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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Kinetic parameter </b> </td> <td> <b> ND </b> </td> <td> <b> D </b> </td> <td> <b> D + dn-RhoA </b> </td> <td> <b> D + dn-Rac1 </b> </td> </tr> </thead> <tbody> <tr> <td> Vmax </td> <td> 19.6 ± 0.75 </td> <td> 26.2 ± 0.86* </td> <td> 31.3 ± 0.88 <sup> † </sup> </td> <td> 21.6 ± 0.9 </td> </tr> <tr> <td> K' for H <sup> + </sup> </td> <td> 0.150 ± 0.02 </td> <td> 0.113 ± 0.05 <sup> † </sup> </td> <td> 0.105 ± 0.07 <sup> † </sup> </td> <td> 0.137 ± 0.023 </td> </tr> <tr> <td> n <sub> app </sub> </td> <td> 2.19 </td> <td> 2.16 </td> <td> 2.03 </td> <td> 2.23 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Characteristic </b> </td> <td> <b> Cases (n = 1125) </b> </td> <td> <b> Controls (n = 1197) </b> </td> <td> <b> P-value <sup> a </sup> </b> </td> </tr> </thead> <tbody> <tr> <td> Demographic factors </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Age (years [mean ± SD]) </td> <td> 47.63 ± 8.00 </td> <td> 47.20 ± 8.78 </td> <td> 0.217 </td> </tr> <tr> <td> Education, lower than middle school (%) </td> <td> 12.27 </td> <td> 14.79 </td> <td> 0.124 </td> </tr> <tr> <td> Major risk factors </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Breast cancer in first-degree relatives (%) </td> <td> 3.38 </td> <td> 2.26 </td> <td> 0.101 </td> </tr> <tr> <td> Ever had breast fibroadenoma (%) </td> <td> 9.78 </td> <td> 5.26 </td> <td> &lt; 0.001 </td> </tr> <tr> <td> Age at menarche (years [mean ± SD]) </td> <td> 14.41 ± 1.64 </td> <td> 14.71 ± 1.73 </td> <td> 0.004 </td> </tr> <tr> <td> Age at first live birth <sup> b </sup> (years [mean ± SD]) </td> <td> 26.82 ± 4.07 </td> <td> 26.17 ± 3.83 </td> <td> &lt; 0.001 </td> </tr> <tr> <td> Age at menopause <sup> c </sup> (years [mean ± SD]) </td> <td> 48.17 ± 4.65 </td> <td> 47.46 ± 4.95 </td> <td> 0.036 </td> </tr> <tr> <td> Physically active in past 10 years (%) </td> <td> 19.40 </td> <td> 26.00 </td> <td> &lt; 0.001 </td> </tr> <tr> <td> Body mass index (mean ± SD) </td> <td> 23.54 ± 3.39 </td> <td> 23.25 ± 3.45 </td> <td> 0.047 </td> </tr> <tr> <td> Waist-to-hip ratio (mean ± SD) </td> <td> 0.81 ± 0.06 </td> <td> 0.80 ± 0.06 </td> <td> 0.004 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Genotype </b> </td> <td> <b> Cases ( <i> n </i> [%]) </b> </td> <td> <b> Controls ( <i> n </i> [%]) </b> </td> <td> <b> OR <sup> a </sup> </b> </td> <td> <b> 95% CI </b> </td> </tr> </thead> <tbody> <tr> <td colspan="5"> <b> All subjects </b> </td> </tr> <tr> <td> Val/Val </td> <td> 831 (73.9) </td> <td> 884 (73.9) </td> <td> 1.0 </td> <td> Reference </td> </tr> <tr> <td> Val/Ala </td> <td> 266 (23.6) </td> <td> 290 (24.2) </td> <td> 1.0 </td> <td> 0.8–1.2 </td> </tr> <tr> <td> Ala/Ala </td> <td> 28 (2.5) </td> <td> 23 (1.9) </td> <td> 1.3 </td> <td> 0.7–2.3 </td> </tr> <tr> <td> Val/Val and Val/Ala </td> <td> 1097 (97.5) </td> <td> 1174 (98.1) </td> <td> 1.0 </td> <td> Reference </td> </tr> <tr> <td> Ala/Ala </td> <td> 28 (2.5) </td> <td> 23 (1.9) </td> <td> 1.3 </td> <td> 0.7–2.3 </td> </tr> <tr> <td colspan="5"> <b> Stratified analyses by menopausal status </b> </td> </tr> <tr> <td> Premenopausal women </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Val/Val and Val/Ala </td> <td> 729 (97.2) </td> <td> 751 (98.4) </td> <td> 1.0 </td> <td> Reference </td> </tr> <tr> <td> Ala/Ala </td> <td> 21 (2.8) </td> <td> 12 (1.6) </td> <td> 1.8 </td> <td> 0.9–3.7 </td> </tr> <tr> <td> Postmenopausal women </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Val/Val and Val/Ala </td> <td> 363 (98.1) </td> <td> 419 (97.4) </td> <td> 1.0 </td> <td> Reference </td> </tr> <tr> <td> Ala/Ala </td> <td> 7 (1.9) </td> <td> 11 (2.6) </td> <td> 0.8 </td> <td> 0.3–2.0 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> <i> P </i> for interaction = 0.147 </td> <td> </td> </tr> <tr> <td colspan="5"> <b> Stratified analyses by age </b> </td> </tr> <tr> <td> Age &lt; 45 years </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Val/Val and Val/Ala </td> <td> 442 (97.1) </td> <td> 488 (98.4) </td> <td> 1.0 </td> <td> Reference </td> </tr> <tr> <td> Ala/Ala </td> <td> 13 (2.9) </td> <td> 8 (1.6) </td> <td> 1.8 </td> <td> 0.7–4.3 </td> </tr> <tr> <td> Age ≥ 45 years </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Val/Val and Val/Ala </td> <td> 655 (97.8) </td> <td> 686 (97.9) </td> <td> 1.0 </td> <td> Reference </td> </tr> <tr> <td> Ala/Ala </td> <td> 15 (2.2) </td> <td> 15 (2.1) </td> <td> 1.1 </td> <td> 0.5–2.2 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> <i> P </i> for interaction = 0.380 </td> <td> </td> </tr> </tbody> </table> </body> </html>
train
87,275
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Total PCBs <sup> a </sup> </b> </td> <td> <b> <i> CYP1A1 </i> M3 genotype </b> </td> <td colspan="2"> <b> All participants </b> </td> <td colspan="2"> <b> Premenopausal </b> </td> <td colspan="2"> <b> Postmenopausal </b> </td> </tr> </thead> <tbody> <tr> <td> </td> <td> </td> <td> Patients/controls </td> <td> OR (95% CI) <sup> b </sup> </td> <td> Patients/controls </td> <td> OR (95% CI) <sup> b </sup> </td> <td> Patients/controls </td> <td> OR (95% CI) <sup> b </sup> </td> </tr> <tr> <td> &lt;0.430 </td> <td> Non-M3 </td> <td> 95/95 </td> <td> Referent </td> <td> 73/70 </td> <td> Referent </td> <td> 22/25 </td> <td> Referent </td> </tr> <tr> <td> ≥0.430 </td> <td> Non-M3 </td> <td> 105/100 </td> <td> 1.3 (0.8–2.0) </td> <td> 31/24 </td> <td> 1.6 (0.8–3.2) </td> <td> 74/76 </td> <td> 1.0 (0.5–2.0) </td> </tr> <tr> <td> &lt;0.430 </td> <td> Any M3 </td> <td> 13/26 </td> <td> 0.6 (0.3–1.2) </td> <td> 8/14 </td> <td> 0.7 (0.3–1.7) </td> <td> 5/12 </td> <td> 0.5 (0.2–1.6) </td> </tr> <tr> <td> ≥0.430 </td> <td> Any M3 </td> <td> 29/21 </td> <td> 1.6 (0.8–3.2) </td> <td> 7/6 </td> <td> 1.5 (0.5–4.7) </td> <td> 22/15 </td> <td> 1.5 (0.6–3.6) </td> </tr> <tr> <td> ICR (95% CI) </td> <td> </td> <td> </td> <td> 0.8 (-0.3,1.9) </td> <td> </td> <td> 0.2 (-1.7,2.1) </td> <td> </td> <td> 1.0 (-0.2,2.1) </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Patient </b> </td> <td> <b> Age (years) </b> </td> <td> <b> Histology </b> </td> <td> <b> Grade of invasive carcinoma (IDC/ILC) </b> </td> <td> <b> Size of IDC/ILC (cm) </b> </td> <td> <b> Type of DCIS/LCIS </b> </td> <td> <b> Size of DCIS/LCIS (cm) </b> </td> <td> <b> Mammography with suspicious microcalcifications </b> </td> <td colspan="4"> <b> Scintimammography </b> </td> <td> <b> Stromal reaction </b> </td> <td> <b> Lymphocytic infiltration </b> </td> <td> <b> <i> p53 </i> (%) </b> </td> <td> <b> c- <i> erb B-2 </i> (%) </b> </td> <td> <b> Ki-67 (%) </b> </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td colspan="2"> <b> <sup> 99m </sup> Tc-(V) DMSA </b> </td> <td colspan="2"> <b> <sup> 99m </sup> Tc-Sestamibi </b> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> <b> Focal uptake </b> </td> <td> <b> Diffuse uptake </b> </td> <td> <b> Focal uptake </b> </td> <td> <b> Diffuse uptake </b> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> </thead> <tbody> <tr> <td> 1 </td> <td> 50 </td> <td> IDC + DCIS </td> <td> II </td> <td> 6.0 </td> <td> Comedo </td> <td> 5.0 </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> - </td> <td> - </td> <td> 8 </td> <td> 8 </td> <td> 50 </td> </tr> <tr> <td> 2 </td> <td> 58 </td> <td> IDC + DCIS </td> <td> III </td> <td> 2.5 </td> <td> Comedo </td> <td> 5.0 </td> <td> (-) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (-) </td> <td> - </td> <td> - </td> <td> 0 </td> <td> 0 </td> <td> 25 </td> </tr> <tr> <td> 3 </td> <td> 49 </td> <td> IDC + DCIS </td> <td> I </td> <td> 1.0 </td> <td> Comedo </td> <td> 6.0 </td> <td> (+) </td> <td> (-) </td> <td> (+) </td> <td> (-) </td> <td> (-) </td> <td> ++ </td> <td> - </td> <td> 0 </td> <td> 20 </td> <td> 55 </td> </tr> <tr> <td> 4 </td> <td> 65 </td> <td> IDC + DCIS </td> <td> II </td> <td> 5.0 </td> <td> Comedo </td> <td> 9.0 </td> <td> (-) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> - </td> <td> - </td> <td> 10 </td> <td> 50 </td> <td> 35 </td> </tr> <tr> <td> 5 </td> <td> 54 </td> <td> IDC + DCIS </td> <td> II </td> <td> 5.0 </td> <td> Comedo </td> <td> 7.0 </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> - </td> <td> - </td> <td> 0 </td> <td> 50 </td> <td> 45 </td> </tr> <tr> <td> 6 </td> <td> 48 </td> <td> IDC + DCIS </td> <td> II </td> <td> 2.5 </td> <td> Solid </td> <td> 5.0 </td> <td> (-) </td> <td> (+) </td> <td> (+) </td> <td> (-) </td> <td> (-) </td> <td> ++ </td> <td> + </td> <td> 0 </td> <td> 0 </td> <td> 15 </td> </tr> <tr> <td> 7 </td> <td> 77 </td> <td> IDC + DCIS </td> <td> III </td> <td> 3.0 </td> <td> Comedo + cribriform </td> <td> 4.0 </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (-) </td> <td> + </td> <td> - </td> <td> 0 </td> <td> 0 </td> <td> 35 </td> </tr> <tr> <td> 8 </td> <td> 40 </td> <td> IDC + DCIS </td> <td> II </td> <td> 1.5/1.8/2.0 (multifocal) </td> <td> Comedo </td> <td> 6.0 </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (-) </td> <td> + </td> <td> - </td> <td> 10 </td> <td> 10 </td> <td> 10 </td> </tr> <tr> <td> 9 </td> <td> 50 </td> <td> DCIS </td> <td> </td> <td> </td> <td> Comedo </td> <td> 0.8 </td> <td> (-) </td> <td> (-) </td> <td> (-) </td> <td> (-) </td> <td> (-) </td> <td> - </td> <td> - </td> <td> 8 </td> <td> 15 </td> <td> 32 </td> </tr> <tr> <td> 10 </td> <td> 53 </td> <td> IDC + DCIS </td> <td> II </td> <td> 1.5 </td> <td> Comedo </td> <td> 4.0 </td> <td> (-) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> - </td> <td> - </td> <td> 25 </td> <td> 0 </td> <td> 35 </td> </tr> <tr> <td> 11 </td> <td> 86 </td> <td> IDC + DCIS </td> <td> III </td> <td> 2.0 </td> <td> Comedo </td> <td> 3.0 </td> <td> (-) </td> <td> (+) </td> <td> (+) </td> <td> Not performed </td> <td> </td> <td> - </td> <td> - </td> <td> 0 </td> <td> 0 </td> <td> 42 </td> </tr> <tr> <td> 12 </td> <td> 66 </td> <td> DCIS </td> <td> </td> <td> </td> <td> - </td> <td> 3.0 </td> <td> (-) </td> <td> (-) </td> <td> (+) </td> <td> Not performed </td> <td> </td> <td> - </td> <td> - </td> <td> 0 </td> <td> 0 </td> <td> 35 </td> </tr> <tr> <td> 13 </td> <td> 71 </td> <td> IDC + DCIS </td> <td> II </td> <td> 0.7 </td> <td> Cribriform </td> <td> 8.0 </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> Not performed </td> <td> </td> <td> +++ </td> <td> + </td> <td> 0 </td> <td> 80 </td> <td> 55 </td> </tr> <tr> <td> 14 </td> <td> 60 </td> <td> IDC + DCIS </td> <td> II </td> <td> 2.9 </td> <td> Comedo + micropapillary </td> <td> 5.0 </td> <td> (-) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> - </td> <td> - </td> <td> 27 </td> <td> 75 </td> <td> 15 </td> </tr> <tr> <td> 15 </td> <td> 50 </td> <td> IDC + DCIS </td> <td> II </td> <td> 2.0 </td> <td> Micropapillary </td> <td> 2.0 </td> <td> (-) </td> <td> Not performed </td> <td> </td> <td> (+) </td> <td> (+) </td> <td> - </td> <td> - </td> <td> 0 </td> <td> 0 </td> <td> 31 </td> </tr> <tr> <td> 16 </td> <td> 38 </td> <td> IDC + DCIS </td> <td> III </td> <td> 4.3 </td> <td> Comedo </td> <td> 4.0 </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> Not performed </td> <td> </td> <td> + </td> <td> ++ </td> <td> 0 </td> <td> 50 </td> <td> 45 </td> </tr> <tr> <td> 17 </td> <td> 61 </td> <td> DCIS </td> <td> </td> <td> </td> <td> Comedo + solid </td> <td> 5.0 </td> <td> (+) </td> <td> (-) </td> <td> (+) </td> <td> Not performed </td> <td> </td> <td> - </td> <td> - </td> <td> 20 </td> <td> 10 </td> <td> 15 </td> </tr> <tr> <td> 18 </td> <td> 71 </td> <td> DCIS </td> <td> </td> <td> </td> <td> Comedo + solid + cribriform </td> <td> 4.5 </td> <td> (+) </td> <td> (-) </td> <td> (+) </td> <td> Not performed </td> <td> </td> <td> - </td> <td> - </td> <td> 13 </td> <td> 40 </td> <td> 35 </td> </tr> <tr> <td> 19 </td> <td> 67 </td> <td> ILC + LCIS </td> <td> II </td> <td> 2.5 </td> <td> </td> <td> 6.0 </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> Not performed </td> <td> </td> <td> ++ </td> <td> - </td> <td> 0 </td> <td> 0 </td> <td> 20 </td> </tr> <tr> <td> 20 </td> <td> 65 </td> <td> ILC + LCIS </td> <td> III </td> <td> 4.0 </td> <td> </td> <td> 6.0 </td> <td> (-) </td> <td> (+) </td> <td> (+) </td> <td> (+) </td> <td> (-) </td> <td> ++ </td> <td> ++ </td> <td> 6 </td> <td> 25 </td> <td> 38 </td> </tr> </tbody> </table> </body> </html>
train
290,006
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Culture </b> </td> <td> <b> BrdU-labeling indices of MCF10A cells (mean ± standard error of the mean) </b> </td> <td> <b> BrdU-labeling indices of MCF10A cells (group mean ± standard error of the mean) </b> </td> <td colspan="2"> <b> Comparison of BrdU-labeling indices of MCF10A cells between groups (linear regression) </b> </td> </tr> </thead> <tbody> <tr> <td> MCF10A ( <i> n </i> = 6) </td> <td> 30.3 ± 3.0 </td> <td> 30.3 ± 3.0 </td> <td> MCF10A vs MCF10A + NAF ( <i> P </i> = 0.009) </td> <td> MCF10A + NAF vs MCF10A + CAF ( <i> P </i> = 0.501) </td> </tr> <tr> <td> NAF-1 + MCF10A ( <i> n </i> = 7) </td> <td> 21.9 ± 4.2 </td> <td> 16.1 ± 2.6 ( <i> n </i> = 19) </td> <td> </td> <td> </td> </tr> <tr> <td> NAF-2 + MCF10A ( <i> n </i> = 6) </td> <td> 10.7 ± 3.6 </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> NAF-3 + MCF10A ( <i> n </i> = 6) </td> <td> 14.7 ± 5.0 </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CAF-1 + MCF10A ( <i> n </i> = 8) </td> <td> 15.2 ± 2.0 </td> <td> 18.5 ± 2.5 ( <i> n </i> = 19) </td> <td> MCF10A vs MCF10A + CAF ( <i> P </i> = 0.024) </td> <td> </td> </tr> <tr> <td> CAF-2 + MCF10A ( <i> n </i> = 6) </td> <td> 15.5 ± 4.2 </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CAF-3 + MCF10A ( <i> n </i> = 5) </td> <td> 27.6 ± 6.7 </td> <td> </td> <td> </td> <td> </td> </tr> </tbody> </table> </body> </html>
train
320,713
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Cell type </b> </td> <td colspan="4"> <b> IGF II level (normalized to total protein) </b> </td> </tr> <tr> <td> </td> <td colspan="2"> <b> Monoculture </b> </td> <td colspan="2"> <b> Co-culture with MCF10AT cells </b> </td> </tr> <tr> <td> </td> <td> <b> Level (ng/μg) </b> </td> <td> <b> Mean (ng/μg) </b> </td> <td> <b> Level (ng/μg) </b> </td> <td> <b> Mean (ng/μg) </b> </td> </tr> </thead> <tbody> <tr> <td> NAF </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> NAF-1 </td> <td> 49.25 </td> <td> </td> <td> 9.68 </td> <td> </td> </tr> <tr> <td> NAF-2 </td> <td> 45.00 </td> <td> </td> <td> 10.22 </td> <td> </td> </tr> <tr> <td> NAF-3 </td> <td> 68.14 </td> <td> 54.13 </td> <td> 10.27 </td> <td> 10.06 </td> </tr> <tr> <td> CAF </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CAF-1 </td> <td> 70.64 </td> <td> </td> <td> 10.01 </td> <td> </td> </tr> <tr> <td> CAF-2 </td> <td> 52.37 </td> <td> </td> <td> 10.88 </td> <td> </td> </tr> <tr> <td> CAF-3 </td> <td> 52.96 </td> <td> 58.65 </td> <td> 9.96 </td> <td> 10.28 </td> </tr> <tr> <td colspan="5"> Breast epithelial cells </td> </tr> <tr> <td> MCF10AT </td> <td> 9.98 </td> <td> </td> <td> </td> <td> </td> </tr> </tbody> </table> </body> </html>
train
307,692
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="2"> <b> Mothers </b> </td> <td colspan="2"> <b> Daughters </b> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> <b> Genotype </b> </td> <td> <b> Affected </b> </td> <td> <b> Unaffected </b> </td> <td> <b> Affected </b> </td> <td> <b> Unaffected </b> </td> <td> <b> Fathers </b> </td> <td> <b> Sons </b> </td> <td> <b> Total </b> </td> </tr> </thead> <tbody> <tr> <td> <i> CYP17 </i> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CC </td> <td> 2 </td> <td> 10 </td> <td> 47 </td> <td> 41 </td> <td> 6 </td> <td> 11 </td> <td> 117 </td> </tr> <tr> <td> CT </td> <td> 8 </td> <td> 32 </td> <td> 147 </td> <td> 108 </td> <td> 30 </td> <td> 22 </td> <td> 347 </td> </tr> <tr> <td> TT </td> <td> 2 </td> <td> 19 </td> <td> 107 </td> <td> 61 </td> <td> 8 </td> <td> 18 </td> <td> 215 </td> </tr> <tr> <td> Unknown </td> <td> 64 </td> <td> 140 </td> <td> 0 </td> <td> 0 </td> <td> 233 </td> <td> 0 </td> <td> 437 </td> </tr> <tr> <td> Total </td> <td> 76 </td> <td> 201 </td> <td> 301 </td> <td> 210 </td> <td> 277 </td> <td> 51 </td> <td> 1116 </td> </tr> <tr> <td> <i> CYP19 </i> (no. of TTTA repeats) </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> 7/7 </td> <td> 1 </td> <td> 15 </td> <td> 88 </td> <td> 55 </td> <td> 7 </td> <td> 21 </td> <td> 187 </td> </tr> <tr> <td> 7/8 </td> <td> 0 </td> <td> 10 </td> <td> 34 </td> <td> 29 </td> <td> 4 </td> <td> 5 </td> <td> 82 </td> </tr> <tr> <td> 7/9 </td> <td> 0 </td> <td> 0 </td> <td> 1 </td> <td> 0 </td> <td> 1 </td> <td> 0 </td> <td> 2 </td> </tr> <tr> <td> 7/10 </td> <td> 0 </td> <td> 1 </td> <td> 5 </td> <td> 6 </td> <td> 2 </td> <td> 0 </td> <td> 14 </td> </tr> <tr> <td> 7/11 </td> <td> 9 </td> <td> 19 </td> <td> 106 </td> <td> 71 </td> <td> 14 </td> <td> 19 </td> <td> 238 </td> </tr> <tr> <td> 7/12 </td> <td> 0 </td> <td> 2 </td> <td> 9 </td> <td> 8 </td> <td> 0 </td> <td> 0 </td> <td> 19 </td> </tr> <tr> <td> 7/13 </td> <td> 0 </td> <td> 0 </td> <td> 0 </td> <td> 0 </td> <td> 1 </td> <td> 0 </td> <td> 1 </td> </tr> <tr> <td> 8/8 </td> <td> 0 </td> <td> 0 </td> <td> 4 </td> <td> 1 </td> <td> 0 </td> <td> 0 </td> <td> 5 </td> </tr> <tr> <td> 8/10 </td> <td> 0 </td> <td> 1 </td> <td> 3 </td> <td> 2 </td> <td> 0 </td> <td> 0 </td> <td> 6 </td> </tr> <tr> <td> 8/11 </td> <td> 1 </td> <td> 2 </td> <td> 24 </td> <td> 16 </td> <td> 1 </td> <td> 3 </td> <td> 47 </td> </tr> <tr> <td> 8/12 </td> <td> 0 </td> <td> 0 </td> <td> 1 </td> <td> 2 </td> <td> 0 </td> <td> 0 </td> <td> 3 </td> </tr> <tr> <td> 8/13 </td> <td> 0 </td> <td> 0 </td> <td> 0 </td> <td> 1 </td> <td> 0 </td> <td> 0 </td> <td> 1 </td> </tr> <tr> <td> 9/11 </td> <td> 0 </td> <td> 0 </td> <td> 0 </td> <td> 1 </td> <td> 0 </td> <td> 0 </td> <td> 1 </td> </tr> <tr> <td> 10/11 </td> <td> 0 </td> <td> 0 </td> <td> 2 </td> <td> 3 </td> <td> 0 </td> <td> 2 </td> <td> 7 </td> </tr> <tr> <td> 11/11 </td> <td> 0 </td> <td> 5 </td> <td> 19 </td> <td> 16 </td> <td> 1 </td> <td> 1 </td> <td> 42 </td> </tr> <tr> <td> 11/12 </td> <td> 0 </td> <td> 1 </td> <td> 4 </td> <td> 2 </td> <td> 0 </td> <td> 0 </td> <td> 7 </td> </tr> <tr> <td> 11/13 </td> <td> 1 </td> <td> 0 </td> <td> 2 </td> <td> 1 </td> <td> 1 </td> <td> 0 </td> <td> 5 </td> </tr> <tr> <td> 11/not 11 <sup> a </sup> </td> <td> 1 </td> <td> 3 </td> <td> 0 </td> <td> 0 </td> <td> 5 </td> <td> 0 </td> <td> 9 </td> </tr> <tr> <td> Unknown </td> <td> 63 </td> <td> 143 </td> <td> 0 </td> <td> 0 </td> <td> 241 </td> <td> 0 </td> <td> 447 </td> </tr> <tr> <td> Total </td> <td> 76 </td> <td> 202 </td> <td> 302 </td> <td> 214 </td> <td> 278 </td> <td> 51 </td> <td> 1123 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td> </td> <td colspan="3"> <b> Nonfounder statistic </b> </td> <td colspan="3"> <b> Founder statistic </b> </td> </tr> <tr> <td> <b> Variant allele(s) </b> </td> <td> <b> Estimated allele frequency (%) </b> </td> <td> <b> Recessive model </b> </td> <td> <b> Dominant model </b> </td> <td> <b> Additive model </b> </td> <td> <b> Recessive model </b> </td> <td> <b> Dominant model </b> </td> <td> <b> Additive model </b> </td> </tr> </thead> <tbody> <tr> <td> <i> CYP17 </i> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> C </td> <td> 42.46 </td> <td> - 1.01 </td> <td> - 1.52 </td> <td> - 1.85 </td> <td> 0.40 </td> <td> 1.08 </td> <td> 1.01 </td> </tr> <tr> <td> <i> P </i> </td> <td> </td> <td> 0.16 </td> <td> 0.06 </td> <td> 0.03 </td> <td> 0.34 </td> <td> 0.14 </td> <td> 0.16 </td> </tr> <tr> <td> <i> CYP19 </i> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> (TTTA) <sub> ≥10 </sub> </td> <td> 33.71 </td> <td> - 1.24 </td> <td> 1.26 </td> <td> 0.32 </td> <td> - 0.32 </td> <td> <b> 1.66 </b> </td> <td> 1.13 </td> </tr> <tr> <td> <i> P </i> </td> <td> </td> <td> 0.11 </td> <td> 0.10 </td> <td> 0.38 </td> <td> 0.37 </td> <td> 0.05 </td> <td> 0.13 </td> </tr> <tr> <td> (TTTA) <sub> 11 </sub> </td> <td> 28.78 </td> <td> - 1.09 </td> <td> <b> 1.83 </b> </td> <td> 0.97 </td> <td> - 1.50 </td> <td> <b> 1.96 </b> </td> <td> 0.89 </td> </tr> <tr> <td> <i> P </i> </td> <td> </td> <td> 0.14 </td> <td> 0.03 </td> <td> 0.17 </td> <td> 0.07 </td> <td> 0.03 </td> <td> 0.19 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Gene (sibling sets/cases/controls) </b> </td> <td> </td> <td> <b> Affected ( <i> n </i> ) </b> </td> <td> <b> Unaffected ( <i> n </i> ) </b> </td> <td> <b> Adjusted odds ratios for breast cancer (95% CI) </b> </td> </tr> </thead> <tbody> <tr> <td> <i> CYP17 </i> (165/171/188) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Dominant model </td> <td> TT </td> <td> 59 </td> <td> 56 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> TC/CC </td> <td> 112 </td> <td> 132 </td> <td> 0.86 (0.47–1.59) </td> </tr> <tr> <td> Recessive model </td> <td> TC/TT </td> <td> 146 </td> <td> 154 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> CC </td> <td> 25 </td> <td> 34 </td> <td> 0.61 (0.27–1.41) </td> </tr> <tr> <td> General model </td> <td> TT </td> <td> 59 </td> <td> 56 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> TC </td> <td> 87 </td> <td> 98 </td> <td> 0.86 (0.47–1.59) </td> </tr> <tr> <td> </td> <td> CC </td> <td> 25 </td> <td> 34 </td> <td> 0.55 (0.21–1.42) </td> </tr> <tr> <td colspan="4"> Additive model (trend per allele) </td> <td> 0.77 (0.49–1.21) </td> </tr> <tr> <td colspan="5"> <i> CYP19 </i> (no. of TTTA repeats) (169/175/193) </td> </tr> <tr> <td> Dominant model </td> <td> (TTTA) <sub> &lt;10 </sub> (TTTA) <sub> &lt;10 </sub> </td> <td> 67 </td> <td> 78 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> ≥10 </sub> (TTTA) <sub> &lt;10 </sub> /(TTTA) <sub> ≥10 </sub> (TTTA) <sub> ≥10 </sub> </td> <td> 108 </td> <td> 115 </td> <td> 1.24 (0.63–2.46) </td> </tr> <tr> <td> Recessive model </td> <td> (TTTA) <sub> &lt;10 </sub> (TTTA) <sub> &lt;10 </sub> /(TTTA) <sub> ≥10 </sub> (TTTA) <sub> &lt;10 </sub> </td> <td> 159 </td> <td> 173 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> ≥10 </sub> (TTTA) <sub> ≥10 </sub> </td> <td> 16 </td> <td> 20 </td> <td> 0.82 (0.30–2.24) </td> </tr> <tr> <td> General model </td> <td> (TTTA) <sub> &lt;10 </sub> (TTTA) <sub> &lt;10 </sub> </td> <td> 67 </td> <td> 78 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> ≥10 </sub> (TTTA) <sub> &lt;10 </sub> </td> <td> 92 </td> <td> 95 </td> <td> 1.26 (0.64–2.51) </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> ≥10 </sub> (TTTA) <sub> ≥10 </sub> </td> <td> 16 </td> <td> 20 </td> <td> 0.98 (0.30–3.18) </td> </tr> <tr> <td colspan="4"> Additive model (trend per allele) </td> <td> 1.11 (0.65–1.89) </td> </tr> <tr> <td> Dominant model </td> <td> (TTTA) <sub> other </sub> (TTTA) <sub> other </sub> </td> <td> 77 </td> <td> 95 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> 11 </sub> (TTTA) <sub> other </sub> /(TTTA) <sub> 11 </sub> (TTTA) <sub> 11 </sub> </td> <td> 98 </td> <td> 98 </td> <td> 1.77 (0.90–3.47) </td> </tr> <tr> <td> Recessive model </td> <td> (TTTA) <sub> other </sub> (TTTA) <sub> other </sub> /(TTTA) <sub> 11 </sub> (TTTA) <sub> other </sub> </td> <td> 165 </td> <td> 179 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> 11 </sub> (TTTA) <sub> 11 </sub> </td> <td> 10 </td> <td> 14 </td> <td> 0.66 (0.19–2.33) </td> </tr> <tr> <td> General model </td> <td> (TTTA) <sub> other </sub> (TTTA) <sub> other </sub> </td> <td> 77 </td> <td> 95 </td> <td> 1.00 </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> 11 </sub> (TTTA) <sub> other </sub> </td> <td> 88 </td> <td> 84 </td> <td> 1.84 (0.93–3.63) </td> </tr> <tr> <td> </td> <td> (TTTA) <sub> 11 </sub> (TTTA) <sub> 11 </sub> </td> <td> 10 </td> <td> 14 </td> <td> 1.04 (0.27–4.08) </td> </tr> <tr> <td colspan="4"> Additive model (trend per allele) </td> <td> 1.38 (0.79–2.40) </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="4"> <b> Test statistic </b> </td> </tr> <tr> <td> </td> <td colspan="2"> <b> Mothers' carrier status and disease risk in daughters </b> </td> <td colspan="2"> <b> Fathers' carrier status and disease risk in daughters </b> </td> </tr> <tr> <td> <b> Variant allele(s) </b> </td> <td> <b> Additive </b> </td> <td> <b> Dominant </b> </td> <td> <b> Additive </b> </td> <td> <b> Dominant </b> </td> </tr> </thead> <tbody> <tr> <td> <i> CYP17 </i> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> C </td> <td> 1.47 </td> <td> 1.09 </td> <td> 1.40 </td> <td> 1.07 </td> </tr> <tr> <td> <i> P </i> </td> <td> 0.07 </td> <td> 0.14 </td> <td> 0.08 </td> <td> 0.14 </td> </tr> <tr> <td> <i> CYP19 </i> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> (TTTA) <sub> ≥10 </sub> </td> <td> 1.73 </td> <td> 1.65 </td> <td> 0.95 </td> <td> 0.45 </td> </tr> <tr> <td> <i> P </i> </td> <td> 0.04 </td> <td> 0.05 </td> <td> 0.17 </td> <td> 0.33 </td> </tr> <tr> <td> (TTTA) <sub> 11 </sub> </td> <td> 1.52 </td> <td> 1.96 </td> <td> - 0.11 </td> <td> 0.18 </td> </tr> <tr> <td> <i> P </i> </td> <td> 0.06 </td> <td> 0.03 </td> <td> 0.46 </td> <td> 0.43 </td> </tr> </tbody> </table> </body> </html>
train
308,016
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="2"> <b> Odds ratio (95% confidence interval, <i> P </i> ) </b> </td> </tr> <tr> <td> <b> Feature </b> </td> <td> <b> <i> BRCA1 </i> </b> </td> <td> <b> <i> BRCA2 </i> </b> </td> </tr> </thead> <tbody> <tr> <td> First step: </td> <td> </td> <td> </td> </tr> <tr> <td> Age (continuous) </td> <td> 0.94 (0.91–0.98, 0.0009) </td> <td> 0.94 (0.91–0.97, 0.0001) </td> </tr> <tr> <td> Grade (continuous) </td> <td> 3.78 (1.70–8.39, 0.0011) </td> <td> 1.27 (0.71–2.26, 0.42) </td> </tr> <tr> <td> ER <sup> + </sup> </td> <td> 1.0 (referent) </td> <td> 1.0 (referent) </td> </tr> <tr> <td> ER <sup> - </sup> </td> <td> 0.91 (0.28–2.90, 0.88) </td> <td> 0.85 (0.32–2.29, 0.75) </td> </tr> <tr> <td> PgR <sup> + </sup> </td> <td> 1.0 (referent) </td> <td> 1.0 (referent) </td> </tr> <tr> <td> PgR <sup> - </sup> </td> <td> 4.18 (1.26–13.87, 0.019) </td> <td> 1.82 (0.75–4.38, 0.18) </td> </tr> <tr> <td> p53 <sup> + </sup> </td> <td> 1.0 (referent) </td> <td> 1.0 (referent) </td> </tr> <tr> <td> p53 <sup> - </sup> </td> <td> 1.96 (0.74–5.18, 0.18) </td> <td> 1.61 (0.63–4.12, 0.34) </td> </tr> <tr> <td> Final step after stepwise regression: </td> <td> </td> <td> </td> </tr> <tr> <td> Age (continuous) </td> <td> 0.94 (0.92–0.98, 0.0012) </td> <td> 0.94 (0.92–0.97, 0.0001) </td> </tr> <tr> <td> Grade (continuous) </td> <td> 3.25 (1.58–6.69, 0.0014) </td> <td> </td> </tr> <tr> <td> PgR <sup> + </sup> </td> <td> 1.0 (referent) </td> <td> </td> </tr> <tr> <td> PgR <sup> - </sup> </td> <td> 3.45 (1.22–9.80, 0.02) </td> <td> </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Genotypes </b> </td> <td colspan="2"> <b> <i> p53 </i> <sup> +/- </sup> </b> </td> <td colspan="2"> <b> <i> p </i> 53 <sup> +/+ </sup> </b> </td> </tr> <tr> <td> </td> <td> <b> <i> Atm </i> <sup> +/- </sup> ( <i> n </i> = 28) </b> </td> <td> <b> <i> Atm </i> <sup> +/+ </sup> ( <i> n </i> = 22) </b> </td> <td> <b> <i> Atm </i> <sup> +/- </sup> ( <i> n </i> = 11) </b> </td> <td> <b> <i> Atm </i> <sup> +/+ </sup> ( <i> n </i> = 25) </b> </td> </tr> </thead> <tbody> <tr> <td> Mammary carcinoma </td> <td> 14 (50%) <sup> a </sup> </td> <td> 7 (32%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Lymphoma </td> <td> 3 (11%) </td> <td> 3 (14%) </td> <td> 2 (18%) </td> <td> 4 (16%) </td> </tr> <tr> <td> Ovarian carcinoma </td> <td> 1 (4%) </td> <td> 1 (5%) </td> <td> 0 (0%) </td> <td> 1 (4%) </td> </tr> <tr> <td> Osteosarcoma </td> <td> 1 (4%) </td> <td> 0(0%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Hepatoma </td> <td> 1 (4%) </td> <td> 0(0%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Number of mammary carcinomas/mouse <sup> b </sup> </td> <td> 14/28 (0.50) </td> <td> 7/22 (0.32) </td> <td> 0/11 (0.00) </td> <td> 0/25 (0.00) </td> </tr> </tbody> </table> </body> </html>
train
348,236
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Genotypes </b> </td> <td colspan="2"> <b> <i> p </i> 53 <sup> +/- </sup> </b> </td> <td colspan="2"> <b> <i> p53 </i> <sup> +/+ </sup> </b> </td> </tr> <tr> <td> </td> <td> <b> <i> Atm </i> <sup> +/- </sup> ( <i> n </i> = 55) </b> </td> <td> <b> <i> Atm </i> <sup> +/+ </sup> ( <i> n </i> = 61) </b> </td> <td> <b> <i> Atm </i> <sup> +/- </sup> ( <i> n </i> = 47) </b> </td> <td> <b> <i> Atm </i> <sup> +/+ </sup> ( <i> n </i> = 53) </b> </td> </tr> </thead> <tbody> <tr> <td> Mammary carcinoma </td> <td> 32 (58%) <sup> a </sup> * </td> <td> 19 (31%) </td> <td> 0 (0%) </td> <td> 1 (2%) </td> </tr> <tr> <td> Lymphoma </td> <td> 24 (44%) <sup> b </sup> </td> <td> 29 (48%) </td> <td> 26 (55%) </td> <td> 22 (42%) </td> </tr> <tr> <td> Squamous cell carcinoma </td> <td> 1 (2%) </td> <td> 1 (2%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Histiocytic sarcoma </td> <td> 1 (2%) <sup> c </sup> </td> <td> 0 (0%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Basal cell carcinoma </td> <td> 0 (0%) </td> <td> 1 (2%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Granulocytic leukaemia </td> <td> 0 (0%) </td> <td> 1 (2%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Ovarian carcinoma </td> <td> 0 (0%) </td> <td> 1 (2%) </td> <td> 0 (0%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Nonthymic lymphoma (NOS) </td> <td> 0 (0%) </td> <td> 1 (2%) </td> <td> 3 (6%) </td> <td> 0 (0%) </td> </tr> <tr> <td> Solid tumour (NOS) </td> <td> 1 (2%) <sup> d </sup> </td> <td> 1 (2%) <sup> e </sup> </td> <td> 1 (2%) </td> <td> 1 (2%) </td> </tr> <tr> <td> Number of mammary carcinomas/mouse <sup> e </sup> </td> <td> 52/55 (0.95)** </td> <td> 28/61 (0.46) </td> <td> 0/47 (0.00) </td> <td> 1/53 (0.02) </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Risk allele </b> </td> <td colspan="2"> <b> Adjusted group, ethnicity </b> </td> <td colspan="2"> <b> Adjusted group, ethnicity and additional variables </b> </td> </tr> <tr> <td> </td> <td> <b> <i> P </i> </b> </td> <td> <b> RR (95% CI) </b> </td> <td> <b> <i> P </i> </b> </td> <td> <b> RR (95% CI) </b> </td> </tr> </thead> <tbody> <tr> <td> <i> AR </i> ≥ 28 CAG </td> <td> 0.3 </td> <td> 0.74 (0.42–1.29) </td> <td> 0.6 </td> <td> 0.88 (0.53–1.46) </td> </tr> <tr> <td> <i> AR </i> ≥ 29 CAG </td> <td> 0.3 </td> <td> 0.76 (0.43–1.33) </td> <td> 0.7 </td> <td> 0.89 (0.54–1.48) </td> </tr> <tr> <td> <i> AR </i> average CAG </td> <td> 0.5 </td> <td> 1.02 (0.96–1.09) </td> <td> 0.3 </td> <td> 1.03 (0.97–1.10) </td> </tr> <tr> <td> <i> AR </i> small CAG </td> <td> 0.3 </td> <td> 1.03 (0.97–1.09) </td> <td> 0.2 </td> <td> 1.04 (0.98–1.10) </td> </tr> <tr> <td> <i> AR </i> large CAG </td> <td> 0.9 </td> <td> 1.01 (0.96–1.06) </td> <td> 0.6 </td> <td> 1.01 (0.97–1.06) </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Risk allele </b> </td> <td colspan="2"> <b> Adjusted group, ethnicity </b> </td> <td colspan="2"> <b> Adjusted group, ethnicity and additional variables </b> </td> </tr> <tr> <td> </td> <td> <b> <i> P </i> </b> </td> <td> <b> RR (95% CI) </b> </td> <td> <b> <i> P </i> </b> </td> <td> <b> RR (95% CI) </b> </td> </tr> </thead> <tbody> <tr> <td> AR ≥ 28 CAG </td> <td> 0.8 </td> <td> 1.12 (0.55–2.25) </td> <td> 0.9 </td> <td> 1.04 (0.47–2.32) </td> </tr> <tr> <td> AR ≥ 29 CAG </td> <td> 0.8 </td> <td> 0.88 (0.37–2.09) </td> <td> 0.8 </td> <td> 0.90 (0.32–2.52) </td> </tr> <tr> <td> AR average CAG </td> <td> 0.7 </td> <td> 0.98 (0.91–1.06) </td> <td> 1.0 </td> <td> 1.00 (0.92–1.09) </td> </tr> <tr> <td> AR small CAG </td> <td> 0.6 </td> <td> 0.98 (0.90–1.06) </td> <td> 1.0 </td> <td> 1.00 (0.92–1.09) </td> </tr> <tr> <td> AR large CAG </td> <td> 0.9 </td> <td> 0.99 (0.93–1.06) </td> <td> 1.0 </td> <td> 1.00 (0.93–1.07) </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="2"> <b> Women with breast implants ( <i> n </i> = 817) </b> </td> <td colspan="2"> <b> Women without breast implants ( <i> n </i> = 3568) </b> </td> <td colspan="2"> <b> Total ( <i> n </i> = 4385) </b> </td> <td> <b> <i> P </i> value <sup> a </sup> </b> </td> </tr> <tr> <td> </td> <td> <b> <i> n </i> </b> </td> <td> <b> % </b> </td> <td> <b> <i> n </i> </b> </td> <td> <b> % </b> </td> <td> <b> <i> n </i> </b> </td> <td> <b> % </b> </td> <td> </td> </tr> </thead> <tbody> <tr> <td> Alive </td> <td> 676 </td> <td> 82.3 </td> <td> 2498 </td> <td> 70.0 </td> <td> 3174 </td> <td> 72.4 </td> <td> &lt; 0.0001 </td> </tr> <tr> <td> Deceased </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> All malignant cancers </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Digestive system </td> <td> 2 </td> <td> 0.2 </td> <td> 32 </td> <td> 0.9 </td> <td> 34 </td> <td> 0.8 </td> <td> 0.08 </td> </tr> <tr> <td> Respiratory </td> <td> 3 </td> <td> 0.4 </td> <td> 51 </td> <td> 1.4 </td> <td> 54 </td> <td> 1.2 </td> <td> 0.01 </td> </tr> <tr> <td> Breast </td> <td> 101 </td> <td> 12.4 </td> <td> 703 </td> <td> 19.7 </td> <td> 804 </td> <td> 18.3 </td> <td> &lt; 0.0001 </td> </tr> <tr> <td> Female genital </td> <td> 4 </td> <td> 0.5 </td> <td> 20 </td> <td> 0.6 </td> <td> 24 </td> <td> 0.5 </td> <td> 0.80 </td> </tr> <tr> <td> Kidney </td> <td> - </td> <td> - </td> <td> 2 </td> <td> 0.1 </td> <td> 2 </td> <td> 0.2 </td> <td> - </td> </tr> <tr> <td> Brain </td> <td> - </td> <td> - </td> <td> 7 </td> <td> 0.2 </td> <td> 7 </td> <td> 0.2 </td> <td> - </td> </tr> <tr> <td> Melanoma </td> <td> 1 </td> <td> 0.1 </td> <td> 2 </td> <td> 0.1 </td> <td> 3 </td> <td> 0.1 </td> <td> 0.46 </td> </tr> <tr> <td> Multiple myeloma </td> <td> - </td> <td> - </td> <td> 3 </td> <td> 0.1 </td> <td> 3 </td> <td> 0.1 </td> <td> - </td> </tr> <tr> <td> Non-Hodgkin's lymphoma </td> <td> - </td> <td> - </td> <td> 3 </td> <td> 0.1 </td> <td> 3 </td> <td> 0.1 </td> <td> - </td> </tr> <tr> <td> Leukemia </td> <td> 2 </td> <td> 0.2 </td> <td> 2 </td> <td> 0.1 </td> <td> 4 </td> <td> 0.1 </td> <td> 0.16 </td> </tr> <tr> <td> Diabetes mellitus </td> <td> 2 </td> <td> 0.2 </td> <td> 13 </td> <td> 0.4 </td> <td> 15 </td> <td> 0.3 </td> <td> 0.60 </td> </tr> <tr> <td> Circulatory system </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Heart disease </td> <td> 4 </td> <td> 0.5 </td> <td> 65 </td> <td> 1.8 </td> <td> 69 </td> <td> 1.6 </td> <td> 0.01 </td> </tr> <tr> <td> Cerebrovascular disease </td> <td> 2 </td> <td> 0.2 </td> <td> 14 </td> <td> 0.4 </td> <td> 16 </td> <td> 0.4 </td> <td> 0.75 </td> </tr> <tr> <td> Atherosclerosis </td> <td> - </td> <td> - </td> <td> 3 </td> <td> 0.1 </td> <td> 3 </td> <td> 0.1 </td> <td> - </td> </tr> <tr> <td> Respiratory disease </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Pneumonia/influenza </td> <td> 1 </td> <td> 0.1 </td> <td> 10 </td> <td> 0.3 </td> <td> 11 </td> <td> 0.3 </td> <td> - </td> </tr> <tr> <td> Chronic obstructive pulmonary disease </td> <td> 2 </td> <td> 0.2 </td> <td> 23 </td> <td> 0.6 </td> <td> 25 </td> <td> 0.6 </td> <td> 0.21 </td> </tr> <tr> <td> Digestive system disease </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Stomach/duodenal ulcers </td> <td> - </td> <td> - </td> <td> 3 </td> <td> 0.1 </td> <td> 3 </td> <td> 0.1 </td> <td> - </td> </tr> <tr> <td> Chronic liver disease </td> <td> 1 </td> <td> 0.1 </td> <td> 7 </td> <td> 0.2 </td> <td> 8 </td> <td> 0.2 </td> <td> - </td> </tr> <tr> <td> Nephritis </td> <td> - </td> <td> - </td> <td> 7 </td> <td> 0.2 </td> <td> 7 </td> <td> 0.2 </td> <td> - </td> </tr> <tr> <td> All external causes </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Accidents </td> <td> - </td> <td> - </td> <td> 4 </td> <td> 0.1 </td> <td> 4 </td> <td> 0.3 </td> <td> - </td> </tr> <tr> <td> Suicides </td> <td> 3 </td> <td> 0.4 </td> <td> 1 </td> <td> 0.03 </td> <td> 4 </td> <td> 0.3 </td> <td> 0.02 </td> </tr> <tr> <td> Other cause of death </td> <td> 5 </td> <td> 0.6 </td> <td> 38 </td> <td> 1.1 </td> <td> 43 </td> <td> 3.6 </td> <td> 0.26 </td> </tr> <tr> <td> Unknown cause of death </td> <td> 7 </td> <td> 0.9 </td> <td> 32 </td> <td> 0.9 </td> <td> 39 </td> <td> 3.2 </td> <td> 0.91 </td> </tr> </tbody> </table> </body> </html>
train
427,530
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Characteristic </b> </td> <td> <b> Cases ( <i> n </i> = 419) </b> </td> <td> <b> Controls ( <i> n </i> = 884) </b> </td> </tr> </thead> <tbody> <tr> <td> Mean age (years) </td> <td> 42.9 </td> <td> 42.7 </td> </tr> <tr> <td> Mean body mass index </td> <td> 23.9 </td> <td> 24.3 </td> </tr> <tr> <td> First-degree family history of breast cancer </td> <td> 62 (14.8%) </td> <td> 53 (6.0%) </td> </tr> <tr> <td> Menopausal status </td> <td> </td> <td> </td> </tr> <tr> <td> Premenopausal </td> <td> 325 (77.6%) </td> <td> 718 (81.2%) </td> </tr> <tr> <td> Postmenopausal </td> <td> 25 (6.0%) </td> <td> 49 (5.5%) </td> </tr> <tr> <td> Unknown </td> <td> 69 (16.5%) </td> <td> 117 (13.2%) </td> </tr> <tr> <td> <i> SULT1A1 </i> genotype </td> <td> </td> <td> </td> </tr> <tr> <td> <i> *1 </i> / <i> *1 </i> </td> <td> 198 (47.3%) </td> <td> 374 (42.3%) </td> </tr> <tr> <td> <i> *1 </i> / <i> *2 </i> </td> <td> 169 (40.3%) </td> <td> 403 (45.6%) </td> </tr> <tr> <td> <i> *2 </i> / <i> *2 </i> </td> <td> 52 (12.4%) </td> <td> 107 (12.1%) </td> </tr> <tr> <td> <i> NAT2 </i> genotype <sup> a </sup> </td> <td> </td> <td> </td> </tr> <tr> <td> Fast acetylator </td> <td> 177 (42.2%) </td> <td> 351 (39.7%) </td> </tr> <tr> <td> Slow acetylator </td> <td> 242 (57.8%) </td> <td> 533 (60.3%) </td> </tr> </tbody> </table> </body> </html>
train
408,328
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="3"> <b> <i> SULT1A1*1 </i> /*1 genotype </b> </td> <td colspan="3"> <b> <i> SULT1A1*2 </i> allele carrier <sup> a </sup> </b> </td> </tr> </thead> <tbody> <tr> <td> Variable </td> <td> Cases ( <i> n </i> = 198) </td> <td> Controls ( <i> n </i> = 374) </td> <td> OR <sup> b </sup> (95% CI) </td> <td> Cases ( <i> n </i> = 221) </td> <td> Controls ( <i> n </i> = 510) </td> <td> OR <sup> b </sup> (95% CI) </td> </tr> <tr> <td> Never active </td> <td> 86 </td> <td> 159 </td> <td> 1 (ref) </td> <td> 88 </td> <td> 209 </td> <td> 1 (ref) </td> </tr> <tr> <td> Ever active </td> <td> 112 </td> <td> 215 </td> <td> 0.92 (0.63–1.34) </td> <td> 133 </td> <td> 301 </td> <td> 1.01 (0.73–1.42) </td> </tr> <tr> <td> Never active/passive <sup> c, d </sup> </td> <td> 20 </td> <td> 56 </td> <td> 1 (ref) </td> <td> 19 </td> <td> 57 </td> <td> 1 (ref) </td> </tr> <tr> <td> Former active </td> <td> 44 </td> <td> 94 </td> <td> 1.23 (0.64–2.36) </td> <td> 59 </td> <td> 157 </td> <td> 1.11 (0.60–2.06) </td> </tr> <tr> <td> Current active </td> <td> 68 </td> <td> 121 </td> <td> 1.44 (0.76–2.71) </td> <td> 74 </td> <td> 144 </td> <td> 1.51 (0.82–2.78) </td> </tr> <tr> <td colspan="7"> Average cigarettes per day <sup> c, e </sup> </td> </tr> <tr> <td> &gt;0–9 </td> <td> 42 </td> <td> 106 </td> <td> 1.06 (0.55–2.03) </td> <td> 52 </td> <td> 154 </td> <td> 0.99 (0.54–1.84) </td> </tr> <tr> <td> 10–19 </td> <td> 56 </td> <td> 73 </td> <td> 2.12 (1.10–4.07) </td> <td> 60 </td> <td> 99 </td> <td> 1.75 (0.94–3.25) </td> </tr> <tr> <td> 20+ </td> <td> 14 </td> <td> 34 </td> <td> 1.05 (0.45–2.46) </td> <td> 20 </td> <td> 48 </td> <td> 1.09 (0.51–2.32) </td> </tr> <tr> <td colspan="7"> Duration of smoking <sup> c, d </sup> </td> </tr> <tr> <td> 1–15 years </td> <td> 36 </td> <td> 80 </td> <td> 1.19 (0.61–2.34) </td> <td> 46 </td> <td> 145 </td> <td> 0.97 (0.52–1.82) </td> </tr> <tr> <td> 16+ years </td> <td> 76 </td> <td> 135 </td> <td> 1.44 (0.77–2.69) </td> <td> 87 </td> <td> 156 </td> <td> 1.62 (0.89–2.95) </td> </tr> <tr> <td colspan="7"> Age at first cigarette <sup> c, d </sup> </td> </tr> <tr> <td> 9–15 years </td> <td> 21 </td> <td> 47 </td> <td> 1.09 (0.51–2.35) </td> <td> 20 </td> <td> 63 </td> <td> 0.84 (0.40–1.79) </td> </tr> <tr> <td> 16–18 years </td> <td> 56 </td> <td> 109 </td> <td> 1.33 (0.70–2.52) </td> <td> 70 </td> <td> 145 </td> <td> 1.42 (0.77–2.62) </td> </tr> <tr> <td> 19+ years </td> <td> 35 </td> <td> 59 </td> <td> 1.51 (0.75–3.05) </td> <td> 43 </td> <td> 93 </td> <td> 1.42 (0.74–2.72) </td> </tr> <tr> <td colspan="7"> Pack-years <sup> c, e </sup> </td> </tr> <tr> <td> &gt;0–10 </td> <td> 59 </td> <td> 129 </td> <td> 1.22 (0.65–2.27) </td> <td> 76 </td> <td> 191 </td> <td> 1.15 (0.64–2.07) </td> </tr> <tr> <td> 11+ </td> <td> 53 </td> <td> 84 </td> <td> 1.77 (0.91–3.42) </td> <td> 56 </td> <td> 110 </td> <td> 1.43 (0.77–2.67) </td> </tr> <tr> <td colspan="7"> Passive smoking <sup> f </sup> </td> </tr> <tr> <td> No </td> <td> 20 </td> <td> 57 </td> <td> 1 (ref) </td> <td> 19 </td> <td> 57 </td> <td> 1 (ref) </td> </tr> <tr> <td> Yes </td> <td> 66 </td> <td> 102 </td> <td> 1.69 (0.89–3.21) </td> <td> 69 </td> <td> 152 </td> <td> 1.40 (0.74–2.64) </td> </tr> <tr> <td colspan="7"> Duration of passive exposure in adulthood <sup> f, g, h </sup> </td> </tr> <tr> <td> 1–13 years </td> <td> 29 </td> <td> 40 </td> <td> 1.91 (0.91–4.00) </td> <td> 33 </td> <td> 70 </td> <td> 1.47 (0.72–2.98) </td> </tr> <tr> <td> 14+ years </td> <td> 32 </td> <td> 47 </td> <td> 1.66 (0.79–3.48) </td> <td> 29 </td> <td> 61 </td> <td> 1.47 (0.70–3.10) </td> </tr> <tr> <td colspan="7"> Cumulative lifetime exposure (in hours/day-years) <sup> f, g, i </sup> </td> </tr> <tr> <td> 1–55 </td> <td> 22 </td> <td> 49 </td> <td> 1.13 (0.52–2.38) </td> <td> 37 </td> <td> 76 </td> <td> 1.76 (0.89–3.50) </td> </tr> <tr> <td> 56+ </td> <td> 43 </td> <td> 52 </td> <td> 2.12 (1.06–4.25) </td> <td> 32 </td> <td> 71 </td> <td> 1.39 (0.68–2.83) </td> </tr> </tbody> </table> </body> </html>
train
460,596
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="3"> <b> <i> SULT1A1*1 </i> / <i> *1 </i> genotype </b> </td> <td colspan="3"> <b> <i> SULT1A1*2 </i> allele carrier <sup> a </sup> </b> </td> <td colspan="3"> <b> Total </b> </td> </tr> <tr> <td> </td> <td> <b> Cases </b> </td> <td> <b> Controls </b> </td> <td> <b> OR <sup> b </sup> (95% CI) </b> </td> <td> <b> Cases </b> </td> <td> <b> Controls </b> </td> <td> <b> OR <sup> b </sup> (95% CI) </b> </td> <td> <b> Cases </b> </td> <td> <b> Controls </b> </td> <td> <b> OR <sup> b </sup> (95% CI) </b> </td> </tr> </thead> <tbody> <tr> <td colspan="10"> NAT2 fast acetylator <sup> c </sup> </td> </tr> <tr> <td> Never active/passive </td> <td> 6 </td> <td> 20 </td> <td> 1 (ref) </td> <td> 8 </td> <td> 18 </td> <td> 1 (ref) </td> <td> 14 </td> <td> 38 </td> <td> 1 (ref) </td> </tr> <tr> <td> Passive only </td> <td> 30 </td> <td> 37 </td> <td> 3.23 (1.05–9.92) </td> <td> 37 </td> <td> 59 </td> <td> 1.28 (0.50–3.31) </td> <td> 67 </td> <td> 96 </td> <td> 1.95 (0.97–3.91) </td> </tr> <tr> <td> 1–10 pack-years </td> <td> 22 </td> <td> 53 </td> <td> 1.26 (0.40–3.95) </td> <td> 30 </td> <td> 74 </td> <td> 0.76 (0.29–1.96) </td> <td> 52 </td> <td> 127 </td> <td> 0.98 (0.48–1.98) </td> </tr> <tr> <td> 11+ pack-years </td> <td> 23 </td> <td> 38 </td> <td> 2.21 (0.68–7.12) </td> <td> 20 </td> <td> 50 </td> <td> 0.75 (0.27–2.06) </td> <td> 43 </td> <td> 88 </td> <td> 1.22 (0.59–2.54) </td> </tr> <tr> <td colspan="10"> NAT2 slow acetylator </td> </tr> <tr> <td> Never active/passive </td> <td> 14 </td> <td> 33 </td> <td> 1 (ref) </td> <td> 11 </td> <td> 39 </td> <td> 1 (ref) </td> <td> 25 </td> <td> 75 </td> <td> 1 (ref) </td> </tr> <tr> <td> Passive only </td> <td> 36 </td> <td> 65 </td> <td> 1.35 (0.62–2.91) </td> <td> 32 </td> <td> 93 </td> <td> 1.18 (0.53–2.66) </td> <td> 68 </td> <td> 158 </td> <td> 1.25 (0.72–2.16) </td> </tr> <tr> <td> 1–10 pack-years </td> <td> 37 </td> <td> 76 </td> <td> 1.24 (0.57–2.69) </td> <td> 46 </td> <td> 117 </td> <td> 1.34 (0.62–2.92) </td> <td> 83 </td> <td> 193 </td> <td> 1.24 (0.72–2.12) </td> </tr> <tr> <td> 11+ pack-years </td> <td> 30 </td> <td> 46 </td> <td> 1.83 (0.79–4.26) </td> <td> 36 </td> <td> 60 </td> <td> 2.07 (0.91–4.72) </td> <td> 66 </td> <td> 106 </td> <td> 1.85 (1.04–3.30) </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Antibody </b> </td> <td> </td> <td> <b> Dilution </b> </td> <td> <b> Source </b> </td> </tr> </thead> <tbody> <tr> <td> Phospho-Akt (1/2/3) Serin 473 </td> <td> Polyclonal </td> <td> 1:200 </td> <td> Cell Signaling Technology </td> </tr> <tr> <td> Phospho-Akt (1/2/3) Serin 473 </td> <td> Polyclonal </td> <td> 1:2000 </td> <td> Santa Cruz Biotechnology </td> </tr> <tr> <td> Focal adhesion kinase (C-20) </td> <td> Polyclonal </td> <td> 1:100 </td> <td> Santa Cruz Biotechnology </td> </tr> <tr> <td> Phospho-focal adhesion kinase tyrosine 861 </td> <td> Polyclonal </td> <td> 1:50 </td> <td> Santa Cruz Biotechnology </td> </tr> <tr> <td> Phospho-Src tyrosine 215 </td> <td> Polyclonal </td> <td> 1:200 </td> <td> Sigma-Aldrich </td> </tr> <tr> <td> Phospho-Src tyrosine 416 </td> <td> Polyclonal </td> <td> 1:200 </td> <td> Cell Signaling Technology </td> </tr> <tr> <td> Phospho p44/42 Map kinase (Erk1/2) threonine 202;tyrosine 204 </td> <td> Monoclonal </td> <td> 1:100 </td> <td> Cell Signaling Technology </td> </tr> <tr> <td> Estrogen receptor </td> <td> Monoclonal </td> <td> 1:25 </td> <td> DAKO </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Expression of APC7 <sup> a </sup> </b> </td> <td colspan="2"> <b> Tissue type </b> </td> </tr> <tr> <td> </td> <td> <b> Normal tissue </b> </td> <td> <b> Tumor tissue </b> </td> </tr> </thead> <tbody> <tr> <td> Negative </td> <td> Adipocytes, brain, hepatocytes, skeletal muscle cells, spinal cord </td> <td> Lipoma, pleomorphic adenoma of salivary gland, low grade urothelial carcinoma, chondrosarcoma, adenoid cystic carcinoma, renal cell carcinoma, high grade ductal carcinoma of breast </td> </tr> <tr> <td> Positive </td> <td> Basal cells of epidermis, bronchial epithelium, ductal cells of breast, ductal cells of pancreas, ductal cells of salivary glands, endometrial glands, kidney epithelium, gastric mucosa, prostate glands and ducts, urothelial epithelium, fibroblasts, germinal center cells </td> <td> Adenocarcinoma of colon, adenocarcinoma of endometrium, adenocarcinoma of pancreas, adenocarcinoma of prostate, adenocarcinoma of stomach, ductal carcinoma of pancreas, hepatocellular carcinoma, high grade urothelial carcinoma, papillary serous carcinoma of ovary, squamous cell carcinoma of esophagus, squamous carcinoma of cervix, leiomyosarcoma of uterus, malignant lymphoma, melanoma, seminoma of testis </td> </tr> </tbody> </table> </body> </html>
train
292,340
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train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Factor </b> </td> <td> <b> <i> N </i> </b> </td> <td> <b> Mean (median) </b> </td> <td> <b> SD (SE) </b> </td> <td> <b> 95% CI </b> </td> </tr> </thead> <tbody> <tr> <td> sIL-6 </td> <td> 68 </td> <td> 2.18 (0.35) </td> <td> 3.92 (0.48) </td> <td> 1.21–3.13 </td> </tr> <tr> <td> sVEGF </td> <td> 68 </td> <td> 356.4 (285.9) </td> <td> 259.5 (31.47) </td> <td> 293.5–419.2 </td> </tr> <tr> <td> pVEGF </td> <td> 67 </td> <td> 34.81 (22.2) </td> <td> 52.56 (6.42) </td> <td> 21.99–47.63 </td> </tr> <tr> <td> D-D </td> <td> 63 </td> <td> 570.1 (419) </td> <td> 504.9 (63.61) </td> <td> 442.9–697.2 </td> </tr> <tr> <td> Platelets </td> <td> 68 </td> <td> 267.2 (266) </td> <td> 70.66 (8.57) </td> <td> 250.1–284.3 </td> </tr> <tr> <td> Fibrinogen </td> <td> 63 </td> <td> 320.9 (306) </td> <td> 73.47 (9.26) </td> <td> 302.4–339.4 </td> </tr> <tr> <td> sVEGF/pl </td> <td> 68 </td> <td> 1.37 (1.15) </td> <td> 0.92 (0.11) </td> <td> 1.15–1.60 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> SNP name </b> </td> <td> <b> dbSNP id </b> </td> <td> <b> Location </b> </td> <td> <b> Base change </b> </td> </tr> </thead> <tbody> <tr> <td> SNP 1 </td> <td> rs4252596 </td> <td> START -657 <sup> a </sup> </td> <td> C&gt;A <sup> b </sup> </td> </tr> <tr> <td> SNP 2 </td> <td> rs2952155 </td> <td> intron 1 </td> <td> C&gt;T </td> </tr> <tr> <td> SNP 3 </td> <td> rs1810132 </td> <td> intron 4 </td> <td> T&gt;C </td> </tr> <tr> <td> SNP 4 </td> <td> rs1801200 </td> <td> exon 17 (I655V) </td> <td> A&gt;G </td> </tr> <tr> <td> SNP 5 </td> <td> rs1058808 </td> <td> exon 27 (A1170P) </td> <td> G&gt;C </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> SNP </b> </td> <td> <b> Series </b> </td> <td> <b> Rare-allele frequency </b> </td> <td> <b> Common homozygote No. (%) </b> </td> <td> <b> Heterozygote No. (%) </b> </td> <td> <b> Rare homozygote No. (%) </b> </td> <td> <b> Number genotyped </b> </td> <td> <b> <i> P </i> (2df) </b> </td> </tr> </thead> <tbody> <tr> <td> SNP 1 </td> <td> Cases </td> <td> 0.13 </td> <td> 1618 (77) </td> <td> 447 (21) </td> <td> 42 (2) </td> <td> 2107 </td> <td> </td> </tr> <tr> <td> </td> <td> Controls </td> <td> 0.13 </td> <td> 1645 (75) </td> <td> 511 (23) </td> <td> 33 (2) </td> <td> 2189 </td> <td> 0.13 </td> </tr> <tr> <td> </td> <td> OR (95% CI) </td> <td> </td> <td> 1 (ref) </td> <td> 0.89 (0.77–1.03) </td> <td> 1.29 (0.82–2.05) </td> <td> </td> <td> </td> </tr> <tr> <td> SNP 2 </td> <td> Cases </td> <td> 0.25 </td> <td> 1151 (57) </td> <td> 734 (36) </td> <td> 140 (7) </td> <td> 2025 </td> <td> </td> </tr> <tr> <td> </td> <td> Controls </td> <td> 0.26 </td> <td> 1219 (55) </td> <td> 839 (38) </td> <td> 147 (7) </td> <td> 2205 </td> <td> 0.48 </td> </tr> <tr> <td> </td> <td> OR (95% CI) </td> <td> </td> <td> 1 (ref) </td> <td> 0.93 (0.82–1.05) </td> <td> 1.01 (0.79–1.29) </td> <td> </td> <td> </td> </tr> <tr> <td> SNP 3 </td> <td> Cases </td> <td> 0.32 </td> <td> 962 (47) </td> <td> 855 (42) </td> <td> 219 (11) </td> <td> 2036 </td> <td> </td> </tr> <tr> <td> </td> <td> Controls </td> <td> 0.32 </td> <td> 1022 (46) </td> <td> 956 (43) </td> <td> 230 (11) </td> <td> 2208 </td> <td> 0.69 </td> </tr> <tr> <td> </td> <td> OR (95% CI) </td> <td> </td> <td> 1 (ref) </td> <td> 0.95 (0.84–1.08) </td> <td> 1.01 (0.82–1.24) </td> <td> </td> <td> </td> </tr> <tr> <td> SNP 4 </td> <td> Cases </td> <td> 0.25 </td> <td> 1128 (57) </td> <td> 748 (37) </td> <td> 113 (6) </td> <td> 1989 </td> <td> </td> </tr> <tr> <td> </td> <td> Controls </td> <td> 0.25 </td> <td> 1230 (57) </td> <td> 791 (37) </td> <td> 134 (6) </td> <td> 2155 </td> <td> 0.69 </td> </tr> <tr> <td> </td> <td> OR (95% CI) </td> <td> </td> <td> 1 (ref) </td> <td> 1.03 (0.91–1.17) </td> <td> 0.92 (0.71–1.20) </td> <td> </td> <td> </td> </tr> <tr> <td> SNP 5 </td> <td> Cases </td> <td> 0.33 </td> <td> 911 (45) </td> <td> 870 (43) </td> <td> 233 (12) </td> <td> 2014 </td> <td> </td> </tr> <tr> <td> </td> <td> Controls </td> <td> 0.33 </td> <td> 960 (44) </td> <td> 983 (45) </td> <td> 238 (11) </td> <td> 2181 </td> <td> 0.45 </td> </tr> <tr> <td> </td> <td> OR (95% CI) </td> <td> </td> <td> 1 (ref) </td> <td> 0.93 (0.82–1.06) </td> <td> 1.03 (0.84–1.26) </td> <td> </td> <td> </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Haplotype </b> </td> <td> <b> Allele <sup> a </sup> </b> </td> <td> <b> Frequency (cases) </b> </td> <td> <b> Frequency (controls) </b> </td> <td> <b> <i> P </i> <sup> b </sup> </b> </td> </tr> </thead> <tbody> <tr> <td> (1) </td> <td> cctIA </td> <td> 0.35 </td> <td> 0.36 </td> <td> 0.80 </td> </tr> <tr> <td> (2) </td> <td> ctcIP </td> <td> 0.19 </td> <td> 0.18 </td> <td> 0.88 </td> </tr> <tr> <td> (3) </td> <td> cctVA </td> <td> 0.18 </td> <td> 0.16 </td> <td> 0.15 </td> </tr> <tr> <td> (4) </td> <td> actIA </td> <td> 0.13 </td> <td> 0.13 </td> <td> 0.49 </td> </tr> <tr> <td> (5) </td> <td> ctcVP </td> <td> 0.06 </td> <td> 0.08 </td> <td> 0.07 </td> </tr> <tr> <td> (6) </td> <td> cccIP </td> <td> 0.07 </td> <td> 0.07 </td> <td> 0.50 </td> </tr> <tr> <td> (7) </td> <td> cctIP </td> <td> 0.02 </td> <td> 0.01 </td> <td> 0.93 </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Primer </b> </td> <td colspan="3"> <b> Forward </b> </td> <td colspan="3"> <b> Reverse </b> </td> <td> <b> Product size (bp) </b> </td> <td> <b> GI number </b> </td> </tr> <tr> <td> </td> <td> <b> Sequence 5'–3' </b> </td> <td> <b> Size (bp) </b> </td> <td> </td> <td> <b> Sequence 5'–3' </b> </td> <td> <b> Size (bp) </b> </td> <td> </td> <td> </td> <td> </td> </tr> </thead> <tbody> <tr> <td> CLDN1 </td> <td> ttcgtacctggcattgactgg </td> <td> 378–399 </td> <td> 22 </td> <td> ttc gta cct ggc att gac tgg </td> <td> 470–490 </td> <td> 21 </td> <td> 112 </td> <td> 4559277 </td> </tr> <tr> <td> CLDN3 </td> <td> ctgctctgctgctcgtgtcc </td> <td> 732–751 </td> <td> 20 </td> <td> ttagacgtagtccttgcggtcgtag </td> <td> 836–860 </td> <td> 25 </td> <td> 128 </td> <td> 21536298 </td> </tr> <tr> <td> CLDN4 </td> <td> ggctgctttgctgcaactgtc </td> <td> 741–761 </td> <td> 21 </td> <td> gagccgtggcaccttacacg </td> <td> 829–848 </td> <td> 20 </td> <td> 107 </td> <td> 14790131 </td> </tr> <tr> <td> GAPDH </td> <td> gaagatggtgatgggatttc </td> <td> 81–98 </td> <td> 20 </td> <td> gaaggtgaaggtcggagt </td> <td> 287–306 </td> <td> 18 </td> <td> 225 </td> <td> 7669491 </td> </tr> </tbody> </table> </body> </html>
train
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train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Prognostic factor </b> </td> <td> <b> <i> P </i> </b> </td> <td> <b> RR </b> </td> <td> <b> 95% CI </b> </td> </tr> </thead> <tbody> <tr> <td> Age </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> Menopausal status </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> pT stage </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> Grade </td> <td> 0.0003 </td> <td> 4.26 </td> <td> 1.96–9.29 </td> </tr> <tr> <td> Steroid hormone receptor status </td> <td> 0.012 </td> <td> 0.32 </td> <td> 0.13–0.78 </td> </tr> <tr> <td> HER2_SCO </td> <td> 0.047 </td> <td> 1.60 </td> <td> 1.01–2.53 </td> </tr> <tr> <td> HER2_AMP </td> <td> 0.004 </td> <td> 3.78 </td> <td> 1.54–9.26 </td> </tr> <tr> <td> HER2_ALG </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> HER2_COM </td> <td> 0.004 </td> <td> 4.18 </td> <td> 1.60–10.90 </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Prognostic factor </b> </td> <td> <b> <i> P </i> </b> </td> <td> <b> RR </b> </td> <td> <b> 95% CI </b> </td> </tr> </thead> <tbody> <tr> <td> Age </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> Menopausal status </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> pT stage </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> Grade </td> <td> 0.0007 </td> <td> 3.89 </td> <td> 1.77–8.55 </td> </tr> <tr> <td> Steroid hormone receptor status </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> HER2_SCO </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> HER2_AMP </td> <td> 0.016 </td> <td> 3.08 </td> <td> 1.24–7.66 </td> </tr> <tr> <td> HER2_ALG </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> <tr> <td> HER2_COM </td> <td> n.s. </td> <td> - </td> <td> - </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="3"> <b> Polysomy 17 </b> </td> <td colspan="2"> <b> Non-polysomy 17 </b> </td> </tr> </thead> <tbody> <tr> <td> IHC score </td> <td> FISH normal </td> <td> FISH amplified </td> <td> Polysomy 17 (%) </td> <td> FISH normal </td> <td> FISH amplified </td> </tr> <tr> <td> 0 </td> <td> 0/8 </td> <td> 0/0 </td> <td> 0 </td> <td> 8/8 </td> <td> 0/0 </td> </tr> <tr> <td> 1+ </td> <td> 0/20 </td> <td> 0/0 </td> <td> 0 </td> <td> 20/20 </td> <td> 0/0 </td> </tr> <tr> <td> 2+ </td> <td> 13/66 </td> <td> 0/12 </td> <td> 17 </td> <td> 53/66 </td> <td> 12/12 </td> </tr> <tr> <td> 3+ </td> <td> 1/1 </td> <td> 8/68 </td> <td> 15 </td> <td> 0/1 </td> <td> 60/68 </td> </tr> <tr> <td> Total </td> <td> 14/95 (15%) </td> <td> 8/80 (10%) </td> <td> 13 </td> <td> 81/95 (85%) </td> <td> 72/80 (90%) </td> </tr> </tbody> </table> </body> </html>
train
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train
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train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> ACR criterion </b> </td> <td colspan="2"> <b> Patients </b> </td> </tr> <tr> <td> </td> <td> <b> No. </b> </td> <td> <b> % </b> </td> </tr> </thead> <tbody> <tr> <td> Malar rash </td> <td> 79 </td> <td> 55 </td> </tr> <tr> <td> Discoid rash </td> <td> 55 </td> <td> 38 </td> </tr> <tr> <td> Photosensitivity </td> <td> 102 </td> <td> 71 </td> </tr> <tr> <td> Oral ulcers </td> <td> 38 </td> <td> 27 </td> </tr> <tr> <td> Arthritis </td> <td> 118 </td> <td> 83 </td> </tr> <tr> <td> Serositis </td> <td> 76 </td> <td> 53 </td> </tr> <tr> <td> Renal disorder </td> <td> 38 </td> <td> 27 </td> </tr> <tr> <td> Neurologic disorder </td> <td> 12 </td> <td> 8 </td> </tr> <tr> <td> Hematologic disorder </td> <td> 73 </td> <td> 51 </td> </tr> <tr> <td> Immunologic disorder </td> <td> 103 </td> <td> 76 </td> </tr> <tr> <td> Antinuclear antibody </td> <td> 143 </td> <td> 100 </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> <i> p53 </i> mutation </b> </td> <td> <b> Origin </b> </td> <td> <b> Reference </b> </td> </tr> </thead> <tbody> <tr> <td> Codon 138 GCC&gt;GTC (Ala&gt;Val) </td> <td> Microdissected synovial tissue </td> <td> [9] </td> </tr> <tr> <td> Deletion codon 143 – codon 220 </td> <td> Microdissected synovial tissue </td> <td> [9] </td> </tr> <tr> <td> Codon 144 CAG&gt;TAG (Gly&gt;stop) </td> <td> Microdissected synovial tissue </td> <td> [9] </td> </tr> <tr> <td> Codon 176 TGC&gt;CGC (Cys&gt;Arg) </td> <td> Microdissected synovial tissue </td> <td> [9] </td> </tr> <tr> <td> Codon 213 CGA&gt;TGA (Arg&gt;stop) </td> <td> Microdissected synovial tissue </td> <td> [9] </td> </tr> <tr> <td> Codon 245 GGC&gt;GAC (Gly&gt;Asp) </td> <td> Cultured FLS </td> <td> [23] </td> </tr> <tr> <td> Codon 249 AGG&gt;GGG (Arg&gt;Gly) </td> <td> Cultured FLS </td> <td> Present study </td> </tr> <tr> <td> Codon 300 CCC&gt;TCC(Pro&gt;Ser) </td> <td> Microdissected synovial tissue </td> <td> [9] </td> </tr> <tr> <td> Codon 307 GCA&gt;GCT (Ala&gt;Ala) </td> <td> Cultured FLS </td> <td> Present study </td> </tr> <tr> <td> Codon 321 AAA&gt;GAA (Lys&gt;Glu) </td> <td> Cultured FLS </td> <td> Present study </td> </tr> <tr> <td> Codon 337 CGC&gt;AGC (Arg&gt;Ser) </td> <td> Microdissected synovial tissue </td> <td> [9] </td> </tr> </tbody> </table> </body> </html>
train
277,212
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Patients </b> </td> <td> <b> <i> n </i> </b> </td> <td> <b> Age <sup> a </sup> range (median; years) </b> </td> <td> <b> Sex (male/female) </b> </td> <td> <b> Graft manipulation </b> </td> </tr> </thead> <tbody> <tr> <td> RA cohort 1 </td> <td> 9 </td> <td> 32–61 (42) </td> <td> 2/7 </td> <td> Unmanipulated </td> </tr> <tr> <td> RA cohort 2 </td> <td> 16 </td> <td> 43–55 (47) </td> <td> 4/12 </td> <td> CD34 selection </td> </tr> <tr> <td> RA cohort 3 </td> <td> 6 </td> <td> 24–61 (39) </td> <td> 3/3 </td> <td> CD34 selection, T-cell depletion </td> </tr> <tr> <td> Solid tumours </td> <td> 7 </td> <td> 39–64 (44) </td> <td> 2/5 </td> <td> Unmanipulated </td> </tr> <tr> <td> Lymphoma/sarcoma </td> <td> 7 </td> <td> 22–64 (46) </td> <td> 5/2 </td> <td> Unmanipulated </td> </tr> <tr> <td> Systemic vasculitis (depleting antibody therapy) </td> <td> 3 </td> <td> 43–61 (52) </td> <td> 2/1 </td> <td> Not applicable </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Systemic onset JRA ( <i> n </i> = 20) </b> </td> <td> <b> Polyarticular JRA ( <i> n </i> = 16) or pauciarticular JRA ( <i> n </i> = 4) </b> </td> </tr> </thead> <tbody> <tr> <td> Male/female </td> <td> 9/11 </td> <td> 14/6 </td> </tr> <tr> <td> Mean age, years (range) </td> <td> 11.5 (2–23) </td> <td> 12.8 (3–22) </td> </tr> <tr> <td> Mean disease duration, years (range) </td> <td> 4.1 (0.2–16) </td> <td> 5.8 (0.9–15) </td> </tr> <tr> <td> No. with active arthritis (%) </td> <td> 17 (85) </td> <td> 17 (85) </td> </tr> <tr> <td> No. with active systemic disease (%) </td> <td> 8 (40) </td> <td> - </td> </tr> <tr> <td> Mean ESR, mm/h (range) </td> <td> 30 (5–85) </td> <td> 21 (5–57) </td> </tr> <tr> <td> No. (%) receiving </td> <td> </td> <td> </td> </tr> <tr> <td> Prednisone </td> <td> 6 (30) </td> <td> 3 (15) </td> </tr> <tr> <td> Methotrexate </td> <td> 12 (60) </td> <td> 10 (50) </td> </tr> <tr> <td> TNF-blocking agent </td> <td> 3 (15) </td> <td> 5 (25) </td> </tr> <tr> <td> Intra-articular steroids </td> <td> 1 (5) </td> <td> 4 (20) </td> </tr> <tr> <td> NSAID </td> <td> 17 (85) </td> <td> 18 (90) </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="2"> <b> MMP-9 (ng/ml) <sup> a </sup> </b> </td> </tr> <tr> <td> <b> Variable </b> </td> <td> <b> Variable present (%) <sup> b </sup> </b> </td> <td> <b> Variable absent </b> </td> </tr> </thead> <tbody> <tr> <td> Modified Rodnan score &gt;20 </td> <td> 388 ± 29 (51)* </td> <td> 248 ± 38* </td> </tr> <tr> <td> Esophageal involvement <sup> c </sup> </td> <td> 342 ± 33 (63) </td> <td> 304 ± 41 </td> </tr> <tr> <td> Interstitial lung disease <sup> d </sup> </td> <td> 321 ± 32 (60) </td> <td> 335 ± 41 </td> </tr> <tr> <td> Decrease of DLCO (&lt;70%) <sup> e </sup> </td> <td> 350 ± 42 (43) </td> <td> 314 ± 34 </td> </tr> <tr> <td> Digital ulcer </td> <td> 364 ± 32 (43) </td> <td> 260 ± 35 </td> </tr> <tr> <td> Arthritis </td> <td> 333 ± 58 (14) </td> <td> 333 ± 28 </td> </tr> <tr> <td> Sicca syndrome </td> <td> 358 ± 40 (31) </td> <td> 320 ± 31 </td> </tr> <tr> <td> Antibodies to Scl-70 <sup> f </sup> </td> <td> 348 ± 36 (37) </td> <td> 323 ± 45 </td> </tr> <tr> <td> Antibodies to centromere-B <sup> f </sup> </td> <td> 288 ± 34 (37) </td> <td> 370 ± 39 </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Sera ( <i> n </i> ) </b> </td> <td> <b> Number (%) of anti-SMP positive sera </b> </td> <td> <b> Mean value (U/ml) </b> </td> <td> <b> Top value (U/ml) </b> </td> </tr> </thead> <tbody> <tr> <td> SLE (176) </td> <td> 28 (15.9) </td> <td> 43.0 </td> <td> 1190.0 </td> </tr> <tr> <td> Rheumatic diseases (181) </td> <td> 1 (0.6) </td> <td> 2.2 </td> <td> 24.6 </td> </tr> <tr> <td> RA (86) </td> <td> 1 (1.2) </td> <td> 1.6 </td> <td> 24.6 </td> </tr> <tr> <td> pSS (24) </td> <td> 0 </td> <td> 1.9 </td> <td> 3.9 </td> </tr> <tr> <td> MCTD (26) </td> <td> 0 </td> <td> 3.1 </td> <td> 12.8 </td> </tr> <tr> <td> SSc (26) </td> <td> 0 </td> <td> 2.4 </td> <td> 4.3 </td> </tr> <tr> <td> PM/DM (13) </td> <td> 0 </td> <td> 2.8 </td> <td> 9.6 </td> </tr> <tr> <td> Overlap syndromes (8) </td> <td> 0 </td> <td> 2.1 </td> <td> 3.6 </td> </tr> <tr> <td> Infectious diseases (77) </td> <td> 0 </td> <td> 0.67 </td> <td> 3.3 </td> </tr> <tr> <td> HCV (30) </td> <td> 0 </td> <td> 0.42 </td> <td> 1.1 </td> </tr> <tr> <td> CMV (22) </td> <td> 0 </td> <td> 0.8 </td> <td> 3.2 </td> </tr> <tr> <td> EBV (25) </td> <td> 0 </td> <td> 0.78 </td> <td> 3.3 </td> </tr> <tr> <td> Healthy individuals (192) </td> <td> 0 </td> <td> 2.21 </td> <td> 11.5 </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Sample ID </b> </td> <td> <b> U/ml </b> </td> <td> <b> Sample ID </b> </td> <td> <b> U/ml </b> </td> <td> <b> Diagnosis </b> </td> </tr> </thead> <tbody> <tr> <td> ANA 1 </td> <td> 10.3 </td> <td> SLR Research A </td> <td> 2.5 </td> <td> CREST </td> </tr> <tr> <td> ANA 2 </td> <td> 1.4 </td> <td> SLR Research B </td> <td> 2.9 </td> <td> Scl </td> </tr> <tr> <td> ANA 3 </td> <td> 1.9 </td> <td> SLR Research D </td> <td> 2.8 </td> <td> MCTD </td> </tr> <tr> <td> ANA 4 </td> <td> 2.5 </td> <td> SLR Research E </td> <td> 3.1 </td> <td> SS, SLE </td> </tr> <tr> <td> ANA 5 </td> <td> 910.0 </td> <td> SLR Research F </td> <td> 1.5 </td> <td> PM </td> </tr> <tr> <td> ANA 6 </td> <td> 3.1 </td> <td> SLR Research G </td> <td> 4.5 </td> <td> SS </td> </tr> <tr> <td> ANA 7 </td> <td> 0.0 </td> <td> SLR Research I </td> <td> 1420.0 </td> <td> SLE </td> </tr> <tr> <td> ANA 8 </td> <td> 0.1 </td> <td> SLR Research J </td> <td> 13.9 </td> <td> SLE </td> </tr> <tr> <td> ANA 9 </td> <td> 1.7 </td> <td> SLR Research K </td> <td> 0.0 </td> <td> HD </td> </tr> <tr> <td> ANA 10 </td> <td> 0.5 </td> <td> SLR Research L </td> <td> 0.2 </td> <td> HD </td> </tr> </tbody> </table> </body> </html>
train
443,060
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Accession no. </b> </td> <td> <b> Gene </b> </td> <td> <b> Delta </b> </td> <td> <b> Rat CL </b> </td> <td> <b> Rat QTLs </b> </td> <td> <b> Human CL </b> </td> <td> <b> Human QTLs </b> </td> </tr> </thead> <tbody> <tr> <td> NM_178144 </td> <td> AMIGO3 </td> <td> Nd/Nd/5.9 </td> <td> 8q32 </td> <td> Cia6 </td> <td> 3p21.31 </td> <td> Asthma </td> </tr> <tr> <td> NM_130411 </td> <td> CORO1A </td> <td> 3.1/2.7/6.6 </td> <td> 1q36 </td> <td> Pia11 </td> <td> 16p12.1 </td> <td> Blau syndrome, asthma </td> </tr> <tr> <td> NM_024381 </td> <td> GYK </td> <td> 6.7/Nd/Nd </td> <td> Xq22 </td> <td> Cia19 </td> <td> Xp21.3 </td> <td> Allergic rhinitis </td> </tr> <tr> <td> NM_031670 </td> <td> KDAP </td> <td> 18.8/6.6/48.2 </td> <td> 1q22 </td> <td> _ </td> <td> 19q13.3 </td> <td> Asthma, SLE, MS, SD </td> </tr> <tr> <td> NM_569105 </td> <td> LCP2 </td> <td> 2.6/3.3/6.2 </td> <td> 10q12 </td> <td> Cia16, Pia15 </td> <td> 5q33.1 </td> <td> RA, PDB, asthma, IBD, psoriasis, ATD </td> </tr> <tr> <td> NM_021586 </td> <td> LTBP2 </td> <td> Nd/Nd/6.5 </td> <td> 6q31 </td> <td> Pia3, Pia24 </td> <td> 14q24 </td> <td> SLE, MODY3 </td> </tr> <tr> <td> NM_198746 </td> <td> Ly-49.9 </td> <td> Nd/2.0/5.6 </td> <td> 4q42 </td> <td> Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4 </td> <td> 12p13-p12 </td> <td> RA, allergic rhinitis, hypophosphataemic rickets </td> </tr> <tr> <td> NM_022667 </td> <td> MATR1 </td> <td> 1.7/1.9/5.7 </td> <td> 8q32 </td> <td> Cia6 </td> <td> 3q21 </td> <td> Atopic dermatitis, asthma, psoriasis </td> </tr> <tr> <td> NM_133306 </td> <td> OLR1 </td> <td> 8.3/2.8/3.7 </td> <td> 4q42 </td> <td> Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4 </td> <td> 12p13.2-p12.3 </td> <td> RA, hypophosphataemic rickets, allergic rhinitis </td> </tr> <tr> <td> NM_053687 </td> <td> SLFN4 </td> <td> 5.8/4.6/4.8 </td> <td> 10q26 </td> <td> Cia16, Cia21, Cia22, Cia23, Oia4, Ciaa2 </td> <td> 17q11.2-q21.1 </td> <td> SLE, MS </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="7"> <b> Disease-modifying antirheumatic drug </b> </td> </tr> <tr> <td> </td> <td> <b> None </b> </td> <td> <b> Methotrexate </b> </td> <td> <b> Leflunomide </b> </td> <td> <b> Sulfasalazopyrine </b> </td> <td> <b> Gold </b> </td> <td> <b> Chloroquine </b> </td> <td> <b> Others </b> </td> </tr> </thead> <tbody> <tr> <td> Number </td> <td> 22 </td> <td> 42 </td> <td> 10 </td> <td> 10 </td> <td> 6 </td> <td> 4 </td> <td> 6 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td> <b> Mean </b> </td> <td> <b> Standard deviation </b> </td> <td> <b> <i> n </i> </b> </td> <td> <b> Coeffficient </b> </td> <td> <b> Probability &gt; | <i> r </i> | </b> </td> </tr> </thead> <tbody> <tr> <td> Variable 1 </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Cathepsin K </td> <td> 304.66 </td> <td> 677.607 </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Variable 2 </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Age (years) </td> <td> 62.89 </td> <td> 11.1581 </td> <td> 100 </td> <td> 0.0543 </td> <td> 0.5915 </td> </tr> <tr> <td> Rheumatoid factor (U/l) </td> <td> 298.818 </td> <td> 1136.49 </td> <td> 100 </td> <td> 0.4761 </td> <td> &lt; 0.0001 </td> </tr> <tr> <td> Morning stiffness (min) </td> <td> 32 </td> <td> 38.7233 </td> <td> 100 </td> <td> 0.1320 </td> <td> 0.1905 </td> </tr> <tr> <td> Erythrocyte sedimentation rate (mm/hour) </td> <td> 30.27 </td> <td> 20.8404 </td> <td> 100 </td> <td> 0.2200 </td> <td> 0.0279 </td> </tr> <tr> <td> C-reactive protein (mg/l) </td> <td> 24.96 </td> <td> 23.5032 </td> <td> 100 </td> <td> 0.1121 </td> <td> 0.2670 </td> </tr> <tr> <td> Ritchie score </td> <td> 11.31 </td> <td> 10.3394 </td> <td> 100 </td> <td> 0.1353 </td> <td> 0.1797 </td> </tr> <tr> <td> Proximal interphalangeal score </td> <td> 1.51 </td> <td> 2.69865 </td> <td> 100 </td> <td> 0.2560 </td> <td> 0.0101 </td> </tr> <tr> <td> Disease activity score </td> <td> 3.33283 </td> <td> 1.43345 </td> <td> 100 </td> <td> 0.2093 </td> <td> 0.0376 </td> </tr> <tr> <td> Larsen score </td> <td> 54.77 </td> <td> 49.3335 </td> <td> 100 </td> <td> 0.2856 </td> <td> 0.0040 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td colspan="2"> <b> Larsen group </b> </td> <td colspan="3"> <b> Larsen score </b> </td> <td colspan="3"> <b> Cathepsin K </b> </td> <td> <b> Kruskal–Wallis test </b> </td> </tr> <tr> <td> </td> <td> <b> <i> n </i> </b> </td> <td> <b> Minimum </b> </td> <td> <b> Median </b> </td> <td> <b> Maximum </b> </td> <td> <b> Minimum </b> </td> <td> <b> Median </b> </td> <td> <b> Maximum </b> </td> <td> </td> </tr> </thead> <tbody> <tr> <td> &lt; 18 </td> <td> 32 </td> <td> 0.0 </td> <td> 7.5 </td> <td> 17.0 </td> <td> 0.0 </td> <td> 26.5 </td> <td> 3352.0 </td> <td> </td> </tr> <tr> <td> ≥ 19 and &lt; 74 </td> <td> 34 </td> <td> 18.0 </td> <td> 38.0 </td> <td> 67.0 </td> <td> 0.0 </td> <td> 70.9 </td> <td> 1721.6 </td> <td> </td> </tr> <tr> <td> ≥ 75 </td> <td> 34 </td> <td> 75.0 </td> <td> 105.5 </td> <td> 164.0 </td> <td> 0.0 </td> <td> 88.8 </td> <td> 3453.2 </td> <td> </td> </tr> <tr> <td> Total </td> <td> 100 </td> <td> 0.0 </td> <td> 39.0 </td> <td> 164.0 </td> <td> 0.0 </td> <td> 54.8 </td> <td> 3453.2 </td> <td> <i> P </i> = 0.035 </td> </tr> </tbody> </table> </body> </html>
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train
82,185
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train
333,246
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Gene </b> </td> <td> <b> Forward primer </b> </td> <td> <b> Reverse primer </b> </td> <td> <b> Product size (base pairs) </b> </td> </tr> </thead> <tbody> <tr> <td> IFN-γ </td> <td> 5'-gcg tca ttg aat cac acc tg-3' </td> <td> 5'-gac ctg tgg gtt gtt gac ct-3' </td> <td> 104 </td> </tr> <tr> <td> IL-1β </td> <td> 5'-cag gca ggc agt atc act ca-3' </td> <td> 5'-atg agt cac aga gga tgg gc-3' </td> <td> 140 </td> </tr> <tr> <td> IL-4 </td> <td> 5'-agc tgc aga gac tct ttc gg-3' </td> <td> 5'-tgc tct tta ggc ttt cca gg-3' </td> <td> 111 </td> </tr> <tr> <td> IL-6 </td> <td> 5'-ccg gag agg aga ctt cac ag-3' </td> <td> 5'-cag aat tgc cat tgc aca ac-3' </td> <td> 134 </td> </tr> <tr> <td> IL-17 </td> <td> 5'-cct aag aaa ccc cca cgt tt-3' </td> <td> 5'-ttc ttt tca ttg tgg agg gc-3' </td> <td> 129 </td> </tr> <tr> <td> TNF-α </td> <td> 5'-acg gca tgg atc tca aag ac-3' </td> <td> 5'-gtg ggt gag gag cac gta gt-3' </td> <td> 116 </td> </tr> <tr> <td> MMP-2 </td> <td> 5'-agc gtg aag ttt gga agc at-3' </td> <td> 5'-cac atc ctt cac ctg gtg tg-3' </td> <td> 105 </td> </tr> <tr> <td> MMP-3 </td> <td> 5'-tgg aga tgc tca ctt tga cg-3' </td> <td> 5'-gcc ttg gct gag tgg tag ag-3' </td> <td> 120 </td> </tr> <tr> <td> MMP-9 </td> <td> 5'-cat tcg cgt gga taa gga gt-3' </td> <td> 5'-att ttg gaa act cac acg cc-3' </td> <td> 118 </td> </tr> <tr> <td> MMP-12 </td> <td> 5'-ttt gga gct cac gga gac tt-3' </td> <td> 5'-cac gtt tct gcc tca tca aa-3' </td> <td> 116 </td> </tr> <tr> <td> MMP-13 </td> <td> 5'-agt tga cag gct ccg aga aa-3' </td> <td> 5'-ggc act cca cat ctt ggt tt-3' </td> <td> 105 </td> </tr> <tr> <td> TIMP-1 </td> <td> 5'-ggt gtt tcc ctg ttt atc-3' </td> <td> 5'-tag ttc ttt att tca cca tct-3' </td> <td> 254 </td> </tr> <tr> <td> TIMP-3 </td> <td> 5'-ttg ggt acc ctg gct atc ag-3' </td> <td> 5'-agg tct ggg ttc agg gat ct-3' </td> <td> 132 </td> </tr> <tr> <td> Cathepsin B </td> <td> 5'-gga gat act ccc agg tgc aa-3' </td> <td> 5'-ctg cca tga tct cct tca ca-3' </td> <td> 121 </td> </tr> <tr> <td> Cathepsin H </td> <td> 5'-gg cag agc ctc aga att gc-3' </td> <td> 5'-act ggc gaa aca aca ttt gc-3' </td> <td> 109 </td> </tr> <tr> <td> Cathepsin K </td> <td> 5'-ggg cca gga tga aag ttg ta-3' </td> <td> 5'-cac tgc tct ctt cag ggc tt-3' </td> <td> 106 </td> </tr> <tr> <td> Cathepsin L </td> <td> 5'-atc ccc aag tct gtg gac tg-3' </td> <td> 5'-tca gtg aga tca gtt tgc cg-3' </td> <td> 145 </td> </tr> <tr> <td> Cathepsin S </td> <td> 5'-aga gaa ggg ctg cgt cac t-3' </td> <td> 5'-gat atc agc ttc ccc gtt ttc ag-3' </td> <td> 117 </td> </tr> <tr> <td> Cystatin B </td> <td> 5'-tgc tga caa ggt cag acc ac-3' </td> <td> 5'-gca acc acg tcc tac att ca-3' </td> <td> 133 </td> </tr> <tr> <td> β-actin </td> <td> 5'-cca cag ctg aga ggg aaa tc-3' </td> <td> 5'-tct cca ggg agg aag agg at-3' </td> <td> 108 </td> </tr> </tbody> </table> </body> </html>
train
398,060
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Cells </b> </td> <td> <b> hTNFtg </b> </td> <td> <b> <i> JNK1 </i> <sup> -/- </sup> hTNFtg </b> </td> </tr> </thead> <tbody> <tr> <td> Macrophages </td> <td> 49.5 ± 7.8 </td> <td> 50.5 ± 5.3 </td> </tr> <tr> <td> Granulocytes </td> <td> 17.7 ± 1.5 </td> <td> 15.5 ± 2.5 </td> </tr> <tr> <td> T lymphocytes </td> <td> 5.0 ± 1.0 </td> <td> 6.7 ± 0.6 </td> </tr> <tr> <td> B lymphocytes </td> <td> 6.3 ± 2.1 </td> <td> 5.0 ± 1.8 </td> </tr> </tbody> </table> </body> </html>
train
503,577
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Site/parameter </b> </td> <td> <b> Girl </b> </td> <td> <b> Boy </b> </td> </tr> </thead> <tbody> <tr> <td> At the scene </td> <td> </td> <td> </td> </tr> <tr> <td> Time to bystander CPR (min) </td> <td> &gt; 10 </td> <td> &gt; 10 </td> </tr> <tr> <td> Pulseless bradycardia under CPR </td> <td> Yes </td> <td> Yes </td> </tr> <tr> <td> On admission </td> <td> </td> <td> </td> </tr> <tr> <td> Pupils dilated, nonreactive to light </td> <td> Yes </td> <td> Yes </td> </tr> <tr> <td> Corneal reflex </td> <td> Negative </td> <td> Negative </td> </tr> <tr> <td> Temperature on admission (°C) </td> <td> &lt;28 </td> <td> &lt;27 </td> </tr> <tr> <td> pH on admission </td> <td> 6.63 </td> <td> 7.00 </td> </tr> <tr> <td> Arterial CO <sub> 2 </sub> tension (torr) </td> <td> 38 </td> <td> 36 </td> </tr> <tr> <td> BE on admission (mmol/l) </td> <td> -27 </td> <td> -17 </td> </tr> <tr> <td> Oxygenation index (torr) </td> <td> 75 </td> <td> 65 </td> </tr> <tr> <td> CPR time (min) </td> <td> 180 </td> <td> 120 </td> </tr> </tbody> </table> </body> </html>
train
2,501
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> <i> Initials XX </i> </b> </td> <td> <b> <i> Study number Axxxx </i> </b> </td> <td> <b> <i> Date of arrival xx/xx/xx </i> </b> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> <b> Time </b> </td> <td> <b> Heart rate &gt;80 </b> </td> <td> <b> Clear lungs </b> </td> <td> <b> Pupil size </b> </td> <td> <b> Dry axilla </b> </td> <td> <b> Syst. BP &gt;80 mmHg </b> </td> <td> <b> Bowel sounds (A/D/N/I) </b> </td> <td> <b> Confused </b> </td> <td> <b> Fever (&gt;37.5°C) </b> </td> <td> <b> Atropine infusion </b> </td> <td> <b> Bolus given? </b> </td> </tr> </thead> <tbody> <tr> <td> 22.30 </td> <td> <b> <i> 52 </i> </b> </td> <td> <b> <i> Creps+ </i> </b> </td> <td> <b> <i> Pinpoint </i> </b> </td> <td> <b> <i> No </i> </b> </td> <td> 90/60 </td> <td> I </td> <td> No </td> <td> No </td> <td> </td> <td> 2.4 mg </td> </tr> <tr> <td> 22.35 </td> <td> <b> <i> 60 </i> </b> </td> <td> <b> <i> Creps+ </i> </b> </td> <td> <b> <i> Pinpoint </i> </b> </td> <td> <b> <i> No </i> </b> </td> <td> 90/60 </td> <td> I </td> <td> No </td> <td> No </td> <td> </td> <td> 4.8 mg </td> </tr> <tr> <td> 22.40 </td> <td> 82 </td> <td> <b> +/- </b> </td> <td> <b> <i> Pinpoint </i> </b> </td> <td> Yes </td> <td> 110/60 </td> <td> N </td> <td> No </td> <td> No </td> <td> </td> <td> 4 mg </td> </tr> <tr> <td> 22.50 </td> <td> 100 </td> <td> <b> <i> Wheeze </i> </b> </td> <td> 2 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> </td> <td> 2 mg </td> </tr> <tr> <td> 23.00 </td> <td> 105 </td> <td> Clear </td> <td> 3 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> 2 mg/h </td> <td> Infusion </td> </tr> <tr> <td> 23.15 </td> <td> 105 </td> <td> Clear </td> <td> 3–4 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> 2 mg/h </td> <td> Infusion </td> </tr> <tr> <td> 23.32 </td> <td> 102 </td> <td> Clear </td> <td> 3–4 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> 2 mg/h </td> <td> Infusion </td> </tr> <tr> <td> 00.30 </td> <td> 98 </td> <td> Clear </td> <td> 3–4 mm </td> <td> Yes </td> <td> 110/60 </td> <td> D </td> <td> No </td> <td> No </td> <td> 2 mg/h </td> <td> Infusion </td> </tr> <tr> <td> 01.30 </td> <td> 85 </td> <td> Clear </td> <td> 3–4 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> 2 mg/h </td> <td> Infusion </td> </tr> <tr> <td> 02.30 </td> <td> <b> <i> 72 </i> </b> </td> <td> <b> <i> Wheeze </i> </b> </td> <td> 3–4 mm </td> <td> Yes </td> <td> - </td> <td> N/D </td> <td> No </td> <td> No </td> <td> </td> <td> 2 mg </td> </tr> <tr> <td> 02.35 </td> <td> 96 </td> <td> Clear </td> <td> 3–4 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> 2.4 mg/h </td> <td> Infusion </td> </tr> <tr> <td> 02.45 </td> <td> 98 </td> <td> Clear </td> <td> 3–4 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> 2.4 mg/h </td> <td> Infusion </td> </tr> <tr> <td> 04.00 </td> <td> 102 </td> <td> Clear </td> <td> 3–4 mm </td> <td> Yes </td> <td> - </td> <td> D </td> <td> No </td> <td> No </td> <td> 2.4 mg/h </td> <td> Infusion </td> </tr> </tbody> </table> </body> </html>
train
497,825
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Value ( <i> n </i> = 36) </b> </td> </tr> </thead> <tbody> <tr> <td> Sex (F/M) </td> <td> 28/8 (77.8%/22.2%) </td> </tr> <tr> <td> Age (years) </td> <td> 52.6 ± 10.8 (range 19–76) </td> </tr> <tr> <td> Pathology </td> <td> </td> </tr> <tr> <td> Maxillofacial trauma </td> <td> 13 (36.1%) </td> </tr> <tr> <td> Neck surgery </td> <td> 14 (38.8%) </td> </tr> <tr> <td> Maxillofacial cancer surgery </td> <td> 9 (25.0%) </td> </tr> <tr> <td> Endotracheal tube, oral/nasal </td> <td> 18/18 (50%/50%) </td> </tr> <tr> <td> Duration of endotracheal intubation (days) </td> <td> 2.8 ± 1.6 (range 0.1–10) </td> </tr> <tr> <td> Reintubation ratio </td> <td> 4/36 (11.1%) </td> </tr> <tr> <td> Duration of PAEC <sup> a </sup> (h) </td> <td> 10.4 ± 4.2 (range 4–24) </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Value </b> </td> </tr> </thead> <tbody> <tr> <td> Number of patients </td> <td> 106 </td> </tr> <tr> <td> Age (years) </td> <td> 66.6 ± 18.3 </td> </tr> <tr> <td> Ratio of males to females ( <i> n </i> ) </td> <td> 88/18 </td> </tr> <tr> <td> APACHE II score </td> <td> 20.1 ± 6.5 </td> </tr> <tr> <td> Clinical category ( <i> n </i> [%]) </td> <td> </td> </tr> <tr> <td> Medical </td> <td> 64 (60.3%) </td> </tr> <tr> <td> Cancer </td> <td> 21 (19.8%) </td> </tr> <tr> <td> Neurological </td> <td> 30 (28.2%) </td> </tr> <tr> <td> Surgical </td> <td> 42 (39.7%) </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Qualitative </b> </td> <td colspan="2"> <b> Quantitative </b> </td> </tr> <tr> <td> </td> <td> </td> <td> <b> 10 <sup> 5 </sup> cfu/ml </b> </td> <td> <b> 10 <sup> 6 </sup> cfu/ml </b> </td> </tr> </thead> <tbody> <tr> <td> Sensitivity </td> <td> 81% </td> <td> 65% </td> <td> 26% </td> </tr> <tr> <td> Specificity </td> <td> 23% </td> <td> 48% </td> <td> 78% </td> </tr> <tr> <td> Positive predictive value </td> <td> 18% </td> <td> 21% </td> <td> 20% </td> </tr> <tr> <td> Negative predictive value </td> <td> 86% </td> <td> 87% </td> <td> 83% </td> </tr> <tr> <td> Likelihood ratio of positive test </td> <td> 1.05 </td> <td> 1.25 </td> <td> 1.18 </td> </tr> <tr> <td> Likelihood ratio of negative test </td> <td> 0.83 </td> <td> 0.73 </td> <td> 0.95 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Diagnostic criteria </b> </td> <td> <b> <i> n </i> (%) </b> </td> </tr> </thead> <tbody> <tr> <td> Leukocytosis </td> <td> 26 (68.4%) </td> </tr> <tr> <td> Fever </td> <td> 24 (63.1%) </td> </tr> <tr> <td> Purulent tracheal secretion </td> <td> 22 (57.8%) </td> </tr> <tr> <td> Decrease of at least 10% in PaO <sub> 2 </sub> /FiO <sub> 2 </sub> ratio </td> <td> 16 (42.1%) </td> </tr> <tr> <td> Rales or dullness to percussion on chest examination </td> <td> 9 (23.6%) </td> </tr> <tr> <td> Leucopenia </td> <td> 4 (10.5%) </td> </tr> <tr> <td> Blood positive cultures </td> <td> 4 (10.5%) </td> </tr> <tr> <td> Hypothermia </td> <td> 2 (5.2%) </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Class of antimicrobial </b> </td> <td> <b> Evaluations ( <i> n </i> [%]) </b> </td> </tr> </thead> <tbody> <tr> <td> Glycopeptide </td> <td> 109 (49.7%) </td> </tr> <tr> <td> Antifungical </td> <td> 93 (42.4%) </td> </tr> <tr> <td> Third generation cephalosporin </td> <td> 86 (39.2%) </td> </tr> <tr> <td> Carbapenem </td> <td> 75 (34.2%) </td> </tr> <tr> <td> Clindamicin </td> <td> 34 (15.5%) </td> </tr> <tr> <td> Quinolone </td> <td> 31 (14.1%) </td> </tr> <tr> <td> Metronidazol </td> <td> 26 (11.8%) </td> </tr> <tr> <td> Fourth generation cephalosporin </td> <td> 23 (10.5%) </td> </tr> <tr> <td> Macrolides </td> <td> 23 (10.5%) </td> </tr> <tr> <td> Total </td> <td> 212 (96.8%) </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td colspan="5"> <b> SOFA score </b> </td> </tr> <tr> <td> </td> <td> <b> 0 </b> </td> <td> <b> 1 </b> </td> <td> <b> 2 </b> </td> <td> <b> 3 </b> </td> <td> <b> 4 </b> </td> </tr> </thead> <tbody> <tr> <td> Respiration (PaO <sub> 2 </sub> /FiO <sub> 2 </sub> ratio) </td> <td> &gt;400 </td> <td> ≤ 400 </td> <td> ≤ 300 </td> <td> ≤ 200 with respiratory support </td> <td> ≤ 100 </td> </tr> <tr> <td> Coagulation (platelets × 10 <sup> 3 </sup> /mm <sup> 3 </sup> </td> <td> &gt;150 </td> <td> ≤ 150 </td> <td> ≤ 100 </td> <td> ≤ 50 </td> <td> ≤ 20 </td> </tr> <tr> <td> Liver (bilirubin [mg/dl (μmol/l)]) </td> <td> &lt;1.2 (&lt;20) </td> <td> 1.2–1.9 (20–32) </td> <td> 2.0–5.9 (33–101) </td> <td> 6.0–11.9 (102–204) </td> <td> &gt;12.0 (&gt;204) </td> </tr> <tr> <td> Cardiovascular (hypotension) </td> <td> No hypotension </td> <td> MAP &lt;70 mmHg </td> <td> Dopamine ≤ 5 or dobutamine at any dose </td> <td> Dopamine&gt;5 or adrenaline (epinephrine) ≤ 0.1 noradrenaline (norepinephrine) ≤ 0.1 </td> <td> Dopamine &gt;15 or adrenaline &gt;0.1 noradrenaline &gt;0.1 </td> </tr> <tr> <td> Central nervous system (GCS score) </td> <td> 15 </td> <td> 19–14 </td> <td> 10–12 </td> <td> 6–9 </td> <td> &lt;6 </td> </tr> <tr> <td> Renal (creatine [mg/dl] or urine output) </td> <td> &lt;1.2 </td> <td> 1.2–1.9 </td> <td> 2.0–3.4 </td> <td> 3.5–4.9 or &lt;500 ml/day </td> <td> &gt;5 or &lt;200 ml/day </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Baseline </b> </td> <td colspan="3"> <b> Hours after the start of infusion </b> </td> </tr> <tr> <td> </td> <td> </td> <td> <b> 24 </b> </td> <td> <b> 48 </b> </td> <td> <b> 72 </b> </td> </tr> </thead> <tbody> <tr> <td> Heart rate (beats/min) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 98 ± 24 </td> <td> 99 ± 24 </td> <td> 99 ± 22 </td> <td> 96 ± 22 </td> </tr> <tr> <td> Placebo </td> <td> 95 ± 17 </td> <td> 100 ± 23 </td> <td> 98 ± 23 </td> <td> 97 ± 22 </td> </tr> <tr> <td> Mean arterial pressure (mmHg) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 91 ± 16 </td> <td> 92 ± 13 </td> <td> 89 ± 13 </td> <td> 93 ± 13 </td> </tr> <tr> <td> Placebo </td> <td> 91 ± 18 </td> <td> 93 ± 14 </td> <td> 91 ± 12 </td> <td> 89 ± 11 </td> </tr> <tr> <td> Arterial pH </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 7.34 ± 0.08 </td> <td> 7.36 ± 0.07 </td> <td> 7.33 ± 0.10 </td> <td> 7.36 ± 0.06 </td> </tr> <tr> <td> Placebo </td> <td> 7.35 ± 0.07 </td> <td> 7.37 ± 0.07 </td> <td> 7.34 ± 0.07 </td> <td> 7.37 ± 0.05 </td> </tr> <tr> <td> PaCO <sub> 2 </sub> (torr) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 34.8 ± 12.1 </td> <td> 34.6 ± 11.8 </td> <td> 35.00 ± 9.2 </td> <td> 36.54 ± 11.1 </td> </tr> <tr> <td> Placebo </td> <td> 32.6 ± 10 </td> <td> 33.5 ± 10.2 </td> <td> 36.3 ± 10.13 </td> <td> 34.33 ± 12 </td> </tr> <tr> <td> PaO <sub> 2 </sub> /FiO <sub> 2 </sub> ratio (torr) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 182 ± 68 </td> <td> 186 ± 56 </td> <td> 188 ± 64 </td> <td> 189 ± 76 </td> </tr> <tr> <td> Placebo </td> <td> 184 ± 76 </td> <td> 187 ± 45 </td> <td> 181 ± 68 </td> <td> 185 ± 68 </td> </tr> <tr> <td> SaO <sub> 2 </sub> (%) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 96.1 ± 3 </td> <td> 96.1 ± 3.1 </td> <td> 95.9 ± 3.8 </td> <td> 95.9 ± 4.2 </td> </tr> <tr> <td> Placebo </td> <td> 96.9 ± 3.1 </td> <td> 96.0 ± 3.2 </td> <td> 96.0 ± 2.8 </td> <td> 95.8 ± 3.9 </td> </tr> <tr> <td> Temperature (°C) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 37.8 ± 0.75 </td> <td> 37.2 ± 0.6 </td> <td> 37.8 ± 0.5 </td> <td> 37.9 ± 0.4 </td> </tr> <tr> <td> Placebo </td> <td> 37.6 ± 0.57 </td> <td> 37.8 ± 0.4 </td> <td> 37.6 ± 0.6 </td> <td> 37.8 ± 0.5 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Baseline </b> </td> <td colspan="3"> <b> Hours after the start of infusion </b> </td> </tr> <tr> <td> </td> <td> </td> <td> <b> 24 </b> </td> <td> <b> 48 </b> </td> <td> <b> 72 </b> </td> </tr> </thead> <tbody> <tr> <td> Lactate (mg/dl) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 25.2 ± 4.1 </td> <td> 25.0 ± 3.9 </td> <td> 25.9 ± 5.2 </td> <td> 26.2 ± 3.7 </td> </tr> <tr> <td> Placebo </td> <td> 26.3 ± 3.8 </td> <td> 26.7 ± 2.9 </td> <td> 27.0 ± 3.1 </td> <td> 26.9 ± 4.8 </td> </tr> <tr> <td> Platelets (×10 <sup> 9 </sup> /l) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 192.9 ± 16.5 </td> <td> 193.5 ± 15.0 </td> <td> 178.1 ± 15.4 </td> <td> 182.9 ± 15.6 </td> </tr> <tr> <td> Placebo </td> <td> 188.5 ± 14.4 </td> <td> 190.8 ± 15.1 </td> <td> 188.7 ± 13.3 </td> <td> 190.5 ± 16.7 </td> </tr> <tr> <td> Leucocytes (×10 <sup> 9 </sup> /l) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 14 ± 8.3 </td> <td> 15.8 ± 8.3 </td> <td> 16.0 ± 7.8 </td> <td> 15.9 ± 6.2 </td> </tr> <tr> <td> Placebo </td> <td> 13.5 ± 6.6 </td> <td> 14.7 ± 4.7 </td> <td> 15.7 ± 6.7 </td> <td> 14.8 ± 7.4 </td> </tr> <tr> <td> Bilirubin (mg/dl) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 0.89 ± 0.38 </td> <td> 0.90 ± 0.45 </td> <td> 0.93 ± 0.33 </td> <td> 0.90 ± 0.34 </td> </tr> <tr> <td> Placebo </td> <td> 0.90 ± 0.62 </td> <td> 0.91 ± 0.38 </td> <td> 0.92 ± 0.28 </td> <td> 0.91 ± 0.36 </td> </tr> <tr> <td> Alanine aminotransferase (IU/l) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 35.4 ± 5.5 </td> <td> 36.0 ± 10.8 </td> <td> 35.1 ± 8.6 </td> <td> 36.7 ± 8.4 </td> </tr> <tr> <td> Placebo </td> <td> 35.4 ± 7.4 </td> <td> 35.5 ± 5.2 </td> <td> 36.2 ± 6.0 </td> <td> 37.4 ± 4.9 </td> </tr> <tr> <td> Creatinine (mg/dl) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Lornoxicam </td> <td> 1.13 ± 0.96 </td> <td> 1.15 ± 0.85 </td> <td> 1.2 ± 0.3 </td> <td> 1.28 ± 0.8 </td> </tr> <tr> <td> Placebo </td> <td> 1.01 ± 0.91 </td> <td> 1.1 ± 0.65 </td> <td> 1.08 ± 0.7 </td> <td> 1.1 ± 0.8 </td> </tr> </tbody> </table> </body> </html>
train
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train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Prognostic variable </b> </td> <td> <b> ß </b> </td> <td> <b> SE of ß </b> </td> <td> <b> <i> P </i> </b> </td> </tr> </thead> <tbody> <tr> <td> Duration of surgery </td> <td> 0.062 </td> <td> 0.021 </td> <td> 0.004 </td> </tr> <tr> <td> BMI </td> <td> 0.010 </td> <td> 0.006 </td> <td> 0.072 </td> </tr> <tr> <td> Mean postoperative glucose </td> <td> 0.024 </td> <td> 0.018 </td> <td> 0.195 </td> </tr> <tr> <td> History of cardiac valve disease or arrhythmia </td> <td> 0.058 </td> <td> 0.091 </td> <td> 0.527 </td> </tr> <tr> <td> Transhiatal procedure </td> <td> 0.034 </td> <td> 0.065 </td> <td> 0.599 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Group </b> </td> <td colspan="7"> <b> Time point (hours) </b> </td> </tr> <tr> <td> </td> <td> </td> <td> <b> 0 </b> </td> <td> <b> 1 </b> </td> <td> <b> 2 </b> </td> <td> <b> 3 </b> </td> <td> <b> 4 </b> </td> <td> <b> 5 </b> </td> <td> <b> 6 </b> </td> </tr> </thead> <tbody> <tr> <td> PVRI (dyne·s/cm <sup> 5 </sup> per m <sup> 2 </sup> ) </td> <td> Sham </td> <td> 117 ± 14 </td> <td> 131 ± 19 </td> <td> 141 ± 10 </td> <td> 145 ± 11 </td> <td> 114 ± 21 </td> <td> 133 ± 13 </td> <td> 151 ± 16 </td> </tr> <tr> <td> </td> <td> LPS </td> <td> 115 ± 6 </td> <td> 284 ± 20* <sup> † </sup> </td> <td> 240 ± 21* <sup> † </sup> </td> <td> 198 ± 31 <sup> † </sup> </td> <td> 193 ± 26* <sup> † </sup> </td> <td> 199 ± 23* <sup> † </sup> </td> <td> 182 ± 16* <sup> † </sup> </td> </tr> <tr> <td> </td> <td> OA </td> <td> 103 ± 9 </td> <td> 351 ± 64 <sup> ‡§ </sup> </td> <td> 300 ± 45 <sup> ‡§ </sup> </td> <td> - </td> <td> - </td> <td> - </td> <td> - </td> </tr> <tr> <td> GEDVI (ml/m <sup> 2 </sup> ) </td> <td> Sham </td> <td> 570 ± 46 </td> <td> 601 ± 68 </td> <td> 572 ± 43 </td> <td> 566 ± 12 </td> <td> 661 ± 74 </td> <td> 607 ± 67 </td> <td> 655 ± 60 </td> </tr> <tr> <td> </td> <td> LPS </td> <td> 571 ± 23 </td> <td> 620 ± 57 </td> <td> 564 ± 32 </td> <td> 579 ± 42 </td> <td> 598 ± 38 </td> <td> 624 ± 42 </td> <td> 615 ± 37 </td> </tr> <tr> <td> </td> <td> OA </td> <td> 646 ± 38 </td> <td> 629 ± 60 </td> <td> 590 ± 55 </td> <td> - </td> <td> - </td> <td> - </td> <td> - </td> </tr> <tr> <td> ITBVI (ml/m <sup> 2 </sup> ) </td> <td> Sham </td> <td> 764 ± 62 </td> <td> 806 ± 91 </td> <td> 766 ± 58 </td> <td> 759 ± 16 </td> <td> 886 ± 99 </td> <td> 813 ± 90 </td> <td> 878 ± 81 </td> </tr> <tr> <td> </td> <td> LPS </td> <td> 765 ± 30 </td> <td> 831 ± 76 </td> <td> 756 ± 43 </td> <td> 776 ± 57 </td> <td> 801 ± 51 </td> <td> 836 ± 57 </td> <td> 825 ± 49 </td> </tr> <tr> <td> </td> <td> OA </td> <td> 866 ± 51 </td> <td> 912 ± 42 </td> <td> 790 ± 74 </td> <td> - </td> <td> - </td> <td> - </td> <td> - </td> </tr> <tr> <td> HR (beats/min) </td> <td> Sham </td> <td> 106 ± 6 </td> <td> 104 ± 8 </td> <td> 96 ± 7 </td> <td> 91 ± 5 </td> <td> 99 ± 6 </td> <td> 98 ± 11 </td> <td> 97 ± 5 </td> </tr> <tr> <td> </td> <td> LPS </td> <td> 96 ± 4 </td> <td> 122 ± 6 <sup> † </sup> </td> <td> 109 ± 6 </td> <td> 109 ± 4* <sup> † </sup> </td> <td> 109 ± 8 </td> <td> 122 ± 4* <sup> † </sup> </td> <td> 130 ± 5* <sup> † </sup> </td> </tr> <tr> <td> </td> <td> OA </td> <td> 111 ± 5 </td> <td> 104 ± 13 </td> <td> 102 ± 13 </td> <td> - </td> <td> - </td> <td> - </td> <td> - </td> </tr> <tr> <td> CI (l/min per m <sup> 2 </sup> ) </td> <td> Sham </td> <td> 5.7 ± 0.3 </td> <td> 5.5 ± 0.3 </td> <td> 5.2 ± 0.3 </td> <td> 5.1 ± 0.2 </td> <td> 5.4 ± 0.4 </td> <td> 5.2 ± 0.3 </td> <td> 5.3 ± 0.3 </td> </tr> <tr> <td> </td> <td> LPS </td> <td> 5.7 ± 0.1 </td> <td> 7.3 ± 0.5* <sup> †ll </sup> </td> <td> 5.9 ± 0.2 </td> <td> 5.8 ± 0.3 </td> <td> 5.6 ± 0.4 </td> <td> 6.2 ± 0.3* </td> <td> 6.8 ± 0.2* <sup> † </sup> </td> </tr> <tr> <td> </td> <td> OA </td> <td> 6.1 ± 0.3 </td> <td> 4.5 ± 0.3 <sup> § </sup> </td> <td> 4.6 ± 0.5 </td> <td> - </td> <td> - </td> <td> - </td> <td> - </td> </tr> <tr> <td> MAP (mmHg) </td> <td> Sham </td> <td> 102 ± 5 </td> <td> 101 ± 6 </td> <td> 101 ± 6 </td> <td> 101 ± 5 </td> <td> 102 ± 5 </td> <td> 102 ± 5 </td> <td> 101 ± 4 </td> </tr> <tr> <td> </td> <td> LPS </td> <td> 94 ± 4 </td> <td> 104 ± 5 <sup> † </sup> </td> <td> 105 ± 3 <sup> † </sup> </td> <td> 106 ± 4 <sup> † </sup> </td> <td> 105 ± 3 <sup> † </sup> </td> <td> 104 ± 5 </td> <td> 100 ± 6 </td> </tr> <tr> <td> </td> <td> OA </td> <td> 94 ± 4 </td> <td> 101 ± 2 </td> <td> 104 ± 4 <sup> § </sup> </td> <td> - </td> <td> - </td> <td> - </td> <td> - </td> </tr> <tr> <td> SVRI (dyne·s/cm <sup> 5 </sup> per m <sup> 2 </sup> ) </td> <td> Sham </td> <td> 1453 ± 101 </td> <td> 1496 ± 125 </td> <td> 1589 ± 138 </td> <td> 1536 ± 105 </td> <td> 1579 ± 109 </td> <td> 1607 ± 119 </td> <td> 1681 ± 169 </td> </tr> <tr> <td> </td> <td> LPS </td> <td> 1410 ± 81 </td> <td> 1128 ± 102 <sup> † </sup> </td> <td> 1352 ± 62 </td> <td> 1515 ± 107 </td> <td> 1428 ± 101 </td> <td> 1308 ± 79 </td> <td> 1126 ± 58* <sup> † </sup> </td> </tr> <tr> <td> </td> <td> OA </td> <td> 1266 ± 63 </td> <td> 1847 ± 368 </td> <td> 1670 ± 147 <sup> § </sup> </td> <td> - </td> <td> - </td> <td> - </td> <td> - </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="4"> <b> Study period (hours after establishment of acute lung injury) </b> </td> </tr> <tr> <td> <b> Variables </b> </td> <td> <b> 0 (baseline) </b> </td> <td> <b> 2 </b> </td> <td> <b> 4 </b> </td> <td> <b> 6 </b> </td> </tr> </thead> <tbody> <tr> <td> Minute ventilation (ml/kg per min) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 624 ± 189 </td> <td> 550 ± 152 </td> <td> 590 ± 151 </td> <td> 608 ± 192 </td> </tr> <tr> <td> AV-ECMO </td> <td> 397 ± 96 </td> <td> 214 ± 83 <sup> † </sup> * </td> <td> 222 ± 128 <sup> † </sup> * </td> <td> 256 ± 155 <sup> † </sup> * </td> </tr> <tr> <td> MAP (mmHg) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 89.6 ± 12.2 </td> <td> 81.5 ± 10.1 </td> <td> 83.8 ± 17.0 </td> <td> 82.5 ± 9.0 </td> </tr> <tr> <td> AV-ECMO </td> <td> 92.5 ± 10.6 </td> <td> 90.0 ± 16.2 </td> <td> 73.5 ± 25.0 </td> <td> 74.5 ± 40 </td> </tr> <tr> <td> PAP (mmHg) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 20.8 ± 6.4 </td> <td> 23.1 ± 7.7 </td> <td> 22.6 ± 3.7 </td> <td> 18.6 ± 6.8 </td> </tr> <tr> <td> AV-ECMO </td> <td> 19.0 ± 5.7 </td> <td> 24.7 ± 7.5* </td> <td> 26.2 ± 7.8* </td> <td> 26.2 ± 9.3* </td> </tr> <tr> <td> Cardiac output (ml/kg per min) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 164 ± 45 </td> <td> 165 ± 28 </td> <td> 189 ± 62 </td> <td> 194 ± 54 </td> </tr> <tr> <td> AV-ECMO </td> <td> 144 ± 56 </td> <td> 177 ± 30 </td> <td> 143 ± 47 </td> <td> 184 ± 54 </td> </tr> <tr> <td> Oxygen consumption (ml/kg per min) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 9.6 ± 2.4 </td> <td> 9.2 ± 1.5 </td> <td> 10.1 ± 3.4 </td> <td> 8.9 ± 3.7 </td> </tr> <tr> <td> AV-ECMO </td> <td> 7.1 ± 1.7 </td> <td> 9.7 ± 2.3 </td> <td> 8.1 ± 1.3 </td> <td> 8.2 ± 3.7 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="4"> <b> Study period (hours after establishment of acute lung injury) </b> </td> </tr> <tr> <td> <b> Variable </b> </td> <td> <b> 0 (baseline) </b> </td> <td> <b> 2 </b> </td> <td> <b> 4 </b> </td> <td> <b> 6 </b> </td> </tr> </thead> <tbody> <tr> <td> PaO <sub> 2 </sub> (mmHg) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 131 ± 90 </td> <td> 207 ± 171 </td> <td> 231 ± 175 </td> <td> 221 ± 189 </td> </tr> <tr> <td> AV-ECMO </td> <td> 174 ± 100 </td> <td> 95 ± 29 </td> <td> 77 ± 17* </td> <td> 94 ± 76 </td> </tr> <tr> <td> PaCO <sub> 2 </sub> (mmHg) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 41.3 ± 3.1 </td> <td> 43.4 ± 8.3 </td> <td> 38.9 ± 10.3 </td> <td> 37.0 ± 7.1 </td> </tr> <tr> <td> AV-ECMO </td> <td> 34.8 ± 2.3** </td> <td> 35.1 ± 8.5 </td> <td> 37.1 ± 7.8 </td> <td> 37.8 ± 5.7 </td> </tr> <tr> <td> pH </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 7.263 ± 0.05 </td> <td> 7.237 ± 0.05 </td> <td> 7.286 ± 0.10 </td> <td> 7.289 ± 0.08 </td> </tr> <tr> <td> AV-ECMO </td> <td> 7.322 ± 0.04* </td> <td> 7.277 ± 0.15 </td> <td> 7.235 ± 0.10 </td> <td> 7.207 ± 0.14 </td> </tr> <tr> <td> HCO <sub> 3 </sub> <sup> - </sup> (mmol/l) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 17.0 ± 3.1 </td> <td> 16.8 ± 3.2 </td> <td> 16.7 ± 2.7 </td> <td> 15.9 ± 3.3 </td> </tr> <tr> <td> AV-ECMO </td> <td> 17.2 ± 2.4 </td> <td> 15.7 ± 2.3 </td> <td> 15.7 ± 5.4 </td> <td> 14.6 ± 4.6 </td> </tr> <tr> <td> Arterial Hb-O <sub> 2 </sub> (%) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 91.8 ± 8.1 </td> <td> 89.2 ± 14.9 </td> <td> 94.0 ± 4.9 </td> <td> 88.9 ± 18.4 </td> </tr> <tr> <td> AV-ECMO </td> <td> 90.7 ± 16.5 </td> <td> 89.0 ± 9.9 </td> <td> 84.4 ± 7.0 </td> <td> 74.0 ± 24.8 </td> </tr> <tr> <td> O <sub> 2 </sub> extraction (%) </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> CMV </td> <td> 42.4 ± 15.6 </td> <td> 37.6 ± 9.2 </td> <td> 47.2 ± 11.5 </td> <td> 41.2 ± 6.9 </td> </tr> <tr> <td> AV-ECMO </td> <td> 41.6 ± 11.9 </td> <td> 37.3 ± 14.2 </td> <td> 49.3 ± 21.0 </td> <td> 43.3 ± 21.7 </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Type of support </b> </td> <td colspan="2"> <b> Group </b> </td> <td> <b> <i> P </i> <sup> a </sup> </b> </td> </tr> <tr> <td> </td> <td> <b> CMV ( <i> n </i> = 8) </b> </td> <td> <b> AV-ECMO ( <i> n </i> = 9) </b> </td> <td> </td> </tr> </thead> <tbody> <tr> <td> Lactated Ringer's (10 ml/kg) </td> <td> 2 </td> <td> 8 </td> <td> 0.015 </td> </tr> <tr> <td> Epinephrine (0.5–2 μg/kg per min) </td> <td> 1 </td> <td> 6 </td> <td> 0.049 </td> </tr> <tr> <td> Dopamine (5 μg/kg per min) </td> <td> 1 </td> <td> 6 </td> <td> 0.049 </td> </tr> <tr> <td> Bicarbonate (1 mEq/kg bolus) </td> <td> 1 </td> <td> 6 </td> <td> 0.049 </td> </tr> <tr> <td> Surviving/nonsurviving </td> <td> 6/2 </td> <td> 4/5 </td> <td> 0.333 </td> </tr> <tr> <td> Total number of resuscitative measures in surviving lambs </td> <td> 2 ( <i> n </i> = 6) </td> <td> 12 ( <i> n </i> = 4) </td> <td> 0.001 </td> </tr> <tr> <td> Cause of death </td> <td> Prolonged hypotension with MAP &lt;30 mmHg </td> <td> Prolonged hypotension with MAP &lt;30 mmHg and AV shunt &lt;5% of CO </td> <td> </td> </tr> </tbody> </table> </body> </html>
train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Patient number/sex </b> </td> <td> <b> Age (years) </b> </td> <td> <b> Length (cm) </b> </td> <td> <b> Weight (kg) </b> </td> <td> <b> Diagnosis </b> </td> <td> <b> Propofol infusion <sup> a </sup> (mg/kg per hour) </b> </td> <td> <b> Duration of infusion <sup> b </sup> (hours) </b> </td> <td> <b> Opioids <sup> c </sup> </b> </td> </tr> </thead> <tbody> <tr> <td> 1/M </td> <td> 59 </td> <td> 180 </td> <td> 86 </td> <td> Thoracic aorta dissection </td> <td> 1.63 </td> <td> 31 </td> <td> Oxycodon 10 mg </td> </tr> <tr> <td> 2/M </td> <td> 53 </td> <td> 180 </td> <td> 130 </td> <td> Acute myocardial infarction </td> <td> 0.62 </td> <td> 11 </td> <td> Fentanyl 0.100 mg/hour </td> </tr> <tr> <td> 3/M </td> <td> 47 </td> <td> 173 </td> <td> 68 </td> <td> Pneumonia and sepsis (streptococcal pneumonia) </td> <td> 1.18 </td> <td> 13 </td> <td> Oxycodon 3 mg </td> </tr> <tr> <td> 4/F </td> <td> 47 </td> <td> 170 </td> <td> 68 </td> <td> Multitrauma (renal rupture, pelvic fracture) </td> <td> 1.76 </td> <td> 20 </td> <td> Oxycodon 10 mg </td> </tr> <tr> <td> 5/M </td> <td> 61 </td> <td> 169 </td> <td> 96 </td> <td> Ruptured abdominal aortic aneurysm </td> <td> 2.08 </td> <td> 19 </td> <td> Fentanyl 0.100 mg/hour </td> </tr> <tr> <td> 6/M </td> <td> 76 </td> <td> 174 </td> <td> 73 </td> <td> Acute myocardial infarction and peritonitis </td> <td> 2.47 </td> <td> 66 </td> <td> Fentanyl 0.100 mg/hour </td> </tr> <tr> <td> 7/F </td> <td> 72 </td> <td> 160 </td> <td> 70 </td> <td> Acute lung injury and status post-AVR+CABG </td> <td> 1.71 </td> <td> 10 </td> <td> Oxycodon 5 mg </td> </tr> <tr> <td> 8/M </td> <td> 66 </td> <td> 176 </td> <td> 90 </td> <td> Acute lung injury and status post-CABG </td> <td> 4.44 </td> <td> 46 </td> <td> Fentanyl 0.150 mg/hour </td> </tr> <tr> <td> 9/M </td> <td> 68 </td> <td> 162 </td> <td> 79 </td> <td> Wound infection post-CABG </td> <td> 3.04 </td> <td> 112 </td> <td> Oxycodon 35 mg </td> </tr> <tr> <td> 10/M </td> <td> 64 </td> <td> 164 </td> <td> 65 </td> <td> Peritonitis and septic shock </td> <td> 1.85 </td> <td> 13 </td> <td> Fentanyl 0.200 mg </td> </tr> <tr> <td> 11/F </td> <td> 70 </td> <td> 162 </td> <td> 89 </td> <td> Acute myocarial infarction and status post-CABG </td> <td> 0.67 </td> <td> 16 </td> <td> Oxacodon 5 mg </td> </tr> <tr> <td> 12/M </td> <td> 83 </td> <td> 167 </td> <td> 65 </td> <td> Peritonitis </td> <td> 2.15 </td> <td> 19 </td> <td> Fentanyl 0.075 mg </td> </tr> <tr> <td> 13/M </td> <td> 72 </td> <td> 176 </td> <td> 96 </td> <td> Sternal dehiscence post-CABG </td> <td> 1.46 </td> <td> 14 </td> <td> Oxycodon 36 mg </td> </tr> <tr> <td> 14/M </td> <td> 76 </td> <td> 183 </td> <td> 77 </td> <td> Acute myocarial infarction and pulmonary haemorrhage </td> <td> 1.04 </td> <td> 18 </td> <td> Oxycodon 10 mg </td> </tr> <tr> <td> 15/F </td> <td> 71 </td> <td> 162 </td> <td> 58 </td> <td> Wound infection post-CABG+AVR </td> <td> 1.72 </td> <td> 19 </td> <td> Fentanyl 0.150 mg, oxycodon 29 mg </td> </tr> <tr> <td> 16/M </td> <td> 77 </td> <td> 167 </td> <td> 73 </td> <td> Acute respiratory distress syndrome </td> <td> 2.74 </td> <td> 69 </td> <td> Fentanyl 0.825 mg, oxycodon 15 mg </td> </tr> <tr> <td> 17/F </td> <td> 50 </td> <td> 170 </td> <td> 75 </td> <td> Low cardiac output (status post-CABG) </td> <td> 1.60 </td> <td> 86 </td> <td> Fentanyl 0.150 mg/hour </td> </tr> <tr> <td> 18/F </td> <td> 59 </td> <td> 165 </td> <td> 60 </td> <td> Acute lung injury and septic shock </td> <td> 1.67 </td> <td> 12 </td> <td> Oxycodon 3 mg </td> </tr> <tr> <td> 19/M </td> <td> 71 </td> <td> 170 </td> <td> 80 </td> <td> Acute myocarial infarction and pulmonary oedema </td> <td> 1.50 </td> <td> 14 </td> <td> Oxycodon 18 mg </td> </tr> <tr> <td> Mean </td> <td> 65 </td> <td> 170 </td> <td> 79 </td> <td> - </td> <td> 1.91 </td> <td> 31 </td> <td> - </td> </tr> <tr> <td> SD </td> <td> 11 </td> <td> 7 </td> <td> 16 </td> <td> - </td> <td> 0.88 </td> <td> 29 </td> <td> - </td> </tr> </tbody> </table> </body> </html>
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train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Characteristic </b> </td> <td> <b> Non-survivors ( <i> n </i> = 22) </b> </td> <td> <b> Survivors ( <i> n </i> = 34) </b> </td> <td> <b> <i> P </i> </b> </td> </tr> </thead> <tbody> <tr> <td> Age, years (mean ± SD) </td> <td> 62 ± 12.0 </td> <td> 51 ± 12.8 </td> <td> 0.002 </td> </tr> <tr> <td> APACHE II score (mean ± SD) </td> <td> 25 ± 8.5 </td> <td> 18 ± 10.6 </td> <td> 0.019 </td> </tr> <tr> <td> Ranson score (mean ± SD) </td> <td> 6.3 ± 2.03 </td> <td> 5.7 ± 2.09 </td> <td> 0.36 </td> </tr> <tr> <td> Male gender </td> <td> 15 (68%) </td> <td> 20 (59%) </td> <td> 0.48 </td> </tr> <tr> <td> CRP at admission, mg/dl (mean ± SD) </td> <td> 176 ± 162.3 </td> <td> 170 ± 142.2 </td> <td> 0.90 </td> </tr> <tr> <td colspan="4"> Organ dysfunction </td> </tr> <tr> <td> Respiratory insufficiency </td> <td> 22 (100%) </td> <td> 21 (62%) </td> <td> 0.001 </td> </tr> <tr> <td> Acute renal failure </td> <td> 22 (100%) </td> <td> 17 (50%) </td> <td> &lt;0.001 </td> </tr> <tr> <td> Cardiovascular failure </td> <td> 20 (91%) </td> <td> 12 (35%) </td> <td> &lt;0.001 </td> </tr> <tr> <td> Sterile necrosis </td> <td> 17 (77%) </td> <td> 13 (38.2%) </td> <td> 0.004 </td> </tr> <tr> <td> SOFA score at surgery (median and IQR) </td> <td> 4 (9–13) </td> <td> 2 (2–7) </td> <td> 0.005 </td> </tr> <tr> <td> MODS as indication for surgery </td> <td> 8 (36%) </td> <td> 4 (12%) </td> <td> 0.045 </td> </tr> <tr> <td> Early surgical intervention </td> <td> 12 (55%) </td> <td> 10 (29%) </td> <td> 0.06 </td> </tr> <tr> <td> Interval from diagnosis to surgery, days (median and IQR) </td> <td> 11 (4–22) </td> <td> 18 (12–29) </td> <td> 0.09 </td> </tr> </tbody> </table> </body> </html>
train
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train
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train
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Characteristics </b> </td> <td> <b> Total ( <i> n </i> = 163) </b> </td> <td> <b> Successful weaning ( <i> n </i> = 78) </b> </td> <td> <b> Failure to wean ( <i> n </i> = 85) </b> </td> <td> <b> <i> P </i> </b> </td> </tr> </thead> <tbody> <tr> <td> Age </td> <td> 70.3 ± 15.1 </td> <td> 68.6 ± 15.4 </td> <td> 71.8 ± 14.8 </td> <td> 0.2 </td> </tr> <tr> <td> Sex (male/female) </td> <td> 93/70 </td> <td> 49/29 </td> <td> 44/41 </td> <td> 0.2 </td> </tr> <tr> <td> APACHE II score </td> <td> 20.0 ± 7.2 </td> <td> 19.6 ± 7.1 </td> <td> 21.3 ± 7.6 </td> <td> 0.1 </td> </tr> <tr> <td> Comorbid conditions </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> Hypertension </td> <td> 63 (38.7%) </td> <td> 34 (43.6%) </td> <td> 29 (34.1%) </td> <td> 0.3 </td> </tr> <tr> <td> Diabetes mellitus </td> <td> 50 (30.7%) </td> <td> 27 (34.6%) </td> <td> 23 (27.1%) </td> <td> 0.3 </td> </tr> <tr> <td> COPD </td> <td> 34 (20.9%) </td> <td> 12 (15.4%) </td> <td> 22 (25.9%) </td> <td> 0.1 </td> </tr> <tr> <td> Malignancy </td> <td> 34 (20.9%) </td> <td> 14 (17.9%) </td> <td> 20 (23.5%) </td> <td> 0.4 </td> </tr> <tr> <td> Congestive heart failure </td> <td> 32 (19.6%) </td> <td> 19 (24.4%) </td> <td> 13 (15.3%) </td> <td> 0.2 </td> </tr> <tr> <td> Renal insufficiency </td> <td> 32 (19.6%) </td> <td> 15 (19.2%) </td> <td> 17 (20.0%) </td> <td> 1.0 </td> </tr> <tr> <td> Stroke </td> <td> 25 (15.3%) </td> <td> 16 (20.5%) </td> <td> 9 (10.6%) </td> <td> 0.09 </td> </tr> <tr> <td> Autoimmune disease </td> <td> 12 (7.4%) </td> <td> 5 (6.4%) </td> <td> 7 (8.2%) </td> <td> 0.8 </td> </tr> <tr> <td> Cancer metastatic to lung </td> <td> 8 (4.9%) </td> <td> 1 (0.01%) </td> <td> 7 (4.5%) </td> <td> 0.07 </td> </tr> </tbody> </table> </body> </html>
train
417,034
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Parameter </b> </td> <td> <b> Total ( <i> n </i> = 163) </b> </td> <td> <b> Successful weaning ( <i> n </i> = 78) </b> </td> <td> <b> Failure to wean ( <i> n </i> = 85) </b> </td> <td> <b> <i> P </i> </b> </td> </tr> </thead> <tbody> <tr> <td> Albumin (g/dl) </td> <td> 2.7 ± 0.5 </td> <td> 2.7 ± 0.4 </td> <td> 2.6 ± 0.5 </td> <td> 0.2 </td> </tr> <tr> <td> AST (U/l) </td> <td> 44.2 ± 49.6 </td> <td> 47.5 ± 63.2 </td> <td> 41.2 ± 32.5 </td> <td> 0.4 </td> </tr> <tr> <td> Creatinine (mg/dl) </td> <td> 1.5 ± 1.7 </td> <td> 1.4 ± 1.8 </td> <td> 1.6 ± 1.6 </td> <td> 0.6 </td> </tr> <tr> <td> Haemoglobin (g/dl) </td> <td> 10.5 ± 1.3 </td> <td> 10.6 ± 1.3 </td> <td> 10.4 ± 1.2 </td> <td> 0.4 </td> </tr> <tr> <td> WBC count (cells/μl) </td> <td> 11993 ± 5474 </td> <td> 11110 ± 4570 </td> <td> 12803 ± 6104 </td> <td> 0.05 </td> </tr> <tr> <td> Platelet (cell × 10 <sup> 3 </sup> /μl) </td> <td> 192.2 ± 113.7 </td> <td> 217.9 ± 116.3 </td> <td> 168.7 ± 106.4 </td> <td> 0.005 </td> </tr> <tr> <td> PaO <sub> 2 </sub> /FiO <sub> 2 </sub> ratio </td> <td> 261.5 ± 93.6 </td> <td> 284.5 ± 85.5 </td> <td> 240.7 ± 96.1 </td> <td> 0.003 </td> </tr> <tr> <td> pH </td> <td> 7.4 ± 0.1 </td> <td> 7.4 ± 0.1 </td> <td> 7.4 ± 0.1 </td> <td> 0.2 </td> </tr> <tr> <td> Paco <sub> 2 </sub> (mmHg) </td> <td> 40.9 ± 11.3 </td> <td> 39.5 ± 7.5 </td> <td> 42.2 ± 13.8 </td> <td> 0.1 </td> </tr> </tbody> </table> </body> </html>
train
469,722
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Outcomes </b> </td> <td> <b> Total ( <i> n </i> = 163) </b> </td> <td> <b> Successful weaning ( <i> n </i> = 78) </b> </td> <td> <b> Failure to wean ( <i> n </i> = 85) </b> </td> <td> <b> <i> P </i> </b> </td> </tr> </thead> <tbody> <tr> <td> ICU mortality ( <i> n </i> [%]) </td> <td> 31 (19.0%) </td> <td> 2 (2.6%) </td> <td> 29 (34.1%) </td> <td> &lt;0.001 </td> </tr> <tr> <td> In-hospital mortality ( <i> n </i> [%]) </td> <td> 78 (47.9%) </td> <td> 15 (19.2%) </td> <td> 63 (74.1%) </td> <td> &lt;0.001 </td> </tr> <tr> <td> Intubation period (days) </td> <td> 18.5 ± 10.9 </td> <td> 16.3 ± 10.5 </td> <td> 20.4 ± 10.9 </td> <td> 0.02 </td> </tr> <tr> <td> Overall ICU stay (days) </td> <td> 29.7 ± 15.8 </td> <td> 25.4 ± 13.8 </td> <td> 33.7 ± 16.4 </td> <td> 0.001 </td> </tr> <tr> <td> Post-tracheostomy ICU stay (days) </td> <td> 11.9 ± 9.9 </td> <td> 9.7 ± 7.6 </td> <td> 14.0 ± 11.3 </td> <td> 0.005 </td> </tr> <tr> <td> Post-tracheostomy MV period (days) </td> <td> 27.3 ± 40.7 </td> <td> 10.5 ± 12.6 </td> <td> 42.6 ± 50.4 </td> <td> 0.001 </td> </tr> <tr> <td> Post-tracheostomy pneumonia </td> <td> 109 (66.9%) </td> <td> 46 (59.0%) </td> <td> 63 (74.1%) </td> <td> 0.05 </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Patient (sex, age [years]) </b> </td> <td> <b> Diagnosis/pathology </b> </td> <td> <b> Disease duration (years) </b> </td> <td> <b> Medication </b> </td> </tr> </thead> <tbody> <tr> <td> 1 (male, 69) </td> <td> RA </td> <td> 37 </td> <td> Auranofin, NSAID </td> </tr> <tr> <td> 2 (female, 41) </td> <td> RA </td> <td> 23 </td> <td> NSAID </td> </tr> <tr> <td> 3 (female, 51) </td> <td> RA </td> <td> 10 </td> <td> NSAID, analgesic </td> </tr> <tr> <td> 4 (female, 79) </td> <td> RA </td> <td> 4 </td> <td> Methotrexate, NSAID, steroid </td> </tr> <tr> <td> 5 (female, 70) </td> <td> RA </td> <td> 8 </td> <td> Penicillamine, steroid, NSAID </td> </tr> <tr> <td> 6 (female, 63) </td> <td> RA + secondary osteoarthritis </td> <td> 39 </td> <td> Methotrexate, steroid, analgesic </td> </tr> <tr> <td> 7 (female, 33) </td> <td> juvenile chronic arthritis </td> <td> 20 </td> <td> NSAID </td> </tr> <tr> <td> 8 (female, 66) </td> <td> RA </td> <td> 38 </td> <td> NSAID, analgesic </td> </tr> <tr> <td> 1 (female, 50) </td> <td> Articular cartilage damage </td> <td> &lt;1 </td> <td> NSAID, analgesic </td> </tr> <tr> <td> 2 (male, 44) </td> <td> Meniscal tear </td> <td> &lt;1 </td> <td> - </td> </tr> <tr> <td> 3 (male, 42) </td> <td> Meniscal tear and articular cartilage damage </td> <td> 4 </td> <td> - </td> </tr> <tr> <td> 4 (male, 60) </td> <td> Meniscal degeneration </td> <td> &lt;1 </td> <td> - </td> </tr> <tr> <td> 5 (male, 52) </td> <td> Articular cartilage degeneration </td> <td> 1 </td> <td> - </td> </tr> <tr> <td> 6 (male, 46) </td> <td> Meniscal tear </td> <td> &lt;1 </td> <td> - </td> </tr> <tr> <td> 7 (male, 53) </td> <td> Meniscal degeneration </td> <td> &lt;1 </td> <td> - </td> </tr> <tr> <td> 8 (male, 38) </td> <td> Meniscal tear </td> <td> 1 </td> <td> Steroid </td> </tr> <tr> <td> 9 (male, 43) </td> <td> Articular cartilage degeneration </td> <td> &lt;1 </td> <td> - </td> </tr> <tr> <td> 1 (female, 91) </td> <td> RA </td> <td> &lt;1 </td> <td> Analgesic </td> </tr> <tr> <td> 2 (female, 56) </td> <td> RA </td> <td> &lt;1 </td> <td> NSAID, steroid, methotrexate </td> </tr> <tr> <td> 3 (male, 67) </td> <td> RA </td> <td> </td> <td> - </td> </tr> <tr> <td> 4 (male, 67) </td> <td> RA </td> <td> 4 </td> <td> Analgesic, NSAID, methotrexate </td> </tr> </tbody> </table> </body> </html>
train
443,164
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> mRNA </b> </td> <td> <b> Product </b> </td> <td> <b> Sequence </b> </td> <td> <b> Size (base pairs) </b> </td> <td> <b> Accession number </b> </td> </tr> </thead> <tbody> <tr> <td> L27 </td> <td> Forward </td> <td> 5'-GACGCAAAGCTGTCATCGTG-3' </td> <td> 344 </td> <td> BC007273 </td> </tr> <tr> <td> </td> <td> Reverse </td> <td> 5'-GCAGTTTCTGGAAGAACCAC-3' </td> <td> </td> <td> </td> </tr> <tr> <td> CXCR5 </td> <td> Forward </td> <td> 5'-TGA CCT GAG GAA GCG TGA AG-3' </td> <td> 639 </td> <td> NM001716 </td> </tr> <tr> <td> </td> <td> Reverse </td> <td> 5'-CGT GAA GAC ACT CTC ACG TG-3' </td> <td> </td> <td> </td> </tr> </tbody> </table> </body> </html>
train
541,912
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Gene </b> </td> <td> <b> GenBank accession no. </b> </td> <td> <b> Primers (5'→3') </b> </td> <td> <b> Conc. (nM) </b> </td> <td> <b> Probe (5'→3') </b> </td> <td> <b> MgCl <sub> 2 </sub> (mM) </b> </td> </tr> </thead> <tbody> <tr> <td> <i> GAPDH </i> </td> <td> NM_002046 </td> <td> Forward: GAAGGTGAAGGTCGGAGTC </td> <td> 50 </td> <td> CAAGCTTCCCGTTCTCAGCC </td> <td> 5.5 </td> </tr> <tr> <td> </td> <td> </td> <td> Reverse: GAAGATGGTGATGGGATTTC </td> <td> 900 </td> <td> </td> <td> </td> </tr> <tr> <td> <i> TOB1 </i> </td> <td> NM_005749 </td> <td> Forward: TCTGCTGCTGTAAGCCCTACCT </td> <td> 300 </td> <td> CGGTCCACTCAGCCTTTAACCTTTACCACT </td> <td> 6.5 </td> </tr> <tr> <td> </td> <td> </td> <td> Reverse: TTCATTTTGGTAGAGCCGAACTT </td> <td> 900 </td> <td> </td> <td> </td> </tr> <tr> <td> <i> Ki-67 </i> </td> <td> NM_002417 </td> <td> Forward: CAGTGATCAACGCCGTAGGTC </td> <td> 900 </td> <td> CTTCCAGCAGCAAATCTCAGACAGAGGTTC </td> <td> 6.0 </td> </tr> <tr> <td> </td> <td> </td> <td> Reverse: TCGGCTGATAGACACTCTCTTTTG </td> <td> 900 </td> <td> </td> <td> </td> </tr> <tr> <td> <i> COL2A1 </i> </td> <td> NM_001844 </td> <td> Forward:CAACACTGCCAACGTCCAGAT </td> <td> 50 </td> <td> ACCTTCCTACGCCTGCTGTCCACG </td> <td> 5.5 </td> </tr> <tr> <td> </td> <td> </td> <td> Reverse: CTGCTTCGTCCAGATAGGCAAT </td> <td> 300 </td> <td> </td> <td> </td> </tr> <tr> <td> <i> MMP-13 </i> </td> <td> NM_002427 </td> <td> Forward: TCCTCTTCTTGAGCTGGACTCATT </td> <td> 900 </td> <td> TCCTCAGACAAATCATCTTCATCACCACCAC </td> <td> 7.0 </td> </tr> <tr> <td> </td> <td> </td> <td> Reverse: CGCTCTGCAAACTGGAGGTC </td> <td> 50 </td> <td> </td> <td> </td> </tr> </tbody> </table> </body> </html>
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Downregulated genes </b> </td> <td> <b> GenBank accession no. </b> </td> <td> <b> OA:N </b> </td> <td> <b> OA </b> </td> <td> <b> N </b> </td> <td> <b> Upregulated genes </b> </td> <td> <b> GenBank accession no. </b> </td> <td> <b> OA:N </b> </td> <td> <b> OA </b> </td> <td> <b> N </b> </td> </tr> </thead> <tbody> <tr> <td> <i> CHI3L1 </i> </td> <td> NM_001276 </td> <td> 0.02 </td> <td> 0.001 </td> <td> 0.05 </td> <td> <i> COMP </i> </td> <td> NM_000095 </td> <td> 2.07 </td> <td> 19.93 </td> <td> 10.68 </td> </tr> <tr> <td> <i> Follistatin </i> </td> <td> NM_006350 </td> <td> 0.06 </td> <td> 0.01 </td> <td> 0.22 </td> <td> <i> BGLAP </i> </td> <td> X53698 </td> <td> 2.18 </td> <td> 0.13 </td> <td> 0.07 </td> </tr> <tr> <td> <i> APOD </i> </td> <td> NM_001647 </td> <td> 0.08 </td> <td> 1.10 </td> <td> 15.68 </td> <td> <i> TIMP1 </i> </td> <td> X03124 </td> <td> 2.20 </td> <td> 12.18 </td> <td> 6.34 </td> </tr> <tr> <td> <i> EDR2 </i> </td> <td> NM_004427 </td> <td> 0.09 </td> <td> 0.09 </td> <td> 0.86 </td> <td> <i> ARGBP2 </i> </td> <td> AF049884 </td> <td> 2.25 </td> <td> 0.11 </td> <td> 0.04 </td> </tr> <tr> <td> <i> MMP3 </i> </td> <td> X05232 </td> <td> 0.09 </td> <td> 1.04 </td> <td> 10.28 </td> <td> <i> FGF18 </i> </td> <td> AF075292 </td> <td> 2.35 </td> <td> 0.40 </td> <td> 0.16 </td> </tr> <tr> <td> <i> Tob1 </i> </td> <td> NM_005749 </td> <td> 0.14 </td> <td> 0.12 </td> <td> 0.96 </td> <td> <i> Fibronectin </i> </td> <td> M10905 </td> <td> 2.36 </td> <td> 19.08 </td> <td> 9.46 </td> </tr> <tr> <td> <i> SLC3A2 </i> </td> <td> NM_002394 </td> <td> 0.19 </td> <td> 0.04 </td> <td> 0.22 </td> <td> <i> Frizzled homolog 1 </i> </td> <td> NM_003505 </td> <td> 2.37 </td> <td> 0.05 </td> <td> 0.03 </td> </tr> <tr> <td> <i> MAPK7 </i> </td> <td> NM_002749 </td> <td> 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AF327402 </td> <td> 0.28 </td> <td> 0.12 </td> <td> 0.43 </td> <td> <i> ADAMTS1 </i> </td> <td> NM_006988 </td> <td> 2.70 </td> <td> 0.12 </td> <td> 0.05 </td> </tr> <tr> <td> <i> UBC </i> </td> <td> M26880 </td> <td> 0.31 </td> <td> 3.29 </td> <td> 11.04 </td> <td> <i> CHM-I </i> </td> <td> NM_007015 </td> <td> 2.88 </td> <td> 0.36 </td> <td> 0.09 </td> </tr> <tr> <td> <i> Integrin α5 </i> </td> <td> NM_002205 </td> <td> 0.35 </td> <td> 0.36 </td> <td> 1.17 </td> <td> <i> MMP-13 </i> </td> <td> X75308 </td> <td> 2.88 </td> <td> 0.13 </td> <td> 0.06 </td> </tr> <tr> <td> <i> GNB2L1 </i> </td> <td> NM_006098 </td> <td> 0.38 </td> <td> 1.15 </td> <td> 2.39 </td> <td> <i> COL6A1 </i> </td> <td> X15880 </td> <td> 2.89 </td> <td> 9.55 </td> <td> 2.94 </td> </tr> <tr> <td> <i> NF-κB_p65 </i> </td> <td> Q04206 </td> <td> 0.40 </td> <td> 0.04 </td> <td> 0.10 </td> <td> <i> COL11A1 </i> </td> <td> J04177 </td> <td> 3.84 </td> <td> 0.52 </td> <td> 0.16 </td> </tr> <tr> <td> <i> Pim-1 </i> </td> 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TG-interacting factor </i> </td> <td> NM_003244 </td> <td> 0.47 </td> <td> 0.05 </td> <td> 0.10 </td> <td> <i> COL6A3 </i> </td> <td> NM_004369 </td> <td> 8.70 </td> <td> 3.49 </td> <td> 0.45 </td> </tr> <tr> <td> <i> Phosphomannomutase 1 </i> </td> <td> U86070 </td> <td> 0.47 </td> <td> 0.11 </td> <td> 0.26 </td> <td> <i> COL1A2 </i> </td> <td> X55525 </td> <td> 14.25 </td> <td> 4.21 </td> <td> 0.33 </td> </tr> <tr> <td> <i> DLX5 </i> </td> <td> NM_005221 </td> <td> 0.47 </td> <td> 0.04 </td> <td> 0.08 </td> <td> <i> TGFBI </i> </td> <td> NM_000358 </td> <td> 14.67 </td> <td> 2.41 </td> <td> 0.18 </td> </tr> <tr> <td> <i> Biglycan </i> </td> <td> NM_001711 </td> <td> 0.49 </td> <td> 0.21 </td> <td> 0.50 </td> <td> <i> COL3A1 </i> </td> <td> X14420 </td> <td> 31.33 </td> <td> 15.33 </td> <td> 0.52 </td> </tr> <tr> <td> TP53 </td> <td> NM_000546 </td> <td> 0.50 </td> <td> 0.14 </td> <td> 0.34 </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> </tbody> </table> </body> </html>
train
219,890
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> </td> <td colspan="2"> <b> Mean fluorescence of CXCR3 <sup> a </sup> </b> </td> <td> </td> </tr> <tr> <td> <b> Patient no. </b> </td> <td> <b> In PB cells </b> </td> <td> <b> In SF cells </b> </td> <td> <b> D/s <sup> b </sup> </b> </td> </tr> </thead> <tbody> <tr> <td> 1 </td> <td> 35.79 </td> <td> 55.8 </td> <td> 36.5 </td> </tr> <tr> <td> 2 </td> <td> 23.02 </td> <td> 77.13 </td> <td> 36 </td> </tr> <tr> <td> 3 </td> <td> 20.27 </td> <td> 48.88 </td> <td> 22.4 </td> </tr> <tr> <td> 4 </td> <td> 15.84 </td> <td> 27.75 </td> <td> 34 </td> </tr> <tr> <td> 5 </td> <td> 16.44 </td> <td> 20.59 </td> <td> 20.2 </td> </tr> </tbody> </table> </body> </html>
train
456,032
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Course </b> </td> <td> <b> No. of patients </b> </td> <td> <b> Age (years) </b> </td> <td> <b> Disease duration (years) </b> </td> <td> <b> No. of joints with active/limited range of motion </b> </td> <td> <b> PGI </b> </td> <td> <b> ESR (mm/h) </b> </td> <td> <b> Treatment; <i> n </i> </b> </td> </tr> </thead> <tbody> <tr> <td> Polyarticular </td> <td> 10 </td> <td> 10.9 (3.3–16.1) </td> <td> 3.2 (0.5–11.2) </td> <td> 6 (1–16)/12.2 (1–29) </td> <td> 8.3 (6–10) </td> <td> 65 (23–131) </td> <td> NSAID, MTX; 7 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> NSAID, CS, MTX; 2 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> NSAID alone; 1 </td> </tr> <tr> <td> Oligoarticular </td> <td> 15 </td> <td> 8.5 (3–17.9) </td> <td> 2.4 (0.3–14) </td> <td> 1.3 (1–3)/1.5 (1–3) </td> <td> 6.3 (5–10) </td> <td> 26.5 (7–90) </td> <td> NSAID alone; 11 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> NSAID, MTX; 2 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> Nil; 2 </td> </tr> </tbody> </table> </body> </html>
train
306,751
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<html> <head> <meta charset="utf-8"/> <style> table, th, td { border: 1px solid black; font-size: 10px; } </style> </head> <body> <table frame="hsides" rules="groups" width="100%"> <thead> <tr> <td> <b> Course </b> </td> <td> <b> No. of patients </b> </td> <td> <b> Age (years) </b> </td> <td> <b> Disease duration (years) </b> </td> <td> <b> No. of joints with active/limited range of motion </b> </td> <td> <b> PGI </b> </td> <td> <b> ESR (mm/h) </b> </td> <td> <b> Treatment; <i> n </i> </b> </td> </tr> </thead> <tbody> <tr> <td> Polyarticular </td> <td> 12 </td> <td> 11.5 (4.3–14.3) </td> <td> 3.4 (0.5–1.2) </td> <td> 5.3 (1–13)/18.3 (1–22) </td> <td> 7.8 (5–10) </td> <td> 78 (24–137) </td> <td> NSAID, MTX; 8 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> NSAID, CS, MTX; 2 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> NSAID, CS; 1 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> NSAID alone; 1 </td> </tr> <tr> <td> Oligoarticular </td> <td> 16 </td> <td> 7.5 (2.1–15.9) </td> <td> 2.4 (0.3–14) </td> <td> 1.8 (1–4)/1.9 (1–4) </td> <td> 6.9 (5–10) </td> <td> 31.5 (5–65) </td> <td> NSAID alone; 11 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> NSAID, MTX; 2 </td> </tr> <tr> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> Nil; 3 </td> </tr> </tbody> </table> </body> </html>