the this is the idea because now the bank + +56 +00:04:52,530 --> 00:04:56,010 +is taking risk so how the bank by using + +57 +00:04:56,010 --> 00:04:59,290 +derivatives by using options how the bank can + +58 +00:04:59,290 --> 00:05:01,750 +transfer the money or transfer the risk + +59 +00:05:17,050 --> 00:05:21,710 +بقى in this case how the bank transfer the .. you + +60 +00:05:21,710 --> 00:05:27,770 +are right بقى how the bank transfer the risk money + +61 +00:05:27,770 --> 00:05:35,230 +يعني بمثله طبعا شركة هاي يعني ال bank هذا فيه له + +62 +00:05:35,230 --> 00:05:40,450 +فلوس في عند ال bank فلوس طبع الشركة هاي يعنيياخدها + +63 +00:05:40,450 --> 00:05:45,650 +ايه؟ ال bank هي + +64 +00:05:45,650 --> 00:05:50,590 +risk taker هو بتاخد المخاطر، كيف ممكن تنقل المخاطر + +65 +00:05:50,590 --> 00:05:56,050 +لواحد اخر؟ خليني شوية نفكر، لما ال bank اعطى قرض ل + +66 +00:05:56,050 --> 00:06:00,950 +company ايه؟ طب هلأ مش ال bank لما اعطى القرض؟ فيه + +67 +00:06:00,950 --> 00:06:06,620 +ضماناتطيب خليني أفكه فيها ف .. just .. just think + +68 +00:06:06,620 --> 00:06:13,160 +if the company A fail to repay the .. the bonds or + +69 +00:06:13,160 --> 00:06:17,940 +the .. the loan how the .. the bank ensure to get + +70 +00:06:17,940 --> 00:06:21,860 +the money back؟ يعني لو الشركة ماقدرتش تدفع الفلوس + +71 +00:06:21,860 --> 00:06:25,120 +بتاعتها، كيف الش .. كيف ال bank بدو .. بدو ياخد + +72 +00:06:25,120 --> 00:06:30,340 +فلوسها؟Okay if the bank fail to pay the collateral + +73 +00:06:30,340 --> 00:06:34,480 +collateral يعني الضمانات إذا هذه الشركة فلست وفي + +74 +00:06:34,480 --> 00:06:38,920 +ضمانات ومش قادرين نسير الضمانات خلنا بس احنا بنفكر + +75 +00:06:38,920 --> 00:06:45,260 +تفكير investment from the investment wise this + +76 +00:06:45,260 --> 00:06:52,100 +is one option okay you are right او just to give + +77 +00:06:52,100 --> 00:06:55,360 +you example how we transfer risk we insure the + +78 +00:06:55,360 --> 00:07:01,370 +loansعارفين شو معنى insure؟ insure insure نأمن + +79 +00:07:01,370 --> 00:07:06,650 +نعمل تأمينات so if the bank if the company fail it + +80 +00:07:06,650 --> 00:07:09,510 +means who will pay back the money the insurance + +81 +00:07:09,510 --> 00:07:14,470 +company شركات التأمين وبتسأل احنا شفتوا كيف ممكن + +82 +00:07:14,470 --> 00:07:19,250 +احنا ال financial derivatives ممكن تساعدنا انه + +83 +00:07:19,250 --> 00:07:19,870 +احنا نعمل + +84 +00:07:23,200 --> 00:07:27,620 +نقل للخطر من شركة إلى أخرى فالأخير بعد ال + +85 +00:07:27,620 --> 00:07:32,180 +insurance company who is taking the risk شركة + +86 +00:07:32,180 --> 00:07:36,340 +التأمين شركة التأمين شركة + +87 +00:07:36,340 --> 00:07:37,040 +التأمين شركة التأمين شركة التأمين شركة التأمين + +88 +00:07:37,040 --> 00:07:37,080 +شركة التأمين شركة التأمين شركة التأمين شركة + +89 +00:07:37,080 --> 00:07:37,300 +التأمين شركة التأمين شركة التأمين شركة التأمين + +90 +00:07:37,300 --> 00:07:37,400 +شركة التأمين شركة التأمين شركة التأمين شركة + +91 +00:07:37,400 --> 00:07:37,440 +التأمين شركة التأمين شركة التأمين شركة التأمين + +92 +00:07:37,440 --> 00:07:38,140 +شركة التأمين شركة التأمين شركة التأمين شركة + +93 +00:07:38,140 --> 00:07:42,080 +التأمين شركة التأمين شركة التأمين شركة التأمين + +94 +00:07:42,080 --> 00:07:45,720 +شركة + +95 +00:07:45,720 --> 00:07:50,650 +التأمOkay يعني كيف احنا نعمل كلام هذا هنعمله + +96 +00:07:50,650 --> 00:07:55,590 +تفاصيل في ال chapter eleven يعني خلينا نركز ال + +97 +00:07:55,590 --> 00:08:00,310 +story لما احنا بنعمل transfer ل ال risk ال .. ال + +98 +00:08:00,310 --> 00:08:03,490 +.. ال bank أعطى قرب ل a, a مش قادرين يدفعوا اتخاذ + +99 +00:08:03,490 --> 00:08:09,790 +تبعهم فبروح the bank want to protect his bank بدهم + +100 +00:08:09,790 --> 00:08:13,530 +يحموا دهورهم so how they do this by using + +101 +00:08:13,530 --> 00:08:18,810 +insurance companyOkay هذا بيسموه transfer risk + +102 +00:08:18,810 --> 00:08:22,730 +sometimes they allocate risk what it means + +103 +00:08:22,730 --> 00:08:28,470 +allocate risk يوزع المخاطر so how we derivatives + +104 +00:08:28,470 --> 00:08:32,910 +how can be used to allocate risk نوزع المخاطر + +105 +00:08:32,910 --> 00:08:39,750 +فكروا في الموضوع احنا + +106 +00:08:39,750 --> 00:08:45,510 +عرفنا كيف نقل مخاطر هلأ بكيف نوزع المخاطريعني إيش + +107 +00:08:45,510 --> 00:08:49,170 +نوزع المخاطر؟ يعني إذا أنا بخطر بدل ما أنا أتحمل + +108 +00:08:49,170 --> 00:08:52,050 +الخطر لحالي from the investment-wise let's other + +109 +00:08:52,050 --> 00:08:55,570 +people to consider or to allocate or to share the + +110 +00:08:55,570 --> 00:09:02,750 +risk خليهم يساعدوني في تحمل المخاطر Bank المركزي + +111 +00:09:02,750 --> 00:09:07,850 +okay it is one possible أو طريقة أخرى مجموعة ملوك + +112 +00:09:07,850 --> 00:09:14,020 +ممكن إذا كان مثلا شركة IBM مثلا بدهم قرضبدهم + +113 +00:09:14,020 --> 00:09:17,540 +يعملوا investment في new areas in Africa بدهم + +114 +00:09:17,540 --> 00:09:21,120 +يستثمروا في جنوب أفريقيا and this is a very high + +115 +00:09:21,120 --> 00:09:25,100 +risk environment so what they can do they share + +116 +00:09:25,100 --> 00:09:29,920 +risk with other banks بيشاركوا + +117 +00:09:29,920 --> 00:09:34,180 +المخاطر مع بنوك أخرى rather just to take the risk + +118 +00:09:34,180 --> 00:09:38,300 +you can share the risk with other banks okay so + +119 +00:09:38,300 --> 00:09:40,500 +this is what it means transferring risk allocate + +120 +00:09:40,500 --> 00:09:41,500 +risk + +121 +00:09:45,610 --> 00:09:50,350 +مع بنوك أخرى بدل ما هو ال bank لحاله يتحمل الخطر + +122 +00:09:50,350 --> 00:09:54,530 +فبصير بنوك تانية تتشاركوا بس بالعكس في .. في + +123 +00:09:54,530 --> 00:09:57,990 +الأولى transfer risk you totally transfer risk to + +124 +00:09:57,990 --> 00:10:01,130 +other companies يعني حتى لو في failure هيصير في + +125 +00:10:01,130 --> 00:10:04,370 +أيه هيجي ال insurance company أنه هي تتحمل .. + +126 +00:10:04,370 --> 00:10:05,810 +تتحمل الخطر عادى + +127 +00:10:09,860 --> 00:10:14,720 +هتاخد قرض هي هتتقدم لقرض من بنك نفترض .. لنفترض + +128 +00:10:14,720 --> 00:10:19,140 +أنه هتتقدم من .. من بنك فلسطين okay فهلأ بنك + +129 +00:10:19,140 --> 00:10:22,560 +فلسطين اللي بيشعر أنه القرض كبير فبروح بيعملوا + +130 +00:10:22,560 --> 00:10:26,940 +شغلة اسمها قروض مجمعة قروض إيش؟ مجمعة .. مجمعة هذه + +131 +00:10:26,940 --> 00:10:29,900 +بال .. بال finance and banking بتاخدوها فالقرض + +132 +00:10:29,900 --> 00:10:32,780 +المجمع هذا أكثر من بنك بيشترك في ال .. في القرض + +133 +00:10:32,780 --> 00:10:37,160 +لأنه ال .. ال .. قيمة القرض عالية و مخاطر القرض + +134 +00:10:37,160 --> 00:10:41,630 +كمان عالية فبتساعد they are sharing the riskواضحة؟ + +135 +00:10:41,630 --> 00:10:47,110 +okay فقلنا إيش .. how to use the .. how to use to + +136 +00:10:47,110 --> 00:10:51,230 +transfer the risk and what the other functions of + +137 +00:10:51,230 --> 00:10:56,910 +derivatives when the .. in fact .. when the .. لأ، + +138 +00:10:56,910 --> 00:11:01,530 +كملي هلأ لو كان في مثلا الشركة A شركة أكبر منها + +139 +00:11:01,530 --> 00:11:06,030 +ممكن أنها تساعدها في هذا الاشياء؟أه في حالة انه ال + +140 +00:11:06,030 --> 00:11:09,350 +.. مثلا شركة ال insurance هذه التأمين ممكن إذا + +141 +00:11:09,350 --> 00:11:12,330 +كانت شركة صغيرة تروح تعمل إعادة التأمين أه بيمشي + +142 +00:11:12,330 --> 00:11:17,290 +الحالة الكلام صحيح طيب في ال derivatives في شغلات + +143 +00:11:17,290 --> 00:11:22,050 +تانية أخرى أو عوامل أخرى بسبب إحنا بنستخدم ال + +144 +00:11:22,050 --> 00:11:25,250 +derivatives يعني ليش إحنا بنستخدم ال derivatives + +145 +00:11:25,250 --> 00:11:30,010 +أول شي حكينا لك لأنها بتنقل المخاطر تاني شغلة أنه + +146 +00:11:30,010 --> 00:11:32,630 +بتيم مشاركة المخاطر تالت إشي إشي ممكن نسوي + +147 +00:11:36,050 --> 00:11:41,210 +فكروا هتج هتج + +148 +00:11:41,210 --> 00:11:45,410 +هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج + +149 +00:11:45,410 --> 00:11:47,290 +هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج + +150 +00:11:47,290 --> 00:11:50,170 +هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج + +151 +00:11:50,170 --> 00:11:50,870 +هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج + +152 +00:11:50,870 --> 00:11:51,690 +هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج + +153 +00:11:51,690 --> 00:12:00,350 +هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج هتج + +154 +00:12:00,350 --> 00:12:02,790 +هت + +155 +00:12:03,800 --> 00:12:09,520 +هيدج هيدج يعني دفع مخاطر مش transfer risk هي هيدج + +156 +00:12:09,520 --> 00:12:12,960 +زي + +157 +00:12:12,960 --> 00:12:17,380 +مثال ناخد مثال المرة الفاترة حكينا بدنا نشري سهم + +158 +00:12:17,380 --> 00:12:21,180 +نعطي مثال how to use hedge كيف احنا ممكن نستخدم + +159 +00:12:21,180 --> 00:12:28,160 +الهيدج المرة + +160 +00:12:28,160 --> 00:12:33,000 +الفاترة حكينا اتفقنا انه لو كان سعر السهم عشرين + +161 +00:12:33,000 --> 00:12:45,210 +دولاراتفقنا سعره لان احنا اشتريناه على عشرين او + +162 +00:12:45,210 --> 00:12:52,610 +بدنا نشتريه على عشرين تثبيت fix على عشرين بس + +163 +00:12:52,610 --> 00:12:57,790 +ما معنى فلوس انه نشتري هذا السهم ماعناش فلوسلكن + +164 +00:12:57,790 --> 00:13:01,150 +الفلوس متى هتتوفر؟ هتتوفر بعد ما تلت تلت شهور طب + +165 +00:13:01,150 --> 00:13:03,850 +احنا هنخاف أنه بعد تلت شهور الأسعار إيش تصير فيها + +166 +00:13:03,850 --> 00:13:08,930 +تزيد لأنه إذا زادت الأسعار so we need to pay more + +167 +00:13:08,930 --> 00:13:14,750 +than twenty فإيش لازم نسوي؟ بنروح في شغلة اسمها + +168 +00:13:14,750 --> 00:13:19,050 +option وتحديدا + +169 +00:13:19,050 --> 00:13:24,030 +بال call option call option يعني شراء خيارات طيب + +170 +00:13:24,650 --> 00:13:27,390 +بنروح على ال .. ال .. ال financial market بيحكولنا + +171 +00:13:27,390 --> 00:13:31,670 +احنا بنطلب two dollar على نعمل fixing ده ال price + +172 +00:13:31,670 --> 00:13:35,210 +نثبتلك السعر how they determine two dollar they + +173 +00:13:35,210 --> 00:13:38,810 +have a big equation طبعا مش دوركم ان انتوا تعرفوا + +174 +00:13:38,810 --> 00:13:43,790 +how to calculate the two dollar لأن هاي في معادلة + +175 +00:13:43,790 --> 00:13:46,270 +كبيرة زي من هن والباب المعادلة عشان ايه؟ to + +176 +00:13:46,270 --> 00:13:50,070 +calculate how we estimate two dollar يعني كيف نطلع + +177 +00:13:50,070 --> 00:13:55,450 +ال two dollar هدوة okay soفبيحكينا ال bank او ال + +178 +00:13:55,450 --> 00:13:57,410 +intermediary institutions بيقولنا you have to pay + +179 +00:13:57,410 --> 00:14:03,770 +2$ okay fine لناخد two options ال option ان سعر + +180 +00:14:03,770 --> 00:14:12,790 +السهم بيطلع نفط ل 26$ او سعر السهم صار 16$ 26$ او + +181 +00:14:12,790 --> 00:14:18,290 +16$ هنشوف كيف الهجة ناخد السيناري الأول سعر السهم + +182 +00:14:18,290 --> 00:14:20,210 +ارتفع شو هنسوي + +183 +00:14:27,710 --> 00:14:35,630 +هنسمع .. هنسمع منكم ايش؟ اتنين دولار هتدفعي + +184 +00:14:35,630 --> 00:14:40,650 +يعني عشرين دولار هتدفعي اتنين و عشرين اذا؟ اربع و + +185 +00:14:40,650 --> 00:14:45,070 +عشرين ليش اربع و عشرين؟ خليها بس .. خليها بقى حلوة + +186 +00:14:45,070 --> 00:14:50,450 +انت ثبتت سعرها لعشرين اه و صار عندى اتنين دولار + +187 +00:14:50,450 --> 00:14:55,090 +هدول عربون ال premium صارت اتنين و عشرين مظبوط؟ اه + +188 +00:14:55,090 --> 00:15:01,060 +طيب بعدين؟أنا دفعت ال .. دفعت العشرين و هكمل + +189 +00:15:01,060 --> 00:15:04,320 +للعشرين دفع .. بدك تدفعيهم بالأقل مثلا اه طب و + +190 +00:15:04,320 --> 00:15:07,220 +اتنين و اتنين و عشرين مظبط طب و ايش علاقة الستة و + +191 +00:15:07,220 --> 00:15:10,280 +عشرين هذه الزيادة مالناش ده ربع اه السوق ايش + +192 +00:15:10,280 --> 00:15:13,100 +هيساوي معاكي السوق ايش هيساوي معاكي يقولك تفضلي + +193 +00:15:13,100 --> 00:15:19,440 +هاي أربعة دولار ربحك من هذه ال .. ال .. الصفقة طب + +194 +00:15:19,440 --> 00:15:24,760 +نفترض انه احنا مادخلناش في سوق الخيارات نفترض + +195 +00:15:24,760 --> 00:15:28,490 +مادخلناش في سوق الخياراتتركنا الأمر و لما بعد تلات + +196 +00:15:28,490 --> 00:15:33,090 +شهور ايش راح يصير؟ راح ندفع 26 و بالتالي كام تقول + +197 +00:15:33,090 --> 00:15:39,230 +خسرنا كفرصة مديلة؟ خسرنا 4 دولار شفتوا؟ اذا انا + +198 +00:15:39,230 --> 00:15:43,270 +حولت الخسارة تلاتي الى ربح هتش طب تشوف كيف .. هلأ + +199 +00:15:43,270 --> 00:15:49,710 +لسه يكتب المعنى الهتش؟ خلينا ناخد انه احنا لو + +200 +00:15:49,710 --> 00:15:53,090 +مادخلناش ال option كام هتدفعي لو مادخلتيش ال + +201 +00:15:53,090 --> 00:15:53,510 +option؟ + +202 +00:15:57,200 --> 00:16:02,440 +حد يدفعي 26 طيب لو دخلت ال option كام حد يدفعي 22 + +203 +00:16:02,440 --> 00:16:07,640 +كام الفرق what is the difference أربعة أربعة أربعة + +204 +00:16:07,640 --> 00:16:08,960 +أربعة أربعة أربعة أربعة أربعة أربعة أربعة أربعة + +205 +00:16:08,960 --> 00:16:09,160 +أربعة أربعة أربعة أربعة أربعة أربعة أربعة أربعة + +206 +00:16:09,160 --> 00:16:09,280 +أربعة أربعة أربعة أربعة أربعة أربعة أربعة أربعة + +207 +00:16:09,280 --> 00:16:09,340 +أربعة أربعة أربعة أربعة أربعة أربعة أربعة أربعة + +208 +00:16:09,340 --> 00:16:11,840 +أربعة أربعة أربعة أربعة أربعة أربعة أربعة أربعة + +209 +00:16:11,840 --> 00:16:13,720 +أربعة أربعة أربعة أربعة أربعة أربعة أربعة أربعة + +210 +00:16:13,720 --> 00:16:16,500 +أربعة أربعة أربعة أربعة أربعة أربعة أربعة أربعة + +211 +00:16:16,500 --> 00:16:20,520 +أربعة أربعة أربعة + +212 +00:16:20,520 --> 00:16:25,720 +أهخدهم لأنه انت ثبتت .. ثبتت .. و سعر السوق 26 + +213 +00:16:25,720 --> 00:16:30,240 +بحكيك فهيجي البنك يحكيلك أمامك two options أمام + +214 +00:16:30,240 --> 00:16:35,100 +الخيارات يا إما تاخد السهم هذا اللي ثمنه 26 و + +215 +00:16:35,100 --> 00:16:37,700 +حضرتك تاخد السهم و تروح تبيعي في السوق هتاخده 26 + +216 +00:16:37,700 --> 00:16:41,980 +دولار أو بقولك أنا بتفعلك الفرخ الاربع دولار عشتين + +217 +00:16:41,980 --> 00:16:46,200 +انت ربحانة فاكليها process in your mind ناخد .. + +218 +00:16:46,200 --> 00:16:46,960 +فضلي بالظبط + +219 +00:16:49,970 --> 00:16:56,530 +لو ماكانش خيارات، هتدفعي ستة و عشرين، المعنى كدا + +220 +00:16:56,530 --> 00:17:03,510 +إذا .. ايوة، لو دخلت ستة و عشرين، انت هتخسر هذا + +221 +00:17:03,510 --> 00:17:09,070 +الفرصة البديلة، خسارة، لأ، هيكون خسارة إذا انت + +222 +00:17:09,070 --> 00:17:09,890 +مادخلتيش السوق + +223 +00:17:12,820 --> 00:17:16,580 +يعني المفروض كام تدفع لو دخلت ال option؟ 22 طب لو + +224 +00:17:16,580 --> 00:17:21,620 +مدخلتيش يعني أعطيكم مثال بسيط لو حاكوا .. حاكوا .. + +225 +00:17:21,620 --> 00:17:24,140 +حاكوا في السوق لو حاكوا في السوق اللي بيجي من + +226 +00:17:24,140 --> 00:17:28,760 +الساعة تمانية للعشرة بدفع أربع دولار و اللي بيجي + +227 +00:17:28,760 --> 00:17:33,340 +من العشرة للاطماعش بدفع تمانية دولار الناس متى + +228 +00:17:33,340 --> 00:17:35,720 +هيروحوا على السوق؟ تمانية دولار طيب و لو راحوا من + +229 +00:17:35,720 --> 00:17:39,300 +العشرة للاطماعش شو سيجي؟ هيخسروا أربعة دولار بس + +230 +00:17:39,300 --> 00:17:42,500 +هذه الخسارة .. خسارة إيش بيسميها؟ خسارة فرصة بديلة + +231 +00:17:44,120 --> 00:17:50,500 +مشيت معاكي؟ طيب هلأ ناخد العكس .. العكس .. العكس + +232 +00:17:50,500 --> 00:17:56,880 +أنه .. أنه بدفع 16 بشيري العربان انه .. انه .. انه + +233 +00:17:56,880 --> 00:18:00,580 +بدل ما .. ما .. ما .. بشتر بالعربان و بدفع 16 بدون + +234 +00:18:00,580 --> 00:18:03,160 +ما ادفع السئلة اللي هو الخسارة لأ .. لأ .. لأ .. + +235 +00:18:03,160 --> 00:18:04,660 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +236 +00:18:04,660 --> 00:18:05,020 +.. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. + +237 +00:18:05,020 --> 00:18:05,780 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +238 +00:18:05,780 --> 00:18:06,420 +.. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. + +239 +00:18:06,420 --> 00:18:08,740 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +240 +00:18:11,370 --> 00:18:13,630 +و اذا if you are interested روح تشتريه للسوق + +241 +00:18:13,630 --> 00:18:16,570 +تشتريه هتشتريه في 16 بدل ما انتوا تكونوا شاريها في + +242 +00:18:16,570 --> 00:18:21,670 +26 هنا صار هنا صار فيه هجش ايش الهجش اللي صار + +243 +00:18:21,670 --> 00:18:25,730 +الهجش انا اللي سويته في حالتين الحالة الأولى لما + +244 +00:18:25,730 --> 00:18:30,510 +طلع السهم انا اربحت اربعة دولار و في الحالة + +245 +00:18:30,510 --> 00:18:34,330 +التانية لما نزل السهم انا خسرت فقط two dollar و + +246 +00:18:34,330 --> 00:18:39,120 +كان المفروض لو بدي اشري بدي اشري ب 16وبتاعلي انا + +247 +00:18:39,120 --> 00:18:42,820 +بروح باشري ب 16 احسن ماروح اشري مثلا ب 20 لان لو + +248 +00:18:42,820 --> 00:18:47,320 +اشتريته ب 20 و نزل ل 16 انا خسرت كام في الحالة دى؟ + +249 +00:18:47,320 --> 00:18:53,340 +اربعة دولار فانا قللت الخسارة تبعتي فاللي بيصير لو + +250 +00:18:53,340 --> 00:18:57,940 +ايجي احنا خدنا سفر الخسارة تبعتنا فقط عند التنين و + +251 +00:18:57,940 --> 00:19:03,350 +بعدين الربح مفتوحالخسارة تبعتنا بس 2 دولار في كل + +252 +00:19:03,350 --> 00:19:07,110 +.. حتى لو السوق .. طب اتخيل السوق وصل لصفر .. + +253 +00:19:07,110 --> 00:19:11,950 +مستحيل يصير صفر .. كده إيش خسارتنا .. لو السوق وصل + +254 +00:19:11,950 --> 00:19:17,890 +لصفر .. 2 دولار .. بس 2 .. اللي إحنا حاطناهم .. + +255 +00:19:17,890 --> 00:19:21,170 +لكن لو إحنا السوق حقا وصل Alpha .. عارفين إيش معنى + +256 +00:19:21,170 --> 00:19:25,290 +Alpha؟ مالة نهاية .. إيش ربحنا في الحالة هذه؟ مالة + +257 +00:19:25,290 --> 00:19:29,390 +نهاية ..شوفتوا كيف .. شوفتوا كيف ال investment بي + +258 +00:19:29,390 --> 00:19:33,770 +.. بي .. بيش بيسوي بيعمل infinity for your profits + +259 +00:19:33,770 --> 00:19:39,970 +and limited your risk هذا بيسموه H هذا بيسموه تحوط + +260 +00:19:39,970 --> 00:19:43,670 +تحوط from the opposite direction of the markets + +261 +00:19:43,670 --> 00:19:45,950 +ايش ال opposite direction؟ ال opposite direction + +262 +00:19:45,950 --> 00:19:50,350 +انه ينخفض السوق طب لو أخدنا شغر اسمه bought option + +263 +00:19:50,350 --> 00:19:54,300 +عكسه تماماهذا اسمه call option في شغل اسمها put + +264 +00:19:54,300 --> 00:19:59,320 +option الموضوع هتختلف كل ما بنزل السوق لتحت كل ما + +265 +00:19:59,320 --> 00:20:02,560 +انا ال infinity تبعتي الربح بكون infinity و كل ما + +266 +00:20:02,560 --> 00:20:07,540 +السوق بطلع لفوق بكون الخسارة تبعتي محدودة عكس هذا + +267 +00:20:07,540 --> 00:20:11,380 +تماما عكسه تماما كل ما السوق بنزل لتحت الربح + +268 +00:20:11,380 --> 00:20:15,160 +infinity و كل ما السوق بطلع لفوق بكون الربح just 2 + +269 +00:20:15,160 --> 00:20:20,520 +$أو أفضل خسارة هنا two dollar you lose only two + +270 +00:20:20,520 --> 00:20:25,260 +dollar when the market is go up but your profit is + +271 +00:20:25,260 --> 00:20:29,460 +infinity if the market go down هذا في حالة شغل + +272 +00:20:29,460 --> 00:20:33,220 +اسمها pot option طبعا هذا ال details سناخده في + +273 +00:20:33,220 --> 00:20:39,280 +chapter 11 شفتوا + +274 +00:20:39,280 --> 00:20:44,660 +كيف ال investment بيغير كتير من من سلوك ال risk + +275 +00:20:44,660 --> 00:20:45,400 +والمخاطر + +276 +00:20:48,700 --> 00:20:53,060 +الأن سنتحدث عن السوق الاجتماعي و الاقتصاد لأن + +277 +00:20:53,060 --> 00:21:00,560 +الاستثمار كما ذكرناه قبلها الحواسب الحقيقية تدفع + +278 +00:21:00,560 --> 00:21:07,820 +قيمة للاقتصاد الشركات تعمل و تصنع 2 أشياء، خدمات + +279 +00:21:07,820 --> 00:21:13,920 +جيدة و أموال. الآن بسبب هذا الاتصال السوق + +280 +00:21:13,920 --> 00:21:19,740 +الاجتماعي يعتبر كسيارةas a vehicle to transferring + +281 +00:21:19,740 --> 00:21:24,720 +the real assets into financial assets الأسواق + +282 +00:21:24,720 --> 00:21:27,180 +المالية شو بتسوي؟ هي as a vehicle عارفين مش معناه + +283 +00:21:27,180 --> 00:21:31,320 +vehicle؟ vehicle يعني زي مركبة بتنقل ال real + +284 +00:21:31,320 --> 00:21:35,480 +assets to the financial assets مين المنقل لهذا + +285 +00:21:35,480 --> 00:21:39,240 +الموضوع؟ هو ال financial marketsSo how the + +286 +00:21:39,240 --> 00:21:41,980 +financial markets influence in the economy؟ كيف + +287 +00:21:41,980 --> 00:21:45,500 +بتأثر على الأسواق على الاقتصاد؟ إذا في عندنا + +288 +00:21:45,500 --> 00:21:49,720 +activated financial markets it means the car or + +289 +00:21:49,720 --> 00:21:54,380 +the vehicle will be faster هتكون السيارة أسرع وإذا + +290 +00:21:54,380 --> 00:21:57,800 +كان في عندنا weaknesses financial markets it means + +291 +00:21:57,800 --> 00:22:03,000 +it delay the car or the vehicleهتخليها إيش؟ تبطأ + +292 +00:22:03,000 --> 00:22:06,860 +دي ليه يعني إيش؟ اتبطئها أو تأخرها يعني إذا كان + +293 +00:22:06,860 --> 00:22:11,460 +عند أسواق مالية قوية وكفوة هيكون قدرة الاقتصاد على + +294 +00:22:11,460 --> 00:22:14,520 +تحويل ال real assets into financial assets عالية + +295 +00:22:14,520 --> 00:22:19,060 +كتير very efficient إذا كان عندنا الاقتصاد أو + +296 +00:22:19,060 --> 00:22:21,180 +عندنا الأسواق المالية ضعيفة ال financial markets + +297 +00:22:21,180 --> 00:22:25,120 +ضعيفة هيكسير انه ال transfer of the real assets + +298 +00:22:25,120 --> 00:22:30,520 +into the financial assets is very weakهتكون ضعيفة + +299 +00:22:30,520 --> 00:22:35,440 +وبالتالي إذا كان هذه ال relationship ضعيفة هتكون + +300 +00:22:35,440 --> 00:22:38,240 +there is no adding value to the economy مش هيكون + +301 +00:22:38,240 --> 00:22:43,020 +في زيادة بالاقتصاد، إذا هذا كله متكامل الصناعة + +302 +00:22:43,020 --> 00:22:45,880 +بتكون متطورة ال financial market متطور بكون عندي + +303 +00:22:45,880 --> 00:22:49,220 +ال .. ال .. ال adding value to the economy is high + +304 +00:22:50,200 --> 00:22:54,420 +طيب خلينا نيجي نحكي how these things work كيف ممكن + +305 +00:22:54,420 --> 00:22:56,920 +هذه الأشياء تشتغل the first thing is the + +306 +00:22:56,920 --> 00:22:59,900 +information rule ايش ال information rule what it + +307 +00:22:59,900 --> 00:23:05,640 +means أكيد جريته فيها دور المعرفة دور المعلومات + +308 +00:23:05,640 --> 00:23:12,700 +how the information rule inspire the economy كيف + +309 +00:23:12,700 --> 00:23:13,920 +بيتمشف الاقتصاد + +310 +00:23:18,680 --> 00:23:22,140 +أحنا أعطينالكم ال introduction المقدمة إن ال + +311 +00:23:22,140 --> 00:23:25,220 +financial market is the vehicle that is + +312 +00:23:25,220 --> 00:23:28,200 +transferring the real asset into the financial + +313 +00:23:28,200 --> 00:23:32,320 +assets if we have weak financial markets it will + +314 +00:23:32,320 --> 00:23:35,360 +be delayed if we have strong markets it means it + +315 +00:23:35,360 --> 00:23:39,560 +will be faster طيب واحدة من العوامل اللي بتخلي + +316 +00:23:39,560 --> 00:23:43,640 +تعمل تسريع في الاقتصاد ل information rule how this + +317 +00:23:43,640 --> 00:23:46,080 +come؟ كيك ممكن يصير؟ فضل + +318 +00:23:51,610 --> 00:23:55,570 +بدائل كيف بناء على .. كيهش البدائل؟ يعني مثلا ان + +319 +00:23:55,570 --> 00:23:58,590 +دوستيشن بطل مشروع فالمعلومات هي غير بطل غير معلم + +320 +00:23:58,590 --> 00:24:01,930 +يعني المعلومات هي غير يعني توجهني يعني هو مشروع + +321 +00:24:01,930 --> 00:24:05,630 +أفضل how كيف المعلومات بتتوجهني هذا الموضوع بناء + +322 +00:24:05,630 --> 00:24:08,530 +على إيش؟ راسي المعلومات؟ فضل + +323 +00:24:26,850 --> 00:24:31,670 +السوق من خلال المعلومات هو السوق the market is + +324 +00:24:31,670 --> 00:24:40,840 +smart السوق ذكى if the market is as a manSo he is + +325 +00:24:40,840 --> 00:24:44,620 +smart and he knows which company has a future + +326 +00:24:44,620 --> 00:24:50,020 +prospect and which company has a bad prospect يعني + +327 +00:24:50,020 --> 00:24:53,740 +السوق بعرف أو بيطلع معلومات مين الشركات اللي ناجحة + +328 +00:24:53,740 --> 00:24:55,400 +و مين الشركات اللي فاشلة + +329 +00:24:59,440 --> 00:25:05,180 +yes which company has a good prospect يعني مستقبل + +330 +00:25:05,180 --> 00:25:09,220 +جيد has a good future and which company has a bad + +331 +00:25:09,220 --> 00:25:15,400 +future فالسوق هيش هيسمح هيسمح فقط للشركات with a + +332 +00:25:15,400 --> 00:25:19,680 +strong profile strong profile عارفينش يعني with a + +333 +00:25:19,680 --> 00:25:23,560 +strong record so if all of companies in the + +334 +00:25:23,560 --> 00:25:26,320 +financial market with a strong profile it means + +335 +00:25:26,320 --> 00:25:29,730 +adding value to the economyإذا كان كل الشركات اللي + +336 +00:25:29,730 --> 00:25:35,370 +في السوق عندهم استثمارات قوية هت .. تعطي قدرة + +337 +00:25:35,370 --> 00:25:37,730 +كبيرة للسوق يعني for .. for instance if you have + +338 +00:25:37,730 --> 00:25:39,670 +information now the information rule if you have + +339 +00:25:39,670 --> 00:25:43,450 +information that this company investing in a bad + +340 +00:25:43,450 --> 00:25:47,110 +record invest .. investments so you invest or not + +341 +00:25:47,990 --> 00:25:52,670 +هل تشتري شركات الشركة او لا؟ سؤالي هو لك الآن إذا + +342 +00:25:52,670 --> 00:25:55,910 +كنت كانت شركة مستخدمة تكون لديك معلومات عن شركة + +343 +00:25:55,910 --> 00:26:00,950 +معينة أن هذه الشركة لديها مستقبل سيئ لذا هل تشتري + +344 +00:26:00,950 --> 00:26:05,850 +او لا؟ لست تشتري لذا السيارات الآن تتوقف عن العمل + +345 +00:26:05,850 --> 00:26:13,570 +و الشركة ستغادر السوق فالسوق فقط يحافظ على الشركات + +346 +00:26:13,570 --> 00:26:17,860 +التي تحتوي على مستوى عاليواضحة يعني السوق الملبس + +347 +00:26:17,860 --> 00:26:21,600 +محتفظ في الشركات القوية and others they will leave + +348 +00:26:21,600 --> 00:26:27,200 +the markets yeah kick them out بطلعهم برا so شفتوا + +349 +00:26:27,200 --> 00:26:30,220 +كيف ال market بيعمل على إيش filtering the + +350 +00:26:30,220 --> 00:26:34,430 +companies justOkay guys strong people here and + +351 +00:26:34,430 --> 00:26:37,690 +weak people here just these strong people be in + +352 +00:26:37,690 --> 00:26:40,290 +the market and these people be outside the markets + +353 +00:26:40,290 --> 00:26:43,670 +so what the companies do in this case the weak + +354 +00:26:43,670 --> 00:26:46,830 +markets or the weak companies try to promote + +355 +00:26:46,830 --> 00:26:50,310 +themselves promote يعني يحسنوا حالهم they try to + +356 +00:26:50,310 --> 00:26:52,390 +compete other companies in order to keep + +357 +00:26:52,390 --> 00:26:55,050 +themselves in the market عشان يحافظوا على السوق؟ + +358 +00:26:55,050 --> 00:26:58,910 +بالظبط عشان يظلوا موجودين في السوقOkay because we + +359 +00:26:58,910 --> 00:27:01,930 +are living in a very high competition environment + +360 +00:27:01,930 --> 00:27:06,170 +if we fail to face the competition it means we + +361 +00:27:06,170 --> 00:27:08,490 +will leave the market شوفتوا كيف ال information + +362 +00:27:08,490 --> 00:27:13,270 +rule is important this is why the companies has to + +363 +00:27:13,270 --> 00:27:18,530 +disclose the information to the public this is why + +364 +00:27:18,530 --> 00:27:21,810 +again underline what I'm saying this is why + +365 +00:27:22,860 --> 00:27:27,660 +companies have to disclose the information to the + +366 +00:27:27,660 --> 00:27:32,660 +public يعني عشان هيك الشركات لازم to disclose + +367 +00:27:32,660 --> 00:27:36,190 +عارفين شو معناه disclose؟تنشو بياناتها لل public + +368 +00:27:36,190 --> 00:27:38,790 +even the private information or the public + +369 +00:27:38,790 --> 00:27:42,590 +information because investors are smart and they + +370 +00:27:42,590 --> 00:27:45,670 +analyze this information and then decide whether + +371 +00:27:45,670 --> 00:27:49,190 +this company has a good future prospect or a bad + +372 +00:27:49,190 --> 00:27:54,980 +future prospect شفتوا كيف الدنيا بتمشي؟فعشان هيك + +373 +00:27:54,980 --> 00:27:57,940 +احنا بالشركات تبعتنا ادخلولي على ال website تبعت + +374 +00:27:57,940 --> 00:28:02,280 +ال Palestine Stock Exchange وادخلولي على الشركات + +375 +00:28:02,280 --> 00:28:05,020 +الأمريكية أو بريطانية أو أوروبية شوفوا the amount + +376 +00:28:05,020 --> 00:28:07,660 +of information about these companies and amount of + +377 +00:28:07,660 --> 00:28:11,240 +information about these companies and see even a + +378 +00:28:11,240 --> 00:28:14,800 +very little information very little information is + +379 +00:28:14,800 --> 00:28:18,260 +this close to the public even you know the number + +380 +00:28:18,260 --> 00:28:24,530 +of employeesand how much the executives yield from + +381 +00:28:24,530 --> 00:28:28,730 +the company يعني رواتب الموظفين الكبار منشورة على + +382 +00:28:28,730 --> 00:28:32,810 +القوائم تباعت الشركات طب احنا عندنا لهذا الكلام + +383 +00:28:32,810 --> 00:28:38,270 +مستحيل صح؟ عشان تشوفوا اهم معنى المعلومات كام مهمة + +384 +00:28:38,270 --> 00:28:40,530 +عشان تساعد ال investors to take the decision + +385 +00:28:40,530 --> 00:28:45,450 +consumption timing this is a very important and + +386 +00:28:45,450 --> 00:28:47,630 +this is important to you because you are in the + +387 +00:28:47,630 --> 00:28:52,520 +early stages of your lifeإيش حكيت أنا؟ this is a + +388 +00:28:52,520 --> 00:28:55,100 +very important to you because you are in the early + +389 +00:28:55,100 --> 00:29:00,160 +stages of your life هذا مهم لكوا ليش؟ ليش مهم + +390 +00:29:00,160 --> 00:29:03,740 +لكوا؟ لأن انتوا you are in the early stages of + +391 +00:29:03,740 --> 00:29:09,060 +your life بداية حياتكم okay what it means what it + +392 +00:29:09,060 --> 00:29:12,160 +means for companies what it means for investors + +393 +00:29:12,160 --> 00:29:18,580 +now investors generally speaking investors have to + +394 +00:29:19,450 --> 00:29:22,990 +consumption times and two investment times in + +395 +00:29:22,990 --> 00:29:26,990 +their early ages في فترات البداية الحياة تبعتهم + +396 +00:29:26,990 --> 00:29:33,790 +they earn more they earn more يعني بياخدوا فلوس + +397 +00:29:33,790 --> 00:29:39,210 +كتير يعني خلينا نحكي مثلا وانتوا عمركم من عشرين + +398 +00:29:39,210 --> 00:29:46,730 +لاربعين سنة you earn more ال earning + +399 +00:29:50,810 --> 00:29:58,210 +is greater than the consumption ال + +400 +00:29:58,210 --> 00:30:01,570 +earning يعني الفلوس اللى بتدخل علينا اكتر من + +401 +00:30:01,570 --> 00:30:05,370 +الفلوس اللى بتطلع يعني بناخد فلوس فى فترة الحياة + +402 +00:30:05,370 --> 00:30:07,430 +اللى عمره من العشرين لاربعين او من عشرين لخمسين + +403 +00:30:07,430 --> 00:30:12,350 +and after forties or even after fifties it will be + +404 +00:30:12,350 --> 00:30:17,730 +the opposite نستهلك اكتر لانه بنكبر فبصير عندنا + +405 +00:30:17,730 --> 00:30:18,930 +the consumption + +406 +00:30:22,040 --> 00:30:27,540 +is greater than earnings in this case if you have + +407 +00:30:27,540 --> 00:30:31,760 +like this case so what you can do إذا كان عندنا + +408 +00:30:31,760 --> 00:30:34,480 +الحالة هذه what you can do then يعني طبيعي اليوم + +409 +00:30:34,480 --> 00:30:37,520 +مثلا أبواتكم ما شاء الله عليهم أو أخواتكم أو + +410 +00:30:37,520 --> 00:30:43,900 +أخوانكم في فترة هذه they earn more طيب to invest + +411 +00:30:43,900 --> 00:30:50,310 +إذا حلنا المشكلة هذه إيش؟Why we invest? Because in + +412 +00:30:50,310 --> 00:30:55,390 +a time of earning higher than the consumption, we + +413 +00:30:55,390 --> 00:30:59,510 +have saving. So this saving, we need instruments + +414 +00:30:59,510 --> 00:31:04,270 +to store this money for the future useيعني احنا + +415 +00:31:04,270 --> 00:31:08,230 +هناخد الفلوس هذه اللي هتزيد عن حاجتنا و بالتالي + +416 +00:31:08,230 --> 00:31:12,550 +نروح نعملها investment في أدوات تستطيع تحفظني + +417 +00:31:12,550 --> 00:31:18,030 +القيمة للمستقبل stocks و bonds؟ do we have like + +418 +00:31:18,030 --> 00:31:20,330 +this culture in our life؟ هل عندنا هذه ال culture + +419 +00:31:20,330 --> 00:31:23,760 +في حياتنا ولا لأ؟some people they do and others + +420 +00:31:23,760 --> 00:31:28,600 +they don't يعني ممكن في ناس تروح عنده مثلا راتبه + +421 +00:31:28,600 --> 00:31:33,000 +1500 شكل خلاص بقولك مكفنيش ال 1500 شكل but if he + +422 +00:31:33,000 --> 00:31:36,720 +use it properly he may manage it ممكن يستخدمها + +423 +00:31:36,720 --> 00:31:40,940 +بطريقة صح okay if he use the personal finance + +424 +00:31:40,940 --> 00:31:46,160 +properly he can manage this so the solution is + +425 +00:31:46,160 --> 00:31:52,450 +investments so the investment it meansit means + +426 +00:31:52,450 --> 00:31:58,550 +when the time of consuming high higher than the + +427 +00:31:58,550 --> 00:32:02,590 +earnings so we can bring our money from what we + +428 +00:32:02,590 --> 00:32:07,790 +saved before عشان هيك بيقولوا القرش الأبيض ينفع + +429 +00:32:07,790 --> 00:32:11,950 +اليوم الأسود وطبيعي احنا لما كل إنسان بيكبر فبكون + +430 +00:32:11,950 --> 00:32:15,710 +ال earnings بتنخفضلأنه هيصير عنده ما شاء الله ولاد + +431 +00:32:15,710 --> 00:32:19,910 +و هيصير عنده بيت و هيصير عنده ولاد يروح الجامعة و + +432 +00:32:19,910 --> 00:32:24,990 +ها و يصير يصرف كتير و مافيش .. وبالتالي في .. في + +433 +00:32:24,990 --> 00:32:27,590 +مراحل بداية الحياة بيحتاج .. so the financial + +434 +00:32:27,590 --> 00:32:30,510 +markets facilitate this عشان نعمل linkage with the + +435 +00:32:30,510 --> 00:32:33,050 +financial markets فبتاخد من الناس اللي عندهم + +436 +00:32:33,050 --> 00:32:38,270 +higher earning than consumption بتعملهم investment + +437 +00:32:38,270 --> 00:32:41,590 +and when they grow up so they .. it's give them + +438 +00:32:42,860 --> 00:32:46,580 +فمعنى الكلام الناس اللي .. اللي اليوم الصغيرة in + +439 +00:32:46,580 --> 00:32:49,720 +the early stages they give them money for the + +440 +00:32:49,720 --> 00:32:53,860 +people with the old stages يعني طبيعي الناس الصغار + +441 +00:32:53,860 --> 00:33:02,640 +بيصيروا يعطوا الناس الكبيرة تفضل what does it say? + +442 +00:33:03,020 --> 00:33:07,800 +about what? consumption time or which one? + +443 +00:33:11,080 --> 00:33:15,620 +Financial markets facilitate .. facilitate يعني + +444 +00:33:15,620 --> 00:33:22,380 +بتسهل عملية store your money for the future use + +445 +00:33:22,380 --> 00:33:26,800 +يعني بتقدر انت من خلالها تستثمر في السوق المالي + +446 +00:33:26,800 --> 00:33:32,320 +عشان في المستقبل تاخد فلوسك بزيانةwhat is the + +447 +00:33:32,320 --> 00:33:39,640 +relation between + +448 +00:33:39,640 --> 00:33:42,620 +financial market and economy يعني لو كل واحد فينا + +449 +00:33:42,620 --> 00:33:45,960 +خليني احنا نفكر هذا لو كل واحد فينا نفكر في + +450 +00:33:45,960 --> 00:33:50,620 +الطريقة هذهإيش رح يصير؟ هصير إحنا معناها الفلوس + +451 +00:33:50,620 --> 00:33:55,320 +الزيادة، هنروح نستثمرها في شركات، الشركات هتنتج، + +452 +00:33:55,320 --> 00:33:58,740 +هتزيدلى الاقتصاد، الحكومة هتاخد ضرايب، هتحسنلى + +453 +00:33:58,740 --> 00:34:03,540 +الطرق، هتحسنلى المستشفيات، هتحسنلى كل إشي طب + +454 +00:34:03,540 --> 00:34:07,820 +تصوروا إنه الشخص اللي هان ماعملش saving، حط الفلوس + +455 +00:34:07,820 --> 00:34:11,260 +و راح صرفها على حاله بدون ما يعمل investments إيش + +456 +00:34:11,260 --> 00:34:16,450 +رح يصير؟ المصانع مش هتشتغلتمام؟ الحكومة مش هتاخد + +457 +00:34:16,450 --> 00:34:19,950 +درايب، الطروح هتظلها مكسرة، و المستشفيات هتكون + +458 +00:34:19,950 --> 00:34:24,490 +موضعها سيء، و الدنيا كلها موضعها سيء شفتوا كيف .. + +459 +00:34:24,490 --> 00:34:27,530 +كيف بتعمل ال financial markets؟ عشان هيك أرجع لل + +460 +00:34:27,530 --> 00:34:29,550 +definition ال financial market is a vehicle + +461 +00:34:29,550 --> 00:34:34,470 +vehicle يعني إيش؟ مركبة .. مركبة بتساعدنا ننتقل من + +462 +00:34:34,470 --> 00:34:37,050 +حالة إلى أخر okay؟ + +463 +00:34:40,630 --> 00:34:42,870 +allocate of risk I explain what it means + +464 +00:34:42,870 --> 00:34:45,590 +allocation of risk allocation of risk انه احنا + +465 +00:34:45,590 --> 00:34:48,970 +نوزع المخاطر فال financial market هتوزعنا المخاطر + +466 +00:34:48,970 --> 00:34:52,650 +من من شركة الى اخرى so investors can select + +467 +00:34:52,650 --> 00:34:55,090 +securities consistent with their taste of risk + +468 +00:34:55,090 --> 00:35:01,030 +يعني ممكن يكون انا عندى allocation of risk لو + +469 +00:35:01,030 --> 00:35:05,350 +اجينا احنا هاي اللي احنا موجودين هنا كل واحد موجود + +470 +00:35:05,350 --> 00:35:12,500 +عندنا في القاع هنا عنده riskخاصة فيه في ناس they + +471 +00:35:12,500 --> 00:35:21,080 +prefer risk others they avoid risk others they are + +472 +00:35:21,080 --> 00:35:25,120 +risk neutral يعني في عندنا تلت أنواع من الناس عادة + +473 +00:35:25,120 --> 00:35:33,440 +في عندنا risk takers risk takers okay و عندنا risk + +474 +00:35:33,440 --> 00:35:38,820 +lovers risk takers risk avoiders + +475 +00:35:40,810 --> 00:35:46,690 +and risk neutrals، لدينا + +476 +00:35:46,690 --> 00:35:49,510 +تلاتة أنواع من ال risk risk takers هذي بيسموهم + +477 +00:35:49,510 --> 00:35:53,590 +risk lovers هدول بيحبوا المخاطر وفيه عندنا ال risk + +478 +00:35:53,590 --> 00:35:58,670 +avoiders بتجنبوا المخاطر وفي ناس عندنا ال risk + +479 +00:35:58,670 --> 00:36:04,790 +neutral طيب it's up to you then حسب أنتي وين راحت، + +480 +00:36:04,790 --> 00:36:09,710 +تسأل طبعا مين أحسن، مافيش فيها أحسن وأسوأال risk + +481 +00:36:09,710 --> 00:36:15,110 +يعني ال risk takers risk takers ناس بتاخدوا مخاطر + +482 +00:36:15,110 --> 00:36:22,130 +زي مين زي ال gamblers ال gamblers او + +483 +00:36:22,130 --> 00:36:28,590 +بيسميهم ال speculators ال risk avoiders هدول الناس + +484 +00:36:28,590 --> 00:36:31,790 +يعني مثلا زلم اختيار في السن كبير بدو يستثمر .. + +485 +00:36:31,790 --> 00:36:35,490 +بدو يستثمر فلوسه مش .. مقدرش ياخد مخاطر و إلا إذا + +486 +00:36:35,490 --> 00:36:39,500 +أخد مخاطر بيقولوا أنا في مستشفى الشفاف صح؟أه لأنه + +487 +00:36:39,500 --> 00:36:42,320 +بيصير ال prices of the financial market is highly + +488 +00:36:42,320 --> 00:36:46,340 +fluctuated and his heart attack is fluctuated too + +489 +00:36:46,340 --> 00:36:51,500 +يعني كمان ضربات الخلب هتزيد عنده لأنه بهذا السبب + +490 +00:36:51,500 --> 00:36:56,880 +بيكون risk neutral هو fair هو في النص يعني ممكن + +491 +00:36:56,880 --> 00:37:02,100 +مرات ياخد مخاطر و مرات ماياخدش مخاطرالعامة المالية + +492 +00:37:02,100 --> 00:37:07,400 +تساعدنا في تجارب المخاطر بين المخاطرين المخاطرين + +493 +00:37:07,400 --> 00:37:09,380 +المخاطرين المخاطرين المخاطرين المخاطرين المخاطرين + +494 +00:37:09,380 --> 00:37:09,600 +المخاطرين المخاطرين المخاطرين المخاطرين المخاطرين + +495 +00:37:09,600 --> 00:37:12,700 +المخاطرين المخاطرين المخاطرين المخاطرين المخاطرين + +496 +00:37:12,700 --> 00:37:12,900 +المخاطرين المخاطرين المخاطرين المخاطرين المخاطرين + +497 +00:37:12,900 --> 00:37:14,400 +المخاطرين المخاطرين المخاطرين المخاطرين المخاطرين + +498 +00:37:14,400 --> 00:37:15,860 +المخاطرين المخاطرين المخاطرين المخاطرين المخاطرين + +499 +00:37:15,860 --> 00:37:17,460 +المخاطرين المخاطرين المخاطرين المخاطرين المخاطرين + +500 +00:37:17,460 --> 00:37:28,860 +المخاطرين المخاطرين المخاطرين المخ + +501 +00:37:32,250 --> 00:37:39,310 +the financial markets one of the instructions of + +502 +00:37:39,310 --> 00:37:41,990 +the financial markets and management that + +503 +00:37:41,990 --> 00:37:45,510 +companies has that companies have to do separation + +504 +00:37:45,510 --> 00:37:49,810 +between the ownership and the management لازم يكون + +505 +00:37:49,810 --> 00:37:54,770 +فصل بين الإدارة و بين الملاك ليش؟ مين بيقدر يقول + +506 +00:37:54,770 --> 00:37:59,330 +لي ليش لازم يكون في فصل حسب قرائتكم بين إدارة + +507 +00:37:59,330 --> 00:38:00,630 +الشركة و بين ملاك الشركة + +508 +00:38:07,130 --> 00:38:10,470 +Okay ليش لازم يكون فيه فاصل بين إدارة الشركة و + +509 +00:38:10,470 --> 00:38:17,470 +إقمالها في الشركة؟ + +510 +00:38:17,470 --> 00:38:22,270 +أه ليه بتأكد من ..؟ ممكن أن أحد أشخاص في الشركة + +511 +00:38:22,270 --> 00:38:25,990 +يجيب حاجة لحاجة معينة أو ممكن أن يكون مش دارس + +512 +00:38:25,990 --> 00:38:29,570 +الإدارة كويس بالظبط هي سبب أين؟ بفضلك + +513 +00:38:34,710 --> 00:38:39,950 +تعرفى جامعة شو حكت؟ بتكون هم بيصيروا مصالحهم .. + +514 +00:38:39,950 --> 00:38:44,850 +مصالح الملاك أهم مصالح الشركة فعشان هيك لازم نعمل + +515 +00:38:44,850 --> 00:38:49,850 +separation طيب عملنا separation كيف بيصير ال + +516 +00:38:49,850 --> 00:38:53,670 +separation؟ بيكون عندها هنا ال honors .. اتبعوا لل + +517 +00:38:53,670 --> 00:38:59,590 +story هذه honors .. ال honors they elect .. + +518 +00:38:59,590 --> 00:39:05,280 +بنتخبوا the board of directorsمظبوط؟ أخدتوه هدف + +519 +00:39:05,280 --> 00:39:09,440 +المحاسب وطبعا ال share holders هم ال owners they + +520 +00:39:09,440 --> 00:39:12,180 +elect the board of directors اللي هو أعضاء مجلس + +521 +00:39:12,180 --> 00:39:16,620 +إدارة بيمتخبوهم then the board of directors select + +522 +00:39:16,620 --> 00:39:24,420 +the executives or managers managers بختاروا ال + +523 +00:39:24,420 --> 00:39:27,900 +managers هذا بيسموه separation طب و احنا عملنا + +524 +00:39:27,900 --> 00:39:32,360 +separation إيش اللي راح يصير في الشركة؟واجدوا بال + +525 +00:39:32,360 --> 00:39:35,160 +financial markets لما احنا عملنا separation روحنا + +526 +00:39:35,160 --> 00:39:39,760 +بععدنا الملاك و خلينا بس ال managers هم اللي بتحكم + +527 +00:39:39,760 --> 00:39:45,200 +الشركة and the managers are human beings ايش يعني + +528 +00:39:45,200 --> 00:39:49,880 +و ال managers ايش هم .. are human beings يعني بناء + +529 +00:39:49,880 --> 00:39:54,560 +أدمين so they have their own interest so + +530 +00:39:54,560 --> 00:39:59,240 +accordingly managers prefer their own interest + +531 +00:39:59,240 --> 00:40:00,960 +over the company interest + +532 +00:40:04,080 --> 00:40:08,340 +فهمتوها؟ بالظبط صار يفضلوا مصالح الشخصية على مصالح + +533 +00:40:08,340 --> 00:40:13,140 +الشركة so if they want to take a decision first + +534 +00:40:13,140 --> 00:40:15,400 +thing they evaluate what is the benefit of + +535 +00:40:15,400 --> 00:40:19,310 +themselves before taking the decisionif the + +536 +00:40:19,310 --> 00:40:23,770 +decision help them or increase their benefits so + +537 +00:40:23,770 --> 00:40:27,370 +they will take this otherwise they reject the + +538 +00:40:27,370 --> 00:40:30,190 +decision يعني إذا هم قرروا بدمي عملوا استثمار و + +539 +00:40:30,190 --> 00:40:34,530 +لجوا هذا الاستثمار في مخاطر و ممكن يطلوهم من + +540 +00:40:34,530 --> 00:40:38,530 +الشركة فبروحوش على الاستثمار هذا زي ما احنا عندنا + +541 +00:40:38,530 --> 00:40:42,050 +مثلا ممكن تكون بالبيئة العربية تبعتنا إذا احنا في + +542 +00:40:42,050 --> 00:40:46,530 +عندنا استثمارو المدير بده يروح هذا استثمار و + +543 +00:40:46,530 --> 00:40:51,570 +يستثمر فالمدير ممكن يخاف ان صاحب المشروع يطرده اذا + +544 +00:40:51,570 --> 00:40:55,810 +.. اذا فشل المشروع فبالتالي ايش؟ بنروح باختار + +545 +00:40:55,810 --> 00:41:01,490 +مشاريع سهلة عشان ما يطردوهاش بس هذا غلط لازم احنا + +546 +00:41:01,490 --> 00:41:04,850 +نشجع ال investors .. ال managers انه to take some + +547 +00:41:04,850 --> 00:41:09,350 +time to take risk لازم يتاخدوا مخاطر عشان مشارع .. + +548 +00:41:09,350 --> 00:41:14,020 +في مشاريع تحتاج إلى مخاطرففي الحالة هذه ال + +549 +00:41:14,020 --> 00:41:17,320 +managers إذا كان بمصلحتهم ينفذوا المشروع هينفذوه + +550 +00:41:17,320 --> 00:41:20,720 +إذا مش بمصلحتهم مش هينفذوه هذا إيش بيسميه agency + +551 +00:41:20,720 --> 00:41:26,720 +problem إيش بيسميه agency problem كيف بنتحل ال + +552 +00:41:26,720 --> 00:41:31,660 +agency problem how we ensure that managers they + +553 +00:41:31,660 --> 00:41:35,500 +work for the business objectives not for their + +554 +00:41:35,500 --> 00:41:36,640 +personal objectives + +555 +00:41:43,210 --> 00:41:46,710 +مش أكيد، مش أكيد، هذا إذا احنا بالحالة طبعتنا ممكن + +556 +00:41:46,710 --> 00:41:50,390 +يصير إيه، okay؟ so how we ensure this؟ يعني كيف + +557 +00:41:50,390 --> 00:41:53,150 +ممكن نتأكد؟ خليني أنا .. بناها تفكروا في الموضوع، + +558 +00:41:53,150 --> 00:41:58,470 +كيف احنا .. لحظة بس، كيف ممكن نوجد طريقة .. نوجد + +559 +00:41:58,470 --> 00:42:03,930 +طريقة بحيث أنه نتأكد أن هدول المدرة صحيح ممكن + +560 +00:42:03,930 --> 00:42:07,550 +يحققوا أهدافهم، لكن بالأساس لازم يحققوا أهداف + +561 +00:42:07,550 --> 00:42:13,790 +المشروع أعطوني .. أعطوني فكرة كيف ممكن نسويعطينا + +562 +00:42:13,790 --> 00:42:18,450 +من البنات اللي ورا لنسمع صوتهم البنات اللي ورا انا + +563 +00:42:18,450 --> 00:42:21,610 +طبعا هين حكينا المرة اللي جاي البنات اللي + +564 +00:42:21,610 --> 00:42:25,290 +مابشاركوش يعني على الأقل يعني و أعطوني ideas انا + +565 +00:42:25,290 --> 00:42:29,470 +هأختار أسماء من هان و انا ديهم to ensure ان الكل + +566 +00:42:29,470 --> 00:42:33,190 +بيعمل participation اه تفضلي مثلا اذا كان مثلا + +567 +00:42:33,190 --> 00:42:37,650 +مبلغ شخصية أحافظ أفضل سنة مثلا مبلغ 15 أفضل مثلا + +568 +00:42:37,650 --> 00:42:44,270 +اه احنا نحافظ و ندل المبلغ نحافظ واحد فيه مثلاOkay + +569 +00:42:44,270 --> 00:42:48,690 +إذا هذا إيش نسويها؟ compensation انه أنا ب .. ب .. + +570 +00:42:48,690 --> 00:42:52,230 +بعمل linking .. بعمل linking لل object .. your + +571 +00:42:52,230 --> 00:42:55,390 +personal objective with the company objective عشان + +572 +00:42:55,390 --> 00:42:58,770 +نتأكد من الكلام هذا لازم نعمل شغل اسمه corporate + +573 +00:42:58,770 --> 00:43:04,570 +governance corporate governance لأ corporate + +574 +00:43:04,570 --> 00:43:10,450 +governance حوكمة حوكمة نعمل .. اسمعتوا في كلمة + +575 +00:43:10,450 --> 00:43:16,310 +الحوكمة هذه؟نعمل حوكمة سمعتوا في الحوكمة قبل هيك؟ + +576 +00:43:16,310 --> 00:43:20,750 +بدكم تاخدوها طيب okay so I will leave you in this + +577 +00:43:20,750 --> 00:43:24,410 +point and next meeting we will talk about the + +578 +00:43:24,410 --> 00:43:29,530 +governance الحوكمة + +579 +00:43:34,270 --> 00:43:38,670 +لأ مش حكومة هي how كما انا مش هحكيكوا إيش معناها + +580 +00:43:38,670 --> 00:43:41,530 +لان لإن المرة الجاية هابد أشوفها إنتوا كيف + +581 +00:43:41,530 --> 00:43:46,630 +هتفهموها ال how كما اه + +582 +00:43:46,630 --> 00:43:50,110 +بدنا نشوف I will leave this question for the next + +583 +00:43:50,110 --> 00:43:54,070 +meeting هنسيب هذا السؤال ل next meeting and I will + +584 +00:43:54,070 --> 00:44:00,170 +start from the topيعني هالو ال bottom مكان مسموهم + +585 +00:44:00,170 --> 00:44:03,590 +ال .. the first row is the bottom and the last row + +586 +00:44:03,590 --> 00:44:07,290 +is the .. the top بنربده من الورا نشوف كيف الوضع + +587 +00:44:07,290 --> 00:44:12,030 +تبعهم okay بيجيوا عند هذا الحد و تذكروا أنه ال .. + +588 +00:44:12,030 --> 00:44:18,650 +السؤال تبعنا الحوك بقى هنسأل + +589 +00:44:18,650 --> 00:44:22,850 +السؤال هذا اللقاء الجاي بس ت .. بس ن .. نرجع و ن + +590 +00:44:22,850 --> 00:44:27,490 +.. نذكركوا في اللي حكينا اليومحكينا اليوم عن + +591 +00:44:27,490 --> 00:44:34,050 +derivatives على المشتقات المشتقات بتساعدنا على + +592 +00:44:34,050 --> 00:44:40,090 +التحوط من المخاطر، توزيع المخاطر، نقل المخاطر من + +593 +00:44:40,090 --> 00:44:43,530 +طرف إلى آخر، بعدين حكينا عن علاقة بين الاقتصاد و + +594 +00:44:43,530 --> 00:44:47,090 +بين الأسواق المالية و كيف الأسواق المالية بتساعد + +595 +00:44:47,090 --> 00:44:50,690 +على تنمية الاقتصادية و تسريع العلاقة بين ال real + +596 +00:44:50,690 --> 00:44:54,320 +asset و بين ال financial assetsOkay يعطيكم العافية + +597 +00:44:54,320 --> 00:44:55,240 +و نشوف ال .. + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/Vxx95XDXi4E.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/Vxx95XDXi4E.srt new file mode 100644 index 0000000000000000000000000000000000000000..63ee5c16db677a692f53d76387b1bafc230008e4 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/Vxx95XDXi4E.srt @@ -0,0 +1,2359 @@ +1 +00:00:20,820 --> 00:00:25,600 +لأ احنا اللقاء الفات حكينا في ال risk and return + +2 +00:00:25,600 --> 00:00:31,380 +okay risk and return هو في علاقة opposite أو + +3 +00:00:31,380 --> 00:00:35,200 +positive positive relationship between risk and + +4 +00:00:35,200 --> 00:00:40,660 +return يعني بتكون بهذا الشكل لو احنا حطينا هذا + +5 +00:00:40,660 --> 00:00:48,480 +risk و حطينا هذا return فالعلاقة + +6 +00:00:48,480 --> 00:00:53,890 +بتكون هيك، ما بيزيد ال risk بيزيد ال return هذا + +7 +00:00:53,890 --> 00:00:59,050 +مبدأ بيسموه بالـ .. بال economics there is no free + +8 +00:00:59,050 --> 00:01:03,770 +lunch there is no free lunch there is no free + +9 +00:01:03,770 --> 00:01:07,890 +lunch يعني مافيش إيش ببلاش يعني لما نروح على مطعم + +10 +00:01:07,890 --> 00:01:15,730 +مثلا لازم ندفع لما نخلص الأكل صح ولا لأ نفس الشغل + +11 +00:01:15,730 --> 00:01:19,150 +بالنسبة للمستثمرين لما بيعملوا علاقة بال risk and + +12 +00:01:19,150 --> 00:01:23,030 +return المستثمرين اللي بدهم عائد عالي بدهم يتحملوا + +13 +00:01:23,030 --> 00:01:29,370 +مخاطر عالية and vice versa و العكس صحيح okay يعني + +14 +00:01:29,370 --> 00:01:34,450 +مثلا أنا لما بقى تاجر في الـ .. بيسير استثمار في + +15 +00:01:34,450 --> 00:01:41,310 +استثمارات مخاطرها منخفضة هان فبتكون العائد منخفض + +16 +00:01:41,310 --> 00:01:43,510 +تمام؟ + +17 +00:01:44,440 --> 00:01:49,820 +وإذا أنا استثمرت في مخاطر عالية فهيكون العائد عالي + +18 +00:01:49,820 --> 00:01:56,000 +okay طبعا + +19 +00:01:56,000 --> 00:02:00,860 +لو أنا استثمرت في هذا في الاستثمارات هنا هيكون الـ + +20 +00:02:00,860 --> 00:02:07,060 +risk هذا أعلى من ال risk وبالتالي ال return هيكون + +21 +00:02:07,060 --> 00:02:07,400 +أعلى + +22 +00:02:10,530 --> 00:02:13,970 +طبيعي حد بيستطيع يعطينا مثل بالواقع العملي الموجود + +23 +00:02:13,970 --> 00:02:17,850 +عندنا بحياتنا بغزة مثلا لأن السؤال الأول عندكم بالـ + +24 +00:02:17,850 --> 00:02:21,230 +.. بال assignment مطلوب منك أن نعمل two + +25 +00:02:21,230 --> 00:02:24,670 +reflections on the investment environment in Gaza + +26 +00:02:24,670 --> 00:02:27,550 +فبنعرف أيش ال investment environment في .. في + +27 +00:02:27,550 --> 00:02:31,310 +قطاع غزة in the light of the definitions of the + +28 +00:02:31,310 --> 00:02:36,120 +investment environment طيب، حد بيستطيع تاني مثال كيف + +29 +00:02:36,120 --> 00:02:39,700 +كل ما زادت العائد كل ما زادت مخاطر بيزيد العائد في + +30 +00:02:39,700 --> 00:02:44,580 +الاستثمارات اه تفضلي ال real estate ال real estate + +31 +00:02:44,580 --> 00:02:51,200 +اه طيب + +32 +00:02:51,200 --> 00:02:58,080 +لو أعطينا مثال كمان شو رأيكم مين أكثر مخاطر نحط + +33 +00:02:58,080 --> 00:03:05,130 +وديعة في بنك ولا نحط فلوسنا للاستثمار بالأنفاق بدنا + +34 +00:03:05,130 --> 00:03:10,750 +.. بدنا جواب من البنات اللي ورا، إيش رأيك؟ وديعة في + +35 +00:03:10,750 --> 00:03:15,950 +bank و أقل مخاطر و أقل عائد، تمام والاستثمار + +36 +00:03:15,950 --> 00:03:22,830 +بالأنفاق أظن وضحت الصورة، إذا كل ما أنا بدي أغامر + +37 +00:03:22,830 --> 00:03:27,410 +كل ما بتحمل المغامرة، كل ما زادت المخاطر كل ما + +38 +00:03:27,410 --> 00:03:30,210 +بيزيد العائد، تمام؟ + +39 +00:03:33,550 --> 00:03:39,330 +الـ .. كل الأسواق .. كل الأوراق المالية ممثلة على + +40 +00:03:39,330 --> 00:03:42,650 +خط السوق هذا بيسميه خط السوق اللي هو security + +41 +00:03:42,650 --> 00:03:48,390 +market line بيسميه خط السوق يعني كل الاستثمارات + +42 +00:03:48,390 --> 00:03:52,890 +لازم تكون تعكس المخاطر و تعكس العائد احنا مثلا لها + +43 +00:03:52,890 --> 00:03:58,510 +.. احنا حكينا مثلا الأنفاق بيسموهم tunnels الأنفاق + +44 +00:03:58,510 --> 00:04:01,830 +tunnels investment in tunnels يعني روحنا شوفنا + +45 +00:04:01,830 --> 00:04:04,770 +واحد و أعطينا له فلوسنا و قدّاله استثمرنا في الـ + +46 +00:04:04,770 --> 00:04:08,690 +tunnels طبعا هذه مخاطر ماينفعش ييجي المستثمر + +47 +00:04:08,690 --> 00:04:13,290 +يحكيلي أنه أنا حطيت فلوسي و راحوا علي طبعا أكيد + +48 +00:04:13,290 --> 00:04:16,830 +راح يروح عليك لأن هذا is a high risk investment + +49 +00:04:16,830 --> 00:04:24,010 +المخاطر عالية فيه فالمخاطر هتكون عالية كثير + +50 +00:04:28,140 --> 00:04:31,680 +هلأ إذا كان السوق هو efficient إذا كان السوق إيش + +51 +00:04:31,680 --> 00:04:34,700 +ماله efficient efficient يعني إذا كان السوق كفؤ + +52 +00:04:34,700 --> 00:04:42,680 +إذا كان السوق إيش كفؤ إيش يعني السوق كفؤ السوق كفؤ + +53 +00:04:42,680 --> 00:04:46,420 +بيعني every security reflect security معناه ورقة + +54 +00:04:46,420 --> 00:04:51,340 +مالية every security reflect the risk and return + +55 +00:04:51,340 --> 00:04:53,160 +on the security market line + +56 +00:04:56,150 --> 00:04:59,990 +يعني بتعكس المخاطر تبعتها على خط السوق طب لو احنا + +57 +00:04:59,990 --> 00:05:06,570 +شوفنا الـ .. الـ .. الوضع كتالي لو كان عندي .. + +58 +00:05:06,570 --> 00:05:09,650 +انتبهوا معايا .. لو كان عندي استثمار بالأنفاق هم + +59 +00:05:09,650 --> 00:05:17,010 +.. شوفوا وين؟ إيش معناه الكلام؟ احكي .. احكي .. + +60 +00:05:17,010 --> 00:05:20,970 +حسب الرسم .. بالعربي مش مشكلة، اتطلع فيها منيح + +61 +00:05:20,970 --> 00:05:29,410 +مخاطر قليلة وعالية هذا إيش بنسميه؟ هل هذا صحيح؟ هذا + +62 +00:05:29,410 --> 00:05:36,530 +اسمه miss pricing إيش اسمه؟ miss pricing سوق تسعير + +63 +00:05:36,530 --> 00:05:43,050 +إذا وجدنا حالة زي هيك إذا وجدنا حالة من هالنوع في + +64 +00:05:43,050 --> 00:05:48,870 +السوق معنى الكلام أن السوق المالي غير كفؤ طب احنا + +65 +00:05:48,870 --> 00:05:54,720 +أخذنا هذا بالنسبة لل tunnels شوفوا ال tunnels طيب + +66 +00:05:54,720 --> 00:05:58,040 +لو أخذنا ال CDs إيش معنى ال CDs ال CDs اللي هو + +67 +00:05:58,040 --> 00:06:01,300 +certificate of deposits اللي هو الودائع لو احنا + +68 +00:06:01,300 --> 00:06:06,820 +أخذنا الودائع و حطناها بهذا الشكل شوفوا هان بدي + +69 +00:06:06,820 --> 00:06:10,040 +تحكيلي أنت شو يعني وجود الودائع هان what it means + +70 +00:06:10,040 --> 00:06:16,000 +الـ .. البنت الورقة اه تفضلي مخاطرة + +71 +00:06:16,000 --> 00:06:21,800 +عالية صح؟ منخفض هذا صحيح؟ ممكن يصير في الودائع؟ + +72 +00:06:22,500 --> 00:06:28,580 +المفروض الودائع وين تكون؟ تكون مخاطر منخفضة هذا + +73 +00:06:28,580 --> 00:06:35,360 +إيش بتسميه كمان مرة؟ mispricing سوق .. سوق تسعير + +74 +00:06:35,360 --> 00:06:41,200 +طبعا إذا إحنا شفنا فيه mispricing في السوق معناه + +75 +00:06:41,200 --> 00:06:47,120 +كلام السوق غير كفوء السوق المالي غير كفوء وهذا + +76 +00:06:47,120 --> 00:06:50,060 +اللي بيخلينا نحكي عن ال efficient markets الـ + +77 +00:06:50,060 --> 00:06:53,810 +efficient markets ال efficient market اللي هو السوق + +78 +00:06:53,810 --> 00:06:59,210 +المالي الكفوء السوق المالي الكفوء بيعكس ال risk و + +79 +00:06:59,210 --> 00:07:04,870 +ال return and there is no mispricing وفيش إيش + +80 +00:07:04,870 --> 00:07:09,130 +mispricing فيش سوق تسعير طب الأسواق الأوروبية و + +81 +00:07:09,130 --> 00:07:12,850 +الأمريكية هي هل كفؤة ولا غير كفؤة كفؤة بس بيصير + +82 +00:07:12,850 --> 00:07:17,410 +mispricing في الحالة هي بيسمى الأسواق الأمريكية و + +83 +00:07:17,410 --> 00:07:23,860 +الأمريكية is nearly efficientis إيش nearly + +84 +00:07:23,860 --> 00:07:30,560 +efficient يعني هي تقريبا كفؤة طبعا يعني بيصير فيها + +85 +00:07:30,560 --> 00:07:34,700 +miss pricing لكن ال miss pricing هذا بيكون قليل + +86 +00:07:34,700 --> 00:07:41,440 +جدا and very limited و كثير محدود طيب خليني نرجع و + +87 +00:07:41,440 --> 00:07:45,280 +للـ .. إذا كان عندنا الحالة الأولى كنا احنا في الـ + +88 +00:07:45,280 --> 00:07:52,250 +tunnels و كان عندنا عائد عالي و مخاطر منخفضة، إيش + +89 +00:07:52,250 --> 00:07:55,930 +المستثمرين المفروض يساووا في الحالة هذه؟ أنت لو + +90 +00:07:55,930 --> 00:08:00,770 +شفت هالحالة بتزيد استثمار، إذا buying، نشتري، صح؟ + +91 +00:08:00,770 --> 00:08:05,010 +نشتري في الـ .. نشتغل أو نشتري الاستثمارات، هنا + +92 +00:08:05,010 --> 00:08:08,770 +شراء طب كل ما احنا بنشتري، شو بيصير في الأسعار؟ + +93 +00:08:08,770 --> 00:08:14,970 +ايوا، شوفوا اللي بيصير كل ما .. نحكي على ال price، + +94 +00:08:14,970 --> 00:08:19,420 +هلا ركزوا معايا، price نفترض الأسعار بتاعة الأنفاق + +95 +00:08:19,420 --> 00:08:24,020 +كانت و شوفنا الحالة زي هذه إيش راح يصير؟ راح تصير + +96 +00:08:24,020 --> 00:08:29,660 +الأسعار ترتفع وكل ما بترتفع الأسعار العائد شو + +97 +00:08:29,660 --> 00:08:36,340 +بيصير فيه بنخفض العائد بنخفض كل ما ترتفع الأسعار + +98 +00:08:36,340 --> 00:08:41,400 +.. تذكر دائما كيسة طحين و الكبريت كل ما ارتفع + +99 +00:08:41,400 --> 00:08:45,360 +سعر كيسة طحين كل ما العائد تبعه شو بيصير فيه بنخفض + +100 +00:08:45,360 --> 00:08:48,530 +و الكبريت العائد تبعها أعلى من .. أو chips + +101 +00:08:48,530 --> 00:08:54,490 +الأطفال، تذكرين؟ يعني شوفوا يعني الـ .. الـ .. كيس + +102 +00:08:54,490 --> 00:08:57,910 +الطحين الكبير و ال chips الصغير بس عائلة ال chips + +103 +00:08:57,910 --> 00:09:02,290 +الصغير أعلى من .. لأنه ال price فاللي بيصير أن + +104 +00:09:02,290 --> 00:09:07,170 +احنا هون بالـ .. ال tunnels بيصيروا مستثمرين فيها + +105 +00:09:07,170 --> 00:09:13,090 +miss pricing ال best pricing أن return عالي كثير و + +106 +00:09:13,090 --> 00:09:16,170 +مخاطر مخفضة فالمستثمرين بيصيروا focus on this + +107 +00:09:16,170 --> 00:09:20,790 +بيصيروا ركزوا عليه فال price بتبدأ تطلع تطلع و + +108 +00:09:20,790 --> 00:09:23,950 +العكس بيصير ال return كل ما ال price تطلع الـ + +109 +00:09:23,950 --> 00:09:28,670 +return شو بيصير لما احنا طبعا هي موجودة لما بينزل + +110 +00:09:28,670 --> 00:09:33,040 +هيك هيك هيك و بيصير على ال security market line لما + +111 +00:09:33,040 --> 00:09:38,200 +يصير عند نقطة التوازن يعني هو بيكون هيك صار لما رجع + +112 +00:09:38,200 --> 00:09:41,740 +و صار على نقطة التوازن عندما يصل لمرحلة أن is fair + +113 +00:09:41,740 --> 00:09:49,820 +هو ال risk is equal to return طب لو + +114 +00:09:49,820 --> 00:09:56,060 +أجينا احنا لهنا شو بيصير؟ under priced البنات اللي + +115 +00:09:56,060 --> 00:10:01,810 +هـ .. لو ال CDs احنا شوفوا ال CDs شهادات الإيداع + +116 +00:10:01,810 --> 00:10:07,130 +وودائع إيش شهادات الودائع؟ هي مخاطرها زي ما تشوف + +117 +00:10:07,130 --> 00:10:11,330 +عالية كثير شوفوا ال risk عالي و العائد مخفض طب شو + +118 +00:10:11,330 --> 00:10:16,650 +المستثمرين شو روح يسويها؟ هيخفضوا استثمارهم + +119 +00:10:16,650 --> 00:10:21,570 +هيبيعوا طيب هنرجع لل price خليني أحول لل price + +120 +00:10:21,570 --> 00:10:25,570 +هاي هان ال price نأخذ بالـ .. بالـ .. بالأخضر ال CDs + +121 +00:10:25,570 --> 00:10:31,010 +كانت هان ال price إيش هيصير فيها؟ هتنخفض طب الـ + +122 +00:10:31,010 --> 00:10:34,070 +return هو شو راح يصير فيه؟ كل ما حكينا ال price + +123 +00:10:34,070 --> 00:10:38,990 +بتنخفض العوائد هتطلع، تمام؟ وبالتالي هذا راح يصير + +124 +00:10:38,990 --> 00:10:42,550 +two to two لما يصل أو يطلع هيك لما يصل لمرحلة + +125 +00:10:42,550 --> 00:10:47,850 +عادية، بيصير عن نقطة التعدد، لما يصير لمرحلة there + +126 +00:10:47,850 --> 00:10:52,410 +is no mispricing لما يصير لمرحلة there is no + +127 +00:10:52,410 --> 00:10:56,930 +mispricing بيصير efficient market + +128 +00:10:59,930 --> 00:11:02,610 +لما يكون عندنا مرحلة أنه مافيش عندنا miss + +129 +00:11:02,610 --> 00:11:06,390 +pricing يكون there is no efficient market there + +130 +00:11:06,390 --> 00:11:09,330 +is no arbitrage عارفة يعني arbitrage؟ إيش معنى + +131 +00:11:09,330 --> 00:11:18,330 +arbitrage؟ مافيش مراجحات بتصير arbitrage there is + +132 +00:11:18,330 --> 00:11:22,930 +no arbitrage إذا + +133 +00:11:22,930 --> 00:11:29,090 +ال efficient market هو السوق اللي بيعكس ال risk + +134 +00:11:29,090 --> 00:11:29,670 +and return + +135 +00:11:33,320 --> 00:11:38,200 +في حد عندي سؤال؟ في حد عندي سؤال عن efficient + +136 +00:11:38,200 --> 00:11:50,380 +markets؟ طيب + +137 +00:11:50,380 --> 00:11:55,680 +أمام الحالة هذه اللي بنشوفها إن في عندنا miss + +138 +00:11:55,680 --> 00:11:59,680 +pricing في عندنا نوعين من المستثمرين في عندنا + +139 +00:11:59,680 --> 00:12:04,330 +active management وفيه عندنا passive طبعًا أكيد + +140 +00:12:04,330 --> 00:12:11,490 +قرأته عن ال active و ال passive ال + +141 +00:12:11,490 --> 00:12:15,790 +passive أو نبدأ بال passive ال passive management + +142 +00:12:15,790 --> 00:12:19,170 +they consider that the market is efficient + +143 +00:12:19,170 --> 00:12:25,890 +بيعتبروا ال market إيش ماله is efficient السوق كيفه + +144 +00:12:27,460 --> 00:12:30,940 +وبالتالي إذا السوق كيفه any security .. أي security + +145 +00:12:30,940 --> 00:12:35,700 +is located in this .. security market line is + +146 +00:12:35,700 --> 00:12:39,140 +reflected the risk and return، مظبوط ولا لأ؟ إذا + +147 +00:12:39,140 --> 00:12:42,260 +كان السوق efficient، مع كلام أي security على السوق + +148 +00:12:42,260 --> 00:12:44,540 +.. على خط السوق بتعكس ال risk and return + +149 +00:12:48,000 --> 00:12:51,920 +The managers or the fund managers they do + +150 +00:12:51,920 --> 00:12:55,860 +diversifications بيعملوا تنويع based on the + +151 +00:12:55,860 --> 00:12:59,200 +securities located in the security market line + +152 +00:12:59,200 --> 00:13:06,360 +okay يعني مثلًا أطلعها + +153 +00:13:06,360 --> 00:13:10,820 +البره تاني لو أنا معايا مثلًا ألف دولار معايا ألف + +154 +00:13:10,820 --> 00:13:16,160 +دولار وبدأت أستثمرهم في السوق المالي + +155 +00:13:18,930 --> 00:13:24,830 +فأنا بختار أي ورقة مالية موجودة على خط السوق + +156 +00:13:24,830 --> 00:13:30,170 +نختار A واختارنا B واختارنا C هذا إيش بنسميه لما + +157 +00:13:30,170 --> 00:13:34,650 +اختارنا A B C احنا عملنا تنويع عملنا تنويع بس + +158 +00:13:34,650 --> 00:13:39,310 +احنا فرضنا إن all of the securities located in the + +159 +00:13:39,310 --> 00:13:42,730 +security market line reflecting the risk and + +160 +00:13:42,730 --> 00:13:46,560 +return back to risk and return هذا مسمى إيش passive + +161 +00:13:46,560 --> 00:13:50,920 +management طيب passive management they don't + +162 +00:13:50,920 --> 00:13:55,760 +believe on mispricing ما بيعملوش بال mispricing so + +163 +00:13:55,760 --> 00:14:00,420 +they allocate their resources they allocate their + +164 +00:14:00,420 --> 00:14:04,280 +investments on the security market line and they + +165 +00:14:04,280 --> 00:14:08,620 +will define their portfolios based on the security + +166 +00:14:08,620 --> 00:14:11,660 +market line portfolios يعني محافظهم الاستثمارية + +167 +00:14:11,660 --> 00:14:14,860 +فهم بيروحوا بس بيستثمروا في خط السوق بيشوفوا الأسهم + +168 +00:14:14,860 --> 00:14:17,740 +المدرجة أو المحطوطة على خط السوق أو ال securities و + +169 +00:14:17,740 --> 00:14:20,820 +بيعملوا استثمار عليها هذا بيسميهم شو؟ بيسميهم + +170 +00:14:20,820 --> 00:14:21,280 +passive + +171 +00:14:24,350 --> 00:14:27,530 +passive managements يعني في ال passive managements + +172 +00:14:27,530 --> 00:14:31,990 +في عندنا ورقة A وفي عندنا B وفي عندنا C هدول + +173 +00:14:31,990 --> 00:14:37,390 +passive passive managements هدول passive + +174 +00:14:37,390 --> 00:14:43,540 +managementsthey don't change in their investment + +175 +00:14:43,540 --> 00:14:47,340 +style إيش معناه investment style يعني ما بيغيروش في + +176 +00:14:47,340 --> 00:14:50,580 +سلوكهم الاستثماري خلاص بيضلهم على ال a و b و ال c + +177 +00:14:50,580 --> 00:14:54,840 +لأنه بيعرفوا إن a و b و c هم موزعين على خط السوق + +178 +00:14:54,840 --> 00:14:57,700 +وبالتالي هم أخذوا مخاطر السوق يعني هم بيبقوا مع ال + +179 +00:14:57,700 --> 00:15:04,220 +portfolio ما بتتغير ما بيبذلوش جهد كبير عشان هم بس + +180 +00:15:04,220 --> 00:15:09,570 +بدهم a و b و c هم سلبين عيد عيد كلامك صح يعني هم + +181 +00:15:09,570 --> 00:15:12,590 +عشان يعني ما بياخدوش غير A وB وC ومثلًا ال vegan عشان + +182 +00:15:12,590 --> 00:15:16,390 +.. لأنه موزع .. ال A و ال B و ال C زي ما أنتِ + +183 +00:15:16,390 --> 00:15:20,030 +شايفاها وين ال A و ال B و ال C؟ موزع على خط السوق + +184 +00:15:20,030 --> 00:15:25,980 +وبالتالي تم توزيع مخاطر يعني مثلًا A .. مخاطرها + +185 +00:15:25,980 --> 00:15:31,400 +منخفضة وعائدها منخفض B مخاطرها متوسطة وعائد متوسط + +186 +00:15:31,400 --> 00:15:37,280 +و C مخاطر عالية شوية وبالتالي هم بوزعوا ال portfolio + +187 +00:15:37,280 --> 00:15:41,320 +المحفظة بتاعتهم حسب .. حسب اللي هو المخاطر + +188 +00:15:41,320 --> 00:15:46,260 +المختلفة وبالتالي عندهم محفظة متوسطة المخاطر يعني + +189 +00:15:46,260 --> 00:15:50,060 +لو أخذنا A وB وC على عين الاعتبار شايفين وين اتقاه + +190 +00:15:50,060 --> 00:15:53,040 +وبالتالي متوسطة المخاطر وبيحطوا راسهم وبيناموا + +191 +00:15:53,040 --> 00:15:58,640 +وبيرتاحوا هدوء بيسموهم passive managers طيب، ناخد + +192 +00:15:58,640 --> 00:16:03,800 +عكسهم، كنت بتحكي، تفضلي كيف هم سلبين + +193 +00:16:03,800 --> 00:16:07,060 +أصلًا؟ كيف؟ هم عاملين موازنة بين المخاطر وبين + +194 +00:16:07,060 --> 00:16:09,600 +العائد، يعني هم بيقولوا إن احنا في السوق كله، فهم + +195 +00:16:09,600 --> 00:16:14,850 +كيف سلبين؟ passive مش معناها سلبية لأ passive + +196 +00:16:14,850 --> 00:16:19,410 +management مش .. يعني هم ما بيغيروش .. بس إيش معنى + +197 +00:16:19,410 --> 00:16:24,230 +passive؟ سكون يعني هم ما بيغيروا حسب إيش بتغير + +198 +00:16:24,230 --> 00:16:28,150 +السوق خلاص ما بيغيروش يعني وبالتالي A و B و C بيضلهم + +199 +00:16:28,150 --> 00:16:31,970 +على A و B و C بيعملوا أول مرة حسبتهم بيشوفوا إيش + +200 +00:16:31,970 --> 00:16:36,250 +في عندنا A عائدها ومخاطرها و B عائدها ومخاطرها و + +201 +00:16:36,250 --> 00:16:41,040 +C وبالتالي بيسلّبوا ما بيغيروش ليش؟ لأن في عندهم فرضية + +202 +00:16:41,040 --> 00:16:44,420 +في راسهم إن ال market financial is efficient there + +203 +00:16:44,420 --> 00:16:47,920 +is no mispricing أنتو لاحظوا احنا لما أعطيناكوا + +204 +00:16:47,920 --> 00:16:52,080 +المثال هنا احنا المثال كان عندنا mispricing فبيصير + +205 +00:16:52,080 --> 00:16:57,520 +تغير في ال return و ال risk بناء على ال mispricing + +206 +00:16:57,520 --> 00:17:00,560 +ناخد ال active management اللي هي عكسهم تمامًا + +207 +00:17:00,560 --> 00:17:09,370 +active managers they only invest on mispricing and + +208 +00:17:09,370 --> 00:17:13,030 +they rebalance their portfolios based on the + +209 +00:17:13,030 --> 00:17:18,810 +changes in the efficient markets يعني هم اللي + +210 +00:17:18,810 --> 00:17:23,750 +نفترض بدؤوا في A و B و C لنفترض أقبضوا ب A و B و C + +211 +00:17:23,750 --> 00:17:27,610 +عندهم قناعة أن A لن تبقى عائدها ومخاطرها زي ما هي + +212 +00:17:27,610 --> 00:17:31,290 +و B نفس الشغلة و C نفس الشغلة لن يبدأوا في + +213 +00:17:31,290 --> 00:17:35,770 +mispricing سنكتشف لكم اكتبوا لماذا يحدث الكلام هذا + +214 +00:17:35,770 --> 00:17:40,050 +يعني عندكوا اسألوني لماذا يحدث أن A لا تبقى ال + +215 +00:17:40,050 --> 00:17:47,150 +risk وال return لها ونفسها ناخذ مثال A A يحدث فيها + +216 +00:17:47,150 --> 00:17:53,150 +mispricing what it means mispricing سوق تسعير okay + +217 +00:17:53,150 --> 00:17:56,310 +أكثر + +218 +00:17:56,310 --> 00:17:59,490 +علمية يعني سوق تسعير what it means سوق تسعير what + +219 +00:17:59,490 --> 00:18:04,810 +it means mispricing قرأته + +220 +00:18:04,810 --> 00:18:14,070 +أكيد بال .. كيف أنا بتعرف أن هذا السهم أو هذا ال + +221 +00:18:14,070 --> 00:18:18,840 +.. هو سعر غير حقيقي أعطيكم مثال لو أجينا احنا هنا + +222 +00:18:18,840 --> 00:18:22,100 +في غزة روحنا ساعدنا سعر البندورة بكم؟ هيكون ال 5 + +223 +00:18:22,100 --> 00:18:25,500 +كيلو بمية روحنا على خان يونس كم سعر البندورة؟ هيكون + +224 +00:18:25,500 --> 00:18:29,380 +7 كيلو بمية في miss pricing ولا لأ؟ في miss + +225 +00:18:29,380 --> 00:18:33,380 +pricing فإيش راح يسوّوا تجار غزة؟ هياخدوا التجار + +226 +00:18:33,380 --> 00:18:36,620 +خان يونس هيجيبوا البندورة من خان يونس ويبقوا بها + +227 +00:18:36,620 --> 00:18:41,280 +في غزة قبل ما يصير توازن بالسعر طب إذا احنا عرفنا + +228 +00:18:41,280 --> 00:18:45,320 +miss pricing السعر الحقيقي هو السعر الموجود في خان + +229 +00:18:45,320 --> 00:18:47,580 +يونس مثلًا، تمام؟ + +230 +00:18:55,020 --> 00:19:01,100 +السعر الحقيقي هو بيكون ممثل على خط السوق لكن مرات + +231 +00:19:01,100 --> 00:19:05,440 +إن ممكن السعر الحقيقي ينزل زي ما أنتو شايفين وممكن + +232 +00:19:05,440 --> 00:19:14,230 +يطلع لفوق حسب يعني السعر الحقيقي للسهم ممكن is + +233 +00:19:14,230 --> 00:19:23,570 +moving around the actual price ناخذ مثلًا لسهم + +234 +00:19:23,570 --> 00:19:33,990 +من الأسهم مثلًا ياهو أو IBM طلع لو جينا احنا هذا + +235 +00:19:33,990 --> 00:19:42,700 +ال time T وهذا ال price okay طبعًا نمشي هيك ال time + +236 +00:19:42,700 --> 00:19:47,060 +بزيد ونطلع هيك ال price بيزيد لو جينا احنا أخذنا + +237 +00:19:47,060 --> 00:19:54,120 +هيك تشوفوهم هذه المنحنيات بالأسواق المالية صح؟ طيب + +238 +00:19:54,120 --> 00:20:01,380 +هذا ال price ال price fluctuated طب where is the + +239 +00:20:01,380 --> 00:20:06,580 +actual price؟ وين هو ال actual price؟ وين السعر + +240 +00:20:06,580 --> 00:20:10,140 +الحقيقي لو اجينا احنا حكينا النقطة هذه وين ال + +241 +00:20:10,140 --> 00:20:14,300 +actually price اه + +242 +00:20:14,300 --> 00:20:17,840 +انساعدكم هو صعب شوية عليكم انساعدكم ال actually + +243 +00:20:17,840 --> 00:20:25,820 +price هو السعر هذا هو ال actually price دائمًا + +244 +00:20:25,820 --> 00:20:28,920 +السعر ال .. السعر الموجود في السوق هو سعر + +245 +00:20:28,920 --> 00:20:33,820 +fluctuated around the actual price هو سعر بالذبذب + +246 +00:20:33,820 --> 00:20:37,360 +حولين السعر الحقيقي ناخذ النقطة هذه، طلع النقطة + +247 +00:20:37,360 --> 00:20:41,080 +هذه النقطة هذه إيش صار فيها؟ هذه السعر الحقيقي، + +248 +00:20:41,080 --> 00:20:44,440 +هذه overpriced فالناس بيبقوا يبيعوا يبيعوا لما + +249 +00:20:44,440 --> 00:20:49,180 +ينزل هنابعدين بيصير شغلات أخرى بنزل السعر الناس + +250 +00:20:49,180 --> 00:20:51,740 +بيبدأوا يشتريه وبيبدأ يطلع يطلع وبعدين وهكذا + +251 +00:20:51,740 --> 00:20:55,960 +شوفتوا كيف is fluctuated around the actual price + +252 +00:20:55,960 --> 00:21:00,600 +يعني هذا هو السعر الحقيقي و هذا السعر الموجود في + +253 +00:21:00,600 --> 00:21:06,920 +السوق عشان هيك من المستحيل أنه نجد السعر الحقيقي + +254 +00:21:06,920 --> 00:21:13,120 +يساوي السعر السوقي إذا ال actual price ما بيساويش ال + +255 +00:21:13,120 --> 00:21:15,420 +market price اللي بتشوفوه السعر اللي موجود في + +256 +00:21:15,420 --> 00:21:23,280 +السوق الآن is not equal the actual price طبعا من + +257 +00:21:23,280 --> 00:21:25,580 +ناحية from a financial perspective من وجهة نظر + +258 +00:21:25,580 --> 00:21:30,540 +الماليين هم الماليين ضرر عندهم معادلات تحسب ال + +259 +00:21:30,540 --> 00:21:34,760 +actual price بيقدروا يحسبوا ال actual price و ال + +260 +00:21:34,760 --> 00:21:38,940 +market price معروف فالفرق بين هذا و بين هذا إيش + +261 +00:21:38,940 --> 00:21:46,210 +بتسميه؟لا اشوف الفرق بين هذا ال market price و هذا + +262 +00:21:46,210 --> 00:21:53,930 +ايش بنسميه؟ الفرق هذا هو ال mispricing هو هذا ال + +263 +00:21:53,930 --> 00:21:59,110 +mispricing شوفتوا + +264 +00:21:59,110 --> 00:22:03,970 +كيف؟ يوم مرة نكبر الصورة أكثر + +265 +00:22:10,900 --> 00:22:18,140 +طيب نيجي ناخد ال T ال T time نفترض ناخد مثلا + +266 +00:22:18,140 --> 00:22:22,540 +الأيام .. الأيام الأسبوع و هذا ال price .. الأسعار + +267 +00:22:22,540 --> 00:22:28,260 +.. روحنا أخدنا ال chart .. أخدنا ال chartيعني رسم + +268 +00:22:28,260 --> 00:22:35,180 +بياني لسلوك سعر السوق بيجي هاي سعر مش هيك بتشوفوا + +269 +00:22:35,180 --> 00:22:39,080 +الأسعار بتكون طيب هلأ بدأنا في ال actual price + +270 +00:22:39,080 --> 00:22:42,680 +حكينا اللي بتاعون ال finance بيستطيعوا يحددوا وين + +271 +00:22:42,680 --> 00:22:45,940 +هو ال actual price لنفترض أنه احنا حددنا ال actual + +272 +00:22:45,940 --> 00:22:50,000 +price this is the actual price هذا الخط إيش بنسميه + +273 +00:22:50,000 --> 00:22:56,230 +actual price طب و هذا الخط إيش اسمه؟ الازرق market + +274 +00:22:56,230 --> 00:23:00,870 +price طيب إذا هذا ال actual price and this is + +275 +00:23:00,870 --> 00:23:07,410 +the market price فاهمين لللحظة هذه؟ ناخد احنا .. + +276 +00:23:07,410 --> 00:23:10,670 +ناخد أي نقطة .. أي نقطة على السوق، النقطة هذه و لا + +277 +00:23:10,670 --> 00:23:16,170 +تكون أي نقطة هذه إيش مالها النقطة؟ under priced ولا + +278 +00:23:16,170 --> 00:23:20,010 +over priced؟ under priced ليش؟ لأن أقل من ال + +279 +00:23:20,010 --> 00:23:23,530 +actual price طب إيش رح يصير؟ الناس هتروح تشتري، + +280 +00:23:23,530 --> 00:23:29,590 +صح؟ طيب في حد مع كرة؟ كرة؟ أي كرة؟ لما احنا نمسك + +281 +00:23:29,590 --> 00:23:33,470 +الكرة و نضربها على ال .. على الأرض، إيش بيصير في + +282 +00:23:33,470 --> 00:23:38,060 +الكرة؟ لأن المستثمرين نفسهم ما بيعرفوش بالظبط where + +283 +00:23:38,060 --> 00:23:41,620 +is the actual price إذا هم عارفين بالظبط where is + +284 +00:23:41,620 --> 00:23:45,160 +the actual price كان الكرة اللي بنضربها بتظلها + +285 +00:23:45,160 --> 00:23:48,910 +واقفة عند نقطة محددة وهذا شيء مستحيل because there + +286 +00:23:48,910 --> 00:23:52,350 +is different in their expectations لأن ممكن أنت + +287 +00:23:52,350 --> 00:23:57,010 +تقول أنا ال actual price هان واحد ثاني يقول لأ هان + +288 +00:23:57,010 --> 00:24:00,670 +واحد ثالث تقول لأ وبالتالي في اختلاف على ال actual + +289 +00:24:00,670 --> 00:24:04,510 +price زي الفكرة لما احنا نضرب الكورة على الأرض + +290 +00:24:04,510 --> 00:24:08,090 +وبالتالي الكورة بتبدأ تطلع وتنزل بطريقة معينة لما + +291 +00:24:08,090 --> 00:24:12,410 +يصير فيها سكون وعكس لما تضرب هيك مرة وبالتالي + +292 +00:24:12,410 --> 00:24:18,530 +بتاخد مسار آخر okay فاللي بيصير عندنا كان هان + +293 +00:24:18,530 --> 00:24:23,250 +راحوا الناس بيشتريوا ويشتريوا ويشتريوا عند لحظة + +294 +00:24:23,250 --> 00:24:27,690 +معينة took the actual price صار في equal premium + +295 +00:24:27,690 --> 00:24:31,310 +بس ناس بيحكوا لأ يمكن أعلى من هيك وبضلهم يشتريوا + +296 +00:24:31,310 --> 00:24:36,610 +ووصلوا لهذا الحد عند هذا الحد إيش راح يصير؟ صار + +297 +00:24:36,610 --> 00:24:40,840 +over price فالناس بروحوا بيهاجموا؟ بيروحوا ببيعوا و + +298 +00:24:40,840 --> 00:24:42,920 +هكذا this is the story of the financial market و + +299 +00:24:42,920 --> 00:24:46,260 +هذه قصة السوق المالي طب شو اللي بيخلي الاشي يطلع و + +300 +00:24:46,260 --> 00:24:49,240 +ينزل بهذه الطريقة هذه the difference in investor + +301 +00:24:49,240 --> 00:24:56,000 +expectations difference in investors expectations + +302 +00:24:56,000 --> 00:24:58,260 +اختلافات توقعات المستثمرين بالظبط اختلافات + +303 +00:24:58,260 --> 00:25:02,620 +توقعات المستثمرين لو كنا مع بعض احنا هنا ناخد + +304 +00:25:02,620 --> 00:25:06,200 +مثال بسيط على ال efficient markets لو احنا حكينا + +305 +00:25:06,200 --> 00:25:06,840 +بالتل + +306 +00:25:09,720 --> 00:25:18,440 +7.6 ثمنه الآن بالتل مثلا 4.5 okay ناخد + +307 +00:25:18,440 --> 00:25:23,720 +شوفوا احنا هاي أخدنا chart روحوا أنتم اليوم في + +308 +00:25:23,720 --> 00:25:27,720 +البيت روحوا على bse.com و نزّلوا ال chart تبع بالتل + +309 +00:25:27,720 --> 00:25:33,680 +أخدنا ال chart بهذه الطريقة هذه واحنا هذا سعر 4.70 + +310 +00:25:33,680 --> 00:25:38,980 +سعر بالتل أنا بسألكم سؤال okay سؤال بسيط + +311 +00:25:42,260 --> 00:25:46,160 +ايش رأيكم؟ أنتم شايفين ال trend هذا اسمه trend + +312 +00:25:46,160 --> 00:25:53,320 +التوجه هل السعر هيرتفع ولا سينخفض؟ طيب ممكن تكتبوا + +313 +00:25:53,320 --> 00:25:57,160 +بِورقة هيك لحالكم اكتبوا توقعاتكم كل واحدة بدون ما + +314 +00:25:57,160 --> 00:25:59,480 +تتطلع على جنبها أنتم اعتبروا حالكم مستثمرين + +315 +00:25:59,480 --> 00:26:04,860 +اعتبروا حالكم إيش؟ مستثمرين وهي عندكم ال paletel + +316 +00:26:04,860 --> 00:26:08,120 +هي الآن سعرها 4.7 طيب + +317 +00:26:10,020 --> 00:26:13,320 +بعد الساعة عشرة هيبفتح سوق .. يعني دلوقتي هو فاتح + +318 +00:26:13,320 --> 00:26:18,400 +سوق فلسطين طبعا طلعتوا على السوق شوفتوا السوق شو + +319 +00:26:18,400 --> 00:26:22,180 +.. شو بيصير فيه و بتسألي بدكم أنتم يا تشتريوا يا + +320 +00:26:22,180 --> 00:26:27,160 +تبيعوا اكتبوا .. اكتبوا بورقة هيك السعر اللي أنتم + +321 +00:26:27,160 --> 00:26:34,160 +تتوقعوا لبالته ما .. ما تحكوا اكتبوا السعر بس بس + +322 +00:26:34,160 --> 00:26:38,490 +اكتبوا السعر بورقة صغيرة هيك و أعطيني إياها بدّي ورقة + +323 +00:26:38,490 --> 00:26:45,750 +صغيرة بس هيك ورقة صغيرة يعني بس ورقة صغيرة بس بس + +324 +00:26:45,750 --> 00:26:50,350 +بس + +325 +00:26:50,350 --> 00:26:53,850 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +326 +00:26:53,850 --> 00:26:54,490 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +327 +00:26:54,490 --> 00:26:55,730 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +328 +00:26:55,730 --> 00:26:55,770 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +329 +00:26:55,770 --> 00:27:02,540 +بس بس بس بس بس بس بس بس بس بسألكم كمان ساعة أو يعني + +330 +00:27:02,540 --> 00:27:06,180 +نحكي .. توقع .. إذا بدأت تشتري على كم بتشتري بقى تلعب + +331 +00:27:06,180 --> 00:27:10,780 +.. أربعة .. أربعة فاصلة سبعة لأ ساعة .. لأ ساعة + +332 +00:27:10,780 --> 00:27:17,600 +عشرة و نص يعني ايه للسوق فاتح نص ساعة okay أنت حسب + +333 +00:27:17,600 --> 00:27:20,040 +أنت رؤيتك ما لك دخل في اللي جانبك أنت لما تروح + +334 +00:27:20,040 --> 00:27:25,020 +تشتري بالسوق اه your expectations determine the + +335 +00:27:25,020 --> 00:27:33,530 +price اه مجموعة توقعاتكم هو بحدد السعر لا بسرعة يا + +336 +00:27:33,530 --> 00:27:40,930 +عم كلها ورقة صغيرة ماشي الحال يلا بسرعة اه أعطيني + +337 +00:27:40,930 --> 00:27:44,690 +أعطيني واحدة من البنات بتجمع من هذا المجموعة يعني + +338 +00:27:44,690 --> 00:27:47,530 +أنا كمان دقيقة واحدة من البنات بتجمع واحدة من + +339 +00:27:47,530 --> 00:27:50,630 +البنات بتجمع من هذا المجموعة واحدة من البنات بتجمع + +340 +00:27:50,630 --> 00:27:56,730 +من هذا .. تجمع من البنات يعني معكم دقيقتين عشان + +341 +00:27:56,730 --> 00:28:02,350 +أوريكم كيف في السوق المالي يتم تحديد الأسعار؟ جمع + +342 +00:28:02,350 --> 00:28:06,650 +المدبنة طبعا؟ غالبك؟ + +343 +00:28:06,650 --> 00:28:18,950 +تحولوش + +344 +00:28:18,950 --> 00:28:23,930 +تطلعوا .. ممكن المجموعات تشتغل مع بعض وتقرر بس كويس + +345 +00:28:23,930 --> 00:28:28,670 +أنه تشتغلوا individually إذا اشتغلتوا مجموعات هي + +346 +00:28:28,670 --> 00:28:32,650 +بيسموها بال .. بال investment herding theory نظرية + +347 +00:28:32,650 --> 00:28:36,210 +ال .. ال herding عارفين إيش معنى ال herding نظرية + +348 +00:28:36,210 --> 00:28:40,210 +القطيع يعني الطيور لما بتطير بتطير مع بعض وبالتالي + +349 +00:28:40,210 --> 00:28:44,810 +مجموعات بتحدد الأسعار تمام هيك؟ طيب واحدة من البنات + +350 +00:28:44,810 --> 00:28:50,550 +بس تيجي هان واحدة تعالي يا إيمان نسمع بس افتحي ال + +351 +00:28:50,550 --> 00:28:55,550 +.. الأوراق وأعطيني بس هيك الأسعار + +352 +00:29:00,490 --> 00:29:13,470 +لو جاء 4 يعني حكينا هان 4.7 4.8 4.9 5 4.6 4.5 okay + +353 +00:29:13,470 --> 00:29:24,330 +4.4 نشوف كيف الأسعار هتصير أعطيني ناخد أول واحدة 4 + +354 +00:29:24,330 --> 00:29:28,610 +.7 4.9 5 + +355 +00:29:32,090 --> 00:29:37,370 +خمسة فاصلة تسعة خمسة فاصلة سبعة خمسة فاصلة خمسة + +356 +00:29:37,370 --> 00:29:46,090 +ستة فاصلة خمسة ستة فاصلة سبعة ستة فاصلة سبعة لأ + +357 +00:29:46,090 --> 00:29:50,610 +هان هان نفس الشيء okay okay أربعة فاصلة ثلاثة + +358 +00:29:50,610 --> 00:29:54,770 +أربعة فاصلة ثلاثة انتبه هان هاي إيش صار أربعة + +359 +00:29:54,770 --> 00:30:00,450 +فاصلة ثلاثة ستة فاصلة أربعة ستة فاصلة أربعة أربعة + +360 +00:30:00,450 --> 00:30:04,330 +فاصلة خمسة أربعة + +361 +00:30:04,330 --> 00:30:08,770 +فاصلة تسعة أربعة فاصلة تسعة أربعة فاصلة سبعة أربعة + +362 +00:30:08,770 --> 00:30:16,190 +فاصلة سبعة خمسة فاصلة سبعة خمسة فاصلة سبعة خمسة + +363 +00:30:16,190 --> 00:30:21,490 +خمسة طيب لو كفّ .. لو اكتفينا بهذا العدد إيش رأيكم؟ + +364 +00:30:21,490 --> 00:30:25,410 +شو راح .. راح يصير في السعر؟ هيرتفع هيرتفع ليش؟ + +365 +00:30:25,410 --> 00:30:29,970 +لأن ال expectations تبع الماس الموجودة أعلى بكثير، + +366 +00:30:29,970 --> 00:30:33,230 +بس هذا شو .. شو .. شو اللي صار؟ صار إنه في ناس + +367 +00:30:33,230 --> 00:30:36,610 +عندهم ال .. في over expectations over .. over + +368 +00:30:36,610 --> 00:30:40,050 +optimistic صار عندهم، فإيش راح يصير في السوق؟ + +369 +00:30:40,050 --> 00:30:43,730 +السوق بالظبط أشهد زي ما احنا ضربنا الكرة، احنا + +370 +00:30:43,730 --> 00:30:49,550 +عندنا .. تبعوا علي، عندنا السعر لو احنا حسبنا + +371 +00:30:49,550 --> 00:30:54,990 +المنطقة هذه، كدهش المتوسط تبعها، مثل المتوسط ممكن + +372 +00:30:54,990 --> 00:31:02,450 +يكون 4.9 يعني هذه 4.9 هذا ال ceiling اللي بيسموه ال + +373 +00:31:02,450 --> 00:31:07,110 +threshold مرة ثانية معاكي كلمة threshold ال threshold هي + +374 +00:31:07,110 --> 00:31:12,210 +السقف لما نضرب الكورة لازم يخبط فيه في السقف هذا + +375 +00:31:12,210 --> 00:31:15,790 +هو أعلى سقف ممكن نصل إليه طيب اللي بيصير احنا + +376 +00:31:15,790 --> 00:31:20,370 +threshold هو 4.9 سعر الحقيقي المفروض لكن إيش اللي + +377 +00:31:20,370 --> 00:31:25,170 +بيصير السعر ضرب في السعر الحقيقي و بدأ يرتفع شوي شوي + +378 +00:31:25,170 --> 00:31:28,970 +شوي و هيرجع في المرة الثانية هيبدأ ينزل okay + +379 +00:31:28,970 --> 00:31:33,510 +فالسعر is rounding حوالين الأربعة فاصلة تسعة but + +380 +00:31:33,510 --> 00:31:37,630 +nobody knows ولا واحد مننا بيعرف يعني ولا واحد + +381 +00:31:37,630 --> 00:31:41,110 +يعني ما فيش حد اتفق بالظبط مية بالمية أن السعر + +382 +00:31:41,110 --> 00:31:47,750 +أربعة فاصلة تسعة ما حدش طبعًا فاهم اللي بيحدد السعر في + +383 +00:31:47,750 --> 00:31:51,670 +السوق هم الـ customers or investors expectations طب + +384 +00:31:51,670 --> 00:31:55,970 +السؤال اللي أنا بدي أسألكوا ياه كمان مرة لو أنا + +385 +00:31:55,970 --> 00:31:59,130 +أعطيتكوا معلومات شوفوا هل الـ efficient markets لو + +386 +00:31:59,130 --> 00:32:03,450 +أنا أنتو intentionally حاكيتلكم لإن تعملوا كلام + +387 +00:32:03,450 --> 00:32:11,250 +هذا لإن طب لو أنا عملتلكوا شغلتلكم okay هاي سعر + +388 +00:32:11,250 --> 00:32:18,850 +السوق وهي بيانات الشركة اتوقعوا لي كمان مرة حسب + +389 +00:32:18,850 --> 00:32:23,910 +البيانات فالتوقع هيختلف التوقع هيصير أقرب لل + +390 +00:32:23,910 --> 00:32:30,670 +actual price طيب فهمنا كيف؟ طب إذا كنا أنا أعطيكم + +391 +00:32:30,670 --> 00:32:35,050 +public information يعني أنتو في الحالة الأولى + +392 +00:32:35,050 --> 00:32:39,050 +استخدمتوا معلوماتكم العادية اللي بتقرؤوها بالأخبار + +393 +00:32:39,050 --> 00:32:43,050 +اللي في الـ media و روحتوا قررتوا السعر طب لو أنا + +394 +00:32:43,050 --> 00:32:47,570 +أعطيتكم private information إذا في عندنا نوعين في + +395 +00:32:47,570 --> 00:32:51,330 +عندنا public information و في عندنا private + +396 +00:32:51,330 --> 00:32:54,590 +information السؤال اللي أنا بدأ أسأله الـ private + +397 +00:32:54,590 --> 00:32:57,050 +information is the private information available + +398 +00:32:57,050 --> 00:33:02,150 +for everyone؟ no الـ + +399 +00:33:02,150 --> 00:33:04,910 +private information is limited to the insiders + +400 +00:33:04,910 --> 00:33:10,850 +limited لمن؟ للـ insiders مين هم الـ insiders؟ مش + +401 +00:33:10,850 --> 00:33:15,250 +اللي بيشتغلوا مش أي واحد في الشركة هم الناس they + +402 +00:33:15,250 --> 00:33:19,450 +hold the private information اللي عندهم المعلومات + +403 +00:33:19,450 --> 00:33:23,410 +الداخلية وبالتالي كل ما يكون فيه أن الـ private + +404 +00:33:23,410 --> 00:33:28,690 +information is available okay هنصل لـ ال pricing لـ + +405 +00:33:28,690 --> 00:33:36,470 +الـ actual price للـ actual price طيب خلينا نشوف + +406 +00:33:36,470 --> 00:33:42,090 +الفرق بين إذا كانت المعلومات متوفرة وإذا كانت + +407 +00:33:42,090 --> 00:33:46,710 +المعلومات غير متوفرة بينا ناخد two charts الـ chart + +408 +00:33:46,710 --> 00:33:52,610 +في availability for information والـ chart في no + +409 +00:33:52,610 --> 00:33:54,610 +availability for information زي ما احنا طوينا + +410 +00:33:54,610 --> 00:33:58,090 +ساولا معاكم قلنا لكوا اتفضلوا اعطوني سعر وماعندكم + +411 +00:33:58,090 --> 00:34:01,250 +مش معلومات طب لو احنا عكسنا أعطيناكم معلومات وقلنا + +412 +00:34:01,250 --> 00:34:04,450 +لكم اعملوا predictions للسعر هتشوف الـ two cases + +413 +00:34:04,450 --> 00:34:05,490 +كيف بيختلفوا عن بعض + +414 +00:34:18,730 --> 00:34:27,470 +طبعًا هاي الـ T و هاي الـ price ناخد هذا + +415 +00:34:27,470 --> 00:34:36,410 +سوق هذا يهو شركة يهو و ناخد شركة أخرى موجودة مثلًا + +416 +00:34:36,410 --> 00:34:44,050 +بالسعودية مثلًا شركة إعمار أو شركة في دبي + +417 +00:34:52,550 --> 00:34:57,510 +إيش اللي بيصير شوفوا + +418 +00:34:57,510 --> 00:35:01,970 +الفرق لو اجينا احنا بنعمل الـ actual price هان و + +419 +00:35:01,970 --> 00:35:11,110 +بناخد الـ actual price هان الـ actual price زي + +420 +00:35:11,110 --> 00:35:16,110 +ما أنتو شايفين هذا هو الـ actual price و لو اجينا + +421 +00:35:16,110 --> 00:35:20,170 +أحدنا الـ actual price هان هي شركة Yahoo و شركة + +422 +00:35:20,170 --> 00:35:33,380 +إعمار إيش الفرق بيناتهم؟ فضل بالظبط + +423 +00:35:33,380 --> 00:35:36,700 +there is no .. يعني there is a little mispricing + +424 +00:35:36,700 --> 00:35:40,980 +بيكون الـ mispricing بسيط طلع على شركة أما عارف ش + +425 +00:35:40,980 --> 00:35:44,620 +اللي بيصير الـ + +426 +00:35:44,620 --> 00:35:50,500 +mispricing اللي هي الفرق بين هذه و هذه عالية الـ + +427 +00:35:50,500 --> 00:35:53,660 +variance لو احنا نحسب بلغة الإحصاء variance + +428 +00:35:53,660 --> 00:35:59,360 +التباين عالي لكن لو أجينا احنا هان التباين الـ + +429 +00:35:59,360 --> 00:36:05,940 +variance أو sigma قليلة كتير و هذا الفرق بين أسواق + +430 +00:36:05,940 --> 00:36:10,080 +شركة فيها كفاءة في التسعير و شركة كفائتها أقل في + +431 +00:36:10,080 --> 00:36:14,380 +التسعير الـ efficient markets okay so the efficient + +432 +00:36:14,380 --> 00:36:22,520 +markets في السوق المالي بيكون السعر الـ market + +433 +00:36:22,520 --> 00:36:29,380 +price is closer to the actual price but in the + +434 +00:36:29,380 --> 00:36:35,000 +semi strong efficient markets or weak markets بيكون + +435 +00:36:35,000 --> 00:36:41,860 +the actual price is far away from the market price + +436 +00:36:41,860 --> 00:36:49,080 +تمام واضح الكلام هذا نعيد كلام مرة لو احنا عندنا + +437 +00:36:49,080 --> 00:36:52,800 +سوقين السوق فيه كفاءة مالية و السوق ما فيش فيه + +438 +00:36:52,800 --> 00:36:57,380 +كفاءة مالية فالسوق اللي فيه كفاءة مالية بيكون سعر + +439 +00:36:57,380 --> 00:37:03,180 +السوق قريب من الـ actual price السعر الحقيقي بيكون + +440 +00:37:03,180 --> 00:37:10,020 +فيه كفاءة وإذا السوق المالي الغير كفوء بيكون السعر + +441 +00:37:10,020 --> 00:37:13,980 +السوق بعيد كتير عن .. إذا احنا لما بنختبر كفاءة + +442 +00:37:13,980 --> 00:37:18,020 +سوق سهل ما تصير لما بنختبر أن هذا .. نحكي أن هذا + +443 +00:37:18,020 --> 00:37:26,260 +السوق المالي كفوء ولا غير كفوء هاي + +444 +00:37:26,260 --> 00:37:29,960 +بدأت جاوبك إذا كانش .. إذا كان الـ variance قليل + +445 +00:37:30,630 --> 00:37:34,170 +عادي روح جيب البيانات وحطيها في الـ Excel و + +446 +00:37:34,170 --> 00:37:36,590 +calculate variance و calculate sigma هتطلع عندك + +447 +00:37:36,590 --> 00:37:43,590 +كفاءة السوق okay عندك خبرة في الـ Excel؟ بتيجي + +448 +00:37:43,590 --> 00:37:48,770 +بتاخدي حساب و تحليل مالي بتصير عندك خبرة okay + +449 +00:37:48,770 --> 00:37:58,230 +okay + +450 +00:37:58,230 --> 00:38:07,250 +في حد عندك سؤال؟ أه اتفضلي الزمن + +451 +00:38:07,250 --> 00:38:14,050 +مو أنت بتحددي observations حسب الزمن هذا .. هذا الـ + +452 +00:38:14,050 --> 00:38:21,310 +charts زمني لفترات زمنية و بترقمي فيها طيب خليني + +453 +00:38:21,310 --> 00:38:27,770 +أكمل واضحة الفكرة هذه أه؟ في حد عنده سؤال is + +454 +00:38:27,770 --> 00:38:29,030 +unclear أه؟ + +455 +00:38:32,550 --> 00:38:40,790 +هلا ممتازين رضى الله إن شاء الله إذا احنا حكينا عن + +456 +00:38:40,790 --> 00:38:44,170 +الـ active management حكينا عن الـ mis pricing و + +457 +00:38:44,170 --> 00:38:47,630 +timing the markets اللي أنت سألتي timing the + +458 +00:38:47,630 --> 00:38:51,310 +markets يعني احنا بندخل في السوق لما نشعر أن + +459 +00:38:51,310 --> 00:38:56,410 +there is mis pricing okay طيب و الـ passive + +460 +00:38:56,410 --> 00:39:01,030 +management حكيناها okay دي players مين الـ players + +461 +00:39:01,030 --> 00:39:04,950 +اللي في السوق المالي؟ مين هم اللاعبين في الأسواق + +462 +00:39:04,950 --> 00:39:10,230 +المالية؟ + +463 +00:39:10,230 --> 00:39:16,210 +اللاعبين في الأسواق المالية business firms شركات + +464 +00:39:16,210 --> 00:39:22,410 +بيكونوا net borrowers هم مقترضين بدهم يقترضوا وعنا + +465 +00:39:22,410 --> 00:39:26,890 +الـ households net savers هم المداخرين وال + +466 +00:39:26,890 --> 00:39:30,570 +governments الحكومة الحكومة هي بتكون net borrowers + +467 +00:39:30,570 --> 00:39:33,570 +أما net savers يعني ممكن تكون على الجانب هذا وممكن + +468 +00:39:33,570 --> 00:39:42,730 +تكون جانب هذا باختصار انتبهوا + +469 +00:39:42,730 --> 00:39:49,810 +معايا إيه علاقة بالاقتصاد نربط + +470 +00:39:49,810 --> 00:39:53,250 +الموضوع كله في بعض في عندي أنا الـ real estate real + +471 +00:39:53,250 --> 00:39:55,890 +asset مظبوط + +472 +00:39:57,410 --> 00:40:01,850 +إيش حكينا الـ real asset؟ produce goods, services + +473 +00:40:01,850 --> 00:40:08,230 +and income إيه بتعطيني income؟ الـ income بروح + +474 +00:40:08,230 --> 00:40:14,010 +بنعمل consumption استهلاك واللي بيزيد بنعمل إيه؟ + +475 +00:40:14,010 --> 00:40:21,710 +saving بنعمل إيه؟ saving فـ الـ saving بروح عند اللي + +476 +00:40:21,710 --> 00:40:28,410 +هو الـ savers الناس اللي معها الفلوس طيب الـ savers + +477 +00:40:28,410 --> 00:40:32,690 +بيبحثوا على ناس يعطوهم الأموال اللي لديهم عشان + +478 +00:40:32,690 --> 00:40:39,130 +يروحوا يستثمروا فيها فبيعطوها للـ firms الشركات أو + +479 +00:40:39,130 --> 00:40:44,550 +الـ individuals أو + +480 +00:40:44,550 --> 00:40:50,190 +الأشخاص okay it + +481 +00:40:50,190 --> 00:40:56,170 +means the flow of fund الـ fund معناها الأموال the + +482 +00:40:56,170 --> 00:41:01,770 +flow of fund is moving from surplus أنا بسميه + +483 +00:41:01,770 --> 00:41:10,030 +surplus للناس اللي معاهم فائض عن حاجتهم to the + +484 +00:41:10,030 --> 00:41:14,440 +deficit الناس اللي بيحتاجوا هذه الفلوس الشركات + +485 +00:41:14,440 --> 00:41:17,740 +بدها تروح تستثمر وما عندهاش أموال وبالتالي بدها + +486 +00:41:17,740 --> 00:41:21,580 +تاخد من الناس اللي عندهم أموال لذا الـ funds is + +487 +00:41:21,580 --> 00:41:25,880 +moving from the savers to the individuals or firms + +488 +00:41:25,880 --> 00:41:31,240 +يعني الناس اللي مع فلوس بتروح تقرض أو بتعطي للناس + +489 +00:41:31,240 --> 00:41:35,740 +اللي معهم مش فلوس طيب هدول إيش راح يسووا هدول راح + +490 +00:41:40,020 --> 00:41:44,110 +يسووا هيستثمروا في الـ real assets و هتصير عندنا + +491 +00:41:44,110 --> 00:41:49,490 +الدورة بهذا الشكل هتيجي الـ real asset هتعطي income + +492 +00:41:49,490 --> 00:41:53,650 +الـ income جزء منه زي ما حكينا المرة السابقة الـ + +493 +00:41:53,650 --> 00:41:58,150 +consumption و هنسد الـ .. هنسد الـ savers فلوسهم و + +494 +00:41:58,150 --> 00:42:02,810 +القروض تبعتهم okay و هنيجي برضه نروح نقرأ شركات + +495 +00:42:02,810 --> 00:42:07,450 +أخرى وهكذا هذه اسمها الـ circle of economic يعني + +496 +00:42:07,450 --> 00:42:07,890 +كمان مرة + +498 +00:42:11,060 --> 00:42:14,120 +نبدأ خاصة من الـ real assets الـ machines و الـ + +499 +00:42:14,120 --> 00:42:19,780 +equipments تشتغل okay generate goods and services + +500 +00:42:19,780 --> 00:42:23,400 +and + +501 +00:42:23,400 --> 00:42:27,840 +income مظبوط هذا شرحناه المرة الفاتت هلأ هذا ال + +502 +00:42:27,840 --> 00:42:32,760 +income بيصير معانا فلوس بنروح بنعمل consumption + +503 +00:42:32,760 --> 00:42:41,810 +فاكرين و اللي بزيد بنعمله saving صح ال saving اللي + +504 +00:42:41,810 --> 00:42:44,870 +هو الناس اللي بيعملوا .. اللي عندهم savers الناس + +505 +00:42:44,870 --> 00:42:48,090 +اللي عندهم أموال زائدة عن حاجتهم هدول بيسميهم + +506 +00:42:48,090 --> 00:42:52,070 +surplus ناحية اقتصادية بيسميهم surplus يعني عندهم + +507 +00:42:52,070 --> 00:42:57,350 +فائض طيب هدول اللي عندهم فائض بدهم يستثمروا هذا + +508 +00:42:57,350 --> 00:43:02,230 +الفائض و يعطوه لناس بحتاجين للاستثمارات فبيعطيهم + +509 +00:43:02,230 --> 00:43:07,860 +لل firms للشركات Okay الشركات بتروح بتعمل expansion + +510 +00:43:07,860 --> 00:43:11,820 +expansion يعني توسع بتشتري مصانع جديدة و بتعمل + +511 +00:43:11,820 --> 00:43:15,700 +مشاريع و كذا real assets increase in real assets + +512 +00:43:15,700 --> 00:43:19,960 +بعدين بيجيب بيعملوا income بعدين بي .. و بتتعليق + +513 +00:43:19,960 --> 00:43:24,040 +الدورة بالدور إذا واحدة من هالدورة إذا ال machines + +514 +00:43:24,040 --> 00:43:28,880 +weak فشو رح يصير؟ هتوقف الدورة فعشان هيك في الدول + +515 +00:43:28,880 --> 00:43:32,440 +الصناعية في الدول الصناعية الدول اللي بتعتمد على + +516 +00:43:32,440 --> 00:43:37,060 +الصناعة اللي بيصير عندهم انه في ال real estate ال + +517 +00:43:37,060 --> 00:43:39,620 +machines بتشتغل بتعطينا income و بدأ الدورة بتدور + +518 +00:43:39,620 --> 00:43:45,390 +الدول اللي بدأت تعتمد أقل على الصناعة زي مثلا + +519 +00:43:45,390 --> 00:43:48,890 +الأوروبية و ال .. و ال UK و بريطانيا و الدول + +520 +00:43:48,890 --> 00:43:52,950 +الأوروبية هذه صاروا يحاولوا جزء من الصناعة تبعتهم + +521 +00:43:52,950 --> 00:43:56,510 +للصين و ل .. و لدول آسيا ايش اللي راح يصير عندهم + +522 +00:43:56,510 --> 00:44:00,150 +دول الخدمات هتصبح و بالتالي there is no machines و + +523 +00:44:00,150 --> 00:44:02,710 +بالتالي ايش هيصير عندهم؟ هيصير عندهم مشكلة و أزمة + +524 +00:44:02,710 --> 00:44:07,150 +مالية لأن ال machines is not generating income مين + +525 +00:44:07,150 --> 00:44:10,850 +هيصير عندهم ال surplus؟ ال China و الدول الآسية + +526 +00:44:12,020 --> 00:44:16,240 +هيصير عندهم ال machines تشتغل و تجيب لهم income و + +527 +00:44:16,240 --> 00:44:19,420 +هتجيب لهم goods and services و ال income هيروح عند + +528 +00:44:19,420 --> 00:44:22,040 +الناس و يدخروا الفلوس هم يروحوا و يعطوها للشركات و + +529 +00:44:22,040 --> 00:44:25,060 +الشركات هتروح تستثمر و يعملوا expansion و and so + +530 +00:44:25,060 --> 00:44:30,860 +on هذا ال circle okay يعني شوفوا انتوا شو بيصير في + +531 +00:44:30,860 --> 00:44:34,580 +إسبانيا و في إيطاليا و في الدول هذه اللي .. اللي + +532 +00:44:34,580 --> 00:44:38,400 +صار في عندها أزمة مالية لهذا السبب ان ال machines + +533 +00:44:38,400 --> 00:44:45,340 +is not working properly بنجح عند هذا الحد أجرى + +534 +00:44:45,340 --> 00:44:51,280 +ال mode gauges هتفهميها اللي صار في الأزمة المالية + +535 +00:44:51,280 --> 00:44:57,180 +شغل بسيط يعني بدقيقتين خلصت كده اللي هو موضوعنا + +536 +00:44:57,180 --> 00:45:00,520 +اللقاء اللي جاي طبعا مش هركز عليه كتير بس يعني + +537 +00:45:03,860 --> 00:45:09,360 +التركيز بسيط بس بناء .. بناء على سؤالك انه ليش صار + +538 +00:45:09,360 --> 00:45:20,180 +financial crisis financial crisis okay اه الأزمة + +539 +00:45:20,180 --> 00:45:24,140 +المالية financial crisis معناها الأزمة المالية طيب + +540 +00:45:24,140 --> 00:45:27,500 +الأزمة المالية بدت بسبب شغل اسمه ال housing + +541 +00:45:27,500 --> 00:45:35,110 +inflation in housing price زيادة في أسعار البيوت + +542 +00:45:35,110 --> 00:45:39,210 +والمنازل زيادة عن أسعارها الحقيقية هذه موجودة في + +543 +00:45:39,210 --> 00:45:48,190 +الصفحة 14 أسعار + +544 +00:45:48,190 --> 00:45:51,670 +البيوت ني جي هان طلعوا كيف صارت الأزمة + +545 +00:45:57,050 --> 00:45:59,150 +سعر البيوت في الولايات المتحدة الأمريكية و في + +546 +00:45:59,150 --> 00:46:04,050 +بريطانيا و في الدول الأوروبية سعر البيت هذا البيت + +547 +00:46:04,050 --> 00:46:12,510 +okay زي ما تشايفين مثلا سعره seventy thousand + +548 +00:46:12,510 --> 00:46:18,770 +dollar سعره الحقيقي بيسموه effective price اللي + +549 +00:46:18,770 --> 00:46:26,080 +صار نتيجة زيادة الطلب على ال housing و تسهيلات + +550 +00:46:26,080 --> 00:46:29,920 +بالإضافة لتسهيلات الائتمانية الحكومة و تسهيلات + +551 +00:46:29,920 --> 00:46:33,960 +الشركات زاد الطلب على ال housing فال housing صار + +552 +00:46:33,960 --> 00:46:37,580 +إذا سعره سبعين ألف صار يرتفع و بوم و بوم مية و + +553 +00:46:37,580 --> 00:46:45,080 +أشرين ألف دولار سعر الحقيقي كام؟ سبعين و السعر ال + +554 +00:46:45,080 --> 00:46:48,460 +market price مية و أشترين ألف طيب هلأ المستثمرين + +555 +00:46:48,460 --> 00:46:52,920 +الناس اللي ال مثلا الأزواج الجديدة راحت تشتري بيت + +556 +00:46:52,920 --> 00:46:57,400 +دفعت كام مية و أشترين ألف؟ و سأله الحقيقه كام؟ سبع + +557 +00:46:57,400 --> 00:47:03,140 +ألف طيب مين الكفيل للموضوع الحكومة؟ هدول لو فكروا + +558 +00:47:03,140 --> 00:47:07,840 +يبيعوا ال .. + +559 +00:47:07,840 --> 00:47:15,260 +ال حكومة + +560 +00:47:15,260 --> 00:47:20,530 +بتضمن يعني بتعمل ضمانة على القرض يعني ال + +561 +00:47:20,530 --> 00:47:24,070 +collateral يعني مش زي احنا هنا بثقافتنا مثلا بس + +562 +00:47:24,070 --> 00:47:27,710 +خلّي .. إيش اسمك أنت؟ ماي .. ماي مش زي إحنا هتروح + +563 +00:47:27,710 --> 00:47:30,030 +على ال bank يحكولك أعطيني اثنين كفيل هذا الكلام + +564 +00:47:30,030 --> 00:47:33,410 +تقريبا مش موجود عندهم، ايش اللي بيصير؟ لأن هدول + +565 +00:47:33,410 --> 00:47:38,730 +أزواج شابة، تمام؟ ففيش مين بيكفلهم؟ بيكفلهم + +566 +00:47:38,730 --> 00:47:43,030 +الحكومة يعني في حال أنه صار في default يعني + +567 +00:47:43,030 --> 00:47:46,940 +ماقدروش يدفعوا، مين اللي بيدفع عنهم؟ الحكومة طيب + +568 +00:47:46,940 --> 00:47:50,660 +هلأ السعر مية و عشرين ألف لو هدول الأزواج فكروا + +569 +00:47:50,660 --> 00:47:55,220 +بلي ببيعوا ببيعوا ال house تبعهم بكم هيبيعوه؟ + +570 +00:47:55,220 --> 00:47:58,440 +سبعين ألف هيبيعوه لإنه صار في drop في اللي + +571 +00:47:58,440 --> 00:48:01,560 +هيبيعوه بسبعين ألف طب ال خمسين ألف هذه خسارة لهم + +572 +00:48:01,560 --> 00:48:06,460 +مظبوط ولا لأ؟ وبالتالي صاروا ايش يسووا هدول؟ اي + +573 +00:48:06,460 --> 00:48:07,840 +بطلوا يدفعوا الفلوس تبعتهم + +574 +00:48:10,940 --> 00:48:14,460 +لأنه صار في over valued لل housing صار أسعار مائة + +575 +00:48:14,460 --> 00:48:17,560 +و عشرين ألف و هو سعره الحقيقي سبعين ألف و بالتالي + +576 +00:48:17,560 --> 00:48:22,560 +صاروا يخفضوا دفعهم و المشاكل في أقلية الدفاع + +577 +00:48:22,560 --> 00:48:26,440 +فمين بيضغط الموضوع ال governments طب ال + +578 +00:48:26,440 --> 00:48:30,420 +governments شو هتسوي هتدفع هتبدأ تغطي ال block ال + +579 +00:48:30,420 --> 00:48:35,120 +government مفترض عندها عندها خمسة مليون okay مفترض + +580 +00:48:35,120 --> 00:48:39,000 +عندها خمسة مليون okay هدول خمسة مليون محتوطين في + +581 +00:48:39,000 --> 00:48:43,220 +ميزان المدفوعات هتدفع جزء منهم لمين؟ هتدفع جزء + +582 +00:48:43,220 --> 00:48:48,920 +منهم ل ال houses طب و في شغلات لل hospitals و في + +583 +00:48:48,920 --> 00:48:51,780 +شغلات لل insurance و في شغلات يعني للمستشفيات ده + +584 +00:48:51,780 --> 00:48:54,900 +تدفع و ل ال insurance هتدفع و ل الموظفين هتدفع و + +585 +00:48:54,900 --> 00:49:00,340 +كل شيء فبتروح ايش بتسوي؟ بتخفض نسب دعم الطبقات + +586 +00:49:00,340 --> 00:49:03,020 +الأخرى فبيبدأ الاقتصاد يشنزر و بيصير عندنا أزمة + +587 +00:49:03,020 --> 00:49:05,920 +مالية و بيصيروا يستغلوا على الموظفين و بيصيروا + +588 +00:49:05,920 --> 00:49:10,340 +مايدفعوش مثلا لل .. لل .. بيشتغلوا في ال .. ال .. + +589 +00:49:10,340 --> 00:49:14,060 +مثلا كبار السن و بيصير عندك أزمة مالية طبعا هذه ب + +590 +00:49:14,060 --> 00:49:20,300 +.. بحدود بسيط بعدك الأزمة وصلت لمراحل متقدمة ماشي + +591 +00:49:20,300 --> 00:49:21,280 +انتهت عند هذا الحد diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/a8rBMzpxgGc.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/a8rBMzpxgGc.srt new file mode 100644 index 0000000000000000000000000000000000000000..8b3129835b40675957b7f42078d619d072a8f303 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/a8rBMzpxgGc.srt @@ -0,0 +1,1207 @@ +1 +00:00:21,800 --> 00:00:24,640 +المحاضرة اللي فاتت احنا حكينا عن الـ syllabus تبع + +2 +00:00:24,640 --> 00:00:27,880 +المادة and what you have to do in the... during + +3 +00:00:27,880 --> 00:00:33,160 +the class okay وشوفنا مع بعض how to download the + +4 +00:00:33,160 --> 00:00:36,860 +chapters and syllabus from the website طبعا هلأ + +5 +00:00:36,860 --> 00:00:41,460 +بدنا نحكي عن الـ chapter one الـ chapter one بيحكي + +6 +00:00:41,460 --> 00:00:43,380 +عن الـ investment environment اللي هو بيئة + +7 +00:00:43,380 --> 00:00:47,500 +الاستثمار بيئة الاستثمار بتغطي ثلاث مواضيع أساسية + +8 +00:00:47,500 --> 00:00:51,420 +قبل ما ندخل بالتفاصيل، الموضوع الأول what it means + +9 +00:00:51,420 --> 00:00:55,400 +investments which includes financial assets and + +10 +00:00:55,400 --> 00:00:58,320 +real assets بدنا نفرق بين الـ financial asset + +11 +00:00:58,320 --> 00:01:02,340 +الأصول المالية و الأصول الحقيقية the relationship + +12 +00:01:02,340 --> 00:01:06,880 +between financial markets and economic العلاقة بين + +13 +00:01:06,880 --> 00:01:08,780 +الـ financial market و الـ economics يعني علاقة + +14 +00:01:08,780 --> 00:01:12,360 +الأسواق المالية بالاقتصاد okay and we will talk + +15 +00:01:12,360 --> 00:01:14,680 +about the regulations of financial markets بعض الـ + +16 +00:01:14,680 --> 00:01:18,110 +crisis and regulations of the financial markets if + +17 +00:01:18,110 --> 00:01:21,110 +we are not follow up the regulations, what's + +18 +00:01:21,110 --> 00:01:22,550 +happening in the financial market؟ إذا احنا ما + +19 +00:01:22,550 --> 00:01:25,290 +بنطبق التعليمات، شو ممكن يصير في الـ financial + +20 +00:01:25,290 --> 00:01:28,290 +market؟ So first of all what it means investment؟ + +21 +00:01:28,290 --> 00:01:31,950 +ممكن تعليقنا، إيش تفسيرك لـ investment؟ هي current + +22 +00:01:31,950 --> 00:01:35,010 +commitment of money or other resources in this + +23 +00:01:35,010 --> 00:01:40,390 +vision of reaping... reaping... reaping... okay... + +24 +00:01:40,390 --> 00:01:46,300 +okay يعني إنه احنا التخلي عن المنفعة الحالية للحصول + +25 +00:01:46,300 --> 00:01:51,180 +على عائد في المستقبل، مثلا ان انا معايا فلوس الآن + +26 +00:01:51,180 --> 00:01:55,960 +okay هدول الفلوس بروح أعملهم استثمار، فانا اتخلت عن + +27 +00:01:55,960 --> 00:02:00,120 +منفعة استخدام الفلوس عشان يجيبولي عائد في المستقبل + +28 +00:02:00,120 --> 00:02:05,660 +يعني في المستقبل يجيبولي أرباح معينة، أستثمرهم + +29 +00:02:05,660 --> 00:02:08,800 +بقطعة أرض، وقطعة أرض في المستقبل أروح أبيعها في + +30 +00:02:08,800 --> 00:02:11,820 +تجيبلي عائد، فانا اتخلت عن منفعة حاليا لحصول على + +31 +00:02:11,820 --> 00:02:26,190 +منفعة مستقبل، هي هذا المعنى الاستثمار، Okay لأ + +32 +00:02:26,190 --> 00:02:29,850 +exactly + +33 +00:02:29,850 --> 00:02:34,070 +يعني مثل ما اتفضلتِ لما احنا بنتخلى عن منفعة + +34 +00:02:34,070 --> 00:02:39,610 +حالية للحصول على منفعة أكبر في المستقبل، إذا بنعدل + +35 +00:02:39,610 --> 00:02:44,030 +التعريف مش ف... بس الحصول to get benefit from the + +36 +00:02:44,030 --> 00:02:49,340 +future return is to maximize the future return، ان + +37 +00:02:49,340 --> 00:02:52,920 +احنا نعظم المنفعة المستقبلي، يعني انا مثلا معايا الـ 1000 + +38 +00:02:52,920 --> 00:02:58,120 +دولار اليوم، اشتريت فيهم أصول، هذه الأصول انا اتخلت + +39 +00:02:58,120 --> 00:03:02,540 +عن الـ 1000 دولار، ممكن اروح اكل فيهم، ممكن اشتري شغلات + +40 +00:03:02,540 --> 00:03:05,600 +انا استخدمها، لكن اتخلت فيهم عشان استثمر واشتريت + +41 +00:03:05,600 --> 00:03:10,380 +مثلا قطعة أرض أو اشتريت أسهم، في المستقبل هيجيني + +42 +00:03:10,380 --> 00:03:14,680 +عائد، هذا العائد متوقع يكون أكبر من قيمة الـ 1000 دولار + +43 +00:03:15,660 --> 00:03:21,680 +فهذا هو تعريف الاستثمار، الـ investment + +44 +00:03:21,680 --> 00:03:24,280 +environment، الـ environment هي البيئة المحيطة + +45 +00:03:24,280 --> 00:03:27,420 +بالاستثمار، الـ regulations، الأدوات المالية اللي + +46 +00:03:27,420 --> 00:03:34,060 +احنا بنستثمر فيها، التعليمات الحكومية اللي بتخلينا + +47 +00:03:34,060 --> 00:03:38,900 +نتنظم عملية الاستثمار، أهم + +48 +00:03:38,900 --> 00:03:44,420 +عوامل في بيئة الاستثمار is to understand the real + +49 +00:03:44,420 --> 00:03:48,500 +assets versus financial assets، لازم نفهم شو الفرق + +50 +00:03:48,500 --> 00:03:51,900 +بين الـ real assets و بين الـ financial assets، شو + +51 +00:03:51,900 --> 00:03:55,920 +معنى الـ real assets، أصول حقيقية، أعطوني مثال عن + +52 +00:03:55,920 --> 00:04:03,640 +أصول حقيقية، أرض، مظبوط، مباني، machines، equipments + +53 +00:04:03,640 --> 00:04:10,980 +ممكن إذا صنعناها صح؟ البنات اللي وراها... إيش + +54 +00:04:10,980 --> 00:04:17,620 +رأيكم؟ سيارات، صح؟ أرضي + +55 +00:04:17,620 --> 00:04:26,600 +... lands ممكن بس مش دقيق كتير، okay، ممكن مش دقيق + +56 +00:04:26,600 --> 00:04:32,430 +يعني هي أشياء it's help الـ knowledge... إيش الـ + +57 +00:04:32,430 --> 00:04:37,910 +knowledge؟ كيف... كيف ننقصها هذه الـ knowledge؟ عن + +58 +00:04:37,910 --> 00:04:42,590 +مين موجودة الـ knowledge هذه؟ ايوا بالظبط الـ + +59 +00:04:42,590 --> 00:04:46,590 +knowledge... الـ knowledge is considered as a real + +60 +00:04:46,590 --> 00:04:51,130 +asset وهذه بيسموها بال... بال... بالـ accounting + +61 +00:04:51,130 --> 00:04:55,270 +intellectual property، اسمها إيش؟ intellectual + +62 +00:04:55,270 --> 00:04:59,090 +property اللي هو حقوق الملكية و حقوق الفكرية هذه + +63 +00:04:59,090 --> 00:05:02,330 +بنعتبرها real assets sometimes... sometimes you + +64 +00:05:02,330 --> 00:05:06,070 +get confused between what is real asset and what + +65 +00:05:06,070 --> 00:05:09,650 +is financial asset في بعض الناس بيفكروا الـ + +66 +00:05:09,650 --> 00:05:12,570 +financial... الـ real asset هي ال... is to be + +67 +00:05:12,570 --> 00:05:18,470 +touched اللي احنا بنلمسها، لأ مش هذه تعريفها، مش هي + +68 +00:05:18,470 --> 00:05:22,650 +يعني ممكن الـ copyright تكون... تكون real asset، الـ + +69 +00:05:22,650 --> 00:05:25,450 +knowledge، الـ intellectual property ك... احنا ممكن + +70 +00:05:25,450 --> 00:05:32,420 +نمسك الـ knowledge وبالتالي هذه real assets، الـ real + +71 +00:05:32,420 --> 00:05:36,020 +assets زي ما احنا هنيجي نعرفها تتعمل لـ productive + +72 +00:05:36,020 --> 00:05:40,540 +capacity and net income of the economy، من هذه الـ + +73 +00:05:40,540 --> 00:05:44,640 +real assets الدخل + +74 +00:05:44,640 --> 00:05:47,620 +الحقيقي للاقتصاد بييجي، يعني الاقتصاد من وين + +75 +00:05:47,620 --> 00:05:51,780 +بيستفيد؟ بيستفيد من الـ real assets وليس من الـ + +76 +00:05:51,780 --> 00:05:56,730 +financial assets، الاقتصاد ليش؟ الـ equipments إيش + +77 +00:05:56,730 --> 00:06:02,030 +بتطلعلي؟ الـ equipments و الـ machines بتطلعلي سلع و + +78 +00:06:02,030 --> 00:06:05,350 +بنروح هذه السلع بنبيعها و بالتالي بيصير عندي + +79 +00:06:05,350 --> 00:06:08,690 +income، إذا هذه الـ machines produce goods and + +80 +00:06:08,690 --> 00:06:12,590 +services then we sell these goods and services and + +81 +00:06:12,590 --> 00:06:16,630 +we get income so the economy is get benefited from + +82 +00:06:16,630 --> 00:06:21,630 +using the fixed asset، يعني الاقتصاد بيستفيد من الـ + +83 +00:06:21,630 --> 00:06:25,970 +fixed asset، Okay؟ So the term is the productive + +84 +00:06:25,970 --> 00:06:30,350 +capacity، ممكنية الإنتاج and net income of the + +85 +00:06:30,350 --> 00:06:35,510 +economy، يعني بتعمل شغلتين، تنتج وتجيب لإيراد، هذا + +86 +00:06:35,510 --> 00:06:38,310 +بالنسبة لإيش الـ real asset، إذا إحنا طبقنا الكلام + +87 +00:06:38,310 --> 00:06:41,650 +هذا بنقدر نقول هذا real asset أو not real asset + +88 +00:06:41,650 --> 00:06:48,110 +واضح الكلام هذا؟ إذا واضح إنه real asset، إذا الـ + +89 +00:06:48,110 --> 00:06:51,110 +real asset مش بس machines، مش بس equipments، ممكن + +90 +00:06:51,110 --> 00:06:52,710 +تكون شغلات تانية، هنسأل فيها كم شوية + +91 +00:06:56,410 --> 00:07:00,090 +أمثلة اللي انتوا حاكيتوها، lands, buildings, + +92 +00:07:00,210 --> 00:07:02,270 +machines, knowledge used to produce goods and + +93 +00:07:02,270 --> 00:07:06,950 +services وفي شغلات تانية احنا we leave it just to + +94 +00:07:06,950 --> 00:07:09,930 +examine your understanding، يعني في شغلات تانية + +95 +00:07:09,930 --> 00:07:15,590 +هنشوف activity فيها تتعرف على new real assets، مش + +96 +00:07:15,590 --> 00:07:18,830 +واضحة علنا واحنا هنوضحها، طب نشوف الـ financial + +97 +00:07:18,830 --> 00:07:22,230 +assets، الـ financial assets a claims on real assets + +98 +00:07:22,230 --> 00:07:29,680 +في حد بيعرف what it means this؟ البنات الجانب هذا + +99 +00:07:29,680 --> 00:07:35,140 +بتشتغلوا معانا اه؟ شوفوا إذا أهمية بنات أهميتهم ان + +100 +00:07:35,140 --> 00:07:40,680 +انتوا تقرأوا قبل ما تيجوا عشان انا بعرف وين ال... + +101 +00:07:40,680 --> 00:07:42,920 +وين ال... الـ weaknesses point، وين الـ strength + +102 +00:07:42,920 --> 00:07:47,760 +point عندكم وبتعلم، ممكن نسهل عملية الشرح اه؟ + +103 +00:07:52,080 --> 00:07:57,100 +من وين أجدت هذه؟ من النبع، من الأصول الحقيقية + +104 +00:07:57,100 --> 00:08:02,020 +بالظبط، صح، يعني الـ financial assets are claims on + +105 +00:08:02,020 --> 00:08:06,360 +real assets، يعني هي التزامات ناتجة عن الأصول + +106 +00:08:06,360 --> 00:08:10,740 +الحقيقية، يعني مثلا في حد بيقدر يعطيني مثال كيف how + +107 +00:08:10,740 --> 00:08:15,400 +the how the financial how the real assets generate + +108 +00:08:15,400 --> 00:08:19,480 +financial assets، مش هيك، claims on real assets it + +109 +00:08:19,480 --> 00:08:23,060 +means the real assets generate financial assets + +110 +00:08:23,060 --> 00:08:27,200 +يعني مين أبو الـ financial assets؟ هي الـ real + +111 +00:08:27,200 --> 00:08:31,740 +assets، فإذن the real assets the... the... the + +112 +00:08:31,740 --> 00:08:35,180 +financial asset is not coming from nothing it is + +113 +00:08:35,180 --> 00:08:39,400 +not coming from itself، ما اجت من نفسها، it comes + +114 +00:08:39,400 --> 00:08:43,960 +from the real assets، اجت من الـ real assets، هعطوني + +115 +00:08:43,960 --> 00:08:48,830 +مثال على الكلام هذا، اتفضلي، طب نصنعها نستخدم في + +116 +00:08:48,830 --> 00:08:51,730 +إنتاج... ننتج... ننتج سلاح، لما نبيعها نحصل على + +117 +00:08:51,730 --> 00:08:55,290 +الأموال، طيب وين الـ financial asset اللي اندوالها + +118 +00:08:55,290 --> 00:09:02,390 +ده تجديد؟ سيارات؟ لأ، مش كتير الـ example، انت بدأت + +119 +00:09:02,390 --> 00:09:08,230 +صح بس بالأخير ما... وين الـ financial asset؟ how... + +120 +00:09:08,230 --> 00:09:12,290 +how the real assets generate financial assets؟ + +121 +00:09:12,290 --> 00:09:14,550 +اتفضلي، الأموال اللي نبتشت في السلاح + +122 +00:09:19,040 --> 00:09:23,460 +Okay، تقريبا يمكننا نعطي مثال زي ما انت حكيت المثال + +123 +00:09:23,460 --> 00:09:29,060 +إيش اسمك؟ اسمها، اسمها أعطتنا مثال، مثلا اشترينا + +124 +00:09:29,060 --> 00:09:36,940 +machines، machine آلة، هاي الآلة اشتريناها، okay + +125 +00:09:36,940 --> 00:09:44,240 +هذه الـ machine احنا أمامنا خيارين، يا أما ندفع cash + +126 +00:09:45,580 --> 00:09:54,460 +يا إما ناخد قرض صح؟ نشتري آلة يا إما معانا + +127 +00:09:54,460 --> 00:09:57,920 +فلوس بجيبتنا بنشتري الـ machine يا إما ما عندناش فلوس + +128 +00:09:57,920 --> 00:10:00,180 +بنروح على البنك الإسلامي ولا بنروح على البنوك هاي + +129 +00:10:00,180 --> 00:10:05,420 +وبنروح ناخد قرض أو مرابحة أو .. هذا القرض هو real + +130 +00:10:05,420 --> 00:10:09,740 +asset ولا financial asset؟ من وين إجا؟ إجا لأنه + +131 +00:10:09,740 --> 00:10:13,540 +اشترينا machine إذا because of using the machines + +132 +00:10:13,540 --> 00:10:17,650 +because of buying the machines the machines generate + +133 +00:10:17,650 --> 00:10:23,230 +loans هي طلعت لي الـ loans وإلا لو احنا ما اشتريناش + +134 +00:10:23,230 --> 00:10:29,150 +machines ليش بيلزم القرض؟ إذا الماكينة هذه لما + +135 +00:10:29,150 --> 00:10:35,310 +اشترناها أخدنا قرض عشان نشتريها هذا القرض هو عبارة + +136 +00:10:35,310 --> 00:10:40,010 +عن financial assets عبارة عن أصول مالية طيب طريقة + +137 +00:10:40,010 --> 00:10:52,650 +ثانية فضله اه خليني أسمعها طبعا .. بالظبط .. + +138 +00:10:52,650 --> 00:11:01,240 +صح .. تاخد قرض أو تطرح أسهمهم .. بالظبط .. buying + +139 +00:11:01,240 --> 00:11:06,260 +the land or building or starting of a project need + +140 +00:11:06,260 --> 00:11:11,740 +to issue shares or bonds or loans فلأن أن أنت بدك + +141 +00:11:11,740 --> 00:11:15,640 +تشتري الأرض و تعمل مشروع فبدك تضطري تطرحي أسهم بدك + +142 +00:11:15,640 --> 00:11:19,540 +تضطري تطرحي سندات أو تاخدي قرض فهدول اللي عملوه + +143 +00:11:19,540 --> 00:11:22,580 +generate لإيش؟ لـ financial assets طب نيجي نسأل + +144 +00:11:22,580 --> 00:11:25,980 +السؤال الـ income الحقيقي بيجي من وين؟ من الـ real + +145 +00:11:25,980 --> 00:11:29,000 +assets ولا من الـ financial assets؟ من الـ real + +146 +00:11:29,000 --> 00:11:34,450 +assets إذا الحقيقة هيجي من وين؟ أنا أصلا كانت Indie + +147 +00:11:34,450 --> 00:11:38,610 +Art بالظبط من الـ real asset لأن الـ real asset أنت + +148 +00:11:38,610 --> 00:11:41,530 +هتعمل المصنع و الـ machines producing goods and + +149 +00:11:41,530 --> 00:11:45,230 +services و الـ goods and services will be sold in + +150 +00:11:45,230 --> 00:11:48,950 +the markets so it generates income and the income + +151 +00:11:48,950 --> 00:11:53,650 +recover الـ loans شفتوا كيف الـ cycle هتمشي؟ يعني + +152 +00:11:53,650 --> 00:11:56,970 +هذه الـ machines اللي احنا اشتريناها هتعمل producing + +153 +00:11:56,970 --> 00:12:00,530 +لإيش؟ لـ goods and services الـ goods and services + +154 +00:12:00,530 --> 00:12:04,410 +نعملها صالب في السوق بتعملني income الـ income + +155 +00:12:04,410 --> 00:12:09,990 +بيسكبلي الـ loans who generates the income؟ the + +156 +00:12:09,990 --> 00:12:19,010 +real assets فضل claims on real + +157 +00:12:19,010 --> 00:12:24,020 +assets التزامات على الأصول الثابتة مثلها ده اه أنا + +158 +00:12:24,020 --> 00:12:28,380 +برأيي إن الـ real assets claim on financial يعني الـ + +159 +00:12:28,380 --> 00:12:31,840 +real asset هي اللي بتسدد الـ .. اه لإنه جد لإن الـ + +160 +00:12:31,840 --> 00:12:34,620 +financial احنا أخدنا قرض و بتفتح لي القرض هو + +161 +00:12:34,620 --> 00:12:38,400 +financial asset و شرينا منك يعني القرض أعلى، + +162 +00:12:38,400 --> 00:12:40,420 +الأعلى هي الـ real asset دي بقى و مين اللي بيبقى + +163 +00:12:40,420 --> 00:12:44,440 +عالمي okay هلا بنيجي الـ .. الـ machines هي اللي + +164 +00:12:44,440 --> 00:12:48,640 +producing the goods and services ولا القرض طب + +165 +00:12:48,640 --> 00:12:52,480 +خلينا ناخد .. بدناش machines و نحكي للقرض please + +166 +00:12:52,480 --> 00:12:58,020 +generate goods and services we can do it we cannot + +167 +00:12:58,020 --> 00:13:03,260 +do it because loans cannot create income الـ loans + +168 +00:13:03,260 --> 00:13:08,540 +ما بيعطونيش income a real income هاي بيعطي interest + +169 +00:13:08,540 --> 00:13:15,940 +interest as a compensation of the utility هو نتيجة + +170 +00:13:15,940 --> 00:13:25,040 +عن تعويض للمنفعة المستقبلية وليس بسبب استخدامنا للـ + +171 +00:13:25,040 --> 00:13:28,940 +machines طيب إذا الـ machines اللي اشتريناها هي + +172 +00:13:28,940 --> 00:13:32,340 +اللي هتعمل لي goods and services وبعدين احنا هنغطي + +173 +00:13:32,340 --> 00:13:37,040 +الـ loans و and the cycle is going in this way لأن + +174 +00:13:37,040 --> 00:13:42,460 +احنا لو حاجت لأن مش عايشة أكثر .. بالظبط .. that's + +175 +00:13:42,460 --> 00:13:46,480 +it يعني both of you are right يعني أنتو الاتنين + +176 +00:13:46,480 --> 00:13:51,860 +صحيح إن الـ the .. the fixed assets generate a + +177 +00:13:51,860 --> 00:13:56,620 +real .. a real income بس هاي الـ loans is a + +178 +00:13:56,620 --> 00:14:00,160 +compensation لأن احنا هندفع بالـ loan شغلتين أو في + +179 +00:14:00,160 --> 00:14:04,420 +المرابحة هندفع شغلتين هندفع اللي هو الـ .. الـ .. + +180 +00:14:04,420 --> 00:14:08,360 +the value of .. of .. of .. of loan plus the + +181 +00:14:08,360 --> 00:14:13,420 +interest الـ interest why the interest is the + +182 +00:14:13,420 --> 00:14:16,640 +compensation for investors احنا بنعوضهم لأنهم + +183 +00:14:16,640 --> 00:14:21,640 +اتنازلوا عن المنفعة الحالية لمنفعة مستقبلية بس بس + +184 +00:14:21,640 --> 00:14:26,440 +الـ machines هي الأساس اللي هتعطيني الـ generate the + +185 +00:14:26,440 --> 00:14:33,360 +income and if this if the machine stop working it + +186 +00:14:33,360 --> 00:14:37,730 +means we cannot pay back the loans نقدرش احنا + +187 +00:14:37,730 --> 00:14:41,290 +هنسيبنا الـ loans إذا مين بيعمل generation للـ + +188 +00:14:41,290 --> 00:14:48,610 +income؟ if the real assets stop working مش + +189 +00:14:48,610 --> 00:14:52,650 +هنقدر نعمل و زي ما صار بالـ mortgages مش هندخل فيها + +190 +00:14:52,650 --> 00:14:58,750 +لما نيجي نحكي في الموضوع تبعها okay؟ + +191 +00:14:58,750 --> 00:15:00,730 +في حد عنده سؤال what is the difference between + +192 +00:15:00,730 --> 00:15:03,810 +real assets and financial assets؟ exam is of + +193 +00:15:03,810 --> 00:15:07,100 +financial assets أمثلة على الـ financial assets + +194 +00:15:07,100 --> 00:15:16,060 +bonds loans stocks أسهم ايش فيه كمان treasure + +195 +00:15:16,060 --> 00:15:20,200 +bills CDs we have thousands of financial assets + +196 +00:15:20,200 --> 00:15:24,060 +هيكون في عندي chapter كامل بس بيعمل لي listing لهذه + +197 +00:15:24,060 --> 00:15:29,060 +الـ financial assets okay نيجي على الـ financial + +198 +00:15:29,060 --> 00:15:33,440 +assets three types there are three main types of + +199 +00:15:33,440 --> 00:15:36,900 +financial assets ثلاث أنواع أساسية للـ financial + +200 +00:15:36,900 --> 00:15:43,660 +assets okay fixed income or debts في financial + +201 +00:15:43,660 --> 00:15:54,060 +asset بتعطيني fixed income ثابت عائد ثابت طبعا حد + +202 +00:15:54,060 --> 00:15:58,500 +يعطيني مثال على financial asset بتعطيني عائد ثابت + +203 +00:15:58,500 --> 00:16:08,840 +زي إيش السندات صح القروض صح الأسهم ممتازة صح، إذا + +204 +00:16:08,840 --> 00:16:12,820 +هاي عندنا الـ bonds, preferred stocks و الـ loans, + +205 +00:16:13,460 --> 00:16:18,040 +treasury bills, CDs كلهم هدول بيعطوني ايه؟ بيعطوني + +206 +00:16:18,040 --> 00:16:24,240 +fixed income لكن في مشاكل إن احنا نحصل على fixed + +207 +00:16:24,240 --> 00:16:28,260 +income okay + +208 +00:16:28,260 --> 00:16:33,520 +هنيجي نحكي في الموضوع النوع الثاني الـ common stocks + +209 +00:16:33,520 --> 00:16:37,700 +common stock or equity الـ common stock or equity + +210 +00:16:37,700 --> 00:16:44,620 +اللي هو الأسهم العادية أو حقوق الملكية يعني + +211 +00:16:44,620 --> 00:16:46,780 +في ناس بيسموها common stock و في ناس بيسموها + +212 +00:16:46,780 --> 00:16:51,730 +equity لأن ممكن ندخل الـ dividends عارفين الأسهم + +213 +00:16:51,730 --> 00:16:54,770 +العادية طبعا بالـ financial management أخدتوا أنتو + +214 +00:16:54,770 --> 00:16:57,030 +what it means common stock what is the difference + +215 +00:16:57,030 --> 00:16:59,290 +between common stock and preferred stocks الفروقات + +216 +00:16:59,290 --> 00:17:01,830 +بين الـ common stock و الـ preferred stocks واضحة + +217 +00:17:01,830 --> 00:17:08,750 +عندكم؟ okay derivative securities هاد الموضوع شوية + +218 +00:17:08,750 --> 00:17:12,090 +في حد سمع بالـ derivative securities قبل هك؟ + +219 +00:17:15,960 --> 00:17:18,820 +الأوراق المالية هي الـ high financial asset الأوراق + +220 +00:17:18,820 --> 00:17:24,100 +المالية derivatives مشتقات اسمها مشتقات what is + +221 +00:17:24,100 --> 00:17:27,420 +the story of derivatives؟ شو هي الـ derivatives؟ + +222 +00:17:27,420 --> 00:17:30,740 +and from where the derivatives come from؟ من وين + +223 +00:17:30,740 --> 00:17:34,800 +إجت الـ derivatives؟ + +224 +00:17:34,800 --> 00:17:43,840 +بسيطة احنا خلينا نبدأ الـ story من بدايتها we agree + +225 +00:17:43,840 --> 00:17:50,060 +that real assets generate financial assets، مظبوط؟ + +226 +00:17:50,060 --> 00:17:55,240 +إذا real assets generate + +227 +00:17:55,240 --> 00:17:58,480 +financial assets، abbreviation for financial + +228 +00:17:58,480 --> 00:18:05,680 +assets okay financial assets generate derivatives + +229 +00:18:05,680 --> 00:18:10,280 +what + +230 +00:18:10,280 --> 00:18:16,070 +it means derivatives مشتقات it means derivatives is + +231 +00:18:16,070 --> 00:18:21,130 +derived from the prices of financial assets يعني + +232 +00:18:21,130 --> 00:18:23,650 +الـ derivatives هي مشتقة من أسعار الـ financial + +233 +00:18:23,650 --> 00:18:31,410 +assets so the investors and derivatives drive + +234 +00:18:31,410 --> 00:18:35,950 +transactions or drive investments on the prices of + +235 +00:18:35,950 --> 00:18:39,950 +financial assets how it comes؟ كيف هذا الكلام + +236 +00:18:39,950 --> 00:18:47,170 +بيصير؟ مثال بسيط derivatives includes three types + +237 +00:18:47,170 --> 00:18:52,570 +option future + +238 +00:18:52,570 --> 00:19:04,330 +and swap okay let's take example of the option and + +239 +00:19:04,330 --> 00:19:06,850 +how the option is derived from the financial + +240 +00:19:06,850 --> 00:19:13,010 +assets as we agree before the common stock is one + +241 +00:19:13,010 --> 00:19:14,930 +of the financial assets واحدة من الـ financial + +242 +00:19:14,930 --> 00:19:20,430 +assets okay إذا هاي stock هاي financial assets هلا + +243 +00:19:20,430 --> 00:19:25,690 +بنعمل drive لـ financial لـ derivatives ناخد الـ + +244 +00:19:25,690 --> 00:19:31,170 +option سعر الـ stock في السوق نفترض عشرين دولار + +245 +00:19:31,170 --> 00:19:36,100 +سعره في السوق عشرين دولار إذا نعيد تعريف الـ + +246 +00:19:36,100 --> 00:19:39,480 +derivatives is derived from the prices of the + +247 +00:19:39,480 --> 00:19:43,940 +financial assets بس احنا موضوعنا بس لـ prices بيجي + +248 +00:19:43,940 --> 00:19:48,960 +واحد من المستثمرين بيحكي إن أنا بدي أشري السهم + +249 +00:19:48,960 --> 00:19:55,300 +هذا بعد تلت شهور بدي أشري بعد تلت شهور طيب بعد تلت + +250 +00:19:55,300 --> 00:20:02,980 +شهور احتمال السعر يطلع واحتمال ينزل فعشان + +251 +00:20:02,980 --> 00:20:06,540 +هما يصيرش عنده مشكلة في الاستثمار بروح على + +252 +00:20:06,540 --> 00:20:10,260 +derivatives derivatives derivatives بتسهل له عملية + +253 +00:20:10,260 --> 00:20:15,460 +fixing the price بتعمله ايش fixing the price تثبيت + +254 +00:20:15,460 --> 00:20:21,340 +السعر تثبيت السعر مقابل premium مقابل ايش premium + +255 +00:20:21,340 --> 00:20:25,060 +يعني علاوة بروح بيحكوا لهم okay السعر الآن عشرين + +256 +00:20:25,060 --> 00:20:29,100 +دولار أنا بدي أثبت السعر لأنه بدي أشتري هذا السهم + +257 +00:20:29,100 --> 00:20:34,380 +بعد ثلاث شهور فبيقولوا له okay بتدفع two dollar هدول + +258 +00:20:34,380 --> 00:20:38,600 +ال premium هو هيدفع فقط two dollar مش هيدفع عشرين + +259 +00:20:38,600 --> 00:20:45,720 +والعشرين مدى هيدفعهم بعد ثلاث شهور ما دفع + +260 +00:20:45,720 --> 00:20:51,420 +عشان ساعتها وعشرين دفع كام بالظبط كلامك صح طيب هلأ + +261 +00:20:51,420 --> 00:20:55,880 +ناخد احتمالين ناخد two options this is why this is + +262 +00:20:55,880 --> 00:21:00,210 +optionالفرصة الأولى هو أن السعر يظل يظل يظل يظل + +263 +00:21:00,210 --> 00:21:03,030 +يظل يظل يظل يظل يظل يظل يظل يظل يظل يظل + +264 +00:21:03,030 --> 00:21:07,790 +يظل يظل يظل يظل يظل يظل يظل يظل يزل يزل + +265 +00:21:07,790 --> 00:21:13,990 +يزل يزل يزل يزل يزل يزل + +266 +00:21:13,990 --> 00:21:14,790 +يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل + +267 +00:21:14,790 --> 00:21:14,850 +يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل + +268 +00:21:14,850 --> 00:21:23,590 +يزل يزل يزل يزل يز + +269 +00:21:23,680 --> 00:21:28,160 +and he or she saw the price twenty five شو راح + +270 +00:21:28,160 --> 00:21:34,040 +يسوي ال investors في الحالة الأولى هو ثبته على + +271 +00:21:34,040 --> 00:21:37,880 +عشرين هيدفع ال premium two دولار وسعره في السوق + +272 +00:21:37,880 --> 00:21:40,880 +خمسة وعشرين دولار شو راح يسوي ال investors هيدفع + +273 +00:21:40,880 --> 00:21:44,300 +عشرين و two premium هيدفع اثنين وعشرين المستثمر + +274 +00:21:44,300 --> 00:21:49,980 +كام ربح ثلاثة دولار في ال case الأولى three + +275 +00:21:49,980 --> 00:21:50,400 +dollars + +276 +00:21:53,040 --> 00:21:57,640 +أه هلا احنا في عندنا ثبتنا السعر عشرين في premium + +277 +00:21:57,640 --> 00:22:00,880 +العربون احنا بالعربي بنسميها عربون صح؟ يعني أنت + +278 +00:22:00,880 --> 00:22:03,960 +بدك تشتري بيت وماعندك فلوس فبتقول للرجل خد + +279 +00:22:03,960 --> 00:22:07,080 +هاي عربون وأنا بعد ثلاث شهور هابعتلك الفلوس إذا + +280 +00:22:07,080 --> 00:22:12,620 +ما جبت ال cash الفلوس بروح عليّ ايش العربون فهما كيف + +281 +00:22:12,620 --> 00:22:17,740 +يعني هاي مثال بالإن بالبلد طيب هلأ نيجي ال .. + +282 +00:22:17,740 --> 00:22:23,850 +السعر خمسة وعشرين دولار في ال $2 هيدفعها من عربون و + +283 +00:22:23,850 --> 00:22:29,190 +$20 فصاروا 22 المفروض بدون هيدفع في السوق سعر السهم + +284 +00:22:29,190 --> 00:22:34,570 +أو سعر السهم 25$ فهم ثبته يعني ثبت سعره خلاص هيدفع + +285 +00:22:34,570 --> 00:22:38,270 +ال 20 و ال $2 premium هي 22 لو حابب يبيعه في نفس + +286 +00:22:38,270 --> 00:22:44,030 +اللحظة بيعمل 3$ في كل سهم واضح طيب هلأ ناخد ال + +287 +00:22:44,030 --> 00:22:49,050 +opposite ناخد العكس ناخد العكس لو سعر السهم نزل ل + +288 +00:22:49,050 --> 00:22:57,140 +16 مين يقول لي إيش هيسوي المستثمر؟ هيدفع + +289 +00:22:57,140 --> 00:23:02,040 +عشرين هيدفع عشرين؟ هيدفع اثنين وعشرين؟ لأ مش + +290 +00:23:02,040 --> 00:23:06,960 +هيدفع .. هيدفع .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +291 +00:23:06,960 --> 00:23:07,300 +.. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. + +292 +00:23:07,300 --> 00:23:08,080 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +293 +00:23:08,080 --> 00:23:16,780 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +294 +00:23:16,780 --> 00:23:20,140 +.. لأ + +295 +00:23:22,460 --> 00:23:28,780 +أه بيكون كلفته عليه 18 شفتوا كيف صارت ال .. لأنه + +296 +00:23:28,780 --> 00:23:33,300 +السوق 16 فبقول لك ليش طبعا ليش هذه derivatives + +297 +00:23:33,300 --> 00:23:37,920 +احنا بنستخدمها هذه بنستخدمها بتقرأوا الكلام هذا من + +298 +00:23:37,920 --> 00:23:42,560 +ال chapter and you answer me in next meeting why + +299 +00:23:42,560 --> 00:23:48,420 +we use derivatives why investors using derivatives + +300 +00:23:48,420 --> 00:23:52,580 +موجودة عندكم الإجابة في الكتاب Okay so next meeting + +301 +00:23:52,580 --> 00:23:56,080 +إن شاء الله we will start our class by answering + +302 +00:23:56,080 --> 00:23:59,480 +this one okay any question? diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/a8rBMzpxgGc_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/a8rBMzpxgGc_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..3214b8d4addf6f62d60defd0e6633c298fca4cc1 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/a8rBMzpxgGc_raw.srt @@ -0,0 +1,1224 @@ +1 +00:00:21,800 --> 00:00:24,640 +المحاضرة اللي فاتت احنا حكينا عن ال syllabus تبع + +2 +00:00:24,640 --> 00:00:27,880 +المادة and what you have to do in the .. during + +3 +00:00:27,880 --> 00:00:33,160 +the class okay وشوفنا مع بعض how to download the + +4 +00:00:33,160 --> 00:00:36,860 +chapters and syllabus from the website طبعا هلأ + +5 +00:00:36,860 --> 00:00:41,460 +بدنا نحكي عن ال chapter one ال chapter one بيحكي + +6 +00:00:41,460 --> 00:00:43,380 +عن ال investment environment اللي هو بيئة + +7 +00:00:43,380 --> 00:00:47,500 +الاستثمار بيئة الاستثمار بتغطي ثلاث مواضيع أساسية + +8 +00:00:47,500 --> 00:00:51,420 +قبل ما ندخل بالتفاصيلالموضوع الأول what it means + +9 +00:00:51,420 --> 00:00:55,400 +investments which includes financial assets and + +10 +00:00:55,400 --> 00:00:58,320 +real assets بدنا نفرخ بين ال financial asset + +11 +00:00:58,320 --> 00:01:02,340 +الأصول المالية و الأصول الحقيقية the relationship + +12 +00:01:02,340 --> 00:01:06,880 +between financial markets and economic العلاقة بين + +13 +00:01:06,880 --> 00:01:08,780 +ال financial market و ال economics يعني علاقة + +14 +00:01:08,780 --> 00:01:12,360 +الأسواق المالية بالاقتصاد okay and we will talk + +15 +00:01:12,360 --> 00:01:14,680 +about the regulations of financial markets بعض ال + +16 +00:01:14,680 --> 00:01:18,110 +crisis and regulations of the financial marketsif + +17 +00:01:18,110 --> 00:01:21,110 +we are not follow up the regulations, what's + +18 +00:01:21,110 --> 00:01:22,550 +happening in the financial market؟ إذا احنا ما + +19 +00:01:22,550 --> 00:01:25,290 +بنطبخش تعليمات، شو ممكن يصير في ال financial + +20 +00:01:25,290 --> 00:01:28,290 +market؟ So first of all what it means investment؟ + +21 +00:01:28,290 --> 00:01:31,950 +ممكن تعليقنا إيش تفسيرك ل investment؟ هي current + +22 +00:01:31,950 --> 00:01:35,010 +commitment of money or other resources in this + +23 +00:01:35,010 --> 00:01:40,390 +vision of reaping .. reaping .. reaping .. okay .. + +24 +00:01:40,390 --> 00:01:46,300 +okay يعني إنه احنا التخلي عن المنفع حاليةللحصول + +25 +00:01:46,300 --> 00:01:51,180 +على عائد في المستقبل مثلا ان انا معايا فلوس الان + +26 +00:01:51,180 --> 00:01:55,960 +okay هدول الفلوس بروح أعملهم استثمار فانا اتخلت عن + +27 +00:01:55,960 --> 00:02:00,120 +منفعة استخدام الفلوس عشان يجيبولي عائد في المستقبل + +28 +00:02:00,120 --> 00:02:05,660 +يعني في المستقبل يجيبولي أرباح معينة أستثمرهم + +29 +00:02:05,660 --> 00:02:08,800 +بقطعة أرض وقطعة أرض في المستقبل أروح أبيع في + +30 +00:02:08,800 --> 00:02:11,820 +تجيبلي عائد فانا اتخلت عن منفعة حاليا لحصول على + +31 +00:02:11,820 --> 00:02:26,190 +منفعة مستقبل هي هذا المعنى الاستثمارOkay لأ + +32 +00:02:26,190 --> 00:02:29,850 +exactly + +33 +00:02:29,850 --> 00:02:34,070 +يعني مثل ما اتفضلتها لما احنا بنتخلع عن منفعة + +34 +00:02:34,070 --> 00:02:39,610 +حالية للحصول على منفعة أكبر في المستقبل إذا بنعدل + +35 +00:02:39,610 --> 00:02:44,030 +التعريف مش ف .. بس الحصول to get benefit from the + +36 +00:02:44,030 --> 00:02:49,340 +futurereturn is to maximize the future return ان + +37 +00:02:49,340 --> 00:02:52,920 +احنا نعظم المنفع المستقبلي يعني انا مثلا معايا الف + +38 +00:02:52,920 --> 00:02:58,120 +دولار اليوم اشتريت فيهم أصول هذه الأصول انا اتخلت + +39 +00:02:58,120 --> 00:03:02,540 +عن الف دولار ممكن اروح اكل فيهم ممكن اشتري شغلات + +40 +00:03:02,540 --> 00:03:05,600 +انا استخدمها لكن اتخلت فيهم عشان استثمر واشتريت + +41 +00:03:05,600 --> 00:03:10,380 +مثلا قطعة أرض او اشتريت أسهم في المستقبل هيجيني + +42 +00:03:10,380 --> 00:03:14,680 +عائد هذا العائد متوقع يكون أكبر من قيمة الف دولار + +43 +00:03:15,660 --> 00:03:21,680 +فهذا هو تعريف الاستثمار ال investment + +44 +00:03:21,680 --> 00:03:24,280 +environment ال environment هي البيئة المحيطة + +45 +00:03:24,280 --> 00:03:27,420 +بالاستثمار ال regulations الأدوات المالية اللي + +46 +00:03:27,420 --> 00:03:34,060 +احنا بنستثمر فيها التعليمات الحكومية اللي بتخلينا + +47 +00:03:34,060 --> 00:03:38,900 +نتنظم عملية الاستثمار أهم + +48 +00:03:38,900 --> 00:03:44,420 +عوامل في بيئة الاستثمار is to understandthe real + +49 +00:03:44,420 --> 00:03:48,500 +assets versus financial assets لازم نفهم شو الفرق + +50 +00:03:48,500 --> 00:03:51,900 +بين ال real assets و بين ال financial assets شو + +51 +00:03:51,900 --> 00:03:55,920 +معنى ال real assets أصول حقيقية أعطوني مثال عن + +52 +00:03:55,920 --> 00:04:03,640 +أصول حقيقية أرض مظبوط مباني machines equipments + +53 +00:04:03,640 --> 00:04:10,980 +ممكن إذا صنعناها صح؟البنات اللي وراها .. إيش + +54 +00:04:10,980 --> 00:04:17,620 +رأيكم؟ سيارات صح؟ أرضي + +55 +00:04:17,620 --> 00:04:26,600 +.. lands ممكن بس مش دقيق كتير okay ممكن مش دقيق + +56 +00:04:26,600 --> 00:04:32,430 +يعني هي أشياء it's helpال knowledge .. إيش ال + +57 +00:04:32,430 --> 00:04:37,910 +knowledge؟ كيف .. كيف ننقصها هذه ال knowledge؟ عن + +58 +00:04:37,910 --> 00:04:42,590 +مين موجودة ال knowledge هذه؟ ايوة بالظبط ال + +59 +00:04:42,590 --> 00:04:46,590 +knowledge .. ال knowledge is considered as a real + +60 +00:04:46,590 --> 00:04:51,130 +asset وهذه بيسموها بال .. بال .. بال accounting + +61 +00:04:51,130 --> 00:04:55,270 +intellectual property اسمها إيش؟ intellectual + +62 +00:04:55,270 --> 00:04:59,090 +property اللي هو حقوق الملكية و حقوق الفكريةهذه + +63 +00:04:59,090 --> 00:05:02,330 +بنعتبرها real assets sometimes .. sometimes you + +64 +00:05:02,330 --> 00:05:06,070 +get confused between what is real asset and what + +65 +00:05:06,070 --> 00:05:09,650 +is financial asset في بعض الناس بيفكروا ال + +66 +00:05:09,650 --> 00:05:12,570 +financial .. ال real asset هي ال .. is to be + +67 +00:05:12,570 --> 00:05:18,470 +touched اللي احنا بنلمسها لأ مش هذه تعريفها مش هي + +68 +00:05:18,470 --> 00:05:22,650 +يعني ممكن ال copyright تكون .. تكون real asset ال + +69 +00:05:22,650 --> 00:05:25,450 +knowledge ال intellectual property ك .. احنا ممكن + +70 +00:05:25,450 --> 00:05:32,420 +نمسك ال knowledgeوبالتالي هذه real assets ال real + +71 +00:05:32,420 --> 00:05:36,020 +assets زي ما احنا هنيجي نعرفها تتعمل ل productive + +72 +00:05:36,020 --> 00:05:40,540 +capacity and net income of the economy من هذه ال + +73 +00:05:40,540 --> 00:05:44,640 +real assets الدخل + +74 +00:05:44,640 --> 00:05:47,620 +الحقيقي للاقتصاد بييجي يعني الاقتصاد من وين + +75 +00:05:47,620 --> 00:05:51,780 +بيستفيد؟ بيستفيد من ال real assets وليس من ال + +76 +00:05:51,780 --> 00:05:56,730 +financial assetsالاقتصاد ليش؟ ال equipments ايش + +77 +00:05:56,730 --> 00:06:02,030 +بتطلعلي؟ ال equipments و ال machines بتطلعلي سلع و + +78 +00:06:02,030 --> 00:06:05,350 +بنروح هذه السلع بنبيعها و بالتالي بيصير عندى + +79 +00:06:05,350 --> 00:06:08,690 +income اذا هذه ال machines produce goods and + +80 +00:06:08,690 --> 00:06:12,590 +services then we sell these goods and services and + +81 +00:06:12,590 --> 00:06:16,630 +we get income so the economy is get benefited from + +82 +00:06:16,630 --> 00:06:21,630 +using the fixed asset يعني الاقتصاد بيستفيد من ال + +83 +00:06:21,630 --> 00:06:25,970 +fixed assetOkay؟ So the term is the productive + +84 +00:06:25,970 --> 00:06:30,350 +capacity ممكنية الإنتاج and net income of the + +85 +00:06:30,350 --> 00:06:35,510 +economy يعني بتعمل شغلتين تنتج وتجيب لإيراد هذا + +86 +00:06:35,510 --> 00:06:38,310 +بالنسبة لإيش ال real asset إذا إحنا طبقنا الكلام + +87 +00:06:38,310 --> 00:06:41,650 +هذا بنقدر نقول هذا real asset أو not real asset + +88 +00:06:41,650 --> 00:06:48,110 +واضح الكلام هذا؟ إذا واضح إنه real asset إذا ال + +89 +00:06:48,110 --> 00:06:51,110 +real asset مش بس machines مش بس equipments ممكن + +90 +00:06:51,110 --> 00:06:52,710 +تكون شغلات تانية هنسأل فيها كم شوية + +91 +00:06:56,410 --> 00:07:00,090 +أمثلة اللي انتوا حاكيتوها lands, buildings, + +92 +00:07:00,210 --> 00:07:02,270 +machines, knowledge used to produce goods and + +93 +00:07:02,270 --> 00:07:06,950 +services وفي شغلات تانية احنا we leave it just to + +94 +00:07:06,950 --> 00:07:09,930 +examine your understanding يعني في شغلات تانية + +95 +00:07:09,930 --> 00:07:15,590 +هنشوف activity فيها تتعرف على new real assets مش + +96 +00:07:15,590 --> 00:07:18,830 +واضحة علنا واحنا هنوضحها طب نشوف ال financial + +97 +00:07:18,830 --> 00:07:22,230 +assets ال financial assets a claims on real assets + +98 +00:07:22,230 --> 00:07:29,680 +في حد بيعرف what it means this؟البنات الجانب هذا + +99 +00:07:29,680 --> 00:07:35,140 +بتشتغلوا معانا اه؟ شوفوا اذا اهمية بنات اهميتهم ان + +100 +00:07:35,140 --> 00:07:40,680 +انتوا تقرأوا قبل ما تيجوا عشان انا بعرف وين ال .. + +101 +00:07:40,680 --> 00:07:42,920 +وين ال .. ال weaknesses point وين ال strength + +102 +00:07:42,920 --> 00:07:47,760 +point عندكم وبتعلم ممكن نسهل عملية الشرح اه؟ + +103 +00:07:52,080 --> 00:07:57,100 +من وين أجدت هذه؟ من النبع من الأصول الحقيقية + +104 +00:07:57,100 --> 00:08:02,020 +بالظبط صح يعني ال financial assets are claims on + +105 +00:08:02,020 --> 00:08:06,360 +real assets يعني هي التزامات ناتجة عن الأصول + +106 +00:08:06,360 --> 00:08:10,740 +الحقيقية يعني مثلا في حد بيقدر يعطيني مثال كيف how + +107 +00:08:10,740 --> 00:08:15,400 +the how the financial how the real assets generate + +108 +00:08:15,400 --> 00:08:19,480 +financial assets مش هيك claims on real assets it + +109 +00:08:19,480 --> 00:08:23,060 +meansthe real assets generate financial assets + +110 +00:08:23,060 --> 00:08:27,200 +يعني مين أبو ال financial assets؟ هي ال real + +111 +00:08:27,200 --> 00:08:31,740 +assets فإذن the real assets the .. the .. the + +112 +00:08:31,740 --> 00:08:35,180 +financial asset is not coming from nothing it is + +113 +00:08:35,180 --> 00:08:39,400 +not coming from itself ما إجتش من نفسها it comes + +114 +00:08:39,400 --> 00:08:43,960 +from the real assets إجت من ال real assets هعطوني + +115 +00:08:43,960 --> 00:08:48,830 +مثال على الكلام هذا اتفضليطب نصنعها نستخدم في + +116 +00:08:48,830 --> 00:08:51,730 +إنتاج .. ننتج .. ننتج سلاح لما نبيعها نحصل على + +117 +00:08:51,730 --> 00:08:55,290 +الأموال طيب وين ال financial asset اللي اندوالها + +118 +00:08:55,290 --> 00:09:02,390 +ده تجديد؟ سيارات؟ لأ مش كتير ال example انت بدأت + +119 +00:09:02,390 --> 00:09:08,230 +صح بس بالأخير ما .. وين ال financial asset؟ how .. + +120 +00:09:08,230 --> 00:09:12,290 +how the real assets generate financial assets؟ + +121 +00:09:12,290 --> 00:09:14,550 +اتفضلي الأموال اللي نبتشت في السلاح + +122 +00:09:19,040 --> 00:09:23,460 +Okay تقريبا يمكننا نعطي مثال زي ما انت حكيت المثال + +123 +00:09:23,460 --> 00:09:29,060 +ايش اسمك اسمها اسمها أعطتنا مثال مثلا اشترينا + +124 +00:09:29,060 --> 00:09:36,940 +machines machine آلة هاي الآلة اشتريناها okay + +125 +00:09:36,940 --> 00:09:44,240 +هذه ال machine احنا أمامنا خيارين يا أما ندفع cash + +126 +00:09:45,580 --> 00:09:54,460 +يا أما ناخد قرض صح؟ machine نشتري آلة يا أما معانا + +127 +00:09:54,460 --> 00:09:57,920 +فلوس بجيبتنا بنشتري ال machine يا أما ماعناش فلوس + +128 +00:09:57,920 --> 00:10:00,180 +بنروح على البنك الإسلامي و لا بنروح على البنوك هاي + +129 +00:10:00,180 --> 00:10:05,420 +و بنروح ناخد قرض أو مرابحة أو .. هذا القرض هو real + +130 +00:10:05,420 --> 00:10:09,740 +asset و لا financial asset؟ من وين إجا؟ إجا لأنه + +131 +00:10:09,740 --> 00:10:13,540 +اشترينا machine إذا because of using machines + +132 +00:10:13,540 --> 00:10:17,650 +because of buying machinesthe machines generate + +133 +00:10:17,650 --> 00:10:23,230 +loans هى طلعتلى ال loans وإلا لو احنا مااشترناش + +134 +00:10:23,230 --> 00:10:29,150 +machines ليش بيلزم القرض؟ اذا الماكينة هذه لما + +135 +00:10:29,150 --> 00:10:35,310 +اشترناها أخدنا قرض عشان نشريها هذا القرض هو عبارة + +136 +00:10:35,310 --> 00:10:40,010 +عن financial assets عبارة عن أصول مالية طيب طريقة + +137 +00:10:40,010 --> 00:10:52,650 +تانية فضله اه خليني أسمعهاطبعا .. بالظبط .. + +138 +00:10:52,650 --> 00:11:01,240 +صح .. تاخد قرد او تطرح حياتهم .. بالظبط ..buying + +139 +00:11:01,240 --> 00:11:06,260 +the land or building or starting of a project need + +140 +00:11:06,260 --> 00:11:11,740 +to issue shares or bonds or loans فلأن أن أنت بدك + +141 +00:11:11,740 --> 00:11:15,640 +تشتري الأرض و تعمل مشروع فبدك تضطري تطرحي أسهم بدك + +142 +00:11:15,640 --> 00:11:19,540 +تضطري تطرحي سندات أو تاخدي قرض فهدول اللي عملوه ي + +143 +00:11:19,540 --> 00:11:22,580 +generate لإيش؟ ل financial assets طب نيجي نسأل + +144 +00:11:22,580 --> 00:11:25,980 +السؤال ال income الحقيقي بيجي من وين؟ من ال real + +145 +00:11:25,980 --> 00:11:29,000 +assets ولا من ال financial assets؟ من ال real + +146 +00:11:29,000 --> 00:11:34,450 +assetsإذا الحقيقة هيجي من وين؟ أنا أصلا كانت Indie + +147 +00:11:34,450 --> 00:11:38,610 +Art بالظبط من ال real asset لأن ال real asset انت + +148 +00:11:38,610 --> 00:11:41,530 +هتعمل المصنع و ال machines producing goods and + +149 +00:11:41,530 --> 00:11:45,230 +services و ال goods and services will be sold in + +150 +00:11:45,230 --> 00:11:48,950 +the markets so it generates income and the income + +151 +00:11:48,950 --> 00:11:53,650 +recover ال loans شفتوا كيف ال cycle هتمشي؟ يعني + +152 +00:11:53,650 --> 00:11:56,970 +هذه ال machines اللي احنا اشتريناهاهتعمل producing + +153 +00:11:56,970 --> 00:12:00,530 +لإيش؟ ل goods and services ال goods and services + +154 +00:12:00,530 --> 00:12:04,410 +نعملها صالب في السوق بتعملني income ال income + +155 +00:12:04,410 --> 00:12:09,990 +بيسكبلي ال loans who generates the income؟ the + +156 +00:12:09,990 --> 00:12:19,010 +real assets فضل claims on real + +157 +00:12:19,010 --> 00:12:24,020 +assets التزامات على الأصول الثابتةمثلها ده اه انا + +158 +00:12:24,020 --> 00:12:28,380 +برأي انه ال real assets claim on financial يعني ال + +159 +00:12:28,380 --> 00:12:31,840 +real asset هي اللي بتسدد ال .. اه لإنه جد لإن ال + +160 +00:12:31,840 --> 00:12:34,620 +financial احنا أخدنا قرض و بتفتحلي القرض هو + +161 +00:12:34,620 --> 00:12:38,400 +financial asset و شرينا منك يعني القرض أعلى، + +162 +00:12:38,400 --> 00:12:40,420 +الأعلى هي ال real asset دي بقى و مين اللي بيبقى + +163 +00:12:40,420 --> 00:12:44,440 +عالمي okay هلا بنيجي ال .. ال machines هي اللي + +164 +00:12:44,440 --> 00:12:48,640 +producing the goods and services ولا القرض طب + +165 +00:12:48,640 --> 00:12:52,480 +خلينا ناخد .. بدناش machinesو نحكي للقارد please + +166 +00:12:52,480 --> 00:12:58,020 +generate goods and services we can do it we cannot + +167 +00:12:58,020 --> 00:13:03,260 +do it because loans cannot create income ال loans + +168 +00:13:03,260 --> 00:13:08,540 +مابيعطونيش income a real income هاي بيعطي interest + +169 +00:13:08,540 --> 00:13:15,940 +interest as a compensation of the utility هو نتيجة + +170 +00:13:15,940 --> 00:13:25,040 +عنتعويض للمنفع المستقبلية و ليس بسبب استخدامنا لل + +171 +00:13:25,040 --> 00:13:28,940 +machines طيب إذا ال machines اللي اشتريناها هي + +172 +00:13:28,940 --> 00:13:32,340 +اللي هتعملني goods and services و بعدين احنا هنغطي + +173 +00:13:32,340 --> 00:13:37,040 +ال loans و and the cycle is going in this way لأن + +174 +00:13:37,040 --> 00:13:42,460 +احنا لو حاجت لأن مش عايشة أكتر .. بالظبط .. that's + +175 +00:13:42,460 --> 00:13:46,480 +itيعني both of you are right يعني انتوا التنين + +176 +00:13:46,480 --> 00:13:51,860 +صحيح انه ال .. the .. the fixed assets generate a + +177 +00:13:51,860 --> 00:13:56,620 +real .. a real income بس هاي ال loans is a + +178 +00:13:56,620 --> 00:14:00,160 +compensation لأن احنا هندفع بالloan شغلتان او في + +179 +00:14:00,160 --> 00:14:04,420 +المرابحة هندفع شغلتان هندفع اللي هو ال .. ال .. + +180 +00:14:04,420 --> 00:14:08,360 +the value of .. of .. of .. of loan plus the + +181 +00:14:08,360 --> 00:14:13,420 +interestال interest why the interest is the + +182 +00:14:13,420 --> 00:14:16,640 +compensation for investors احنا بنعوضهم لأنهم + +183 +00:14:16,640 --> 00:14:21,640 +اتنازلوا عن المنفع الحالية لمنطقة مستخبرية بس بس + +184 +00:14:21,640 --> 00:14:26,440 +ال machines هي الأساس اللي هتعطيني ال generate the + +185 +00:14:26,440 --> 00:14:33,360 +income and if this if the machine stop working it + +186 +00:14:33,360 --> 00:14:37,730 +means we cannot pay back the loansنقدرش احنا + +187 +00:14:37,730 --> 00:14:41,290 +هنسيبنا ال loans اذا مين بيعمل generation لل + +188 +00:14:41,290 --> 00:14:48,610 +income؟ if the real assets stop working مش + +189 +00:14:48,610 --> 00:14:52,650 +هنقدر نعمل و زي ما صار بال mortgages مش هندخل فيها + +190 +00:14:52,650 --> 00:14:58,750 +لما نيجي نحكي في الموضوع تبعها okay؟ + +191 +00:14:58,750 --> 00:15:00,730 +في حد عنده سؤال what is the difference between + +192 +00:15:00,730 --> 00:15:03,810 +real assets and financial assets؟ exam is of + +193 +00:15:03,810 --> 00:15:07,100 +financial assetsأمثلة على ال financial assets + +194 +00:15:07,100 --> 00:15:16,060 +bonds loans stocks أسهم ايش فيه كمان treasure + +195 +00:15:16,060 --> 00:15:20,200 +bills CDs we have thousands of financial assets + +196 +00:15:20,200 --> 00:15:24,060 +هيكون في عندي chapter كامل بس بيعمللي listing لهذه + +197 +00:15:24,060 --> 00:15:29,060 +ال financial assets okay نيجي على ال financial + +198 +00:15:29,060 --> 00:15:33,440 +assets three types there are three main types of + +199 +00:15:33,440 --> 00:15:36,900 +financial assetsثلاث أنواع أساسية لل financial + +200 +00:15:36,900 --> 00:15:43,660 +assets okay fixed income or debts في financial + +201 +00:15:43,660 --> 00:15:54,060 +asset بتعطيني fixed income ثابت عائد ثابت طبعا حد + +202 +00:15:54,060 --> 00:15:58,500 +يعطيني مثال على financial asset بتعطيني عائد ثابت + +203 +00:15:58,500 --> 00:16:08,840 +زي إيش السندات صح القروض صحالأسهم ممتازة صح، إذا + +204 +00:16:08,840 --> 00:16:12,820 +هاي عندنا ال bonds, preferred stocks و ال loans, + +205 +00:16:13,460 --> 00:16:18,040 +treasury bills, CDs كلهم هدول بيعطوني ايه؟ بيعطوني + +206 +00:16:18,040 --> 00:16:24,240 +fixed income لكن في مشاكل إن احنا نحصل على fixed + +207 +00:16:24,240 --> 00:16:28,260 +income okay + +208 +00:16:28,260 --> 00:16:33,520 +هنيجي نحكي في الموضوعالنوع التاني ال common stocks + +209 +00:16:33,520 --> 00:16:37,700 +common stock or equity ال common stock or equity + +210 +00:16:37,700 --> 00:16:44,620 +اللي هو الأسهم العادية أو حقوق الملكية يعني + +211 +00:16:44,620 --> 00:16:46,780 +في ناس بيسموها common stock و في ناس بيسموها + +212 +00:16:46,780 --> 00:16:51,730 +equityلأنه ممكن ندخل ال dividends عارفين الأسهم + +213 +00:16:51,730 --> 00:16:54,770 +العادية طبعا بال financial management أخدتوا انتوا + +214 +00:16:54,770 --> 00:16:57,030 +what it means common stock what is the difference + +215 +00:16:57,030 --> 00:16:59,290 +between common stock and preferred stocks الفروقات + +216 +00:16:59,290 --> 00:17:01,830 +بين ال common stock و ال preferred stocks واضحة + +217 +00:17:01,830 --> 00:17:08,750 +عندكم؟ okay derivative securities هاد الموضوع شوية + +218 +00:17:08,750 --> 00:17:12,090 +في حد سمع بال derivative securities قبل هك؟ + +219 +00:17:15,960 --> 00:17:18,820 +الأوراق المالية هي ال high financial asset الأوراق + +220 +00:17:18,820 --> 00:17:24,100 +المالية derivatives مشتقات اسمها مشتقات what is + +221 +00:17:24,100 --> 00:17:27,420 +the story of derivatives؟ شو هي ال derivatives؟ + +222 +00:17:27,420 --> 00:17:30,740 +and from where the derivatives come from؟ من وين + +223 +00:17:30,740 --> 00:17:34,800 +إجت ال derivatives؟ + +224 +00:17:34,800 --> 00:17:43,840 +بسيطة احنا خلينا نبدأ ال story من بدايتهاwe agree + +225 +00:17:43,840 --> 00:17:50,060 +that real assets generate financial assets، مظبوط؟ + +226 +00:17:50,060 --> 00:17:55,240 +اذا real assets generate + +227 +00:17:55,240 --> 00:17:58,480 +financial assets، abbreviation for financial + +228 +00:17:58,480 --> 00:18:05,680 +assets okay financial assets generate derivatives + +229 +00:18:05,680 --> 00:18:10,280 +what + +230 +00:18:10,280 --> 00:18:16,070 +it means derivativesمشتقات it means derivatives is + +231 +00:18:16,070 --> 00:18:21,130 +derived from the prices of financial assets يعني + +232 +00:18:21,130 --> 00:18:23,650 +ال derivatives هي مشتقة من أسعار ال financial + +233 +00:18:23,650 --> 00:18:31,410 +assets so the investors and derivatives drive + +234 +00:18:31,410 --> 00:18:35,950 +transactions or drive investments on the prices of + +235 +00:18:35,950 --> 00:18:39,950 +financial assets how it comes؟ كيف هذا الكلام + +236 +00:18:39,950 --> 00:18:47,170 +بيصير؟مثال بسيط derivatives includes three types + +237 +00:18:47,170 --> 00:18:52,570 +option future + +238 +00:18:52,570 --> 00:19:04,330 +and swap okay let's take example of the option and + +239 +00:19:04,330 --> 00:19:06,850 +how the option is derived from the financial + +240 +00:19:06,850 --> 00:19:13,010 +assetsas we agree before the common stock is one + +241 +00:19:13,010 --> 00:19:14,930 +of the financial assets واحدة من ال financial + +242 +00:19:14,930 --> 00:19:20,430 +assets okay اذا هاي stock هاي financial assets هلا + +243 +00:19:20,430 --> 00:19:25,690 +بنعمل drive ل financial ل derivatives ناخد ال + +244 +00:19:25,690 --> 00:19:31,170 +option سعر ال stock في السوق نفترض عشرين دولار + +245 +00:19:31,170 --> 00:19:36,100 +سعره في السوق عشرين دولارإذا نعيد تعريف ال + +246 +00:19:36,100 --> 00:19:39,480 +derivatives is derived from the prices of the + +247 +00:19:39,480 --> 00:19:43,940 +financial assets بس احنا موضوعنا بس ل prices بيجي + +248 +00:19:43,940 --> 00:19:48,960 +واحد من المستثمرين بيحكي انه انا بدي أشري السهم + +249 +00:19:48,960 --> 00:19:55,300 +هذا بعد تلت شهور بدي أشري بعد تلت شهور طيب بعد تلت + +250 +00:19:55,300 --> 00:20:02,980 +شهور احتمال السعر يطلع واحتمال ينزل فعشان + +251 +00:20:02,980 --> 00:20:06,540 +هومايصيرش عنده مشكلة في الاستثمار بروح على + +252 +00:20:06,540 --> 00:20:10,260 +derivatives derivatives derivatives بتسهل له عملية + +253 +00:20:10,260 --> 00:20:15,460 +fixing the price بتعمله ايش fixing the price تثبيت + +254 +00:20:15,460 --> 00:20:21,340 +السعر تثبيت السعر مقابل premium مقابل ايش premium + +255 +00:20:21,340 --> 00:20:25,060 +يعني علاوة بروح بيحكوا لهم okay السعر الآن عشرين + +256 +00:20:25,060 --> 00:20:29,100 +دولار انا بدي اثبت السعر لانه بدي اشري هذا السهم + +257 +00:20:29,100 --> 00:20:34,380 +بعد تلات شهورفبقولوا له okay بتدفع two dollar هدول + +258 +00:20:34,380 --> 00:20:38,600 +ال premium هو هيدفع فقط two dollar مش هيدفع عشرين + +259 +00:20:38,600 --> 00:20:45,720 +والعشرين مدى هيدفعهم بعد تلات شغل مادفع + +260 +00:20:45,720 --> 00:20:51,420 +عشان ساعتين وعشرين دفع كام بالظبط كلامك صح طيب هلأ + +261 +00:20:51,420 --> 00:20:55,880 +ناخد احتمالين ناخد two option this is why this is + +262 +00:20:55,880 --> 00:21:00,210 +optionالفرص الأولى هو أن السعر يزال يزال يزال يزال + +263 +00:21:00,210 --> 00:21:03,030 +يزال يزال يزال يزال يزال يزال يزال يزال يزال يزال + +264 +00:21:03,030 --> 00:21:07,790 +يزال يزال يزال يزال يزال يزال يزال يزال يزل يزل + +265 +00:21:07,790 --> 00:21:13,990 +يزل يزل يزل يزل يزل يزل + +266 +00:21:13,990 --> 00:21:14,790 +يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل + +267 +00:21:14,790 --> 00:21:14,790 +يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل + +268 +00:21:14,790 --> 00:21:14,850 +يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل يزل + +269 +00:21:14,850 --> 00:21:23,590 +يزل يزل يزل يزل يز + +270 +00:21:23,680 --> 00:21:28,160 +and he or she saw the price twenty five شو راح + +271 +00:21:28,160 --> 00:21:34,040 +يسوي ال investors في الحالة الأولى هو ثبته على + +272 +00:21:34,040 --> 00:21:37,880 +عشرين هيدفع ال premium two دولار وسعره في السوق + +273 +00:21:37,880 --> 00:21:40,880 +خمسة و عشرين دولار شو راح يسوي ال investors هيدفع + +274 +00:21:40,880 --> 00:21:44,300 +عشرين و two premium هدفع اتنين و عشرين المستثمر + +275 +00:21:44,300 --> 00:21:49,980 +كام ربح تلاتة دولار في ال case الأولى three + +276 +00:21:49,980 --> 00:21:50,400 +dollars + +277 +00:21:53,040 --> 00:21:57,640 +أه هلا احنا في عندنا ثبتنا السعر عشرين في premium + +278 +00:21:57,640 --> 00:22:00,880 +العربون احنا بالعربي بنسميها عربون صح؟ يعني انت + +279 +00:22:00,880 --> 00:22:03,960 +بدك تشروح تشتري بيت و ماعاكيش فلوس فبتقول رجال خد + +280 +00:22:03,960 --> 00:22:07,080 +هاي عربون و انا بعد تلات شهور هابعتلك الفلوس اذا + +281 +00:22:07,080 --> 00:22:12,620 +ماجبت ال cash الفلوس بروح علياش العربون فهما كيف + +282 +00:22:12,620 --> 00:22:17,740 +يعني هاي مثال بالان بالبلد طيب هلا نيجي ال .. + +283 +00:22:17,740 --> 00:22:23,850 +السعر خمسة و عشرين دولارفى ال $2 هدفعه من عربون و + +284 +00:22:23,850 --> 00:22:29,190 +$20 فصاروا 22 المفروض بدون ادفع في السوق سعر السهم + +285 +00:22:29,190 --> 00:22:34,570 +او سعر السهم 25$ فهم ثبته يعني ثبت سعره خلاص بدفع + +286 +00:22:34,570 --> 00:22:38,270 +ال 20 و ال $2 premium هي 22 لو حابب ببيعه في نفس + +287 +00:22:38,270 --> 00:22:44,030 +اللحظة بعمل 3$ في كل سهم واضح طيب هلأ ناخد ال + +288 +00:22:44,030 --> 00:22:49,050 +opposite ناخد العكس ناخد العكس لو سعر السهم نزل ل + +289 +00:22:49,050 --> 00:22:57,140 +16مين يقول لي إيش هيسوي المستثمر؟ هيدفع + +290 +00:22:57,140 --> 00:23:02,040 +عشرين هيدفع عشرين؟ هيدفع اتنين و عشرين؟ لأ مش + +291 +00:23:02,040 --> 00:23:06,960 +هيدفع .. هيدفع .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +292 +00:23:06,960 --> 00:23:06,960 +.. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. + +293 +00:23:06,960 --> 00:23:06,960 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +294 +00:23:06,960 --> 00:23:07,300 +.. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. + +295 +00:23:07,300 --> 00:23:08,080 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +296 +00:23:08,080 --> 00:23:08,080 +.. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. + +297 +00:23:08,080 --> 00:23:16,780 +لأ .. لأ .. لأ .. لأ .. لأ .. لأ .. لأ + +298 +00:23:16,780 --> 00:23:20,140 +.. لأ + +299 +00:23:22,460 --> 00:23:28,780 +أه بيكون كلفته عليه 18 شفتوا كيف صارت ال .. لأنه + +300 +00:23:28,780 --> 00:23:33,300 +السوق 16 فبقولك ليش انا طبعا ليش هذه derivatives + +301 +00:23:33,300 --> 00:23:37,920 +احنا بنستخدمها هذه بنستخدمها بتقرأوا الكلام هذا من + +302 +00:23:37,920 --> 00:23:42,560 +ال chapter and you answer me in next meeting why + +303 +00:23:42,560 --> 00:23:48,420 +we use derivatives why investors using derivatives + +304 +00:23:48,420 --> 00:23:52,580 +موجودة عندكم الإجابة في الكتابOkay so next meeting + +305 +00:23:52,580 --> 00:23:56,080 +inshallah we will start our class by answering + +306 +00:23:56,080 --> 00:23:59,480 +this one okay any question? + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/g6Dw4Dppwrs_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/g6Dw4Dppwrs_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..0fb1ab255a1d20afc3046af927f511658be8f142 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/g6Dw4Dppwrs_raw.srt @@ -0,0 +1,1540 @@ +1 +00:00:20,940 --> 00:00:25,580 +بسم الله الرحمن الرحيم في ال .. في المحاضرات + +2 +00:00:25,580 --> 00:00:29,300 +السابقة كنا نحكي عن ال .. ال efficiency markets و + +3 +00:00:29,300 --> 00:00:35,320 +market efficiency event studies اللي هو دراسة .. + +4 +00:00:35,320 --> 00:00:38,500 +أحداث بتصير في .. في تاريخ المنشئات بيسموها event + +5 +00:00:38,500 --> 00:00:43,640 +studies to examine the .. whether the market is + +6 +00:00:43,640 --> 00:00:49,140 +efficient or notthe main focus on the event + +7 +00:00:49,140 --> 00:00:52,540 +studies عشان احنا نعرف انه هل السوق المالي + +8 +00:00:52,540 --> 00:00:56,100 +efficient ولا مش efficient or efficient or + +9 +00:00:56,100 --> 00:01:00,420 +inefficient most of the researchers using event + +10 +00:01:00,420 --> 00:01:05,560 +studies اغلب الباحثين بيعملوا .. براكزوا على event + +11 +00:01:05,560 --> 00:01:10,340 +studies okay what it means event studies ايش معناه + +12 +00:01:10,340 --> 00:01:14,540 +event studies what it means eventحدث اعطوني مثال + +13 +00:01:14,540 --> 00:01:17,500 +give me example about a particular event in a + +14 +00:01:17,500 --> 00:01:21,800 +company اعطوني حدث معين في شركة صار في شركة + +15 +00:01:21,800 --> 00:01:26,660 +مابدناش يكون في .. في .. في اقتصاد يعني a + +16 +00:01:26,660 --> 00:01:30,120 +particular event ايش فيه احداث في الشركات؟ اللي هو + +17 +00:01:30,120 --> 00:01:34,960 +اللي يجيه الشركة اللي بتاعتها okay خلي اشوف اكتر + +18 +00:01:34,960 --> 00:01:39,060 +دقة من ال event ده ايش فيه event فعلا ايش فيه + +19 +00:01:39,060 --> 00:01:40,940 +احداث بتسير في حياة الشركات؟ + +20 +00:01:44,510 --> 00:01:48,570 +أه ربح و خسارة اللي هو paying dividends paying + +21 +00:01:48,570 --> 00:01:53,690 +dividends مظبوط توزيع الأرباح okay paying out + +22 +00:01:53,690 --> 00:01:57,570 +paying out paying out اللي هى بيسموها ال dividends + +23 +00:01:57,570 --> 00:01:59,790 +التوزيعات + +24 +00:02:01,500 --> 00:02:06,620 +Paying out or dividends هذا حدث بنشوف what is the + +25 +00:02:06,620 --> 00:02:10,140 +impact of dividends on the stock price performance + +26 +00:02:10,140 --> 00:02:12,480 +بنشوف أثر ال dividends على ال stock price + +27 +00:02:12,480 --> 00:02:17,800 +performance طيب إيش في event غير هيك ماسمعتوه + +28 +00:02:17,800 --> 00:02:24,980 +بتسمعوش أخبار مثلا مثلا new invention or new + +29 +00:02:24,980 --> 00:02:29,960 +copyright مثلا new production line خطوط إنتاج + +30 +00:02:29,960 --> 00:02:31,240 +جديدة new production line + +31 +00:02:34,240 --> 00:02:40,180 +or release new products or launch new products + +32 +00:02:40,180 --> 00:02:46,520 +يعني زي مثلا launch new products for instance when + +33 +00:02:46,520 --> 00:02:51,580 +apple launch iphone 4 or iphone 5 so what is the + +34 +00:02:51,580 --> 00:02:55,080 +impact of iphone 5 on the stock price performance + +35 +00:02:56,090 --> 00:02:59,190 +تمام؟ إيش فيه كمان events؟ ممكن تقول .. company + +36 +00:02:59,190 --> 00:03:03,030 +share اسمه company .. okay this is like merging + +37 +00:03:03,030 --> 00:03:07,590 +okay or taking over يعني يصير في merging between + +38 +00:03:07,590 --> 00:03:11,250 +.. or taking over this is .. this is also event + +39 +00:03:11,250 --> 00:03:20,310 +okay emerge and take over take over يعني معناه + +40 +00:03:20,310 --> 00:03:24,540 +سيطرةيعني يا أما damage يا أما سيطرة what else؟ + +41 +00:03:24,540 --> 00:03:35,860 +يالا فاكرولي event event studies okay مستمر okay + +42 +00:03:35,860 --> 00:03:41,820 +so investing in new .. a new section or a new + +43 +00:03:41,820 --> 00:03:46,200 +product production line or a new areas or a new + +44 +00:03:46,200 --> 00:03:49,380 +geographic areas for instance investing in Ghana + +45 +00:03:49,380 --> 00:03:55,930 +in South Africa okayevent studies may be scandals + +46 +00:03:55,930 --> 00:04:00,970 +بعد الفضايح بتصير في تاريخ الشركات for instance + +47 +00:04:00,970 --> 00:04:05,090 +Enron a scandal زي ال leak اللي صار مع ال بي بي + +48 +00:04:05,090 --> 00:04:11,110 +the leak of petrol from the BB British Petroleum + +49 +00:04:11,110 --> 00:04:18,990 +سمعتوا عن الفضيحة قبل سنتين اظن تسربوا بالنفطتسرب + +50 +00:04:18,990 --> 00:04:24,390 +النفط في أحد تجمع النفط في أظن المحيط الأطلانتي + +51 +00:04:24,390 --> 00:04:30,890 +وخسرت الشركة billions of dollar مليارات الدولارات + +52 +00:04:30,890 --> 00:04:35,090 +حتى يسرطلوا على بُقعة النفط فهذا is event هذا + +53 +00:04:35,090 --> 00:04:40,370 +event حدث في تاريخ الشركة طيب okay هلا ال event + +54 +00:04:40,370 --> 00:04:44,540 +studies release new informationيعني مثلا خلينا + +55 +00:04:44,540 --> 00:04:48,100 +نحكي dividends, paying out dividends when + +56 +00:04:48,100 --> 00:04:51,660 +companies decide to paying out, paying out it is + +57 +00:04:51,660 --> 00:04:55,740 +releasing new information يعني هي تطلع معلومات + +58 +00:04:55,740 --> 00:04:59,540 +جديدة so how the financial market digest this + +59 +00:04:59,540 --> 00:05:01,380 +information or how the financial market + +60 +00:05:01,380 --> 00:05:04,260 +incorporates this new information into the price + +61 +00:05:04,260 --> 00:05:06,880 +because this is .. this is .. this is a new + +62 +00:05:06,880 --> 00:05:10,390 +information paying out dividendsهذا يعني كيف + +63 +00:05:10,390 --> 00:05:15,190 +يتشارك السعر مع المعلومات إذا كان السعر يتشارك هذه + +64 +00:05:15,190 --> 00:05:22,610 +المعلومات بسرعة و بسهولة أو خلال وقت محدد، فهذا + +65 +00:05:22,610 --> 00:05:27,570 +يعني أن هذا مجتمع مفيد أو هذا المجتمع المفيد دعونا + +66 +00:05:27,570 --> 00:05:33,930 +نعتبر هذا الحالة إذا + +67 +00:05:33,930 --> 00:05:43,300 +كان لدينا معلومات جديدةlook at this chart here if + +68 +00:05:43,300 --> 00:05:46,080 +we have a new information and this information + +69 +00:05:46,080 --> 00:05:51,240 +will be released in day zero day zero it means the + +70 +00:05:51,240 --> 00:05:54,500 +day of the information or the day of the new + +71 +00:05:54,500 --> 00:06:02,820 +information okay this is a new information this + +72 +00:06:02,820 --> 00:06:07,810 +new information is due in day zero في يومSo to + +73 +00:06:07,810 --> 00:06:11,950 +observe the changes or how the price reflect this + +74 +00:06:11,950 --> 00:06:15,890 +new information we have to observe the stock price + +75 +00:06:15,890 --> 00:06:21,990 +before and the stock price after عشان احنا نعرف + +76 +00:06:21,990 --> 00:06:25,830 +انه هل ال new information أثرت على ال stock price + +77 +00:06:25,830 --> 00:06:29,570 +performance او أثرت على ال rate of return او أثرت + +78 +00:06:29,570 --> 00:06:36,870 +على ال R rate of returnلازم ناخد قبل ما صار الحدث + +79 +00:06:36,870 --> 00:06:42,470 +و بعد ما صار الحدث okay so we can take + +80 +00:06:42,470 --> 00:06:49,930 +observations pre the event and + +81 +00:06:49,930 --> 00:06:56,610 +post the event then we estimate R the rate of + +82 +00:06:56,610 --> 00:07:05,450 +return we estimate R at pre and R at postإذا R في + +83 +00:07:05,450 --> 00:07:10,570 +الوصف أكبر من R في الأمام، فهذا يعني أن هناك تأثير + +84 +00:07:10,570 --> 00:07:15,530 +على المعلومات الجديدة على الـ Return. لذلك، هنا + +85 +00:07:15,530 --> 00:07:21,310 +نخلق Return غير عادل، لأن R في الوصف أكبر من R في + +86 +00:07:21,310 --> 00:07:26,850 +الأمام، وهو ما يخلق Return غير عادل. إذا كان لدينا + +87 +00:07:26,850 --> 00:07:31,610 +Return غير عادل، فهو Positive، لأن ر بوست أكبر من + +88 +00:07:31,610 --> 00:07:35,460 +ر بي،So if we have positive abnormal return it + +89 +00:07:35,460 --> 00:07:39,680 +means the new information released to the market + +90 +00:07:39,680 --> 00:07:44,240 +has a positive impact on the rate of return يعني + +91 +00:07:44,240 --> 00:07:51,540 +إذا شفنا إحنا العائدبعد الحدث أعلى من العائد قبل + +92 +00:07:51,540 --> 00:07:55,680 +الحدث ما كان فيه abnormal return عائد غير طبيعي طب + +93 +00:07:55,680 --> 00:07:58,260 +العائد الغير طبيعي ليش صار because of the new + +94 +00:07:58,260 --> 00:08:01,140 +information لأن ال new information هي اللي عملت ال + +95 +00:08:01,140 --> 00:08:04,280 +abnormal rate of return يعني هذه ال new + +96 +00:08:04,280 --> 00:08:11,800 +information make the abnormal rate of return okay + +97 +00:08:11,800 --> 00:08:20,230 +if R at pre if R at pre equalare at post so there + +98 +00:08:20,230 --> 00:08:23,070 +is no impact of the events on the abnormality of + +99 +00:08:23,070 --> 00:08:27,510 +return إذا كانت ال are at pre زي ال are at post + +100 +00:08:27,510 --> 00:08:34,990 +مافيش دور للمعلومات if the opposite if are at post + +101 +00:08:36,900 --> 00:08:41,400 +أو إذا R at pre أكبر من R at post، يعني أن + +102 +00:08:41,400 --> 00:08:44,920 +المعلومات لديها تأثير إيقافي أو إيقافي إيقافي + +103 +00:08:44,920 --> 00:08:48,480 +إيقافي، لديها تأثير إيقافي على تجارب الأسعار، + +104 +00:08:48,480 --> 00:08:49,800 +تجارب الأسعار، تجارب الأسعار، تجارب الأسعار، تجارب + +105 +00:08:49,800 --> 00:08:49,900 +الأسعار، تجارب الأسعار، تجارب الأسعار، تجارب + +106 +00:08:49,900 --> 00:08:50,360 +الأسعار، تجارب الأسعار، تجارب الأسعار، تجارب + +107 +00:08:50,360 --> 00:08:53,060 +الأسعار، تجارب الأسعار، تجارب الأسعار، تجارب + +108 +00:08:53,060 --> 00:08:58,640 +الأسعار، تجارب الأسعار، تجارب الأسعار، + +109 +00:08:58,640 --> 00:09:02,220 +تجارب الأسعار، تجارب الأسع + +110 +00:09:04,760 --> 00:09:07,060 +التأثير على مواجهة مواجهة مختلفة على تأثير السعر + +111 +00:09:07,060 --> 00:09:13,200 +السوقي إذا كانت السعر السوقي تفتح هذه المعلومة يجب + +112 +00:09:13,200 --> 00:09:19,960 +أن نلاحظ نتائج عادية أو عادية عادية إذا لم نلاحظ + +113 +00:09:19,960 --> 00:09:22,840 +هذا يعني أنه لا يوجد تأثير على المعلومات الجديدة + +114 +00:09:22,840 --> 00:09:27,870 +على السعر السوقييعني إذا احنا ماشوفناش في دور + +115 +00:09:27,870 --> 00:09:30,590 +المعلومات مابتدخلش في ال .. في ال .. في ال stock + +116 +00:09:30,590 --> 00:09:34,890 +price معناه كده مش هيكون في عندى abnormal return + +117 +00:09:34,890 --> 00:09:39,530 +نعطيكوا مثال for instance أنتوا الصفة بتاخدوا + +118 +00:09:39,530 --> 00:09:44,210 +investment روحنا نعمل عليكم امتحان روحنا بدنا + +119 +00:09:44,210 --> 00:09:48,010 +نعطيكم training course نعطيكم إيش training course + +120 +00:09:48,010 --> 00:09:53,010 +this class will take a training courseنعطيكم + +121 +00:09:53,010 --> 00:09:57,610 +training course دورة تدريبية في ال investment okay + +122 +00:09:57,610 --> 00:10:01,850 +هلأ بنشوف to evaluate whether this training course + +123 +00:10:01,850 --> 00:10:05,970 +is benefits or not يعني بنشوف هل هذا ال training + +124 +00:10:05,970 --> 00:10:10,790 +course مفيدة ولا لأ بنعملكوا exam pre the training + +125 +00:10:10,790 --> 00:10:13,550 +بنيجيكوا تعالوا يا بنات خدوا هالامتحان قبل ما + +126 +00:10:13,550 --> 00:10:16,270 +انتوا تروحوا على ال course ابتبوا معانا يا بناتها + +127 +00:10:16,270 --> 00:10:21,020 +بنعطيكوا examتفضلوا هاي ال exam تعملوا ال exams + +128 +00:10:21,020 --> 00:10:25,720 +and we record the results و بنسجل ايش؟ ال results + +129 +00:10:25,720 --> 00:10:30,080 +هذا بيسميها a pre the training for instance the + +130 +00:10:30,080 --> 00:10:35,060 +results seventy percent قبل الامتحان قبل ال + +131 +00:10:35,060 --> 00:10:39,620 +training فاللي روحنا أخدناكم أخدنا المجموعة هذه و + +132 +00:10:39,620 --> 00:10:43,300 +روحنا و دلناها training course okay بعد ما عملنا + +133 +00:10:43,300 --> 00:10:47,240 +training course we repeat the exam نعطيكم امتحان + +134 +00:10:47,240 --> 00:10:53,290 +آخرand we compare the past and the pre فإذا كان ال + +135 +00:10:53,290 --> 00:10:57,850 +past for instance eighty percent بنحكوا yes there + +136 +00:10:57,850 --> 00:11:02,270 +is impact of the training on the student + +137 +00:11:02,270 --> 00:11:07,110 +performance if there is no change seventy seventy + +138 +00:11:07,110 --> 00:11:10,970 +or seventy seventy oneOkay it means there is no + +139 +00:11:10,970 --> 00:11:14,510 +impact of the training so the training is a waste + +140 +00:11:14,510 --> 00:11:18,930 +of time يعني ال training هو تضيع وقت okay some + +141 +00:11:18,930 --> 00:11:22,070 +other people they said okay this is one approach + +142 +00:11:22,070 --> 00:11:25,590 +هذا approach ممكن احنا نحله نشوف ال post و نشوف ال + +143 +00:11:25,590 --> 00:11:28,890 +brief to calculate the abnormal rate of return + +144 +00:11:28,890 --> 00:11:34,610 +some people argue to use a proxy or a benchmarkبعض + +145 +00:11:34,610 --> 00:11:38,390 +الناس بيقول لأ خلينا نجرب نعمل proxy or benchmark، + +146 +00:11:38,390 --> 00:11:42,070 +إيش يعني proxy؟ نرجع لمثالنا بال students، حكينا + +147 +00:11:42,070 --> 00:11:45,530 +أن هدول البنات نعملهم training course and these + +148 +00:11:45,530 --> 00:11:50,230 +students they don't take any training course in + +149 +00:11:50,230 --> 00:11:54,320 +investmentso there is absence of training course + +150 +00:11:54,320 --> 00:11:57,560 +here absence مافيش في training course the training + +151 +00:11:57,560 --> 00:12:00,300 +courses are attending here يعني احنا هدول البنات + +152 +00:12:00,300 --> 00:12:03,160 +اعطاناهم training course و هدول ماعطاناهمش and we + +153 +00:12:03,160 --> 00:12:07,800 +give exam for both نعطي متحالة اتنين if the people + +154 +00:12:07,800 --> 00:12:09,840 +who take the exam + +155 +00:12:14,040 --> 00:12:16,920 +record a good result or higher result than these + +156 +00:12:16,920 --> 00:12:20,060 +people it means the training course works يعني + +157 +00:12:20,060 --> 00:12:25,160 +خلينا نشوف انه بنقارن ال group ال class ال class + +158 +00:12:25,160 --> 00:12:29,460 +مع benchmark عارفين إيش معناه benchmark؟ benchmark + +159 +00:12:29,460 --> 00:12:34,260 +يعني ناس زيهم بالظبط لكن ماخدوش training course + +160 +00:12:34,260 --> 00:12:40,200 +فإذا كان هدول بتاعون ال class اللي عملوا test ال + +161 +00:12:40,200 --> 00:12:42,820 +training course seventy percentوتعوني ال benchmark + +162 +00:12:42,820 --> 00:12:48,460 +70% جابوا في الاختبار so it is the same طبعا مافيش + +163 +00:12:48,460 --> 00:12:51,580 +مشكلة عامة يعني there is no impact of training + +164 +00:12:51,580 --> 00:12:56,740 +course لكن إذا وجدنا بتوع ال class جابوا 80% و ال + +165 +00:12:56,740 --> 00:13:01,680 +benchmark 70% it means the training course is work + +166 +00:13:01,680 --> 00:13:07,090 +or is workingطبعا يعني هاي طريقة تانية بن .. بن .. + +167 +00:13:07,090 --> 00:13:10,090 +بن .. بنشوف فيها ال abnormal later over time + +168 +00:13:10,090 --> 00:13:14,630 +another method we can compare the .. this class + +169 +00:13:14,630 --> 00:13:17,670 +with other classes with .. with the university هذا + +170 +00:13:17,670 --> 00:13:20,950 +بيسميها مع ال .. مع ال market كله بتشوف هدول الناس + +171 +00:13:20,950 --> 00:13:24,350 +مع ال market بتشوف how they make the difference + +172 +00:13:24,350 --> 00:13:28,650 +okay so this is the idea of the event studies هذه + +173 +00:13:28,650 --> 00:13:32,380 +فكرة ال event studiesالبحث الانبعاثي الانبعاثي + +174 +00:13:32,380 --> 00:13:36,620 +يسمح لنا باستخدام تأثير مواصلة حدث و انا اشرح ماذا + +175 +00:13:36,620 --> 00:13:41,660 +يعني حدث مواصلة حدث على قيمة شركة FM نشوف حدث معين + +176 +00:13:41,660 --> 00:13:45,780 +سكاندل صارت في تاريخ الشركة وشو أثرت على قيمة + +177 +00:13:45,780 --> 00:13:49,440 +الشركة نشوف مثلا إذا كان الشركة عندها ديفيدنس وشو + +178 +00:13:49,440 --> 00:13:54,200 +ال impact على قيمة الشركة الانبعاثي الانبعاثي التي + +179 +00:13:54,200 --> 00:13:58,950 +أشرحهاThe abnormal rate of return due to the event + +180 +00:13:58,950 --> 00:14:01,510 +is the difference between the stock's actual + +181 +00:14:01,510 --> 00:14:05,010 +return and a proxy for the stock's return in the + +182 +00:14:05,010 --> 00:14:09,030 +absence of the event يعني هو الفرق بين ال return + +183 +00:14:09,030 --> 00:14:14,090 +تبع السهم في + +184 +00:14:14,090 --> 00:14:18,810 +حالة ال event و return تبع السهم في حالة عدم وجود + +185 +00:14:18,810 --> 00:14:24,640 +ال eventمقارن بيناتهم او هو return تبع سهم معين + +186 +00:14:24,640 --> 00:14:27,820 +مقارن مع سهم اخر مافيش فيه event يعني يا اما + +187 +00:14:27,820 --> 00:14:33,440 +نقيصها هيك يا هيكيف ندرس ال event ال event ممكن + +188 +00:14:33,440 --> 00:14:38,760 +احنا نقارن ال pre مع ال post ال + +189 +00:14:38,760 --> 00:14:46,160 +pre بيكون في absence of the event هنا في attending + +190 +00:14:46,160 --> 00:14:50,980 +لل eventممكن احنا نقارل ال .. ال .. ال .. ال stock + +191 +00:14:50,980 --> 00:14:55,500 +with a benchmark و شرحنا ايش ال benchmark okay + +192 +00:14:55,500 --> 00:14:59,000 +يعني زي ال control group اللي بنعمل انه شركة فيه + +193 +00:14:59,000 --> 00:15:03,540 +صار فيها event و شركة ماصارش فيها eventOkay يعني + +194 +00:15:03,540 --> 00:15:06,600 +شركة وزعت أرباح وشركة ماوزعتش أرباح الشركة صار + +195 +00:15:06,600 --> 00:15:08,760 +فيها scandal وشركة ماصارش فيها scandal scandal + +196 +00:15:08,760 --> 00:15:12,780 +يعني فضيحة الشركة صار فيها leaking لل petrol وشركة + +197 +00:15:12,780 --> 00:15:15,780 +ماصارش فيها leaking لل petrol عشان تشوف the impact + +198 +00:15:15,780 --> 00:15:19,560 +of the stock price on both companies ممكن اللي + +199 +00:15:19,560 --> 00:15:22,700 +يصير أننا فيه ليش احنا بنعمل control group لأن + +200 +00:15:22,700 --> 00:15:26,000 +ممكن other factors تخلي الشركتان يزيدوا ال + +201 +00:15:26,000 --> 00:15:29,350 +performance بتاعتهمفمنها احنا لما نحيد ال other + +202 +00:15:29,350 --> 00:15:32,710 +factors تصير عندي بس انه اختار شركة صار فيها event + +203 +00:15:32,710 --> 00:15:36,950 +و شركة ماصارش فيها event ممكن اختار ال stock نفسه + +204 +00:15:36,950 --> 00:15:42,410 +معاش مع ال markets زي ما حكينا ال class مع الجامعة + +205 +00:15:42,410 --> 00:15:48,230 +كلها و نشوف to compare the performance most + +206 +00:15:48,230 --> 00:15:53,510 +of studies on the event studies focus on the + +207 +00:15:53,510 --> 00:15:56,290 +market model comparing the stock performance with + +208 +00:15:56,290 --> 00:16:00,690 +the marketيعني أغلب الدراسات ركزت على ال stock + +209 +00:16:00,690 --> 00:16:04,230 +performance و ال market okay how we examine this + +210 +00:16:04,230 --> 00:16:09,010 +how test our structures how we examine the event + +211 +00:16:09,010 --> 00:16:12,250 +studies returns are adjusted to determine if they + +212 +00:16:12,250 --> 00:16:17,990 +are abnormal يعني احنا بنحاول نعمل adjusting تعديل + +213 +00:16:17,990 --> 00:16:22,330 +لل return حتى انه احنا نشوف is abnormal ولا مش + +214 +00:16:22,330 --> 00:16:27,550 +abnormal نيجي نشرح ال market abnormal return + +215 +00:16:32,960 --> 00:16:38,580 +R is the return of stock at T-time يعني هو عائد + +216 +00:16:38,580 --> 00:16:44,480 +ثهم عند نقطة معينة من الزمن R at T-time is equal + +217 +00:16:44,480 --> 00:16:48,700 +alpha and I will explain what it means alpha plus + +218 +00:16:48,700 --> 00:16:59,630 +theta RMT plus epsilon at T-time look at hereهذه + +219 +00:16:59,630 --> 00:17:04,790 +هي سيكورتي ماركت لاين اعتقد انك تتذكر هذا لذلك + +220 +00:17:04,790 --> 00:17:13,810 +إعادة اي شركة إعادة هذه الشركة على سبيل المثال هي + +221 +00:17:13,810 --> 00:17:22,030 +تعتبر هذه إعادة Alpha يعني إعادة Alpha زائد + +222 +00:17:22,030 --> 00:17:27,450 +هذه النقطة لذلك إعادة شركة واحدة على سبيل المثال + +223 +00:17:27,450 --> 00:17:33,300 +شركة Aيعني العائد لـ stock A هيساوي .. تشايفين + +224 +00:17:33,300 --> 00:17:40,800 +الحتة هذه .. هي Alpha A plus this .. so this is + +225 +00:17:40,800 --> 00:17:49,560 +Alpha and this one is this .. because this is like + +226 +00:17:49,560 --> 00:17:55,310 +slopeSo we cannot easily measure this, we have to + +227 +00:17:55,310 --> 00:17:59,690 +measure the slope of this, I think in mathematical + +228 +00:17:59,690 --> 00:18:02,950 +we have to use some mathematical solutions to do + +229 +00:18:02,950 --> 00:18:08,690 +this, so to calculate this it means to calculate + +230 +00:18:08,690 --> 00:18:09,250 +tan theta + +231 +00:18:12,000 --> 00:18:14,560 +at the end of the day you don't need to spoil your + +232 +00:18:14,560 --> 00:18:17,640 +mind on understanding these things this is the + +233 +00:18:17,640 --> 00:18:23,500 +equation beta is the slope of this line with + +234 +00:18:23,500 --> 00:18:27,420 +regard to this line يعني ميل الخط المستقيم هذا + +235 +00:18:27,420 --> 00:18:34,680 +الخط على محور اللي هو السينات okay بس ال M T + +236 +00:18:38,790 --> 00:18:44,270 +هي ال market return بالعربي this is what you want + +237 +00:18:44,270 --> 00:18:52,090 +العائد لأي سهم بيساوي Alpha جزء المخطوعة هذا معروف + +238 +00:18:52,090 --> 00:18:55,350 +ماعنداش مشكلة اللي هو systematic risk مخاطر نظامية + +239 +00:18:55,350 --> 00:18:59,950 +زائد sensitivity beta هي sensitivity sensitivity + +240 +00:18:59,950 --> 00:19:08,800 +معناها إيش حساسية السهم لتغيرات السوقحساسية السهم + +241 +00:19:08,800 --> 00:19:14,980 +beta هذه حساسية السهم لتغيرات في عائد السوق بس ال + +242 +00:19:14,980 --> 00:19:20,580 +epsilon هذه نسبة الخطأ ال abnormal return هذه نسبة + +243 +00:19:20,580 --> 00:19:25,960 +الخطأ هتشوفها قبل chart إيش بتساوي طلعوا بس ركزوا + +244 +00:19:25,960 --> 00:19:31,180 +معايا شوية ركزوا معايا لأن هذا إشي لازم تفهموا + +245 +00:19:31,180 --> 00:19:35,310 +عشان تفهموا ال epsilon هذهعشان تفهم اياش ال + +246 +00:19:35,310 --> 00:19:38,030 +epsilon لإنه most of the researchers they + +247 +00:19:38,030 --> 00:19:42,530 +particularly in the in the current studies in the + +248 +00:19:42,530 --> 00:19:44,750 +low quality studies you know what means low + +249 +00:19:44,750 --> 00:19:49,930 +quality studies دراسات + +250 +00:19:49,930 --> 00:19:55,490 +ضعيفة they ignore epsilon and this is a very + +251 +00:19:55,490 --> 00:19:58,930 +important to consider epsilon what it means + +252 +00:19:58,930 --> 00:20:05,970 +epsilon شوفوا كيفشايفين الخط هذا؟ هذا in the real + +253 +00:20:05,970 --> 00:20:08,570 +world في العالم الحقيقي there is no straight line + +254 +00:20:08,570 --> 00:20:13,930 +okay the straight line is this is expected this is + +255 +00:20:13,930 --> 00:20:19,860 +expectedthis is what should be the prices or what + +256 +00:20:19,860 --> 00:20:23,320 +should be the security market lines and this is + +257 +00:20:23,320 --> 00:20:28,700 +the optimal things هذا هو متوقع but the actual is + +258 +00:20:28,700 --> 00:20:35,360 +going like this ال actual هو like this yes is + +259 +00:20:35,360 --> 00:20:38,820 +moving around the expected + +260 +00:20:41,530 --> 00:20:45,090 +and you know this you know that this is deviation + +261 +00:20:45,090 --> 00:20:53,350 +or this is like error which is epsilon okay which + +262 +00:20:53,350 --> 00:20:58,690 +is epsilon if epsilon look again look back to the + +263 +00:20:58,690 --> 00:21:02,650 +chart again and look carefully تطلعوا على ال chart + +264 +00:21:02,650 --> 00:21:06,770 +كمان مرة و بحذر تطلعوا if you look at this chart + +265 +00:21:06,770 --> 00:21:12,990 +carefully and see what you observe on thisإيش + +266 +00:21:12,990 --> 00:21:16,930 +بتلاحظه بال charts؟ okay this is around what they + +267 +00:21:16,930 --> 00:21:20,950 +expected one more observation if you just + +268 +00:21:20,950 --> 00:21:26,510 +scrutinize if you in depth look at the .. وين + +269 +00:21:26,510 --> 00:21:30,190 +بتشوفوا بتشوفوا ال return أعلى ال deviation أعلى + +270 +00:21:30,190 --> 00:21:34,110 +ولا أقل؟ أقلشوفوها ال deviation فهذا بيصير + +271 +00:21:34,110 --> 00:21:37,970 +positive abnormal return شايفين positive يعني ال + +272 +00:21:37,970 --> 00:21:40,790 +deviation أعلى من الخط أعلى من ال deviation اللي + +273 +00:21:40,790 --> 00:21:45,850 +تحت so this is positive abnormal return okay so + +274 +00:21:45,850 --> 00:21:49,370 +let's go back to this equation we didn't finish + +275 +00:21:49,370 --> 00:21:53,610 +yet so + +276 +00:21:53,610 --> 00:21:59,170 +what is et which is the abnormal rate of return + +277 +00:22:00,230 --> 00:22:06,030 +which is equal to the actual rate of return minus + +278 +00:22:06,030 --> 00:22:11,230 +the expected rate of return abnormal rate of + +279 +00:22:11,230 --> 00:22:14,970 +return is equal to the actual rate of return minus + +280 +00:22:14,970 --> 00:22:19,150 +the expected rate of return so epsilon is the + +281 +00:22:19,150 --> 00:22:22,210 +abnormal rate of return which is equal to the + +282 +00:22:22,210 --> 00:22:27,430 +actual minus the expected rate of returnlook at + +283 +00:22:27,430 --> 00:22:30,570 +this chart again just to remind you and to + +284 +00:22:30,570 --> 00:22:34,330 +flashing back your mind يعني دايما انا بحب اذكركم + +285 +00:22:34,330 --> 00:22:44,730 +بال charts if you look at this here so + +286 +00:22:44,730 --> 00:22:51,750 +this blue line is the expected okay and this is + +287 +00:22:51,750 --> 00:22:55,250 +the the black one is the actual + +288 +00:22:58,950 --> 00:23:04,310 +So the AT which is the abnormal rate of return is + +289 +00:23:04,310 --> 00:23:09,410 +the actual minus the expected if actual is equal + +290 +00:23:09,410 --> 00:23:13,450 +to expected it means there is no abnormal return + +291 +00:23:13,450 --> 00:23:19,930 +إذا if you observe like this and you see the + +292 +00:23:19,930 --> 00:23:30,990 +actual is you see is likeclose to the .. so it + +293 +00:23:30,990 --> 00:23:34,410 +means this is insignificant insignificant change + +294 +00:23:34,410 --> 00:23:42,290 +it means هي the actual equal the expected so + +295 +00:23:42,290 --> 00:23:50,930 +our mission is to estimate the Eوهي كمية الواقع + +296 +00:23:50,930 --> 00:23:54,610 +الذي يتجاوز من الواقع المتوقع وهو الـ Abnormal + +297 +00:23:54,610 --> 00:23:57,630 +Rate of Return لذلك Abnormal Rate of Return مرة + +298 +00:23:57,630 --> 00:24:01,210 +أخرى فقط لتحريك المقارنة كما قلت هذا هو الواقع + +299 +00:24:01,210 --> 00:24:05,130 +وهذا + +300 +00:24:05,130 --> 00:24:10,970 +هو الواقع المتوقع وهو مرة أخرى الواقع المتوقع هو + +301 +00:24:10,970 --> 00:24:11,150 +هذا + +302 +00:24:34,190 --> 00:24:39,090 +فهمتوا هالمعادلة؟ very simple طيب هلا افتح صفحه + +303 +00:24:39,090 --> 00:24:47,060 +354شوف صفحة 354 في عندكم مثال suppose that the + +304 +00:24:47,060 --> 00:24:50,620 +analyst has estimated Alpha انتبهوا يا بنات + +305 +00:24:50,620 --> 00:24:56,000 +افترضوا ان ال analyst estimated Alpha اتوقعوا + +306 +00:24:56,000 --> 00:25:03,360 +Alpha and you know what it means Alpha Alpha is 0 + +307 +00:25:03,360 --> 00:25:10,060 +.05% طب عارفين where is Alpha هاي Alpha okayand + +308 +00:25:10,060 --> 00:25:15,920 +beta point eight ايش معناه beta point eight؟ في حد + +309 +00:25:15,920 --> 00:25:19,980 +بيعرفه تتميز beta؟ هاذي ال slope بتاع هذا بيسميه + +310 +00:25:19,980 --> 00:25:22,440 +beta او beta + +311 +00:25:25,890 --> 00:25:29,450 +إذا ال market تبقى إيش معناه what it means ألف + +312 +00:25:29,450 --> 00:25:34,190 +بيتا بيتا it means هي ال slope تبع هذا slope طبعا + +313 +00:25:34,190 --> 00:25:37,650 +ماعرفش أنتوا بال .. أخدتوا mathematic تمليح ولا لأ + +314 +00:25:37,650 --> 00:25:41,350 +المال اللي هو slope إيش معناه ال .. ال .. ال beta + +315 +00:25:41,350 --> 00:25:46,390 +slope يعني إذا تغير ال market واحدة واحدة فالسوق + +316 +00:25:46,390 --> 00:25:51,610 +هيتغير point eight عفوا ال return يعني إذا طلع + +317 +00:25:51,610 --> 00:25:56,050 +عشرة في المية السوقالسهم بيطلع تمانية في المية + +318 +00:25:56,050 --> 00:26:00,790 +وإذا نزل أشرة في المية السهم بنزل تمانية في المية + +319 +00:26:00,790 --> 00:26:06,290 +okay that's it طيب so this is beta كام beta كانت + +320 +00:26:06,290 --> 00:26:15,670 +point eight on a day that the markets go up on + +321 +00:26:15,670 --> 00:26:20,090 +the day of the market goes up by one percent you + +322 +00:26:20,090 --> 00:26:22,590 +would predict from the equation إذا السوق اتطلع + +323 +00:26:22,590 --> 00:26:26,710 +واحد في الميةOkay that the stock should rise by + +324 +00:26:26,710 --> 00:26:29,810 +the expected value of خليني أقول السوق جديد صار + +325 +00:26:29,810 --> 00:26:34,130 +طبق المعادلة يا بناتي بدنا نحسب ال R normal مرتين + +326 +00:26:34,130 --> 00:26:40,830 +ايش عندنا احنا؟ في عندنا الف كام؟ خمسة في المين + +327 +00:26:40,830 --> 00:26:50,590 +زائد بيتا كام؟ point eight و ال RMT كام؟ point + +328 +00:26:50,590 --> 00:27:03,910 +واحد صح؟ طيب0.0% 1% احسبوها شوفوا كده تطلع بطلع + +329 +00:27:03,910 --> 00:27:10,370 +الجوا بال RT كام 8.5% طيب عشان نحسب ال up normal + +330 +00:27:10,370 --> 00:27:16,350 +تاني لو السوق بدل ما هو 1% طلع 2% مش هنسوي هنعيد + +331 +00:27:16,350 --> 00:27:28,220 +نفس الخطوة 5% زي 0.8 ضرب 0.02بطلع كام؟ بطلع .. + +332 +00:27:28,220 --> 00:27:33,260 +شوفوا كام بطلع عنكم طبعا + +333 +00:27:33,260 --> 00:27:36,900 +ال abnormal التاني هو الفرق بيناتهم هذا المثال + +334 +00:27:36,900 --> 00:27:49,260 +okay المثال هذا موجود في صفحة 354 استني + +335 +00:27:49,260 --> 00:27:49,640 +شوية + +336 +00:27:53,020 --> 00:28:00,520 +انتوا هذا واضح عندكم صح هذا + +337 +00:28:00,520 --> 00:28:07,240 +خلينا هذا خمسة في المية له ال alpha plus point + +338 +00:28:07,240 --> 00:28:10,720 +eight beta اجمعيهم مع بعض كم بيطلع + +339 +00:28:19,730 --> 00:28:24,450 +لأ خلينا بس انت حسبينها لو خلصينها منها حسبتها طب + +340 +00:28:24,450 --> 00:28:28,110 +حسبيها كام تطلع اللي هو point eight five percent + +341 +00:28:28,110 --> 00:28:39,830 +طبعا طب + +342 +00:28:39,830 --> 00:28:49,240 +إذا كان خلصنا عند اللحظة هذهطب إذا كان .. انتبهوا + +343 +00:28:49,240 --> 00:28:56,200 +كمان ..كمل هان إذا كان ال .. ال R .. ال RT بعد + +344 +00:28:56,200 --> 00:29:02,280 +ال event حسبناها .. بعد ال event طلعت 2% كم ال + +345 +00:29:02,280 --> 00:29:09,460 +abnormality تاني؟ كم ال abnormality تاني؟ طب احنا + +346 +00:29:09,460 --> 00:29:12,100 +طلعت هنا point eight five percent + +347 +00:29:14,830 --> 00:29:17,150 +يعني جابني ال event كانت point eight five percent + +348 +00:29:17,150 --> 00:29:26,670 +هذا ال expected أو اللي قبل لما بعد ال event اتنية + +349 +00:29:26,670 --> 00:29:30,390 +في المية حسبنا ال RT طلعت اتنية في المية هذا معطاه + +350 +00:29:30,390 --> 00:29:35,810 +أداش ال abnormal return قبل ال event اتنية في + +351 +00:29:35,810 --> 00:29:41,390 +المية معقص بيطلع point eight point two eight معقص + +352 +00:29:41,390 --> 00:29:41,810 +point + +353 +00:30:09,750 --> 00:30:20,330 +الـ RT ماعطيكوا يعنىبعد ال event بتساوي 2% قبل ال + +354 +00:30:20,330 --> 00:30:25,470 +event حسبناها اللي هي 0.85% اللي هي هذه بحسب + +355 +00:30:25,470 --> 00:30:29,470 +المعادلة بتراجعوا + +356 +00:30:29,470 --> 00:30:40,830 +المثال في صفحه 354 خلينا + +357 +00:30:40,830 --> 00:30:50,360 +نركز احناال RT نتوقعها صح اللي هي ال expected + +358 +00:30:50,360 --> 00:30:54,480 +حكينا احنا ايش ال actual minus the expected ال + +359 +00:30:54,480 --> 00:31:01,360 +abnormal اللي هي E بتساوي ال actual minus the + +360 +00:31:01,360 --> 00:31:05,940 +expected طيب ال actual معروفة عندي انا عارفها اللي + +361 +00:31:05,940 --> 00:31:12,360 +هو اتنين في الميةمعروفة بدّي ال expected ال + +362 +00:31:12,360 --> 00:31:16,020 +expected لازم أحسبها فبدا أحسبها في عند ال alpha + +363 +00:31:16,020 --> 00:31:20,400 +خمسة في المية عند ال beta point eight و عند ال MT + +364 +00:31:20,400 --> 00:31:25,260 +ال RMT point one نضربهم في بعض market return + +365 +00:31:25,260 --> 00:31:29,780 +market return okay فحكيلي في السؤال market return + +366 +00:31:29,780 --> 00:31:35,660 +increase by one percent مظبوط فالعوضناعوضناها + +367 +00:31:35,660 --> 00:31:39,200 +نعوضناها نطلع لنا إيش ال expected ال expected كام + +368 +00:31:39,200 --> 00:31:43,940 +point eight five percent نجت ناقص ناقص ناقص ناقص + +369 +00:31:43,940 --> 00:31:46,540 +ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص + +370 +00:31:46,540 --> 00:31:46,720 +ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص + +371 +00:31:46,720 --> 00:31:47,300 +ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص + +372 +00:31:47,300 --> 00:31:50,500 +ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص ناقص + +373 +00:31:50,500 --> 00:32:00,580 +ناقص ناقص ناقص ناق + +374 +00:32:01,390 --> 00:32:06,690 +إيش القانون اللي بيحكي ال RT the expected okay + +375 +00:32:06,690 --> 00:32:11,610 +minus the actual ال + +376 +00:32:11,610 --> 00:32:17,190 +expected توقع بدلالة هدول اللي احنا طلعناها اللي + +377 +00:32:17,190 --> 00:32:20,870 +هو Alpha زائد هذا و ال ET ما احنا مش عارفينها okay + +378 +00:32:20,870 --> 00:32:26,070 +فاحنا هذه ال ET جيبناها بدلالة RT minus يعني هذه + +379 +00:32:26,070 --> 00:32:30,490 +المعادلة هذا معروف و هذا معروف بس هذا مش معروف + +380 +00:32:33,980 --> 00:32:37,580 +طبعا فبنجيب و نجيب ال AT و نجيب الدلالة هذه هذي ال + +381 +00:32:37,580 --> 00:32:43,380 +RT معطيك إياها و Alpha هذي معطيك إياها فبنجيب ال + +382 +00:32:43,380 --> 00:32:49,240 +AT هذي + +383 +00:32:49,240 --> 00:32:54,440 +هذي نفسها هذي .. هذي لازم أولا نطبق هذي و بعدها + +384 +00:32:54,440 --> 00:33:00,120 +نطبق هذي عشان نجيب هذي طبعا بكفي هذي و ان شاء الله + +385 +00:33:00,120 --> 00:33:00,920 +الدرجة هيكمل + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/iRmUeYH3Y2Q.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/iRmUeYH3Y2Q.srt new file mode 100644 index 0000000000000000000000000000000000000000..899945ec72a582e8d52ecde43b079f8133ef74ca --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/iRmUeYH3Y2Q.srt @@ -0,0 +1,2993 @@ +1 +00:00:21,800 --> 00:00:25,040 +بسم الله الرحمن الرحيم اليوم زي ما احنا حكينا + +2 +00:00:25,040 --> 00:00:30,420 +معاكم المرة الفاتة أنه كيف تكتبوا الـ assignments الواجب تبعكم + +3 +00:00:30,420 --> 00:00:34,880 +فحنركز اليوم على writing up + +4 +00:00:34,880 --> 00:00:37,600 +your university assignments كيف نكتب الـ + +5 +00:00:37,600 --> 00:00:43,660 +university assignments تبعناها، اه لأنه لما + +6 +00:00:43,660 --> 00:00:48,610 +احنا نعمل الواجب تبعنا، الـ reader يعني + +7 +00:00:48,610 --> 00:00:52,530 +الـ أستاذ تبعكم بده يقرأ الـ واجبات + +8 +00:00:52,530 --> 00:00:57,390 +فهو he or she cannot put it in the shelf + +9 +00:00:57,390 --> 00:01:03,260 +unless he is reading your work، فهو لازم يقرأ الـ + +10 +00:01:03,260 --> 00:01:08,700 +الشغل تبعكم، فعشان احنا ناخد علامات منيحة في الـ + +11 +00:01:08,700 --> 00:01:13,100 +assignment، okay، في we have to follow the + +12 +00:01:13,100 --> 00:01:16,920 +quality of assignments، how to write the assignment + +13 +00:01:16,920 --> 00:01:23,800 +so it includes two main textbooks، how to write + +14 +00:01:23,800 --> 00:01:26,700 +the assignment، هذا أول textbook زي ما أنتم + +15 +00:01:26,700 --> 00:01:30,740 +شايفينه، Writing up your university assignment، Okay + +16 +00:01:30,740 --> 00:01:37,680 +هذا textbook is important، مهم كثير بالخصوص للـ + +17 +00:01:37,680 --> 00:01:41,000 +investments، هذا لأي شيء ممكن بكرا ما تعملوا + +18 +00:01:41,000 --> 00:01:47,180 +الـ بحث التخرج مثلاً، بتكونوا بتعملوا مثلاً لما + +19 +00:01:47,180 --> 00:01:49,940 +تطلعوا على شغلكم مثلاً، تروحوا تشتغلوا في مؤسسات، how + +20 +00:01:49,940 --> 00:01:55,080 +to write a report، كيف نكتب تقرير، فكثير كويس إن + +21 +00:01:55,080 --> 00:01:58,700 +أنتم تاخدوا هذا الـ هذا الكتاب، وخصوصاً إن هذا + +22 +00:01:58,700 --> 00:02:08,180 +الكتاب يعني موجود ويدرس في يعني في جامعات يعني + +23 +00:02:08,180 --> 00:02:11,400 +أخذت high quality في الـ في الـ writing، okay + +24 +00:02:11,400 --> 00:02:15,480 +هنأخذ بس يعني مختصر، عشان إيش الكتاب هذا يعني إيش + +25 +00:02:15,480 --> 00:02:19,880 +بيحكي قبل ما احنا ندخل في تفاصيل المحاضرة تبعتنا + +26 +00:02:19,880 --> 00:02:23,840 +اليوم، طبعاً بيحكي the fundamentals of academic + +27 +00:02:23,840 --> 00:02:32,140 +writing، أساسيات في الـ academic writing، okay، بدنا + +28 +00:02:32,140 --> 00:02:35,280 +قبل ما نبدأ الـ assignments، أولاً بدنا نعرف what is + +29 +00:02:35,280 --> 00:02:38,540 +the assignment about؟ إيش هو؟ عن إيش بيحكي الـ + +30 +00:02:38,540 --> 00:02:40,580 +assignments؟ هل أنتم بتعملوا analysis بالـ + +31 +00:02:40,580 --> 00:02:44,620 +assignments؟ ولا أنتم just explain ideas؟ ولا + +32 +00:02:44,620 --> 00:02:49,760 +أنتم بتحطوا ideas؟ هل هو descriptive؟ يعني وصفي؟ + +33 +00:02:49,760 --> 00:02:55,570 +توصفوا شغلة معينة؟ you are exploratory؟ بتكتشفوا + +34 +00:02:55,570 --> 00:03:01,090 +شغلة معينة أو بتركزوا على مواضيع معينة، فـ بدنا + +35 +00:03:01,090 --> 00:03:04,210 +نعرف why we are using academic writing؟ ليش احنا + +36 +00:03:04,210 --> 00:03:08,150 +بنستخدم الـ academic writing؟ يعني التقارير + +37 +00:03:08,150 --> 00:03:12,690 +الأكاديمية والدراسات الأكاديمية، تمام؟ ثاني شغلة + +38 +00:03:12,690 --> 00:03:17,870 +how should I structure my writing؟ كيف أنا أرتب الـ + +39 +00:03:17,870 --> 00:03:21,870 +writing تبعي؟ أهم شيء في الـ writing يكون في + +40 +00:03:21,870 --> 00:03:25,980 +عندي شغلة اسمها coherence، coherence، إيش معناه + +41 +00:03:25,980 --> 00:03:29,780 +coherence؟ تماسك، يعني من أول الموضوع لآخر الموضوع + +42 +00:03:29,780 --> 00:03:35,720 +كله فيه ترابط، يعني احنا لو جينا مثلاً هان عادة + +43 +00:03:35,720 --> 00:03:40,260 +بيكون في عندنا the main idea بتاعة الـ assignment هاي + +44 +00:03:40,260 --> 00:03:46,780 +الـ main idea، بعدين في ideas أخرى مرتبطة في الـ main + +45 +00:03:46,780 --> 00:03:51,500 +ideas، احنا بتبدأ نتوسع في هذه الـ ideas، زي ما أنتم + +46 +00:03:51,500 --> 00:03:57,100 +شايفين، فـ every part of the ideas is connected with + +47 +00:03:57,100 --> 00:04:02,340 +the main ideas، كل جزء من الـ الأفكار + +48 +00:04:02,340 --> 00:04:05,520 +الفرعية مرتبط بالفكرة الرئيسية، فهذا بيسموه + +49 +00:04:05,520 --> 00:04:08,860 +coherence، يكون في عنده ترابط، يعني مثلاً لما أنا + +50 +00:04:08,860 --> 00:04:12,860 +بحكي عن behavioral finance، هو واحد من الـ + +51 +00:04:12,860 --> 00:04:17,830 +الأسئلة اللي مطلوبة منكم، behavioral finance، في الـ + +52 +00:04:17,830 --> 00:04:21,790 +main idea، I should define what is the idea of behavioral finance، شو هي behavioral + +54 +00:04:24,550 --> 00:04:28,910 +finance، تمام؟ و all of these ideas are linked with + +55 +00:04:28,910 --> 00:04:34,870 +the main idea، تمام؟ الكل بيكون مرتبط بالـ main idea، for instance، the behavioral + +57 +00:04:37,910 --> 00:04:44,990 +finance is considered the market is not efficient، + +58 +00:04:44,990 --> 00:04:50,690 +for instance، Okay، and you discuss this concept، و + +59 +00:04:50,690 --> 00:04:55,090 +احنا بتبدأ نناقش هذا الـ concept within the other + +60 +00:04:55,090 --> 00:05:00,830 +ideas، your eyes focusing on the main ideas and the + +61 +00:05:00,830 --> 00:05:04,150 +secondary ideas are related to the main idea، يعني + +62 +00:05:04,150 --> 00:05:07,690 +بتكون الفكرة الفرعية مرتبطة بالفكرة الرئيسية، هذا + +63 +00:05:07,690 --> 00:05:12,550 +بيسموه coherence، بيسمي إيش؟ coherence، تلعبت في بعض + +64 +00:05:12,550 --> 00:05:16,190 +الطلاب لما شوفنا الـ assignments تبعتهم، بيحكي + +65 +00:05:16,190 --> 00:05:19,710 +بموضوع، بعدين بنتخلع موضوع ثاني، وبعدين بنتخلع + +66 +00:05:19,710 --> 00:05:23,930 +موضوع ثالث، and so on، مافيش لما نقرأ you are + +67 +00:05:23,930 --> 00:05:26,810 +like when you are reading your assignments you + +68 +00:05:26,810 --> 00:05:31,190 +are like narrating a story زي ما احنا بنحكي قصة + +69 +00:05:31,190 --> 00:05:34,730 +it's it has introduction، main body and the + +70 +00:05:34,730 --> 00:05:38,930 +conclusion، if you mislead the reader in your + +71 +00:05:38,930 --> 00:05:43,150 +writing style، it means you don't have efficient + +72 +00:05:43,150 --> 00:05:46,800 +academic writing، يعني إذا أنتم you are misleading + +73 +00:05:46,800 --> 00:05:51,880 +the reader، يعني يعني مابتواجهوش الـ + +74 +00:05:51,880 --> 00:05:54,840 +reader صح، معناه كلمة you mislead the reader + +75 +00:05:54,840 --> 00:05:59,220 +بالأخير مافيش quality، مافيش efficiency، so there is + +76 +00:05:59,220 --> 00:06:03,360 +no need for your reward، يعني هلا مثلاً لما بنروح + +77 +00:06:03,360 --> 00:06:06,600 +احنا نكتب reward about يعني واحنا صغار كانوا + +78 +00:06:06,600 --> 00:06:09,680 +يدرسونا أنه نكتب تقرير على أنه رحلة إلى البحر + +79 +00:06:09,680 --> 00:06:15,880 +بينفعش نروح والله اتغذينا في البحر وروحنا، So it's + +80 +00:06:15,880 --> 00:06:19,640 +from the beginning starting the idea أنه رحلة إلى + +81 +00:06:19,640 --> 00:06:24,280 +البحر، تمام، ونبدأ ندخل فيه بعد ما فكرة الرحلة، و + +82 +00:06:24,280 --> 00:06:27,300 +بعدين ندخل في التفاصيل، والconclusion تماماً، طيب + +83 +00:06:27,300 --> 00:06:32,160 +فهذه أول أول chapter بحكي the functions + +84 +00:06:32,160 --> 00:06:37,400 +of، ثاني chapter هو الـ structure بتاعة + +85 +00:06:37,400 --> 00:06:41,440 +الـ thesis أو بتاعة الـ academic writing، حكينا على + +86 +00:06:41,440 --> 00:06:47,380 +الـ coherence، التماسك، يعني كل جزء كبير بتماسك بالـ + +87 +00:06:47,380 --> 00:06:49,900 +بالجزء الكبير، يعني مثلاً خلينا نحكي رحلة إلى + +88 +00:06:49,900 --> 00:06:55,440 +البحر، بينفعش مثلاً في في رقم في فكرة من + +89 +00:06:55,440 --> 00:07:00,700 +الأفكار هان موجود، والله واتفرجنا على فيلم وكان + +90 +00:07:00,700 --> 00:07:04,640 +كثير ممتع، طبعاً هذا هذا مش في البحر صار، is not + +91 +00:07:04,640 --> 00:07:08,060 +related، So why you are include this؟ Because some + +92 +00:07:08,060 --> 00:07:11,940 +people they want to stuff their writing، إيش + +93 +00:07:11,940 --> 00:07:17,080 +يستفيدوا؟ يحشوا، في ناس بس بدهم يحشوا، بس بدهم يحكوا + +94 +00:07:17,080 --> 00:07:22,100 +أي شيء، وأنا أحكي أي شيء، we don't need this، + +95 +00:07:22,100 --> 00:07:27,040 +okay؟ يعني زي ما بيحكوا مقلة ودل، دائماً بيسألوا + +96 +00:07:27,040 --> 00:07:30,620 +بيقولوا لي إيش الـ how many pages we can write + +97 +00:07:30,620 --> 00:07:36,520 +write as much as you want، اكتب قد ما بدك، as + +98 +00:07:36,520 --> 00:07:41,340 +much as I understand، قد ما أنا أفهم إنه يعني you + +99 +00:07:41,340 --> 00:07:44,520 +conclude your ideas، okay، to the level that I + +100 +00:07:44,520 --> 00:07:48,260 +understand your writing، فأول شيء حكينا إذا الـ + +101 +00:07:48,260 --> 00:07:53,360 +coherence واضحة، what it means coherence، كله تماسك + +102 +00:07:53,360 --> 00:07:56,800 +okay، يعني احنا بنحكي مثلاً على الـ the mechanisms + +103 +00:07:56,800 --> 00:08:01,420 +of of Palestinian Stock Exchange or the trading + +104 +00:08:01,420 --> 00:08:03,560 +mechanisms in Palestinian Palestine Stock + +105 +00:08:03,560 --> 00:08:07,740 +Exchange، يعني احنا بنحكي عن آلية التداول في سوق + +106 +00:08:07,740 --> 00:08:11,960 +فلسطين أوراق المالية، okay، the main idea is the + +107 +00:08:11,960 --> 00:08:16,140 +trading mechanisms، you + +108 +00:08:16,140 --> 00:08:20,660 +are talking about trading mechanisms، Okay، so the + +109 +00:08:20,660 --> 00:08:23,500 +first question or I think this is the third + +110 +00:08:23,500 --> 00:08:26,380 +question in your assignment، explain the trading + +111 +00:08:26,380 --> 00:08:31,260 +mechanisms and the market participants in your in + +112 +00:08:31,260 --> 00:08:34,660 +Palestine Stock Exchange، So this assignment + +113 +00:08:34,660 --> 00:08:37,580 +includes two main ideas، هذا بيشتمل two main ideas + +114 +00:08:37,580 --> 00:08:41,500 +the first one is the trading mechanisms، okay، the + +115 +00:08:41,500 --> 00:08:45,060 +second one is the market participants، يعني trading + +116 +00:08:45,060 --> 00:08:49,950 +mechanisms يعني آلية التداول في السوق، و الـ و الـ + +117 +00:08:49,950 --> 00:08:54,050 +second idea is talking about the market + +118 +00:08:54,050 --> 00:08:57,770 +participants، فلو أجينا احنا الـ ideas هان هنقسمها + +119 +00:08:57,770 --> 00:09:02,090 +في اسمين، هيكون القسم الأول trading mechanisms، we + +120 +00:09:02,090 --> 00:09:04,750 +are talking about trading mechanisms and related + +121 +00:09:04,750 --> 00:09:07,950 +ideas، وبعدين القسم الثاني في عندنا second main + +122 +00:09:07,950 --> 00:09:11,610 +idea talking about market participants، market + +123 +00:09:11,610 --> 00:09:16,040 +participants، خلينا نركز بس على هذا السؤال ونشوف + +124 +00:09:16,040 --> 00:09:18,740 +how we can deal with this question، كيف ممكن احنا + +125 +00:09:18,740 --> 00:09:22,840 +نعالج هذا السؤال؟ طيب ما زلنا نحكي عن الـ structure + +126 +00:09:22,840 --> 00:09:26,320 +the structure of your academic writing حكينا عن ال + +127 +00:09:26,320 --> 00:09:28,880 +coherence الشغل الثاني بال structure you have to + +128 +00:09:28,880 --> 00:09:33,840 +be careful with the referencing لازم تاخد بالك من + +129 +00:09:33,840 --> 00:09:38,900 +ال references avoid plagiarism what it means + +130 +00:09:38,900 --> 00:09:41,460 +plagiarism? plagiarism + +131 +00:09:45,140 --> 00:09:47,260 +plagiarism means أنه to copy and paste from + +132 +00:09:47,260 --> 00:09:49,640 +others, you claim this is your work and this is + +133 +00:09:49,640 --> 00:09:52,600 +not your work يعني أنت بتقول إن هذا شغلك و في + +134 +00:09:52,600 --> 00:09:58,260 +الواقع هذا مش شغلك, try to avoid plagiarism, here + +135 +00:09:58,260 --> 00:10:05,080 +the internet has a huge articles and you can get + +136 +00:10:05,080 --> 00:10:08,590 +benefit of them, we don't mind to use them يعني ال + +137 +00:10:08,590 --> 00:10:11,570 +internet متوفر فيه كثير من المقالات العلمية والكذا + +138 +00:10:11,570 --> 00:10:16,970 +ال student عادة إيش بيسووا؟ الطلاب و بيروحوا + +139 +00:10:16,970 --> 00:10:19,910 +بيسووا كما لو كانوا بتسألوا إيش بيحكي الأستاذ + +140 +00:10:19,910 --> 00:10:21,650 +مثلا على behavioral finance okay this is + +141 +00:10:21,650 --> 00:10:27,430 +behavioral finance behavioral + +142 +00:10:27,430 --> 00:10:31,710 +finance tick okay وشوفوا لهم أي شيء ب behavioral + +143 +00:10:31,710 --> 00:10:35,960 +finance أه بيعملوا copy و paste and this is the + +144 +00:10:35,960 --> 00:10:43,740 +assignment طبعا يعني خلينا نشوف اه ونيح + +145 +00:10:43,740 --> 00:10:51,460 +إذا بترجمه يكون كويس okay مثلا هاي + +146 +00:10:51,460 --> 00:10:54,020 +أه + +147 +00:11:02,260 --> 00:11:07,140 +Okay يعني شوفوا إيش بيصير، هاي هدول البنات مثلا + +148 +00:11:07,140 --> 00:11:10,320 +شوفوا إيش راح يسوي أو الشباب يعني، هياخدوا هذا ال + +149 +00:11:10,320 --> 00:11:12,840 +behavioral finance و هذا is يعني هذا الكلام اللي + +150 +00:11:12,840 --> 00:11:16,420 +شوفته يعني و ال .. الشباب و البنات اللي أنا كنت + +151 +00:11:16,420 --> 00:11:18,660 +أصلح لهم ال assignment بتاعهم you know they know + +152 +00:11:18,660 --> 00:11:22,700 +this بعرفوا الكلام هذا because I have a particular + +153 +00:11:22,700 --> 00:11:27,040 +software في عندنا software can easily address from + +154 +00:11:27,040 --> 00:11:30,040 +where you get your assignment يعني في عندنا + +155 +00:11:30,040 --> 00:11:32,900 +software بيقدر بسهولة إنه يعرف من وين أنتو جايبين + +156 +00:11:32,900 --> 00:11:36,640 +ال assignments بتاعتكم so and and the reader the + +157 +00:11:36,640 --> 00:11:39,740 +reader as well has a good experience to know from + +158 +00:11:39,740 --> 00:11:45,380 +where you get your assignments شوفوا باشا فاللي + +159 +00:11:45,380 --> 00:11:50,620 +صار إنه هدول هاي أخدنا copy and paste هو خلصنا طيب + +160 +00:11:50,620 --> 00:11:54,500 +أنا سهل جدا إنه أنا أقدر أعرف من وين جبتوا الكلام + +161 +00:11:54,500 --> 00:12:00,380 +هذا مجرد ما أنا في بعض ال documents مجرد ما أحط + +162 +00:12:00,380 --> 00:12:03,420 +إشارة على ال .. هذا بيمكن يجيب لي ال link ع طول + +163 +00:12:03,420 --> 00:12:09,780 +okay ال hyperlink بيجيب لي ال hyperlink from where + +164 +00:12:09,780 --> 00:12:13,910 +you get your assignments okay يعني إذا كان عندي وقت + +165 +00:12:13,910 --> 00:12:16,810 +بشوف ب .. ب .. ب أوريكوا كيف ال .. الاشي ممكن يصير + +166 +00:12:16,810 --> 00:12:21,990 +ف .. so be .. be careful فهو راحوا .. راح .. راح + +167 +00:12:21,990 --> 00:12:26,210 +.. أخدنا copy و بس فاللا بنروح كمان .. كمان إيش؟ + +168 +00:12:26,210 --> 00:12:31,410 +هيساو .. هنروح .. okay أخدنا هذا الكلام ماقرأناهوش + +169 +00:12:31,410 --> 00:12:34,610 +أكيد ماقرأناهوش لأن just we want to rush our + +170 +00:12:34,610 --> 00:12:37,830 +assignment you know what rush our assignment يعني + +171 +00:12:37,830 --> 00:12:40,550 +بس بدنا نمشي و نقول للأستاذ تبعنا اتفضل هي ال + +172 +00:12:40,550 --> 00:12:46,220 +assignment تبعنا that's it okay فما قرأنا هوه روحنا + +173 +00:12:46,220 --> 00:12:50,640 +كمان حكينا على ال .. ال .. شوفنا كمان موضوع ال + +174 +00:12:50,640 --> 00:12:55,140 +behavioral finance okay و خلصنا ال site الأول و + +175 +00:12:55,140 --> 00:13:01,200 +روحنا على ال site الثاني okay هذا هو فروحنا نفس + +176 +00:13:01,200 --> 00:13:06,060 +الشغل هيك هذا .. هذا فعلا أنا وجدته عند ال .. و + +177 +00:13:06,060 --> 00:13:10,200 +أنا في التصطيح يعني فروحنا عشان سوينا برضه نفس + +178 +00:13:10,200 --> 00:13:15,140 +الفيلم هيك طلعوافهذا there is no coherence هذا + +179 +00:13:15,140 --> 00:13:19,160 +مافيش فيه coherence مافيش فيه ترابط فعارفين زي إيش + +180 +00:13:19,160 --> 00:13:24,900 +عاملين زي الطبيخ الشحاتين بالظبط عارفين بروح بشحت + +181 +00:13:24,900 --> 00:13:29,760 +بياخد هذه خبزة هذه كذا هذه كذا بالاخير لما بروح + +182 +00:13:29,760 --> 00:13:32,860 +البيت بلاقي كل شيء موجود عنده لكن he or she + +183 +00:13:32,860 --> 00:13:37,200 +doesn't know how to mix between them بالاخير شغلات + +184 +00:13:37,200 --> 00:13:41,040 +مالهاش معنى بكل مكان و مش م .. يعني ممكن ال sweets + +185 +00:13:41,040 --> 00:13:46,860 +يكون مع الملوخية و ال .. أه بيمشي الحال فطبعا هذا + +186 +00:13:46,860 --> 00:13:51,140 +كمان نفس الشيء إنه إحنا بنقدر نعرف ال .. الكلام + +187 +00:13:51,140 --> 00:13:58,700 +هذا، تمام؟ فإحنا ال .. في ال website في هدول ال .. + +188 +00:13:58,700 --> 00:14:01,100 +ال .. ال internet إحنا ما بنعدد استخدام ال + +189 +00:14:01,100 --> 00:14:05,470 +internet بس في أصول استخدام ال net طيب، إيش هي + +190 +00:14:05,470 --> 00:14:07,990 +المصادر الموثوقة عشان أنا أحصل عليها المعلومات؟ + +191 +00:14:07,990 --> 00:14:11,090 +هاي المعلومات اللي موجودة في ال net أي واحد بحط أي + +192 +00:14:11,090 --> 00:14:15,490 +شيء وبالتالي ممكن تكون is not according to the + +193 +00:14:15,490 --> 00:14:19,150 +academic style فإيش هي ال website اللي إحنا بنعتمد + +194 +00:14:19,150 --> 00:14:23,050 +عليها؟ مثلا أول إيش عندنا اللي هو ال science + +195 +00:14:23,050 --> 00:14:29,850 +direct science direct www.sciencedirect + +196 +00:14:29,850 --> 00:14:30,990 +.com + +197 +00:14:35,800 --> 00:14:39,040 +Okay ال science .. ال science direct هذه هي + +198 +00:14:39,040 --> 00:14:44,820 +شايفينها أنتم أمامكم هذه يعني + +199 +00:14:44,820 --> 00:14:50,260 +credible و فيها articles articles يعني مقالات + +200 +00:14:50,260 --> 00:14:53,760 +علمية محكمة و فيها نتائج محكمة لو احنا كتبنا مثلا + +201 +00:14:53,760 --> 00:15:00,300 +على ال behavioral finance هيجيبنا + +202 +00:15:00,300 --> 00:15:03,900 +بال behavioral finance مثلا thousands of articles + +203 +00:15:05,020 --> 00:15:10,380 +شوفوا أنتو هنا عندكم articles في شيء منه purchase + +204 +00:15:10,380 --> 00:15:15,600 +و في منه free okay يعني مثلا هي شوفوا هذا كثير + +205 +00:15:15,600 --> 00:15:18,660 +مثلا behavioral finance and asset prices هي مقالة + +206 +00:15:18,660 --> 00:15:23,600 +علمية و is free okay يلا و احنا عملنا click عليها + +207 +00:15:23,600 --> 00:15:29,580 +هناخدها عشان احنا أنتو ما عندكوا مش هال experience + +208 +00:15:29,580 --> 00:15:33,400 +العالي جدا في إنه how to to get ممكن مقالة واحدة + +209 +00:15:33,400 --> 00:15:37,070 +تطلع للمقالات كثير بنشوف احنا هاي behavioral + +210 +00:15:37,070 --> 00:15:42,470 +finance ده بدناش نعمل لكم ال best هاي هم بيحفوا على + +211 +00:15:42,470 --> 00:15:46,530 +ال behavioral finance و هذا لما بال utility امبارح + +212 +00:15:46,530 --> 00:15:49,690 +لطلبة الدراسات اللي احنا شرحنا موضوع ال utility + +213 +00:15:49,690 --> 00:15:54,150 +هذا ال utility تمام مش شرط أنتو تفهموا كل شيء + +214 +00:15:54,150 --> 00:15:58,490 +موجود بال .. إيش تقرأوا في المقارن العلمية نقرأ ال + +215 +00:15:58,490 --> 00:16:02,720 +introduction و ال conclusion بس شوفوا هال .. هنرتب + +216 +00:16:02,720 --> 00:16:05,200 +ال idea ال introduction و ال conclusion هم + +217 +00:16:05,200 --> 00:16:07,700 +بيساعدوكم ان أنتو تفهموا هل المقالة بتعنيكم ولا + +218 +00:16:07,700 --> 00:16:12,840 +بتعنيكم مش هلأ أي مقالة علمية محكمة any academic + +219 +00:16:12,840 --> 00:16:18,540 +writing okay any article بيكون فيه معتمدة على + +220 +00:16:18,540 --> 00:16:22,400 +references فانت you don't need to waste your time + +221 +00:16:22,400 --> 00:16:25,440 +in looking for the references because the + +222 +00:16:25,440 --> 00:16:29,380 +references are already in the article يعني بترجعوا + +223 +00:16:29,380 --> 00:16:31,560 +هنا على ال references بتروح على ال references + +224 +00:16:31,560 --> 00:16:38,640 +بتعرفوا هذا المقالة عايش انبنت منروح نرجع هنا على + +225 +00:16:38,640 --> 00:16:44,600 +ال references هاي كل ال references موجودة مستحيل + +226 +00:16:44,600 --> 00:16:47,660 +إنه تنتشر مقالة علمية بال science direct خدوا + +227 +00:16:47,660 --> 00:16:52,160 +بالكم هذا بهذا الموقع الموقع هذا مستحيل تنتشر أي + +228 +00:16:52,160 --> 00:16:58,980 +مقالة علمية إلا تكون professional one كل فكرة بتنحط + +229 +00:16:58,980 --> 00:17:04,500 +ببساطة من أين أنت جبت الفكرة هاي، تمام؟ فروحنا + +230 +00:17:04,500 --> 00:17:06,460 +شايفين أنتو ال references، لو أنا أنزل ال video + +231 +00:17:06,460 --> 00:17:09,340 +app تشوفوها، يعني لو أخدنا نظرة على ال .. على ال + +232 +00:17:09,340 --> 00:17:09,660 +.. + +233 +00:17:43,540 --> 00:17:49,640 +Okay طبعا هذا واحد من ال .. واحد من ال .. قبل ما + +234 +00:17:49,640 --> 00:17:54,840 +ينزل ال website هنشوف إيش ال references اللي + +235 +00:17:54,840 --> 00:18:00,040 +متوفرة لو أخدنا هيك نظرة بسيطة على ال references + +236 +00:18:03,980 --> 00:18:11,500 +اكتبوا الموقع هذا ال science direct خلينا + +237 +00:18:11,500 --> 00:18:15,600 +نشوف .. + +238 +00:18:15,600 --> 00:18:20,820 +نشوف ال references ناخد نظرة على ال references + +239 +00:18:20,820 --> 00:18:25,180 +هدول و بنشوف مين ال references اللي فيها direct + +240 +00:18:25,180 --> 00:18:27,720 +بتحكي عن behavioral finance ممكن مش كل ال + +241 +00:18:27,720 --> 00:18:30,830 +references بتنزلم بس هيك يعني I think you just + +242 +00:18:30,830 --> 00:18:33,110 +need five minutes to look at the references اقرؤه + +243 +00:18:33,110 --> 00:18:35,810 +العناوين مثلا ليجي أول واحد بيحكي American + +244 +00:18:35,810 --> 00:18:38,810 +econometric أو بيسموه okay an exploration of the + +245 +00:18:38,810 --> 00:18:42,930 +effect of business okay ما نلزمنهاش الثاني + +246 +00:18:42,930 --> 00:18:47,950 +ما نلزمنهاش هيك بتكون تحكوا a simple model of هذا ال + +247 +00:18:47,950 --> 00:18:51,390 +behavior هذا مهم مثلا هذا a simple .. hard + +248 +00:18:51,390 --> 00:18:55,790 +behavior هذا بال .. بال ال behavioral finance hard + +249 +00:18:55,790 --> 00:18:59,530 +behavior إن المستثمرين لما واحد بيشتري بتلاقي الكل + +250 +00:18:59,530 --> 00:19:03,830 +اللي بيشتري معاه هذا بيسموه سياسة القطيع اه سياسة + +251 +00:19:03,830 --> 00:19:08,470 +القطيع فهي هذا مقال حلو كثير فبروحاش ممكن ناخده + +252 +00:19:08,470 --> 00:19:11,750 +okay بنعمل عليه click أو تكتبيه على هيك على دفتر و + +253 +00:19:11,750 --> 00:19:14,290 +.. شوفوا احنا من مقال واحد هنكتب ال assignment + +254 +00:19:14,290 --> 00:19:18,710 +سبعنا كله مقالة واحدة بس وهي هتساعدنا أن نجيب كل + +255 +00:19:18,710 --> 00:19:24,190 +المقالات المرتبطة فيها يعني لو وجدنا مثلا واحد بروح + +256 +00:19:24,190 --> 00:19:27,890 +ناخد هيك نطلع كمان هو barbari's et al prospect + +257 +00:19:27,890 --> 00:19:32,970 +theory and asset price this is important a model of + +258 +00:19:32,970 --> 00:19:36,430 +the investment sentiment investment sentiment يعني + +259 +00:19:36,430 --> 00:19:40,150 +معناها ال investor behavior this is important فممكن + +260 +00:19:40,150 --> 00:19:44,870 +نحطه هاي صار عندي three articles ثلاث مقالات بتبقى + +261 +00:19:44,870 --> 00:19:49,170 +لنا كمان ندور قبل أن .. على الأقل هنجدلنا ثلاث أربع + +262 +00:19:49,170 --> 00:19:54,010 +مقالات تمام؟ مثلا هاي the value of information + +263 +00:19:54,010 --> 00:19:57,510 +when preferences are dynamically inconsistent فكده + +264 +00:19:57,510 --> 00:19:59,870 +لما حكينا أنه احنا ال behavioral finance تعتمد على + +265 +00:19:59,870 --> 00:20:04,010 +ال public information فهي هاي مقال بحكي عن ال + +266 +00:20:04,010 --> 00:20:11,770 +information وهكذا طبعا فهذا مقال .. مقال واحد بس + +267 +00:20:11,770 --> 00:20:15,250 +حكينا في ال .. أو ثلاث أربع مقالات طلعناهم بس من + +268 +00:20:15,250 --> 00:20:18,130 +مقال واحد من behavioral finance هاي مثلا market + +269 +00:20:18,130 --> 00:20:20,490 +efficiency فاكرين لما احنا حكينا market efficiency + +270 +00:20:20,490 --> 00:20:25,530 +هذا أهم شوفوا فاهمة لما .. فا .. يجين فاهمة هذا + +271 +00:20:25,530 --> 00:20:28,730 +أهم واحد كتب بال .. بال behavioral finance يعني + +272 +00:20:28,730 --> 00:20:31,370 +هاي market efficiency فاكرين لما احنا تناقض market + +273 +00:20:31,370 --> 00:20:33,770 +efficiency وال long term returns وال behavioral + +274 +00:20:33,770 --> 00:20:39,330 +finance هذا this is d'accord هذا الأساس أي واحد لما + +275 +00:20:39,330 --> 00:20:43,190 +أنا بقى أصلح ال assignments سبعكم إذا ما لاجيتش + +276 +00:20:43,190 --> 00:20:48,470 +أجين وفاهمة .. أجين فاهمة بقول إنه مش .. مش كثير ال + +277 +00:20:48,470 --> 00:20:53,250 +.. ال assignments تمام؟ مش .. مش كثير ال + +278 +00:20:53,250 --> 00:20:57,730 +assignments ففي key .. key article .. key people + +279 +00:20:57,730 --> 00:21:03,860 +لازم نعرفهم لما إحنا نحكي في أي موضوع بأي موضوع + +280 +00:21:03,860 --> 00:21:07,920 +يعني مثلا أنتو بتحكوا عن الإسلام مثلا حكينا كثير + +281 +00:21:07,920 --> 00:21:10,180 +و هذا و ماذاكرناش الرسول صلى الله عليه وسلم + +282 +00:21:10,180 --> 00:21:13,800 +ما بنفع؟ وإيش الفائدة يعني أنتو بتحكوا عن الإسلام + +283 +00:21:13,800 --> 00:21:19,400 +والمظبوط ولا لأ؟ أو حكينا مثلا أهمية الصيام ولا + +284 +00:21:19,400 --> 00:21:22,980 +جيبنا آية كريمة ولا جيبنا قرآن كريم ولا جيبنا حديث + +285 +00:21:22,980 --> 00:21:27,940 +ولا جيبنا أي شيء ف .. فاحنا بنيجي في المقالات + +286 +00:21:27,940 --> 00:21:32,470 +العلمية لما نيجي نحكي عن ال behavioral finance مثلا + +287 +00:21:32,470 --> 00:21:39,410 +أهم ناس اللي هو أوجينه فامع فامع فامع أهم واحد كتب + +288 +00:21:39,410 --> 00:21:45,030 +بال behavioral finance فبدنا احنا لازم نعرف ال key + +289 +00:21:45,030 --> 00:21:45,410 +people + +290 +00:21:48,640 --> 00:21:52,880 +من هم الأشخاص الرئيسيين طبعا كيف ممكن احنا نعرف ال + +291 +00:21:52,880 --> 00:21:57,040 +key people هذول هاي سهلة جدا يعني لو احنا أخدنا + +292 +00:21:57,040 --> 00:22:04,140 +المقال سبع FAMA market + +293 +00:22:04,140 --> 00:22:12,360 +efficiency + +294 +00:22:12,360 --> 00:22:17,470 +فهو أهم واحد بيحكي عن ما هو market efficiency حكينا + +295 +00:22:17,470 --> 00:22:21,710 +أولا science direct سجلته شغل ثاني أنه احنا ممكن + +296 +00:22:21,710 --> 00:22:24,630 +نعتمد عليها ال google scholar ال google إيش + +297 +00:22:24,630 --> 00:22:28,470 +scholar مش ال google العادي لأن ال google + +298 +00:22:28,470 --> 00:22:31,530 +scholar هو بس بحط المقالات العلمية ما يحطش الربش + +299 +00:22:31,530 --> 00:22:38,190 +okay طبعا + +300 +00:22:38,190 --> 00:22:42,090 +كيف احنا بنسأل ال google scholar تروحوا scholar + +301 +00:22:42,090 --> 00:22:47,830 +وتحطوا scholar هيك و تروحوا google وهنا وصلنا ل + +302 +00:22:47,830 --> 00:22:57,850 +جوجل مثلا بدنا موضوع بال behavioral finance أيوة + +303 +00:22:57,850 --> 00:23:01,810 +اتطلعوني بالله أنا كيف .. كيف بدي أعرف أنا أن هذا + +304 +00:23:01,810 --> 00:23:08,130 +مقال مهم ولا مش مهم؟ مين بعرف؟ أول واحد كيف .. كيف + +305 +00:23:08,130 --> 00:23:10,830 +بعرف؟ مش شرط تكون أول واحد okay صح كرامتك أول واحد + +306 +00:23:10,830 --> 00:23:15,870 +بس في شغل أهم من أول واحد يعني أنا مثلا أخدت فاكرين + +307 +00:23:15,870 --> 00:23:19,930 +احنا أخدنا في ال .. اخترنا مقال من ال science + +308 +00:23:19,930 --> 00:23:25,460 +direct طلعنا عليهمو اخترنا أربع خمس مقالات بس بدي + +309 +00:23:25,460 --> 00:23:28,820 +أنا أعرف مين أهم واحد فيهم بروح على google scholar + +310 +00:23:28,820 --> 00:23:33,500 +google scholar بساعدني كثير عشان أعرف مين المهم و + +311 +00:23:33,500 --> 00:23:37,080 +ممكن ال science direct كمان بيساعدني اتطلعوا في ال + +312 +00:23:37,080 --> 00:23:39,140 +science direct اتطلعوا على ال science direct + +313 +00:23:39,140 --> 00:23:45,840 +انتبهوا هنا إيش مكتوب هنا cited by 827 عملوا cite + +314 +00:23:45,840 --> 00:23:50,180 +127 127 okay إيش يعني cite يعني كم واحد معتمد على + +315 +00:23:50,180 --> 00:23:54,870 +هذه الورقة ماخذ عليها 127 طب لو جينا لغير واحد + +316 +00:23:54,870 --> 00:24:00,110 +تسعين مش كثير طب ما 127 هذا أكثر واحد هذا اتناش مش + +317 +00:24:00,110 --> 00:24:04,850 +كثير هذا سبعة مش كثير اتناش إذا لحالنا هنعرف أن + +318 +00:24:04,850 --> 00:24:10,530 +أهم واحد هو هذا أكثر اعتماد أكثر اعتماد و + +319 +00:24:10,530 --> 00:24:15,270 +الأربعمية وين عندك أربعمية ها؟ وين؟ 800 ما احنا + +320 +00:24:15,270 --> 00:24:20,130 +حكينا فيه okay أخذناها على .. أخذناها على ال .. + +321 +00:24:20,130 --> 00:24:23,910 +على google scholar scholar هنا وكم واحد عمله + +322 +00:24:23,910 --> 00:24:28,130 +citation 3448 + +323 +00:24:28,130 --> 00:24:35,350 +يعني 3448 مقالة علمية اعتمدت على هذا المقالة و + +324 +00:24:35,350 --> 00:24:39,870 +حضرتنا احنا ما بدناش يعني ناخد منه حضرتنا يعني احنا + +325 +00:24:39,870 --> 00:24:44,220 +في ال assignment سبقنا الأول نقطة اللي حكينا فيها + +326 +00:24:44,220 --> 00:24:46,980 +ال coherence الثاني النقطة اللي بنحكي فيها ال + +327 +00:24:46,980 --> 00:24:49,240 +reference تبعتنا مين هي ال reference not any + +328 +00:24:49,240 --> 00:24:54,640 +reference وبتشوف شباب وبنات حاطين لش اسمه ال + +329 +00:24:54,640 --> 00:24:59,380 +link i don't need to see the link ال link ما بديش + +330 +00:24:59,380 --> 00:25:05,920 +أشوف وجه ال link نهائي بدي اشوف لو كتاب اكتبين أو + +331 +00:25:05,920 --> 00:25:09,160 +مقالة مقالتين بيكون بكفيني أنا ما ألزمنيش أكثر من + +332 +00:25:09,160 --> 00:25:14,940 +هيك تمام؟ طيب الو احنا أخذنا ال behavioral finance + +333 +00:25:14,940 --> 00:25:19,820 +هذا ال article + +334 +00:25:19,820 --> 00:25:23,680 +هاي + +335 +00:25:23,680 --> 00:25:31,680 +direct و ننزله عندنا و ننزله PDF ونقرأه هذا اللي + +336 +00:25:31,680 --> 00:25:36,440 +احنا ممكن نشترل عليه طب كيف احنا نعمل ال + +337 +00:25:36,440 --> 00:25:41,550 +reference؟ ال reference كيف نعمله أنا جهزتلكم مقالة + +338 +00:25:41,550 --> 00:25:44,710 +علمية عاملة references في many styles to do + +339 +00:25:44,710 --> 00:25:49,510 +references كثير styles بتعمل references ال + +340 +00:25:49,510 --> 00:25:55,690 +references إذا كان في داخل المقال بختلف عن ما هو + +341 +00:25:55,690 --> 00:26:02,810 +في ال references فلو احنا طلعنا هنا على المقالة + +342 +00:26:02,810 --> 00:26:06,450 +هذه المكتوبة هتشوفوا + +343 +00:26:11,200 --> 00:26:13,860 +لو شوفنا ال document map ضروري أن تكون عندكوا + +344 +00:26:13,860 --> 00:26:17,020 +document map زي هذه أنا هورّجيكوا كيف ممكن نعملها + +345 +00:26:17,020 --> 00:26:21,540 +شايفين ال document map على الشمال okay هذه يعني + +346 +00:26:21,540 --> 00:26:25,200 +أنا سهل جدا أروح access أروح أي موضوع فنروح على ال + +347 +00:26:25,200 --> 00:26:28,160 +references إذا موجودة عندنا هي ال references ال + +348 +00:26:28,160 --> 00:26:31,500 +references هي هذه موجودة في نهاية ال .. في نهاية + +349 +00:26:31,500 --> 00:26:38,180 +ال article هي مثلا اسم العابدي واحد اسمه عابدي و + +350 +00:26:38,180 --> 00:26:44,110 +hitch طبعا هذا style Harvard يعني بنكتب الاسم ال + +351 +00:26:44,110 --> 00:26:50,570 +family بعدين الحرف الأول من اسمه ممكن طبعا في ناس + +352 +00:26:50,570 --> 00:26:55,070 +بكتبوا الاسم كامل أنا ما عنديش مشكلة بعدين زي ما + +353 +00:26:55,070 --> 00:27:02,650 +تشايفين السنة بعدين بنكتب اسم المقالة كاملة بعدين + +354 +00:27:02,650 --> 00:27:07,470 +من المكان النشر تبعها تمام؟ من وين ممكن نحصل + +355 +00:27:07,470 --> 00:27:13,010 +عليها؟ هي كمان واحد bands اسم المقال journal + +356 +00:27:13,010 --> 00:27:18,530 +انتشرت فيها ال issue وال edition وال pages ثلاثة + +357 +00:27:18,530 --> 00:27:23,850 +لتمنتاش يعني هذه من ثلاثة لتمنتاش صفحة تمام فهذا + +358 +00:27:23,850 --> 00:27:29,250 +بيساعدكم هذا إذا كان في نهاية ال reference لو احنا + +359 +00:27:29,250 --> 00:27:33,470 +بدنا نعرف كيف نعمل reference في في المحتوى نفسه + +360 +00:27:33,470 --> 00:27:40,130 +تطلعوا يعني أنا بدأ أكبرلكم الخط شوية أساس تشوفوا + +361 +00:27:42,340 --> 00:27:47,800 +control شوفوا الخطك بده يكبر شوية بيكبر اه okay سهل + +362 +00:27:47,800 --> 00:27:55,700 +الشوفوا Banz مثلا شايفين Banz Banz 1981 has done + +363 +00:27:55,700 --> 00:27:59,980 +research in this field his study يعني دراسته حكت + +364 +00:27:59,980 --> 00:28:04,520 +واحد ثانيين ثلاثة أربعة خمسة طب بنشوف غير Banz طب + +365 +00:28:04,520 --> 00:28:08,840 +إذا كان أكثر من واحد نشوف كيف أكثر من واحد هنجد + +366 +00:28:08,840 --> 00:28:14,650 +أكثر من واحد طبعا إذا كنا بنحكي في بداية الجملة أو + +367 +00:28:14,650 --> 00:28:17,890 +في وسط الجملة لو احنا بنعمل reference بداية الجملة + +368 +00:28:17,890 --> 00:28:22,990 +أو وسط الجملة بنقول مثلا فلان فلاني حكى behavior + +369 +00:28:22,990 --> 00:28:24,710 +of finance هي هي هي هي هي هي هي هي هي هي هي هي + +370 +00:28:24,710 --> 00:28:24,750 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +371 +00:28:24,750 --> 00:28:26,250 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +372 +00:28:26,250 --> 00:28:28,970 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +373 +00:28:28,970 --> 00:28:32,390 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +374 +00:28:32,390 --> 00:28:32,450 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +375 +00:28:32,450 --> 00:28:36,490 +هي هي هي هي هي هي هي + +376 +00:28:36,490 --> 00:28:43,430 +هي هي هيفاصلة ألف وتسعمية وتسعين وبتسكر هذا إذا + +377 +00:28:43,430 --> 00:28:46,730 +كانت في نهاية الجملة حكينا كلامه وبعدين هذا + +378 +00:28:46,730 --> 00:28:49,810 +الكلام لمين الحكاه؟ bands ممكن أنا في عندي + +379 +00:28:49,810 --> 00:28:52,670 +تاريختين أنا أعمل reference لـ bands أقول bands + +380 +00:28:52,670 --> 00:28:56,950 +nineteen ninety says blah blah blah أو أكتب شو + +381 +00:28:56,950 --> 00:29:00,090 +حكاه وبعدين تحت اللي هو أكتب الـ .. اللي هو bands + +382 +00:29:00,090 --> 00:29:07,520 +اللي حكى الكلام لـ هذا في styles بتختلف بس احنا الـ + +383 +00:29:07,520 --> 00:29:13,480 +styles اللي نحكي الـ high quality style okay بعتمد + +384 +00:29:13,480 --> 00:29:17,080 +الطريقة اللي أنا بحكي فيها طبعًا يعني هنا مثلًا + +385 +00:29:17,080 --> 00:29:20,620 +bands بتنتهي في نهاية الجملة وطبعًا بدها يكونوا إن + +386 +00:29:20,620 --> 00:29:25,800 +أنتم تكونوا عندكم اللغة اللي تساعدكم مثلًا أنا + +387 +00:29:25,800 --> 00:29:34,370 +حكيت bands 1990 claims that blah blah blah طب راح + +388 +00:29:34,370 --> 00:29:39,790 +واحد ثاني غير bands مثلًا فإما فإما طبعًا نقطة وإذا + +389 +00:29:39,790 --> 00:29:48,870 +كانت نفس الحكي فنروح نكمل فإما 1996 for instance + +390 +00:29:48,870 --> 00:29:54,510 +argues فشوفوا أنا استخدمت claim واستخدمت argues + +391 +00:29:54,510 --> 00:29:59,410 +فمش حلو كثير أستخدم claims claims claims أنا أستخدم + +392 +00:29:59,410 --> 00:30:05,390 +نفس المصطلحات يعني بالعربي مثلًا فإما بيقول.. يقول + +393 +00:30:05,390 --> 00:30:12,430 +أن الـ behavioral finance كذا كذا كذا فإما يعرف.. + +394 +00:30:12,430 --> 00:30:16,290 +شوفوا استخدمنا كلمة أخرى بحيث إنه يصير في عندكم + +395 +00:30:16,290 --> 00:30:20,690 +يعني you are digesting the language إنه احنا عملنا + +396 +00:30:20,690 --> 00:30:24,160 +digesting لإن احنا بتشربوا اللغة مظبوط مش just لو + +397 +00:30:24,160 --> 00:30:28,880 +احنا نكرر the same things هذا إذا كان واحد اللي + +398 +00:30:28,880 --> 00:30:34,060 +كاتب الـ .. إذا كان أكثر من واحد هندور على أكثر من + +399 +00:30:34,060 --> 00:30:39,660 +واحد كاتبيه مثلًا الـ .. شوفوا هاي مثلًا Foster and + +400 +00:30:39,660 --> 00:30:44,560 +Stein طلعوا كيف Foster and Stein كيف.. كيف + +401 +00:30:44,560 --> 00:30:52,160 +معقولها references هي شايفين؟ Foster and Stein 2003 + +402 +00:30:52,160 --> 00:30:55,640 +studied the incremental added value of the meaning + +403 +00:30:55,640 --> 00:31:00,480 +-reverting trading strategies okay they هه طبعًا + +404 +00:31:00,480 --> 00:31:03,440 +مين they؟ ترجع لمين they؟ بالضبط مش أعيدهم كمرة + +405 +00:31:03,440 --> 00:31:10,620 +they ها Foster and كذا okay فهذا ايش الـ .. how to + +406 +00:31:10,620 --> 00:31:14,820 +do the references بتلاحظوا لو احنا جينا لكل.. + +407 +00:31:15,600 --> 00:31:19,440 +paragraph من هدول الـ paragraph اللي نجد إنه الـ + +408 +00:31:19,440 --> 00:31:24,220 +references كثيرة إذا كان تبقى إذا كان عندنا + +409 +00:31:24,220 --> 00:31:28,440 +two articles اثنين two writers طب لو كانوا ثلاثة + +410 +00:31:28,440 --> 00:31:34,900 +أو أكثر مين بيعرف كيف نعمل لهم نجيب لكم يلا مين + +411 +00:31:34,900 --> 00:31:44,640 +others طب بالانجليزي ايش نحكي اه طلعت..طلعوا إذا + +412 +00:31:44,640 --> 00:31:48,780 +كان أكثر من واحد إذا + +413 +00:31:48,780 --> 00:31:54,840 +كان أكثر من واحد بنحكي ايش et al et al معناه + +414 +00:31:54,840 --> 00:32:02,400 +وآخرون et al et al et al et al لحظة..ان شوه et al + +415 +00:32:02,400 --> 00:32:04,360 +نقطة 2004 + +416 +00:32:07,610 --> 00:32:10,670 +شفتوا كيف؟ يعني أنا أوريتكم لو كان reference + +417 +00:32:10,670 --> 00:32:14,310 +لواحد لو كان reference لاثنين لو كان reference + +418 +00:32:14,310 --> 00:32:20,550 +لثلاثة okay فإذا كان واحد is fine two are fine but + +419 +00:32:20,550 --> 00:32:25,310 +three more than three so you have to include اتقال + +420 +00:32:25,310 --> 00:32:31,330 +زي ما هي اتقال لكن بالـ reference تبعنا بالـ + +421 +00:32:31,330 --> 00:32:35,470 +reference تبعنا كلهم لانحطهم يعني لو احنا جبنا + +422 +00:32:35,470 --> 00:32:42,240 +تشوة نشوف et al هذا الرجال لو روحنا دورنا عليه بالـ + +423 +00:32:42,240 --> 00:32:47,860 +reference هنروح على الـ reference ونعرف et al CH + +424 +00:32:47,860 --> 00:32:52,060 +هاي + +425 +00:32:52,060 --> 00:33:02,320 +et al شوفت et al؟ كيف نعمله reference et al + +426 +00:33:02,320 --> 00:33:04,880 +et al + +427 +00:33:08,230 --> 00:33:14,080 +هو الاسم طبعًا هذا اسمه مختصر اسم الـ name سابقا هذا + +428 +00:33:14,080 --> 00:33:16,820 +بيكون الـ family name هذا بيكون الـ .. الـ fast name + +429 +00:33:16,820 --> 00:33:24,400 +تبعه وهذا K و W و.. ورمزها Maui و K طبعًا هدول + +430 +00:33:24,400 --> 00:33:27,900 +مبينين يا Japanese يا Chinese يا إما يابانيين يا + +431 +00:33:27,900 --> 00:33:32,380 +.. هنعرف من وين profiteering trading mechanisms و + +432 +00:33:32,380 --> 00:33:38,680 +الـ .. okay trading strategies طبعًا فهذا ايش et al + +433 +00:33:43,750 --> 00:33:47,930 +إذا عرفنا لو كان واحد لو كان اثنين لو كان ثلاثة + +434 +00:33:47,930 --> 00:33:50,430 +فهمنا إذا هي النقطة الثانية حكينا على الـ + +435 +00:33:50,430 --> 00:33:55,790 +coherence وحكينا على الـ references طبعًا إذا بشوف + +436 +00:33:55,790 --> 00:33:59,730 +أنا references مش كثيرة you are not follow this + +437 +00:33:59,730 --> 00:34:04,750 +style مع الكلام it may influence on your mark ممكن + +438 +00:34:04,750 --> 00:34:13,130 +تأثر على الدرجة تبعكم طبعًا؟ so be careful in.. in + +439 +00:34:13,130 --> 00:34:23,210 +doing this طيب من وين؟ من وين ممكن تجيب المجلة؟ + +440 +00:34:23,210 --> 00:34:25,370 +إذا أخذته واش من هنا، من وين ممكن تجيبه؟ من + +441 +00:34:25,370 --> 00:34:28,150 +المكتب، مش ممكن.. مش أنت عارف أنا أخذه من المكتب؟ + +442 +00:34:28,150 --> 00:34:36,610 +ممكن، و الله هيبقون نور على نور بقى.. إيه؟ والله + +443 +00:34:36,610 --> 00:34:45,130 +أنا خبرتي بتقول إنه يعني.. يعني مثلًا واحد عنده + +444 +00:34:45,130 --> 00:34:50,450 +مئة دونم أرض بده يزرعهم تمام؟ + +445 +00:34:50,450 --> 00:34:55,730 +أمامة خيارين يجيب هال بالدوزر هذا وبثواني يعمل + +446 +00:34:55,730 --> 00:34:59,410 +هالمئة دونم أو بدقائق أو يروح يمسك الفأس ويبدأ + +447 +00:34:59,410 --> 00:35:03,750 +يشتغل فيهم واحد واحد فالـ .. الـ .. المكتبة أصلًا ما + +448 +00:35:03,750 --> 00:35:08,010 +هي موجودة هنا المكتبة كلها وخاصة إذا الجامعة + +449 +00:35:08,010 --> 00:35:10,690 +الإسلامية في إلها access يلاحظوا هنا لما احنا + +450 +00:35:10,690 --> 00:35:13,030 +روحنا على google scholar أو على الـ science direct + +451 +00:35:13,030 --> 00:35:17,650 +نتبهوا في ملاحظة مهمة لازم تتبهوا إلها اطلعوا ع + +452 +00:35:17,650 --> 00:35:21,530 +أيديكم اليمين مكتوب ع أيديكم اليمين brought to + +453 +00:35:21,530 --> 00:35:24,630 +you Islamic university of Gaza الجامعة الإسلامية + +454 +00:35:24,630 --> 00:35:28,310 +مش تركية في هذا الـ .. في هذا الـ science direct + +455 +00:35:28,310 --> 00:35:32,210 +فمعناه كلها ممكن تروح على المكتبة ما تجدوش المقالة + +456 +00:35:32,210 --> 00:35:40,520 +بس تجدوها موجودة هنا فهمتي كيف؟ عادي فانتبهوا + +457 +00:35:40,520 --> 00:35:45,340 +للكلام اللي ممكن تروح على المكتب لكن مش كل شيء + +458 +00:35:45,340 --> 00:35:51,660 +موجود طبعًا وخاصة اليوم بالثورة التكنولوجية يعني + +459 +00:35:51,660 --> 00:36:00,780 +يعني أنا مثلًا بآخر ست سنوات بالمجال الأكاديمي تبعي + +460 +00:36:00,780 --> 00:36:04,940 +أو بالمجال الـ research صحيح كنا نجلس في المكتبة لكن + +461 +00:36:04,940 --> 00:36:09,360 +ما نستخدمش الـ .. الـ .. الـ hard copy ما نستخدمش الـ + +462 +00:36:09,360 --> 00:36:12,540 +hard copy نستخدم soft copy يعني احنا نعمل access + +463 +00:36:12,540 --> 00:36:16,700 +من المكتبة لأنه في جو مريح وفي هدوء وفي كذا و + +464 +00:36:16,700 --> 00:36:19,080 +إذا عجبنا الـ article نعمله printing out في المكتبة + +465 +00:36:19,080 --> 00:36:22,100 +ونقرأه في المكتبة هالمكتبة وجدت عشان احنا نعمل + +466 +00:36:22,100 --> 00:36:25,740 +focus وفي بعض الـ facilities ما بنستخدمهاش إلا + +467 +00:36:25,740 --> 00:36:30,910 +داخل المكتبة وخاصة بعض الـ database لو احنا طلعنا + +468 +00:36:30,910 --> 00:36:33,030 +برا المكتب مش هتكون احنا مسموح إلينا خاصة + +469 +00:36:33,030 --> 00:36:36,730 +electronic database خدمات إلكترونية مش هنقدر + +470 +00:36:36,730 --> 00:36:39,970 +نعملها access خارج المكتب بتكون داخل المكتب okay + +471 +00:36:39,970 --> 00:36:49,330 +طيب إذا حكينا عن الـ structure of writing استخدموا + +472 +00:36:49,330 --> 00:36:53,070 +كمان ممكن تستخدم footnotes يعني حكينا عن الـ + +473 +00:36:53,070 --> 00:36:56,050 +coherence حكينا عن الـ references نحكي عن الـ + +474 +00:36:56,050 --> 00:36:59,990 +footnotes ايش يعني الـ footnotes أنا امبارح اجاني + +475 +00:36:59,990 --> 00:37:06,070 +شاب وجاب لي المقال سبعه الـ assignments فإيش مكتوب + +476 +00:37:06,070 --> 00:37:14,130 +في الـ assignments مكتوب بلا بلا بلا I O U أو خلينا + +477 +00:37:14,130 --> 00:37:16,250 +نحكي إنه مثلًا on R + +478 +00:37:23,100 --> 00:37:27,420 +OE مثلًا return on equity في طبعًا احنا عندنا + +479 +00:37:27,420 --> 00:37:30,400 +طريقتين ممكن نتعامل مع الـ .. مع الـ abbreviations + +480 +00:37:30,400 --> 00:37:34,360 +هذه الطريقة الأولى أول مرة بتكتب الـ return on + +481 +00:37:34,360 --> 00:37:40,820 +equity أول مرة تكتب return on equity okay return + +482 +00:37:40,820 --> 00:37:46,220 +on equity خلاص بعد هيك بتصير تحط ROE هل الشاب لأ + +483 +00:37:46,220 --> 00:37:49,020 +عمل هيك ولا ايش؟ خلاص حاطط هيك فانا بسأله ايش هذا + +484 +00:37:49,020 --> 00:37:52,580 +بقول ما بعرفش طب.. طب what it means بابا؟ أنا + +485 +00:37:52,580 --> 00:37:56,240 +ما بعرفش، don't tell me I don't know because it is + +486 +00:37:56,240 --> 00:38:00,860 +your responsibility in every word that you write، + +487 +00:38:00,860 --> 00:38:03,700 +مسؤوليتها في كل كلمة أنت كاتبها otherwise somebody + +488 +00:38:03,700 --> 00:38:07,780 +else do the assignment الحل الآخر إنه ناس ثانيين + +489 +00:38:07,780 --> 00:38:10,560 +عملوا لك الـ assignment، so I intentionally ask him, + +490 +00:38:10,640 --> 00:38:12,640 +he said I don't know, I said okay take your + +491 +00:38:12,640 --> 00:38:14,960 +assignment and when you know deliver your + +492 +00:38:14,960 --> 00:38:19,360 +assignment خد الأصانع تبعك وكل ما تعرف ابعت لي + +493 +00:38:19,360 --> 00:38:29,160 +فإيش الشاب عامل IOU هتطها طب okay what it means he + +494 +00:38:29,160 --> 00:38:35,460 +keeps silence فإما to for instance investments, + +495 +00:38:36,140 --> 00:38:41,120 +utility, opportunity and utilities for instance + +496 +00:38:41,120 --> 00:38:43,950 +this is the abbreviations you either put it like + +497 +00:38:43,950 --> 00:38:48,730 +this or do like footnotes use the footnotes ايش الـ + +498 +00:38:48,730 --> 00:38:53,270 +footnotes الـ footnotes اللي احنا التعريفة هذه + +499 +00:38:53,270 --> 00:39:00,950 +نحطها في الهامش تحت هنوريكم إياها لو + +500 +00:39:00,950 --> 00:39:09,830 +شفنا احنا هاي الـ assignments okay + +501 +00:39:09,830 --> 00:39:11,350 +اطلعوا على الـ assignments هنا + +502 +00:39:14,770 --> 00:39:21,210 +هنجد في somewhere أنه الرجل مستخدم footnotes + +503 +00:39:21,210 --> 00:39:26,650 +اطلعوا + +504 +00:39:26,650 --> 00:39:33,890 +هنا شايفين طبعًا هو معرف sigma شوفوا هنا رقم اللي + +505 +00:39:33,890 --> 00:39:38,290 +هي رقم أربعة شايفينها هنا الصغيرة شايفينها Sigma + +506 +00:39:38,290 --> 00:39:42,770 +يعني واحدة من هالبنات ولا من هالولاد راح كاتب لي + +507 +00:39:42,770 --> 00:39:48,050 +we can measure the financial risk by using sigma + +508 +00:39:48,050 --> 00:39:53,810 +it was fine do you know what it means sigma I + +509 +00:39:53,810 --> 00:39:57,550 +don't know so if you don't know please don't write + +510 +00:39:57,550 --> 00:40:04,460 +it unless you understand it تكتبليش أي شيء مش فاهمه + +511 +00:40:04,460 --> 00:40:08,420 +يعني أنا في one of the prestigious students واحد + +512 +00:40:08,420 --> 00:40:10,240 +من الـ prestigious students you know what it means + +513 +00:40:10,240 --> 00:40:13,620 +prestigious students واحد منه وكان الطالب طبعًا + +514 +00:40:13,620 --> 00:40:19,380 +كاتب شغلة فأنا قلت لها don't show me your stupidity + +515 +00:40:19,380 --> 00:40:23,160 +ما تورجليش قد إيش أنت غبي why؟ + +516 +00:40:24,730 --> 00:40:28,690 +هي كاتبة شغلة I know she doesn't understand what + +517 +00:40:28,690 --> 00:40:32,230 +it means حاولي just write things that you + +518 +00:40:32,230 --> 00:40:35,890 +understand + +519 +00:40:35,890 --> 00:40:39,210 +اكتفوا بالشغلة بس اللي بتفهموها الشغلة اللي ما + +520 +00:40:39,210 --> 00:40:43,170 +بتفهموهاش وما تورجونيهاش يداش هذا الأستاذ تبعي مرة + +521 +00:40:43,170 --> 00:40:47,470 +كتبت شغلة أنا فاهمها في رأسي كنت أو حتى يمكن + +522 +00:40:47,470 --> 00:40:50,770 +ما كنتش فاهمها لو بقول لي well I will advise you one + +523 +00:40:50,770 --> 00:40:55,860 +thing show me how you are smart don't show me how + +524 +00:40:55,860 --> 00:41:00,820 +you are stupid آه و أرجيني كده أنت شاطر ما تورجيني + +525 +00:41:00,820 --> 00:41:05,040 +كده أنت غبي طبعًا كيف اكتشف شغلة أعمل شغل أنا + +526 +00:41:05,040 --> 00:41:10,020 +ما أخذها من واحد وأنا مش عارفها أنا يعني just + +527 +00:41:10,020 --> 00:41:13,700 +stuffing يعني أنا بحكي about myself أنا بحكي على + +528 +00:41:13,700 --> 00:41:20,160 +نفسي So try to avoid في طبعًا كل إنسان احنا ما احنا + +529 +00:41:20,160 --> 00:41:25,180 +وصلنا من درجة العلم أنه نحكي درجة الكمال لأ كل + +530 +00:41:25,180 --> 00:41:30,980 +إنسان في عنده أشياء لا يعرف فيها الشغليات اللي أنت + +531 +00:41:30,980 --> 00:41:36,090 +ما بتعرف فيها ما تكتبها unless أن أنت you recession + +532 +00:41:36,090 --> 00:41:39,670 +it, understand it and then put it in your .. لأن + +533 +00:41:39,670 --> 00:41:42,670 +واحد راح أنت نشرت المقال وواحد سألك اتصل فيك + +534 +00:41:42,670 --> 00:41:45,750 +تليفون جاك طب okay أنت عامل الشغل هذه وأنا مش + +535 +00:41:45,750 --> 00:41:54,170 +فاهمها ممكن تفهم ليها؟ إيش بيصير؟ تمام؟ + +536 +00:41:55,830 --> 00:42:01,090 +مرة أنا كتبت على موضوع .. موضوع بالـ .. بالـ .. بشغل + +537 +00:42:01,090 --> 00:42:06,090 +اسمه الـ .. بالـ finance فواحد في جامعة university + +538 +00:42:06,090 --> 00:42:13,510 +of .. نسيت الجامعة في Warwick فبيستشر أستاذه أخد الـ + +539 +00:42:13,510 --> 00:42:16,450 +email تبعه وهذا وبعت الـ email قال can I call + +540 +00:42:16,450 --> 00:42:19,480 +you okay واتصل فيه تليفون وقال لي أنا في الـ + +541 +00:42:19,480 --> 00:42:24,180 +equation هذه بالـ leads and lags أنا يعني حاولت + +542 +00:42:24,180 --> 00:42:26,940 +أطبقها بالستاتة ومش واضحة عندي ممكن يعني تساعدني + +543 +00:42:26,940 --> 00:42:31,160 +أشتري free time وكذا فتصوروا أن أنا حاطط شغلة مش + +544 +00:42:31,160 --> 00:42:38,480 +عارف كيف معمولة بيصيب بمشكلة ولا لأ؟ okay so try to + +545 +00:42:38,480 --> 00:42:40,980 +.. any things include in your assignment to + +546 +00:42:40,980 --> 00:42:43,740 +understand it you don't need to read things that + +547 +00:42:43,740 --> 00:42:47,680 +you don't understand تمام؟ فشوفنا الـ footnotes اللي + +548 +00:42:47,680 --> 00:42:52,440 +هو عندنا الـ sigma اللي انكتبت الـ sigma وعرفناها الـ + +549 +00:42:52,440 --> 00:42:58,940 +sigma اللي هي .. خلّيني أحكي control F بدنا sigma + +550 +00:42:58,940 --> 00:43:03,020 +شوفوا + +551 +00:43:03,020 --> 00:43:09,780 +هي sigma شايفينها sigma هنا؟ مكتوب and these extreme + +552 +00:43:09,780 --> 00:43:13,180 +values are not confined three sigmas طب احنا + +553 +00:43:13,180 --> 00:43:18,650 +حكيتها three sigmas شو هم الـ three sigmas هدول؟ we + +554 +00:43:18,650 --> 00:43:22,270 +don't know يعني even me I don't know so explain + +555 +00:43:22,270 --> 00:43:26,550 +this فبنحط في الـ footnote ستة okay sigma is a + +556 +00:43:26,550 --> 00:43:30,050 +standard deviation about ninety nine point seven + +557 +00:43:30,050 --> 00:43:34,190 +percent of a normal distribution m zero one is + +558 +00:43:34,190 --> 00:43:39,270 +confined to three sigmas خلاص وضحت عرفت what it + +559 +00:43:39,270 --> 00:43:45,710 +means sigma الطريقة الثانية أن احنا بتعملي sigma + +560 +00:43:45,710 --> 00:43:51,620 +طريقة ثانية sigma وبتعمل between quotation و + +561 +00:43:51,620 --> 00:43:57,780 +بتروحي بتحطيها بانجوسان that's it ممكن نحط الـ + +562 +00:43:57,780 --> 00:44:07,220 +abbreviations + +563 +00:44:07,220 --> 00:44:11,700 +ونحط الـ sigma هذه كلها فهمش الحال طب إذا في كان + +564 +00:44:11,700 --> 00:44:14,660 +أكثر من تعريف لـ sigma ممكن نحط sigma ونقول other + +565 +00:44:14,660 --> 00:44:19,750 +people explain sigma like this Okay فأنتبهنا للـ + +566 +00:44:19,750 --> 00:44:23,390 +footnotes how you can use the footnotes يعني بيكون + +567 +00:44:23,390 --> 00:44:31,330 +بيكون مرات strange concept strange concept مصطلحات + +568 +00:44:31,330 --> 00:44:39,070 +غريبة وخاصة ممكن مصطلحات لاتينية okay يعني مثلًا + +569 +00:44:39,070 --> 00:44:42,210 +لما نحكي عن random walk okay random walk what it + +570 +00:44:42,210 --> 00:44:45,810 +means فلازم يكون عندنا وضوح فيها طيب + +571 +00:44:49,600 --> 00:44:54,700 +فالأول صفحة عندنا بنات هي أول صفحة أنا بدأ أكتب الـ + +572 +00:44:54,700 --> 00:44:59,280 +assignment تبعي الـ assignment تبعي أول صفحة بتكتب + +573 +00:44:59,280 --> 00:45:02,480 +فيها التفاصيل تبعتكم زي ما هي موجودة هنا تلعبوا + +574 +00:45:02,480 --> 00:45:10,320 +التفاصيل خليكي أحسن التفاصيل + +575 +00:45:10,320 --> 00:45:15,660 +اسم السؤال اللي أنتم هتتعاملوا عليه تمام واسمكم + +576 +00:45:15,660 --> 00:45:20,020 +أنتم تمام وأي فصل اللي بعدين بيصير عندي الـ table + +577 +00:45:20,020 --> 00:45:23,220 +of contents خلصنا أول صفحة في الصفحة الثانية إيش + +578 +00:45:23,220 --> 00:45:29,800 +بعمل الـ table of contents الـ table of contents + +579 +00:45:29,800 --> 00:45:34,340 +يعني جدول المحتويات جدول المحتويات بنعمله بآخر شيء + +580 +00:45:34,340 --> 00:45:39,240 +طيب وأنا هأرجيكم كمان كيف ممكن نسوي بنتركنا + +581 +00:45:39,240 --> 00:45:42,540 +صفحتان أول ما بنسوي بنكتب شغلة اسمه introduction + +582 +00:45:42,540 --> 00:45:44,760 +المقدمة + +583 +00:45:45,900 --> 00:45:50,300 +صفحة الثالثة هاي الـ introduction الـ introduction + +584 +00:45:50,300 --> 00:45:54,960 +بتاخد heading one بتاخد إيش heading one يعني بتاخد + +585 +00:45:54,960 --> 00:45:58,460 +العنوان الرئيسي فعشان بتاخد heading one بنروح على + +586 +00:45:58,460 --> 00:46:04,740 +شايفين هنا heading one هاي heading one طبعًا تنسوش + +587 +00:46:04,740 --> 00:46:11,900 +أن أنتم تعملوا ترقيم للصفحات تنسوش طبعًا هاي عملنا + +588 +00:46:11,900 --> 00:46:16,560 +ترقيم للصفحات بنرجع للصفحة رقم اثنين ارجعوا على + +589 +00:46:16,560 --> 00:46:21,300 +صفحة 2 وبنحط اللي هو الـ table of contents صفحة + +590 +00:46:21,300 --> 00:46:29,680 +الثانية بنروح نحكي reference تمام وبنروح شايفين + +591 +00:46:29,680 --> 00:46:33,000 +الـ table of contents وبنعمل click عليه نختار أي + +592 +00:46:33,000 --> 00:46:36,220 +style احنا بعجبنا ونروح ونقوله okay فهي كتبت الـ + +593 +00:46:36,220 --> 00:46:42,060 +introduction صفحة 3 شايفينها يعني ما بديش أنا أكتب + +594 +00:46:42,950 --> 00:46:46,610 +يعني manual خلاص automatically هلأ إيش الموضوع أنا + +595 +00:46:46,610 --> 00:46:49,770 +كتبنا بالـ introduction يعني كتبنا الـ introduction + +596 +00:46:49,770 --> 00:46:52,490 +الـ introduction إيش بدنا نكتب فيها الـ introduction + +597 +00:46:52,490 --> 00:46:56,970 +بدك تكتب فيها what are you going to do إيش أنت + +598 +00:46:56,970 --> 00:47:04,930 +هتسوي بالراحة okay هلأ في الصفحة الثانية حكينا + +599 +00:47:04,930 --> 00:47:07,870 +الصفحة الأولى your details الصفحة الثانية بدنا + +600 +00:47:07,870 --> 00:47:10,790 +نحكي عن الـ table of contents بنروح على references + +601 +00:47:10,790 --> 00:47:11,690 +زي ما تشوفها + +602 +00:47:16,870 --> 00:47:23,590 +مش مشكلة بنروح على table of contents في عندك زي ما + +603 +00:47:23,590 --> 00:47:27,050 +أنت شايفه فيه many styles الـ styles اللي بيعجبكم + +604 +00:47:27,050 --> 00:47:33,190 +بيختاروه فبنروح عاش بنحط نعمل click بيجي لبعد نحن + +605 +00:47:33,190 --> 00:47:38,070 +نخلص كل الشغل تبعنا بس نعمل update field بس هيغير + +606 +00:47:38,070 --> 00:47:43,410 +وي .. طيب هلأ إيش الـ introduction إيش بتشمل؟ طبعًا + +607 +00:47:43,410 --> 00:47:46,210 +الـ introduction عادة تكتب آخر شيء لكن احنا بدنا + +608 +00:47:46,210 --> 00:47:49,430 +نكتبها بحيث نورجيكوا إيش الـ introduction what you + +609 +00:47:49,430 --> 00:47:53,890 +are going to do مثلًا + +610 +00:47:53,890 --> 00:48:00,770 +بنقول this assignment aims + +611 +00:48:00,770 --> 00:48:08,490 +to explain أول جملة هي أهم جملة أنتم بتحطوها أهم + +612 +00:48:08,490 --> 00:48:11,590 +جملة أن أنتم بتسوها this assignment aims to + +613 +00:48:11,590 --> 00:48:15,750 +explain the behavioral finance or the trading + +614 +00:48:15,750 --> 00:48:20,070 +mechanisms خلنا ناخد سؤال the trading mechanisms + +615 +00:48:20,070 --> 00:48:25,430 +أي سؤال بتكون إياه mechanisms and the market + +616 +00:48:25,430 --> 00:48:26,870 +participants + +617 +00:48:30,480 --> 00:48:35,680 +طيب هلأ احنا حطينا أول جملة هذه الـ key idea تبعتنا + +618 +00:48:35,680 --> 00:48:38,840 +طيب الـ training mechanisms what it means training + +619 +00:48:38,840 --> 00:48:41,320 +mechanisms فبنبدأ نكتب okay the training + +620 +00:48:41,320 --> 00:48:48,680 +mechanisms means + +621 +00:48:48,680 --> 00:48:52,580 +that وبتبدأ تعرفوا إيش الـ training mechanisms + +622 +00:48:52,580 --> 00:48:57,300 +خلصنا خلصنا الـ paragraph هذه بنروح بنحكي إيش + +623 +00:48:57,300 --> 00:49:00,340 +ضايقنا نحكي عن market participants the market + +624 +00:49:00,340 --> 00:49:04,260 +participants includes + +625 +00:49:04,260 --> 00:49:09,800 +okay وبتبدأ تحكي عن market participants خلصنا + +626 +00:49:09,800 --> 00:49:16,920 +بنجور this assignment is + +627 +00:49:16,920 --> 00:49:18,560 +structured as follows + +628 +00:49:23,250 --> 00:49:27,250 +ماذا يعني structured يعني منظم كالتالي section one + +629 +00:49:27,250 --> 00:49:29,290 +talk about this section two talk about this + +630 +00:49:29,290 --> 00:49:33,070 +section three and the conclusion خلصنا يعني البخرة + +631 +00:49:33,070 --> 00:49:37,550 +الـ introduction فاهم كل شي he or she doesn't need + +632 +00:49:37,550 --> 00:49:44,350 +to go to read your assignments هلأ نيجي نحكي نكمل + +633 +00:49:44,350 --> 00:49:47,730 +خلصنا الـ introduction نحكي section one مثلا اللي + +634 +00:49:47,730 --> 00:49:50,210 +هو behavioral or trading mechanisms + +635 +00:49:55,310 --> 00:49:59,610 +طبعا trading mechanisms كله ورا بعض الـ trading + +636 +00:49:59,610 --> 00:50:05,690 +mechanisms هذي هذي heading هذي head و هذي ايش head + +637 +00:50:05,690 --> 00:50:09,130 +بتاخد heading one تروحوا على heading one و اقبلها + +638 +00:50:09,130 --> 00:50:12,450 +heading لو احنا طلعنا فوق طلعنا فوق و عملنا + +639 +00:50:12,450 --> 00:50:19,330 +updates okay update للـ table update into our table + +640 +00:50:19,330 --> 00:50:25,470 +هنجد ان الـ trading mechanisms انتحطت Okay فاللأ + +641 +00:50:25,470 --> 00:50:29,810 +حكينا عن trading mechanisms لجينا أنه في trading + +642 +00:50:29,810 --> 00:50:35,110 +mechanisms عرفناها وحكينا فلان بيحكي trading + +643 +00:50:35,110 --> 00:50:40,410 +mechanism كذا و okay و .. و trading mechanism تشمل + +644 +00:50:40,410 --> 00:50:43,250 +عدة mechanisms لاحظين mechanisms يعني في كذا + +645 +00:50:43,250 --> 00:50:47,590 +mechanisms يعني مثلا ممكن نقول dealer market + +646 +00:50:50,590 --> 00:50:54,010 +طبعا ننساش ان احنا نرقم الـ introduction بتاخد رقم + +647 +00:50:54,010 --> 00:50:59,130 +واحد شفتوا الـ trading mechanism بتاخد رقم اتنين + +648 +00:50:59,130 --> 00:51:02,990 +اذا كان فرعي الـ dealer market بتاخد two point one + +649 +00:51:02,990 --> 00:51:08,390 +و بتاخد heading ايش heading two منروح على heading + +650 +00:51:08,390 --> 00:51:11,310 +one منروح على heading two لو احنا روحنا على الـ + +651 +00:51:11,310 --> 00:51:15,150 +table الموجود هنا نعمل update table هنلاقي انه + +652 +00:51:15,150 --> 00:51:19,650 +شوفوا كيف الترتيب صار heading one صار heading two + +653 +00:51:22,450 --> 00:51:26,910 +طبعا حكينا عن الـ dealer market و كذا بعدين روح + +654 +00:51:26,910 --> 00:51:33,890 +نقاش في mechanism تاني اللي هو مثلا الـ ACN's طبعا + +655 +00:51:33,890 --> 00:51:39,010 +الـ ACN's الـ electronic communication networks طبعا + +656 +00:51:39,010 --> 00:51:43,830 +بتاخد 2.2 مظبوط برضه بنعطيها heading 2 + +657 +00:51:48,320 --> 00:51:52,400 +لازم يكونوا متساوين يعني إذا أنت بتكتب في الـ + +658 +00:51:52,400 --> 00:51:56,180 +dealer market مثلا عشر أسطور هديك تقريبا مش شرط + +659 +00:51:56,180 --> 00:52:00,700 +تقريبا تسعة عشرة أو أحداشر أه اللي يكون فيه توازن + +660 +00:52:00,700 --> 00:52:04,950 +بال ..تقارب لو رجعنا كمان على هنا هنلاقي ايش + +661 +00:52:04,950 --> 00:52:10,470 +update و هنلاقي ايش 2.2 طيب خلصنا نحكي عن trading + +662 +00:52:10,470 --> 00:52:13,470 +mechanisms نروح نحكي عن اللي هو market + +663 +00:52:13,470 --> 00:52:16,610 +participants شوفتوا كيف احنا زي ما حكيت الـ main + +664 +00:52:16,610 --> 00:52:19,950 +ideas مرتبطة فيها مافيش اشي يعني مابنحكيش اشي برا + +665 +00:52:19,950 --> 00:52:25,570 +الموضوع نحكي مثلا على market participants market + +666 +00:52:25,570 --> 00:52:27,870 +participants + +667 +00:52:31,710 --> 00:52:40,090 +هذه هتاخد تلاتة صح هتاخد تلاتة هتاخد Heading 1 هاي + +668 +00:52:40,090 --> 00:52:46,470 +Heading 1 تمام Heading 1 حكينا عن الـ market .. + +669 +00:52:46,470 --> 00:52:48,730 +أعرفنا الـ market participants و أعرفنا مين هم + +670 +00:52:48,730 --> 00:52:51,990 +فنيجي نحكي الأنواع و مين هم الـ market participants + +671 +00:52:51,990 --> 00:52:56,890 +ممكن نقول مثلا الـ three نيجي نحكي اللي هو الـ + +672 +00:52:56,890 --> 00:52:57,230 +investors + +673 +00:53:00,560 --> 00:53:07,840 +مثلا و بنحكي عن الـ investors مثلا mutual funds و + +674 +00:53:07,840 --> 00:53:11,460 +بنحكي عن الـ mutual funds الـ investors بنحطها + +675 +00:53:11,460 --> 00:53:17,800 +heading 2 تمام و ها دي heading 2 تمام و ها دي + +676 +00:53:17,800 --> 00:53:25,800 +بتكون 3.1 و ها دي 3.2 okay + +677 +00:53:25,800 --> 00:53:35,280 +و جينا بنعمل update للـ table شوفوا كيف مرتب الاشي + +678 +00:53:35,280 --> 00:53:40,360 +هك شايفين كيف مرتب introduction ماضحة انا لما بطلع + +679 +00:53:40,360 --> 00:53:43,820 +الـ table of contents انا بقدر اقيم شغلك من اول + +680 +00:53:43,820 --> 00:53:47,660 +صفحة من اول صفحة اقدر اعرف you are you are doing + +681 +00:53:47,660 --> 00:53:51,400 +well ولا you are just rushing your assignments طب + +682 +00:53:51,400 --> 00:53:54,080 +انا هذا بس اذكركم انه انا هذا الـ assignment كان + +683 +00:53:54,080 --> 00:53:57,200 +مطلوب منكم من شهرين زمان صح او يعني about three + +684 +00:53:57,200 --> 00:54:05,150 +months من تلت شهورمش .. مش هذه المشكلة المشكلة أنه + +685 +00:54:05,150 --> 00:54:08,350 +لو أنت قرأت في دقيقة أقل شيء أنه كان عندك .. موجود + +686 +00:54:08,350 --> 00:54:13,290 +عندك شغلة تكتب فيها لأن الـ writing تيجي أخر إشي + +687 +00:54:13,290 --> 00:54:15,530 +أول شي بيكون فيه reading و بعدين بندخل على الـ + +688 +00:54:15,530 --> 00:54:18,170 +writing طبعا هذا الـ first step + +689 +00:54:21,240 --> 00:54:25,020 +فخلصنا بيصير انه احنا بدنا نشوف موضوعنا trading + +690 +00:54:25,020 --> 00:54:28,780 +mechanisms in Palestine Stock Exchange مش هيك + +691 +00:54:28,780 --> 00:54:32,940 +سؤالنا خلصنا market participants خلصنا كذا بالظبط + +692 +00:54:32,940 --> 00:54:35,960 +بعدين بيحكي على اللي هو بدنا نعرف ايش الـ trading + +693 +00:54:35,960 --> 00:54:38,600 +mechanisms اللي متعاملوا فيها مثلا Palestine Stock + +694 +00:54:38,600 --> 00:54:39,140 +Exchange + +695 +00:54:45,700 --> 00:54:52,400 +هذه Palestine Stock Exchange هتاخد heading one و رقم + +696 +00:54:52,400 --> 00:54:57,640 +تلاتة و رقم أربعة زي ما انتوا بتكونوا لإن هذه + +697 +00:54:57,640 --> 00:55:01,060 +هتكون ACN's + +698 +00:55:01,060 --> 00:55:02,940 +هنعمل control X + +699 +00:55:09,170 --> 00:55:12,090 +نفس الشغل هنحكي في Palestine Stock Exchange + +700 +00:55:12,090 --> 00:55:16,730 +موضوعين إيش هم الـ trading mechanisms اللي بتبقى و + +701 +00:55:16,730 --> 00:55:22,870 +market participants هيكون عندى 4.1 و 4.2 هنيجي + +702 +00:55:22,870 --> 00:55:32,370 +نعرف اللي هو BSC الـ trading mechanisms تمام + +703 +00:55:32,370 --> 00:55:36,770 +و عندنا اللي هو market participants بس هذا المطلوب + +704 +00:55:36,770 --> 00:55:37,090 +مننا + +705 +00:55:42,640 --> 00:55:49,020 +Okay فبنيجي هنا منروح + +706 +00:55:49,020 --> 00:55:53,440 +هنا طبعا heading heading 2 هذا heading 2 وهذا + +707 +00:55:53,440 --> 00:55:58,540 +heading 2 okay الأخر + +708 +00:55:58,540 --> 00:56:04,280 +إشي بعد ما خلصنا الكلام هذا نكتب الـ conclusion هاي + +709 +00:56:04,280 --> 00:56:07,460 +الـ conclusion رقم 5 بتاخد صح conclusion + +710 +00:56:10,830 --> 00:56:16,110 +Okay الـ conclusion نحطها heading ham و هرجع + +711 +00:56:16,110 --> 00:56:20,710 +أحكيلكوا إيش الـ conclusion بس الصبر يا باشا الـ + +712 +00:56:20,710 --> 00:56:23,790 +conclusion خلصنا الـ conclusion نحط إيش الـ + +713 +00:56:23,790 --> 00:56:28,950 +references الـ references و إذا كان في عندي + +714 +00:56:28,950 --> 00:56:32,470 +appendix بحط الـ appendix هاي الـ references و بنروح + +715 +00:56:32,470 --> 00:56:34,730 +نحط نعطيها heading طبعا ماترقموهاش الـ references + +716 +00:56:34,730 --> 00:56:39,110 +بتترقمش لإن هي مش جزء من الـ .. اه فلو روحنا احنا + +717 +00:56:39,110 --> 00:56:40,050 +عملنا updates + +718 +00:56:43,250 --> 00:56:47,050 +updates هاي هي الـ assignment تبعنا شايفينه يعني + +719 +00:56:47,050 --> 00:56:53,970 +نكمل لكم إياها شويه هيك شوفوا + +720 +00:56:53,970 --> 00:57:01,250 +كيف يعني professional هاي + +721 +00:57:01,250 --> 00:57:08,440 +إيش رأيكم يعني ممكن تصور جنبه احناأي introduction, + +722 +00:57:09,580 --> 00:57:12,640 +trading mechanisms, dealers و الـ conclusion نيجي + +723 +00:57:12,640 --> 00:57:16,620 +نحكي أخر شيء بعدين طلعوا يا بنات يا بنات انتبهوا + +724 +00:57:16,620 --> 00:57:22,600 +هان لو روحنا احنا على view روحنا على document map + +725 +00:57:22,600 --> 00:57:25,860 +هاي الـ document map تبعتنا فانا بدل ما أروح أدور + +726 +00:57:25,860 --> 00:57:28,580 +في الصفحة وين بدأ أروح بدأ أروح مثلا أقرأ في الـ + +727 +00:57:28,580 --> 00:57:31,280 +conclusion بروح بعمل tick على الـ conclusion و بروح + +728 +00:57:31,280 --> 00:57:37,620 +أشوفه طيب الـ conclusion إيش هي؟كيف نعملها؟ طيب، + +729 +00:57:37,620 --> 00:57:42,980 +هلأ بتروحي على view و بتروحي على view و بتحطي على + +730 +00:57:42,980 --> 00:57:47,020 +document map تحطي على document map و إيجدكي على + +731 +00:57:47,020 --> 00:57:52,480 +الشمال طبعا بالـ version تبع العشرة أجمل شوية + +732 +00:57:52,480 --> 00:57:55,980 +بيعطيكي document map بطريقة مرتبة و رائعة كتير + +733 +00:57:55,980 --> 00:58:00,630 +okay فالا بدك تروح مثلا على market participants + +734 +00:58:00,630 --> 00:58:03,790 +justic، بدك تروح على الـ conclusion justic on the + +735 +00:58:03,790 --> 00:58:07,730 +conclusion، أسهل يعني تصور إن عندك مثلا خمسمية + +736 +00:58:07,730 --> 00:58:10,250 +صفحة، بدك يبقى عندك خمسمية صفحة، بدك تروح على + +737 +00:58:10,250 --> 00:58:15,010 +خمسمية صفحة، okay؟ بعدين conclusion، الـ conclusion + +738 +00:58:15,010 --> 00:58:18,210 +إيش هي؟ هي الـ introduction لكن بتعملوها + +739 +00:58:18,210 --> 00:58:22,470 +paraphrase، that's it عملولها paraphrase يعني عيدوا + +740 +00:58:22,470 --> 00:58:27,990 +صياغة الـ introduction يعني ممكن انتوا اذا احنا + +741 +00:58:27,990 --> 00:58:31,110 +بدأنا من a to z يعني مثلا من الـ introduction + +742 +00:58:31,110 --> 00:58:36,050 +اقبلوا من z to a فهمتوا؟ بالعكس؟ اه اقبلوا بالعكس + +743 +00:58:36,050 --> 00:58:40,150 +يعني نفسها يعني تحكوش اشي بالـ conclusion انتوا + +744 +00:58:40,150 --> 00:58:49,290 +ماحكتوش عنه نهائي احكوا شغلات مكتوبة عنهاو الله ب + +745 +00:58:49,290 --> 00:58:52,690 +conclusion ناسقته و لكن الباحث يارا كذا كذا طب انت + +746 +00:58:52,690 --> 00:58:56,350 +حكيت في الكلام هذا داخل الـ lesson و ماحكيتش طبعا + +747 +00:58:56,350 --> 00:59:03,970 +فهذا اللي انا اللي هدب بسريع كيف احنا نكتب الـ + +748 +00:59:03,970 --> 00:59:08,950 +introduction و كيف نتعامل معها طبعا هذه احنا بنقول + +749 +00:59:08,950 --> 00:59:14,490 +مش كتير يعني تفصيلية لكن على الأقل على مستواكوا + +750 +00:59:14,490 --> 00:59:15,770 +يعني بتساعدكوا + +Okay, please provide the Arabic/English lecture transcript you would like me to review and correct. I will focus on typos and grammatical errors while maintaining the original language, dialect, and meaning of the text. I will only provide the corrected transcript in the same format as your input. diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/iRmUeYH3Y2Q_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/iRmUeYH3Y2Q_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..2a5aa67063877db1e8d26b6c7eb501ba6cd8d5dd --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/iRmUeYH3Y2Q_raw.srt @@ -0,0 +1,3012 @@ +1 +00:00:21,800 --> 00:00:25,040 +بسم الله الرحمن الرحيم اليوم زي ما احنا حكينا + +2 +00:00:25,040 --> 00:00:30,420 +معاكم المرة الفاتة انه كيف تكتبوا ال .. ال + +3 +00:00:30,420 --> 00:00:34,880 +assignments الواجب تبعكم فحنركز اليوم writing up + +4 +00:00:34,880 --> 00:00:37,600 +your university assignments كيف نكتب ال .. ال + +5 +00:00:37,600 --> 00:00:43,660 +university assignments تبعناها اه لأنه ال .. لما + +6 +00:00:43,660 --> 00:00:48,610 +احنا نعمل الواجب تبعناهاال .. ال .. ال reader يعني + +7 +00:00:48,610 --> 00:00:52,530 +ال .. الأستاذ تبعكم بده يقرأ ال .. ال .. الواجبات + +8 +00:00:52,530 --> 00:00:57,390 +ف هو he or she cannot put in the .. in the shelf + +9 +00:00:57,390 --> 00:01:03,260 +unless he is reading your workفهو لازم يقرأ ال .. + +10 +00:01:03,260 --> 00:01:08,700 +الشغل تبعكم فعشان احنا ناخد علامات منيحة في ال + +11 +00:01:08,700 --> 00:01:13,100 +assignment okay في .. we have to follow the + +12 +00:01:13,100 --> 00:01:16,920 +quality of assignments how to write the assignment + +13 +00:01:16,920 --> 00:01:23,800 +so I .. includes two main textbook how to write + +14 +00:01:23,800 --> 00:01:26,700 +the assignment هذا أول textbook زي ما أنتوا + +15 +00:01:26,700 --> 00:01:30,740 +شايفينه writing up your university assignmentOkay + +16 +00:01:30,740 --> 00:01:37,680 +هذا textbook is important مهم كتير بالشرط لل .. لل + +17 +00:01:37,680 --> 00:01:41,000 +investments هذا لأي إشي ممكن ت .. بكرا ما تعملوا + +18 +00:01:41,000 --> 00:01:47,180 +ال .. بحث التخرج مثلا بتكون بتعملوا مثلا لما + +19 +00:01:47,180 --> 00:01:49,940 +تطلعوا على شغلكم مثلا تروحوا تشتغلوا في مؤسسات how + +20 +00:01:49,940 --> 00:01:55,080 +to write a report كيف نكتب تقرير فكتير كويس ان + +21 +00:01:55,080 --> 00:01:58,700 +انتوا تاخدوا هذا ال .. هذا الكتاب و خاصة ان هذا + +22 +00:01:58,700 --> 00:02:08,180 +الكتاب يعنيموجود و يدرس في يعني في جامعات يعني + +23 +00:02:08,180 --> 00:02:11,400 +أخدت high quality في ال .. في ال writing okay + +24 +00:02:11,400 --> 00:02:15,480 +هناخد بس يعني مختصر عشان ايش الكتاب هذا يعني ايش + +25 +00:02:15,480 --> 00:02:19,880 +بيحكي قبل ما احنا ندخل في تفاصيل المحاضرة تبعتنا + +26 +00:02:19,880 --> 00:02:23,840 +اليوم طبعا بيحكي the fundamental of academic + +27 +00:02:23,840 --> 00:02:32,140 +writingأساسيات في ال academic writing okay بدنا .. + +28 +00:02:32,140 --> 00:02:35,280 +قبل ما نبدأ ال assignments أولا بدنا نعرف what is + +29 +00:02:35,280 --> 00:02:38,540 +the assignment about؟ إيش هو؟ عن إيش بيحكي ال + +30 +00:02:38,540 --> 00:02:40,580 +assignments؟ هل أنتوا بتعملوا analysis بال + +31 +00:02:40,580 --> 00:02:44,620 +assignments؟ ولا أنتوا just explain ideas؟ ولا + +32 +00:02:44,620 --> 00:02:49,760 +أنتوا بتحطوا ideas؟ هل هو descriptive؟ يعني وصفي؟ + +33 +00:02:49,760 --> 00:02:55,570 +توصفوا شغلة معينة؟ you are exploratory؟بتكتشفوا + +34 +00:02:55,570 --> 00:03:01,090 +شغلة معينة أو بتركزوا على مواضيع معينة ف .. بدنا + +35 +00:03:01,090 --> 00:03:04,210 +نعرف why we are using academic writing؟ ليش احنا + +36 +00:03:04,210 --> 00:03:08,150 +بنستخدم ال academic writing؟ يعني التقارير + +37 +00:03:08,150 --> 00:03:12,690 +الأكاديمية و الدراسات الأكاديمية، تمام؟ تاني شغلة + +38 +00:03:12,690 --> 00:03:17,870 +how should I structure my writing؟ كيف أنا أرتب ال + +39 +00:03:17,870 --> 00:03:21,870 +.. ال writing تبعي؟ أهم إشي في ال writing يكون في + +40 +00:03:21,870 --> 00:03:25,980 +عندي شغلة اسمها coherencecoherence إيش معناه + +41 +00:03:25,980 --> 00:03:29,780 +coherence تماسك يعني من أول الموضوع لآخر الموضوع + +42 +00:03:29,780 --> 00:03:35,720 +كله فيه ترابط يعني إحنا لو جينا مثلا هان عادة + +43 +00:03:35,720 --> 00:03:40,260 +بيكون في عنا the main idea بتاعة ال assignment هاي + +44 +00:03:40,260 --> 00:03:46,780 +ال main idea بعدين في ideas أخرى مرتبطة في ال main + +45 +00:03:46,780 --> 00:03:51,500 +ideas إحنا بتبدأ نتوسع في هذه ال ideasزي ما إنتوا + +46 +00:03:51,500 --> 00:03:57,100 +شايفين ف every part of the ideas is connected with + +47 +00:03:57,100 --> 00:04:02,340 +the main ideas كل جزء من ال .. ال .. الأفكار + +48 +00:04:02,340 --> 00:04:05,520 +الفرعية مرتبط بالفكرة الرئيسية فهذا بيسموه + +49 +00:04:05,520 --> 00:04:08,860 +coherence يكون في عنده ترابط يعني مثلا لما أنا + +50 +00:04:08,860 --> 00:04:12,860 +بحكي عن behavioral finance هو واحد من ال .. + +51 +00:04:12,860 --> 00:04:17,830 +الأسئلة اللي مطلوبة منكم behavioral financeفي ال + +52 +00:04:17,830 --> 00:04:21,790 +main idea I should define what is the .. the .. + +53 +00:04:21,790 --> 00:04:24,550 +the idea of behavioral finance شو هي behavioral + +54 +00:04:24,550 --> 00:04:28,910 +finance تمام؟ و all of these ideas are linked with + +55 +00:04:28,910 --> 00:04:34,870 +the main idea تمام؟ الكل بيكون مرتبط بال .. بال + +56 +00:04:34,870 --> 00:04:37,910 +main idea for instance the .. the behavioral + +57 +00:04:37,910 --> 00:04:44,990 +finance is considered the market is not efficient + +58 +00:04:44,990 --> 00:04:50,690 +for instanceOkay and you discuss this concept و + +59 +00:04:50,690 --> 00:04:55,090 +احنا بتبدأ نقش هذا ال concept within the other + +60 +00:04:55,090 --> 00:05:00,830 +ideas your eyes focusing on the main ideas and the + +61 +00:05:00,830 --> 00:05:04,150 +secondary ideas are related to the main idea يعني + +62 +00:05:04,150 --> 00:05:07,690 +بتكون الفكرة الفرعية مرتبطة بالفكرة الرئيسية هذا + +63 +00:05:07,690 --> 00:05:12,550 +بيسموه coherence بيسمي ايش? coherence تلعبت في بعض + +64 +00:05:12,550 --> 00:05:16,190 +الطلاب لما شوفنا ال assignments تبعتهم بيحكي + +65 +00:05:16,190 --> 00:05:19,710 +بموضوعو بعدين بنتخلع موضوع تاني و بعدين بنتخلع + +66 +00:05:19,710 --> 00:05:23,930 +موضوع تالت and so on مافيش .. لما نقرأ .. you are + +67 +00:05:23,930 --> 00:05:26,810 +like .. when you are reading your assignments you + +68 +00:05:26,810 --> 00:05:31,190 +are like narrating a story زي ما احنا بنحكي قصة + +69 +00:05:31,190 --> 00:05:34,730 +it's .. it has introduction, main body and the + +70 +00:05:34,730 --> 00:05:38,930 +conclusion if you mislead the reader in .. in your + +71 +00:05:38,930 --> 00:05:43,150 +writing style it means you don't have efficient + +72 +00:05:43,150 --> 00:05:46,800 +academic writingيعني إذا انتوا you are misleading + +73 +00:05:46,800 --> 00:05:51,880 +the .. the reader يعني .. يعني مابتواجهوش ال + +74 +00:05:51,880 --> 00:05:54,840 +reader صح معناه كلمة you mislead the reader + +75 +00:05:54,840 --> 00:05:59,220 +بالاخير مافيش quality مافيش efficiency so there is + +76 +00:05:59,220 --> 00:06:03,360 +no need for your reward يعني هلا مثلا لما بنروح + +77 +00:06:03,360 --> 00:06:06,600 +احنا نكتب reward about .. يعني و احنا صغار كانوا + +78 +00:06:06,600 --> 00:06:09,680 +يدرسونا أنه نكتب تقرير على أنه رحلة إلى البحر + +79 +00:06:09,680 --> 00:06:15,880 +بينفعش نروح والله اتغذينا في البحر و روحناSo it's + +80 +00:06:15,880 --> 00:06:19,640 +from the beginning starting the idea أنه رحلة إلى + +81 +00:06:19,640 --> 00:06:24,280 +البحر تمام و نبدأ ندخل فيه بعد ما فكرة الرحلة و + +82 +00:06:24,280 --> 00:06:27,300 +بعدين ندخل في التفاصيل و ال conclusion تماما طيب + +83 +00:06:27,300 --> 00:06:32,160 +فهذه أول .. أول chapter بحكي the .. the functions + +84 +00:06:32,160 --> 00:06:37,400 +of .. ثاني chapter هو ال structure بتاعة + +85 +00:06:37,400 --> 00:06:41,440 +ال thesis أو بتاعة ال academic writing حكينا على + +86 +00:06:41,440 --> 00:06:47,380 +ال coherence التماسكيعني كل جزء كبير بتماسك بال .. + +87 +00:06:47,380 --> 00:06:49,900 +بالجزء الكبير، يعني مثلا خلينا نحكي رحلة إلى + +88 +00:06:49,900 --> 00:06:55,440 +البحر، بنفعش مثلا في .. في رقم .. في فكرة من + +89 +00:06:55,440 --> 00:07:00,700 +الأفكار هان موجود و الله و اتفرجنا على فيلم و كان + +90 +00:07:00,700 --> 00:07:04,640 +كتير ممتع، طبعا هذا .. هذا مش في البحر صارis not + +91 +00:07:04,640 --> 00:07:08,060 +related. So why you are include this? Because some + +92 +00:07:08,060 --> 00:07:11,940 +people they want to stuff their writing. إيش + +93 +00:07:11,940 --> 00:07:17,080 +أستفف؟ يحشوا، في ناس بس بدهم يحشوا، بس بدهم يحكوا + +94 +00:07:17,080 --> 00:07:22,100 +أي إشي، و أنا أحكي أي إشي، we don't need this، + +95 +00:07:22,100 --> 00:07:27,040 +okay؟ يعني زي ما بيحكوا مقلة ودلدائما بيسألوا + +96 +00:07:27,040 --> 00:07:30,620 +بيقولوا لي ايش ال how many pages we can write + +97 +00:07:30,620 --> 00:07:36,520 +write as .. as much as you want اكتب جد ما بدك as + +98 +00:07:36,520 --> 00:07:41,340 +much as I understand جد ما انا افهم انه يعني you + +99 +00:07:41,340 --> 00:07:44,520 +conclude your ideas okay to the level that I + +100 +00:07:44,520 --> 00:07:48,260 +understand your writing فأول شي حكينا اذا ال + +101 +00:07:48,260 --> 00:07:53,360 +coherenceواضحة what it means coherence كله تماسك + +102 +00:07:53,360 --> 00:07:56,800 +okay يعني احنا بنحكي مثلا على ال .. the mechanisms + +103 +00:07:56,800 --> 00:08:01,420 +of .. of palestinian stock exchange or the trading + +104 +00:08:01,420 --> 00:08:03,560 +mechanisms in palestinian .. palestine stock + +105 +00:08:03,560 --> 00:08:07,740 +exchange يعني احنا بنحكي عن آلية التداول في سوق + +106 +00:08:07,740 --> 00:08:11,960 +فلسطين أوراق المالية okay the main idea is the + +107 +00:08:11,960 --> 00:08:16,140 +trading mechanisms you + +108 +00:08:16,140 --> 00:08:20,660 +are talking about trading mechanismsOkay so the + +109 +00:08:20,660 --> 00:08:23,500 +first question or I think this is the third + +110 +00:08:23,500 --> 00:08:26,380 +question in your assignment explain the trading + +111 +00:08:26,380 --> 00:08:31,260 +mechanisms and the market participants in your in + +112 +00:08:31,260 --> 00:08:34,660 +Palestine Stock Exchange So this assignment + +113 +00:08:34,660 --> 00:08:37,580 +includes two main ideas هذا بيشتمل two main ideas + +114 +00:08:37,580 --> 00:08:41,500 +the first one is the trading mechanisms okay the + +115 +00:08:41,500 --> 00:08:45,060 +second one is the market participants يعني trading + +116 +00:08:45,060 --> 00:08:49,950 +mechanisms يعني ألية التداول في وسوقو ال .. و ال + +117 +00:08:49,950 --> 00:08:54,050 +second idea is talking about the market + +118 +00:08:54,050 --> 00:08:57,770 +participants فلو أجينا احنا ال ideas هان هنقسمها + +119 +00:08:57,770 --> 00:09:02,090 +في اسمين هيكون القسم الأول trading mechanisms we + +120 +00:09:02,090 --> 00:09:04,750 +are talking about trading mechanisms and related + +121 +00:09:04,750 --> 00:09:07,950 +ideas و بعدين القسم التاني في عندنا second main + +122 +00:09:07,950 --> 00:09:11,610 +idea talking about market participants market + +123 +00:09:11,610 --> 00:09:16,040 +participantsخلينا نركز بس على هذا السؤال و نشوف + +124 +00:09:16,040 --> 00:09:18,740 +how we can deal with this question كيف ممكن احنا + +125 +00:09:18,740 --> 00:09:22,840 +نعالج هذا السؤال طيب ما زلنا نحكي عن ال structure + +126 +00:09:22,840 --> 00:09:26,320 +the structure of your academic writing حكينا عن ال + +127 +00:09:26,320 --> 00:09:28,880 +coherence الشغل التاني بال structure you have to + +128 +00:09:28,880 --> 00:09:33,840 +be careful with the referencing لازم تاخد بالك من + +129 +00:09:33,840 --> 00:09:38,900 +ال references avoid plagiarism what it means + +130 +00:09:38,900 --> 00:09:41,460 +plagiarism? plagiarism + +131 +00:09:45,140 --> 00:09:47,260 +plagiarism means أنه to copy and paste from + +132 +00:09:47,260 --> 00:09:49,640 +others, you claim this is your work and this is + +133 +00:09:49,640 --> 00:09:52,600 +not your work يعني أنت بتقول إن هذا شغلك و في + +134 +00:09:52,600 --> 00:09:58,260 +الواقع هذا مش شغلك, try to avoid plagiarism, here + +135 +00:09:58,260 --> 00:10:05,080 +the internet has a huge articles and you can get + +136 +00:10:05,080 --> 00:10:08,590 +benefit of themwe don't mind to use them يعني ال + +137 +00:10:08,590 --> 00:10:11,570 +internet متوفر فيه كتير من المقالات العلمية والكذا + +138 +00:10:11,570 --> 00:10:16,970 +ال student عادة إيش بيسويهوا الطلاب و بيروحوا + +139 +00:10:16,970 --> 00:10:19,910 +بيسويوا كما لو كانوا بتسألوا إيش بيحكي الأستاذ + +140 +00:10:19,910 --> 00:10:21,650 +مثلا على behavioral finance okay this is + +141 +00:10:21,650 --> 00:10:27,430 +behavioral finance behavioral + +142 +00:10:27,430 --> 00:10:31,710 +finance tick okay وشوفولهم أي إشي ب behavioral + +143 +00:10:31,710 --> 00:10:35,960 +financeأه بيعملوا copy و paste and this is the + +144 +00:10:35,960 --> 00:10:43,740 +assignment طبعا يعني خلينا نشوف اه ونيح + +145 +00:10:43,740 --> 00:10:51,460 +إذا بترجمه يكون كويس okay مثلا هاي + +146 +00:10:51,460 --> 00:10:54,020 +أه + +147 +00:11:02,260 --> 00:11:07,140 +Okay يعني شوفوا إيش بيصير هاي هدول البنات مثلا + +148 +00:11:07,140 --> 00:11:10,320 +شوفوا إيش راح يسوي أو الشباب يعني هياخدوا هذا ال + +149 +00:11:10,320 --> 00:11:12,840 +behavioral finance و هذا is يعني هذا الكلام اللي + +150 +00:11:12,840 --> 00:11:16,420 +شوفته يعني و ال .. الشباب و البنات اللي أنا كنت + +151 +00:11:16,420 --> 00:11:18,660 +أصلحهم ال assignment بتاعهم you know they know + +152 +00:11:18,660 --> 00:11:22,700 +this بعرفوا الكلام هذا because I have a particular + +153 +00:11:22,700 --> 00:11:27,040 +software في عندنا software can easily address from + +154 +00:11:27,040 --> 00:11:30,040 +where you get your assignmentيعني في عندنا + +155 +00:11:30,040 --> 00:11:32,900 +software بيقدر بسهولة انه يعرف من وين انتوا جايبين + +156 +00:11:32,900 --> 00:11:36,640 +ال assignments بتاعتكم so and and the reader the + +157 +00:11:36,640 --> 00:11:39,740 +reader as well has a good experience to know from + +158 +00:11:39,740 --> 00:11:45,380 +where you get your assignments شوفوا باشا فاللي + +159 +00:11:45,380 --> 00:11:50,620 +صار انه هدول هاي أخدنا copy and paste هو خلصنا طيب + +160 +00:11:50,620 --> 00:11:54,500 +انا سهل جدا انه انا اقدر اعرف من وين جبتوا الكلام + +161 +00:11:54,500 --> 00:12:00,380 +هذامجرد ما انا في بعض ال documents مجرد ما احط + +162 +00:12:00,380 --> 00:12:03,420 +اشارة على ال .. هذا بيمكن يجيبلي ال link ع طول + +163 +00:12:03,420 --> 00:12:09,780 +okay ال hyperlink بيجيبلي ال hyperlink from where + +164 +00:12:09,780 --> 00:12:13,910 +you get your assignments okayيعني إذا كان عندى وقت + +165 +00:12:13,910 --> 00:12:16,810 +بشوف ب .. ب .. بارجيكوا كيف ال .. الاشي ممكن يصير + +166 +00:12:16,810 --> 00:12:21,990 +ف .. so be .. be careful فهو راحوا .. راح .. راح + +167 +00:12:21,990 --> 00:12:26,210 +.. أخدنا copy و بس فاللا بنروح كمان .. كمان إيش؟ + +168 +00:12:26,210 --> 00:12:31,410 +هيساو .. هنروح .. okay أخدنا هذا الكلام ماقرأنهوش + +169 +00:12:31,410 --> 00:12:34,610 +أكيد ماقرأنهوش لأن just we want to rush our + +170 +00:12:34,610 --> 00:12:37,830 +assignment you know what rush our assignment يعني + +171 +00:12:37,830 --> 00:12:40,550 +بس بدنا نمشي و نقول للأستاذ تبعنا اتفضل هى ال + +172 +00:12:40,550 --> 00:12:46,220 +assignment تبعناthat's it okay فما قرأنا هوش روحنا + +173 +00:12:46,220 --> 00:12:50,640 +كمان حكينا على ال .. ال .. شوفنا كمان موضوع ال + +174 +00:12:50,640 --> 00:12:55,140 +behavioral finance okay و خلصنا ال site الأول و + +175 +00:12:55,140 --> 00:13:01,200 +روحنا على ال site التاني okay هذا هو فروحنا نفس + +176 +00:13:01,200 --> 00:13:06,060 +الشغل هيك هذا .. هذا فعلا انا وجدته عند ال .. و + +177 +00:13:06,060 --> 00:13:10,200 +انا في التصطيح يعني فروحنا عشان سوينا برضه نفس + +178 +00:13:10,200 --> 00:13:15,140 +الفيلم هيك طلعوافهذا there is no coherence هذا + +179 +00:13:15,140 --> 00:13:19,160 +مافيش فيه coherence مافيش فيه ترابط فعارفين زي إيش + +180 +00:13:19,160 --> 00:13:24,900 +عاملين زي الطبيخ الشحاتين بالظبط عارفين بروح بشحت + +181 +00:13:24,900 --> 00:13:29,760 +بياخد هذي خبزة هذي كذا هذي كذا بالاخير لما بروح + +182 +00:13:29,760 --> 00:13:32,860 +البيت بلاقي كل إشي موجود عنده لكن he or she + +183 +00:13:32,860 --> 00:13:37,200 +doesn't know how to mix between themبالاخير شغلات + +184 +00:13:37,200 --> 00:13:41,040 +مالهاش معنا بكل مكان و مش م .. يعني ممكن ال sweets + +185 +00:13:41,040 --> 00:13:46,860 +يكون مع الملوخية و ال .. أه بيمشي الحل فطبعا هذا + +186 +00:13:46,860 --> 00:13:51,140 +كمان نفس الشيء أنه إحنا بنقدر نعرف ال .. الكلام + +187 +00:13:51,140 --> 00:13:58,700 +هذا، تمام؟ فإحنا ال .. في ال website في هدول ال .. + +188 +00:13:58,700 --> 00:14:01,100 +ال .. ال internet إحنا ما بنعدد استخدام ال + +189 +00:14:01,100 --> 00:14:05,470 +internet بس في أصول استخدام ال netطيب، إيش هي + +190 +00:14:05,470 --> 00:14:07,990 +المصادر الموثوقة عشان أنا أحصل عليها المعلومات؟ + +191 +00:14:07,990 --> 00:14:11,090 +هاي المعلومات اللي موجودة في ال net أي واحد بحط أي + +192 +00:14:11,090 --> 00:14:15,490 +إشي وبالتالي ممكن تكون is not according to the + +193 +00:14:15,490 --> 00:14:19,150 +academic style فإيش هي ال website اللي إحنا بنعتمد + +194 +00:14:19,150 --> 00:14:23,050 +عليها؟ مثلا أول إيش عندنا اللي هو ال science + +195 +00:14:23,050 --> 00:14:29,850 +direct science direct www.sciencedirect + +196 +00:14:29,850 --> 00:14:30,990 +.com + +197 +00:14:35,800 --> 00:14:39,040 +Okay ال science .. ال science direct هذه هي + +198 +00:14:39,040 --> 00:14:44,820 +شايفينها أنتم أمامكم هذه يعني + +199 +00:14:44,820 --> 00:14:50,260 +credible و فيها articles articles يعني مقالات + +200 +00:14:50,260 --> 00:14:53,760 +علمية محكمة و فيها نتائج محكمة لو احنا كتبنا مثلا + +201 +00:14:53,760 --> 00:15:00,300 +على ال behavioral finance هيجيبنا + +202 +00:15:00,300 --> 00:15:03,900 +بال behavioral finance مثلا thousands of articles + +203 +00:15:05,020 --> 00:15:10,380 +شوفوا انتوا هنا عندكم articles فى إشي منه purchase + +204 +00:15:10,380 --> 00:15:15,600 +و فى منه free okay يعني مثلا هى شوفوا هذا كتير + +205 +00:15:15,600 --> 00:15:18,660 +مثلا behavioral finance and asset prices هى مقالة + +206 +00:15:18,660 --> 00:15:23,600 +علمية و is free okay يالا و احنا عملنا click عليها + +207 +00:15:23,600 --> 00:15:29,580 +هناخدها عشان احنا انتوا ماعندكوا مش هال experience + +208 +00:15:29,580 --> 00:15:33,400 +العالى جدا فى انه how to to get ممكن مقالة واحدة + +209 +00:15:33,400 --> 00:15:37,070 +تطلع للمقالات كتيربنشوف احنا هاي behavioral + +210 +00:15:37,070 --> 00:15:42,470 +finance ده بدناش نعملكوا ال best هاي هم بيحفوا على + +211 +00:15:42,470 --> 00:15:46,530 +ال behavioral finance و هذا لما بال utility امبارح + +212 +00:15:46,530 --> 00:15:49,690 +لطلبة الدراسات اللي احنا شرحنا موضوع ال utility + +213 +00:15:49,690 --> 00:15:54,150 +هذا ال utility تمام مش شرط انتوا تفهموا كل شي + +214 +00:15:54,150 --> 00:15:58,490 +موجود بال .. ايش تقرأوا في المقارن العلمية نقرأ ال + +215 +00:15:58,490 --> 00:16:02,720 +introduction و ال conclusion بسشوفوا هال .. هنرتب + +216 +00:16:02,720 --> 00:16:05,200 +ال idea ال introduction و ال conclusion هم + +217 +00:16:05,200 --> 00:16:07,700 +بيساعدوكوا ان انتوا تفهموا هل المقالة بتعنيكوا ولا + +218 +00:16:07,700 --> 00:16:12,840 +بتعنيكو مش هلأ اي مقالة علمية محكمة any academic + +219 +00:16:12,840 --> 00:16:18,540 +writing okay any article بيكون فيه معتمدة على + +220 +00:16:18,540 --> 00:16:22,400 +references فانت you don't need to waste your time + +221 +00:16:22,400 --> 00:16:25,440 +in looking for the references because the + +222 +00:16:25,440 --> 00:16:29,380 +references are already in the articleيعني بترجعوا + +223 +00:16:29,380 --> 00:16:31,560 +هنا على ال references بتروح على ال references + +224 +00:16:31,560 --> 00:16:38,640 +بتعرفوا هذا المقالة عايش انبنت منروح نرجع هنا على + +225 +00:16:38,640 --> 00:16:44,600 +ال references هاي كل ال references موجودة مستحيل + +226 +00:16:44,600 --> 00:16:47,660 +انه تنتشر مقالة علمية بال science direct خدوا + +227 +00:16:47,660 --> 00:16:52,160 +بالكم هذا بهذا الموقع الموقع هذا مستحيل تنتشر اي + +228 +00:16:52,160 --> 00:16:58,980 +مقالة علمية الا تكون professional oneكل فكرة بتنحط + +229 +00:16:58,980 --> 00:17:04,500 +ببساطة من أين أنت جبت الفكرة هاي، تمام؟ فروحنا + +230 +00:17:04,500 --> 00:17:06,460 +شايفين أنتوا ال references، لو أنا أنزل ال video + +231 +00:17:06,460 --> 00:17:09,340 +app تشوفوها، يعني لو أخدنا نظرة على ال .. على ال + +232 +00:17:09,340 --> 00:17:09,660 +.. + +233 +00:17:43,540 --> 00:17:49,640 +Okay طبعا هذا واحد من ال .. واحد من ال .. قبل ما + +234 +00:17:49,640 --> 00:17:54,840 +ينزل ال website هنشوف إيش ال references اللي + +235 +00:17:54,840 --> 00:18:00,040 +متوفرة لو أخدنا هيك نظرة بسيطة على ال references + +236 +00:18:03,980 --> 00:18:11,500 +اكتبوا الموقع هذا الو science direct خلينا + +237 +00:18:11,500 --> 00:18:15,600 +نشوف .. + +238 +00:18:15,600 --> 00:18:20,820 +نشوف ال references ناخد نظرة على ال references + +239 +00:18:20,820 --> 00:18:25,180 +هدول و بنشوف مين ال references اللي فيها direct + +240 +00:18:25,180 --> 00:18:27,720 +بتحكي عن behavioral finance ممكن مش كل ال + +241 +00:18:27,720 --> 00:18:30,830 +references بتنزمنابس هيك يعني I think you just + +242 +00:18:30,830 --> 00:18:33,110 +need five minutes to look at the references اقرؤه + +243 +00:18:33,110 --> 00:18:35,810 +العناوين مثلا ليجي اول واحد بيحكي American + +244 +00:18:35,810 --> 00:18:38,810 +econometric او بيسموه okay an exploration of the + +245 +00:18:38,810 --> 00:18:42,930 +effect of business okay مابلزمنهاش التاني + +246 +00:18:42,930 --> 00:18:47,950 +مابلزمنهاش هيك بتكون تحكواa simple model of هذا ال + +247 +00:18:47,950 --> 00:18:51,390 +behavior هذا مهم مثلا هذا a simple .. hard + +248 +00:18:51,390 --> 00:18:55,790 +behavior هذا بال .. بال ال behavioral finance hard + +249 +00:18:55,790 --> 00:18:59,530 +behavior ان المستثمرين لما واحد بشتري بتلاقي الكل + +250 +00:18:59,530 --> 00:19:03,830 +اللي بشتري معاه هذا بيسموه سياسة القطيع اه سياسة + +251 +00:19:03,830 --> 00:19:08,470 +القطيع فهي هذا مقال حلو كتير فبروحاش ممكن ناخده + +252 +00:19:08,470 --> 00:19:11,750 +okay بنعمل عليه clickأو تكتبيه على هيك على دفتر و + +253 +00:19:11,750 --> 00:19:14,290 +.. شوفوا احنا من مقال واحد هنكتب ال assignment + +254 +00:19:14,290 --> 00:19:18,710 +سبعنا كله مقالة واحدة بس وهي هتساعدنا ان نجيب كل + +255 +00:19:18,710 --> 00:19:24,190 +المقالات المرتبطة فيهايعني لو وجدنا مثلا واحد بروح + +256 +00:19:24,190 --> 00:19:27,890 +ناخد هيك نطلع كمان هو barbari's etal prospect + +257 +00:19:27,890 --> 00:19:32,970 +theory and asset price هذا is important a model of + +258 +00:19:32,970 --> 00:19:36,430 +the investment sentiment investment sentiment يعني + +259 +00:19:36,430 --> 00:19:40,150 +معناها ال investor behavior هذا is important فممكن + +260 +00:19:40,150 --> 00:19:44,870 +نحطه هاي صار عندى three articles تلات مقالاتبتبقى + +261 +00:19:44,870 --> 00:19:49,170 +لنا كمان ندور قبل أن .. على الأقل هنجدلنا تلت أربع + +262 +00:19:49,170 --> 00:19:54,010 +مقالات تمام؟ مثلا هاي the value of information + +263 +00:19:54,010 --> 00:19:57,510 +when preferences are dynamics inconsistent فكده + +264 +00:19:57,510 --> 00:19:59,870 +لما حكينا أنه احنا ال behavioral finance تعتمد على + +265 +00:19:59,870 --> 00:20:04,010 +ال public information فهي هاي مقال بحكي عن ال + +266 +00:20:04,010 --> 00:20:11,770 +information و هكذاطبعا فهذا مقال .. مقال واحد بس + +267 +00:20:11,770 --> 00:20:15,250 +حكينا في ال .. او تلت اربع مقالات طلعناهم بس من + +268 +00:20:15,250 --> 00:20:18,130 +مقال واحد من behavioral finance هاي مثلا market + +269 +00:20:18,130 --> 00:20:20,490 +efficiency فاكرين لما احنا حكينا market efficiency + +270 +00:20:20,490 --> 00:20:25,530 +هذا اهم شوفوا فاهمة لما .. فا .. يجين فاهمة هذا + +271 +00:20:25,530 --> 00:20:28,730 +اهم واحد كتب بال .. بال behavioral finance يعني + +272 +00:20:28,730 --> 00:20:31,370 +هاي market efficiency فاكرين لما احنا تناقض market + +273 +00:20:31,370 --> 00:20:33,770 +efficiency و ال long term returns و ال behavioral + +274 +00:20:33,770 --> 00:20:39,330 +finance هذا this isD'accord هذا الأساس أي واحد لما + +275 +00:20:39,330 --> 00:20:43,190 +أنا بقى أصلح ال assignments سبعكم إذا ما لاجيتش + +276 +00:20:43,190 --> 00:20:48,470 +أجين و فامة .. أجين فامة بقول إنه مش .. مش كتير ال + +277 +00:20:48,470 --> 00:20:53,250 +.. ال assignments تمام؟ مش .. مش كتير ال + +278 +00:20:53,250 --> 00:20:57,730 +assignments ففي key .. key article .. key people + +279 +00:20:57,730 --> 00:21:03,860 +لازم نعرفهم لما إحنا نحكي في أي موضوعأه بأي موضوع + +280 +00:21:03,860 --> 00:21:07,920 +يعني مثلا أنتوا بتحكوا عن الإسلام مثلا حكينا كتير + +281 +00:21:07,920 --> 00:21:10,180 +و هذا و ماذاكرناش الرسول صلى الله عليه وسلم + +282 +00:21:10,180 --> 00:21:13,800 +مابنفع؟ و إيش الفادة يعني أنتوا بتحكوا عن الإسلام + +283 +00:21:13,800 --> 00:21:19,400 +و المظبوط ولا لأ؟ أو حكينا مثلا أهمية الصيام ولا + +284 +00:21:19,400 --> 00:21:22,980 +جيبنا آية كريمة ولا جيبنا قرآن كريم ولا جيبنا حديث + +285 +00:21:22,980 --> 00:21:27,940 +ولا جيبنا أي شيء ف .. فاحنا بنيجي في المقالات + +286 +00:21:27,940 --> 00:21:32,470 +العلميةلما نيجي نحكي عن ال behavioral finance مثلا + +287 +00:21:32,470 --> 00:21:39,410 +أهم ناس اللي هو أوجينه فامع فامع فامع أهم واحد كتب + +288 +00:21:39,410 --> 00:21:45,030 +بال behavioral finance فبدنا احنا لازم نعرف ال key + +289 +00:21:45,030 --> 00:21:45,410 +people + +290 +00:21:48,640 --> 00:21:52,880 +من هم الأشخاص الرئيسيين طبعا كيف ممكن احنا نعرف ال + +291 +00:21:52,880 --> 00:21:57,040 +key people هذول هاي سهلة جدا يعني لو احنا أخدنا + +292 +00:21:57,040 --> 00:22:04,140 +المقال سبع FAMA market + +293 +00:22:04,140 --> 00:22:12,360 +efficiency + +294 +00:22:12,360 --> 00:22:17,470 +فهو اهم واحد بيحكي عن ما هو market efficiencyحكينا + +295 +00:22:17,470 --> 00:22:21,710 +أولا science direct سجلته شغل تاني أنه احنا ممكن + +296 +00:22:21,710 --> 00:22:24,630 +نعتمد عليها ال google schooler ال google ايش + +297 +00:22:24,630 --> 00:22:28,470 +schooler مش ال google العادي لأن ال google + +298 +00:22:28,470 --> 00:22:31,530 +schooler هو بس بحط المقالات العلمية محطش الربش + +299 +00:22:31,530 --> 00:22:38,190 +okay طبعا + +300 +00:22:38,190 --> 00:22:42,090 +كيف احنا بنسأل ال google scholar تروحوا scholar ا + +301 +00:22:42,090 --> 00:22:47,830 +وتحطوا scholar هيك و تروحوا googleوهنا وصلنا ل + +302 +00:22:47,830 --> 00:22:57,850 +جوجل مثلا بدنا موضوع بال behavioral finance ايوة + +303 +00:22:57,850 --> 00:23:01,810 +اتطلعوني بالله انا كيف .. كيف بد اعرف انا ان هذا + +304 +00:23:01,810 --> 00:23:08,130 +مقال مهم ولا مش مهم؟ مين بعرف؟ اول واحد كيف .. كيف + +305 +00:23:08,130 --> 00:23:10,830 +باعرف؟ مش شرط تكون اول واحد okay صح كرامك اول واحد + +306 +00:23:10,830 --> 00:23:15,870 +بس في شغل اهم من اول واحديعني انا مثلا اخدت فاكرين + +307 +00:23:15,870 --> 00:23:19,930 +احنا اخدنا في ال .. اختارنا مقال من ال science + +308 +00:23:19,930 --> 00:23:25,460 +direct طلعنا عليهمو اخترنا اربع خمس مقالات بس بدي + +309 +00:23:25,460 --> 00:23:28,820 +انا اعرف مين اهم واحد فيهم بروح على google scholar + +310 +00:23:28,820 --> 00:23:33,500 +google scholar بساعدني كتير عشان اعرف مين المهم و + +311 +00:23:33,500 --> 00:23:37,080 +ممكن ال science direct كمان بيساعدني اتطلعوا في ال + +312 +00:23:37,080 --> 00:23:39,140 +science direct اتطلعوا على ال science direct + +313 +00:23:39,140 --> 00:23:45,840 +انتبهوا هنا ايش مكتوب هنا cited by 827 عملوا cite + +314 +00:23:45,840 --> 00:23:50,180 +127 127 okay ايش يعني cite يعني أكم واحد معتمد على + +315 +00:23:50,180 --> 00:23:54,870 +هذه الورقةماخد عليها 127 طب لو جينا لغير واحد + +316 +00:23:54,870 --> 00:24:00,110 +تسعين مش كتير طب ما 127 هذا أكتر واحد هذا اتناش مش + +317 +00:24:00,110 --> 00:24:04,850 +كتير هذا سبعة مش كتير اتناش اذا لحالنا هنعرف أن + +318 +00:24:04,850 --> 00:24:10,530 +أهم واحد هو هذا أكتر اعتماد أكتر اعتماد و + +319 +00:24:10,530 --> 00:24:15,270 +الأربعمية وين عندك أربعمية ها؟ وين؟800 ما حنا + +320 +00:24:15,270 --> 00:24:20,130 +حكينا فيه okay أخدناها على .. أخدناها على ال .. + +321 +00:24:20,130 --> 00:24:23,910 +على google scholar scholar هنا و أكم واحد عمله + +322 +00:24:23,910 --> 00:24:28,130 +citation 3448 + +323 +00:24:28,130 --> 00:24:35,350 +يعني 3448 مقالة علمية اعتمدت على هذا المقالة و + +324 +00:24:35,350 --> 00:24:39,870 +حضرتنا احنا بدناش يعني ناخد منه حضرتنا يعني احنا + +325 +00:24:39,870 --> 00:24:44,220 +في ال assignment سبقناالأول نقطة اللى حكينا فيها + +326 +00:24:44,220 --> 00:24:46,980 +ال coherence التانى النقطة اللى بنحكي فيها ال + +327 +00:24:46,980 --> 00:24:49,240 +reference تبعتنا مين هي ال reference not any + +328 +00:24:49,240 --> 00:24:54,640 +reference و بتشوف شباب و بنات حاطين لش اسمه ال + +329 +00:24:54,640 --> 00:24:59,380 +link I don't need to see the link ال link مابديش + +330 +00:24:59,380 --> 00:25:05,920 +اشوف وجه ال link نهائي بدي اشوف لو كتاب اكتبين او + +331 +00:25:05,920 --> 00:25:09,160 +مقالة مقالتين بيكون بكفيني انا مالزمنيش اكتر من + +332 +00:25:09,160 --> 00:25:14,940 +هيك تمام؟طيب الو احنا أخدنا ال behavioral finance + +333 +00:25:14,940 --> 00:25:19,820 +هذا ال article + +334 +00:25:19,820 --> 00:25:23,680 +هاي + +335 +00:25:23,680 --> 00:25:31,680 +direct و ننزله عندنا و ننزله PDF و نقرأه هذا اللي + +336 +00:25:31,680 --> 00:25:36,440 +احنا ممكن نشترل عليه طب كيف احنا نعمل ال + +337 +00:25:36,440 --> 00:25:41,550 +reference؟ال reference كيف نعمله أنا جهزتلكم مقالة + +338 +00:25:41,550 --> 00:25:44,710 +علمية عاملة references في many styles to do + +339 +00:25:44,710 --> 00:25:49,510 +references كتير styles بتعمل references ال + +340 +00:25:49,510 --> 00:25:55,690 +references إذا كان في داخل المقال بختلف عن ما هو + +341 +00:25:55,690 --> 00:26:02,810 +في ال references فلو احنا طلعنا هنا على المقالة + +342 +00:26:02,810 --> 00:26:06,450 +هذه المكتوبة هتشوفوا + +343 +00:26:11,200 --> 00:26:13,860 +لو شوفنا ال document map ضروري ان تكون عندكوا + +344 +00:26:13,860 --> 00:26:17,020 +document map زى هذه انا هورجيكوا كيف ممكن نعملها + +345 +00:26:17,020 --> 00:26:21,540 +شايفين ال document map على الشمال okay هذه يعني + +346 +00:26:21,540 --> 00:26:25,200 +انا سهل جدا اروح access اروح اى موضوع فنروح على ال + +347 +00:26:25,200 --> 00:26:28,160 +references اذا موجودة عندنا هى ال references ال + +348 +00:26:28,160 --> 00:26:31,500 +references هى هذه موجودة في نهاية ال .. في نهاية + +349 +00:26:31,500 --> 00:26:38,180 +ال article هى مثلا اسم العابدي واحد اسمه عابدي و + +350 +00:26:38,180 --> 00:26:44,110 +hitch طبعا هذا style Harvardيعني بنكتب الاسم ال + +351 +00:26:44,110 --> 00:26:50,570 +family بعدين الحرف الأول من اسمه ممكن طبعا فى ناس + +352 +00:26:50,570 --> 00:26:55,070 +بكتبوا الاسم كامل أنا ماعنديش مشكلة بعدين زى ما + +353 +00:26:55,070 --> 00:27:02,650 +تشايفين السنة بعدين بنكتب اسم المقالة كاملة بعدين + +354 +00:27:02,650 --> 00:27:07,470 +من المكان النشر تبعها تمام؟ من وين ممكن نحصل + +355 +00:27:07,470 --> 00:27:13,010 +عليها؟ هى كمان واحد bandsاسم المقال الجورنال + +356 +00:27:13,010 --> 00:27:18,530 +انتشرت فيها ال issue و ال edition و ال pages تلاتة + +357 +00:27:18,530 --> 00:27:23,850 +لتمنتاش يعني هذه من تلاتة لتمنتاش صفحة تمام فهذا + +358 +00:27:23,850 --> 00:27:29,250 +بيساعدكم هذا إذا كان في نهاية ال reference لو إحنا + +359 +00:27:29,250 --> 00:27:33,470 +بدنا نعرف كيف نعمل reference في في المحتوى نفسه + +360 +00:27:33,470 --> 00:27:40,130 +تطلعوا يعني أنا بدأ أكبرلكم الخط شوية أساس تشوفوا + +361 +00:27:42,340 --> 00:27:47,800 +control شوفوا الخطك بده كبر شوية بيكبر اه okay سهل + +362 +00:27:47,800 --> 00:27:55,700 +الشوفوا Banz مثلا شايفين Banz Banz 1981 has done + +363 +00:27:55,700 --> 00:27:59,980 +research in this field his study يعني دراسته حكت + +364 +00:27:59,980 --> 00:28:04,520 +واحد تانين تلاتة اربعة خمسة طب بنشوف غير Banz طب + +365 +00:28:04,520 --> 00:28:08,840 +اذا كان اكتر من واحد نشوف كيف اكتر من واحد هنجد + +366 +00:28:08,840 --> 00:28:14,650 +اكتر من واحدطبعا إذا كنا بنحكي في بداية الجملة أو + +367 +00:28:14,650 --> 00:28:17,890 +في وسط الجملة لو إحنا بنعمل reference بداية الجملة + +368 +00:28:17,890 --> 00:28:22,990 +أو وسط الجملة بنقول مثلا افلان فلاني حكى behavior + +369 +00:28:22,990 --> 00:28:24,710 +of finance هي هي هي هي هي هي هي هي هي هي هي هي هي + +370 +00:28:24,710 --> 00:28:24,750 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +371 +00:28:24,750 --> 00:28:24,750 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +372 +00:28:24,750 --> 00:28:26,250 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +373 +00:28:26,250 --> 00:28:26,250 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +374 +00:28:26,250 --> 00:28:28,970 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +375 +00:28:28,970 --> 00:28:32,390 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +376 +00:28:32,390 --> 00:28:32,390 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +377 +00:28:32,390 --> 00:28:32,450 +هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي هي + +378 +00:28:32,450 --> 00:28:36,490 +هي هي هي هي هي هي هي + +379 +00:28:36,490 --> 00:28:43,430 +هي هي هيفاصلة ألف وتسعمية وتسعين و بتسكر هذا إذا + +380 +00:28:43,430 --> 00:28:46,730 +كانت في نهاية الجملة حكينا كلامه و بعدين هذا + +381 +00:28:46,730 --> 00:28:49,810 +الكلام لمين الحكاه؟ bands ممكن انا في عندى + +382 +00:28:49,810 --> 00:28:52,670 +تاريختين انا اعمل reference ل bands اقول bands + +383 +00:28:52,670 --> 00:28:56,950 +nineteen ninety says blah blah blah او اكتب شو + +384 +00:28:56,950 --> 00:29:00,090 +حكاه و بعدين تحت اللي هو اكتب ال .. اللي هو bands + +385 +00:29:00,090 --> 00:29:07,520 +اللي حكى الكلاملأ هذا في styles بختلف بس احنا ال + +386 +00:29:07,520 --> 00:29:13,480 +styles اللي نحكي ال high quality style okay بعتمد + +387 +00:29:13,480 --> 00:29:17,080 +الطريقة اللي انا بحكي فيها طبعا يعني هنا مثلا + +388 +00:29:17,080 --> 00:29:20,620 +bands بتدهد في نهاية الجملة و طبعا بدوا يكونوا ان + +389 +00:29:20,620 --> 00:29:25,800 +انتوا تكونوا عندكم اللغة اللي تستاعدكم مثلا انا + +390 +00:29:25,800 --> 00:29:34,370 +حكيت bands 1990 claimsthat blah blah blah طب راح + +391 +00:29:34,370 --> 00:29:39,790 +واحد تاني غير bands مثلا فاما فاما طبعا نقطة و إذا + +392 +00:29:39,790 --> 00:29:48,870 +كانت نفس الحكي فنروح نكمل فاما 1996 for instance + +393 +00:29:48,870 --> 00:29:54,510 +argues فشوفوا أنا استخدمت claim و استخدمت argues + +394 +00:29:54,510 --> 00:29:59,410 +فمش حلو كتير أستخدم claims claims claimsأنا استخدم + +395 +00:29:59,410 --> 00:30:05,390 +نفس المصطلحات يعني بالعربي مثلا فاما بيقول .. يقول + +396 +00:30:05,390 --> 00:30:12,430 +أن ال behavioral finance كذا كذا كذا فاما يعرف .. + +397 +00:30:12,430 --> 00:30:16,290 +شوفوا استخدمنا كلمة أخرى بحيث أنه يصير في عندكم + +398 +00:30:16,290 --> 00:30:20,690 +يعني you are digesting the language أنه احنا عملنا + +399 +00:30:20,690 --> 00:30:24,160 +digesting لإن احنا بتشربين اللغة مظبوطمش just لو + +400 +00:30:24,160 --> 00:30:28,880 +احنا repeat the same things هذا اذا كان واحد اللي + +401 +00:30:28,880 --> 00:30:34,060 +كاتب ال .. اذا كان اكتر من واحد هندور على اكتر من + +402 +00:30:34,060 --> 00:30:39,660 +واحد كاتبيه مثلا ال .. شوفوا هاي مثلا Foster and + +403 +00:30:39,660 --> 00:30:44,560 +Stein طلعوا كيف Foster and Stein كيف .. كيف + +404 +00:30:44,560 --> 00:30:52,160 +معقولها referencesهي شايفين؟ Foster and Stein 2003 + +405 +00:30:52,160 --> 00:30:55,640 +studied the incremental added value of the meaning + +406 +00:30:55,640 --> 00:31:00,480 +-reverting trading strategies okay they هه طبعا + +407 +00:31:00,480 --> 00:31:03,440 +مين they؟ ترجع لمين they؟ بالظبط مش أعيدهم كمرة + +408 +00:31:03,440 --> 00:31:10,620 +they ها Foster and كذا okay فهذا ايش ال .. how to + +409 +00:31:10,620 --> 00:31:14,820 +do the references بتلاحظوا لو احنا اجينا لكل .. + +410 +00:31:15,600 --> 00:31:19,440 +paragraph من هدول ال paragraph اللي نجد انه ال + +411 +00:31:19,440 --> 00:31:24,220 +references خوية كتير اذا كان تبقى اذا كان عندنا + +412 +00:31:24,220 --> 00:31:28,440 +two articles اتنين two writers طب لو كانوا تلاتة + +413 +00:31:28,440 --> 00:31:34,900 +او اكتر مين بيعرف كيف نعمل لهم نجيبلكم يلا مين + +414 +00:31:34,900 --> 00:31:44,640 +others طب بالانجليزي ايش نحكي اه طلعاتطلعوا اذا + +415 +00:31:44,640 --> 00:31:48,780 +كان اكتر من واحد اذا + +416 +00:31:48,780 --> 00:31:54,840 +كان اكتر من واحد بنحكي ايش اتشاو ايتال ايتال معناه + +417 +00:31:54,840 --> 00:32:02,400 +واخرون ايتال ايتال ايتال ايتال لحظهان شوه ايتال + +418 +00:32:02,400 --> 00:32:04,360 +نقطة الفين واربع + +419 +00:32:07,610 --> 00:32:10,670 +شفتوا كيف؟ يعني انا أورجلتكم لو كان reference + +420 +00:32:10,670 --> 00:32:14,310 +لواحد لو كان reference لاتنين لو كان reference + +421 +00:32:14,310 --> 00:32:20,550 +لتلاتة okay فإذا كان واحد is fine two are fine but + +422 +00:32:20,550 --> 00:32:25,310 +three more than three so you have to include اتقال + +423 +00:32:25,310 --> 00:32:31,330 +زي ما هي اتقال لكن بال reference تبعنا بال + +424 +00:32:31,330 --> 00:32:35,470 +reference تبعنا كلهم لانحطهم يعني لو احنا جيبنا + +425 +00:32:35,470 --> 00:32:42,240 +تشوةنشوف اتشاوة هذا الرجال لو روحنا دورنا عليه بال + +426 +00:32:42,240 --> 00:32:47,860 +reference هروحنا على ال reference و نعرف اتشاوة CH + +427 +00:32:47,860 --> 00:32:52,060 +هاي + +428 +00:32:52,060 --> 00:33:02,320 +اتشاوة شوفت اتشاوة؟ كيف نعمله reference اتشاوة + +429 +00:33:02,320 --> 00:33:04,880 +اتشاوة + +430 +00:33:08,230 --> 00:33:14,080 +هو الاسم طبعا هذا اسمه مختصر اسم النام سابقههذا + +431 +00:33:14,080 --> 00:33:16,820 +بيكون ال family name هذا بيكون ال .. ال fast name + +432 +00:33:16,820 --> 00:33:24,400 +تبعه و هذا K و W و .. و رمزها Maui و K طبعا هدول + +433 +00:33:24,400 --> 00:33:27,900 +مبينين يا Japanese يا Chinese يا اما يابانيين يا + +434 +00:33:27,900 --> 00:33:32,380 +.. هنعرف من وين profiteering trading mechanisms و + +435 +00:33:32,380 --> 00:33:38,680 +ال .. okay trading strategies طبعا فهذا ايش اتشوى + +436 +00:33:43,750 --> 00:33:47,930 +إذا عرفنا لو كان واحد لو كان اتنين لو كان تلاتة + +437 +00:33:47,930 --> 00:33:50,430 +فاهمنا إذا هي النقطة التانية حكينا على ال + +438 +00:33:50,430 --> 00:33:55,790 +coherence و حكينا على ال references طبعا إذا بشوف + +439 +00:33:55,790 --> 00:33:59,730 +أنا references مش كتير you are not follow this + +440 +00:33:59,730 --> 00:34:04,750 +style مع الكلام it may influence on your mark ممكن + +441 +00:34:04,750 --> 00:34:13,130 +تأثر على الدرجة تبعتكمطبعا؟ so be careful in .. in + +442 +00:34:13,130 --> 00:34:23,210 +doing this طيب من وين؟ من وين ممكن تجيب المجلة؟ + +443 +00:34:23,210 --> 00:34:25,370 +إذا أخدتيه واش من هنا، من وين ممكن تجيبيه؟ من + +444 +00:34:25,370 --> 00:34:28,150 +المكتب، مش ممكن .. مش إنت عارف أنا أخده من المكتب؟ + +445 +00:34:28,150 --> 00:34:36,610 +ممكن، و الله هيبقون نور على نور بقى .. إيه؟والله + +446 +00:34:36,610 --> 00:34:45,130 +أنا خبرتي بتقول انه يعني .. يعني مثلا واحد عنده + +447 +00:34:45,130 --> 00:34:50,450 +مية دولم أرض بده يزرعهم تمام؟ + +448 +00:34:50,450 --> 00:34:55,730 +أمامه خيارين يجيب هال بالدوزر هذا و بثواني يعمل + +449 +00:34:55,730 --> 00:34:59,410 +هالمية دولم أو بدقائق أو يروح يمسك الفاسق و يبدأ + +450 +00:34:59,410 --> 00:35:03,750 +يشتغل فيهم واحد واحد فال .. ال .. المكتب أصلا ما + +451 +00:35:03,750 --> 00:35:08,010 +هي موجودة هناالمكتبة كلها و خاصة إذا الجامعة + +452 +00:35:08,010 --> 00:35:10,690 +الاسلامية في إلها access يلاحظوا هان لما احنا + +453 +00:35:10,690 --> 00:35:13,030 +روحنا على google scholar أو على ال science direct + +454 +00:35:13,030 --> 00:35:17,650 +نتبهوا في ملاحظة مهمة لازم تتبهوا إلها اطلعوا ع + +455 +00:35:17,650 --> 00:35:21,530 +أيديكوا اليمين مكتوب ع أيديكوا اليمين brought to + +456 +00:35:21,530 --> 00:35:24,630 +you Islamic university of Gaza الجامعة الاسلامية + +457 +00:35:24,630 --> 00:35:28,310 +مش تركة في هذا ال .. في هذا ال science direct + +458 +00:35:28,310 --> 00:35:32,210 +فمعناة كلها ممكن تروح على المكتبة ماتجدوش المقالة + +459 +00:35:32,210 --> 00:35:40,520 +بس تجدوها موجودة هنافهمتي كيف؟ عادي فانتبهوا + +460 +00:35:40,520 --> 00:35:45,340 +للكلام اللي ممكن تروح على المكتب لكن مش كل إشي + +461 +00:35:45,340 --> 00:35:51,660 +موجود طبعا و خاصة اليوم بالثورة التكنولوجية يعني + +462 +00:35:51,660 --> 00:36:00,780 +يعني أنا مثلا بآخر ست سنوات بالمجال الأكاديمي تبعي + +463 +00:36:00,780 --> 00:36:04,940 +أو بالمجال ال researchصحيح كنا نجلس في المكتبة لكن + +464 +00:36:04,940 --> 00:36:09,360 +ما نستخدمش ال .. ال .. ال hard copy ما نستخدمش ال + +465 +00:36:09,360 --> 00:36:12,540 +hard copy نستخدم soft copy يعني احنا نعمل access + +466 +00:36:12,540 --> 00:36:16,700 +من المكتبة لأنه في جو مريح و في هدوء و في كذا و + +467 +00:36:16,700 --> 00:36:19,080 +اذا عجبنا ال article نعمله printing out في المكتبة + +468 +00:36:19,080 --> 00:36:22,100 +و نقرأه في المكتبة هالمكتبة وجدت عشان احنا نعمل + +469 +00:36:22,100 --> 00:36:25,740 +focus و في بعض ال facilities ما بنستخدمهاش الا + +470 +00:36:25,740 --> 00:36:30,910 +داخل المكتبةو خاصة بعض ال database لو احنا طلعنا + +471 +00:36:30,910 --> 00:36:33,030 +برا المكتب مش هتكون احنا مسموح إلنا خاصة + +472 +00:36:33,030 --> 00:36:36,730 +electronic database خدمات إلكترونية مش هنقدر + +473 +00:36:36,730 --> 00:36:39,970 +نعملها access خارج المكتب بتكون داخل المكتب okay + +474 +00:36:39,970 --> 00:36:49,330 +طيب إذا حكينا عن ال structure of writing استخدموا + +475 +00:36:49,330 --> 00:36:53,070 +كمان ممكن تستخدم footnotesيعني حكينا عن ال + +476 +00:36:53,070 --> 00:36:56,050 +coherence حكينا عن ال references نحكي عن ال + +477 +00:36:56,050 --> 00:36:59,990 +footnotes ايش يعني ال footnotes انا امبارح اجاني + +478 +00:36:59,990 --> 00:37:06,070 +شاب و جاب لي المقال سبعه ال assignments فإيش مكتوب + +479 +00:37:06,070 --> 00:37:14,130 +في ال assignments مكتوب بلا بلا بلا I O U أو خلينا + +480 +00:37:14,130 --> 00:37:16,250 +نحكي أنه مثلا on R + +481 +00:37:23,100 --> 00:37:27,420 +OE مثلا return on equity في طبعا احنا عندنا + +482 +00:37:27,420 --> 00:37:30,400 +طريقتين ممكن نتعامل مع ال .. مع ال abbreviations + +483 +00:37:30,400 --> 00:37:34,360 +هذه الطريقة الأولى أول مرة بتكتب ال return on + +484 +00:37:34,360 --> 00:37:40,820 +equity أول مرة تكتب return on equity okay return + +485 +00:37:40,820 --> 00:37:46,220 +on equity خلاص بعد هيك بتصير تحط ROE هل الشاب لأ + +486 +00:37:46,220 --> 00:37:49,020 +عمل هيك ولا ايش؟ خلاص حاطط هيك فانا بسأله ايش هذا + +487 +00:37:49,020 --> 00:37:52,580 +بقول مابعرفشطب .. طب what it means بابا؟ أنا + +488 +00:37:52,580 --> 00:37:56,240 +ماعرفش، don't tell me I don't know because it is + +489 +00:37:56,240 --> 00:38:00,860 +your responsibility in every word that you write، + +490 +00:38:00,860 --> 00:38:03,700 +مسئوليتها في كل كلمة أنت كاتبها otherwise somebody + +491 +00:38:03,700 --> 00:38:07,780 +else do the assignment الحل الآخر أنه ناس تانين + +492 +00:38:07,780 --> 00:38:10,560 +عملولك ال assignment، so I intentionally ask him, + +493 +00:38:10,640 --> 00:38:12,640 +he said I don't know, I said okay take your + +494 +00:38:12,640 --> 00:38:14,960 +assignment and when you know deliver your + +495 +00:38:14,960 --> 00:38:19,360 +assignmentخد الأصانع تبعتك و كل ما تعرف ابتجيني + +496 +00:38:19,360 --> 00:38:29,160 +فإيش الشاب عامل IOU هتطها طب okay what it means he + +497 +00:38:29,160 --> 00:38:35,460 +keep silence ف either to for instance investments, + +498 +00:38:36,140 --> 00:38:41,120 +utility, opportunity and utilities for instance + +499 +00:38:41,120 --> 00:38:43,950 +this is the abbreviationsyou either put it like + +500 +00:38:43,950 --> 00:38:48,730 +this or do like footnotes use the footnotes ايش ال + +501 +00:38:48,730 --> 00:38:53,270 +footnotes ال footnotes اللي احنا التعريفة هذه + +502 +00:38:53,270 --> 00:39:00,950 +نحطها في الهامش تحت هنورجيكوا إياها لو + +503 +00:39:00,950 --> 00:39:09,830 +شوفنا احنا هاي ال assignments okay + +504 +00:39:09,830 --> 00:39:11,350 +اتطلعوا على ال assignments هان + +505 +00:39:14,770 --> 00:39:21,210 +هنجد في somewhere انه الراجل مستخدم footnotes + +506 +00:39:21,210 --> 00:39:26,650 +طلعوا + +507 +00:39:26,650 --> 00:39:33,890 +هان شايفين طبعا هو معرف sigma شوفوا هان رقم اللي + +508 +00:39:33,890 --> 00:39:38,290 +هي رقم أربعة شايفينها هان الصغيرة شايفينهاSigma + +509 +00:39:38,290 --> 00:39:42,770 +يعني واحدة من هالبنات و لا من هالولاد راح كاتبلي + +510 +00:39:42,770 --> 00:39:48,050 +we can measure the financial risk by using sigma + +511 +00:39:48,050 --> 00:39:53,810 +it was fine do you know what it means sigma I + +512 +00:39:53,810 --> 00:39:57,550 +don't know so if you don't know please don't write + +513 +00:39:57,550 --> 00:40:04,460 +it unless you understand itتكتبليش أي إشي مش فاهمه + +514 +00:40:04,460 --> 00:40:08,420 +يعني انا في one of the prestigious students واحد + +515 +00:40:08,420 --> 00:40:10,240 +من ال prestigious students you know what it means + +516 +00:40:10,240 --> 00:40:13,620 +prestigious students واحد منه و كان الطالب طبعا + +517 +00:40:13,620 --> 00:40:19,380 +كاتب شغلة فانا قلتلها don't show me your stupidity + +518 +00:40:19,380 --> 00:40:23,160 +ماتورجليش قداش انت غبي why؟ + +519 +00:40:24,730 --> 00:40:28,690 +هي كاتبة شغلة I know she doesn't understand what + +520 +00:40:28,690 --> 00:40:32,230 +it means حاولي just write things that you + +521 +00:40:32,230 --> 00:40:35,890 +understand + +522 +00:40:35,890 --> 00:40:39,210 +أكتفوا الشغلة بس اللي بتفهموها الشغلة اللي ما + +523 +00:40:39,210 --> 00:40:43,170 +تفهموهاش و ما تورجونيهش يداش هذا الأستاذ تبعي مرة + +524 +00:40:43,170 --> 00:40:47,470 +كتبت شغلة أنا فاهمها في راسي كنت أو حتى يمكن + +525 +00:40:47,470 --> 00:40:50,770 +ماكنتش فاهمها لو بقولي well I will advise you one + +526 +00:40:50,770 --> 00:40:55,860 +thingshow me how you are smart don't show me how + +527 +00:40:55,860 --> 00:41:00,820 +you are stupid اه وارجيني كده انت شاطر ماتورجينيش + +528 +00:41:00,820 --> 00:41:05,040 +كده انت غبي طبعا كيف اكتشف شغلانه اعمل شغل انا + +529 +00:41:05,040 --> 00:41:10,020 +مااخدها من واحد وانا مش عارفها انا يعني just + +530 +00:41:10,020 --> 00:41:13,700 +stuffing يعني انا بحكي about myself انا بحكي على + +531 +00:41:13,700 --> 00:41:20,160 +نفسيSo try to avoid في طبعا كل إنسان احنا ما احنا + +532 +00:41:20,160 --> 00:41:25,180 +وصلنا من درجة العلم انه نحكي درجة الكمال لأ كل + +533 +00:41:25,180 --> 00:41:30,980 +إنسان في عنده أشياء لا يعرف فيها الشغيات اللي انت + +534 +00:41:30,980 --> 00:41:36,090 +ما بتعرف فيها ما تكتبهاunless ان انت you recession + +535 +00:41:36,090 --> 00:41:39,670 +it, understand it and then put it in your .. لإن + +536 +00:41:39,670 --> 00:41:42,670 +واحد راح انت نشرت المقال و واحد سألك اتصل فيك + +537 +00:41:42,670 --> 00:41:45,750 +تليفون جالك طب okay انت عامل الشغل هذي و أنا مش + +538 +00:41:45,750 --> 00:41:54,170 +فاهمها ممكن تفهمليها؟ اش بيصير؟ تمام؟ + +539 +00:41:55,830 --> 00:42:01,090 +مرة أنا كتبت على موضوع .. موضوع بال .. بال .. بشغل + +540 +00:42:01,090 --> 00:42:06,090 +اسمه ال .. بال finance فواحد في جامعة university + +541 +00:42:06,090 --> 00:42:13,510 +of .. نسيت الجامعة في Warwick فبتستر أفنانه أخد ال + +542 +00:42:13,510 --> 00:42:16,450 +email تبعيه و هذا و بعت ال email قال can I call + +543 +00:42:16,450 --> 00:42:19,480 +you okayو اتصل فيه تليفون و قال لي انا في ال + +544 +00:42:19,480 --> 00:42:24,180 +equation هادى بال leads and lags انا يعني حاولت + +545 +00:42:24,180 --> 00:42:26,940 +اطبقها بالستاتة و مش واضحة عندي ممكن يعني تساعدني + +546 +00:42:26,940 --> 00:42:31,160 +اشتري free time و كذا فتصوروا ان انا حاطط شغلة مش + +547 +00:42:31,160 --> 00:42:38,480 +عارف كيف معمولة بصيب بمشكلة ولا لأ؟ okay so try to + +548 +00:42:38,480 --> 00:42:40,980 +.. any things include in your assignment to + +549 +00:42:40,980 --> 00:42:43,740 +understand it you don't need to read things that + +550 +00:42:43,740 --> 00:42:47,680 +you don't understandتمام؟ فشوفنا ال footnotes اللى + +551 +00:42:47,680 --> 00:42:52,440 +هو عندنا ال sigma اللى انكتبت ال sigma وعرفناها ال + +552 +00:42:52,440 --> 00:42:58,940 +sigma اللى هى .. خلّيني أحكي control F بدنا sigma + +553 +00:42:58,940 --> 00:43:03,020 +شوفوا + +554 +00:43:03,020 --> 00:43:09,780 +هى sigma شايفينها sigma هن؟مكتوب and these extreme + +555 +00:43:09,780 --> 00:43:13,180 +values are not confined three sigmas طب احنا + +556 +00:43:13,180 --> 00:43:18,650 +حكيتها three sigmas شو هم ال three sigmas هدول؟we + +557 +00:43:18,650 --> 00:43:22,270 +don't know يعني even me I don't know so explain + +558 +00:43:22,270 --> 00:43:26,550 +this فبنحط في الفوتناو ستهت okay sigma is a + +559 +00:43:26,550 --> 00:43:30,050 +standard deviation about ninety nine point seven + +560 +00:43:30,050 --> 00:43:34,190 +percent of a normal distribution m zero one is + +561 +00:43:34,190 --> 00:43:39,270 +confined to three sigmas خلاص وضحكت عرفت what it + +562 +00:43:39,270 --> 00:43:45,710 +means sigma الطريقة التانية ان احنا بتعملي sigma + +563 +00:43:45,710 --> 00:43:51,620 +طريقة ثانية sigmaو بتعمل between quotation و + +564 +00:43:51,620 --> 00:43:57,780 +بتروحي بتحطيها بانجوسان that's it ممكن نحط ال + +565 +00:43:57,780 --> 00:44:07,220 +abbreviations + +566 +00:44:07,220 --> 00:44:11,700 +و نحط ال sigma هذه كلها فهمش الحال طب إذا في كان + +567 +00:44:11,700 --> 00:44:14,660 +أكتر من تعريف ل sigma ممكن نحط sigma و نقول other + +568 +00:44:14,660 --> 00:44:19,750 +people explain sigma like thisOkay فانتبهنا لل + +569 +00:44:19,750 --> 00:44:23,390 +footnotes how you can use the footnotes يعني بيكون + +570 +00:44:23,390 --> 00:44:31,330 +بيكون مرات strange concept strange concept مصطلحات + +571 +00:44:31,330 --> 00:44:39,070 +غريبة و خاصة ممكن مصطلحات لاتينية okay يعني مثلا + +572 +00:44:39,070 --> 00:44:42,210 +لما نحكي عن random walk okay random walk what it + +573 +00:44:42,210 --> 00:44:45,810 +means فلازم يكون عندنا وضوح فيها طيب + +574 +00:44:49,600 --> 00:44:54,700 +فالأول صفحة عندنا بنات هي أول صفحة أنا بدأ أكتب ال + +575 +00:44:54,700 --> 00:44:59,280 +assignment تبعي ال assignment تبعي أول صفحة بتكتب + +576 +00:44:59,280 --> 00:45:02,480 +فيها التفاصيل تبعتكم زي ما هي موجودة هنا تلعبوا + +577 +00:45:02,480 --> 00:45:10,320 +التفاصيل خليكي أحسن التفاصيل + +578 +00:45:10,320 --> 00:45:15,660 +اسم السؤال اللي انتوا هتتعاملوا عليه تمام واسمكم + +579 +00:45:15,660 --> 00:45:20,020 +انتوا تمام و أي فصلاللي بعدين بيصير عندى ال table + +580 +00:45:20,020 --> 00:45:23,220 +of contents خلصنا أول صفحة في الصفحة التانية إيش + +581 +00:45:23,220 --> 00:45:29,800 +بعمل ال table of contents ال table of contents + +582 +00:45:29,800 --> 00:45:34,340 +يعني جدول المحتويات جدول المحتويات بنعمله بآخر إشي + +583 +00:45:34,340 --> 00:45:39,240 +طيب و أنا هارجيكم كمان كيف ممكن نسوي بنتركنا + +584 +00:45:39,240 --> 00:45:42,540 +صفحتان أول ما بنسوي بنكتب شغلة اسمة introduction + +585 +00:45:42,540 --> 00:45:44,760 +المقدمة + +586 +00:45:45,900 --> 00:45:50,300 +صفحة التالتة هاي ال introduction ال introduction + +587 +00:45:50,300 --> 00:45:54,960 +بتاخد heading one بتاخد ايش heading one يعني بتاخد + +588 +00:45:54,960 --> 00:45:58,460 +العنوان الرئيسي فعشان بتاخد heading one بنروح على + +589 +00:45:58,460 --> 00:46:04,740 +شايفين هان heading one هاي heading one طبعا تنسوش + +590 +00:46:04,740 --> 00:46:11,900 +ان انتوا تعملوا ترقيم للصفحات تنسوش طبعا هاي عملنا + +591 +00:46:11,900 --> 00:46:16,560 +ترقيم للصفحات بنرجع للصفحة رقم اتنينارجعوا على + +592 +00:46:16,560 --> 00:46:21,300 +صفحة 2 و بنحط اللي هو ال table of contents صفحة + +593 +00:46:21,300 --> 00:46:29,680 +التانية بنروح نحكي reference تمام و بنروح شايفين + +594 +00:46:29,680 --> 00:46:33,000 +ال table of contents و بنعمل click عليه نختار أي + +595 +00:46:33,000 --> 00:46:36,220 +style احنا بعجبنا و نروح و نقوله okay فهي كتب ال + +596 +00:46:36,220 --> 00:46:42,060 +introduction صفحة 3 شايفينها يعني مابديش انا اتكتب + +597 +00:46:42,950 --> 00:46:46,610 +يعني manual خلاص automatically هلأ إيش الموضوع أنا + +598 +00:46:46,610 --> 00:46:49,770 +كتبنا بال introduction يعني كتبنا ال introduction + +599 +00:46:49,770 --> 00:46:52,490 +ال introduction إيش بدنا نكتب فيها ال introduction + +600 +00:46:52,490 --> 00:46:56,970 +بدك تكتب فيها what are you going to do إيش أنت + +601 +00:46:56,970 --> 00:47:04,930 +هتسوي بالراحة okay هلأ في الصفحة التانية حكينا + +602 +00:47:04,930 --> 00:47:07,870 +الصفحة الأولى your details الصفحة التانية بدنا + +603 +00:47:07,870 --> 00:47:10,790 +نحكي عن ال table of contents بنروح على references + +604 +00:47:10,790 --> 00:47:11,690 +زي ما تشايفها + +605 +00:47:16,870 --> 00:47:23,590 +مش مشكلة بنروح على table of contents في عندك زي ما + +606 +00:47:23,590 --> 00:47:27,050 +انت شايفه فيه many styles ال styles اللي بيعجبكم + +607 +00:47:27,050 --> 00:47:33,190 +بيختاروه فبنروح عاش بنحط نعمل click بيجي لبعد نحن + +608 +00:47:33,190 --> 00:47:38,070 +نخلص كل الشغل تبعنا بس نعمل update fieldبس هيغير + +609 +00:47:38,070 --> 00:47:43,410 +وي .. طيب هلأ ايش ال introduction ايش بتشمل؟ طبعا + +610 +00:47:43,410 --> 00:47:46,210 +ال introduction عادة تكتب أخرش لكن احنا بدنا + +611 +00:47:46,210 --> 00:47:49,430 +نكتبها بحيث نورجيكوا ايش ال introduction what you + +612 +00:47:49,430 --> 00:47:53,890 +are going to do مثلا + +613 +00:47:53,890 --> 00:48:00,770 +بنقول this assignment aims + +614 +00:48:00,770 --> 00:48:08,490 +to explainأول جملة هي أهم جملة أنتوا بتحطوها أهم + +615 +00:48:08,490 --> 00:48:11,590 +جملة أن أنتوا بتسوها this assignment aims to + +616 +00:48:11,590 --> 00:48:15,750 +explain the behavioral finance or the trading + +617 +00:48:15,750 --> 00:48:20,070 +mechanisms خلنا ناخد سؤال the trading mechanisms + +618 +00:48:20,070 --> 00:48:25,430 +أي سؤال بتكون إياه mechanisms and the market + +619 +00:48:25,430 --> 00:48:26,870 +participants + +620 +00:48:30,480 --> 00:48:35,680 +طيب هلا احنا حطينا اول جملة هذه ال key idea تبعتنا + +621 +00:48:35,680 --> 00:48:38,840 +طيب ال training mechanisms what it means training + +622 +00:48:38,840 --> 00:48:41,320 +mechanisms فبنبدأ نكتب okay the training + +623 +00:48:41,320 --> 00:48:48,680 +mechanisms means + +624 +00:48:48,680 --> 00:48:52,580 +that و بتبدو تعرفوا ايش ال training mechanisms + +625 +00:48:52,580 --> 00:48:57,300 +خلصنا خلصنا ال paragraph هذي بنروح بنحكي ايش + +626 +00:48:57,300 --> 00:49:00,340 +ضايقنا نحكي عن market participantsthe market + +627 +00:49:00,340 --> 00:49:04,260 +participants includes + +628 +00:49:04,260 --> 00:49:09,800 +okay و بتبدأ تحكي عن market participants خلصنا + +629 +00:49:09,800 --> 00:49:16,920 +بنجور this assignment is + +630 +00:49:16,920 --> 00:49:18,560 +structured as follows + +631 +00:49:23,250 --> 00:49:27,250 +ماذا يعني structured يعني منظم كالتالي section one + +632 +00:49:27,250 --> 00:49:29,290 +talk about this section two talk about this + +633 +00:49:29,290 --> 00:49:33,070 +section three and the conclusion خلصنا يعني البخرة + +634 +00:49:33,070 --> 00:49:37,550 +ال introduction فاهم كل شي he or she doesn't need + +635 +00:49:37,550 --> 00:49:44,350 +to go to read your assignments هلأ نيجي نحكي نكمل + +636 +00:49:44,350 --> 00:49:47,730 +خلصنا ال introduction نحكي section one مثلا اللي + +637 +00:49:47,730 --> 00:49:50,210 +هو behavioral or trading mechanisms + +638 +00:49:55,310 --> 00:49:59,610 +طبعا trading mechanisms كله ورا بعض ال trading + +639 +00:49:59,610 --> 00:50:05,690 +mechanisms هذي هذي heading هذي head و هذي ايش head + +640 +00:50:05,690 --> 00:50:09,130 +بتاخد heading one تروحوا على heading one و اقبلها + +641 +00:50:09,130 --> 00:50:12,450 +heading لو احنا طلعنا فوق طلعنا فوق و عملنا + +642 +00:50:12,450 --> 00:50:19,330 +updates okay update لل table update into our table + +643 +00:50:19,330 --> 00:50:25,470 +هنجد ان ال trading mechanisms انتحطتOkay فاللأ + +644 +00:50:25,470 --> 00:50:29,810 +حكينا عن trading mechanisms لجينا أنه في trading + +645 +00:50:29,810 --> 00:50:35,110 +mechanisms عرفناها وحكينا فلان بيحكي trading + +646 +00:50:35,110 --> 00:50:40,410 +mechanism كذا و okay و .. و trading mechanism تشمل + +647 +00:50:40,410 --> 00:50:43,250 +عدة mechanisms لاحظين mechanisms يعني في كذا + +648 +00:50:43,250 --> 00:50:47,590 +mechanisms يعني مثلا ممكن نقول dealer market + +649 +00:50:50,590 --> 00:50:54,010 +طبعا ننساش ان احنا نرقم ال introduction بتاخد رقم + +650 +00:50:54,010 --> 00:50:59,130 +واحد شفتوا ال trading mechanism بتاخد رقم اتنين + +651 +00:50:59,130 --> 00:51:02,990 +اذا كان فرعي ال dealer market بتاخد two point one + +652 +00:51:02,990 --> 00:51:08,390 +و بتاخد heeding ايش heeding two منروح على heeding + +653 +00:51:08,390 --> 00:51:11,310 +one منروح على heeding two لو احنا روحنا على ال + +654 +00:51:11,310 --> 00:51:15,150 +table الموجود هنا نعمل update table هنلاقي انه + +655 +00:51:15,150 --> 00:51:19,650 +شوفوا كيف الترتيب صار heeding one صار heeding two + +656 +00:51:22,450 --> 00:51:26,910 +طبعا حكينا عن ال dealer market و كذا بعدين روح + +657 +00:51:26,910 --> 00:51:33,890 +نقاش في mechanism تاني اللي هو مثلا ال ACN's طبعا + +658 +00:51:33,890 --> 00:51:39,010 +ال ACN's ال electronic communication networks طبعا + +659 +00:51:39,010 --> 00:51:43,830 +بتاخد 2.2 مظبوط برضه بنعطيها heading 2 + +660 +00:51:48,320 --> 00:51:52,400 +لازم يكونوا متساوين يعني إذا أنت بتكتب في ال + +661 +00:51:52,400 --> 00:51:56,180 +dealer market مثلا عشر أسطور هديك تقريبا مش شرط + +662 +00:51:56,180 --> 00:52:00,700 +تقريبا تسعة عشرة أو أحداشر أه اللي يكون فيه توازن + +663 +00:52:00,700 --> 00:52:04,950 +بال ..تقارب لو رجعنا كمان على هنا هنلاقي ايش + +664 +00:52:04,950 --> 00:52:10,470 +update و هنلاقي ايش 2.2 طيب خلصنا نحكي عن trading + +665 +00:52:10,470 --> 00:52:13,470 +mechanisms نروح نحكي عن اللي هو market + +666 +00:52:13,470 --> 00:52:16,610 +participants شوفتوا كيف احنا زي ما حكيت ال main + +667 +00:52:16,610 --> 00:52:19,950 +ideas مرتبطة فيها مافيش اشي يعني مابنحكيش اشي برا + +668 +00:52:19,950 --> 00:52:25,570 +الموضوع نحكي مثلا على market participants market + +669 +00:52:25,570 --> 00:52:27,870 +participants + +670 +00:52:31,710 --> 00:52:40,090 +هذه هتاخد تلاتة صح هتاخد تلاتة هتاخد Heading 1 هاي + +671 +00:52:40,090 --> 00:52:46,470 +Heading 1 تمام Heading 1 حكينا عن ال market .. + +672 +00:52:46,470 --> 00:52:48,730 +أعرفنا ال market participants و أعرفنا مين هم + +673 +00:52:48,730 --> 00:52:51,990 +فنيجي نحكي الأنواع و مين هم ال market participants + +674 +00:52:51,990 --> 00:52:56,890 +ممكن نقول مثلا ال three نيجي نحكي اللي هو ال + +675 +00:52:56,890 --> 00:52:57,230 +investors + +676 +00:53:00,560 --> 00:53:07,840 +مثلا و بنحكي عن ال investors مثلا mutual funds و + +677 +00:53:07,840 --> 00:53:11,460 +بنحكي عن ال mutual funds ال investors بنحطها + +678 +00:53:11,460 --> 00:53:17,800 +heeding 2 تمام و ها دي heeding 2 تمام و ها دي + +679 +00:53:17,800 --> 00:53:25,800 +بتكون 3.1 و ها دي 3.2 okay + +680 +00:53:25,800 --> 00:53:35,280 +و جينا بنعمل updateلل table شوفوا كيف مرتب الاشي + +681 +00:53:35,280 --> 00:53:40,360 +هك شايفين كيف مرتب introduction ماضحة انا لما بطلع + +682 +00:53:40,360 --> 00:53:43,820 +ال table of contents انا بقدر اقيم شغلك من اول + +683 +00:53:43,820 --> 00:53:47,660 +صفحة من اول صفحة اقدر اعرف you are you are doing + +684 +00:53:47,660 --> 00:53:51,400 +well ولا you are just rushing your assignments طب + +685 +00:53:51,400 --> 00:53:54,080 +انا هذا بس اذكركم انه انا هذا ال assignment كان + +686 +00:53:54,080 --> 00:53:57,200 +مطلوب منكم من شهرين زمان صح او يعني about three + +687 +00:53:57,200 --> 00:54:05,150 +months من تلت شهورمش .. مش هذه المشكلة المشكلة أنه + +688 +00:54:05,150 --> 00:54:08,350 +لو أنت قرأت في دقيقة أقل شيء أنه كان عندك .. موجود + +689 +00:54:08,350 --> 00:54:13,290 +عندك شغلة تكتب فيها لأن ال writing تيجي أخر إشي + +690 +00:54:13,290 --> 00:54:15,530 +أول شي بيكون فيه reading و بعدين بندخل على ال + +691 +00:54:15,530 --> 00:54:18,170 +writing طبعا هذا ال first step + +692 +00:54:21,240 --> 00:54:25,020 +فخلصنا بيصير انه احنا بدنا نشوف موضوعنا trading + +693 +00:54:25,020 --> 00:54:28,780 +mechanisms in Palestine Stock Exchange مش هيك + +694 +00:54:28,780 --> 00:54:32,940 +سؤالنا خلصنا market participants خلصنا كذا بالظبط + +695 +00:54:32,940 --> 00:54:35,960 +بعدين بيحكي على اللي هو بدنا نعرف ايش ال trading + +696 +00:54:35,960 --> 00:54:38,600 +mechanisms اللي متعاملوا فيها مثلا Palestine Stock + +697 +00:54:38,600 --> 00:54:39,140 +Exchange + +698 +00:54:45,700 --> 00:54:52,400 +هذه باريس تاينس توك إكشنج هتاخد heading one و رقم + +699 +00:54:52,400 --> 00:54:57,640 +تلاتة و رقم أربعة زي ما انتوا بتكونوا لإن هذه + +700 +00:54:57,640 --> 00:55:01,060 +هتكون ACN's + +701 +00:55:01,060 --> 00:55:02,940 +هنعمل control X + +702 +00:55:09,170 --> 00:55:12,090 +نفس الشغل هنحكي في Palestine Stock Exchange + +703 +00:55:12,090 --> 00:55:16,730 +موضوعين إيش هم ال trading mechanisms اللي بتبقى و + +704 +00:55:16,730 --> 00:55:22,870 +market participants هيكون عندى 4.1 و 4.2 هنيجي + +705 +00:55:22,870 --> 00:55:32,370 +نعرف اللي هو BSC ال trading mechanisms تمام + +706 +00:55:32,370 --> 00:55:36,770 +و عندنا اللي هو market participants بس هذا المطلوب + +707 +00:55:36,770 --> 00:55:37,090 +مننا + +708 +00:55:42,640 --> 00:55:49,020 +Okay فبنيجي هنا منروح + +709 +00:55:49,020 --> 00:55:53,440 +هنا طبعا heading heading 2 هذا heading 2 وهذا + +710 +00:55:53,440 --> 00:55:58,540 +heading 2 okay الأخر + +711 +00:55:58,540 --> 00:56:04,280 +إشي بعد ما خلصنا الكلام هذا نكتب ال conclusion هاي + +712 +00:56:04,280 --> 00:56:07,460 +ال conclusion رقم 5 بتاخد صح conclusion + +713 +00:56:10,830 --> 00:56:16,110 +Okay ال conclusion نحطها heading ham و هرجع + +714 +00:56:16,110 --> 00:56:20,710 +أحكيلكوا إيش ال conclusion بس الصبر يا باشا ال + +715 +00:56:20,710 --> 00:56:23,790 +conclusion خلصنا ال conclusion نحط إيش ال + +716 +00:56:23,790 --> 00:56:28,950 +references ال references و إذا كان في عندي + +717 +00:56:28,950 --> 00:56:32,470 +appendix بحط ال appendix هاي ال references و بنروح + +718 +00:56:32,470 --> 00:56:34,730 +نحط نعطيها heading طبعا ماترقموهاش ال references + +719 +00:56:34,730 --> 00:56:39,110 +بتترقمش لإن هي مش جزء من ال .. اه فلو روحنا احنا + +720 +00:56:39,110 --> 00:56:40,050 +عملنا updates + +721 +00:56:43,250 --> 00:56:47,050 +updates هاي هي ال assignment تبعنا شايفينه يعني + +722 +00:56:47,050 --> 00:56:53,970 +نكمل لكم إياها شويه هيك شوفوا + +723 +00:56:53,970 --> 00:57:01,250 +كيف يعني professional هاي + +724 +00:57:01,250 --> 00:57:08,440 +إيش رأيكم يعني ممكن تصور جنبه احناأي introduction, + +725 +00:57:09,580 --> 00:57:12,640 +trading mechanisms, dealers و ال conclusion نيجي + +726 +00:57:12,640 --> 00:57:16,620 +نحكي أخر شيء بعدين طلعوا يا بنات يا بنات انتبهوا + +727 +00:57:16,620 --> 00:57:22,600 +هان لو روحنا احنا على view روحنا على document map + +728 +00:57:22,600 --> 00:57:25,860 +هاي ال document map تبعتنا فانا بدل ما أروح أدور + +729 +00:57:25,860 --> 00:57:28,580 +في الصفحة وين بدأ أروح بدأ أروح مثلا أقرأ في ال + +730 +00:57:28,580 --> 00:57:31,280 +conclusion بروح بعمل tick على ال conclusion و بروح + +731 +00:57:31,280 --> 00:57:37,620 +أشوفه طيب ال conclusion إيش هي؟كيف نعملها؟ طيب، + +732 +00:57:37,620 --> 00:57:42,980 +هلأ بتروحي على view و بتروحي على view و بتحطي على + +733 +00:57:42,980 --> 00:57:47,020 +document map تحطي على document map و إيجدكي على + +734 +00:57:47,020 --> 00:57:52,480 +الشمال طبعا بال version تبع العشرة أجمل شوية + +735 +00:57:52,480 --> 00:57:55,980 +بيعطيكي document map بطريقة مرتبة و رائعة كتير + +736 +00:57:55,980 --> 00:58:00,630 +okayفالا بدك تروح مثلا على market participants + +737 +00:58:00,630 --> 00:58:03,790 +justic، بدك تروح على ال conclusion justic on the + +738 +00:58:03,790 --> 00:58:07,730 +conclusion، أسهل يعني تصور إن عندك مثلا خمسمية + +739 +00:58:07,730 --> 00:58:10,250 +صفحة، بدك يبقى عندك خمسمية صفحة، بدك تروح على + +740 +00:58:10,250 --> 00:58:15,010 +خمسمية صفحة، okay؟ بعدين conclusion، ال conclusion + +741 +00:58:15,010 --> 00:58:18,210 +إيش هي؟ هي ال introduction لكن بتعملوها + +742 +00:58:18,210 --> 00:58:22,470 +paraphrase، that's itعملولها paraphrase يعني عيدوا + +743 +00:58:22,470 --> 00:58:27,990 +صياغة ال introduction يعني ممكن انتوا اذا احنا + +744 +00:58:27,990 --> 00:58:31,110 +بدأنا من a to z يعني مثلا من ال introduction + +745 +00:58:31,110 --> 00:58:36,050 +اقبلوا من z to a فهمتوا؟ بالعكس؟ اه اقبلوا بالعكس + +746 +00:58:36,050 --> 00:58:40,150 +يعني نفسها يعني تحكوش اشي بال conclusion انتوا + +747 +00:58:40,150 --> 00:58:49,290 +ماحكتوش عنه نهائي احكوا شغلات مكتوبة عنهاو الله ب + +748 +00:58:49,290 --> 00:58:52,690 +conclusion ناسقته و لكن الباحث يارا كذا كذا طب انت + +749 +00:58:52,690 --> 00:58:56,350 +حكيت في الكلام هذا داخل ال lesson و ماحكيتش طبعا + +750 +00:58:56,350 --> 00:59:03,970 +فهذا اللي انا اللي هدب بسريع كيف احنا نكتب ال + +751 +00:59:03,970 --> 00:59:08,950 +introduction و كيف نتعامل معها طبعا هذه احنا بنقول + +752 +00:59:08,950 --> 00:59:14,490 +مش كتير يعني تفصيلية لكن على الأقل على مستواكوا + +753 +00:59:14,490 --> 00:59:15,770 +يعني بتساعدكوا + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/np_37KBtGH8_postprocess.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/np_37KBtGH8_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..25c1b57a4431fe562b03770d9a5b944d07e3220d --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/np_37KBtGH8_postprocess.srt @@ -0,0 +1,1868 @@ +1 +00:00:21,430 --> 00:00:26,450 +بسم الله الرحمن الرحيم ال .. ال .. الأسبوع الماضي + +2 +00:00:26,450 --> 00:00:31,690 +حكينا بال .. بال money markets instruments بال + +3 +00:00:31,690 --> 00:00:35,090 +money market instruments اليوم بدنا نحكي على ال + +4 +00:00:35,090 --> 00:00:38,190 +yield for the money market instruments يعني العائد + +5 +00:00:38,190 --> 00:00:41,350 +اللي ممكن نحصل عليه بال money market instruments و + +6 +00:00:41,350 --> 00:00:44,170 +كمان نحكي بال capital markets يعني هنا في هدفين + +7 +00:00:44,170 --> 00:00:48,410 +اليوم الهدف الأول ان احنا to show the yield of the + +8 +00:00:48,410 --> 00:00:51,460 +money markets ال yield يعني العائدوالهدف التاني + +9 +00:00:51,460 --> 00:00:54,420 +لدخل في موضوع الجديد اللي هو اسمه capital markets + +10 +00:00:54,420 --> 00:01:04,220 +اللي هو أسواق رأس المال طبعا طيب نحاول بس نذكركم + +11 +00:01:04,220 --> 00:01:06,920 +بال money market securities زي ما أنتوا شايفين + +12 +00:01:06,920 --> 00:01:10,340 +حكينا عن treasury bills اللي هو دولات الخزينة + +13 +00:01:10,340 --> 00:01:12,880 +للناس اللي ماكانوش حاضرين okay + +14 +00:01:14,890 --> 00:01:22,090 +و يجب أن تعرف بيد و أسك بريس و تقرأ بيد و أسك بريس + +15 +00:01:22,090 --> 00:01:30,670 +و تعرف كيف تستطيع تغيير من تسكوت إلى نظام بريس لأن + +16 +00:01:30,670 --> 00:01:34,080 +في الوالد ستريتيعني wall street اللي هي المكان + +17 +00:01:34,080 --> 00:01:37,780 +اللي بيظهروا فيه أسعار ال treasury bills or from + +18 +00:01:37,780 --> 00:01:40,800 +the dealers they cannot show you the prices + +19 +00:01:40,800 --> 00:01:44,840 +بورجونات ال prices بورجونات ال discount rates okay + +20 +00:01:44,840 --> 00:01:48,240 +so you should know how to convert the discount + +21 +00:01:48,240 --> 00:01:52,000 +rate into the prices certificate of dom visit اللي + +22 +00:01:52,000 --> 00:01:55,900 +هو شهادات الإيداع ال commercial paper اللي هو + +23 +00:01:55,900 --> 00:02:00,200 +أوراق التجاريةbankers acceptance اللي هو القبولات + +24 +00:02:00,200 --> 00:02:03,240 +المصرفية وحكينا أن القبولات المصرفية بتكون ناتجة + +25 +00:02:03,240 --> 00:02:07,200 +عن عملية التجارة الدولية okay بين المصدر و بين + +26 +00:02:07,200 --> 00:02:10,740 +المستورد و ال bankers acceptance تستخدم كأدام + +27 +00:02:10,740 --> 00:02:13,760 +الأدوات الاستثمارية ال euro dollars حكينا ال euro + +28 +00:02:13,760 --> 00:02:17,520 +dollars اللي هي ال dollar outside the united + +29 +00:02:17,520 --> 00:02:20,960 +states و they trade on the euro dollar because it + +30 +00:02:21,120 --> 00:02:24,660 +has higher rate than the on-site United States، + +31 +00:02:24,660 --> 00:02:28,900 +إلها عوائد أعلى من ما لو كانت داخل الولايات + +32 +00:02:28,900 --> 00:02:32,500 +المتحدة، حكينا عن ال repos و ال reverses اللي هو + +33 +00:02:32,500 --> 00:02:38,580 +اتفاقية إعادة الشراء و طريقة العكسية + +34 +00:02:39,920 --> 00:02:43,000 +فحكينا على ال federal funds أن البنوك التجارية + +35 +00:02:43,000 --> 00:02:46,340 +بتكون محتفظة لدى البنك المركزي في حسابات حسابات + +36 +00:02:46,340 --> 00:02:49,260 +ممكن تكون فائض ممكن تكون عاجز وبالتالي يتم احتساب + +37 +00:02:49,260 --> 00:02:52,800 +ال federal funds حسب الفائض و العاجز كمان ملاحظة + +38 +00:02:52,800 --> 00:02:56,140 +مهمة أن ال federal funds rate is using as a + +39 +00:02:56,140 --> 00:03:02,250 +monetary policy يستخدم كسياسة نقديةso increase the + +40 +00:03:02,250 --> 00:03:05,750 +federal + +41 +00:03:05,750 --> 00:03:11,650 +fund rates it means motivating banks to keep more + +42 +00:03:11,650 --> 00:03:16,870 +funds in the central bank بيخليهم إنه يحتفظوا أكتر + +43 +00:03:16,870 --> 00:03:20,970 +من بلغ لدى البنك المركزي and in this the central + +44 +00:03:20,970 --> 00:03:25,390 +bank absorbing the inflation rates بيحاول إنه يخفض + +45 +00:03:25,390 --> 00:03:28,370 +من معدلات التدخم okay + +46 +00:03:30,820 --> 00:03:35,800 +هلا نحكي عن ال yields on market instruments ال + +47 +00:03:35,800 --> 00:03:40,320 +yield العائد زي ما حكينا ان العائد لازم يكون + +48 +00:03:40,320 --> 00:03:48,200 +انعكاس ل risk and return risk and return بدنا نعرف + +49 +00:03:48,200 --> 00:03:54,440 +which instrument has lower rate of return and + +50 +00:03:54,440 --> 00:03:58,950 +which instrument has higher rate of returnال + +51 +00:03:58,950 --> 00:04:04,290 +treasury bills تعتبر risk free it has the least + +52 +00:04:04,290 --> 00:04:09,230 +return and the least risk يعني تعتبر أقل مخاطر + +53 +00:04:09,230 --> 00:04:14,590 +وتعتبر أقل عائد ف treasury bills treasury bills هي + +54 +00:04:14,590 --> 00:04:18,850 +فيها risk free إيش يعني risk free risk free it + +55 +00:04:18,850 --> 00:04:20,950 +means خالية من المخاطر + +56 +00:04:24,190 --> 00:04:26,990 +because it's guaranteed from the .. from the + +57 +00:04:26,990 --> 00:04:30,030 +central bank or from .. from the governments محمية + +58 +00:04:30,030 --> 00:04:32,230 +من ال .. is protected by the governments محمية من + +59 +00:04:32,230 --> 00:04:35,690 +الحكومة okay and there is no default risk default + +60 +00:04:35,690 --> 00:04:39,110 +risk يعني مخاطر عدم السداد مافيشش مخاطر عدم السداد + +61 +00:04:39,110 --> 00:04:41,510 +الحكومة guaranteed the government is guaranteed to + +62 +00:04:41,510 --> 00:04:49,110 +pay back the treasury bills okay بعدين بيجي مثلا + +63 +00:04:49,110 --> 00:04:52,410 +ال CDs عارفين ال CDs اللي هو certificate of + +64 +00:04:52,410 --> 00:04:57,030 +depositOkay بعدين بيجي ال commercial paper اللي هو + +65 +00:04:57,030 --> 00:05:03,430 +الأوراق التجارية بعدين بيجي عندنا اللي هو ال + +66 +00:05:03,430 --> 00:05:08,270 +repurchase agreement agreement وننساش أنه in + +67 +00:05:08,270 --> 00:05:10,930 +between ممكن ييجي اللي هو ال bankers acceptance + +68 +00:05:10,930 --> 00:05:15,590 +bankers acceptance عارفين ال bankers acceptance + +69 +00:05:15,590 --> 00:05:20,370 +اللي هو القبولات المصرفية معناه الكلام is زي ما + +70 +00:05:20,370 --> 00:05:24,870 +انتوا شايفين زي ما انتوا شايفين على ال ..زي ما + +71 +00:05:24,870 --> 00:05:32,410 +انتوا شايفين هاد ال area هاد + +72 +00:05:32,410 --> 00:05:38,110 +ال area شايفينها المنطقة هادى منطقة تتميز بان + +73 +00:05:38,110 --> 00:05:43,250 +مخاطرها منخفضة okay وعائدها منخفض لان قبل قليل + +74 +00:05:43,250 --> 00:05:45,930 +هنحكي بال capital market ال capital market + +75 +00:05:45,930 --> 00:05:50,810 +starting from this from here it includes higher + +76 +00:05:50,810 --> 00:05:55,330 +risk and higher returnفهذه introduction عشان نحكي + +77 +00:05:55,330 --> 00:05:59,150 +بال .. بال capital market اذا again كل ما احنا + +78 +00:05:59,150 --> 00:06:03,610 +بنزيد العائد هتزيد المخاطر يعني زي ما انتوا شايفين + +79 +00:06:03,610 --> 00:06:07,410 +يعني مثلا ال commercial paper العائد بتاعها شوفوا + +80 +00:06:07,410 --> 00:06:14,750 +العائد العائد هيه أعلى من ال treasury bills هال + +81 +00:06:14,750 --> 00:06:18,570 +treasury bills وهي ال .. ال .. ال commercial paper + +82 +00:06:18,570 --> 00:06:24,100 +ليش؟ لأن مخاطرها أعلىفكويس يعني مثلا زي ما هانال + +83 +00:06:24,100 --> 00:06:26,260 +أخت سألت إيش ممكن يكون فيه أسئلة في الامتحانات + +84 +00:06:26,260 --> 00:06:31,820 +ممكن نسأل انه which security hold higher rate of + +85 +00:06:31,820 --> 00:06:38,200 +return and why for instance if we say about if we + +86 +00:06:38,200 --> 00:06:44,860 +talk about the the CDs why CDs has lower rate of + +87 +00:06:44,860 --> 00:06:48,520 +return than the repurchase agreement for instance + +88 +00:06:51,360 --> 00:06:56,940 +لأ ليش هي أقل مخاطر أقل مخاطر ممكن نحكي لو ال + +89 +00:06:56,940 --> 00:07:01,580 +return ما هو ليش لو ال return و ليش عائد مخفض if + +90 +00:07:01,580 --> 00:07:05,220 +you read between lines إذا بتفرقوا بين السطور إن + +91 +00:07:05,220 --> 00:07:09,220 +ال .. ال CDs is backed by the .. by the central + +92 +00:07:09,220 --> 00:07:12,580 +bank or by .. by the government or backed by the + +93 +00:07:12,580 --> 00:07:17,340 +.. the banks يعني محمية من قبل البنوك طب why the + +94 +00:07:17,340 --> 00:07:22,460 +treasury bills؟has risk free comparing with the + +95 +00:07:22,460 --> 00:07:27,060 +commercial paper ليش ال treasury bills مخاطرها أقل + +96 +00:07:27,060 --> 00:07:30,560 +من ال commercial paper من من من ال governments + +97 +00:07:30,560 --> 00:07:33,700 +because it's guaranteed by the governments and it + +98 +00:07:33,700 --> 00:07:38,120 +has default free default risk ماعليهاش مخاطر دي + +99 +00:07:38,120 --> 00:07:41,960 +عدم استداد okay يعني هاي المواضيع اللي احنا we can + +100 +00:07:41,960 --> 00:07:48,000 +ask around this طيب + +101 +00:07:53,310 --> 00:07:56,490 +نحكي على the .. the .. the capital markets نيجي + +102 +00:07:56,490 --> 00:08:01,850 +نحكي على ال capital markets the capital markets we + +103 +00:08:01,850 --> 00:08:04,510 +classify the capital market in the chapter one + +104 +00:08:04,510 --> 00:08:13,010 +into three main markets bond market okay or let's + +105 +00:08:13,010 --> 00:08:17,390 +say equity markets, debit markets and derivatives + +106 +00:08:17,390 --> 00:08:20,330 +هم الذاكرين لما حكينا الأسواق رأس المال اللي لها + +107 +00:08:20,330 --> 00:08:27,160 +تلت أنواعdebt market أسواق الديون equity market و + +108 +00:08:27,160 --> 00:08:30,000 +ال derivatives هدول التلات أنواع من اللي أكتبلكم + +109 +00:08:30,000 --> 00:08:35,720 +بيهم كمان مرة بس للتسجيل ال + +110 +00:08:35,720 --> 00:08:41,560 +capital market هي .. فينا تلات أنواع debts هي أقل + +111 +00:08:41,560 --> 00:08:49,340 +مخاطر بعدين عندنا ال equity مخاطرها أعلى شوية و + +112 +00:08:49,340 --> 00:08:51,700 +بعدين أخر إشي اللي هو ال derivatives + +113 +00:08:55,270 --> 00:08:57,650 +طبعا ال derivatives عارفين هال derivatives اللي هو + +114 +00:08:57,650 --> 00:09:02,430 +الاش المشتقات طبعا المشتقات زى ما أنتوا شايفين + +115 +00:09:02,430 --> 00:09:07,210 +أعلى مقاطر مقارنة مع ال debts market ومقارنة مع ال + +116 +00:09:07,210 --> 00:09:14,550 +equity market هنبدأ نحكي بال debts markets هنبدأ + +117 +00:09:14,550 --> 00:09:17,030 +نعمل classifications لل debts market ال debts + +118 +00:09:17,030 --> 00:09:19,370 +markets أهم سوق في ال debts markets هو ال bond + +119 +00:09:19,370 --> 00:09:23,450 +marketsيعني لو جينا هنا ال debt market اهم the + +120 +00:09:23,450 --> 00:09:27,170 +most important market in the debt market is the + +121 +00:09:27,170 --> 00:09:35,430 +bond market سوق السندات يعني مثلا خينا نرجع + +122 +00:09:35,430 --> 00:09:46,270 +للميزانية العامة balance of sheets لأي شركة هاي + +123 +00:09:46,270 --> 00:09:49,090 +ال assets و هاي ال liabilities + +124 +00:09:52,160 --> 00:09:56,920 +Okay هذا المكان هو ال current assets هنا وهنا + +125 +00:09:56,920 --> 00:10:00,100 +current liabilities current assets وهنا current + +126 +00:10:00,100 --> 00:10:06,160 +liabilities هنا fixed assets okay + +127 +00:10:06,160 --> 00:10:14,460 +وهنا في شغلتين long term liabilities okay + +128 +00:10:14,460 --> 00:10:18,740 +long term liabilities وعندي اللي هو ايش ال equity + +129 +00:10:22,500 --> 00:10:28,100 +Equity and shareholder ال current assets is funded + +130 +00:10:28,100 --> 00:10:31,280 +by the current liabilities يعني احنا ال current + +131 +00:10:31,280 --> 00:10:34,120 +assets الأصول المتداولة بنموّلها من وين؟ من الأصول + +132 +00:10:34,120 --> 00:10:37,720 +.. من ال .. من الاتزامات المتداولة ال fixed assets + +133 +00:10:37,720 --> 00:10:41,120 +ال machines و ال equipments بنموّلهم من وين؟ + +134 +00:10:41,120 --> 00:10:46,020 +بنموّلهم من جانبين من ال long term liabilities and + +135 +00:10:46,020 --> 00:10:50,740 +equity ال bonds market is located under long term + +136 +00:10:50,740 --> 00:10:54,840 +liabilitiesال long term زي ما أخدته بال accounting + +137 +00:10:54,840 --> 00:10:58,940 +في المحاسبة يعني أنا مثلا بدي أعمل expansion + +138 +00:10:58,940 --> 00:11:01,740 +عارفين شو معنى expansion؟ expansion يعني أعمل توسع + +139 +00:11:01,740 --> 00:11:06,780 +أمامي خيارين يا إما أنا بستخدم ديون يا إما بستخدم + +140 +00:11:06,780 --> 00:11:09,540 +حقوق ملكية يعني مصدر أسهم أو بعمل mixing between + +141 +00:11:09,540 --> 00:11:14,640 +them أو بعمل خلط من أتهم يعني مثلا ال expansion + +142 +00:11:14,640 --> 00:11:17,640 +بيكلفني مليون دولار بدي أعمل هنا expansion مثلا + +143 +00:11:17,640 --> 00:11:23,790 +بدي أشتري new machines بيكلفني مثلا مليون دولاربدي + +144 +00:11:23,790 --> 00:11:27,150 +one million one million ممكن احكي انه half million + +145 +00:11:27,150 --> 00:11:30,450 +five hundred thousands from the long term + +146 +00:11:30,450 --> 00:11:33,830 +liabilities and the rest from equity يعني خمسمية + +147 +00:11:33,830 --> 00:11:36,770 +اخدها من ال debts و خمسمية اخدها من ايه من ال + +148 +00:11:36,770 --> 00:11:41,070 +equity طب الخمسمية how we can use the five hundred + +149 +00:11:41,070 --> 00:11:44,450 +او how we can get the five hundred we can issue + +150 +00:11:44,450 --> 00:11:50,270 +bonds ممكن نصدر سندات okay يعني كمان مرة انه انا + +151 +00:11:50,270 --> 00:11:54,460 +بحتاج expansionI need one million بحتاج one + +152 +00:11:54,460 --> 00:11:58,680 +million so I have two options use the long term + +153 +00:11:58,680 --> 00:12:02,120 +liabilities or equity or mixing between them يا + +154 +00:12:02,120 --> 00:12:05,800 +أما بستخدم هذي يا هذي يا أما ب .. بعمل خلط من أتم + +155 +00:12:05,800 --> 00:12:09,180 +so for instance we decide to issue five hundred + +156 +00:12:09,180 --> 00:12:14,260 +thousands by using bonds أصدر سندات إنه بدأ أنا + +157 +00:12:14,260 --> 00:12:20,520 +أمول المشروع نص المشروع بالدانيأدى مثلا من الbank + +158 +00:12:20,520 --> 00:12:23,880 +أو أعمل مرابحة أو الطريقة اللى .. اللى بتناسبني + +159 +00:12:23,880 --> 00:12:29,260 +اللى أصدر سندات فى حد عرف ال .. السندات قبلهاك + +160 +00:12:29,260 --> 00:12:34,140 +أكيد إيش what it means bonds اتفضلى اللى هو .. + +161 +00:12:34,140 --> 00:12:38,940 +الشخص ما بيبقى السندات اللى هو ال game طبعا ادت .. + +162 +00:12:38,940 --> 00:12:41,720 +ادت .. طبعا ادت .. طبعا ادت .. طبعا ادت .. طبعا + +163 +00:12:41,720 --> 00:12:42,300 +ادت .. طبعا ادت .. طبعا ادت .. طبعا ادت .. طبعا + +164 +00:12:42,300 --> 00:12:42,600 +ادت .. طبعا ادت .. طبعا ادت .. طبعا ادت .. طبعا + +165 +00:12:42,600 --> 00:12:47,620 +ادت .. طبعا ادت .. طبعا ادت .. طبعا ادت .. طب + +166 +00:12:51,190 --> 00:12:57,350 +المدة هاي كام هتكون احتمالها؟ سنة طب إذا شو الفرق + +167 +00:12:57,350 --> 00:13:00,890 +بين ال money market وبين capital market if you + +168 +00:13:00,890 --> 00:13:05,180 +save one year؟فبتصير money market في الحالة دي صح؟ + +169 +00:13:05,180 --> 00:13:09,320 +so it is greater than one year هي أكتر من سنة ممكن + +170 +00:13:09,320 --> 00:13:12,780 +تصل عشر سنين ممكن تصل تلاتين سنة في موعد استحقاق + +171 +00:13:12,780 --> 00:13:17,840 +السنة في موعد استحقاق انا بتدفع ألف و مئة سنة أنا + +172 +00:13:17,840 --> 00:13:23,170 +أخدت بألفيعني حسب نسبة .. كاملة مش مشكلة .. انا + +173 +00:13:23,170 --> 00:13:29,190 +بنفعه بالنسبة للزيادة فمصدر الصناد بكون استفاد من + +174 +00:13:29,190 --> 00:13:36,370 +الصناد اللي هو .. مصدر الصناد؟ ايوة ال investor مش + +175 +00:13:36,370 --> 00:13:38,970 +مصدر الصناد المصدر الصناد هو بصدر الصناد عشان يخسر + +176 +00:13:38,970 --> 00:13:45,310 +على الفلوس ايوة الوضع الطبيعي ان انا امول الأصول + +177 +00:13:45,310 --> 00:13:49,530 +المتداولة من الخصوم المتداولةمظبوط؟ مظبوط الان + +178 +00:13:49,530 --> 00:13:52,850 +بالنسبة لتعوين المحاسبة بيحكوا انه انا الأصول + +179 +00:13:52,850 --> 00:13:56,490 +متداولة مثلا عندي مخزون المخزون انا بدأ اموّل + +180 +00:13:56,490 --> 00:13:59,650 +مخزون يعني بدأ انا اشري مخزون المخزون وين؟ أصول + +181 +00:13:59,650 --> 00:14:03,570 +متداولة ولا أصول ثابتة أصول متداولة بسألك انت + +182 +00:14:03,570 --> 00:14:07,770 +متداولة متداولة اه الاصول المتداولة أمامي خيارين + +183 +00:14:07,770 --> 00:14:11,950 +يا اما انا اموّلها من أصول من خصوم متداولة اللي هو + +184 +00:14:11,950 --> 00:14:15,620 +الاتزامات زي ما انت شايفهامن الجانب هذا او من + +185 +00:14:15,620 --> 00:14:20,360 +الجانب هذا اللي هو الثابتة من الاتزامات طويلة + +186 +00:14:20,360 --> 00:14:24,560 +الأجل طبعا مش منطق انا اروح مخزون امول من أصول او + +187 +00:14:24,560 --> 00:14:29,320 +من الاتزامات طويلة الأجل يعني مانفعش مثلا انا بدى + +188 +00:14:29,320 --> 00:14:34,160 +اشري مخزون اروح اصدر سندات مانفع فبروح انا ايش من + +189 +00:14:34,160 --> 00:14:39,920 +الاتزامات متداولة okay طيبهذه الاتزانات المتداولة + +190 +00:14:39,920 --> 00:14:44,020 +ايش الأسواق بتاعتها اللي حكيناها الأسبوع الفاتر و + +191 +00:14:44,020 --> 00:14:48,900 +أعطيناك مقدمة عن الأسبوع هذا اللي هي عندك ال + +192 +00:14:48,900 --> 00:14:51,740 +commercial paper ممكن نصدر commercial paper okay + +193 +00:14:51,740 --> 00:14:56,700 +ممكن bankers acceptance إذا موجودة عندنا هاي ال .. + +194 +00:14:56,700 --> 00:15:00,920 +الوسائل في الخصوم المتداولة هاي بيسموها ال + +195 +00:15:00,920 --> 00:15:04,160 +matching أنه أنا بدير الأصول المتداولة من الخصوم + +196 +00:15:04,160 --> 00:15:08,660 +المتداولةنيجي نحكي على الأصول الثابتة هان، لما أنا + +197 +00:15:08,660 --> 00:15:12,340 +بدي أشري مكان، machines و equipments، من وين بدي + +198 +00:15:12,340 --> 00:15:15,980 +أشريهم؟ + +199 +00:15:15,980 --> 00:15:20,860 +أنا لما بدي أشري مكينة، من وين بدي أشري المكينة؟ + +200 +00:15:20,860 --> 00:15:26,160 +مصادر التمويل، إيش أنواع مصادر التمويل؟ طويلة و + +201 +00:15:26,160 --> 00:15:28,500 +قصيرة الأجل، إيش القصير الأجل؟ + +202 +00:15:34,250 --> 00:15:36,910 +قصيرة الأجل ايش و هي؟ القروض قصيرة الأجل اللي هي + +203 +00:15:36,910 --> 00:15:39,250 +موجودة في ال money market ولا ال capital market؟ + +204 +00:15:39,250 --> 00:15:41,270 +لأ في ال money market في ال money market طيب خلينا + +205 +00:15:41,270 --> 00:15:43,550 +نركز بال capital market ايش عندنا option بال + +206 +00:15:43,550 --> 00:15:46,250 +capital market؟ ايش في عندنا خيارات بال capital + +207 +00:15:46,250 --> 00:15:50,710 +market؟ السندات لإن انت قلت انه ممكن تكون عشر سنين + +208 +00:15:50,710 --> 00:15:54,930 +عشرين سنة okay سندات و ايش كمان؟ غير السندات + +209 +00:15:58,620 --> 00:16:02,160 +إيش غير السندات؟ إحنا حكينا في عندنا ممكن يكون + +210 +00:16:02,160 --> 00:16:06,100 +سوقين هاي الموجودين اللي عندك في عندك شغلتين long + +211 +00:16:06,100 --> 00:16:10,760 +term liabilities و .. و .. و كمان شغلة لأ اجريها + +212 +00:16:10,760 --> 00:16:16,640 +منيح equity ايش يعني equity؟ معناه حقوق ملكية + +213 +00:16:16,640 --> 00:16:20,740 +طبعا؟ فأنا يا أما بستخدم ال long term liabilities + +214 +00:16:20,740 --> 00:16:24,700 +اللي هو الديون طوية للأجن أو بستخدم حقوق ملكية ال + +215 +00:16:24,700 --> 00:16:29,120 +long term liabilities أي سوقها ده سوق سنداتطبعا؟ + +216 +00:16:29,120 --> 00:16:32,320 +فعلى سوق السندات اللي هو the .. the bond market + +217 +00:16:32,320 --> 00:16:38,000 +كيف أنا بطرح السندات؟ أنا واضح للكلام؟ فهمت + +218 +00:16:38,000 --> 00:16:42,180 +الخريطة هذه؟ مين مش فاهمها؟ الخريطة .. هذه الخريطة + +219 +00:16:43,130 --> 00:16:45,850 +طب هلا وصلنا لعند ال bond market اللي هو أسواق + +220 +00:16:45,850 --> 00:16:49,530 +سندات طوية الأجل بدأ أصدر سند كيف قالية إصدار + +221 +00:16:49,530 --> 00:16:52,810 +السند قالية إصدار السند إن الشركة قررت هان كام + +222 +00:16:52,810 --> 00:16:58,790 +تصدر 500 ألف دولار محتاجة لمليون لتعمل توسع 500 + +223 +00:16:58,790 --> 00:17:04,870 +ألف هتكون ديون و 500 ألف هتكون equity طب كيف يتم + +224 +00:17:04,870 --> 00:17:08,870 +إصدار السند إصدار السند خليني أبص لحظة إصدار السند + +225 +00:17:08,870 --> 00:17:11,210 +بيكون + +226 +00:17:13,760 --> 00:17:20,660 +هذا هو سند السند فيه له bar value يكون له قيمة + +227 +00:17:20,660 --> 00:17:27,260 +اسمية القيمة الاسمية مثلا ممكن يكون الف دولار يعني + +228 +00:17:27,260 --> 00:17:29,880 +إذا كان القيمة الاسمية الف دولار أكم سند لازم أصدر + +229 +00:17:29,880 --> 00:17:34,360 +خليني أعينك السؤال إذا كان القيمة الاسمية للسند + +230 +00:17:34,360 --> 00:17:38,200 +أنا محتاج لخمسمية ألف دولار إذا كان القيمة الاسمية + +231 +00:17:38,200 --> 00:17:41,860 +للسند الف دولار أكم سند لازم أصدر لأ هي خليها + +232 +00:17:43,260 --> 00:17:49,320 +رياضية بسيطة إذا كان قيمة السند ألف دولار و أنا + +233 +00:17:49,320 --> 00:17:54,380 +محتاج خمسمية ألف دولار أكم سند لازم أصدر؟ خمسمية + +234 +00:17:54,380 --> 00:17:59,600 +إذا لازم أصدر خمسمية سند طيب هل ال bar value + +235 +00:17:59,600 --> 00:18:02,880 +واضحة؟ ميت ألف ال bar value فيه كمان شغل لازم + +236 +00:18:02,880 --> 00:18:07,740 +نعرفها اللي هو ال coupon rate coupon rate إيش ال + +237 +00:18:07,740 --> 00:18:12,150 +coupon rate؟ اللي هو الفائدة الكوبونيةالـ + +238 +00:18:12,150 --> 00:18:19,070 +corporate rate نفترض 8% ايش يعني 8%؟ كل سنة حامل + +239 +00:18:19,070 --> 00:18:22,610 +السند اللي هو ال investor اللي بديش للسند لازم + +240 +00:18:22,610 --> 00:18:28,170 +يحصل 8% على قيمة السند كل نهاية السند كل نهاية + +241 +00:18:28,170 --> 00:18:31,490 +السنة بديه يحصل على 8% مقابل ان هو ايش حصل على + +242 +00:18:31,490 --> 00:18:35,770 +السند بعدين في عندنا شغلة اسمها maturity dates + +243 +00:18:36,820 --> 00:18:41,060 +التاريخ الاستحقاق اليوم احنا في سنة 2013 نفترض انه + +244 +00:18:41,060 --> 00:18:51,260 +يبدو ي 31 12 2023 يعني تقريبا اننا حوالي عشر سنوات + +245 +00:18:51,260 --> 00:18:56,420 +عم بالسند كل سنة ال investor حامل السند هيحصل على + +246 +00:18:56,420 --> 00:19:02,580 +كام؟ هيحصل على 8% من قيمة السندطبعا في سندات .. في + +247 +00:19:02,580 --> 00:19:08,740 +سندات بتدفع annual interest فائدة سنوية و في سندات + +248 +00:19:08,740 --> 00:19:14,700 +بتدفع semi-annual اللي هو نصف سنوية يعني لما تكون + +249 +00:19:14,700 --> 00:19:17,240 +نصف سنوية تمانية في المية كدهش ندفع كل ست شهور + +250 +00:19:17,240 --> 00:19:24,920 +اربعة في المية okay طيب هلأ فهمتي هذا السند كيف + +251 +00:19:24,920 --> 00:19:26,040 +يتم التعامل فيه؟ + +252 +00:19:33,710 --> 00:19:38,290 +تم إصدار السند من قبل نفطرة شركة من الشركات مثلا + +253 +00:19:38,290 --> 00:19:46,110 +شركة Badico Badico محتاجة هذا التمويل الشركة + +254 +00:19:46,110 --> 00:19:50,350 +الفلسطينية طبعا هذه أصدرت السند تم إصدار السند + +255 +00:19:50,350 --> 00:19:55,650 +السند هلأ وين بروح؟ على ال financial markets حكينا + +256 +00:19:55,650 --> 00:19:59,490 +إنه مملوع إن الشركات تتعامل مباشرة مع ال + +257 +00:19:59,490 --> 00:20:02,190 +individuals مع ال investors لازم يكون وين؟ إيش في + +258 +00:20:02,190 --> 00:20:06,390 +النص؟financial intermediaries او dealers بروحوا + +259 +00:20:06,390 --> 00:20:08,510 +طبعا ال financial market اللي هم عندنا ال dealers + +260 +00:20:08,510 --> 00:20:15,330 +and they market this بسوقوه ببيعوه في السوق بيجي + +261 +00:20:15,330 --> 00:20:19,350 +ال investors هاي ال investors okay بيجي ال + +262 +00:20:19,350 --> 00:20:23,830 +investors بشتريوا السندات بدفعوا كام كام لازم + +263 +00:20:23,830 --> 00:20:27,820 +يدفعوا ال investorsبيدفعوا ألف دولار قيمة السند + +264 +00:20:27,820 --> 00:20:33,100 +بيدفعوا ال bar value لحظوا + +265 +00:20:33,100 --> 00:20:38,060 +هنا pay to mean to the pedico بدفعوا يعني خلّيني + +266 +00:20:38,060 --> 00:20:44,920 +نمشي مع السهم بدفعوا ل pedico ألف دولار ضرب خمس + +267 +00:20:44,920 --> 00:20:50,160 +مائة خمس مائة سند احنا + +268 +00:20:50,160 --> 00:20:54,590 +بنطرحه في السوق okay و بنشوف مين بدي يشتريحسب + +269 +00:20:54,590 --> 00:20:59,210 +الطلبة نفترض إنه احنا كنا حظنا منيح و تم بيع + +270 +00:20:59,210 --> 00:21:03,730 +الإصدار ف 500 سنة أتبيعناهم في الف هي ال 500 ألف + +271 +00:21:03,730 --> 00:21:08,950 +أخدناهم طبعا ال dealer هياخد عمولة بسيطة مقابل هو + +272 +00:21:08,950 --> 00:21:15,830 +marketing the bonds مقابل أنه سوق السندات خلصنا ال + +273 +00:21:15,830 --> 00:21:21,550 +process هذا طيب هلأ badico كل نهاية السنة إيش راح + +274 +00:21:21,550 --> 00:21:25,680 +تدفع؟هتدفع اللي هو ال fixed income اللي هو ان + +275 +00:21:25,680 --> 00:21:31,120 +الفائدة هيلاحظوا تمانية في المية ضرب ال bar value + +276 +00:21:31,120 --> 00:21:35,980 +ال bar value كام؟ الف هتدفعها لل investors شوفوا + +277 +00:21:35,980 --> 00:21:44,400 +اتجاه السهم الفائدة + +278 +00:21:44,400 --> 00:21:47,900 +اللي هي تمانية في المية هي ال corporate rates ضرب + +279 +00:21:47,900 --> 00:21:51,320 +الألف دولار ال bar value اخدوا اللي هو عندكم + +280 +00:21:51,320 --> 00:21:54,250 +تمانية في المية ضرب الف كام؟تمانين دولار اه + +281 +00:21:54,250 --> 00:21:58,930 +فهياخدوا تمانين دولار قانى و لا هادى اذا كانت سيمي + +282 +00:21:58,930 --> 00:22:03,650 +قانى و لا هاياخدوا اربعين دولار كل ست شهور تنزل في + +283 +00:22:03,650 --> 00:22:09,170 +حسابهم في البنك طيب + +284 +00:22:09,170 --> 00:22:15,630 +بعد هيك هيصير بال + +285 +00:22:15,630 --> 00:22:18,470 +الفين و تلاتة و عشر عشر هيصير هذا كل سنة هيصير اه + +286 +00:22:24,360 --> 00:22:33,600 +هذا السهم 8% دفعنا لل industry السهم هذا هذول + +287 +00:22:33,600 --> 00:22:36,080 +اللي بندفعه هذول الفلوس هندفعه من خلال ال dealer + +288 +00:22:36,080 --> 00:22:39,960 +يعني فيه برنامج وسيط يعني ال medical هتدفع لل + +289 +00:22:39,960 --> 00:22:43,660 +dealer و ال dealer يروح يدفع لمين لل industry + +290 +00:22:47,550 --> 00:22:51,750 +طيب هذا .. هذا كل سنة هيصير في سنة الـ 2023 إيش + +291 +00:22:51,750 --> 00:22:54,750 +راح يصير؟ في واحة وتلاتين واطمعاش تلاتة وعشرين إيش + +292 +00:22:54,750 --> 00:23:00,090 +راح يصير؟ اللي هو إيش بيسميه matured to date؟ إيش + +293 +00:23:00,090 --> 00:23:07,810 +راح يصير في تاريخ الاستحقاق؟ أه؟ مين اللي هيحصل؟ + +294 +00:23:07,810 --> 00:23:11,970 +حامل السند، بالضبط حامل السند حامل السند في سنة ال + +295 +00:23:11,970 --> 00:23:15,590 +2023 وواحدة تلاتين واطمعاش هتروح الشركة تدفعله + +296 +00:23:15,590 --> 00:23:20,310 +قيمة السند بالكاملاللي هي كام؟ اللي هو الألف دولار + +297 +00:23:20,310 --> 00:23:23,990 +طبعا ألف دولار ضال بالخمسمية اللي هو بيصير خمسمية + +298 +00:23:23,990 --> 00:23:30,570 +خمسمية ألف طبعا يعني بالمجموع لو طلعته المجموع هان + +299 +00:23:30,570 --> 00:23:35,310 +بالمجموع ال investor هيحصل عشان أو تان هياخد اللي + +300 +00:23:35,310 --> 00:23:41,730 +هو ال coupon rate و ال principal ايش ال principal + +301 +00:23:41,730 --> 00:23:46,470 +معناها؟أيوة بالظبط المصاري الأصليين اللي دفعوا + +302 +00:23:46,470 --> 00:23:53,550 +الألف دولار هياخد هاتين تان واحد تان لأ + +303 +00:23:53,550 --> 00:23:57,030 +هذا في أنواع سندات مختلفة خلينا نراكز على المفهوم + +304 +00:23:57,030 --> 00:24:06,710 +واضح واضح ال chart هذا انو انت + +305 +00:24:06,710 --> 00:24:11,430 +تتبعي هذا طلع كام دفع هو اليوم ألف دولار دفعهم + +306 +00:24:11,430 --> 00:24:11,730 +اليوم + +307 +00:24:15,840 --> 00:24:22,600 +لأ 8% هذه فائدة بس ربح له بس أما الألف دولار اللي + +308 +00:24:22,600 --> 00:24:27,640 +هو المبلغ اللي أصلا دفعه في 2013 هياخده بال 2023 + +309 +00:24:27,640 --> 00:24:32,260 +فاستفاد هو إيش؟ استفاد اللي هو 8% اللي هتيجيله كل + +310 +00:24:32,260 --> 00:24:38,380 +.. كل .. كل سنة هذا ال process تبع السند واضح + +311 +00:24:38,380 --> 00:24:43,530 +عندك؟ الجانب هذا البنات الوراأكيد البنات اللي جانب + +312 +00:24:43,530 --> 00:24:51,770 +هذا وضع عندكم سند أه هذا + +313 +00:24:51,770 --> 00:24:55,810 +كتير في أسلة متعلقة في ال .. في هذا الرسم يعني ال + +314 +00:24:55,810 --> 00:25:00,490 +investors إيش بيستفيد ال + +315 +00:25:00,490 --> 00:25:05,550 +principle الفائدة أساسا تمام؟ + +316 +00:25:10,920 --> 00:25:14,520 +طب هذا بالنسبة للشركات هذه الشركات بتصدر سندات + +317 +00:25:14,520 --> 00:25:18,780 +بنفس الطريقة الحكومة بتصدر كمان سندات اللي احنا + +318 +00:25:18,780 --> 00:25:22,740 +هنبدأ فيها هذا اسمه corporate bonds هذا الكلام + +319 +00:25:22,740 --> 00:25:26,680 +الشرحناه اسمه corporate bonds اللي هو سندات + +320 +00:25:26,680 --> 00:25:36,240 +للشركات corporate بنفس + +321 +00:25:36,240 --> 00:25:39,540 +الطريقة احنا بنصدر الحكومة بتصدر ال government + +322 +00:25:39,540 --> 00:25:39,960 +bonds + +323 +00:25:46,610 --> 00:25:52,130 +و ال government bond فيه نوعين اذا هذا اللي شرحناه + +324 +00:25:52,130 --> 00:25:54,830 +اسمه corporate bonds اللي هو سندات الشركات الشركات + +325 +00:25:54,830 --> 00:25:58,710 +لما بدأت مايول مشاريعها تصدر corporate bonds اللي + +326 +00:25:58,710 --> 00:26:04,350 +هو سندات الشركات وبنفس الطريقة الحكومة بتصدر اللي + +327 +00:26:04,350 --> 00:26:11,070 +هو سندات الحكومة طب لأ السندات الحكومية بتختلف عن + +328 +00:26:11,070 --> 00:26:14,710 +ال treasury bills زي ما أنا حكت البنت انه السندات + +329 +00:26:14,710 --> 00:26:21,520 +الحكومية هي طويلة أجلإيش معلها طويلة أجل حكينا ال + +330 +00:26:21,520 --> 00:26:25,780 +treasury bills هي تمويل حكومي لكن قصير أجل ال + +331 +00:26:25,780 --> 00:26:29,800 +treasury notes صح اه ال treasury notes إذا كان + +332 +00:26:29,800 --> 00:26:35,220 +treasury notes و عنده treasury bonds في عنده نوعين + +333 +00:26:35,220 --> 00:26:40,180 +treasury notes ال government bonds بتقسمها نوعين + +334 +00:26:40,180 --> 00:26:46,660 +treasury notes و treasury bonds و في أنواع أخرى + +335 +00:26:46,660 --> 00:26:52,720 +متعلقةبطريقة غير مباشرة بال government bonds بس + +336 +00:26:52,720 --> 00:26:55,940 +هدول هما النوعين الرئيسيين اللي هو treasury notes + +337 +00:26:55,940 --> 00:27:01,900 +و ال treasury bonds في عندنا سندات أخرى مرتبطة + +338 +00:27:01,900 --> 00:27:07,840 +بطريقة غير مباشرة و هم عندنا مثلا اللي لهم ارتباط + +339 +00:27:07,840 --> 00:27:11,580 +غير مباشر اللي هو ال municipal bonds municipal + +340 +00:27:11,580 --> 00:27:16,100 +bonds عارفين إيش معنا municipal bonds اللي هو + +341 +00:27:16,100 --> 00:27:21,160 +سندات البلدياتيعني مثلا بلدية غزة بدت .. بدت تشري + +342 +00:27:21,160 --> 00:27:24,700 +جرفات و تشري أدوات و كذا طويلة أجال فبتصدر شغل + +343 +00:27:24,700 --> 00:27:29,840 +اسمه municipal bonds اللي هو سندات بلدية طبعا؟ طيب + +344 +00:27:29,840 --> 00:27:39,480 +في كمان عندنا شغل اسمه revenue bonds revenue سندات + +345 +00:27:39,480 --> 00:27:44,040 +بتولد عائد طبعا هذه برضه اللي هي علاقة بطريقة غير + +346 +00:27:44,040 --> 00:27:47,480 +مباشرة بالحكومة يعني الحكومة مثلا بتعمل مشروع + +347 +00:27:48,140 --> 00:27:52,300 +والمشروع هذا بيعطي عوائد حكومة مش شركة طب تصدر + +348 +00:27:52,300 --> 00:27:57,000 +شغلة اسمها revenue bond طب في كمان شغلة تالتة + +349 +00:27:57,000 --> 00:28:07,900 +اسمها industrial bonds اه سندات صناعية industrial + +350 +00:28:07,900 --> 00:28:13,880 +bonds سندات صناعية طبعا هذا كله موجود عندكم + +351 +00:28:13,880 --> 00:28:16,440 +بالكتاب بصفحه + +352 +00:28:26,080 --> 00:28:29,800 +بصفحة زي ما حكت هان صفحة اربعة و تلاتين و خمس و + +353 +00:28:29,800 --> 00:28:37,180 +تلاتين و صفحة ستة و تلاتين okay + +354 +00:28:37,180 --> 00:28:41,680 +طيب + +355 +00:28:41,680 --> 00:28:44,800 +هلا بالنسبة لل industrial bonds خليني بس نعطيكم + +356 +00:28:44,800 --> 00:28:49,840 +municipal هذا + +357 +00:28:51,640 --> 00:28:55,860 +هذا ال treasury notes اللي هو بيسموها سندات خزينة + +358 +00:28:55,860 --> 00:29:03,060 +هنيجي نحكي في التفصيل فيها سندات خزينة treasury + +359 +00:29:03,060 --> 00:29:09,300 +notes notes مش معناها notes الملاحظات لأ يعني + +360 +00:29:09,300 --> 00:29:16,760 +سندات خزينة و + +361 +00:29:16,760 --> 00:29:20,640 +هنيجي نفرق بينال treasury notes وال treasury bonds + +362 +00:29:20,640 --> 00:29:23,100 +يعني الفرق بين ال treasury notes وال treasury + +363 +00:29:23,100 --> 00:29:28,200 +bonds الفرق بسيط كتير بيناتهم هنيجي نحكي فيه زي ما + +364 +00:29:28,200 --> 00:29:31,900 +حكت هان اللي هو الفترة الزمنية خليني نرجع هان ال + +365 +00:29:31,900 --> 00:29:35,800 +corporate bonds حكيناها اللي هو الشركات تصدرهيعني + +366 +00:29:35,800 --> 00:29:40,040 +ال government bonds أو سندات الحكومة كتير فيها + +367 +00:29:40,040 --> 00:29:43,500 +شغلات يعني كتير فيها أنواع يعني ممكن نحكي عن + +368 +00:29:43,500 --> 00:29:47,000 +تلاتين اربعين خمسين نوع من أنواع سندات الحكومة بس + +369 +00:29:47,000 --> 00:29:49,300 +بدنا نحكي الشائع اللي هو treasury notes و treasury + +370 +00:29:49,300 --> 00:29:54,400 +bonds ال treasury notes اللي هي سندات تعتبر سندات + +371 +00:29:54,400 --> 00:29:57,960 +خزينة لكن طويلة أجل و treasury bonds سندات خزينة + +372 +00:29:57,960 --> 00:30:03,760 +أقل مش قصيرة أجل يعني أقل من ال treasury bondsأقل + +373 +00:30:03,760 --> 00:30:09,300 +من ال trigger notes يعني متوسطة okay هلأ في أنواع + +374 +00:30:09,300 --> 00:30:13,320 +أخرى اللي حكينا فيها انه هي ارتباطها ارتباط غير + +375 +00:30:13,320 --> 00:30:18,540 +مباشر مع الحكومة يعني بتم إصدارها من مؤسسات شبه + +376 +00:30:18,540 --> 00:30:24,200 +حكومية يعني زي مثلا البلديات لأ ال municipal bonds + +377 +00:30:24,200 --> 00:30:27,860 +اللي هو البلدية لما بدها تيجي تعمل توسع بدها تشتري + +378 +00:30:27,860 --> 00:30:33,780 +مثلا جرفات بتعمل مشاريع فبتستخدمأنواع من السندات + +379 +00:30:33,780 --> 00:30:37,740 +فى عندنا ال revenue bonds اللى هو سندات الإيرادات + +380 +00:30:37,740 --> 00:30:43,160 +يعني بدهم يعملوا مشاريع استثمارية okay فيعني مثلا + +381 +00:30:43,160 --> 00:30:46,740 +بدهم يعملوا شاطق البحر و لما بيعملوا شاطق البحر + +382 +00:30:46,740 --> 00:30:50,440 +هذا هيصير فى عواقد عليها فبروحوا بصدر البلدية + +383 +00:30:50,440 --> 00:30:54,970 +بتصدر شغل اسمه revenue bondsطيب بال industrial + +384 +00:30:54,970 --> 00:31:00,110 +bonds مثلا بيعملوا بناطق صناعية فبتروح الحكومة أو + +385 +00:31:00,110 --> 00:31:03,470 +البلدية بتروح تصدر اللي هو ال industrial bonds + +386 +00:31:03,470 --> 00:31:08,310 +يعني بحيث مولق و يعملوا تشجيع للصناعة البنية + +387 +00:31:08,310 --> 00:31:11,590 +التحتية في الصناعة فهذه الأنواع اللي ممكن نحكي + +388 +00:31:11,590 --> 00:31:13,730 +فيها بال government bonds + +389 +00:31:17,410 --> 00:31:20,470 +Okay مش هنحكي كتير بال inflation protected + +390 +00:31:20,470 --> 00:31:23,210 +treasury bonds و مش هنحكي بال federal agency debts + +391 +00:31:23,210 --> 00:31:27,470 +يعني احنا هنركز في treasury notes and bonds okay + +392 +00:31:27,470 --> 00:31:33,130 +تركيزنا هيكون على treasury notes and bonds و هنحكي + +393 +00:31:33,130 --> 00:31:36,810 +شوية بال international bonds ال municipal bonds + +394 +00:31:36,810 --> 00:31:42,110 +حكيناها كويه هل هو السندات اللي تصدرها البلدية + +395 +00:31:43,230 --> 00:31:46,250 +طبعا؟ يعني زي مثلا بلدية شيكاجو مثلا، بلدية + +396 +00:31:46,250 --> 00:31:49,730 +نيويورك، بلدية لندن مثلا، زي بلدية غزة مثلا ممكن + +397 +00:31:49,730 --> 00:31:55,870 +تصدر، فهذه البلديات بدل ما هي تروح ت .. يعني مثلا + +398 +00:31:55,870 --> 00:32:03,110 +بتحصل على إعانات ومساعدات فتروح تصدر سنادات okay + +399 +00:32:03,110 --> 00:32:08,770 +طيب هلأ نيجي نحكي عن treasury notes and bonds هلو + +400 +00:32:08,770 --> 00:32:13,880 +نرجع ل treasury notes و treasury bondsتطلعوا على + +401 +00:32:13,880 --> 00:32:17,620 +ال treasury notes ال treasury notes up to ten + +402 +00:32:17,620 --> 00:32:24,180 +years أكتر من عشرة سنوات ال treasury bonds هي + +403 +00:32:24,180 --> 00:32:28,780 +matured from ten to thirty بس نصلح لك هنا ال + +404 +00:32:28,780 --> 00:32:32,860 +treasury bonds بتكون + +405 +00:32:32,860 --> 00:32:37,450 +فترة زمنية أطول من ال treasury notesأه يعني الفترة + +406 +00:32:37,450 --> 00:32:40,270 +الزمنية تلعب ال treasury notes هي عشر سنوات ten + +407 +00:32:40,270 --> 00:32:43,730 +years بينما ال treasury bonds هي بتمتد من عشر على + +408 +00:32:43,730 --> 00:32:48,730 +تلاتين سنة يعني ال notes اللي .. ايه بالظبط ال + +409 +00:32:48,730 --> 00:32:53,010 +notes treasury notes بس + +410 +00:32:53,010 --> 00:32:55,790 +هذا لا يعني أن ال bonds لها تم إصدارها بعشر سنوات + +411 +00:32:55,790 --> 00:32:59,750 +يعني هنا ال confusing بيصير أن ال treasury notes + +412 +00:32:59,750 --> 00:33:02,430 +ممكن تكون عشر سنوات و ال treasury bonds ممكن تكون + +413 +00:33:02,430 --> 00:33:05,820 +عشر سنواتلكن في إمكانية احنا ال treasury bonds + +414 +00:33:05,820 --> 00:33:09,840 +نصدرها أكتر من عشر سنوات لعشرين و تلاتين سنة زي + +415 +00:33:09,840 --> 00:33:15,320 +مثلا بدي أصدر .. بدي أصدر سندات لإنشاء مناطق + +416 +00:33:15,320 --> 00:33:21,360 +صناعية بالزمن مثلا عشرين و تلاتين سنة okay؟ بدي + +417 +00:33:21,360 --> 00:33:25,460 +أطور مثلا مناطق سياحية مثلا في .. في قطاع غزة أو + +418 +00:33:25,460 --> 00:33:28,420 +في .. في أي مكان في العالم فبيحتاج انه أكتر من عشر + +419 +00:33:28,420 --> 00:33:33,240 +سنواتOkay هذا الفرق اللى ممكن نحصل عليه بال + +420 +00:33:33,240 --> 00:33:36,740 +treasury notes و treasury bonds فرق تانى هنحكي فيه + +421 +00:33:36,740 --> 00:33:42,260 +كمان اللى هو ال taxable و ال non taxable انه فيه + +422 +00:33:42,260 --> 00:33:45,580 +عندنا سندات عشان اشجع انا المواطنين يشتريوا سندات + +423 +00:33:45,580 --> 00:33:51,000 +فممكن انا اعفيها من الضريبة عشان اشجع المواطن + +424 +00:33:51,000 --> 00:33:53,800 +يشتري او الشركات تشتري السندات فممكن اعفيها من + +425 +00:33:53,800 --> 00:33:59,460 +الضريبةطبعا هنحكي عن هذه الأنواع من السلدات اللي + +426 +00:33:59,460 --> 00:34:03,140 +ممكن احنا نعفيها من الضريبة اذا عندنا فارقين + +427 +00:34:03,140 --> 00:34:07,660 +الفارق الأساسي انه الفترة الزمنية و الفارق التاني + +428 +00:34:07,660 --> 00:34:10,640 +اذا كان taxable او non-taxable taxable يعني عليه + +429 +00:34:10,640 --> 00:34:14,760 +ضريبة non-taxable ماعليهوش ضريبة او مش معفي من + +430 +00:34:14,760 --> 00:34:18,940 +الضريبة عادة زي ما احنا شرحنا ال bar value بتكون + +431 +00:34:18,940 --> 00:34:23,330 +الف دولاربشكل عام السندات كلها سواء كانت corporate + +432 +00:34:23,330 --> 00:34:27,930 +bonds ولا كانت government bonds بتصدر في الف دولار + +433 +00:34:27,930 --> 00:34:30,870 +as a bar value طب خلينا نذكركم ال treasury bills + +434 +00:34:30,870 --> 00:34:34,370 +ايش ال bar value تبعتها عشر تلاف فإذا احنا ما + +435 +00:34:34,370 --> 00:34:37,930 +حكينالكم مش مثلا ال treasury bill هتعرفوا by + +436 +00:34:37,930 --> 00:34:43,180 +default ان ال treasury notesعفوا ال treasury bills + +437 +00:34:43,180 --> 00:34:47,040 +عشر تلاف و في ال money market أقل من سنة لكن ال + +438 +00:34:47,040 --> 00:34:49,340 +treasury notes و ال .. و ال government bonds و ال + +439 +00:34:49,340 --> 00:34:52,440 +corporate bonds هي one thousand دولار، الف دولار + +440 +00:34:52,440 --> 00:34:56,060 +هدول + +441 +00:34:56,060 --> 00:34:59,620 +لأ هدول مش money markets لأ ال money market + +442 +00:34:59,620 --> 00:35:03,490 +خلصناهمOkay ال money markets اللي هو ال commercial + +443 +00:35:03,490 --> 00:35:07,170 +paper و ال bankers acceptance و ال .. و ال + +444 +00:35:07,170 --> 00:35:13,530 +treasury bills و .. و ال CDs okay حكينا لكوا كمان + +445 +00:35:13,530 --> 00:35:16,610 +بال .. ال interest ممكن paid semiannually or + +446 +00:35:16,610 --> 00:35:21,190 +annually ممكن ندفعها annually or semiannual يعني + +447 +00:35:21,190 --> 00:35:26,960 +سنويا أو نصف سنويانجي على ال quota، ايش ال quota؟ + +448 +00:35:26,960 --> 00:35:30,840 +طريقة التسعير، حكينالكم ب treasury notes، ال + +449 +00:35:30,840 --> 00:35:35,240 +treasury bills، حكينا التسعير كيف بتم؟ كيف طريقة + +450 +00:35:35,240 --> 00:35:39,460 +التسعير بالتم؟ بال treasury bills، التسعير اللي + +451 +00:35:39,460 --> 00:35:44,400 +أعطيتكواياه في واجب، كيف طريقة التسعير؟ نسبة خاصة + +452 +00:35:46,390 --> 00:35:51,430 +percentage طبعا بالطريقة التسعير في ال corporate + +453 +00:35:51,430 --> 00:35:55,650 +bonds و بال government bonds بتختلف عن treasury + +454 +00:35:55,650 --> 00:36:02,510 +bills بتختلف بس بشغلة واحدة ان الأسعار المعرضة هي + +455 +00:36:02,510 --> 00:36:06,430 +as a percentage ايش يعني as a percentage لو احنا + +456 +00:36:06,430 --> 00:36:10,110 +فاكرين أخدنا ال bid و ال ask okay + +457 +00:36:12,500 --> 00:36:16,400 +يعني دقيقة بس دقيقة بس ال bid و ال ask ال bid و ال + +458 +00:36:16,400 --> 00:36:20,120 +ask في حالة ال corporate bonds و ال government + +459 +00:36:20,120 --> 00:36:23,860 +bonds بتعرض كنسبة مقوية من ال bar value مثلا لو + +460 +00:36:23,860 --> 00:36:30,400 +قلت 102 ايش يعني 102 يعني 102 في المية من قيمة ال + +461 +00:36:30,400 --> 00:36:35,220 +bar value يعني 102 في المية ضد ال bar value الألف + +462 +00:36:35,220 --> 00:36:43,450 +اللي هي بتطلع كام ألف و عشريناضرب 102% ضرب ال 1000 + +463 +00:36:43,450 --> 00:36:50,750 +شوف كده تطلع معاكم كام تطلع؟ طبعا فاللي احنا نريج + +464 +00:36:50,750 --> 00:36:57,550 +ال ask نفس الشغلاء ال ask لو كان 103 103% من ضرب + +465 +00:36:57,550 --> 00:37:02,290 +ال bar value 103% ضرب ال bar value ابنجف عند هذه + +466 +00:37:02,290 --> 00:37:08,070 +النقطة عشان اللقاء اللي جاي لنشوف كيف نسعراللي هو + +467 +00:37:08,070 --> 00:37:11,370 +ال bonds وكمل على هذا الموضوع، في حد عنده سؤال؟ + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/np_37KBtGH8_raw.json b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/np_37KBtGH8_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..0a1ae853646be7449f9762dc1f31290f9646200c --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/np_37KBtGH8_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4999, "start": 21.43, "end": 49.99, "text": "بسم الله الرحمن الرحيم ال .. ال .. الأسبوع الماضي حكينا بال .. بال money markets instruments بال money market instruments اليوم بدنا نحكي على ال yield for the money market instruments يعني العائد اللي ممكن نحصل عليه بال money 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instruments ال yield العائد زي ما حكينا ان العائد لازم يكون انعكاس ل risk and return risk and return بدنا نعرف which instrument has lower rate of return and which instrument has higher rate of return", "tokens": [3224, 15040, 8717, 5016, 4117, 1829, 18871, 2423, 32168, 322, 2142, 12190, 2423, 11257, 18863, 16373, 3215, 30767, 1829, 19446, 11331, 4117, 1829, 8315, 16472, 18863, 16373, 3215, 5296, 31377, 2304, 7251, 30544, 16472, 3615, 4117, 32277, 5296, 3148, 293, 2736, 3148, 293, 2736, 47525, 8315, 8717, 3615, 28480, 597, 7198, 575, 3126, 3314, 295, 2736, 293, 597, 7198, 575, 2946, 3314, 295, 2736], "avg_logprob": -0.1515625, "compression_ratio": 1.7261904761904763, "no_speech_prob": 0.0, "words": [{"start": 210.82, "end": 211.1, "word": "هلا", "probability": 0.4013671875}, {"start": 211.1, "end": 211.42, "word": " نحكي", "probability": 0.97216796875}, {"start": 211.42, "end": 211.6, "word": " عن", "probability": 0.98486328125}, {"start": 211.6, "end": 211.7, "word": " ال", 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\ No newline at end of file diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/p_HS3Q1jsnI.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/p_HS3Q1jsnI.srt new file mode 100644 index 0000000000000000000000000000000000000000..05a609854628aad85e6c363469402d9cf1f78bf5 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/p_HS3Q1jsnI.srt @@ -0,0 +1,1655 @@ +1 +00:00:21,630 --> 00:00:26,970 +بسم الله الرحمن الرحيم المرة الفاتتة احنا كنا نحكي + +2 +00:00:26,970 --> 00:00:32,870 +عن الـ margin الشغل بالهامش أنا هعيد الموضوع مع + +3 +00:00:32,870 --> 00:00:37,130 +إعطاء mathematical example + +4 +00:00:37,130 --> 00:00:43,790 +مع إعطاء أمثلة بحب أذكر أنه نهاية الشهر هو بيخلص + +5 +00:00:43,790 --> 00:00:48,080 +الـ ..الفترة الـ feedback للـ assignments بتاعتكم فإن + +6 +00:00:48,080 --> 00:00:53,540 +انتوا حاولوا تخلصوا الـ feedback تبع الـ assignment + +7 +00:00:53,540 --> 00:01:00,340 +إذا في يعني طالبات يعني مثلا انضغطوا أنا ممكن يعني + +8 +00:01:00,340 --> 00:01:05,800 +أعطي فرصة كمان أسبوع ممكن أعطي فرصة خليني بس أكمل + +9 +00:01:05,800 --> 00:01:09,740 +أحكي أنا هـ .. هعطي فرصة لمدة أسبوع بعد الـ .. بعد + +10 +00:01:09,740 --> 00:01:12,700 +الامتحانات بعد انتهاء الامتحانات بعد هيك مش هـ .. + +11 +00:01:13,570 --> 00:01:16,470 +ماشي بعطيكم أسبوع بعد الامتحانات بعد أسبوع واحد + +12 +00:01:16,470 --> 00:01:22,610 +بعد انتهاء الامتحانات okay okay لكن ما تعملوش delay + +13 +00:01:22,610 --> 00:01:30,010 +حتى نهاية الفصل okay نرجع ونحكي بالـ .. بالـ margin + +14 +00:01:30,010 --> 00:01:35,670 +إذا أنتم كنتوا تابعوا معايا في صفحة 76 في الكتاب + +15 +00:01:35,670 --> 00:01:41,270 +76 77 ناخد مثال احنا + +16 +00:01:41,270 --> 00:01:42,390 +حكينا الـ .. الـ margin + +17 +00:01:45,990 --> 00:01:51,430 +internal معناه حكينا احنا الـ .. الـ margin أن الـ .. + +18 +00:01:51,430 --> 00:01:56,130 +الـ investors open account of the .. the broker and + +19 +00:01:56,130 --> 00:01:59,610 +a portion of his account is funded by the investor + +20 +00:01:59,610 --> 00:02:03,090 +and the rest is funded by the broker يعني جزء من + +21 +00:02:03,090 --> 00:02:08,230 +الاستثمار بتم تغطيته من المستثمر و الجزء المتبقي + +22 +00:02:08,230 --> 00:02:14,590 +بتم تغطيته من الـ .. الـ dealer فنسبة مساهمة الـ + +23 +00:02:14,590 --> 00:02:20,680 +investor للـ total wealth لقيمة الثروة هو بيعتبر الـ + +24 +00:02:20,680 --> 00:02:24,600 +margin يعني لو احنا أخذنا مثال مثال بسيط زي ما هو + +25 +00:02:24,600 --> 00:02:28,880 +موجود عندكم بالكتاب لو + +26 +00:02:28,880 --> 00:02:32,280 +حكينا مثلا الـ assets الـ assets معناها قيمة + +27 +00:02:32,280 --> 00:02:37,960 +الاستثمار we started by ten thousands الـ $10,000 + +28 +00:02:37,960 --> 00:02:42,620 +دولار اللي هو زي ما كان مرفوعه مائة دولار الـ price + +29 +00:02:42,620 --> 00:02:48,600 +of the stock times one hundred dollar the number + +30 +00:02:48,600 --> 00:02:55,640 +of shares يعني المستثمر اشترى مائة سهم اشترى + +31 +00:02:55,640 --> 00:03:01,940 +مائة سهم خليني أوضحهم عندنا الـ price one hundred + +32 +00:03:02,940 --> 00:03:07,940 +number of shares is one hundred so the asset is + +33 +00:03:07,940 --> 00:03:16,680 +this times this one hundred ten + +34 +00:03:16,680 --> 00:03:17,240 +thousands + +35 +00:03:23,410 --> 00:03:29,130 +هذا مستثمر راح يشتري أسهم okay انتبهوا باسمعنا عن + +36 +00:03:29,130 --> 00:03:33,810 +المثال مستثمر راح يشتري مية سهم number of shares + +37 +00:03:33,810 --> 00:03:37,330 +one hundred shares the price at one hundred dollar + +38 +00:03:37,330 --> 00:03:41,530 +so the asset is ten thousands لأنه ضربنا المية + +39 +00:03:41,530 --> 00:03:46,910 +دولار في المية سهم قيمة الاستثمار ضروري تكون + +40 +00:03:46,910 --> 00:03:51,220 +معاكم الآلة الحاسبة عشان تتبعوا معايا طيب هلأ اللي + +41 +00:03:51,220 --> 00:03:56,540 +صار حكينا أنه the investors open a margin account + +42 +00:03:56,540 --> 00:04:02,700 +okay of the ten thousand he borrowed four + +43 +00:04:02,700 --> 00:04:06,700 +thousands okay + +44 +00:04:06,700 --> 00:04:16,300 +he borrows by loans و اقترض four thousands and the + +45 +00:04:16,300 --> 00:04:20,280 +rest is paid by himself والباقي كم؟ six thousands + +46 +00:04:20,280 --> 00:04:26,040 +equity is paid by them by him so the margin now + +47 +00:04:26,040 --> 00:04:32,180 +the margin as we explain the margin is the + +48 +00:04:32,180 --> 00:04:38,140 +percentage of the contribution of the investors to + +49 +00:04:38,140 --> 00:04:41,930 +the total wealth or to the total assets يعني + +50 +00:04:41,930 --> 00:04:45,810 +بالعربي أنه هي قيمة الـ contribution اللي هو + +51 +00:04:45,810 --> 00:04:49,370 +المساهمة بتاعة الـ investor على قيمة الاستثمار الكل + +52 +00:04:49,370 --> 00:04:56,230 +هاي بيسميها إيش الـ margin الـ margin واضح حكيناها + +53 +00:04:56,230 --> 00:05:00,010 +المرة الثلاثة فبالتالي + +54 +00:05:00,010 --> 00:05:04,090 +الـ margin اللي هي كام مساهمة الـ investors ست آلاف + +55 +00:05:04,090 --> 00:05:08,290 +ست آلاف so six thousands divided by ten thousands + +56 +00:05:10,360 --> 00:05:20,060 +so it is sixty percent is it right okay لحد + +57 +00:05:20,060 --> 00:05:25,020 +اللحظة تكون فاهم يعني so + +58 +00:05:25,020 --> 00:05:28,720 +the sixty percent خلينا نفترض أنه the prices is + +59 +00:05:28,720 --> 00:05:33,420 +going down احنا بنحاول أنه ناخد the worst case أنه + +60 +00:05:33,420 --> 00:05:38,630 +أسوأ الظروف when the prices go down the margin is + +61 +00:05:38,630 --> 00:05:41,850 +also go down كمان الـ margin بنزل خلينا نشوف الـ + +62 +00:05:41,850 --> 00:05:44,810 +price one hundred خلينا نخليها ثمانين eighty + +63 +00:05:44,810 --> 00:05:48,250 +hundred .. eighty dollar the price was one hundred + +64 +00:05:48,250 --> 00:05:50,810 +and now is eighty dollar so the price is going + +65 +00:05:50,810 --> 00:05:55,090 +down the number of shares so the assets how much + +66 +00:05:56,420 --> 00:06:00,700 +أنتوا دايرين الـ assets eight thousands right of them + +67 +00:06:00,700 --> 00:06:04,160 +four thousands لون القروي الـ violate لإنه احنا + +68 +00:06:04,160 --> 00:06:08,120 +مااخذنا قرض من الـ .. and the rest is four thousands + +69 +00:06:08,120 --> 00:06:17,840 +so what is the margin now احنا + +70 +00:06:17,840 --> 00:06:20,560 +المرة الفاتتة احنا حكينا الكلام هذا بس يعني I'm + +71 +00:06:20,560 --> 00:06:26,330 +just repeating this احنا الـ price تمانين دولار وعدد + +72 +00:06:26,330 --> 00:06:29,030 +الأسهم اللي بيشتريهم 100 دولار ما بتغيروش مين اللي بتغير + +73 +00:06:29,030 --> 00:06:34,670 +بس الـ price يا الـ price يا بينزل يا بيطلع معليش أيش + +74 +00:06:34,670 --> 00:06:37,830 +.. هيأثر .. هيأثر على الـ assets وهيأثر على الـ + +75 +00:06:37,830 --> 00:06:41,830 +equity وهيأثر على الـ margin طبعا ارجع لتعريف + +76 +00:06:41,830 --> 00:06:44,410 +المحاضرة الفاتتة الـ margin هو نسبة مساهمة الـ + +77 +00:06:44,410 --> 00:06:48,950 +investor على الـ total wealth طيب هلأ قد ايش الـ + +78 +00:06:48,950 --> 00:06:54,110 +margin الـ margin fifty percent من وين جبناها + +79 +00:06:54,110 --> 00:06:59,230 +اللي .. اللي هي الـ 4000 بتاعة الـ loan الـ + +80 +00:06:59,230 --> 00:07:02,470 +4000 بتاعة الـ equity على الـ 8000 بتاعة الـ assets + +81 +00:07:02,470 --> 00:07:09,450 +نروح كمان السعر نزل وأكثر من هيك 70$ شو أنتم + +82 +00:07:09,450 --> 00:07:14,110 +بتلاحظوا بالـ .. بالـ equity أن واحد الزنا بيخسر + +83 +00:07:14,110 --> 00:07:20,690 +قد ايش خسر من .. من لما نزل .. 2000$ خسر طب هلأ أروح + +84 +00:07:20,690 --> 00:07:25,620 +كمان قد ايش حيصير هون seven thousands and here three + +85 +00:07:25,620 --> 00:07:31,740 +thousands and here is four thousands and now اه + +86 +00:07:31,740 --> 00:07:37,160 +sorry yes so here four thousands and three + +87 +00:07:37,160 --> 00:07:41,380 +thousands forty + +88 +00:07:41,380 --> 00:07:49,860 +three percent طب ايش احنا بنلاحظ طلعوا بنلاحظ + +89 +00:07:49,860 --> 00:07:56,420 +احنا أنه اللي صار .. صار أن الـ equity صارت تلات + +90 +00:07:56,420 --> 00:08:02,120 +تلات فصار خسر تقريبا نص .. نص المبلغ تبعه يعني + +91 +00:08:02,120 --> 00:08:05,780 +خمسين فالمية من ثروة تبع الـ investor راحت طب خليني + +92 +00:08:05,780 --> 00:08:09,960 +أنا آخد أسوأ الظروف نضلنا ماشيين نشوف إيش .. إيش + +93 +00:08:09,960 --> 00:08:12,980 +اللي بيصير مع الـ .. مع الـ broker if the broker is + +94 +00:08:12,980 --> 00:08:17,460 +irrational عقلاني إذا غير .. irrational غير عقلاني + +95 +00:08:17,460 --> 00:08:19,740 +إذا كان الـ investor .. الـ broker .. أه؟ + +96 +00:08:23,520 --> 00:08:28,280 +أه أه بس أنا بدي آخد .. بدي آخد أسوأ الظروف and + +97 +00:08:28,280 --> 00:08:31,500 +considering that the investor is .. and + +98 +00:08:31,500 --> 00:08:34,460 +considering that the investor .. the .. the dealer + +99 +00:08:34,460 --> 00:08:37,200 +or the broker is irrational عشان to understand + +100 +00:08:37,200 --> 00:08:40,480 +يعني خلينا نحكي أن هو irrational وشو حيصير + +101 +00:08:40,480 --> 00:08:44,540 +بالأسهم تبعه إذا هو ما عملش maintenance اتذكروا + +102 +00:08:44,540 --> 00:08:48,660 +كلمة maintenance اه maintenance اتذكروها عشان .. + +103 +00:08:53,900 --> 00:09:00,800 +Okay طيب اللي راح الـ price نزل نفترض نزل خمسين + +104 +00:09:00,800 --> 00:09:07,940 +دولار مية بيصير five thousands هو بيصير four + +105 +00:09:07,940 --> 00:09:13,600 +thousands one thousand and twenty percent okay + +106 +00:09:13,600 --> 00:09:19,940 +let's go خلينا كمان to make things worse than this + +107 +00:09:21,060 --> 00:09:24,580 +Okay so هي 40 دولار شوفوا الـ price نزل 40 دولار + +108 +00:09:24,580 --> 00:09:29,700 +one hundred four thousands now four thousands zero + +109 +00:09:29,700 --> 00:09:35,680 +zero percent طب what is the next step؟ شو حيصير لو + +110 +00:09:35,680 --> 00:09:38,800 +ضلوا مستمر؟ الـ broker يخسر، الـ broker يخسر، الـ + +111 +00:09:38,800 --> 00:09:41,460 +broker يخسر، الـ broker يخسر، الـ broker يخسر، الـ + +112 +00:09:41,460 --> 00:09:42,220 +broker يخسر، الـ broker يخسر، الـ broker يخسر، الـ + +113 +00:09:42,220 --> 00:09:42,460 +broker يخسر، الـ broker يخسر، الـ broker يخسر، الـ + +114 +00:09:42,460 --> 00:09:42,480 +broker يخسر، الـ broker يخسر، الـ broker يخسر، الـ + +115 +00:09:42,480 --> 00:09:42,540 +broker يخسر، الـ broker يخسر، الـ broker يخسر، الـ + +116 +00:09:42,540 --> 00:09:45,060 +broker يخسر، الـ broker يخسر، الـ broker يخسر، الـ + +117 +00:09:45,060 --> 00:09:51,740 +broker يخسر، الـ broker يخسر the .. the investor + +118 +00:09:51,740 --> 00:09:58,700 +lose all of his money خسر كل فلوسه okay if the + +119 +00:09:58,700 --> 00:10:03,260 +broker continues or if the investor continues + +120 +00:10:03,260 --> 00:10:08,660 +trading on his account it means the .. the lose + +121 +00:10:08,660 --> 00:10:13,650 +will leak leak يعني تتسرب الـ leak to the broker + +122 +00:10:13,650 --> 00:10:18,090 +accounts يعني إذا ضلوا المستثمر يتاجر الخسائر + +123 +00:10:18,090 --> 00:10:23,190 +هتتسرب لـ .. للـ broker be careful we are + +124 +00:10:23,190 --> 00:10:26,570 +considering that the broker is irrational الـ + +125 +00:10:26,570 --> 00:10:37,110 +broker اسمه يعني إرشمال يعني مش عقلانية and + +126 +00:10:37,110 --> 00:10:38,710 +the number of shares is 100 + +127 +00:10:45,850 --> 00:10:52,650 +of one thousand minus but this is minus one + +128 +00:10:52,650 --> 00:10:58,870 +thousand is the value of the brokerage, which is if + +129 +00:10:58,870 --> 00:11:01,150 +you subtract four thousand minus one thousand, the + +130 +00:11:01,150 --> 00:11:05,310 +brokerage now will decrease, so the broker loses a + +131 +00:11:05,310 --> 00:11:09,690 +thousand. One thousand. Okay, now the... the margin + +132 +00:11:09,690 --> 00:11:12,050 +is... is + +133 +00:11:14,630 --> 00:11:21,450 +33% في كل مادة مادة مادة مادة مادة مادة مادة مادة + +134 +00:11:21,450 --> 00:11:39,490 +مادة مادة مادة مادة مادة مادة + +135 +00:11:57,240 --> 00:12:04,220 +So now this is the case, this is why in the + +136 +00:12:04,220 --> 00:12:08,280 +financial markets they ask the broker to book + +137 +00:12:08,280 --> 00:12:09,600 +later. + +138 +00:12:38,120 --> 00:12:44,000 +عندنا خمسين فمية مواطن قصارى ثلاثة و اتنين، معناه + +139 +00:12:44,000 --> 00:12:49,540 +أن الفيسبوك سيحصل تقريبا خمسين فمية من طوا ثلاثة و + +140 +00:12:49,540 --> 00:12:54,680 +اتنين، بعدين سيحصل تقريبا تقريبا ثلاثة و أتنين زي + +141 +00:12:54,680 --> 00:13:00,320 +التوقف، مع أن في مرحلة المرحلة سيأتي التوقف + +142 +00:13:03,300 --> 00:13:10,580 +كيف خسر 50%؟ كيف خسر 50%؟ من خمسين لتلاتة وقريب من + +143 +00:13:10,580 --> 00:13:11,280 +خمسين تلاتة وقريب من خمسين تلاتة وقريب من خمسين + +144 +00:13:11,280 --> 00:13:13,180 +تلاتة وقريب من خمسين تلاتة وقريب من خمسين تلاتة + +145 +00:13:13,180 --> 00:13:15,240 +وقريب من خمسين تلاتة وقريب من خمسين تلاتة وقريب من + +146 +00:13:15,240 --> 00:13:16,520 +خمسين تلاتة وقريب من خمسين تلاتة وقريب من خمسين + +147 +00:13:16,520 --> 00:13:19,320 +تلاتة وقريب من خمسين تلاتة وقريب من خمسين تلاتة + +148 +00:13:19,320 --> 00:13:21,980 +وقريب من خمسين تلاتة وقريب من خمسين تلاتة وقريب من + +149 +00:13:21,980 --> 00:13:29,100 +خمسين تلاتة وقري + +150 +00:13:42,420 --> 00:13:48,240 +الفلوس يمشي حسب السبب كمان لفلوسه لفوق. So at a + +151 +00:13:48,240 --> 00:13:51,160 +particular time, at a particular price + +152 +00:14:10,630 --> 00:14:13,410 +what it means بيه أنت ناس معجن هارد و أربع يزيد + +153 +00:14:13,410 --> 00:14:16,430 +الفلوس يعني to add cash هيضيف cash يزيد الفلوس + +154 +00:14:16,430 --> 00:14:19,410 +تجيب الفلوس و هتضيف عارف ما اختلعت و to protect + +155 +00:14:19,410 --> 00:14:24,330 +his account otherwise... otherwise يعني إذا أنا + +156 +00:14:24,330 --> 00:14:27,290 +صوّعش ال investors if the investors didn't listen + +157 +00:14:27,290 --> 00:14:32,990 +to the brokers, in this case the broker has a right + +158 +00:14:32,990 --> 00:14:40,130 +to close his account or to sell off his position. + +159 +00:14:44,420 --> 00:14:48,820 +هذا اللي أنا بحكيه فيها يبسطه من الانتصار، يعني + +160 +00:14:48,820 --> 00:14:56,920 +لإيجاد الصيانة لازم يكون يعني معروف، كيف نحصل؟ + +161 +00:14:56,920 --> 00:15:02,000 +خلينا احنا طريقة حسب الماضي و نتور منها في نفس + +162 +00:15:02,000 --> 00:15:02,720 +طريقة الحسب الماضي. + +163 +00:15:07,430 --> 00:15:10,410 +طبعا كم ساعة؟ طبعا كم ساعة؟ طبعا كم ساعة؟ طبعا كم + +164 +00:15:10,410 --> 00:15:35,010 +ساعة؟ طبعا كم ساعة؟ طبعا كم ساعة؟ طبعا كم ساعة؟ + +165 +00:15:40,950 --> 00:15:44,950 +عشان نحسب ال margin هذا اللي احنا صممناه سابقا + +166 +00:15:44,950 --> 00:15:50,770 +فصدر 4 كده كل مرة طيب اللي اشد اللي احنا صارفه ان + +167 +00:15:50,770 --> 00:15:58,230 +في 100P 100 اللي هي أمرا و شاز دي مش معروف مارفس + +168 +00:15:58,230 --> 00:16:04,610 +اللي بقول انه 4 كده صح؟ اللي احنا اتطلبناه اغير لأ + +169 +00:16:04,610 --> 00:16:08,310 +لأ تفسير + +170 +00:16:08,940 --> 00:16:17,840 +اللي هو D بمية و B is the maintenance margin طب + +171 +00:16:17,840 --> 00:16:22,100 +الحالة هاللي تانية ميش مارجن او support ال + +172 +00:16:22,100 --> 00:16:26,200 +maintenance margin تصلق + +173 +00:16:26,200 --> 00:16:29,500 +هذا البرنامج اذا انا قطعتكم ال maintenance margin + +174 +00:16:29,500 --> 00:16:33,680 +كام يعني اجيال حكاية ال maintenance margin بساوي + +175 +00:16:33,680 --> 00:16:39,920 +قرر ان ال maintenance margin يساوي 30%يعني ال + +176 +00:16:39,920 --> 00:16:43,600 +maintenance margin تلاتين في المية يعني عن تلاتين + +177 +00:16:43,600 --> 00:16:46,840 +في المية طبعا هو هان خمسين اربعين عن تلاتين في + +178 +00:16:46,840 --> 00:16:51,460 +المية هان هيوقف ايش ال investment تبعه طبعا عنده + +179 +00:16:51,460 --> 00:16:55,260 +two option يا اما بجيب فلوس يا اما بسكله الحساب + +180 +00:16:55,260 --> 00:16:58,520 +هذا معناه ال maintenance margin طبعا انا بتبقى + +181 +00:16:58,520 --> 00:17:04,050 +عارف ال price كل اشي انا معروف عنده هانبس معادل ال + +182 +00:17:04,050 --> 00:17:07,110 +price مش معروف فإذا أنا عرفت ال price و كام لازم + +183 +00:17:07,110 --> 00:17:14,070 +واقفه فبتنحل المشكلة فهنا 30% انتبهوا معانا طبعا + +184 +00:17:14,070 --> 00:17:20,850 +طبعا هذه رياضية بسيطة بتصير خليكم + +185 +00:17:20,850 --> 00:17:28,910 +معانا فضرب تبادل يطلع 100 100P في .. okay يطلع + +186 +00:17:28,910 --> 00:17:29,390 +كام؟ + +187 +00:17:36,630 --> 00:17:41,630 +نقص من 4000 طبعا متأكدين ان ال maintenance margin + +188 +00:17:41,630 --> 00:17:50,290 +30% ال 30% ممن جبناها موجودة + +189 +00:17:50,290 --> 00:17:57,970 +في السؤال okay 30% طبعا بنحل احنا الموضوع ال 100B + +190 +00:17:57,970 --> 00:18:08,940 +من 30B بطلع 100B من .. عندنا ال .. كيف؟النية بي .. + +191 +00:18:08,940 --> 00:18:14,620 +لأ من .. طبعا هذه تلات .. تلاتين بي بتصير سبعين بي + +192 +00:18:14,620 --> 00:18:22,680 +okay بتساوي الأربع تلاف، مظبوط؟ وبعد هيك بتساوي + +193 +00:18:22,680 --> 00:18:30,460 +أربع تلاف تقسيم سبعين okay + +194 +00:18:34,580 --> 00:18:40,820 +طيب خلينا نشوف إيش الجواب تبعتهم 57 طيب بتلع + +195 +00:18:40,820 --> 00:18:46,660 +الجواب 57 اتطلعوا نرجع على ال .. نرجع على الحساب + +196 +00:18:46,660 --> 00:18:56,020 +تبعنا اتطلعوا على ال table طبعا السعر 70.50 بناتهم + +197 +00:18:56,020 --> 00:19:00,520 +هيكون هنا إيش يعملوا إيقاف لما يصل السعر على 57 + +198 +00:19:03,720 --> 00:19:09,060 +هيعمله stop investment او يحكيله please add more + +199 +00:19:09,060 --> 00:19:15,760 +cash او اضف لنا cash طبعا + +200 +00:19:15,760 --> 00:19:28,020 +هذا هو ال maintenance margin طب انا اسألوني + +201 +00:19:28,020 --> 00:19:31,860 +إذا في حد عنده سؤال لأ لسه في احنا هنطور شوية في + +202 +00:19:31,860 --> 00:19:32,200 +السؤال + +203 +00:19:36,020 --> 00:19:54,960 +57% 57% 57% 57% 57% 57% 57% 57% 57% 57% 57 + +204 +00:19:54,960 --> 00:20:04,260 +% + +205 +00:20:05,950 --> 00:20:15,290 +Okay فزي ما أنتو شايفين هان سبعة + +206 +00:20:15,290 --> 00:20:18,170 +و خمسين دولار فشوفتوا أنتو هان سبعة و خمسين دولار + +207 +00:20:18,170 --> 00:20:25,850 +اجت من ال ..ماشي + +208 +00:20:25,850 --> 00:20:28,290 +نعمل شوية تطوير على السؤال + +209 +00:20:34,080 --> 00:20:38,660 +بن .. السؤال بيحكي انه what is the price تبقى ل .. + +210 +00:20:38,660 --> 00:20:41,340 +this is a good question what... what is the price + +211 +00:20:41,340 --> 00:20:47,680 +that the... the dealer ask for maintenance ask for + +212 +00:20:47,680 --> 00:20:51,540 +maintenance for maintenance بتذكر ب chapter one + +213 +00:20:51,540 --> 00:20:55,520 +كنا نحكي بال broker call فاكرينه؟ اذا بترجعوا هذا + +214 +00:20:55,520 --> 00:21:00,500 +هو نفسه ال broker callفلما يصل عند .. طبعا هو مش + +215 +00:21:00,500 --> 00:21:04,680 +هيسأل .. مش هينتظر لما يصل سبعة و خمسين دولار، عند + +216 +00:21:04,680 --> 00:21:07,860 +ما يصل تمانية و خمسين، تسعة و خمسين فهو preparing + +217 +00:21:07,860 --> 00:21:13,760 +himself to call the investorهيحضر نفسه يتصل بال + +218 +00:21:13,760 --> 00:21:16,620 +investor be careful هيتصل فيه على ال mobile احكيله + +219 +00:21:16,620 --> 00:21:22,460 +okay be careful the price is now is 58 so if it + +220 +00:21:22,460 --> 00:21:28,560 +goes down 57 you may receive a margin call ايش a + +221 +00:21:28,560 --> 00:21:34,000 +margin call يعني حضر حالك اذا السعر الآن السعر 58 + +222 +00:21:34,000 --> 00:21:38,280 +إذا السعر وصل ل 57 و اقل احنا هنتصل فيك and + +223 +00:21:38,280 --> 00:21:43,120 +prepare your cash حضر ال cash تبعتكthis is what + +224 +00:21:43,120 --> 00:21:49,500 +the dealer is doing when the price close to the + +225 +00:21:49,500 --> 00:21:54,040 +fifty seven هذا الكلان هيسوي ال dealer لما السعار + +226 +00:21:54,040 --> 00:21:57,740 +تقترب لل fifty seven فهو مش هو not waiting until + +227 +00:21:57,740 --> 00:22:00,780 +the price is hit you know what means hit, hit يعني + +228 +00:22:00,780 --> 00:22:05,760 +تضرب بال fifty sevenjust one tick لما بحكي tick + +229 +00:22:05,760 --> 00:22:10,760 +يعني one tick before the fifty seven he may call + +230 +00:22:10,760 --> 00:22:16,840 +the investor one tick يعني مش بيسموها تك واحدة ال + +231 +00:22:16,840 --> 00:22:22,420 +prices لما بتعمل jump بتعمل jump by tick كل tick + +232 +00:22:22,420 --> 00:22:28,470 +مثلا دولار واحدSo one tick before the price يعني + +233 +00:22:28,470 --> 00:22:33,290 +tick واحدة مش احنا مرات بنقول بال tick اه ال tick + +234 +00:22:33,290 --> 00:22:37,470 +هذه معناها اللي هو قفزة واحدة للسعر يعني مثلا من + +235 +00:22:37,470 --> 00:22:41,070 +سبعة و خمسين تمانية و خمسين this is one tick So if + +236 +00:22:41,070 --> 00:22:45,810 +the price close one tick to the fifty seven the + +237 +00:22:45,810 --> 00:22:49,830 +investor may receive a margin call to prepare his + +238 +00:22:49,830 --> 00:22:51,490 +or her cash okay + +239 +00:22:55,800 --> 00:23:00,360 +نجرب 40% شو هيصير ال price according to فاطمة if + +240 +00:23:00,360 --> 00:23:05,760 +the... if the... if the maintenance margin is 40% + +241 +00:23:05,760 --> 00:23:11,220 +تطلع يا هان وين تتوقع السعر هيصير؟ يعني أنت بتحكي + +242 +00:23:11,220 --> 00:23:17,060 +هان 40% صح؟ هتكون قريبة لل 70 خلينا لو نجرب بلاش + +243 +00:23:17,060 --> 00:23:22,060 +... نجرب 45% ال 45% هيقلع السعر من هنا نجربوا على + +244 +00:23:22,060 --> 00:23:29,100 +40% تعالوا تشوفوانجرب على اربعين في المية okay دوق + +245 +00:23:29,100 --> 00:23:33,100 +... دوق jump to the conclusion خلينا نشوف 40 + +246 +00:23:33,100 --> 00:23:39,560 +percent طبعا بالحالة هيحصير اربعين P is equal one + +247 +00:23:39,560 --> 00:23:44,860 +hundred P minus forty thousands وبتساوي sixty P + +248 +00:23:44,860 --> 00:23:49,520 +four thousands وبالتالي P هتساوي four thousand + +249 +00:23:49,520 --> 00:23:56,160 +divided by sixty بطلع ستة و ستين point فهيكون السعر + +250 +00:23:56,160 --> 00:24:05,720 +في المنطقة هذه okay that's it طيب احنا so far we + +251 +00:24:05,720 --> 00:24:09,080 +ignore the importance of the interest rate مظبوط + +252 +00:24:09,080 --> 00:24:13,720 +ولا لا نتجاهل the rule of the interest rate now + +253 +00:24:13,720 --> 00:24:16,840 +in this example we will consider the importance of + +254 +00:24:16,840 --> 00:24:21,050 +interest rate هناخد بعين الاعتبار دور ال interest + +255 +00:24:21,050 --> 00:24:24,790 +rate عشان نحسب ال calculation of rate of return + +256 +00:24:24,790 --> 00:24:31,570 +اطلعوا على المثال موجود في page 79 لو هذا ال + +257 +00:24:31,570 --> 00:24:37,070 +investor معايا؟ + +258 +00:24:37,070 --> 00:24:42,470 +okay لو هذا ال investor he + +259 +00:24:42,470 --> 00:24:49,370 +borrowed 10,000$ لو اتدين 10,000$ from the investor + +260 +00:24:49,370 --> 00:24:55,650 +from the broker and the rest is covered by himself + +261 +00:24:55,650 --> 00:25:03,550 +والباقي غطى بنفسه يعني + +262 +00:25:03,550 --> 00:25:08,450 +أربعة آلاف دولار يعني بالمثال الأول ال buy and come + +263 +00:25:08,450 --> 00:25:11,750 +four thousand but in this example he bought ten + +264 +00:25:11,750 --> 00:25:15,110 +thousands and the rest is covered by himself + +265 +00:25:16,070 --> 00:25:21,390 +والباقي غطى بنفسه يعني بيكون هنا ال fifty percent + +266 +00:25:21,390 --> 00:25:25,570 +مظبوط بيكون ال margin هنا fifty percent لأنه عشرة + +267 +00:25:25,570 --> 00:25:28,850 +تلاف منه وعشرة تلاف من ال broker طيب بدنا ناخد + +268 +00:25:28,850 --> 00:25:32,550 +three scenarios بدنا ناخد ايش three scenarios + +269 +00:25:32,550 --> 00:25:36,850 +three scenarios يعني three options او three + +270 +00:25:36,850 --> 00:25:40,720 +probabilities بدنا نشوف السعر اذا طلع السعر + +271 +00:25:40,720 --> 00:25:44,520 +ماتغيرش if the prices go down so we have three + +272 +00:25:44,520 --> 00:25:48,380 +scenarios if the prices go up if unchanged if the + +273 +00:25:48,380 --> 00:25:52,800 +prices go down so and see to observe the changes + +274 +00:25:52,800 --> 00:25:58,340 +خليني أشوف ال changes بال .. طيب a change in the + +275 +00:25:58,340 --> 00:26:02,260 +price 30 + +276 +00:26:02,260 --> 00:26:13,320 +% up يعني ارتفعت no change so it is zero so if it + +277 +00:26:13,320 --> 00:26:19,960 +is zero no change and thirty percent goes down + +278 +00:26:23,280 --> 00:26:29,180 +طريقة خيارات لتشوف ايش .. كيف بتأثر ال .. ال worth + +279 +00:26:29,180 --> 00:26:32,480 +تبع ال investors or return on investments العادل + +280 +00:26:32,480 --> 00:26:36,880 +على الاستثمار في حالة ال .. الأسعار ارتفعت في حالة + +281 +00:26:36,880 --> 00:26:42,280 +الأسعار ما تغيرتش في حالة الأسعار is going down طيب + +282 +00:26:42,280 --> 00:26:48,580 +نشوف مع نهاية السنة ال end of the year مع نهاية + +283 +00:26:48,580 --> 00:26:50,400 +السنة شو بيصير في الثروة .. في ثروته + +284 +00:26:53,570 --> 00:27:01,330 +لو ربح 30% عفوا لو الأسعار ارتفعت 30% كام بيربح؟ + +285 +00:27:01,330 --> 00:27:07,730 +انتوا حاسبوا لوحدكم هو الثروة تبعته حكينا عشرة تلاف + +286 +00:27:07,730 --> 00:27:13,350 +تبعه خلوها بالهامش plus ten thousands أخدهم من ال + +287 +00:27:13,350 --> 00:27:20,020 +broker صح؟ فثروته كام صارت؟ عشرين ألف مظبوط احنا + +288 +00:27:20,020 --> 00:27:23,860 +بدأنا حكينا if he has ten thousand dollar and + +289 +00:27:23,860 --> 00:27:26,440 +borrowed ten thousand dollar from the broker so he + +290 +00:27:26,440 --> 00:27:31,120 +has twenty thousand dollar يعني هو عنده عشرين ألف + +291 +00:27:31,120 --> 00:27:34,880 +دولار العشرين ألف دولار هدول فيهم متين سهم يعني + +292 +00:27:34,880 --> 00:27:38,840 +شريين سهم فيه متساهم بالدولار هلأ خلينا نشوف + +293 +00:27:38,840 --> 00:27:42,920 +ال prices is go up thirty percent اذا الأسعار ارتفعت + +294 +00:27:42,920 --> 00:27:50,360 +thirty percent كم بيكون ربحان؟ 6000 صح بيقول ربحان + +295 +00:27:50,360 --> 00:27:56,940 +6000 so 6000 plus 20000 فهيقول عنده 26000 مع نهاية + +296 +00:27:56,940 --> 00:28:02,940 +السنة طبعا لو احنا فصلناهم 26000 عشرة تلاف for the + +297 +00:28:02,940 --> 00:28:06,840 +investor عشرة تلاف for the broker 6000 is the + +298 +00:28:06,840 --> 00:28:13,480 +profits forget ما تنسوش that he borrowed 10,000 + +299 +00:28:13,480 --> 00:28:21,450 +from the broker and 9% interest ما تنسوش أنه هو + +300 +00:28:21,450 --> 00:28:23,970 +أداين عشرة تلاف من ال broker and this is not for + +301 +00:28:23,970 --> 00:28:29,090 +free و هذا مش ببلاشة على الفائضة what is the + +302 +00:28:29,090 --> 00:28:32,690 +interest rate is nine percent و الفائضة كام تسعة + +303 +00:28:32,690 --> 00:28:38,770 +في المية okay طيب let's carry on خلينا نكمل so + +304 +00:28:38,770 --> 00:28:41,570 +far you understand what I mean here from where the + +305 +00:28:41,570 --> 00:28:44,510 +twenty six thousands coming it's coming from the + +306 +00:28:44,510 --> 00:28:47,550 +total worth twenty thousands plus the profits so + +307 +00:28:47,550 --> 00:28:50,670 +the profit twenty .. so the total amount is twenty + +308 +00:28:50,670 --> 00:28:54,130 +six thousands يعني لو احنا فصلناهم الستة و عشرين + +309 +00:28:54,130 --> 00:29:01,910 +الف هدول عشرة و عشرة و ستة على ال broker و عشرة + +310 +00:29:01,910 --> 00:29:06,660 +على ال investor و ستة ال profit this is I asked + +311 +00:29:06,660 --> 00:29:12,500 +before ما حكيتها لك ربح ارتفع السوق كام تلاتية في + +312 +00:29:12,500 --> 00:29:16,340 +المليون طب if the if if the price is there is no + +313 +00:29:16,340 --> 00:29:21,360 +changes in the price so twenty thousands if the if + +314 +00:29:21,360 --> 00:29:27,420 +the markets goes down if قداش حيخسر ستة ألف حيخسر + +315 +00:29:27,420 --> 00:29:31,580 +ستة ألف من العشرين ألف تبعته حيصير عنده أربعة عشر ألف + +316 +00:29:31,580 --> 00:29:35,120 +وأربعة عشر ألف تمام؟ + +317 +00:29:40,010 --> 00:29:48,290 +طيب يا باشا okay very simple there is no need for + +318 +00:29:48,290 --> 00:29:52,290 +humming يعني ما تتوتوش كتير احكوا directly the + +319 +00:29:52,290 --> 00:29:59,610 +questions to me which one هذي اه طيب ببساطة هلأ هو + +320 +00:29:59,610 --> 00:30:03,510 +كام عنده عشرين ألف عشرة منه و عشرة من ال broker + +321 +00:30:03,510 --> 00:30:09,670 +فصار عمره trade في السوق السوق ارتفع ل 30% فاحنا + +322 +00:30:09,670 --> 00:30:16,470 +بدنا نحكي 30% time يعني ضرب ال 20 ألف كام؟ 6 ألف + +323 +00:30:16,470 --> 00:30:20,590 +ال 6 ألف زي الفروة ال 20 ألف اللي معاهي 26 ألف + +324 +00:30:20,590 --> 00:30:24,890 +that's it طبعا هذا صفر ما صار تغير ضلت الفروة طبعا + +325 +00:30:24,890 --> 00:30:30,730 +هذا الخفضة الفروة طبعا okay هلا بدنا ناخد to + +326 +00:30:30,730 --> 00:30:33,590 +consider the interest rates خلينا نشوف + +327 +00:30:36,530 --> 00:30:41,530 +ال repayment بده يسد الفلوس لمين repayment + +328 +00:30:41,530 --> 00:30:46,890 +principal plus the interest بده يسد ال broker مصاري + +329 +00:30:46,890 --> 00:30:54,050 +الفلوس و ما هي الفائدة طيب في الحالة الأولى طبعا + +330 +00:30:54,050 --> 00:30:57,550 +هيكون طبعا كام احسبولي كام الفلوس ال broker زائد + +331 +00:30:57,550 --> 00:31:00,970 +الفائدة كام عشرة تلاف عشرة تلاف عشرة تلاف عشرة تلاف + +332 +00:31:00,970 --> 00:31:01,410 +عشرة تلاف عشرة تلاف عشرة تلاف عشرة تلاف عشرة تلاف عشر + +333 +00:31:01,410 --> 00:31:01,510 +تلاف عشرة تلاف عشرة تلاف عشرة تلاف عشرة تلاف عشر + +334 +00:31:01,510 --> 00:31:02,730 +تلاف عشرة تلاف عشرة تلاف عشرة تلاف عشرة تلاف عشر + +335 +00:31:02,730 --> 00:31:07,080 +تلاف عشرة تلاف عشرة تلاف عشر تلاف بقوا يا بنات هان + +336 +00:31:07,080 --> 00:31:13,320 +الاستثمار ده بقى عشرين ألف صح؟ of them منهم ten + +337 +00:31:13,320 --> 00:31:16,880 +thousands for the investor عشرة الألف لل investors + +338 +00:31:16,880 --> 00:31:21,300 +and ten thousands to the broker شوف هو هو broker و + +339 +00:31:21,300 --> 00:31:26,240 +أنا investor I بيه ten thousand add لما نستخدم + +340 +00:31:26,240 --> 00:31:35,280 +كلمة add add يعني عند نسبة nine percent add nine + +341 +00:31:35,280 --> 00:31:38,780 +percent يعني هو أخد عشرة تلاف دولار من ال broker + +342 +00:31:38,780 --> 00:31:42,980 +بنسبة تسعة في المية أداش هيرجع لل broker أداش + +343 +00:31:42,980 --> 00:31:47,760 +هيدفعله فلوس؟ لما بيسدوا كام هيسدوا؟ كيف حسبناها + +344 +00:31:47,760 --> 00:31:53,320 +عشرة تلاف دولار؟ في عشرة تلاف دولار ten thousand + +345 +00:31:53,320 --> 00:31:56,980 +dollar هي and ten thousand dollar the ten thousand + +346 +00:31:56,980 --> 00:32:01,720 +is the broker is bought by from the broker and + +347 +00:32:01,720 --> 00:32:06,580 +nine percent is the interest so تسعة في المية في + +348 +00:32:06,580 --> 00:32:11,960 +عشرة تلاف كم تسعمية دولار plus العشر تلاف هيسدوا كم + +349 +00:32:11,960 --> 00:32:16,480 +عشرة تلاف تسعمية في كل الحلات هيسدوا عشرة تلاف + +350 +00:32:16,480 --> 00:32:20,640 +تسعمية ولا هيختلف نفس الشيء + +351 +00:32:23,120 --> 00:32:29,200 +ما خسرش خسر الربح مش مش شغلته اه so ten thousand + +352 +00:32:29,200 --> 00:32:34,680 +nine hundred okay so you understand so far no okay + +353 +00:32:34,680 --> 00:32:39,160 +now we want to calculate the investor rate of + +354 +00:32:39,160 --> 00:32:43,900 +return investor rate of return investor + +355 +00:32:52,310 --> 00:32:58,070 +rate of return يعني عائد للمستثمر عائد على الفلوس + +356 +00:32:58,070 --> 00:33:03,910 +المستثمر طيب تستطيعوا تحسبوها لحالكم بجيت البنات + +357 +00:33:03,910 --> 00:33:08,690 +قلنا rest of students خلينا + +358 +00:33:08,690 --> 00:33:11,450 +بس أعطيكوا two minutes خدوا two minutes ت + +359 +00:33:11,450 --> 00:33:18,210 +calculate the investor A على الدفتر لأول + +360 +00:33:18,210 --> 00:33:35,380 +حالة we are to the first one then to the second إيش + +361 +00:33:35,380 --> 00:33:38,280 +القاعدة اللي هتستخدموها ساعدكم شوية بالقاعدة + +362 +00:33:38,280 --> 00:33:47,500 +استخدموا b1 minus c0 divided by b0 هذه ال return + +363 +00:33:48,810 --> 00:33:55,690 +Okay يلا نشوف مين يحسب ليها تفضليها استخدميها + +364 +00:33:55,690 --> 00:34:06,470 +أول + +365 +00:34:06,470 --> 00:34:09,990 +حاجة عندنا ستة و عشرين ألف اللي هي end of year كان + +366 +00:34:09,990 --> 00:34:14,570 +عندنا ستة و عشرين ألف بنخصر منهم بتاع ال broker + +367 +00:34:14,570 --> 00:34:24,390 +اللي هو العشرة وتسع مية عشان نطبق ال .. عشان + +368 +00:34:24,390 --> 00:34:27,950 +نطبق + +369 +00:34:27,950 --> 00:34:31,290 +ال .. عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال + +370 +00:34:31,290 --> 00:34:31,430 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +371 +00:34:31,430 --> 00:34:31,510 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +372 +00:34:31,510 --> 00:34:32,490 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +373 +00:34:32,490 --> 00:34:33,090 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +374 +00:34:33,090 --> 00:34:36,290 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +375 +00:34:36,290 --> 00:34:46,170 +عشان نطبق ال .. عشان + +376 +00:34:46,170 --> 00:34:46,690 +نطبق ال + +377 +00:34:51,280 --> 00:34:57,960 +طبعا على ال .. على ال نفس الشغلة .. طبعا + +378 +00:34:57,960 --> 00:35:06,400 +بتطلع .. بتطلع fifty one percent .. كام؟ عندنا + +379 +00:35:06,400 --> 00:35:10,340 +عشرين ألف .. هلا نشوف الثانية .. ثانية .. ثانية + +380 +00:35:10,340 --> 00:35:14,740 +.. fifty one percent يعني عندنا ال 50% أكثر من نص + +381 +00:35:14,740 --> 00:35:19,400 +ربع .. أكثر من نص تاريخي which is fineعشرين ألف + +382 +00:35:19,400 --> 00:35:26,260 +ناقص .. ناقص العشر تلاف وتسعمية تسعة تلاف ومئة + +383 +00:35:26,260 --> 00:35:28,760 +تسعة تلاف ومئة .. نعم تسعة تلاف ومئة .. نعم تسعة + +384 +00:35:28,760 --> 00:35:29,640 +تلاف ومئة .. نعم تسعة تلاف ومئة .. نعم تسعة تلاف + +385 +00:35:29,640 --> 00:35:30,200 +ومئة .. نعم تسعة تلاف ومئة .. نعم تسعة تلاف ومئة + +386 +00:35:30,200 --> 00:35:30,620 +.. نعم تسعة تلاف ومئة .. نعم تسعة تلاف ومئة .. نعم + +387 +00:35:30,620 --> 00:35:31,140 +تسعة تلاف ومئة .. نعم تسعة تلاف ومئة .. نعم تسعة + +388 +00:35:31,140 --> 00:35:34,540 +تلاف ومئة .. نعم تسعة تلاف ومئة .. نعم تسعة تلاف + +389 +00:35:34,540 --> 00:35:41,000 +ومئة .. نعم تسعة تلاف ومئة .. نعم تسعة تلاف ومئة + +390 +00:35:41,000 --> 00:35:41,320 +.. ن + +391 +00:36:04,630 --> 00:36:05,750 +مش عارف بقى مش فاهم + +392 +00:36:14,120 --> 00:36:19,020 +هو خسر حصل أربعة عشر ألف فأنا نقسم منهم العشر ألف + +393 +00:36:19,020 --> 00:36:30,100 +تسعمية ماهي + +394 +00:36:30,100 --> 00:36:38,140 +الـ V1 شفرتين اللي هي تلت ألف تسعمية ناقص العشر ألف + +395 +00:36:38,140 --> 00:36:40,460 +على العشر ألف + +396 +00:36:48,110 --> 00:36:55,970 +69% yes and he or she lost 69 percent of his + +397 +00:36:55,970 --> 00:37:04,450 +wealth well thank you very much yeah so the if you + +398 +00:37:04,450 --> 00:37:08,030 +calculate the interest or the rate of return + +399 +00:37:12,120 --> 00:37:17,420 +شكرا جزيلا لك مرة أخرى لإجابة هذا الفيديو و إذا + +400 +00:37:17,420 --> 00:37:32,780 +فقط قمت بإدخال الـ 51% هنا و 9% و 69% فهذه + +401 +00:37:32,780 --> 00:37:40,920 +هي التخطيطات لرسالة عودة بعد الاستثمار في محافظة + +402 +00:37:40,920 --> 00:37:49,100 +المجموعات حسنًا قبل أن تغادر تحاول تقرير اتجارات + +403 +00:37:49,100 --> 00:37:54,640 +الشراء التي هي الـ short sell كما أشرحت في ثلاث + +404 +00:37:54,640 --> 00:38:01,020 +مقابلات قبلها أشرح لك عندما يبدأ المستخدم بـ sell + +405 +00:38:01,020 --> 00:38:08,680 +فهنا المستخدم يبدأ بـ buy هو يدخل السوق أو يتعامل + +406 +00:38:08,680 --> 00:38:16,140 +في السوق بشركات الشراء in the other cases if the + +407 +00:38:16,140 --> 00:38:20,240 +investor engage in the market by selling أنا + +408 +00:38:20,240 --> 00:38:25,120 +وضحت لكم إياها هذا الكلام صح؟ and we call this إيه + +409 +00:38:25,120 --> 00:38:31,140 +سمينا الكلام هذا؟ لأ إذا كان الـ investor يدخل + +410 +00:38:31,140 --> 00:38:35,800 +بائع، بيكونش معاه فلوس، هو بيبيع، بيبدأ في بيع is + +411 +00:38:35,800 --> 00:38:39,120 +not .. he is starting by selling he borrow the + +412 +00:38:39,120 --> 00:38:44,750 +stock from the broker what we call this process إيش + +413 +00:38:44,750 --> 00:38:49,610 +بتسميها هذا الـ process short sell short sell so + +414 +00:38:49,610 --> 00:38:51,610 +our next meeting we will talk about the short sell diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/p_HS3Q1jsnI_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/p_HS3Q1jsnI_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..59c6a0263e21678833d8267539aabc5eeff5fe59 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/p_HS3Q1jsnI_raw.srt @@ -0,0 +1,1668 @@ +1 +00:00:21,630 --> 00:00:26,970 +بسم الله الرحمن الرحيم المرة الفاتتة احنا كنا نحكي + +2 +00:00:26,970 --> 00:00:32,870 +عن ال margin الشغل بالهامش انا هعيد الموضوع مع + +3 +00:00:32,870 --> 00:00:37,130 +إعطاء mathematical example + +4 +00:00:37,130 --> 00:00:43,790 +مع إعطاء أمثلة بحب أذكر أنه نهاية الشهر هو بيخلص + +5 +00:00:43,790 --> 00:00:48,080 +ال ..الفترة ال feedback لل assignments بتاعتكم فإن + +6 +00:00:48,080 --> 00:00:53,540 +انتوا حاولوا تخلص ال feedback تبعية ال assignment + +7 +00:00:53,540 --> 00:01:00,340 +اذا في يعني طالبات يعني مثلا انضغطوا انا ممكن يعني + +8 +00:01:00,340 --> 00:01:05,800 +اعطي فرصة كمان اسبوع ممكن اعطي فرصة خليني بس اكمل + +9 +00:01:05,800 --> 00:01:09,740 +احكي انا ه .. هعطي فرصة لمدة اسبوع بعد ال .. بعد + +10 +00:01:09,740 --> 00:01:12,700 +الامتحانات بعد انتهاء الامتحانات بعد هيك مش ه .. + +11 +00:01:13,570 --> 00:01:16,470 +ماشي بعطيكوا اسموع بعد الامتحانات بعد اسموع واحد + +12 +00:01:16,470 --> 00:01:22,610 +بعد انتهاء الامتحانات okay okay لكن ماتعملوش delay + +13 +00:01:22,610 --> 00:01:30,010 +حتى نهاية الفصل okay نرجع و نحكي بال .. بال margin + +14 +00:01:30,010 --> 00:01:35,670 +اذا انتوا كنتوا تابعوا معايا في صفحة 76 في الكتاب + +15 +00:01:35,670 --> 00:01:41,270 +76 77 ناخد مثال احنا + +16 +00:01:41,270 --> 00:01:42,390 +حكينا ال .. ال margin + +17 +00:01:45,990 --> 00:01:51,430 +intermal معناه حكينا احنا ال .. ال margin ان ال .. + +18 +00:01:51,430 --> 00:01:56,130 +ال investors open account of the .. the broker and + +19 +00:01:56,130 --> 00:01:59,610 +a portion of his account is funded by the investor + +20 +00:01:59,610 --> 00:02:03,090 +and the rest is funded by the broker يعني جزء من + +21 +00:02:03,090 --> 00:02:08,230 +الاستثمار بتم تغطيته من المستثمر و الجزء المتبقي + +22 +00:02:08,230 --> 00:02:14,590 +بتم تغطيته من ال .. ال dealer فنسبة مساهمة ال + +23 +00:02:14,590 --> 00:02:20,680 +investorلل total wealth لقيمة الثروة هو بيعتبر ال + +24 +00:02:20,680 --> 00:02:24,600 +margin يعني لو احنا أخدنا مثال مثال بسيط زي ما هو + +25 +00:02:24,600 --> 00:02:28,880 +موجود عندكم بالكتاب لو + +26 +00:02:28,880 --> 00:02:32,280 +حكينا مثلا ال assets ال assets معناها قيمة + +27 +00:02:32,280 --> 00:02:37,960 +الاستثمار we started by ten thousandsال $10,000 + +28 +00:02:37,960 --> 00:02:42,620 +دولار اللى هو زى ما كان مرفعته مائة دولار ال price + +29 +00:02:42,620 --> 00:02:48,600 +of the stock times one hundred dollar the number + +30 +00:02:48,600 --> 00:02:55,640 +of shares يعني المستثمر اشترى مائة سهم اشترى + +31 +00:02:55,640 --> 00:03:01,940 +مائة سهم خليني اوضحهم عندنا ال price one hundred + +32 +00:03:02,940 --> 00:03:07,940 +number of shares is one hundred so the asset is + +33 +00:03:07,940 --> 00:03:16,680 +this times this one hundred ten + +34 +00:03:16,680 --> 00:03:17,240 +thousands + +35 +00:03:23,410 --> 00:03:29,130 +هذا مستثمر راح يشتري أسهم okay انتبه باسمعنا عن + +36 +00:03:29,130 --> 00:03:33,810 +المثال مستثمر راح اشترق مية سهم number of shares + +37 +00:03:33,810 --> 00:03:37,330 +one hundred shares the price at one hundred dollar + +38 +00:03:37,330 --> 00:03:41,530 +so the asset is ten thousands لأنه ضربنا المية + +39 +00:03:41,530 --> 00:03:46,910 +دولار في المية سهم قيمة الاستثمار فضروري تكون + +40 +00:03:46,910 --> 00:03:51,220 +معاكم لقلاقة الحاسوب عشان تتبعوا معاياطيب هلا اللي + +41 +00:03:51,220 --> 00:03:56,540 +صار حكينا أنه the investors open a margin account + +42 +00:03:56,540 --> 00:04:02,700 +okay of the ten thousand he borrowed four + +43 +00:04:02,700 --> 00:04:06,700 +thousands okay + +44 +00:04:06,700 --> 00:04:16,300 +he borrows by loans و اقترد four thousands and the + +45 +00:04:16,300 --> 00:04:20,280 +rest is paid by himselfوالباقي كم؟ six thousands + +46 +00:04:20,280 --> 00:04:26,040 +equity is paid by them by him so the margin now + +47 +00:04:26,040 --> 00:04:32,180 +the margin as we explain the margin is the + +48 +00:04:32,180 --> 00:04:38,140 +percentage of the contribution of the investors to + +49 +00:04:38,140 --> 00:04:41,930 +the total wealth or to the total assetsيعني + +50 +00:04:41,930 --> 00:04:45,810 +بالعربي أنه هي قيمة ال contribution اللي هو + +51 +00:04:45,810 --> 00:04:49,370 +المساهمة بتاعة ال investor على قيمة الاستثمار الكل + +52 +00:04:49,370 --> 00:04:56,230 +هاي بيسميها إيش ال margin ال margin واضح حكيناها + +53 +00:04:56,230 --> 00:05:00,010 +المرة ثلاثة فبسير + +54 +00:05:00,010 --> 00:05:04,090 +ال margin اللي هي كام مساهمة ال investors ست آلاف + +55 +00:05:04,090 --> 00:05:08,290 +ست آلاف so six thousands divided by ten thousands + +56 +00:05:10,360 --> 00:05:20,060 +so it is sixty percent is it right okay لحد + +57 +00:05:20,060 --> 00:05:25,020 +اللحظة تكون فاهم يعني so + +58 +00:05:25,020 --> 00:05:28,720 +the sixty percent خلينا نفترض أنه the prices is + +59 +00:05:28,720 --> 00:05:33,420 +going down احنا بنحاول أنه ناخد the worst case أنه + +60 +00:05:33,420 --> 00:05:38,630 +أسوأ الظروف when the prices go downthe margin is + +61 +00:05:38,630 --> 00:05:41,850 +also go down كمان ال margin بنزل خلينا نشوف ال + +62 +00:05:41,850 --> 00:05:44,810 +price one hundred خلينا نخليها تسمينين eighty + +63 +00:05:44,810 --> 00:05:48,250 +hundred .. eighty dollar the price was one hundred + +64 +00:05:48,250 --> 00:05:50,810 +and now is eighty dollar so the price is going + +65 +00:05:50,810 --> 00:05:55,090 +down the number of shares so the assets how much + +66 +00:05:56,420 --> 00:06:00,700 +أنت دايش ال assets eight thousands right of them + +67 +00:06:00,700 --> 00:06:04,160 +four thousands لون القروي ال violate لإنه احنا + +68 +00:06:04,160 --> 00:06:08,120 +مااخد قرض من ال .. and the rest is four thousands + +69 +00:06:08,120 --> 00:06:17,840 +so what is the margin now احنا + +70 +00:06:17,840 --> 00:06:20,560 +المرة الفاترة احنا حاكينا الكلام هذا بس يعني I'm + +71 +00:06:20,560 --> 00:06:26,330 +just repeating this احنا ال price تمانين دولاروعدد + +72 +00:06:26,330 --> 00:06:29,030 +الأسهم يشتراهم 100 دولار مابتغيروش مين اللي بتغير + +73 +00:06:29,030 --> 00:06:34,670 +بس ال price يا ال price يا بنزل يا بطلع ماعليش أيث + +74 +00:06:34,670 --> 00:06:37,830 +.. هيأثر .. هيأثر على ال assets و هيأثر على ال + +75 +00:06:37,830 --> 00:06:41,830 +equity و هيأثر على ال margin طبعا ارجع لتعريف + +76 +00:06:41,830 --> 00:06:44,410 +المحاضرة الفاترة ال margin هو نسبة مساهمة ال + +77 +00:06:44,410 --> 00:06:48,950 +investor على ال total wealth طيب هلأ قداش ال + +78 +00:06:48,950 --> 00:06:54,110 +margin ال margin fifty percentمن وين جيبناها + +79 +00:06:54,110 --> 00:06:59,230 +البنات اللي .. اللي هي ال 4000 بتاعة ال loan ال + +80 +00:06:59,230 --> 00:07:02,470 +4000 بتاعة ال equity على ال 8000 بتاعة ال assets + +81 +00:07:02,470 --> 00:07:09,450 +نروح كمان السعر النزل و أكتر من هيك 70$ شو أنتوا + +82 +00:07:09,450 --> 00:07:14,110 +بتلاحظوا بال .. بال equity ان واحد الزنا بيخسر + +83 +00:07:14,110 --> 00:07:20,690 +أداش خسر من .. من لما نزل .. 2000$ خسر طب هلأ أروح + +84 +00:07:20,690 --> 00:07:25,620 +كمانقداش حيصير هون seven thousands and here three + +85 +00:07:25,620 --> 00:07:31,740 +thousands and here is four thousands and now اه + +86 +00:07:31,740 --> 00:07:37,160 +sorry yes so here four thousands and three + +87 +00:07:37,160 --> 00:07:41,380 +thousands forty + +88 +00:07:41,380 --> 00:07:49,860 +three percent طب ايش احنا بنلاحظ طلعوا بنلاحظ + +89 +00:07:49,860 --> 00:07:56,420 +احناإنه اللي صار .. صار إن ال equity صارت تلات + +90 +00:07:56,420 --> 00:08:02,120 +تلات فصار خسر تقريبا نص .. نص المبلغ تبعه يعني + +91 +00:08:02,120 --> 00:08:05,780 +خمسية فالمية من ثروة تبع ال investor راحت طب خليني + +92 +00:08:05,780 --> 00:08:09,960 +أنا أخد الأسوأ الظروف نضلنا ماشيين نشوف إيش .. إيش + +93 +00:08:09,960 --> 00:08:12,980 +اللي بيصير مع ال .. مع ال broker if the broker is + +94 +00:08:12,980 --> 00:08:17,460 +irrational عقلاني إذا غير .. irrational غير عقلاني + +95 +00:08:17,460 --> 00:08:19,740 +إذا كان ال investor .. ال broker .. أه؟ + +96 +00:08:23,520 --> 00:08:28,280 +أه أه بس أنا بدي أخد .. بدي أخد أسوأ الظروف and + +97 +00:08:28,280 --> 00:08:31,500 +considering that the investor is .. and + +98 +00:08:31,500 --> 00:08:34,460 +considering that the investor .. the .. the dealer + +99 +00:08:34,460 --> 00:08:37,200 +or the broker is irrational عشان to understand + +100 +00:08:37,200 --> 00:08:40,480 +يعني خلينا نحكي أن هو irrational و شو هيصير + +101 +00:08:40,480 --> 00:08:44,540 +بالاسمار تبعه إذا هو ماعملش maintenance اتذكروا + +102 +00:08:44,540 --> 00:08:48,660 +كلمة maintenance اه maintenance اتذكروها عشان .. + +103 +00:08:53,900 --> 00:09:00,800 +Okay طيب اللي راح ال price نزل نفترض نزل خمسين + +104 +00:09:00,800 --> 00:09:07,940 +دولار مية بيصير five thousands هو بيصير four + +105 +00:09:07,940 --> 00:09:13,600 +thousands one thousand and twenty percent okay + +106 +00:09:13,600 --> 00:09:19,940 +let's go خلينا كمان to make things worse than this + +107 +00:09:21,060 --> 00:09:24,580 +Okay so هي 40 دولار شوفوا ال price نزل 40 دولار + +108 +00:09:24,580 --> 00:09:29,700 +one hundred four thousands now four thousands zero + +109 +00:09:29,700 --> 00:09:35,680 +zero percent طب what is the next step؟ شو هيصير لو + +110 +00:09:35,680 --> 00:09:38,800 +ضلوا مستمر؟ ال broker يخسر، ال broker يخسر، ال + +111 +00:09:38,800 --> 00:09:41,460 +broker يخسر، ال broker يخسر، ال broker يخسر، ال + +112 +00:09:41,460 --> 00:09:41,460 +broker يخسر، ال broker يخسر، ال broker يخسر، ال + +113 +00:09:41,460 --> 00:09:42,220 +broker يخسر، ال broker يخسر، ال broker يخسر، ال + +114 +00:09:42,220 --> 00:09:42,460 +broker يخسر، ال broker يخسر، ال broker يخسر، ال + +115 +00:09:42,460 --> 00:09:42,480 +broker يخسر، ال broker يخسر، ال broker يخسر، ال + +116 +00:09:42,480 --> 00:09:42,540 +broker يخسر، ال broker يخسر، ال broker يخسر، ال + +117 +00:09:42,540 --> 00:09:45,060 +broker يخسر، ال broker يخسر، ال broker يخسر، ال + +118 +00:09:45,060 --> 00:09:51,740 +broker يخسر، ال broker يخسرthe .. the investor + +119 +00:09:51,740 --> 00:09:58,700 +lose all of his money خسر كل فلوسه okay if the + +120 +00:09:58,700 --> 00:10:03,260 +broker continues or if the investor continues + +121 +00:10:03,260 --> 00:10:08,660 +trading on his account it means the .. the lose + +122 +00:10:08,660 --> 00:10:13,650 +will leak leak يعني تتسربو ال leak to the broker + +123 +00:10:13,650 --> 00:10:18,090 +accounts يعني إذا ضالوا المستثمر يتاجر الخسائر + +124 +00:10:18,090 --> 00:10:23,190 +هتتسرب ل .. لل broker be careful we are + +125 +00:10:23,190 --> 00:10:26,570 +considering that the broker is irrational ال + +126 +00:10:26,570 --> 00:10:37,110 +broker إسمه يعني إرشمال يعني مش عقلية and + +127 +00:10:37,110 --> 00:10:38,710 +the number of shares in 100 + +128 +00:10:45,850 --> 00:10:52,650 +of one thousand minus but this one minus one + +129 +00:10:52,650 --> 00:10:58,870 +thousand is the value of the brokerage which is if + +130 +00:10:58,870 --> 00:11:01,150 +you subtract four thousand minus one thousand the + +131 +00:11:01,150 --> 00:11:05,310 +brokerage now will decrease so the broker loses a + +132 +00:11:05,310 --> 00:11:09,690 +thousand one thousand okay now the .. the margin + +133 +00:11:09,690 --> 00:11:12,050 +is .. is + +134 +00:11:14,630 --> 00:11:21,450 +33% في كل مادة مادة مادة مادة مادة مادة مادة مادة + +135 +00:11:21,450 --> 00:11:39,490 +مادة مادة مادة مادة مادة مادة + +136 +00:11:57,240 --> 00:12:04,220 +So now this is the case, this is why in the + +137 +00:12:04,220 --> 00:12:08,280 +financial markets they ask the broker to book + +138 +00:12:08,280 --> 00:12:09,600 +later + +139 +00:12:38,120 --> 00:12:44,000 +عندنا خمسين فمية مواطن قصارى ثلاثة و اتنين، معناه + +140 +00:12:44,000 --> 00:12:49,540 +ان الفيسبوك سيحصل تقريبا خمسين فمية من طوا ثلاثة و + +141 +00:12:49,540 --> 00:12:54,680 +اتنين، بعدين سيحصل تقريبا تقريبا ثلاثة و أتنين زي + +142 +00:12:54,680 --> 00:13:00,320 +التوقف، مع ان في مرحلة المرحلة سيأتي التوقف + +143 +00:13:03,300 --> 00:13:10,580 +كيف خسر 50%؟ كيف خسر 50%؟ من خمسين لتلاتة وقريب من + +144 +00:13:10,580 --> 00:13:11,280 +خمسين تلاتة وقريب من خمسين تلاتة وقريب من خمسين + +145 +00:13:11,280 --> 00:13:13,180 +تلاتة وقريب من خمسين تلاتة وقريب من خمسين تلاتة + +146 +00:13:13,180 --> 00:13:15,240 +وقريب من خمسين تلاتة وقريب من خمسين تلاتة وقريب من + +147 +00:13:15,240 --> 00:13:16,520 +خمسين تلاتة وقريب من خمسين تلاتة وقريب من خمسين + +148 +00:13:16,520 --> 00:13:19,320 +تلاتة وقريب من خمسين تلاتة وقريب من خمسين تلاتة + +149 +00:13:19,320 --> 00:13:21,980 +وقريب من خمسين تلاتة وقريب من خمسين تلاتة وقريب من + +150 +00:13:21,980 --> 00:13:29,100 +خمسين تلاتة وقري + +151 +00:13:42,420 --> 00:13:48,240 +الفلوسة يمشي حسب السبب كمان لفلوسه لفوق. So at a + +152 +00:13:48,240 --> 00:13:51,160 +particular time, at a particular price + +153 +00:14:10,630 --> 00:14:13,410 +what it means بيه انت ناس معجن هارد و أربع يزيد + +154 +00:14:13,410 --> 00:14:16,430 +الفلوس يعني to add cash هيضيف cash يزيد الفلوس + +155 +00:14:16,430 --> 00:14:19,410 +تجيب الفلوس و هتضيف عارف ما اختلعت و to protect + +156 +00:14:19,410 --> 00:14:24,330 +his account otherwise .. otherwise يعني إذا أنا + +157 +00:14:24,330 --> 00:14:27,290 +صوّعش ال investors if the investors didn't listen + +158 +00:14:27,290 --> 00:14:32,990 +to the brokers in this case the broker has a right + +159 +00:14:32,990 --> 00:14:40,130 +to close his account or to sell off his position + +160 +00:14:44,420 --> 00:14:48,820 +هذا اللي انا بحكيه فيها يبسطه من الانتصار، يعني + +161 +00:14:48,820 --> 00:14:56,920 +لإيجاد الصيانة لازم يكون يعني معروف، كيف نحصل؟ + +162 +00:14:56,920 --> 00:15:02,000 +خلّينا احنا طريقة حسب الماضي و نتور منها في نفس + +163 +00:15:02,000 --> 00:15:02,720 +طريقة الحسب الماضي + +164 +00:15:07,430 --> 00:15:10,410 +طبعا كم ساعة؟ طبعا كم ساعة؟ طبعا كم ساعة؟ طبعا كم + +165 +00:15:10,410 --> 00:15:35,010 +ساعة؟ طبعا كم ساعة؟ طبعا كم ساعة؟ طبعا كم ساعة؟ + +166 +00:15:40,950 --> 00:15:44,950 +عشان نحسب ال margin هذا اللي احنا صممناه سابقا + +167 +00:15:44,950 --> 00:15:50,770 +فصدر 4 كده كل مرة طيب اللي اشد اللي احنا صارفه ان + +168 +00:15:50,770 --> 00:15:58,230 +في 100P 100 اللي هي أمرا و شاز دي مش معروف مارفس + +169 +00:15:58,230 --> 00:16:04,610 +اللي بقول انه 4 كده صح؟ اللي احنا اتطلبناه اغير لأ + +170 +00:16:04,610 --> 00:16:08,310 +لأ تفسير + +171 +00:16:08,940 --> 00:16:17,840 +اللي هو D بمية و B is the maintenance margin طب + +172 +00:16:17,840 --> 00:16:22,100 +الحالة هاللي تانية ميش مارجن او support ال + +173 +00:16:22,100 --> 00:16:26,200 +maintenance margin تصلق + +174 +00:16:26,200 --> 00:16:29,500 +هذا البرنامج اذا انا قطعتكم ال maintenance margin + +175 +00:16:29,500 --> 00:16:33,680 +كام يعني اجيال حكاية ال maintenance margin بساوي + +176 +00:16:33,680 --> 00:16:39,920 +قرر ان ال maintenance margin يساوي 30%يعني ال + +177 +00:16:39,920 --> 00:16:43,600 +maintenance margin تلاتين في المية يعني عن تلاتين + +178 +00:16:43,600 --> 00:16:46,840 +في المية طبعا هو هان خمسين اربعين عن تلاتين في + +179 +00:16:46,840 --> 00:16:51,460 +المية هان هيوقف ايش ال investment تبعه طبعا عنده + +180 +00:16:51,460 --> 00:16:55,260 +two option يا اما بجيب فلوس يا اما بسكله الحساب + +181 +00:16:55,260 --> 00:16:58,520 +هذا معناه ال maintenance margin طبعا انا بتبقى + +182 +00:16:58,520 --> 00:17:04,050 +عارف ال price كل اشي انا معروف عنده هانبس معادل ال + +183 +00:17:04,050 --> 00:17:07,110 +price مش معروف فإذا أنا عرفت ال price و كام لازم + +184 +00:17:07,110 --> 00:17:14,070 +واقفه فبتنحل المشكلة فهنا 30% انتبهوا معانا طبعا + +185 +00:17:14,070 --> 00:17:20,850 +طبعا هذه رياضية بسيطة بتصير خليكم + +186 +00:17:20,850 --> 00:17:28,910 +معانا فضرب تبادل يطلع 100 100P في .. okay يطلع + +187 +00:17:28,910 --> 00:17:29,390 +كام؟ + +188 +00:17:36,630 --> 00:17:41,630 +نقص من 4000 طبعا متأكدين ان ال maintenance margin + +189 +00:17:41,630 --> 00:17:50,290 +30% ال 30% ممن جبناها موجودة + +190 +00:17:50,290 --> 00:17:57,970 +في السؤال okay 30% طبعا بنحل احنا الموضوع ال 100B + +191 +00:17:57,970 --> 00:18:08,940 +من 30B بطلع 100B من .. عندنا ال .. كيف؟النية بي .. + +192 +00:18:08,940 --> 00:18:14,620 +لأ من .. طبعا هذه تلات .. تلاتين بي بتصير سبعين بي + +193 +00:18:14,620 --> 00:18:22,680 +okay بتساوي الأربع تلاف، مظبوط؟ وبعد هيك بتساوي + +194 +00:18:22,680 --> 00:18:30,460 +أربع تلاف تقسيم سبعين okay + +195 +00:18:34,580 --> 00:18:40,820 +طيب خلينا نشوف إيش الجواب تبعتهم 57 طيب بتلع + +196 +00:18:40,820 --> 00:18:46,660 +الجواب 57 اتطلعوا نرجع على ال .. نرجع على الحساب + +197 +00:18:46,660 --> 00:18:56,020 +تبعنا اتطلعوا على ال table طبعا السعر 70.50 بناتهم + +198 +00:18:56,020 --> 00:19:00,520 +هيكون هنا إيش يعملوا إيقاف لما يصل السعر على 57 + +199 +00:19:03,720 --> 00:19:09,060 +هيعمله stop investment او يحكيله please add more + +200 +00:19:09,060 --> 00:19:15,760 +cash او اضف لنا cash طبعا + +201 +00:19:15,760 --> 00:19:28,020 +هذا هو ال maintenance margin طب انا اسألوني + +202 +00:19:28,020 --> 00:19:31,860 +اذا في حد عنده سؤال لأ لسه في احنا هنطور شوية في + +203 +00:19:31,860 --> 00:19:32,200 +السؤال + +204 +00:19:36,020 --> 00:19:54,960 +57% 57% 57% 57% 57% 57% 57% 57% 57% 57% 57 + +205 +00:19:54,960 --> 00:20:04,260 +% + +206 +00:20:05,950 --> 00:20:15,290 +Okay فزي ما انتوا شايفين هان سبعة + +207 +00:20:15,290 --> 00:20:18,170 +و خمسين دولار فشوفتوا انتوا هان سبعة و خمسين دولار + +208 +00:20:18,170 --> 00:20:25,850 +اجت من ال ..ماشي + +209 +00:20:25,850 --> 00:20:28,290 +نعمل شوية تطوير على السؤال + +210 +00:20:34,080 --> 00:20:38,660 +بن .. السؤال بيحكي انه what is the price تبقى ل .. + +211 +00:20:38,660 --> 00:20:41,340 +this is a good question what .. what is the price + +212 +00:20:41,340 --> 00:20:47,680 +that the .. the dealer ask for maintenance ask for + +213 +00:20:47,680 --> 00:20:51,540 +maintenance for maintenance بتذكر ب chapter one + +214 +00:20:51,540 --> 00:20:55,520 +كنا نحكي بال broker call فاكرينه؟ اذا بترجعوا هذا + +215 +00:20:55,520 --> 00:21:00,500 +هو نفسه ال broker callفلما يصل عند .. طبعا هو مش + +216 +00:21:00,500 --> 00:21:04,680 +هيسأل .. مش هينتظر لما يصل سبعة و خمسين دولار، عند + +217 +00:21:04,680 --> 00:21:07,860 +ما يصل تمانية و خمسين، تسعة و خمسين فهو preparing + +218 +00:21:07,860 --> 00:21:13,760 +himself to call the investorهيحضر نفسه يتصل بال + +219 +00:21:13,760 --> 00:21:16,620 +investor be careful هيتصل فيه على ال mobile احكيله + +220 +00:21:16,620 --> 00:21:22,460 +okay be careful the price is now is 58 so if it + +221 +00:21:22,460 --> 00:21:28,560 +goes down 57 you may receive a margin call ايش a + +222 +00:21:28,560 --> 00:21:34,000 +margin call يعني حضر حالك اذا السعر الآن السعر 58 + +223 +00:21:34,000 --> 00:21:38,280 +اذا السعر وصل ل 57 و اقل احنا هنتصل فيك and + +224 +00:21:38,280 --> 00:21:43,120 +prepare your cash حضر ال cash تبعتكthis is what + +225 +00:21:43,120 --> 00:21:49,500 +the dealer is doing when the price close to the + +226 +00:21:49,500 --> 00:21:54,040 +fifty seven هذا الكلان هيسوي ال dealer لما السعار + +227 +00:21:54,040 --> 00:21:57,740 +تقترب لل fifty seven فهو مش هو not waiting until + +228 +00:21:57,740 --> 00:22:00,780 +the price is hit you know what means hit, hit يعني + +229 +00:22:00,780 --> 00:22:05,760 +تضرب بال fifty sevenjust one tick لما بحكي tick + +230 +00:22:05,760 --> 00:22:10,760 +يعني one tick before the fifty seven he may call + +231 +00:22:10,760 --> 00:22:16,840 +the investor one tick يعني مش بيسموها تك واحدة ال + +232 +00:22:16,840 --> 00:22:22,420 +prices لما بتعمل jump بتعمل jump by tick كل tick + +233 +00:22:22,420 --> 00:22:28,470 +مثلا دولار واحدSo one tick before the price يعني + +234 +00:22:28,470 --> 00:22:33,290 +tick واحدة مش احنا مرات بنقول بال tick اه ال tick + +235 +00:22:33,290 --> 00:22:37,470 +هذه معناها اللي هو قفزة واحدة للسعر يعني مثلا من + +236 +00:22:37,470 --> 00:22:41,070 +سبعة و خمسين تمانية و خمسين this is one tick So if + +237 +00:22:41,070 --> 00:22:45,810 +the price close one tick to the fifty seven the + +238 +00:22:45,810 --> 00:22:49,830 +investor may receive a margin call to prepare his + +239 +00:22:49,830 --> 00:22:51,490 +or her cash okay + +240 +00:22:55,800 --> 00:23:00,360 +نجرب 40% شو هيصير ال price according to فاطمة if + +241 +00:23:00,360 --> 00:23:05,760 +the .. if the .. if the maintenance margin is 40% + +242 +00:23:05,760 --> 00:23:11,220 +تطلع يا هان وين تتوقع السعر هيصير؟ يعني أنت بتحكي + +243 +00:23:11,220 --> 00:23:17,060 +هان 40% صح؟ هتكون قريبة لل 70 خلينا لو نجرب بلاش + +244 +00:23:17,060 --> 00:23:22,060 +.. نجرب 45% ال 45% هيقلع السعر من هنا نجربوا على + +245 +00:23:22,060 --> 00:23:29,100 +40% تعالوا تشوفوانجرب على اربعين في المية okay دوق + +246 +00:23:29,100 --> 00:23:33,100 +.. دوق jump to the conclusion خلينا نشوف 40 + +247 +00:23:33,100 --> 00:23:39,560 +percent طبعا بالحالة هيحصير اربعين P is equal one + +248 +00:23:39,560 --> 00:23:44,860 +hundred P minus forty thousands وبتساوي sixty P + +249 +00:23:44,860 --> 00:23:49,520 +four thousands وبالتالي P هتساوي four thousand + +250 +00:23:49,520 --> 00:23:56,160 +divided by sixtyبطلع ستة و ستين point فهيكون السعر + +251 +00:23:56,160 --> 00:24:05,720 +في المنطقة هذه okay that's it طيب احنا so far we + +252 +00:24:05,720 --> 00:24:09,080 +ignore the importance of the interest rate مظبوط + +253 +00:24:09,080 --> 00:24:13,720 +ولا لأ اتجاهلنا the rule of the interest rate now + +254 +00:24:13,720 --> 00:24:16,840 +in this example we will consider the importance of + +255 +00:24:16,840 --> 00:24:21,050 +interest rateهناخد بعين الاعتبار دور ال interest + +256 +00:24:21,050 --> 00:24:24,790 +rate عشان نحسب ال calculation of rate of return + +257 +00:24:24,790 --> 00:24:31,570 +طلعوا على المثال موجود في page 79 لو هذا ال + +258 +00:24:31,570 --> 00:24:37,070 +investor معايا؟ + +259 +00:24:37,070 --> 00:24:42,470 +okay لو هذا ال investor he + +260 +00:24:42,470 --> 00:24:49,370 +borrowed 10,000$ لو اتدين 10,000$from the investor + +261 +00:24:49,370 --> 00:24:55,650 +from the broker and the rest is covered by himself + +262 +00:24:55,650 --> 00:25:03,550 +والباقي غطى بنفسه يعني + +263 +00:25:03,550 --> 00:25:08,450 +أشهر تلاف دولار يعني بالمثال الأول ال buy and come + +264 +00:25:08,450 --> 00:25:11,750 +four thousand but in this example he bought ten + +265 +00:25:11,750 --> 00:25:15,110 +thousands and the rest is covered by himself + +266 +00:25:16,070 --> 00:25:21,390 +والباقي غطى بنفسه يعنى بيكون هنا ال fifty percent + +267 +00:25:21,390 --> 00:25:25,570 +مظبوط بيكون ال margin هنا fifty percent لأنه عشر + +268 +00:25:25,570 --> 00:25:28,850 +تلاف منه وعشر تلاف من ال broker طيب بدنا ناخد + +269 +00:25:28,850 --> 00:25:32,550 +three scenarios بدنا ناخد ايش three scenarios + +270 +00:25:32,550 --> 00:25:36,850 +three scenarios يعني three options او three + +271 +00:25:36,850 --> 00:25:40,720 +probabilities بدنا نشوف السعر اذا طلعوالسعر + +272 +00:25:40,720 --> 00:25:44,520 +ماتغيرش if the prices go down so we have three + +273 +00:25:44,520 --> 00:25:48,380 +scenarios if the prices go up if unchanged if the + +274 +00:25:48,380 --> 00:25:52,800 +prices go down so and see to observe the changes + +275 +00:25:52,800 --> 00:25:58,340 +خليني أشوف ال changes بال .. طيب a change in the + +276 +00:25:58,340 --> 00:26:02,260 +price 30 + +277 +00:26:02,260 --> 00:26:13,320 +% upيعني ارتفعت no change so it is zero so if it + +278 +00:26:13,320 --> 00:26:19,960 +is zero no change and thirty percent goes down + +279 +00:26:23,280 --> 00:26:29,180 +طريقة خيارات لتشوف ايش .. كيف بتأثر ال .. ال worth + +280 +00:26:29,180 --> 00:26:32,480 +تبع ال investors or retain on investments العادل + +281 +00:26:32,480 --> 00:26:36,880 +على الاستثمار في حالة ال .. الاسعار اتفقت في حالة + +282 +00:26:36,880 --> 00:26:42,280 +الأسعار ماتغيرتش في حالة الأسعار is going down طيب + +283 +00:26:42,280 --> 00:26:48,580 +نشوف مع نهاية السنة ال end of the year مع نهاية + +284 +00:26:48,580 --> 00:26:50,400 +السنة شو بيصير في الثروة .. في الثروة تبعته + +285 +00:26:53,570 --> 00:27:01,330 +لو ربح 30% عفوا لو الأسعار تفعل 30% كام بيربح؟ + +286 +00:27:01,330 --> 00:27:07,730 +انتوا حاسبوا لوحدكم هو الثروة تبعته حكينا عشر تلاف + +287 +00:27:07,730 --> 00:27:13,350 +تعونه خلوها بالهامش plus ten thousands أخدهم من ال + +288 +00:27:13,350 --> 00:27:20,020 +broker صح؟ فثروته كام صارت؟ عشرين ألفمظبوط احنا + +289 +00:27:20,020 --> 00:27:23,860 +بدأنا حكينا if he has ten thousand dollar and + +290 +00:27:23,860 --> 00:27:26,440 +borrowed ten thousand dollar from the broker so he + +291 +00:27:26,440 --> 00:27:31,120 +has twenty thousand dollar يعني هو عنده عشرين ألف + +292 +00:27:31,120 --> 00:27:34,880 +دولار العشرين ألف دولار هدول فيهم متين سهم يعني + +293 +00:27:34,880 --> 00:27:38,840 +شهري متين سهم فيه متساهم بالدولار هلأ خلينا نشوف + +294 +00:27:38,840 --> 00:27:42,920 +ال prices is go up thirty percent اذا الأسعار تفعت + +295 +00:27:42,920 --> 00:27:50,360 +thirty percent كم بيكون ربحان؟6000 صح بيقول ربحان + +296 +00:27:50,360 --> 00:27:56,940 +6000 so 6000 plus 20000 فهيقول عنده 26000 مع نهاية + +297 +00:27:56,940 --> 00:28:02,940 +السنة طبعا لو احنا فصلاهم 26000 عشر تلاف for the + +298 +00:28:02,940 --> 00:28:06,840 +investor عشر تلاف for the broker 6000 is the + +299 +00:28:06,840 --> 00:28:13,480 +profits forget ماتنسوش that he borrowed 10,000 + +300 +00:28:13,480 --> 00:28:21,450 +from the broker and 9%interest ما تنسوش أنه هو + +301 +00:28:21,450 --> 00:28:23,970 +ادّاين عشر طلعت من ال broker and this is not for + +302 +00:28:23,970 --> 00:28:29,090 +free و هذا مش البلاشة على الفائضة what is the + +303 +00:28:29,090 --> 00:28:32,690 +interest rate is nine percent و الفائضة كام تسعة + +304 +00:28:32,690 --> 00:28:38,770 +في الميزة okay طيب let's carry on خلينا نكمل so + +305 +00:28:38,770 --> 00:28:41,570 +far you understand what I mean here from where the + +306 +00:28:41,570 --> 00:28:44,510 +twenty six thousands comingit's coming from the + +307 +00:28:44,510 --> 00:28:47,550 +total worth twenty thousands plus the profits so + +308 +00:28:47,550 --> 00:28:50,670 +the profit twenty .. so the total amount is twenty + +309 +00:28:50,670 --> 00:28:54,130 +six thousands يعني لو احنا فصلناهم الستة و عشرين + +310 +00:28:54,130 --> 00:29:01,910 +الف هدول عشرة و عشرة و ستة عشر على ال broker و عشر + +311 +00:29:01,910 --> 00:29:06,660 +على ال investor و six ال profitthis is I asked + +312 +00:29:06,660 --> 00:29:12,500 +before ماحكيلها لك ربح ارتفع السوق كام تلاتية في + +313 +00:29:12,500 --> 00:29:16,340 +الميليون طب if the if if the price is there is no + +314 +00:29:16,340 --> 00:29:21,360 +changes in the price so twenty thousands if the if + +315 +00:29:21,360 --> 00:29:27,420 +the markets goes down if قداش حيخسر ستة ألف حيخسر + +316 +00:29:27,420 --> 00:29:31,580 +ستة ألف من العشرين ألف تبعته هصير عنده مش ألف + +317 +00:29:31,580 --> 00:29:35,120 +وأربعمية أربعتاشر ألف تمام؟ + +318 +00:29:40,010 --> 00:29:48,290 +طيب يا باشا okay very simple there is no need for + +319 +00:29:48,290 --> 00:29:52,290 +humming يعني مابتوتوش كتير احكوا directly the + +320 +00:29:52,290 --> 00:29:59,610 +questions to me which one هذي اه طيب ببساطة هلأ هو + +321 +00:29:59,610 --> 00:30:03,510 +كام عنده عشرين ألف عشرة منه و عشرة من ال broker + +322 +00:30:03,510 --> 00:30:09,670 +فصار عمره trade في السوقالسوق ارتفع ل 30% فاحنا + +323 +00:30:09,670 --> 00:30:16,470 +بدنا نحكي 30% time يعني ضرب ال 20 ألف كام؟ 6 ألف + +324 +00:30:16,470 --> 00:30:20,590 +ال 6 ألف زي الفروة ال 20 ألف اللي معاهي 26 ألف + +325 +00:30:20,590 --> 00:30:24,890 +that's it طبعا هذا صفر ماصارش تغير ضلت الفروة طبعا + +326 +00:30:24,890 --> 00:30:30,730 +هذا الخفضة الفروة طبعا okay هلا بدنا ناخد to + +327 +00:30:30,730 --> 00:30:33,590 +consider the interest rates خلينا نشوف + +328 +00:30:36,530 --> 00:30:41,530 +ال repayment بده يسد الفلوس لمين repayment + +329 +00:30:41,530 --> 00:30:46,890 +principal plus the interest بده يسد ال broker مصري + +330 +00:30:46,890 --> 00:30:54,050 +الفلوس و ما هي الفائدة طيب في الحالة الأولى طبعا + +331 +00:30:54,050 --> 00:30:57,550 +هيكون طبعا كام احسبولي كام الفلوس ال broker زائد + +332 +00:30:57,550 --> 00:31:00,970 +الفائدة كام عشر تلاف عشر تلاف عشر تلاف عشر تلاف + +333 +00:31:00,970 --> 00:31:01,410 +عشر تلاف عشر تلاف عشر تلاف عشر تلاف عشر تلاف عشر + +334 +00:31:01,410 --> 00:31:01,510 +تلاف عشر تلاف عشر تلاف عشر تلاف عشر تلاف عشر تلاف + +335 +00:31:01,510 --> 00:31:02,730 +عشر تلاف عشر تلاف عشر تلاف عشر تلاف عشر تلاف عشر + +336 +00:31:02,730 --> 00:31:02,730 +تلاف عشر تلاف عشر تلاف عشر تلاف عشر تلاف عشر تلاف + +337 +00:31:02,730 --> 00:31:07,080 +عشر تلاف عشر تلاف عشر تلاتبقوا يا بنات هان + +338 +00:31:07,080 --> 00:31:13,320 +الاستثمار ده بقى عشرين ألف صح؟ of them منهم ten + +339 +00:31:13,320 --> 00:31:16,880 +thousands for the investor عشرة الألف لل investors + +340 +00:31:16,880 --> 00:31:21,300 +and ten thousands to the broker شوف هو هو broker و + +341 +00:31:21,300 --> 00:31:26,240 +أنا investor I بيه ten thousand add لما نستخدم + +342 +00:31:26,240 --> 00:31:35,280 +كلمة add add يعني عند نسبة nine percentAdd nine + +343 +00:31:35,280 --> 00:31:38,780 +percent يعني هو أخد عشر تلاف دولار من ال broker + +344 +00:31:38,780 --> 00:31:42,980 +بنسبة تسعة في المية، أداش هيرجع لل broker، أداش + +345 +00:31:42,980 --> 00:31:47,760 +هيدفعله فلوس؟ لما بيسدوا كام هيسدوا؟ كيف حسبناها + +346 +00:31:47,760 --> 00:31:53,320 +عشر تلاف دولار؟ في عشر تلاف دولار، ten thousand + +347 +00:31:53,320 --> 00:31:56,980 +dollar هيand ten thousand dollar the ten thousand + +348 +00:31:56,980 --> 00:32:01,720 +is the broker is bought by from the broker and + +349 +00:32:01,720 --> 00:32:06,580 +nine percent is the interest so تسعة في المية في + +350 +00:32:06,580 --> 00:32:11,960 +عشر تلاف كم تسعمية دولار plus العشر تلاف هيسدوا كم + +351 +00:32:11,960 --> 00:32:16,480 +عشر تلاف تسعمية في كل الحلات هيسدوا عشر تلاف + +352 +00:32:16,480 --> 00:32:20,640 +تسعمية ولا هيختلف نفس الشيء + +353 +00:32:23,120 --> 00:32:29,200 +ماخستش خسر الربح مش مش شغلته اه so ten thousand + +354 +00:32:29,200 --> 00:32:34,680 +nine hundred okay so you understand so far no okay + +355 +00:32:34,680 --> 00:32:39,160 +now we want to calculate the investor rate of + +356 +00:32:39,160 --> 00:32:43,900 +return investor rate of return investor + +357 +00:32:52,310 --> 00:32:58,070 +rate of return يعني عاقد للمستثمر عاقد على الفلوس + +358 +00:32:58,070 --> 00:33:03,910 +المستثمر طيب تستطيعوا تحسبوها لحالكم بجيت البنات + +359 +00:33:03,910 --> 00:33:08,690 +قلنا rest of students خلينا + +360 +00:33:08,690 --> 00:33:11,450 +بس أعطيكوا two minutes خدوا two minutes ت + +361 +00:33:11,450 --> 00:33:18,210 +calculate the investor A على الدفتر لأول + +362 +00:33:18,210 --> 00:33:35,380 +حالةwe are to the first one then to the second إيش + +363 +00:33:35,380 --> 00:33:38,280 +القاعدة اللي هتستخدموها ساعدكم شوية بالقاعدة + +364 +00:33:38,280 --> 00:33:47,500 +استخدموا b1 minus c0 divided by b0 هدى ال return + +365 +00:33:48,810 --> 00:33:55,690 +Okay يلا نشوف مين يحسب ليها، تفضليها، استخدميها + +366 +00:33:55,690 --> 00:34:06,470 +أول + +367 +00:34:06,470 --> 00:34:09,990 +حاجة عندنا ستة و عشرين ألف اللي هي end of year كان + +368 +00:34:09,990 --> 00:34:14,570 +عندنا ستة و عشرين ألف، بنخسر منهم بتاع ال broker + +369 +00:34:14,570 --> 00:34:24,390 +اللي هو العشرة ثلاث وتسع ميةعشان نطبق ال .. عشان + +370 +00:34:24,390 --> 00:34:27,950 +نطبق + +371 +00:34:27,950 --> 00:34:31,290 +ال .. عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال + +372 +00:34:31,290 --> 00:34:31,290 +.. عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +373 +00:34:31,290 --> 00:34:31,430 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +374 +00:34:31,430 --> 00:34:31,510 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +375 +00:34:31,510 --> 00:34:32,490 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +376 +00:34:32,490 --> 00:34:33,090 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +377 +00:34:33,090 --> 00:34:36,290 +عشان نطبق ال .. عشان نطبق ال .. عشان نطبق ال .. + +378 +00:34:36,290 --> 00:34:46,170 +عشان نطبق ال .. عشان + +379 +00:34:46,170 --> 00:34:46,690 +نطبق ال + +380 +00:34:51,280 --> 00:34:57,960 +طبعا على ال .. على ال نفس الشغلة .. طبعا + +381 +00:34:57,960 --> 00:35:06,400 +بتطلع .. بتطلع fifty one percent .. كام؟ عنا + +382 +00:35:06,400 --> 00:35:10,340 +عشرين ألف .. هليا نشوف الثانية .. ثانية .. ثانية + +383 +00:35:10,340 --> 00:35:14,740 +.. fifty one percent يعني عنا ال 50% أكتر من نص + +384 +00:35:14,740 --> 00:35:19,400 +ربعي .. أكتر من نص تاريخي which is fineعشرين ألف + +385 +00:35:19,400 --> 00:35:26,260 +ناقص .. ناقص العشر تلاف وتسعمية تسعة تلاف ومية + +386 +00:35:26,260 --> 00:35:28,760 +تسعة تلاف ومية .. نعم تسعة تلاف ومية .. نعم تسعة + +387 +00:35:28,760 --> 00:35:29,640 +تلاف ومية .. نعم تسعة تلاف ومية .. نعم تسعة تلاف + +388 +00:35:29,640 --> 00:35:30,200 +ومية .. نعم تسعة تلاف ومية .. نعم تسعة تلاف ومية + +389 +00:35:30,200 --> 00:35:30,620 +.. نعم تسعة تلاف ومية .. نعم تسعة تلاف ومية .. نعم + +390 +00:35:30,620 --> 00:35:31,140 +تسعة تلاف ومية .. نعم تسعة تلاف ومية .. نعم تسعة + +391 +00:35:31,140 --> 00:35:34,540 +تلاف ومية .. نعم تسعة تلاف ومية .. نعم تسعة تلاف + +392 +00:35:34,540 --> 00:35:41,000 +ومية .. نعم تسعة تلاف ومية .. نعم تسعة تلاف ومية + +393 +00:35:41,000 --> 00:35:41,320 +.. ن + +394 +00:36:04,630 --> 00:36:05,750 +مش عارف بقى مش فاهم + +395 +00:36:14,120 --> 00:36:19,020 +هو خسر تحصل اربعتاشر الف فانا نقسم منهم العشر تلف + +396 +00:36:19,020 --> 00:36:30,100 +تسعمية ماهي + +397 +00:36:30,100 --> 00:36:38,140 +ال V1 شفرتين اللي هي تلت تلف تسعمية نقص العشر ألف + +398 +00:36:38,140 --> 00:36:40,460 +على العشر ألف + +399 +00:36:48,110 --> 00:36:55,970 +69% yes and he or she lost 69 percent of his + +400 +00:36:55,970 --> 00:37:04,450 +wealth well thank you very much yeah so the if you + +401 +00:37:04,450 --> 00:37:08,030 +calculate the interest or the rate of return + +402 +00:37:12,120 --> 00:37:17,420 +شكرا جزيلا لك مرة أخرى لإجابة هذا الفيديو و إذا + +403 +00:37:17,420 --> 00:37:32,780 +فقط قمت بإدخال ال 51% هنا و 9% و 69% فهذه + +404 +00:37:32,780 --> 00:37:40,920 +هي التخطيطات لرسالة عودة بعد الاستثمار في محافظة + +405 +00:37:40,920 --> 00:37:49,100 +المجموعاتحسنًا قبل أن تغادر تحاول تقرير اتجارات + +406 +00:37:49,100 --> 00:37:54,640 +الشراء التي هي الـ short sell كما أشرحت في ثلاث + +407 +00:37:54,640 --> 00:38:01,020 +مقابلات قبلها أشرح لك عندما يبدأ المستخدم بـ sell + +408 +00:38:01,020 --> 00:38:08,680 +فهنا المستخدم يبدأ بـ buy هو يدخل السوق أو يتعامل + +409 +00:38:08,680 --> 00:38:16,140 +في السوق بشركات الشراءin the other cases if the + +410 +00:38:16,140 --> 00:38:20,240 +investor engage in the market by selling أنا + +411 +00:38:20,240 --> 00:38:25,120 +وضحتلكوا إياها هذا الكلام صح؟ and we call this إيه + +412 +00:38:25,120 --> 00:38:31,140 +سمينا الكلام هذا؟ لأ إذا كان ال investor يدخل + +413 +00:38:31,140 --> 00:38:35,800 +بائع، بيكونش معاه فلوس، هو بيبيع، بيبدأ في بيع is + +414 +00:38:35,800 --> 00:38:39,120 +not .. he is starting by selling he borrow the + +415 +00:38:39,120 --> 00:38:44,750 +stock from the brokerwhat we call this process ايش + +416 +00:38:44,750 --> 00:38:49,610 +بتسميها هذا ال process short sell short sell so + +417 +00:38:49,610 --> 00:38:51,610 +our next meeting we will talk about the short sell + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/sKyveBLJSek_postprocess.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/sKyveBLJSek_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..bb029a43e6404b39febe32038749e36bf8288c53 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/sKyveBLJSek_postprocess.srt @@ -0,0 +1,2076 @@ +1 +00:00:26,900 --> 00:00:31,040 +بسم الله الرحمن الرحيم المرة الفاترة حكينا بال + +2 +00:00:31,040 --> 00:00:34,920 +price weighted average ال price weighted average + +3 +00:00:34,920 --> 00:00:39,740 +هي طريقة باستخدام التقييم المؤشر ال financial + +4 +00:00:39,740 --> 00:00:44,470 +index حكينا فيه طريقتين في ال price weightedوفي + +5 +00:00:44,470 --> 00:00:48,050 +اللي هو ال value market weighted المرة أخرى حكينا + +6 +00:00:48,050 --> 00:00:53,370 +عن ال price weighted طريقة التسعير بس فقط تعتمد + +7 +00:00:53,370 --> 00:00:57,030 +على ال pricing however the value weighted is + +8 +00:00:57,030 --> 00:01:04,030 +depend on the value of the shares يعني بتفرق عن ال + +9 +00:01:04,030 --> 00:01:07,710 +price weighted انه احنا بنضيف ال number of shares + +10 +00:01:07,710 --> 00:01:11,960 +على ال index ال index calculationsيعني المرة + +11 +00:01:11,960 --> 00:01:14,600 +الفاتة لما كنا نحكي ع ال price weighted كنا بس + +12 +00:01:14,600 --> 00:01:19,180 +نجمع ال price يعني مثلا إذا كان عندي a,b,c you + +13 +00:01:19,180 --> 00:01:32,820 +just sum the prices of a,b and c okay and Dow + +14 +00:01:32,820 --> 00:01:36,950 +Jones developed this and take the average of aب وC + +15 +00:01:36,950 --> 00:01:43,170 +هذا هو السعر الموضوع اليوم سأتحدث عن مؤسسة قيمة + +16 +00:01:49,500 --> 00:01:53,700 +So what is the difference between value market and + +17 +00:01:53,700 --> 00:01:58,900 +the price weighted؟يعني شو الفرق بين بنائس المؤشر + +18 +00:01:58,900 --> 00:02:04,700 +بطريق ال value يعني بقيمة المنشئة أو قيمة السوقية + +19 +00:02:04,700 --> 00:02:08,760 +المنشئة و الفرق بين التسعير؟ بال value market we + +20 +00:02:08,760 --> 00:02:11,420 +consider the number of shares + +21 +00:02:14,940 --> 00:02:18,420 +that outstanding by the company يعني بناخد بعين + +22 +00:02:18,420 --> 00:02:21,940 +الاعتبار عدد الأسهم اللى تم إصدارها من قبل الشركة + +23 +00:02:21,940 --> 00:02:28,980 +في عندكم بال .. على الصفحه انا نزلت how to + +24 +00:02:28,980 --> 00:02:33,420 +calculate the market value انا نزلتلكم كيف نحسب ال + +25 +00:02:33,420 --> 00:02:38,840 +market value okay الفرق + +26 +00:02:38,840 --> 00:02:41,060 +زى ما حكينا ان احنا ال price just we consider the + +27 +00:02:41,060 --> 00:02:48,200 +price لكن بال .. اه؟لأ موجود في الكتاب انت معاك + +28 +00:02:48,200 --> 00:02:52,040 +الكتاب ولا ال slides؟ okay في الكتاب موجود okay + +29 +00:02:52,040 --> 00:02:56,680 +بال .. بال price weighted we just consider the + +30 +00:02:56,680 --> 00:03:01,000 +price بال value markets we consider the number of + +31 +00:03:01,000 --> 00:03:04,220 +shares it means the price times by the number of + +32 +00:03:04,220 --> 00:03:08,740 +shares يعني احنا بنضرب ال price بعدد القسم number + +33 +00:03:08,740 --> 00:03:13,110 +of shares يعني عدد القسم okay نرجع لنفس المثالفي + +34 +00:03:13,110 --> 00:03:18,030 +عندنا شركتين زي ما انتوا شايفيهم شركة ABC و شركة + +35 +00:03:18,030 --> 00:03:26,710 +XYZ الكل شايف اه ال initial price يعني السعر بداية + +36 +00:03:26,710 --> 00:03:37,230 +بارح او بالامس كان 25$ ل ABC و 50$ ل XYZ باليوم + +37 +00:03:37,230 --> 00:03:42,590 +التاني ABC صارت 30$ و XYZ 45$ + +38 +00:03:46,670 --> 00:03:52,390 +number of shares number of shares يعني عدد القسم + +39 +00:03:52,390 --> 00:03:57,530 +عدد القسم ل ABC عشرين و عدد القسم ل XYZ اتنين + +40 +00:03:59,630 --> 00:04:02,170 +الخمسمية اللى جبناها ال initial value يعني قيمة + +41 +00:04:02,170 --> 00:04:06,990 +اول يوم او امبارح بتساوي اللى هو ال 25 ضرب number + +42 +00:04:06,990 --> 00:04:10,030 +of shares زى ما حكى ان ال number of shares ال + +43 +00:04:10,030 --> 00:04:14,510 +price ضرب number of shares يعني نضرب هذا النتيجة + +44 +00:04:14,510 --> 00:04:25,100 +بتساوي 25 ضرب 20 و هذه النتيجة 50 ضرب 2بتساوي اللي + +45 +00:04:25,100 --> 00:04:30,000 +هو ال one hundred ال 100 هذا ال price وهذا ال + +46 +00:04:30,000 --> 00:04:33,960 +number of shares ضربناهم طلع عندنا الجواب أخدنا + +47 +00:04:33,960 --> 00:04:40,080 +المجموع طلع عندنا خمسمية زي ستمية كم؟ ستمية هذا + +48 +00:04:40,080 --> 00:04:43,680 +لليوم اللي ايش؟ لامبارح لنافطر لان امبارح كان zero + +49 +00:04:43,680 --> 00:04:51,510 +امبارح يعني خلص zero اليوم oneيعني اليوم one, + +50 +00:04:51,810 --> 00:04:56,910 +tomorrow اتنين, تلاتة اربعة and so on نفس الشيء + +51 +00:04:56,910 --> 00:05:03,070 +ميكرر ال 600 ايش بتساوي السعر تلاتين ضربضارب + +52 +00:05:03,070 --> 00:05:05,930 +العشرين والخمسة واربعين ضارب التانية وخمسة واربعين + +53 +00:05:05,930 --> 00:05:10,290 +times two ninety ثلاثة times twenty six hundred we + +54 +00:05:10,290 --> 00:05:13,190 +end up with six hundred ninety أخدنا ست مائة و + +55 +00:05:13,190 --> 00:05:15,790 +تسعين و أخدنا ست مائة و تسعين يعني أنا باليوم من + +56 +00:05:15,790 --> 00:05:20,390 +بارح zero و هذا باليوم الأول today شوفنا كم يكون + +57 +00:05:20,390 --> 00:05:27,170 +فيه زيادة تسعين اليوم six ninety yesterday six + +58 +00:05:27,170 --> 00:05:30,310 +hundred so it means the index increased by ninety + +59 +00:05:30,310 --> 00:05:36,550 +okayطبعا هذا هو بناء ال index اول خطوة انه احنا + +60 +00:05:36,550 --> 00:05:40,550 +خلصنا ال .. طب ايش المعادلة لبناء ال index بعد ما + +61 +00:05:40,550 --> 00:05:43,410 +احنا ضربنا ال price ضرب ال times number of shares + +62 +00:05:43,410 --> 00:05:48,450 +نشوف المعادلة المعادلة في اي مؤشر لو انا بدأ احسب + +63 +00:05:48,450 --> 00:05:54,170 +ال index to any index لو انا بدأ احسب معادلة اي + +64 +00:05:54,170 --> 00:05:59,330 +مؤشر we have to decide at what point the index + +65 +00:05:59,330 --> 00:06:03,460 +should startand أي نقطة لازم المؤشر يبدأ في ناس + +66 +00:06:03,460 --> 00:06:07,080 +بيبدو المؤشر تبعهم مية دولار أو مية نقطة في ناس + +67 +00:06:07,080 --> 00:06:09,640 +بيبدوها بالألف في ناس بيبدوها بالعشرة ألاف في ناس + +68 +00:06:09,640 --> 00:06:14,140 +بيبدوها بالمليون okay so it depends on the + +69 +00:06:14,140 --> 00:06:17,220 +financial market committee يعني بتعتمد على قرار + +70 +00:06:17,220 --> 00:06:21,960 +قرار لجنة سوق الأوراق المالية انهم بيبدو المؤشر + +71 +00:06:21,960 --> 00:06:25,600 +بمية نقطة يعني مثلا احنا عندنا درجات الطلاب من مية + +72 +00:06:25,600 --> 00:06:29,620 +في ناس تانية مافيش عندهم مية في منهم a,b,c,dفي ناس + +73 +00:06:29,620 --> 00:06:32,140 +لأ مش من مية، في منهم من عشرة، في ناس من .. من + +74 +00:06:32,140 --> 00:06:35,400 +ألف، في ناس من عشرين، so it depends on the + +75 +00:06:35,400 --> 00:06:37,960 +regulations of the financial markets يعني مثلا + +76 +00:06:37,960 --> 00:06:40,680 +عندنا بال .. بال New York Stock Exchange عندهم بال + +77 +00:06:40,680 --> 00:06:45,300 +.. من مثلا من مائة ألف، بال .. عندنا بال .. بالألف + +78 +00:06:45,300 --> 00:06:48,480 +مثلا كانوا عشر تلاف عندنا سوق فلسطين أوراق المالية + +79 +00:06:48,480 --> 00:06:54,240 +اللي هو المؤشر القدس، مؤشر ال .. London Stock + +80 +00:06:54,240 --> 00:06:56,900 +Exchange اللي هو FTSE 100 بدأت بمائة ألف، so it + +81 +00:06:56,900 --> 00:07:01,190 +depends which you decidefor instance we decide by + +82 +00:07:01,190 --> 00:07:05,970 +one hundred احنا قررنا ان احنا نبدأ المؤشر بكم؟ + +83 +00:07:05,970 --> 00:07:13,630 +one hundred ضرب times B1 divided by B0 what is the + +84 +00:07:13,630 --> 00:07:19,370 +B1? B1 is the value today divided by the value + +85 +00:07:19,370 --> 00:07:23,710 +yesterday okay so the value today is six hundred + +86 +00:07:23,710 --> 00:07:29,320 +ninety the value of yesterday six hundred okaySo + +87 +00:07:29,320 --> 00:07:33,640 +the result is 115 + +88 +00:07:33,640 --> 00:07:41,640 +فالنتيجة بتطلع 115 بتطلع 115 خلنا + +89 +00:07:41,640 --> 00:07:47,260 +نكمل هلا طب اليوم zero اللي هو مبارح كام المفروض + +90 +00:07:47,260 --> 00:07:52,600 +يكون المؤشر بدأ بكم؟ يلا أشوفكممبارح المؤشر + +91 +00:07:52,600 --> 00:07:56,180 +المفروض يبدأ بكم؟ مؤشر كم لازم يبدأ؟ احنا قلنا انه + +92 +00:07:56,180 --> 00:07:59,700 +قررت اللجنة تبدأ ب 100 صح؟ اذا هاي 100، 100 من وين + +93 +00:07:59,700 --> 00:08:05,080 +اجت؟ لو احنا مبارح قلنا index is equal one hundred + +94 +00:08:05,080 --> 00:08:08,660 +times B not divided by B not لأنه بدأنا مبارح بس + +95 +00:08:08,660 --> 00:08:13,680 +حتى ساب المؤشر B not على B not one hundred times B + +96 +00:08:13,680 --> 00:08:17,320 +not six hundred divided by six hundred so it means + +97 +00:08:18,400 --> 00:08:22,660 +one hundred هاي ال one hundred okay this is to the + +98 +00:08:22,660 --> 00:08:29,640 +A one hundred fifteen إذا كام زاد المؤشر خمس عشر + +99 +00:08:29,640 --> 00:08:32,840 +نقطة خمس عشر نقطة تطلعوا على المؤشر هان هذا + +100 +00:08:32,840 --> 00:08:38,820 +بتشوفوه بالجزيرة بيكون أحمر نازل أخضر طالع فكم + +101 +00:08:38,820 --> 00:08:43,180 +ارتفع الأخضر خمس عشر هلأ لو إحنا بدينا نغير في + +102 +00:08:43,180 --> 00:08:46,660 +الأسعار يعني نفترض إنه إحنا زي ما إنتوا شايفين + +103 +00:08:46,660 --> 00:08:50,670 +نروح نغير في الأسعارنغير في أسعار مثلا ال final + +104 +00:08:50,670 --> 00:08:56,810 +value بدل ما هي السعر تلاتين صار أربعين شوفوا + +105 +00:08:56,810 --> 00:09:02,810 +مباشرة إيش راح يصير صار عندي كام المؤشر صار أكم + +106 +00:09:02,810 --> 00:09:09,690 +نقطة زاد طلعوا ع زيادة زيادة و انخفاض كام 48 طب لو + +107 +00:09:09,690 --> 00:09:15,710 +فكرنا أنه نخفض ال .. نخفض السعر نفترض أنه خمستاشر + +108 +00:09:15,710 --> 00:09:17,170 +فشو صار في المؤشر + +109 +00:09:20,960 --> 00:09:24,080 +انخفض في كام؟ خمس و تلاتين، خمس و تلاتين، خمس و + +110 +00:09:24,080 --> 00:09:24,300 +تلاتين، خمس و تلاتين، خمس و تلاتين، خمس و تلاتين، + +111 +00:09:24,300 --> 00:09:25,680 +خمس و تلاتين، خمس و تلاتين، خمس و تلاتين، خمس و + +112 +00:09:25,680 --> 00:09:25,940 +تلاتين، خمس و تلاتين، خمس و تلاتين، خمس و تلاتين، + +113 +00:09:25,940 --> 00:09:30,540 +خمس و تلاتين، خمس و تلاتين، خمس و تلاتين، خمس و + +114 +00:09:30,540 --> 00:09:33,920 +تلاتين، خمس و تلاتين، خمس و تلاتين، خمس و تلاتين، + +115 +00:09:33,920 --> 00:09:38,020 +خمس و تلاتين، خمس و تلاتين، خمس و تلاتين، خمس و + +116 +00:09:38,020 --> 00:09:42,450 +تلاتين،Okay هاي فكرة ال index هاي الفكرة مطبقة في + +117 +00:09:42,450 --> 00:09:46,750 +ال New York Stock Exchange مطبقة بسوق السوق New + +118 +00:09:46,750 --> 00:09:50,190 +York سوق الولايات المتحدة الأمريكية okay و + +119 +00:09:50,190 --> 00:09:54,290 +particularly S&P 500 هو المطبق هذه الفكرة يعني + +120 +00:09:54,290 --> 00:09:59,850 +باختصار أول خطوة بنعملها بنضرب ال price times the + +121 +00:09:59,850 --> 00:10:03,810 +number of shares price times number of shares for + +122 +00:10:05,090 --> 00:10:08,950 +the day which the index starts then the next day + +123 +00:10:08,950 --> 00:10:15,310 +and we apply this equation what this equation for + +124 +00:10:15,310 --> 00:10:18,630 +it calculates the index by points خدوا باقوا بال + +125 +00:10:18,630 --> 00:10:23,120 +point نحسبهابالنقاط يعني هذه الجواب مش 35 دولار + +126 +00:10:23,120 --> 00:10:27,620 +it's 35 points اذا انتوا بتسمعوا مثلا بال CNBC ولا + +127 +00:10:27,620 --> 00:10:32,260 +بالجزيرة they say it's decline 500 points or 300 + +128 +00:10:32,260 --> 00:10:35,780 +points يعني مابيحكوش انخفض الدولار او ترفع بال + +129 +00:10:35,780 --> 00:10:42,300 +points okay بنحسب ال index لليوم الأول for + +130 +00:10:42,300 --> 00:10:47,080 +instance و بنحسب ال index لليوم التالي one hundred + +131 +00:10:47,080 --> 00:10:53,350 +divided by oneone divided by by zero يعني نقسم + +132 +00:10:53,350 --> 00:10:57,770 +اللي احنا شوفناها ال final value divided by the + +133 +00:10:57,770 --> 00:11:00,810 +initial value ال final value يعني بتاعة اليوم ال + +134 +00:11:00,810 --> 00:11:03,850 +initial value أول ما بدأ المؤشر نقسم هذه على هذه + +135 +00:11:03,850 --> 00:11:09,650 +بطلع لنا الجواب هذا طبعا نطرحه من المية بطلع لنا + +136 +00:11:09,650 --> 00:11:15,020 +الفرحةOkay هذا المثال موجود عندكم بال .. بال web + +137 +00:11:15,020 --> 00:11:20,880 +page على الصفحة الشخصية so you go back and you can + +138 +00:11:20,880 --> 00:11:24,080 +just revise the calculations and see how it will + +139 +00:11:24,080 --> 00:11:36,460 +be calculated okay ب zero بارح okay + +140 +00:11:38,780 --> 00:11:44,700 +فاحنا حاكينا على ال .. كمان مرة نرجع أنه احنا we + +141 +00:11:44,700 --> 00:11:48,820 +have two methods to calculate the index فهنا + +142 +00:11:48,820 --> 00:11:53,340 +طريقتين لحساب ال index ال price methods and the + +143 +00:11:53,340 --> 00:11:56,940 +market value methods the main difference between + +144 +00:11:56,940 --> 00:12:00,300 +the price and the market value is the market value + +145 +00:12:00,300 --> 00:12:03,580 +calculated by times the price by the number of + +146 +00:12:03,580 --> 00:12:06,900 +shares and then you carry on calculations the + +147 +00:12:06,900 --> 00:12:11,660 +indexthere are other developments on how they + +148 +00:12:11,660 --> 00:12:16,100 +calculate the index but based on this level we + +149 +00:12:16,100 --> 00:12:20,900 +just know about the very simple methods in + +150 +00:12:20,900 --> 00:12:25,300 +calculating the index يعني في كتير طرق متطورة في + +151 +00:12:25,300 --> 00:12:29,000 +ال index في حساب ال index لكن احنا لهذا المستوى + +152 +00:12:29,000 --> 00:12:34,240 +فقط بناعطي هذه الطريقتين طريقة ال price وطريقة ال + +153 +00:12:34,240 --> 00:12:38,320 +market okay any question + +154 +00:12:43,550 --> 00:12:48,970 +المية بداية المؤشر بداية المؤشر بداية المؤشر بداية + +155 +00:12:48,970 --> 00:12:50,110 +المؤشر بداية المؤشر بداية المؤشر بداية المؤشر + +156 +00:12:50,110 --> 00:12:50,310 +بداية المؤشر بداية المؤشر بداية المؤشر بداية + +157 +00:12:50,310 --> 00:12:52,330 +المؤشر بداية المؤشر بداية المؤشر بداية المؤشر + +158 +00:12:52,330 --> 00:12:55,750 +بداية المؤشر بداية المؤشر بداية المؤشر بداية + +159 +00:12:55,750 --> 00:13:01,890 +المؤشر بداية + +160 +00:13:01,890 --> 00:13:05,670 +المؤشر بداية المؤشر بداية المؤشر بداية المؤشر + +161 +00:13:05,670 --> 00:13:06,950 +بداية المؤشر بداية المؤشر بداية المؤشر بداية + +162 +00:13:06,950 --> 00:13:07,430 +المؤشر بداية المؤشر بداية المؤشر بداية المؤشر + +163 +00:13:07,430 --> 00:13:07,510 +بداية المؤشر بداية المؤشر بداية المؤشر بداية + +164 +00:13:07,510 --> 00:13:13,460 +بداية المؤشرلو إجا بكرا هذا بيصير initial zero و + +165 +00:13:13,460 --> 00:13:17,160 +بكرا بيصير one فبصير أحسب one minus zero يعني + +166 +00:13:17,160 --> 00:13:21,380 +اليوم الجاى ناقص اليوم السابق فمتى كيف؟ هذه طريقة + +167 +00:13:21,380 --> 00:13:27,820 +حسبة مؤشر يعني مثلا لو إجينا مثلا نحكي tomorrow + +168 +00:13:27,820 --> 00:13:33,380 +tomorrow صار المؤشر tomorrow صار مؤشر eighty-five + +169 +00:13:33,380 --> 00:13:40,060 +بتصير هذه sixty-five yesterdayOkay C0 كم المؤشر + +170 +00:13:40,060 --> 00:13:45,140 +صار ارتفع ارتفع بقيمة عشرين نقطة بس بظل انه قيمة + +171 +00:13:45,140 --> 00:13:47,920 +المؤشر eighty five the value of the index is + +172 +00:13:47,920 --> 00:13:51,000 +eighty five لو احنا رجعنا لل origin what it means + +173 +00:13:51,000 --> 00:13:55,140 +eighty five from the origin from the first day of + +174 +00:13:55,140 --> 00:14:00,200 +the index it was one hundred ال + +175 +00:14:00,200 --> 00:14:04,830 +origin اول يوم انعمل فيه المؤشرأول يوم بدأنا فيه + +176 +00:14:04,830 --> 00:14:08,490 +المؤشر هذا اسمه ال initial price أول يوم عملنا فيه + +177 +00:14:08,490 --> 00:14:12,410 +المؤشر بعد هيك ال كل يوم بيصير يتغير بيصير يتغير + +178 +00:14:12,410 --> 00:14:20,210 +فبصير أنه أعمل كل يوم مع اليوم اللي قبله okay وين + +179 +00:14:20,210 --> 00:14:34,420 +المشكلة ال price و ال value عشان نحصل ال indexعشان + +180 +00:14:34,420 --> 00:14:39,100 +هو يساعدك to understandhow the financial market is + +181 +00:14:39,100 --> 00:14:42,620 +fluctuated كيف ال financial market تتحرك يعني + +182 +00:14:42,620 --> 00:14:47,060 +ماينفعش أروح أشوف كل الشركات يعني مثلا في ال S&D + +183 +00:14:47,060 --> 00:14:50,280 +500 في thousands of companies كيف أتعرف إنه ال + +184 +00:14:50,280 --> 00:14:53,160 +total تبع السوق ارتفع أو انخفض بدأ أروح أكل الشركة + +185 +00:14:53,160 --> 00:14:56,660 +و أحسبها فلازم يكون في عندي index هذا ال index + +186 +00:14:56,660 --> 00:15:00,760 +يعني زي pointer مؤشر بيحكي له إن الشركات انخفضت + +187 +00:15:00,760 --> 00:15:04,160 +أدائها أو ارتفع هذا ال benefits تبع ال index + +188 +00:15:07,490 --> 00:15:10,290 +يعني كيف انا بدأ أعرف أداء الطلاب، مانفعش أشيف كل + +189 +00:15:10,290 --> 00:15:14,030 +طالب إيش الأداء تبعه، لازم كلهم مع بعض، أخد عينة + +190 +00:15:14,030 --> 00:15:17,610 +منهم، sample و ال sample أعملها إلها indicator، ب + +191 +00:15:17,610 --> 00:15:20,590 +line عليها، بقرر إنه في انخفاض في أداء الطلاب أو + +192 +00:15:20,590 --> 00:15:27,790 +في ارتفاع في أداء الطلاب okay for + +193 +00:15:27,790 --> 00:15:32,650 +further detailsلمعلومات أكتر I will try to upload + +194 +00:15:32,650 --> 00:15:39,130 +some useful articles to understand in details + +195 +00:15:39,130 --> 00:15:44,750 +about the index أنتوا أكيد تسمعوا أخبار صح؟ أخبار + +196 +00:15:44,750 --> 00:15:48,530 +اقتصادية، ماسمعتوش .. ماسمعتوش بال .. بال Dow + +197 +00:15:48,530 --> 00:15:53,630 +Jones و بال .. بال .. خلاص ابدوا يسمعوا، ابدوا + +198 +00:15:53,630 --> 00:15:54,650 +يسمعوا أخبار اقتصادية + +199 +00:16:02,730 --> 00:16:08,670 +Okay نحكي على ال .. هاي .. بعض الأمثلة there are + +200 +00:16:08,670 --> 00:16:13,010 +some example on market index بعض الأمثلة على + +201 +00:16:13,010 --> 00:16:18,590 +الأسواق المؤشرات في عندنا ال S&P 500 هو مؤشر سوق + +202 +00:16:18,590 --> 00:16:23,490 +نيويورك broadly based index of 500 firms لما + +203 +00:16:23,490 --> 00:16:31,330 +بيحسبوا ال .. ال S&P 500بيجيبوا one ABCD till 500 + +204 +00:16:31,330 --> 00:16:37,030 +companies لعند 500 شركة و بيحسبوا بناء عليهم + +205 +00:16:37,030 --> 00:16:41,470 +المؤشر طبعا مين هم ال ABC هدول the best companies + +206 +00:16:41,470 --> 00:16:45,150 +based on market capitalization يعني هم أفضل شركات + +207 +00:16:45,150 --> 00:16:48,490 +حسب market capitalization و كمان بيضيفوا لشغل + +208 +00:16:48,490 --> 00:16:50,870 +market capitalization اللي هو ال liquidity و + +209 +00:16:50,870 --> 00:16:55,130 +profitability and other conditionsبضيفه يعني سيولة + +210 +00:16:55,130 --> 00:17:01,630 +الشركة والربح تبع الشركة إلى آخرين ال S&P500 + +211 +00:17:01,630 --> 00:17:04,510 +بتعتمد على الطريقة اللي احنا عملناها بشوية لو + +212 +00:17:04,510 --> 00:17:08,070 +market evaluated index بتعتمد على الطريقة اللي + +213 +00:17:08,070 --> 00:17:13,570 +احنا حلناها investors can base their portfolios on + +214 +00:17:13,570 --> 00:17:19,470 +the index ليش سألتني why the index is important + +215 +00:17:19,470 --> 00:17:24,890 +ليش ال index is importantthe answer is you don't + +216 +00:17:24,890 --> 00:17:27,570 +need to look for who is the best because the best + +217 +00:17:27,570 --> 00:17:31,150 +is there يعني مافي حاجة اللي احنا ندور مين الأحسن + +218 +00:17:31,150 --> 00:17:36,530 +لأن ال index is help us to categorize who is the + +219 +00:17:36,530 --> 00:17:40,860 +bestيعني ما .. مافيش داعي أروح أدور على أقرأ + +220 +00:17:40,860 --> 00:17:43,120 +تقارير الشركات وأعرف مين هو أحس .. مين أه .. هي + +221 +00:17:43,120 --> 00:17:47,000 +أحسن الشركة طالما أن المؤشر نفسه بيساعدني who is + +222 +00:17:47,000 --> 00:17:49,660 +the first ten, who is the first one hundred, who + +223 +00:17:49,660 --> 00:17:53,460 +is the first five hundred so I try to invest my + +224 +00:17:53,460 --> 00:17:58,580 +money on the .. the high quality corporationsأه + +225 +00:17:58,580 --> 00:18:01,800 +أنا بحاول أستثمر الأموال سبعتين في أفضل الشركات + +226 +00:18:01,800 --> 00:18:06,300 +يعني أنا مش بحاجة أروح أفتش على شركات جيدة طالما + +227 +00:18:06,300 --> 00:18:10,200 +is already أن الشركات موجودة جيدة يعني أنا مثلا في + +228 +00:18:10,200 --> 00:18:13,100 +سوق New York Stock Exchange فيه لدي ألاف الشركات + +229 +00:18:13,760 --> 00:18:16,740 +المؤشر هذا بيساعدني بيحكي له أنه مين أفضل الشركات + +230 +00:18:16,740 --> 00:18:20,840 +هذا أهمية بناء المؤشر طبعا المؤشر هذا فيه له + +231 +00:18:20,840 --> 00:18:24,340 +details مين هم الشركات just go to the S&P 500 + +232 +00:18:24,340 --> 00:18:28,240 +روحوا على ال S&P 500 ا click on the on the index + +233 +00:18:28,240 --> 00:18:31,360 +and you will see the number of shares and who are + +234 +00:18:31,360 --> 00:18:36,020 +the shares listed in the S&P 500 يعني روحوا على ال + +235 +00:18:36,020 --> 00:18:40,930 +S&P 500 اللي انا أعطيتكم إياه ال websiteروح على S + +236 +00:18:40,930 --> 00:18:45,490 +&P500 و اكتبوا constituent list of the S&P500 يعني + +237 +00:18:45,490 --> 00:18:50,270 +قائمة الشركات الموجودة في ال S&P 500 شركة and it + +238 +00:18:50,270 --> 00:18:53,030 +rank them according to the market capitalization + +239 +00:18:53,030 --> 00:18:55,550 +according to the liquidity and profitability + +240 +00:18:55,550 --> 00:18:59,570 +برتبوهم حسب القوة تبعتهم من ناحية القيمة السوقية و + +241 +00:18:59,570 --> 00:19:02,530 +الربحية و السيولة so why you are wasting your time + +242 +00:19:02,530 --> 00:19:06,270 +on looking for the companies ليش احنا نروح نضيع + +243 +00:19:06,270 --> 00:19:10,820 +وقتنا ان ندور على شركات and the index isRank them + +244 +00:19:10,820 --> 00:19:13,920 +لأن المؤشر هو نفسه يعني بيعطينا مين هو أفضل + +245 +00:19:13,920 --> 00:19:17,640 +الشركات So investors can base their portfolio on + +246 +00:19:17,640 --> 00:19:22,000 +an index يعني ممكن هم يعمل Portfolios محافظ بناء + +247 +00:19:22,000 --> 00:19:23,080 +على ال index + +248 +00:19:25,960 --> 00:19:28,760 +كيف بيعملوا كلان هذا buy and index mutual funds + +249 +00:19:28,760 --> 00:19:32,040 +فاكرين لما حكيت عن ال mutual funds بدل ما هم + +250 +00:19:32,040 --> 00:19:36,100 +الشركات ال insurance companies و ال mutual funds و + +251 +00:19:36,100 --> 00:19:40,880 +ال investment companies they don't have to spend a + +252 +00:19:40,880 --> 00:19:43,940 +lot of time on looking for companies فال mutual + +253 +00:19:43,940 --> 00:19:47,400 +funds بروحوا بريحوا راسهم they just only invest on + +254 +00:19:47,400 --> 00:19:51,920 +the companies listed on the on the indexبس بروحوا + +255 +00:19:51,920 --> 00:19:55,040 +باستثمروا في اللي موجودة بال index ال index had + +256 +00:19:55,040 --> 00:19:58,920 +every quarter is revised by the financial market + +257 +00:19:58,920 --> 00:20:03,140 +committee يعني هذا المؤشر يتم مراجعته كل ربع سنة + +258 +00:20:03,140 --> 00:20:06,680 +يعني كل ثلاث شهور ال financial committee يعني لجنة + +259 +00:20:06,680 --> 00:20:11,680 +الأوراق المالية بتقوم بمراجعة الشركات اللي في + +260 +00:20:11,680 --> 00:20:16,100 +المؤشر some companies leave the market and others + +261 +00:20:16,100 --> 00:20:20,270 +leave the index and others get in the indexيعني في + +262 +00:20:20,270 --> 00:20:23,670 +بعض الشركات بتروح من ال index و الشركات بتروح من + +263 +00:20:23,670 --> 00:20:27,790 +ضعف من ال index so the portfolio managers or the + +264 +00:20:27,790 --> 00:20:30,490 +marshall fund managers they rebalance their + +265 +00:20:30,490 --> 00:20:32,930 +portfolios according to the changes in the index + +266 +00:20:32,930 --> 00:20:37,270 +يعني بتلاقيهم بيعملوا تغيير في المحافظتهم حسب + +267 +00:20:37,270 --> 00:20:40,350 +التغير في ال index خلينا ناخد مثال بسيط لو كان أنا + +268 +00:20:40,350 --> 00:20:46,670 +عندي ال index just include A,B,Cالـ D ليس موجودا و + +269 +00:20:46,670 --> 00:20:51,450 +هذا الانديكس موجود فقط في 3 شركات و نحن لدينا D + +270 +00:20:51,450 --> 00:20:56,110 +نحن لدينا E نحن لدينا F J وكذلك يعني المؤشر بس + +271 +00:20:56,110 --> 00:21:00,770 +بحتوى على تلت شركات و احنا رتبنا وجدنا أفضل تلت + +272 +00:21:00,770 --> 00:21:05,750 +شركات اللي هو ABC بعد 3 أشهر بعد 3 أشهر بعد تلت + +273 +00:21:05,750 --> 00:21:11,880 +شهور نحن نحفظ هذا و بنعمل ranking و نجد ABA,B,E + +274 +00:21:11,880 --> 00:21:16,660 +بفاصة 3 So it means C will leave the market, the + +275 +00:21:16,660 --> 00:21:22,740 +index and we add up E بنضيف ال E بدلها So the + +276 +00:21:22,740 --> 00:21:31,000 +investors they replace C by E بيبدلوا ال C بال E + +277 +00:21:31,000 --> 00:21:35,320 +في المحفظة تبعكم أو في ال martial funds ليش؟ لأن + +278 +00:21:35,320 --> 00:21:39,200 +already the financial market or the index is + +279 +00:21:39,200 --> 00:21:46,430 +designedto help investors to categorize companies + +280 +00:21:46,430 --> 00:21:48,610 +based on the market capitalization based on the + +281 +00:21:48,610 --> 00:21:53,690 +liquidity based on the profitability يعني السوق + +282 +00:21:53,690 --> 00:21:57,810 +المالي بنى مؤشر عشان يساعد الناس يعرفوا مين + +283 +00:21:57,810 --> 00:22:01,270 +الشركات أول عشر شركات تانية عشر شركات and and so + +284 +00:22:01,270 --> 00:22:04,870 +on so you don't need to waste your time on looking + +285 +00:22:04,870 --> 00:22:08,350 +for or searching of the best companies + +286 +00:22:12,080 --> 00:22:19,360 +Okay كيف؟ لأ كانوا a و b و c okay بعدين صارت a و d + +287 +00:22:19,360 --> 00:22:25,820 +و e صارت a و b و e صارت .. هلا عملنا لهم ranking + +288 +00:22:25,820 --> 00:22:31,760 +وجدنا أنه حسب ال ranking a و b و e أفضل ف why .. + +289 +00:22:31,760 --> 00:22:37,060 +why you are keeping c إذا .. إذا .. ه .. وبالتالي + +290 +00:22:37,060 --> 00:22:41,620 +هتطلع من ال index هنروح نبدلها ب eفال investors + +291 +00:22:41,620 --> 00:22:50,540 +..الان السوق قرر ان a و b ايه the best؟ ال index، + +292 +00:22:50,540 --> 00:22:55,660 +هذي ال index، هاي ال index okay؟ هلأ انت عندك + +293 +00:22:55,660 --> 00:22:58,760 +portfolio، you are mimicking the index، you are + +294 +00:22:58,760 --> 00:23:02,830 +mimicking the index، what it means mimicking؟يعني + +295 +00:23:02,830 --> 00:23:06,870 +احنا بنقلد ال index لأنه بنعرف ان ال index هم أفضل + +296 +00:23:06,870 --> 00:23:11,290 +الناس فبروحش بنسوي بنستثمر في ال index mimicking + +297 +00:23:11,290 --> 00:23:15,910 +or copying انا معايا فلوس بروح بقلد ال index لما + +298 +00:23:15,910 --> 00:23:19,230 +قلدت ال index في المرحلة الأولى كان a,b,c هلأ لما + +299 +00:23:19,230 --> 00:23:26,610 +اتغير صار a,b,e و بتسهل لازم ارفع ال c و أحط a,b,e + +300 +00:23:26,610 --> 00:23:31,390 +و بضيف ال e in this case ال investors are selling + +301 +00:23:32,440 --> 00:23:38,960 +بيبيعوا C and buying E بيبيعوا ال C و بيشتريوا ال + +302 +00:23:38,960 --> 00:23:42,660 +E عشان يعرفوا انه نفسهم and they are mimicking + +303 +00:23:42,660 --> 00:23:52,040 +mimicking or copying mimicking mimic يقلد + +304 +00:23:52,040 --> 00:23:57,120 +mimicking the index or copying the index يحاولوا + +305 +00:23:57,120 --> 00:24:00,440 +ان يقلدوا ال index عشان يشتريوا راسهم بدون مش + +306 +00:24:00,440 --> 00:24:01,100 +مشاكل okay + +307 +00:24:04,920 --> 00:24:11,160 +شمالهم ال investors مثلا okay انا + +308 +00:24:11,160 --> 00:24:13,780 +مش عارفة انا لأ بتكون شارية مثلا انا مش حابب ال .. + +309 +00:24:13,780 --> 00:24:23,340 +okay read it okay go home and read it سهلة + +310 +00:24:23,340 --> 00:24:30,680 +انتبهوا معاها هلا احنا في عندنا طلاب اختارنا افضل + +311 +00:24:30,680 --> 00:24:35,760 +تلات طالباتتمام؟ هدول أخدناهم ال benchmark تبعنا + +312 +00:24:35,760 --> 00:24:40,660 +ايش ال benchmark؟ benchmark يعني بقياس هلأ كل تلات + +313 +00:24:40,660 --> 00:24:45,300 +شهور بنعمل مراجعة للصف لأن أفضل تلات شهور .. تلات + +314 +00:24:45,300 --> 00:24:48,120 +.. واحدة كسرت من البنات زي ما حكت بنستبدلها بواحدة + +315 +00:24:48,120 --> 00:24:52,540 +أخرى وبالتالي ال benchmark تبعنا بيصير الطالبتين + +316 +00:24:52,540 --> 00:24:55,260 +اللي ضالهم زائد الطالبة اللي كسرت أخدنا واحدة + +317 +00:24:55,260 --> 00:24:59,200 +بدلها هلأ أنا as investors هذا ال market هيك as + +318 +00:24:59,200 --> 00:25:03,500 +investorsbecause there is a change in the index فى + +319 +00:25:03,500 --> 00:25:07,840 +تغير فى ال index صار so I'm try to copy this بحاول + +320 +00:25:07,840 --> 00:25:13,840 +أنا أقلد أقلدهم عندهم كان أول a و b و c بعد تلت + +321 +00:25:13,840 --> 00:25:18,380 +شهور راحوا راجعوا ال index صار عندهم a و b و e أنا + +322 +00:25:18,380 --> 00:25:22,280 +ك investors still عندي a و b و c لكن because I'm + +323 +00:25:22,280 --> 00:25:25,240 +mimicking the index لأنه أنا بتقلد هذا so I have + +324 +00:25:25,240 --> 00:25:32,300 +to sell c and buy eلازم أبيع ال C because C is + +325 +00:25:32,300 --> 00:25:36,920 +less equality or the least equality أقل جودة so + +326 +00:25:36,920 --> 00:25:43,040 +leave it and bring the new company سيبوها و جيبوا + +327 +00:25:43,040 --> 00:25:49,490 +الشركة الجديدة okay for more understandinggo to + +328 +00:25:49,490 --> 00:25:53,530 +science direct and quote my name اكتبوا اسمي + +329 +00:25:53,530 --> 00:26:00,670 +هتجدوا في two three articles explain how this work + +330 +00:26:00,670 --> 00:26:02,910 +روح على science direct www + +331 +00:26:15,060 --> 00:26:17,780 +بتيجيكوا www.sciencedirect.com ادخلوا عليها + +332 +00:26:17,780 --> 00:26:22,920 +بيجيكوا ال author اكتبوا اسمه حيجيكم some articles + +333 +00:26:22,920 --> 00:26:27,940 +بعض ال articles بعض الأبحاث show you how how the + +334 +00:26:27,940 --> 00:26:32,660 +index is built كيف ال index بنعمل هذا للناس اللي + +335 +00:26:32,660 --> 00:26:37,440 +بدها information يعني بدها معلومات by + +336 +00:26:37,440 --> 00:26:42,730 +index we have timebuy exchange traded funds buy + +337 +00:26:42,730 --> 00:26:45,930 +exchange traded funds I will explain this in next + +338 +00:26:45,930 --> 00:26:48,990 +chapter which is related to the mutual funds + +339 +00:26:48,990 --> 00:26:56,570 +exchange traded funds it means it looks like the + +340 +00:26:56,570 --> 00:27:01,730 +mutual funds تشبه صناديخ الاستثمارOkay they adjust + +341 +00:27:01,730 --> 00:27:07,190 +some investors they create small portfolios and + +342 +00:27:07,190 --> 00:27:10,550 +they rebalance these portfolios according to the + +343 +00:27:10,550 --> 00:27:13,670 +changes in the index يعني بعض المستثمرين بيوجدوا + +344 +00:27:13,670 --> 00:27:16,730 +هذه المحافظة الصغيرة و هذه المحافظة الصغيرة بتكون + +345 +00:27:16,730 --> 00:27:20,910 +تقلد ال index و أيش بيستغير بال index هم بيحاولوا + +346 +00:27:20,910 --> 00:27:26,070 +يغيروا في ال portfolios تبعتهم other indexes + +347 +00:27:26,070 --> 00:27:30,330 +مؤشرات أخرىفي عندنا other indexes، في عندنا New + +348 +00:27:30,330 --> 00:27:34,090 +York Stock Exchange Composite، في عندنا Nasdaq + +349 +00:27:34,090 --> 00:27:39,590 +Composite، ال .. ال Nasdaq هذا مؤشر صناعي، مؤشر + +350 +00:27:39,590 --> 00:27:43,090 +مهم و هذا يعتبر من تاني أكبر سوق في الولايات + +351 +00:27:43,090 --> 00:27:49,320 +المتحدة الأمريكية، عندنا الاخدوا معلومات عنهم يعني + +352 +00:27:49,320 --> 00:27:53,400 +اعرفوهم بس Wilshire 5000 يعني مش هاسألكم عنهم كتير + +353 +00:27:53,400 --> 00:27:57,920 +ال foreign indexes غير الولايات المتحدة الأمريكية + +354 +00:27:57,920 --> 00:28:01,760 +في مؤشر ال Nikkei هذا مؤشر مهم بتاع Japan بتاع + +355 +00:28:01,760 --> 00:28:05,420 +اليابان مؤشر Tokyo في عندنا ال Fotsi one hundred + +356 +00:28:05,420 --> 00:28:10,280 +ال Fotsi تبع لندن طبعا هذا بيشمل تقريبا 25% من + +357 +00:28:10,280 --> 00:28:14,600 +الشركات في العالمعنا ال bags تبع ألمانيا وفي عندنا + +358 +00:28:14,600 --> 00:28:17,400 +ال hang sing تبع هونج كونج وفي عندنا ال TSX تبع + +359 +00:28:17,400 --> 00:28:20,840 +كندا في عندنا ال TSE تبع أستنبول stock exchange, + +360 +00:28:21,100 --> 00:28:25,220 +we have TAV تبع تل أفيف وعندنا القدس تبع ال في + +361 +00:28:25,220 --> 00:28:30,220 +Alexandria and Cairo in Egypt, we have in Amman, + +362 +00:28:30,380 --> 00:28:38,280 +Jordan, we have the Karachi in PakistanYou have + +363 +00:28:38,280 --> 00:28:43,780 +many indices in the world any financial markets + +364 +00:28:43,780 --> 00:28:48,220 +have to have index مافيششي financial market مايله + +365 +00:28:48,220 --> 00:28:53,880 +index okay سواء كان CAC, CAC40, DAGs ولا كان + +366 +00:28:53,880 --> 00:28:57,940 +Nikkei ولا كان Dow Jones ولا كان S&P500 and + +367 +00:28:57,940 --> 00:29:05,150 +derivative markets I think II talk about the + +368 +00:29:05,150 --> 00:29:10,710 +derivative markets اللي هو أسواق المشتقات أسواق + +369 +00:29:10,710 --> 00:29:15,330 +المشتقات derivatives + +370 +00:29:15,330 --> 00:29:19,840 +as I explained before in the in chapter oneزي ما + +371 +00:29:19,840 --> 00:29:23,780 +احنا حكينا ب chapter one, we have options, we have + +372 +00:29:23,780 --> 00:29:27,080 +future, we have swap and we have forwards فى عندنا + +373 +00:29:27,080 --> 00:29:29,700 +هدول الأربع أنواع، so I'm not going in details + +374 +00:29:29,700 --> 00:29:34,860 +about this because we will have more details in + +375 +00:29:34,860 --> 00:29:37,520 +the chapters, no, today I'm going to finish this + +376 +00:29:37,520 --> 00:29:40,480 +chapter options and futures provide payoff that + +377 +00:29:40,480 --> 00:29:43,000 +depend on the values of other assets, we explain + +378 +00:29:43,000 --> 00:29:48,070 +thisit means the value of options or the value of + +379 +00:29:48,070 --> 00:29:52,070 +derivatives is derived from the financial assets + +380 +00:29:52,070 --> 00:29:58,610 +particularly the derivatives invested in the + +381 +00:29:58,610 --> 00:30:01,550 +changes of the price يعني ال derivatives المشتقات + +382 +00:30:01,550 --> 00:30:06,570 +فقط بتستثمر في الأسعار ما بتستثمر في ال real + +383 +00:30:06,570 --> 00:30:10,270 +assets a derivative is a security that gets its + +384 +00:30:10,270 --> 00:30:12,390 +value from the value of another asset and we + +385 +00:30:12,390 --> 00:30:16,360 +explained thisthe first one in the option option + +386 +00:30:16,360 --> 00:30:20,420 +have two types في عندنا ال call و في عندنا ال bot + +387 +00:30:20,420 --> 00:30:23,140 +في عندنا نوعين من ال .. من ال options الخيارات في + +388 +00:30:23,140 --> 00:30:26,020 +عندنا ال call option و في عندنا ال bot option ال + +389 +00:30:26,020 --> 00:30:28,260 +call option you are buyer و ال bot option you are + +390 +00:30:28,260 --> 00:30:31,220 +seller يعني ال call option أنت بتشتري في ال buy + +391 +00:30:31,220 --> 00:30:35,620 +option you are بتبيع يعني في الأولى أنت بتشتري و + +392 +00:30:35,620 --> 00:30:39,460 +في الثانية احنا بنبيعand the definition is right + +393 +00:30:39,460 --> 00:30:42,080 +to buy underlying asset at the strike or exercise + +394 +00:30:42,080 --> 00:30:45,760 +price strike or exercise price هو لسعر التثبيت + +395 +00:30:45,760 --> 00:30:49,620 +يعني زي ما احنا حكينا انه بنثبت سعر يعني مثلا + +396 +00:30:49,620 --> 00:30:55,360 +بنشتري stock ايه على تلاتين دولار but this is in + +397 +00:30:55,360 --> 00:31:01,500 +the futureso the strike price is 30 we have to pay + +398 +00:31:01,500 --> 00:31:05,500 +a premium دفترض انه two dollar so the price the + +399 +00:31:05,500 --> 00:31:09,620 +strike price 30 plus two which is equal 32 it + +400 +00:31:09,620 --> 00:31:11,920 +doesn't matter it doesn't matter what is the price + +401 +00:31:11,920 --> 00:31:14,680 +in the future مابيعنناش ايش السعر في المستقبل we + +402 +00:31:14,680 --> 00:31:19,520 +fix the price على 32 30 plus two two is the + +403 +00:31:19,520 --> 00:31:23,620 +premiumjust go back to the chapter one and you + +404 +00:31:23,620 --> 00:31:26,280 +will understand how it works value of calls + +405 +00:31:26,280 --> 00:31:31,380 +decrease as strike prices increase ال value of + +406 +00:31:31,380 --> 00:31:36,200 +calls decrease قيمة ال call اللي هو الشراء بتنخفض + +407 +00:31:36,200 --> 00:31:41,680 +كل ما زاد سعر ال option + +408 +00:31:41,680 --> 00:31:49,640 +okay and the opposite البط عكسه تماما البط هي + +409 +00:31:49,640 --> 00:31:55,040 +البيعيعني مثلا انا حكيت انه بدى اشتري السعر على 32 + +410 +00:31:55,040 --> 00:32:00,120 +في واحد بالطرف الآخر ببيع بده يعمل اللي هو bought + +411 +00:32:00,120 --> 00:32:03,860 +option اللي هو بيع ال bought option is right to + +412 +00:32:03,860 --> 00:32:07,060 +sell careful here right to buy and right to sell + +413 +00:32:07,060 --> 00:32:13,460 +يعني احنا بدنا نبيع السهم طب هلأ اللي بده يبيع + +414 +00:32:13,460 --> 00:32:21,190 +السهم بخاف السهم ينخفض ولا يرتفعينخفض so he go to + +415 +00:32:21,190 --> 00:32:24,870 +the option market to hedge against the decrease of + +416 +00:32:24,870 --> 00:32:29,910 +the financial markets عشان يتحوط ضد الانخفاض يعني + +417 +00:32:29,910 --> 00:32:32,750 +الناس اللي بيروحوا على ال bot option بيروحوا عشان + +418 +00:32:32,750 --> 00:32:37,750 +يتحوطوا ضد انخفاض السعر الناس اللي بدخلوا بال call + +419 +00:32:37,750 --> 00:32:45,050 +option هم بتحوطوا ضد ارتفاع السعر يعني عكس بعضand + +420 +00:32:45,050 --> 00:32:48,790 +again try to sell underlying asset at the strike + +421 +00:32:48,790 --> 00:32:53,230 +or exercise price طبعا بتفق مع بعض انا برضه انه + +422 +00:32:53,230 --> 00:32:59,310 +السعر مثلا تلاتين اذا كان ال strike بس هنا ال + +423 +00:32:59,310 --> 00:33:04,950 +premium بتسميها discount خصم يعني اذا كانت هنا + +424 +00:33:04,950 --> 00:33:07,970 +premium ده تكون هنا ايش discount بدل ما هي تلاتين + +425 +00:33:07,970 --> 00:33:16,620 +بتصير كام تمانية و عشرينبس هذا هو الفرق value + +426 +00:33:16,620 --> 00:33:21,180 +of bots increase with the strike price يعني هنا + +427 +00:33:21,180 --> 00:33:26,080 +قيمة ال bots بتنخفض بتزيد بس هنا قيمة ال call + +428 +00:33:26,080 --> 00:33:31,760 +بتزيد عكسهم تماما المهم + +429 +00:33:35,080 --> 00:33:39,300 +المهم نفهم بال .. بال options بال options ال call + +430 +00:33:39,300 --> 00:33:43,120 +options و ال bot option ال call يعني شراء ال bot + +431 +00:33:43,120 --> 00:33:47,800 +هو بيع بال call option أنه أنا بدخل ضد ارتفاع + +432 +00:33:47,800 --> 00:33:51,320 +الأسعار بال bot option أنا بدخل ضد انخفاض الأسعار + +433 +00:33:51,320 --> 00:33:59,460 +ال futures ال futures هي تشبه ال option يعني هاي + +434 +00:33:59,460 --> 00:34:04,440 +المستقبلية تشبه ال optionوكمان حكيناها ب chapter + +435 +00:34:04,440 --> 00:34:08,380 +one لكن الفرق هي مافيش فيه premium و مافيش فيها + +436 +00:34:08,380 --> 00:34:13,800 +discount مافيش فيه علاوة خلاص نتسبت سعر نفترض ان + +437 +00:34:13,800 --> 00:34:18,060 +احنا سبتناها تلاتين there + +438 +00:34:18,060 --> 00:34:21,740 +is no premium there is no discount خلاص and we + +439 +00:34:21,740 --> 00:34:27,200 +have to exerciseو لازم احنا ننفذ بال option why it + +440 +00:34:27,200 --> 00:34:30,300 +is called option because we have to exercise or + +441 +00:34:30,300 --> 00:34:36,900 +not يعني اننا حق ننفذ او لأ اذا ما نفذناش بتروح + +442 +00:34:36,900 --> 00:34:40,140 +علينا ال premium or ال discount but in the future + +443 +00:34:40,140 --> 00:34:44,540 +you have to exercise exercise يعني ننفذ يعني ال + +444 +00:34:44,540 --> 00:34:48,500 +future لازم احنا ننفذ a future contract calls for + +445 +00:34:48,500 --> 00:34:55,220 +delivery of an assetsat a specific time a specific + +446 +00:34:55,220 --> 00:34:58,380 +delivery or maturity date for an agreed upon price + +447 +00:34:58,380 --> 00:35:01,360 +called the future price to be paid at the contract + +448 +00:35:01,360 --> 00:35:09,480 +maturity يعني مثلا في ال future ثبتنا السعر تلاتين + +449 +00:35:09,480 --> 00:35:14,420 +ثبتناه هلا نبدأ نشوف إيش الأسعار هتصير في اليوم + +450 +00:35:14,420 --> 00:35:19,290 +الأول التاني التالت الرابع till the maturityال + +451 +00:35:19,290 --> 00:35:23,330 +maturity ايش ال maturity يعني الاستحقار هلأ بنشوف + +452 +00:35:23,330 --> 00:35:27,790 +السعر السعر صار thirty one طب عم نحسب ال profit و + +453 +00:35:27,790 --> 00:35:33,510 +المال PL الربح و الخسارة تلاتين خسرنا ولا ربحنا + +454 +00:35:33,510 --> 00:35:39,230 +ربحنا واحد طيب تاني يوم صارت نفترض تسعة و عشرين + +455 +00:35:39,230 --> 00:35:45,170 +اتنين و تلاتين خمس و تلاتين تمانية و عشرين و هتزا + +456 +00:35:45,170 --> 00:35:50,830 +اليوم التانيتسعة و عشرين خسرنا واحد minus one لو + +457 +00:35:50,830 --> 00:35:55,790 +أجينا احنا عاملنا balance هيك balance هنا ربح one + +458 +00:35:55,790 --> 00:36:01,810 +هنا zero يعني ربحنا واحد و خسرنا واحد zero طيب + +459 +00:36:01,810 --> 00:36:05,570 +باليوم التاسعة اتنين و تلاتين ربحنا اتنين دايما + +460 +00:36:05,570 --> 00:36:09,390 +على exercise ربحنا اتنين ال balance تبعتنا اتنين + +461 +00:36:09,390 --> 00:36:14,530 +خمسة و تلاتين ربحنا five فال balance تبعنا بيصير + +462 +00:36:14,530 --> 00:36:20,320 +كان sevenخمسة و اتنين سبعة هلأ ال تمانية و عشرين + +463 +00:36:20,320 --> 00:36:25,900 +خسرنا تمانية و عشرين minus twoبيظل معنا خمسة and + +464 +00:36:25,900 --> 00:36:29,360 +so on اخر ال maturity date بيحسبوا كم احنا ربحنا + +465 +00:36:29,360 --> 00:36:31,480 +او خسرنا and they give it to the investors + +466 +00:36:31,480 --> 00:36:35,660 +وبيعطوها لل investors باخر اليوم بيحسبوا كم ربحنا + +467 +00:36:35,660 --> 00:36:39,260 +او خسرنا وبالتالي بيقدروا طبعا انتوا مالكمش بال + +468 +00:36:39,260 --> 00:36:42,420 +balance لان I think you may get confused from + +469 +00:36:42,420 --> 00:36:45,460 +understanding the balance just understand the + +470 +00:36:45,460 --> 00:36:48,620 +profit and loss يعني بدكم تعرفوا كيف الربح و + +471 +00:36:48,620 --> 00:36:53,600 +الخسارة طيب + +472 +00:36:55,910 --> 00:37:00,290 +احنا في ال future contract بناخد شغلة اسمة long + +473 +00:37:00,290 --> 00:37:06,770 +position و short position البناس مش مطلوب منك بس + +474 +00:37:06,770 --> 00:37:12,230 +كيف حسبتي بتروح بتجمع هدول واحد واحد واحد ناقص + +475 +00:37:12,230 --> 00:37:16,490 +واحد سفر سهل واحد ناقص واحد سفر و اتنين اتنين واحد + +476 +00:37:16,490 --> 00:37:20,530 +ناقص واحد سفر و اتنين و خمسة سبعة بس جمعيهم جمع + +477 +00:37:20,530 --> 00:37:24,160 +عاديأنا صار سبعة و انا انا انا انا انا انا انا انا + +478 +00:37:24,160 --> 00:37:25,320 +انا انا انا انا انا انا انا انا انا انا انا انا + +479 +00:37:25,320 --> 00:37:25,720 +انا انا انا انا انا انا انا انا انا انا انا انا + +480 +00:37:25,720 --> 00:37:30,140 +انا انا انا انا انا انا انا انا انا + +481 +00:37:30,140 --> 00:37:30,260 +انا انا انا انا انا انا انا انا انا انا انا انا + +482 +00:37:30,260 --> 00:37:33,980 +انا انا انا انا انا انا انا انا انا انا انا انا + +483 +00:37:33,980 --> 00:37:34,000 +انا انا انا انا انا انا انا انا انا انا انا انا + +484 +00:37:34,000 --> 00:37:34,560 +انا انا انا انا انا انا انا انا انا انا انا انا + +485 +00:37:34,560 --> 00:37:51,420 +انا انا انا انا انا انا + +486 +00:37:51,420 --> 00:37:55,580 +اناyou go short لما بيحكوا في ال financial market + +487 +00:37:55,580 --> 00:37:58,800 +you go short it means you sell you go long it + +488 +00:37:58,800 --> 00:38:02,700 +means buy افهموا ما دول مصطلحات ال financial + +489 +00:38:02,700 --> 00:38:07,640 +markets it's new for you يعني لو تترجموها ميه + +490 +00:38:07,640 --> 00:38:11,660 +الترجمة long مش هتعرفوها buy و sell مظبوط ولا لأ + +491 +00:38:11,660 --> 00:38:18,700 +long و short okay هلا الفرق بين ال option و ال + +492 +00:38:18,700 --> 00:38:19,060 +future + +493 +00:38:23,570 --> 00:38:29,390 +long buy و short sell it means in long you are + +494 +00:38:29,390 --> 00:38:32,750 +take the delivery take delivery at maturity take + +495 +00:38:32,750 --> 00:38:38,210 +يعني بناخد يعني احنا buy صح ولا لأ لما بناخد we + +496 +00:38:38,210 --> 00:38:43,390 +buy when make delivery يعني بنعطي معناه الكلام we + +497 +00:38:43,390 --> 00:38:49,300 +sell okay بنبيعالفرق بين ال option و ال future + +498 +00:38:49,300 --> 00:38:55,120 +الفرق الأول option is right يعني ممكن و لأ يعني + +499 +00:38:55,120 --> 00:38:58,000 +ممكن نفذ و ممكن ما ننفذ it is right but not + +500 +00:38:58,000 --> 00:39:02,980 +obligation لكن مش شرط لازم ننفذ to buy or sell + +501 +00:39:02,980 --> 00:39:07,790 +option is exerciseonly when it is profitable يعني + +502 +00:39:07,790 --> 00:39:10,990 +بس بننفذ لما يصير في عنا ربح بننفذش مع الكلام we + +503 +00:39:10,990 --> 00:39:13,790 +lose only the premium يعني هنخسر بس ال premium + +504 +00:39:13,790 --> 00:39:17,110 +option must be purchased لازم نشتري ال option + +505 +00:39:17,110 --> 00:39:21,510 +نشتري ال call و بنبيع ال bot the premium is the + +506 +00:39:21,510 --> 00:39:24,870 +price of the option itself ال premium نفسها سعر ال + +507 +00:39:24,870 --> 00:39:29,370 +option لأن احنا فقط بندفع ال premium لكن ال future + +508 +00:39:29,370 --> 00:39:34,010 +contract we have toobliged to make or to take + +509 +00:39:34,010 --> 00:39:38,290 +delivery لازم لازم لازم نروح يا اما ان انا اما + +510 +00:39:38,290 --> 00:39:41,190 +ننفذ او ننفذ يعني so you don't have any option + +511 +00:39:41,190 --> 00:39:45,890 +ماعناش any option so you have to exercise long + +512 +00:39:45,890 --> 00:39:51,450 +position must buy زي ما احنا شرحناها لازم نشتري at + +513 +00:39:51,450 --> 00:39:55,470 +the future prices short position must sell okay + +514 +00:39:56,420 --> 00:39:59,300 +just accept donation احنا ال call option حكينا + +515 +00:39:59,300 --> 00:40:03,040 +فيها buy ال bot option حكينا فيها sell future + +516 +00:40:03,040 --> 00:40:07,000 +contracts are entered into without cost مابتكلفناش + +517 +00:40:07,000 --> 00:40:12,060 +اشي just set the price لكن بال options دفعنا + +518 +00:40:12,060 --> 00:40:16,080 +premium او discount بس ال future you just fix the + +519 +00:40:16,080 --> 00:40:16,400 +price + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw.srt new file mode 100644 index 0000000000000000000000000000000000000000..656515e2d04bf32e964e78b3919ada721bbf036b --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw.srt @@ -0,0 +1,1943 @@ +1 +00:00:21,240 --> 00:00:24,920 +we talk about the bond pricing المرة الأولى حكينا + +2 +00:00:24,920 --> 00:00:29,140 +عن bond pricing يعني كيف يتسعر السندات and how + +3 +00:00:29,140 --> 00:00:33,440 +the United States particularly the Wall Street + +4 +00:00:33,440 --> 00:00:38,120 +Journal how they price the bonds particularly the + +5 +00:00:38,120 --> 00:00:41,510 +treasury notes and treasury bonds today I'm going + +6 +00:00:41,510 --> 00:00:45,170 +to talk in details about the bond markets يعني + +7 +00:00:45,170 --> 00:00:47,650 +اليوم هنحكي بتفاصيل ال bond market أسواق السندات + +8 +00:00:47,650 --> 00:00:50,950 +and to talk about the stock market as well و هنحكي + +9 +00:00:50,950 --> 00:00:54,250 +أيضا عن أسواق الأسهم I think this is very simple + +10 +00:00:54,250 --> 00:01:00,210 +you don't have complicated things in understanding + +11 +00:01:00,210 --> 00:01:03,130 +the bond market يعني مش هيكون عندنا الوضع صعب في + +12 +00:01:03,130 --> 00:01:07,410 +ال bond market so today I'm focusing on the bond + +13 +00:01:07,410 --> 00:01:11,450 +market in details and the stock market in details + +14 +00:01:11,450 --> 00:01:15,430 +fine just to remind you I talked about the main + +15 +00:01:15,430 --> 00:01:18,630 +difference between treasury notes and bonds حكينا + +16 +00:01:18,630 --> 00:01:21,570 +الفرق بين ال treasury notes و ال treasury bonds + +17 +00:01:21,570 --> 00:01:24,710 +الاثنين يتم إصدارهم من قبل ال government من قبل + +18 +00:01:24,710 --> 00:01:29,570 +الحكومة the treasury notes is equal to or less than + +19 +00:01:29,570 --> 00:01:34,210 +10 years however the treasury bonds is greater + +20 +00:01:34,210 --> 00:01:40,350 +than 10 years up to 30 years yesterday I logged in to + +21 +00:01:40,350 --> 00:01:43,630 +the Wall Street Journal and I found some bonds + +22 +00:01:43,630 --> 00:01:49,270 +issued or the maturity dates of some bonds up to + +23 +00:01:49,270 --> 00:01:54,930 +43. The day before it was 42. Today, yesterday I + +24 +00:01:54,930 --> 00:01:58,630 +showed some bonds, the maturity dates of these + +25 +00:01:58,630 --> 00:02:03,250 +bonds up to 43. I think in your free time it is fine to + +26 +00:02:03,250 --> 00:02:09,990 +log in to www.wsj.com in order to gain some + +27 +00:02:09,990 --> 00:02:13,330 +practical experience on how the different market + +28 +00:02:13,330 --> 00:02:16,330 +pricing the bond حتى إن أنتم تشوفوا من ناحية + +29 +00:02:16,330 --> 00:02:19,630 +العملية كيف الأسواق المالية بتعمل تسعير لأسواق + +30 +00:02:19,630 --> 00:02:24,680 +السندات inflation protected treasury bonds these + +31 +00:02:24,680 --> 00:02:28,440 +bonds are issued to fight against inflation + +32 +00:02:28,440 --> 00:02:32,180 +يعني هذه النوعية من السندات يتم إصدارها حتى تواجه + +33 +00:02:32,180 --> 00:02:36,580 +التضخم I don't want to focus on this type of bonds + +34 +00:02:36,580 --> 00:02:39,540 +أنا مش هركز على هذه الأنواع من السندات because this is + +35 +00:02:39,540 --> 00:02:43,380 +issued for a particular purpose مش هركز على هذا + +36 +00:02:43,380 --> 00:02:48,100 +النوع من السندات لأنه هيكون التركيز على treasury + +37 +00:02:48,100 --> 00:02:50,380 +notes and bonds و على ال corporate bonds هذا + +38 +00:02:50,380 --> 00:02:54,480 +التركيز بتاعنا federal agency debts the same thing + +39 +00:02:54,480 --> 00:02:56,660 +I don't want to focus on this مش هركز على + +40 +00:02:56,660 --> 00:03:03,000 +international bonds international bonds هي .. هي + +41 +00:03:03,000 --> 00:03:07,120 +سندات دولية حيث ال international bonds هم سندات + +42 +00:03:07,120 --> 00:03:12,740 +دولية يتم إصدارهم على مستوى دولي so it is marketed + +43 +00:03:12,740 --> 00:03:17,300 +in international markets so any company of the + +44 +00:03:17,300 --> 00:03:20,440 +United States أي شركة خارج الولايات المتحدة + +45 +00:03:20,440 --> 00:03:24,540 +الأمريكية ممكن تشتري هذا السند for instance we + +46 +00:03:24,540 --> 00:03:30,980 +have Yankee bonds and we have the .. the yen euro + +47 +00:03:30,980 --> 00:03:34,640 +bonds these bonds are traded internationally يعني + +48 +00:03:34,640 --> 00:03:39,040 +في مثلا عندنا سندات أصدرها اليابان شركات يابانية + +49 +00:03:39,040 --> 00:03:41,960 +مثلا بالدولار فبتتم التداول فيها بال .. بالسوق + +50 +00:03:41,960 --> 00:03:46,000 +الدولي في شركات أمريكية كمان تقوم بإصدار سندات + +51 +00:03:46,000 --> 00:03:48,590 +خارج الولايات المتحدة الأمريكية وهذا حكينا فيها + +52 +00:03:48,590 --> 00:03:51,390 +اسمها ال euro dollar bonds اللي هو ال euro dollar + +53 +00:03:51,390 --> 00:03:55,150 +bonds هدول بيصير فيهم traded off the United States + +54 +00:03:55,150 --> 00:03:59,270 +و هدول بتسميهم كمان international bonds ففي سندات + +55 +00:03:59,270 --> 00:04:05,450 +يتم إصدارها للتداول في مستوى العالم I talked about + +56 +00:04:05,450 --> 00:04:08,930 +municipal bonds اللي هو سندات البلديات and I + +57 +00:04:08,930 --> 00:04:12,110 +mentioned two types of bonds حكينا على نوعين + +58 +00:04:12,110 --> 00:04:17,820 +من ال bonds the revenue bonds and general + +59 +00:04:17,820 --> 00:04:23,680 +obligation bonds the general obligation bonds as + +60 +00:04:23,680 --> 00:04:29,800 +you see here the + +61 +00:04:29,800 --> 00:04:33,220 +municipal bonds the types of bonds general + +62 +00:04:33,220 --> 00:04:37,960 +obligation bonds okay and this is this general + +63 +00:04:37,960 --> 00:04:42,320 +obligation bonds general obligation bonds, this .. + +64 +00:04:42,320 --> 00:04:44,860 +this bond .. I will go back to the .. to the + +65 +00:04:44,860 --> 00:04:47,540 +previous slides just to focus on the type now + +66 +00:04:47,540 --> 00:04:52,340 +general obligations bonds هاي بتكون التزامات على + +67 +00:04:52,340 --> 00:04:55,720 +البلديات أو ال local governments الحكومة المحلية + +68 +00:04:56,460 --> 00:05:01,320 +and these bonds are paid back by using taxation + +69 +00:05:01,320 --> 00:05:04,660 +يتم تسديدها من خلال ال taxation من خلال الضريبة as + +70 +00:05:04,660 --> 00:05:07,460 +as you see here backed by taxing power of issuer + +71 +00:05:07,460 --> 00:05:12,360 +يعني البلدية نفسها بتسد قيمة السندات هذه من خلال + +72 +00:05:12,360 --> 00:05:17,030 +من خلال من خلال الضريبة Okay the second .. the + +73 +00:05:17,030 --> 00:05:18,930 +second one which is more important than the + +74 +00:05:18,930 --> 00:05:22,750 +previous one الثاني وهو أهم من الأول بيسموها ال + +75 +00:05:22,750 --> 00:05:26,890 +revenue bonds ال revenue bonds هاي سندات إيرادية + +76 +00:05:26,890 --> 00:05:32,610 +موجودين + +77 +00:05:32,610 --> 00:05:39,030 +في page 36 لأ + +78 +00:05:39,030 --> 00:05:41,650 +إننا نحكي في تفاصيل هلأ تفاصيل + +79 +00:05:43,940 --> 00:05:48,820 +I will go back to them هرجعهم okay فال revenue + +80 +00:05:48,820 --> 00:05:55,360 +bonds are backed by projects revenues يعني هي مدعومة + +81 +00:05:55,360 --> 00:05:59,260 +من الإيرادات بتاعة المشروع واللي هنحكي إيش + +82 +00:05:59,260 --> 00:06:02,340 +المشاريع اللي بيقوموا فيها or by the municipal + +83 +00:06:02,340 --> 00:06:06,320 +agency operating the projects هلأ الحكومة بتصدر + +84 +00:06:06,320 --> 00:06:10,040 +نوع من السندات اسمه ال revenue bonds اللي هو + +85 +00:06:10,040 --> 00:06:12,880 +السندات الإيرادية مثلا بيروحوا بيفت بيعملوا مواد + +86 +00:06:12,880 --> 00:06:17,450 +جديدة فجزء من إيرادات الموانق بتروح للبلدية و + +87 +00:06:17,450 --> 00:06:21,850 +البلدية بتروح بت .. بتسد ال .. بتسد ال bonds .. + +88 +00:06:21,850 --> 00:06:26,470 +السندات مثلا هم بيعملوا طرق ال highways ال + +89 +00:06:26,470 --> 00:06:31,010 +highways و ال motorways اللي هو الطرق السريعة فجزء + +90 +00:06:31,010 --> 00:06:33,950 +من إيرادات الطرق السريعة مثلا الحكومة بتاخد ضريبة + +91 +00:06:33,950 --> 00:06:38,020 +على الطرق فجزء من الضريبة هاي بتروح لمين؟ بتروح لل + +92 +00:06:38,020 --> 00:06:42,820 +.. لل municipal للبلديات وبت .. تالي البلديات بي + +93 +00:06:42,820 --> 00:06:48,460 +.. بيسددوا الضريبة .. بيسددوا قيمة السندات كمان + +94 +00:06:48,460 --> 00:06:54,180 +إذا كانت مثلا الحكومة أو البلدية بتعمل مطارات عشان + +95 +00:06:54,180 --> 00:06:57,880 +تخلي الشركات تعمل .. تعمل investment في هذه + +96 +00:06:57,880 --> 00:07:01,580 +المطارات فجزء من إيرادات المطارات بتروح برضه لسداد + +97 +00:07:01,580 --> 00:07:06,030 +ال .. ال municipal أو بيسموها ال revenue bonds فهذا + +98 +00:07:06,030 --> 00:07:10,410 +يعني .. يعني كتمويل ل ال infrastructure البنية + +99 +00:07:10,410 --> 00:07:14,390 +التحتية بتاعتها في الدولة okay بالبلدية بتقوم إصدار سندات + +100 +00:07:14,390 --> 00:07:18,450 +حتى تستطيع تمول هاي المشاريع الكبيرة okay فبنسميها + +101 +00:07:18,450 --> 00:07:25,550 +ال revenue bonds لو رجعنا احنا شوية على ال .. ال + +102 +00:07:25,550 --> 00:07:29,800 +treasury notes and bonds حكينا ال municipal bonds و + +103 +00:07:29,800 --> 00:07:33,340 +the bond markets حكينا احنا بالأول إن في عندنا + +104 +00:07:33,340 --> 00:07:35,640 +municipal bonds و في عندنا corporate bonds و عندنا + +105 +00:07:35,640 --> 00:07:39,480 +الموردجاج just to remind you خليني بس أذكركم ب .. + +106 +00:07:39,480 --> 00:07:42,380 +the big picture of the market bonds خليني أذكركم + +107 +00:07:42,380 --> 00:07:48,240 +بال .. بالأسواق السندات بشكل عام حكينا ال bond + +108 +00:07:48,240 --> 00:07:53,220 +markets okay حكينا in generally we have two types + +109 +00:07:53,220 --> 00:07:58,350 +of bond markets اللي هو governmental bonds و + +110 +00:07:58,350 --> 00:08:02,170 +corporate bonds the + +111 +00:08:02,170 --> 00:08:06,350 +government bonds are issued by the governments or + +112 +00:08:06,350 --> 00:08:09,630 +local governments يعني من ال governments or local + +113 +00:08:09,630 --> 00:08:11,810 +governments ال local governments such as + +114 +00:08:11,810 --> 00:08:16,010 +municipals اللي هو البلديات the government bonds + +115 +00:08:16,010 --> 00:08:23,110 +عندنا اللي هو the treasury notes and treasury + +116 +00:08:23,110 --> 00:08:26,590 +bonds and we have here the municipal + +117 +00:08:29,540 --> 00:08:34,560 +the municipal bonds include two main bonds the + +118 +00:08:34,560 --> 00:08:39,760 +general obligation bonds and + +119 +00:08:39,760 --> 00:08:44,680 +revenue bonds and there is another type of bonds + +120 +00:08:44,680 --> 00:08:47,780 +called the industrial bonds this industrial bonds + +121 +00:08:47,780 --> 00:08:51,800 +is considered as one part of the revenue bonds + +122 +00:08:51,800 --> 00:08:55,300 +يعني هو نوع من أنواع ال revenue bonds اللي هو + +123 +00:08:55,300 --> 00:08:58,360 +industrial bonds industrial bonds اللي هو سندات + +124 +00:08:58,360 --> 00:09:06,120 +صناعية بنسميها industrial bonds يعني + +125 +00:09:06,120 --> 00:09:12,500 +.. يعني مثلا الحكومة بدها تعمل مناطق صناعية فعشان + +126 +00:09:12,500 --> 00:09:17,320 +يتشجع الصناعة في البلد okay فبروح بصدره industrial + +127 +00:09:17,320 --> 00:09:21,420 +bonds طبعا من وين بتصد ال industrial bonds؟ هذا بتصد + +128 +00:09:21,420 --> 00:09:24,500 +من الصناعة اللي هتنشأ في ال .. في هذه المناطق + +129 +00:09:24,500 --> 00:09:28,040 +الصناعية فبيقوموا بيصدوا الإيرادات بتاعتهم في ال + +130 +00:09:28,040 --> 00:09:31,380 +corporate bonds اللي هنأيجي نحكي فيه بقى .. كمان + +131 +00:09:31,380 --> 00:09:39,060 +شوية اللي هو فيه عندنا secured bonds secured okay + +132 +00:09:39,060 --> 00:09:42,440 +secured bond يعني احنا لو نحكي عن ال corporate + +133 +00:09:42,440 --> 00:09:46,320 +bonds اللي هو السندات الشركات في عندنا نوعين النوع + +134 +00:09:46,320 --> 00:09:51,340 +اسمه secured bond اللي هو سندات آمنة اسمها secured + +135 +00:09:51,340 --> 00:09:59,940 +bond وفي عندنا non secured bond سندات غير آمنة و + +136 +00:09:59,940 --> 00:10:03,550 +إيش الفرق بين ال secured و ال non secured؟ ال + +137 +00:10:03,550 --> 00:10:08,030 +secured سندات آمنة يعني انه is the company which + +138 +00:10:08,030 --> 00:10:11,730 +issued this part of bonds has a good historical + +139 +00:10:11,730 --> 00:10:15,650 +profile يعني الشركة اللي أصدرت هذا النوع من السند + +140 +00:10:15,650 --> 00:10:20,290 +الآمن لها good profile يعني سمعتها كويسة و عندها + +141 +00:10:20,290 --> 00:10:23,650 +أرباح منيحة و عندها سمعة طيبة however the non + +142 +00:10:23,650 --> 00:10:28,390 +secured bond السندات الغير أمنة non secured bond + +143 +00:10:28,390 --> 00:10:31,490 +بيكون الشركة اللي أصدرت هذه النوع من السندات شركة + +144 +00:10:31,490 --> 00:10:35,830 +ضعيفة وماعنداش سمعة إمنيها فبيسموها non secured + +145 +00:10:35,830 --> 00:10:36,510 +bond + +146 +00:10:40,070 --> 00:10:46,570 +again للناس اللي يعني إيجوا متأخرين the bond + +147 +00:10:46,570 --> 00:10:50,690 +market is classified into two main parts the first + +148 +00:10:50,690 --> 00:10:52,990 +one the government and the second one is the + +149 +00:10:52,990 --> 00:10:57,950 +corporate the government is divided for three main + +150 +00:10:57,950 --> 00:11:01,350 +types the municipal, the treasury bonds and the + +151 +00:11:01,350 --> 00:11:04,890 +treasury notes the municipal is divided for two + +152 +00:11:04,890 --> 00:11:08,890 +main parts revenue bonds and the general + +153 +00:11:08,890 --> 00:11:17,320 +obligation bonds Okay the corporate bond this + +154 +00:11:17,320 --> 00:11:22,200 +is municipal okay this is treasury bond this is + +155 +00:11:22,200 --> 00:11:26,160 +treasury notes municipal اللي هو البلديات treasury + +156 +00:11:26,160 --> 00:11:30,740 +bonds اللي هو سندات الحكومة هي سندات الحكومة لكن + +157 +00:11:30,740 --> 00:11:34,300 +بنسميها notes okay I explained this before + +158 +00:11:35,630 --> 00:11:38,970 +municipal bonds divided for two main types بتتقسم + +159 +00:11:38,970 --> 00:11:41,930 +لنوعين ال revenue اللي هو الإيرادية والتانية اللي + +160 +00:11:41,930 --> 00:11:44,570 +هو general obligations اللي هي التزامات على + +161 +00:11:44,570 --> 00:11:48,070 +البلدية نفسها ال revenue في نوع واحد من ال revenue + +162 +00:11:48,070 --> 00:11:50,770 +اللي هو بيسميه industrial اللي هو الصناعي اللي هو + +163 +00:11:50,770 --> 00:11:53,950 +سندات صناعية ال corporate bonds اللي هو سندات + +164 +00:11:53,950 --> 00:11:57,010 +الشركات بتصدرها الشركات we have two main types + +165 +00:11:57,010 --> 00:11:59,610 +اللي هو عندنا secured bond وفي عندنا non secured + +166 +00:11:59,610 --> 00:12:05,320 +bond اللي هو سندات أمنة غير أمينة ملاحظة بسيطة في + +167 +00:12:05,320 --> 00:12:11,520 +ال corporate bonds اللي هو سندات الشركات في عندنا + +168 +00:12:11,520 --> 00:12:15,820 +كتير أنواع لكن احنا for the limits of this level + +169 +00:12:15,820 --> 00:12:18,160 +عشان هذا المستوى من الطلاب because this is + +170 +00:12:18,160 --> 00:12:20,600 +introduction to investments لأن هي مقدمة بال + +171 +00:12:20,600 --> 00:12:23,480 +investments I don't want to go in details about + +172 +00:12:23,480 --> 00:12:27,080 +the different types of the bonds يعني أنا مش راح + +173 +00:12:27,080 --> 00:12:32,210 +أروح كتير تفاصيل بال bonds بأنواعه لأنه you are in + +174 +00:12:32,210 --> 00:12:34,510 +the introduction of investment انتوا عندكوا بس + +175 +00:12:34,510 --> 00:12:38,230 +مقدمة الاستثمار يعني لما تقرأوا في كتب أخرى عن ال + +176 +00:12:38,230 --> 00:12:42,310 +bonds you will find for instance junk bonds يعني + +177 +00:12:42,310 --> 00:12:46,230 +هنشوف ال junk bonds فال junk bonds هذا هو نوع من + +178 +00:12:46,230 --> 00:12:50,190 +أنواع ال non secured bond فمش هنحكي فيه لأنه هذا + +179 +00:12:50,190 --> 00:12:54,490 +شوي متقدم في ال investments municipal + +180 +00:13:01,070 --> 00:13:04,110 +لأنه هي من ال local governments بتنشئها، هي + +181 +00:13:04,110 --> 00:13:07,290 +بتنشئها ال local governments ال municipal هي أصلا + +182 +00:13:07,290 --> 00:13:10,350 +بتنشئها الحكومة فعشان هيك احنا قاعدين under the + +183 +00:13:10,350 --> 00:13:13,990 +governments بس issued by the local governments + +184 +00:13:13,990 --> 00:13:14,710 +okay + +185 +00:13:17,490 --> 00:13:20,950 +طيب، so we talk about municipal bonds, we talk + +186 +00:13:20,950 --> 00:13:24,470 +about corporate bonds and this mortgage and + +187 +00:13:24,470 --> 00:13:26,730 +mortgage-backed bonds I don't want to focus on + +188 +00:13:26,730 --> 00:13:29,450 +this because only the United States they issue + +189 +00:13:29,450 --> 00:13:34,500 +this particular bonds and the UK sometimes I talk + +190 +00:13:34,500 --> 00:13:38,340 +about the maturities about the treasury notes حكيت + +191 +00:13:38,340 --> 00:13:42,520 +عنه أصلا and I mention for the par value of the + +192 +00:13:42,520 --> 00:13:46,140 +treasury notes and bonds is one thousand so don't + +193 +00:13:46,140 --> 00:13:50,760 +mix up between the treasury bills and treasury + +194 +00:13:50,760 --> 00:13:54,240 +notes the treasury bills par value is ten thousand + +195 +00:13:54,240 --> 00:13:58,580 +and the par value of the treasury notes is one + +196 +00:13:58,580 --> 00:14:01,960 +thousand Okay بدناش نعمل خلط بين treasury notes و + +197 +00:14:01,960 --> 00:14:06,340 +treasury bills Interest paid semi-annually حكينا + +198 +00:14:06,340 --> 00:14:10,920 +أنه بتدفع نصف سنوية وورجيناكوا مثلا المرة الفاتة + +199 +00:14:10,920 --> 00:14:14,900 +how we calculate this you just divide C by 2 نقسم + +200 +00:14:14,900 --> 00:14:17,360 +ال coupon rates على اتنين بتطلع مننا ال semi + +201 +00:14:17,360 --> 00:14:20,920 +-annual Quarters percentage of par وورجيناكوا كيف + +202 +00:14:20,920 --> 00:14:24,880 +how we pricing them كيف نعمل تسعير and how we + +203 +00:14:24,880 --> 00:14:30,710 +drive the pricing system okay in your exam في + +204 +00:14:30,710 --> 00:14:35,870 +الامتحان بتاعكم حاطيكم table هذا ال table جاي من ال + +205 +00:14:35,870 --> 00:14:40,690 +.. جاي من ال .. ال wsj.com بدي أجيبه من ال Wall + +206 +00:14:40,690 --> 00:14:44,370 +Street Journal و أقولكم please convert this table + +207 +00:14:44,370 --> 00:14:47,250 +into the pricing system حاولوا ليها الأسعار ال + +208 +00:14:47,250 --> 00:14:51,350 +pricing system يعني كلامي واضح بجيبكم table based + +209 +00:14:51,350 --> 00:14:54,650 +on the percentage as .. as this as in the + +210 +00:14:54,650 --> 00:14:57,770 +percentage of .. of the par value then convert it + +211 +00:14:57,770 --> 00:15:00,990 +into the pricing system and I showed you how to do + +212 +00:15:00,990 --> 00:15:05,680 +this و أرجيتكم المرة الفاتتة how we do this Okay if + +213 +00:15:05,680 --> 00:15:09,100 +you don't understand go back to the videos okay + +214 +00:15:09,100 --> 00:15:20,540 +and you will have the calculations okay + +215 +00:15:20,540 --> 00:15:26,300 +the ask yield if you want to the ask yield is + +216 +00:15:26,300 --> 00:15:31,880 +equal the coupon rates you can write down the + +217 +00:15:31,880 --> 00:15:40,380 +equation for ask yield ask yield is equal the + +218 +00:15:40,380 --> 00:15:50,540 +coupon divided by the ask price ال coupon اختيه ال + +219 +00:15:50,540 --> 00:15:56,080 +coupon من يومين احنا بنحكي في ال coupon الفائدة و + +220 +00:15:56,080 --> 00:15:59,420 +ال ask price اللي هو سعر الشراء for the investors + +221 +00:15:59,420 --> 00:16:04,040 +that's it Okay رجاء ال .. ال .. الاشي اللي بتاخدوه + +222 +00:16:04,040 --> 00:16:07,600 +يعني رجعوله لأنه خلاص أنا بحكيت ال ask and already + +223 +00:16:07,600 --> 00:16:10,220 +you know what it means ask و لما حكيت ال coupon I + +224 +00:16:10,220 --> 00:16:13,560 +don't need to go back on .. on .. ال coupon معروف + +225 +00:16:13,560 --> 00:16:18,080 +ال coupon okay و + +226 +00:16:18,080 --> 00:16:21,380 +أرجعتكم كيف تعمل login لهم okay هلأ المطلوب منكم + +227 +00:16:21,380 --> 00:16:24,360 +أنه to convert this table into the pricing system + +228 +00:16:24,360 --> 00:16:27,480 +that's it مطلوب منكم تعملوا ال pricing system + +229 +00:16:31,830 --> 00:16:35,590 +Okay so the bond markets as as I told you for the + +230 +00:16:35,590 --> 00:16:38,450 +inflation protected federal agency bonds just only + +231 +00:16:38,450 --> 00:16:41,490 +the international bonds we are talking about + +232 +00:16:41,490 --> 00:16:47,850 +listen here we have in the international bonds أنا + +233 +00:16:47,850 --> 00:16:51,490 +حكيت قبل شوية بال international bonds حكيت عن ال + +234 +00:16:51,490 --> 00:16:56,790 +euro bonds و ال yankee bonds ال euro bonds is bond + +235 +00:16:56,790 --> 00:17:04,070 +issued of the united states يعني هي سندات تصدر خارج + +236 +00:17:04,070 --> 00:17:06,990 +المولايات المتحدة الأمريكية in the dollar amount + +237 +00:17:06,990 --> 00:17:12,330 +بقيمة الدولار and .. and I explain why some + +238 +00:17:12,330 --> 00:17:18,410 +institutions issued bonds or dollar bonds of the + +239 +00:17:18,410 --> 00:17:21,410 +United States لأنه ت escape .. ت escape from the + +240 +00:17:21,410 --> 00:17:24,170 +regulations of the Federal Reserve Bank يعني عشان + +241 +00:17:24,170 --> 00:17:27,650 +يخرجوا من سيطرة ال .. البنك الفيدرالي الأمريكي و + +242 +00:17:27,650 --> 00:17:31,010 +بتكون زي ما اتفضلتها انه ال .. ال .. الإيراد او ال + +243 +00:17:31,010 --> 00:17:34,010 +return عالي كتير في مقارنة مع inside the united + +244 +00:17:34,010 --> 00:17:38,050 +states ال yankee bonds which is the opposite of + +245 +00:17:38,050 --> 00:17:42,050 +euro bonds عكسه تمام it means non united states + +246 +00:17:42,050 --> 00:17:46,070 +bonds in the united states تبقى is non united + +247 +00:17:46,070 --> 00:17:51,570 +states companies in the united states issued dollar + +248 +00:17:51,570 --> 00:17:56,430 +bonds يعني بتكون شركات ليست أمريكية يعني ممكن + +249 +00:17:56,430 --> 00:17:58,790 +شركات صينية تكون داخل الولايات المتحدة الأمريكية + +250 +00:17:58,790 --> 00:18:03,130 +تصدر bond بالدولار فهي بيسميها ايش؟ بيسميها Yankee + +251 +00:18:03,130 --> 00:18:07,730 +bonds طبعا Yankee هي .. is a terminology used + +252 +00:18:07,730 --> 00:18:11,270 +by the .. by the financial market هي عبارة عن + +253 +00:18:11,270 --> 00:18:17,570 +مصطلح جاي .. هو تقريبا جاي من هنا جاي أنه أي شركة + +254 +00:18:17,570 --> 00:18:22,150 +.. بنعطيكوا مثال مثلا .. مثلا نحكي شركة rem عارفين + +255 +00:18:22,150 --> 00:18:28,230 +شركة rem؟ rim .. rim .. يضلوا rim .. okay شركة rim + +256 +00:18:28,230 --> 00:18:30,550 +producing the blackberry + +257 +00:18:33,220 --> 00:18:38,080 +Rim is a company which is non-United States + +258 +00:18:38,080 --> 00:18:43,180 +company if Rim issued bonds inside the United States + +259 +00:18:43,180 --> 00:18:46,340 +this bond is considered as a Yankee bond يعني إذا + +260 +00:18:46,340 --> 00:18:50,320 +كانت ريم أصدرت سند داخل الولايات المتحدة الأمريكية + +261 +00:18:50,320 --> 00:18:55,980 +بيسمياه Yankee bond. Okay, another example, if you + +262 +00:18:55,980 --> 00:19:01,760 +talk about Nestle. عارفين شركة Nestle؟ Okay, هاي إيش + +263 +00:19:01,760 --> 00:19:05,600 +أصلها Nestle؟ طبعا الملكية تبعتها اتغيرت مرة + +264 +00:19:05,600 --> 00:19:11,720 +فرنسية .. أخر إشي كانت الملكية تبعتها و if .. if + +265 +00:19:11,720 --> 00:19:15,080 +this company إذا هذه الشركة أصدرت bond inside the + +266 +00:19:15,080 --> 00:19:19,540 +United States هذا ال bond بنسميه Yankee bond. فواضح + +267 +00:19:19,540 --> 00:19:22,360 +انكم what it means Yankee bond. Okay. + +268 +00:19:24,540 --> 00:19:30,380 +And I talk about the municipal bonds, the main + +269 +00:19:30,380 --> 00:19:35,120 +characteristics of the municipal bonds. واحدة من + +270 +00:19:35,120 --> 00:19:39,620 +الخصائص سبعة ال municipal bonds is tax-exempted. + +271 +00:19:39,620 --> 00:19:44,820 +What it means tax-exempted? It means أن السند اللي + +272 +00:19:44,820 --> 00:19:48,540 +بتصدره البلدية هو خالي من الضريبة أو معفي من + +273 +00:19:48,540 --> 00:19:52,950 +الضريبة. Is tax-exempted. خالي من الدريبة. So the + +274 +00:19:52,950 --> 00:19:58,150 +investors are comparing between the bond with a + +275 +00:19:58,150 --> 00:20:02,050 +tax and the bond is tax-exempted. يعني المستثمرين + +276 +00:20:02,050 --> 00:20:05,950 +يقارنوا بين نوعين من السندات، السند اللي عليه ضريبة + +277 +00:20:05,950 --> 00:20:08,750 +والسند اللي معفي من الضريبة. يعني أي investors بدهم + +278 +00:20:08,750 --> 00:20:12,550 +يعمل قرار استثمار بيقارنه بين two different types + +279 +00:20:12,550 --> 00:20:16,250 +of bonds. بيقارنه نوعين من ال bonds، السند اللي عليه + +280 +00:20:16,250 --> 00:20:18,730 +ضريبة و السند اللي معفي من الضريبة. How they do + +281 +00:20:18,730 --> 00:20:21,610 +this؟ كيف بيعملوا كلام هذا؟ I will show you how they + +282 +00:20:21,610 --> 00:20:24,830 +do this. كيف هم بيعملوا conversion between the + +283 +00:20:24,830 --> 00:20:28,350 +taxable bonds and non-taxable bonds or tax + +284 +00:20:28,350 --> 00:20:33,180 +exempted bonds. Okay, and this is a question in your + +285 +00:20:33,180 --> 00:20:36,320 +exam. و هذا كمان سؤال هجيبكوا في الامتحان أنه how + +286 +00:20:36,320 --> 00:20:39,160 +investors compare between the taxable bonds and + +287 +00:20:39,160 --> 00:20:44,860 +the tax-exempted bonds. I will show you how. يعني + +288 +00:20:44,860 --> 00:20:50,520 +كيف المستثمرين بيفرقوا أو بيتخذوا قرار استثمار + +289 +00:20:50,520 --> 00:20:56,900 +بناء على الدريبة. فهم بيقارنوا بين إذا أنا مستثمرو + +290 +00:20:56,900 --> 00:21:01,420 +أمامي two bonds. أمامي سندين، سند عليه ضريبة وسند ما + +291 +00:21:01,420 --> 00:21:05,980 +فيه من الضريبة. أنه أفضل أستثمر هذا ولا هذا؟ So + +292 +00:21:05,980 --> 00:21:09,480 +we cannot say yes or no unless we do some + +293 +00:21:09,480 --> 00:21:13,880 +calculations. يعني مابنقدرش نقول yes or no بدون ما + +294 +00:21:13,880 --> 00:21:16,660 +نعمل some calculations. I will show you how we can + +295 +00:21:16,660 --> 00:21:21,040 +do this. We + +296 +00:21:21,040 --> 00:21:28,070 +cannot say that she said .. she said the one with + +297 +00:21:28,070 --> 00:21:33,690 +tax-exempted is more preferable than the others. We + +298 +00:21:33,690 --> 00:21:38,270 +cannot say this. So we compare between the two + +299 +00:21:38,270 --> 00:21:42,670 +bonds with taxable and with tax-exempted. هنقارن + +300 +00:21:42,670 --> 00:21:47,350 +بين الاتنين. How we can do this? I will show you how + +301 +00:21:47,350 --> 00:21:50,830 +we can do this. هنشوفكم .. هنشوف كيف نعمل الكلام + +302 +00:21:50,830 --> 00:21:57,230 +هذا. طيب، هلو لو احنا اعطينا رمز لل taxable bonds .. + +303 +00:21:57,230 --> 00:22:03,310 +non-taxable bonds RM + +304 +00:22:03,310 --> 00:22:06,930 +RM + +305 +00:22:06,930 --> 00:22:11,470 +is stand for municipal bonds. يعني العائد على السند + +306 +00:22:11,470 --> 00:22:15,630 +اللي بتصدره البلدية. And as we agree واتفقنا مع بعض + +307 +00:22:15,630 --> 00:22:19,570 +the municipal bond is tax-exempted. يعني اتفقنا مع + +308 +00:22:19,570 --> 00:22:22,770 +بعض أنه السندات اللي بتصدرها البلدية ما فيها من + +309 +00:22:22,770 --> 00:22:26,950 +الدريبة. So the return of M is to stand for the + +310 +00:22:26,950 --> 00:22:32,250 +municipal bonds if tax-exempted. If this equal X + +311 +00:22:32,250 --> 00:22:35,650 +for instance, X is a number or the rate of return + +312 +00:22:35,650 --> 00:22:43,080 +and R is the taxable bonds. So again, RM is tax-free + +313 +00:22:43,080 --> 00:22:48,220 +يعني ماعلوش ضريبة و R هو عليه ضريبة. And we compare + +314 +00:22:48,220 --> 00:22:54,760 +between two of them. But this is because this has a + +315 +00:22:54,760 --> 00:22:58,120 +taxation. So we have to pay tax. So we deduct tax + +316 +00:22:58,120 --> 00:23:02,020 +from this. لازم نختم منه ضريبة صح؟ So deducted tax + +317 +00:23:02,020 --> 00:23:08,930 +is one minus T. One minus T. T is stand for taxation. + +318 +00:23:08,930 --> 00:23:20,710 +يعني T ترمز إلى الدريبة. T if R. الدريبة T stands for + +319 +00:23:20,710 --> 00:23:26,890 +taxation. T tax. R is the rate of return of the + +320 +00:23:26,890 --> 00:23:32,710 +taxable bonds. Okay, R is the taxable bonds. السند + +321 +00:23:32,710 --> 00:23:36,050 +اللي عليه ضريبة. So we are comparing between this + +322 +00:23:36,050 --> 00:23:40,310 +and this. We are in other words احنا بنقارن بالسند + +323 +00:23:40,310 --> 00:23:42,550 +اللي عليه ضريبة في عائد السند اللي عليه ضريبة + +324 +00:23:42,550 --> 00:23:49,710 +وعائد السند اللي معفي من الضريبة. Okay. So if this + +325 +00:23:49,710 --> 00:23:58,910 +equal Y. It means if R is greater than RM. إذا كان + +326 +00:23:58,910 --> 00:24:02,650 +العائد بتاع R، طبعا الـR هي إيش؟ العلي ضريبة، + +327 +00:24:02,650 --> 00:24:10,250 +العلي ضريبة is greater than RM, so we prefer R. It + +328 +00:24:10,250 --> 00:24:17,230 +means we are not always keep our eyes in the + +329 +00:24:17,230 --> 00:24:20,670 +municipal bonds. يعني مش دايما احنا we select + +330 +00:24:20,670 --> 00:24:24,310 +municipal bonds because it depends on the R after + +331 +00:24:24,310 --> 00:24:29,020 +tax. لأنه بنحسب ال R after tax. يعني قداش بعد الضريبة + +332 +00:24:29,020 --> 00:24:32,240 +and then after that we compare between them. If R + +333 +00:24:32,240 --> 00:24:37,440 +is greater than RM, so we go for R. Otherwise .. + +334 +00:24:37,440 --> 00:24:41,860 +otherwise. يعني إذا ماكانش الكلام هذا we go for RM. + +335 +00:24:41,860 --> 00:24:47,320 +يعني إذا كان العكس is the opposite. If RM is + +336 +00:24:47,320 --> 00:24:53,580 +greater than R, we prefer RM. This is very simple + +337 +00:24:56,470 --> 00:25:00,410 +which one. Okay. + +338 +00:25:00,410 --> 00:25:05,930 +هلأ احنا هال R M ماعليهاش ضريبة صح؟ و ال R اللي هي + +339 +00:25:05,930 --> 00:25:08,270 +اللي عليها ضريبة هيخلصنا منها الضريبة one minus + +340 +00:25:08,270 --> 00:25:12,570 +T. إذا كان الجواب، let's say إذا كان + +341 +00:25:12,570 --> 00:25:17,710 +الجواب عندنا هان كان هان هان مثلا six percent. Okay. + +342 +00:25:17,710 --> 00:25:23,790 +و هان كان after tax is seven percent. So in this + +343 +00:25:23,790 --> 00:25:30,410 +case, R is greater than RM. So we select R. نختار ال + +344 +00:25:30,410 --> 00:25:34,490 +R. Otherwise, if this is wrong. Otherwise إذا كان + +345 +00:25:34,490 --> 00:25:41,930 +العكس. So RM is greater than R. نختار ال R. نختار ال + +346 +00:25:41,930 --> 00:25:48,610 +R. نختار + +347 +00:25:48,610 --> 00:25:50,630 +ال R. نختار ال R. نختار ال R. نختار ال R. نختار ال R. + +348 +00:25:50,630 --> 00:25:50,990 +نختار ال R. نختار ال R. نختار ال R. نختار ال R. نختار + +349 +00:25:50,990 --> 00:25:51,030 +ال R. نختار ال R. نختار ال R. نختار ال R. نختار ال R. + +350 +00:25:51,030 --> 00:25:54,990 +نختار ال R. نختار ال R. نختار ال R. نختار. Let this is + +351 +00:25:54,990 --> 00:25:58,430 +the. Let T equal the investor marginal tax. So this is + +352 +00:25:58,430 --> 00:26:04,010 +T and I explain tax. Okay. Let R equal the before + +353 +00:26:04,010 --> 00:26:07,870 +tax return on the taxable bond. اللي هو ال R شايفين + +354 +00:26:07,870 --> 00:26:11,030 +ال R. This is before tax. لما احنا بنضرب one minus T + +355 +00:26:11,030 --> 00:26:16,150 +بيصير after tax. And RM اللي احنا شرحناها ال RM + +356 +00:26:16,150 --> 00:26:20,390 +شفتوها denote the municipal bonds. اللي هي السند + +357 +00:26:20,390 --> 00:26:26,450 +بتاع البلدية. وحكينا ال municipal bonds هو is tax + +358 +00:26:26,450 --> 00:26:32,780 +exempted. هو مافيه من الضريبة. Why is tax-exempted to + +359 +00:26:32,780 --> 00:26:36,900 +encourage investors to hold this bond؟ ليش البلدية + +360 +00:26:36,900 --> 00:26:40,440 +بتاع فيه من الضريبة عشان تشجع ال investors أنه + +361 +00:26:40,440 --> 00:26:44,560 +تحمل هذا النوع من السندات. طبعا نفس ال calculation + +362 +00:26:44,560 --> 00:26:51,590 +if R (1-T) greater than RM then the taxable bond gives + +363 +00:26:51,590 --> 00:26:54,870 +a higher rate of return. Otherwise, the municipal + +364 +00:26:54,870 --> 00:26:59,590 +bond is preferred. زي ما أنا حكيته إذا كان R (1-T) + +365 +00:26:59,590 --> 00:27:03,310 +اللي شايفينها is greater than RM. So in this case + +366 +00:27:03,310 --> 00:27:08,970 +we prefer the taxable bonds. Otherwise, the tax + +367 +00:27:08,970 --> 00:27:13,910 +exempted bond is preferable. Okay, how we calculate + +368 +00:27:13,910 --> 00:27:21,410 +the كيف ممكن نحسب إذا كان عندي أنا سند one percent + +369 +00:27:21,410 --> 00:27:24,390 +إذا كان عندي one percent سند زي ما انتوا شايفين + +370 +00:27:24,390 --> 00:27:32,590 +هان سند one percent. شايفين هذا ال one percent كيف + +371 +00:27:32,590 --> 00:27:39,070 +بدنا نعرف المقابله من السندات اللي عليها ضريبة. سند + +372 +00:27:39,070 --> 00:27:45,560 +يعني مثلا عندي سند مافيه من الضريبة بتعرف مقابل سند + +373 +00:27:45,560 --> 00:27:47,900 +عليه ضريبة، كده لازم يتساوي مع بعض، فبتسمي + +374 +00:27:47,900 --> 00:27:53,660 +equivalent. يعني equivalent tax yield أنه متى ال .. + +375 +00:27:53,660 --> 00:27:57,840 +ال .. ال .. ال .. ال .. ال two interest rates are + +376 +00:27:57,840 --> 00:28:02,220 +equal متى بيكونوا الثانية بتساوي مع بعض، لو كان + +377 +00:28:02,220 --> 00:28:05,680 +عندي واحد في المية، واحد في المية tax exempted، + +378 +00:28:05,680 --> 00:28:13,130 +ماعليهوش ضريبة equivalent yield هي موجودة هي the + +379 +00:28:13,130 --> 00:28:17,150 +equivalent taxable yield ايش معناه when احنا we + +380 +00:28:17,150 --> 00:28:21,030 +are in difference يطلعوا هنا يطلعوا على ال + +381 +00:28:21,030 --> 00:28:24,850 +equation هادى يطلعوا كلكوا على ال equation هلا ال + +382 +00:28:24,850 --> 00:28:28,670 +equation هنا اللي هو R after tax إذا احنا بنصلحها + +383 +00:28:28,670 --> 00:28:33,990 +هي one minus T okay is greater than RM and RM is + +384 +00:28:33,990 --> 00:28:40,280 +greater than R so my question is when R 1 minus T + +385 +00:28:40,280 --> 00:28:48,080 +is equal RM R 1 minus T is equal R هذا لما يكونوا + +386 +00:28:48,080 --> 00:28:52,760 +متساويتين سوين RM لما يكونوا متساويتين so the + +387 +00:28:52,760 --> 00:28:55,440 +investors are in difference ايش معناه in + +388 +00:28:55,440 --> 00:28:58,440 +difference يعني سواء أخدوا هذا ولا أخدوا هذا نفس + +389 +00:28:58,440 --> 00:29:06,520 +الشيء نفس الشيء okay نريد أن نعرف R1-T وهذا R بعد + +390 +00:29:06,520 --> 00:29:10,160 +الضريبة للمعادلين المتجارين وهذا تجارب ممكن تجارب + +391 +00:29:10,160 --> 00:29:13,240 +تجارب تجارب تجارب + +392 +00:29:13,240 --> 00:29:13,780 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +393 +00:29:13,780 --> 00:29:14,100 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +394 +00:29:14,100 --> 00:29:14,600 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +395 +00:29:14,600 --> 00:29:16,240 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +396 +00:29:16,240 --> 00:29:17,780 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +397 +00:29:17,780 --> 00:29:23,780 +تجارب تجارب تج + +398 +00:29:24,310 --> 00:29:27,630 +interest or these yields one two three four + +399 +00:29:27,630 --> 00:29:31,050 +percent for the tax exempted هدول tax exempted we + +400 +00:29:31,050 --> 00:29:35,410 +want to know if you just hide all of these we want + +401 +00:29:35,410 --> 00:29:39,810 +to know what is the tax the equivalent rate for + +402 +00:29:39,810 --> 00:29:45,750 +the taxable one يعني بتشوف قد ايش العائد على ال + +403 +00:29:45,750 --> 00:29:48,890 +taxable على السند اللي عليه ضريبة قد ايش .. وين + +404 +00:29:48,890 --> 00:29:52,430 +بتساوي أنا بأعطيكوا الضريبة زي ما أنتم شايفين + +405 +00:29:52,430 --> 00:29:57,410 +طلعوها ال marginal tax rate مرة أعطيناها 20% مرة + +406 +00:29:57,410 --> 00:30:03,090 +30% مرة 40 مرة 50 لأن مرات بتتغير الضريبة okay how + +407 +00:30:03,090 --> 00:30:08,370 +we calculate this you just follow the equation so + +408 +00:30:08,370 --> 00:30:14,730 +RM divided by 1 minus T يعني 1% تقسيم 1 minus T + +409 +00:30:14,730 --> 00:30:20,290 +اللي هو 20% خلينا إذا أنتم حابين تتأكدوا إنه هاي + +410 +00:30:20,290 --> 00:30:23,830 +ال one point twenty five اللي شايفينها هنا how we + +411 +00:30:23,830 --> 00:30:29,570 +get this one percent اللي هي ال tax exempted تقسيم + +412 +00:30:29,570 --> 00:30:34,530 +واحد minus اللي هي العشرين في المية twenty percent + +413 +00:30:35,410 --> 00:30:39,170 +بتطلع هذه how we can do the next البعديها كيف + +414 +00:30:39,170 --> 00:30:43,250 +هنعملها لل the same الواحد في المية تقسيم واحد + +415 +00:30:43,250 --> 00:30:48,050 +minus 30 yes 30 percent and the rest و بتعمل + +416 +00:30:48,050 --> 00:30:52,430 +الكلام هذا كله طيب معناه الكلام بعد ما نخلص ال + +417 +00:30:52,430 --> 00:30:55,810 +table بعد + +418 +00:30:55,810 --> 00:31:00,890 +ما نخلص ال table it means انتبهوا هنا one point + +419 +00:31:00,890 --> 00:31:05,290 +twenty five percent taxable bond is equal one + +420 +00:31:05,290 --> 00:31:11,790 +percent tax exempted bond يعني لو احنا أخدنا سند + +421 +00:31:11,790 --> 00:31:16,010 +عليه ضريبة الواحد فاصلة اتنين فاصلة خمسة after tax + +422 +00:31:16,010 --> 00:31:22,930 +هيساوي واحد في المية على سند معفي من الضريبة لو احنا + +423 +00:31:22,930 --> 00:31:28,670 +أخدنا هنا كمان لو أخدنا مثلا هنا لعند 4% لعند 40% + +424 +00:31:28,670 --> 00:31:34,890 +الضريبة سند بيعطيني سند عليه ضريبة 6.67% هو نفسه + +425 +00:31:34,890 --> 00:31:40,530 +هيساوي 4% إذا كان معفي من الضريبة لو أخدنا ال 10% + +426 +00:31:40,530 --> 00:31:46,550 +هذا المثال this bond is taxable bond هذا عليه + +427 +00:31:46,550 --> 00:31:51,670 +ضريبة is equal 5% if it is tax exempted يعني 5% + +428 +00:31:51,670 --> 00:31:54,830 +بتساوي 10% في حالة إعفاء الضريبة + +429 +00:32:00,290 --> 00:32:08,950 +Okay؟ كيف؟ where أي واحدة؟ هذه؟ نفس الطريقة هذه + +430 +00:32:08,950 --> 00:32:12,510 +نفسي أنا بس وريتك واحدة تانية مش هوريك الكل + +431 +00:32:12,510 --> 00:32:15,850 +طلعنا + +432 +00:32:15,850 --> 00:32:23,510 +ال equivalence طلعنا هذه ال T طلعنا أنه متى هذا + +433 +00:32:23,510 --> 00:32:27,170 +بيساوي هذا ايش ال rates بيكون مثلا أنا ال R مش + +434 +00:32:27,170 --> 00:32:33,130 +عارفها I don't know this R I know RM I know T so + +435 +00:32:33,130 --> 00:32:37,930 +only things I need this so in this case R is equal + +436 +00:32:37,930 --> 00:32:47,570 +من المعادلة RM divided by 1 minus T شو؟ + +437 +00:32:49,920 --> 00:32:53,580 +الواحد في اكتشاف اه هي tax exempted شايفها هي tax + +438 +00:32:53,580 --> 00:32:58,260 +exempted نرجع للمعادلة يا بنات بنات هذه very + +439 +00:32:58,260 --> 00:33:04,280 +simple mathematics mathematics بتاعة very simple + +440 +00:33:04,280 --> 00:33:08,980 +تبقوا علينا شوفوا + +441 +00:33:08,980 --> 00:33:16,080 +رياضيا هلأ كان عندي R one minus T should equal RM + +442 +00:33:16,080 --> 00:33:23,920 +مظبوط؟ زي ما علمونا في الرياضيات if I want R so R + +443 +00:33:23,920 --> 00:33:28,600 +is equal RM و هذه بتروح تحت هذه صح؟ one minus T + +444 +00:33:28,600 --> 00:33:35,160 +فأنا كأني بسأل what is the rate of taxable bond if + +445 +00:33:36,320 --> 00:33:41,460 +R is R after tax equal RM ففي الحالة هذه أنا مش + +446 +00:33:41,460 --> 00:33:45,640 +عارف ال R ف RM divided by 1 minus T فهذه + +447 +00:33:45,640 --> 00:33:48,020 +Mathematics أنا كنت أفكر أن أنت you know what it + +448 +00:33:48,020 --> 00:33:51,000 +means mathematically يعني أنا بفكر أن أنت بتعرف + +449 +00:33:51,000 --> 00:33:56,020 +Mathematically فأنا + +450 +00:33:56,020 --> 00:34:05,500 +مش عارف هذه I don't know this بالظبط كده this one + +451 +00:34:06,800 --> 00:34:10,740 +هيبقى أنا .. أنا هذا ال .. ال table هذا مش موجود + +452 +00:34:10,740 --> 00:34:15,440 +أصلًا and I just give you the tax exempted و بعطيك + +453 +00:34:15,440 --> 00:34:19,640 +الضريبة and I'm asking you what is the equivalent + +454 +00:34:19,640 --> 00:34:24,280 +rate of return if you know this بال equivalent + +455 +00:34:24,280 --> 00:34:30,260 +rate of return يعني متى ال R هتساوي ال RM you + +456 +00:34:30,260 --> 00:34:35,540 +understand؟ بس ال RM هي النمرة اللي بيبقى بالعالم + +457 +00:34:44,700 --> 00:34:50,480 +خلينا .. خلينا ال investors تبقوا علينا ال + +458 +00:34:50,480 --> 00:34:56,300 +investors بالأخير معنيين في العائد عندهم أنت عندك + +459 +00:34:56,300 --> 00:35:01,670 +سندين سند عليه ضريبة و سند ما عليهش ضريبة مش دائما + +460 +00:35:01,670 --> 00:35:04,850 +السند اللي ما عليهوش ضريبة is preferable مش .. مش + +461 +00:35:04,850 --> 00:35:08,610 +دائما بنات مش دائما السند اللي عليه اللي معاه فيه + +462 +00:35:08,610 --> 00:35:12,290 +مرة ضريبة هو كويس فال investors أول ما بيطلع لازم + +463 +00:35:12,290 --> 00:35:16,370 +يحسب ال return من هذا و ال return من هذا و بيعمل + +464 +00:35:16,370 --> 00:35:19,790 +comparison between them إذا كان ال return من ال + +465 +00:35:19,790 --> 00:35:23,150 +taxable أفضل فأنا بروح على ال taxable if the + +466 +00:35:23,150 --> 00:35:27,010 +return of the exempted so I prefer the exempted + +467 +00:35:27,010 --> 00:35:30,680 +لأن ال .. the .. we assume that the investors are + +468 +00:35:30,680 --> 00:35:34,820 +rational يعني بالعربي يا بنات لو أنتم روحتوا على + +469 +00:35:34,820 --> 00:35:40,620 +البلد بدكم تشتريوا a t-shirt ف how much this one + +470 +00:35:40,620 --> 00:35:43,740 +this is twenty شيكل and another one say this is + +471 +00:35:43,740 --> 00:35:47,600 +twenty five شيكل so which you prefer يعني الأول + +472 +00:35:47,600 --> 00:35:49,760 +حكوا لكوا عشرين شيكل و الثاني حكوا لكوا خمسة و عشرين + +473 +00:35:49,760 --> 00:35:54,640 +شيكل عاملين بتروحوا للأبو العشرين طيب if you have + +474 +00:35:54,640 --> 00:35:58,900 +two projects لو كان عندي مشروعين مشروع بيعطيني 10% + +475 +00:35:58,900 --> 00:36:04,520 +ومشروع بيعطيني 12% أي مشروع أروح؟ أبو 12% and this + +476 +00:36:04,520 --> 00:36:08,840 +is the same لو كان عندي سندين واحد بيعطيني إثنا عشر + +477 +00:36:08,840 --> 00:36:10,660 +في المية وواحد عشر في المية بروح أبو إثنا عشر في + +478 +00:36:10,660 --> 00:36:14,180 +المية but the problem is we have taxable and we + +479 +00:36:14,180 --> 00:36:18,940 +have non-taxable so we just do the taxable one + +480 +00:36:18,940 --> 00:36:21,760 +calculate the taxation then what is the equivalent + +481 +00:36:21,760 --> 00:36:27,220 +rate of return just to conclude احنا حكينا على ال + +482 +00:36:27,220 --> 00:36:30,220 +bond market و حكينا على ال governments ال + +483 +00:36:30,220 --> 00:36:32,860 +municipal bonds و حكينا على ال treasury notes و + +484 +00:36:32,860 --> 00:36:37,580 +treasury bills and that's it in the in the next in + +485 +00:36:37,580 --> 00:36:39,460 +the next meeting I will focus on the corporate + +486 +00:36:39,460 --> 00:36:40,900 +bonds and stocks diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw_raw.json b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..2cb2e384b8f9b97870fa8de190fe37b3410339e5 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 3956, "start": 21.24, "end": 39.56, "text": "we talk about the bond pricing المرة الأولى حكينا عن bond pricing يعني كيف يتساعر السندات and how the united states particularly the Wall Street Journal how they price the bonds particularly the treasury notes and treasury bonds", "tokens": [826, 751, 466, 264, 6086, 17621, 9673, 25720, 16247, 12610, 7578, 11331, 4117, 1829, 8315, 18871, 6086, 17621, 37495, 22653, 9122, 33911, 7251, 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56.59, "end": 56.97, "word": " have", "probability": 0.96728515625}, {"start": 56.97, "end": 57.99, "word": " complicated", "probability": 0.869140625}, {"start": 57.99, "end": 58.59, "word": " things", "probability": 0.8759765625}, {"start": 58.59, "end": 58.87, "word": " in", "probability": 0.90869140625}, {"start": 58.87, "end": 60.21, "word": " understanding", "probability": 0.75048828125}, {"start": 60.21, "end": 60.57, "word": " the", "probability": 0.8984375}, {"start": 60.57, "end": 60.81, "word": " bond", "probability": 0.95361328125}, {"start": 60.81, "end": 61.19, "word": " market", "probability": 0.8935546875}, {"start": 61.19, "end": 61.47, "word": " يعني", "probability": 0.965576171875}, {"start": 61.47, "end": 61.59, "word": " مش", "probability": 0.96484375}, {"start": 61.59, "end": 61.87, "word": " هيكون", "probability": 0.881103515625}, {"start": 61.87, "end": 62.07, "word": " عندنا", "probability": 0.90673828125}, {"start": 62.07, "end": 62.33, "word": " الوضع", "probability": 0.9073486328125}, {"start": 62.33, "end": 62.69, "word": " صعب", "probability": 0.9918619791666666}, {"start": 62.69, "end": 63.13, "word": " في", "probability": 0.9375}, {"start": 63.13, "end": 63.19, "word": " ال", "probability": 0.93505859375}, {"start": 63.19, "end": 63.33, "word": " bond", "probability": 0.9521484375}, {"start": 63.33, "end": 63.59, "word": " market", "probability": 0.935546875}, {"start": 63.59, "end": 63.81, "word": " so", "probability": 0.7744140625}, {"start": 63.81, "end": 64.29, "word": " today", "probability": 0.80126953125}, {"start": 64.29, "end": 64.63, "word": " I'm", "probability": 0.975830078125}, {"start": 64.63, "end": 65.05, "word": " focusing", "probability": 0.90380859375}, {"start": 65.05, "end": 65.45, "word": " on", "probability": 0.95849609375}, {"start": 65.45, "end": 66.25, "word": " the", "probability": 0.92724609375}, {"start": 66.25, "end": 67.41, "word": " bond", "probability": 0.74853515625}, {"start": 67.41, "end": 67.91, "word": " market", "probability": 0.923828125}, {"start": 67.91, "end": 68.13, "word": " in", "probability": 0.9560546875}, {"start": 68.13, "end": 68.55, "word": " details", "probability": 0.83740234375}], "temperature": 1.0}, {"id": 3, "seek": 9689, "start": 69.27, "end": 96.89, "text": "and the stock market in details fine just to remind you I talk about the main difference between treasury notes and bonds حكينا الفرق بين ال treasury notes و ال treasury bonds التنين يتم إصدارهم من قبل ال government من قبل الحكومة the treasury notes is equal or less than 10 years however the treasury bonds is greater than 10 years to 30 years", "tokens": [474, 264, 4127, 2142, 294, 4365, 2489, 445, 281, 4160, 291, 286, 751, 466, 264, 2135, 2649, 1296, 47213, 5570, 293, 14713, 11331, 4117, 1829, 8315, 27188, 2288, 4587, 49374, 2423, 47213, 5570, 4032, 2423, 47213, 14713, 16712, 1863, 9957, 7251, 39237, 11933, 9381, 3215, 9640, 16095, 9154, 12174, 36150, 2423, 2463, 9154, 12174, 36150, 21542, 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{"start": 88.29, "end": 88.77, "word": " or", "probability": 0.96728515625}, {"start": 88.77, "end": 89.09, "word": " less", "probability": 0.9462890625}, {"start": 89.09, "end": 89.57, "word": " than", "probability": 0.95556640625}, {"start": 89.57, "end": 89.93, "word": " 10", "probability": 0.689453125}, {"start": 89.93, "end": 90.31, "word": " years", "probability": 0.9345703125}, {"start": 90.31, "end": 91.27, "word": " however", "probability": 0.9130859375}, {"start": 91.27, "end": 91.75, "word": " the", "probability": 0.8623046875}, {"start": 91.75, "end": 92.41, "word": " treasury", "probability": 0.9755859375}, {"start": 92.41, "end": 92.85, "word": " bonds", "probability": 0.93408203125}, {"start": 92.85, "end": 93.35, "word": " is", "probability": 0.95458984375}, {"start": 93.35, "end": 94.21, "word": " greater", "probability": 0.88720703125}, {"start": 94.21, "end": 94.67, "word": " than", "probability": 0.95849609375}, {"start": 94.67, "end": 94.97, "word": " 10", "probability": 0.82763671875}, {"start": 94.97, "end": 95.23, "word": " years", "probability": 0.89892578125}, {"start": 95.23, "end": 95.43, "word": " to", "probability": 0.94775390625}, {"start": 95.43, "end": 96.51, "word": " 30", "probability": 0.9599609375}, {"start": 96.51, "end": 96.89, "word": " years", "probability": 0.92724609375}], "temperature": 1.0}, {"id": 4, "seek": 12045, "start": 97.43, "end": 120.45, "text": "أesterday I logged in to the Wall Street Journal and I found some bonds issued or the maturity dates of some bonds up to 43 the day before it was 42 today yesterday I showed some bonds the maturity dates of these bonds up to 43", "tokens": [10721, 4690, 286, 27231, 294, 281, 264, 9551, 7638, 16936, 293, 286, 1352, 512, 14713, 14379, 420, 264, 28874, 11691, 295, 512, 14713, 493, 281, 17914, 264, 786, 949, 309, 390, 14034, 965, 5186, 286, 4712, 512, 14713, 264, 28874, 11691, 295, 613, 14713, 493, 281, 17914], "avg_logprob": -0.3066406212747097, "compression_ratio": 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"word": " 43", "probability": 0.92529296875}, {"start": 109.85, "end": 110.85, "word": " the", "probability": 0.3486328125}, {"start": 110.85, "end": 111.31, "word": " day", "probability": 0.9599609375}, {"start": 111.31, "end": 111.73, "word": " before", "probability": 0.88427734375}, {"start": 111.73, "end": 112.01, "word": " it", "probability": 0.916015625}, {"start": 112.01, "end": 112.27, "word": " was", "probability": 0.95556640625}, {"start": 112.27, "end": 112.75, "word": " 42", "probability": 0.98095703125}, {"start": 112.75, "end": 113.59, "word": " today", "probability": 0.306396484375}, {"start": 113.59, "end": 114.31, "word": " yesterday", "probability": 0.806640625}, {"start": 114.31, "end": 114.93, "word": " I", "probability": 0.96875}, {"start": 114.93, "end": 115.17, "word": " showed", "probability": 0.459228515625}, {"start": 115.17, "end": 115.79, "word": " some", "probability": 0.91455078125}, {"start": 115.79, "end": 117.03, "word": " bonds", "probability": 0.93505859375}, {"start": 117.03, "end": 117.71, "word": " the", "probability": 0.84814453125}, {"start": 117.71, "end": 118.01, "word": " maturity", "probability": 0.9794921875}, {"start": 118.01, "end": 118.31, "word": " dates", "probability": 0.88134765625}, {"start": 118.31, "end": 118.45, "word": " of", "probability": 0.96728515625}, {"start": 118.45, "end": 118.63, "word": " these", "probability": 0.85986328125}, {"start": 118.63, "end": 118.91, "word": " bonds", "probability": 0.86669921875}, {"start": 118.91, "end": 119.47, "word": " up", "probability": 0.96875}, {"start": 119.47, "end": 119.65, "word": " to", "probability": 0.97021484375}, {"start": 119.65, "end": 120.45, "word": " 43", "probability": 0.97509765625}], "temperature": 1.0}, {"id": 5, "seek": 14011, "start": 121.13, "end": 140.11, "text": "I think in your free time is fine to login the www.wsj.com in order to gain some practical experience on how the different market pricing they bond حتى ان انتوا تشوفوا من ناحية العملية كيف الأسواق المالية بتعمل تسعير لأسواق السندات", "tokens": [40, 519, 294, 428, 1737, 565, 307, 2489, 281, 24276, 264, 12520, 13, 14358, 73, 13, 1112, 294, 1668, 281, 6052, 512, 8496, 1752, 322, 577, 264, 819, 2142, 17621, 436, 6086, 11331, 49975, 16472, 16472, 2655, 14407, 6055, 8592, 38688, 14407, 9154, 8717, 39319, 10632, 18863, 42213, 10632, 9122, 33911, 16247, 3794, 14407, 4587, 9673, 6027, 10632, 39894, 25957, 1211, 6055, 3794, 3615, 13546, 5296, 10721, 3794, 14407, 4587, 21136, 41260, 9307], "avg_logprob": -0.11338682543184306, "compression_ratio": 1.4265402843601895, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 121.13, "end": 121.31, "word": "I", "probability": 0.81591796875}, {"start": 121.31, "end": 121.57, "word": " think", "probability": 0.955078125}, {"start": 121.57, "end": 122.07, "word": " in", "probability": 0.8525390625}, {"start": 122.07, "end": 122.23, "word": " your", "probability": 0.92333984375}, {"start": 122.23, "end": 122.43, "word": " 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{"start": 129.51, "end": 129.71, "word": " gain", "probability": 0.91748046875}, {"start": 129.71, "end": 129.99, "word": " some", "probability": 0.90625}, {"start": 129.99, "end": 130.67, "word": " practical", "probability": 0.92822265625}, {"start": 130.67, "end": 131.61, "word": " experience", "probability": 0.91650390625}, {"start": 131.61, "end": 132.07, "word": " on", "probability": 0.9228515625}, {"start": 132.07, "end": 132.35, "word": " how", "probability": 0.953125}, {"start": 132.35, "end": 132.55, "word": " the", "probability": 0.8798828125}, {"start": 132.55, "end": 132.95, "word": " different", "probability": 0.89794921875}, {"start": 132.95, "end": 133.33, "word": " market", "probability": 0.80712890625}, {"start": 133.33, "end": 133.95, "word": " pricing", "probability": 0.92626953125}, {"start": 133.95, "end": 134.53, "word": " they", "probability": 0.7724609375}, {"start": 134.53, "end": 134.79, "word": " bond", "probability": 0.80029296875}, {"start": 134.79, "end": 135.35, "word": " حتى", "probability": 0.85986328125}, {"start": 135.35, "end": 135.51, "word": " ان", "probability": 0.3994140625}, {"start": 135.51, "end": 135.75, "word": " انتوا", "probability": 0.8055013020833334}, {"start": 135.75, "end": 136.01, "word": " تشوفوا", "probability": 0.9945068359375}, {"start": 136.01, "end": 136.11, "word": " من", "probability": 0.9658203125}, {"start": 136.11, "end": 136.33, "word": " ناحية", "probability": 0.9762369791666666}, {"start": 136.33, "end": 136.73, "word": " العملية", "probability": 0.98828125}, {"start": 136.73, "end": 137.11, "word": " كيف", "probability": 0.98046875}, {"start": 137.11, "end": 137.85, "word": " الأسواق", "probability": 0.984130859375}, {"start": 137.85, "end": 138.17, "word": " المالية", "probability": 0.9931640625}, {"start": 138.17, "end": 138.51, "word": " بتعمل", "probability": 0.9900716145833334}, {"start": 138.51, "end": 139.03, "word": " تسعير", "probability": 0.994384765625}, {"start": 139.03, "end": 139.63, "word": " لأسواق", "probability": 0.973046875}, {"start": 139.63, "end": 140.11, "word": " السندات", "probability": 0.9117838541666666}], "temperature": 1.0}, {"id": 6, "seek": 16512, "start": 141.74, "end": 165.12, "text": "inflation protected treasury bonds these bonds are issued to fight against the inflation يعني هذه النوعية من السندات يتم إصدارها حتى تواجه التدخم I don't want to focus on this type of bonds أنا مش هركز على هذه أنواع السندات because this is issued for a particular purposes مش هركز على هذا النوع من السندات", "tokens": [27850, 399, 10594, 47213, 14713, 613, 14713, 366, 14379, 281, 2092, 1970, 264, 15860, 37495, 22653, 29538, 28239, 45367, 10632, 9154, 21136, 41260, 9307, 7251, 39237, 11933, 9381, 3215, 9640, 11296, 11331, 49975, 33427, 26108, 3224, 16712, 3215, 9778, 2304, 286, 500, 380, 528, 281, 1879, 322, 341, 2010, 295, 14713, 41850, 37893, 8032, 31747, 11622, 15844, 29538, 14739, 14407, 3615, 21136, 41260, 9307, 570, 341, 307, 14379, 337, 257, 1729, 9932, 37893, 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0.89453125}, {"start": 147.5, "end": 147.94, "word": " against", "probability": 0.95361328125}, {"start": 147.94, "end": 148.06, "word": " the", "probability": 0.449462890625}, {"start": 148.06, "end": 148.44, "word": " inflation", "probability": 0.8935546875}, {"start": 148.44, "end": 148.72, "word": " يعني", "probability": 0.84716796875}, {"start": 148.72, "end": 148.92, "word": " هذه", "probability": 0.7060546875}, {"start": 148.92, "end": 149.36, "word": " النوعية", "probability": 0.9571940104166666}, {"start": 149.36, "end": 149.54, "word": " من", "probability": 0.935546875}, {"start": 149.54, "end": 150.4, "word": " السندات", "probability": 0.89208984375}, {"start": 150.4, "end": 150.98, "word": " يتم", "probability": 0.905029296875}, {"start": 150.98, "end": 151.38, "word": " إصدارها", "probability": 0.960546875}, {"start": 151.38, "end": 151.62, "word": " حتى", "probability": 0.87451171875}, {"start": 151.62, "end": 152.18, "word": " تواجه", "probability": 0.8553059895833334}, 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" مش", "probability": 0.9931640625}, {"start": 156.88, "end": 157.22, "word": " هركز", "probability": 0.88916015625}, {"start": 157.22, "end": 157.36, "word": " على", "probability": 0.9140625}, {"start": 157.36, "end": 157.62, "word": " هذه", "probability": 0.7587890625}, {"start": 157.62, "end": 157.96, "word": " أنواع", "probability": 0.7726236979166666}, {"start": 157.96, "end": 158.44, "word": " السندات", "probability": 0.98974609375}, {"start": 158.44, "end": 158.98, "word": " because", "probability": 0.93212890625}, {"start": 158.98, "end": 159.32, "word": " this", "probability": 0.94189453125}, {"start": 159.32, "end": 159.54, "word": " is", "probability": 0.95263671875}, {"start": 159.54, "end": 159.9, "word": " issued", "probability": 0.96142578125}, {"start": 159.9, "end": 160.14, "word": " for", "probability": 0.97021484375}, {"start": 160.14, "end": 160.28, "word": " a", "probability": 0.83984375}, {"start": 160.28, "end": 160.78, "word": " particular", "probability": 0.91455078125}, {"start": 160.78, "end": 161.64, "word": " purposes", "probability": 0.84375}, {"start": 161.64, "end": 162.5, "word": " مش", "probability": 0.9287109375}, {"start": 162.5, "end": 162.94, "word": " هركز", "probability": 0.9737955729166666}, {"start": 162.94, "end": 163.1, "word": " على", "probability": 0.947265625}, {"start": 163.1, "end": 163.38, "word": " هذا", "probability": 0.93359375}, {"start": 163.38, "end": 164.44, "word": " النوع", "probability": 0.71826171875}, {"start": 164.44, "end": 164.58, "word": " من", "probability": 0.99169921875}, {"start": 164.58, "end": 165.12, "word": " السندات", "probability": 0.98974609375}], "temperature": 1.0}, {"id": 7, "seek": 18376, "start": 166.44, "end": 183.76, "text": "لأنه هيكون التركيز على treasury notes and bonds و على ال corporate bonds هذا التركيز بتاعنا federal agency debts the same thing I don't want to focus on this مش هركز على international bonds international bonds هي .. هي سندات دولية", "tokens": [1211, 33456, 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0.79638671875}, {"start": 173.82, "end": 174.04, "word": " the", "probability": 0.56103515625}, {"start": 174.04, "end": 174.26, "word": " same", "probability": 0.916015625}, {"start": 174.26, "end": 174.48, "word": " thing", "probability": 0.95751953125}, {"start": 174.48, "end": 174.6, "word": " I", "probability": 0.6259765625}, {"start": 174.6, "end": 174.74, "word": " don't", "probability": 0.9755859375}, {"start": 174.74, "end": 174.92, "word": " want", "probability": 0.9345703125}, {"start": 174.92, "end": 175.02, "word": " to", "probability": 0.9697265625}, {"start": 175.02, "end": 175.34, "word": " focus", "probability": 0.97998046875}, {"start": 175.34, "end": 175.5, "word": " on", "probability": 0.9599609375}, {"start": 175.5, "end": 175.84, "word": " this", "probability": 0.96630859375}, {"start": 175.84, "end": 176.12, "word": " مش", "probability": 0.97119140625}, {"start": 176.12, "end": 176.48, "word": " هركز", "probability": 0.7628580729166666}, {"start": 176.48, "end": 176.66, "word": " على", "probability": 0.7841796875}, {"start": 176.66, "end": 177.74, "word": " international", "probability": 0.33740234375}, {"start": 177.74, "end": 178.42, "word": " bonds", "probability": 0.91015625}, {"start": 178.42, "end": 179.62, "word": " international", "probability": 0.5966796875}, {"start": 179.62, "end": 180.34, "word": " bonds", "probability": 0.9384765625}, {"start": 180.34, "end": 182.5, "word": " هي", "probability": 0.6357421875}, {"start": 182.5, "end": 182.72, "word": " ..", "probability": 0.4453125}, {"start": 182.72, "end": 183.0, "word": " هي", "probability": 0.8330078125}, {"start": 183.0, "end": 183.36, "word": " سندات", "probability": 0.7159830729166666}, {"start": 183.36, "end": 183.76, "word": " دولية", "probability": 0.9899088541666666}], "temperature": 1.0}, {"id": 8, "seek": 20582, "start": 184.64, "end": 205.82, "text": "حيث ال international bonds هم سندات دولية يتم إصدارهم على مستوى دولي so it is marketed in international markets so any company of the United States أي شركة خارج الولايات المتحدة الأمريكية ممكن تشتري هذا السند for instance we have Yankee bonds", "tokens": [5016, 1829, 12984, 2423, 5058, 14713, 8032, 2304, 8608, 41260, 9307, 11778, 12610, 10632, 7251, 39237, 11933, 9381, 3215, 9640, 16095, 15844, 3714, 14851, 2407, 7578, 11778, 12610, 1829, 370, 309, 307, 49089, 294, 5058, 8383, 370, 604, 2237, 295, 264, 2824, 3040, 36632, 13412, 31747, 3660, 16490, 9640, 7435, 2423, 12610, 47302, 9307, 9673, 2655, 24401, 3660, 16247, 2304, 16572, 4117, 10632, 3714, 43020, 6055, 8592, 2655, 16572, 23758, 21136, 41260, 337, 5197, 321, 362, 13633, 21687, 14713], "avg_logprob": -0.1598632849752903, "compression_ratio": 1.4755555555555555, "no_speech_prob": 0.0, "words": [{"start": 184.64, "end": 185.14, "word": "حيث", "probability": 0.67578125}, {"start": 185.14, "end": 185.32, "word": " ال", "probability": 0.99072265625}, {"start": 185.32, "end": 185.76, "word": " international", "probability": 0.9736328125}, {"start": 185.76, "end": 186.32, "word": " bonds", "probability": 0.92138671875}, {"start": 186.32, "end": 186.76, "word": " هم", "probability": 0.7646484375}, {"start": 186.76, "end": 187.12, "word": " سندات", "probability": 0.9495442708333334}, {"start": 187.12, "end": 187.56, "word": " دولية", "probability": 0.9881184895833334}, {"start": 187.56, "end": 188.24, "word": " يتم", "probability": 0.6549072265625}, {"start": 188.24, "end": 188.9, "word": " إصدارهم", "probability": 0.9583984375}, {"start": 188.9, "end": 190.82, "word": " على", "probability": 0.97509765625}, {"start": 190.82, "end": 191.16, "word": " مستوى", "probability": 0.9630126953125}, {"start": 191.16, "end": 191.72, "word": " دولي", "probability": 0.94384765625}, {"start": 191.72, "end": 192.08, "word": " so", "probability": 0.482421875}, {"start": 192.08, "end": 192.22, "word": " it", "probability": 0.97119140625}, {"start": 192.22, "end": 192.36, "word": " is", "probability": 0.92236328125}, {"start": 192.36, "end": 192.74, "word": " marketed", "probability": 0.9208984375}, {"start": 192.74, "end": 193.24, "word": " in", "probability": 0.96142578125}, {"start": 193.24, "end": 194.04, "word": " international", "probability": 0.96142578125}, {"start": 194.04, "end": 194.56, "word": " markets", "probability": 0.8408203125}, {"start": 194.56, "end": 195.12, "word": " so", "probability": 0.7099609375}, {"start": 195.12, "end": 195.46, "word": " any", "probability": 0.88134765625}, {"start": 195.46, "end": 196.24, "word": " company", "probability": 0.93310546875}, {"start": 196.24, "end": 197.14, "word": " of", "probability": 0.97509765625}, {"start": 197.14, "end": 197.3, "word": " the", "probability": 0.88525390625}, {"start": 197.3, "end": 197.56, "word": " United", "probability": 0.5087890625}, {"start": 197.56, "end": 197.96, "word": " States", "probability": 0.876953125}, {"start": 197.96, "end": 198.76, "word": " أي", "probability": 0.58349609375}, {"start": 198.76, "end": 199.64, "word": " شركة", "probability": 0.9923502604166666}, {"start": 199.64, "end": 199.88, "word": " خارج", "probability": 0.9910481770833334}, {"start": 199.88, "end": 200.16, "word": " الولايات", "probability": 0.7675628662109375}, {"start": 200.16, "end": 200.44, "word": " المتحدة", "probability": 0.966796875}, {"start": 200.44, "end": 200.8, "word": " الأمريكية", "probability": 0.94736328125}, {"start": 200.8, "end": 201.08, "word": " ممكن", "probability": 0.989990234375}, {"start": 201.08, "end": 201.62, "word": " تشتري", "probability": 0.9910888671875}, {"start": 201.62, "end": 202.24, "word": " هذا", "probability": 0.9775390625}, {"start": 202.24, "end": 202.84, "word": " السند", "probability": 0.896240234375}, {"start": 202.84, "end": 203.62, "word": " for", "probability": 0.8759765625}, {"start": 203.62, "end": 204.08, "word": " instance", "probability": 0.9599609375}, {"start": 204.08, "end": 204.54, "word": " we", "probability": 0.83837890625}, {"start": 204.54, "end": 204.78, "word": " have", "probability": 0.9677734375}, {"start": 204.78, "end": 205.3, "word": " Yankee", "probability": 0.839111328125}, {"start": 205.3, "end": 205.82, "word": " bonds", "probability": 0.8984375}], "temperature": 1.0}, {"id": 9, "seek": 22738, "start": 206.5, "end": 227.38, "text": "and we have the .. the yen euro bonds these bonds are traded internationally يعني في مثلا عندنا سندات أصدرها اليابان شركات يابانية مثلا بالدولار فبتم التداول فيها بال .. بالسوق الدولي في شركات أمريكية كمان تقوم بإصدار سندات خارج الولايات المتحدة الأمريكية", "tokens": [474, 321, 362, 264, 4386, 264, 21570, 14206, 14713, 613, 14713, 366, 27157, 24422, 37495, 22653, 8978, 50113, 15040, 43242, 8315, 8608, 41260, 9307, 5551, 9381, 3215, 2288, 11296, 45595, 16758, 7649, 13412, 31747, 9307, 7251, 16758, 7649, 10632, 50113, 15040, 20666, 3215, 12610, 9640, 6156, 3555, 39237, 16712, 28259, 12610, 8978, 11296, 20666, 4386, 20666, 3794, 30543, 32748, 12610, 1829, 8978, 13412, 31747, 9307, 5551, 2304, 16572, 4117, 10632, 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I will go back to the .. to the previous slides just to focus on the type now general obligations bonds هاي بتكون التزامات على البلديات أو ال local governments الحكومة المحلية", "tokens": [1766, 2790, 20326, 14713, 11, 341, 4386, 341, 6086, 4386, 286, 486, 352, 646, 281, 264, 4386, 281, 264, 3894, 9788, 445, 281, 1879, 322, 264, 2010, 586, 2674, 26234, 14713, 8032, 47302, 39894, 30544, 16712, 11622, 10943, 9307, 15844, 29739, 1211, 3215, 1829, 9307, 34051, 2423, 2654, 11280, 21542, 4117, 20498, 3660, 9673, 5016, 1211, 10632], "avg_logprob": -0.2023168147124093, "compression_ratio": 1.435483870967742, "no_speech_prob": 2.086162567138672e-06, "words": [{"start": 279.8, "end": 280.2, "word": "general", "probability": 0.6298828125}, {"start": 280.2, "end": 280.58, "word": " obligation", "probability": 0.58251953125}, {"start": 280.58, "end": 281.04, "word": " bonds,", "probability": 0.87255859375}, {"start": 281.72, "end": 282.16, "word": " this", "probability": 0.9228515625}, {"start": 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{"start": 306.92, "end": 307.1, "word": " of", "probability": 0.9814453125}, {"start": 307.1, "end": 307.46, "word": " issuer", "probability": 0.851318359375}, {"start": 307.46, "end": 308.28, "word": " يعني", "probability": 0.92626953125}, {"start": 308.28, "end": 308.88, "word": " البلدية", "probability": 0.9757080078125}, {"start": 308.88, "end": 309.18, "word": " نفسها", "probability": 0.9851888020833334}, {"start": 309.18, "end": 309.64, "word": " بتسد", "probability": 0.8854166666666666}, {"start": 309.64, "end": 310.06, "word": " قيمة", "probability": 0.9962565104166666}, {"start": 310.06, "end": 310.56, "word": " السندات", "probability": 0.8531901041666666}, {"start": 310.56, "end": 310.88, "word": " هذه", "probability": 0.833984375}, {"start": 310.88, "end": 311.84, "word": " من", "probability": 0.65771484375}, {"start": 311.84, "end": 312.36, "word": " خلال", "probability": 0.9931640625}, {"start": 312.36, "end": 313.02, "word": " من", "probability": 0.79150390625}, {"start": 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local governments such as municipals اللي هو البلديات ال government bonds عندنا اللي هو the treasury notes and treasury bonds and we have here the municipal", "tokens": [2407, 10896, 14713, 264, 11280, 14713, 14379, 538, 264, 11280, 420, 2654, 11280, 37495, 22653, 9154, 2423, 11280, 420, 2654, 11280, 2423, 2654, 11280, 1270, 382, 14998, 1124, 13672, 1829, 31439, 29739, 1211, 3215, 1829, 9307, 2423, 2463, 14713, 43242, 8315, 13672, 1829, 31439, 264, 47213, 5570, 293, 47213, 14713, 293, 321, 362, 510, 264, 27177], "avg_logprob": -0.22299890560016297, "compression_ratio": 1.9523809523809523, "no_speech_prob": 0.0, "words": [{"start": 478.13, "end": 478.35, "word": "و", "probability": 0.8857421875}, {"start": 478.35, "end": 478.61, "word": " corporate", "probability": 0.919921875}, {"start": 478.61, "end": 479.05, "word": " bonds", "probability": 0.9130859375}, {"start": 479.05, "end": 482.17, "word": " the", "probability": 0.484130859375}, {"start": 482.17, "end": 482.93, "word": " 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503.75, "end": 505.11, "word": " and", "probability": 0.85205078125}, {"start": 505.11, "end": 505.29, "word": " we", "probability": 0.96337890625}, {"start": 505.29, "end": 505.53, "word": " have", "probability": 0.96923828125}, {"start": 505.53, "end": 505.87, "word": " here", "probability": 0.861328125}, {"start": 505.87, "end": 506.15, "word": " the", "probability": 0.7060546875}, {"start": 506.15, "end": 506.59, "word": " municipal", "probability": 0.8779296875}], "temperature": 1.0}, {"id": 21, "seek": 53888, "start": 509.54, "end": 538.88, "text": "the municipal bonds includes two main bonds the general obligation bonds and revenue bonds and there is another type of bonds called the industrial bonds this industrial bonds is considered as one part of the revenue bonds يعني هو نوع من أنواع ال revenue bonds اللي هو industrial bonds industrial bond اللي هو سندات صناعية", "tokens": [3322, 27177, 14713, 5974, 732, 2135, 14713, 264, 2674, 20326, 14713, 293, 9324, 14713, 293, 456, 307, 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يعني مثلا الحكومة بدها تعمل مناطق صناعية فعشان يتشجع الصناعة في البلد okay فبروح بصدره industrial bonds", "tokens": [3555, 1863, 38251, 1829, 11296, 9987, 14713, 37495, 22653, 4386, 37495, 22653, 50113, 15040, 21542, 4117, 20498, 3660, 47525, 11296, 6055, 25957, 1211, 9154, 41193, 4587, 20328, 8315, 3615, 10632, 6156, 3615, 8592, 7649, 7251, 2655, 8592, 7435, 3615, 31767, 8315, 27884, 8978, 29739, 1211, 3215, 1392, 6156, 26890, 2407, 5016, 4724, 9381, 3215, 2288, 3224, 9987, 14713], "avg_logprob": -0.08746027416091855, "compression_ratio": 1.4052287581699345, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 539.96, "end": 540.48, "word": "بنسميها", "probability": 0.898828125}, {"start": 540.48, "end": 541.02, "word": " industrial", "probability": 0.64013671875}, {"start": 541.02, "end": 541.52, "word": " bonds", "probability": 0.9111328125}, {"start": 541.52, "end": 546.12, "word": " يعني", "probability": 0.906005859375}, {"start": 546.12, "end": 546.64, "word": " ..", 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582.12, "end": 582.2, "word": " ال", "probability": 0.689453125}, {"start": 582.2, "end": 582.44, "word": " corporate", "probability": 0.97607421875}, {"start": 582.44, "end": 582.88, "word": " bonds", "probability": 0.89453125}, {"start": 582.88, "end": 583.28, "word": " اللي", "probability": 0.993408203125}, {"start": 583.28, "end": 583.36, "word": " هو", "probability": 0.986328125}, {"start": 583.36, "end": 583.8, "word": " السندات", "probability": 0.7752278645833334}, {"start": 583.8, "end": 584.22, "word": " الشركات", "probability": 0.9630533854166666}, {"start": 584.22, "end": 584.36, "word": " في", "probability": 0.79638671875}, {"start": 584.36, "end": 584.56, "word": " عندنا", "probability": 0.7364501953125}, {"start": 584.56, "end": 584.92, "word": " نوعين", "probability": 0.994140625}], "temperature": 1.0}, {"id": 24, "seek": 60291, "start": 586.0, "end": 602.92, "text": "النوع اسمه secured bond اللي هو سندات آمنة اسمها secured bond وفي عندنا non secured bond سندات غير آمنة و إيش الفرق بين ال secured و ال non secured؟", "tokens": [6027, 1863, 45367, 24525, 2304, 3224, 22905, 6086, 13672, 1829, 31439, 8608, 41260, 9307, 19753, 27842, 3660, 24525, 2304, 11296, 22905, 6086, 4032, 41185, 43242, 8315, 2107, 22905, 6086, 8608, 41260, 9307, 32771, 13546, 19753, 27842, 3660, 4032, 11933, 1829, 8592, 27188, 2288, 4587, 49374, 2423, 22905, 4032, 2423, 2107, 22905, 22807], "avg_logprob": -0.19251179582667802, "compression_ratio": 1.628787878787879, "no_speech_prob": 0.0, "words": [{"start": 586.0, "end": 586.32, "word": "النوع", "probability": 0.9523111979166666}, {"start": 586.32, "end": 586.6, "word": " اسمه", "probability": 0.9602864583333334}, {"start": 586.6, "end": 587.1, "word": " secured", "probability": 0.82421875}, {"start": 587.1, "end": 587.62, "word": " bond", "probability": 0.70166015625}, {"start": 587.62, "end": 588.34, "word": " اللي", "probability": 0.931640625}, {"start": 588.34, "end": 588.48, "word": " هو", "probability": 0.9248046875}, {"start": 588.48, "end": 588.92, "word": " سندات", "probability": 0.7672526041666666}, {"start": 588.92, "end": 589.48, "word": " آمنة", "probability": 0.7989095052083334}, {"start": 589.48, "end": 590.88, "word": " اسمها", "probability": 0.888671875}, {"start": 590.88, "end": 591.34, "word": " secured", "probability": 0.86376953125}, {"start": 591.34, "end": 591.78, "word": " bond", "probability": 0.9638671875}, {"start": 591.78, "end": 592.7, "word": " وفي", "probability": 0.721923828125}, {"start": 592.7, "end": 592.96, "word": " عندنا", "probability": 0.674560546875}, {"start": 592.96, "end": 593.18, "word": " non", "probability": 0.95654296875}, {"start": 593.18, "end": 593.6, "word": " secured", "probability": 0.5322265625}, {"start": 593.6, "end": 594.16, "word": " bond", "probability": 0.982421875}, {"start": 594.16, "end": 596.26, "word": " سندات", "probability": 0.93994140625}, {"start": 596.26, "end": 596.46, "word": " غير", "probability": 0.995361328125}, {"start": 596.46, "end": 597.1, "word": " آمنة", "probability": 0.97705078125}, {"start": 597.1, "end": 599.94, "word": " و", "probability": 0.67529296875}, {"start": 599.94, "end": 600.68, "word": " إيش", "probability": 0.732177734375}, {"start": 600.68, "end": 601.0, "word": " الفرق", "probability": 0.9698893229166666}, {"start": 601.0, "end": 601.22, "word": " بين", "probability": 0.962890625}, {"start": 601.22, "end": 601.34, "word": " ال", "probability": 0.53564453125}, {"start": 601.34, "end": 601.66, "word": " secured", "probability": 0.7763671875}, {"start": 601.66, "end": 601.8, "word": " و", "probability": 0.91064453125}, {"start": 601.8, "end": 601.84, "word": " ال", "probability": 0.791015625}, {"start": 601.84, "end": 602.0, "word": " non", "probability": 0.9814453125}, {"start": 602.0, "end": 602.92, "word": " secured؟", "probability": 0.75927734375}], "temperature": 1.0}, {"id": 25, "seek": 62453, "start": 603.31, "end": 624.53, "text": "ال secured سندات آمنة يعني انه is the company which issued this part of bonds has a good historical profile يعني الشركة اللي أصدرت هذا النوع من السند الآمن لها good profile يعني سمعتها كويسة و عندها أرباح منيحة و عندها سمعة طيبة however the non secured bond", "tokens": [6027, 22905, 8608, 41260, 9307, 19753, 27842, 3660, 37495, 22653, 16472, 3224, 307, 264, 2237, 597, 14379, 341, 644, 295, 14713, 575, 257, 665, 8584, 7964, 37495, 22653, 25124, 31747, 3660, 13672, 1829, 5551, 9381, 3215, 43500, 23758, 28239, 45367, 9154, 21136, 41260, 6024, 95, 27842, 5296, 11296, 665, 7964, 37495, 22653, 8608, 2304, 34268, 11296, 9122, 45865, 3794, 3660, 4032, 43242, 11296, 5551, 25513, 39319, 9154, 1829, 5016, 3660, 4032, 43242, 11296, 8608, 2304, 27884, 23032, 1829, 49401, 4461, 264, 2107, 22905, 6086], "avg_logprob": -0.14990808332667632, "compression_ratio": 1.5947136563876652, "no_speech_prob": 0.0, "words": [{"start": 603.31, "end": 603.55, "word": "ال", "probability": 0.9140625}, {"start": 603.55, "end": 603.87, "word": " secured", "probability": 0.304931640625}, {"start": 603.87, "end": 604.35, "word": " سندات", "probability": 0.8681640625}, {"start": 604.35, "end": 604.75, "word": " آمنة", "probability": 0.7715657552083334}, {"start": 604.75, "end": 604.99, "word": " يعني", "probability": 0.843505859375}, {"start": 604.99, "end": 605.41, "word": " انه", "probability": 0.6304931640625}, {"start": 605.41, "end": 605.81, "word": " is", "probability": 0.8486328125}, {"start": 605.81, "end": 607.03, "word": " the", "probability": 0.470947265625}, {"start": 607.03, "end": 607.71, "word": " company", "probability": 0.47216796875}, {"start": 607.71, "end": 608.03, "word": " which", "probability": 0.96630859375}, {"start": 608.03, "end": 608.45, "word": " issued", "probability": 0.91650390625}, {"start": 608.45, "end": 608.95, "word": " this", "probability": 0.572265625}, {"start": 608.95, "end": 609.47, "word": " part", "probability": 0.71337890625}, {"start": 609.47, "end": 609.63, "word": " of", "probability": 0.98486328125}, {"start": 609.63, "end": 610.05, "word": " bonds", "probability": 0.79052734375}, {"start": 610.05, "end": 610.89, "word": " has", "probability": 0.9189453125}, {"start": 610.89, "end": 611.15, "word": " a", "probability": 0.99169921875}, {"start": 611.15, "end": 611.31, "word": " good", "probability": 0.9482421875}, {"start": 611.31, "end": 611.73, "word": " historical", "probability": 0.8603515625}, {"start": 611.73, "end": 612.35, "word": " profile", "probability": 0.95751953125}, {"start": 612.35, "end": 612.97, "word": " يعني", "probability": 0.91943359375}, {"start": 612.97, "end": 613.37, "word": " الشركة", "probability": 0.9957682291666666}, {"start": 613.37, "end": 613.49, "word": " اللي", "probability": 0.921630859375}, {"start": 613.49, "end": 614.01, "word": " أصدرت", "probability": 0.9638671875}, {"start": 614.01, "end": 614.95, "word": " هذا", "probability": 0.96240234375}, {"start": 614.95, "end": 615.15, "word": " النوع", "probability": 0.98779296875}, {"start": 615.15, "end": 615.29, "word": " من", "probability": 0.99560546875}, {"start": 615.29, "end": 615.65, "word": " السند", "probability": 0.958984375}, {"start": 615.65, "end": 616.47, "word": " الآمن", "probability": 0.7804361979166666}, {"start": 616.47, "end": 617.05, "word": " لها", "probability": 0.6898193359375}, {"start": 617.05, "end": 617.29, "word": " good", "probability": 0.88671875}, {"start": 617.29, "end": 617.71, "word": " profile", "probability": 0.966796875}, {"start": 617.71, "end": 618.01, "word": " يعني", "probability": 0.88916015625}, {"start": 618.01, "end": 618.67, "word": " سمعتها", "probability": 0.953857421875}, {"start": 618.67, "end": 619.39, "word": " كويسة", "probability": 0.9925537109375}, {"start": 619.39, "end": 619.83, "word": " و", "probability": 0.98388671875}, {"start": 619.83, "end": 620.29, "word": " عندها", "probability": 0.88330078125}, {"start": 620.29, "end": 620.57, "word": " أرباح", "probability": 0.9534505208333334}, {"start": 620.57, "end": 620.97, "word": " منيحة", "probability": 0.9326171875}, {"start": 620.97, "end": 621.09, "word": " و", "probability": 0.9921875}, {"start": 621.09, "end": 621.31, "word": " عندها", "probability": 0.97900390625}, {"start": 621.31, "end": 621.53, "word": " سمعة", "probability": 0.9488932291666666}, {"start": 621.53, "end": 621.87, "word": " طيبة", "probability": 0.97998046875}, {"start": 621.87, "end": 622.91, "word": " however", "probability": 0.7099609375}, {"start": 622.91, "end": 623.23, "word": " the", "probability": 0.7744140625}, {"start": 623.23, "end": 623.65, "word": " non", "probability": 0.9599609375}, {"start": 623.65, "end": 624.09, "word": " secured", "probability": 0.66845703125}, {"start": 624.09, "end": 624.53, "word": " bond", "probability": 0.904296875}], "temperature": 1.0}, {"id": 26, "seek": 63651, "start": 625.27, "end": 636.51, "text": "السندات الغير أمنة non secured bond بيكون الشركة اللي أصدرت هذه النوع من السندات شركة ضعيفة وماعنداش سمعة إمنيها فبيسموها non secured bond", "tokens": [6027, 3794, 41260, 9307, 6024, 118, 13546, 5551, 27842, 3660, 2107, 22905, 6086, 4724, 1829, 30544, 25124, 31747, 3660, 13672, 1829, 5551, 9381, 3215, 43500, 29538, 28239, 45367, 9154, 21136, 41260, 9307, 13412, 31747, 3660, 48812, 3615, 33911, 3660, 4032, 15042, 3615, 41260, 33599, 8608, 2304, 27884, 11933, 2304, 22653, 11296, 6156, 21292, 38251, 2407, 11296, 2107, 22905, 6086], "avg_logprob": -0.15325520411133767, "compression_ratio": 1.547945205479452, "no_speech_prob": 0.0, "words": [{"start": 625.27, "end": 625.91, "word": "السندات", "probability": 0.8416748046875}, {"start": 625.91, "end": 626.35, "word": " الغير", "probability": 0.97314453125}, {"start": 626.35, "end": 626.93, "word": " أمنة", "probability": 0.72265625}, {"start": 626.93, "end": 627.75, "word": " non", "probability": 0.572265625}, {"start": 627.75, "end": 628.11, "word": " secured", "probability": 0.5908203125}, {"start": 628.11, "end": 628.39, "word": " bond", "probability": 0.8359375}, {"start": 628.39, "end": 629.01, "word": " بيكون", "probability": 0.8396809895833334}, {"start": 629.01, "end": 629.47, "word": " الشركة", "probability": 0.99267578125}, {"start": 629.47, "end": 629.59, "word": " اللي", "probability": 0.90576171875}, {"start": 629.59, "end": 630.03, "word": " أصدرت", "probability": 0.9781494140625}, {"start": 630.03, "end": 630.31, "word": " هذه", "probability": 0.84619140625}, {"start": 630.31, "end": 630.49, "word": " النوع", "probability": 0.963134765625}, {"start": 630.49, "end": 630.63, "word": " من", "probability": 0.98583984375}, {"start": 630.63, "end": 631.05, "word": " السندات", "probability": 0.9884440104166666}, {"start": 631.05, "end": 631.49, "word": " شركة", "probability": 0.9938151041666666}, {"start": 631.49, "end": 631.91, "word": " ضعيفة", "probability": 0.985595703125}, {"start": 631.91, "end": 632.39, "word": " وماعنداش", "probability": 0.77822265625}, {"start": 632.39, "end": 632.71, "word": " سمعة", "probability": 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"end": 646.57, "word": " bond", "probability": 0.91162109375}, {"start": 646.57, "end": 647.03, "word": " market", "probability": 0.9013671875}, {"start": 647.03, "end": 647.89, "word": " is", "probability": 0.95947265625}, {"start": 647.89, "end": 648.35, "word": " classified", "probability": 0.95703125}, {"start": 648.35, "end": 648.67, "word": " into", "probability": 0.82177734375}, {"start": 648.67, "end": 648.95, "word": " two", "probability": 0.9111328125}, {"start": 648.95, "end": 649.27, "word": " main", "probability": 0.93115234375}, {"start": 649.27, "end": 649.85, "word": " parts", "probability": 0.88525390625}, {"start": 649.85, "end": 650.45, "word": " the", "probability": 0.6669921875}, {"start": 650.45, "end": 650.69, "word": " first", "probability": 0.89990234375}, {"start": 650.69, "end": 650.87, "word": " one", "probability": 0.94677734375}, {"start": 650.87, "end": 651.01, "word": " the", "probability": 0.71630859375}, {"start": 651.01, "end": 651.37, "word": " government", "probability": 0.375244140625}, {"start": 651.37, "end": 651.85, "word": " and", "probability": 0.7783203125}, {"start": 651.85, "end": 651.99, "word": " the", "probability": 0.88427734375}, {"start": 651.99, "end": 652.21, "word": " second", "probability": 0.90478515625}, {"start": 652.21, "end": 652.45, "word": " one", "probability": 0.92333984375}, {"start": 652.45, "end": 652.67, "word": " is", "probability": 0.95556640625}, {"start": 652.67, "end": 652.99, "word": " the", "probability": 0.8681640625}, {"start": 652.99, "end": 653.97, "word": " corporate", "probability": 0.74658203125}, {"start": 653.97, "end": 655.05, "word": " the", "probability": 0.66259765625}, {"start": 655.05, "end": 655.51, "word": " government", "probability": 0.8564453125}, {"start": 655.51, "end": 656.49, "word": " is", "probability": 0.96484375}, {"start": 656.49, "end": 656.97, "word": " divided", "probability": 0.873046875}, {"start": 656.97, "end": 657.29, "word": " for", "probability": 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0.88623046875}, {"start": 865.18, "end": 865.46, "word": " the", "probability": 0.931640625}, {"start": 865.46, "end": 866.1, "word": " pricing", "probability": 0.8251953125}, {"start": 866.1, "end": 866.6, "word": " system", "probability": 0.95166015625}, {"start": 866.6, "end": 867.9, "word": " okay", "probability": 0.50927734375}, {"start": 867.9, "end": 868.46, "word": " in", "probability": 0.69970703125}, {"start": 868.46, "end": 868.66, "word": " your", "probability": 0.266845703125}, {"start": 868.66, "end": 869.0, "word": " exam", "probability": 0.9921875}], "temperature": 1.0}, {"id": 36, "seek": 87321, "start": 870.55, "end": 873.21, "text": "في الامتحان بتاعكم حاطيكم table", "tokens": [41185, 2423, 10943, 2655, 5016, 7649, 39894, 45761, 24793, 11331, 41193, 1829, 24793, 3199], "avg_logprob": -0.18268229365348815, "compression_ratio": 0.9814814814814815, "no_speech_prob": 0.0, "words": [{"start": 870.55, "end": 870.71, "word": "في", "probability": 0.80322265625}, {"start": 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{"start": 1011.63, "end": 1011.91, "word": " bonds", "probability": 0.908203125}, {"start": 1011.91, "end": 1012.03, "word": " و", "probability": 0.8544921875}, {"start": 1012.03, "end": 1012.09, "word": " ال", "probability": 0.779296875}, {"start": 1012.09, "end": 1012.41, "word": " yankee", "probability": 0.669189453125}, {"start": 1012.41, "end": 1012.85, "word": " bonds", "probability": 0.931640625}, {"start": 1012.85, "end": 1014.03, "word": " ال", "probability": 0.94482421875}, {"start": 1014.03, "end": 1014.55, "word": " euro", "probability": 0.88037109375}, {"start": 1014.55, "end": 1014.91, "word": " bonds", "probability": 0.9287109375}, {"start": 1014.91, "end": 1015.39, "word": " is", "probability": 0.943359375}, {"start": 1015.39, "end": 1016.79, "word": " bond", "probability": 0.8505859375}, {"start": 1016.79, "end": 1018.61, "word": " issued", "probability": 0.88720703125}, {"start": 1018.61, "end": 1019.11, "word": " of", "probability": 0.90234375}, {"start": 1019.11, "end": 1019.49, "word": " the", "probability": 0.91162109375}, {"start": 1019.49, "end": 1019.77, "word": " united", "probability": 0.66357421875}, {"start": 1019.77, "end": 1020.23, "word": " states", "probability": 0.9541015625}], "temperature": 1.0}, {"id": 42, "seek": 104315, "start": 1021.27, "end": 1043.15, "text": "يعني هي سندات تصدر خارج المولايات المتحدة الأمريكية in the dollar amount بقيمة الدولار and .. and I explain why some institutions issued bonds or dollar bonds of the United States لأنه ت escape .. ت escape from the regulations of the Federal Reserve Bank", "tokens": [40228, 22653, 39896, 8608, 41260, 9307, 6055, 9381, 3215, 2288, 16490, 9640, 7435, 9673, 12610, 47302, 9307, 9673, 2655, 24401, 3660, 16247, 2304, 16572, 4117, 10632, 294, 264, 7241, 2372, 4724, 4587, 32640, 3660, 32748, 12610, 9640, 293, 4386, 293, 286, 2903, 983, 512, 8142, 14379, 14713, 420, 7241, 14713, 295, 264, 2824, 3040, 5296, 33456, 3224, 6055, 7615, 4386, 6055, 7615, 490, 264, 12563, 295, 264, 12380, 26049, 8915], "avg_logprob": -0.1291813418059282, "compression_ratio": 1.3982300884955752, "no_speech_prob": 0.0, "words": [{"start": 1021.27, "end": 1021.71, "word": "يعني", "probability": 0.939208984375}, {"start": 1021.71, "end": 1021.95, "word": " هي", "probability": 0.86767578125}, {"start": 1021.95, "end": 1022.59, "word": " سندات", "probability": 0.822265625}, {"start": 1022.59, "end": 1023.69, "word": " تصدر", "probability": 0.9932861328125}, {"start": 1023.69, "end": 1024.07, "word": " خارج", "probability": 0.99560546875}, {"start": 1024.07, "end": 1024.49, "word": " المولايات", "probability": 0.69439697265625}, {"start": 1024.49, "end": 1024.93, "word": " المتحدة", "probability": 0.919921875}, {"start": 1024.93, "end": 1025.59, "word": " الأمريكية", "probability": 0.9849609375}, {"start": 1025.59, "end": 1025.89, "word": " in", "probability": 0.91015625}, {"start": 1025.89, "end": 1026.01, "word": " the", "probability": 0.8955078125}, {"start": 1026.01, "end": 1026.31, "word": " dollar", "probability": 0.90625}, {"start": 1026.31, "end": 1026.99, "word": " amount", "probability": 0.873046875}, {"start": 1026.99, "end": 1028.15, "word": " بقيمة", "probability": 0.8760986328125}, {"start": 1028.15, "end": 1028.57, "word": " الدولار", "probability": 0.9501953125}, {"start": 1028.57, "end": 1029.57, "word": " and", "probability": 0.81640625}, {"start": 1029.57, "end": 1029.75, "word": " ..", "probability": 0.64990234375}, {"start": 1029.75, "end": 1029.95, "word": " and", "probability": 0.90380859375}, {"start": 1029.95, "end": 1030.15, "word": " I", "probability": 0.931640625}, {"start": 1030.15, "end": 1030.65, "word": " explain", "probability": 0.481689453125}, {"start": 1030.65, "end": 1031.99, "word": " why", "probability": 0.9755859375}, {"start": 1031.99, "end": 1032.33, "word": " some", "probability": 0.92626953125}, {"start": 1032.33, "end": 1033.17, "word": " institutions", "probability": 0.94921875}, {"start": 1033.17, "end": 1034.31, "word": " issued", "probability": 0.923828125}, {"start": 1034.31, "end": 1036.49, "word": " bonds", "probability": 0.8046875}, {"start": 1036.49, "end": 1037.19, "word": " or", "probability": 0.85205078125}, {"start": 1037.19, "end": 1037.63, "word": " dollar", "probability": 0.93359375}, {"start": 1037.63, "end": 1038.03, "word": " bonds", "probability": 0.89306640625}, {"start": 1038.03, "end": 1038.31, "word": " of", "probability": 0.97265625}, {"start": 1038.31, "end": 1038.41, "word": " the", "probability": 0.91650390625}, {"start": 1038.41, "end": 1038.61, "word": " United", "probability": 0.70849609375}, {"start": 1038.61, "end": 1038.95, "word": " States", "probability": 0.90234375}, {"start": 1038.95, "end": 1039.53, "word": " لأنه", "probability": 0.8650716145833334}, {"start": 1039.53, "end": 1039.57, "word": " ت", "probability": 0.974609375}, {"start": 1039.57, "end": 1039.93, "word": " escape", "probability": 0.9326171875}, {"start": 1039.93, "end": 1040.39, "word": " ..", "probability": 0.9453125}, {"start": 1040.39, "end": 1040.53, "word": " ت", "probability": 0.80322265625}, {"start": 1040.53, "end": 1040.93, "word": " escape", "probability": 0.919921875}, {"start": 1040.93, "end": 1041.25, "word": " from", "probability": 0.9365234375}, {"start": 1041.25, "end": 1041.41, "word": " the", "probability": 0.9326171875}, {"start": 1041.41, "end": 1041.85, "word": " regulations", "probability": 0.89111328125}, {"start": 1041.85, "end": 1042.15, "word": " of", "probability": 0.97607421875}, {"start": 1042.15, "end": 1042.27, "word": " the", "probability": 0.91015625}, {"start": 1042.27, "end": 1042.51, "word": " Federal", "probability": 0.5361328125}, {"start": 1042.51, "end": 1042.79, "word": " Reserve", "probability": 0.9267578125}, {"start": 1042.79, "end": 1043.15, "word": " Bank", "probability": 0.93505859375}], "temperature": 1.0}, {"id": 43, "seek": 106967, "start": 1043.53, "end": 1069.67, "text": "يعني عشان يخرجوا من سيطرة ال .. البنك الفيدرالي الأمريكي و بتكون زي ما اتفضلتها انه ال .. ال .. الإيراد او ال return عالي كتير في مقارنة مع inside the united states ال yankee bonds which is the opposite of euro bonds عكسه تمام it means non united states bonds in the united states تبقى is non united states companies in the united states", "tokens": [40228, 22653, 6225, 8592, 7649, 7251, 34740, 7435, 14407, 9154, 8608, 1829, 9566, 25720, 2423, 4386, 29739, 1863, 4117, 27188, 25708, 2288, 6027, 1829, 16247, 2304, 16572, 4117, 1829, 4032, 39894, 30544, 30767, 1829, 19446, 1975, 2655, 5172, 11242, 1211, 2655, 11296, 16472, 3224, 2423, 4386, 2423, 4386, 33688, 13546, 18513, 1975, 2407, 2423, 2736, 6225, 6027, 1829, 9122, 2655, 13546, 8978, 3714, 4587, 9640, 1863, 3660, 20449, 1854, 264, 18883, 4368, 2423, 17700, 21687, 14713, 597, 307, 264, 6182, 295, 14206, 14713, 6225, 4117, 3794, 3224, 46811, 10943, 309, 1355, 2107, 18883, 4368, 14713, 294, 264, 18883, 4368, 6055, 3555, 4587, 7578, 307, 2107, 18883, 4368, 3431, 294, 264, 18883, 4368], 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"probability": 0.587158203125}, {"start": 1055.25, "end": 1055.75, "word": " bonds", "probability": 0.69140625}, {"start": 1055.75, "end": 1056.89, "word": " which", "probability": 0.92041015625}, {"start": 1056.89, "end": 1057.15, "word": " is", "probability": 0.9736328125}, {"start": 1057.15, "end": 1057.41, "word": " the", "probability": 0.9296875}, {"start": 1057.41, "end": 1057.77, "word": " opposite", "probability": 0.95458984375}, {"start": 1057.77, "end": 1058.05, "word": " of", "probability": 0.98681640625}, {"start": 1058.05, "end": 1058.25, "word": " euro", "probability": 0.34033203125}, {"start": 1058.25, "end": 1058.69, "word": " bonds", "probability": 0.87548828125}, {"start": 1058.69, "end": 1059.77, "word": " عكسه", "probability": 0.9813232421875}, {"start": 1059.77, "end": 1060.03, "word": " تمام", "probability": 0.996337890625}, {"start": 1060.03, "end": 1060.25, "word": " it", "probability": 0.61181640625}, {"start": 1060.25, "end": 1060.59, "word": " means", 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1124.56, "end": 1124.72, "word": " a", "probability": 0.6279296875}, {"start": 1124.72, "end": 1125.04, "word": " Yankee", "probability": 0.74072265625}, {"start": 1125.04, "end": 1125.5, "word": " bond", "probability": 0.86376953125}, {"start": 1125.5, "end": 1126.14, "word": " يعني", "probability": 0.875732421875}, {"start": 1126.14, "end": 1126.34, "word": " إذا", "probability": 0.903564453125}, {"start": 1126.34, "end": 1126.7, "word": " كانت", "probability": 0.980712890625}, {"start": 1126.7, "end": 1126.88, "word": " ريم", "probability": 0.6910400390625}, {"start": 1126.88, "end": 1127.74, "word": " أصدرت", "probability": 0.979736328125}, {"start": 1127.74, "end": 1128.68, "word": " سنة", "probability": 0.7511393229166666}, {"start": 1128.68, "end": 1129.22, "word": " داخل", "probability": 0.9482421875}, {"start": 1129.22, "end": 1129.5, "word": " ولاية", "probability": 0.6865234375}, {"start": 1129.5, "end": 1129.86, "word": " المتحدة", "probability": 0.728515625}, {"start": 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"probability": 0.71826171875}, {"start": 1155.08, "end": 1155.34, "word": " United", "probability": 0.55224609375}, {"start": 1155.34, "end": 1155.74, "word": " States", "probability": 0.9130859375}, {"start": 1155.74, "end": 1155.94, "word": " هذا", "probability": 0.73388671875}, {"start": 1155.94, "end": 1156.12, "word": " ال", "probability": 0.90234375}, {"start": 1156.12, "end": 1156.32, "word": " bond", "probability": 0.9658203125}, {"start": 1156.32, "end": 1157.54, "word": " بنسميه", "probability": 0.892333984375}, {"start": 1157.54, "end": 1157.94, "word": " Yankee", "probability": 0.7451171875}, {"start": 1157.94, "end": 1158.32, "word": " bond", "probability": 0.75341796875}, {"start": 1158.32, "end": 1159.54, "word": " فواضح", "probability": 0.9613037109375}, {"start": 1159.54, "end": 1159.82, "word": " انكم", "probability": 0.5924072265625}, {"start": 1159.82, "end": 1160.04, "word": " what", "probability": 0.966796875}, {"start": 1160.04, "end": 1160.16, "word": " it", "probability": 0.94580078125}, {"start": 1160.16, "end": 1160.34, "word": " means", "probability": 0.9443359375}, {"start": 1160.34, "end": 1160.64, "word": " Yankee", "probability": 0.9580078125}, {"start": 1160.64, "end": 1160.98, "word": " bond", "probability": 0.8955078125}, {"start": 1160.98, "end": 1162.36, "word": " okay", "probability": 0.56591796875}], "temperature": 1.0}, {"id": 48, "seek": 118896, "start": 1164.54, "end": 1188.96, "text": "and I talk about the municipal bonds the main characteristics of the municipal bonds واحدة من الخصائص سبعة ال municipal bonds is tax exempted what it means tax exempted it means أن السند اللي بتصدره البلدية هو خالي من الضريبة أو معفي من الضريبة", "tokens": [474, 286, 751, 466, 264, 27177, 14713, 264, 2135, 10891, 295, 264, 27177, 14713, 36764, 24401, 3660, 9154, 33962, 9381, 16373, 9381, 8608, 3555, 27884, 2423, 27177, 14713, 307, 3366, 30425, 292, 437, 309, 1355, 3366, 30425, 292, 309, 1355, 14739, 21136, 41260, 13672, 1829, 39894, 9381, 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1207.23, "text": "is tax exempted خالي من الدريبة so the investors are comparing between the bond with a tax and the bond is tax exempted يعني المستثمرين يقارنوا بين نوعين من السندات السند اللي عليه دريبة والسند اللي معه فيه بالدريبة", "tokens": [271, 3366, 30425, 292, 16490, 6027, 1829, 9154, 32748, 16572, 49401, 370, 264, 11519, 366, 15763, 1296, 264, 6086, 365, 257, 3366, 293, 264, 6086, 307, 3366, 30425, 292, 37495, 22653, 9673, 14851, 12984, 29973, 9957, 7251, 4587, 9640, 1863, 14407, 49374, 8717, 45367, 9957, 9154, 21136, 41260, 9307, 21136, 41260, 13672, 1829, 47356, 11778, 16572, 49401, 16070, 3794, 41260, 13672, 1829, 20449, 3224, 8978, 3224, 20666, 3215, 16572, 49401], "avg_logprob": -0.1626320477102844, "compression_ratio": 1.701657458563536, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 1189.87, "end": 1190.13, "word": "is", "probability": 0.71044921875}, {"start": 1190.13, "end": 1190.41, "word": " tax", "probability": 0.9501953125}, {"start": 1190.41, 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1196.71, "end": 1197.51, "word": " with", "probability": 0.9267578125}, {"start": 1197.51, "end": 1198.15, "word": " a", "probability": 0.96826171875}, {"start": 1198.15, "end": 1198.53, "word": " tax", "probability": 0.95166015625}, {"start": 1198.53, "end": 1199.33, "word": " and", "probability": 0.96875}, {"start": 1199.33, "end": 1199.61, "word": " the", "probability": 0.84423828125}, {"start": 1199.61, "end": 1199.93, "word": " bond", "probability": 0.927734375}, {"start": 1199.93, "end": 1200.35, "word": " is", "probability": 0.94091796875}, {"start": 1200.35, "end": 1200.61, "word": " tax", "probability": 0.94775390625}, {"start": 1200.61, "end": 1201.23, "word": " exempted", "probability": 0.938232421875}, {"start": 1201.23, "end": 1201.53, "word": " يعني", "probability": 0.91357421875}, {"start": 1201.53, "end": 1202.05, "word": " المستثمرين", "probability": 0.94697265625}, {"start": 1202.05, "end": 1202.43, "word": " يقارنوا", "probability": 0.90888671875}, {"start": 1202.43, "end": 1202.85, "word": " بين", "probability": 0.74658203125}, {"start": 1202.85, "end": 1203.15, "word": " نوعين", "probability": 0.9202473958333334}, {"start": 1203.15, "end": 1203.29, "word": " من", "probability": 0.9755859375}, {"start": 1203.29, "end": 1203.83, "word": " السندات", "probability": 0.9189453125}, {"start": 1203.83, "end": 1204.81, "word": " السند", "probability": 0.8955078125}, {"start": 1204.81, "end": 1205.07, "word": " اللي", "probability": 0.925537109375}, {"start": 1205.07, "end": 1205.57, "word": " عليه", "probability": 0.73779296875}, {"start": 1205.57, "end": 1205.95, "word": " دريبة", "probability": 0.92138671875}, {"start": 1205.95, "end": 1206.29, "word": " والسند", "probability": 0.8522135416666666}, {"start": 1206.29, "end": 1206.45, "word": " اللي", "probability": 0.80712890625}, {"start": 1206.45, "end": 1206.61, "word": " معه", "probability": 0.506103515625}, {"start": 1206.61, "end": 1206.73, "word": " فيه", "probability": 0.862548828125}, {"start": 1206.73, "end": 1207.23, "word": " بالدريبة", "probability": 0.83148193359375}], "temperature": 1.0}, {"id": 50, "seek": 122949, "start": 1207.45, "end": 1229.49, "text": "يعني أي investors بدهم يعمل قرار استثمار بيقارنه بين two different types of bonds بيقارنه نوعين من ال bonds السند اللي عليه ضريبة و السند اللي معاه فيه من الضريبة how they do this كيف بيعملوا كلام هذا I will show you how they do this كيف هم بيعملوا conversion between the taxable bonds and non-taxable bonds or tax exempted bonds", "tokens": [40228, 22653, 36632, 11519, 47525, 16095, 7251, 25957, 1211, 12174, 2288, 9640, 44713, 12984, 2304, 9640, 4724, 1829, 4587, 9640, 1863, 3224, 49374, 732, 819, 3467, 295, 14713, 4724, 1829, 4587, 9640, 1863, 3224, 8717, 45367, 9957, 9154, 2423, 14713, 21136, 41260, 13672, 1829, 47356, 48812, 16572, 49401, 4032, 21136, 41260, 13672, 1829, 20449, 40294, 8978, 3224, 9154, 6024, 114, 16572, 49401, 577, 436, 360, 341, 9122, 33911, 4724, 1829, 25957, 1211, 14407, 28242, 10943, 23758, 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0.94921875}, {"start": 1356.55, "end": 1357.05, "word": " R", "probability": 0.9453125}, {"start": 1357.05, "end": 1358.01, "word": " is", "probability": 0.95703125}, {"start": 1358.01, "end": 1358.47, "word": " the", "probability": 0.9130859375}, {"start": 1358.47, "end": 1359.05, "word": " taxable", "probability": 0.981689453125}, {"start": 1359.05, "end": 1359.43, "word": " bonds", "probability": 0.76806640625}], "temperature": 1.0}, {"id": 56, "seek": 138324, "start": 1360.16, "end": 1383.24, "text": "So again RM is tax free يعني ماعلوش ضريبة و R هو عليه ضريبة and we compare between two of them but this is because this has a taxation so we have to pay tax so we deduct tax from this لازم نختم منه ضريبة صح؟ So deducted tax is one minus T", "tokens": [6455, 797, 23790, 307, 3366, 1737, 37495, 22653, 19446, 30241, 2407, 8592, 48812, 16572, 49401, 4032, 497, 31439, 47356, 48812, 16572, 49401, 293, 321, 6794, 1296, 732, 295, 552, 457, 341, 307, 570, 341, 575, 257, 47072, 370, 321, 362, 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"seek": 143625, "start": 1408.77, "end": 1436.25, "text": "Okay R is the taxable bonds السند اللي عليه ضريبة So we are comparing between this and this We are in other words احنا بنقارن بالسند اللي عليه ضريبة في عائد السند اللي عليه ضريبة وعائد السند اللي ماعفيه من الضريبة Okay So if this equal Y it means if R is greater than RM", "tokens": [8297, 497, 307, 264, 3366, 712, 14713, 21136, 41260, 13672, 1829, 47356, 48812, 16572, 49401, 407, 321, 366, 15763, 1296, 341, 293, 341, 492, 366, 294, 661, 2283, 1975, 5016, 8315, 44945, 4587, 9640, 1863, 20666, 3794, 41260, 13672, 1829, 47356, 48812, 16572, 49401, 8978, 6225, 16373, 3215, 21136, 41260, 13672, 1829, 47356, 48812, 16572, 49401, 4032, 3615, 16373, 3215, 21136, 41260, 13672, 1829, 19446, 3615, 41185, 3224, 9154, 6024, 114, 16572, 49401, 1033, 407, 498, 341, 2681, 398, 309, 1355, 498, 497, 307, 5044, 813, 23790], "avg_logprob": -0.17942116511139003, "compression_ratio": 1.8137254901960784, "no_speech_prob": 5.960464477539063e-08, 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greater than RM we prefer RM this is very simple", "tokens": [1211, 33456, 3224, 44945, 5016, 35457, 2423, 497, 934, 3366, 37495, 22653, 12174, 3215, 33599, 39182, 6024, 114, 16572, 49401, 293, 550, 934, 300, 321, 6794, 1296, 552, 498, 497, 307, 5044, 813, 23790, 370, 321, 352, 337, 497, 5911, 4386, 5911, 37495, 22653, 11933, 15730, 19446, 41361, 8592, 2423, 28820, 10943, 23758, 321, 352, 337, 23790, 37495, 22653, 11933, 15730, 25961, 18863, 4117, 3794, 307, 264, 6182, 498, 23790, 307, 5044, 813, 23790, 321, 4382, 23790, 341, 307, 588, 2199], "avg_logprob": -0.16015624745589932, "compression_ratio": 1.5644444444444445, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1465.36, "end": 1465.84, "word": "لأنه", "probability": 0.8155924479166666}, {"start": 1465.84, "end": 1466.62, "word": " بنحسب", "probability": 0.9405924479166666}, {"start": 1466.62, "end": 1466.84, "word": " ال", "probability": 0.89892578125}, {"start": 1466.84, "end": 1467.02, "word": " R", "probability": 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"temperature": 1.0}, {"id": 64, "seek": 158709, "start": 1573.41, "end": 1587.09, "text": "and RM اللي احنا شرحناها ال RM شفتوها denote the municipal bonds اللي هي السند بتاع البلدية وحكينا ال municipal bonds هو is tax exempted", "tokens": [474, 23790, 13672, 1829, 1975, 5016, 8315, 13412, 2288, 5016, 8315, 11296, 2423, 23790, 13412, 5172, 2655, 2407, 11296, 45708, 264, 27177, 14713, 13672, 1829, 39896, 21136, 41260, 39894, 45761, 29739, 1211, 3215, 10632, 4032, 5016, 4117, 1829, 8315, 2423, 27177, 14713, 31439, 307, 3366, 30425, 292], "avg_logprob": -0.13557942459980646, "compression_ratio": 1.3450704225352113, "no_speech_prob": 0.0, "words": [{"start": 1573.41, "end": 1573.75, "word": "and", "probability": 0.69384765625}, {"start": 1573.75, "end": 1574.29, "word": " RM", "probability": 0.89208984375}, {"start": 1574.29, "end": 1575.11, "word": " اللي", "probability": 0.856689453125}, {"start": 1575.11, "end": 1575.27, "word": " احنا", "probability": 0.9186197916666666}, {"start": 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أنا حكيته إذا كان R1-T اللي شايفينها is greater than RM so in this case we prefer the taxable bonds otherwise the tax exempted bond is preferable okay how we calculate the", "tokens": [40753, 260, 813, 23790, 550, 264, 3366, 712, 6086, 2709, 257, 2946, 3314, 295, 2736, 5911, 264, 27177, 6086, 307, 16494, 30767, 1829, 19446, 41850, 11331, 4117, 36081, 3224, 11933, 15730, 25961, 497, 16, 12, 51, 13672, 1829, 13412, 995, 33911, 9957, 11296, 307, 5044, 813, 23790, 370, 294, 341, 1389, 321, 4382, 264, 3366, 712, 14713, 5911, 264, 3366, 30425, 292, 6086, 307, 4382, 712, 1392, 577, 321, 8873, 264], "avg_logprob": -0.18652343646519715, "compression_ratio": 1.488262910798122, "no_speech_prob": 0.0, "words": [{"start": 1607.39, "end": 1607.95, "word": "greater", "probability": 0.5114212036132812}, {"start": 1607.95, "end": 1608.17, "word": " than", "probability": 0.9541015625}, {"start": 1608.17, "end": 1608.61, "word": " RM", "probability": 0.95556640625}, {"start": 1608.61, "end": 1609.77, 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"end": 1780.07, "word": " the", "probability": 0.89013671875}, {"start": 1780.07, "end": 1780.59, "word": " taxable", "probability": 0.98583984375}, {"start": 1780.59, "end": 1781.03, "word": " one", "probability": 0.947265625}, {"start": 1781.03, "end": 1781.81, "word": " يعني", "probability": 0.91845703125}, {"start": 1781.81, "end": 1782.39, "word": " بتشوف", "probability": 0.7613932291666666}, {"start": 1782.39, "end": 1782.91, "word": " جداش", "probability": 0.618896484375}, {"start": 1782.91, "end": 1785.29, "word": " العائد", "probability": 0.94189453125}, {"start": 1785.29, "end": 1785.55, "word": " على", "probability": 0.79296875}, {"start": 1785.55, "end": 1785.75, "word": " ال", "probability": 0.57421875}, {"start": 1785.75, "end": 1786.27, "word": " taxable", "probability": 0.968017578125}, {"start": 1786.27, "end": 1786.93, "word": " على", "probability": 0.826171875}, {"start": 1786.93, "end": 1787.33, "word": " السند", "probability": 0.786376953125}, {"start": 1787.33, 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five percent taxable bond is equal one percent tax exempted bond يعني لو احنا أخدنا سند عليه ضريبة الواحد فاصلة اتنين فاصلة خمسة after tax هيساوي واحد فلمية على سند معفي من الضريبة لو احنا أخدنا هان كمان", "tokens": [7649, 2655, 3555, 3224, 14407, 8032, 7649, 472, 935, 7699, 1732, 3043, 3366, 712, 6086, 307, 2681, 472, 3043, 3366, 30425, 292, 6086, 37495, 22653, 45164, 1975, 5016, 8315, 5551, 9778, 3215, 8315, 8608, 41260, 47356, 48812, 16572, 49401, 2423, 14407, 24401, 6156, 33546, 37977, 1975, 2655, 1863, 9957, 6156, 33546, 37977, 16490, 2304, 3794, 3660, 934, 3366, 39896, 3794, 995, 45865, 36764, 24401, 6156, 19528, 10632, 15844, 8608, 41260, 20449, 41185, 9154, 6024, 114, 16572, 49401, 45164, 1975, 5016, 8315, 5551, 9778, 3215, 8315, 8032, 7649, 9122, 2304, 7649], "avg_logprob": -0.17573831991834954, "compression_ratio": 1.6796116504854368, "no_speech_prob": 0.0, "words": [{"start": 1859.67, "end": 1860.33, "word": "انتبهوا", "probability": 0.8240234375}, {"start": 1860.33, "end": 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where أي واحدة؟ هذه؟ نفس الطريقة هذه نفسي أنا بس ورجيتك واحدة تانية مش هورجيك الكل طلعنا ال equivalence طلعنا هذه ال T طلعنا أنه متى هذا بيساوي هذا", "tokens": [8297, 22807, 9122, 33911, 22807, 689, 36632, 36764, 24401, 3660, 22807, 29538, 22807, 8717, 36178, 41950, 16572, 28671, 29538, 8717, 36178, 1829, 41850, 4724, 3794, 4032, 47341, 36081, 4117, 36764, 24401, 3660, 6055, 7649, 10632, 37893, 8032, 13063, 7435, 1829, 4117, 2423, 28820, 23032, 1211, 3615, 8315, 2423, 9052, 655, 23032, 1211, 3615, 8315, 29538, 2423, 314, 23032, 1211, 3615, 8315, 14739, 3224, 44650, 7578, 23758, 4724, 1829, 3794, 995, 45865, 23758], "avg_logprob": -0.24443492497483346, "compression_ratio": 1.5497076023391814, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1920.2900000000002, "end": 1921.0900000000001, "word": "Okay؟", "probability": 0.4381103515625}, {"start": 1921.0900000000001, "end": 1921.89, "word": " كيف؟", "probability": 0.7699381510416666}, {"start": 1921.89, "end": 1924.37, "word": " where", "probability": 0.296630859375}, {"start": 1924.37, "end": 1924.59, "word": " أي", "probability": 0.7548828125}, {"start": 1924.59, "end": 1924.91, "word": " واحدة؟", "probability": 0.7901611328125}, {"start": 1924.91, "end": 1927.69, "word": " هذه؟", "probability": 0.666015625}, {"start": 1927.69, "end": 1928.41, "word": " نفس", "probability": 0.992919921875}, {"start": 1928.41, "end": 1928.75, "word": " الطريقة", "probability": 0.98828125}, {"start": 1928.75, "end": 1928.95, "word": " هذه", "probability": 0.51708984375}, {"start": 1928.95, "end": 1930.41, "word": " نفسي", "probability": 0.6874186197916666}, {"start": 1930.41, "end": 1930.57, "word": " أنا", "probability": 0.60498046875}, {"start": 1930.57, "end": 1930.75, "word": " بس", "probability": 0.927734375}, {"start": 1930.75, "end": 1931.15, "word": " ورجيتك", "probability": 0.9161376953125}, {"start": 1931.15, "end": 1931.37, "word": " واحدة", "probability": 0.9892578125}, {"start": 1931.37, "end": 1931.73, "word": " تانية", "probability": 0.5697021484375}, {"start": 1931.73, "end": 1931.83, "word": " مش", "probability": 0.75244140625}, {"start": 1931.83, "end": 1932.21, "word": " هورجيك", "probability": 0.95625}, {"start": 1932.21, "end": 1932.51, "word": " الكل", "probability": 0.730224609375}, {"start": 1932.51, "end": 1935.85, "word": " طلعنا", "probability": 0.9625244140625}, {"start": 1935.85, "end": 1935.93, "word": " ال", "probability": 0.9765625}, {"start": 1935.93, "end": 1936.61, "word": " equivalence", "probability": 0.631591796875}, {"start": 1936.61, "end": 1938.15, "word": " طلعنا", "probability": 0.986083984375}, {"start": 1938.15, "end": 1938.47, "word": " هذه", "probability": 0.759765625}, {"start": 1938.47, "end": 1939.51, "word": " ال", "probability": 0.9208984375}, {"start": 1939.51, "end": 1939.77, "word": " T", "probability": 0.88232421875}, {"start": 1939.77, "end": 1941.97, "word": " طلعنا", "probability": 0.9915771484375}, {"start": 1941.97, "end": 1942.49, "word": " 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you the tax exempted و بعطيك الدريبة and I'm asking you what is the equivalent rate of return if you know this بال equivalent rate of return يعني متى ال R هتساوي ال RM you understand؟ بس ال RM هي النمر اللي بيبقى بالعالم", "tokens": [3224, 1829, 3555, 4587, 7578, 1975, 8315, 4386, 1975, 8315, 23758, 2423, 4386, 2423, 3199, 23758, 37893, 3714, 29245, 23328, 1975, 9381, 15040, 293, 286, 445, 976, 291, 264, 3366, 30425, 292, 4032, 4724, 3615, 9566, 1829, 4117, 32748, 16572, 49401, 293, 286, 478, 3365, 291, 437, 307, 264, 10344, 3314, 295, 2736, 498, 291, 458, 341, 20666, 10344, 3314, 295, 2736, 37495, 22653, 44650, 7578, 2423, 497, 8032, 2655, 3794, 995, 45865, 2423, 23790, 291, 1223, 22807, 4724, 3794, 2423, 23790, 39896, 28239, 2304, 2288, 13672, 1829, 4724, 1829, 3555, 4587, 7578, 20666, 3615, 45340], "avg_logprob": -0.26304767058067713, "compression_ratio": 1.556910569105691, "no_speech_prob": 8.344650268554688e-07, "words": [{"start": 2046.8, "end": 2047.36, "word": "هيبقى", 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مرة ضريبة هو كويس فال investors أول ما بيطلع لازم يحسب ال return من هاد و ال return من هاد و بيعمل comparison between them إذا كان ال return من ال taxable أفضل فأنا بروح على ال taxable if the return of the exempted so I prefer the exempted لأن ال .. the ..", "tokens": [2304, 8592, 11778, 47302, 15042, 21136, 41260, 13672, 1829, 19446, 3615, 1863, 2407, 8592, 48812, 16572, 49401, 307, 4382, 712, 37893, 4386, 37893, 11778, 47302, 15042, 4724, 8315, 2655, 37893, 11778, 47302, 15042, 21136, 41260, 13672, 1829, 47356, 13672, 1829, 20449, 40294, 8978, 3224, 3714, 25720, 48812, 16572, 49401, 31439, 9122, 45865, 3794, 6156, 6027, 11519, 5551, 12610, 19446, 4724, 1829, 9566, 1211, 3615, 5296, 31377, 2304, 7251, 5016, 35457, 2423, 2736, 9154, 8032, 18513, 4032, 2423, 2736, 9154, 8032, 18513, 4032, 4724, 1829, 25957, 1211, 9660, 1296, 552, 11933, 15730, 25961, 2423, 2736, 9154, 2423, 3366, 712, 5551, 5172, 11242, 1211, 6156, 10721, 8315, 4724, 32887, 5016, 15844, 2423, 3366, 712, 498, 264, 2736, 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{"start": 2199.92, "end": 2200.38, "word": " and", "probability": 0.97021484375}, {"start": 2200.38, "end": 2200.9, "word": " stocks", "probability": 0.841796875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2202.227, "duration_after_vad": 2117.396249999994} \ No newline at end of file diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..e59682e09a0f9adfacc35572237efb267c10ab74 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/wC9PsqvIyOw_raw.srt @@ -0,0 +1,1960 @@ +1 +00:00:21,240 --> 00:00:24,920 +we talk about the bond pricing المرة الأولى حكينا + +2 +00:00:24,920 --> 00:00:29,140 +عن bond pricing يعني كيف يتساعر السندات and how + +3 +00:00:29,140 --> 00:00:33,440 +the united states particularly the Wall Street + +4 +00:00:33,440 --> 00:00:38,120 +Journal how they price the bonds particularly the + +5 +00:00:38,120 --> 00:00:41,510 +treasury notes and treasury bondstoday I'm going + +6 +00:00:41,510 --> 00:00:45,170 +to talk in details about the bond markets يعني + +7 +00:00:45,170 --> 00:00:47,650 +اليوم هنحكي بتفاصيل ال bond market أسواق السندات + +8 +00:00:47,650 --> 00:00:50,950 +and to talk about the stock market as well و هنحكي + +9 +00:00:50,950 --> 00:00:54,250 +أيضا عن أسواق الأسهم I think this is very simple + +10 +00:00:54,250 --> 00:01:00,210 +you don't have complicated things in understanding + +11 +00:01:00,210 --> 00:01:03,130 +the bond market يعني مش هيكون عندنا الوضع صعب في + +12 +00:01:03,130 --> 00:01:07,410 +ال bond market so today I'm focusing on the bond + +13 +00:01:07,410 --> 00:01:11,450 +market in detailsand the stock market in details + +14 +00:01:11,450 --> 00:01:15,430 +fine just to remind you I talk about the main + +15 +00:01:15,430 --> 00:01:18,630 +difference between treasury notes and bonds حكينا + +16 +00:01:18,630 --> 00:01:21,570 +الفرق بين ال treasury notes و ال treasury bonds + +17 +00:01:21,570 --> 00:01:24,710 +التنين يتم إصدارهم من قبل ال government من قبل + +18 +00:01:24,710 --> 00:01:29,570 +الحكومة the treasury notes is equal or less than + +19 +00:01:29,570 --> 00:01:34,210 +10 years however the treasury bonds is greater + +20 +00:01:34,210 --> 00:01:40,350 +than 10 years to 30 yearsأesterday I logged in to + +21 +00:01:40,350 --> 00:01:43,630 +the Wall Street Journal and I found some bonds + +22 +00:01:43,630 --> 00:01:49,270 +issued or the maturity dates of some bonds up to + +23 +00:01:49,270 --> 00:01:54,930 +43 the day before it was 42 today yesterday I + +24 +00:01:54,930 --> 00:01:58,630 +showed some bonds the maturity dates of these + +25 +00:01:58,630 --> 00:02:03,250 +bonds up to 43I think in your free time is fine to + +26 +00:02:03,250 --> 00:02:09,990 +login the www.wsj.com in order to gain some + +27 +00:02:09,990 --> 00:02:13,330 +practical experience on how the different market + +28 +00:02:13,330 --> 00:02:16,330 +pricing they bond حتى ان انتوا تشوفوا من ناحية + +29 +00:02:16,330 --> 00:02:19,630 +العملية كيف الأسواق المالية بتعمل تسعير لأسواق + +30 +00:02:19,630 --> 00:02:24,680 +السنداتinflation protected treasury bonds these + +31 +00:02:24,680 --> 00:02:28,440 +bonds are issued to fight against the inflation + +32 +00:02:28,440 --> 00:02:32,180 +يعني هذه النوعية من السندات يتم إصدارها حتى تواجه + +33 +00:02:32,180 --> 00:02:36,580 +التدخم I don't want to focus on this type of bonds + +34 +00:02:36,580 --> 00:02:39,540 +أنا مش هركز على هذه أنواع السندات because this is + +35 +00:02:39,540 --> 00:02:43,380 +issued for a particular purposes مش هركز على هذا + +36 +00:02:43,380 --> 00:02:48,100 +النوع من السنداتلأنه هيكون التركيز على treasury + +37 +00:02:48,100 --> 00:02:50,380 +notes and bonds و على ال corporate bonds هذا + +38 +00:02:50,380 --> 00:02:54,480 +التركيز بتاعنا federal agency debts the same thing + +39 +00:02:54,480 --> 00:02:56,660 +I don't want to focus on this مش هركز على + +40 +00:02:56,660 --> 00:03:03,000 +international bonds international bonds هي .. هي + +41 +00:03:03,000 --> 00:03:07,120 +سندات دوليةحيث ال international bonds هم سندات + +42 +00:03:07,120 --> 00:03:12,740 +دولية يتم إصدارهم على مستوى دولي so it is marketed + +43 +00:03:12,740 --> 00:03:17,300 +in international markets so any company of the + +44 +00:03:17,300 --> 00:03:20,440 +United States أي شركة خارج الولايات المتحدة + +45 +00:03:20,440 --> 00:03:24,540 +الأمريكية ممكن تشتري هذا السند for instance we + +46 +00:03:24,540 --> 00:03:30,980 +have Yankee bondsand we have the .. the yen euro + +47 +00:03:30,980 --> 00:03:34,640 +bonds these bonds are traded internationally يعني + +48 +00:03:34,640 --> 00:03:39,040 +في مثلا عندنا سندات أصدرها اليابان شركات يابانية + +49 +00:03:39,040 --> 00:03:41,960 +مثلا بالدولار فبتم التداول فيها بال .. بالسوق + +50 +00:03:41,960 --> 00:03:46,000 +الدولي في شركات أمريكية كمان تقوم بإصدار سندات + +51 +00:03:46,000 --> 00:03:48,590 +خارج الولايات المتحدة الأمريكيةو هذا حكينا فيها + +52 +00:03:48,590 --> 00:03:51,390 +اسمها ال euro dollar bonds اللي هو ال euro dollar + +53 +00:03:51,390 --> 00:03:55,150 +bonds هدول بيصير فيهم traded off the united states + +54 +00:03:55,150 --> 00:03:59,270 +و هدول بتسميهم كمان international bonds ففي سندات + +55 +00:03:59,270 --> 00:04:05,450 +يتم إصدارها للتداول في مستوى العالم I talk about + +56 +00:04:05,450 --> 00:04:08,930 +municipal bonds اللي هو سندات البلديات and I + +57 +00:04:08,930 --> 00:04:12,110 +mentioned for two types of bonds حكينا على نوعين + +58 +00:04:12,110 --> 00:04:17,820 +من ال bonds the revenue bondsand general + +59 +00:04:17,820 --> 00:04:23,680 +obligations bonds the general obligation bonds as + +60 +00:04:23,680 --> 00:04:29,800 +you see here the + +61 +00:04:29,800 --> 00:04:33,220 +municipal bonds the types of bonds general + +62 +00:04:33,220 --> 00:04:37,960 +obligations bonds okay and this is this general + +63 +00:04:37,960 --> 00:04:42,320 +obligations bondsgeneral obligation bonds, this .. + +64 +00:04:42,320 --> 00:04:44,860 +this bond .. I will go back to the .. to the + +65 +00:04:44,860 --> 00:04:47,540 +previous slides just to focus on the type now + +66 +00:04:47,540 --> 00:04:52,340 +general obligations bonds هاي بتكون التزامات على + +67 +00:04:52,340 --> 00:04:55,720 +البلديات أو ال local governments الحكومة المحلية + +68 +00:04:56,460 --> 00:05:01,320 +and these bonds is paying back by using taxation + +69 +00:05:01,320 --> 00:05:04,660 +يتم تسديدها من خلال ال taxation من خلال الضريبة as + +70 +00:05:04,660 --> 00:05:07,460 +as you see here backed by taxing power of issuer + +71 +00:05:07,460 --> 00:05:12,360 +يعني البلدية نفسها بتسد قيمة السندات هذه من خلال + +72 +00:05:12,360 --> 00:05:17,030 +من خلال من خلال الضريبةOkay the second .. the + +73 +00:05:17,030 --> 00:05:18,930 +second one which is more important than the + +74 +00:05:18,930 --> 00:05:22,750 +previous one التاني وهو أهم من الأول بيسموها ال + +75 +00:05:22,750 --> 00:05:26,890 +revenue bonds ال revenue bonds هاي سندات إيرادية + +76 +00:05:26,890 --> 00:05:32,610 +موجودين + +77 +00:05:32,610 --> 00:05:39,030 +في page 36 لأ + +78 +00:05:39,030 --> 00:05:41,650 +اننا نحكي في تفاصيل هلأ تفاصيل + +79 +00:05:43,940 --> 00:05:48,820 +I will go back to them هرجعهم okay فال revenue + +80 +00:05:48,820 --> 00:05:55,360 +bonds backed by projects revenues يعني هي مدعومة + +81 +00:05:55,360 --> 00:05:59,260 +من الإيرادات بتاعة المشروع واللي هنحكي إيش + +82 +00:05:59,260 --> 00:06:02,340 +المشاريع اللي بيقوموا فيها or by the municipal + +83 +00:06:02,340 --> 00:06:06,320 +agency operating the projects هلأ الحكومة بتصدر + +84 +00:06:06,320 --> 00:06:10,040 +نوع من السندات اسمه ال revenue bonds اللي هو + +85 +00:06:10,040 --> 00:06:12,880 +السندات الإيرادية مثلا بروحوا بيفت بيعملوا مواد + +86 +00:06:12,880 --> 00:06:17,450 +جديدةفجزء من إيرادات الموانق بتروح للبلدية و + +87 +00:06:17,450 --> 00:06:21,850 +البلدية بتروح بت .. بتسد ال .. بتسد ال bonds .. + +88 +00:06:21,850 --> 00:06:26,470 +السندات مثلا هم بيعملوا طرق ال highways ال + +89 +00:06:26,470 --> 00:06:31,010 +highways و ال motorways اللي هو الطرق السريعة فجزء + +90 +00:06:31,010 --> 00:06:33,950 +من إيرادات الطرق السريعة مثلا الحكومة بتاخد ضريبة + +91 +00:06:33,950 --> 00:06:38,020 +على الطرقفجزء من الضريبة هاي بتروح لمين؟ بتروح لل + +92 +00:06:38,020 --> 00:06:42,820 +.. لل municipal للبلديات وبت .. تالى البلديات بي + +93 +00:06:42,820 --> 00:06:48,460 +.. بيسددوا الضريبة .. بيسددوا قيمة السندات كمان + +94 +00:06:48,460 --> 00:06:54,180 +إذا كانت مثلا الحكومة أو البلدية بتعمل مطارات عشان + +95 +00:06:54,180 --> 00:06:57,880 +تخلي الشركات تعمل .. تعمل investment في هذه + +96 +00:06:57,880 --> 00:07:01,580 +المطارات فجزء من إيرادات المطارات بتروح برضه لسداد + +97 +00:07:01,580 --> 00:07:06,030 +ال .. ال municipal أو بيسموها ال revenue bondsفهذا + +98 +00:07:06,030 --> 00:07:10,410 +يعني .. يعني كتمويل ل ال infrastructure المونية + +99 +00:07:10,410 --> 00:07:14,390 +بتاعتها في الدولة okay بالبلدية بتقوم إصدار سندات + +100 +00:07:14,390 --> 00:07:18,450 +حتى تستطيع تمول هاي المشاريع الكبيرة okay فبنسميها + +101 +00:07:18,450 --> 00:07:25,550 +ال revenue bonds لو رجعنا احنا شوية على ال .. ال + +102 +00:07:25,550 --> 00:07:29,800 +treasury notes and bondsحكينا ال municipal bonds و + +103 +00:07:29,800 --> 00:07:33,340 +the bond markets حكينا احنا بالأول ان في عندنا + +104 +00:07:33,340 --> 00:07:35,640 +municipal bonds و في عندنا corporate bonds و عندنا + +105 +00:07:35,640 --> 00:07:39,480 +الموردجاج just to remind you خليني بس اذاكركم ب .. + +106 +00:07:39,480 --> 00:07:42,380 +the big picture of the market bonds خليني اذاكركم + +107 +00:07:42,380 --> 00:07:48,240 +بال .. بالأسواق السنداتي بشكل عام حكينا ال bond + +108 +00:07:48,240 --> 00:07:53,220 +markets okay حكينا in generally we have two types + +109 +00:07:53,220 --> 00:07:58,350 +of bond markets اللي هو governmental bondsو + +110 +00:07:58,350 --> 00:08:02,170 +corporate bonds the + +111 +00:08:02,170 --> 00:08:06,350 +governments bonds issued by the governments or + +112 +00:08:06,350 --> 00:08:09,630 +local governments يعني من ال governments or local + +113 +00:08:09,630 --> 00:08:11,810 +governments ال local governments such as + +114 +00:08:11,810 --> 00:08:16,010 +municipals اللي هو البلديات ال government bonds + +115 +00:08:16,010 --> 00:08:23,110 +عندنا اللي هو the treasury notes and treasury + +116 +00:08:23,110 --> 00:08:26,590 +bonds and we have here the municipal + +117 +00:08:29,540 --> 00:08:34,560 +the municipal bonds includes two main bonds the + +118 +00:08:34,560 --> 00:08:39,760 +general obligation bonds and + +119 +00:08:39,760 --> 00:08:44,680 +revenue bonds and there is another type of bonds + +120 +00:08:44,680 --> 00:08:47,780 +called the industrial bonds this industrial bonds + +121 +00:08:47,780 --> 00:08:51,800 +is considered as one part of the revenue bonds + +122 +00:08:51,800 --> 00:08:55,300 +يعني هو نوع من أنواع ال revenue bonds اللي هو + +123 +00:08:55,300 --> 00:08:58,360 +industrial bonds industrial bond اللي هو سندات + +124 +00:08:58,360 --> 00:09:06,120 +صناعيةبنسميها industrial bonds يعني + +125 +00:09:06,120 --> 00:09:12,500 +.. يعني مثلا الحكومة بدها تعمل مناطق صناعية فعشان + +126 +00:09:12,500 --> 00:09:17,320 +يتشجع الصناعة في البلد okay فبروح بصدره industrial + +127 +00:09:17,320 --> 00:09:21,420 +bondsطبعا من وين بتصد ال industrial bond؟ هذا بتصد + +128 +00:09:21,420 --> 00:09:24,500 +من الصناعة اللي هتنشأ في ال .. في هذه المناطق + +129 +00:09:24,500 --> 00:09:28,040 +الصناعية فبيقوموا بيصدوا الإيرادات بتاعتهم في ال + +130 +00:09:28,040 --> 00:09:31,380 +corporate bonds اللي هنأيجي نحكي فيه بقى .. كمان + +131 +00:09:31,380 --> 00:09:39,060 +شوية اللي هو فيه عندنا secured bonds secured okay + +132 +00:09:39,060 --> 00:09:42,440 +secured bond يعني احنا لو نحكي عن ال corporate + +133 +00:09:42,440 --> 00:09:46,320 +bonds اللي هو السندات الشركات في عندنا نوعينالنوع + +134 +00:09:46,320 --> 00:09:51,340 +اسمه secured bond اللي هو سندات آمنة اسمها secured + +135 +00:09:51,340 --> 00:09:59,940 +bond وفي عندنا non secured bond سندات غير آمنة و + +136 +00:09:59,940 --> 00:10:03,550 +إيش الفرق بين ال secured و ال non secured؟ال + +137 +00:10:03,550 --> 00:10:08,030 +secured سندات آمنة يعني انه is the company which + +138 +00:10:08,030 --> 00:10:11,730 +issued this part of bonds has a good historical + +139 +00:10:11,730 --> 00:10:15,650 +profile يعني الشركة اللي أصدرت هذا النوع من السند + +140 +00:10:15,650 --> 00:10:20,290 +الآمن لها good profile يعني سمعتها كويسة و عندها + +141 +00:10:20,290 --> 00:10:23,650 +أرباح منيحة و عندها سمعة طيبة however the non + +142 +00:10:23,650 --> 00:10:28,390 +secured bondالسندات الغير أمنة non secured bond + +143 +00:10:28,390 --> 00:10:31,490 +بيكون الشركة اللي أصدرت هذه النوع من السندات شركة + +144 +00:10:31,490 --> 00:10:35,830 +ضعيفة وماعنداش سمعة إمنيها فبيسموها non secured + +145 +00:10:35,830 --> 00:10:36,510 +bond + +146 +00:10:40,070 --> 00:10:46,570 +again للناس اللي يعني إيجوا متأخرين the bond + +147 +00:10:46,570 --> 00:10:50,690 +market is classified into two main parts the first + +148 +00:10:50,690 --> 00:10:52,990 +one the government and the second one is the + +149 +00:10:52,990 --> 00:10:57,950 +corporate the government is divided for three main + +150 +00:10:57,950 --> 00:11:01,350 +types the municipal, the treasury bonds and the + +151 +00:11:01,350 --> 00:11:04,890 +treasury notes the municipal is divided for two + +152 +00:11:04,890 --> 00:11:08,890 +main parts revenue bonds and the general + +153 +00:11:08,890 --> 00:11:17,320 +obligation oneOkay the corporate bond this + +154 +00:11:17,320 --> 00:11:22,200 +is municipal okay this is treasury bond this is + +155 +00:11:22,200 --> 00:11:26,160 +treasury notes municipal اللي هو البلديات treasury + +156 +00:11:26,160 --> 00:11:30,740 +bonds اللي هو سندات الحكومة هي سندات الحكومة لكن + +157 +00:11:30,740 --> 00:11:34,300 +بنسميها notes okay I explained this before + +158 +00:11:35,630 --> 00:11:38,970 +municipal bonds divided for two main types بتتقسم + +159 +00:11:38,970 --> 00:11:41,930 +لخصمين ال revenue اللي هو الإيرادية والتانية اللي + +160 +00:11:41,930 --> 00:11:44,570 +هو general obligations اللي هي التزامات على + +161 +00:11:44,570 --> 00:11:48,070 +البلدية نفسها ال revenue في نوع واحد من ال revenue + +162 +00:11:48,070 --> 00:11:50,770 +اللي هو بيسميه industrial اللي هو الصناعي اللي هو + +163 +00:11:50,770 --> 00:11:53,950 +سندات صناعية ال corporate bonds اللي هو سندات + +164 +00:11:53,950 --> 00:11:57,010 +الشركات بتصدرها الشركات we have two main types + +165 +00:11:57,010 --> 00:11:59,610 +اللي هو عندنا secured bond وفي عندنا non secured + +166 +00:11:59,610 --> 00:12:05,320 +bond اللي هو سندات أمنةالغير أمينة ملاحظة بسيطة في + +167 +00:12:05,320 --> 00:12:11,520 +ال corporate bonds اللي هو سندات الشركات في عندنا + +168 +00:12:11,520 --> 00:12:15,820 +كتير أنواع لكن احنا for the limits of this level + +169 +00:12:15,820 --> 00:12:18,160 +عشان هذا المستوى من الطلاب because this is + +170 +00:12:18,160 --> 00:12:20,600 +introduction to investments لأن هي مقدمة بال + +171 +00:12:20,600 --> 00:12:23,480 +investments I don't want to go in details about + +172 +00:12:23,480 --> 00:12:27,080 +the different types of the bonds يعني أنا مش راح + +173 +00:12:27,080 --> 00:12:32,210 +أروح كتير تفاصيل بال bonds بأنواعهالأنه you are in + +174 +00:12:32,210 --> 00:12:34,510 +the introduction of investment انتوا عندكوا بس + +175 +00:12:34,510 --> 00:12:38,230 +مقدمة الاستثمار يعني لما تقرأوا في كتب أخرى عن ال + +176 +00:12:38,230 --> 00:12:42,310 +bonds you will find for instance junk bonds يعني + +177 +00:12:42,310 --> 00:12:46,230 +هنشوف ال junk bonds فال junk bonds هذا هو نوع من + +178 +00:12:46,230 --> 00:12:50,190 +أنواع ال non secured bond فمش هنحكي فيه لأنه هذا + +179 +00:12:50,190 --> 00:12:54,490 +شوي متقدم في ال investments municipal + +180 +00:13:01,070 --> 00:13:04,110 +لأنه هي من ال local governments بتنشئها، هي + +181 +00:13:04,110 --> 00:13:07,290 +بتنشئها ال local governments ال municipal هي أصلا + +182 +00:13:07,290 --> 00:13:10,350 +بتنشئها الحكومة فعشان هيك احنا قاعدين under the + +183 +00:13:10,350 --> 00:13:13,990 +governments بس issued by the local governments + +184 +00:13:13,990 --> 00:13:14,710 +okay + +185 +00:13:17,490 --> 00:13:20,950 +طيب، so we talk about municipal bonds, we talk + +186 +00:13:20,950 --> 00:13:24,470 +about corporate bonds and this mortgage and + +187 +00:13:24,470 --> 00:13:26,730 +mortgage-backed bonds I don't want to focus on + +188 +00:13:26,730 --> 00:13:29,450 +this because only the United States they issue + +189 +00:13:29,450 --> 00:13:34,500 +this particular bonds and the UK sometimesI talk + +190 +00:13:34,500 --> 00:13:38,340 +about the maturities about the treasury notes حكيت + +191 +00:13:38,340 --> 00:13:42,520 +عنه أصلا and I mention for the bar value of the + +192 +00:13:42,520 --> 00:13:46,140 +treasury notes and bonds is one thousand so don't + +193 +00:13:46,140 --> 00:13:50,760 +mix up between the treasury bills and treasury + +194 +00:13:50,760 --> 00:13:54,240 +notes the treasury bills bar value is ten thousand + +195 +00:13:54,240 --> 00:13:58,580 +and the bar value of the treasury notes is one + +196 +00:13:58,580 --> 00:14:01,960 +thousandOkay بدناش نعمل خلط بين treasury notes و + +197 +00:14:01,960 --> 00:14:06,340 +treasury bills Interest paid semi-annually حكينا + +198 +00:14:06,340 --> 00:14:10,920 +أنه بتدفع نصف سنوية وورجيناكوا مثلا المرة الفاتة + +199 +00:14:10,920 --> 00:14:14,900 +how we calculate this you just divide C by 2 نقسم + +200 +00:14:14,900 --> 00:14:17,360 +ال coupon rates على اتنين بتطلع مننا ال semi + +201 +00:14:17,360 --> 00:14:20,920 +-annual Quarters percentage of bar وورجيناكوا كيف + +202 +00:14:20,920 --> 00:14:24,880 +how we pricing them كيف نعمل تسعير and how we + +203 +00:14:24,880 --> 00:14:30,710 +drive the pricing system okay in your examفي + +204 +00:14:30,710 --> 00:14:35,870 +الامتحان بتاعكم حاطيكم tableهذا ال table جاي من ال + +205 +00:14:35,870 --> 00:14:40,690 +.. جاي من ال .. ال wsj.com بدي أجيبه من ال Wall + +206 +00:14:40,690 --> 00:14:44,370 +Street Journal و أقولكم please convert this table + +207 +00:14:44,370 --> 00:14:47,250 +into the pricing system حاولوا ليها الأسعار ال + +208 +00:14:47,250 --> 00:14:51,350 +pricing system يعني كلامي واضح بجيبكم table based + +209 +00:14:51,350 --> 00:14:54,650 +on the percentage as .. as this as in the + +210 +00:14:54,650 --> 00:14:57,770 +percentage of .. of the bar value then convert it + +211 +00:14:57,770 --> 00:15:00,990 +into the pricing system and I showed you how to do + +212 +00:15:00,990 --> 00:15:05,680 +this و أرجيتكم المرة الفاتتة how we do thisOkay if + +213 +00:15:05,680 --> 00:15:09,100 +you don't understand go back to the videos okay + +214 +00:15:09,100 --> 00:15:20,540 +and you will have the calculations okay + +215 +00:15:20,540 --> 00:15:26,300 +the ask yield if you want to the ask yield is + +216 +00:15:26,300 --> 00:15:31,880 +equal the coupon rates you can write down the + +217 +00:15:31,880 --> 00:15:40,380 +equation for ask yieldask yield is equal the + +218 +00:15:40,380 --> 00:15:50,540 +coupon divided by the ask price ال coupon اختيه ال + +219 +00:15:50,540 --> 00:15:56,080 +coupon من يومين احنا بنحكي في ال coupon الفائدة و + +220 +00:15:56,080 --> 00:15:59,420 +ال ask price اللي هو سعر الشراء for the investors + +221 +00:15:59,420 --> 00:16:04,040 +that's itOkay رجاء ال .. ال .. الاشي اللي بتاخدوه + +222 +00:16:04,040 --> 00:16:07,600 +يعني رجعوله لأنه خلاص أنا بحكيت ال ask and already + +223 +00:16:07,600 --> 00:16:10,220 +you know what it means ask و لما حكيت ال coupon I + +224 +00:16:10,220 --> 00:16:13,560 +don't need to go back on .. on .. ال coupon معروف + +225 +00:16:13,560 --> 00:16:18,080 +ال coupon okay و + +226 +00:16:18,080 --> 00:16:21,380 +أرجعتكم كيف تعمل login لهم okay هلأ المطلوب منكم + +227 +00:16:21,380 --> 00:16:24,360 +أنه to convert this table into the pricing system + +228 +00:16:24,360 --> 00:16:27,480 +that's it مطلوب منكم تعملوا ال pricing system + +229 +00:16:31,830 --> 00:16:35,590 +Okay so the bond markets as as I told you for the + +230 +00:16:35,590 --> 00:16:38,450 +inflation protected federal agency bonds just only + +231 +00:16:38,450 --> 00:16:41,490 +the international bonds we are talking about + +232 +00:16:41,490 --> 00:16:47,850 +listen here we have in the international bonds أنا + +233 +00:16:47,850 --> 00:16:51,490 +حكيت قبل شوية بال international bonds حكيت عن ال + +234 +00:16:51,490 --> 00:16:56,790 +euro bonds و ال yankee bonds ال euro bonds is bond + +235 +00:16:56,790 --> 00:17:04,070 +issued of the united statesيعني هي سندات تصدر خارج + +236 +00:17:04,070 --> 00:17:06,990 +المولايات المتحدة الأمريكية in the dollar amount + +237 +00:17:06,990 --> 00:17:12,330 +بقيمة الدولار and .. and I explain why some + +238 +00:17:12,330 --> 00:17:18,410 +institutions issued bonds or dollar bonds of the + +239 +00:17:18,410 --> 00:17:21,410 +United States لأنه ت escape .. ت escape from the + +240 +00:17:21,410 --> 00:17:24,170 +regulations of the Federal Reserve Bankيعني عشان + +241 +00:17:24,170 --> 00:17:27,650 +يخرجوا من سيطرة ال .. البنك الفيدرالي الأمريكي و + +242 +00:17:27,650 --> 00:17:31,010 +بتكون زي ما اتفضلتها انه ال .. ال .. الإيراد او ال + +243 +00:17:31,010 --> 00:17:34,010 +return عالي كتير في مقارنة مع inside the united + +244 +00:17:34,010 --> 00:17:38,050 +states ال yankee bonds which is the opposite of + +245 +00:17:38,050 --> 00:17:42,050 +euro bonds عكسه تمام it means non united states + +246 +00:17:42,050 --> 00:17:46,070 +bonds in the united states تبقى is non united + +247 +00:17:46,070 --> 00:17:51,570 +states companies in the united statesissued dollar + +248 +00:17:51,570 --> 00:17:56,430 +bonds يعني بتكون شركات ليست أمريكية يعني ممكن + +249 +00:17:56,430 --> 00:17:58,790 +شركات صينية تكون داخل الولايات المتحدة الأمريكية + +250 +00:17:58,790 --> 00:18:03,130 +تصدر bond بالدولار فهي بيسميها ايش؟ بيسميها Yankee + +251 +00:18:03,130 --> 00:18:07,730 +bonds طبعا Yankee هي .. is a terminology is used + +252 +00:18:07,730 --> 00:18:11,270 +by the .. by the financial market هي عبارة عن + +253 +00:18:11,270 --> 00:18:17,570 +مصطلح جاي .. هو تقريبا جاي من هنا جاي انهأي شركة + +254 +00:18:17,570 --> 00:18:22,150 +.. بنعطيكوا مثال مثلا .. مثلا نحكي شركة rem عارفين + +255 +00:18:22,150 --> 00:18:28,230 +شركة rem؟ rim .. rim .. يضلوا rim .. okay شركة rim + +256 +00:18:28,230 --> 00:18:30,550 +producing the blackberry + +257 +00:18:33,220 --> 00:18:38,080 +Rim is producing the which is non united states + +258 +00:18:38,080 --> 00:18:43,180 +company if rim issued bonds inside united states + +259 +00:18:43,180 --> 00:18:46,340 +this bond considered as a Yankee bond يعني إذا + +260 +00:18:46,340 --> 00:18:50,320 +كانت ريم أصدرت سنة داخل ولاية المتحدة الأمريكية + +261 +00:18:50,320 --> 00:18:55,980 +بيسمياش Yankee bondOkay another example if you + +262 +00:18:55,980 --> 00:19:01,760 +talk about Nestle عارفين شركة Nestle؟ Okay هاي إيش + +263 +00:19:01,760 --> 00:19:05,600 +أصلها Nestle؟ طبعا الملكية تبعتها اتغيرت مرة + +264 +00:19:05,600 --> 00:19:11,720 +فرنسية .. أخر إشي كانت الملكية تبعتها و if .. if + +265 +00:19:11,720 --> 00:19:15,080 +this company إذا هذه الشركة أصدرت bond inside the + +266 +00:19:15,080 --> 00:19:19,540 +United States هذا ال bond بنسميه Yankee bond فواضح + +267 +00:19:19,540 --> 00:19:22,360 +انكم what it means Yankee bond okay + +268 +00:19:24,540 --> 00:19:30,380 +and I talk about the municipal bonds the main + +269 +00:19:30,380 --> 00:19:35,120 +characteristics of the municipal bonds واحدة من + +270 +00:19:35,120 --> 00:19:39,620 +الخصائص سبعة ال municipal bonds is tax exempted + +271 +00:19:39,620 --> 00:19:44,820 +what it means tax exempted it means أن السند اللي + +272 +00:19:44,820 --> 00:19:48,540 +بتصدره البلدية هو خالي من الضريبة أو معفي من + +273 +00:19:48,540 --> 00:19:52,950 +الضريبةis tax exempted خالي من الدريبة so the + +274 +00:19:52,950 --> 00:19:58,150 +investors are comparing between the bond with a + +275 +00:19:58,150 --> 00:20:02,050 +tax and the bond is tax exempted يعني المستثمرين + +276 +00:20:02,050 --> 00:20:05,950 +يقارنوا بين نوعين من السندات السند اللي عليه دريبة + +277 +00:20:05,950 --> 00:20:08,750 +والسند اللي معه فيه بالدريبةيعني أي investors بدهم + +278 +00:20:08,750 --> 00:20:12,550 +يعمل قرار استثمار بيقارنه بين two different types + +279 +00:20:12,550 --> 00:20:16,250 +of bonds بيقارنه نوعين من ال bonds السند اللي عليه + +280 +00:20:16,250 --> 00:20:18,730 +ضريبة و السند اللي معاه فيه من الضريبة how they do + +281 +00:20:18,730 --> 00:20:21,610 +this كيف بيعملوا كلام هذا I will show you how they + +282 +00:20:21,610 --> 00:20:24,830 +do this كيف هم بيعملوا conversion between the + +283 +00:20:24,830 --> 00:20:28,350 +taxable bonds and non-taxable bonds or tax + +284 +00:20:28,350 --> 00:20:33,180 +exempted bondsOkay and this is a question in your + +285 +00:20:33,180 --> 00:20:36,320 +exam و هذا كمان سؤال هجيبكوا في الامتحان أنه how + +286 +00:20:36,320 --> 00:20:39,160 +investors compare between the taxable bonds and + +287 +00:20:39,160 --> 00:20:44,860 +the tax exempted bonds I will show you how يعني + +288 +00:20:44,860 --> 00:20:50,520 +كيف المستثمرين بيفرقوا أو بيتخذوا قرار استثمار + +289 +00:20:50,520 --> 00:20:56,900 +بناء على الدريبة فهم بيقارنوا بين إذا أنا مستثمرو + +290 +00:20:56,900 --> 00:21:01,420 +أمامي two bonds أمامي سندين سند عليه ضريبة وسند ما + +291 +00:21:01,420 --> 00:21:05,980 +.. مافيه من الضريبة أنه أفضل أستثمر هذا ولا هذا so + +292 +00:21:05,980 --> 00:21:09,480 +we cannot say yes or no unless we do some + +293 +00:21:09,480 --> 00:21:13,880 +calculations يعني مابنقدرش نقول yes or no بدون ما + +294 +00:21:13,880 --> 00:21:16,660 +نعمل some calculations I will show you how we can + +295 +00:21:16,660 --> 00:21:21,040 +do this we + +296 +00:21:21,040 --> 00:21:28,070 +cannot say this she said .. she saidthe one with + +297 +00:21:28,070 --> 00:21:33,690 +tax exempted is more preferable than the others we + +298 +00:21:33,690 --> 00:21:38,270 +cannot say this so we compare between the two + +299 +00:21:38,270 --> 00:21:42,670 +bonds with taxable and with tax exempted هنقارن + +300 +00:21:42,670 --> 00:21:47,350 +بين الاتنين how we can do this I will show you how + +301 +00:21:47,350 --> 00:21:50,830 +we can do this هنشوفكم .. هنشوف كيف نعمل الكلام + +302 +00:21:50,830 --> 00:21:57,230 +هذاطيب هلو لو احنا اعطينا رمز لل taxable bonds .. + +303 +00:21:57,230 --> 00:22:03,310 +non-taxable bonds RM + +304 +00:22:03,310 --> 00:22:06,930 +RM + +305 +00:22:06,930 --> 00:22:11,470 +is stand for municipal bonds يعني العائد على السند + +306 +00:22:11,470 --> 00:22:15,630 +اللي بتصدر البلدية and as we agree واتفقنا مع بعض + +307 +00:22:15,630 --> 00:22:19,570 +the municipal bond is tax exemptedيعني اتفقنا مع + +308 +00:22:19,570 --> 00:22:22,770 +بعض أنه السندات اللي بتصدرها البلدية ما فيها من + +309 +00:22:22,770 --> 00:22:26,950 +الدريبة so the return of M is to stand for the + +310 +00:22:26,950 --> 00:22:32,250 +municipal bonds if tax exempted if this equal X + +311 +00:22:32,250 --> 00:22:35,650 +for instance X is a number or the rate of return + +312 +00:22:35,650 --> 00:22:43,080 +and R is the taxable bondsSo again RM is tax free + +313 +00:22:43,080 --> 00:22:48,220 +يعني ماعلوش ضريبة و R هو عليه ضريبة and we compare + +314 +00:22:48,220 --> 00:22:54,760 +between two of them but this is because this has a + +315 +00:22:54,760 --> 00:22:58,120 +taxation so we have to pay tax so we deduct tax + +316 +00:22:58,120 --> 00:23:02,020 +from this لازم نختم منه ضريبة صح؟ So deducted tax + +317 +00:23:02,020 --> 00:23:08,930 +is one minus Tone minus T T is stand for taxation + +318 +00:23:08,930 --> 00:23:20,710 +يعني T تربز إلى الدريبة T if R الدريبة T stand for + +319 +00:23:20,710 --> 00:23:26,890 +taxation T tax R is the rate of return of the + +320 +00:23:26,890 --> 00:23:32,710 +municipal bondsOkay R is the taxable bonds السند + +321 +00:23:32,710 --> 00:23:36,050 +اللي عليه ضريبة So we are comparing between this + +322 +00:23:36,050 --> 00:23:40,310 +and this We are in other words احنا بنقارن بالسند + +323 +00:23:40,310 --> 00:23:42,550 +اللي عليه ضريبة في عائد السند اللي عليه ضريبة + +324 +00:23:42,550 --> 00:23:49,710 +وعائد السند اللي ماعفيه من الضريبة Okay So if this + +325 +00:23:49,710 --> 00:23:58,910 +equal Y it means if R is greater than RMإذا كان + +326 +00:23:58,910 --> 00:24:02,650 +العائد بتاع R، طبعا الـR هي إيش؟ العلي دريبة، + +327 +00:24:02,650 --> 00:24:10,250 +العلي دريبة is greater than RM, so we prefer R it + +328 +00:24:10,250 --> 00:24:17,230 +means we are not always keep our eyes in the + +329 +00:24:17,230 --> 00:24:20,670 +municipal bonds يعني مش دايما احنا we select + +330 +00:24:20,670 --> 00:24:24,310 +municipal bonds because it depends on the R after + +331 +00:24:24,310 --> 00:24:29,020 +taxلأنه بنحسب ال R after tax يعني قداش بعد الضريبة + +332 +00:24:29,020 --> 00:24:32,240 +and then after that we compare between them if R + +333 +00:24:32,240 --> 00:24:37,440 +is greater than RM so we go for R otherwise .. + +334 +00:24:37,440 --> 00:24:41,860 +otherwise يعني إذا ماكانش الكلام هذا we go for RM + +335 +00:24:41,860 --> 00:24:47,320 +يعني إذا كان العكس is the opposite if RM is + +336 +00:24:47,320 --> 00:24:53,580 +greater than RM we prefer RM this is very simple + +337 +00:24:56,470 --> 00:25:00,410 +which one okay + +338 +00:25:00,410 --> 00:25:05,930 +هلأ احنا هال R M ماعليهاش ضريبة صح و ال R اللي هي + +339 +00:25:05,930 --> 00:25:08,270 +اللي عليها ضريبة هيخلصنا منها الضريبة one one + +340 +00:25:08,270 --> 00:25:12,570 +minus tax T إذا كان الجواب let's say إذا كان + +341 +00:25:12,570 --> 00:25:17,710 +الجواب عندنا هان كان هان هان مثلا six percent okay + +342 +00:25:17,710 --> 00:25:23,790 +و هان كان after tax is seven percentSo in this + +343 +00:25:23,790 --> 00:25:30,410 +case R is greater than RM So we select R نختار ال + +344 +00:25:30,410 --> 00:25:34,490 +R Otherwise if this is wrong Otherwise إذا كان + +345 +00:25:34,490 --> 00:25:41,930 +العكس So RM is greater than R نختار ال R نختار ال + +346 +00:25:41,930 --> 00:25:48,610 +R نختار + +347 +00:25:48,610 --> 00:25:50,630 +ال R نختار ال R نختار ال R نختار ال R نختار ال R + +348 +00:25:50,630 --> 00:25:50,990 +نختار ال R نختار ال R نختار ال R نختار ال R نختار + +349 +00:25:50,990 --> 00:25:51,030 +ال R نختار ال R نختار ال R نختار ال R نختار ال R + +350 +00:25:51,030 --> 00:25:51,030 +نختار ال R نختار ال R نختار ال R نختار ال R نختار + +351 +00:25:51,030 --> 00:25:51,030 +ال R نختار ال R نختار ال R نختار ال R نختار ال R + +352 +00:25:51,030 --> 00:25:51,030 +نختار ال R نختار ال R نختار ال R نختار ال R نختار + +353 +00:25:51,030 --> 00:25:51,030 +ال R نختار ال R نختار ال R نختار ال R نختار ال R + +354 +00:25:51,030 --> 00:25:54,990 +نختار ال R نختار ال R نختار ال R نختارlet this is + +355 +00:25:54,990 --> 00:25:58,430 +the let T equal the investor margin tax so this is + +356 +00:25:58,430 --> 00:26:04,010 +T and I explain tax okay let R equal the before + +357 +00:26:04,010 --> 00:26:07,870 +tax return on the taxable bond اللي هو ال R شايفين + +358 +00:26:07,870 --> 00:26:11,030 +ال R this is before tax لما احنا بنضرب one minus T + +359 +00:26:11,030 --> 00:26:16,150 +بيصير after taxand RM اللي احنا شرحناها ال RM + +360 +00:26:16,150 --> 00:26:20,390 +شفتوها denote the municipal bonds اللي هي السند + +361 +00:26:20,390 --> 00:26:26,450 +بتاع البلدية وحكينا ال municipal bonds هو is tax + +362 +00:26:26,450 --> 00:26:32,780 +exemptedهو مافيه من الضريبة Why is tax exempted to + +363 +00:26:32,780 --> 00:26:36,900 +encourage investors to hold this bond؟ ليش البلدية + +364 +00:26:36,900 --> 00:26:40,440 +بتاع فيه من الضريبة عشان تشجع ال investors أنه + +365 +00:26:40,440 --> 00:26:44,560 +تحمل هذا النوع من السندات طبعا نفس ال calculation + +366 +00:26:44,560 --> 00:26:51,590 +if R1-Tgreater than RM then the taxable bond gives + +367 +00:26:51,590 --> 00:26:54,870 +a higher rate of return otherwise the municipal + +368 +00:26:54,870 --> 00:26:59,590 +bond is preferred زي ما أنا حكيته إذا كان R1-T + +369 +00:26:59,590 --> 00:27:03,310 +اللي شايفينها is greater than RM so in this case + +370 +00:27:03,310 --> 00:27:08,970 +we prefer the taxable bonds otherwise the tax + +371 +00:27:08,970 --> 00:27:13,910 +exempted bond is preferable okay how we calculate + +372 +00:27:13,910 --> 00:27:21,410 +theكيف ممكن نحسب اذا كان عندى انا سند one percent + +373 +00:27:21,410 --> 00:27:24,390 +اذا كان عندى one percent سند زى ما انتوا شايفين + +374 +00:27:24,390 --> 00:27:32,590 +هان سند one percent شايفين هذا ال one percent كيف + +375 +00:27:32,590 --> 00:27:39,070 +بدنا نعرف المقابله من السندات اللى عليها ضريبة سند + +376 +00:27:39,070 --> 00:27:45,560 +يعنى مثلا عندى سند مافيه من الضريبةبتعرف مقابل سند + +377 +00:27:45,560 --> 00:27:47,900 +عليه ضريبة، كده لازم يتساوي مع بعض، فبتسمي + +378 +00:27:47,900 --> 00:27:53,660 +equivalent يعني equivalent tax yield أنه متى ال .. + +379 +00:27:53,660 --> 00:27:57,840 +ال .. ال .. ال .. ال .. ال two interest rates are + +380 +00:27:57,840 --> 00:28:02,220 +equal متى بيكونوا التانية بتساوي مع بعض، لو كان + +381 +00:28:02,220 --> 00:28:05,680 +عندي واحد في المية، واحد في المية tax exempted، + +382 +00:28:05,680 --> 00:28:13,130 +ماعليهوش ضريبة equivalent yieldهي موجودة هي the + +383 +00:28:13,130 --> 00:28:17,150 +equivalent taxable yield ايش معناه when احنا we + +384 +00:28:17,150 --> 00:28:21,030 +are in difference اتطلعوا هان اتطلعوا على ال + +385 +00:28:21,030 --> 00:28:24,850 +equation هادى اتطلعوا كلكوا على ال equation هلا ال + +386 +00:28:24,850 --> 00:28:28,670 +equation هان اللي هو R after tax اذا احنا بنصلحها + +387 +00:28:28,670 --> 00:28:33,990 +هي one minus T okay is greater than RM and RM is + +388 +00:28:33,990 --> 00:28:40,280 +greater than R so my question is whenR 1 minus T + +389 +00:28:40,280 --> 00:28:48,080 +is equal RM R 1 minus T is equal R هذا لما يكونوا + +390 +00:28:48,080 --> 00:28:52,760 +تنامت سوين RM لما يكونوا تنامت سوين so the + +391 +00:28:52,760 --> 00:28:55,440 +investors are in difference ايش معناه in + +392 +00:28:55,440 --> 00:28:58,440 +difference يعني سواء أخدوا هذا ولا أخدوا هذا نفس + +393 +00:28:58,440 --> 00:29:06,520 +الشيء نفس الشيء okayنريد أن نعرف R1-T وهذا R بعد + +394 +00:29:06,520 --> 00:29:10,160 +التجارة للمعادلين المتجارين وهذا تجارب ممكن تجارب + +395 +00:29:10,160 --> 00:29:13,240 +تجارب تجارب تجارب + +396 +00:29:13,240 --> 00:29:13,780 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +397 +00:29:13,780 --> 00:29:14,100 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +398 +00:29:14,100 --> 00:29:14,600 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +399 +00:29:14,600 --> 00:29:16,240 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +400 +00:29:16,240 --> 00:29:17,780 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +401 +00:29:17,780 --> 00:29:23,780 +تجارب تجارب تج + +402 +00:29:24,310 --> 00:29:27,630 +interest or these yields one two three four + +403 +00:29:27,630 --> 00:29:31,050 +percent for the tax exempted هدول tax exempted we + +404 +00:29:31,050 --> 00:29:35,410 +want to know if you just hide all of these we want + +405 +00:29:35,410 --> 00:29:39,810 +to know what is the tax the equivalent rate for + +406 +00:29:39,810 --> 00:29:45,750 +the taxable one يعني بتشوف جداش العائد على ال + +407 +00:29:45,750 --> 00:29:48,890 +taxable على السند اللي عليه ضريبة جداش .. وين + +408 +00:29:48,890 --> 00:29:52,430 +بتساوىأنا بأعطيكوا الضريبة زي ما أنتوا شايفين + +409 +00:29:52,430 --> 00:29:57,410 +طلعواها ال marginal tax rate مرة أعطيناها 20% مرة + +410 +00:29:57,410 --> 00:30:03,090 +30% مرة 40 مرة 50 لأن مرات بتتغير الضريبة okay how + +411 +00:30:03,090 --> 00:30:08,370 +we calculate this you just follow the equation so + +412 +00:30:08,370 --> 00:30:14,730 +RM divided by 1 minus T يعني 1% تقسيم 1 minus T + +413 +00:30:14,730 --> 00:30:20,290 +اللي هو 20%خلّين إذا إنتوا حابين تتأكدوا إنه هاي + +414 +00:30:20,290 --> 00:30:23,830 +ال one point twenty five اللي شايفينها هان how we + +415 +00:30:23,830 --> 00:30:29,570 +get this one percent اللي هي ال tax exempted تقسيم + +416 +00:30:29,570 --> 00:30:34,530 +واحد minus اللي هي العشرين في المية twenty percent + +417 +00:30:35,410 --> 00:30:39,170 +بتطلع هذه how we can do the next البعديها كيف + +418 +00:30:39,170 --> 00:30:43,250 +هنسويها لأ the same الواحد في المية تقسيم واحد + +419 +00:30:43,250 --> 00:30:48,050 +minus 30 yes 30 percent and the rest و بتسوي + +420 +00:30:48,050 --> 00:30:52,430 +الكلام هذا كله طيب معناه الكلام بعد ما نخلص ال + +421 +00:30:52,430 --> 00:30:55,810 +table بعد + +422 +00:30:55,810 --> 00:31:00,890 +ما نخلص ال table it meansانتبهوا هان one point + +423 +00:31:00,890 --> 00:31:05,290 +twenty five percent taxable bond is equal one + +424 +00:31:05,290 --> 00:31:11,790 +percent tax exempted bond يعني لو احنا أخدنا سند + +425 +00:31:11,790 --> 00:31:16,010 +عليه ضريبة الواحد فاصلة اتنين فاصلة خمسة after tax + +426 +00:31:16,010 --> 00:31:22,930 +هيساوي واحد فلمية على سند معفي من الضريبة لو احنا + +427 +00:31:22,930 --> 00:31:28,670 +أخدنا هان كمانلو أخدنا مثلا هنا لعند 4% لعند 40% + +428 +00:31:28,670 --> 00:31:34,890 +الدريبة سند بيعطيني سند عليه دريبة 6.67% هو نفسه + +429 +00:31:34,890 --> 00:31:40,530 +هيساوي 4% إذا كان ماعفي من الدريبة لو أخدنا ال 10% + +430 +00:31:40,530 --> 00:31:46,550 +هذا المثال this bond is taxable bond هذا عليه + +431 +00:31:46,550 --> 00:31:51,670 +دريبة is equal 5% if it is tax exempted يعني 5% + +432 +00:31:51,670 --> 00:31:54,830 +بتسوى 10% في حالة إعفاء الدريبة + +433 +00:32:00,290 --> 00:32:08,950 +Okay؟ كيف؟ where أي واحدة؟ هذه؟ نفس الطريقة هذه + +434 +00:32:08,950 --> 00:32:12,510 +نفسي أنا بس ورجيتك واحدة تانية مش هورجيك الكل + +435 +00:32:12,510 --> 00:32:15,850 +طلعنا + +436 +00:32:15,850 --> 00:32:23,510 +ال equivalence طلعنا هذه ال T طلعنا أنه متى هذا + +437 +00:32:23,510 --> 00:32:27,170 +بيساوي هذاإيش ال rates بيكون مثلا أنا ال R مش + +438 +00:32:27,170 --> 00:32:33,130 +عارفها I don't know this R I know RM I know T so + +439 +00:32:33,130 --> 00:32:37,930 +only things I need this so in this case R is equal + +440 +00:32:37,930 --> 00:32:47,570 +من المعادلة RM divided by 1 minus T شو؟ + +441 +00:32:49,920 --> 00:32:53,580 +الواحد في اكتشاف اه هي tax exempted شايفها هي tax + +442 +00:32:53,580 --> 00:32:58,260 +exempted نرجع للمعادلة يا برات برات هذه very + +443 +00:32:58,260 --> 00:33:04,280 +simple mathematics mathematics بتاعة very simple + +444 +00:33:04,280 --> 00:33:08,980 +تبوا علينا شوفوا + +445 +00:33:08,980 --> 00:33:16,080 +رياضيا هلأ كان عندى Rone minus T should equal RM + +446 +00:33:16,080 --> 00:33:23,920 +مظبوط؟ زي ما علمونا في الرياضيات if I want R so R + +447 +00:33:23,920 --> 00:33:28,600 +is equal RM و هذه بتروح تحت هذه صح؟ one minus T + +448 +00:33:28,600 --> 00:33:35,160 +فأنا كأني بسأل what is the rate of taxable bond if + +449 +00:33:36,320 --> 00:33:41,460 +R is R after tax equal RM ففي الحالة هذه أنا مش + +450 +00:33:41,460 --> 00:33:45,640 +عارف ال R ف RM divided by 1 minus T فهذه + +451 +00:33:45,640 --> 00:33:48,020 +Mathematics أنا كنت أفكر أن أنت you know what it + +452 +00:33:48,020 --> 00:33:51,000 +means mathematically يعني أنا بفكر أن أنت بتعرف + +453 +00:33:51,000 --> 00:33:56,020 +Mathematically فأنا + +454 +00:33:56,020 --> 00:34:05,500 +مش عارف هذه I don't know this بالظبط كده this one + +455 +00:34:06,800 --> 00:34:10,740 +هيبقى انا .. انا هذا ال .. ال table هذا مش موجود + +456 +00:34:10,740 --> 00:34:15,440 +اصلا and I just give you the tax exempted و بعطيك + +457 +00:34:15,440 --> 00:34:19,640 +الدريبة and I'm asking you what is the equivalent + +458 +00:34:19,640 --> 00:34:24,280 +rate of return if you know this بال equivalent + +459 +00:34:24,280 --> 00:34:30,260 +rate of return يعني متى ال R هتساوي ال RM you + +460 +00:34:30,260 --> 00:34:35,540 +understand؟ بس ال RM هي النمر اللي بيبقى بالعالم + +461 +00:34:44,700 --> 00:34:50,480 +خلّينا .. خلّينا ال investors تبقوا علينا ال + +462 +00:34:50,480 --> 00:34:56,300 +investors بالاخير معنيين في العائد عندهم انت عندك + +463 +00:34:56,300 --> 00:35:01,670 +سندين سند عليه دريبة و سند ماعليهش دريبةمش دايما + +464 +00:35:01,670 --> 00:35:04,850 +السند اللي ماعنوش ضريبة is preferable مش .. مش + +465 +00:35:04,850 --> 00:35:08,610 +دايما بنات مش دايما السند اللي عليه اللي معاه فيه + +466 +00:35:08,610 --> 00:35:12,290 +مرة ضريبة هو كويس فال investors أول ما بيطلع لازم + +467 +00:35:12,290 --> 00:35:16,370 +يحسب ال return من هاد و ال return من هاد و بيعمل + +468 +00:35:16,370 --> 00:35:19,790 +comparison between them إذا كان ال return من ال + +469 +00:35:19,790 --> 00:35:23,150 +taxable أفضل فأنا بروح على ال taxable if the + +470 +00:35:23,150 --> 00:35:27,010 +return of the exempted so I prefer the exempted + +471 +00:35:27,010 --> 00:35:30,680 +لأن ال .. the ..we assume that the investors are + +472 +00:35:30,680 --> 00:35:34,820 +rational يعني بالعربي يا بنات لو أنتوا روحتوا على + +473 +00:35:34,820 --> 00:35:40,620 +البلد بدكم تشتريوا a t-shirt ف how much this one + +474 +00:35:40,620 --> 00:35:43,740 +this is twenty شاكل and another one say this is + +475 +00:35:43,740 --> 00:35:47,600 +twenty five شاكل so which you prefer يعني الأول + +476 +00:35:47,600 --> 00:35:49,760 +حكواكوا عشرين شاكل و التاني حكواكوا خمسة و عشرين + +477 +00:35:49,760 --> 00:35:54,640 +شاكل عاملين بتروحوالأ أبو العشرين طيب if you have + +478 +00:35:54,640 --> 00:35:58,900 +two projects لو كان عندي مشروعين مشروع بيعطيني 10% + +479 +00:35:58,900 --> 00:36:04,520 +ومشروع بيعطيني 12% اي مشروع أروح؟ أبو 12% and this + +480 +00:36:04,520 --> 00:36:08,840 +is the same لو كان عندي سندين واحد بيعطيني اتناشر + +481 +00:36:08,840 --> 00:36:10,660 +في المية وواحد عشر في المية بروح أبو اتناشر في + +482 +00:36:10,660 --> 00:36:14,180 +المية but the problem is we have taxable and we + +483 +00:36:14,180 --> 00:36:18,940 +have non-taxable so we justdo the taxable one + +484 +00:36:18,940 --> 00:36:21,760 +calculate the taxation then what is the equivalent + +485 +00:36:21,760 --> 00:36:27,220 +rate of return just to conclude احنا حكينا على ال + +486 +00:36:27,220 --> 00:36:30,220 +bond market و حكينا على ال governments ال + +487 +00:36:30,220 --> 00:36:32,860 +municipal bonds و حكينا على ال treasury notes و + +488 +00:36:32,860 --> 00:36:37,580 +treasury bills and that's it in the in the next in + +489 +00:36:37,580 --> 00:36:39,460 +the next meeting I will focus on the corporate + +490 +00:36:39,460 --> 00:36:40,900 +bonds and stocks + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_postprocess.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..f4e3600d528df1d7fb3438d910fcd3e7172e8730 --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_postprocess.srt @@ -0,0 +1,2288 @@ +1 +00:00:21,330 --> 00:00:25,510 +طيب احنا نرجع من جديد و نحكي عن ال .. المرة اللي + +2 +00:00:25,510 --> 00:00:31,150 +فاتت كنا حكينا عن ال markets and competitives and + +3 +00:00:31,150 --> 00:00:34,510 +we talked about risk and return trade-off العلاقة + +4 +00:00:34,510 --> 00:00:38,130 +بين العقد و المخاطر و حكينا there is no free lunch + +5 +00:00:38,130 --> 00:00:45,010 +مافيش اشي ببلاش okay و بعدين حكينا عن ال .. ال + +6 +00:00:45,010 --> 00:00:47,950 +efficient market و حكينا انه في عند نوعين من ال + +7 +00:00:47,950 --> 00:00:51,670 +investorsفي عندنا active وفي عندنا passive + +8 +00:00:51,670 --> 00:00:55,210 +managers هلأ بنحكي عن ال players in the financial + +9 +00:00:55,210 --> 00:00:59,030 +markets مين هم اللي بيحركوا السوق السوق المالي + +10 +00:00:59,030 --> 00:01:04,430 +عادة في عندنا اللي هم ال business firms, net + +11 +00:01:04,430 --> 00:01:06,370 +borrowers و ال household, net savers و ال + +12 +00:01:06,370 --> 00:01:08,690 +government طبعا هذا الحاجة ناقه برضه المرة الفاترة + +13 +00:01:08,690 --> 00:01:12,030 +هلأ ندخل في in details ندخل في التفاصيل + +14 +00:01:14,840 --> 00:01:18,080 +ال financial intermediaries ايش .. what it means + +15 +00:01:18,080 --> 00:01:22,220 +financial intermediaries احنا + +16 +00:01:22,220 --> 00:01:26,500 +المرة الفاتة حكينا انه ال .. عندي انا هان ال + +17 +00:01:26,500 --> 00:01:30,480 +savers وعندي + +18 +00:01:30,480 --> 00:01:36,760 +.. او عندي ال borrowers اه + +19 +00:01:36,760 --> 00:01:40,500 +المقترضينهلأ مافيشش .. there is no direct relation + +20 +00:01:40,500 --> 00:01:43,380 +between the savers and borrowers مافيش علاقة + +21 +00:01:43,380 --> 00:01:47,760 +مباشرة بين ال savers و ال borrowers يعني مثلا لو + +22 +00:01:47,760 --> 00:01:52,200 +هدول معاهم 100 دولار يعني واحد معاه 100 دولار + +23 +00:01:52,200 --> 00:01:58,250 +ازيادة عن حاجته ايش ممكن يسوي؟المفروض لو فيش + +24 +00:01:58,250 --> 00:02:01,590 +financial intermediaries لو فيش وسطاء ماليين بتروح + +25 +00:02:01,590 --> 00:02:04,230 +يدور على واحد بحاجة لل 100 دولار عشان يعمل + +26 +00:02:04,230 --> 00:02:08,650 +investment طب شوفوا how .. how much time it takes + +27 +00:02:08,650 --> 00:02:12,630 +to look for a one needs of money يعني جداش هو + +28 +00:02:12,630 --> 00:02:19,090 +هيدور على واحد بيحتاج الفلوس هذا واحد اتنين how he + +29 +00:02:19,090 --> 00:02:24,150 +or she wants to secure that his money will back و + +30 +00:02:24,150 --> 00:02:28,810 +كيف هو بيتأكد ان فلوسه هترجعلهكمان شغلة تانية اذا + +31 +00:02:28,810 --> 00:02:33,890 +ال investors or savers face challenges to locate + +32 +00:02:33,890 --> 00:02:38,170 +the borrowers يعني بيواجهوا صعوبات حتى يفتشوا على + +33 +00:02:38,170 --> 00:02:42,090 +ال borrowers so the financial intermediaries + +34 +00:02:42,090 --> 00:02:47,010 +facilitate the relationship between savers and + +35 +00:02:47,010 --> 00:02:52,710 +borrowers فهم موجودين بالمنطقة هذه ال financial + +36 +00:02:52,710 --> 00:02:59,770 +intermediariesFinancial intermediaries، FI، الهدف + +37 +00:02:59,770 --> 00:03:01,910 +الرئيسي للهدف الانتقال الانتقال الانتقال الانتقال + +38 +00:03:01,910 --> 00:03:03,170 +الانتقال الانتقال الانتقال الانتقال الانتقال + +39 +00:03:03,170 --> 00:03:04,030 +الانتقال الانتقال الانتقال الانتقال الانتقال + +40 +00:03:04,030 --> 00:03:06,130 +الانتقال الانتقال الانتقال الانتقال الانتقال + +41 +00:03:06,130 --> 00:03:06,510 +الانتقال الانتقال الانتقال الانتقال الانتقال + +42 +00:03:06,510 --> 00:03:10,770 +الانتقل الانتقل الانتقل الانتقل الانتقل الانتقل + +43 +00:03:10,770 --> 00:03:15,830 +الانتقل الانتقل + +44 +00:03:15,830 --> 00:03:20,900 +الانتقل الانتقل الانتو بالعكس مثلا احنا هلا دفعنا + +45 +00:03:20,900 --> 00:03:24,020 +المية دولار دفعناهم لل borowers and the borowers + +46 +00:03:24,020 --> 00:03:27,740 +they invest the one hundred dollar and later on + +47 +00:03:27,740 --> 00:03:30,160 +they have to pay back the one hundred dollar to + +48 +00:03:30,160 --> 00:03:36,040 +the savers so this is why take the savers pay to + +49 +00:03:36,040 --> 00:03:40,760 +the borowers and borowers pay for the savers take + +50 +00:03:40,760 --> 00:03:47,020 +like this chartSo this is the flow of .. of funds + +51 +00:03:47,020 --> 00:03:55,080 +from the savers to the borrowers okay ال savers + +52 +00:03:55,080 --> 00:04:02,300 +اللي معاهمه فلوس ال borrowers + +53 +00:04:02,300 --> 00:04:06,620 +اللي هو أحمد مانفلنبان صح احنا مافي نشوف ال savers + +54 +00:04:06,620 --> 00:04:11,890 +مافي نشوف اللي هو الإبانيزرyes يعني هال ال + +55 +00:04:11,890 --> 00:04:17,170 +intermediaries الشركات الوساطة الوساطاء الماليين + +56 +00:04:17,170 --> 00:04:20,650 +هم بيعملوا facilitate لل relationship between the + +57 +00:04:20,650 --> 00:04:24,110 +servers and borrowers يعني ممكن تمثلوا الكلام هذا + +58 +00:04:24,110 --> 00:04:27,830 +يعني يكون في ناس معهم فلوس موجودين على الجانب + +59 +00:04:27,830 --> 00:04:30,410 +اليمين و ناس اللي معهم مش فلوس موجودين على الجانب + +60 +00:04:30,410 --> 00:04:34,540 +اليسار هدول لإنهم بيعرفوش بعضbecause they don't + +61 +00:04:34,540 --> 00:04:37,920 +know each other so the .. the financial + +62 +00:04:37,920 --> 00:04:42,800 +intermediaries facilitate the relationship between + +63 +00:04:42,800 --> 00:04:46,860 +the savers and the borrowers طب مين هم ال + +64 +00:04:46,860 --> 00:04:50,320 +financial intermediaries؟ this is the question مين + +65 +00:04:50,320 --> 00:04:53,380 +هم ال financial intermediaries؟ ال financial + +66 +00:04:53,380 --> 00:04:59,310 +intermediariesOkay banks خلّيني أشوف هم مين يعني + +67 +00:04:59,310 --> 00:05:04,790 +هم بتحكي ال banks okay banks okay مين كمان البنوك + +68 +00:05:04,790 --> 00:05:08,890 +investment companies investment companies + +69 +00:05:08,890 --> 00:05:12,230 +companies + +70 +00:05:12,230 --> 00:05:16,450 +credit unions إيش يعني credit unions + +71 +00:05:19,330 --> 00:05:24,570 +اه اتحادات الاعتمان او الشركات الاعتمانية الشركات + +72 +00:05:24,570 --> 00:05:29,630 +اللي بتقدم الاعتمان بيسموها credit union بتقدر + +73 +00:05:29,630 --> 00:05:34,630 +تعطوني مثال عليهم دول credit unions لأ تأمين هذي + +74 +00:05:34,630 --> 00:05:40,910 +الشركة تأمينممكن اه ممكن أصالة فاتن save children + +75 +00:05:40,910 --> 00:05:47,050 +okay مين كمان انيرة مثلا US aid ال honor one كمان + +76 +00:05:47,050 --> 00:05:54,130 +ممكن تقدم ال unicef شوفتوا هدول ممكن trade .. ممكن + +77 +00:05:54,130 --> 00:05:57,170 +إغاثة كاتوليكية كمان تشتغل الشغل هاد فهدول بيسموهم + +78 +00:05:57,170 --> 00:06:03,070 +trade unions مؤسسات بتقدم اقتراض او بتقدم اقتمال + +79 +00:06:03,070 --> 00:06:09,570 +لل .. لل .. لل porvosال insurance companies؟ + +80 +00:06:09,570 --> 00:06:14,630 +الشركات التأمين؟ اه مين بيعرف كيف شركات التأمين + +81 +00:06:14,630 --> 00:06:20,790 +بتشتغل؟ يالا كيف شركات التأمين بتعمل .. بتاخد من + +82 +00:06:20,790 --> 00:06:23,870 +ال savers و بتعطي ل ال borrowers؟ عن طريق السلحات + +83 +00:06:23,870 --> 00:06:26,670 +التأمين اللي بيبقى ياخد الاصابيين .. بالظبط .. + +84 +00:06:26,670 --> 00:06:31,770 +الشركة فإن ما يحصل إنه حادث .. هتقوم معاهم إيش؟ + +85 +00:06:32,380 --> 00:06:35,960 +يعني انت .. انت مثلا you are saving كل شهر تدفع + +86 +00:06:35,960 --> 00:06:41,400 +فلوس كأقصاد تأمين لشركة و later on in the future + +87 +00:06:41,400 --> 00:06:45,920 +في المستقبل لما الواحد يتقاعد بياخد الفلوس هذه في + +88 +00:06:45,920 --> 00:06:46,400 +المستقبل + +89 +00:06:49,270 --> 00:06:51,730 +يعني اللي بيروح عليك تقنية و اللي بيروح أكثر تقنية + +90 +00:06:51,730 --> 00:06:56,210 +بيروح عليك يدهد .. يدهد الأمار يعطيها لأشخاص تانية + +91 +00:06:56,210 --> 00:07:00,070 +يستفيدوا منها يستفيدوا منها okay صحيح اذا زي ما + +92 +00:07:00,070 --> 00:07:04,370 +تشايفين investment companies شركات الاستثمار شركات + +93 +00:07:04,370 --> 00:07:09,070 +الاستثمار هاي بت .. مهمتها انه تكوين شغل اسمها ال + +94 +00:07:09,070 --> 00:07:11,250 +martial funds martial + +95 +00:07:13,010 --> 00:07:17,750 +funds نحكي عن marital funds كمان مهمتهم managing + +96 +00:07:17,750 --> 00:07:18,630 +the portfolios + +97 +00:07:21,770 --> 00:07:24,330 +إدارة المحافظة الاستثمارية يعني mutual funds + +98 +00:07:24,330 --> 00:07:27,730 +صناديق الاستثمار ال portfolios اللي هو محافظ + +99 +00:07:27,730 --> 00:07:31,670 +الاستثمار ايش يعني ال mutual funds الصناديق + +100 +00:07:31,670 --> 00:07:35,370 +الاستثمار هي صناديق ضخمة جدا يعني ممكن يكون يصل + +101 +00:07:35,370 --> 00:07:40,070 +لعشرين لمية مليون دولار جاي هذا الصناديق من + +102 +00:07:40,070 --> 00:07:44,450 +استثمارات الناس الناس العاديين يعني مثلا لو شخص + +103 +00:07:44,450 --> 00:07:48,250 +معاه مية دولار هذا الشخص اللي معاه مية دولار بده + +104 +00:07:48,250 --> 00:07:49,630 +يدخل في الصناديق الاستثمار + +105 +00:07:52,840 --> 00:07:56,320 +بروح بتصل في ال investment companies اللي هو شركات + +106 +00:07:56,320 --> 00:07:59,920 +الاستثمار شركات الاستثمار هذه عاملة صناديق هذه + +107 +00:07:59,920 --> 00:08:02,740 +الصناديق هتم الاستثمار فيها مثلا في أوروبا في + +108 +00:08:02,740 --> 00:08:06,920 +أفريقيا في دول معينة فبحطول ال 100 دولار في هذا + +109 +00:08:06,920 --> 00:08:12,740 +الصندوق يعني كأنه فيها صندوق okay و بتيجي بحطوا ال + +110 +00:08:12,740 --> 00:08:16,560 +100 دولار في هذا الصندوق طبعا millions of people + +111 +00:08:16,560 --> 00:08:21,430 +ملايين الناس هيحطوا في هذا الصندوقOkay يعني هتيجي + +112 +00:08:21,430 --> 00:08:29,150 +لناس كتير يساهموا في هذا الصندوق لنفترض انه صار + +113 +00:08:29,150 --> 00:08:34,430 +قيمة الصندوق five million يتم + +114 +00:08:34,430 --> 00:08:40,090 +تحويل الوحدات بالدولار إلى أسهم في الصندوق هو بتاع + +115 +00:08:40,090 --> 00:08:43,870 +اللي بيحكوا كل مية دولار بتساوي سهم واحد أو وحدة + +116 +00:08:43,870 --> 00:08:46,830 +واحدة بلاش نحكي أسهم بلاش نخربط مع الأسهم وحدة + +117 +00:08:46,830 --> 00:08:51,260 +واحدة لو عندي خمسة مليون دولارخمسة مليون دولار + +118 +00:08:51,260 --> 00:08:57,440 +أكمل وحدة بيصيروا نحكي خمسة مليون تقسيم مية دولار + +119 +00:08:57,440 --> 00:09:01,760 +الوحدة الواحدة تساوي مية دولار فبطلع قيمة الوحدات + +120 +00:09:01,760 --> 00:09:05,540 +اللي في الصندوق هلأ كيف بيحسبوا الربح و الخسارة؟ + +121 +00:09:06,510 --> 00:09:11,090 +الوحدات هذه لها سعر وليكن نبدأ في bar value 100$ + +122 +00:09:11,090 --> 00:09:16,170 +الbar value يعني قيمة الإسمية 100$ بتبدأ أسعار + +123 +00:09:16,170 --> 00:09:20,570 +الوحدة ترتفع و تنخفض في السوق المالي وبناء عليه هي + +124 +00:09:20,570 --> 00:09:25,880 +تم حساب الربح والخسارةهذه الصناديق مغلقة قد تكون + +125 +00:09:25,880 --> 00:09:30,440 +صناديق سنوية يعني يتم فتح الصندوق او انهاء الصندوق + +126 +00:09:30,440 --> 00:09:34,000 +مع نهاية السنة و بيشوفوا كام ربح الصندوق عادة هذه + +127 +00:09:34,000 --> 00:09:38,480 +الصناديق بتعمل long term investments استثمارات + +128 +00:09:38,480 --> 00:09:41,280 +طويلة أجل عادة بيروحوا مثلا بيستثمروا في أفريقيا + +129 +00:09:41,280 --> 00:09:43,760 +بيفتحوا شركات مثلا في أفريقيا بيروحوا مثلا + +130 +00:09:43,760 --> 00:09:47,400 +بالمكسيك بيروحوا بيعملوا شغل بالمكسيك و هاي يعني + +131 +00:09:47,400 --> 00:09:49,200 +بتكون long term investment شوفوا ال 100 دولار + +132 +00:09:49,200 --> 00:09:53,590 +تبعتكماللي انتوا دفعتوها اشي بسيط لكن هذه ال 100 + +133 +00:09:53,590 --> 00:09:57,350 +دولار حطت فى صندوق استثمار وراحت فتحت شركات ضخمة + +134 +00:09:57,350 --> 00:10:01,250 +فى العالم فيعني don't underestimate the importance + +135 +00:10:01,250 --> 00:10:05,310 +of your 100 دولار يعني ما .. ما تستهنوش فى ال 100 + +136 +00:10:05,310 --> 00:10:07,650 +دولار اللي انتوا بتدفعوها دول because they do big + +137 +00:10:07,650 --> 00:10:12,450 +investments using the .. the mutual funds ال + +138 +00:10:12,450 --> 00:10:21,590 +portfolios المحافظة الاستثمارية هي عبارة عناستثمار + +139 +00:10:21,590 --> 00:10:27,650 +متنوع في عدة مجالات okay يعني احنا عندنا هان + +140 +00:10:27,650 --> 00:10:31,890 +خلّيني نرجع لفكرة ال mutual funds ال mutual funds + +141 +00:10:31,890 --> 00:10:39,370 +بشمل عدة محافظ استثمارية حطينا ال 100 دولار في هاي + +142 +00:10:39,370 --> 00:10:43,230 +ال mutual funds ال mutual funds حكينا بشمل على 5 + +143 +00:10:43,230 --> 00:10:49,950 +مليون دولار في استثمارات في أفريقيا مثلافي + +144 +00:10:49,950 --> 00:10:53,790 +استثمارات مثلا في الماكسيك ففي أفريقيا بنروح + +145 +00:10:53,790 --> 00:10:56,610 +بنستثمر في محفظة استثمارية في أفريقيا محفظة + +146 +00:10:56,610 --> 00:10:59,810 +استثمارية يعني portfolios إذا المواتشال funds + +147 +00:10:59,810 --> 00:11:04,270 +includes many or different portfolios مجموعة من + +148 +00:11:04,270 --> 00:11:07,710 +محافظات استثمارية والمحفظة الاستثمارية الواحدة + +149 +00:11:07,710 --> 00:11:13,050 +بتشمل كمان بتشمل عدة استثمارات يعني مثلا in Africa + +150 +00:11:13,050 --> 00:11:15,830 +ممكن احنا نعمل investment في ال communication + +151 +00:11:18,440 --> 00:11:22,300 +Okay ممكن نعمل investment في ال .. في ال + +152 +00:11:22,300 --> 00:11:27,600 +infrastructure في ال .. يعني في ال .. في البنية + +153 +00:11:27,600 --> 00:11:30,340 +التحتية و ممكن نعمل investment مثلا في ال + +154 +00:11:30,340 --> 00:11:36,940 +nutrition في التخزين يعني مثلا بتعرفوا مثلا في + +155 +00:11:36,940 --> 00:11:43,040 +الصومال فيه بتواجههم مشكلة الصومال إيش أهم إنتاج + +156 +00:11:43,040 --> 00:11:48,180 +في الصومال عندهم؟لأ أهم إنتاج منتج استراتيجي عندهم + +157 +00:11:48,180 --> 00:11:51,940 +قالتنا الموز الموز اه + +158 +00:11:55,410 --> 00:11:59,110 +اه فبيحتاج .. فمن أكبر المنتجين للموز في العالم هم + +159 +00:11:59,110 --> 00:12:04,630 +الصومال فهدول لإنهم ما عندهمش إمكانيات ي .. يروحوا + +160 +00:12:04,630 --> 00:12:08,230 +يخطفوا الموز و يحطوه في حويات و الحويات تنقلهم + +161 +00:12:08,230 --> 00:12:11,390 +لأنحاء العالم بدون .. تحتاج طائرات و بتحتاج + +162 +00:12:11,390 --> 00:12:15,990 +لإمكانيات ضخمة للاستثمار فبصير تم تشكيل محافظة + +163 +00:12:15,990 --> 00:12:22,840 +استثمارية تعمل استثمارات بنقل ال .. المحصوليعني + +164 +00:12:22,840 --> 00:12:28,260 +بيكون عبارة .. okay بيكون عبارة عن عمليات النقل + +165 +00:12:28,260 --> 00:12:35,220 +بحتاجه لوسائل نقل متقدمة بحيث تحافظ على ال .. نضج + +166 +00:12:35,220 --> 00:12:39,060 +الموز نفسه، عدم التلف للموز، بيحتاج إلى ثلاجات + +167 +00:12:39,060 --> 00:12:42,900 +معينة بخصائص معينة حتى لما ينقل بالطائرات يكون له + +168 +00:12:42,900 --> 00:12:47,750 +خصائص معينة وبالتاليلأنه في .. في مناطق الفقر هذه + +169 +00:12:47,750 --> 00:12:51,170 +مابحتاجوا .. مابقدروش يغطوا هذه المجالات ففي + +170 +00:12:51,170 --> 00:12:54,210 +صناديق استثمار بتروح تعمل استثمارات في أفريقيا و + +171 +00:12:54,210 --> 00:12:59,210 +في المكسيك و في بعض الدول في آسيا حتى يروحوا ي .. + +172 +00:12:59,210 --> 00:13:05,250 +طبعا استفادتهم انه استفادة ..ليست بسيطة طبعا هم + +173 +00:13:05,250 --> 00:13:08,910 +بيشتريوا الموز بأسعار معينة و بيبيعوا الموز بأسعار + +174 +00:13:08,910 --> 00:13:12,490 +أعلى وهذا بيعطيهم فرص استثمارية عالية جدا okay هاي + +175 +00:13:12,490 --> 00:13:17,210 +أمثلة عن كيف ان هم ممكن هم they invest في ال .. في + +176 +00:13:17,210 --> 00:13:19,770 +ال mutual funds and invest in the portfolios في + +177 +00:13:19,770 --> 00:13:24,050 +المحافظة الاستثمارية اذا الصندوق الاستثمار ال + +178 +00:13:24,050 --> 00:13:27,750 +mutual funds بيشمل عدة محافظة استثمارية ممكن + +179 +00:13:27,750 --> 00:13:31,110 +هيحكينا Africa ممكن هم يستهمروا مثلا بال .. بال + +180 +00:13:31,110 --> 00:13:37,210 +energyفي ال middle east في الشرق الأوسط بيستثمروا + +181 +00:13:37,210 --> 00:13:39,610 +في ال energy في ال middle east لو احنا جينا و جينا + +182 +00:13:39,610 --> 00:13:42,070 +على شاط بحر غزا هن .. هنشوف اللي هو ال British + +183 +00:13:42,070 --> 00:13:45,230 +petroleum اللي هو شركة .. شركة البريطانية هذه ال + +184 +00:13:45,230 --> 00:13:50,530 +.. okay اللي هو استخراج الغاز فهذا بيكون عبارة عن + +185 +00:13:50,530 --> 00:13:55,130 +شركات استثمار عملت investment فتحت محفظ استثمارية + +186 +00:13:55,130 --> 00:13:57,630 +أو صندوق استثمار و عملت investment في .. في هذا + +187 +00:13:57,630 --> 00:14:03,540 +المجالOkay فيعني هذا دور المحافظة الاستثمارية + +188 +00:14:03,540 --> 00:14:09,380 +صناديخ الاستثمار بتوفر كتير فلوس لل investors او + +189 +00:14:09,380 --> 00:14:12,340 +لل bourgeois يعني زي ما حكينا ال one hundred + +190 +00:14:12,340 --> 00:14:16,020 +dollar هادي لما تكون من مليون واحد فتصوروا ميت + +191 +00:14:16,020 --> 00:14:20,160 +مليون بيصير لو كل واحد شهريا دفع just one hundred + +192 +00:14:20,160 --> 00:14:24,550 +dollarو and invest in these mutual funds so it + +193 +00:14:24,550 --> 00:14:28,470 +means the business will grow up هي .. هي ال + +194 +00:14:28,470 --> 00:14:31,870 +business يزيد و يصير توسع و يصير نمو لكن لو أجينا + +195 +00:14:31,870 --> 00:14:34,210 +احنا ال 100 hundred دولار تبعتنا شوفوا الفرق بين + +196 +00:14:34,210 --> 00:14:38,550 +the rule of financial intermediaries and if there + +197 +00:14:38,550 --> 00:14:41,170 +is no financial intermediaries اذا كان عندي + +198 +00:14:41,170 --> 00:14:44,250 +financial intermediaries و لو ماكنش ال 100 .. ال + +199 +00:14:44,250 --> 00:14:46,870 +100 دولار هذي اللي معايا بقدر أنه أروح فيها على + +200 +00:14:46,870 --> 00:14:49,950 +أفريقيا أعمل investments طب بقدر أعمل secret + +201 +00:14:49,950 --> 00:14:55,390 +hadithبقدر أعمل مثلا أنجل الموز من الصومال لانحاء + +202 +00:14:55,390 --> 00:14:59,210 +العالم بقدر مثلا أعمل investment في ال energy مثلا + +203 +00:14:59,210 --> 00:15:03,230 +بالعالم it's impossible so the one hundred dollar + +204 +00:15:03,230 --> 00:15:06,830 +this one hundred dollar make the mutual funds and + +205 +00:15:06,830 --> 00:15:11,460 +mutual funds invest over all the worldهذا ال .. + +206 +00:15:11,460 --> 00:15:13,820 +فعشان هي واحد بتسأل من وين المصاري millions of + +207 +00:15:13,820 --> 00:15:16,020 +dollars من وين جاي هالواحد بيمتلكهم؟ لأ because + +208 +00:15:16,020 --> 00:15:19,700 +mutual funds is considered as a units وحدات زي ما + +209 +00:15:19,700 --> 00:15:24,640 +حكينا وحدة من الدولار and it's collected from the + +210 +00:15:24,640 --> 00:15:26,800 +servers هدول ال servers اللي معاهم اللي ميتهندروا + +211 +00:15:26,800 --> 00:15:31,600 +الدولار حطوها ب .. معال .. مع ال investment + +212 +00:15:31,600 --> 00:15:34,300 +companies و ال investment .. investment companies + +213 +00:15:34,300 --> 00:15:36,780 +they channel it to the borrowers و ال borrowers + +214 +00:15:36,780 --> 00:15:40,040 +راحوا يعملوا investment big .. big investment في + +215 +00:15:40,040 --> 00:15:43,900 +around the world okay فتتفاجأوش لما تكون الشركة + +216 +00:15:43,900 --> 00:15:48,020 +مثلا عندها trillion of dollar هذي trillion of + +217 +00:15:48,020 --> 00:15:51,060 +dollar is coming from the small investors جاي من + +218 +00:15:51,060 --> 00:15:57,180 +ال small investors لزهار استثماراتيعني مثلا لو + +219 +00:15:57,180 --> 00:16:02,140 +احنا فكرنا مثلا نشتغل مثلا شركة، نعمل شركة + +220 +00:16:02,140 --> 00:16:06,500 +استثمارات في خطاعة غزة و .. و هذه رقم اسمها thirty + +221 +00:16:06,500 --> 00:16:10,240 +million، تلاتين مليون دولار و الناس بيقول oh wow + +222 +00:16:10,240 --> 00:16:15,140 +thirty millions how we can get this numberممكن + +223 +00:16:15,140 --> 00:16:18,480 +نجيب الرقم هذا بسهولة تلاتين مليون ممكن نجابه + +224 +00:16:18,480 --> 00:16:21,760 +بسهولة من خلال ال .. ال .. ال investors ال savers + +225 +00:16:21,760 --> 00:16:26,580 +ال savers مش شرط one saver have thirty million مش + +226 +00:16:26,580 --> 00:16:30,060 +شرط ال .. ال .. المستثمر الواحد او المدخل الواحد + +227 +00:16:30,060 --> 00:16:33,900 +يكون عنده تلاتين مليون ممكن هذا يكون مية دولار هذا + +228 +00:16:33,900 --> 00:16:37,000 +متين دولار هذا الف دولار at the end of the day we + +229 +00:16:37,000 --> 00:16:42,550 +will have the three hundred دولارمثلا في عندنا + +230 +00:16:42,550 --> 00:16:45,790 +مثلا بدون ذكر أسماء البنوك يعني في عندنا بنك من + +231 +00:16:45,790 --> 00:16:50,870 +البنوك بيعمل في غزة الودائع المقيمين في قطاع غزة + +232 +00:16:50,870 --> 00:16:54,750 +four billion مش four million four billion يعني + +233 +00:16:54,750 --> 00:16:58,110 +أربع مليارات دولارات دولار الضفة الغربي وقطع غزة + +234 +00:16:58,110 --> 00:17:03,510 +بس في بنك واحد عندهم أربع مليار دولارات ودائع فلو + +235 +00:17:03,510 --> 00:17:05,810 +احنا بدنا نفكر نفتح شركة just for thirty million + +236 +00:17:05,810 --> 00:17:10,580 +يعني نقدر احنا نفتح عشر شركاتأو نفتحنا 15 شركة من + +237 +00:17:10,580 --> 00:17:13,880 +ال big companies على مستوى الدفع الغربي و الخدعازة + +238 +00:17:13,880 --> 00:17:17,400 +شوفوا كيف ممكن احنا نعمل to change our investments + +239 +00:17:17,400 --> 00:17:21,280 +from the just depositing the bank into + +240 +00:17:21,280 --> 00:17:25,880 +industrialized investments لإن استثمارات صناعية و + +241 +00:17:25,880 --> 00:17:30,300 +استثمارات خدماتية okay هذا ال investment companies + +242 +00:17:30,300 --> 00:17:34,280 +لو حكينا على ال banks على البنوك we have different + +243 +00:17:34,280 --> 00:17:38,830 +banksفي عندنا بنوك مختلفة ممكن تعطونا إيش أسماء .. + +244 +00:17:38,830 --> 00:17:42,250 +إيش البنوك ال .. لأ بديش أسماء بنوك بدي أنواع + +245 +00:17:42,250 --> 00:17:49,950 +البنوك فضل بنك المركزي the central bank إيش ال + +246 +00:17:49,950 --> 00:17:57,050 +central bank هذا شغلته هو is بتعرفي .. بتعرفي أب + +247 +00:17:57,050 --> 00:18:02,130 +البنوك he is the bank of banks أو or the father of + +248 +00:18:02,130 --> 00:18:07,600 +banks هو أب البنوكis .. is organizing and + +249 +00:18:07,600 --> 00:18:11,840 +observing okay and managing the other banks or the + +250 +00:18:11,840 --> 00:18:15,120 +commercial and other banks يعني هو بدير .. اه عفوا + +251 +00:18:15,120 --> 00:18:19,860 +هو بي .. بيراقب و بتابع و بنظم عمليات البنوك نفسها + +252 +00:18:19,860 --> 00:18:23,640 +controlling them طب هذا ال central bank غير ال + +253 +00:18:23,640 --> 00:18:29,070 +central bank مين؟ البناية الوراأه غير ال central + +254 +00:18:29,070 --> 00:18:31,370 +bank اتفضلى .. commercial bank .. commercial bank + +255 +00:18:31,370 --> 00:18:32,270 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +256 +00:18:32,270 --> 00:18:32,450 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +257 +00:18:32,450 --> 00:18:33,910 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +258 +00:18:33,910 --> 00:18:33,930 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +259 +00:18:33,930 --> 00:18:35,230 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +260 +00:18:35,230 --> 00:18:40,170 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +261 +00:18:40,170 --> 00:18:42,910 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +262 +00:18:42,910 --> 00:18:46,250 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +263 +00:18:46,250 --> 00:18:48,010 +ال .. ال .. ال + +264 +00:18:51,990 --> 00:18:55,450 +أيوة في .. في investment banks بس ال investment + +265 +00:18:55,450 --> 00:18:58,470 +banks خدوا بالكم مش هو ال investment banks اللي + +266 +00:18:58,470 --> 00:19:02,710 +احنا بنعرفه investment banks له شغل بختلف عن شغل + +267 +00:19:02,710 --> 00:19:07,990 +البنك التجاري البنك الاستثمار مهمته انه يشجع + +268 +00:19:07,990 --> 00:19:13,770 +الاستثمار okay يعني مثلا ي .. زي بنوك الصناعية + +269 +00:19:13,770 --> 00:19:20,060 +يروح مثلا يوجه الأموال تبعته نحو الصناعاتOkay يوجه + +270 +00:19:20,060 --> 00:19:24,260 +الأموال تبعته في تمويل الشركات و خاصة في شغل اسمها + +271 +00:19:24,260 --> 00:19:29,240 +primary .. primary markets + +272 +00:19:31,580 --> 00:19:34,560 +Okay primary market تذكروا هذا المصطلح primary + +273 +00:19:34,560 --> 00:19:40,260 +markets هو is in charge is in charge to do the + +274 +00:19:40,260 --> 00:19:43,760 +primary markets البنك الاستثمار هو المسئول عن + +275 +00:19:43,760 --> 00:19:47,260 +عملية ال primary market اللي هو سوق الأصدارات + +276 +00:19:47,260 --> 00:19:50,620 +الأولية يعني أيه سوق الأصدارات الأولية؟ لما الشركة + +277 +00:19:50,620 --> 00:19:54,760 +.. أول شركة ما تنتشق بتحتاج تترح أسهم وين بتترح + +278 +00:19:54,760 --> 00:19:58,040 +الأسهم هذه؟ لازم تترحها في بنك الاستثمار احنا في + +279 +00:19:58,040 --> 00:20:02,300 +القطاع الغزة أو في الضفة الغربي يعني هذا الدورلأنه + +280 +00:20:02,300 --> 00:20:06,120 +ماعناش professional investment banks ماعناش بنوك + +281 +00:20:06,120 --> 00:20:10,520 +استثمار استثمارات احترافية او متخصصة فبلجأوا + +282 +00:20:10,520 --> 00:20:14,540 +للبنوك التجارية حتى يقوموا بهذا الدور وهذا اشي غلط + +283 +00:20:14,540 --> 00:20:18,720 +يصير بال .. لأن دور البنك الاستثمار هو دور يختلف + +284 +00:20:18,720 --> 00:20:21,760 +عن دور البنوك التجارية so be careful in the role + +285 +00:20:21,760 --> 00:20:25,120 +of commercial banks and the role of investment + +286 +00:20:25,120 --> 00:20:27,620 +banks ايش كمان عن الألوان من البنوك؟ + +287 +00:20:30,560 --> 00:20:34,600 +البنوك المتخصصة specialized bank زي ايش مثلا + +288 +00:20:34,600 --> 00:20:39,420 +specialized bank الزراعي بالظبط زي مثلا لو روحنا + +289 +00:20:39,420 --> 00:20:43,580 +احنا على مصر specialized bank هنلاقي اللي هو ال + +290 +00:20:43,580 --> 00:20:47,520 +بنك الاقتمام الزراعي بنك الاقتمام الزراعي هو بنك + +291 +00:20:47,520 --> 00:20:51,300 +متخصص just to invest in the agriculture areas هو + +292 +00:20:51,300 --> 00:20:55,020 +بس متخصصين بال agriculture اللي هو في الزراعة okay + +293 +00:20:55,020 --> 00:21:01,020 +فهذا البنوك بتتخصص بهذا المجالفي مثلا ال housing + +294 +00:21:01,020 --> 00:21:06,260 +bank housing bank بنوك ال .. ال .. الاسكان و بنوك + +295 +00:21:06,260 --> 00:21:10,060 +ال real estate هذه مهمتها إيش؟ to .. to channel + +296 +00:21:10,060 --> 00:21:13,820 +the funds to the housing investments اللي هو بناء + +297 +00:21:13,820 --> 00:21:17,960 +البيوت و بناء المنازل و بناء الطرقات فهم بتخصصين + +298 +00:21:17,960 --> 00:21:23,420 +بهذا المجال okay إيش في عندك بنوك؟ Islamic bank + +299 +00:21:23,420 --> 00:21:25,100 +طبعا Islamic bank + +300 +00:21:29,190 --> 00:21:32,410 +لأ ما بتستخدم القلول ال Islamic part بيستخدموا + +301 +00:21:32,410 --> 00:21:36,910 +المرابحة و المضاربة و المشاركة okay فعندهم + +302 +00:21:36,910 --> 00:21:39,430 +المضاربة و المرابحة و المشاركة + +303 +00:21:42,060 --> 00:21:45,480 +لأ هم ما بيستخدموا القروض هم بيستخدموا يعني + +304 +00:21:45,480 --> 00:21:48,960 +بيستخدموا أدوات استثمارية بتختلف ممكن يكون .. ممكن + +305 +00:21:48,960 --> 00:21:53,420 +يكون ال investors من برا يشوف أنه مافيش اختلاف لكن + +306 +00:21:53,420 --> 00:21:56,760 +ال process فعلا هي في اختلاف لما بدك تاخد مرابحة + +307 +00:21:56,760 --> 00:22:01,900 +مثلا بتطلب أنه مايكونش .. يعني مايكونش ملكية الشئ + +308 +00:22:01,900 --> 00:22:07,120 +تكون للبنك فالبنك بيعمل عقد مع الشركة السيارات و + +309 +00:22:07,120 --> 00:22:10,860 +من ثم بيتم بيع السيارة من البنك ل .. ل هذا الشخص + +310 +00:22:11,620 --> 00:22:16,860 +Okay فهذا اختلف صحيح انه شكلا ممكن يكون متشابه لكن + +311 +00:22:16,860 --> 00:22:21,340 +مضمونا لأ فيه اختلاف وبتساهل احنا في ال .. و هيك + +312 +00:22:21,340 --> 00:22:25,000 +يعني الفرق بين .. بين ال .. بين اي شي حلال او اي + +313 +00:22:25,000 --> 00:22:28,660 +.. او اي شي محرم هو .. هو الشعر البسيط انه ال .. + +314 +00:22:28,660 --> 00:22:35,530 +ال .. اللي بتسير في المضمون تبعهالعملية نفسها ففي + +315 +00:22:35,530 --> 00:22:37,650 +عندنا البنوك الإسلامية البنوك الإسلامية لأ في + +316 +00:22:37,650 --> 00:22:40,350 +عندها المرابحة وفي عندنا المضاربة وفي عندنا + +317 +00:22:40,350 --> 00:22:42,730 +المشاركة وفي عندنا الاستثمار المتخصص وفي عندنا + +318 +00:22:42,730 --> 00:22:46,990 +الاستثمار اه كل هذا طبعا بتوفره البنوك الإسلامية + +319 +00:22:46,990 --> 00:22:50,690 +والبنوك الإسلامية اليوم كتير متطورة حتى يعني بنوك + +320 +00:22:50,690 --> 00:22:54,830 +أجنبية زي ال HSBC Bank HSBC Bank تاني أكبر بنك في + +321 +00:22:54,830 --> 00:23:01,380 +العالم بيقدم خدمات إسلامية بيسميها Amana Bankأمانة + +322 +00:23:01,380 --> 00:23:06,740 +بنك امانة بنك اللي هي خدمات استثمارية pure islamic + +323 +00:23:06,740 --> 00:23:10,440 +طبعا pure islamic يعني اسلامية مية في المية مافيش + +324 +00:23:10,440 --> 00:23:13,940 +فيها مشاكل بتاخد مرابحة بتاخد مضاربة بتاخد + +325 +00:23:13,940 --> 00:23:18,480 +استثمارات الوداق مافيش فيها عليها الفوائد اللي + +326 +00:23:18,480 --> 00:23:21,900 +الفوائد الربوية وبالتالي there is a spreading out + +327 +00:23:21,900 --> 00:23:26,920 +to the concept of islamic banking طبعا هذا بالنسبة + +328 +00:23:26,920 --> 00:23:32,950 +للبنوكبقى موجود .. هذا موجود في .. في لندن، في + +329 +00:23:32,950 --> 00:23:36,690 +بريطانيا و ال .. أصلا ال headquarter موجود في هونج + +330 +00:23:36,690 --> 00:23:42,050 +كونج لإن هو إجا بين اندماج لعدة .. لبن كين تمام؟ + +331 +00:23:42,050 --> 00:23:46,350 +اللي هو هونج كونج بانك فهذا ال .. البنك يعتبر تاني + +332 +00:23:46,350 --> 00:23:49,490 +أكبر بنك في العالم بعد دوتش بانكالدوتش بانك في + +333 +00:23:49,490 --> 00:23:53,670 +عنده 450 ألف .. دوتش بانك لأ .. دوتش بانك ألماني + +334 +00:23:53,670 --> 00:23:57,970 +.. بانك ألماني .. اه ف .. هذا ال بانك اللي هو دوتش + +335 +00:23:57,970 --> 00:24:03,850 +بانك عنده تقريبا ما يزيد عن 450 ألف موظفين موزعين + +336 +00:24:03,850 --> 00:24:08,610 +على أنحاء العالم وبالتالي يعني .. هذه البنوك + +337 +00:24:08,610 --> 00:24:13,520 +العالمية تقدم خدمات إسلاميةو اليوم في توجه كبير + +338 +00:24:13,520 --> 00:24:18,920 +لتقديم محافظ استثمارية إسلامية و قروض إستثمارية + +339 +00:24:18,920 --> 00:24:24,860 +إسلامية وهي ما يعني صارت توجه العالم بتقديم بعض + +340 +00:24:24,860 --> 00:24:30,800 +الخدمات الإسلامية okay ال insurance companies + +341 +00:24:30,800 --> 00:24:35,000 +حكينا فيهم بخدمة خدمات التأمينو هدول بيعتمدوا على + +342 +00:24:35,000 --> 00:24:38,300 +علم اسمه actuarials actuaries اللي هو علم + +343 +00:24:38,300 --> 00:24:42,260 +الاكتواريات علم الاكتواريات كتير بيستخدموا + +344 +00:24:42,260 --> 00:24:49,440 +الاحتمالات علم الاكتواريات actuarials اللي هو علم + +345 +00:24:49,440 --> 00:24:50,380 +الاكتواريات + +346 +00:25:01,110 --> 00:25:04,310 +Science هذا علم الاكتواريات بيستخدم كتير + +347 +00:25:04,310 --> 00:25:10,290 +الاحتمالات .. اه الاحتمالات و .. و نسبة ال .. نسبة + +348 +00:25:10,290 --> 00:25:14,710 +حدوث الحدث و نسبة الحوادث و كذا حتى يروح يحسب و + +349 +00:25:14,710 --> 00:25:19,690 +أخاط التأمين على ال investors تمام؟ + +350 +00:25:20,250 --> 00:25:23,090 +ال credit unions حكينا عندهم أمثلة كبيرة ل credit + +351 +00:25:23,090 --> 00:25:26,750 +unions اللي هو أن المؤسسات التأمين أو اتحادات + +352 +00:25:26,750 --> 00:25:30,350 +التأمين و البنات هتعطيطوني عدة أمثلة اعطوني مثلا + +353 +00:25:30,350 --> 00:25:38,080 +زي credit unions مثلا أصالع فاتن مين كمان أنااه + +354 +00:25:38,080 --> 00:25:43,260 +الإغاثة الإسلامية يعني يقدموا قروض ميسرة okay و + +355 +00:25:43,260 --> 00:25:48,180 +بيتم المستثمرين بي .. طب السؤال هدول مثلا زي أصالة + +356 +00:25:48,180 --> 00:25:51,540 +و فاتن و ال .. و أنيرة و save ال children و هذا من + +357 +00:25:51,540 --> 00:25:56,680 +وين بيجيبوا الأموال تبعتهم؟اه من .. من ال savers + +358 +00:25:56,680 --> 00:25:59,960 +.. من ال savers هدول international savers بروحوا ب + +359 +00:25:59,960 --> 00:26:05,280 +.. بستثمروا في هذه المؤسسات على أساس أنه ي .. يعني + +360 +00:26:05,280 --> 00:26:10,200 +يقوموا بعملية تنمية معينة في دول مثلا دول فقيرة + +361 +00:26:10,200 --> 00:26:16,480 +حتى يستطيعوا ينهضوا بال .. بالاقتصاد okay أي سؤال + +362 +00:26:16,480 --> 00:26:20,580 +على ال credit unions أو سؤال على ال financial + +363 +00:26:20,580 --> 00:26:21,580 +intermediaries + +364 +00:26:26,560 --> 00:26:31,260 +لأ ال insurance companies هم شركات تأمين يعني + +365 +00:26:31,260 --> 00:26:34,960 +مابعملوش ال insurance companies هدول بيقدموش + +366 +00:26:34,960 --> 00:26:40,320 +تسهيلات اقتمانية خد بالك ال competition هو يعني + +367 +00:26:40,320 --> 00:26:42,740 +كويس ان انت سألت السؤال هذا ان ال competition + +368 +00:26:42,740 --> 00:26:46,500 +بيكون بين ال insurance companies و ال investment + +369 +00:26:46,500 --> 00:26:52,350 +companies في نوع من منافسة بيناتهملما احنا نروح + +370 +00:26:52,350 --> 00:26:55,770 +ندفع أقصاد التأمين فبصير pool شوفوا انتوا من كلمة + +371 +00:26:55,770 --> 00:27:00,930 +pool pool and invest فشركات التأمين أكبر الشركات + +372 +00:27:00,930 --> 00:27:04,610 +اللي عندها saving لإنه كنا بندفع أقصاد تأمين + +373 +00:27:04,610 --> 00:27:09,170 +السيارة أقصاد تأمين المنازل أقصاد تأمين الحياة + +374 +00:27:09,170 --> 00:27:13,750 +تأمين العمال فبتدخل ايش؟ بتدخل هذه عبارة عن funds + +375 +00:27:13,750 --> 00:27:19,170 +هذه ال funds بحتاج لإيش؟ بحتاج ل channel ان احنا + +376 +00:27:19,170 --> 00:27:24,040 +نعمل investmentsفبدل ما يوجهوا هذا ال funds ل + +377 +00:27:24,040 --> 00:27:27,180 +investment companies by themselves invest this + +378 +00:27:27,180 --> 00:27:29,320 +money وعدم ان they play + +379 +00:27:32,600 --> 00:27:36,700 +a huge role in the capital markets يعني هذا + +380 +00:27:36,700 --> 00:27:40,860 +بيلعبوا دور كبير في النظام الرأسمالي هم بيأثروا ال + +381 +00:27:40,860 --> 00:27:43,740 +.. ال entrance companies هم the main players in + +382 +00:27:43,740 --> 00:27:46,060 +the .. in the financial markets هم اللي بيلعبوا + +383 +00:27:46,060 --> 00:27:48,940 +دور كبير في ال financial markets ف instead of + +384 +00:27:48,940 --> 00:27:52,510 +channel the money or the funds to theinvestment + +385 +00:27:52,510 --> 00:27:55,430 +companies they do it by themselves فممكن ما + +386 +00:27:55,430 --> 00:27:58,270 +تتفاجأوش ان ال insurance companies هم يروحوا + +387 +00:27:58,270 --> 00:28:00,430 +يعملوا investment في أفريقا و ممكن يعملوا + +388 +00:28:00,430 --> 00:28:02,590 +investment في ال .. في ال united states و في ال UK + +389 +00:28:02,590 --> 00:28:05,350 +في ال middle east بال .. بال .. بال European + +390 +00:28:05,350 --> 00:28:07,690 +countries so they don't have problems in investing + +391 +00:28:07,690 --> 00:28:11,130 +as long as they have the funds لأنهم عندهم الفلوس + +392 +00:28:11,130 --> 00:28:16,000 +و بالتالي they can do it by themselvesواضح الكلام + +393 +00:28:16,000 --> 00:28:19,260 +فال insurance companies مش بس هم they serving or + +394 +00:28:19,260 --> 00:28:23,800 +they provide insurance services but they provide + +395 +00:28:23,800 --> 00:28:27,020 +investment services فهم كمان بيروحوا بيعملوا + +396 +00:28:27,020 --> 00:28:32,120 +استثمارات هم اللي بياخدوا أقصاد التأمين من الناس + +397 +00:28:32,120 --> 00:28:37,100 +بيعملوا investment لهاي بيستثمروها في أماكن مختلفة + +398 +00:28:37,100 --> 00:28:42,630 +في العالمو هدول يعني هتلاق .. هتجدهم من مالكين + +399 +00:28:42,630 --> 00:28:45,590 +أكبر شركات في العالم هدول ال insurance companies + +400 +00:28:45,590 --> 00:28:49,610 +okay and they have a good experience in managing + +401 +00:28:49,610 --> 00:28:53,390 +other companies و عندهم خبرات كبيرة عالية جدا في + +402 +00:28:53,390 --> 00:29:00,830 +ان هم إدارة الشركات الغير تأمينية okay مكتوب كمان + +403 +00:29:00,830 --> 00:29:03,410 +بالكتاب المماشي البنك او ال .. + +404 +00:29:10,240 --> 00:29:18,580 +بس ال insurance + +405 +00:29:18,580 --> 00:29:22,840 +companies مابيعملوش الكلام هذا يعني مش شغلتهم انه + +406 +00:29:22,840 --> 00:29:26,520 +ياخدوا saving هم شغلتهم ايش؟ شغلتهم ياخدوا أقصاد + +407 +00:29:26,520 --> 00:29:31,060 +التأمين اللي هو بيسموها insurance installments + +408 +00:29:31,060 --> 00:29:34,520 +أقصاد التأمين اسمها insurance installments + +409 +00:29:42,520 --> 00:29:47,700 +فعشان هيك صحيح كلامك أنه مش هم أكبر ناس اللي + +410 +00:29:47,700 --> 00:29:50,860 +يعملوا intermediaries between the savers and + +411 +00:29:50,860 --> 00:29:54,240 +investors بط هم أكتر ناس اللي يعملوا investments + +412 +00:29:54,240 --> 00:29:57,820 +هم و مين؟ هم و ال investment companies هم و شركات + +413 +00:29:57,820 --> 00:30:04,290 +الاستثمارال .. ال .. ال .. ال .. ال .. ال .. ال .. + +414 +00:30:04,290 --> 00:30:04,530 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +415 +00:30:04,530 --> 00:30:04,690 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +416 +00:30:04,690 --> 00:30:05,470 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +417 +00:30:05,470 --> 00:30:06,290 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +418 +00:30:06,290 --> 00:30:10,130 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +419 +00:30:10,130 --> 00:30:12,670 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +420 +00:30:12,670 --> 00:30:13,050 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +421 +00:30:13,050 --> 00:30:13,310 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +422 +00:30:13,310 --> 00:30:21,890 +ال .. ال .. ال .. + +423 +00:30:31,700 --> 00:30:36,740 +Okay ال .. الناس اللي بيروحوا اللي هم ناس يعني + +424 +00:30:36,740 --> 00:30:42,820 +بالعربي هم مابحبوش ياخدوا مخاطر و كمان بدهم مش + +425 +00:30:42,820 --> 00:30:47,620 +يبحثوا .. بدهم مش يبحثوالأنه because if you want + +426 +00:30:47,620 --> 00:30:50,540 +to search on investment it takes time and takes + +427 +00:30:50,540 --> 00:30:55,000 +effort فهو هيحط ال 100 دولار هذه وفي ناس investor + +428 +00:30:55,000 --> 00:30:58,960 +managers مدراء الاستثمار هم هياخدوا ال 100 دولار + +429 +00:30:58,960 --> 00:31:03,340 +تبعته and they invest it on behalf him or her يعني + +430 +00:31:03,340 --> 00:31:05,660 +هيروحوا ياخدوا ال 100 دولار هذه ويروحوا يستثمروا + +431 +00:31:05,660 --> 00:31:11,440 +بالنيابة عنهOkay فهذا السبب وجود ال investment + +432 +00:31:11,440 --> 00:31:14,740 +companies بتاخدوا من الفلوس و الناس هتقول مش فاضي + +433 +00:31:14,740 --> 00:31:17,620 +أتروح وين أودّي ال 100 دولار تبعت هذه أروح أستثمر + +434 +00:31:17,620 --> 00:31:20,540 +في أفريقيا ولا في غانا ولا أستثمر هنا ولا هنا + +435 +00:31:20,540 --> 00:31:23,380 +بيعطوهم إياها and they are responsible to do this + +436 +00:31:23,380 --> 00:31:27,500 +بعدين ال investment companies they can manage risk + +437 +00:31:27,500 --> 00:31:31,680 +هم بيقدروا يديروا المخاطر بشكل أفضل and they have + +438 +00:31:31,680 --> 00:31:34,680 +experience in doing this و عندهم خبرة في هذا + +439 +00:31:34,680 --> 00:31:39,100 +المجالOkay but the insurance companies they invest + +440 +00:31:39,100 --> 00:31:43,680 +to themselves لفلوسهم هي بتظل بتختلف عن ال + +441 +00:31:43,680 --> 00:31:50,320 +investment companies بالظبط + +442 +00:31:50,320 --> 00:31:57,460 +صح هذا مظهر هذا مش هدف أساسي يعني بالظبط مش هدف + +443 +00:31:57,460 --> 00:32:02,000 +الأساسي هي الفائض من بعد عملية التأمين أو سداد + +444 +00:32:02,000 --> 00:32:06,450 +التأمين هم بيروحوا بيعملوا investmentو هذه بنات + +445 +00:32:06,450 --> 00:32:10,010 +يعني ما تستغربوش هدول هم اللي بتحكموا في العالم + +446 +00:32:10,010 --> 00:32:13,950 +كله بتحكموا بالاقتصاد، بتحكموا بالسياسة، بتحكموا + +447 +00:32:13,950 --> 00:32:16,990 +بكل شيء ال small and the big man؟ لأ هدول ال + +448 +00:32:16,990 --> 00:32:21,790 +financial intermediaries هدول إذا كانوا زعلانين، + +449 +00:32:21,790 --> 00:32:25,630 +أه الأمور مابتمشيش أه وإذا كان الأمور هم ماشية + +450 +00:32:25,630 --> 00:32:28,510 +يعني شوفوا لما صار في ال financial crisis وصار ال + +451 +00:32:28,510 --> 00:32:31,390 +financial .. drop in financial intermediaries so + +452 +00:32:31,390 --> 00:32:34,350 +صار في أزمة مالية في العالم okay + +453 +00:32:43,320 --> 00:32:47,060 +طبعا هي مقارنة بين البلوك الاستثمار ومقارنة بين + +454 +00:32:47,060 --> 00:32:56,000 +البلوك التجارية okay + +455 +00:32:56,000 --> 00:33:02,120 +زي ما تشايفين investment banking طبعا هذا حكيته + +456 +00:33:02,120 --> 00:33:05,960 +أثناء الشرح لأن investment banking بيعمل + +457 +00:33:05,960 --> 00:33:08,260 +underwriting ال new stock and bond issue هذا + +458 +00:33:08,260 --> 00:33:14,210 +بيسموه primary marketsسوق الأولى حكيته كيف أي شركة + +459 +00:33:14,210 --> 00:33:17,270 +جديدة بدت تصدر أسهم جديدة أو شركة قائمة بدت تصدر + +460 +00:33:17,270 --> 00:33:20,890 +أسهم جديدة لازم تروح على ال investment banking + +461 +00:33:20,890 --> 00:33:24,210 +sell newly issued securities to public in primary + +462 +00:33:24,210 --> 00:33:27,010 +markets we explained this investors trade + +463 +00:33:27,010 --> 00:33:29,510 +previously issued securities among themselves in + +464 +00:33:29,510 --> 00:33:32,230 +the secondary markets كمان هدول investment banking + +465 +00:33:32,970 --> 00:33:36,410 +لو بدنا نشتري .. أشتري مثلا أسهم شركة بالتل أو + +466 +00:33:36,410 --> 00:33:40,250 +أسهم شركة ال .. شركة بنك فلسطين أو هدول لازم من + +467 +00:33:40,250 --> 00:33:44,210 +خلال هدول الناس ممنوع أنا أروح أتسلفش في .. في سوق + +468 +00:33:44,210 --> 00:33:47,530 +فلسطين مباشرة I have to go through the financial + +469 +00:33:47,530 --> 00:33:50,390 +intermediaries I have to go through the investment + +470 +00:33:50,390 --> 00:33:53,700 +banking or investment companiesال commercial + +471 +00:33:53,700 --> 00:33:56,980 +banking طبعا انتوا حكيتوا فيه بياخد الودائع من + +472 +00:33:56,980 --> 00:34:00,520 +الناس take deposits and make loans بياخدوا من + +473 +00:34:00,520 --> 00:34:04,040 +اليمين و بيعطي الشمال وهو بياخد الفرق بين الفائدة + +474 +00:34:04,040 --> 00:34:09,880 +okay هيك بيكون احنا خلصنا ال chapter oneهذا يعني + +475 +00:34:09,880 --> 00:34:11,560 +just for your .. for your .. for your + +476 +00:34:11,560 --> 00:34:13,560 +understanding, for your culture, for your + +477 +00:34:13,560 --> 00:34:16,780 +knowledge you can read the financial crisis لكن + +478 +00:34:16,780 --> 00:34:21,320 +احنا هذا هو المطلوب عندنا ب chapter one نرجع بس + +479 +00:34:21,320 --> 00:34:24,800 +تلخيص ل chapter one عساس ان احنا نذكركم ايش + +480 +00:34:24,800 --> 00:34:29,260 +المواضيع اللي احنا أخدناها في الفصل هذا عشان انا + +481 +00:34:29,260 --> 00:34:32,420 +اعطيكوا chapter two فان شاء الله on Saturday we + +482 +00:34:32,420 --> 00:34:34,100 +will start in chapter two + +483 +00:34:41,980 --> 00:34:48,160 +أه؟ okay okay + +484 +00:34:48,160 --> 00:34:55,180 +ماشي chapter one just to remind you in chapter one + +485 +00:34:55,180 --> 00:34:57,660 +إيش الأشياء اللي أخدناها ب chapter one + +486 +00:35:01,540 --> 00:35:04,220 +Ihma you have to know what it means investment + +487 +00:35:04,220 --> 00:35:08,420 +environment السؤال الأول تبقى السؤال الأول اللى + +488 +00:35:08,420 --> 00:35:15,180 +موجود عندى على ال website بسأل و بحكي describe in + +489 +00:35:15,180 --> 00:35:17,400 +the light of your understanding of chapter one + +490 +00:35:17,400 --> 00:35:22,100 +describe the investment environment where in + +491 +00:35:22,100 --> 00:35:26,720 +Palestinian authority بدكم تصفولي البيئة + +492 +00:35:26,720 --> 00:35:32,080 +الاستثمارية في مناطق السلطة الفلسطينيةin light of + +493 +00:35:32,080 --> 00:35:35,040 +your understanding بديش تروحوا على ال net و + +494 +00:35:35,040 --> 00:35:40,480 +investment in هذا كلام مابظبطش معناه ايش كاتب انا + +495 +00:35:40,480 --> 00:35:45,920 +in light of your understanding of chapter one معنى + +496 +00:35:45,920 --> 00:35:50,080 +الكلام باجي امسك واحدة واحدة real assets vs + +497 +00:35:50,080 --> 00:35:52,820 +financial assets بشوف ايش ال real assets اللي + +498 +00:35:52,820 --> 00:35:55,420 +موجودة عندنا بالمناطق السلطة و ايش ال financial + +499 +00:35:55,420 --> 00:35:59,680 +assets اللي موجودة okay يعني هذا بيسموه reflection + +500 +00:35:59,680 --> 00:36:04,500 +ايش بنسميهاسمه reflection what it means reflection + +501 +00:36:04,500 --> 00:36:08,660 +يعني احنا الفهم تبعنا بدنا نعمله تطبيق بدنا نطبقه + +502 +00:36:08,660 --> 00:36:13,160 +فال assignment تبعتكوا is reflection بتعمله + +503 +00:36:13,160 --> 00:36:16,500 +reflection of your understanding يعني اذا انا بده + +504 +00:36:16,500 --> 00:36:19,320 +اعرف انه فهمتوا ال chapter ولا لأ if you do the + +505 +00:36:19,320 --> 00:36:22,100 +reflection is fine if you couldn't is you don't + +506 +00:36:22,100 --> 00:36:27,710 +understandOkay فحكينا ال real assets اللي هو + +507 +00:36:27,710 --> 00:36:31,090 +الأصول الحقيقية الأصول الحقيقية هي أصلا بتعمل + +508 +00:36:31,090 --> 00:36:37,750 +بتشجع الإنتاج السلع والخدمات و ال income الدخل و + +509 +00:36:37,750 --> 00:36:41,470 +أعطينا أنثى عليها و الفرق بينها financial asset ال + +510 +00:36:41,470 --> 00:36:44,570 +financial asset هي التزامات على الأصول الثابتة أو + +511 +00:36:44,570 --> 00:36:49,550 +الأصول الحقيقية و حكينا في عندي تلت أنواع من ال + +512 +00:36:49,550 --> 00:36:54,190 +financial assets عندنا ال fixed incomeأصول بتعطيني + +513 +00:36:54,190 --> 00:36:59,390 +عائد ثابت زي .. زي ال .. زي الأسهم الممتازة و زي + +514 +00:36:59,390 --> 00:37:02,970 +السندات ال common stock or OQT الأسهم العادية + +515 +00:37:02,970 --> 00:37:08,730 +بتعطي عوائد غير ثابتة derivatives اللي هو المشتقات + +516 +00:37:08,730 --> 00:37:13,050 +و حكينا عنها ال financial engineering حكينا عنها + +517 +00:37:13,050 --> 00:37:17,930 +الهندسة المالية مش الهندرة الهندسة المالية okay + +518 +00:37:19,500 --> 00:37:23,860 +بعدين دخلنا في تفاصيل وفرحنا بين ال money market و + +519 +00:37:23,860 --> 00:37:26,340 +ال capital market اللي هو السوق النقدي اللي هو + +520 +00:37:26,340 --> 00:37:31,300 +قصير أجل بيكون بيكون ال liquidity عالية فيه بيكون + +521 +00:37:31,300 --> 00:37:35,140 +كمان ال credit risk منخفض ال capital market بيكون + +522 +00:37:35,140 --> 00:37:40,280 +طويل أجل على أمثلته السندات و كمان المخاطر فيه + +523 +00:37:40,280 --> 00:37:46,360 +عالية okay سوق الأسهم و ال derivativesالأسهم هي + +524 +00:37:46,360 --> 00:37:50,640 +حقوق ملكية okay ال derivatives هي اشتقة من ال .. + +525 +00:37:50,640 --> 00:37:55,150 +من ال financial assets okayوحكينا العلاقة بين ال + +526 +00:37:55,150 --> 00:37:58,610 +financial markets و ال economy، دور المعلومات، + +527 +00:37:58,610 --> 00:38:01,630 +المعلومات كل ما زادت كل ما بتحسن أداء السوق، ال + +528 +00:38:01,630 --> 00:38:04,330 +consumption timing لما يكون في عند أوقات أنا + +529 +00:38:04,330 --> 00:38:08,650 +ماعنديش استهلاك، عندي عائد عالي و عندي استهلاك + +530 +00:38:08,650 --> 00:38:12,570 +منخفض، هعمل استثمار للفائض عشان هيجي يوم من الأيام + +531 +00:38:12,570 --> 00:38:17,630 +ماعنديش عائد، okay؟allocation of risk اللي هو + +532 +00:38:17,630 --> 00:38:22,350 +تخصيص المخاطر كيف احنا ممكن نخصص المخاطر كل واحد + +533 +00:38:22,350 --> 00:38:27,330 +مننا له مخاطر محددة وبالتالي في استثمار بيكون + +534 +00:38:27,330 --> 00:38:29,930 +يشابه المخاطر اللي انا بحملها separation of + +535 +00:38:29,930 --> 00:38:32,650 +ownership الفصل في الإدارة الفصل الملكية عن + +536 +00:38:32,650 --> 00:38:36,190 +الإدارة وحكينا عن ال agency problem لأنه لما صار + +537 +00:38:36,190 --> 00:38:38,650 +ففصل الملكية عن الإدارة صار المدرسة يهتموا + +538 +00:38:38,650 --> 00:38:42,270 +بأهدافهم أكتر من أهداف المؤشسة وكيف بنحل الموضوع + +539 +00:38:42,270 --> 00:38:45,910 +حكينا بنحل الموضوع من خلال corporate governanceand + +540 +00:38:45,910 --> 00:38:48,530 +corporate ethics و من خلال أخلاقيات المهنة و + +541 +00:38:48,530 --> 00:38:50,710 +أعطينا أمثلة على ال corporate governance و أمثلة + +542 +00:38:50,710 --> 00:38:55,570 +على ال corporate ethics بسبب عدم تطبيق ال + +543 +00:38:55,570 --> 00:38:58,010 +corporate governance و ال separation صار عندى + +544 +00:38:58,010 --> 00:39:01,410 +scandals فضائح مالية أهم هذا الفضائح مالية شركة + +545 +00:39:01,410 --> 00:39:04,930 +Enron لسبب صارت عندهم مشكلة مع اللي هو Arthur + +546 +00:39:04,930 --> 00:39:08,590 +Anderson انه صار هم بيعملوا auditing and + +547 +00:39:08,590 --> 00:39:11,610 +consultation in the same time استشارات و auditing + +548 +00:39:12,590 --> 00:39:16,310 +بهذا السبب عملوا اللي هو القانون بتاع Sarbanes + +549 +00:39:16,310 --> 00:39:21,670 +-Oxley Act اللي هو بيعمل tightening لل governance + +550 +00:39:21,670 --> 00:39:25,830 +بيأكد و .. و بيشدد على الحوكمة و على ضرورة ال + +551 +00:39:25,830 --> 00:39:28,470 +separation between the auditing services and the + +552 +00:39:28,470 --> 00:39:32,920 +consultancy servicesحكينا عن investment process هي + +553 +00:39:32,920 --> 00:39:37,500 +في three three steps asset allocation تخصيص الأصول + +554 +00:39:37,500 --> 00:39:40,580 +وحكينا عن ال families تبع الأصول بعدين حكينا عن + +555 +00:39:40,580 --> 00:39:44,420 +security selection اختيار الأوراق المالية بعدين ال + +556 +00:39:44,420 --> 00:39:47,140 +security analysis اللي هو تحليل الأوراق المالية + +557 +00:39:47,840 --> 00:39:51,200 +بعدين حكينا عن ال markets and competitive اللي هي + +558 +00:39:51,200 --> 00:39:54,760 +أساسا أنه مافيش إشي ببلاش في السوق، السوق فيه + +559 +00:39:54,760 --> 00:39:58,440 +تنافس فال risk and return trade-off فالمستثمرين + +560 +00:39:58,440 --> 00:40:02,040 +بيعملوا trading-off بين العائد والمخاطر، بعدين + +561 +00:40:02,040 --> 00:40:07,300 +حكينا عن ال efficient marketsالسوق الكافئ و طبعا + +562 +00:40:07,300 --> 00:40:09,820 +السوق الكافئ في عنده strong market, في عنده weak + +563 +00:40:09,820 --> 00:40:12,500 +market و في عنده semi-strong market and we gave + +564 +00:40:12,500 --> 00:40:16,760 +example of these markets وحكينا in the light of + +565 +00:40:16,760 --> 00:40:19,800 +efficient market we have two managements, styles, + +566 +00:40:20,360 --> 00:40:23,120 +the active managements and the passive managements + +567 +00:40:24,120 --> 00:40:27,500 +واليوم حكينا عن the players اللي في السوق المالي + +568 +00:40:27,500 --> 00:40:30,280 +اللي هو business firms, households, governments in + +569 +00:40:30,280 --> 00:40:32,640 +details اللي هم ال financial intermediaries, + +570 +00:40:33,180 --> 00:40:35,520 +investment companies, ال bank, insurance companies + +571 +00:40:35,520 --> 00:40:40,080 +and credit unions هيك بيكون احنا خلصنا ال chapter + +572 +00:40:40,080 --> 00:40:42,200 +one any question؟ + diff --git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_raw.json b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..8616fcc6b3955b60ef95d95e959cbbd21e09353b --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4827, "start": 21.33, "end": 48.27, "text": "طيب احنا نرجع من جديد و نحكي عن ال .. المرة اللي فاتت كنا حكينا عن ال markets and competitives and we talked about risk and return trade-off العلاقة بين العقد و المخاطر و حكينا there is no free lunch مافيش اشي ببلاش okay و بعدين حكينا عن ال .. ال efficient market و حكينا انه في عند نوعين من ال investors", "tokens": [9566, 1829, 3555, 1975, 5016, 8315, 8717, 47341, 3615, 9154, 10874, 16254, 3215, 4032, 8717, 5016, 4117, 1829, 18871, 2423, 4386, 9673, 25720, 13672, 1829, 6156, 9307, 2655, 9122, 8315, 11331, 4117, 1829, 8315, 18871, 2423, 8383, 293, 41131, 1539, 293, 321, 2825, 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"probability": 0.9766845703125}, {"start": 67.27, "end": 67.41, "word": " هذا", "probability": 0.7568359375}, {"start": 67.41, "end": 67.65, "word": " الحاجة", "probability": 0.6448567708333334}, {"start": 67.65, "end": 67.77, "word": " ناقه", "probability": 0.5220947265625}, {"start": 67.77, "end": 67.95, "word": " برضه", "probability": 0.8894856770833334}, {"start": 67.95, "end": 68.23, "word": " المرة", "probability": 0.8427734375}, {"start": 68.23, "end": 68.69, "word": " الفاترة", "probability": 0.6751302083333334}, {"start": 68.69, "end": 69.21, "word": " هلأ", "probability": 0.8987630208333334}, {"start": 69.21, "end": 69.51, "word": " ندخل", "probability": 0.9913330078125}, {"start": 69.51, "end": 69.75, "word": " في", "probability": 0.9599609375}, {"start": 69.75, "end": 70.51, "word": " in", "probability": 0.6884765625}, {"start": 70.51, "end": 70.91, "word": " details", "probability": 0.8505859375}, {"start": 70.91, "end": 71.51, "word": " ندخل", "probability": 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هذا", "probability": 0.97705078125}, {"start": 1894.68, "end": 1895.06, "word": " المجال", "probability": 0.9677734375}], "temperature": 1.0}, {"id": 79, "seek": 192364, "start": 1895.8, "end": 1923.64, "text": "Okay but the insurance companies they invest to themselves لفلوسهم هي بتظل بتختلف عن ال investment companies بالظبط صح هذا مظهر هذا مش هدف أساسي يعني بالظبط مش هدف الأساسي هي الفائض من بعد عملية التأمين أو سداد التأمين هم بيروحوا بيعملوا investment", "tokens": [8297, 457, 264, 7214, 3431, 436, 1963, 281, 2969, 5296, 5172, 1211, 41779, 16095, 39896, 39894, 19913, 1211, 39894, 46456, 46538, 18871, 2423, 6078, 3431, 20666, 19913, 3555, 9566, 20328, 5016, 23758, 3714, 19913, 3224, 2288, 23758, 37893, 8032, 3215, 5172, 5551, 3794, 32277, 1829, 37495, 22653, 20666, 19913, 3555, 9566, 37893, 8032, 3215, 5172, 16247, 3794, 32277, 1829, 39896, 27188, 16373, 11242, 9154, 39182, 6225, 42213, 10632, 16712, 10721, 2304, 9957, 34051, 8608, 3215, 18513, 16712, 10721, 2304, 9957, 8032, 2304, 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"probability": 0.827880859375}, {"start": 2399.4, "end": 2399.96, "word": " بين", "probability": 0.9814453125}, {"start": 2399.96, "end": 2400.44, "word": " العائد", "probability": 0.97705078125}, {"start": 2400.44, "end": 2401.68, "word": " والمخاطر،", "probability": 0.8320719401041666}, {"start": 2401.68, "end": 2402.04, "word": " بعدين", "probability": 0.933837890625}, {"start": 2402.04, "end": 2402.34, "word": " حكينا", "probability": 0.9962158203125}, {"start": 2402.34, "end": 2402.44, "word": " عن", "probability": 0.90625}, {"start": 2402.44, "end": 2402.52, "word": " ال", "probability": 0.8759765625}, {"start": 2402.52, "end": 2402.74, "word": " efficient", "probability": 0.94384765625}, {"start": 2402.74, "end": 2403.34, "word": " markets", "probability": 0.94384765625}], "temperature": 1.0}, {"id": 100, "seek": 242312, "start": 2403.94, "end": 2423.12, "text": "السوق الكافئ و طبعا السوق الكافئ في عنده strong market, في عنده weak market و في عنده semi-strong market and we gave example of these markets وحكينا in the light of efficient market we have two managements, styles, the active managements and the passive managements", "tokens": [6027, 3794, 30543, 33251, 31845, 19986, 4032, 23032, 3555, 3615, 995, 21136, 30543, 33251, 31845, 19986, 8978, 43242, 3224, 2068, 2142, 11, 8978, 43242, 3224, 5336, 2142, 4032, 8978, 43242, 3224, 12909, 12, 28063, 2142, 293, 321, 2729, 1365, 295, 613, 8383, 4032, 5016, 4117, 1829, 8315, 294, 264, 1442, 295, 7148, 2142, 321, 362, 732, 3067, 1117, 11, 13273, 11, 264, 4967, 3067, 1117, 293, 264, 14975, 3067, 1117], "avg_logprob": -0.20543574027612177, "compression_ratio": 1.7228260869565217, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 2403.94, "end": 2404.54, "word": "السوق", "probability": 0.8614908854166666}, {"start": 2404.54, "end": 2404.94, "word": " الكافئ", "probability": 0.6485595703125}, {"start": 2404.94, "end": 2405.66, "word": " و", "probability": 0.75927734375}, {"start": 2405.66, "end": 2407.3, 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"probability": 0.92509765625}, {"start": 2415.5, "end": 2416.06, "word": " in", "probability": 0.9541015625}, {"start": 2416.06, "end": 2416.18, "word": " the", "probability": 0.9365234375}, {"start": 2416.18, "end": 2416.46, "word": " light", "probability": 0.90185546875}, {"start": 2416.46, "end": 2416.76, "word": " of", "probability": 0.98486328125}, {"start": 2416.76, "end": 2417.1, "word": " efficient", "probability": 0.91015625}, {"start": 2417.1, "end": 2417.48, "word": " market", "probability": 0.69580078125}, {"start": 2417.48, "end": 2417.64, "word": " we", "probability": 0.67333984375}, {"start": 2417.64, "end": 2417.82, "word": " have", "probability": 0.9697265625}, {"start": 2417.82, "end": 2418.04, "word": " two", "probability": 0.9140625}, {"start": 2418.04, "end": 2418.66, "word": " managements,", "probability": 0.8447265625}, {"start": 2419.28, "end": 2419.8, "word": " styles,", "probability": 0.89013671875}, {"start": 2420.36, "end": 2420.46, "word": " the", 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--git a/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_raw.srt b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..b7ae4d82d037ec4efd14ca4f48fc1623cc2c024c --- /dev/null +++ b/PL9fwy3NUQKwaXMtLxRSoV_pW-SkLTtZg7/zCSp1vHkyRs_raw.srt @@ -0,0 +1,2324 @@ +1 +00:00:21,330 --> 00:00:25,510 +طيب احنا نرجع من جديد و نحكي عن ال .. المرة اللي + +2 +00:00:25,510 --> 00:00:31,150 +فاتت كنا حكينا عن ال markets and competitives and + +3 +00:00:31,150 --> 00:00:34,510 +we talked about risk and return trade-off العلاقة + +4 +00:00:34,510 --> 00:00:38,130 +بين العقد و المخاطر و حكينا there is no free lunch + +5 +00:00:38,130 --> 00:00:45,010 +مافيش اشي ببلاش okay و بعدين حكينا عن ال .. ال + +6 +00:00:45,010 --> 00:00:47,950 +efficient market و حكينا انه في عند نوعين من ال + +7 +00:00:47,950 --> 00:00:51,670 +investorsفي عندنا active وفي عندنا passive + +8 +00:00:51,670 --> 00:00:55,210 +managers هلأ بنحكي عن ال players in the financial + +9 +00:00:55,210 --> 00:00:59,030 +markets مين هم اللي بيحركوا السوق السوق المالي + +10 +00:00:59,030 --> 00:01:04,430 +عادة في عندنا اللي هم ال business firms, net + +11 +00:01:04,430 --> 00:01:06,370 +borrowers و ال household, net savers و ال + +12 +00:01:06,370 --> 00:01:08,690 +government طبعا هذا الحاجة ناقه برضه المرة الفاترة + +13 +00:01:08,690 --> 00:01:12,030 +هلأ ندخل في in details ندخل في التفاصيل + +14 +00:01:14,840 --> 00:01:18,080 +ال financial intermediaries ايش .. what it means + +15 +00:01:18,080 --> 00:01:22,220 +financial intermediaries احنا + +16 +00:01:22,220 --> 00:01:26,500 +المرة الفاتة حكينا انه ال .. عندي انا هان ال + +17 +00:01:26,500 --> 00:01:30,480 +savers وعندي + +18 +00:01:30,480 --> 00:01:36,760 +.. او عندي ال borrowers اه + +19 +00:01:36,760 --> 00:01:40,500 +المقترضينهلأ مافيشش .. there is no direct relation + +20 +00:01:40,500 --> 00:01:43,380 +between the savers and borrowers مافيش علاقة + +21 +00:01:43,380 --> 00:01:47,760 +مباشرة بين ال savers و ال borrowers يعني مثلا لو + +22 +00:01:47,760 --> 00:01:52,200 +هدول معاهم 100 دولار يعني واحد معاه 100 دولار + +23 +00:01:52,200 --> 00:01:58,250 +ازيادة عن حاجته ايش ممكن يسوي؟المفروض لو فيش + +24 +00:01:58,250 --> 00:02:01,590 +financial intermediaries لو فيش وسطاء ماليين بتروح + +25 +00:02:01,590 --> 00:02:04,230 +يدور على واحد بحاجة لل 100 دولار عشان يعمل + +26 +00:02:04,230 --> 00:02:08,650 +investment طب شوفوا how .. how much time it takes + +27 +00:02:08,650 --> 00:02:12,630 +to look for a one needs of money يعني جداش هو + +28 +00:02:12,630 --> 00:02:19,090 +هيدور على واحد بيحتاج الفلوس هذا واحد اتنين how he + +29 +00:02:19,090 --> 00:02:24,150 +or she wants to secure that his money will back و + +30 +00:02:24,150 --> 00:02:28,810 +كيف هو بيتأكد ان فلوسه هترجعلهكمان شغلة تانية اذا + +31 +00:02:28,810 --> 00:02:33,890 +ال investors or savers face challenges to locate + +32 +00:02:33,890 --> 00:02:38,170 +the borrowers يعني بيواجهوا صعوبات حتى يفتشوا على + +33 +00:02:38,170 --> 00:02:42,090 +ال borrowers so the financial intermediaries + +34 +00:02:42,090 --> 00:02:47,010 +facilitate the relationship between savers and + +35 +00:02:47,010 --> 00:02:52,710 +borrowers فهم موجودين بالمنطقة هذه ال financial + +36 +00:02:52,710 --> 00:02:59,770 +intermediariesFinancial intermediaries، FI، الهدف + +37 +00:02:59,770 --> 00:03:01,910 +الرئيسي للهدف الانتقال الانتقال الانتقال الانتقال + +38 +00:03:01,910 --> 00:03:03,170 +الانتقال الانتقال الانتقال الانتقال الانتقال + +39 +00:03:03,170 --> 00:03:04,030 +الانتقال الانتقال الانتقال الانتقال الانتقال + +40 +00:03:04,030 --> 00:03:06,130 +الانتقال الانتقال الانتقال الانتقال الانتقال + +41 +00:03:06,130 --> 00:03:06,510 +الانتقال الانتقال الانتقال الانتقال الانتقال + +42 +00:03:06,510 --> 00:03:06,510 +الانتقال الانتقال الانتقل الانتقل الانتقل الانتقل + +43 +00:03:06,510 --> 00:03:10,770 +الانتقل الانتقل الانتقل الانتقل الانتقل الانتقل + +44 +00:03:10,770 --> 00:03:15,830 +الانتقل الانتقل + +45 +00:03:15,830 --> 00:03:20,900 +الانتقل الانتقل الانتو بالعكس مثلا احنا هلا دفعنا + +46 +00:03:20,900 --> 00:03:24,020 +المية دولار دفعناهم لل borowers and the borowers + +47 +00:03:24,020 --> 00:03:27,740 +they invest the one hundred dollar and later on + +48 +00:03:27,740 --> 00:03:30,160 +they have to pay back the one hundred dollar to + +49 +00:03:30,160 --> 00:03:36,040 +the savers so this is why take the savers pay to + +50 +00:03:36,040 --> 00:03:40,760 +the borowers and borowers pay for the savers take + +51 +00:03:40,760 --> 00:03:47,020 +like this chartSo this is the flow of .. of funds + +52 +00:03:47,020 --> 00:03:55,080 +from the savers to the borrowers okay ال savers + +53 +00:03:55,080 --> 00:04:02,300 +اللي معاهمه فلوس ال borrowers + +54 +00:04:02,300 --> 00:04:06,620 +اللي هو أحمد مانفلنبان صح احنا مافي نشوف ال savers + +55 +00:04:06,620 --> 00:04:11,890 +مافي نشوف اللي هو الإبانيزرyes يعني هال ال + +56 +00:04:11,890 --> 00:04:17,170 +intermediaries الشركات الوساطة الوساطاء الماليين + +57 +00:04:17,170 --> 00:04:20,650 +هم بيعملوا facilitate لل relationship between the + +58 +00:04:20,650 --> 00:04:24,110 +servers and borrowers يعني ممكن تمثلوا الكلام هذا + +59 +00:04:24,110 --> 00:04:27,830 +يعني يكون في ناس معهم فلوس موجودين على الجانب + +60 +00:04:27,830 --> 00:04:30,410 +اليمين و ناس اللي معهم مش فلوس موجودين على الجانب + +61 +00:04:30,410 --> 00:04:34,540 +اليسار هدول لإنهم بيعرفوش بعضbecause they don't + +62 +00:04:34,540 --> 00:04:37,920 +know each other so the .. the financial + +63 +00:04:37,920 --> 00:04:42,800 +intermediaries facilitate the relationship between + +64 +00:04:42,800 --> 00:04:46,860 +the savers and the borrowers طب مين هم ال + +65 +00:04:46,860 --> 00:04:50,320 +financial intermediaries؟ this is the question مين + +66 +00:04:50,320 --> 00:04:53,380 +هم ال financial intermediaries؟ ال financial + +67 +00:04:53,380 --> 00:04:59,310 +intermediariesOkay banks خلّيني أشوف هم مين يعني + +68 +00:04:59,310 --> 00:05:04,790 +هم بتحكي ال banks okay banks okay مين كمان البنوك + +69 +00:05:04,790 --> 00:05:08,890 +investment companies investment companies + +70 +00:05:08,890 --> 00:05:12,230 +companies + +71 +00:05:12,230 --> 00:05:16,450 +credit unions إيش يعني credit unions + +72 +00:05:19,330 --> 00:05:24,570 +اه اتحادات الاعتمان او الشركات الاعتمانية الشركات + +73 +00:05:24,570 --> 00:05:29,630 +اللي بتقدم الاعتمان بيسموها credit union بتقدر + +74 +00:05:29,630 --> 00:05:34,630 +تعطوني مثال عليهم دول credit unions لأ تأمين هذي + +75 +00:05:34,630 --> 00:05:40,910 +الشركة تأمينممكن اه ممكن أصالة فاتن save children + +76 +00:05:40,910 --> 00:05:47,050 +okay مين كمان انيرة مثلا US aid ال honor one كمان + +77 +00:05:47,050 --> 00:05:54,130 +ممكن تقدم ال unicef شوفتوا هدول ممكن trade .. ممكن + +78 +00:05:54,130 --> 00:05:57,170 +إغاثة كاتوليكية كمان تشتغل الشغل هاد فهدول بيسموهم + +79 +00:05:57,170 --> 00:06:03,070 +trade unions مؤسسات بتقدم اقتراض او بتقدم اقتمال + +80 +00:06:03,070 --> 00:06:09,570 +لل .. لل .. لل porvosال insurance companies؟ + +81 +00:06:09,570 --> 00:06:14,630 +الشركات التأمين؟ اه مين بيعرف كيف شركات التأمين + +82 +00:06:14,630 --> 00:06:20,790 +بتشتغل؟ يالا كيف شركات التأمين بتعمل .. بتاخد من + +83 +00:06:20,790 --> 00:06:23,870 +ال savers و بتعطي ل ال borrowers؟ عن طريق السلحات + +84 +00:06:23,870 --> 00:06:26,670 +التأمين اللي بيبقى ياخد الاصابيين .. بالظبط .. + +85 +00:06:26,670 --> 00:06:31,770 +الشركة فإن ما يحصل إنه حادث .. هتقوم معاهم إيش؟ + +86 +00:06:32,380 --> 00:06:35,960 +يعني انت .. انت مثلا you are saving كل شهر تدفع + +87 +00:06:35,960 --> 00:06:41,400 +فلوس كأقصاد تأمين لشركة و later on in the future + +88 +00:06:41,400 --> 00:06:45,920 +في المستقبل لما الواحد يتقاعد بياخد الفلوس هذه في + +89 +00:06:45,920 --> 00:06:46,400 +المستقبل + +90 +00:06:49,270 --> 00:06:51,730 +يعني اللي بيروح عليك تقنية و اللي بيروح أكثر تقنية + +91 +00:06:51,730 --> 00:06:56,210 +بيروح عليك يدهد .. يدهد الأمار يعطيها لأشخاص تانية + +92 +00:06:56,210 --> 00:07:00,070 +يستفيدوا منها يستفيدوا منها okay صحيح اذا زي ما + +93 +00:07:00,070 --> 00:07:04,370 +تشايفين investment companies شركات الاستثمار شركات + +94 +00:07:04,370 --> 00:07:09,070 +الاستثمار هاي بت .. مهمتها انه تكوين شغل اسمها ال + +95 +00:07:09,070 --> 00:07:11,250 +martial funds martial + +96 +00:07:13,010 --> 00:07:17,750 +funds نحكي عن marital funds كمان مهمتهم managing + +97 +00:07:17,750 --> 00:07:18,630 +the portfolios + +98 +00:07:21,770 --> 00:07:24,330 +إدارة المحافظة الاستثمارية يعني mutual funds + +99 +00:07:24,330 --> 00:07:27,730 +صناديق الاستثمار ال portfolios اللي هو محافظ + +100 +00:07:27,730 --> 00:07:31,670 +الاستثمار ايش يعني ال mutual funds الصناديق + +101 +00:07:31,670 --> 00:07:35,370 +الاستثمار هي صناديق ضخمة جدا يعني ممكن يكون يصل + +102 +00:07:35,370 --> 00:07:40,070 +لعشرين لمية مليون دولار جاي هذا الصناديق من + +103 +00:07:40,070 --> 00:07:44,450 +استثمارات الناس الناس العاديين يعني مثلا لو شخص + +104 +00:07:44,450 --> 00:07:48,250 +معاه مية دولار هذا الشخص اللي معاه مية دولار بده + +105 +00:07:48,250 --> 00:07:49,630 +يدخل في الصناديق الاستثمار + +106 +00:07:52,840 --> 00:07:56,320 +بروح بتصل في ال investment companies اللي هو شركات + +107 +00:07:56,320 --> 00:07:59,920 +الاستثمار شركات الاستثمار هذه عاملة صناديق هذه + +108 +00:07:59,920 --> 00:08:02,740 +الصناديق هتم الاستثمار فيها مثلا في أوروبا في + +109 +00:08:02,740 --> 00:08:06,920 +أفريقيا في دول معينة فبحطول ال 100 دولار في هذا + +110 +00:08:06,920 --> 00:08:12,740 +الصندوق يعني كأنه فيها صندوق okay و بتيجي بحطوا ال + +111 +00:08:12,740 --> 00:08:16,560 +100 دولار في هذا الصندوق طبعا millions of people + +112 +00:08:16,560 --> 00:08:21,430 +ملايين الناس هيحطوا في هذا الصندوقOkay يعني هتيجي + +113 +00:08:21,430 --> 00:08:29,150 +لناس كتير يساهموا في هذا الصندوق لنفترض انه صار + +114 +00:08:29,150 --> 00:08:34,430 +قيمة الصندوق five million يتم + +115 +00:08:34,430 --> 00:08:40,090 +تحويل الوحدات بالدولار إلى أسهم في الصندوق هو بتاع + +116 +00:08:40,090 --> 00:08:43,870 +اللي بيحكوا كل مية دولار بتساوي سهم واحد أو وحدة + +117 +00:08:43,870 --> 00:08:46,830 +واحدة بلاش نحكي أسهم بلاش نخربط مع الأسهم وحدة + +118 +00:08:46,830 --> 00:08:51,260 +واحدة لو عندي خمسة مليون دولارخمسة مليون دولار + +119 +00:08:51,260 --> 00:08:57,440 +أكمل وحدة بيصيروا نحكي خمسة مليون تقسيم مية دولار + +120 +00:08:57,440 --> 00:09:01,760 +الوحدة الواحدة تساوي مية دولار فبطلع قيمة الوحدات + +121 +00:09:01,760 --> 00:09:05,540 +اللي في الصندوق هلأ كيف بيحسبوا الربح و الخسارة؟ + +122 +00:09:06,510 --> 00:09:11,090 +الوحدات هذه لها سعر وليكن نبدأ في bar value 100$ + +123 +00:09:11,090 --> 00:09:16,170 +الbar value يعني قيمة الإسمية 100$ بتبدأ أسعار + +124 +00:09:16,170 --> 00:09:20,570 +الوحدة ترتفع و تنخفض في السوق المالي وبناء عليه هي + +125 +00:09:20,570 --> 00:09:25,880 +تم حساب الربح والخسارةهذه الصناديق مغلقة قد تكون + +126 +00:09:25,880 --> 00:09:30,440 +صناديق سنوية يعني يتم فتح الصندوق او انهاء الصندوق + +127 +00:09:30,440 --> 00:09:34,000 +مع نهاية السنة و بيشوفوا كام ربح الصندوق عادة هذه + +128 +00:09:34,000 --> 00:09:38,480 +الصناديق بتعمل long term investments استثمارات + +129 +00:09:38,480 --> 00:09:41,280 +طويلة أجل عادة بيروحوا مثلا بيستثمروا في أفريقيا + +130 +00:09:41,280 --> 00:09:43,760 +بيفتحوا شركات مثلا في أفريقيا بيروحوا مثلا + +131 +00:09:43,760 --> 00:09:47,400 +بالمكسيك بيروحوا بيعملوا شغل بالمكسيك و هاي يعني + +132 +00:09:47,400 --> 00:09:49,200 +بتكون long term investment شوفوا ال 100 دولار + +133 +00:09:49,200 --> 00:09:53,590 +تبعتكماللي انتوا دفعتوها اشي بسيط لكن هذه ال 100 + +134 +00:09:53,590 --> 00:09:57,350 +دولار حطت فى صندوق استثمار وراحت فتحت شركات ضخمة + +135 +00:09:57,350 --> 00:10:01,250 +فى العالم فيعني don't underestimate the importance + +136 +00:10:01,250 --> 00:10:05,310 +of your 100 دولار يعني ما .. ما تستهنوش فى ال 100 + +137 +00:10:05,310 --> 00:10:07,650 +دولار اللي انتوا بتدفعوها دول because they do big + +138 +00:10:07,650 --> 00:10:12,450 +investments using the .. the mutual funds ال + +139 +00:10:12,450 --> 00:10:21,590 +portfolios المحافظة الاستثمارية هي عبارة عناستثمار + +140 +00:10:21,590 --> 00:10:27,650 +متنوع في عدة مجالات okay يعني احنا عندنا هان + +141 +00:10:27,650 --> 00:10:31,890 +خلّيني نرجع لفكرة ال mutual funds ال mutual funds + +142 +00:10:31,890 --> 00:10:39,370 +بشمل عدة محافظ استثمارية حطينا ال 100 دولار في هاي + +143 +00:10:39,370 --> 00:10:43,230 +ال mutual funds ال mutual funds حكينا بشمل على 5 + +144 +00:10:43,230 --> 00:10:49,950 +مليون دولار في استثمارات في أفريقيا مثلافي + +145 +00:10:49,950 --> 00:10:53,790 +استثمارات مثلا في الماكسيك ففي أفريقيا بنروح + +146 +00:10:53,790 --> 00:10:56,610 +بنستثمر في محفظة استثمارية في أفريقيا محفظة + +147 +00:10:56,610 --> 00:10:59,810 +استثمارية يعني portfolios إذا المواتشال funds + +148 +00:10:59,810 --> 00:11:04,270 +includes many or different portfolios مجموعة من + +149 +00:11:04,270 --> 00:11:07,710 +محافظات استثمارية والمحفظة الاستثمارية الواحدة + +150 +00:11:07,710 --> 00:11:13,050 +بتشمل كمان بتشمل عدة استثمارات يعني مثلا in Africa + +151 +00:11:13,050 --> 00:11:15,830 +ممكن احنا نعمل investment في ال communication + +152 +00:11:18,440 --> 00:11:22,300 +Okay ممكن نعمل investment في ال .. في ال + +153 +00:11:22,300 --> 00:11:27,600 +infrastructure في ال .. يعني في ال .. في البنية + +154 +00:11:27,600 --> 00:11:30,340 +التحتية و ممكن نعمل investment مثلا في ال + +155 +00:11:30,340 --> 00:11:36,940 +nutrition في التخزين يعني مثلا بتعرفوا مثلا في + +156 +00:11:36,940 --> 00:11:43,040 +الصومال فيه بتواجههم مشكلة الصومال إيش أهم إنتاج + +157 +00:11:43,040 --> 00:11:48,180 +في الصومال عندهم؟لأ أهم إنتاج منتج استراتيجي عندهم + +158 +00:11:48,180 --> 00:11:51,940 +قالتنا الموز الموز اه + +159 +00:11:55,410 --> 00:11:59,110 +اه فبيحتاج .. فمن أكبر المنتجين للموز في العالم هم + +160 +00:11:59,110 --> 00:12:04,630 +الصومال فهدول لإنهم ما عندهمش إمكانيات ي .. يروحوا + +161 +00:12:04,630 --> 00:12:08,230 +يخطفوا الموز و يحطوه في حويات و الحويات تنقلهم + +162 +00:12:08,230 --> 00:12:11,390 +لأنحاء العالم بدون .. تحتاج طائرات و بتحتاج + +163 +00:12:11,390 --> 00:12:15,990 +لإمكانيات ضخمة للاستثمار فبصير تم تشكيل محافظة + +164 +00:12:15,990 --> 00:12:22,840 +استثمارية تعمل استثمارات بنقل ال .. المحصوليعني + +165 +00:12:22,840 --> 00:12:28,260 +بيكون عبارة .. okay بيكون عبارة عن عمليات النقل + +166 +00:12:28,260 --> 00:12:35,220 +بحتاجه لوسائل نقل متقدمة بحيث تحافظ على ال .. نضج + +167 +00:12:35,220 --> 00:12:39,060 +الموز نفسه، عدم التلف للموز، بيحتاج إلى ثلاجات + +168 +00:12:39,060 --> 00:12:42,900 +معينة بخصائص معينة حتى لما ينقل بالطائرات يكون له + +169 +00:12:42,900 --> 00:12:47,750 +خصائص معينة وبالتاليلأنه في .. في مناطق الفقر هذه + +170 +00:12:47,750 --> 00:12:51,170 +مابحتاجوا .. مابقدروش يغطوا هذه المجالات ففي + +171 +00:12:51,170 --> 00:12:54,210 +صناديق استثمار بتروح تعمل استثمارات في أفريقيا و + +172 +00:12:54,210 --> 00:12:59,210 +في المكسيك و في بعض الدول في آسيا حتى يروحوا ي .. + +173 +00:12:59,210 --> 00:13:05,250 +طبعا استفادتهم انه استفادة ..ليست بسيطة طبعا هم + +174 +00:13:05,250 --> 00:13:08,910 +بيشتريوا الموز بأسعار معينة و بيبيعوا الموز بأسعار + +175 +00:13:08,910 --> 00:13:12,490 +أعلى وهذا بيعطيهم فرص استثمارية عالية جدا okay هاي + +176 +00:13:12,490 --> 00:13:17,210 +أمثلة عن كيف ان هم ممكن هم they invest في ال .. في + +177 +00:13:17,210 --> 00:13:19,770 +ال mutual funds and invest in the portfolios في + +178 +00:13:19,770 --> 00:13:24,050 +المحافظة الاستثمارية اذا الصندوق الاستثمار ال + +179 +00:13:24,050 --> 00:13:27,750 +mutual funds بيشمل عدة محافظة استثمارية ممكن + +180 +00:13:27,750 --> 00:13:31,110 +هيحكينا Africa ممكن هم يستهمروا مثلا بال .. بال + +181 +00:13:31,110 --> 00:13:37,210 +energyفي ال middle east في الشرق الأوسط بيستثمروا + +182 +00:13:37,210 --> 00:13:39,610 +في ال energy في ال middle east لو احنا جينا و جينا + +183 +00:13:39,610 --> 00:13:42,070 +على شاط بحر غزا هن .. هنشوف اللي هو ال British + +184 +00:13:42,070 --> 00:13:45,230 +petroleum اللي هو شركة .. شركة البريطانية هذه ال + +185 +00:13:45,230 --> 00:13:50,530 +.. okay اللي هو استخراج الغاز فهذا بيكون عبارة عن + +186 +00:13:50,530 --> 00:13:55,130 +شركات استثمار عملت investment فتحت محفظ استثمارية + +187 +00:13:55,130 --> 00:13:57,630 +أو صندوق استثمار و عملت investment في .. في هذا + +188 +00:13:57,630 --> 00:14:03,540 +المجالOkay فيعني هذا دور المحافظة الاستثمارية + +189 +00:14:03,540 --> 00:14:09,380 +صناديخ الاستثمار بتوفر كتير فلوس لل investors او + +190 +00:14:09,380 --> 00:14:12,340 +لل bourgeois يعني زي ما حكينا ال one hundred + +191 +00:14:12,340 --> 00:14:16,020 +dollar هادي لما تكون من مليون واحد فتصوروا ميت + +192 +00:14:16,020 --> 00:14:20,160 +مليون بيصير لو كل واحد شهريا دفع just one hundred + +193 +00:14:20,160 --> 00:14:24,550 +dollarو and invest in these mutual funds so it + +194 +00:14:24,550 --> 00:14:28,470 +means the business will grow up هي .. هي ال + +195 +00:14:28,470 --> 00:14:31,870 +business يزيد و يصير توسع و يصير نمو لكن لو أجينا + +196 +00:14:31,870 --> 00:14:34,210 +احنا ال 100 hundred دولار تبعتنا شوفوا الفرق بين + +197 +00:14:34,210 --> 00:14:38,550 +the rule of financial intermediaries and if there + +198 +00:14:38,550 --> 00:14:41,170 +is no financial intermediaries اذا كان عندي + +199 +00:14:41,170 --> 00:14:44,250 +financial intermediaries و لو ماكنش ال 100 .. ال + +200 +00:14:44,250 --> 00:14:46,870 +100 دولار هذي اللي معايا بقدر أنه أروح فيها على + +201 +00:14:46,870 --> 00:14:49,950 +أفريقيا أعمل investments طب بقدر أعمل secret + +202 +00:14:49,950 --> 00:14:55,390 +hadithبقدر أعمل مثلا أنجل الموز من الصومال لانحاء + +203 +00:14:55,390 --> 00:14:59,210 +العالم بقدر مثلا أعمل investment في ال energy مثلا + +204 +00:14:59,210 --> 00:15:03,230 +بالعالم it's impossible so the one hundred dollar + +205 +00:15:03,230 --> 00:15:06,830 +this one hundred dollar make the mutual funds and + +206 +00:15:06,830 --> 00:15:11,460 +mutual funds invest over all the worldهذا ال .. + +207 +00:15:11,460 --> 00:15:13,820 +فعشان هي واحد بتسأل من وين المصاري millions of + +208 +00:15:13,820 --> 00:15:16,020 +dollars من وين جاي هالواحد بيمتلكهم؟ لأ because + +209 +00:15:16,020 --> 00:15:19,700 +mutual funds is considered as a units وحدات زي ما + +210 +00:15:19,700 --> 00:15:24,640 +حكينا وحدة من الدولار and it's collected from the + +211 +00:15:24,640 --> 00:15:26,800 +servers هدول ال servers اللي معاهم اللي ميتهندروا + +212 +00:15:26,800 --> 00:15:31,600 +الدولار حطوها ب .. معال .. مع ال investment + +213 +00:15:31,600 --> 00:15:34,300 +companies و ال investment .. investment companies + +214 +00:15:34,300 --> 00:15:36,780 +they channel it to the borrowers و ال borrowers + +215 +00:15:36,780 --> 00:15:40,040 +راحوا يعملوا investment big .. big investment في + +216 +00:15:40,040 --> 00:15:43,900 +around the world okay فتتفاجأوش لما تكون الشركة + +217 +00:15:43,900 --> 00:15:48,020 +مثلا عندها trillion of dollar هذي trillion of + +218 +00:15:48,020 --> 00:15:51,060 +dollar is coming from the small investors جاي من + +219 +00:15:51,060 --> 00:15:57,180 +ال small investors لزهار استثماراتيعني مثلا لو + +220 +00:15:57,180 --> 00:16:02,140 +احنا فكرنا مثلا نشتغل مثلا شركة، نعمل شركة + +221 +00:16:02,140 --> 00:16:06,500 +استثمارات في خطاعة غزة و .. و هذه رقم اسمها thirty + +222 +00:16:06,500 --> 00:16:10,240 +million، تلاتين مليون دولار و الناس بيقول oh wow + +223 +00:16:10,240 --> 00:16:15,140 +thirty millions how we can get this numberممكن + +224 +00:16:15,140 --> 00:16:18,480 +نجيب الرقم هذا بسهولة تلاتين مليون ممكن نجابه + +225 +00:16:18,480 --> 00:16:21,760 +بسهولة من خلال ال .. ال .. ال investors ال savers + +226 +00:16:21,760 --> 00:16:26,580 +ال savers مش شرط one saver have thirty million مش + +227 +00:16:26,580 --> 00:16:30,060 +شرط ال .. ال .. المستثمر الواحد او المدخل الواحد + +228 +00:16:30,060 --> 00:16:33,900 +يكون عنده تلاتين مليون ممكن هذا يكون مية دولار هذا + +229 +00:16:33,900 --> 00:16:37,000 +متين دولار هذا الف دولار at the end of the day we + +230 +00:16:37,000 --> 00:16:42,550 +will have the three hundred دولارمثلا في عندنا + +231 +00:16:42,550 --> 00:16:45,790 +مثلا بدون ذكر أسماء البنوك يعني في عندنا بنك من + +232 +00:16:45,790 --> 00:16:50,870 +البنوك بيعمل في غزة الودائع المقيمين في قطاع غزة + +233 +00:16:50,870 --> 00:16:54,750 +four billion مش four million four billion يعني + +234 +00:16:54,750 --> 00:16:58,110 +أربع مليارات دولارات دولار الضفة الغربي وقطع غزة + +235 +00:16:58,110 --> 00:17:03,510 +بس في بنك واحد عندهم أربع مليار دولارات ودائع فلو + +236 +00:17:03,510 --> 00:17:05,810 +احنا بدنا نفكر نفتح شركة just for thirty million + +237 +00:17:05,810 --> 00:17:10,580 +يعني نقدر احنا نفتح عشر شركاتأو نفتحنا 15 شركة من + +238 +00:17:10,580 --> 00:17:13,880 +ال big companies على مستوى الدفع الغربي و الخدعازة + +239 +00:17:13,880 --> 00:17:17,400 +شوفوا كيف ممكن احنا نعمل to change our investments + +240 +00:17:17,400 --> 00:17:21,280 +from the just depositing the bank into + +241 +00:17:21,280 --> 00:17:25,880 +industrialized investments لإن استثمارات صناعية و + +242 +00:17:25,880 --> 00:17:30,300 +استثمارات خدماتية okay هذا ال investment companies + +243 +00:17:30,300 --> 00:17:34,280 +لو حكينا على ال banks على البنوك we have different + +244 +00:17:34,280 --> 00:17:38,830 +banksفي عندنا بنوك مختلفة ممكن تعطونا إيش أسماء .. + +245 +00:17:38,830 --> 00:17:42,250 +إيش البنوك ال .. لأ بديش أسماء بنوك بدي أنواع + +246 +00:17:42,250 --> 00:17:49,950 +البنوك فضل بنك المركزي the central bank إيش ال + +247 +00:17:49,950 --> 00:17:57,050 +central bank هذا شغلته هو is بتعرفي .. بتعرفي أب + +248 +00:17:57,050 --> 00:18:02,130 +البنوك he is the bank of banks أو or the father of + +249 +00:18:02,130 --> 00:18:07,600 +banks هو أب البنوكis .. is organizing and + +250 +00:18:07,600 --> 00:18:11,840 +observing okay and managing the other banks or the + +251 +00:18:11,840 --> 00:18:15,120 +commercial and other banks يعني هو بدير .. اه عفوا + +252 +00:18:15,120 --> 00:18:19,860 +هو بي .. بيراقب و بتابع و بنظم عمليات البنوك نفسها + +253 +00:18:19,860 --> 00:18:23,640 +controlling them طب هذا ال central bank غير ال + +254 +00:18:23,640 --> 00:18:29,070 +central bank مين؟ البناية الوراأه غير ال central + +255 +00:18:29,070 --> 00:18:31,370 +bank اتفضلى .. commercial bank .. commercial bank + +256 +00:18:31,370 --> 00:18:32,270 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +257 +00:18:32,270 --> 00:18:32,450 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +258 +00:18:32,450 --> 00:18:33,910 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +259 +00:18:33,910 --> 00:18:33,930 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +260 +00:18:33,930 --> 00:18:35,230 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +261 +00:18:35,230 --> 00:18:40,170 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +262 +00:18:40,170 --> 00:18:42,910 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +263 +00:18:42,910 --> 00:18:42,910 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +264 +00:18:42,910 --> 00:18:42,910 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +265 +00:18:42,910 --> 00:18:42,910 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +266 +00:18:42,910 --> 00:18:42,910 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +267 +00:18:42,910 --> 00:18:46,250 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +268 +00:18:46,250 --> 00:18:48,010 +ال .. ال .. ال + +269 +00:18:51,990 --> 00:18:55,450 +أيوة في .. في investment banks بس ال investment + +270 +00:18:55,450 --> 00:18:58,470 +banks خدوا بالكم مش هو ال investment banks اللي + +271 +00:18:58,470 --> 00:19:02,710 +احنا بنعرفه investment banks له شغل بختلف عن شغل + +272 +00:19:02,710 --> 00:19:07,990 +البنك التجاري البنك الاستثمار مهمته انه يشجع + +273 +00:19:07,990 --> 00:19:13,770 +الاستثمار okay يعني مثلا ي .. زي بنوك الصناعية + +274 +00:19:13,770 --> 00:19:20,060 +يروح مثلا يوجه الأموال تبعته نحو الصناعاتOkay يوجه + +275 +00:19:20,060 --> 00:19:24,260 +الأموال تبعته في تمويل الشركات و خاصة في شغل اسمها + +276 +00:19:24,260 --> 00:19:29,240 +primary .. primary markets + +277 +00:19:31,580 --> 00:19:34,560 +Okay primary market تذكروا هذا المصطلح primary + +278 +00:19:34,560 --> 00:19:40,260 +markets هو is in charge is in charge to do the + +279 +00:19:40,260 --> 00:19:43,760 +primary markets البنك الاستثمار هو المسئول عن + +280 +00:19:43,760 --> 00:19:47,260 +عملية ال primary market اللي هو سوق الأصدارات + +281 +00:19:47,260 --> 00:19:50,620 +الأولية يعني أيه سوق الأصدارات الأولية؟ لما الشركة + +282 +00:19:50,620 --> 00:19:54,760 +.. أول شركة ما تنتشق بتحتاج تترح أسهم وين بتترح + +283 +00:19:54,760 --> 00:19:58,040 +الأسهم هذه؟ لازم تترحها في بنك الاستثمار احنا في + +284 +00:19:58,040 --> 00:20:02,300 +القطاع الغزة أو في الضفة الغربي يعني هذا الدورلأنه + +285 +00:20:02,300 --> 00:20:06,120 +ماعناش professional investment banks ماعناش بنوك + +286 +00:20:06,120 --> 00:20:10,520 +استثمار استثمارات احترافية او متخصصة فبلجأوا + +287 +00:20:10,520 --> 00:20:14,540 +للبنوك التجارية حتى يقوموا بهذا الدور وهذا اشي غلط + +288 +00:20:14,540 --> 00:20:18,720 +يصير بال .. لأن دور البنك الاستثمار هو دور يختلف + +289 +00:20:18,720 --> 00:20:21,760 +عن دور البنوك التجارية so be careful in the role + +290 +00:20:21,760 --> 00:20:25,120 +of commercial banks and the role of investment + +291 +00:20:25,120 --> 00:20:27,620 +banks ايش كمان عن الألوان من البنوك؟ + +292 +00:20:30,560 --> 00:20:34,600 +البنوك المتخصصة specialized bank زي ايش مثلا + +293 +00:20:34,600 --> 00:20:39,420 +specialized bank الزراعي بالظبط زي مثلا لو روحنا + +294 +00:20:39,420 --> 00:20:43,580 +احنا على مصر specialized bank هنلاقي اللي هو ال + +295 +00:20:43,580 --> 00:20:47,520 +بنك الاقتمام الزراعي بنك الاقتمام الزراعي هو بنك + +296 +00:20:47,520 --> 00:20:51,300 +متخصص just to invest in the agriculture areas هو + +297 +00:20:51,300 --> 00:20:55,020 +بس متخصصين بال agriculture اللي هو في الزراعة okay + +298 +00:20:55,020 --> 00:21:01,020 +فهذا البنوك بتتخصص بهذا المجالفي مثلا ال housing + +299 +00:21:01,020 --> 00:21:06,260 +bank housing bank بنوك ال .. ال .. الاسكان و بنوك + +300 +00:21:06,260 --> 00:21:10,060 +ال real estate هذه مهمتها إيش؟ to .. to channel + +301 +00:21:10,060 --> 00:21:13,820 +the funds to the housing investments اللي هو بناء + +302 +00:21:13,820 --> 00:21:17,960 +البيوت و بناء المنازل و بناء الطرقات فهم بتخصصين + +303 +00:21:17,960 --> 00:21:23,420 +بهذا المجال okay إيش في عندك بنوك؟ Islamic bank + +304 +00:21:23,420 --> 00:21:25,100 +طبعا Islamic bank + +305 +00:21:29,190 --> 00:21:32,410 +لأ ما بتستخدم القلول ال Islamic part بيستخدموا + +306 +00:21:32,410 --> 00:21:36,910 +المرابحة و المضاربة و المشاركة okay فعندهم + +307 +00:21:36,910 --> 00:21:39,430 +المضاربة و المرابحة و المشاركة + +308 +00:21:42,060 --> 00:21:45,480 +لأ هم ما بيستخدموا القروض هم بيستخدموا يعني + +309 +00:21:45,480 --> 00:21:48,960 +بيستخدموا أدوات استثمارية بتختلف ممكن يكون .. ممكن + +310 +00:21:48,960 --> 00:21:53,420 +يكون ال investors من برا يشوف أنه مافيش اختلاف لكن + +311 +00:21:53,420 --> 00:21:56,760 +ال process فعلا هي في اختلاف لما بدك تاخد مرابحة + +312 +00:21:56,760 --> 00:22:01,900 +مثلا بتطلب أنه مايكونش .. يعني مايكونش ملكية الشئ + +313 +00:22:01,900 --> 00:22:07,120 +تكون للبنك فالبنك بيعمل عقد مع الشركة السيارات و + +314 +00:22:07,120 --> 00:22:10,860 +من ثم بيتم بيع السيارة من البنك ل .. ل هذا الشخص + +315 +00:22:11,620 --> 00:22:16,860 +Okay فهذا اختلف صحيح انه شكلا ممكن يكون متشابه لكن + +316 +00:22:16,860 --> 00:22:21,340 +مضمونا لأ فيه اختلاف وبتساهل احنا في ال .. و هيك + +317 +00:22:21,340 --> 00:22:25,000 +يعني الفرق بين .. بين ال .. بين اي شي حلال او اي + +318 +00:22:25,000 --> 00:22:28,660 +.. او اي شي محرم هو .. هو الشعر البسيط انه ال .. + +319 +00:22:28,660 --> 00:22:35,530 +ال .. اللي بتسير في المضمون تبعهالعملية نفسها ففي + +320 +00:22:35,530 --> 00:22:37,650 +عندنا البنوك الإسلامية البنوك الإسلامية لأ في + +321 +00:22:37,650 --> 00:22:40,350 +عندها المرابحة وفي عندنا المضاربة وفي عندنا + +322 +00:22:40,350 --> 00:22:42,730 +المشاركة وفي عندنا الاستثمار المتخصص وفي عندنا + +323 +00:22:42,730 --> 00:22:46,990 +الاستثمار اه كل هذا طبعا بتوفره البنوك الإسلامية + +324 +00:22:46,990 --> 00:22:50,690 +والبنوك الإسلامية اليوم كتير متطورة حتى يعني بنوك + +325 +00:22:50,690 --> 00:22:54,830 +أجنبية زي ال HSBC Bank HSBC Bank تاني أكبر بنك في + +326 +00:22:54,830 --> 00:23:01,380 +العالم بيقدم خدمات إسلامية بيسميها Amana Bankأمانة + +327 +00:23:01,380 --> 00:23:06,740 +بنك امانة بنك اللي هي خدمات استثمارية pure islamic + +328 +00:23:06,740 --> 00:23:10,440 +طبعا pure islamic يعني اسلامية مية في المية مافيش + +329 +00:23:10,440 --> 00:23:13,940 +فيها مشاكل بتاخد مرابحة بتاخد مضاربة بتاخد + +330 +00:23:13,940 --> 00:23:18,480 +استثمارات الوداق مافيش فيها عليها الفوائد اللي + +331 +00:23:18,480 --> 00:23:21,900 +الفوائد الربوية وبالتالي there is a spreading out + +332 +00:23:21,900 --> 00:23:26,920 +to the concept of islamic banking طبعا هذا بالنسبة + +333 +00:23:26,920 --> 00:23:32,950 +للبنوكبقى موجود .. هذا موجود في .. في لندن، في + +334 +00:23:32,950 --> 00:23:36,690 +بريطانيا و ال .. أصلا ال headquarter موجود في هونج + +335 +00:23:36,690 --> 00:23:42,050 +كونج لإن هو إجا بين اندماج لعدة .. لبن كين تمام؟ + +336 +00:23:42,050 --> 00:23:46,350 +اللي هو هونج كونج بانك فهذا ال .. البنك يعتبر تاني + +337 +00:23:46,350 --> 00:23:49,490 +أكبر بنك في العالم بعد دوتش بانكالدوتش بانك في + +338 +00:23:49,490 --> 00:23:53,670 +عنده 450 ألف .. دوتش بانك لأ .. دوتش بانك ألماني + +339 +00:23:53,670 --> 00:23:57,970 +.. بانك ألماني .. اه ف .. هذا ال بانك اللي هو دوتش + +340 +00:23:57,970 --> 00:24:03,850 +بانك عنده تقريبا ما يزيد عن 450 ألف موظفين موزعين + +341 +00:24:03,850 --> 00:24:08,610 +على أنحاء العالم وبالتالي يعني .. هذه البنوك + +342 +00:24:08,610 --> 00:24:13,520 +العالمية تقدم خدمات إسلاميةو اليوم في توجه كبير + +343 +00:24:13,520 --> 00:24:18,920 +لتقديم محافظ استثمارية إسلامية و قروض إستثمارية + +344 +00:24:18,920 --> 00:24:24,860 +إسلامية وهي ما يعني صارت توجه العالم بتقديم بعض + +345 +00:24:24,860 --> 00:24:30,800 +الخدمات الإسلامية okay ال insurance companies + +346 +00:24:30,800 --> 00:24:35,000 +حكينا فيهم بخدمة خدمات التأمينو هدول بيعتمدوا على + +347 +00:24:35,000 --> 00:24:38,300 +علم اسمه actuarials actuaries اللي هو علم + +348 +00:24:38,300 --> 00:24:42,260 +الاكتواريات علم الاكتواريات كتير بيستخدموا + +349 +00:24:42,260 --> 00:24:49,440 +الاحتمالات علم الاكتواريات actuarials اللي هو علم + +350 +00:24:49,440 --> 00:24:50,380 +الاكتواريات + +351 +00:25:01,110 --> 00:25:04,310 +Science هذا علم الاكتواريات بيستخدم كتير + +352 +00:25:04,310 --> 00:25:10,290 +الاحتمالات .. اه الاحتمالات و .. و نسبة ال .. نسبة + +353 +00:25:10,290 --> 00:25:14,710 +حدوث الحدث و نسبة الحوادث و كذا حتى يروح يحسب و + +354 +00:25:14,710 --> 00:25:19,690 +أخاط التأمين على ال investors تمام؟ + +355 +00:25:20,250 --> 00:25:23,090 +ال credit unions حكينا عندهم أمثلة كبيرة ل credit + +356 +00:25:23,090 --> 00:25:26,750 +unions اللي هو أن المؤسسات التأمين أو اتحادات + +357 +00:25:26,750 --> 00:25:30,350 +التأمين و البنات هتعطيطوني عدة أمثلة اعطوني مثلا + +358 +00:25:30,350 --> 00:25:38,080 +زي credit unions مثلا أصالع فاتن مين كمان أنااه + +359 +00:25:38,080 --> 00:25:43,260 +الإغاثة الإسلامية يعني يقدموا قروض ميسرة okay و + +360 +00:25:43,260 --> 00:25:48,180 +بيتم المستثمرين بي .. طب السؤال هدول مثلا زي أصالة + +361 +00:25:48,180 --> 00:25:51,540 +و فاتن و ال .. و أنيرة و save ال children و هذا من + +362 +00:25:51,540 --> 00:25:56,680 +وين بيجيبوا الأموال تبعتهم؟اه من .. من ال savers + +363 +00:25:56,680 --> 00:25:59,960 +.. من ال savers هدول international savers بروحوا ب + +364 +00:25:59,960 --> 00:26:05,280 +.. بستثمروا في هذه المؤسسات على أساس أنه ي .. يعني + +365 +00:26:05,280 --> 00:26:10,200 +يقوموا بعملية تنمية معينة في دول مثلا دول فقيرة + +366 +00:26:10,200 --> 00:26:16,480 +حتى يستطيعوا ينهضوا بال .. بالاقتصاد okay أي سؤال + +367 +00:26:16,480 --> 00:26:20,580 +على ال credit unions أو سؤال على ال financial + +368 +00:26:20,580 --> 00:26:21,580 +intermediaries + +369 +00:26:26,560 --> 00:26:31,260 +لأ ال insurance companies هم شركات تأمين يعني + +370 +00:26:31,260 --> 00:26:34,960 +مابعملوش ال insurance companies هدول بيقدموش + +371 +00:26:34,960 --> 00:26:40,320 +تسهيلات اقتمانية خد بالك ال competition هو يعني + +372 +00:26:40,320 --> 00:26:42,740 +كويس ان انت سألت السؤال هذا ان ال competition + +373 +00:26:42,740 --> 00:26:46,500 +بيكون بين ال insurance companies و ال investment + +374 +00:26:46,500 --> 00:26:52,350 +companies في نوع من منافسة بيناتهملما احنا نروح + +375 +00:26:52,350 --> 00:26:55,770 +ندفع أقصاد التأمين فبصير pool شوفوا انتوا من كلمة + +376 +00:26:55,770 --> 00:27:00,930 +pool pool and invest فشركات التأمين أكبر الشركات + +377 +00:27:00,930 --> 00:27:04,610 +اللي عندها saving لإنه كنا بندفع أقصاد تأمين + +378 +00:27:04,610 --> 00:27:09,170 +السيارة أقصاد تأمين المنازل أقصاد تأمين الحياة + +379 +00:27:09,170 --> 00:27:13,750 +تأمين العمال فبتدخل ايش؟ بتدخل هذه عبارة عن funds + +380 +00:27:13,750 --> 00:27:19,170 +هذه ال funds بحتاج لإيش؟ بحتاج ل channel ان احنا + +381 +00:27:19,170 --> 00:27:24,040 +نعمل investmentsفبدل ما يوجهوا هذا ال funds ل + +382 +00:27:24,040 --> 00:27:27,180 +investment companies by themselves invest this + +383 +00:27:27,180 --> 00:27:29,320 +money وعدم ان they play + +384 +00:27:32,600 --> 00:27:36,700 +a huge role in the capital markets يعني هذا + +385 +00:27:36,700 --> 00:27:40,860 +بيلعبوا دور كبير في النظام الرأسمالي هم بيأثروا ال + +386 +00:27:40,860 --> 00:27:43,740 +.. ال entrance companies هم the main players in + +387 +00:27:43,740 --> 00:27:46,060 +the .. in the financial markets هم اللي بيلعبوا + +388 +00:27:46,060 --> 00:27:48,940 +دور كبير في ال financial markets ف instead of + +389 +00:27:48,940 --> 00:27:52,510 +channel the money or the funds to theinvestment + +390 +00:27:52,510 --> 00:27:55,430 +companies they do it by themselves فممكن ما + +391 +00:27:55,430 --> 00:27:58,270 +تتفاجأوش ان ال insurance companies هم يروحوا + +392 +00:27:58,270 --> 00:28:00,430 +يعملوا investment في أفريقا و ممكن يعملوا + +393 +00:28:00,430 --> 00:28:02,590 +investment في ال .. في ال united states و في ال UK + +394 +00:28:02,590 --> 00:28:05,350 +في ال middle east بال .. بال .. بال European + +395 +00:28:05,350 --> 00:28:07,690 +countries so they don't have problems in investing + +396 +00:28:07,690 --> 00:28:11,130 +as long as they have the funds لأنهم عندهم الفلوس + +397 +00:28:11,130 --> 00:28:16,000 +و بالتالي they can do it by themselvesواضح الكلام + +398 +00:28:16,000 --> 00:28:19,260 +فال insurance companies مش بس هم they serving or + +399 +00:28:19,260 --> 00:28:23,800 +they provide insurance services but they provide + +400 +00:28:23,800 --> 00:28:27,020 +investment services فهم كمان بيروحوا بيعملوا + +401 +00:28:27,020 --> 00:28:32,120 +استثمارات هم اللي بياخدوا أقصاد التأمين من الناس + +402 +00:28:32,120 --> 00:28:37,100 +بيعملوا investment لهاي بيستثمروها في أماكن مختلفة + +403 +00:28:37,100 --> 00:28:42,630 +في العالمو هدول يعني هتلاق .. هتجدهم من مالكين + +404 +00:28:42,630 --> 00:28:45,590 +أكبر شركات في العالم هدول ال insurance companies + +405 +00:28:45,590 --> 00:28:49,610 +okay and they have a good experience in managing + +406 +00:28:49,610 --> 00:28:53,390 +other companies و عندهم خبرات كبيرة عالية جدا في + +407 +00:28:53,390 --> 00:29:00,830 +ان هم إدارة الشركات الغير تأمينية okay مكتوب كمان + +408 +00:29:00,830 --> 00:29:03,410 +بالكتاب المماشي البنك او ال .. + +409 +00:29:10,240 --> 00:29:18,580 +بس ال insurance + +410 +00:29:18,580 --> 00:29:22,840 +companies مابيعملوش الكلام هذا يعني مش شغلتهم انه + +411 +00:29:22,840 --> 00:29:26,520 +ياخدوا saving هم شغلتهم ايش؟ شغلتهم ياخدوا أقصاد + +412 +00:29:26,520 --> 00:29:31,060 +التأمين اللي هو بيسموها insurance installments + +413 +00:29:31,060 --> 00:29:34,520 +أقصاد التأمين اسمها insurance installments + +414 +00:29:42,520 --> 00:29:47,700 +فعشان هيك صحيح كلامك أنه مش هم أكبر ناس اللي + +415 +00:29:47,700 --> 00:29:50,860 +يعملوا intermediaries between the savers and + +416 +00:29:50,860 --> 00:29:54,240 +investors بط هم أكتر ناس اللي يعملوا investments + +417 +00:29:54,240 --> 00:29:57,820 +هم و مين؟ هم و ال investment companies هم و شركات + +418 +00:29:57,820 --> 00:30:04,290 +الاستثمارال .. ال .. ال .. ال .. ال .. ال .. ال .. + +419 +00:30:04,290 --> 00:30:04,530 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +420 +00:30:04,530 --> 00:30:04,690 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +421 +00:30:04,690 --> 00:30:05,470 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +422 +00:30:05,470 --> 00:30:06,290 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +423 +00:30:06,290 --> 00:30:10,130 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +424 +00:30:10,130 --> 00:30:12,670 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +425 +00:30:12,670 --> 00:30:12,670 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +426 +00:30:12,670 --> 00:30:13,050 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +427 +00:30:13,050 --> 00:30:13,050 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +428 +00:30:13,050 --> 00:30:13,050 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +429 +00:30:13,050 --> 00:30:13,310 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +430 +00:30:13,310 --> 00:30:13,310 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +431 +00:30:13,310 --> 00:30:21,890 +ال .. ال .. ال .. + +432 +00:30:31,700 --> 00:30:36,740 +Okay ال .. الناس اللي بيروحوا اللي هم ناس يعني + +433 +00:30:36,740 --> 00:30:42,820 +بالعربي هم مابحبوش ياخدوا مخاطر و كمان بدهم مش + +434 +00:30:42,820 --> 00:30:47,620 +يبحثوا .. بدهم مش يبحثوالأنه because if you want + +435 +00:30:47,620 --> 00:30:50,540 +to search on investment it takes time and takes + +436 +00:30:50,540 --> 00:30:55,000 +effort فهو هيحط ال 100 دولار هذه وفي ناس investor + +437 +00:30:55,000 --> 00:30:58,960 +managers مدراء الاستثمار هم هياخدوا ال 100 دولار + +438 +00:30:58,960 --> 00:31:03,340 +تبعته and they invest it on behalf him or her يعني + +439 +00:31:03,340 --> 00:31:05,660 +هيروحوا ياخدوا ال 100 دولار هذه ويروحوا يستثمروا + +440 +00:31:05,660 --> 00:31:11,440 +بالنيابة عنهOkay فهذا السبب وجود ال investment + +441 +00:31:11,440 --> 00:31:14,740 +companies بتاخدوا من الفلوس و الناس هتقول مش فاضي + +442 +00:31:14,740 --> 00:31:17,620 +أتروح وين أودّي ال 100 دولار تبعت هذه أروح أستثمر + +443 +00:31:17,620 --> 00:31:20,540 +في أفريقيا ولا في غانا ولا أستثمر هنا ولا هنا + +444 +00:31:20,540 --> 00:31:23,380 +بيعطوهم إياها and they are responsible to do this + +445 +00:31:23,380 --> 00:31:27,500 +بعدين ال investment companies they can manage risk + +446 +00:31:27,500 --> 00:31:31,680 +هم بيقدروا يديروا المخاطر بشكل أفضل and they have + +447 +00:31:31,680 --> 00:31:34,680 +experience in doing this و عندهم خبرة في هذا + +448 +00:31:34,680 --> 00:31:39,100 +المجالOkay but the insurance companies they invest + +449 +00:31:39,100 --> 00:31:43,680 +to themselves لفلوسهم هي بتظل بتختلف عن ال + +450 +00:31:43,680 --> 00:31:50,320 +investment companies بالظبط + +451 +00:31:50,320 --> 00:31:57,460 +صح هذا مظهر هذا مش هدف أساسي يعني بالظبط مش هدف + +452 +00:31:57,460 --> 00:32:02,000 +الأساسي هي الفائض من بعد عملية التأمين أو سداد + +453 +00:32:02,000 --> 00:32:06,450 +التأمين هم بيروحوا بيعملوا investmentو هذه بنات + +454 +00:32:06,450 --> 00:32:10,010 +يعني ما تستغربوش هدول هم اللي بتحكموا في العالم + +455 +00:32:10,010 --> 00:32:13,950 +كله بتحكموا بالاقتصاد، بتحكموا بالسياسة، بتحكموا + +456 +00:32:13,950 --> 00:32:16,990 +بكل شيء ال small and the big man؟ لأ هدول ال + +457 +00:32:16,990 --> 00:32:21,790 +financial intermediaries هدول إذا كانوا زعلانين، + +458 +00:32:21,790 --> 00:32:25,630 +أه الأمور مابتمشيش أه وإذا كان الأمور هم ماشية + +459 +00:32:25,630 --> 00:32:28,510 +يعني شوفوا لما صار في ال financial crisis وصار ال + +460 +00:32:28,510 --> 00:32:31,390 +financial .. drop in financial intermediaries so + +461 +00:32:31,390 --> 00:32:34,350 +صار في أزمة مالية في العالم okay + +462 +00:32:43,320 --> 00:32:47,060 +طبعا هي مقارنة بين البلوك الاستثمار ومقارنة بين + +463 +00:32:47,060 --> 00:32:56,000 +البلوك التجارية okay + +464 +00:32:56,000 --> 00:33:02,120 +زي ما تشايفين investment banking طبعا هذا حكيته + +465 +00:33:02,120 --> 00:33:05,960 +أثناء الشرح لأن investment banking بيعمل + +466 +00:33:05,960 --> 00:33:08,260 +underwriting ال new stock and bond issue هذا + +467 +00:33:08,260 --> 00:33:14,210 +بيسموه primary marketsسوق الأولى حكيته كيف أي شركة + +468 +00:33:14,210 --> 00:33:17,270 +جديدة بدت تصدر أسهم جديدة أو شركة قائمة بدت تصدر + +469 +00:33:17,270 --> 00:33:20,890 +أسهم جديدة لازم تروح على ال investment banking + +470 +00:33:20,890 --> 00:33:24,210 +sell newly issued securities to public in primary + +471 +00:33:24,210 --> 00:33:27,010 +markets we explained this investors trade + +472 +00:33:27,010 --> 00:33:29,510 +previously issued securities among themselves in + +473 +00:33:29,510 --> 00:33:32,230 +the secondary markets كمان هدول investment banking + +474 +00:33:32,970 --> 00:33:36,410 +لو بدنا نشتري .. أشتري مثلا أسهم شركة بالتل أو + +475 +00:33:36,410 --> 00:33:40,250 +أسهم شركة ال .. شركة بنك فلسطين أو هدول لازم من + +476 +00:33:40,250 --> 00:33:44,210 +خلال هدول الناس ممنوع أنا أروح أتسلفش في .. في سوق + +477 +00:33:44,210 --> 00:33:47,530 +فلسطين مباشرة I have to go through the financial + +478 +00:33:47,530 --> 00:33:50,390 +intermediaries I have to go through the investment + +479 +00:33:50,390 --> 00:33:53,700 +banking or investment companiesال commercial + +480 +00:33:53,700 --> 00:33:56,980 +banking طبعا انتوا حكيتوا فيه بياخد الودائع من + +481 +00:33:56,980 --> 00:34:00,520 +الناس take deposits and make loans بياخدوا من + +482 +00:34:00,520 --> 00:34:04,040 +اليمين و بيعطي الشمال وهو بياخد الفرق بين الفائدة + +483 +00:34:04,040 --> 00:34:09,880 +okay هيك بيكون احنا خلصنا ال chapter oneهذا يعني + +484 +00:34:09,880 --> 00:34:11,560 +just for your .. for your .. for your + +485 +00:34:11,560 --> 00:34:13,560 +understanding, for your culture, for your + +486 +00:34:13,560 --> 00:34:16,780 +knowledge you can read the financial crisis لكن + +487 +00:34:16,780 --> 00:34:21,320 +احنا هذا هو المطلوب عندنا ب chapter one نرجع بس + +488 +00:34:21,320 --> 00:34:24,800 +تلخيص ل chapter one عساس ان احنا نذكركم ايش + +489 +00:34:24,800 --> 00:34:29,260 +المواضيع اللي احنا أخدناها في الفصل هذا عشان انا + +490 +00:34:29,260 --> 00:34:32,420 +اعطيكوا chapter two فان شاء الله on Saturday we + +491 +00:34:32,420 --> 00:34:34,100 +will start in chapter two + +492 +00:34:41,980 --> 00:34:48,160 +أه؟ okay okay + +493 +00:34:48,160 --> 00:34:55,180 +ماشي chapter one just to remind you in chapter one + +494 +00:34:55,180 --> 00:34:57,660 +إيش الأشياء اللي أخدناها ب chapter one + +495 +00:35:01,540 --> 00:35:04,220 +Ihma you have to know what it means investment + +496 +00:35:04,220 --> 00:35:08,420 +environment السؤال الأول تبقى السؤال الأول اللى + +497 +00:35:08,420 --> 00:35:15,180 +موجود عندى على ال website بسأل و بحكي describe in + +498 +00:35:15,180 --> 00:35:17,400 +the light of your understanding of chapter one + +499 +00:35:17,400 --> 00:35:22,100 +describe the investment environment where in + +500 +00:35:22,100 --> 00:35:26,720 +Palestinian authority بدكم تصفولي البيئة + +501 +00:35:26,720 --> 00:35:32,080 +الاستثمارية في مناطق السلطة الفلسطينيةin light of + +502 +00:35:32,080 --> 00:35:35,040 +your understanding بديش تروحوا على ال net و + +503 +00:35:35,040 --> 00:35:40,480 +investment in هذا كلام مابظبطش معناه ايش كاتب انا + +504 +00:35:40,480 --> 00:35:45,920 +in light of your understanding of chapter one معنى + +505 +00:35:45,920 --> 00:35:50,080 +الكلام باجي امسك واحدة واحدة real assets vs + +506 +00:35:50,080 --> 00:35:52,820 +financial assets بشوف ايش ال real assets اللي + +507 +00:35:52,820 --> 00:35:55,420 +موجودة عندنا بالمناطق السلطة و ايش ال financial + +508 +00:35:55,420 --> 00:35:59,680 +assets اللي موجودة okay يعني هذا بيسموه reflection + +509 +00:35:59,680 --> 00:36:04,500 +ايش بنسميهاسمه reflection what it means reflection + +510 +00:36:04,500 --> 00:36:08,660 +يعني احنا الفهم تبعنا بدنا نعمله تطبيق بدنا نطبقه + +511 +00:36:08,660 --> 00:36:13,160 +فال assignment تبعتكوا is reflection بتعمله + +512 +00:36:13,160 --> 00:36:16,500 +reflection of your understanding يعني اذا انا بده + +513 +00:36:16,500 --> 00:36:19,320 +اعرف انه فهمتوا ال chapter ولا لأ if you do the + +514 +00:36:19,320 --> 00:36:22,100 +reflection is fine if you couldn't is you don't + +515 +00:36:22,100 --> 00:36:27,710 +understandOkay فحكينا ال real assets اللي هو + +516 +00:36:27,710 --> 00:36:31,090 +الأصول الحقيقية الأصول الحقيقية هي أصلا بتعمل + +517 +00:36:31,090 --> 00:36:37,750 +بتشجع الإنتاج السلع والخدمات و ال income الدخل و + +518 +00:36:37,750 --> 00:36:41,470 +أعطينا أنثى عليها و الفرق بينها financial asset ال + +519 +00:36:41,470 --> 00:36:44,570 +financial asset هي التزامات على الأصول الثابتة أو + +520 +00:36:44,570 --> 00:36:49,550 +الأصول الحقيقية و حكينا في عندي تلت أنواع من ال + +521 +00:36:49,550 --> 00:36:54,190 +financial assets عندنا ال fixed incomeأصول بتعطيني + +522 +00:36:54,190 --> 00:36:59,390 +عائد ثابت زي .. زي ال .. زي الأسهم الممتازة و زي + +523 +00:36:59,390 --> 00:37:02,970 +السندات ال common stock or OQT الأسهم العادية + +524 +00:37:02,970 --> 00:37:08,730 +بتعطي عوائد غير ثابتة derivatives اللي هو المشتقات + +525 +00:37:08,730 --> 00:37:13,050 +و حكينا عنها ال financial engineering حكينا عنها + +526 +00:37:13,050 --> 00:37:17,930 +الهندسة المالية مش الهندرة الهندسة المالية okay + +527 +00:37:19,500 --> 00:37:23,860 +بعدين دخلنا في تفاصيل وفرحنا بين ال money market و + +528 +00:37:23,860 --> 00:37:26,340 +ال capital market اللي هو السوق النقدي اللي هو + +529 +00:37:26,340 --> 00:37:31,300 +قصير أجل بيكون بيكون ال liquidity عالية فيه بيكون + +530 +00:37:31,300 --> 00:37:35,140 +كمان ال credit risk منخفض ال capital market بيكون + +531 +00:37:35,140 --> 00:37:40,280 +طويل أجل على أمثلته السندات و كمان المخاطر فيه + +532 +00:37:40,280 --> 00:37:46,360 +عالية okay سوق الأسهم و ال derivativesالأسهم هي + +533 +00:37:46,360 --> 00:37:50,640 +حقوق ملكية okay ال derivatives هي اشتقة من ال .. + +534 +00:37:50,640 --> 00:37:55,150 +من ال financial assets okayوحكينا العلاقة بين ال + +535 +00:37:55,150 --> 00:37:58,610 +financial markets و ال economy، دور المعلومات، + +536 +00:37:58,610 --> 00:38:01,630 +المعلومات كل ما زادت كل ما بتحسن أداء السوق، ال + +537 +00:38:01,630 --> 00:38:04,330 +consumption timing لما يكون في عند أوقات أنا + +538 +00:38:04,330 --> 00:38:08,650 +ماعنديش استهلاك، عندي عائد عالي و عندي استهلاك + +539 +00:38:08,650 --> 00:38:12,570 +منخفض، هعمل استثمار للفائض عشان هيجي يوم من الأيام + +540 +00:38:12,570 --> 00:38:17,630 +ماعنديش عائد، okay؟allocation of risk اللي هو + +541 +00:38:17,630 --> 00:38:22,350 +تخصيص المخاطر كيف احنا ممكن نخصص المخاطر كل واحد + +542 +00:38:22,350 --> 00:38:27,330 +مننا له مخاطر محددة وبالتالي في استثمار بيكون + +543 +00:38:27,330 --> 00:38:29,930 +يشابه المخاطر اللي انا بحملها separation of + +544 +00:38:29,930 --> 00:38:32,650 +ownership الفصل في الإدارة الفصل الملكية عن + +545 +00:38:32,650 --> 00:38:36,190 +الإدارة وحكينا عن ال agency problem لأنه لما صار + +546 +00:38:36,190 --> 00:38:38,650 +ففصل الملكية عن الإدارة صار المدرسة يهتموا + +547 +00:38:38,650 --> 00:38:42,270 +بأهدافهم أكتر من أهداف المؤشسة وكيف بنحل الموضوع + +548 +00:38:42,270 --> 00:38:45,910 +حكينا بنحل الموضوع من خلال corporate governanceand + +549 +00:38:45,910 --> 00:38:48,530 +corporate ethics و من خلال أخلاقيات المهنة و + +550 +00:38:48,530 --> 00:38:50,710 +أعطينا أمثلة على ال corporate governance و أمثلة + +551 +00:38:50,710 --> 00:38:55,570 +على ال corporate ethics بسبب عدم تطبيق ال + +552 +00:38:55,570 --> 00:38:58,010 +corporate governance و ال separation صار عندى + +553 +00:38:58,010 --> 00:39:01,410 +scandals فضائح مالية أهم هذا الفضائح مالية شركة + +554 +00:39:01,410 --> 00:39:04,930 +Enron لسبب صارت عندهم مشكلة مع اللي هو Arthur + +555 +00:39:04,930 --> 00:39:08,590 +Anderson انه صار هم بيعملوا auditing and + +556 +00:39:08,590 --> 00:39:11,610 +consultation in the same time استشارات و auditing + +557 +00:39:12,590 --> 00:39:16,310 +بهذا السبب عملوا اللي هو القانون بتاع Sarbanes + +558 +00:39:16,310 --> 00:39:21,670 +-Oxley Act اللي هو بيعمل tightening لل governance + +559 +00:39:21,670 --> 00:39:25,830 +بيأكد و .. و بيشدد على الحوكمة و على ضرورة ال + +560 +00:39:25,830 --> 00:39:28,470 +separation between the auditing services and the + +561 +00:39:28,470 --> 00:39:32,920 +consultancy servicesحكينا عن investment process هي + +562 +00:39:32,920 --> 00:39:37,500 +في three three steps asset allocation تخصيص الأصول + +563 +00:39:37,500 --> 00:39:40,580 +وحكينا عن ال families تبع الأصول بعدين حكينا عن + +564 +00:39:40,580 --> 00:39:44,420 +security selection اختيار الأوراق المالية بعدين ال + +565 +00:39:44,420 --> 00:39:47,140 +security analysis اللي هو تحليل الأوراق المالية + +566 +00:39:47,840 --> 00:39:51,200 +بعدين حكينا عن ال markets and competitive اللي هي + +567 +00:39:51,200 --> 00:39:54,760 +أساسا أنه مافيش إشي ببلاش في السوق، السوق فيه + +568 +00:39:54,760 --> 00:39:58,440 +تنافس فال risk and return trade-off فالمستثمرين + +569 +00:39:58,440 --> 00:40:02,040 +بيعملوا trading-off بين العائد والمخاطر، بعدين + +570 +00:40:02,040 --> 00:40:07,300 +حكينا عن ال efficient marketsالسوق الكافئ و طبعا + +571 +00:40:07,300 --> 00:40:09,820 +السوق الكافئ في عنده strong market, في عنده weak + +572 +00:40:09,820 --> 00:40:12,500 +market و في عنده semi-strong market and we gave + +573 +00:40:12,500 --> 00:40:16,760 +example of these markets وحكينا in the light of + +574 +00:40:16,760 --> 00:40:19,800 +efficient market we have two managements, styles, + +575 +00:40:20,360 --> 00:40:23,120 +the active managements and the passive managements + +576 +00:40:24,120 --> 00:40:27,500 +واليوم حكينا عن the players اللي في السوق المالي + +577 +00:40:27,500 --> 00:40:30,280 +اللي هو business firms, households, governments in + +578 +00:40:30,280 --> 00:40:32,640 +details اللي هم ال financial intermediaries, + +579 +00:40:33,180 --> 00:40:35,520 +investment companies, ال bank, insurance companies + +580 +00:40:35,520 --> 00:40:40,080 +and credit unions هيك بيكون احنا خلصنا ال chapter + +581 +00:40:40,080 --> 00:40:42,200 +one any question؟ + diff --git a/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/-hNgaZ_BRLc_raw.srt b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/-hNgaZ_BRLc_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..3dfab19286105c692810404e2bbe0dd22225f441 --- /dev/null +++ b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/-hNgaZ_BRLc_raw.srt @@ -0,0 +1,960 @@ +1 +00:00:03,240 --> 00:00:05,860 +بسم الله الرحمن الرحيم الصلاة والسلام علي سيدنا + +2 +00:00:05,860 --> 00:00:09,960 +محمد سيد المرسلين وعلي أهلي وصحبي أجمعين محارتنا + +3 +00:00:09,960 --> 00:00:16,680 +اليوم الخامسة في مساق ال biomechanics two هتكون + +4 +00:00:16,680 --> 00:00:21,340 +موضوعنا عن ال biomechanics of articular cartilage + +5 +00:00:21,340 --> 00:00:28,820 +وإحنا زي ما إحنا شايفين بالرسم التوضيحي أمامنا ال + +6 +00:00:28,820 --> 00:00:33,940 +cartilage هو عبارة عن سطح أملسموجود بين الـ two + +7 +00:00:33,940 --> 00:00:38,640 +adjacent bone اللي بيشكله ال joint و بتعمل عملية + +8 +00:00:38,640 --> 00:00:44,800 +تقليل الاحتكاك ما بين المفصل و هو ال articular + +9 +00:00:44,800 --> 00:00:48,720 +cartilage كمان مافيش فيه sensation عشان هيك احنا + +10 +00:00:48,720 --> 00:00:52,120 +مابنحسش في القلم الا اذا صار فيه تأكل في هذا ال + +11 +00:00:52,120 --> 00:00:55,900 +cartilage و كمان مافيش فيه vascularization عشان + +12 +00:00:55,900 --> 00:01:02,200 +هيك فعندهش قدرة على ال regeneration مرة تانيةال + +13 +00:01:02,200 --> 00:01:06,500 +articular cartilage هو عبارة عن highly specialized + +14 +00:01:06,500 --> 00:01:11,400 +class of connective tissue with high mechanical + +15 +00:01:11,400 --> 00:01:12,320 +properties + +16 +00:01:31,390 --> 00:01:36,130 +movement it is intention even no stress is present + +17 +00:01:36,130 --> 00:01:43,390 +و عادة بيكون ال .. ال cartilage مشنود عادة بي .. + +18 +00:01:43,390 --> 00:01:48,880 +بيقاوم ال compressive و ال shear forcesوكمان في + +19 +00:01:48,880 --> 00:01:52,000 +نفس الوقت بيتمتع بحاجة اسمة resilience and + +20 +00:01:52,000 --> 00:01:56,000 +elasticity بالمرونة اللي الكافية لإن هو عنده قدرة + +21 +00:01:56,000 --> 00:02:00,100 +على امتصاص ال energy و release كمان لل energy + +22 +00:02:00,100 --> 00:02:03,120 +معناه كلمة resilience is the ability of the + +23 +00:02:03,120 --> 00:02:08,790 +material to absorbenergy when it is deformed with + +24 +00:02:08,790 --> 00:02:14,330 +deformed ال elast .. يعني .. يعني لما بيصير فيه ال + +25 +00:02:14,330 --> 00:02:18,290 +.. عملية ال deformation أو التغيير على الشكل بعد + +26 +00:02:18,290 --> 00:02:21,850 +هيك بعد ما يروح ال compression بيصير release وهدي + +27 +00:02:21,850 --> 00:02:27,190 +لل energy إذا صار في unloading طيب إيش ال types of + +28 +00:02:27,190 --> 00:02:31,110 +ال cartilage؟ هي عندنا الhyaline cartilage اللي هو + +29 +00:02:31,110 --> 00:02:34,640 +ال most common typeموجود في ال synovial joint و ال + +30 +00:02:34,640 --> 00:02:38,700 +freely movable .. movable joint و هو عبارة عن طبقة + +31 +00:02:38,700 --> 00:02:44,760 +من ال .. خلينا نقول .. + +32 +00:02:49,290 --> 00:02:56,930 +هو طبقة ملساق موجودة تكون تقريبا حوالي مواحدة خمسة + +33 +00:02:56,930 --> 00:03:03,710 +ملي من ال .. ال white layers of connective tissue + +34 +00:03:03,710 --> 00:03:09,330 +بتكون موجودة ما بين أسطح ال .. ال articular .. ال + +35 +00:03:09,330 --> 00:03:15,040 +joints على أساس بتمنع الاحتكاكو في عندنا ال + +36 +00:03:15,040 --> 00:03:19,400 +elastic cartilage هو ال .. ال cartilage اللي موجود + +37 +00:03:19,400 --> 00:03:22,860 +حوالين ال external ear و في عندنا كمان ال + +38 +00:03:22,860 --> 00:03:27,560 +fibrocartilage اللي هو عبارة عن ال cartilage اللي + +39 +00:03:27,560 --> 00:03:33,720 +موجود على ال .. حوالين ال annulus فيبروسز في ال + +40 +00:03:33,720 --> 00:03:37,330 +intervertebral discوكمان موجود في ال meniscus of + +41 +00:03:37,330 --> 00:03:42,070 +the knee اللي هي عبارة عن pads او مخدات موجودة + +42 +00:03:42,070 --> 00:03:46,370 +بتزود ال congruence تبع اني joinedطبعا إيش وظيفة + +43 +00:03:46,370 --> 00:03:52,050 +ال articular cartilage وظيفته أول حاجة هو self + +44 +00:03:52,050 --> 00:03:55,570 +-lubricants أو self-lubricating تشيوه بيعمل عملية + +45 +00:03:55,570 --> 00:03:59,930 +ال lubrication أو التشحيم أو تزييد تبعت المفصل + +46 +00:03:59,930 --> 00:04:04,750 +إحنا بنعرف أي مفصل إذا كان قلت التشحيم اللي فيه + +47 +00:04:04,750 --> 00:04:09,150 +بتصير عملية الاحتكاج ورده فوظيفته أول إشي يمنع + +48 +00:04:09,150 --> 00:04:15,120 +الاحتكاجبيمسمح للحركة يبقى the primary function to + +49 +00:04:15,120 --> 00:04:18,080 +allow movement of the surface with minimal + +50 +00:04:18,080 --> 00:04:21,320 +friction and wear لأنه إذا صار في عندنا friction + +51 +00:04:21,320 --> 00:04:25,080 +أو صار في احتكار عملية ال wear and tear بتحصل و + +52 +00:04:25,080 --> 00:04:29,300 +بعدها بيتبعها طبعا كتير من القلم و loss of + +53 +00:04:29,300 --> 00:04:33,070 +function و ال stiffnessduring the joint motion the + +54 +00:04:33,070 --> 00:04:36,930 +cartilage is continuously exposed to gravitation + +55 +00:04:36,930 --> 00:04:40,870 +stress وكمان stress produced by muscle contraction + +56 +00:04:40,870 --> 00:04:44,550 +احنا ال weight bearing على ال joint عادة يعني احنا + +57 +00:04:44,550 --> 00:04:48,570 +و احنا واقفين بيكون في عندنا ضغط من ال weight of + +58 +00:04:48,570 --> 00:04:51,920 +the headعلى ال cervical spine و من ال cervical + +59 +00:04:51,920 --> 00:04:57,900 +spine بنزل مع ال shoulder girdle بنزل الوزن على ال + +60 +00:04:57,900 --> 00:05:01,760 +vertebra thoracic و بعدين على ال lumbar و بعدين + +61 +00:05:01,760 --> 00:05:05,300 +بنزل على ال both lower limbs فطول الوقت في + +62 +00:05:05,300 --> 00:05:10,280 +compression على ال cartilage of the joints اللي + +63 +00:05:10,280 --> 00:05:14,890 +احنا واقفين و واقفين عليهافبالتالي بيكون في عندنا + +64 +00:05:14,890 --> 00:05:21,950 +stress على ال .. المفاصل و كمان لما بيصير في عندنا + +65 +00:05:21,950 --> 00:05:25,670 +muscle contraction فال articular cartilage بيكون + +66 +00:05:25,670 --> 00:05:28,870 +برضه من خلال الحركة لما بيصير في عندنا muscle + +67 +00:05:28,870 --> 00:05:31,470 +contraction مع أن بيصير في عندنا حركة على المفصل + +68 +00:05:31,470 --> 00:05:35,730 +بيصير برضه عملية tension على هذا ال .. ال + +69 +00:05:35,730 --> 00:05:39,710 +cartilageال cartridge هو مافيش فيه blood supply زي + +70 +00:05:39,710 --> 00:05:42,470 +ما احنا حكينا في البداية ولا فيه lymphatic + +71 +00:05:42,470 --> 00:05:46,870 +channels ولا فيه neurological innervation هذا يعني + +72 +00:05:46,870 --> 00:05:52,730 +انه هو يعني ضعيف من ناحية تقضية التروية الدموية + +73 +00:05:52,730 --> 00:05:55,030 +فيه لإن ماتباخدش تروية مباشرة عن طريق blood + +74 +00:05:55,030 --> 00:05:57,850 +vesselsعشان هي كمان بيصيرش فيه عملية ال + +75 +00:05:57,850 --> 00:06:00,630 +regeneration لو صار فيه destruction و عملتيله + +76 +00:06:00,630 --> 00:06:04,950 +الاتر بتكون بتحصل لإنه هو دائما قولنا بيكون + +77 +00:06:04,950 --> 00:06:09,050 +exposed ل stress و كانت فيه gravitational أو ال + +78 +00:06:09,050 --> 00:06:14,930 +stress من ال muscle contractionsطيب ال .. ال + +79 +00:06:14,930 --> 00:06:18,630 +cartilage ال forces اللى بتعرضلها ال cartilage فى + +80 +00:06:18,630 --> 00:06:21,550 +عندنا rotatory component و فى عندنا non rotatory + +81 +00:06:21,550 --> 00:06:24,630 +component ال rotatory component اللى بتكون ناتشة + +82 +00:06:24,630 --> 00:06:27,910 +عن ال movement اللى هى تبعت ال segment أو ال + +83 +00:06:27,910 --> 00:06:32,770 +rotation تبعت المفصل فعادة ال muscle contraction + +84 +00:06:32,770 --> 00:06:36,310 +لما بيحصل بيعمل movement على افترضنا على ال elbow + +85 +00:06:36,310 --> 00:06:39,810 +joint مثلا ال biceps بده تعمل affliction لال elbow + +86 +00:06:39,810 --> 00:06:44,050 +jointفي هذه الحالة القوة الناتجة عن ال muscle + +87 +00:06:44,050 --> 00:06:47,890 +contraction اللي احنا بنسميها ال biceps بتشتغل على + +88 +00:06:47,890 --> 00:06:51,210 +.. بتتحلل لتنين من ال forces ال rotatory force + +89 +00:06:51,210 --> 00:06:54,550 +اللي هي بتعمل عملية ال movement أو ال rotation أو + +90 +00:06:54,550 --> 00:06:57,420 +ال angulation اللي بيصير في المبصرو ال non + +91 +00:06:57,420 --> 00:07:01,900 +-rotatory component اللي هي بتكون parallel على ال + +92 +00:07:01,900 --> 00:07:07,100 +axis of the segment و عادة بتكون وظيفتها ان تعمل + +93 +00:07:07,100 --> 00:07:12,240 +stabilization لالجذب لو تخيلنا انه ال .. كل مفصل + +94 +00:07:12,240 --> 00:07:16,260 +كل ما صارت فيه حركة بده يزوغ المفصل فهذا أكيد + +95 +00:07:16,260 --> 00:07:20,580 +بيكون مؤلم للغاية فعادة ال .. ال muscle + +96 +00:07:20,580 --> 00:07:26,490 +contraction بيعمل stabilizationللمفصل كمان فهذا + +97 +00:07:26,490 --> 00:07:31,430 +بيأثر على ال articular cartilage من ناحية انه ممكن + +98 +00:07:31,430 --> 00:07:35,070 +يصير في عندنا compression load او ممكن يصير في + +99 +00:07:35,070 --> 00:07:38,450 +عندنا shearing .. shearing load و tensile load + +100 +00:07:38,450 --> 00:07:44,450 +طبعا ال .. ال articular ال .. ال .. بيصير ال force + +101 +00:07:44,450 --> 00:07:47,210 +عن طريق ال compression على ال articular surfaces + +102 +00:07:47,210 --> 00:07:50,650 +against each other لإن هو بده يثبتهم مع بعض عشان + +103 +00:07:50,650 --> 00:07:56,370 +ما ي ..ما .. مايزغوش هاد ال force عادة بتكون مهمة + +104 +00:07:56,370 --> 00:08:01,770 +زيها زي ال rotatory force لإنها بتبدأ عادة بتكون + +105 +00:08:01,770 --> 00:08:05,910 +موجودة في بداية الحركة عساس إنها تثبت المفصل من + +106 +00:08:05,910 --> 00:08:12,330 +عملية ال .. الإزاحة أو الزواغانthe .. so the joint + +107 +00:08:12,330 --> 00:08:16,850 +cartilage has to sustain a compression stress + +108 +00:08:16,850 --> 00:08:20,530 +considerable degree which cause wear and tear of + +109 +00:08:20,530 --> 00:08:23,670 +the articular cartilage and the joint surfaces + +110 +00:08:23,670 --> 00:08:27,020 +طبعا عملية ال wear and tear بتصيرلأن عملية + +111 +00:08:27,020 --> 00:08:29,900 +الاحتكاك اللي هي وظيفة ال cartilage نفسه أساسا + +112 +00:08:29,900 --> 00:08:34,000 +إنها تمنعها بس طبعا لإن هو بيتعرض بستمرار بستمرار + +113 +00:08:34,000 --> 00:08:38,500 +لهذه ال compression فممكن يتعرضوا لل wear and tear + +114 +00:08:38,500 --> 00:08:41,760 +أو ال damage طيب وظيفة تانية لل articular + +115 +00:08:41,760 --> 00:08:45,580 +cartilageإنها بتوزع ال load احنا قلنا بتسوّد + +116 +00:08:45,580 --> 00:08:49,080 +المساحة تبع المفصل ف بيقل ال pressure قلنا هو ال + +117 +00:08:49,080 --> 00:08:52,340 +pressure عبارة عن ال force على ال area كل ما كبرت + +118 +00:08:52,340 --> 00:08:55,660 +ال area لإن هي ال area هي في المقام فكل ما كبر + +119 +00:08:55,660 --> 00:09:00,180 +المقام كل ما بقل ال stress اللي موجود على السطح + +120 +00:09:00,180 --> 00:09:04,320 +يبقى ال contact stress decrease ليش؟ لأن ال stress + +121 +00:09:04,320 --> 00:09:09,260 +بساوي ال force على ال area طبعا it changesthe + +122 +00:09:09,260 --> 00:09:13,280 +contact area during joint motion minimize the + +123 +00:09:13,280 --> 00:09:16,640 +stress which may cause wear and tear upon the + +124 +00:09:16,640 --> 00:09:21,500 +cartilage so that stress is not concentrated at + +125 +00:09:21,500 --> 00:09:27,420 +one small areaتوزيع المساحة .. توزيع القوة على + +126 +00:09:27,420 --> 00:09:31,800 +اللي المساحة بيقلل من ال stress اللي حاصل و بيقلل + +127 +00:09:31,800 --> 00:09:35,900 +من عملية ال wear and tear على المفصل طب و من إيش + +128 +00:09:35,900 --> 00:09:43,350 +بتكون هذا ال cartilage؟ هو ال compositionالو طبعا + +129 +00:09:43,350 --> 00:09:47,570 +فيه collagen و فيه proteoglycan و فيه water و + +130 +00:09:47,570 --> 00:09:52,430 +inorganic salt زي أي شي في جسم الإنسان المكون .. + +131 +00:09:52,430 --> 00:09:56,550 +الأكتر مكون الو بيكون water و كمان ال collagen و + +132 +00:09:56,550 --> 00:10:00,700 +ال proteoglycanطبعا ال stress بتوزع على ال .. عن + +133 +00:10:00,700 --> 00:10:04,560 +طريق .. على ال cartridge و بعمل زي شكل ال wave + +134 +00:10:04,560 --> 00:10:08,620 +يعني زي .. زي الموج كده بت .. بتوزع يعني بنزل على + +135 +00:10:08,620 --> 00:10:13,420 +المنطقة اللي بيكون فيها ال .. الضغط و بعدين بيبدأ + +136 +00:10:13,420 --> 00:10:21,100 +ينتشر على شكل wavesطبعا ال .. that lead to the + +137 +00:10:21,100 --> 00:10:24,760 +development of shear and tension stresses which + +138 +00:10:24,760 --> 00:10:29,900 +must be taken up by tension resisting network اللي + +139 +00:10:29,900 --> 00:10:35,220 +هو ال collagen fibers و تركيبته و هنتعرف عندنا كيف + +140 +00:10:35,220 --> 00:10:39,380 +ان هو بيتكون من تلت طبقات، التلت طبقات هذه تركيبة + +141 +00:10:39,380 --> 00:10:45,330 +ال collagen فيها بتختلفعشان في كل نوع منها بتقاوم + +142 +00:10:45,330 --> 00:10:49,210 +نوع من ال forces اللي applied يبقى ال .. ال + +143 +00:10:49,210 --> 00:10:53,590 +network هذا بتكوّل من إيش؟ من collagen fibrils + +144 +00:10:53,590 --> 00:11:00,110 +which ranges from 15 to 22 percent of the network + +145 +00:11:00,110 --> 00:11:05,670 +تبعال .. ال cartilage و في حاجة اسمة proteoglycan + +146 +00:11:05,670 --> 00:11:13,790 +اللي هو content حوالي 4 ل 7% من ال wet .. wet ال + +147 +00:11:13,790 --> 00:11:18,370 +.. من المكون الرطب و كمان في عندنا ال water و ال + +148 +00:11:18,370 --> 00:11:24,050 +inorganic salts اللي بتشكل حوالي من 60 ل 5 او 80% + +149 +00:11:24,050 --> 00:11:29,110 +و طبعا في matrix و protein و glycoproteins و + +150 +00:11:29,110 --> 00:11:33,930 +lipids و ما إلا ذلكطيب الcollision كيف تركيبته؟ + +151 +00:11:33,930 --> 00:11:37,230 +إيش هو؟ الcollision has a high level of structural + +152 +00:11:37,230 --> 00:11:41,730 +organization لإن هو بتكون من تلت طبقات result in + +153 +00:11:41,730 --> 00:11:45,930 +optimum mechanical properties اللي بتعطي أصل أصلا + +154 +00:11:45,930 --> 00:11:49,590 +ال mechanical properties تبع ال cartilage نفسه + +155 +00:11:49,590 --> 00:11:53,230 +اللي هي ال function of collision بيعطينا tensile + +156 +00:11:53,230 --> 00:11:58,650 +stiffnessand strength properties as ال fibers are + +157 +00:11:58,650 --> 00:12:03,490 +in tension even لو ماكنش في عندها stresses applied + +158 +00:12:03,490 --> 00:12:09,170 +وكمان في عندنا بي .. بيعطي ال cartilage stress + +159 +00:12:09,170 --> 00:12:12,630 +يعني resistant لل stress و ال strains على ال + +160 +00:12:12,630 --> 00:12:16,630 +articular cartilage يعني بيقوم ال stress و ال + +161 +00:12:16,630 --> 00:12:19,520 +strain اللي بيكون على ال cartilageبنسبة + +162 +00:12:19,520 --> 00:12:23,560 +للـarrangement للـcollision هنلاقي أنه هو في عبارة + +163 +00:12:23,560 --> 00:12:27,300 +عن تلاتة zones و .. و zones هذه separated تركيبة + +164 +00:12:27,300 --> 00:12:31,480 +الـcollision فيها بتختلف من ال superficial ل ال + +165 +00:12:31,480 --> 00:12:34,860 +deep طبعا كل واحدة إلها properties خاصة فيها بتقوم + +166 +00:12:34,860 --> 00:12:39,310 +stresses معينةالـ superficial layer بتقاوم دائما + +167 +00:12:39,310 --> 00:12:45,070 +الـ tensile stretch لأنها هي بتكون معرضة أكتر إشي + +168 +00:12:45,070 --> 00:12:49,830 +لـ tensile forces بتشكل عشرة لعشرين في المية من ال + +169 +00:12:49,830 --> 00:12:53,630 +total thickness وكمان هي عبارة عن densely packed + +170 +00:12:53,630 --> 00:12:58,770 +fine fibrils elliptical شكلها بيضاوي and flattened + +171 +00:12:58,770 --> 00:13:05,270 +زي ما إحنا شايفينها بهذا الشكلهنا هي عبارة عن + +172 +00:13:05,270 --> 00:13:11,030 +elliptical بيضاوية و .. و مسطحة و بت .. بتكون + +173 +00:13:11,030 --> 00:13:15,270 +مرتبة parallel to the articular surface يعني احنا + +174 +00:13:15,270 --> 00:13:18,570 +دائما كنا بنمثلها في التعليم الوجاهي بنمسك خمس + +175 +00:13:18,570 --> 00:13:22,170 +أقلام و بنمسكهم كده و بنصفطهم و بنمسكهم بالعرض و + +176 +00:13:22,170 --> 00:13:26,310 +بنحاول اننا نجدهمأو نكسرهم طبعا صعب كتير ان نقدر + +177 +00:13:26,310 --> 00:13:31,470 +نتعجهم او .. او .. او نشدهم فهذا لأنه في مقاومة + +178 +00:13:31,470 --> 00:13:36,810 +كبيرة لهم و هم مرتبين in parallel way طبعا ال + +179 +00:13:36,810 --> 00:13:41,050 +arrangement هذا sort of protecting not allowing + +180 +00:13:41,050 --> 00:13:45,470 +the fiber to move apart without losing tensile + +181 +00:13:45,470 --> 00:13:48,230 +strength طب نشوف ال zone التانية ال middle zone + +182 +00:13:48,230 --> 00:13:53,170 +بتشكل 40لـ 60% من الـ total thickness هذه الـ zone + +183 +00:13:53,170 --> 00:14:01,230 +بتكون مرتبة randomly distributed in oblique way زي + +184 +00:14:01,230 --> 00:14:05,790 +ما احنا شفناها في الحلقات هنشوفها في هذا الشكل + +185 +00:14:05,790 --> 00:14:09,690 +شايفين هنا ال surface كيف هنا parallel و ال middle + +186 +00:14:09,690 --> 00:14:14,170 +zone بتكون randomly و هنروح لل deep zone اللي هي + +187 +00:14:14,170 --> 00:14:21,880 +بتكون شكلة وقفة عموديا طيب ال deep zoneهي بتشكل 30 + +188 +00:14:21,880 --> 00:14:24,020 +% من الـ total thickness و هذه الـ zone + +189 +00:14:24,020 --> 00:14:29,960 +arrangement بتكون perpendicular to the cartilage و + +190 +00:14:29,960 --> 00:14:36,360 +بتكون قريبة من ال TED mark اللي هي الحد الفاصل ما + +191 +00:14:36,360 --> 00:14:40,040 +بين ال bone و ال inter surface ال inter surface of + +192 +00:14:40,040 --> 00:14:44,480 +the bone و ال cartilageهذه تكون الـ Parallel + +193 +00:14:44,480 --> 00:14:52,560 +Orientation للـ Fibers الموجودة في السطح تختلف + +194 +00:14:52,560 --> 00:14:56,660 +خواصها عن الـ Perpendicular Orientation + +195 +00:14:59,020 --> 00:15:04,040 +البراليل فوق في السطح بتعطينا stiffness أكتر لل .. + +196 +00:15:04,040 --> 00:15:08,140 +لل tensile force و ال perpendicular بتعطينا + +197 +00:15:08,140 --> 00:15:12,540 +stiffness أكتر ل ال compression force طبعا tensile + +198 +00:15:12,540 --> 00:15:16,560 +stiffness of the superficial layer بتقريبا بشكل + +199 +00:15:16,560 --> 00:15:21,320 +عشرين مرة أكتر من ال deep zone + +200 +00:15:25,810 --> 00:15:32,010 +طبعا هذا الشكل اللي بيوضح أن الترتيبة تبعت ال + +201 +00:15:32,010 --> 00:15:37,190 +different zones of the cartilage superficial وهي + +202 +00:15:37,190 --> 00:15:41,510 +بتشكل العشرة لعشرين في المية وهي برا لل fibers هذي + +203 +00:15:41,510 --> 00:15:46,150 +middle zone randomly organized أما ال deep zone + +204 +00:15:46,150 --> 00:15:47,250 +فهي + +205 +00:15:52,380 --> 00:15:57,940 +perpendicular فهي يعني بتقاوم أكتر ال .. يعني نفس + +206 +00:15:57,940 --> 00:16:00,740 +الإقلام هدول اللي كنا حاكينا عنهم بالأول لو + +207 +00:16:00,740 --> 00:16:04,740 +مسيكنهم بشكل .. بشكل عموده سهل أننا اننا لو .. لو + +208 +00:16:04,740 --> 00:16:08,220 +شدناهم يتفرقوا عن .. عن بعضهم + +209 +00:16:14,970 --> 00:16:18,570 +طيب there is decrease in tensile stiffness or + +210 +00:16:18,570 --> 00:16:22,870 +strength كل ما راحت روحنا deeper في ال surface كل + +211 +00:16:22,870 --> 00:16:25,290 +ما زادت ال distance from the surface of the + +212 +00:16:25,290 --> 00:16:29,170 +articular cartilage ال superficial layer is + +213 +00:16:29,170 --> 00:16:34,350 +protective for the articular cartilage وظيفتها + +214 +00:16:34,350 --> 00:16:38,010 +انها ت resist the tensile strain produced by + +215 +00:16:38,010 --> 00:16:41,490 +compression and friction at the joint والدي بصتون + +216 +00:16:41,750 --> 00:16:46,130 +هي بتعطيني resistant أكتر لـ compression load due + +217 +00:16:46,130 --> 00:16:49,910 +to its perpendicular orientation طيب الـ + +218 +00:16:49,910 --> 00:16:55,410 +proteoglycan هو المكوّن التاني من مكونات الـ + +219 +00:16:55,410 --> 00:16:59,050 +cartilage articular cartilage ال function تبعته هي + +220 +00:16:59,050 --> 00:17:04,770 +عبارة عن عملية بتعمل عملية الترابط ما بين ال .. ال + +221 +00:17:04,770 --> 00:17:09,970 +.. زي هي تقولوا المادة اللاصقة تبعت ال .. ال + +222 +00:17:09,970 --> 00:17:15,710 +collagen fibersهي large protein polysaccharide + +223 +00:17:15,710 --> 00:17:21,190 +molecules composed of protein core to which one or + +224 +00:17:21,190 --> 00:17:24,810 +more glycosaminoglycans + +225 +00:17:26,840 --> 00:17:30,840 +اللي هي اختصارها الـ GAGs are attached طبعا الـ + +226 +00:17:30,840 --> 00:17:35,880 +proteoglytin are strongly hydrophilic substance + +227 +00:17:35,880 --> 00:17:41,680 +طبعا occupying large solvent domains in the + +228 +00:17:41,680 --> 00:17:45,760 +aquatic solution طبعا هو وظيفته انه يعمل الترابط + +229 +00:17:45,920 --> 00:17:49,540 +اللي هو عبارة عن الـ bending substance to the + +230 +00:17:49,540 --> 00:17:52,660 +collagen molecule at a certain level within the + +231 +00:17:52,660 --> 00:17:59,380 +cartilage وكأن هو الغرة اللي بيمسك ال collagen + +232 +00:17:59,380 --> 00:18:03,960 +fibers مع بعضها لما بيصير في عندنا when stress is + +233 +00:18:03,960 --> 00:18:06,880 +applied to the cartilage surface في عندنا + +234 +00:18:06,880 --> 00:18:11,500 +interestantious deformation بيصير فيه تغيير على + +235 +00:18:11,500 --> 00:18:17,750 +شكلال .. ال cartilage بيكون .. بسمح في ال .. + +236 +00:18:17,750 --> 00:18:22,090 +التغيير هذا في الشراب ال proteoglycan لإن هزيل + +237 +00:18:22,090 --> 00:18:29,360 +كأنه مادة لاصقة و لذيجة كمان في نفس ال ..الوقت طيب + +238 +00:18:29,360 --> 00:18:34,920 +احنا هيك اليوم بنكون وصلنا لنهاية محادرتنا في ال + +239 +00:18:34,920 --> 00:18:41,480 +articular cartilage و هنتعرف على الخواص تبعته أكتر + +240 +00:18:41,480 --> 00:18:45,300 +في المحادرة القادمة ان شاء الله + diff --git a/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/K0Itx2h-rz8_raw.json b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/K0Itx2h-rz8_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..dedb886b683c1c20b262b397962a5b10d42d9d45 --- /dev/null +++ b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/K0Itx2h-rz8_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 1814, "start": 0.0, "end": 18.14, "text": "بسم الله الرحمن الرحيم الصلاة والسلام علي سيدنا محمد وعلي ألي وصحابي أجمعين هنتكلم اليوم المحاضرة التالتة عن ال gate هنتكلم عن ال abnormal gate patterns و هنشوف ليش بيصير في عندنا deviation في ال gate و ليش بيصير في عندنا limping", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 31767, 15040, 3660, 16070, 3794, 37440, 25894, 8608, 25708, 8315, 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the knee backward into extension طبعا in addition the person may physically push on the anterior thigh during stance with holding the knee in extension يعني هو بيركزها يعني هو بخبط ايده كده على فوق النيه عشان النيه تظل هائب extension بفرد رجله يعني نشوف الفيديو مع بعض", "tokens": [1211, 2407, 12174, 3215, 10943, 294, 1868, 295, 264, 9434, 341, 486, 3464, 264, 9434, 23897, 666, 10320, 23032, 3555, 3615, 995, 294, 4500, 264, 954, 815, 9762, 2944, 322, 264, 22272, 27871, 1830, 21033, 365, 5061, 264, 9434, 294, 10320, 37495, 22653, 31439, 4724, 13546, 4117, 11622, 11296, 37495, 22653, 31439, 4724, 9778, 3555, 9566, 1975, 25708, 3224, 9122, 3215, 3224, 15844, 6156, 30543, 2423, 22653, 3224, 6225, 8592, 7649, 2423, 22653, 3224, 6055, 19913, 1211, 8032, 16373, 3555, 10320, 4724, 5172, 2288, 3215, 12602, 7435, 43761, 37495, 22653, 8717, 8592, 38688, 27188, 1829, 16254, 2407, 20449, 45030, 11242], "avg_logprob": -0.1676980221625602, "compression_ratio": 1.59375, "no_speech_prob": 0.0, "words": 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At the time of heel strike, the knee is normally in full extension. 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0.92529296875}, {"start": 830.63, "end": 830.79, "word": " the", "probability": 0.9189453125}, {"start": 830.79, "end": 831.13, "word": " patient", "probability": 0.890625}, {"start": 831.13, "end": 831.35, "word": " may", "probability": 0.9560546875}, {"start": 831.35, "end": 831.67, "word": " attempt", "probability": 0.95458984375}, {"start": 831.67, "end": 831.91, "word": " to", "probability": 0.9697265625}, {"start": 831.91, "end": 832.17, "word": " push", "probability": 0.85888671875}, {"start": 832.17, "end": 832.45, "word": " on", "probability": 0.9501953125}, {"start": 832.45, "end": 832.59, "word": " the", "probability": 0.91943359375}, {"start": 832.59, "end": 832.99, "word": " thigh", "probability": 0.94091796875}, {"start": 832.99, "end": 833.41, "word": " in", "probability": 0.85791015625}, {"start": 833.41, "end": 833.69, "word": " order", "probability": 0.92138671875}, {"start": 833.69, "end": 833.91, "word": " to", "probability": 0.97265625}, {"start": 833.91, "end": 834.43, "word": " extend", "probability": 0.91259765625}, {"start": 834.43, "end": 834.81, "word": " and", "probability": 0.94970703125}, {"start": 834.81, "end": 835.13, "word": " lock", "probability": 0.93603515625}, {"start": 835.13, "end": 835.35, "word": " the", "probability": 0.92431640625}, {"start": 835.35, "end": 835.61, "word": " knee", "probability": 0.8662109375}], "temperature": 1.0}, {"id": 36, "seek": 87112, "start": 852.36, "end": 871.12, "text": "الهمسترنغز الهمسترنغز هنا زي ما احنا شايفينه يكون فيه weakness فيهمسترنغز بس في حاجة اسمها generic of atom بتصير الرجل وكانها في hyper extension if hamstring are weak two things may happen during sun phase the knee will go into excessive hyper extension", "tokens": [6027, 16095, 14851, 2288, 1863, 17082, 11622, 2423, 16095, 14851, 2288, 1863, 17082, 11622, 34105, 30767, 1829, 19446, 1975, 5016, 8315, 13412, 995, 33911, 9957, 3224, 7251, 30544, 8978, 3224, 12772, 8978, 16095, 14851, 2288, 1863, 17082, 11622, 4724, 3794, 8978, 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859.82, "word": " الرجل", "probability": 0.7626139322916666}, {"start": 859.82, "end": 860.38, "word": " وكانها", "probability": 0.7240397135416666}, {"start": 860.38, "end": 860.52, "word": " في", "probability": 0.9580078125}, {"start": 860.52, "end": 861.04, "word": " hyper", "probability": 0.76416015625}, {"start": 861.04, "end": 862.6, "word": " extension", "probability": 0.8134765625}, {"start": 862.6, "end": 862.9, "word": " if", "probability": 0.8359375}, {"start": 862.9, "end": 863.42, "word": " hamstring", "probability": 0.556884765625}, {"start": 863.42, "end": 863.78, "word": " are", "probability": 0.93017578125}, {"start": 863.78, "end": 864.14, "word": " weak", "probability": 0.96826171875}, {"start": 864.14, "end": 864.38, "word": " two", "probability": 0.72509765625}, {"start": 864.38, "end": 864.74, "word": " things", "probability": 0.89208984375}, {"start": 864.74, "end": 864.98, "word": " may", "probability": 0.9267578125}, {"start": 864.98, "end": 865.5, "word": " 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894.03, "text": "Sometimes referred to as Genorequivate again لأن هنا إيش اللي بيصير during the deceleration تبع ال swing phase إيش اللي بيصير إن الهمسترنج المفروض تعمل slow down لل swing بتقلل من ال snapping من أن الرجل تبقى هيك ترط يعني تخبط", "tokens": [50, 45890, 10839, 281, 382, 3632, 418, 358, 592, 473, 797, 5296, 33456, 34105, 11933, 1829, 8592, 13672, 1829, 4724, 1829, 9381, 13546, 1830, 264, 979, 16096, 6055, 3555, 3615, 2423, 11173, 5574, 11933, 1829, 8592, 13672, 1829, 4724, 1829, 9381, 13546, 36145, 2423, 16095, 14851, 2288, 1863, 7435, 9673, 5172, 32887, 11242, 6055, 25957, 1211, 2964, 760, 24976, 11173, 39894, 4587, 1211, 1211, 9154, 2423, 42727, 9154, 14739, 34892, 7435, 1211, 6055, 3555, 4587, 7578, 39896, 4117, 6055, 2288, 9566, 37495, 22653, 6055, 9778, 3555, 9566], "avg_logprob": -0.34801137108694424, "compression_ratio": 1.4930232558139536, "no_speech_prob": 0.0, "words": [{"start": 871.91, "end": 872.63, "word": "Sometimes", "probability": 0.6575927734375}, 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هناخد اليوم ال + +3 +00:00:16,000 --> 00:00:22,320 +muscle variables و .. و نشوف إيش تأثير ال .. ال + +4 +00:00:22,320 --> 00:00:25,580 +different variables of the muscle على ال strength + +5 +00:00:25,580 --> 00:00:31,000 +في عندنا ال muscle length رقم واحد، في عندنا two + +6 +00:00:31,000 --> 00:00:34,600 +main types of muscle length، في عندنا ال resting + +7 +00:00:34,600 --> 00:00:39,100 +length، و عندنا ال equilibrium length، ال resting + +8 +00:00:39,100 --> 00:00:47,010 +length هو عبارة عن ال ..العدلة طول العضلة ال + +9 +00:00:47,010 --> 00:00:51,270 +length of an uncontracted and unstretched muscle + +10 +00:00:51,270 --> 00:00:56,830 +طول العضلة الطبيعي without any contraction ولا + +11 +00:00:56,830 --> 00:01:01,470 +stretching of the muscle، أما ال equilibrium length + +12 +00:01:01,470 --> 00:01:05,320 +بدنا نتخيل أنه بناخد isolated muscle، هو ال length + +13 +00:01:05,320 --> 00:01:09,340 +of an isolated muscle and contracted، لو عزلنا + +14 +00:01:09,340 --> 00:01:12,620 +العضلة هذه، شيلناها من أطرافها الاثنين، ال origin and + +15 +00:01:12,620 --> 00:01:19,290 +ال insertion، بنلاقي العضلة بتأثر، بتقصر تقريبا 10% + +16 +00:01:19,290 --> 00:01:26,570 +من طولها، لو كان طول العضلة 30 cm فهي بتقصر 3 cm + +17 +00:01:26,570 --> 00:01:29,810 +تقريبا، لو شلناها من المكان لأن هي بتكون بين ال + +18 +00:01:29,810 --> 00:01:34,830 +origin و ال insertion، مجدودة حتى لو كانت في وضع + +19 +00:01:34,830 --> 00:01:38,630 +الراحة، يبقى ال resting length هو ال intact length + +20 +00:01:38,630 --> 00:01:44,790 +العضلة سواء كانت of the non-contracted and non + +21 +00:01:44,790 --> 00:01:48,830 +stretched muscle، أما ال equilibrium فهي ال isolated + +22 +00:01:48,830 --> 00:01:53,090 +muscle أو uncontracted muscle، لو عزلنا العضلة هذه + +23 +00:01:53,090 --> 00:01:59,130 +فهي حجمها بيقصر بيصغر أو طولها بيقصر حوالي عشرة في + +24 +00:01:59,130 --> 00:02:04,990 +المية، طيب في عندنا ال .. ال variable التاني اللي + +25 +00:02:04,990 --> 00:02:10,410 +هو ال force of tension، يعني كلمة tension بنفضلها + +26 +00:02:10,410 --> 00:02:14,850 +أكثر من كلمة contraction، ليش؟ لأن contraction كانت + +27 +00:02:14,850 --> 00:02:19,770 +كلمة كانت معناها تقارب يعني هي a prefix بيعني أن + +28 +00:02:19,770 --> 00:02:24,990 +أشياء تقاربت من بعضها أو توصلت مع بعضها، أما ال + +29 +00:02:24,990 --> 00:02:30,150 +tension فهي whether كان isometric أو concentric أو + +30 +00:02:30,150 --> 00:02:34,450 +eccentric contraction، فكلمة tension بتعبر بتكون + +31 +00:02:34,450 --> 00:02:40,690 +معبرة أكثر، tension can be applied to any type of + +32 +00:02:40,690 --> 00:02:44,350 +tension developed regardless of whether ال muscle + +33 +00:02:44,350 --> 00:02:47,970 +shortened or lengthened or remained the same + +34 +00:02:47,970 --> 00:02:52,050 +length، سواء كان concentric contraction, eccentric + +35 +00:02:52,050 --> 00:02:58,930 +contraction or isometric contraction، طبعا ال force + +36 +00:02:58,930 --> 00:03:04,350 +exerted by muscle is not only dependent upon ال + +37 +00:03:04,350 --> 00:03:06,910 +active process، طبعا ال active process اللي هو + +38 +00:03:06,910 --> 00:03:14,080 +موجود اللي بيظهر مع ال contractile elements، أما في + +39 +00:03:14,080 --> 00:03:18,840 +عندنا passive tension بيصير على ال non-contractile + +40 +00:03:18,840 --> 00:03:23,360 +مع ال non-contractile element، طبعا هنا ال muscle + +41 +00:03:23,360 --> 00:03:28,520 +فيها نوعين من ال connective أو some connective + +42 +00:03:28,520 --> 00:03:33,250 +tissue، ال non-contractile element اللي هي زي ال + +43 +00:03:33,250 --> 00:03:36,270 +elastic band اللي موجودة إذا بتذكروا لما كنا + +44 +00:03:36,270 --> 00:03:40,950 +تكلمنا عن المكون المرة اللي فاتت وقلنا في عندنا ال + +45 +00:03:40,950 --> 00:03:44,930 +cross bridge اللي هو الأكتين والميوسين، وفي عندنا + +46 +00:03:44,930 --> 00:03:50,710 +ال series وكانت parallel or series elastic + +47 +00:03:50,710 --> 00:03:55,130 +components، هدولة اللي هما non-contractile elements + +48 +00:03:55,490 --> 00:04:00,550 +يبقى they behave as elastic band، exert passive + +49 +00:04:00,550 --> 00:04:04,170 +force which combines with the active contribution + +50 +00:04:04,170 --> 00:04:08,710 +due to cross bridging اللي بيصير في الميوسين and أكتين + +51 +00:04:08,710 --> 00:04:12,170 +of the contractile elements in the muscle to + +52 +00:04:12,170 --> 00:04:15,900 +produce the total force exerted by the muscle، طبعا + +53 +00:04:15,900 --> 00:04:19,320 +هي القوة اللي بتعملها العضلة هي عبارة عن force + +54 +00:04:19,320 --> 00:04:24,240 +بحثة القياس، سبعتها لنيوتن زي ما احنا بنعرف من + +55 +00:04:24,240 --> 00:04:29,420 +الفصل اللي فات، طب ال tension produced by the muscle + +56 +00:04:29,420 --> 00:04:32,300 +contraction depends mechanically on the following + +57 +00:04:32,300 --> 00:04:37,460 +factor، ال muscle length، واحد منهم طول العضلة، يبقى + +58 +00:04:37,460 --> 00:04:42,060 +العضلة هذه لما بتيجي بتعمل contraction حسب الطول + +59 +00:04:42,060 --> 00:04:46,480 +اللي بتكون فيه ساعة ما بيبدأ ال contraction، فبكون + +60 +00:04:46,480 --> 00:04:50,820 +قد إيش، في حاجة اسمها optimum length للعضلة، العضلة لما + +61 +00:04:50,820 --> 00:04:54,240 +تكون، إذا بتذكروا زمان أول ما بدأنا في مادة ال + +62 +00:04:54,240 --> 00:04:58,020 +introduction، قولنا العضلة بتشتغل أفضل شغلها في ال + +63 +00:04:58,020 --> 00:05:02,350 +intermediate range تبعها، معنى أنه لا بتشتغل منيح + +64 +00:05:02,350 --> 00:05:06,290 +إذا كانت في length position، و لا بتشتغل منيح + +65 +00:05:06,290 --> 00:05:10,890 +العضلة إذا كانت في short position، أفضل وضع بتشتغل + +66 +00:05:10,890 --> 00:05:15,450 +فيه العضلة و بيصير فيه development لإن ال tension + +67 +00:05:15,450 --> 00:05:21,430 +بيكون في ال optimum length بتاع العضلة، يبقى ال + +68 +00:05:21,430 --> 00:05:25,590 +relation between length and tension بdescribe هنا + +69 +00:05:25,590 --> 00:05:31,000 +على هذا ال curve، و زي ما احنا شايفين ال curve هنا + +70 +00:05:31,000 --> 00:05:36,080 +كاف، بيبدأ هنا ال length، كل ما قصرت العضلة بيبدأ ال + +71 +00:05:36,080 --> 00:05:40,880 +tension يصير في development، وبعدين بيستقر، وبعدين + +72 +00:05:40,880 --> 00:05:46,250 +بيعود بينزل، تمام؟ يبقى الـ active tension developed + +73 +00:05:46,250 --> 00:05:49,250 +by ال contractile elements of the muscle، وهذا + +74 +00:05:49,250 --> 00:05:53,170 +معروف أن الأكتين والميسين بيصير فيهم cross + +75 +00:05:53,170 --> 00:05:57,650 +bridging و بيصير في عملية ال contraction اللي هو + +76 +00:05:57,650 --> 00:06:02,650 +عبارة عن تداخل خيوط الأكتين والميسين أو تبعدها في + +77 +00:06:02,650 --> 00:06:06,760 +حالة ال eccentric contraction كمان، طب وقتش بصير + +78 +00:06:06,760 --> 00:06:10,680 +عندنا passive tension، لما بتبدأ ال muscle develop + +79 +00:06:10,680 --> 00:06:14,380 +when the muscle is stretched beyond its resting، + +80 +00:06:14,380 --> 00:06:18,920 +ببدأ انشدها أكثر من ال resting position و ال non + +81 +00:06:18,920 --> 00:06:23,800 +contractile muscle بلي بيبدأ يصير فيه stretch، طيب + +82 +00:06:23,970 --> 00:06:27,350 +When the muscle contracts both the active and the + +83 +00:06:27,350 --> 00:06:30,610 +passive tension هو بيعطينا ال total tension + +84 +00:06:30,610 --> 00:06:34,930 +exerted اللي احنا بنشوفه لما بنعمل ال contraction + +85 +00:06:34,930 --> 00:06:41,170 +للعضلة سواء كان في concentric أو eccentric work + +86 +00:06:41,640 --> 00:06:47,520 +الخطوة تشير إلى أنه عندما يتجسس المصدر بيوند موقعه + +87 +00:06:47,520 --> 00:06:53,280 +التجسسية، الباسيف التنشن بيزيد و ال active tension + +88 +00:06:53,280 --> 00:06:58,280 +بيقل لأنه بيصير ال load أكثر على ال non + +89 +00:06:58,280 --> 00:07:03,500 +contractile element فبزيد عليها ال tension بتزيد + +90 +00:07:03,500 --> 00:07:08,000 +ال tension، أما ال active tension فهو بيقل، ال + +91 +00:07:08,000 --> 00:07:11,320 +muscle can develop maximal tension at optimum + +92 +00:07:11,320 --> 00:07:15,380 +length because the thin and thick filaments of the + +93 +00:07:15,380 --> 00:07:19,640 +muscles are overlapped، بيصير فيه تداخل على الـ + +94 +00:07:19,640 --> 00:07:23,200 +thin و ال thick filaments، الميوسين و الأكتين + +95 +00:07:23,200 --> 00:07:29,010 +بيعطيني ال maximum number of cross bridging، يمكن أن + +96 +00:07:29,010 --> 00:07:35,490 +يتم تفعيلها بشكل عميق أو أقصر أكثر من أقصر أقصر + +97 +00:07:35,490 --> 00:07:37,170 +أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر + +98 +00:07:37,170 --> 00:07:37,470 +أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر + +99 +00:07:37,470 --> 00:07:40,470 +أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر أقصر + +100 +00:07:40,470 --> 00:07:47,280 +أقصر أقصر أقصر أقصر، less overlapping لـ myosin + +101 +00:07:47,280 --> 00:07:50,520 +والأكتين اللي هم الـ thin and thick filaments of + +102 +00:07:50,520 --> 00:07:54,580 +the muscle، وفي عندنا less number من ال cross + +103 +00:07:54,580 --> 00:08:02,320 +bridging، عدد اللي هو ال myosin والأكتين بيقل طبعا + +104 +00:08:04,310 --> 00:08:08,190 +اللي هدول هي ال contractile elements اللي موجودة في + +105 +00:08:08,190 --> 00:08:15,230 +العضلة نفسها، طبعا في عندنا هدول الظاهرة مابتبينش في + +106 +00:08:15,230 --> 00:08:19,730 +ال mono-articular joint، يعني most one joint muscle + +107 +00:08:19,730 --> 00:08:23,110 +أو mono-articular muscle are not stretched enough + +108 +00:08:23,110 --> 00:08:27,450 +for ال passive tension حتى يظهر أو يبداله role هدول + +109 +00:08:27,450 --> 00:08:31,070 +بتصير موجودة أكثر في ال two joint muscle أو اللي + +110 +00:08:31,070 --> 00:08:35,400 +بنسميه bi-articular muscles، ليش؟ لأن هي بتعدي على + +111 +00:08:35,400 --> 00:08:41,840 +two joints و بتكون عادة هي أطول، زي مثلا لو احنا + +112 +00:08:41,840 --> 00:08:46,020 +كلنا رفعنا إيدنا ال wrist لما بنعمل .. بتروح إيدنا + +113 +00:08:46,020 --> 00:08:50,380 +بال extension، wrist extension فبنلاقي ال fingers + +114 +00:08:50,380 --> 00:08:56,120 +تلقائيا بتلاقيها بتتنى، لو روحنا بإيدنا ب wrist + +115 +00:08:56,120 --> 00:09:00,540 +flexion بنلاقي ال fingers بيصير فيها extension و + +116 +00:09:00,540 --> 00:09:04,060 +هذا بيوضح لنا عملية الـ passive و الـ active + +117 +00:09:04,060 --> 00:09:10,680 +tension، طبعا هنا clinically the influence of pre + +118 +00:09:10,680 --> 00:09:14,400 +contraction stretch can be achieved، وهذه ممكن + +119 +00:09:14,400 --> 00:09:18,840 +جزئية عشان تحسوا فيها بدها شوية عملية احنا عادة + +120 +00:09:18,840 --> 00:09:22,660 +بنعمل، إذا أنتو درستوا ال BNF، إذا بتذكروا كنا + +121 +00:09:22,660 --> 00:09:25,440 +بنقول أول ما بنبدأ ال contraction بنعمل sudden + +122 +00:09:25,440 --> 00:09:29,680 +stretch على ال muscle عشان نأخر ال contraction + +123 +00:09:29,680 --> 00:09:35,970 +وطول ما احنا في course of movement بنعمل stretching + +124 +00:09:35,970 --> 00:09:41,250 +للعضلة فبنحفظ ال energy اللي موجودة في العضلة أنها + +125 +00:09:41,250 --> 00:09:45,070 +تظهر، يبقى clinically the influence of contraction + +126 +00:09:45,070 --> 00:09:49,370 +stretch can be achieved by applying stretch before + +127 +00:09:49,370 --> 00:09:53,230 +muscle تعمل مع الـ stretch reflex احنا contraction + +128 +00:09:53,230 --> 00:09:56,390 +or by lengthening the muscle during the course of + +129 +00:09:56,390 --> 00:10:01,930 +contraction. In this case, greater amount of tension + +130 +00:10:01,930 --> 00:10:05,670 +can be generated from the non-contractile elements + +131 +00:10:05,670 --> 00:10:12,270 +of the muscle. طبعا الـ muscle perform more work + +132 +00:10:12,270 --> 00:10:15,710 +when shortened immediately after being stretched + +133 +00:10:15,710 --> 00:10:18,410 +يعني احنا بنعمل concentric contraction بنبقى شدينا + +134 +00:10:18,410 --> 00:10:22,990 +العضلة و بعدين عملنا الـ contraction فبيكون جهد على + +135 +00:10:22,990 --> 00:10:28,380 +العضلة أكتر و بتعطينا قوة أكتر in the + +136 +00:10:28,380 --> 00:10:33,700 +concentrically contracted state than إذا كان صار + +137 +00:10:33,700 --> 00:10:37,320 +بعد shortening من isometric contraction يعني + +138 +00:10:37,320 --> 00:10:40,540 +العضلة يعني احنا خلينا نفترض ان الـ biceps بتعمل + +139 +00:10:40,540 --> 00:10:43,240 +affliction. احنا بدنا نعمل affliction against + +140 +00:10:43,240 --> 00:10:49,360 +resistance لمين؟ للـ biceps فاحنالو بدينا الـ .. الـ + +141 +00:10:49,360 --> 00:10:53,280 +.. الـ concentric work هذا من stretch hand يعني من + +142 +00:10:53,280 --> 00:10:57,400 +full extension لقى القلب و عملنا stretch و قولنا + +143 +00:10:57,400 --> 00:11:01,880 +لأ المريض يلا go اعمل الـ concentric contraction + +144 +00:11:01,880 --> 00:11:04,860 +بنحس حالنا الـ contraction اللى developed أو الـ + +145 +00:11:04,860 --> 00:11:09,600 +tension اللى developed أكتر بتحتاج العضلة لقوة كمان + +146 +00:11:09,600 --> 00:11:12,760 +على أنها تعمل و أكتر من أننا نبدأ من isometric + +147 +00:11:12,760 --> 00:11:16,800 +contraction و نكمل يعني في نص الطريق مثلا يكون + +148 +00:11:16,800 --> 00:11:22,460 +الشخص و نقوله اتني يبقى this is accounted for + +149 +00:11:23,640 --> 00:11:26,860 +باستخدام الطاقة الإلاستيكية المستخدمة في المجموعات + +150 +00:11:26,860 --> 00:11:32,240 +الإلاستيكية من خلال إطلاق وإطلاق وإطلاق وإطلاق + +151 +00:11:32,240 --> 00:11:35,200 +وإطلاق وإطلاق وإطلاق وإطلاق وإطلاق وإطلاق و + +152 +00:11:35,200 --> 00:11:36,040 +إطلاق وإطلاق وإطلاق وإطلاق وإطلاق وإطلاق و + +153 +00:11:36,040 --> 00:11:36,920 +إطلاق وإطلاق وإطلاق وإطلاق وإطلاق وإطلاق و + +154 +00:11:36,920 --> 00:11:37,260 +إطلاق وإطلاق وإطلاق وإطلاق وإطلاق وإطلاق و + +155 +00:11:37,260 --> 00:11:38,640 +إطلاق وإطلاق وإطلاق وإطلاق وإطلاق وإطلاق و + +156 +00:11:38,640 --> 00:11:43,060 +إطلاق وإطلاق وإطلاق وإطفي هنا force-time + +157 +00:11:43,060 --> 00:11:46,960 +relationship يعني علاقة بين القوة اللي بدها .. + +158 +00:11:46,960 --> 00:11:50,780 +اللي بدها تظهر علنا وبين الـ time، احنا بنعرف انه + +159 +00:11:50,780 --> 00:11:53,780 +دايما الـ eccentric contraction اللي هو الـ .. الـ + +160 +00:11:53,780 --> 00:11:57,440 +lengthening contraction بيعطيني energy أكتر و هو + +161 +00:11:57,440 --> 00:12:02,420 +أبطأ فبيعطيني قوة أكتر طيب for generated by the + +162 +00:12:02,420 --> 00:12:06,160 +muscle is proportional force generated by the + +163 +00:12:06,160 --> 00:12:09,560 +muscle proportional to the contraction time يبقى + +164 +00:12:09,560 --> 00:12:12,460 +longer the time required for the muscle to + +165 +00:12:12,460 --> 00:12:16,660 +contract a greater the force developed up to the + +166 +00:12:16,660 --> 00:12:19,860 +point of maximal tension لحد ما يصير الـ + +167 +00:12:19,860 --> 00:12:24,360 +contraction وصل آخره يبقى slower contraction في الـ + +168 +00:12:24,360 --> 00:12:29,100 +eccentric زي الـ eccentric work وهي تسبب في أكتر + +169 +00:12:29,100 --> 00:12:36,460 +إجراء قوة لأن الوقت المسموح لهذا الانتقال أطول من + +170 +00:12:36,460 --> 00:12:44,560 +الوضع الانتقالي للوضع الانتقالي الانتقالي للوضع + +171 +00:12:44,560 --> 00:12:49,760 +الانتقالي في عندنا فرصة ليصير generation لها force + +172 +00:12:49,760 --> 00:12:53,220 +أكبر طبعاً there is a time delay between the + +173 +00:12:53,220 --> 00:12:56,200 +tension developed في الـ active component + +174 +00:12:56,200 --> 00:12:59,600 +والdeveloped في الـ non-contractile component طبعاً + +175 +00:12:59,600 --> 00:13:03,960 +في وقت ليصير الـ twitch هذا ما بين الـ contractile و + +176 +00:13:03,960 --> 00:13:09,480 +الـ non-contractile elements طبعا فيه هنا حاجة اسمها + +177 +00:13:09,480 --> 00:13:15,220 +fatigue، بنتعرض لها لما بيصير في عندنا يعني + +178 +00:13:15,220 --> 00:13:19,520 +contraction متكرر، طبعا احنا بنعرف انه عشان احنا + +179 +00:13:19,520 --> 00:13:22,520 +العضلة تبدأ contraction و تعمل release + +180 +00:13:22,520 --> 00:13:28,340 +للـ contraction، في حاجة اسمها ATP الـ ATP له أدينوين + +181 +00:13:28,340 --> 00:13:33,120 +أدينوسين الـ triphosphate هذا الـ chemical substance + +182 +00:13:33,120 --> 00:13:36,260 +بتعملها الـ synthesis العضلة عشان هي بتعمل الـ + +183 +00:13:36,260 --> 00:13:40,040 +twitch بتخلي العضلة تعمل contraction عشان العضلة + +184 +00:13:40,040 --> 00:13:43,040 +تصير لها contraction بلزمها ATP وعشان تعمل release + +185 +00:13:43,040 --> 00:13:48,060 +للـ contraction بلزمها ATP فهنا بتصير أن المشكلة + +186 +00:13:48,060 --> 00:13:52,560 +when if a muscle has an adequate supply of oxygen + +187 +00:13:52,560 --> 00:13:57,880 +and nutrition that can be broken down عشان يصير هذه + +188 +00:13:57,880 --> 00:14:02,240 +عملية ايش؟ metabolism أو metabolic process بحتاج الـ + +189 +00:14:02,240 --> 00:14:06,320 +oxygen و الـ nutrients عشان يتحول هذه الـ nutrients + +190 +00:14:06,320 --> 00:14:11,920 +لـ ATP can be sustained a series مجموعة من الـ low + +191 +00:14:11,920 --> 00:14:18,020 +frequency which is a response for a long time يعني + +192 +00:14:18,020 --> 00:14:22,180 +احنا نتكلم عن many activity أو many contraction + +193 +00:14:22,180 --> 00:14:28,300 +على الـ term أو على الـ long time طب الـ frequency + +194 +00:14:28,300 --> 00:14:33,360 +must be long enough to allow synthesis للـ ATP يبقى + +195 +00:14:33,360 --> 00:14:37,640 +انا عشان انا يعني اذا بتذكروا احنا دايما تعليماتنا + +196 +00:14:37,640 --> 00:14:40,680 +لازم نعمل contraction و يبقى عندي وقت مضاعف للـ + +197 +00:14:40,680 --> 00:14:44,460 +release للـ contraction عشان نعطي فرصة للـ ATP انه + +198 +00:14:44,460 --> 00:14:50,220 +يتعود يصيرله synthesis مرة تانية The frequency of + +199 +00:14:50,220 --> 00:14:53,440 +the stimulation increases more than the rate of + +200 +00:14:53,440 --> 00:14:57,620 +ATP replacement يعني لو صار فينا تكرار لعملية الـ + +201 +00:14:57,620 --> 00:14:59,800 +contraction + +202 +00:15:03,870 --> 00:15:08,590 +عفوا فبصير الـ ATP فش يعني .. يعني ممكن انه ي .. + +203 +00:15:08,590 --> 00:15:11,910 +يعني يقل لدرجة انه ينعدم الـ ATP فبينعدم بعدها الـ + +204 +00:15:11,910 --> 00:15:15,090 +contraction، بصير فيش قدرة، بصير drop in the + +205 +00:15:15,090 --> 00:15:18,670 +tension followed by a prolonged stimulation of + +206 +00:15:18,670 --> 00:15:23,490 +muscle بتسميه في هذه المرحلة اسمه muscle fatigue + +207 +00:15:26,280 --> 00:15:29,240 +الـ muscle fatigue هذه بتنتج نتيجة الـ metabolic + +208 +00:15:29,240 --> 00:15:32,820 +process اللي بيصيرله failure، بيصير مش قادر، هي + +209 +00:15:32,820 --> 00:15:37,040 +أساسا physiological mechanism بت .. عن طريق الـ + +210 +00:15:37,040 --> 00:15:40,500 +neurotransmitter أو neuromuscular system، هي اللي + +211 +00:15:40,500 --> 00:15:44,400 +بتساعد عملية الـ contraction طب إذا فش ATP كفاية، + +212 +00:15:44,400 --> 00:15:47,820 +معناه إنه بيصير فيش عنا عضلة ماعندهاش القدرة على + +213 +00:15:47,820 --> 00:15:52,680 +إنها تستمر في الـ contraction لما يكون الـ exercise + +214 +00:15:52,680 --> 00:15:57,180 +when an exercising muscle begins to fatigue، a + +215 +00:15:57,180 --> 00:16:00,640 +rest period allows this muscle to resume its + +216 +00:16:00,640 --> 00:16:04,120 +normal performance level، وهذا اللي إحنا متعودين + +217 +00:16:04,120 --> 00:16:07,960 +فيه during exercising لـ our patient or ourselves + +218 +00:16:07,960 --> 00:16:11,960 +as well، إنه إحنا بنعطي وقت للـ rest قد الوقت أو + +219 +00:16:11,960 --> 00:16:18,050 +أكتر شوية من وقت الـ contraction نفسه القضاء اللي + +220 +00:16:18,050 --> 00:16:24,450 +يتطلبه يعتمد على الوقت والضرورة وانتصار التدخل حسب + +221 +00:16:24,450 --> 00:16:27,070 +التدخل اللي احنا عملناه طبعا نشوف الـ example + +222 +00:16:27,070 --> 00:16:31,470 +البسيط هنا احنا بنقول انه كل مكان اللي احنا مثلا + +223 +00:16:31,470 --> 00:16:37,990 +حملنا يعني خلنا نقول box كبير أو شنطة تقيلة تمام؟ + +224 +00:16:37,990 --> 00:16:41,670 +حملناها short duration فبنلاقي الـ recovery كمان + +225 +00:16:41,670 --> 00:16:45,950 +بتكون بتاخد short duration as second لو حملنا فترة + +226 +00:16:45,950 --> 00:16:51,250 +طويلة حملنا كيس مثلا ومشينا فيه مشوار طويل اه + +227 +00:16:51,250 --> 00:16:56,150 +فبنحتاج وقت أطول لانعاود ان نتخلص من الـ fatigue + +228 +00:16:56,150 --> 00:17:00,630 +ability هذه اللي صارت عندنا يبقى الـ muscle that is + +229 +00:17:00,630 --> 00:17:05,250 +rapidly fatigued by high intensity and short + +230 +00:17:05,250 --> 00:17:08,690 +duration exercise recovered after a rest of + +231 +00:17:08,690 --> 00:17:12,130 +seconds or minutes لكن لو كان في عندنا prolonged + +232 +00:17:13,200 --> 00:17:16,980 +أكتر فترة يبقى muscle that is slowly fatigued by + +233 +00:17:16,980 --> 00:17:20,920 +low intensity long duration exercise بتعطينا + +234 +00:17:20,920 --> 00:17:26,400 +بنحتاج لأكثر من 24 ساعة لإنه يصير في عنا recovery + +235 +00:17:26,400 --> 00:17:31,440 +لهذه العضلة نروح لموضوع شوية يعني خلّين .. يمكن أنا + +236 +00:17:31,440 --> 00:17:35,500 +بعتبره معقد لأنه ما هو سهل شرحه على .. بهذه + +237 +00:17:35,500 --> 00:17:39,200 +الطريقة، بدنا نحاول مع بعض نتعرف على الـ Turk أو الـ + +238 +00:17:39,200 --> 00:17:42,980 +moment اللي هو عزم الإزدواج اللي ممكن يكون موجود + +239 +00:17:42,980 --> 00:17:48,320 +على العضلة، الـ Turk هو احنا بنعرفه العزم The + +240 +00:17:48,320 --> 00:17:51,640 +ability of the muscle to rotate the segment around + +241 +00:17:51,640 --> 00:17:54,920 +the joint هلقت العضلة إيش وظيفتها؟ إنها تعمل + +242 +00:17:54,920 --> 00:18:01,880 +contraction إنها يا إما تزودلي الـ .. تزود الزاوية + +243 +00:18:01,880 --> 00:18:07,620 +بين العظام أو تقرب الزاوية بين العظام يعني أنا + +244 +00:18:07,620 --> 00:18:10,980 +عشان أعمل muscle contraction في الـ biceps أنا بلزم + +245 +00:18:10,980 --> 00:18:15,450 +إنه تصير في عندي decreasing للزاوية اللي بتروح في + +246 +00:18:15,450 --> 00:18:19,310 +اتجاه الـ reflection و اللي بتبعد عن الـ .. الـ .. + +247 +00:18:19,310 --> 00:18:24,390 +الزاوية اللي في اتجاه الـ extension يعني احنا بنقول + +248 +00:18:24,390 --> 00:18:27,530 +reflection مية و خمسة و عشرين درجة يعني زاوية الـ + +249 +00:18:27,530 --> 00:18:30,790 +reflection هذه بتزيد هذه هو الحاجة احنا بدنا + +250 +00:18:30,790 --> 00:18:34,650 +نفهمها الـ torque هو عبارة عن ايش؟ العزم هو عبارة + +251 +00:18:34,650 --> 00:18:39,870 +عن الـ force الـ force ضرب عزم الازدواج أو ضرب الـ + +252 +00:18:39,870 --> 00:18:44,940 +moment of arm اللي هو ذراع القوة طيب الـ force قداش + +253 +00:18:44,940 --> 00:18:49,400 +فيه exerted force من العضلة و قداش فيه ذراع لهدي + +254 +00:18:49,400 --> 00:18:53,280 +القوة، قداش الـ attachment هدا بيكون بعيد زي ما + +255 +00:18:53,280 --> 00:18:59,180 +احنا شايفين هنا في ..الصورة هي عندنا المركز وهنا + +256 +00:18:59,180 --> 00:19:03,240 +الـ .. هنا الحركة بدها تصير الـ direction of + +257 +00:19:03,240 --> 00:19:06,920 +rotation وهنا الـ force اللي بت .. بت .. بتساعدها + +258 +00:19:06,920 --> 00:19:10,400 +فهي المسافة عبارة عن إيه؟ القوة اللي ناتجة أو الـ + +259 +00:19:10,400 --> 00:19:13,200 +torque اللي نازل عبارة عن الـ force هنا مضروبة + +260 +00:19:13,200 --> 00:19:17,000 +بالمسافة هادي لإن هنا هي الـ Falcon تبعنا وهي الـ + +261 +00:19:17,000 --> 00:19:21,700 +torque arm اللي هو ذراع الـ .. القوة اللي موجود + +262 +00:19:21,700 --> 00:19:25,480 +عندنا وهي القوة بتنضرب هادي في هادي فبيعطينا العزم + +263 +00:19:25,480 --> 00:19:31,580 +الإزدواج اللي احنابنبتغي أو القوة اللي سايرة الـ + +264 +00:19:31,580 --> 00:19:34,780 +Torque Angle Curve طبعاً في عنا نوع تلت أنواع في + +265 +00:19:34,780 --> 00:19:37,940 +عنا الـ Ascending Relationship وعنا الـ Descending + +266 +00:19:37,940 --> 00:19:41,980 +Relationship وفي عنا الـ Ascending and Descending + +267 +00:19:41,980 --> 00:19:47,640 +مع بعض يعني بتبدأ في أنها بزيد العزم أو بعدين بيقل + +268 +00:19:47,640 --> 00:19:51,640 +طبعا دي علاقة بين الـ Torque و بين الـ Joint Angle + +269 +00:19:51,640 --> 00:19:57,750 +اللي بدها تحصل نتيجة القوة العضلية أو الحركة اللى + +270 +00:19:57,750 --> 00:20:02,890 +قامت فيها العضلة الـ Ascending relation الـ joint + +271 +00:20:02,890 --> 00:20:07,490 +كل ما بتزيد الـ joint ankle بيزيد الـ torque يبقى in + +272 +00:20:07,490 --> 00:20:10,510 +this case زي الـ knee flexor فيه أو الـ hip + +273 +00:20:10,510 --> 00:20:16,110 +adductors عضلات طويلة هذه فهى بيكون العزم تبعها كل + +274 +00:20:16,110 --> 00:20:21,010 +ما زادت الزاوية كل ما زاد العزم تبعها أو الـ torque + +275 +00:20:21,010 --> 00:20:25,300 +تبعها الـ descending لأ بتكون عضلات عنا قصيرة شوية + +276 +00:20:25,300 --> 00:20:30,020 +يبقى as the joint angle increase الـ torque بصير + +277 +00:20:30,020 --> 00:20:34,840 +فيه decrease يعني بتزيد الـ .. الـ .. بتكون علاقة + +278 +00:20:34,840 --> 00:20:41,730 +عكسية زي الـ hip abductors زي الـ gluteus medius و + +279 +00:20:41,730 --> 00:20:44,870 +الـ internal .. the internal torque of the muscle + +280 +00:20:44,870 --> 00:20:48,150 +is the greatest at the frontal plane، الـ angle + +281 +00:20:48,150 --> 00:20:53,130 +بتصير على الـ minus عشرة degree towards abduction + +282 +00:20:55,870 --> 00:20:59,230 +هذا الرسم بيوضح كيف العلاقة لما تكون ascending + +283 +00:20:59,230 --> 00:21:03,690 +بتزيد و بعدين بتعود بتقل هنا العلاقة لما تكون + +284 +00:21:03,690 --> 00:21:08,250 +descending و هنا العلاقة لما بتكون ascending بتكون + +285 +00:21:08,250 --> 00:21:12,370 +شوفوا فيه زيادة في الـ angle و كمان زيادة في الـ + +286 +00:21:12,370 --> 00:21:16,830 +torque In ascending descending relationship في الـ + +287 +00:21:16,830 --> 00:21:19,530 +elbow joint الـ elbow flexor اللي كنا بتكلم عنها + +288 +00:21:19,530 --> 00:21:23,510 +احنا قبل شوية الـ biceps الـ first part of the range + +289 +00:21:23,510 --> 00:21:26,610 +of the joint movement as the joint of flexion + +290 +00:21:26,610 --> 00:21:31,690 +increase الـ elbow flexor torque بزيد في هذا الـ + +291 +00:21:31,690 --> 00:21:35,690 +part بيكون الـ degrees in the muscle length and + +292 +00:21:35,690 --> 00:21:39,970 +increase in the muscle in the moment arm بزيد الـ + +293 +00:21:39,970 --> 00:21:43,570 +moment arm في الـ internal torque of the elbow + +294 +00:21:43,570 --> 00:21:50,410 +flexor، greatest at 75 درجة of inflection في الـ + +295 +00:21:50,410 --> 00:21:53,730 +second part، هالقتا بيصير عند 75، بيكون العضلة + +296 +00:21:53,730 --> 00:21:57,710 +فيها قوة و الـ torque فيها لسه ما زال كويس، في الـ + +297 +00:21:57,710 --> 00:22:00,510 +.. في الـ .. في المرحلة التانية، في الـ second part، + +298 +00:22:00,510 --> 00:22:04,370 +بتبدأ تقصر خيوط العضلة كتير، the range of movement + +299 +00:22:04,370 --> 00:22:08,080 +as the joint angle increase الـ torque بصير في + +300 +00:22:08,080 --> 00:22:11,740 +decrease other example في الـ body بصير في الـ + +301 +00:22:11,740 --> 00:22:18,500 +extension of the knee و الـ extension of the elbow + +302 +00:22:20,040 --> 00:22:25,360 +هنا إيش بنستفيد من هذا الكلام؟ بنستفيد إنه في بعض + +303 +00:22:25,360 --> 00:22:29,960 +الحالات عندنا أحيانا بيكون فيه قلم زي القلم بالـ + +304 +00:22:29,960 --> 00:22:36,040 +hip بيصير في عندنا الأطباء بيروحوا بي .. بيلعبوا + +305 +00:22:36,040 --> 00:22:41,840 +بالـ .. الـ greater أو الـ attachment تبع العضلة + +306 +00:22:41,840 --> 00:22:47,900 +surgical displacement of the greater atrocantar to + +307 +00:22:47,900 --> 00:22:48,760 +increase + +308 +00:22:53,530 --> 00:22:59,330 +العضلة الداخلية تقوم بتقليجيات عضلات العضلات + +309 +00:22:59,330 --> 00:23:05,130 +المحتاجة لإيجاد مستوى عضلات العضلات المحتاجة + +310 +00:23:05,130 --> 00:23:08,370 +لإيجاد مستوى عضلات العضلات + +311 +00:23:09,380 --> 00:23:13,400 +في عندنا مشكلة إن هي عضلة صغيرة و الـ attachment + +312 +00:23:13,400 --> 00:23:17,540 +تبعها على greater retro counter و لما يكون العزم + +313 +00:23:17,540 --> 00:23:21,400 +هنا قليل بتحتاج .. احنا كل ما زاد دراعي القوة كل + +314 +00:23:21,400 --> 00:23:26,000 +ما نضرب فيه القوة محتاج force من العضلة عشان تعمل + +315 +00:23:26,000 --> 00:23:31,580 +ال contraction أقل لأنها بتنضرب بال movement arm + +316 +00:23:31,580 --> 00:23:36,710 +فبتزيد القوة فهيقل الوجع فهم بيلعبوا بيحركوا في الـ + +317 +00:23:36,710 --> 00:23:40,110 +attachment تبعت العضلة as a consequence of the + +318 +00:23:40,110 --> 00:23:44,110 +decreased hip abductor force can reduce the force + +319 +00:23:44,110 --> 00:23:47,650 +generated across the unstable or painful hip joint + +320 +00:23:47,650 --> 00:23:51,510 +which considered a means of protection of the + +321 +00:23:51,510 --> 00:23:56,450 +joint from damaging force في البتليكتومي following + +322 +00:23:56,450 --> 00:24:00,050 +severe fracture لما بيصير فيه بيقع شخص مثلا على + +323 +00:24:00,050 --> 00:24:04,890 +ركبته مباشرة و بيصير فيه fracture في البتلة + +324 +00:24:05,360 --> 00:24:09,140 +Internal moment arm lead to an increase in the + +325 +00:24:09,140 --> 00:24:14,340 +amount of knee extensor بيصير أنه عضلة الرباعية أو + +326 +00:24:14,340 --> 00:24:18,680 +الـ quadriceps بتحتاج قوة أكتر عشان تعملي الـ + +327 +00:24:18,680 --> 00:24:24,020 +extension، تمام؟ فهنا بيعملي wear and tear على الـ + +328 +00:24:24,020 --> 00:24:30,700 +knee joint نروح للنقطة الخامسة اللي هي الـ velocity + +329 +00:24:30,700 --> 00:24:34,540 +أو السرعة، السرعة انتوا عارفين احنا measured by + +330 +00:24:34,540 --> 00:24:39,980 +centimeter per second هذه السرعة الـ muscle defined + +331 +00:24:39,980 --> 00:24:43,260 +الـ velocity of the muscle is defined as الـ rate of + +332 +00:24:43,260 --> 00:24:46,880 +changing in muscle length كده بيصير الـ rate + +333 +00:24:46,880 --> 00:24:51,240 +لتغيير الـ length of the muscle طبعا الـ force + +334 +00:24:51,240 --> 00:24:54,680 +velocity relationship بنشوف احنا العلاقة ما بين الـ + +335 +00:24:54,680 --> 00:24:57,120 +force و ما بين الـ length في الـ isometric + +336 +00:24:57,120 --> 00:25:03,080 +contraction بتكون صفر zero velocity ليش لأنه لا في + +337 +00:25:03,080 --> 00:25:08,380 +عندنا تغيير في الطول ولا في عندنا و العزم بيصير + +338 +00:25:08,380 --> 00:25:15,510 +فيها صفر يبقى at the velocity of .. السرعة قصد صفر + +339 +00:25:15,510 --> 00:25:19,450 +at the velocity of the shortening increase الـ + +340 +00:25:19,450 --> 00:25:23,790 +amount of torque will decrease الـ torque إذا زادت + +341 +00:25:23,790 --> 00:25:26,630 +السرعة بيقل الـ torque وهذا اللي احنا بنشوفه في الـ + +342 +00:25:26,630 --> 00:25:30,650 +concentric contraction لما يكون مافيش عندنا حركة و + +343 +00:25:30,650 --> 00:25:34,330 +مافيش عندنا .. مافيش فيه سرعة في الـ at zero + +344 +00:25:34,330 --> 00:25:37,010 +velocity هنا في الـ contraction الـ muscle can + +345 +00:25:37,010 --> 00:25:43,190 +produce high torque زي ما احنا شايفينه هنا في هذه + +346 +00:25:43,190 --> 00:25:49,510 +النقطة في الـ isometric contraction فلده في الـ + +347 +00:25:49,510 --> 00:25:55,350 +lengthening هتختلف الأمور يبقى at high velocity or + +348 +00:25:55,350 --> 00:25:59,330 +in case of concentric contraction الـ muscle + +349 +00:25:59,330 --> 00:26:04,650 +produces lower torque أقل torque than in case of + +350 +00:26:04,650 --> 00:26:07,910 +isometric contraction + +351 +00:26:10,790 --> 00:26:15,550 +إذا زادت السرعات تزداد ترق المضمون في المضمون تتخلص + +352 +00:26:15,550 --> 00:26:22,970 +حتى يوصل إلى أقل في أقل سرعات وبتوصل السفر يبقى في + +353 +00:26:22,970 --> 00:26:28,990 +أقل سرعات أو في حالة مضمون أساسي المضمون يتخلص + +354 +00:26:28,990 --> 00:26:33,390 +المضمون من ترق أعلى than in case of isometric + +355 +00:26:33,390 --> 00:26:37,630 +contraction إذا الـ velocity of the contraction هنا + +356 +00:26:37,630 --> 00:26:44,690 +بتزيد الـ torque بتقل يبقى الـ torque بيزيد لحد ما + +357 +00:26:44,690 --> 00:26:48,490 +الـ torque بصير maximum في الـ minimum velocity + +358 +00:26:48,490 --> 00:26:52,750 +وإحنا عارفين إنه اللي إحنا بنعمل exertion لقوة + +359 +00:26:52,750 --> 00:26:56,070 +أكبر في الـ eccentric contraction than الـ + +360 +00:26:56,070 --> 00:27:05,250 +concentric contraction هي أنه هنا الترق بيزيد نروح + +361 +00:27:05,250 --> 00:27:09,610 +لحاجة اسمها الـ power أو الـ muscle power هي قدرة + +362 +00:27:09,610 --> 00:27:13,810 +العضلة الـ rate of doing work على انها تعمل على + +363 +00:27:13,810 --> 00:27:18,790 +العمل and is expressed as the product of force, + +364 +00:27:19,530 --> 00:27:24,160 +time, contraction, velocity كيف بنعبر عنها بالـ + +365 +00:27:24,160 --> 00:27:29,960 +equation الـ power بتساوي الـ work على الـ time يبقى + +366 +00:27:29,960 --> 00:27:34,140 +الـ work output that is a muscle must be able to + +367 +00:27:34,140 --> 00:27:39,940 +contract forcibly and with high velocity to have a + +368 +00:27:39,940 --> 00:27:45,870 +higher power output يعني احنا عادة بنقس قوة الأشياء + +369 +00:27:45,870 --> 00:27:51,270 +بقداش قدرتها على العمل، قداش الـ output تبعها، يبقى + +370 +00:27:51,270 --> 00:27:58,580 +الـ work تعني لي قداش ممكن تعمل work على الـ time طب + +371 +00:27:58,580 --> 00:28:01,780 +الـ work لحاله بنعبّر عليه بالـ equation الـ force + +372 +00:28:01,780 --> 00:28:06,280 +ضرب الـ distance طيب الـ power بتساوي الـ force ضرب + +373 +00:28:06,280 --> 00:28:08,900 +الـ distance على الـ time الـ distance على الـ time + +374 +00:28:08,900 --> 00:28:12,320 +هادي عبارة عن الـ velocity فبالتالي الـ power بتصير + +375 +00:28:12,320 --> 00:28:16,730 +بتساوي الـ force ضرب الـ velocity فينا نوعين من الـ + +376 +00:28:16,730 --> 00:28:20,210 +work ممكن تعملهم العضلة، ال positive work و ال + +377 +00:28:20,210 --> 00:28:23,750 +negative work، طب ال positive work هو عبارة عن + +378 +00:28:23,750 --> 00:28:29,490 +ايش؟ هو contraction .. contraction against the load + +379 +00:28:30,510 --> 00:28:33,090 +يعني أنا بكون في عينة concentric أنا حاملة بإيدي + +380 +00:28:33,090 --> 00:28:37,370 +مثلا dumbbell و بعمل biceps concentric contraction + +381 +00:28:37,370 --> 00:28:41,230 +هي the result of positive work بنسميها power + +382 +00:28:41,230 --> 00:28:46,680 +production يعني أنا بقوي العضلة طبعا؟أما ال + +383 +00:28:46,680 --> 00:28:49,080 +negative work بروح فيه عن طريق ال eccentric + +384 +00:28:49,080 --> 00:28:52,480 +contraction يعني انا suppose اني انا حاملة بإيدي + +385 +00:28:52,480 --> 00:28:58,100 +عشرة كيلو و قاعدة بحاول أنزلهم شوية شوية على ال .. + +386 +00:28:58,100 --> 00:29:01,500 +على جنبي يعني انا من biceps contraction يعني بتكون + +387 +00:29:01,500 --> 00:29:04,980 +انا ماسكة ب the friction of the elbow و قاعدة بنزل هنا + +388 +00:29:04,980 --> 00:29:08,860 +بتصير الحركة slowly و بصير فيها storage لل energy + +389 +00:29:08,860 --> 00:29:12,260 +لإن أنا بعمل eccentric work فبتسمى power + +390 +00:29:12,260 --> 00:29:18,710 +absorption يبقى ال negative work طبعا during the + +391 +00:29:18,710 --> 00:29:22,430 +isometric contraction the muscle experiences + +392 +00:29:22,430 --> 00:29:29,230 +metabolic work بيصير فيها يعني تجمع لخلينا نقول + +393 +00:29:29,230 --> 00:29:34,830 +الدم و ال nutrition because the activation of the + +394 +00:29:34,830 --> 00:29:39,020 +muscle involves expenditure of energy ATP but no + +395 +00:29:39,020 --> 00:29:42,560 +mechanical work is produced لأنه مافيش حركة + +396 +00:29:42,560 --> 00:29:46,080 +mechanical work يعني فيش حركة يعني صح احنا بنعمل + +397 +00:29:46,080 --> 00:29:50,160 +isometric contraction ل .. اه لكن الحركة مافي .. + +398 +00:29:50,160 --> 00:29:54,320 +مافي حركة يعني ال ATP يعني العضلة ال ATP هنا بيصير + +399 +00:29:54,320 --> 00:30:00,020 +في .. يعني بيتعرض لإنه بدنا ATP لكن حقيقي مافيش + +400 +00:30:00,020 --> 00:30:00,980 +عندنا حركة + +401 +00:30:04,640 --> 00:30:09,040 +الروح لأخر إشي معناه اللى هى ال muscle length هو + +402 +00:30:09,040 --> 00:30:14,680 +كيف احنا يعني بأثر the muscle sorry the muscle + +403 +00:30:14,680 --> 00:30:18,080 +strength كيف احنا بنعمل improving لل muscle + +404 +00:30:18,080 --> 00:30:21,340 +strength وكيف احنا بنعرف أن هاد العضلة ممكن تكون + +405 +00:30:21,340 --> 00:30:25,060 +قوية أو لأ عندنا the muscle strength is the maximum + +406 +00:30:25,060 --> 00:30:30,060 +amount of force exerted by the muscle قداش قدرة + +407 +00:30:30,060 --> 00:30:36,030 +العضلةأكتر إشي ممكن تتحمله العضلة، يعني the muscle + +408 +00:30:36,030 --> 00:30:39,570 +length بتاعي أنا أديش بقدر أحمل خمسة كيلو، عشرة + +409 +00:30:39,570 --> 00:30:43,770 +كيلو، خمستاشر كيلو بال biceps، هذه اسمها muscle + +410 +00:30:43,770 --> 00:30:46,770 +strength هو directly proportional to the + +411 +00:30:46,770 --> 00:30:50,270 +physiological cross-section due to physiological + +412 +00:30:50,270 --> 00:30:54,140 +hypertrophy زي عضلة الـ Quadriceps احنا بنشوفها + +413 +00:30:54,140 --> 00:30:58,000 +عضلة .. هي عضلة ربعية و عضلة كتير the diameter + +414 +00:30:58,000 --> 00:31:01,960 +تبعها كبير يعني the hypertrophy هنا increase + +415 +00:31:01,960 --> 00:31:05,920 +the muscle size بتزود the muscle size و it's usually + +416 +00:31:05,920 --> 00:31:11,940 +additional 30 to 60% بزيد من بال .. عن طريق اللي هو + +417 +00:31:11,940 --> 00:31:15,940 +من 30 ل 60% عن طريق the exercise أو التمرين اللي + +418 +00:31:15,940 --> 00:31:19,720 +بيصير فيه هنا hypertrophy للـ fibers of the + +419 +00:31:19,720 --> 00:31:22,400 +muscle يعني هو عددها مش هو اللي بيزيد هي بيصير + +420 +00:31:22,400 --> 00:31:26,600 +فيها trophy أكتر طبعا هنا العضلات العضلات + +421 +00:31:26,600 --> 00:31:30,260 +الأوية و الكبيرة لما بتصير بتعمل activity activity + +422 +00:31:30,260 --> 00:31:35,360 +مابتعملش activation لكل ال fibers تبعتها يبقى the + +423 +00:31:35,360 --> 00:31:38,920 +stronger muscles are not acting wholly but part act + +424 +00:31:38,920 --> 00:31:42,520 +and other parts are at rest عشان هيك ده this permits + +425 +00:31:42,520 --> 00:31:45,960 +early recovery and allows individuals to do more for + +426 +00:31:45,960 --> 00:31:49,230 +longer periods of time العادلة بتكون كبيرة فبستخدم + +427 +00:31:49,230 --> 00:31:55,090 +جزء من ال fibers و بتخليه جزء و مبدل ما بينهم طبعا + +428 +00:31:55,090 --> 00:31:57,990 +نتكلم عن حاجة اسمها muscle endurance اللي احنا + +429 +00:31:57,990 --> 00:32:00,770 +صارنا في عندنا muscle power و في عندنا muscle + +430 +00:32:00,770 --> 00:32:06,570 +strength و في عندنا muscle endurance طبعا ال + +431 +00:32:06,570 --> 00:32:11,760 +strength قداش قدرتناإن نشيل يعني عشرة أو خمستاشر + +432 +00:32:11,760 --> 00:32:16,740 +كيلو أما ال endurance قداش إحنا فينا نستمر و إحنا + +433 +00:32:16,740 --> 00:32:19,940 +بنعمل هذا التمرين يعني مش شرط أنا أحمل خمستاشر + +434 +00:32:19,940 --> 00:32:23,460 +كيلو ممكن أحمل خمسة كيلو و أستمر لمدة ساعة و أنا + +435 +00:32:23,460 --> 00:32:26,900 +بمرر إيدي يبقى هي the ability of the muscle to + +436 +00:32:26,900 --> 00:32:31,620 +exert force repeatedly over a period of time بدي + +437 +00:32:31,620 --> 00:32:36,820 +وقت أنا عشان أعمل الحركة هذهالـ endurance training + +438 +00:32:36,820 --> 00:32:41,300 +involves enhancement of muscle energy supply rather + +439 +00:32:41,300 --> 00:32:45,000 +than its size يعني أنا باهتم هنا بال endurance أنا + +440 +00:32:45,000 --> 00:32:48,540 +بدي يكون ال energy supply زي ال ATP أكتر ما أنا + +441 +00:32:48,540 --> 00:32:52,640 +بدي حجم العضلة لإنه الحجم هذا بيعطيني strength لكن + +442 +00:32:52,640 --> 00:32:56,380 +أنا هنا معنية بالطاقة أنا كيف بدي أقدر أستمر في + +443 +00:32:56,380 --> 00:33:00,490 +long term أو long period of exercising يبقى + +444 +00:33:00,490 --> 00:33:05,510 +endurance is related to an increase in muscle + +445 +00:33:05,510 --> 00:33:09,430 +myoglobin concentration, capillary number, and + +446 +00:33:09,430 --> 00:33:15,250 +mitochondrial size and number هنا لإن أنا هنا + +447 +00:33:15,250 --> 00:33:19,410 +معنية بال metabolism أكتر ما أنا معنية بال + +448 +00:33:19,410 --> 00:33:24,580 +strength أو بالحجم يبقى trained muscle is not easy + +449 +00:33:24,580 --> 00:33:28,340 +to fatigue because it utilizes more effective + +450 +00:33:28,340 --> 00:33:33,920 +metabolic reactions as the muscle is oxygenated + +451 +00:33:33,920 --> 00:33:39,040 +through the conditions of the cardiovascular and + +452 +00:33:39,040 --> 00:33:42,460 +respiratory system، ليش؟ لأن the cardiovascular and + +453 +00:33:42,460 --> 00:33:46,480 +respiratory system هما مصادر الـ Oxygen اللي بده + +454 +00:33:46,480 --> 00:33:50,860 +ييجي يساعد في عملية الـ metabolism عن طريق الدم + +455 +00:33:50,860 --> 00:33:56,460 +اللي بيرسله القلب لأجزاء الجسم ومنها العضلة طبعا + +456 +00:33:56,460 --> 00:34:01,310 +the elasticity إشي كتير مهم هو عبارة عن the capacity + +457 +00:34:01,310 --> 00:34:04,950 +to lengthen the muscle sufficiently to move the + +458 +00:34:04,950 --> 00:34:08,030 +joint throughout its range of motion، قداش احنا + +459 +00:34:08,030 --> 00:34:12,330 +ممكن احنا نفرض هذه العضلة و تكون عندها قدرة على + +460 +00:34:12,330 --> 00:34:20,010 +الرجوع لما قبل the stretch أو ال lengthening يبقى + +461 +00:34:20,010 --> 00:34:23,450 +elasticity can be improved by decreasing + +462 +00:34:23,450 --> 00:34:27,290 +the resistance of tight thigh muscles using static + +463 +00:34:27,290 --> 00:34:31,430 +or dynamic stretch techniques or by increasing the + +464 +00:34:31,430 --> 00:34:34,130 +strength of the antagonist يعني يا إما أنا بشد + +465 +00:34:34,130 --> 00:34:37,930 +العضلاء يا إما بأول عضلاء اللي على قبلها عشان أنا + +466 +00:34:37,930 --> 00:34:42,480 +أقدر أزود the elasticity تبعتها as the muscle is + +467 +00:34:42,480 --> 00:34:47,500 +viscoelastic، the elastic property permits spring + +468 +00:34:47,500 --> 00:34:51,220 +-like behavior اللي بيخلّي العضلة ترجع لل original + +469 +00:34:51,220 --> 00:34:56,060 +length بعد ما تكون صار لها stretching، طبعا + +470 +00:34:56,060 --> 00:34:58,960 +the viscosity أو the viscosity property بتخلي حاجة + +471 +00:34:58,960 --> 00:35:02,680 +اسمها plasticity to permanent or permanent + +472 +00:35:02,680 --> 00:35:07,060 +deformation قبل هيك حكينا عن إيش الفرق بين ال + +473 +00:35:07,060 --> 00:35:11,260 +plasticity و ال elasticity ال elasticity هي أنه + +474 +00:35:11,260 --> 00:35:15,480 +يرجع الأشي إلى ما قبل the tension أو ما قبل ال + +475 +00:35:15,480 --> 00:35:20,500 +stretching يعني مقاطعة إحنا شدناها رجعت لوضعها فدي + +476 +00:35:20,500 --> 00:35:24,180 +حاجة أسمها elasticity شدناها كتير مثلا طول الليل + +477 +00:35:24,180 --> 00:35:28,640 +أو لفترة طويلة أو استخدمناها كتير فهي بتروح لحاجة + +478 +00:35:28,640 --> 00:35:32,200 +أسمها plasticity بيصير فيها permanent deformation + +479 +00:35:32,200 --> 00:35:37,600 +وبتغير the length تبعها بعدين عندنا الرقم أربع اللي + +480 +00:35:37,600 --> 00:35:43,420 +هو the increase in muscle efficiency طبعا calculated + +481 +00:35:43,420 --> 00:35:47,860 +as the percentage of energy input that is converted + +482 +00:35:47,860 --> 00:35:52,320 +into work instead of heat قداش بيصير في عندنا + +483 +00:35:52,320 --> 00:35:57,960 +عملية metabolism و energy موجودة بتساعد على عملية + +484 +00:35:57,960 --> 00:36:04,120 +اللي هي the work القوة the efficiency أو القدرة + +485 +00:36:04,120 --> 00:36:10,350 +هنسميها القدرة the efficiency of the muscle is less + +486 +00:36:10,350 --> 00:36:16,030 +than 20 to 25% the reason for this low efficiency + +487 +00:36:16,030 --> 00:36:20,030 +is that about half of the energy in food stuffs + +488 +00:36:20,030 --> 00:36:24,270 +is lost during the formation of ATP لأن هذا ال + +489 +00:36:24,270 --> 00:36:28,310 +energy احنا بنحتاجه عشان عملية ال metabolism اللي + +490 +00:36:28,310 --> 00:36:32,610 +بتساعد على the ATP formation عشان تعملي contraction + +491 +00:36:32,610 --> 00:36:36,910 +and release of the muscle بال exercise the maximum + +492 +00:36:36,910 --> 00:36:40,370 +efficiency of the muscle is developed especially when + +493 +00:36:40,370 --> 00:36:44,970 +the velocity of contraction is about 30% لما بيكون ال + +494 +00:36:44,970 --> 00:36:53,930 +contraction مش كتير أوي أو سريع التجارب أضافت قوة + +495 +00:36:53,930 --> 00:36:58,910 +أسهل للتعب بقليل من التعب، ونعرف أنه كل ما تمرنت + +496 +00:36:58,910 --> 00:37:03,870 +العضلة، كل ما كان في عندنا قدرة على تحميل التعب + +497 +00:37:03,870 --> 00:37:09,050 +لفترة طويلة، تتطور، طبعا في هنا the circle، + +498 +00:37:09,050 --> 00:37:15,070 +the circle لما تصبح ثقر، تزداد عضلات التواصل في عدد + +499 +00:37:15,070 --> 00:37:20,060 +بتصير فيها بتتجدد و بتتحسن there is also a greater + +500 +00:37:20,060 --> 00:37:24,260 +amount of glycogen needed to supply the trend + +501 +00:37:24,260 --> 00:37:27,860 +muscle within the muscle itself عشان تساعد في + +502 +00:37:27,860 --> 00:37:31,400 +عمليات ال metabolism نروح لحاجة اسمها muscle + +503 +00:37:31,400 --> 00:37:34,740 +injury، في عندنا أربعة من ال muscle injury مش + +504 +00:37:34,740 --> 00:37:37,860 +عارفة هنا ناقصة واحدة، عندنا ال acute muscle + +505 +00:37:37,860 --> 00:37:42,500 +strain و ال muscle contusion و ال exercise induced + +506 +00:37:42,500 --> 00:37:47,210 +injury و الرابعة هي ال cramps. الـ acute muscle + +507 +00:37:47,210 --> 00:37:54,030 +strain بيصير نتيجة result from overstretch of + +508 +00:37:54,030 --> 00:37:59,830 +passive muscle or dynamically overloaded and + +509 +00:37:59,830 --> 00:38:03,390 +active muscle سواء كانت concentrically or + +510 +00:38:03,390 --> 00:38:06,130 +eccentrically يعني أنتم عارفين ال muscle strain + +511 +00:38:06,130 --> 00:38:10,290 +بيصير فيه شد مفاجئ في ال fibers تبع العضلة ممكن + +512 +00:38:10,290 --> 00:38:16,930 +أنها تنقطع أو ممكن أنَّها تنشد و .. و تتمزق تنزق جزء + +513 +00:38:16,930 --> 00:38:22,050 +أو .. أو كله سواء كانت إحنا شدينا العضلة بطريقة + +514 +00:38:22,050 --> 00:38:26,730 +عنيفة أو أنَّها كانت بتعمل فعلا يعني Dynamic + +515 +00:38:26,730 --> 00:38:30,150 +contraction أو overloaded يعني نسميها زي ما بيصير + +516 +00:38:30,150 --> 00:38:33,370 +مع لاعيبة الكورة هو بيروح بيشوت الكورة بيعمل sudden + +517 +00:38:33,370 --> 00:38:37,770 +contraction في العضلة أو خلينا نقول vigorous + +518 +00:38:37,770 --> 00:38:42,390 +contraction في العضلة فبيصير فيه تمزق لبعض خيوط + +519 +00:38:42,390 --> 00:38:44,910 +العضلة The severity of the tissue damage depends + +520 +00:38:44,910 --> 00:38:50,120 +on the magnitude of the the rate of the force + +521 +00:38:50,120 --> 00:38:54,740 +application and the strength of the musculotendinous + +522 +00:38:54,740 --> 00:38:59,080 +structure وهذا طبعا شيء طبيعي، طبعا قد إيش ال force + +523 +00:38:59,080 --> 00:39:04,260 +exerted، قد إيش ال rate، كام مرة، ال strength بتاعت + +524 +00:39:04,260 --> 00:39:08,180 +العضلة أو ال musculotendinous structure اللي هو + +525 +00:39:08,180 --> 00:39:11,320 +خليني أقول التناغم والانسجام بين ال contractile و + +526 +00:39:11,320 --> 00:39:15,200 +ال non contractile elements اللي موجودة في العضلة + +527 +00:39:15,480 --> 00:39:18,820 +طبعاً إلها تلاتة من الـ grades الـ mild والمُدرجة + +528 +00:39:18,820 --> 00:39:22,500 +والسيفير الـ mild are characterized by minimal + +529 +00:39:22,500 --> 00:39:26,260 +structural disruption and rapid return to the + +530 +00:39:26,260 --> 00:39:31,020 +normal function وهذه يعني يدوب يكون فيها شوية + +531 +00:39:31,020 --> 00:39:35,040 +خلينا نقول تمزق ال moderate associated with + +532 +00:39:35,040 --> 00:39:41,140 +partial tear مثل ما يحدث في العضلة عادة قريب من + +533 +00:39:41,140 --> 00:39:46,240 +الـmyotendinous يعني جانكشن بين العضلة والتندون + +534 +00:39:46,240 --> 00:39:51,360 +وبين بعض الاختلافات الفنقشن أما severe فهي complete + +535 +00:39:51,360 --> 00:39:55,010 +أو near complete tissue disruption فيها انقطاع + +536 +00:39:55,010 --> 00:39:58,590 +وكمان عندنا complete functional loss وعندنا marked + +537 +00:39:58,590 --> 00:40:03,510 +hemorrhage and swelling لأنه بيصير فيه هروب للدم + +538 +00:40:03,510 --> 00:40:09,160 +لأنه صار قطع في الأنسجة تبع العضلة أما ال muscle + +539 +00:40:09,160 --> 00:40:13,020 +contusion كلنا بنتعرض له وخاصة اللاعبين الكورة أو + +540 +00:40:13,020 --> 00:40:15,700 +اللاعبين الرياضيين اللي بتعرضوا أو اللاعبين ال + +541 +00:40:15,700 --> 00:40:18,940 +boxers وغيرهم يتبعون ال basketball و ال football + +542 +00:40:18,940 --> 00:40:21,820 +لما بيكونوا بيخبطوا و بيقعدوا اللاعبين يخبطوا في + +543 +00:40:21,820 --> 00:40:24,720 +بعضهم ال muscle contusion ال muscle injury + +544 +00:40:24,720 --> 00:40:28,070 +happened as a result of direct compression + +545 +00:40:28,070 --> 00:40:30,990 +impact which causes intramuscular hemorrhage، + +546 +00:40:30,990 --> 00:40:34,070 +الضربات اللي إحنا بنشوفها في رجلنا وفي إيدينا، + +547 +00:40:34,070 --> 00:40:37,110 +نتيجة للخدوش اللي إحنا بناخدها وإحنا مش دارين + +548 +00:40:37,110 --> 00:40:41,350 +بينا أو اللاعبين الكورة لما الathletes بيدربوا في + +549 +00:40:41,350 --> 00:40:47,590 +بعضهم وبتصير في عندهم ال muscle contusion أما ال + +550 +00:40:47,590 --> 00:40:52,110 +exercise induced injury فهذه اللي بتفضلوا حضراتكوا + +551 +00:40:52,110 --> 00:40:55,410 +بتروحوا على الجيمات وأول ما بتبدؤوا بتبدؤوا بخمسين + +552 +00:40:55,410 --> 00:41:03,270 +squat وخمسين push up وخمسين curl وخمسين set ups + +553 +00:41:03,270 --> 00:41:07,430 +فبتلاقوا بتروحوا أول يوم بتكونوا حلوين ومبسوطين، + +554 +00:41:07,430 --> 00:41:10,270 +تاني يوم بتلاقوا بيصبح muscle soreness، بتبدأ + +555 +00:41:10,270 --> 00:41:14,410 +عضلات بطنكم توجعكم، بتصيروا من الدحكة تعيطوا، + +556 +00:41:14,410 --> 00:41:18,970 +فأكيد هذا بيصير ال exercise induced injury نتيجة + +557 +00:41:18,970 --> 00:41:25,040 +التمرين المفاجئ والغير معتاد هذا في فترة قصيرة يبقى + +558 +00:41:25,040 --> 00:41:29,700 +الـ injury results from connective and contractile + +559 +00:41:29,700 --> 00:41:33,180 +tissue disruption following exercise characterized + +560 +00:41:33,180 --> 00:41:36,240 +by local tenderness with stiffness restriction للـ + +561 +00:41:36,240 --> 00:41:39,000 +range of motion بيصيروا مش قادرين تعدلوا بطنكم أو + +562 +00:41:39,000 --> 00:41:43,680 +تعدلوا ظهركم. This type of injury referred to as + +563 +00:41:43,680 --> 00:41:48,540 +delayed onset بتبدأ الصرنس، الألم بعد 24 ساعة أو + +564 +00:41:48,540 --> 00:41:52,880 +72 ساعة بعد ما participation of vigorous exercise + +565 +00:41:52,880 --> 00:41:57,000 +following eccentric muscle contraction in the + +566 +00:41:57,000 --> 00:42:00,640 +contractile tissue unaccustomed to the activity + +567 +00:42:00,640 --> 00:42:05,160 +demand. آخر حاجة معانا لليوم اللي هي ال muscle + +568 +00:42:05,160 --> 00:42:09,380 +cramps. الـ Muscle Cramps بتصير نتيجة Electrolyte + +569 +00:42:09,380 --> 00:42:14,080 +imbalance. إحنا عارفين إنه المكونات الأساسية لـ الـ + +570 +00:42:14,080 --> 00:42:17,440 +Electrolyte اللي موجودة في العضلات هي الـ Calcium + +571 +00:42:17,440 --> 00:42:21,300 +والمغنيسيوم بيصير imbalance بينهم فبتصير الـ + +572 +00:42:21,300 --> 00:42:24,300 +Cramps موجودة على العضلات خاصة في الـ + +573 +00:42:24,300 --> 00:42:26,660 +Gastrocnemius و الـ Semimembranosis و الـ + +574 +00:42:26,660 --> 00:42:29,920 +Tendinosis و الـ Biceps اللي إحنا بنسميهم كلهم مع + +575 +00:42:29,920 --> 00:42:33,300 +بعض الـ Hamstrings الـ Abdominals أحيانًا and can + +576 +00:42:33,300 --> 00:42:39,140 +be من خلال عملية عملية عملية عملية عملية عملية + +577 +00:42:39,140 --> 00:42:39,980 +عملية عملية عملية عملية عملية عملية عملية + +578 +00:42:39,980 --> 00:42:40,060 +عملية عملية عملية عملية عملية عملية عملية + +579 +00:42:40,060 --> 00:42:41,520 +عملية عملية عملية عملية عملية عملية عملية + +580 +00:42:41,520 --> 00:42:48,320 +عملية عملية عملية عملية عملية عملية عملية + +581 +00:42:48,320 --> 00:42:49,260 +عملية عملية عملية عملية عملية عملية عملية + +582 +00:42:49,260 --> 00:42:54,760 +عملية عملية + +583 +00:42:54,760 --> 00:42:59,680 +عملية + +584 +00:43:00,300 --> 00:43:03,980 +وهيك إحنا بنكون الله يعطينا العافية ويعطيكم + +585 +00:43:03,980 --> 00:43:11,440 +العافية ووصلنا لنهاية محاضرتنا لليوم diff --git a/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/P6Duy9VIIYA_raw.json 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التجسسية الباسيف التنشن بيزيد و ال active tension بيقل لأنه بيصير ال load أكتر على ال non contractile element فبزيد عليها ال tension بتزيد ال tension أما ال active tension فهو بيقل", "tokens": [6027, 9778, 9566, 2407, 3660, 6055, 8592, 13546, 30731, 14739, 3224, 43242, 15042, 7251, 2655, 7435, 3794, 3794, 9673, 9381, 3215, 2288, 4724, 1829, 11536, 3215, 3714, 30543, 3615, 3224, 16712, 7435, 3794, 3794, 10632, 2423, 3555, 32277, 33911, 16712, 1863, 8592, 1863, 4724, 1829, 11622, 25708, 4032, 2423, 4967, 8980, 4724, 1829, 4587, 1211, 5296, 33456, 3224, 4724, 1829, 9381, 13546, 2423, 3677, 5551, 4117, 2655, 2288, 15844, 2423, 2107, 4364, 794, 4478, 6156, 3555, 11622, 25708, 25894, 11296, 2423, 8980, 39894, 11622, 25708, 2423, 8980, 5551, 15042, 2423, 4967, 8980, 6156, 3224, 2407, 4724, 1829, 4587, 1211], "avg_logprob": -0.4912500035762787, "compression_ratio": 1.7246376811594204, "no_speech_prob": 0.0, "words": [{"start": 401.64, "end": 402.46, "word": "الخطوة", "probability": 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than إذا كان صار بعد shortening من isometric contraction يعني العضلة يعني احنا خلينا نفترض ان ال biceps بتعمل affliction احنا بدنا نعمل affliction against resistance لمين لل biceps فاحنا", "tokens": [259, 264, 5512, 1341, 379, 37629, 1785, 813, 11933, 15730, 25961, 20328, 9640, 39182, 2099, 4559, 9154, 307, 29470, 37372, 37495, 22653, 18863, 11242, 37977, 37495, 22653, 1975, 5016, 8315, 16490, 20292, 8315, 8717, 5172, 2655, 43042, 16472, 2423, 272, 35552, 39894, 25957, 1211, 48287, 313, 1975, 5016, 8315, 47525, 8315, 8717, 25957, 1211, 48287, 313, 1970, 7335, 5296, 2304, 9957, 24976, 272, 35552, 6156, 39319, 8315], "avg_logprob": -0.2195542310090626, "compression_ratio": 1.5736842105263158, "no_speech_prob": 2.562999725341797e-06, "words": [{"start": 627.76, "end": 628.08, "word": "in", "probability": 0.3876953125}, {"start": 628.08, "end": 628.38, "word": " the", "probability": 0.79345703125}, {"start": 628.38, "end": 629.16, "word": " concentrically", "probability": 0.8466796875}, 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stretch techniques or by increasing the strength of the antagonist يعني يا إما أنا بشد العضلاء يا إما بأول عضلاء اللي على قبلها عشان أنا أقدر أزود ال elasticity تبعتها", "tokens": [1829, 3555, 4587, 7578, 46260, 393, 312, 9689, 538, 23223, 7335, 295, 27871, 1038, 66, 4524, 8679, 1228, 13437, 420, 8546, 5985, 7512, 420, 538, 5662, 264, 3800, 295, 264, 32590, 468, 37495, 22653, 35186, 11933, 15042, 41850, 4724, 8592, 3215, 18863, 11242, 1211, 16606, 35186, 11933, 15042, 4724, 10721, 12610, 6225, 11242, 1211, 16606, 13672, 1829, 15844, 12174, 36150, 11296, 6225, 8592, 7649, 41850, 5551, 28543, 2288, 5551, 11622, 23328, 2423, 46260, 6055, 3555, 34268, 11296], "avg_logprob": -0.16917066830090988, "compression_ratio": 1.5418502202643172, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2059.49, "end": 2060.01, "word": "يبقى", "probability": 0.928466796875}, {"start": 2060.01, "end": 2060.63, "word": " elasticity", "probability": 0.548828125}, {"start": 2060.63, "end": 2061.39, 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2076.23, "end": 2076.39, "word": " على", "probability": 0.7275390625}, {"start": 2076.39, "end": 2077.01, "word": " قبلها", "probability": 0.7197265625}, {"start": 2077.01, "end": 2077.71, "word": " عشان", "probability": 0.9791666666666666}, {"start": 2077.71, "end": 2077.93, "word": " أنا", "probability": 0.72412109375}, {"start": 2077.93, "end": 2078.49, "word": " أقدر", "probability": 0.98681640625}, {"start": 2078.49, "end": 2079.01, "word": " أزود", "probability": 0.94287109375}, {"start": 2079.01, "end": 2079.17, "word": " ال", "probability": 0.96435546875}, {"start": 2079.17, "end": 2079.71, "word": " elasticity", "probability": 0.8681640625}, {"start": 2079.71, "end": 2081.17, "word": " تبعتها", "probability": 0.97216796875}], "temperature": 1.0}, {"id": 95, "seek": 210010, "start": 2081.38, "end": 2100.1, "text": "as the muscle is viscoelastic، الـ elastic properity permits spring-like behavior اللي بيخلّي العضلة ترجع لل original link بعد ما تكون صار لها stretching، طبعا الviscosity أو الviscosity properity بتخلي حاجة اسمها plasticity", "tokens": [296, 264, 8679, 307, 1452, 1291, 338, 2750, 12399, 2423, 39184, 17115, 2296, 507, 30990, 5587, 12, 4092, 5223, 13672, 1829, 4724, 1829, 9778, 1211, 11703, 1829, 18863, 11242, 37977, 6055, 47341, 3615, 24976, 3380, 2113, 39182, 19446, 6055, 30544, 20328, 9640, 5296, 11296, 19632, 12399, 23032, 3555, 3615, 995, 2423, 4938, 6877, 507, 34051, 2423, 4938, 6877, 507, 2296, 507, 39894, 9778, 20292, 11331, 26108, 3660, 24525, 2304, 11296, 5900, 507], "avg_logprob": -0.2335188339834344, "compression_ratio": 1.4009661835748792, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 2081.38, "end": 2081.68, "word": "as", "probability": 0.4462890625}, {"start": 2081.68, "end": 2081.84, "word": " the", "probability": 0.8681640625}, {"start": 2081.84, "end": 2082.14, "word": " muscle", "probability": 0.95751953125}, {"start": 2082.14, "end": 2082.48, "word": " is", "probability": 0.94970703125}, {"start": 2082.48, 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b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/QJlRIqQmh3o.srt new file mode 100644 index 0000000000000000000000000000000000000000..f12d8d424b8ec6727adae33397cf2ae98f205749 --- /dev/null +++ b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/QJlRIqQmh3o.srt @@ -0,0 +1,1395 @@ +1 +00:00:00,000 --> 00:00:02,940 +بسم الله الرحمن الرحيم الصلاة والسلام علي سيدنا + +2 +00:00:02,940 --> 00:00:07,200 +محمد وعلي وصحبه أجمعين المحاضرة الثانية في موضوع + +3 +00:00:07,200 --> 00:00:11,260 +ال gait هنتكلم اليوم عن ال additional determinants + +4 +00:00:11,260 --> 00:00:14,220 +of gait إيش يعني determinants يعني محددات ال gait + +5 +00:00:14,220 --> 00:00:17,940 +طب نتكلمنا عن ال gait cycle في المحاضرة السابقة و + +6 +00:00:17,940 --> 00:00:22,260 +تكلمنا إن في عندنا two phases في عندنا ال swing + +7 +00:00:22,260 --> 00:00:26,760 +phase و في عندنا ال stance phase و .. وشرحنا كل + +8 +00:00:26,760 --> 00:00:30,420 +واحدة إيش ال .. ال .. الحركات اللي بت .. اللي + +9 +00:00:30,420 --> 00:00:34,060 +بتصير فيها و المراحل و إيش العضلات اللي بتكون + +10 +00:00:34,060 --> 00:00:37,200 +active و العضلات اللي بتكون active سواء concentric + +11 +00:00:37,200 --> 00:00:41,500 +أو eccentric دي كمان هنا هنتكلم عن أشياء مهمة عشان + +12 +00:00:41,500 --> 00:00:44,240 +يكون عندنا normal gait و عشان يكون في عندنا مظهر ال + +13 +00:00:44,240 --> 00:00:50,540 +gait زي اللي احنا المظهر اللي احنا متعودين عليه طبعا + +14 +00:00:50,540 --> 00:00:53,520 +احنا بنتكلم دائما في ال gait عن ال lower limb، + +15 +00:00:53,520 --> 00:00:56,800 +بنركز كتير على ال lower limb، إيش بيصير فيها، لكن + +16 +00:00:56,800 --> 00:01:01,460 +بالحقيقة إنه في عندنا other events بتصير معنا، في + +17 +00:01:01,460 --> 00:01:04,700 +ال .. في باقي الجسد، سواء كان في ال trunk، سواء + +18 +00:01:04,700 --> 00:01:08,320 +في ال upper limb، سواء كان في ال pelvis، شكل ال + +19 +00:01:08,320 --> 00:01:12,240 +step نفسها، طولها، البعد الرجلين عن بعضهم، هذه + +20 +00:01:12,240 --> 00:01:15,060 +كلها برضه محددات بتقولنا إنه هذا normal gait or + +21 +00:01:15,060 --> 00:01:18,460 +not normal gait، عشان هيحنا نتكلم عن المحددة هذه + +22 +00:01:18,460 --> 00:01:22,020 +تقريبا يعني احنا نتكلم عن ال vertical displacement + +23 +00:01:22,020 --> 00:01:25,200 +لل center of gravity و ال horizontal displacement و + +24 +00:01:25,200 --> 00:01:30,400 +حنتكلم عن ال width of walking path و عن ال lateral + +25 +00:01:30,400 --> 00:01:33,900 +pelvic tilt و ال step length و ال arm swing و + +26 +00:01:33,900 --> 00:01:37,460 +other factors زي ال head و ال trunk و كل الأمور + +27 +00:01:37,460 --> 00:01:42,380 +هذه كيف لازم يكون وضعيتها أثناء عملية المشي + +28 +00:01:45,840 --> 00:01:49,840 +طبعا أو تكلمنا عن ال center of gravity احنا + +29 +00:01:49,840 --> 00:01:52,080 +عارفين لو احنا بنمشي احنا وكأننا بنلحق ال center + +30 +00:01:52,080 --> 00:01:54,960 +of gravity عشان ما يصيرش falling يعني احنا كل ما + +31 +00:01:54,960 --> 00:01:59,900 +بنتقدم خطوة ال center of gravity بيصير فيه له تحرك + +32 +00:01:59,900 --> 00:02:03,140 +طب يعني نرجع مع بعض ال center of gravity بيمر في line + +33 +00:02:03,140 --> 00:02:08,880 +of gravity بيمر anterior to second sacral vertebra + +34 +00:02:09,190 --> 00:02:13,350 +طيب هلاقي إن احنا لو احنا ماشيين احنا عارفين ان ال + +35 +00:02:13,350 --> 00:02:18,370 +.. ال center of gravity بيطلع و بينزل بيكون طبعا + +36 +00:02:18,370 --> 00:02:22,750 +عالي مرتفع لما بنكون احنا في ال single leg support + +37 +00:02:22,750 --> 00:02:26,410 +أو هنقول في ال mid stance و بيكون واطي لما نكون في + +38 +00:02:26,410 --> 00:02:30,080 +ال double support طيب ليش هيك احنا لو احنا مثلنا + +39 +00:02:30,080 --> 00:02:34,260 +العملية هذه إذا كانوا احنا ماشيين نمسكنا قطعة من + +40 +00:02:34,260 --> 00:02:39,200 +التباشير وقاعدين بنمشي و بنحدد على ال blackboard + +41 +00:02:39,200 --> 00:02:45,860 +على اللي هو اللوح الأسود؟ وبنمشي طيب احنا لما بنمشي + +42 +00:02:45,860 --> 00:02:48,680 +و كأننا بنرسم زي ال path إيش ال path زي ال wave + +43 +00:02:48,680 --> 00:02:55,980 +like line هذا اللي احنا شايفينه بالمنظر هذا عبارة + +44 +00:02:55,980 --> 00:03:00,340 +عن الارتفاع و الانخفاض في ال center of gravity + +45 +00:03:00,340 --> 00:03:04,040 +بيرتفع و بينزل بيرتفع و بينزل دائما هذه بنسميها + +46 +00:03:04,040 --> 00:03:06,020 +احنا vertical displacement of + +47 +00:03:08,540 --> 00:03:13,600 +العامة العامة بتكون تقريبا اثنين انش يعني تقريبا + +48 +00:03:13,600 --> 00:03:18,820 +خمسة سنتي بتكون أعلى شيء في ال mid stance و + +49 +00:03:18,820 --> 00:03:23,980 +أوطى شيء في ال heel strike double support بنزل ال + +50 +00:03:23,980 --> 00:03:27,540 +center of gravity في ال mid stance بيرتفع يعني + +51 +00:03:27,540 --> 00:03:30,880 +احنا طول ما احنا ماشيين بنعمل عملية نقل لل center + +52 +00:03:30,880 --> 00:03:34,980 +of gravity على أساس إنه بيطلع و بينزل هذا لما + +53 +00:03:34,980 --> 00:03:37,600 +بيطلع فوق و بينزل لتحت احنا بنسميها vertical + +54 +00:03:37,600 --> 00:03:42,550 +displacement طب لما بنتقل من اليمين لليسار و من + +55 +00:03:42,550 --> 00:03:45,550 +اليسار لليمين هذه اسمه horizontal displacement + +56 +00:03:45,550 --> 00:03:48,390 +يعني ال center of gravity احنا عشان مش لازم نجيب + +57 +00:03:48,390 --> 00:03:52,710 +احنا لما بنقدم رجلنا اليمين اليمين بتبقى في ال + +58 +00:03:52,710 --> 00:03:55,690 +stance في أزمانها احنا بننقل وزننا كله على الرجل + +59 +00:03:55,690 --> 00:03:58,830 +اليمين بما فيه ال center of gravity هو بيروح ناحية + +60 +00:03:58,830 --> 00:04:01,670 +اليمين لما بنحط رجلنا لشمال بتبقى ال heel strike + +61 +00:04:01,670 --> 00:04:06,490 +تبع الرجل الشمال بنرجع فيه مرة ثانية على ال .. على + +62 +00:04:06,490 --> 00:04:09,680 +الرجل .. على الرجل الشمال فبيصير هذا horizontal + +63 +00:04:09,680 --> 00:04:12,640 +بنسميها horizontal displacement أو اللي هو التغير + +64 +00:04:12,640 --> 00:04:16,900 +الأفقي فيه أو الإزاحة الأفقية لل center of gravity + +65 +00:04:16,900 --> 00:04:20,120 +وهذا بلحق ال weight shifting من side ل side احنا + +66 +00:04:20,120 --> 00:04:22,160 +طول ما احنا بنمشي ال weight shift بيروح على اليمين + +67 +00:04:22,160 --> 00:04:24,700 +وبعدين برجع على اليسار على اليمين وعلى اليسار + +68 +00:04:24,700 --> 00:04:28,020 +طول ما احنا بنمشي طبعا this displacement بتكون + +69 +00:04:28,020 --> 00:04:31,480 +greatest during single support phase لإنه بيروح + +70 +00:04:31,480 --> 00:04:35,110 +أو في ال mid stance لإنه بيروح completely على ال + +71 +00:04:35,110 --> 00:04:39,070 +right side وبعدين بينتقل على ال left side مرة + +72 +00:04:39,070 --> 00:04:42,970 +ثانية in other words this represent the distance + +73 +00:04:42,970 --> 00:04:48,150 +the body must shift horizontally on to one foot so + +74 +00:04:48,150 --> 00:04:52,550 +that the other foot can swing forward طبعا احنا ال + +75 +00:04:52,550 --> 00:04:57,370 +mid stance هي أكثر شيء بيكون مركز ال center of + +76 +00:04:57,370 --> 00:05:00,590 +gravity مثلا افترضنا على الرجل اليمين فبتكون + +77 +00:05:00,590 --> 00:05:04,630 +الرجل الشمال بتعمل swinging يعني بتبدأ بتنتقل + +78 +00:05:04,630 --> 00:05:09,590 +لقدام أساس إننا نعمل الخطوة اللي بعدها this side و + +79 +00:05:09,590 --> 00:05:12,690 +this side displacement بتكون تقريبا اثنين inches + +80 +00:05:12,690 --> 00:05:17,910 +يعني حوالي خمسة سنتي كمان في عامل كتير مهم احنا + +81 +00:05:17,910 --> 00:05:22,270 +لما بنتكلم عن ال width of walking path احنا لو + +82 +00:05:22,270 --> 00:05:25,350 +مشينا عمرنا ما مشينا و رجلينا لازقين في بعض أكيد + +83 +00:05:25,350 --> 00:05:28,770 +دايما بنجري بعض عن بعض حتى يكون في عندنا توازن + +84 +00:05:28,770 --> 00:05:31,690 +يعني احنا لما بنمشي غير عرضات الأزياء هم اللي + +85 +00:05:31,690 --> 00:05:34,470 +بيمشوا بيكونوا عاملين رجليهم crossing لكن احنا + +86 +00:05:34,470 --> 00:05:37,650 +في المشي الطبيعي الناس العاديين بنمشي رجلينا + +87 +00:05:37,650 --> 00:05:41,630 +بيكونوا أبعد عن بعضهم يبقى when you walk you + +88 +00:05:41,630 --> 00:05:45,030 +do not place your feet one step in front of the + +89 +00:05:45,030 --> 00:05:48,050 +other but slightly apart يعني احنا مابنمشيش على + +90 +00:05:48,050 --> 00:05:51,750 +line احنا عادة لو كان في عندنا بلاطين فدائما رجلنا + +91 +00:05:51,750 --> 00:05:54,630 +بتكون الرجل اليمين في بلاطة والرجل الثاني الشمال + +92 +00:05:54,630 --> 00:05:58,730 +في البلاطة اللي جنبها يعني احنا مابنمشي على line + +93 +00:05:58,730 --> 00:06:03,270 +يعني كل مرة بنحط رجلنا على نفس ال line زي ما حكينا + +94 +00:06:03,270 --> 00:06:06,050 +عرضات الأزياء بس هم اللي بيكونوا رجليهم على ال + +95 +00:06:06,050 --> 00:06:09,330 +line وهذا هم بيعتبروه من الجمال ما بعرفش مع أنه + +96 +00:06:09,330 --> 00:06:14,130 +احنا يعني هذا بعيد عن ال normal gait if lines were + +97 +00:06:14,130 --> 00:06:17,030 +drawn through successive midpoints of the heel + +98 +00:06:17,030 --> 00:06:23,380 +contact of one foot بتكون المسافة ما بين ال two الـ + +99 +00:06:23,380 --> 00:06:28,240 +two feet بتكون تقريبا اثنين برضه لاربع inches يعني + +100 +00:06:28,240 --> 00:06:33,900 +من خمسة لثمانية من خمسة لثمانية سنتي تقريبا this is + +101 +00:06:33,900 --> 00:06:37,760 +described as ال width of walking path يعني احنا + +102 +00:06:37,760 --> 00:06:41,380 +كلنا لما بنمشي بيكون رجلينا متبعدين عن بعض تقريبا + +103 +00:06:41,380 --> 00:06:46,670 +من اثنين لاربع inches كمان في عندنا ال lateral + +104 +00:06:46,670 --> 00:06:52,690 +pelvic tilt هاي بتكون واضحة يعني احنا لما بنبقى + +105 +00:06:52,690 --> 00:06:56,150 +ماشيين بتحسوا إنه كأنه ال gluteus maximus بتطلع و + +106 +00:06:56,150 --> 00:06:59,910 +بتنزل و بتطلع و بتنزل طبعا slightly هذه لو كانت + +107 +00:06:59,910 --> 00:07:03,190 +زيادة عن اللزوم بتروح لحاجة اسمها Trendelenberg + +108 +00:07:03,190 --> 00:07:07,570 +sign و اللي بيصير هنا في ال lateral pelvic tilt + +109 +00:07:07,570 --> 00:07:14,670 +إنه و احنا ماشيين عادة لو حطينا إيدنا على ال hips + +110 +00:07:14,670 --> 00:07:18,770 +بنلاقي الإيد بتطلع و بتنزل يعني عادة we notice + +111 +00:07:18,770 --> 00:07:23,770 +that they move up and down as your pelvic on each + +112 +00:07:23,770 --> 00:07:27,650 +side drops down slightly يعني إحنا لو حطينا إيدنا + +113 +00:07:27,650 --> 00:07:30,950 +على خواصرنا أو على ال anterior superior iliac + +114 +00:07:30,950 --> 00:07:35,310 +spine ومشينا بنلاقي وإحنا ماشيين إيدنا + +115 +00:07:35,310 --> 00:07:37,750 +بتنزل و بتطلع و بتنزل و بتطلع + +116 +00:07:43,930 --> 00:07:48,530 +لما يكون ال weight bearing taking place of the leg at + +117 +00:07:48,530 --> 00:07:53,430 +the toes off طب هذا إيش اللي بيصير لو زاد ال + +118 +00:07:53,430 --> 00:07:58,570 +slight drop بيسموه Trendelenberg sign لكن هذه ال + +119 +00:07:58,570 --> 00:08:04,350 +limping هذا شيء متقدم أكثر نتيجة ال weakness ل ال + +120 +00:08:04,350 --> 00:08:08,670 +abductors of the hip طبعا هنا لو بنشوف الصورة هان + +121 +00:08:08,670 --> 00:08:13,110 +الصورة هان بتكون واضحة لنا احنا لما بنطلع هنا هنا + +122 +00:08:13,110 --> 00:08:17,710 +صارت الرجل اليسار هذه في ال mid swing وهذه في ال + +123 +00:08:17,710 --> 00:08:22,040 +mid stance وهذه في ال mid swing تمام؟ هلأ هنا إيش + +124 +00:08:22,040 --> 00:08:25,480 +اللي بيصير؟ اللي بيصير إنه إحنا ماشيين هان ال + +125 +00:08:25,480 --> 00:08:30,100 +hip adductors، hip abductors هذه لازم + +126 +00:08:30,100 --> 00:08:34,120 +تصير فيها contraction عشان هذا الـ hip يطلع فاللي + +127 +00:08:34,120 --> 00:08:39,020 +بيصير إنه هان بنزل شوية الـ بالفكو بتشتغل .. بتشتغل + +128 +00:08:39,020 --> 00:08:42,540 +هنا عشان هادي تمنع الـ drop هذا إنه يكون excessive + +129 +00:08:42,540 --> 00:08:46,260 +أو زيادة الـ adductors الـ hip .. الـ hip abductors + +130 +00:08:46,260 --> 00:08:50,140 +تبع الرجل مش المرفوع عن الأرض الرجل اللي موجود على + +131 +00:08:50,140 --> 00:08:54,140 +الأرض بتعمل contraction و الـ erector spinae بتعمل + +132 +00:08:54,140 --> 00:08:57,480 +contraction يعني إذا بتتذكر و لما كنا بنتكلم عن الـ + +133 +00:08:57,480 --> 00:09:02,390 +steering كيف بتصير في عندنا الـ couple of forces هدى + +134 +00:09:02,390 --> 00:09:05,330 +بالظبط هدى كانت مثل على الـ couple of forces زي ما + +135 +00:09:05,330 --> 00:09:09,450 +احنا مسكين الـ steering الـ hip abductors بدها تنزل + +136 +00:09:09,450 --> 00:09:14,010 +و الـ hip و الـ erector spinae بدها ترفع الـ pelvis + +137 +00:09:14,010 --> 00:09:18,150 +عشان مايصيرش عندنا excessive drop للـ pelvis يبقى + +138 +00:09:18,150 --> 00:09:23,960 +this dip would be greater if it is not or were not + +139 +00:09:23,960 --> 00:09:27,040 +for the hip abductor on the opposite side اللي هي + +140 +00:09:27,040 --> 00:09:30,680 +الـ weight bearing side اللي هي هذه and erector + +141 +00:09:30,680 --> 00:09:33,900 +spinae on the same side اللي هما هدول together + +142 +00:09:33,900 --> 00:09:39,120 +working to keep الـ pelvis essentially على الـ level + +143 +00:09:39,120 --> 00:09:42,600 +على نفس الـ side بيصير إنه small drop أو slight + +144 +00:09:42,600 --> 00:09:46,610 +drop في الـ pelvis when the bill fits drops on the + +145 +00:09:46,610 --> 00:09:50,230 +right side اللي هي non-weight bearing side الـ left + +146 +00:09:50,230 --> 00:09:52,950 +hip الـ weight bearing side is forced into + +147 +00:09:52,950 --> 00:09:56,810 +adduction هذه الحركة اللي هنا بتصير هي adoption + +148 +00:09:56,810 --> 00:10:01,650 +يعني احنا حركة الـ adoption عادة بيكون بالفك على هذا + +149 +00:10:01,650 --> 00:10:05,750 +الـ line و الإجر اللي بتيجي لهيك اللي بتيجي على + +150 +00:10:05,750 --> 00:10:09,950 +القريبة من الـ midline لكن لهذا لقيت الـ lower limb + +151 +00:10:09,950 --> 00:10:13,610 +أو left lower limb ثابتة و الـ pelvis هو اللي أجه فهي + +152 +00:10:13,610 --> 00:10:17,310 +هذه حركة adduction اللي بيمنعها اللي بيمنعها الـ + +153 +00:10:17,310 --> 00:10:20,490 +contraction للـ hip abductors اللي بتسحب بهذا + +154 +00:10:20,490 --> 00:10:24,170 +الاتجاه فبيطلع الـ pelvis لفوق + +155 +00:10:27,580 --> 00:10:30,380 +طبعا to keep the pelvic level although actually + +156 +00:10:30,380 --> 00:10:34,360 +dips slightly the left hip abductors contracts زي + +157 +00:10:34,360 --> 00:10:38,380 +ما حكينا to prevent the hip adduction at the same + +158 +00:10:38,380 --> 00:10:42,680 +time الـ right erector spinae ليها دي which has + +159 +00:10:42,680 --> 00:10:45,680 +attachment on the pelvic contract to pull up + +160 +00:10:45,680 --> 00:10:49,880 +تسحبها لفوق in the side of the pelvic that wants + +161 +00:10:49,880 --> 00:10:54,640 +to drop فبيكون الـ drop بس slight drop طبعا لو زاد + +162 +00:10:54,640 --> 00:11:00,790 +بيصير شيء أكثر خلينا نقول مرضى كمان في عندنا الـ + +163 +00:11:00,790 --> 00:11:03,910 +step length قولنا إنه مهما كان الـ cadence مهما + +164 +00:11:03,910 --> 00:11:07,430 +كانت سرعتنا في المشي الـ step length should be + +165 +00:11:07,430 --> 00:11:12,010 +equal in both distance and time لو قلت الـ time + +166 +00:11:12,010 --> 00:11:14,790 +فيصير في عندنا limping لو قلت الـ distance بنسميه + +167 +00:11:14,790 --> 00:11:18,010 +limping أو لما تكون عندنا sore leg لما تكون الرجل + +168 +00:11:18,010 --> 00:11:23,070 +موجوعة صار الـ step length عشان هيك؟ احنا نتكلم عن + +169 +00:11:23,070 --> 00:11:27,050 +الـ normal gait should be two steps equal الـ step + +170 +00:11:27,050 --> 00:11:31,270 +length should be equal in distance and in time في + +171 +00:11:31,270 --> 00:11:35,550 +كمان عندنا الـ رقم ستة من الـ determinants هي الـ arm + +172 +00:11:35,550 --> 00:11:39,930 +swinging احنا قلنا عادة احنا لما بنمشي أنتو طبعا + +173 +00:11:39,930 --> 00:11:42,730 +ال اتا بتمشي و مش دايرين بالكوا كتير من مشياتكوا + +174 +00:11:42,730 --> 00:11:46,710 +لكن لما بنمشي احنا عادة بنقدم الرجل اليمين مع + +175 +00:11:46,710 --> 00:11:51,250 +الـ ايد اليسار و لما نقدم الرجل اليسار بنقدم الـ ايد + +176 +00:11:51,250 --> 00:11:56,120 +اليف بالتالي في عندنا rotation للـ trunk احنا لما بيجي + +177 +00:11:56,120 --> 00:12:00,880 +في نهاية الـ swing و بدنا نزل رجلنا على الأرض في الـ + +178 +00:12:00,880 --> 00:12:04,780 +stance أو في الـ heel strike بيكون في عندنا كمان في + +179 +00:12:04,780 --> 00:12:09,150 +عندنا forward rotation للـ trunk فبتروح الـ arm اللي في + +180 +00:12:09,150 --> 00:12:13,050 +الناحية التانية متقدمة عشان تحت من هذا الـ rotation + +181 +00:12:13,050 --> 00:12:17,530 +و تعمل control على الـ rotation و تعملنا control + +182 +00:12:17,530 --> 00:12:21,290 +على الـ amount of rotation كأنها بتعمل a counter + +183 +00:12:21,290 --> 00:12:25,230 +rotation يعني احنا لما بنمشي بنقدم رجلنا مثلا + +184 +00:12:25,230 --> 00:12:30,250 +اليمين فبنلاقي الـ trunk بروح على الناحية اليسار + +185 +00:12:30,250 --> 00:12:36,500 +فبتروح ايدنا اليسار متقدمة عشان تعمله تحد من هذا الـ + +186 +00:12:36,500 --> 00:12:41,480 +rotation اللي صار و تعمله control كمان في عندنا + +187 +00:12:41,480 --> 00:12:45,580 +other determinants طبعا زي الـ head الـ head should + +188 +00:12:45,580 --> 00:12:48,840 +be erect الـ shoulder should be لازم يكون رأسنا و + +189 +00:12:48,840 --> 00:12:53,520 +احنا ماشيين رأسنا مرفوعة كمان الـ shoulder level + +190 +00:12:53,520 --> 00:12:57,740 +برضه لازم يكونوا اتنين على نفس المستقيم و الـ trunk + +191 +00:12:57,740 --> 00:13:01,490 +in extension عادة احنا بنلاحظ كتير من الصبايا اللي + +192 +00:13:01,490 --> 00:13:05,530 +بيحملوا شنطهم على كتف واحد و يكونوا متعودين فدائما + +193 +00:13:05,530 --> 00:13:10,170 +بتلاقيهم الكتف اللي عليه الشنطة و كأنه مرفوع أعلى + +194 +00:13:10,170 --> 00:13:14,390 +من الكتف الثاني طبعا لازم الكتفان يكونوا على نفس + +195 +00:13:14,390 --> 00:13:18,670 +المستوى و كمان الـ trunk يكون erect in extension + +196 +00:13:19,370 --> 00:13:23,150 +طبعا احنا when we analyzing someone's gait it is + +197 +00:13:23,150 --> 00:13:27,210 +best to view الـ person from both side and in the + +198 +00:13:27,210 --> 00:13:30,990 +front and sometime in the back احنا درسنا مع بعض + +199 +00:13:30,990 --> 00:13:35,830 +إذا بتتذكروا صماية مادة الـ introduction وعملنا + +200 +00:13:35,830 --> 00:13:40,210 +فيها كيف احنا بنتطلع على الشخص من الـ anterior view + +201 +00:13:40,210 --> 00:13:43,010 +من الـ lateral view و إيش بنشوف في الـ anterior و + +202 +00:13:43,010 --> 00:13:47,970 +إيش بنشوف في الـ lateral view طبعا لو بدنا نتكلم + +203 +00:13:47,970 --> 00:13:52,470 +بدنا نشوف الـ step length ولا الـ arm swinging ولا + +204 +00:13:52,470 --> 00:13:56,630 +الـ head position ولا الـ trunk ولا الـ activity of + +205 +00:13:56,630 --> 00:14:00,830 +the lower leg عادة بنشوفها من الـ side position أما + +206 +00:14:00,830 --> 00:14:05,170 +إذا بدنا نشوف الـ position of the shoulder الـ head + +207 +00:14:05,170 --> 00:14:10,480 +بنشوفه من الـ front or back يعني احنا لازم نطلع على + +208 +00:14:10,480 --> 00:14:14,620 +شخص هو بمشي إذا بدنا نقيمه بنكون بنلف حوالينه عشان + +209 +00:14:14,620 --> 00:14:17,220 +نشوفه من lateral view من anterior view من + +210 +00:14:17,220 --> 00:14:21,220 +posterior view عشان إنه احنا نحدد إذا كان يعني بال + +211 +00:14:21,220 --> 00:14:24,380 +.. بال .. بال lateral view بنقدر نشوف الـ step + +212 +00:14:24,380 --> 00:14:27,420 +length و الـ arm swing و الـ position of the head + +213 +00:14:27,420 --> 00:14:31,400 +and trunk أما من الـ anterior view فبنشوف الـ + +214 +00:14:31,400 --> 00:14:36,820 +shoulder إذا كانوا اتنين على نفس الـ level أو لأ طيب + +215 +00:14:36,820 --> 00:14:41,920 +نروح لـ .. الـ .. الـ age related gate pattern طيب + +216 +00:14:41,920 --> 00:14:46,940 +صحيح إنه في عندنا الـ .. يعني مش كل deviation بيصير + +217 +00:14:46,940 --> 00:14:51,000 +أو مش كل مشكلة بنشوفها بنقولها والله هذا الشخص + +218 +00:14:51,000 --> 00:14:54,960 +عنده مشكلة لأن عادة الـ .. الـ daily ولد children + +219 +00:14:54,960 --> 00:14:58,300 +نشياتهم شوية بتختلف هي بتكون within normal pattern + +220 +00:14:58,300 --> 00:15:02,660 +لكن هي نشياتهم بتختلف عن الـ adult أو الـ younger .. + +221 +00:15:02,660 --> 00:15:07,020 +إيه adult؟ يبقى مش كل مشكلة مش كل gait pattern + +222 +00:15:07,020 --> 00:15:10,560 +مابتنطبخش على اللي احنا اتعلمناها ده فهي بتكون + +223 +00:15:10,560 --> 00:15:15,320 +abnormal هي عادة بتكون normal لكن و هي مش + +224 +00:15:15,320 --> 00:15:19,360 +pathological لأن احنا الأطفال و الكبار السن اللي + +225 +00:15:19,360 --> 00:15:23,880 +هم يعني خليني نقول characteristics مختلفة شوية عن + +226 +00:15:23,880 --> 00:15:27,340 +الـ younger adult لأن هدول الأطفال طبعا بيكونوا + +227 +00:15:27,340 --> 00:15:30,980 +لسه أول ماشيهم و مش متوازنين و الكبار بالسن بيكون + +228 +00:15:30,980 --> 00:15:35,510 +خليني نقول آخر ماشيهم و مش متوازنين فبالتالي يعني + +229 +00:15:35,510 --> 00:15:39,710 +بيكون لهم حركات شوية مختلفة عن الـ normal gait + +230 +00:15:39,710 --> 00:15:43,070 +اللي هي it is not pathological هي بس aging related + +231 +00:15:43,070 --> 00:15:48,430 +أو بيسموها age relating gait pattern طبعا these are + +232 +00:15:48,430 --> 00:15:52,090 +considered age related not pathological changes + +233 +00:15:52,090 --> 00:15:56,210 +these differences في الـ young children و بتبدأ يصير + +234 +00:15:56,210 --> 00:16:00,430 +لها disappeared كل ما بيصيروا أكبر و بعدين بترجع + +235 +00:16:00,540 --> 00:16:04,080 +مرة تانية أحيانا يعني في طبعا بيصير characteristic + +236 +00:16:04,080 --> 00:16:12,060 +تانية مع الـ elder عادة الأطفال بيمشوا tend to walk + +237 +00:16:12,060 --> 00:16:15,780 +with wider walking base يعني بيكون الـ base الـ + +238 +00:16:15,780 --> 00:16:18,340 +support أو الـ big الـ walking base اللي اتكلمنا + +239 +00:16:18,340 --> 00:16:21,720 +عنها قلنا 2 ل 4 inches في الـ normal في الـ normal + +240 +00:16:21,720 --> 00:16:26,020 +adult فتكون أكبر شوية الـ cadence faster بتلاحظوا + +241 +00:16:26,020 --> 00:16:29,220 +أن الأطفال بيمشوا بسرعة بسرعة بسرعة أول ما بيبدوا + +242 +00:16:29,220 --> 00:16:32,580 +يتحركوا يمشوا بيمشوا لأنه احنا قلنا بتوازنوا أكثر و + +243 +00:16:32,580 --> 00:16:36,860 +هم سريعين و كمان الـ stride length بتكون أقصر لأن + +244 +00:16:36,860 --> 00:16:41,280 +طبيعة إجرهم أقصر هم و كمان هم يعني بيعملوا خطوات + +245 +00:16:41,280 --> 00:16:46,240 +أكثر من الـ .. الـ .. الـ adult أو الـ .. الـ .. الـ + +246 +00:16:46,240 --> 00:16:50,870 +young adult كمان أول ما بيحطوا أجرهم الـ initial + +247 +00:16:50,870 --> 00:16:53,570 +contact with the floor الـ normal عادي الـ adult + +248 +00:16:53,570 --> 00:16:57,070 +بيحطها بالـ heel بنسميها الـ heel strike بينما + +249 +00:16:57,070 --> 00:17:01,050 +الأطفال لأ بيحطوا الـ foot flat بيحطوا رجلهم على + +250 +00:17:01,050 --> 00:17:06,440 +الأرض كلها طب عادة يعني أما احنا الكبار العاديين + +251 +00:17:06,440 --> 00:17:10,660 +أبناء بنحط ال heel وبعدين بنحط الـ .. بنعمل يعني + +252 +00:17:10,660 --> 00:17:13,960 +heel strike وبعدين foot flat وبعدين mid stance + +253 +00:17:13,960 --> 00:17:17,260 +أما هدول الأطفال بيكونوا صغار فبتلاقي رجلهم بتطب + +254 +00:17:17,260 --> 00:17:21,660 +على الأرض طب كاملة ما بيعملوا heel strike طبعا الـ + +255 +00:17:21,660 --> 00:17:24,820 +people دائما بتكون extended during stand phase على + +256 +00:17:24,820 --> 00:17:27,860 +طول في عندهم knee extension ومعظم الأطفال كمان + +257 +00:17:27,860 --> 00:17:32,890 +بتكون عندهم high bar extension in other words هدولة + +258 +00:17:32,890 --> 00:17:37,630 +الأطفال more steps.. take more steps than.. that + +259 +00:17:37,630 --> 00:17:40,970 +دائما بتكون shorter و choppy ومتقطعة يعني بتكون + +260 +00:17:40,970 --> 00:17:46,390 +قصيرة ومتقطعة وfaster period يعني.. يعني.. + +261 +00:17:46,390 --> 00:17:50,330 +يعني هم مشيتهم بتكون كثير سريعة وكأنهم بنط ونط + +262 +00:17:50,330 --> 00:17:54,690 +يعني فعادة الأطفال هدول عشان هم بيكونوا مش + +263 +00:17:54,690 --> 00:17:58,330 +متوازنين فبفضلوا أنهم يمشوا بسرعة بسرعة بسرعة عسى + +264 +00:17:58,330 --> 00:18:03,770 +أنهم ما يوقعوش وبعدين بعد فترة بيبقى ينطزم ماشيهم + +265 +00:18:03,770 --> 00:18:08,150 +وبصير أبطأ شوية they also have little or no + +266 +00:18:08,150 --> 00:18:11,330 +reciprocal arm swings طبعا هذا بيكون واضح لما يبقى + +267 +00:18:11,330 --> 00:18:16,130 +واحد كبير ماشي مع ولد صغير يعني عادة يعني يدوب + +268 +00:18:16,130 --> 00:18:19,570 +بيحركوا أيديهم وهم ماشيين أو ما بيحركوهاش يعني + +269 +00:18:19,570 --> 00:18:22,350 +ما فيش الـ arm swing يعني الرجل اليمين مع الإيد + +270 +00:18:22,350 --> 00:18:25,430 +الشمال والرجل الشمال مع الإيد اليمين في الأطفال + +271 +00:18:25,430 --> 00:18:30,030 +هذه ما بنشوفها احنا كثير وزي ما قلنا هادي بتبين لما + +272 +00:18:30,030 --> 00:18:32,770 +يكون ولد صغير ماشي مع حد كبير + +273 +00:18:38,360 --> 00:18:41,680 +حتى لو ما كانش في عندنا even in the absence of + +274 +00:18:41,680 --> 00:18:44,540 +pathology كمان الـ elderly adults working better + +275 +00:18:44,540 --> 00:18:49,160 +undergoes changes طبعا الكبار بالسن حتى لو ما كانش + +276 +00:18:49,160 --> 00:18:52,240 +عندهم قصور لو ما كانش عندهم مشاكل لو ما كانش عندهم ألم + +277 +00:18:52,240 --> 00:18:56,900 +بتلاقي الـ الـ gait تبعتهم شوية بتختلف عن الـ + +278 +00:18:56,900 --> 00:19:03,110 +younger adults طيب عادة there is no universal + +279 +00:19:03,110 --> 00:19:06,030 +agreement on the reason of these exchanges it's + +280 +00:19:06,030 --> 00:19:09,890 +generally felt that sick purity and fear of + +281 +00:19:09,890 --> 00:19:13,410 +falling are the major contributors يعني ما حد فسر + +282 +00:19:13,410 --> 00:19:18,250 +ليش هذه التغيرات بتصير عند كبار السن بس الأكثر أن + +283 +00:19:18,250 --> 00:19:22,670 +هم لما تتغير الـ pattern تبع الـ movement أو الجهات + +284 +00:19:22,950 --> 00:19:26,950 +عندهم بيكونوا يعني حتى يحافظوا على الأمان تبعهم و + +285 +00:19:26,950 --> 00:19:30,510 +حتى يمنعوا سقوطهم لأن هم بيبقوا ماشيين وكأنهم + +286 +00:19:30,510 --> 00:19:33,810 +مثبتين في الأرض يعني هم ما بيكونوا بدهم يمشوا + +287 +00:19:33,810 --> 00:19:37,910 +بسرعة عشان ما يتعثرون فبالتالي هو بيتغير في.. + +288 +00:19:37,910 --> 00:19:42,950 +يعني بتضطر إنه يغير في..ال..الـ gait تبعتهم وعادة + +289 +00:19:42,950 --> 00:19:47,010 +typically الـ older adult lose muscle mass and less + +290 +00:19:47,010 --> 00:19:50,550 +activity and often have poorer hearing and vision + +291 +00:19:50,550 --> 00:19:54,410 +كل هذه العوامل يعني هو الكبير بالسن قلنا بيتراجع + +292 +00:19:54,410 --> 00:19:59,090 +في كل الأجهزة تبعته بما فيها كتلة العضلات بما فيها + +293 +00:19:59,090 --> 00:20:03,820 +حركة الجهاز الحركي بما فيها المشاكل السمعية والمشاكل + +294 +00:20:03,820 --> 00:20:07,900 +البصرية فهذه بتخليه طبعا عادة يعني محتاج إنه لأمان + +295 +00:20:07,900 --> 00:20:11,320 +كبير يعني شعور بالأمان إنه لما يمشي يبقى دائما + +296 +00:20:11,320 --> 00:20:16,360 +خائف من السقوط يعني عادة it should be recognized + +297 +00:20:16,360 --> 00:20:19,760 +that the effect of age are related to many factors + +298 +00:20:19,760 --> 00:20:23,040 +زي الـ health والـ activity level والـ attitude + +299 +00:20:23,040 --> 00:20:26,660 +عادة يعني في ناس بيكونوا كبار بالسن لكن ما شاء + +300 +00:20:26,660 --> 00:20:31,120 +الله مشيتهم بتبقى سريعة ودائريهم ناحية اليمين وما فيش + +301 +00:20:31,120 --> 00:20:35,700 +عندهم lucky forces ولا.. ولا إشي و.. وبيكونوا + +302 +00:20:35,700 --> 00:20:40,680 +يعني خلنا نقول مشيتهم مستصحى وحسب الـ level of + +303 +00:20:40,680 --> 00:20:44,320 +activity تبع هدول الناس حسب نفسياتهم حسب الصحة + +304 +00:20:44,320 --> 00:20:47,740 +العامة تبعتهم إذا ما عندهمش أمراض ولا + +305 +00:20:47,740 --> 00:20:51,400 +مشاكل إذا كانوا لسه active في مجتمعاتهم يعني في + +306 +00:20:51,400 --> 00:20:54,960 +كثير ناس بنشوفهم يعني عمرهم سبعين سنة يعني بتطلع + +307 +00:20:54,960 --> 00:20:58,200 +فيهم بتفكريه في الست.. بتفكروه في الستينات وفي ناس + +308 +00:20:58,200 --> 00:21:02,800 +بيكون عمره سبعين سنة بتفكريه عمره مية سنة لأن كيف + +309 +00:21:02,800 --> 00:21:06,700 +يعني حسب هو إيش نظرته لنفسه حسب هو إيش دوره اللي + +310 +00:21:06,700 --> 00:21:11,080 +بيقوم فيه في المجتمع حسب قداش هو نفسيا مرتاح ولا + +311 +00:21:11,080 --> 00:21:15,170 +مش مرتاح هل بيمارس activity بيمارس عمل معين بي.. + +312 +00:21:15,170 --> 00:21:19,830 +بيسلي بيضيع في وقته وكمان طبعا قلنا الحركة كثير + +313 +00:21:19,830 --> 00:21:23,350 +مفيدة في ناس متعودين إنهم يمشوا يعملوا exercise + +314 +00:21:23,350 --> 00:21:27,110 +ماشية في ناس بيعملوا تمارين رياضية وهكذا يعني + +315 +00:21:27,110 --> 00:21:30,890 +خلينا نقول إن الأشخاص لما بيكبروا بالسن مش كلهم + +316 +00:21:30,890 --> 00:21:36,130 +بياخدوا الـ typical نفس الـ gait عادة يعني الـ elderly + +317 +00:21:36,130 --> 00:21:41,830 +بتكون الـ walking تبعهم slower طبعا أبطأ بيقضوا + +318 +00:21:41,830 --> 00:21:45,050 +فترة كثير في الـ stance phase ليش؟ لأن هم بيشعروا + +319 +00:21:45,050 --> 00:21:47,410 +فيها في الأمان الـ stance phase يعني في عندنا + +320 +00:21:47,410 --> 00:21:51,130 +contact وبعدين فترة كبيرة في الـ double support إن + +321 +00:21:51,130 --> 00:21:54,950 +الرجلين يكونوا على الأرض لأن هو بيشعر بالأمان و + +322 +00:21:54,950 --> 00:21:58,930 +هو عنده قاعدة قوية من الـ two limbs تبعونه أكثر من + +323 +00:21:58,930 --> 00:22:02,100 +أن هو بيمشي على الـ single support يعني احنا في.. + +324 +00:22:02,100 --> 00:22:05,020 +في..في..في فترة من الفترات العمرو اللي هو اللي + +325 +00:22:05,020 --> 00:22:08,360 +الشباب الكثير وكأنه الشباب ما بيمشوش على الأرض + +326 +00:22:08,360 --> 00:22:11,260 +بتحسهم دائما طايرين بيجروا بيجروا بيجروا بيجروا يعني + +327 +00:22:11,260 --> 00:22:14,060 +فترة الـ non-support هذه بتكون موجودة عندهم ولما + +328 +00:22:14,060 --> 00:22:17,260 +بيكبر تصير لا تتحول تصير الـ double support هي اللي + +329 +00:22:17,260 --> 00:22:22,160 +بتشعر الشخص بالأمان أكثر بياخدوا شورته رسب طبعا + +330 +00:22:22,160 --> 00:22:26,870 +عشان ما يوقعوش vertical displacement بتقل لأن هم + +331 +00:22:26,870 --> 00:22:30,550 +بيقضوا فترة أطول في الـ double support عشان هي كده + +332 +00:22:30,550 --> 00:22:35,010 +بنزل الـ center of gravity walk with wider base + +333 +00:22:35,010 --> 00:22:38,730 +بيوسعوا الـ base of support and have greater + +334 +00:22:38,730 --> 00:22:41,630 +horizontal displacement لما ليش؟ لأنه في أنا wider + +335 +00:22:41,630 --> 00:22:44,750 +base فبالتالي الـ displacement بتزيد الـ horizontal + +336 +00:22:44,750 --> 00:22:49,570 +displacement of center of gravity بتزيد they are + +337 +00:22:49,570 --> 00:22:55,150 +fewer or slower automatic movement which may be + +338 +00:22:55,150 --> 00:22:59,450 +another factor increasing the chance of stumbling + +339 +00:22:59,450 --> 00:23:04,650 +or falling طبعا يعني الـ automatic movement بتقل كل + +340 +00:23:04,650 --> 00:23:08,990 +الجهاز العصبي تبع كبار السن بيختلف بيصير أبطأ + +341 +00:23:08,990 --> 00:23:13,780 +الاستجابات وسيالان العصبي بيصير أبطأ فبالتالي اللي + +342 +00:23:13,780 --> 00:23:16,780 +بيكونوا عرضة لأنهم يتعثرون كثير، إنهم يوقعوا + +343 +00:23:16,780 --> 00:23:22,840 +كثير، ردات فعلهم طبعا بتكون بطيئة للأشياء اللي.. + +344 +00:23:22,840 --> 00:23:28,040 +يعني للأشياء اللي ممكن يتعرضوا لها أثناء المشي In + +345 +00:23:28,040 --> 00:23:31,440 +turn, this may contribute to decrease to floor + +346 +00:23:31,440 --> 00:23:34,760 +clearance بيحاولوا إنهم ما يرفعوا رجلهم كثير عن + +347 +00:23:34,760 --> 00:23:42,670 +الأرض حتى ما يوقعوا خلينا ننهي محاضرتنا هذه لأن عشان + +348 +00:23:42,670 --> 00:23:46,310 +نبدأ في محاضرة ثانية هنتكلم فيها عن الـ abnormal + +349 +00:23:46,310 --> 00:23:48,150 +gait إن شاء الله diff --git a/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/QQ96c9MFL-g_raw.srt b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/QQ96c9MFL-g_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..6e832e18ed140af4e5baa91f2a0e9e89d334ab37 --- /dev/null +++ b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/QQ96c9MFL-g_raw.srt @@ -0,0 +1,1044 @@ +1 +00:00:00,590 --> 00:00:02,850 +بسم الله الرحمن الرحيم والصلاة والسلام على سيدنا + +2 +00:00:02,850 --> 00:00:07,750 +محمد سيد المرسلين وعلى أليه وصحبيه أجمعين محاضرتنا + +3 +00:00:07,750 --> 00:00:12,890 +اليوم السابعة في مساقى ال bio mechanics and + +4 +00:00:12,890 --> 00:00:17,590 +kinesiology هنتكلم فيها عن ال bio mechanics of + +5 +00:00:17,590 --> 00:00:19,930 +tendon and ligament + +6 +00:00:22,970 --> 00:00:27,530 +طبعا ال tendon وال ligament هي من ال connective + +7 +00:00:27,530 --> 00:00:35,130 +tissues في الجسم اللى بتعمل على ربط ال bones ب .. + +8 +00:00:35,130 --> 00:00:38,370 +يا اما two bones في بعض في ال joints اللى زى ال + +9 +00:00:38,370 --> 00:00:43,650 +ligamentأو ال .. ال bone with the muscle زي ال + +10 +00:00:43,650 --> 00:00:47,930 +tendon طبعا هم لهم تقريبا نفس الخواص بس بتختلف في + +11 +00:00:47,930 --> 00:00:51,590 +كميات ال .. ال collagen و ال .. و ال elastin لكن + +12 +00:00:51,590 --> 00:00:56,430 +هم بيحملوا نفس الخواص و هم نوع من أنواع ال dense + +13 +00:00:56,430 --> 00:01:03,090 +connective tissue طبعا التنين موجودين around the + +14 +00:01:03,090 --> 00:01:06,850 +joints of the bodyسواء كان ال ligament or tendon + +15 +00:01:06,850 --> 00:01:11,130 +لأنه لازم ال ligament هو عبارة عن الأربطة أما ال + +16 +00:01:11,130 --> 00:01:15,530 +tendons هي الأوتار و كلهم بيمروا من خلال المفاصل + +17 +00:01:15,530 --> 00:01:19,810 +لأنهالـ ligaments هي وظيفتها أنها تربط العظام مع + +18 +00:01:19,810 --> 00:01:26,310 +بعضها في العظام المفصل الواحد وأما ال tendons فهي + +19 +00:01:26,310 --> 00:01:30,710 +اللي بدها تقوم بالحركة بحركة هذه المفاصل عن طريق + +20 +00:01:30,710 --> 00:01:38,230 +الشد اللي بتعمله على ال bone يبقى both located in + +21 +00:01:38,230 --> 00:01:41,410 +and around the joints of the body and as a result + +22 +00:01:41,410 --> 00:01:45,730 +they both subjected to largedistractive or tensile + +23 +00:01:45,730 --> 00:01:50,450 +loads لأنه عمليات الشد اللي بتكون حاصلة على ال .. + +24 +00:01:50,450 --> 00:01:55,430 +التنين سواء دروس المفصل أو خارج المفصل عشان يقوم + +25 +00:01:55,430 --> 00:02:00,330 +المفصل بالحركات these are the structures that are + +26 +00:02:00,330 --> 00:02:04,370 +largely responsiblefor providing joint stability + +27 +00:02:04,370 --> 00:02:07,570 +during movement and function طبعا ال joint + +28 +00:02:07,570 --> 00:02:12,030 +stability هذه اشي كتير fundamental حتى الحركة تكون + +29 +00:02:12,030 --> 00:02:16,550 +طبيعية و فيها سلاسة و فيها smoothness عساس ان احنا + +30 +00:02:16,550 --> 00:02:21,630 +لما بتحرك المفصل بيصير عملية الشد من ال ligament + +31 +00:02:22,020 --> 00:02:26,780 +بتصير في ال muscles بتنتقل من ال muscle بالي لال + +32 +00:02:26,780 --> 00:02:33,500 +tendon ال tendon بيكون مشبوك بال bone فبصير الحركة + +33 +00:02:33,500 --> 00:02:37,180 +ال tendon and ligaments are biologically active + +34 +00:02:37,180 --> 00:02:40,590 +structuresمش يعني biological active structure انهم + +35 +00:02:40,590 --> 00:02:47,270 +عندهم قدرة على ال generation يبقى هي عادة بتكون + +36 +00:02:47,270 --> 00:02:53,650 +معرضة لل injury لل aging لأي abnormal position زي + +37 +00:02:53,650 --> 00:02:57,350 +مثلا ال immobilization فبصير في alteration في ال + +38 +00:02:57,350 --> 00:03:02,070 +composition and structureبتقل أو باتزيد الخواصة + +39 +00:03:02,070 --> 00:03:05,130 +بعتمد طبعا هو الكل دايما عارفين انه احنا ال + +40 +00:03:05,130 --> 00:03:08,470 +biological active structure هادي بيصير فيها عملية + +41 +00:03:08,470 --> 00:03:12,450 +ال regeneration طبعا إعادة البناء أو بيصير فيها + +42 +00:03:12,450 --> 00:03:18,890 +طبعا عملية الهدم أيضا these + +43 +00:03:18,890 --> 00:03:22,630 +changes in الشاشة affect mechanical improperities + +44 +00:03:22,630 --> 00:03:25,820 +ofthe tendon and ligament and as well the + +45 +00:03:25,820 --> 00:03:31,460 +functioning of the joints they are associated طبعا + +46 +00:03:31,460 --> 00:03:36,000 +زي ما احنا شايفين الصورة الموضحة هذا مفصل ال knee + +47 +00:03:36,000 --> 00:03:44,560 +مفصل + +48 +00:03:44,560 --> 00:03:51,700 +ال knee زي ما احنا شايفينه فلقيتها شايفين كهنا في + +49 +00:03:51,700 --> 00:03:56,890 +عندنا ال tendonاللي مشبوك بال بتلة اللي هو tendon + +50 +00:03:56,890 --> 00:04:00,990 +of the quadriceps او tendon بتلائي وهي في عندنا + +51 +00:04:00,990 --> 00:04:04,350 +هذا ال cartilage وفي عندنا ال ligament هذه ال + +52 +00:04:04,350 --> 00:04:11,010 +lateral collateral اللي بتربط الفيمر مع ال ال + +53 +00:04:11,010 --> 00:04:16,830 +tibia and also في عندنا هذا ال media ال collateral + +54 +00:04:16,830 --> 00:04:21,790 +لجامد و lateral collateral اللي بتربط الفيمر مع + +55 +00:04:21,790 --> 00:04:22,870 +الفيبولا + +56 +00:04:25,020 --> 00:04:32,220 +هذه التغييرات في الأسلحة تأثير على أسلحة التنضج + +57 +00:04:32,220 --> 00:04:38,420 +والتنضج ستكون مفروضة من مجلس التنضج والتنضج هنا + +58 +00:04:38,420 --> 00:04:45,860 +المهم للطبال الذين يتعاملون بالطب مع تنضج وتنضج + +59 +00:04:45,860 --> 00:04:49,980 +والتنضج والتنضج هي التعرف على هذه التغييرات + +60 +00:04:49,980 --> 00:04:51,360 +التسلسلية وميكانيكالية + +61 +00:04:53,790 --> 00:04:57,490 +saw that treatments selected will stimulate + +62 +00:04:57,490 --> 00:05:02,110 +positive tissue adaptation and improve joint and + +63 +00:05:02,110 --> 00:05:06,890 +overall function هذا الكلام يعني انه كاحنا ك + +64 +00:05:06,890 --> 00:05:12,990 +clinicians كفيزيو تيرابيس او دكتور او يعني اي حد + +65 +00:05:12,990 --> 00:05:18,510 +بيشتغل في مجال ال movement لازم يكون في عنده معرفة + +66 +00:05:18,510 --> 00:05:21,750 +حقيقية في ال mechanical properties تبع ال tendon + +67 +00:05:21,750 --> 00:05:26,360 +and ligamentهو كل ال interventions اللي بتعملها + +68 +00:05:26,360 --> 00:05:30,640 +سواء كانت ال exercise بيكون هدفها انها تحسن ال + +69 +00:05:30,640 --> 00:05:35,600 +movement و احنا عارفين انه اي limitation في ال .. + +70 +00:05:35,600 --> 00:05:39,000 +او contracture في ال tendon او الليجامنت هتعمل + +71 +00:05:39,000 --> 00:05:44,040 +انها limitation في ال movement طبعا ال structure + +72 +00:05:44,040 --> 00:05:47,720 +of the connective tissue ال tendon and ligament + +73 +00:05:47,720 --> 00:05:52,440 +compose of the connective tissue و طبعا هيمن أنواع + +74 +00:05:52,440 --> 00:05:57,020 +الـ connective tissue of the body وظيفتها انها ت + +75 +00:05:57,020 --> 00:06:02,080 +provide and maintain شكل ال body طبعا عارفين هي + +76 +00:06:02,080 --> 00:06:06,540 +supportive طبعا ال tissue و بتعمل و بتكون ال + +77 +00:06:06,540 --> 00:06:10,180 +function تبعتها mechanical بتعمل connection and + +78 +00:06:10,180 --> 00:06:15,320 +bind لسل و organs together و بتعطيني support ل ال + +79 +00:06:15,320 --> 00:06:18,260 +body يعني هي كمان بتعطي protection و بتعطي support + +80 +00:06:18,260 --> 00:06:22,910 +و بتعطي bonding كمان لالتي تجمع جميع عضلاتنا + +81 +00:06:22,910 --> 00:06:25,570 +وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا + +82 +00:06:25,570 --> 00:06:29,210 +وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا + +83 +00:06:29,210 --> 00:06:31,390 +وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا + +84 +00:06:31,390 --> 00:06:33,310 +وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا + +85 +00:06:33,310 --> 00:06:39,330 +وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا وعضلاتنا + +86 +00:06:39,330 --> 00:06:44,650 +وعضلاتنا وعضلاتنا وعضلاتنا + +87 +00:06:48,730 --> 00:06:52,270 +الـ connective tissue proper لمنها الـ loose and + +88 +00:06:52,270 --> 00:06:58,270 +dense connective tissue طبعا الـ loose connective + +89 +00:06:58,270 --> 00:07:01,050 +tissue بنلاقيها وان موجودة في ال muscle sheets + +90 +00:07:01,050 --> 00:07:05,930 +لأنه احنا عارفين ان العضلة محاطة بالأغشية زي + +91 +00:07:05,930 --> 00:07:08,370 +الابيميزيوم و البريميزيوم و الاندوميزيوم + +92 +00:07:08,370 --> 00:07:13,090 +supporting ال epithelial tissue and encircle neuro + +93 +00:07:13,500 --> 00:07:17,580 +vascular bundles في طبعا في ان انتوا عارفين ان + +94 +00:07:17,580 --> 00:07:24,220 +العضلات بيبت .. يعني بتيجي لها ال nutrition عن + +95 +00:07:24,220 --> 00:07:27,760 +طريق ال vascularization وكمان بيجي ال nervous + +96 +00:07:27,760 --> 00:07:30,340 +system في connection مع ال nervous system فهذه + +97 +00:07:30,340 --> 00:07:35,520 +بتبقى عملية ال tube اللي بتيجي بتمر من خلالها ال + +98 +00:07:35,520 --> 00:07:41,280 +bundles of ال vascularization and nervous system + +99 +00:07:42,530 --> 00:07:46,990 +Lose connective tissue is very delicate and not + +100 +00:07:46,990 --> 00:07:51,630 +very resistant to stress and strain or strain لأن + +101 +00:07:51,630 --> 00:07:57,630 +هي loose فكمية ال fibers و ال cells فيها قليلة و + +102 +00:07:57,630 --> 00:08:02,090 +كمية ال matrix بتكون فيها كتيرة ليش بتكون خفيفة + +103 +00:08:02,090 --> 00:08:07,010 +يعني هي كده عاملة زي الجيلاتين بدنا نفهم شغلة أن + +104 +00:08:07,010 --> 00:08:09,700 +ال lose connective tissue كميةالـ fibers و ال + +105 +00:08:09,700 --> 00:08:14,860 +cells فيها قليلة و ال .. و ال matrix بتكون فيها ال + +106 +00:08:14,860 --> 00:08:19,060 +extra cellular matrix بتكون فيها كتيرة طبعا هنا + +107 +00:08:19,060 --> 00:08:26,160 +بعض ال .. ال connective tissues اللي موجودة + +108 +00:08:26,160 --> 00:08:30,420 +ال dense طبعا هنا بحتختلف بحتصر كمية ال fibers + +109 +00:08:30,420 --> 00:08:33,760 +كتيرة و كمية ال cells كتيرة و كمية ال ground + +110 +00:08:33,760 --> 00:08:38,590 +substance أقلفهي عشان كده بتكون أقل flexibility + +111 +00:08:39,480 --> 00:08:42,960 +وبتكون مقاومة لل stress لإنه لازم يكون في عندها + +112 +00:08:42,960 --> 00:08:46,000 +قدرة على التعامل لإنه مش معقول كل ما يصير pull من + +113 +00:08:46,000 --> 00:08:51,440 +ال muscles على ال bone يصير في عندنا قطع لأ احنا + +114 +00:08:51,440 --> 00:08:55,240 +بدنا تنضن أوي عشان يقدر يتحمل ال stresses اللي + +115 +00:08:55,240 --> 00:08:58,860 +بدها تكون عليه وكمان المفاصل ال .. ال arbita طبعة + +116 +00:08:58,860 --> 00:09:04,720 +المفاصل لازم تكون أوية حتى تساعد على الحفاظ على + +117 +00:09:04,720 --> 00:09:09,680 +stability of the shrineDermis of the skin is + +118 +00:09:09,680 --> 00:09:13,160 +classified as dense irregular connective tissue + +119 +00:09:13,160 --> 00:09:16,780 +لأن ال fibers و ال bundles الموجودة فيه + +120 +00:09:16,780 --> 00:09:20,720 +disorganized و مافيش عندها orientation معين فيها + +121 +00:09:20,720 --> 00:09:24,720 +أما ال tendon و ال ligament فهي classified as + +122 +00:09:24,720 --> 00:09:27,860 +dense and regular irregular connective tissue لأن + +123 +00:09:27,860 --> 00:09:31,780 +هي عبارة عن fibers أو bundles of fibers فهذه ال + +124 +00:09:31,780 --> 00:09:34,700 +orientation دائما بتكون ال bundles of fibers هذه + +125 +00:09:35,010 --> 00:09:38,390 +الـ ligament و الـ tendon oriented parallel to + +126 +00:09:38,390 --> 00:09:42,830 +each other يعني هذه اللي بتعطيها المتانة والصلابة + +127 +00:09:42,830 --> 00:09:47,210 +أو اللي بتساعد على ال stability this arrangement + +128 +00:09:47,210 --> 00:09:50,890 +make them particularly well adapted to resisting + +129 +00:09:50,890 --> 00:09:55,550 +the traction and tensile force لإن هم على طول + +130 +00:09:55,550 --> 00:09:59,810 +بيبقوا معرضين لعملية ال pull أو ال traction أو ال + +131 +00:09:59,810 --> 00:10:03,650 +tension forcesالـ composition of tendons and + +132 +00:10:03,650 --> 00:10:08,410 +ligaments طبعا هي زي أي dense connective tissue ال + +133 +00:10:08,410 --> 00:10:11,870 +tendons and ligaments composed of two major + +134 +00:10:11,870 --> 00:10:16,790 +compartment الcell و ال extracellular matrix يعني + +135 +00:10:16,790 --> 00:10:19,790 +هو احنا قولنا ال connective tissue زي كأنها عاملة + +136 +00:10:19,790 --> 00:10:25,870 +زي cocktail أو خليطالـ cell نفسها الـ primary cell + +137 +00:10:25,870 --> 00:10:29,170 +type in the tendon and ligament هي الفيبروسايت + +138 +00:10:29,170 --> 00:10:32,870 +الفيبروسايت هي عبارة عن mature cell لما بتكلم عن + +139 +00:10:32,870 --> 00:10:36,850 +فيبروسايت هي mature cell called fibroblast لما + +140 +00:10:36,850 --> 00:10:40,850 +بتكون immature بتكون fibroblast when it is + +141 +00:10:40,850 --> 00:10:44,790 +actively manufacturing protein الفيبروسايت هي الـ + +142 +00:10:44,790 --> 00:10:53,500 +fibroblast هي خلايا البناء في ال .. في هذا النوعفي + +143 +00:10:53,500 --> 00:10:58,780 +هذا الـtype من الـcells الـcells make up only 20% + +144 +00:10:58,780 --> 00:11:02,440 +of the total tissue volume الـfibrostatic blast هي + +145 +00:11:02,440 --> 00:11:05,900 +الـmanufactures هي خلايا البناء وبتعمل secretion + +146 +00:11:05,900 --> 00:11:09,800 +للـextracellular matrix طب إيش هي الـextracellular + +147 +00:11:09,800 --> 00:11:14,080 +matrix؟ هي عبارة عن الجيلاتين أو المادة اللي بتربط + +148 +00:11:14,080 --> 00:11:19,560 +ال fibers مع بعضها فmake up + +149 +00:11:22,370 --> 00:11:27,710 +80% من الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +150 +00:11:27,710 --> 00:11:29,230 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +151 +00:11:29,230 --> 00:11:30,170 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +152 +00:11:30,170 --> 00:11:32,210 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +153 +00:11:32,210 --> 00:11:39,930 +الـ الـ الـ + +154 +00:11:39,930 --> 00:11:40,030 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +155 +00:11:40,030 --> 00:11:40,450 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +156 +00:11:40,450 --> 00:11:40,450 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +157 +00:11:40,450 --> 00:11:40,450 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +158 +00:11:40,450 --> 00:11:40,450 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ ال + +159 +00:11:40,780 --> 00:11:45,360 +طبعا of كمان ground substance طبعا لقيت هذه ال .. + +160 +00:11:45,360 --> 00:11:50,580 +ال .. ال mattress أو النسيج اللي .. اللي موجود هي + +161 +00:11:50,580 --> 00:11:54,440 +عبارة عن gelatinous material that fills the space + +162 +00:11:54,440 --> 00:12:01,140 +between cell and fibers طبعا هنا يعني الخلايا + +163 +00:12:01,140 --> 00:12:05,100 +الدعمة أو الرابطة هذه هي اللي بتربط ال extra cell + +164 +00:12:05,100 --> 00:12:10,040 +هي اللي بتربط ال fibersمع بعضها و ال cells مع ال + +165 +00:12:10,040 --> 00:12:14,560 +fibers it is composed of non-collagenous + +166 +00:12:14,560 --> 00:12:18,420 +structures زي ال glycoproteins و ال proteoglycan و + +167 +00:12:18,420 --> 00:12:25,240 +كمان ال water و هذا تقريبا قداش فيه ان نسب ل ال + +168 +00:12:25,240 --> 00:12:30,020 +water و ال collagen و ال elastin و ال proteoglycan + +169 +00:12:30,020 --> 00:12:34,340 +اللي موجودة في ال collateral ال normal media ال + +170 +00:12:34,340 --> 00:12:39,050 +collateral ligamentsطب ال fibers هي عبارة عن + +171 +00:12:39,050 --> 00:12:43,070 +collagen و هو طبعا ال collagen لونه أبيض فهو اللي + +172 +00:12:43,070 --> 00:12:48,430 +بيعطي اللون ل .. ال .. اللون الأبيض ل ال .. ال + +173 +00:12:48,430 --> 00:12:51,790 +fibers هادي أو لال ligament لأنه إذا لاحظنا إحنا + +174 +00:12:51,790 --> 00:12:54,870 +اللي بطلع على ال ligamentبيكون لونه أبيض غير عن ال + +175 +00:12:54,870 --> 00:12:58,230 +muscle ال muscle بيكون لونه أحمر لأنه هو ال muscle + +176 +00:12:58,230 --> 00:13:05,730 +مليانة blood vessels لكن هذه ال .. ال .. ال fibers + +177 +00:13:05,730 --> 00:13:10,130 +أقل طبعا ل blood vessels طبعا كنتش manufactured by + +178 +00:13:10,130 --> 00:13:15,170 +ال fibroblasts وهي قلنا الخلايا البناء اللي موجودة + +179 +00:13:15,170 --> 00:13:21,640 +أو ال immatures اللي بتعمل عملية البناءكمان الـ + +180 +00:13:21,640 --> 00:13:26,980 +Collagen matures كل ما صار mature أكرر فيه an + +181 +00:13:26,980 --> 00:13:31,640 +increase of both density and stability وكمان اللي + +182 +00:13:31,640 --> 00:13:35,780 +بتساعد على الربط which result in increased tissue + +183 +00:13:35,780 --> 00:13:39,580 +strength and stiffness many type of collagen have + +184 +00:13:39,580 --> 00:13:43,340 +been identified هم لاقوا انه فيه عند 19 يعني 19 + +185 +00:13:43,340 --> 00:13:49,040 +different collagen type موجودة في ال tendon و ال + +186 +00:13:49,040 --> 00:13:49,680 +ligaments + +187 +00:13:52,700 --> 00:13:55,580 +طبعا هنا tendon و ال ligament بتكون primarily من + +188 +00:13:55,580 --> 00:14:00,720 +type 1 او اقريبا 70% dry wet with a small amount + +189 +00:14:00,720 --> 00:14:04,920 +of type 3 يعني تلاتة في المية تقريبا من تلاتة + +190 +00:14:04,920 --> 00:14:08,680 +العشرة في المية and a trace يعني .. يعني نسبة + +191 +00:14:08,680 --> 00:14:18,600 +ضعيفة من ال type خمسة و عشرة و واحد عاش و هك + +192 +00:14:18,600 --> 00:14:23,670 +تقريبا أربعة عاشHowever, the proportion of + +193 +00:14:23,670 --> 00:14:26,750 +collagen type present various amounts specific + +194 +00:14:26,750 --> 00:14:32,130 +tendon and طبعا يعني كميات ال .. ال .. نسب لل .. + +195 +00:14:32,130 --> 00:14:35,770 +ال collagen اللي موجودة في ال tendon و ال ligament + +196 +00:14:35,770 --> 00:14:39,990 +بتختلف حسب ال ligament طبعا هنا example ال tendon + +197 +00:14:39,990 --> 00:14:43,770 +بتقريبا بيكون فيه انه type 3 collagen و ال + +198 +00:14:43,770 --> 00:14:49,910 +ligament فيه أكتر نسبة من ال type 3 collagen طيب + +199 +00:14:51,980 --> 00:14:55,980 +هلأ بالنسبة للـ Elastin الـ Elastin هي المادة + +200 +00:14:55,980 --> 00:15:02,180 +بتكون أقل موجودة في ال .. موجودة في نسب أقل في ال + +201 +00:15:02,180 --> 00:15:05,660 +.. في ال ligament في ال fibers composition of the + +202 +00:15:05,660 --> 00:15:09,300 +ligament التندن في نسبة قليلة من ال elastin عشانك + +203 +00:15:09,300 --> 00:15:13,940 +احنا ب .. يعني يكون التندن في less elasticity طبعا + +204 +00:15:13,940 --> 00:15:16,840 +ال proportion أو النسبة بين ال elastin و ال + +205 +00:15:16,840 --> 00:15:21,130 +collagen بتختلف حسبالـ ligament و مكانه و موقعه + +206 +00:15:21,130 --> 00:15:24,170 +موضوع في الأضره ولا في ال lower limb big joint + +207 +00:15:24,170 --> 00:15:28,370 +small joint حسب ال joint اللي بيكون موجود فيه in + +208 +00:15:28,370 --> 00:15:32,450 +most ligaments of the joints as in tendon ال + +209 +00:15:32,450 --> 00:15:37,050 +collagen present in much high proportion than + +210 +00:15:37,050 --> 00:15:40,830 +elastin لإن المكوّن الأكبر بيكون collagen سواء في + +211 +00:15:40,830 --> 00:15:44,110 +ال ligament أو في ال tendon + +212 +00:15:48,360 --> 00:15:52,020 +أما الـ Ground Substance فهي عبارة عن non-fibrous + +213 +00:15:52,020 --> 00:15:56,620 +part of extracellular material composed of + +214 +00:15:56,620 --> 00:16:01,480 +glycoprotein وبروتيوглиكان وكمان water إيش وظيفتها + +215 +00:16:01,480 --> 00:16:05,620 +تعمل adhesions of cells to the fibers and other + +216 +00:16:05,620 --> 00:16:10,860 +extracellular matter هي زي ال glue زي سمل اللي + +217 +00:16:10,860 --> 00:16:15,760 +بيجمع هذه الأشياء وبيربطها في بعضها + +218 +00:16:20,470 --> 00:16:26,830 +طبعا الـ protein glucan بيتمثل تقريبا أقل من 1% من + +219 +00:16:26,830 --> 00:16:32,070 +ال tendon total dry weight لكن هم ال key role + +220 +00:16:32,070 --> 00:16:38,590 +عندهم يعني بيشكلوا key role في ال ligament و ال + +221 +00:16:38,590 --> 00:16:43,610 +tendon function لإن هم بيحافظوا على ترابط الأنسجة + +222 +00:16:43,610 --> 00:16:48,620 +هذه مع بعضهاأما البروتيو .. البروتيو كليرانس also + +223 +00:16:48,620 --> 00:16:51,620 +help in regulate .. maintain the structural + +224 +00:16:51,620 --> 00:16:54,760 +organization of the tissue by providing بعض ال + +225 +00:16:54,760 --> 00:16:59,500 +support و بيعمل مساحة spacing بين ال cells و ال + +226 +00:16:59,500 --> 00:17:05,190 +fibers of connective tissueالـ vascular supply of + +227 +00:17:05,190 --> 00:17:07,950 +the tendon and ligament طبعا ال tendon و ال + +228 +00:17:07,950 --> 00:17:11,730 +ligament اللي فيهم less vascularization than ال + +229 +00:17:11,730 --> 00:17:14,530 +muscle ال muscle اللي إحنا بنعرف إنها فيها highly + +230 +00:17:14,530 --> 00:17:17,510 +vascularized ده اللي بيعطيها الشكل أو اللون الوردي + +231 +00:17:17,510 --> 00:17:20,010 +أو الأحمر أما ال tendon لأنه مافيش فيه + +232 +00:17:20,010 --> 00:17:23,690 +vascularization ف .. و بياخد طابع إن هو موجود فيه + +233 +00:17:23,690 --> 00:17:27,530 +كمية collagen أكتر فبيكون لونه مائل على البياد + +234 +00:17:27,530 --> 00:17:31,310 +أكترالـ blood vessels in the tendons represent + +235 +00:17:31,310 --> 00:17:38,530 +only about 1% ل2% of the extracellular matrix, + +236 +00:17:39,690 --> 00:17:42,130 +thus appear white compared to the highly + +237 +00:17:42,130 --> 00:17:45,410 +musculated color of the muscle from which they + +238 +00:17:45,410 --> 00:17:51,030 +originate الطيب التندن receive their blood supply + +239 +00:17:51,030 --> 00:17:55,800 +directly من وين بياخد من البريميديااللي هو الغشاء + +240 +00:17:55,800 --> 00:18:01,820 +المحيط بالعضلة أو ال outer part + +241 +00:18:01,820 --> 00:18:08,080 +of the muscle المحيط، الغشاء المحيط بالعضلة وكمان + +242 +00:18:08,080 --> 00:18:13,340 +من الberucin insertion وقتش ال tendon بيمسك بال + +243 +00:18:13,340 --> 00:18:18,080 +bone بنسمي berucin insertion بياخد التغذية وكمان + +244 +00:18:18,080 --> 00:18:23,840 +في ال surrounding tissue اللي حواليأما الـ + +245 +00:18:23,840 --> 00:18:27,180 +nutrition أو الـ neural component of the tendon + +246 +00:18:27,180 --> 00:18:33,180 +and ligament طبعا فيه يعني بتختلف خليني أقول فيه + +247 +00:18:33,180 --> 00:18:35,760 +various specialized nervous endings أو + +248 +00:18:35,760 --> 00:18:39,100 +mechanoreceptors في ال ligament وفي ال tendon ليه؟ + +249 +00:18:39,100 --> 00:18:46,730 +لأنهاهي بتساعد على انه تتحقق عملية المعرفة + +250 +00:18:46,730 --> 00:18:49,490 +الـposition تبع الجنود عن طريق الـproperception و + +251 +00:18:49,490 --> 00:18:55,910 +الـnon susceptions اللي موجودة فبتكون يعني احنا عن + +252 +00:18:55,910 --> 00:18:59,870 +طريق هذا الـnon susceptors اللي موجودة أو + +253 +00:18:59,870 --> 00:19:03,350 +الـproperceptors اللي موجودة في المفاصل اللي + +254 +00:19:03,350 --> 00:19:07,430 +موجودة في الـligament and tendon بنقدر نعرف وضعية + +255 +00:19:07,430 --> 00:19:14,960 +الـchanceأو كيف بتصير ال movement في هذا ال joint + +256 +00:19:14,960 --> 00:19:19,860 +وكمان برضه ال blood ال nervous ال nerve ending هذه + +257 +00:19:19,860 --> 00:19:25,840 +بتعمل regulation لل blood flow اللي بيروح للتنضمام + +258 +00:19:25,840 --> 00:19:30,800 +بهك احنا بنكون وصلنا لنهاية محاضرتنا لليوم ونراكم + +259 +00:19:30,800 --> 00:19:34,680 +في لقاء اخر نتكلم فيه عن ال biomechanical + +260 +00:19:34,680 --> 00:19:38,800 +properties of the ligaments + +261 +00:19:40,790 --> 00:19:41,830 +عن تنظيم + diff --git a/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/Ri56t4hkeWI_postprocess.srt b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/Ri56t4hkeWI_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..82f55dffe733d598a5cd60cdb918cca31dd17a79 --- /dev/null +++ b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/Ri56t4hkeWI_postprocess.srt @@ -0,0 +1,1868 @@ +1 +00:00:00,770 --> 00:00:03,230 +بسم الله الرحمن الرحيم و صلاة و سلام على سيدنا + +2 +00:00:03,230 --> 00:00:06,770 +محمد سيد المرسلين و على ألي و صحب أجمعين استكمالا + +3 +00:00:06,770 --> 00:00:12,850 +لما حضرتنا في مجال ال bio mechanics of joint هنخصص + +4 +00:00:12,850 --> 00:00:17,930 +المحاضرة اليوم عن موضوع ال bio mechanics of joint + +5 +00:00:17,930 --> 00:00:18,470 +flexibility + +6 +00:00:28,210 --> 00:00:33,410 +Joint flexibility احنا هنعرفها ان هي قداش المفصل + +7 +00:00:33,410 --> 00:00:40,150 +بيقدر يسمح ب range of motion طبعا ال range of + +8 +00:00:40,150 --> 00:00:44,030 +motion هذه تكون في one plan يعني نتكلم عن + +9 +00:00:44,030 --> 00:00:48,850 +flexibility of joint مثلا زي shoulder joint نتكلم + +10 +00:00:48,850 --> 00:00:53,520 +عن قداش بيسمحبال abduction قداش بسمح ب abduction + +11 +00:00:53,520 --> 00:00:59,080 +قداش بسمح ب lateral rotation او media rotation او + +12 +00:00:59,080 --> 00:01:03,040 +flexion او extension يبقى في one plan in each plan + +13 +00:01:03,040 --> 00:01:05,860 +نعرفين ان انواع المفاصل إذا بنراجع المحاضرة + +14 +00:01:05,860 --> 00:01:10,880 +السابقة بتتكلم عن انه عندنا بعض المفاصل بتشتغل في + +15 +00:01:10,880 --> 00:01:14,480 +one plan و بعضها ب two plans و بعضها ب three plans + +16 +00:01:14,480 --> 00:01:19,200 +زي ال L ب one planفالحركة اللى بيسمح فيها هي + +17 +00:01:19,200 --> 00:01:23,160 +reflection and extension يبقى احنا بنتكلم عن ال + +18 +00:01:23,160 --> 00:01:25,940 +flexibility يا اما بنتكلم عن flexibility in + +19 +00:01:25,940 --> 00:01:31,820 +extension او flexibility of reflection طبعا فى + +20 +00:01:31,820 --> 00:01:34,720 +نوعين من ال flexibility يعني ال static flexibility + +21 +00:01:34,720 --> 00:01:37,860 +وعندنا ال dynamic flexibility طبعا ال static معناه + +22 +00:01:37,860 --> 00:01:42,730 +انه عندنا مشخلّينا نقول movement خلّينا نتكلم عن + +23 +00:01:42,730 --> 00:01:46,370 +ال passive movement إذا كانت الشخص مش هو اللي + +24 +00:01:46,370 --> 00:01:52,690 +بيعمل الحركة اللي بيعملها شخص آخر أو بيستخدم اللي + +25 +00:01:52,690 --> 00:01:56,550 +هو ال machines يبقى static flexibility refers to + +26 +00:01:56,550 --> 00:01:59,810 +the range of motion present when a body segment is + +27 +00:01:59,810 --> 00:02:04,810 +passively moved by an exercise partner or + +28 +00:02:04,810 --> 00:02:08,730 +clinician أو حتى بنضيف عليه machine أو word أو + +29 +00:02:09,920 --> 00:02:13,300 +خلّين نتكلم عن external force إن العضلة مش هي اللي + +30 +00:02:13,300 --> 00:02:17,440 +بتعمل الحركة اللي بيعملها شخص آخر عشان نتكلم عنها + +31 +00:02:17,440 --> 00:02:21,040 +ساميها static flexibility أو passive flexibility + +32 +00:02:21,610 --> 00:02:25,010 +طبعا ال dynamic flexibility لما تكون الحركة is + +33 +00:02:25,010 --> 00:02:28,850 +done actively يبقى في عندنا interaction من ال + +34 +00:02:28,850 --> 00:02:31,390 +muscle، ال muscle هي اللي بتعمل الحركة، يبقى ال + +35 +00:02:31,390 --> 00:02:34,730 +dynamic flexibility refers to the range of motion + +36 +00:02:34,730 --> 00:02:38,450 +that can be achieved by actively moving body + +37 +00:02:38,450 --> 00:02:42,730 +segment طبعا باستخدام العضلات أو ال muscle + +38 +00:02:42,730 --> 00:02:46,620 +contractionطبعا ال aesthetic flexibility + +39 +00:02:46,620 --> 00:02:51,940 +considered to be the bitter indicator of the + +40 +00:02:51,940 --> 00:02:55,940 +relative tightness or laxity of the joint in term + +41 +00:02:55,940 --> 00:02:59,600 +of implication for the injury potential، إيش معانا + +42 +00:02:59,600 --> 00:03:02,980 +الكلام هذا؟ إنه لما نتكلم عن passive، إنه إحنا لما + +43 +00:03:02,980 --> 00:03:07,260 +العضلة بتعمل الحركة على الأكيدبتصير فيه limitation + +44 +00:03:07,260 --> 00:03:11,200 +من ال contralateral muscles او ال antagonist + +45 +00:03:11,200 --> 00:03:14,480 +muscle فهتوقف لكن هي اللي بتعطينا indicator اكتر + +46 +00:03:14,480 --> 00:03:19,300 +انه فيه tightness او فيه laxity هي ال passive + +47 +00:03:19,300 --> 00:03:23,260 +movement او ال static flexibility اكيد انه احنا + +48 +00:03:23,260 --> 00:03:26,460 +لما نعمل stretching لالقلب و لما نقول لنا نطلب من + +49 +00:03:26,460 --> 00:03:31,420 +المرضي بيده يعمل stretching لال biceps و يفرد ايده + +50 +00:03:31,420 --> 00:03:35,920 +على الاخر هو هيصير فيه limitationمن ال pan هتظهر + +51 +00:03:35,920 --> 00:03:39,820 +ال pan عنده و هو هيوقف لكن لو في حد تاني هو بيفرد + +52 +00:03:39,820 --> 00:03:43,400 +إيده أو بيعمله passive extension على الأكيد ال + +53 +00:03:43,400 --> 00:03:46,320 +range هتبين حقيقتها إذا كان في عندنا muscle + +54 +00:03:46,320 --> 00:03:50,020 +tightness أو إذا كان في حتى كمان laxity أو إيش + +55 +00:03:50,020 --> 00:03:54,000 +ممكن بيصير فيه شعور بإنه إيش اللي عامل limitation + +56 +00:03:54,000 --> 00:03:57,760 +لل moment هل هو ال pan حقيقي ولا هو ال tightness + +57 +00:03:57,760 --> 00:04:01,920 +هو اللي عمل ال limitation أما ال dynamic stability + +58 +00:04:03,470 --> 00:04:06,990 +must be sufficient not to restrict the range of + +59 +00:04:06,990 --> 00:04:10,870 +motion needed for daily activity or work or sport + +60 +00:04:10,870 --> 00:04:15,550 +activity يعني احنا بنتكلم عن ال limitation لازم + +61 +00:04:15,550 --> 00:04:19,370 +تكون فوقال daily activity لأن الواحد ممكن يعمل ال + +62 +00:04:19,370 --> 00:04:21,870 +daily activity حتى لو ماكنش فيه عنده flexibility + +63 +00:04:21,870 --> 00:04:26,410 +enough لأنه انت قد ما احنا لما بنبقى نشتغل بيدنا + +64 +00:04:26,410 --> 00:04:30,030 +بنشتغل بالرجل متاحة لإنا بقتش بنحس في ال + +65 +00:04:30,030 --> 00:04:32,430 +limitation اللي ما بيصير في عندنا قصور في ال + +66 +00:04:32,430 --> 00:04:36,490 +activity اللي احنا بنعتمدها طالما ال movement اللي + +67 +00:04:36,490 --> 00:04:39,470 +عندنا بتعملنا ال daily activity بتسمح لنا بنشتغل + +68 +00:04:39,470 --> 00:04:44,410 +بطريقة عادية بنعمل ال sport تبعتنا هنا مابنتكلمش + +69 +00:04:44,410 --> 00:04:44,810 +عنها + +70 +00:04:49,520 --> 00:04:53,980 +طبعا هنا اذا كنا نقص عن طبعية ال range of motion + +71 +00:04:59,330 --> 00:05:03,690 +الـ researchers أو الباحثين قالوا these two + +72 +00:05:03,690 --> 00:05:06,710 +components of flexibility are independent of each + +73 +00:05:06,710 --> 00:05:12,410 +other يعني مش متعلقين في بعضهم سواء كانت ال static + +74 +00:05:12,410 --> 00:05:16,570 +flexibility أو ال dynamic flexibility بعض الناس + +75 +00:05:16,570 --> 00:05:21,250 +قالت يعني عادة ال general flexibility compared + +76 +00:05:23,610 --> 00:05:27,390 +هي joint specific ايش معناه الكلام انه يعني ممكن + +77 +00:05:27,390 --> 00:05:30,630 +انه نلاقي مثلا نمسك ال etic ناخد عينة لو كنا في + +78 +00:05:30,630 --> 00:05:33,890 +class و ناخد بعض الطالبات هنلاقي بعض الطالبات + +79 +00:05:33,890 --> 00:05:36,750 +عندهم flexibility مثلا في ال elbow joint و بعضهم + +80 +00:05:36,750 --> 00:05:40,650 +لأ بعضهم بياخد بيعمل full extension بعضهم بيعمل + +81 +00:05:40,650 --> 00:05:46,170 +hyper extension بعضهم بيوصلش ال full extension هذا + +82 +00:05:46,170 --> 00:05:49,700 +ليه يعني انه عندها limitation في كل ال ranges؟في + +83 +00:05:49,700 --> 00:05:52,540 +ال range of movement of other joints ممكن يكون بس + +84 +00:05:52,540 --> 00:05:56,800 +هذا المفصل ممكن يكون فيه زيادة في flexibility أو + +85 +00:05:56,800 --> 00:06:01,200 +نقصان في ال flexibility يعني هنا معنى الكلام انه + +86 +00:06:01,200 --> 00:06:04,740 +هي joint specific انه ممكن تكون فيه flexibility + +87 +00:06:04,740 --> 00:06:08,140 +موجودة او فيه limitation موجودة في بعض المفاصل + +88 +00:06:08,140 --> 00:06:11,440 +ومفاصل تانية لإن احنا بلاحظ ان في ناس كتير عندهم + +89 +00:06:11,800 --> 00:06:15,200 +loss of range أو loss of flexibility في ال knee + +90 +00:06:15,200 --> 00:06:17,900 +joint هذا لا يعني أن ال upper limb ممكن يكون فيها + +91 +00:06:17,900 --> 00:06:22,900 +loss of flexibility لكن برضه احنا ممكن نعلم الناس + +92 +00:06:22,900 --> 00:06:26,180 +انه تختلف ال flexibility بين ال male and female + +93 +00:06:26,180 --> 00:06:30,920 +بين ال childrenو ال .. و ال others بين الناس اللي + +94 +00:06:30,920 --> 00:06:35,000 +هو رياضيين و الناس اللي لأ طبعا في بعض الرياضيات + +95 +00:06:35,000 --> 00:06:37,980 +لأ الرياضات بتقلل ال flexibility لإنه بيكون ال + +96 +00:06:37,980 --> 00:06:41,500 +muscle bulk أوي و ال ligament أوي فبتكون برضه ال + +97 +00:06:41,500 --> 00:06:46,570 +flexibility أقلها ده هنشوفه في باقي المحاضرةهنا + +98 +00:06:46,570 --> 00:06:50,650 +هناك عدد كبير من الاستخدام في احد المجموعات ليس + +99 +00:06:50,650 --> 00:06:55,370 +متأكد عن نفس العدد من الاستخدام في جميع المجموعات، + +100 +00:06:55,370 --> 00:06:58,910 +يعني ممكن في ناس ملاقئته من قلبه في hyperlaxity + +101 +00:06:58,910 --> 00:07:01,170 +لكن ما بنلاقي بالاخر مجموعات، في ناس ملاقئ + +102 +00:07:01,170 --> 00:07:05,950 +ريكيوفتان فنية مثلا في عندناhyper extension في ال + +103 +00:07:05,950 --> 00:07:08,910 +knee joint لكن مش شرط انه نلاقي فيه flexibility + +104 +00:07:08,910 --> 00:07:13,790 +كتيرة او زايدة في باقية المعفاصة طبعا ايش ال + +105 +00:07:13,790 --> 00:07:17,510 +factors اللي بتأثر على ال flexibility ال factors + +106 +00:07:17,510 --> 00:07:21,050 +influencing joint flexibility طبعا في عندنا + +107 +00:07:21,050 --> 00:07:24,090 +different factors اول حاجة شكل ال articulation + +108 +00:07:24,090 --> 00:07:27,170 +نفسه shape of the articulating bone surface + +109 +00:07:27,170 --> 00:07:31,570 +العضلات اللي هي بتكوناللي بتكون موجودة حوالين + +110 +00:07:31,570 --> 00:07:35,830 +المفصل الفاتش اللي بتكون موجودة لإنها ممكن إنه + +111 +00:07:35,830 --> 00:07:38,430 +العضلة مثلا إحنا بنعمل elbow flexion ال elbow + +112 +00:07:38,430 --> 00:07:40,990 +flexion إيش اللي بيحد من ال elbow flexion اللي هي + +113 +00:07:40,990 --> 00:07:44,010 +muscle bulk تبعت ال biceps كل ما كانت bulky أكتر + +114 +00:07:44,010 --> 00:07:47,110 +كل ما كان في limitation أكتر طبعا لإنه بيصير في + +115 +00:07:47,110 --> 00:07:50,990 +contact surfaces هي اللي بتمنع ال extreme range of + +116 +00:07:50,990 --> 00:07:54,590 +motion أحيانا الفات يعني مثلا نيجي بنطلب من سيدة + +117 +00:07:54,590 --> 00:07:58,960 +obese و عندها big bellyاللي بنسميه احنا الكارشوفان + +118 +00:07:58,960 --> 00:08:01,880 +هو اعمل friction of the hip joint طبعا هذه كمية + +119 +00:08:01,880 --> 00:08:06,200 +الفت هي اللي بتعمل ال limitation لل hip joint لكن + +120 +00:08:06,200 --> 00:08:09,940 +ال limitation هذه مش متعلقة بال ال pericarticular + +121 +00:08:09,940 --> 00:08:14,680 +elements اللي موجودة مثلا بالنسبة لل elbow لما + +122 +00:08:14,680 --> 00:08:17,920 +يكون في عندنا extreme hyperextension طبعا + +123 +00:08:17,920 --> 00:08:21,420 +القلقرانون هي اللي هتحدل مش هتخلى الايد تقلب لورق + +124 +00:08:21,420 --> 00:08:24,640 +معناه انه نقدر نعمل زاوية مثلا لخمسين او تسعين + +125 +00:08:24,640 --> 00:08:28,810 +درجة ليش لأنه في عندنا القلقرانونبتكون in contact + +126 +00:08:28,810 --> 00:08:32,350 +مع ال fossa of the humerus هذا هو اللي بيعمل ال + +127 +00:08:32,350 --> 00:08:36,010 +restriction لل movement في ال other direction اللي + +128 +00:08:36,010 --> 00:08:41,270 +هو ال extension طبعا + +129 +00:08:41,270 --> 00:08:44,210 +احنا زي ما شايفين في الرسم التوضيحي هذا في عنا + +130 +00:08:44,210 --> 00:08:47,750 +شايفين هنا ال olecranon و هنا ال olecranon fossa + +131 +00:08:47,750 --> 00:08:51,530 +مهما انه قلبت لهذا كل المساحة اللي بتتحرك هنا لكن + +132 +00:08:51,530 --> 00:08:58,670 +مش هتقلب لدرجات أكبرال muscle or fat on the + +133 +00:08:58,670 --> 00:09:02,190 +anterior aspect of the arm ترميت ال elbow flexion + +134 +00:09:02,190 --> 00:09:05,490 +زي ما شرحنا قلنا ال biceps طبعا لو كان في عندنا + +135 +00:09:05,490 --> 00:09:10,590 +bulky biceps بتمنع ال full أو زيادة ال elbow + +136 +00:09:10,590 --> 00:09:16,170 +flexionطبعا عادة الأشخاص اللي بتمارس رياضات بتقوى + +137 +00:09:16,170 --> 00:09:20,310 +عضلاتهم و ال muscle tone عندهم بزيد فممكن أنه و ال + +138 +00:09:20,310 --> 00:09:24,730 +.. و الأربطة طبعتهم بتكون أقوى فأكيد بيكون ال .. + +139 +00:09:24,730 --> 00:09:28,770 +ال range of motion عندهم أقل من الناس العادية يعني + +140 +00:09:28,770 --> 00:09:32,530 +في بعض الرياضات اللي بتقوى ال .. ال muscles بتعمل + +141 +00:09:32,530 --> 00:09:36,390 +restrictionللـ movement لأن ال bulky muscle بتمنع + +142 +00:09:36,390 --> 00:09:39,430 +ال complete range of motion يبقى regular + +143 +00:09:39,430 --> 00:09:43,270 +participation in bilateral asymmetrical sport زي + +144 +00:09:43,270 --> 00:09:46,570 +ال tennis مثلا ال tennis مثلا اللي بتلعب باليمين + +145 +00:09:46,570 --> 00:09:51,840 +أو باليسار عضلته بتكون أقوىفهدولة have less range + +146 +00:09:51,840 --> 00:09:55,240 +of motion for the dominant arm than for the non + +147 +00:09:55,240 --> 00:09:59,040 +-dominant arm at the glenohumeral joint shoulder، + +148 +00:09:59,040 --> 00:10:03,560 +هذا بيكون نتيجة ال bulky musculatures و القوة اللي + +149 +00:10:03,560 --> 00:10:06,900 +بتكون موجودة في الاربطة تبعتها For most + +150 +00:10:06,900 --> 00:10:10,080 +individual, joint flexibility is primarily a + +151 +00:10:10,080 --> 00:10:13,780 +function of relativeLagcity أو Extensibility لا + +152 +00:10:13,780 --> 00:10:17,480 +إيش؟ لا الـ Collagen تشيو و ال muscle crossing ده + +153 +00:10:17,480 --> 00:10:40,200 +جون + +154 +00:10:41,790 --> 00:10:49,160 +الـ flexibility of the jointطبعا ال tight ligament + +155 +00:10:49,160 --> 00:10:52,900 +أو ال tight muscle with limited extensibility هم + +156 +00:10:52,900 --> 00:10:56,960 +بيكونوا طبعا سبب في ال injury ليه؟ لأنه احنا قلنا + +157 +00:10:56,960 --> 00:11:02,420 +العضلات هذه و ال fibers هذه كل ما اتمرنت أكتر كل + +158 +00:11:02,420 --> 00:11:07,000 +ما كانت فيها درجة من السخونة عشانكي احنا دايما + +159 +00:11:07,000 --> 00:11:11,100 +بنقول لازم اي حد اللي بده يمارس رياضة بده يكون + +160 +00:11:11,100 --> 00:11:17,000 +عامل تسخين التسخين هذا اللي بنسميه احنااللي بيساعد + +161 +00:11:17,000 --> 00:11:21,560 +على تدفئة أو زيادة حرارة العضلات أو ال .. ال .. + +162 +00:11:21,560 --> 00:11:24,180 +خلّيني أقول ال ligaments اللي موجودة حولنا المفاصل + +163 +00:11:24,180 --> 00:11:30,100 +حتى تمنع ال .. ال injury طبعا هنا ال .. قداش فيه + +164 +00:11:30,100 --> 00:11:33,080 +إمكانية للعضلة إنها تتمدد أو ال ligament إنه تمدد + +165 +00:11:33,080 --> 00:11:37,500 +فأكيد ال injury بتكون نسبتها أقل لكن دايما احنا + +166 +00:11:37,500 --> 00:11:42,780 +بنقول الزجاجأكتر إشي قابل للكسر ليش؟ لأنه هو صلب + +167 +00:11:42,780 --> 00:11:47,060 +كل ما كانت مرونة الأشياء أكتر كل ما كان ال risk of + +168 +00:11:47,060 --> 00:11:51,340 +injury أقل وهذا بنطبق على ال ligaments و على ال + +169 +00:11:51,340 --> 00:11:54,620 +muscle in one study researcher shows that four + +170 +00:11:54,620 --> 00:11:58,240 +week stretching protocol طبعا هذا لما يكون أن + +171 +00:11:58,240 --> 00:12:02,000 +الشخص بتمر على مدة أربع أسابيع و بيعمل stretching + +172 +00:12:02,530 --> 00:12:06,510 +result in increased joint flexibility زادت ال + +173 +00:12:06,510 --> 00:12:09,630 +joint flexibility و زادت ال range of motion و يمكن + +174 +00:12:09,630 --> 00:12:13,110 +انتوا في بعض المثقات او التدريبات العملية لاحظته + +175 +00:12:13,110 --> 00:12:16,970 +كيف انه ممكن ان انا ازود مثلا ال flexibility تبع + +176 +00:12:16,970 --> 00:12:20,290 +ال hamstring مثلا في البداية بتكونوا بتقدروش + +177 +00:12:20,290 --> 00:12:24,610 +تبصلوا أصابعكوا في مجال اللي بنتكلم عن flexion of + +178 +00:12:24,610 --> 00:12:28,310 +the trunk لم توصلش أصابعكوا ل ال toes بعد تمرين + +179 +00:12:28,310 --> 00:12:31,900 +مرة و اتنين و تلاتةوفي نهاية المساق بتكونوا قدرتوا + +180 +00:12:31,900 --> 00:12:36,360 +توصلوا إيدكم مش بس لتوزلوا الأرض لكن هذا بيعني أنه + +181 +00:12:36,360 --> 00:12:40,620 +كمان وجدوا أنه مافيش compliance من ال muscle أو ال + +182 +00:12:40,620 --> 00:12:44,040 +muscle نفسها هذا بيأكد أنه ال ligaments و ال + +183 +00:12:44,040 --> 00:12:48,240 +tendon ممكن يكونوا أرخى شوية فصاروا فيه قدرة على + +184 +00:12:48,240 --> 00:12:52,220 +أنه يصير فيهم stretch أكتر لكن ال muscle نفسها ما + +185 +00:12:52,220 --> 00:12:55,940 +اتأثرت بالنسبة ل ال extensibility اللي هو ال + +186 +00:12:55,940 --> 00:12:57,860 +muscle ال بالي أو ال + +187 +00:13:00,530 --> 00:13:06,350 +الـ fibers سبعة ال muscle نفسها طبعا أيش علاقة ال + +188 +00:13:06,350 --> 00:13:09,630 +flexibility في ال injury لازم احنا نكون فاهمين انه + +189 +00:13:09,630 --> 00:13:13,930 +كل ما كان فيه لسه extensibility بيكون risk of + +190 +00:13:13,930 --> 00:13:17,670 +injury اعلى كل ما كان فيه لسه flexibility ال risk + +191 +00:13:17,670 --> 00:13:21,530 +of injury بيكون اعلى هنا researchers قالوا ال risk + +192 +00:13:21,530 --> 00:13:25,070 +of injury is heightened when the joint flexibility + +193 +00:13:25,070 --> 00:13:29,480 +is extremely lowأو كمان Extremely High Extremely + +194 +00:13:29,480 --> 00:13:32,780 +High معناه أنه ال nociceptors اللي موجودة أو ال + +195 +00:13:32,780 --> 00:13:36,440 +proprio-receptors اللي موجودة في المفصل ضعيفة + +196 +00:13:36,440 --> 00:13:41,040 +ماعندهاش قدرة على أنها تحمي هذا المفصل يعني لما + +197 +00:13:41,040 --> 00:13:43,820 +يكون في عندنا less of flexibility بيكون في عندنا + +198 +00:13:43,820 --> 00:13:47,740 +risk لما يكون في عندنا extreme extensibility أو + +199 +00:13:47,740 --> 00:13:51,940 +flexibility برضه بيكون في عندنا risk of injuryليش؟ + +200 +00:13:51,940 --> 00:13:57,300 +لأن أحياناً بيكون المفصل وجود الـ proprioception + +201 +00:13:57,300 --> 00:14:00,660 +اللي موجود في الـ ligament و اللي موجود في الـ + +202 +00:14:00,660 --> 00:14:04,880 +tendon هي بتمنع ال injury لو كانت ضعيفة و كان في + +203 +00:14:04,880 --> 00:14:10,980 +عيننا أربطة مرفية فأكيد ال risk of dislocation or + +204 +00:14:10,980 --> 00:14:15,340 +injury بيكون أزيادة or significantly imbalance + +205 +00:14:15,340 --> 00:14:18,500 +between the dominant و non-dominant side of the + +206 +00:14:18,500 --> 00:14:22,060 +limbطبعا هنا severely limited joint flexibility + +207 +00:14:22,060 --> 00:14:28,280 +طبعا undesirable مش مطلوبة ليش لأنه ال risk of + +208 +00:14:28,280 --> 00:14:31,840 +injury بيكون أعلى if the collagen تشيوة عن طمس ال + +209 +00:14:31,840 --> 00:14:36,220 +crossing are tied طبعا likelihoodof tearing or + +210 +00:14:36,220 --> 00:14:39,860 +rupture بالظبط اللي بيصير إنه المفصل إذا كان ال + +211 +00:14:39,860 --> 00:14:45,400 +ligament أو ال tendon كتير tough و جامد و مافي + +212 +00:14:45,400 --> 00:14:49,900 +extensively و flexibility enough أكيد ال rupture + +213 +00:14:49,900 --> 00:14:54,800 +بيكون وارد و ال risk of rupture بيكون أكتر إذا + +214 +00:14:54,800 --> 00:15:00,460 +اتعرض المفصل ل forceأكتر من ال normal range of + +215 +00:15:00,460 --> 00:15:03,880 +motion يعني إذا زودنا range of motion أكتر من + +216 +00:15:03,880 --> 00:15:07,840 +الطبيعي وكان في عندنا tight ligament or tight + +217 +00:15:07,840 --> 00:15:12,700 +tendon فأكيد ال risk of injury هيكون لالمفصل أكتر + +218 +00:15:12,700 --> 00:15:17,060 +أو لهدولة ال ligaments are or tendon أكتر وقلنا كل + +219 +00:15:17,060 --> 00:15:20,200 +ما كان فيه مرونة في الأشياء كل ما كان ال risk of + +220 +00:15:20,200 --> 00:15:24,960 +injury أو الركفر بيكون أقلطبعا ال title came from + +221 +00:15:24,960 --> 00:15:27,860 +muscle found to be related to lower extremity + +222 +00:15:27,860 --> 00:15:31,640 +injury incidence among male ليش؟ لأنه ال male احنا + +223 +00:15:31,640 --> 00:15:36,200 +بنعرف أن طبيعة تركيبة جسم ال male بتكون مختلفة + +224 +00:15:36,200 --> 00:15:38,920 +شوية عن جسم ال female و معروف أن ال female في + +225 +00:15:38,920 --> 00:15:42,740 +عندها more flexibility than male و طبعا ليش؟ + +226 +00:15:42,740 --> 00:15:46,540 +بنتكلم عن lower limb injury لأن ال lower limb + +227 +00:15:46,540 --> 00:15:52,470 +بيكونفيها بتتحمل كتير من ال weight bearing but not + +228 +00:15:52,470 --> 00:15:56,190 +female colleagues قدرتها، ده عمل على مجموعة من + +229 +00:15:56,190 --> 00:16:02,230 +طلاب التربية الرياضية في إحدى الجامعات وجدوا أنه + +230 +00:16:02,230 --> 00:16:06,740 +ال female طبعا more flexibleو have less tight + +231 +00:16:06,740 --> 00:16:11,220 +joint than ال .. ال .. ال .. المال في ال lower + +232 +00:16:11,220 --> 00:16:14,600 +extremity عشان هيك كان ال risk of injury عند المال + +233 +00:16:14,600 --> 00:16:19,900 +أعلى، يعني في سبب و نتيجة طبعا، نتيجة و النتيجة + +234 +00:16:19,900 --> 00:16:24,340 +كان إلها سببفي other study عملوا comparison بين ال + +235 +00:16:24,340 --> 00:16:28,300 +female gymnast الناس اللي كان في عندها high injury + +236 +00:16:28,300 --> 00:16:31,480 +category كانوا هم لسه flexible أما الناس اللي كان + +237 +00:16:31,480 --> 00:16:35,520 +عندهم less injury كانوا more flexible وهذا الأمر + +238 +00:16:35,520 --> 00:16:39,520 +منطقي وخليني + +239 +00:16:39,520 --> 00:16:43,920 +نقول معروف يعنيالـ alternatively and extremely + +240 +00:16:43,920 --> 00:16:48,520 +loose lacks joints، lacking in stability، ليش؟ لأن + +241 +00:16:48,520 --> 00:16:51,740 +في عندنا risk of displacement، معروف إنه إذا كان + +242 +00:16:51,740 --> 00:16:58,720 +في عندي flexibility زيادة، في عندي ligamentرافي + +243 +00:16:58,720 --> 00:17:03,500 +أكيد بيكون ال risk of dislocation موجود طبعا في + +244 +00:17:03,500 --> 00:17:07,960 +مثلا كتير من الناس اللي ممكن تتعرض تتعرض لحوادث + +245 +00:17:07,960 --> 00:17:12,320 +قوية يمكن في ناس كتير ربنا حماها و حفظها لإن كان + +246 +00:17:12,320 --> 00:17:16,140 +في عندهم bulk musculature كان فيه جسم قوي هو اللي + +247 +00:17:16,140 --> 00:17:19,600 +منع اللي منع إن الحادث يتطور لإنه صير فيه + +248 +00:17:19,600 --> 00:17:23,080 +dislocation بينما الناس اللي احنا كنا بنشوفهم إن + +249 +00:17:23,080 --> 00:17:26,660 +هم الرياضيين بيعمل searching exercisesاتعرضوا + +250 +00:17:26,660 --> 00:17:29,940 +النصارى عندهم dislocation ليش؟ لأنه في كان خليني + +251 +00:17:29,940 --> 00:17:33,420 +نقول مافيش حماية كفاية للمفصل تبعهم على طريق ال + +252 +00:17:33,420 --> 00:17:39,320 +ligaments و ال pericarticular musculatures and + +253 +00:17:39,320 --> 00:17:44,270 +tendon اللي هي وظيفتها كمان انها تحمي المفصلThe + +254 +00:17:44,270 --> 00:17:47,650 +desirable and amount of joint flexibility largely + +255 +00:17:47,650 --> 00:17:50,290 +dependent on the activity in which the individual + +256 +00:17:50,290 --> 00:17:54,270 +wishes to engage طبعا ال flexibility اللي بيحتاجها + +257 +00:17:54,270 --> 00:17:58,050 +بتحتاجها الجيمناست أو اللي بيحتاجها ال dancers و + +258 +00:17:58,050 --> 00:18:00,950 +اللي بيحتاجها الناس بتختلف عن ال flexibility اللي + +259 +00:18:00,950 --> 00:18:05,490 +بيحتاجها لاعب الكرة أو لعب الحديد يعني اللاعب + +260 +00:18:05,490 --> 00:18:08,450 +الحديد ما بيحتاجها داك اللي بيحمل الحديد محتاجش ال + +261 +00:18:08,450 --> 00:18:11,990 +flexibility اللي بيحتاجها ال gymnast أو ال dancer + +262 +00:18:12,570 --> 00:18:16,450 +أو كمان هدولة انه الناس العادين مابيحتاج ان تكون + +263 +00:18:16,450 --> 00:18:20,130 +هداك ال .. ال .. ال flexibility ال .. ال .. يعني + +264 +00:18:20,130 --> 00:18:23,450 +الإنسان العادي زي ال dancers أو ال gymnast اللي + +265 +00:18:23,450 --> 00:18:27,950 +بيلعبوا رياضات أو اللي بيلعبوا الجمباز و الشقلبات + +266 +00:18:27,950 --> 00:18:32,740 +هذه اللي بتصير يعنيطبعا ماحدش يسأل عن موضوع الناس + +267 +00:18:32,740 --> 00:18:36,240 +اللي بيكون في عندهم hyper flexibility زي الناس + +268 +00:18:36,240 --> 00:18:39,680 +اللي بتقلب لورا مثلا الناس اللي بتقدر تحط رأسها + +269 +00:18:39,680 --> 00:18:42,420 +بين أجريها و هي في ال standing بدون ما تعمل + +270 +00:18:42,420 --> 00:18:47,200 +reflection و هيك دول عندهم قدرات خارقة و خلينا + +271 +00:18:47,200 --> 00:18:51,980 +نقول في تركيبة خاصة للعضلات و للمفاصل تبعتهم + +272 +00:18:51,980 --> 00:18:56,680 +بتختلف عن الناس العادية و هذه مواهب ربنا يعني + +273 +00:18:56,680 --> 00:19:01,870 +خلقها في بعض الناس و مش موجودة في كل الناسHowever + +274 +00:19:01,870 --> 00:19:05,030 +these athletes also require strong muscle, tendon + +275 +00:19:05,030 --> 00:19:09,210 +and ligament ليش؟ عشان هم يقدروا يعملوا ال + +276 +00:19:09,210 --> 00:19:13,510 +activity تبعتهم أو الاستعراضات تبعتهم بدون ما يصير + +277 +00:19:13,510 --> 00:19:18,110 +في عندهم أي injuryال large bulking muscle طبعا + +278 +00:19:18,110 --> 00:19:23,010 +بتقلل ال range of motion كيف بتقللها لأن هي أساسا + +279 +00:19:23,010 --> 00:19:30,230 +strong بتعطيني stable joint و كمان بتعطيني range + +280 +00:19:30,230 --> 00:19:34,790 +of motion يعني احنا لما نطلب من عضلةنطلب من شخص + +281 +00:19:34,790 --> 00:19:38,270 +أنه يعمل عضلة لو كانت عنده العضلات قوية أكيد هي + +282 +00:19:38,270 --> 00:19:43,070 +بتقدر تعمل تفرد المفصل وتتنيق بقوة أكتر من العضلات + +283 +00:19:43,070 --> 00:19:47,570 +الضعيفة لكن أحيانا بتكون معوقة لل complete range + +284 +00:19:47,570 --> 00:19:51,570 +of motion اللي ممكن الشخص كان pure form ال + +285 +00:19:51,570 --> 00:19:55,530 +athletes and recreational runners عادة بيعملوا بعض + +286 +00:19:55,530 --> 00:20:01,230 +ال stretching exercise قبل ال هذا اللي احنا + +287 +00:20:01,230 --> 00:20:05,810 +بنسميها ال wormال warm-up احنا عارفين انه اي + +288 +00:20:05,810 --> 00:20:09,650 +exercise او heavy exercise لازم يكون مسبوك بال + +289 +00:20:09,650 --> 00:20:14,050 +warm-up وينتهي بال cool-down حتى يعمل عملية تسقين + +290 +00:20:14,050 --> 00:20:19,190 +لالاوتهيقة للعضلات لعملية ال activity اللي بدها + +291 +00:20:19,190 --> 00:20:22,090 +تنعمل زي ال runners بيعملوا بعض ال stretching حتى + +292 +00:20:22,090 --> 00:20:26,530 +مايصيرش عندهم تقلصات أثناء الجريبالطبع هناك بعض + +293 +00:20:26,530 --> 00:20:31,630 +الوثيقة بأن المشاركة في التنسيق يقلل تنسيق الضغط، + +294 +00:20:31,630 --> 00:20:35,430 +وهذا معروف لأن الـ warm-up عادة تقلل حرارة + +295 +00:20:35,430 --> 00:20:40,330 +المصابة، كمان عملية عملية عملية عملية عملية عملية + +296 +00:20:40,330 --> 00:20:40,590 +عملية عملية عملية عملية عملية عملية عملية عملية + +297 +00:20:40,590 --> 00:20:40,950 +عملية عملية عملية عملية عملية عملية عملية عملية + +298 +00:20:40,950 --> 00:20:42,210 +عملية عملية عملية عملية عملية عملية عملية عملية + +299 +00:20:42,210 --> 00:20:43,130 +عملية عملية عملية عملية عملية عملية عملية عملية + +300 +00:20:43,130 --> 00:20:43,170 +عملية عملية عملية عملية عملية عملية عملية عملية + +301 +00:20:43,170 --> 00:20:48,660 +عملية عملية عملية عملية عملالذي يسيطر على ايسانترك + +302 +00:20:48,660 --> 00:20:54,460 +اكسيرسايز اندووز مصل دمشط طبعا احنا بعض اللي نعرف + +303 +00:20:54,460 --> 00:21:00,500 +ان ايسانترك اكسيرسايز للمصل هذا عادة بتصير عملية + +304 +00:21:00,500 --> 00:21:05,980 +stretching اثناء ال motion او ال resistanceعبارة + +305 +00:21:05,980 --> 00:21:10,220 +العضلة بتكون بتعمل contraction أو tension against + +306 +00:21:10,220 --> 00:21:14,460 +resistant لكن بالحقيقة اللى بيصير بيصير فيها + +307 +00:21:14,460 --> 00:21:20,060 +tension الخيوط طبعة العضلة بتتباعد مش بتتقارب عشان + +308 +00:21:20,060 --> 00:21:23,540 +هي كده قبلها لو كنا مسابقينها بعض ال flexibility + +309 +00:21:23,540 --> 00:21:27,360 +exercise أو ال stretching بقل risk of injury + +310 +00:21:27,690 --> 00:21:34,030 +السريتشنج ليس لديه اثر على الانجري الاساسي هو انه + +311 +00:21:34,030 --> 00:21:38,830 +اساسي هذا ممكن انه يعمل micro damage في العضلات + +312 +00:21:38,830 --> 00:21:44,410 +ويأثر على ال .. او كمان على ال ligaments الموجودة + +313 +00:21:44,410 --> 00:21:48,150 +في المفاصل although people usually become less + +314 +00:21:48,150 --> 00:21:52,930 +flexible as they age طبعا بالعمر طبعا كل اللي بتقل + +315 +00:21:52,930 --> 00:21:58,690 +ال flexibility تعرفين ال intracellular fluid بلبس + +316 +00:21:58,690 --> 00:22:02,970 +ال extra salary طبعا ما بيقلش هنا بيصير في عندنا + +317 +00:22:02,970 --> 00:22:10,310 +ال decrease الفيروفيزيكال activity بيأثر مع ال age + +318 +00:22:10,310 --> 00:22:16,390 +هو اللي بيقلل ال flexibility عند هدول الناسطبعاً + +319 +00:22:16,390 --> 00:22:20,290 +لا تغيير في التطبيقات التي كانت وجدت أنها مرتبطة + +320 +00:22:20,290 --> 00:22:24,390 +بالتطوير في أصول الأطفال، لأ يعني خلينا نقول هذه + +321 +00:22:24,390 --> 00:22:28,830 +الجملة قبل أن نصحيها إنه في الـ childhood بيكون ال + +322 +00:22:28,830 --> 00:22:32,550 +flexibility أكتر، في ال adolescence لأ مافيش + +323 +00:22:32,550 --> 00:22:36,310 +تغيير، بعد هيك مع الاجن بتقل ال flexibility زي ما + +324 +00:22:36,310 --> 00:22:40,490 +شوفنا فالوصول للعديد من الدراسات تشير إلى أن + +325 +00:22:40,490 --> 00:22:45,590 +التطبيقات يمكن أن تكون كثيرةincrease among elderly + +326 +00:22:45,590 --> 00:22:50,750 +individuals اللي بيعملوا participation in a + +327 +00:22:50,750 --> 00:22:54,170 +program of regular stretching and exercise هذا + +328 +00:22:54,170 --> 00:22:57,550 +يعني اللي هي صحيح في ال elderly بتقلي flexibility + +329 +00:22:57,550 --> 00:23:02,610 +لكن لو احنا عملنا exercise او regular exercise of + +330 +00:23:02,610 --> 00:23:08,570 +stretching لأ بتظل المفاصل تبعتهم والعضلات عندهم + +331 +00:23:08,570 --> 00:23:14,610 +flexibleطبعا نشوف إيش تأثير ال external forces على + +332 +00:23:14,610 --> 00:23:19,590 +المفصل هنا هنتكلم عن ال interaction between ال + +333 +00:23:19,590 --> 00:23:22,790 +forces في عندنا environment اللي هي ال external + +334 +00:23:22,790 --> 00:23:26,690 +force و في عندنا ال internal forces بتأثر على + +335 +00:23:26,690 --> 00:23:33,370 +العضلات لإن انت عارفين أن العضلة هي اللي بتعمل ال + +336 +00:23:33,370 --> 00:23:39,400 +movement اللي جامد هو اللي بيربطالمفصل طبعا ال + +337 +00:23:39,400 --> 00:23:43,060 +forces ممكن تكون نتيجة ال weight bearing مثلا أو + +338 +00:23:43,060 --> 00:23:46,100 +ال external weight أما ال internal force فهي ال + +339 +00:23:46,100 --> 00:23:49,520 +muscle pull و ال action اللي بتعمله ال ligament + +340 +00:23:49,520 --> 00:23:52,940 +حتى تحافظ على المفصل في مكانهطبعا the weight of + +341 +00:23:52,940 --> 00:23:56,380 +the limb and the force of additional loads زي ال + +342 +00:23:56,380 --> 00:23:59,280 +manual resistance applied to by the therapist اللي + +343 +00:23:59,280 --> 00:24:03,720 +هنشوفها بالصورة في عندنا هيكون moment هو اللي + +344 +00:24:03,720 --> 00:24:07,920 +بيعمل ال joint movement طبعا في مقاومة بتكون من ال + +345 +00:24:07,920 --> 00:24:14,830 +therapist وكمان في pull من العضلاتطبعا these are + +346 +00:24:14,830 --> 00:24:17,850 +counteracted by the movement of the terc produced + +347 +00:24:17,850 --> 00:24:20,510 +by the muscle and ligament زي ما احنا شايفين + +348 +00:24:20,510 --> 00:24:24,610 +بالصورة هنا ال hamstrings اللي بتعمل knee flexion + +349 +00:24:24,610 --> 00:24:30,310 +و هنا ال weight of the body اللي بيعمل tend to do + +350 +00:24:30,310 --> 00:24:35,230 +knee flexion و هنا ال resistant من ال therapist + +351 +00:24:35,230 --> 00:24:41,260 +طبعا هناال therapist بيقاوم هنا المريض بالعضلة هذه + +352 +00:24:41,260 --> 00:24:45,460 +بيتني ال ال knee و كمان ال weight of the body + +353 +00:24:45,460 --> 00:24:50,880 +بيساعده هذا كله بيأثر على مفصل ال knee و على + +354 +00:24:50,880 --> 00:24:56,680 +الأداء داخل المفصلإذا كانت ال external force and + +355 +00:24:56,680 --> 00:25:00,380 +moment balanced مع ال internal force يعني ال + +356 +00:25:00,380 --> 00:25:04,000 +movement هتكون فيها equilibrium و هتكون static و + +357 +00:25:04,000 --> 00:25:09,070 +مش هتكون فيه عند ال movement يعني لو ال weightof + +358 +00:25:09,070 --> 00:25:13,350 +the limb مع ال muscle ال power of hamstring + +359 +00:25:13,350 --> 00:25:18,250 +اتوازنت مع المقاومة اللى عملها ال therapist اكيد + +360 +00:25:18,250 --> 00:25:23,730 +هنحصل على static movement و مش هيكون في عيننا حركة + +361 +00:25:23,730 --> 00:25:27,650 +لكن لو واحدة منهم زادت عن التانية اكيد هيكون في + +362 +00:25:27,650 --> 00:25:31,190 +حركة يا اما في اتجاه reflection of the knee او ال + +363 +00:25:31,190 --> 00:25:37,060 +extension of the kneeIdentification and + +364 +00:25:37,060 --> 00:25:41,060 +characterization of the external force applied to + +365 +00:25:41,060 --> 00:25:43,980 +a joint during activity help a clinician to + +366 +00:25:43,980 --> 00:25:47,400 +determine the muscle or ligament needed to move or + +367 +00:25:47,400 --> 00:25:54,030 +stabilize joint طبعا many jointsعشان تحرك مثلا + +368 +00:25:54,030 --> 00:26:01,090 +مفصل من المفاصل محتاج انه حركة او تداخل من مفاصل + +369 +00:26:01,090 --> 00:26:04,290 +اخرى يبقى many joints in the body sustain very + +370 +00:26:04,290 --> 00:26:07,990 +large joint reaction force during normal daily + +371 +00:26:07,990 --> 00:26:10,810 +activity لان في ال daily activity اللي احنا + +372 +00:26:10,810 --> 00:26:14,090 +بنعملها ممكن تكون في ال open chain و ممكن تكون في + +373 +00:26:14,090 --> 00:26:17,420 +ال closed chainعشان طبعا احنا لما بنمشي في حال في + +374 +00:26:17,420 --> 00:26:20,000 +ال .. في ال locomotion في رجل دائما بتكون على + +375 +00:26:20,000 --> 00:26:24,500 +الأرض و في رجل عادة بتكون هي اللي بت .. اللي + +376 +00:26:24,500 --> 00:26:29,780 +بتنتقل هنا طبعا اللي بيحدد ال .. ال forces هذه او + +377 +00:26:29,780 --> 00:26:34,800 +اللي بيحدد ال .. مين بده يدخل من ال .. ال joints + +378 +00:26:34,800 --> 00:26:39,560 +هوطبعا إيش طبيعة الحركة اللي إحنا بنعملها ال + +379 +00:26:39,560 --> 00:26:42,980 +surface area over which the joint reaction force + +380 +00:26:42,980 --> 00:26:45,620 +is applied to determine the stress اللي هو ال + +381 +00:26:45,620 --> 00:26:50,060 +force على ال area that the joint sustained during + +382 +00:26:50,060 --> 00:26:55,670 +the activityهنتكلم إنه دايما ال stress اللي هيتعرض + +383 +00:26:55,670 --> 00:27:02,090 +عليه المفصل بيعتمد على القوة اللي جاية على المفصل + +384 +00:27:02,090 --> 00:27:06,430 +على ال area و طبعا احنا عارفين إنه في تناسب عكسي + +385 +00:27:06,430 --> 00:27:12,230 +في .. في .. بين ال area و بين ال stressChanges in + +386 +00:27:12,230 --> 00:27:15,170 +the joint surface or alignment can alter the + +387 +00:27:15,170 --> 00:27:18,390 +stress applied on the joint يعني زي ما اتكلم عن لو + +388 +00:27:18,390 --> 00:27:24,030 +صار في عندنا مثلا في knee joint صار في عندنا مشكلة + +389 +00:27:24,030 --> 00:27:30,420 +في القربطة أو كان عندنا مشكلةفي ال disk اللي موجود + +390 +00:27:30,420 --> 00:27:35,800 +في الرقبة طبعا أكيد حيصل فيه تغيير في توزيع ال + +391 +00:27:35,800 --> 00:27:41,080 +forces اللي موجودة على مفصل الرقبة وهذا بيقدر ل + +392 +00:27:41,080 --> 00:27:45,820 +pain أو degeneration في الرقبة + +393 +00:27:53,930 --> 00:27:56,950 +طب هنا الـ joint reaction forces that occur during + +394 +00:27:56,950 --> 00:28:00,630 +exercise and functional activity influence by rest + +395 +00:28:00,630 --> 00:28:03,890 +factors زي ال joint position و method of + +396 +00:28:03,890 --> 00:28:07,790 +application و external forces يعني احنا لو اتكلمنا + +397 +00:28:07,790 --> 00:28:11,770 +عن ال moment بس لحاله لو في مفصل ال knee او القلم + +398 +00:28:11,770 --> 00:28:14,670 +و ناخد مفصل ال knee لو كانت ال force اللي applied + +399 +00:28:14,670 --> 00:28:20,430 +by the therapist قريبة من ال kneeهيكون ال moment R + +400 +00:28:20,430 --> 00:28:24,550 +صغير فال force النجلة هتكون قليلة هتختلف طبعا + +401 +00:28:24,550 --> 00:28:29,270 +توزيع ال force على المفصل نفسه بينما لو كانت ال + +402 +00:28:29,270 --> 00:28:33,530 +force اللي applied من ال therapist على ال lower + +403 +00:28:33,530 --> 00:28:37,530 +legمعناه تبدأ شوية شرح عملي، بيكون طبعا ال moment + +404 +00:28:37,530 --> 00:28:41,590 +arm كبير، طبعا ال moment الناتج هيكون أكبر و بحتاج + +405 +00:28:41,590 --> 00:28:48,230 +أنه قوة أكبر من العضلات عشان تعمل المقاومة، + +406 +00:28:48,230 --> 00:28:55,170 +بالتالي هذا هيأثر على ال joint نفسه طبعا ال + +407 +00:28:55,170 --> 00:28:58,250 +clinicians must design ال exercise and functional + +408 +00:28:58,250 --> 00:29:02,530 +activity that minimize reaction for to protect the + +409 +00:29:02,530 --> 00:29:06,180 +joint surfaceإنه إحنا لو بدنا نعمل مقاومة لل knee + +410 +00:29:06,180 --> 00:29:10,760 +extension، إذا كانت لسه ال knee مش completely + +411 +00:29:10,760 --> 00:29:15,360 +خلينا نقول healed، بنعمل protection، فالمقاومة + +412 +00:29:15,360 --> 00:29:18,680 +تبعتنا بتكون حوالين المفصل عشان نقلل moment R، + +413 +00:29:18,680 --> 00:29:23,510 +نقلل risk of injuryلكن إذا كنا قاعدين في ال later + +414 +00:29:23,510 --> 00:29:27,210 +stage أو كان المرض عاملا بيتعافى و ال muscle power + +415 +00:29:27,210 --> 00:29:31,690 +وصلت عنده مثلا ل 4 و نصف ل 4 و خمسة فإحنا كل ما + +416 +00:29:31,690 --> 00:29:35,090 +أبعدنا بإيدنا كل ما زاد ال moment و كل ما زاد ال + +417 +00:29:35,090 --> 00:29:39,170 +force اللي هو بيحتجوا طبعا ال human body بتكون من + +418 +00:29:39,170 --> 00:29:43,750 +تقريبا 150 هذا ال interaction between the joints + +419 +00:29:43,750 --> 00:29:48,450 +and the environmentsفي عندنا تقريبا 150 joint + +420 +00:29:48,450 --> 00:29:51,690 +moment of one joint affect several nearby joint + +421 +00:29:51,690 --> 00:29:56,850 +طبيعي this particularly true when movingلنب اذا + +422 +00:29:56,850 --> 00:30:00,090 +كان اتكلم عن closed chain او open chain اذا كان + +423 +00:30:00,090 --> 00:30:05,650 +fixed طبعا احنا لما نقول ان نعمل elbow flexion لو + +424 +00:30:05,650 --> 00:30:08,830 +كانت الايد ممتوضة على الجنب بس بحتاج انه يعمل + +425 +00:30:08,830 --> 00:30:12,850 +الحركة في ال elbow لكن لو كان هو في closed مثلا + +426 +00:30:12,850 --> 00:30:18,130 +ايده محطوطة على ال .. ال .. ال punch او على ال + +427 +00:30:18,130 --> 00:30:23,910 +wall فممكن هو مش هيقدر يعمل flexion الا اذا حرك ال + +428 +00:30:23,910 --> 00:30:28,590 +wrist و الشوردانfor example when one is standing + +429 +00:30:28,590 --> 00:30:32,410 +upright, the arm at the side of the body، طبعا ال + +430 +00:30:32,410 --> 00:30:35,650 +hand free، reflection of the knee عادة بيكون من + +431 +00:30:35,650 --> 00:30:38,970 +غير أي interaction من ال other joints، لا من + +432 +00:30:38,970 --> 00:30:41,590 +الشoulder ولا من ال wrist، لكن لو كان ال elbow + +433 +00:30:42,090 --> 00:30:47,430 +موجود لو كانت ال hand في claws أو بيعمل push up أو + +434 +00:30:47,430 --> 00:30:50,770 +حاطط إيده على الحات مش ممكن يعمل affliction إلا + +435 +00:30:50,770 --> 00:30:54,310 +إذا اتحرك ال wrist و اتحرك ال shoulder فهذه ممكن + +436 +00:30:54,310 --> 00:30:57,430 +كل كوا تجربوا ال push ups لازم يكون في حركة من + +437 +00:30:57,430 --> 00:31:01,820 +الشoulder عشان يقدر يتني و يفرد الكواطبعا في ال + +438 +00:31:01,820 --> 00:31:05,320 +first case إحنا بنسميها إذا كانت ال hand free فهو + +439 +00:31:05,320 --> 00:31:09,120 +open chain أو open kinematic أو open kinetic chain + +440 +00:31:09,120 --> 00:31:15,240 +لكن إذا كان ال البا .. إذا كانت ال hand on a + +441 +00:31:15,240 --> 00:31:19,700 +surface في ال push up فبيسمى ال closed kinetic + +442 +00:31:19,700 --> 00:31:25,140 +chain أو closed kinematic أو closed chainهذا + +443 +00:31:25,140 --> 00:31:29,040 +بينطبق على حركة ال lower limb ممكن تكون في ال + +444 +00:31:29,040 --> 00:31:32,240 +standing position مثلا لل squat احنا بنعمل knee + +445 +00:31:32,240 --> 00:31:35,140 +flexion مقدرش نعمل ال knee flexion الا اذا كان في + +446 +00:31:35,140 --> 00:31:39,220 +دورس ال flexion في ال ankle و في عندنا flexion of + +447 +00:31:39,220 --> 00:31:43,100 +the hip بينما الا اذا كان الشخص قاعد على الكرسي او + +448 +00:31:43,680 --> 00:31:48,640 +وقف على one limb بيقدر يعمل اني حتى برضه مابيقدرش + +449 +00:31:48,640 --> 00:31:50,720 +يعمل knee flexion في الوقوف إلا إذا قاعد على + +450 +00:31:50,720 --> 00:31:54,860 +الكرسي هو بيقدر يعمل performance ل knee flexion لو + +451 +00:31:54,860 --> 00:31:57,960 +واحدة this is described as a closed chain + +452 +00:31:57,960 --> 00:32:01,620 +conditionSince the movement joint of the upper + +453 +00:32:01,620 --> 00:32:05,600 +extremity lie between relatively immovable load on + +454 +00:32:05,600 --> 00:32:08,700 +the floor طبعا movement of any joint in the closed + +455 +00:32:08,700 --> 00:32:15,320 +chain لازم تتدخل فيها other joints طبعا lower + +456 +00:32:15,320 --> 00:32:18,380 +extremity ممكن تعمل function في ال open و في ال + +457 +00:32:18,380 --> 00:32:22,540 +closedmuscle, shape, condition طبعا و هذا كله احنا + +458 +00:32:22,540 --> 00:32:26,560 +بنشوفه في ال locomotion طبعا اذا اتكلمنا عن ال + +459 +00:32:26,560 --> 00:32:31,840 +kicking لل ball لما بنيجي نضرب ال ball the end of + +460 +00:32:31,840 --> 00:32:35,360 +the kicking lead is not flex طبعا ان هذه بتشتغل في + +461 +00:32:35,360 --> 00:32:39,120 +ال open chain طبعا المفاصل مابتشتغلش معتمدة على + +462 +00:32:39,120 --> 00:32:43,560 +الأفراد كل مفصل بيشتغل لحاله independentare + +463 +00:32:43,560 --> 00:32:47,620 +independent of one another غير معتمدين على بعض أما + +464 +00:32:47,620 --> 00:32:51,820 +في ال sensing اللي هي رجل الواقع أكيد حركة أي مفصل + +465 +00:32:51,820 --> 00:32:56,700 +منها لازم تعتمد على المفصل التاني + +466 +00:32:58,040 --> 00:33:01,060 +For example, flexion of the stance knee requires + +467 +00:33:01,060 --> 00:33:04,840 +ankle dorsiflexion and hip flexion + diff --git a/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/S4YmK5W4O6Q_postprocess.srt b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/S4YmK5W4O6Q_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..5448b3fc47458ff3f2f30b91fae3827ab5fffa34 --- /dev/null +++ b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/S4YmK5W4O6Q_postprocess.srt @@ -0,0 +1,1688 @@ +1 +00:00:01,180 --> 00:00:03,560 +بسم الله الرحمن الرحيم الصلاة والسلام على سيدنا + +2 +00:00:03,560 --> 00:00:07,800 +محمد سيد المرسلين وعلى أله وصحبه أجمعين استكملنا + +3 +00:00:07,800 --> 00:00:11,880 +محاضرتنا في مسحق ال bio mechanics two اليوم وصلنا + +4 +00:00:11,880 --> 00:00:18,040 +تقريبا لآخر محطة هي ال bio mechanics of joints + +5 +00:00:18,040 --> 00:00:21,180 +هنتعرف على أنواع ال joints هنتعرف على stability + +6 +00:00:21,180 --> 00:00:25,900 +تبع ال joints على ال flexibilityبداية لازم نتعرف + +7 +00:00:25,900 --> 00:00:32,760 +على أنواع ال joints اللي موجودة في شسم الإنسان + +8 +00:00:32,760 --> 00:00:36,540 +طبعا في البداية بناعرف إيش هو ال joint ال joint هو + +9 +00:00:36,540 --> 00:00:41,080 +عبارة عن ال site of motion between ال articulating + +10 +00:00:41,080 --> 00:00:44,440 +bone يعني أنه بنانفهم أن ال joint هو تعريفه هو + +11 +00:00:44,440 --> 00:00:49,440 +عبارة عن المفصل اللي بيربط two bones أو two bone + +12 +00:00:49,440 --> 00:00:55,190 +endsطبعا هدول ال bone بيكونوش بس يعني مشبوكين مع + +13 +00:00:55,190 --> 00:01:00,350 +بعض كده بدون أي وسائل حماية وسائل الحماية بتكون + +14 +00:01:00,350 --> 00:01:03,710 +مربطاهم عن طريق ال connective tissue structure + +15 +00:01:03,710 --> 00:01:07,810 +اللي وظفتها إنها تحافظ على ال integrity of the + +16 +00:01:07,810 --> 00:01:11,780 +junction وكمان بدها تحافظ على ال movementيعني هنا + +17 +00:01:11,780 --> 00:01:14,460 +بدنا نركز على شغلتين في ال joint ال joint لازم + +18 +00:01:14,460 --> 00:01:18,440 +يكون بتمتع بحاجتين أساسيات ال mobility و ال + +19 +00:01:18,440 --> 00:01:21,980 +stability طبعا أكبر تحدي عند المفصل عند أي مفصل + +20 +00:01:21,980 --> 00:01:27,180 +احنا يعني بيكون في حركة بدو يكون هو ال mobility و + +21 +00:01:27,180 --> 00:01:30,240 +ال stability كيف أنه يصير في توازن بين ال mobility + +22 +00:01:30,240 --> 00:01:34,400 +و ال stability؟مقدش في توازن بين هدول التنتين احنا + +23 +00:01:34,400 --> 00:01:38,140 +قولنا دايما في تناسب عكسي ما بين ال mobility و ال + +24 +00:01:38,140 --> 00:01:41,740 +stability كل ما زادت ال mobility كل ما قلت ال + +25 +00:01:41,740 --> 00:01:45,680 +stability وهذا الاشي واقعي ومنطقي حتى في حياتنا + +26 +00:01:45,680 --> 00:01:52,530 +العملية بعيدا عن المفاصل طيب هذا المفصلأو هذه كمية + +27 +00:01:52,530 --> 00:01:55,570 +ال mobility و ال stability هتختلف من مفصل لمفصل + +28 +00:01:55,570 --> 00:02:00,050 +هتعتمد على أشياء كتيرة في انها مفاصل ثابتة جدا و + +29 +00:02:00,050 --> 00:02:03,210 +stability فيها عالية لأنها برضه كمان ال mobility + +30 +00:02:03,210 --> 00:02:10,730 +فيها قليلة جدا زي ال ال joint اللي موجود في ال + +31 +00:02:10,730 --> 00:02:14,680 +skullطبعا هدول الجنت الموجودة في ال .. في ال skull + +32 +00:02:14,680 --> 00:02:19,360 +هي إن خلقت ربنا سبحانه وتعالى خلقها حتى ت .. تكون + +33 +00:02:19,360 --> 00:02:24,460 +ت .. يعني توجد مساحة لنمو .. لنمو الجمجمة لإنه مش + +34 +00:02:24,460 --> 00:02:28,520 +معقول إن الإنسان ينولد بجمجمة كبيرةأكيد يعني بيصير + +35 +00:02:28,520 --> 00:02:31,580 +فترة النمو فانتركت الفتحات هذه اللي موجودة أو + +36 +00:02:31,580 --> 00:02:35,420 +المفاصل اللي موجودة حتى تسمع في عملية النمو كان في + +37 +00:02:35,420 --> 00:02:39,920 +أساسا فتحات ممكن تصير لها ضغط أثناء عملية الميلاد + +38 +00:02:39,920 --> 00:02:44,860 +وهذه مع ال growing أو مع ال age بتت .. بتتسكر و + +39 +00:02:44,860 --> 00:02:51,910 +بتصبح مفاصل شبه ثابتةطبعا في بعض المفاصلة التانية + +40 +00:02:51,910 --> 00:02:57,330 +زي ال shoulder زي ال hip joint فهي فيها mobility + +41 +00:02:57,330 --> 00:03:01,910 +خلينا نقول عالية لأنها بدها تسمح بالحركة في range + +42 +00:03:01,910 --> 00:03:05,910 +of motion و wide range of motion فعادة بتكون لسه + +43 +00:03:05,910 --> 00:03:10,650 +stable يعني لو اتكلمنا عن ال glenohumeral joint of + +44 +00:03:10,650 --> 00:03:14,880 +the shoulder فهوأكتر جوينت في الجسم هو mobile + +45 +00:03:14,880 --> 00:03:19,100 +وكمان هو أكتر جوينت لسه stable، ليش؟ لأنه بتمتع + +46 +00:03:19,100 --> 00:03:24,260 +بmobility عالية لكن الأكيد ال stability تبعته أقل + +47 +00:03:24,260 --> 00:03:27,800 +لأنه احنا هنتعرف على إيش العوامل اللي بتساعد على + +48 +00:03:27,800 --> 00:03:32,840 +زيادة ال stability وعلى زيادة ال mobility ال most + +49 +00:03:32,840 --> 00:03:37,560 +movable joint must demonstrate combination between + +50 +00:03:37,560 --> 00:03:41,630 +stability and mobilityعساس ان تعطينا stable + +51 +00:03:41,630 --> 00:03:46,450 +movement ال stable movement هذه بتتمكننا من ال + +52 +00:03:46,450 --> 00:03:52,190 +function طيب لقيت انا عشان انا احمل شغلة على ايه + +53 +00:03:52,190 --> 00:03:56,390 +بايدي لازم يكون في عندي ثبات في مفصل الكتف مثلا + +54 +00:03:56,390 --> 00:03:59,530 +عشان اكل لازم يكون في عندي ثبات في كل مفاصل ال + +55 +00:03:59,530 --> 00:04:03,510 +upper limb عشان امشي برضه لازم يكون في نهاية ال + +56 +00:04:03,510 --> 00:04:07,740 +motion هذه اللي انا بتمنى ان اعملهاأو بدي أعملها + +57 +00:04:07,740 --> 00:04:11,140 +لازم تكون functional و ال function بدها stability + +58 +00:04:11,140 --> 00:04:14,660 +لإني اذا بدى أمسك كباية الشاي و أشرب و بدها توقع + +59 +00:04:14,660 --> 00:04:17,760 +مني بدها توقع سخنة بدها تحرقني فبالتالي لأ انا + +60 +00:04:17,760 --> 00:04:21,820 +لازم مافصلي يكون فيها حركة اتمكني من أني أمسك + +61 +00:04:21,820 --> 00:04:26,080 +كباية الشاي اتنولها من الطاولة لحد ما أوصلها لطم + +62 +00:04:26,080 --> 00:04:30,540 +يقاء و أشربو أرجعها هذه لازم يكون في عندى mobility + +63 +00:04:30,540 --> 00:04:34,580 +و لازم يكون كمان as well stability طبعا شكل the + +64 +00:04:34,580 --> 00:04:37,660 +structure of the joint must be able to support a + +65 +00:04:37,660 --> 00:04:41,860 +wide range of function from extreme stability + +66 +00:04:41,860 --> 00:04:46,790 +للمعظم mobilityيعني خلّيني أقول المفاصلة اللي + +67 +00:04:46,790 --> 00:04:51,070 +موجودة في ال suture اللي موجودة في ال skull لازم + +68 +00:04:51,070 --> 00:04:55,510 +تعطينا سؤال لأن مش معقول كل ما نخبط خبطة أو نتعرض + +69 +00:04:55,510 --> 00:04:59,710 +لأي trauma أنه تتحرك مفاصلة الجمجمة لأن هي الجمجمة + +70 +00:04:59,710 --> 00:05:02,950 +وظيفتها حماية ال brain ال brain هو خلّيني أقول ال + +71 +00:05:02,950 --> 00:05:07,110 +monitor تبع الجسم اللي هو اللي بيستقبل و بيرسل كل + +72 +00:05:07,110 --> 00:05:12,920 +الإشارات الحسيةوهو مركز الـ central nervous system + +73 +00:05:12,920 --> 00:05:17,140 +اللي بيتحكم في كل الجسم طبعا وبيعطي أوامره وبيتلقى + +74 +00:05:17,140 --> 00:05:23,560 +من الجسم كله طبعا هتختلف هلقات المفاصل على حسب ال + +75 +00:05:23,560 --> 00:05:28,740 +structure بالنسبة ل stability and mobility طبعا ال + +76 +00:05:28,740 --> 00:05:32,860 +architecture طبعا تركيبة المفاصل كل مفصل تركيبته + +77 +00:05:32,860 --> 00:05:37,240 +هي اللي بتتحكم في كام plan of movement could this + +78 +00:05:37,620 --> 00:05:43,500 +joint play or work or do a function طبعا ال + +79 +00:05:43,500 --> 00:05:49,200 +anatomists اللي هم العلماء العلم التشريح قسموا + +80 +00:05:49,200 --> 00:05:57,260 +المفاصل لعدة أقسام based on the motion زي أخدوا ال + +81 +00:05:57,260 --> 00:06:00,420 +immovable و ال slightly movable و ال freely + +82 +00:06:00,420 --> 00:06:05,330 +movableطب نتعرف على الـ immovable وسموهم sin + +83 +00:06:05,330 --> 00:06:09,430 +arthrosis joints طبعا هي fibrous joints permit + +84 +00:06:09,430 --> 00:06:13,290 +little or no movement of the articulation من + +85 +00:06:13,290 --> 00:06:17,050 +أنواعها الأول هي الـ suture joint اللي هي موجودة + +86 +00:06:17,050 --> 00:06:21,190 +فقط في ال skull أو في الجمجمة اللي هي مسئولة عن + +87 +00:06:21,190 --> 00:06:25,950 +حماية ال brain inside and this joint articulating + +88 +00:06:25,950 --> 00:06:33,080 +bone sheets met closelyand are tightly connected + +89 +00:06:33,080 --> 00:06:38,020 +by fibers that are continuous with the periosteum + +90 +00:06:38,020 --> 00:06:44,780 +يعني هي عبارة عن عملية خيوط من ال fibers مشبوكة مع + +91 +00:06:44,780 --> 00:06:48,740 +ال periosteum مباشرة مباشرة و كأنها عاملة sutures + +92 +00:06:48,740 --> 00:06:53,840 +أو غرز كده زي ما احنا شايفينها بشكل ايه هذا احنا + +93 +00:06:53,840 --> 00:06:58,670 +شايفينها و كأنه هي مكينة و عاملة درزةكدا حوالين ال + +94 +00:06:58,670 --> 00:07:04,230 +boon هذه طبعا تلتئم بتصير ossified في ال adulthood + +95 +00:07:04,230 --> 00:07:09,250 +بتحول ل ossification بطل فيه فتحات او فرقات and + +96 +00:07:09,250 --> 00:07:13,270 +eventually replaced by completely by boon طبعا هذا + +97 +00:07:13,270 --> 00:07:17,570 +الكلام لما بين ولادي ال baby او الطفل بتكون هادي + +98 +00:07:17,570 --> 00:07:21,650 +في مجال لحركة او لنمو بينها او كمان مع فتحات + +99 +00:07:21,650 --> 00:07:25,370 +اليفوفاو اللي بيسموه احنا ال .. ال .. بالعربي و + +100 +00:07:25,370 --> 00:07:29,150 +بالبلدي ان نفوخ الطفل اللي لما بنحسه بنحس كأنه فيه + +101 +00:07:29,150 --> 00:07:33,910 +membrane موجود من عند ال frontal part of the skull + +102 +00:07:33,910 --> 00:07:39,500 +و بيروح لوسط ال skullالشكل الوحيد الموجود هنا بس + +103 +00:07:39,500 --> 00:07:44,480 +في الـ Sintesmosis joint يعني خلّيني أقول هذه + +104 +00:07:44,480 --> 00:07:49,500 +dense fiber tissue بتعمل على ربط two bones + +105 +00:07:49,500 --> 00:07:53,700 +together وطبعا ال movement كتير limited طبعا هذه + +106 +00:07:53,700 --> 00:07:57,100 +بتكون موجودة بين العضمات الطويلة اللي بتكون + +107 +00:07:57,100 --> 00:08:02,040 +متجاورة وكمان في مثل لها تاني الكوراكو أكروميون + +108 +00:08:02,040 --> 00:08:04,980 +اللي هو المفصل بين الكوراكويد بروسوس والأكروميون + +109 +00:08:04,980 --> 00:08:09,480 +إبروسسعساس ما تصيرش انه زواجان لـ movement أثناء + +110 +00:08:09,480 --> 00:08:13,940 +حركة ال shoulder و ال radio ulnar ال mid radio + +111 +00:08:13,940 --> 00:08:17,640 +ulnar joints كمان joint و ال mid tibiofibular + +112 +00:08:17,640 --> 00:08:20,840 +joint و زي ما احنا شايفين و ال inferior + +113 +00:08:20,840 --> 00:08:25,100 +tibiofibular joints وهذه بعض الأمثلة الموجودة زي + +114 +00:08:25,100 --> 00:08:30,730 +ما احنا شايفين اللي تربط عظام الحركة بالبينهابتكون + +115 +00:08:30,730 --> 00:08:34,030 +قليلة يعني احنا بنعرف ان الفيبيا لو تيبيا بتحركوا + +116 +00:08:34,030 --> 00:08:37,430 +مع بعض و كده الكيريديا و لأن الفيبيا هم حركة ال + +117 +00:08:37,430 --> 00:08:41,970 +subination و ال pronation وهذه بتعمل عملية رابط + +118 +00:08:41,970 --> 00:08:47,050 +حتى هدول العضمتين ما ينفكوا عن بعضهمالـ slightly + +119 +00:08:47,050 --> 00:08:51,590 +movable joint اللي بيسموه الـ Amphiarthrosis joint + +120 +00:08:51,590 --> 00:08:55,970 +هذي عبارة عن كارتيليجنس جوانس برمت موشن أو more + +121 +00:08:55,970 --> 00:09:00,850 +motion of the adjacent bone أكتر من السن أرضيال + +122 +00:09:00,850 --> 00:09:06,130 +جوانس طبعا منها السنكندروسيز اللي هي المثل عليها + +123 +00:09:06,710 --> 00:09:12,510 +الـ sternocostal joints وكمان الابيفيزيا الابلاتي + +124 +00:09:12,510 --> 00:09:17,050 +اللى موجود هذا بيكون في العظام حتى بيبدأ بعملية + +125 +00:09:17,050 --> 00:09:22,910 +النمو من خلال عملية نمو و تطور للبون هذا ابتدك + +126 +00:09:22,910 --> 00:09:27,530 +فترة يعني مجال لإن العظام أنها تطول و تواكب اللى + +127 +00:09:27,530 --> 00:09:31,890 +هو نمو و التطور تبع الإنسان وهي عبارة عن thin + +128 +00:09:31,890 --> 00:09:35,170 +layer of hyaline cartilage + +129 +00:09:38,830 --> 00:09:43,710 +أما الـSynthesis Jones فهي زي الـPubic Synthesis + +130 +00:09:43,710 --> 00:09:49,590 +اللي بيربط two pubic bone of the pelvic bone في + +131 +00:09:49,590 --> 00:09:52,890 +هذا الـJones في عندنا ثنبلات أوفيالين يعني زي دسك + +132 +00:09:52,890 --> 00:09:57,310 +كده عامل separated a disc fibro cartilage from the + +133 +00:09:57,310 --> 00:10:01,930 +bone يعني خلّيني أقول العضمتين وفي بينهم كدههو زي + +134 +00:10:01,930 --> 00:10:08,590 +disk كده أو قرص خلينا نسميه بالعربي بيكون موجود + +135 +00:10:08,590 --> 00:10:13,110 +حتى يمنع الاحتكاك ما بين العضمتين وبنفس الوقت يفصل + +136 +00:10:13,110 --> 00:10:18,850 +عضمتين عن بعض و يكون مفصل بيعطينا حركة بسيطة زي ال + +137 +00:10:18,850 --> 00:10:22,150 +disk اللي موجود في ال intervertebral disk و زي + +138 +00:10:22,150 --> 00:10:27,590 +الpupus synthesis اللي هو موضح هنا بالشكل + +139 +00:10:28,520 --> 00:10:33,080 +ال freely movable joints هي ال diaarthrosis or + +140 +00:10:33,080 --> 00:10:38,580 +synovial joints هنا بنتكلم عن معظم مفاصل جسم + +141 +00:10:38,580 --> 00:10:42,420 +الإنسان، مفاصل جسم الإنسان اللي هي بتسمح بال + +142 +00:10:42,420 --> 00:10:46,180 +functional movement، ال locomotion، ال .. كل + +143 +00:10:46,180 --> 00:10:48,320 +الحركات اللي إحنا بنعملها في ال daily activity + +144 +00:10:48,320 --> 00:10:52,520 +بتحتاج منها حركة هرة في المفاصل، هذه ال joints + +145 +00:10:52,880 --> 00:10:57,400 +الحفاظ على الجسد يتم تغطيه بالـ Articular + +146 +00:10:57,400 --> 00:11:01,980 +Cartilage اللي هو الهيالين كارتيلاج والكابسول كمان + +147 +00:11:01,980 --> 00:11:06,420 +بيكون محاطة بالكابسول وفي عندنا Senovial Membrane + +148 +00:11:06,420 --> 00:11:10,600 +وفي عندنا Senovial Fluid inside هذا ال Senovial + +149 +00:11:10,600 --> 00:11:13,740 +Membrane أو Lining بيعطيني ال labrication + +150 +00:11:14,790 --> 00:11:19,510 +السينوفيال الفلود يعني هذا المثل على ال نيجون زي + +151 +00:11:19,510 --> 00:11:22,850 +ما احنا شايفين في عندنا capsule و في عندنا + +152 +00:11:22,850 --> 00:11:25,910 +سينوفيال membrane و في عندنا سينوفيال cavity و + +153 +00:11:25,910 --> 00:11:29,090 +السينوفيال cavity بتكون full of سينوفيال fluid + +154 +00:11:29,090 --> 00:11:31,670 +اللي هو و في عندنا cartilage طبقتين من ال + +155 +00:11:31,670 --> 00:11:35,680 +cartilageطبقتين من ال .. ال cartilage، ال + +156 +00:11:35,680 --> 00:11:41,940 +cartilage حتى يمنع الاحتكاك مع ال .. حتى يمنع + +157 +00:11:41,940 --> 00:11:44,000 +الاحتكاك مع ال two bones + +158 +00:11:48,650 --> 00:11:52,450 +طبعا عندنا many types of synovial joints في عندنا + +159 +00:11:52,450 --> 00:11:55,390 +ال gliding joints في in these joints the + +160 +00:11:55,390 --> 00:12:00,350 +articulating bone surface are nearly flat طبعا ال + +161 +00:12:00,350 --> 00:12:04,510 +gliding في عندنا حركة بس الحركة عن طريق الإزاحة + +162 +00:12:04,510 --> 00:12:09,850 +فقط وهي non axial gliding اللي اللي بتصير طبعا + +163 +00:12:09,850 --> 00:12:13,030 +examples include intermetatarsal و ال + +164 +00:12:13,030 --> 00:12:17,800 +intermetacarpal و ال intertarsal jointsوالـ facet + +165 +00:12:17,800 --> 00:12:21,380 +joints اللي موجودة في ال vertebral هي مثل على ال + +166 +00:12:21,380 --> 00:12:28,440 +gliding joints أما ال hinge joint هي عندنا أكتر + +167 +00:12:28,440 --> 00:12:32,600 +mobility الأهم صار في عندنا في عندنا two surfaces + +168 +00:12:32,600 --> 00:12:38,460 +منها convex و منها concave surface طبعا لازم تكون + +169 +00:12:38,460 --> 00:12:44,060 +two ends of the bone مربطين عن طريق strong كلة ترى + +170 +00:12:44,060 --> 00:12:48,030 +اللي جمت على الجانبين بتعمل علىRestriction للـ + +171 +00:12:48,030 --> 00:12:52,590 +movement في ال planner وهي بتكون شكلها على ال + +172 +00:12:52,590 --> 00:12:58,450 +hinge-like motion ال example هنا ال ulnar humeral + +173 +00:12:58,450 --> 00:13:01,330 +joint اللي هو ال elbow joint و ال interphalangeal + +174 +00:13:01,330 --> 00:13:06,830 +joint أما ال pivot joint فهي حركة ال rotation طبعا + +175 +00:13:06,830 --> 00:13:09,510 +احنا كل واحد من أنواع ال joints هذه هتكون الحركة + +176 +00:13:09,510 --> 00:13:14,710 +فيها limitedفي plan معين يعني كل واحدة منهم بتسمح + +177 +00:13:14,710 --> 00:13:18,230 +الحركة مثلا ال hinge joint بسمح الحركة على في one + +178 +00:13:18,230 --> 00:13:22,290 +plan اللي هو ال societal بplan أما ال pivot joint + +179 +00:13:22,290 --> 00:13:26,490 +فهو بيعطينا بسمحله بحركة ال rotation ال rotation + +180 +00:13:26,490 --> 00:13:30,950 +عادة بتكون في ال horizontal plan بتكون عبارة عن + +181 +00:13:30,950 --> 00:13:34,810 +rotation around and axis طبعا المثل اللي لها + +182 +00:13:34,810 --> 00:13:38,810 +الatlanto axial jointو ال proximal و ال distal + +183 +00:13:38,810 --> 00:13:42,490 +radio ulnar joint اللي بيعملونا حركة ال subination + +184 +00:13:42,490 --> 00:13:46,070 +و ال pronation أما ال Atlanta axial فهي movement + +185 +00:13:46,070 --> 00:13:50,530 +of the neck in right and left rotation وهذا شكل ال + +186 +00:13:50,530 --> 00:13:54,450 +hinge joint زي ما إحنا شايفينه زي هنا عندنا مثل لل + +187 +00:13:54,450 --> 00:13:58,790 +elbow joint أما هنا ال pivot حركة الدوران around + +188 +00:13:58,790 --> 00:14:03,780 +and axisهنا غالبا الحركة بتكون في Sagittal Plan + +189 +00:14:03,780 --> 00:14:10,160 +أما هنا حركة في Transverse Plan أما ال Condyloid + +190 +00:14:10,160 --> 00:14:14,100 +Joint ال Condyloid Joint يعني و كأنه في عيننا two + +191 +00:14:14,100 --> 00:14:18,360 +oval convex and concave surface هدولة بيكونوا + +192 +00:14:18,360 --> 00:14:23,500 +مثبتين فوق بعض Reciprocallyيعني و كأنه زي ما احنا + +193 +00:14:23,500 --> 00:14:27,880 +شايفين بال .. بال .. بالشكل هذا one convex and one + +194 +00:14:27,880 --> 00:14:31,920 +concave surface و بتكون هنا الحركة afflection و + +195 +00:14:31,920 --> 00:14:34,800 +extension في السجنة الإبلان و abduction و + +196 +00:14:34,800 --> 00:14:38,700 +adduction في ال frontal إبلان و ممكن تسمح النائب + +197 +00:14:38,700 --> 00:14:44,560 +حركة من ال circumduction كمان خفيفة خلنا نقول مش + +198 +00:14:44,560 --> 00:14:50,990 +فتري إبلانطبعا هنا ال example هنا بتكون بال meta + +199 +00:14:50,990 --> 00:14:56,010 +-carbo-phalangeal joints الأربعة اللي هو بيبدأ من + +200 +00:14:56,010 --> 00:15:00,490 +ال index ل ال fifth .. ال second ل ال fifth joint + +201 +00:15:00,490 --> 00:15:04,590 +و .. و ال radio-carbal joints اللي هي اللي نسميها + +202 +00:15:04,590 --> 00:15:07,210 +ال wrist joint اللي بيعمللي حركة flexion, + +203 +00:15:07,350 --> 00:15:12,980 +extension, adduction أو radialradio و ulnar + +204 +00:15:12,980 --> 00:15:16,980 +movement هنا ال radial deviation و ال ulnar + +205 +00:15:16,980 --> 00:15:22,220 +deviation أما الصدل joint فهو و كأنه بشبه بحركة + +206 +00:15:22,220 --> 00:15:25,660 +الصدل + +207 +00:15:25,660 --> 00:15:30,190 +اللي هو السرج الحصانكيف يكون الفارس قاعد على سرج + +208 +00:15:30,190 --> 00:15:35,890 +الحصان؟ بيكون عملية التطابق ما بين ال .. زي .. زي + +209 +00:15:35,890 --> 00:15:38,850 +الكرسي اللي بيبقى قاعد عليه الفارس على الحصان اللي + +210 +00:15:38,850 --> 00:15:42,550 +احنا بنسميه سرج الحصان، ال movement دايما بتكون زي + +211 +00:15:42,550 --> 00:15:45,690 +الcondyloid joint لكن بتعطي greater movement زي ال + +212 +00:15:45,690 --> 00:15:50,340 +metacarbophalangeal joint of the thumbأما ال ball + +213 +00:15:50,340 --> 00:15:56,680 +and socket فهو freely movable joints بيعطيني + +214 +00:15:56,680 --> 00:16:00,700 +movement in three planes of movement والمثل عليها + +215 +00:16:00,700 --> 00:16:04,880 +طبعا عادة بيكون هو عندنا convex and concave shape + +216 +00:16:04,880 --> 00:16:10,500 +لكن وكأنها عاملة الكرة و الجراب تبعها بتعطيني + +217 +00:16:10,500 --> 00:16:14,300 +rotation في ال three planes زي ال hip and shoulder + +218 +00:16:14,300 --> 00:16:19,670 +joint طبعا ال synaphear joints veryبتختلف كثيرًا + +219 +00:16:19,670 --> 00:16:25,050 +في قدرة حركة المحركة كما شهدت في الفيجورية التي + +220 +00:16:25,050 --> 00:16:30,530 +سنشاهدها إنهم عامًا مستخدمين بالنسبة للعدد من + +221 +00:16:30,530 --> 00:16:34,710 +اكسسات التحول طبعًا في عندنا اكسس واحد أو اكسس + +222 +00:16:34,710 --> 00:16:39,190 +اثنان او اكسس ثلاث فالاكسس واحد يسمى uniaxialوالـ + +223 +00:16:39,190 --> 00:16:43,170 +two axis بيسمى biaxial والـ three axis بيسمى + +224 +00:16:43,170 --> 00:16:51,510 +triaxial وهنا الفيجر هذا اللي بيوضحلي المفاصل بشكل + +225 +00:16:51,510 --> 00:16:55,490 +عام هذا الكندلايد اللي بيعطيني ال two axisهنا ال + +226 +00:16:55,490 --> 00:16:58,770 +ball and socket بيعطيني three axis إن ال gliding + +227 +00:16:58,770 --> 00:17:03,270 +joint ال movement non axial movement فقط هي عملية + +228 +00:17:03,270 --> 00:17:06,970 +gliding وهنا ال pivot اللي بيعطيني حركة ال + +229 +00:17:06,970 --> 00:17:11,010 +rotation وهنا الصدل اللي هو ال metacarpophalangeal + +230 +00:17:11,010 --> 00:17:16,970 +joint of the thumb اللي بيعطيني حركة ب two plants، + +231 +00:17:16,970 --> 00:17:19,690 +deflection, extension, abduction, adduction وكمان + +232 +00:17:19,690 --> 00:17:21,670 +بيعطيني حركة بنسميها ال opposition + +233 +00:17:24,110 --> 00:17:28,070 +طبعا الـ few joints where only limited motion is + +234 +00:17:28,070 --> 00:17:32,530 +permitted in any direction are termed non-axial و + +235 +00:17:32,530 --> 00:17:35,890 +الـ joint motion capability also sometimes + +236 +00:17:35,890 --> 00:17:39,470 +described in terms of degree of freedom فلما نتكلم + +237 +00:17:39,470 --> 00:17:42,290 +عن movement in one plan بنسميها one degree of + +238 +00:17:42,290 --> 00:17:46,740 +freedom اللي هي الـ uniaxialو لو كانت ال two plan + +239 +00:17:46,740 --> 00:17:51,080 +بتسمى bi-axial بتسمى two degree of freedom و كذلك + +240 +00:17:51,080 --> 00:17:55,040 +ال tri-axial joint بتسمى three degree of freedom + +241 +00:17:55,040 --> 00:17:59,640 +طبعا هاي مصميات مختلفة للمفاصل ممكن نقرأها في عدة + +242 +00:17:59,640 --> 00:18:03,440 +مراجع حتى نكون احنا عارفينها طبعا ال synovial + +243 +00:18:03,440 --> 00:18:07,240 +structure دائما بيكون في عنده associated with the + +244 +00:18:07,240 --> 00:18:11,550 +diarthroأرثروديال جونس هي في عندنا البرصة + +245 +00:18:11,550 --> 00:18:14,750 +والتندونشيت ايش وظيفة البرصة والتندونشيت تعمل + +246 +00:18:14,750 --> 00:18:19,650 +عملية facilitation لالمovement و حماية للتندون او + +247 +00:18:19,650 --> 00:18:22,710 +لل structure اللي هي بتكون موجودة يعني موجودة + +248 +00:18:22,710 --> 00:18:29,390 +البرصة تقريبا هي عبارة عن small capsules موجودة + +249 +00:18:29,390 --> 00:18:34,530 +خلّيني أقول مخدة موجودة within the synovial + +250 +00:18:34,530 --> 00:18:39,190 +membraneو بتكون موجودة فيها synovial fluid وظيفتها + +251 +00:18:39,190 --> 00:18:42,990 +تعمل مخدة separating ال bone عن ال bone او ال + +252 +00:18:42,990 --> 00:18:47,190 +tendon عن ال bone حتى تمنع عملية الاحتكاك اللي + +253 +00:18:47,190 --> 00:18:51,290 +هتكون heart from the structure اللي بيمر من خلاله + +254 +00:18:51,290 --> 00:18:54,090 +يعني احنا نتخيل انه في عندنا tendon هو قاعد طول ما + +255 +00:18:54,090 --> 00:18:57,990 +هو بنعمل حركة هو بيحق في العضم تخيلوا انه نمسك حبل + +256 +00:18:57,990 --> 00:19:05,070 +احنا و نضلنا انحت فيفي عضمة او في لوح خشبي اش بصير + +257 +00:19:05,070 --> 00:19:08,790 +فيها بتنقطع اما لو احنا حطينا حماية حطينا نخدة و + +258 +00:19:08,790 --> 00:19:12,970 +كنا بنمرر هذا اللي مش ممكن انه ينطق ال most bursa + +259 +00:19:12,970 --> 00:19:16,870 +separate tendon from bone reducing the friction of + +260 +00:19:16,870 --> 00:19:21,210 +the tendon during joint motion طبعا some bursaمثل + +261 +00:19:21,210 --> 00:19:25,470 +الاوليكرانون البرصة الموجودة تحت الاوليكرانون من + +262 +00:19:25,470 --> 00:19:30,130 +البون بتفصل البون عن ال skin عشان مايكونش ال skin + +263 +00:19:30,130 --> 00:19:36,290 +مباشرة على البون اما ال tendon sheets فهو عبارة عن + +264 +00:19:36,290 --> 00:19:40,870 +غلاف حماية زي الغلاف اللى بنحطه على اي اشى احنا + +265 +00:19:40,870 --> 00:19:44,530 +حتى نحميه عبارة عن double layer synovial structure + +266 +00:19:44,530 --> 00:19:48,100 +that surround ال tendonpositioned in clothes + +267 +00:19:48,100 --> 00:19:51,560 +associated with moon، ال tendon sheet هذا ال sheet + +268 +00:19:51,560 --> 00:19:55,260 +اللي بيعمل حماية لل tendon لما بيكون بيمر على + +269 +00:19:55,260 --> 00:20:01,060 +العضم العضل، many of the long muscle tendon اللي + +270 +00:20:01,060 --> 00:20:04,880 +بتعدي على ال wrist و ال finger بتكون protected by + +271 +00:20:04,880 --> 00:20:09,140 +tendon sheets حتى تمنع الاعديكاالروح لموضوع مهم + +272 +00:20:09,140 --> 00:20:11,780 +related لكلام اللي احنا بنحكي اللي هي ال joint + +273 +00:20:11,780 --> 00:20:16,080 +stability، طبعا the stability of an articulation + +274 +00:20:16,080 --> 00:20:21,860 +is its ability to resist dislocation، إيش يعني؟ + +275 +00:20:21,860 --> 00:20:25,620 +أنا بتكلم عن joint، ال joint هذا يظل في مكانه، + +276 +00:20:25,620 --> 00:20:29,900 +ماينفصل أو ماينزح أو ماينسفر، في لا dislocation + +277 +00:20:29,900 --> 00:20:33,900 +ولا subluxation، يعني لابد ينخلع من مكانهواللي + +278 +00:20:33,900 --> 00:20:37,580 +بديه كمان أنه يتحرك من مكانه بحيث ما يعمليش ألم + +279 +00:20:37,580 --> 00:20:43,440 +شديد على المفسد especially it is the ability to + +280 +00:20:43,440 --> 00:20:46,740 +resist the displacement of one bone end with + +281 +00:20:46,740 --> 00:20:51,860 +respect to another وكمان to prevent injury to the + +282 +00:20:51,860 --> 00:20:52,320 +ligament + +283 +00:21:00,060 --> 00:21:04,400 +أول حاجة الـ shape of the articulating bone + +284 +00:21:04,400 --> 00:21:10,120 +surface طبعا مهم كتير في ال mechanical joints ال + +285 +00:21:10,120 --> 00:21:14,960 +articulating part are exact opposition in shape so + +286 +00:21:14,960 --> 00:21:18,480 +that fit tightly together يعني انه و كأنه في ان + +287 +00:21:18,480 --> 00:21:23,290 +السطحوالسطح كونكاب ومتلبسين في بعض وزي ما شايفين + +288 +00:21:23,290 --> 00:21:26,710 +هنا شكل الهن الجايند بده يكون فيه تطابق وكذلك + +289 +00:21:26,710 --> 00:21:30,130 +الصدر الجاند و ال ball and socket جاند لكن في + +290 +00:21:30,130 --> 00:21:33,790 +عوامل مختلفة بتأثر في ال human body the + +291 +00:21:33,790 --> 00:21:35,950 +articulating end of the bone + +292 +00:21:44,540 --> 00:21:50,240 +معظم المجلدات لديها مجلدات متصرفة ومتطابقين + +293 +00:21:50,240 --> 00:21:54,180 +ومتطابقين ومتطابقين + +294 +00:21:54,340 --> 00:21:59,000 +نتكلم عن مثل المفصل الشوردر، الشوردر، لأ والله ال + +295 +00:21:59,000 --> 00:22:03,880 +head of the humerus مش متطابقة تماما مع ال + +296 +00:22:03,880 --> 00:22:06,820 +leganoid cavity عشان فيه حاجة اسمها labrum + +297 +00:22:06,820 --> 00:22:10,680 +acetaglialae، هذه بتزود ال congruence تبع الجنازة + +298 +00:22:10,680 --> 00:22:14,260 +and there is typical one position of best fit in + +299 +00:22:14,260 --> 00:22:17,580 +which the area of contact is maximumوهذا ال + +300 +00:22:17,580 --> 00:22:20,780 +position اللي احنا عادة بنسميه closed back + +301 +00:22:20,780 --> 00:22:24,900 +position هي ال position اللي بكون فيه المفصل أكتر + +302 +00:22:24,900 --> 00:22:28,360 +إشي في عندنا greatest stability موجودة فيه اللي + +303 +00:22:28,360 --> 00:22:33,340 +بكون أكتر إشي موجود في المفصل في حالة stability + +304 +00:22:33,340 --> 00:22:40,830 +وفي تماث أو في contact بين ال two ends of boneطبعا + +305 +00:22:40,830 --> 00:22:44,830 +أي حركة بتكون يعني بعيدة عن ال closed back + +306 +00:22:44,830 --> 00:22:48,990 +فبنسميها ال lose back position في هذه الحركة بتكون + +307 +00:22:48,990 --> 00:23:01,150 +أقل ال contact بين ال two bone endsو أي + +308 +00:23:01,150 --> 00:23:05,450 +حركة تانية في المفصل يعني زي ما احنا بنتكلم عن + +309 +00:23:05,450 --> 00:23:10,790 +المفاصل في هذه الحركة بنقدر احنا نعملها لإنه هنا + +310 +00:23:10,790 --> 00:23:15,930 +المفصل كتير stable some articulating surfaces are + +311 +00:23:15,930 --> 00:23:20,970 +shaped so that in both close and in back position + +312 +00:23:21,380 --> 00:23:25,420 +there is either a large or small amount of contact + +313 +00:23:25,420 --> 00:23:29,540 +area and consequently more or less stability طبعا + +314 +00:23:29,540 --> 00:23:34,000 +هذا يعني احنا بنعرف ان المفاصل في بعض المفاصل نقول + +315 +00:23:34,000 --> 00:23:37,880 +والله هذا relaxing position يعني ان ال ligaments + +316 +00:23:37,880 --> 00:23:41,800 +بتكون كتير رافية لأ والله هذا هنا بنقدر نعمل حركة + +317 +00:23:41,800 --> 00:23:45,290 +او مابنقدرش نعمل حركةطبعا هنا ال acetabulum + +318 +00:23:45,290 --> 00:23:49,170 +provide a relatively deep socket for the head طبعا + +319 +00:23:49,170 --> 00:23:53,930 +موجودة ال acetabulum في جراب كامل ومحاطة كل ال + +320 +00:23:53,930 --> 00:23:58,230 +head of a female محاطة بال acetabulum ودائما في + +321 +00:23:58,230 --> 00:24:02,350 +عنا large amount of contact عشان هيك احنا بنسمي ال + +322 +00:24:02,740 --> 00:24:05,780 +الـ hip joint is a stable joint أما الـ shoulder + +323 +00:24:05,780 --> 00:24:09,400 +لأ في عندنا small glenoid فصة و في نفس الوقت في ال + +324 +00:24:09,400 --> 00:24:12,520 +vertical diameter لو احنا قصنا في عندنا + +325 +00:24:12,520 --> 00:24:15,500 +approximately 75% of the vertical diameter في + +326 +00:24:15,500 --> 00:24:18,600 +contact of the humeral head and horizontal + +327 +00:24:18,600 --> 00:24:23,080 +diameter بس في عندنا 60%مقارنة بمقارنة مقارنة + +328 +00:24:23,080 --> 00:24:28,620 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +329 +00:24:28,620 --> 00:24:36,840 +مقارنة مقارنة + +330 +00:24:36,860 --> 00:24:41,680 +بالنسبة للمشكلة المرتبطة في المجلد نحن نعرف أن + +331 +00:24:41,680 --> 00:24:45,280 +المجلد هو أكتر مجلد موبايل وكذلك أكتر مجلد مستقل + +332 +00:24:45,280 --> 00:24:50,240 +لأنه لا يوجد مقارنة حقيقية بين رئيس الهيوميرس + +333 +00:24:50,240 --> 00:24:55,100 +والأساترولاب إصلاحات أناطمة للتغيير في شكل ومعمومة + +334 +00:24:55,100 --> 00:24:58,900 +مجلد مجلد موبايل ومعمومة مجلد موبايل ومعمومة مجلد + +335 +00:25:01,800 --> 00:25:05,360 +Some people have joints that are more or less + +336 +00:25:05,360 --> 00:25:08,620 +stable than average، خلّينا نقول إن الناس اللي في + +337 +00:25:08,620 --> 00:25:11,880 +عندهم flexibility هدول هنتكلم عليهم لاحقا، و في + +338 +00:25:11,880 --> 00:25:14,920 +ناس بنقول إن هم يعني ع السريع ممكن يصير في عنده + +339 +00:25:14,920 --> 00:25:18,420 +زوغان في المفصل، ع السريع ممكن إنه يصير في عنده + +340 +00:25:18,420 --> 00:25:22,300 +خلق مثلا في المفصل، وهكذا ال variations بتكون + +341 +00:25:22,300 --> 00:25:26,650 +individualregion of the ligament and the muscle + +342 +00:25:26,650 --> 00:25:31,170 +طبعا هذه من العوامل ال ligament و ال muscle و ال + +343 +00:25:31,170 --> 00:25:33,790 +muscle tendon affect relatively the stability of + +344 +00:25:33,790 --> 00:25:37,070 +the joint طبعا ال knee joint احنا بنتعرف انه ال + +345 +00:25:37,070 --> 00:25:41,790 +shoulder joint ال bone بيكون ال configuration is + +346 +00:25:41,790 --> 00:25:46,970 +not particularly stable ليش؟ لأنه في حجم العضم + +347 +00:25:46,970 --> 00:25:51,820 +اللي موجود مختلف ما بينالـ two ends of the bone + +348 +00:25:51,820 --> 00:25:55,720 +يعني مثلا الـ humerus الـ head تبعتها أكبر من الـ + +349 +00:25:55,720 --> 00:26:00,080 +acetabulum ال femoral condyle أكتر من ال plateau + +350 +00:26:00,080 --> 00:26:05,080 +تبعت التيبيا طبعا تكون في عنا دائما ليجامن و + +351 +00:26:05,080 --> 00:26:08,700 +muscle contribute in the stability وهي اللي بتساعد + +352 +00:26:08,700 --> 00:26:12,200 +على ال holding the articular bones in together + +353 +00:26:12,200 --> 00:26:16,360 +طبعا إذا كانت هذه ال tissue weak كمن نتيجة disuse + +354 +00:26:16,360 --> 00:26:20,750 +أو laxityfrom being overstretched طبعا بتقل ال + +355 +00:26:20,750 --> 00:26:24,370 +stability و بصير في reduction لل stability و بصير + +356 +00:26:24,370 --> 00:26:27,870 +في عندى مشكلة ممكن يكون المفصل معرض لإنه يصير في + +357 +00:26:27,870 --> 00:26:31,390 +dislocation او subluxation طبعا ال strong ligament + +358 +00:26:31,390 --> 00:26:34,970 +ال muscle دائما بيزود ال stability عشانك احنا حتى + +359 +00:26:34,970 --> 00:26:38,410 +لو يعني في حياتنا العملية لو صار فينا اي مشكلة في + +360 +00:26:38,410 --> 00:26:41,270 +ال ligament بنعمل على تقوية العضلات المحيطة + +361 +00:26:41,270 --> 00:26:46,220 +بالمفصل حتى انهوض الخلل الحاصل في ال ligamentعن + +362 +00:26:46,220 --> 00:26:50,660 +طريق ال stability of the muscle طبعا هنا ال + +363 +00:26:50,660 --> 00:26:53,200 +stretching of the quadriceps and the hamstring + +364 +00:26:53,200 --> 00:26:56,860 +group ده عادة هو اللي بيساعدني لما بيكونوا stable + +365 +00:26:56,860 --> 00:27:00,980 +هدولة to muscle بيساعد على ال stability of the + +366 +00:27:00,980 --> 00:27:05,340 +knee و طبعا احنا هنشوف ال complexity تبع ال knee + +367 +00:27:05,340 --> 00:27:08,220 +joint في ال illustration زي ما انتوا شايفين ال + +368 +00:27:08,220 --> 00:27:11,380 +knee joint بتمتع بعدد كبير من ال ligaments و ال + +369 +00:27:11,380 --> 00:27:14,380 +tendons اللي بتمرعليه في عنا ال lateral collateral + +370 +00:27:14,380 --> 00:27:18,580 +ligament و ال media collateral ligament زي ما احنا + +371 +00:27:18,580 --> 00:27:21,840 +شايفين و في عنا media meniscus و في عنا lateral + +372 +00:27:21,840 --> 00:27:25,560 +meniscus هدولة بيزودوا ال congruent سبعت ال joints + +373 +00:27:25,560 --> 00:27:28,600 +و في عنا ال anterior و ال posterior الجرافيات + +374 +00:27:28,600 --> 00:27:32,740 +ligament اللي بيزودوا ال stabilityTowards the + +375 +00:27:32,740 --> 00:27:35,800 +anterior and posterior drawer of the knee وفي + +376 +00:27:35,800 --> 00:27:40,160 +عندنا التندبات الليه و هذه كلها المنظومة الكبيرة + +377 +00:27:40,160 --> 00:27:44,740 +بتعمل على حماية مصل النيه من أن يصير فيه أي + +378 +00:27:44,740 --> 00:27:49,240 +displacement أو distraction طبعا كمان ال angle of + +379 +00:27:49,240 --> 00:27:54,670 +attachment of the most tendonto the bone بساعد + +380 +00:27:54,670 --> 00:27:58,690 +عادة ال arrangement هذه على إن العضلة لو عملت أي + +381 +00:27:58,690 --> 00:28:01,630 +tension when the muscle exert tension ال + +382 +00:28:01,630 --> 00:28:04,470 +articulation end of the bone and the joint across + +383 +00:28:04,470 --> 00:28:08,910 +are pulled closer together حتى تتزود ل stability + +384 +00:28:08,910 --> 00:28:12,260 +to enhance stability of the jointفي هذه الحالة + +385 +00:28:12,260 --> 00:28:15,400 +usually found when the muscle on the opposite side + +386 +00:28:15,400 --> 00:28:18,180 +of the joint producing simultaneously في حاجة اسمة + +387 +00:28:18,180 --> 00:28:22,320 +synergy بين العضلات هذه بتشغل فتانية بتشغل بتساعد + +388 +00:28:22,320 --> 00:28:27,500 +على أنها تحمي وتعمل حماية حول المفاصل المفاصل لما + +389 +00:28:27,500 --> 00:28:30,600 +تكون fatigue هذا بيأثر على ال joint stability و ال + +390 +00:28:30,600 --> 00:28:34,040 +injuryعلى طول بتحصل فبصير عندي .. اذا في عندي + +391 +00:28:34,040 --> 00:28:37,380 +fatigability في ال muscle فاهنا بيكون الحماية على + +392 +00:28:37,380 --> 00:28:42,080 +المفصل اقل فيبقى المفصل بيكون less stable طبعا اذا + +393 +00:28:42,080 --> 00:28:46,940 +صار في عندنا crushier ligament rupture بيكون لما + +394 +00:28:46,940 --> 00:28:50,000 +ال tension في ال fatigue muscle surrounding دنيه + +395 +00:28:50,000 --> 00:28:53,560 +inadequate to protect ال crushier ligament from + +396 +00:28:53,560 --> 00:28:57,760 +being stretched beyond their elastic limitطبعا في + +397 +00:28:57,760 --> 00:29:00,120 +عندنا other connective tissues زي حاجة اسمها + +398 +00:29:00,120 --> 00:29:03,040 +الفاشيا الفاشيا surrounding the muscle وقولنا في + +399 +00:29:03,040 --> 00:29:09,740 +عندنا شيط دايما بحيط العضلات طبعا ال bundles of + +400 +00:29:09,740 --> 00:29:12,600 +muscle fibers within the muscle provide protection + +401 +00:29:12,600 --> 00:29:16,140 +and support وهذا الشيء منطقي ال particularly + +402 +00:29:16,140 --> 00:29:17,860 +strong permanent + +403 +00:29:22,230 --> 00:29:25,830 +الفاشيا زي الـ ileotapial band اللي موجودة في الـ + +404 +00:29:25,830 --> 00:29:29,410 +lateral aspect of the knee هذه بتعمل على زيادة ال + +405 +00:29:29,410 --> 00:29:34,310 +stability of the knee joint الفاشيا فاشيا and the + +406 +00:29:34,310 --> 00:29:39,070 +skin on the exterior of the body and other tissue + +407 +00:29:39,430 --> 00:29:42,670 +that contribute and show integrity طبعا احنا الجسم + +408 +00:29:42,670 --> 00:29:46,550 +قلنا هو محق بالفاشية وبعد الفاشية يعني احنا بنتكلم + +409 +00:29:46,550 --> 00:29:51,630 +عن muscles ال muscle هذه sorry بنتكلم عن الجهاز + +410 +00:29:51,630 --> 00:29:57,040 +الهيكلي اللي هو بيكون فيهالعظام المرتبطة مع بعض عن + +411 +00:29:57,040 --> 00:30:00,320 +طريق articulations اللي في ال articulations هذه + +412 +00:30:00,320 --> 00:30:03,320 +فيها أربطة و connective tissue كمان المصل بتكون + +413 +00:30:03,320 --> 00:30:06,620 +محيط هذا العظيم عشان تزود ال stability تبعته و + +414 +00:30:06,620 --> 00:30:09,780 +كمان في عيناه فاشية و في عيناه skin هذه كلها + +415 +00:30:09,780 --> 00:30:13,360 +منظومة ربنا سبحانه وتعالى خلقها حتى تساعد على ال + +416 +00:30:13,360 --> 00:30:16,580 +stability و تزود ال stabilityوطبعا هنا بنوصل + +417 +00:30:16,580 --> 00:30:20,600 +لنهاية محاضرتنا لليوم زي ما احنا بس بنوضح في + +418 +00:30:20,600 --> 00:30:24,520 +نهايتها الاليوتيبيا ال tract اللي بتيجي من ال hip + +419 +00:30:24,520 --> 00:30:29,940 +لأسفل knee حتى تزود ال stability تبع ال lateral + +420 +00:30:29,940 --> 00:30:35,320 +part of the knee joint بهك احنا بنكون وصلنا لنهاية + +421 +00:30:35,320 --> 00:30:39,900 +محاضرتنا لليوم نراكم ان شاء الله في محاضرة قادمة + +422 +00:30:39,900 --> 00:30:43,780 +بإذن الله هنتكلم فيها عن ال joint flexibility + diff --git a/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/hkf-8Ronmcc_raw.json b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/hkf-8Ronmcc_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..62021e626b310c43ffd9a531434ae67a6b02bbd7 --- /dev/null +++ b/PL9fwy3NUQKwbSzKa8RyaijzcvmsYocon2/hkf-8Ronmcc_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2460, "start": 0.98, "end": 24.6, "text": "بسم الله الرحمن الرحيم والصلاة والسلام على سيدنا محمد سيد البرسلين وعلى أهله وصحبه أجمعين نكمل في مساق ال bio-mechanic of tendon and ligament وحنتعرف اليوم من خلال محاضرتنا ان شاء الله على ال mechanical أو ال bio-mechanical properties of ligament and tendon", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 16070, 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of stretching ان احنا بنعرف ان الحرارة بتعمل ارتخاء و هذا الكلام مثلنا كتير في بداية محاضراتنا انه دائما الحرارة بس الحرارة العالية لأ و الحرارة", "tokens": [9566, 3555, 3615, 995, 34105, 264, 1802, 295, 41234, 4188, 322, 12070, 40651, 1088, 2423, 4001, 4188, 34105, 8032, 29399, 4117, 19528, 18871, 11331, 26108, 2655, 9957, 13672, 1829, 39896, 2423, 3314, 295, 19632, 4032, 2423, 4292, 295, 264, 3877, 412, 264, 565, 295, 19632, 16472, 1975, 5016, 8315, 44945, 3615, 28480, 16472, 21542, 2288, 9640, 3660, 39894, 25957, 1211, 1975, 43500, 9778, 16606, 4032, 23758, 2423, 28820, 10943, 50113, 1211, 8315, 9122, 2655, 13546, 8978, 4724, 28259, 10632, 3714, 5016, 46958, 2288, 9307, 8315, 16472, 3224, 11778, 16373, 15042, 21542, 2288, 9640, 3660, 4724, 3794, 21542, 2288, 9640, 3660, 18863, 6027, 10632, 5296, 10721, 4032, 21542, 2288, 9640, 3660], "avg_logprob": -0.1648367095637966, "compression_ratio": 1.7851851851851852, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1372.8, 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2025.95, "word": " ما", "probability": 0.80322265625}, {"start": 2025.95, "end": 2026.21, "word": " في", "probability": 0.76171875}, {"start": 2026.21, "end": 2026.57, "word": " عندي", "probability": 0.929443359375}, {"start": 2026.57, "end": 2026.91, "word": " فترة", "probability": 0.99658203125}, {"start": 2026.91, "end": 2027.09, "word": " من", "probability": 0.99560546875}, {"start": 2027.09, "end": 2027.25, "word": " ال", "probability": 0.91357421875}, {"start": 2027.25, "end": 2028.09, "word": " immobility", "probability": 0.9054361979166666}], "temperature": 1.0}, {"id": 91, "seek": 205594, "start": 2028.66, "end": 2055.94, "text": "هذا الأفكت يؤثر على الـ hearing كمان على الـ normal joint structure و يprovide effective and safe rehabilitation طبعا المعرفة في هذا الاشي بتساعدني على انا اعرف كيف انا بدي اشتغل مع هذا المرض و على ايش انا بدي اركز طب ال joint immobilization ايش بتعمل؟ Reduce the tensile forces normally applied to the tendon and ligament during joint movement", 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00:00:04,660 +باسم الله الرحمن الرحيم والصلاة والسلام على سيدنا + +2 +00:00:04,660 --> 00:00:10,180 +محمد سيد المرسلين وعلى آله وصحبه أجمعين، طبعاً بنرحب + +3 +00:00:10,180 --> 00:00:13,800 +فيكم، طول من طلبات الأعزاء في بداية الفصل الأول + +4 +00:00:13,800 --> 00:00:19,700 +لعام 2021، وبتمنى طبعاً السلامة للجميع، وبتمنى أنتم + +5 +00:00:19,700 --> 00:00:24,150 +تكونوا أنتم وأهليكم بإذن الله بألف صحة وعافية، وربنا + +6 +00:00:24,150 --> 00:00:28,370 +يبعد عنكم قوة الوباء، وقبلها إن شاء الله رب العالمين + +7 +00:00:28,370 --> 00:00:32,930 +محاضرتنا اليوم هنتكلم عن الـ biomechanics of being + +8 +00:00:32,930 --> 00:00:36,570 +of bones كمان للمحاضرات السابقة في الـ + +9 +00:00:36,570 --> 00:00:40,560 +biomechanics، احنا الحقيقة أجرينا بعض المواضيع للفصل + +10 +00:00:40,560 --> 00:00:45,440 +هذا على أمل أن يكون إن شاء الله التعليم مجاهياً + +11 +00:00:45,440 --> 00:00:50,120 +ومتقدماً في الجامعة، من الممكن أن تجرى نهاية الفصل + +12 +00:00:50,120 --> 00:00:57,400 +لو عسى أن نكون في عودة على الجامعة، هنستكمل معكم + +13 +00:00:57,400 --> 00:01:00,000 +الـ biomechanics of bone, biomechanics of muscle, + +14 +00:01:00,160 --> 00:01:03,060 +biomechanics of cartilage, biomechanics of + +15 +00:01:03,060 --> 00:01:07,490 +ligament and joints، وآخر شيء هيكون معنا الـ gait + +16 +00:01:07,490 --> 00:01:10,690 +والـ gait analysis والـ gait deviation إن شاء الله + +17 +00:01:10,690 --> 00:01:16,090 +في نهاية الفصل، طبعاً احنا اليوم هنتكلم عن الـ + +18 +00:01:16,090 --> 00:01:22,170 +biomechanics of bone، وتركيبة الـ bone في البداية هي + +19 +00:01:22,170 --> 00:01:27,990 +عبارة عن نوعين، Organic and Inorganic Materials. + +20 +00:01:27,990 --> 00:01:32,890 +طبعاً الـ Inorganic Material بتشكل 45%، والـ Organic + +21 +00:01:32,890 --> 00:01:37,910 +Matrix بتشكل 30%، وبنعرف أن المكون الأساسي لمكونات + +22 +00:01:37,910 --> 00:01:44,270 +جسم الإنسان هو الـ Water، فبتشكل 25% من الـ Total + +23 +00:01:47,610 --> 00:01:52,730 +هنقول Consistency of Bone، الـ Inorganic Materials + +24 +00:01:52,730 --> 00:01:54,810 +زي الـ Calcium والـ Phosphate، واحنا الـ + +25 +00:01:54,810 --> 00:01:59,890 +Phosphate اللي هو بيشكل تقريباً من 60 لـ 70% من الـ + +26 +00:01:59,890 --> 00:02:03,810 +dry weight of the bone، هو اللي بيشكل بيعطينا الـ + +27 +00:02:03,810 --> 00:02:06,830 +rigidity والـ hardness، احنا بتعرف إن الـ bone إن + +28 +00:02:06,830 --> 00:02:09,440 +احنا نتعرف على وظيفتها، فهي وظيفتها الـ support الـ + +29 +00:02:09,440 --> 00:02:12,960 +support يعني لازم تكون rigid and hard، بخلاف الـ + +30 +00:02:12,960 --> 00:02:18,100 +muscles اللي بتكون فيها مرونة عشان تعمل الـ action + +31 +00:02:18,100 --> 00:02:23,240 +طبعاً كمان الـ bone serve as receiver of essential + +32 +00:02:23,240 --> 00:02:28,320 +minerals of the body، بالذات الكالسيوم، هي كأنها + +33 +00:02:28,320 --> 00:02:33,470 +بتعمل مخزون للكالسيوم في جسم الإنسان، الـ Organic + +34 +00:02:33,470 --> 00:02:37,730 +Substance زي الـ Protein اللي بتكون من الـ + +35 +00:02:37,730 --> 00:02:41,450 +Collagen، هو بيعطينا الـ bone Elasticity وFlexibility + +36 +00:02:41,450 --> 00:02:45,430 +معناه إن الـ bone مش سهلة إن تتكسر لو ما كانش فيها + +37 +00:02:45,430 --> 00:02:48,690 +Collagen، ولو ما كانش فيها جزء من الـ Elasticity + +38 +00:02:48,690 --> 00:02:53,030 +فبكون سهل تكسرها، يعني احنا بنعرف كل ما زادت الـ + +39 +00:02:53,030 --> 00:02:58,960 +Elasticity في أي جسم، في أي مادة، بتساعد على، خلّينا + +40 +00:02:58,960 --> 00:03:07,660 +نقول عدم تكسّرها أو الإجهاد فيها، طبعاً الـ Bones اللي + +41 +00:03:07,660 --> 00:03:10,920 +Bone إلها two خلّينا نقول functions منها mechanical + +42 +00:03:10,920 --> 00:03:13,540 +function ومنها biological function، الـ mechanical + +43 +00:03:13,540 --> 00:03:17,520 +function اللي هي الحركية أو اللي بتعتمد على اللي + +44 +00:03:17,520 --> 00:03:22,140 +بتساعدنا على الحركة زي الـ support أو التبديل لإن + +45 +00:03:22,140 --> 00:03:26,540 +احنا بيعرفوا، احنا إن كل الأجزاء اللي قسم مركبة على + +46 +00:03:26,540 --> 00:03:27,200 +الهيكل العظمي + +47 +00:03:37,200 --> 00:03:42,980 +بنقف ونقعد ونتحرك على الـ skeletal system بمساعدة + +48 +00:03:42,980 --> 00:03:45,380 +الـ muscular system، تعمل protection على الـ + +49 +00:03:45,380 --> 00:03:46,240 +internal organs + +50 +00:03:51,390 --> 00:03:54,750 +أو عضلات أعضاء جسم الإنسان مثل الـ Brain، نطلع الـ + +51 +00:03:54,750 --> 00:03:58,930 +Vertebral column هو بيعملنا حماية للـ spinal cord + +52 +00:03:58,930 --> 00:04:03,070 +نطلع الـ rib cage بيعملنا حماية للقلب والرئتين + +53 +00:04:03,070 --> 00:04:08,330 +الحوض بيعملنا حماية + +54 +00:04:08,330 --> 00:04:13,270 +كبيرة على منطقة الجنين، وتعدل لنا الـ organs، فهذا + +55 +00:04:13,270 --> 00:04:18,790 +الحماية بتساعد على الحفاظ على الأجزاء اللي داخلها + +56 +00:04:18,790 --> 00:04:20,630 +لأن كلها بيبقوا فيها Vital + +57 +00:04:31,870 --> 00:04:39,470 +العضلات بتعمل عضلات على العظام لتشكل الروافع + +58 +00:04:39,470 --> 00:04:44,530 +العظام عبارة عن الروافع اللي بتعمل عليها العضلات + +59 +00:04:47,870 --> 00:04:51,470 +هي تعملوا application في حتى كيف فهمنا وإدراكنا + +60 +00:04:51,470 --> 00:04:58,070 +لإيش وظائف الـ musculators كمان بساعدني على الـ + +61 +00:04:58,070 --> 00:05:02,090 +facilitation للـ muscle action وبساعدني على الـ + +62 +00:05:02,090 --> 00:05:05,410 +movement لإن احنا بنقدر نتحرك عن طريق الـ muscle + +63 +00:05:05,410 --> 00:05:11,190 +action اللي هو بيقوم بتجربة بيتحرك العظام هذه اللي + +64 +00:05:11,190 --> 00:05:12,290 +تعملها الـ movement + +65 +00:05:16,300 --> 00:05:21,580 +كمان الـ biological function بتساعد وجود الحمض في + +66 +00:05:21,580 --> 00:05:25,720 +حاجة اسمها Hematopoiesis + +67 +00:05:25,720 --> 00:05:29,320 +FDA اللي هي مصنع لـ blood cells + +68 +00:05:40,490 --> 00:05:46,290 +الأولى هي الـ Factories of Blood Cell Formation، و + +69 +00:05:46,290 --> 00:05:51,710 +أيضاً Storage لـ Metabolites أو للمعادن اللي + +70 +00:05:51,710 --> 00:05:53,710 +بتساعدني في الـ Metabolic Interaction + +71 +00:05:56,530 --> 00:05:59,690 +طبعاً هي highly vascularized، لإيش؟ احنا بنتلاحظ + +72 +00:05:59,690 --> 00:06:04,850 +إنه لما تنتكس العظام ما بتاخد وقت لإنها ت... تصير + +73 +00:06:04,850 --> 00:06:07,710 +فيها healing لكن already بتصير فيها healing بعكس + +74 +00:06:07,710 --> 00:06:10,010 +مثلاً الكارت اللي اللي كارت اللي صار فيه damage هو + +75 +00:06:10,010 --> 00:06:13,090 +permanent damage لأن مفيش فيه vascularization، أي + +76 +00:06:13,090 --> 00:06:16,050 +جزء أو عضو في جسم الإنسان فيه بيكون highly + +77 +00:06:16,050 --> 00:06:19,830 +vascularized أو بيكون فيه عنده نوع من حاجة بيسميها + +78 +00:06:19,830 --> 00:06:29,590 +self repair، طبعاً كمان الـ... الـ bone كمان في عندها + +79 +00:06:29,590 --> 00:06:35,210 +خاصية أو property للـ configuration يعني in + +80 +00:06:35,210 --> 00:06:37,590 +response to mechanical demand، إيش معناه هذا + +81 +00:06:37,590 --> 00:06:41,310 +الكلام؟ إنه أساساً العظمة بتقدر تعمل حاجة اسمها + +82 +00:06:41,310 --> 00:06:44,270 +remodeling وبتقدر حاجة تعمل configuration يعني + +83 +00:06:44,270 --> 00:06:48,610 +احنا إيش بيصير فيه ضغط على العظام؟ كيف بيصير الـ + +84 +00:06:48,610 --> 00:06:51,910 +formation تبع العظام؟ يعني احنا كنت بذكر ولما + +85 +00:06:51,910 --> 00:06:55,710 +بدينا في مصادر الـ biomechanic كنا بنقول، الرواد الفضاء + +86 +00:06:55,710 --> 00:06:59,130 +اللي بيسافروا على الفضاء، هدول لإن بيكون فيش عندهم + +87 +00:06:59,130 --> 00:07:03,590 +blood نتيجة إن مافيش رد فعل جاذبية في الفضاء، فهدول + +88 +00:07:03,590 --> 00:07:07,910 +بتضعف عظامهم، ليش بتضعف عظامهم؟ لإن بيصيرش ممارسة + +89 +00:07:07,910 --> 00:07:13,410 +للـ stress on that point، كمان لو يعني نضرب مثل كاني + +90 +00:07:13,410 --> 00:07:17,790 +أنه لو مثلاً أنا بذكر في أحد المرات اللي كنت بعيش + +91 +00:07:17,790 --> 00:07:23,850 +فيها طفل في خلّينا نقول في أوائل التسعينات كان طفل + +92 +00:07:23,850 --> 00:07:27,370 +هدفنا عنده absence of tibia فكان الـ action من الـ + +93 +00:07:27,370 --> 00:07:30,090 +surgeon إنه... وكان في عنده fibula، الـ action من الـ + +94 +00:07:30,090 --> 00:07:34,130 +surgeon إيش عمل؟ راح قلب حط الفيبيولا هذه مركز الـ + +95 +00:07:34,130 --> 00:07:38,570 +tibia وخلّاه إن تربى الطفل عن المشي using اللي هو الـ + +96 +00:07:38,570 --> 00:07:42,630 +auxiliary crunches، ومع الوقت الفيبيولا هذه كبرت + +97 +00:07:42,630 --> 00:07:46,630 +وصارت عملت... وعملوا Arthrodesis طبعاً لإن هذه + +98 +00:07:46,630 --> 00:07:54,880 +الفيبيولا كبرت وصارت عريضة، وبتستحمل، وزمّت وكبرت وحلت + +99 +00:07:54,880 --> 00:08:00,380 +محل التيبيا على أمد إن الدكتور كان بيده يعمل تشكيل + +100 +00:08:00,380 --> 00:08:06,380 +لمفصل ركبة بعد فترة عامين السنة، فعشان هيك عملية الـ + +101 +00:08:06,380 --> 00:08:09,360 +configuration هذه إنه بيصير إذا صار mechanical + +102 +00:08:09,360 --> 00:08:14,090 +demand أو صار فيه stress على الـ bone في أي تجاه أو + +103 +00:08:14,090 --> 00:08:18,010 +نلاحظ كمان الأطفال الـ CP مثلاً اللي بيمشوا على الـ + +104 +00:08:18,010 --> 00:08:22,070 +knee وبيمشوا بالنيل يعني فبتلاقي الـ knee تبعتهم + +105 +00:08:22,070 --> 00:08:25,850 +enlarged وكمان الـ ankle enlarged، ليش؟ لإن بيكون + +106 +00:08:25,850 --> 00:08:30,010 +فيه mechanical demand على الـ bone فتصير فيها + +107 +00:08:30,010 --> 00:08:35,990 +growth مختلف عن إنهم كمان الـ bone بتعمل reshape أو + +108 +00:08:35,990 --> 00:08:40,730 +عملية remodeling، معناه إنه لو بنكسر، مكسر مثلاً الـ + +109 +00:08:40,730 --> 00:08:43,370 +bone بيصير في عملية الـ healing، الـ healing والـ + +110 +00:08:43,370 --> 00:08:47,090 +calcification بتكونش خلّينا نقول مسكولة بشكل جيد أو + +111 +00:08:47,090 --> 00:08:51,950 +ممكن تكون فيها شوية اعوجاج، فبعد فترة بنلاقي بيصير + +112 +00:08:51,950 --> 00:08:59,390 +في عملية reabsorption للـ bone وبتعمل formation + +113 +00:08:59,390 --> 00:09:03,570 +لـ bone جديدة وبيصير في عينيه ديودة، يعني عملية ثقل + +114 +00:09:03,570 --> 00:09:07,270 +للبون، دي قاعدة الشيء تبعها + +115 +00:09:09,570 --> 00:09:13,710 +هذا الشكل بيوضح عمل الـ Osteoblast وOsteoclast + +116 +00:09:13,710 --> 00:09:19,990 +الموجودين، اللي هو المكونات العظم نفسها أو الخلايا + +117 +00:09:19,990 --> 00:09:23,090 +المكونات العظم اللي احنا بنتعرف عليها في الـ slide + +118 +00:09:23,090 --> 00:09:26,510 +اللي بعدها، في عندنا Osteoblast، في عندنا Osteocytes + +119 +00:09:26,510 --> 00:09:31,320 +اللي هي الـ mature bone cell، وفي عندنا الـ osteoclast + +120 +00:09:31,320 --> 00:09:38,180 +اللي بتعمل عملية الـ resorption للبون + +121 +00:09:38,180 --> 00:09:41,480 +اللي بتعمل عملية الـ remodeling، فبتصير فيه ابتداء + +122 +00:09:41,480 --> 00:09:44,500 +خلايا جديدة عن طريق الـ osteoclast اللي بنسميه + +123 +00:09:44,500 --> 00:09:50,580 +immature bone cell، وبعدها بيصير في عندنا كمان الـ + +124 +00:09:50,580 --> 00:09:53,780 +osteoclast اللي بتعمل عملية الـ dissolving اللي + +125 +00:09:53,780 --> 00:09:58,870 +بتفتت العظمة وبتعملها، فنقول تأكلها، تصير عملية + +126 +00:09:58,870 --> 00:10:02,430 +remodeling طبعا أن العظمة بالآخر تظهر بشكل جيد + +127 +00:10:02,430 --> 00:10:10,050 +وممتاز و بشكل اللي هو المفروض طبعا the bone density + +128 +00:10:10,050 --> 00:10:15,150 +بتختلف دائما نتيجة ال disuse زي ما حكينا ال + +129 +00:10:15,150 --> 00:10:18,010 +changes in bone density are commonly observed + +130 +00:10:18,010 --> 00:10:21,750 +after a period of either disuse or a great + +131 +00:10:21,750 --> 00:10:26,690 +increase of hunger يعني إحنا لو أرهقنا العضلة كثيرا + +132 +00:10:27,210 --> 00:10:33,570 +هتصير في عينها مشكلة لإنها مش هتصير قليلة أو إذا + +133 +00:10:33,570 --> 00:10:37,870 +احنا كمان عملنا لها إهمال للعقل هذا زي ما حكينا عن + +134 +00:10:37,870 --> 00:10:39,590 +الـosteoporosis اللي في الفضاء اللي ما بتفضوش + +135 +00:10:39,590 --> 00:10:43,790 +stress على the bone سبعة فهي الطبعة كمان ال change + +136 +00:10:43,790 --> 00:10:46,750 +seen في the bone shape during fractured healing وهذا + +137 +00:10:46,750 --> 00:10:51,660 +اتكلمنا عنه أحيانا أو بعد العمليات الجراحية الـ + +138 +00:10:51,660 --> 00:10:54,720 +Bone adapts to mechanical demand that presses upon + +139 +00:10:54,720 --> 00:10:58,460 +it وزي ما قلنا كل ما زاد ال stress على the bone كل + +140 +00:10:58,460 --> 00:11:03,360 +ما صار فيه عملية بناء أكثر إنه كان فيه اتجاه خليني + +141 +00:11:03,360 --> 00:11:08,700 +أقول سلبي يعني زيادة أو زيادة غير طبيعية أو نتيجة + +142 +00:11:08,700 --> 00:11:12,660 +poor position أو الاعتماد على poor position فبصير + +143 +00:11:12,660 --> 00:11:19,020 +عملية بناء العظم خلاص إيش مكونات ال bone؟ بمثل هذه + +144 +00:11:19,020 --> 00:11:23,760 +بنشوف إن مكونات ال bone إنها the Bone Matrix الـ + +145 +00:11:23,760 --> 00:11:27,840 +Bone Matrix عبارة عن Calcified .. the Bone Matrix + +146 +00:11:27,840 --> 00:11:33,760 +of Calcified Tissue حكينا عن the Bone Cell يعني + +147 +00:11:33,760 --> 00:11:37,640 +the Osteoplast هي خلايا البناء في العظم يعني الـ + +148 +00:11:37,640 --> 00:11:42,520 +Osteocyte هي عبارة عن .. هي the Mature Bone Cell و + +149 +00:11:42,520 --> 00:11:45,640 +the Osteoplast هي بتعمل عملية الـ Absorption + +150 +00:11:45,640 --> 00:11:49,920 +لخلايا سيئة عشان تعمل عملية إعادة البناء عن طريق + +151 +00:11:49,920 --> 00:11:53,570 +the Osteoplast أما the periosteum هو the outer covering + +152 +00:11:53,570 --> 00:11:58,050 +of the bone و the endosteum احنا درسنا في المصطلحات + +153 +00:11:58,050 --> 00:12:03,430 +في عندنا ال prefix اللي بتدللي على الكلمة + +154 +00:12:03,430 --> 00:12:07,490 +بالإنكليزي طبعا بري معناها around around means the + +155 +00:12:07,490 --> 00:12:11,390 +outer cover of the bone endosteum الاندو كلمة اندو + +156 +00:12:11,390 --> 00:12:16,650 +means inside أو in هي the inner lining of the bone + +157 +00:12:16,650 --> 00:12:21,760 +وهذا الشكل التوضيحي يورينا هذه the long bone الـ + +158 +00:12:21,760 --> 00:12:26,980 +long bone هذه عبارة عن the diaphysis و الـ + +159 +00:12:26,980 --> 00:12:32,120 +epiphysis فلو طلعنا عن the epiphysis هنا فبنشوف أنه + +160 +00:12:32,120 --> 00:12:35,500 +في عندنا the yellow bone marrow اللي بيكون في + +161 +00:12:35,500 --> 00:12:38,740 +adipose tissue و في عندنا the compact bone هي the + +162 +00:12:38,740 --> 00:12:41,860 +hard surface of the bone في عندنا the periosteum ال + +163 +00:12:41,860 --> 00:12:45,840 +outer surface هذا في عندنا شربي fibers هذه بتعمل + +164 +00:12:45,840 --> 00:12:50,510 +على انتصاقthe periosteum مع the compact bone وهنا زي + +165 +00:12:50,510 --> 00:12:54,890 +ما أنتم شايفين the nutrient arteries بتعمل + +166 +00:12:54,890 --> 00:12:58,550 +attachment مع the periosteum عشان تعطيني الغذاء + +167 +00:12:58,550 --> 00:13:06,490 +اللازم لهذه العظام طبعا هنا بننتقل لنقطة كثيرا + +168 +00:13:06,490 --> 00:13:11,030 +مهمة في the bio mechanics هي the behavior of the + +169 +00:13:11,030 --> 00:13:16,930 +bone tissue under various loading modes the Load + +170 +00:13:16,930 --> 00:13:23,670 +اللي ممكن the bone تتحمله هنا the bone ممكن يصير + +171 +00:13:23,670 --> 00:13:26,590 +فيها alteration للproperties و the configuration + +172 +00:13:26,590 --> 00:13:29,850 +the response to mechanical changes زي ما اتكلمنا + +173 +00:13:29,850 --> 00:13:35,230 +عن the fibula اللي صارت تبع بحكم the stresses اللي + +174 +00:13:35,230 --> 00:13:40,750 +كانت ملقا عليها وتحويل خلينا نقول مكانها طبعا + +175 +00:13:40,750 --> 00:13:46,340 +بتصير في عندنا the forces هذه اللي ممكن تأثر على + +176 +00:13:46,340 --> 00:13:51,920 +التغيير في the size و the shape في the bone، طيب، + +177 +00:13:51,920 --> 00:13:55,960 +إيش the loads اللي ممكن تستخدمها تتعرض لها العضلات؟ + +178 +00:13:55,960 --> 00:13:58,580 +طبعاً في عندنا various of loading منها the + +179 +00:13:58,580 --> 00:14:01,100 +compression، the tension، the bending، the shear، the + +180 +00:14:01,100 --> 00:14:04,880 +torsion و the combined اللي هو ممكن ياخد أكثر من + +181 +00:14:04,880 --> 00:14:11,060 +واحدة من هدول the loads the compression الـ + +182 +00:14:11,060 --> 00:14:14,740 +compression أي إشي إحنا بنضغطه فبروح باتجاه أنه + +183 +00:14:14,740 --> 00:14:19,000 +بيعرض و بيأثر أما the bending فهي non-actual force + +184 +00:14:19,000 --> 00:14:21,260 +طبعا the compression ممكن تتشغل مع actual forces + +185 +00:14:21,260 --> 00:14:27,940 +أما the bending فهي non-actual force بمعنى أنه + +186 +00:14:27,940 --> 00:14:30,540 +ممكن أنه يصير الثاني من الوسط يعني في عندنا two + +187 +00:14:30,540 --> 00:14:35,720 +forces على الـ sites وفي عندنا force معاكس + +188 +00:14:35,720 --> 00:14:39,440 +يلاقيهم في الوسط فتعمل عملية bending the shear + +189 +00:14:39,440 --> 00:14:44,440 +عملية الفصد عملية الفصد تعمل عملية إزاحة فصد ل two + +190 +00:14:44,440 --> 00:14:47,700 +surfaces of the bone أما the torsion فهي عملية + +191 +00:14:47,700 --> 00:14:52,320 +الالتواء و the combined بتاخد مجموعة بتجمع من the + +192 +00:14:52,320 --> 00:14:55,320 +bending و the shear forces + +193 +00:14:57,730 --> 00:15:01,830 +the tension و the compression احنا دفعنا ان هي normal axial + +194 +00:15:01,830 --> 00:15:06,090 +forces لأنها perpendicular to the cross section of + +195 +00:15:06,090 --> 00:15:09,390 +the structure under load directed either away from + +196 +00:15:09,390 --> 00:15:12,570 +the center of the segment or towards طبعا لو بتكون + +197 +00:15:12,570 --> 00:15:16,170 +directed away from the center فهي بتكون tension + +198 +00:15:16,170 --> 00:15:20,730 +أما towards من the center فهي compression the tensile + +199 +00:15:20,730 --> 00:15:25,490 +load هي stress and strain + +200 +00:15:35,810 --> 00:15:39,010 +التغيير اللي بيصير في the shape هو عبارة عن + +201 +00:15:39,010 --> 00:15:43,850 +lengthening and narrowing يعني إذا بنلاحظ إذا احنا + +202 +00:15:43,850 --> 00:15:49,430 +مسكنا مطاطة وشدناها إيش اللي بيصير اللي بيصير انها + +203 +00:15:49,430 --> 00:15:51,870 +احنا بنقول the طينة الحرة اللي بيلعب بطيها الأطفال + +204 +00:15:51,870 --> 00:15:54,490 +لما احنا بنشدها إيش اللي بيصير فيها + +205 +00:15:58,110 --> 00:16:00,770 +أما إذا سحبناها في the compression فهي تتأثر على شكل + +206 +00:16:00,770 --> 00:16:05,230 +the كرة فهي تتأثر على + +207 +00:16:05,230 --> 00:16:09,970 +شكل the كرة + +208 +00:16:09,970 --> 00:16:13,370 +فهي + +209 +00:16:13,370 --> 00:16:16,950 +تتأثر على + +210 +00:16:16,950 --> 00:16:23,010 +شكل + +211 +00:16:23,010 --> 00:16:25,860 +the كرة في موضوع the original في هذا the original + +212 +00:16:25,860 --> 00:16:29,080 +shape هنا لما بيصير فيه ان the compression الجزيئات + +213 +00:16:29,080 --> 00:16:32,520 +بتتدخل مع بعضها تضغط على بعضها فبيأسفر وبيعرض في + +214 +00:16:32,520 --> 00:16:35,780 +the shape وهنا الجزيئات بتتبعد عن بعضها في the + +215 +00:16:35,780 --> 00:16:43,340 +tension و بتطول وبيطول هاي تبع the صورة التوضيحية + +216 +00:16:43,340 --> 00:16:47,030 +أخرى the compression and tension the compression + +217 +00:16:47,030 --> 00:16:50,470 +loading بتأثر على التعصين على the strain in the + +218 +00:16:50,470 --> 00:16:53,230 +form of shortening and widening طبعا the maximum + +219 +00:16:53,230 --> 00:16:56,130 +compressive stress دائما بيكون من قبلين + +220 +00:16:56,130 --> 00:17:00,890 +perpendicular بيكون عمودي على the applied load + +221 +00:17:00,890 --> 00:17:07,030 +وكمان the tensile stress are + +222 +00:17:07,030 --> 00:17:10,270 +applied to the segment resistant للإضاءة + +223 +00:17:12,850 --> 00:17:15,910 +عندما نريد أن نقطع شيئا أو نريد أن نقطع شيئا أو نريد + +224 +00:17:15,910 --> 00:17:16,690 +أن نقطع شيئا أو نريد أن نقطع شيئا أو نريد أن نقطع شيئا + +225 +00:17:16,690 --> 00:17:19,190 +أو نريد أن نقطع شيئا أو نريد أن نقطع شيئا أو نريد أن + +226 +00:17:19,190 --> 00:17:21,970 +نقطع شيئا أو نريد أن نقطع شيئا أو نريد أن نقطع شيئا أو + +227 +00:17:21,970 --> 00:17:23,350 +نريد أن نقطع شيئا أو نريد أن نقطع شيئا أو نريد أن نقطع + +228 +00:17:23,350 --> 00:17:25,090 +شيئا أو نريد أن نقطع شيئا أو نريد أن نقطع شيئا أو نريد + +229 +00:17:25,090 --> 00:17:25,570 +أن نقطع شيئا أو نريد أن نقطع شيئا أو نريد أن نقطع شيئا + +230 +00:17:25,570 --> 00:17:28,110 +أو نريد أن نقطع شيئا أو نريد أن نقطع شيئا أو نريد أن + +231 +00:17:28,110 --> 00:17:35,190 +نقطع شيئا أو نريد أن نقطع شيئا أو + +232 +00:17:35,190 --> 00:17:39,360 +يبقى when tensile stress are applied to a + +233 +00:17:39,360 --> 00:17:41,620 +segment، the resistant unit من the كون of this + +234 +00:17:41,620 --> 00:17:47,340 +segment أو قطر من the كون تتخلص، لكن في the + +235 +00:17:47,340 --> 00:17:52,760 +compressive forces، لا، تزيد، التي تبعها، يبقى + +236 +00:17:52,760 --> 00:17:56,640 +the resistant unit of one is the breaking point of + +237 +00:17:56,640 --> 00:18:02,380 +one، متى احنا في العظمة بتقدر تتحمل load معين، لو + +238 +00:18:02,380 --> 00:18:05,900 +زاد the load هاد عليها فطبعا ممكن تصير فيها + +239 +00:18:05,900 --> 00:18:11,200 +breaking للـ bone طبعا بعض الباحثين قالوا ان عشرة + +240 +00:18:11,200 --> 00:18:15,260 +kilogram per millimeter مربع for the resistance of + +241 +00:18:15,260 --> 00:18:19,220 +bone against tension هذا the value of the breaking + +242 +00:18:19,220 --> 00:18:23,500 +bone of other type of bones تختلف من the + +243 +00:18:23,500 --> 00:18:27,020 +compression لل bending لل shear force طبعا احنا + +244 +00:18:27,020 --> 00:18:30,320 +قلنا كل ما كانت العضلة مشدودة العضلة مشدودة كل ما + +245 +00:18:30,320 --> 00:18:37,400 +كان the harm أسرع و the Load اللي بتتحمله أقل، بس + +246 +00:18:37,400 --> 00:18:41,100 +احنا بتخيل عم نتكلم عن عشرة كيلو جرام بالملي متر + +247 +00:18:41,100 --> 00:18:44,440 +مربع، معناه لما يصير في عندنا breaking of the + +248 +00:18:44,440 --> 00:18:48,260 +bone، معناه القوة المؤثر عليها اللي بيصير للناس + +249 +00:18:48,260 --> 00:18:51,360 +اللي عندهم عندهم قصور، معناه قوة رهيبة أكبر من + +250 +00:18:51,360 --> 00:18:57,860 +العشرة كيلو جرام بالملي متر مربع في the fresh bone + +251 +00:18:57,860 --> 00:19:05,240 +اتضح أنه التأثير على the tension resistance لو كانت + +252 +00:19:05,240 --> 00:19:11,720 +اتعرضة للـ bone لـ tension فتحتاج لـ 12.41 كيلو + +253 +00:19:11,720 --> 00:19:15,920 +جرام للملي متر المربع لكن لو كان compression + +254 +00:19:15,920 --> 00:19:19,560 +resistance لو كانت متعرضة لضغط معين مثلا + +255 +00:19:24,500 --> 00:19:30,100 +هي تحتاج ل 16.8 + +256 +00:19:30,100 --> 00:19:34,560 +كيلو جرام لكل متر مربع هنا بنفهم من هذه الجملة أن + +257 +00:19:34,560 --> 00:19:40,600 +ال tension forces are destructive more than + +258 +00:19:40,600 --> 00:19:42,320 +compression force + +259 +00:19:45,060 --> 00:19:49,060 +or compression is substantially greater than that + +260 +00:19:49,060 --> 00:19:57,200 +for tension. the ratio بتاخد من 1 ل 0.73 هذا يعني أن + +261 +00:19:57,200 --> 00:20:00,880 +ال tension load have more destructive effects on + +262 +00:20:00,880 --> 00:20:06,720 +bone than compressive load. طبعا هذا يعني بالكلمات + +263 +00:20:06,720 --> 00:20:13,030 +بسيطة لو اتعرضت العظام لل tension فبتنكسر + +264 +00:20:13,030 --> 00:20:19,090 +أسرع من أن تتعرض ل compression force or load. روح + +265 +00:20:19,090 --> 00:20:23,690 +لل bending و ال shear و ال torsion load. هدولة non + +266 +00:20:23,690 --> 00:20:27,890 +axial + +267 +00:20:27,890 --> 00:20:31,990 +forces occur when a load is applied to a structure + +268 +00:20:32,350 --> 00:20:36,790 +الأمر ده because it to bend about an axis. means + +269 +00:20:36,790 --> 00:20:41,030 +هنا هي non axial force. المعنى أنه لو اتعرضت للتاني + +270 +00:20:41,030 --> 00:20:46,150 +هنا فبصير في عندنا من ناحية compression ومن ناحية + +271 +00:20:46,150 --> 00:20:49,510 +التانية tension. يعني الناحية اللي بنروح في اتجاهها + +272 +00:20:49,510 --> 00:20:53,510 +في التاني فهي الجزيئات تبعتها بتتدخل والناحية + +273 +00:20:53,510 --> 00:20:57,510 +التانية اللي بنعرضها ل .. اللي بتكون البرانية + +274 +00:20:57,510 --> 00:21:02,000 +بتتعرض ل tension زي ما احنا شايفين بالصورة بصورة + +275 +00:21:02,000 --> 00:21:06,940 +هنا في عندنا compression و من الخارج بيكون في + +276 +00:21:06,940 --> 00:21:10,320 +عندنا tension و هذه ال force. هنا في عندنا هاي two + +277 +00:21:10,320 --> 00:21:19,780 +forces على ال sides و هنا في one force في المنتصف + +278 +00:21:19,780 --> 00:21:25,900 +ضغط تمام. هدولة جزيئات بتدخل و هدولة جزيئات بتبقى + +279 +00:21:25,900 --> 00:21:30,630 +طبعا ال tension هنا القريب من ال center القليل يعني + +280 +00:21:30,630 --> 00:21:34,470 +كل ما بعيدنا عن الـcenter كل ما كان ال tension + +281 +00:21:34,470 --> 00:21:38,590 +أكبر. يبقى this means that the farther the stress + +282 +00:21:38,590 --> 00:21:42,010 +is from the axis the higher is their magnitude + +283 +00:21:42,010 --> 00:21:46,470 +وطبعا بيكون destructive أكتر و .. و .. حد رايح + +284 +00:21:46,470 --> 00:21:50,390 +نشوف كيف تطبع فيه النقل الفارث اللي فادر فبتكون هو + +285 +00:21:50,390 --> 00:21:54,550 +الفارث اللي هنا acting هنا اللي بتتأثر فبتكون + +286 +00:21:54,550 --> 00:21:57,900 +عبارة عن قيمة الفارث هذه بالـ perpendicular + +287 +00:21:57,900 --> 00:22:03,000 +distance بين الـ axis و هنا. يعني لو افترضنا هذه ال + +288 +00:22:03,000 --> 00:22:08,340 +force خمسة مثلا خمسة نيوتن وهذه المسافة اتنين + +289 +00:22:08,340 --> 00:22:17,100 +اتنين اتنين متر مثلا فبتكون خمسة ضارب اتنين يعني + +290 +00:22:17,100 --> 00:22:24,830 +عشرة نيوتن. هذا نسميه عزم الزواج ترسنا بالفصل أما + +291 +00:22:24,830 --> 00:22:28,290 +الـ four point bending بتعملي two forces couple + +292 +00:22:28,290 --> 00:22:31,750 +acting on the structure بتعطينا two equal moments + +293 +00:22:31,750 --> 00:22:36,490 +في عندنا force couple. في عندنا ال two equal forces + +294 +00:22:36,490 --> 00:22:40,210 +تنتين parallel equal in magnitude and opposite in + +295 +00:22:40,210 --> 00:22:46,670 +direction. نروح لهجة اسمها share loading. a force is + +296 +00:22:46,670 --> 00:22:49,590 +applied parallel to the surface of the structure + +297 +00:22:49,590 --> 00:22:54,060 +يعني هذه بنمثلها احنا كده. في عندنا كرتونة الكارتونة + +298 +00:22:54,060 --> 00:22:59,760 +هذه مثلا مليئة بأي شيء سنقول الـ Sphinx بالضغوط + +299 +00:22:59,760 --> 00:23:06,220 +فلما تجي نضغط عليها تصبح عملية إزاحة للـ Sphinx + +300 +00:23:06,220 --> 00:23:10,020 +فتصبح الكارتونة ميلة. فهذه اللي تصبح في جذيئات + +301 +00:23:10,020 --> 00:23:14,320 +الكارتونة Sharing Force. طبعا هذه بتعمل زاوية تصبح + +302 +00:23:14,320 --> 00:23:19,060 +الكارتونة عاملة زاوية زي ما هو موضح بالرسم هنا + +303 +00:23:19,060 --> 00:23:23,500 +يعني هنا نتكلم عن Angulation. يبقى الـshear force + +304 +00:23:23,500 --> 00:23:28,860 +applied بتقل النتيجة عليها في جوات الموليكول أه في + +305 +00:23:28,860 --> 00:23:34,180 +عندنا angular shape يعني deformation في اتجاه ال + +306 +00:23:34,180 --> 00:23:41,440 +angular shape أو ال angular منطقة في الـtorsion + +307 +00:23:41,440 --> 00:23:46,180 +loading. طبعا الـstructure is subjected to أكتر من + +308 +00:23:46,180 --> 00:23:48,780 +force منها الـshear منها ال tension and + +309 +00:23:48,780 --> 00:23:52,170 +compression. هي عملية الـ LTY يعني زي ما نعمل عصر + +310 +00:23:52,170 --> 00:23:56,910 +الغسيل كيف بنعمل عصر الغسيل بنسك الهدف وبنطويه كده + +311 +00:23:56,910 --> 00:24:02,990 +وبعدين بنعمله عملية torsion. يبقى في عندنا تلاتة من + +312 +00:24:02,990 --> 00:24:07,870 +ال laws أو combination of share tension and + +313 +00:24:07,870 --> 00:24:12,560 +condition. الـ Share stress are distributed over the + +314 +00:24:12,560 --> 00:24:16,740 +entire structure لأننا بنعمل عملية باستمرار نحن + +315 +00:24:16,740 --> 00:24:19,660 +بنحصل بنعمل عملية إلتي وقت these stress are + +316 +00:24:19,660 --> 00:24:23,060 +proportional to the distance from the natural + +317 +00:24:23,060 --> 00:24:26,860 +neutral axis. كل ما بعيدنا عن ال axis ال share + +318 +00:24:26,860 --> 00:24:32,620 +process بتكون .. نروح لحاجة اسمها stress and + +319 +00:24:32,620 --> 00:24:38,300 +strain. ال stress is defined as the load per unit + +320 +00:24:38,860 --> 00:24:43,460 +التي تتطور على محطة طبيعية في مصطلحات تتعامل بطاقة + +321 +00:24:43,460 --> 00:24:44,100 +تتعامل بطاقة تتعامل بطاقة تتعامل بطاقة تتعامل + +322 +00:24:44,100 --> 00:24:45,860 +بطاقة تتعامل بطاقة تتعامل بطاقة تتعامل بطاقة + +323 +00:24:45,860 --> 00:24:50,720 +تتعامل بطاقة تتعامل بطاقة تتعامل بطاقة تتعامل + +324 +00:24:50,720 --> 00:24:52,100 +بطاقة تتعامل بطاقة تتعامل بطاقة تتعامل بطاقة + +325 +00:24:52,100 --> 00:24:54,820 +تتعامل بطاقة تتعامل بطاقة تتعامل بطاقة تتعامل + +326 +00:24:54,820 --> 00:25:01,980 +بطاقة تتعامل بطاقة تتعامل بطاقة + +327 +00:25:01,980 --> 00:25:07,880 +تتعامل بطاقة + +328 +00:25:07,880 --> 00:25:13,920 +تتعاملحجر هو عبارة عن external partial pressure + +329 +00:25:13,920 --> 00:25:18,360 +مابقاش صار في العضمة، العضمة تهشها، ليش؟ لأنه صار + +330 +00:25:18,360 --> 00:25:25,680 +في أن stress جواة العضمة ضغط عليها نتج عنها هذا ال + +331 +00:25:25,680 --> 00:25:31,320 +injury اللي حصلت. لبقى هي عبارة عن load بال unit + +332 +00:25:31,320 --> 00:25:35,080 +that develops on a planned surface within the + +333 +00:25:35,080 --> 00:25:39,390 +structure. ال Stress بيكون نتيجة الـ External Parts + +334 +00:25:39,390 --> 00:25:43,830 +لكن هو عبارة عن Internal تغيير في الـ Internal + +335 +00:25:43,830 --> 00:25:48,530 +Structure أو Stress في الـ Internal Structure. طب + +336 +00:25:48,530 --> 00:25:52,810 +كمان Defined as Inter molecular resistance within + +337 +00:25:52,810 --> 00:25:58,170 +a body to deforming action of an outside force. طب + +338 +00:25:58,170 --> 00:26:01,910 +أنا بقدر من أرجع لمرطبان الزعتر. هذا يعني بلاي أقرب + +339 +00:26:01,910 --> 00:26:07,510 +مثلًا الزعتر في حالته العادى بيكون مليان. لو احنا + +340 +00:26:07,510 --> 00:26:11,270 +حبينا نمليه اكتر و اكتر فايش بنروح نروح نضغط عليه + +341 +00:26:11,270 --> 00:26:17,310 +ايش بنعمل نضغط عليه external force. ايش بيصير بيصير + +342 +00:26:17,310 --> 00:26:19,570 +ال intermolecular resistance هنا + +343 +00:26:22,700 --> 00:26:26,620 +بتصير انت تضغط احنا نضغط وهي بتقل المساحة في ضغط + +344 +00:26:26,620 --> 00:26:30,920 +من فوق وهي بتقل المساحة فبتدخل ال جزيئات لحد ما + +345 +00:26:30,920 --> 00:26:33,960 +نوصل لمرحلة معينة ان نعبي كل المرتبانات و نضغط و + +346 +00:26:33,960 --> 00:26:36,780 +نضغط و نضغط و نضغط و نضغط و نضغط و نضغط و نضغط و + +347 +00:26:36,780 --> 00:26:40,100 +نضغط و نضغط و نضغط و نضغط و نضغط و نضغط و نضغط و + +348 +00:26:40,100 --> 00:26:46,280 +نضغط و نضغط و نضغط و نضغط و نضغط و نضغط و نضغط و ن + +349 +00:26:46,350 --> 00:26:52,350 +هنا نوتن بصنتمتر سكوار ونوتن بميتر سكوار وبسكال + +350 +00:26:52,350 --> 00:26:56,150 +بميتر + +351 +00:26:56,150 --> 00:26:59,190 +سكوار بميتر سكوار بميتر سكوار بميتر سكوار بميتر + +352 +00:26:59,190 --> 00:26:59,870 +سكوار بميتر سكوار بميتر سكوار بميتر سكوار بميتر + +353 +00:26:59,870 --> 00:27:03,590 +سكوار بميتر سكوار بميتر سكوار بميتر سكوار بميتر + +354 +00:27:03,590 --> 00:27:09,710 +سكوار بميتر سكوار بميتر سكوار + +355 +00:27:09,710 --> 00:27:16,740 +بميتر سكواريعني الـ Normal Stress لما تكون في عنا + +356 +00:27:16,740 --> 00:27:20,460 +tension أو compression فالـ Simple تبعها هي عبارة + +357 +00:27:20,460 --> 00:27:25,400 +عن load perpendicular to the planned surface اللي + +358 +00:27:25,400 --> 00:27:28,600 +هي tension or compression و الـ Simple تبعها sigma + +359 +00:27:28,600 --> 00:27:32,160 +أما الـ shear لو كنا بنتعرض ل parallel to the + +360 +00:27:32,160 --> 00:27:36,380 +planned surface الـ Simple تبعها الـ Tau يبقى ال + +361 +00:27:36,380 --> 00:27:39,760 +equation of stress عبارة عن stress. احنا عارفين أن + +362 +00:27:39,760 --> 00:27:42,660 +ال stress زي ال pressure. الـ pressure هو external + +363 +00:27:42,660 --> 00:27:46,060 +force بينما ال stress هو internal force. ال stress + +364 +00:27:46,060 --> 00:27:52,820 +هي عبارة عن force على الاليان. طبعا وهذا شكل توضيح + +365 +00:27:52,820 --> 00:27:59,280 +كيف بتصير عمليات ال stress + +366 +00:27:59,280 --> 00:28:03,760 +و ال internal forces اللي بتصير سواء كانت في + +367 +00:28:03,760 --> 00:28:09,660 +normal stress ولا share stress. لأن ال share بتصير + +368 +00:28:09,660 --> 00:28:10,840 +عملية بزاوية + +369 +00:28:13,270 --> 00:28:19,890 +الجزء من التقاط هو باسكال الذي ينتج من قوة واحد + +370 +00:28:19,890 --> 00:28:24,210 +نيوتن على واحد نيوتن. مرتبط بمجموعه عبارة عن مجموعه + +371 +00:28:24,210 --> 00:28:26,270 +عبارة عن مجموعه عبارة عن مقاطع أساطير ومقاطع + +372 +00:28:26,270 --> 00:28:27,530 +أساطير ومقاطع أساطير ومقاطع أساطير ومقاطع أساطير + +373 +00:28:27,530 --> 00:28:28,850 +ومقاطع أساطير ومقاطع أساطير ومقاطع أساطير ومقاطعة + +374 +00:28:28,850 --> 00:28:30,930 +أساطير ومقاطعة أساطير ومقاطعة أساطير ومقاطعة + +375 +00:28:30,930 --> 00:28:34,930 +أساطير ومقاطعة + +376 +00:28:34,930 --> 00:28:39,310 +أساطير ومقاطعة + +377 +00:28:39,310 --> 00:28:42,470 +أساطير ومقاطعة أساطير ومقاطعة أساطير ومقاطعة + +378 +00:28:42,470 --> 00:28:47,240 +أساطير ومقاطعة التغيير اللي حصل بالشكل زي ما حكينا احنا + +379 +00:28:47,240 --> 00:28:52,840 +لو ضغطنا مرتبع الزعتر بتقل كمية الزعتر فهذا تغيير + +380 +00:28:52,840 --> 00:28:58,420 +صار deformation في الشكل، الـ strain هو عبارة عن + +381 +00:28:58,420 --> 00:29:01,720 +deformation that occurs at a point in a structure + +382 +00:29:01,720 --> 00:29:02,980 +under loading + +383 +00:29:08,420 --> 00:29:12,100 +بـlinear deformation أو linked link دائما كلمة + +384 +00:29:12,100 --> 00:29:16,240 +normal فهي linear أو perpendicular in case of + +385 +00:29:16,240 --> 00:29:19,480 +tension or shortening in case of compression + +386 +00:29:19,480 --> 00:29:24,140 +divided by the structure's original length يبقى ال + +387 +00:29:24,140 --> 00:29:27,760 +change in length بتصير عبارة عن normal strain تصير + +388 +00:29:27,760 --> 00:29:31,340 +الـ change of length على الـ original يعني بتشوف + +389 +00:29:31,340 --> 00:29:36,090 +قداش قصر على الـ length فتطلع لنا الـ strain يعني هلأ إذا + +390 +00:29:36,090 --> 00:29:44,150 +لو طلعنا افترضنا أنه كان مثلا الـ length الطبيعي + +391 +00:29:44,150 --> 00:29:49,770 +التغيير في الـ length صار مثلا قصر أربعة سم مثلا + +392 +00:29:49,770 --> 00:29:54,210 +كان في عندنا عشرة صار أربعة بنقول أربعة على الـ original + +393 +00:29:54,210 --> 00:29:57,970 +length كان عشرة أربعة على عشرة و ثم بتطلع لنا الـ + +394 +00:29:57,970 --> 00:29:58,310 +epsilon + +395 +00:30:02,130 --> 00:30:06,430 +نروح لـ Most Important Mechanical Properties of + +396 +00:30:06,430 --> 00:30:13,210 +Bone Against Loading لدينا Strength و Stiffness + +397 +00:30:13,210 --> 00:30:17,390 +طبعا هنا كيف نقدر نحدد قوة العظم؟ في حاجة اسمها + +398 +00:30:17,390 --> 00:30:20,890 +Modulus of Elasticity قلنا إن + +399 +00:30:20,890 --> 00:30:25,730 +إحنا لما تزيد الـ Elasticity بيساعد على إن العظم + +400 +00:30:25,730 --> 00:30:31,080 +يقل انكساره للإجهاد يبقى الـ Value of stiffness + +401 +00:30:31,080 --> 00:30:36,620 +obtained by dividing of stress على الـ strain كم + +402 +00:30:36,620 --> 00:30:40,940 +أتعرضت لضغط وكم صار فيه deformation الـ Value is + +403 +00:30:40,940 --> 00:30:43,740 +called modulus of elasticity أو الـ Young's modulus + +404 +00:30:43,740 --> 00:30:50,060 +في عندنا normal loads لـ tension and compression + +405 +00:30:50,060 --> 00:30:56,360 +وفي عندنا لـ shear كمان برضه Young's modulus + +406 +00:30:57,350 --> 00:31:00,290 +نتوجه إلى الـ two types of stiffness of modulus الـ + +407 +00:31:00,290 --> 00:31:03,550 +normal modulus for normal load هي عبارة عن الـ ratio + +408 +00:31:03,550 --> 00:31:07,590 +بين الـ stress الـ normal stress على الـ normal + +409 +00:31:07,590 --> 00:31:11,290 +strain وmeasured by Pascal والـ shear برضه هو الـ + +410 +00:31:11,290 --> 00:31:14,110 +ratio between the shear stress and the shear + +411 +00:31:14,110 --> 00:31:20,350 +strain measured in Pascal، الـ Young's modulus عبارة عن + +412 +00:31:20,350 --> 00:31:24,150 +normal stress على normal strain كل ما زادت the + +413 +00:31:24,150 --> 00:31:27,590 +higher the value of the modulus of elasticity طبعا + +414 +00:31:27,590 --> 00:31:29,570 +تكون المادة صلبة