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1.0alpha7.train.400
14195597
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[]
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1.0alpha7.train.401
25196729
[ { "id": "1.0alpha7.train.401.sent", "type": "sentence", "text": [ "The syntaxin-1a-Munc18 complex was further incubated with various quantities of tomosyn on the membranes for 2 hr. Syntaxin-1a bound to tomosyn was detected." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
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1.0alpha7.train.402
20172896
[ { "id": "1.0alpha7.train.402.sent", "type": "sentence", "text": [ "If the engrailed-2 gene were a direct target of Wnt signaling, which worked through β-catenin binding to LEF/TCF homologs on the promoter, then one would predict that induction of the engrailed-2 gene by Wnt and β-catenin could be blocked by a dominant negative TCF." ], "offsets": [ [ 0, 266 ] ] } ]
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[]
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1.0alpha7.train.403
1931877
[ { "id": "1.0alpha7.train.403.sent", "type": "sentence", "text": [ " Sp1, Sp3, and Sp4 bind to the GC box of the ODC promoter. " ], "offsets": [ [ 0, 64 ] ] } ]
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[]
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1.0alpha7.train.404
3584980
[ { "id": "1.0alpha7.train.404.sent", "type": "sentence", "text": [ " Based on the present study, we propose that Axam may form a complex with Axin constitutively in the absence of Wnt, thereby Dvl does not bind to Axin. " ], "offsets": [ [ 0, 158 ] ] } ]
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[]
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1.0alpha7.train.405
1845538
[ { "id": "1.0alpha7.train.405.sent", "type": "sentence", "text": [ " To further map the PR binding motif of RIZ proteins, truncation mutants of RIZ1 were generated by in vitro transcription and translation of various mutant constructs (Fig. 5 A). " ], "offsets": [ [ 0, 190 ] ] } ]
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[]
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1.0alpha7.train.406
23330418
[ { "id": "1.0alpha7.train.406.sent", "type": "sentence", "text": [ "First, we tested whether anti-L1 Fab remains bound to L1 in endosomal compartments whose pH is slightly acidic: pH 6.0-6.5 in early endosomes and pH 5.0-6.0 in late endosomes (Nixon and Cataldo, 1995)." ], "offsets": [ [ 0, 201 ] ] } ]
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[]
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[]
1.0alpha7.train.407
15411318
[ { "id": "1.0alpha7.train.407.sent", "type": "sentence", "text": [ " In NBS cells, neither Nbs1p70 nor Mre11 bound to E2F sites, whereas E2F1 binding was unaffected (Fig. 3C). " ], "offsets": [ [ 0, 114 ] ] } ]
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1.0alpha7.train.408
20250431
[ { "id": "1.0alpha7.train.408.sent", "type": "sentence", "text": [ "dCtBP also binds to Hairy and a number of transcriptional repressors." ], "offsets": [ [ 0, 71 ] ] } ]
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1.0alpha7.train.409
11989537
[ { "id": "1.0alpha7.train.409.sent", "type": "sentence", "text": [ " PIP2 also binds to vinculin, which then interacts with talin. " ], "offsets": [ [ 0, 66 ] ] } ]
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1.0alpha7.train.410
20472368
[ { "id": "1.0alpha7.train.410.sent", "type": "sentence", "text": [ "Concurrent binding of Sp1 and AP2 to the hTAFII55 promoter-proximal region The extended footprints exhibited by individual Sp1 and AP2 proteins raise an interesting possibility that both proteins may bind simultaneously to the hTAFII55 promoter." ], "offsets": [ [ 0, 253 ] ] } ]
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[]
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1.0alpha7.train.411
9621758
[ { "id": "1.0alpha7.train.411.sent", "type": "sentence", "text": [ " Spectrin, which binds to F-actin beneath plasma membrane and forms a membrane cortical meshwork, also accumulates at the leading edges of motile cells (Burridge et al., 1982 ; Sormunen and Lehto, 1995 ). " ], "offsets": [ [ 0, 211 ] ] } ]
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1.0alpha7.train.412
762988
[ { "id": "1.0alpha7.train.412.sent", "type": "sentence", "text": [ " Although the residual activity was close to background, TPA may still be bound to PKC and thereby maintain phosphorylation and activation of the substrate. " ], "offsets": [ [ 0, 160 ] ] } ]
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[]
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1.0alpha7.train.413
553419
[ { "id": "1.0alpha7.train.413.sent", "type": "sentence", "text": [ "Paxillin failed to bind to GST alone or to the SH2 domain of Grb2." ], "offsets": [ [ 0, 70 ] ] } ]
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1.0alpha7.train.414
11787497
[ { "id": "1.0alpha7.train.414.sent", "type": "sentence", "text": [ " While the region of Apaf-1 that is involved in binding with Hsp90 is not known, our results demonstrate that Hsp90 binds to Apaf-1 at a different site than that of cyt c (data not shown). " ], "offsets": [ [ 0, 195 ] ] } ]
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1.0alpha7.train.415
9615473
[ { "id": "1.0alpha7.train.415.sent", "type": "sentence", "text": [ " Since direct binding of PAK to paxillin was not observed, the precipitation of PAK by paxillin LD4 from cell and tissue lysates likely occurs as a result of its association with PIX (Fig. 7; Bagrodia et al., 1998 ; Manser et al., 1998 ). " ], "offsets": [ [ 0, 249 ] ] } ]
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[]
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1.0alpha7.train.416
2941175
[ { "id": "1.0alpha7.train.416.sent", "type": "sentence", "text": [ "Munc18a is at once essential and inhibitory to secretion (8) because while Sec1p and its homologues are necessary for membrane trafficking and the final stages of protein secretion (9, 10), high affinity binding between Munc18a and syntaxin 1a also inhibits the association of vesicle SNAREs with syntaxin 1a (5-7, 11)." ], "offsets": [ [ 0, 319 ] ] } ]
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[]
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1.0alpha7.train.417
3470292
[ { "id": "1.0alpha7.train.417.sent", "type": "sentence", "text": [ " A program of study focused on identifying these binding site(s) ( 5, 6, 46, 47) culminated in the discovery that synaptotagmin I bound AP-2 with high affinity in vitro ( 7). " ], "offsets": [ [ 0, 182 ] ] } ]
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[]
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1.0alpha7.train.418
2068064
[ { "id": "1.0alpha7.train.418.sent", "type": "sentence", "text": [ " The percent tsf mutant coat protein bound to GroEL, however, does show a dependence upon GroEL/S concentration. " ], "offsets": [ [ 0, 117 ] ] } ]
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[]
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1.0alpha7.train.419
18178818
[ { "id": "1.0alpha7.train.419.sent", "type": "sentence", "text": [ " This was not because of reduced binding of cyclin A to the Cdk2, because cyclin A strongly activated the histone H1 kinase activity of the Texas Red-labeled GST-Cdk2 preparation (data not shown). " ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.420
2986894
[ { "id": "1.0alpha7.train.420.sent", "type": "sentence", "text": [ " Further, adaptor proteins such as FE65, whose protein interaction domains bind the cytoplasmic portions of both LRP and APP ( 37), may also be involved in linking these two molecules. " ], "offsets": [ [ 0, 191 ] ] } ]
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[]
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1.0alpha7.train.421
15771301
[ { "id": "1.0alpha7.train.421.sent", "type": "sentence", "text": [ " Lanes 16 and 17 are a longer autoradiographic exposure of lanes 14 and 15, to more clearly demonstrate the previously reported observation that MEIS1 binds to HOXA9 in the absence of PBX proteins ( 41). " ], "offsets": [ [ 0, 209 ] ] } ]
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[]
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1.0alpha7.train.422
20260622
[ { "id": "1.0alpha7.train.422.sent", "type": "sentence", "text": [ " Confirming the two-hybrid data, DCAP binds to Axin ( Fig. 3, right panel). " ], "offsets": [ [ 0, 80 ] ] } ]
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[]
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1.0alpha7.train.423
22807496
[ { "id": "1.0alpha7.train.423.sent", "type": "sentence", "text": [ " The model suggests that Ral is bound to PLD but cannot directly activate the enzyme; therefore other molecules, such as Arf, Rac, or Rho are necessary for a fully activated signaling complex. " ], "offsets": [ [ 0, 199 ] ] } ]
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[]
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1.0alpha7.train.424
12711193
[ { "id": "1.0alpha7.train.424.sent", "type": "sentence", "text": [ " Regulation of 3' splice site choice, both positive and negative, can be realized by influencing the pyrimidine tract binding of U2AF (Tian and Maniatis 1993 ; Valcarcel et al. 1993 ; Reed 1996 ). " ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.425
24577808
[ { "id": "1.0alpha7.train.425.sent", "type": "sentence", "text": [ " In this light, it is interesting that the wild-type GSK3 strongly stimulated the binding of Axin to LRP-5, whereas a kinase-dead GSK3 did not. " ], "offsets": [ [ 0, 149 ] ] } ]
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[]
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1.0alpha7.train.426
12486893
[ { "id": "1.0alpha7.train.426.sent", "type": "sentence", "text": [ "ASF/SF2 binds a purine-rich element positioned within the 3'UTR of the mature PKCI-r mRNA." ], "offsets": [ [ 0, 94 ] ] } ]
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[]
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1.0alpha7.train.427
11846855
[ { "id": "1.0alpha7.train.427.sent", "type": "sentence", "text": [ " To investigate whether the K12 and K23 double mutations in eIF2beta reduced binding between eIF2 and eIF5 in vitro, we conducted pull-down assays with GST-eIF5 and wild-type or mutant eIF2 present in WCEs. " ], "offsets": [ [ 0, 216 ] ] } ]
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[]
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1.0alpha7.train.428
6744203
[ { "id": "1.0alpha7.train.428.sent", "type": "sentence", "text": [ " As shown in Fig. 3 E, when 8-azido-[gamma-32] GTP was covalently bound to Rad, addition of nm23 caused reduction in amount of [gamma-32] labeling on Rad, indicating that GTP was being hydrolyzed in situ. " ], "offsets": [ [ 0, 212 ] ] } ]
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[]
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1.0alpha7.train.429
11231991
[ { "id": "1.0alpha7.train.429.sent", "type": "sentence", "text": [ "This is in agreement with those reported by Seong et al. (1997) in the mapping of antigenic determinants for Bor56 in which it was found that human IgM antibody predominantly bound to AD I and AD III regions." ], "offsets": [ [ 0, 211 ] ] } ]
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[]
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1.0alpha7.train.430
4638492
[ { "id": "1.0alpha7.train.430.sent", "type": "sentence", "text": [ "A18 hnRNP Binds Specifically to RPA2 and Thioredoxin 3′-UTRs" ], "offsets": [ [ 0, 60 ] ] } ]
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[]
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1.0alpha7.train.431
4638492
[ { "id": "1.0alpha7.train.431.sent", "type": "sentence", "text": [ "Our immunotube technique revealed that A18 hnRNP binds to a large number of stress-responsive transcripts (Table I)." ], "offsets": [ [ 0, 116 ] ] } ]
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[]
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[]
1.0alpha7.train.432
9849120
[ { "id": "1.0alpha7.train.432.sent", "type": "sentence", "text": [ "As shown in Fig. 3 B, lane 2, phosphorylated p97 bound to p47." ], "offsets": [ [ 0, 62 ] ] } ]
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[]
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1.0alpha7.train.433
1550912
[ { "id": "1.0alpha7.train.433.sent", "type": "sentence", "text": [ " In this experiment, any binding of heparin to Abeta should have been revealed as a series of electrophoretic bands whose mobility was progressively increased by increasing heparin concentrations. " ], "offsets": [ [ 0, 201 ] ] } ]
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[]
1.0alpha7.train.434
15814807
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1.0alpha7.train.435
1630826
[ { "id": "1.0alpha7.train.435.sent", "type": "sentence", "text": [ "The basic properties of the side chain of lysine 13, together with the observation that ATP protected this residue against modification by pyridoxal phosphate, not only argues for an active-site location for this lysine but also prompts speculation that lysine 13 could stabilize ATP binding because of interaction between the positively charged ϵ-amino group and the negatively charged phosphoryl groups of ATP." ], "offsets": [ [ 0, 412 ] ] } ]
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[]
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[]
1.0alpha7.train.436
7266947
[ { "id": "1.0alpha7.train.436.sent", "type": "sentence", "text": [ " This latter hypothesis would be in agreement with the fact that overexpression of GTP-bound forms of rab proteins generally results in a gain of function ( 2, 3). " ], "offsets": [ [ 0, 168 ] ] } ]
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[]
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1.0alpha7.train.437
16448553
[ { "id": "1.0alpha7.train.437.sent", "type": "sentence", "text": [ "Dynamin 2, a binding partner of the SH3 domain of amphiphysin (9), was recruited to the tubules when coexpressed with M-amphiphysin 2 (Fig. 2D), but not when coexpressed with its BAR* domain, which was sufficient to induce tubulation (Fig. 2, B and E)." ], "offsets": [ [ 0, 252 ] ] } ]
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1.0alpha7.train.438
24683820
[ { "id": "1.0alpha7.train.438.sent", "type": "sentence", "text": [ "Next we compared the binding of PR and NF1 to the MMTV promoter presented either as free DNA or in minichromosomes." ], "offsets": [ [ 0, 118 ] ] } ]
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[]
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1.0alpha7.train.439
12893112
[ { "id": "1.0alpha7.train.439.sent", "type": "sentence", "text": [ "Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis." ], "offsets": [ [ 0, 122 ] ] } ]
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[]
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1.0alpha7.train.440
1262529
[ { "id": "1.0alpha7.train.440.sent", "type": "sentence", "text": [ "p100 bound directly to the SH2 domains of both SHP-2 and the p85 subunit of phosphatidylinositol 3-kinase." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.441
25205144
[ { "id": "1.0alpha7.train.441.sent", "type": "sentence", "text": [ "To further test whether CDI results from an action of endogenous calmodulin, whole-cell NMDA receptor-mediated currents were recorded following the infusion of a calmodulin binding peptide (CBP) into NR1/NR2A-expressing HEK 293 cells to reduce intracellular free calmodulin." ], "offsets": [ [ 0, 274 ] ] } ]
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[]
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1.0alpha7.train.442
1352390
[ { "id": "1.0alpha7.train.442.sent", "type": "sentence", "text": [ "This phosphorylation is crucial for Shc binding to Grb2 and MT-induced transformation." ], "offsets": [ [ 0, 89 ] ] } ]
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1.0alpha7.train.443
5927999
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1.0alpha7.train.444
3472848
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[]
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1.0alpha7.train.445
22779231
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[]
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1.0alpha7.train.446
9712292
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[]
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1.0alpha7.train.447
9850644
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[]
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1.0alpha7.train.448
9509122
[ { "id": "1.0alpha7.train.448.sent", "type": "sentence", "text": [ " (C, c) Binding of 125I-Tiam1 fragment to the spectrin binding domain of ankyrin. " ], "offsets": [ [ 0, 85 ] ] } ]
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[]
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1.0alpha7.train.449
16288445
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[]
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1.0alpha7.train.450
13942918
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[]
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1.0alpha7.train.451
25196685
[ { "id": "1.0alpha7.train.451.sent", "type": "sentence", "text": [ "We confirmed using a blot overlay assay that tomosyn directly bound to syntaxin-1a." ], "offsets": [ [ 0, 85 ] ] } ]
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[]
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1.0alpha7.train.452
2077598
[ { "id": "1.0alpha7.train.452.sent", "type": "sentence", "text": [ " Finally, DM stabilizes class II peptide binding sites against inactivation ( 25, 26). " ], "offsets": [ [ 0, 91 ] ] } ]
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[]
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[]
1.0alpha7.train.453
899352
[ { "id": "1.0alpha7.train.453.sent", "type": "sentence", "text": [ "In addition, it was reported that a soluble form of CNTFRα (lacking the glycosylphosphatidylinositol linkage) can bind CNTF and activate gp130-LIFRβ-bearing cells (Taga et al., 1992; Davis et al., 1993b; Robledo et al., 1996)." ], "offsets": [ [ 0, 226 ] ] } ]
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[]
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1.0alpha7.train.454
18858557
[ { "id": "1.0alpha7.train.454.sent", "type": "sentence", "text": [ " Therefore, projectin might not bind CaMKII to serve as its substrate. " ], "offsets": [ [ 0, 74 ] ] } ]
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[]
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1.0alpha7.train.455
9737637
[ { "id": "1.0alpha7.train.455.sent", "type": "sentence", "text": [ "It is not clear at present whether the binding of ERM proteins to CD43 and ICAM-2 (and to as yet unidentified ERM membrane-binding partners) in vivo is also regulated by the Rho signaling pathway." ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.456
5539444
[ { "id": "1.0alpha7.train.456.sent", "type": "sentence", "text": [ "Oxidative stress stimulates binding of Sp1 and Sp3 to the VEGF-A promoter." ], "offsets": [ [ 0, 78 ] ] } ]
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[]
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1.0alpha7.train.457
15373513
[ { "id": "1.0alpha7.train.457.sent", "type": "sentence", "text": [ "This argues for a function of U2AF35 in addition to assisting U2AF65 binding." ], "offsets": [ [ 0, 79 ] ] } ]
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[]
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[]
1.0alpha7.train.458
25325723
[ { "id": "1.0alpha7.train.458.sent", "type": "sentence", "text": [ " All the fusion proteins that bound to calmodulin contained the N-terminal 32 residues, while those proteins that lacked these residues failed to associate with calmodulin (Figure 2A) . " ], "offsets": [ [ 0, 192 ] ] } ]
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[]
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[]
1.0alpha7.train.459
8963181
[ { "id": "1.0alpha7.train.459.sent", "type": "sentence", "text": [ "These observations support a mechanism in which GBP binding to Xgsk-3 prevents substrate phosphorylation." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.460
15941453
[ { "id": "1.0alpha7.train.460.sent", "type": "sentence", "text": [ " ( Rho-associated coiled-coil-containing protein kinase) are activated by the GTP-bound form of Rho ( 31, 42, 50). " ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "1.0alpha7.train.460.ent0_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.460.ent1_0", "type": "protein", "text": [ "Rho-associated coiled-coil-containing protein kinase" ], "offsets": [ [ 3, 55 ] ], "normalized": [] }, { "id": "1.0alpha7.train.460.ent2_0", "type": "protein", "text": [ "GTP-bound form of Rho" ], "offsets": [ [ 79, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.460.ent3_0", "type": "protein-family", "text": [ "Rho" ], "offsets": [ [ 3, 6 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004665" } ] }, { "id": "1.0alpha7.train.460.ent4_1", "type": "protein-family", "text": [ "Rho" ], "offsets": [ [ 98, 101 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004665" } ] } ]
[]
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1.0alpha7.train.461
3392894
[ { "id": "1.0alpha7.train.461.sent", "type": "sentence", "text": [ " Here we report that p202a binds c-Myc in vitro and in vivo, thereby inhibiting the binding of c-Myc to Max, as well as the transcriptional activity of c-Myc. " ], "offsets": [ [ 0, 167 ] ] } ]
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1.0alpha7.train.462
23330713
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1.0alpha7.train.463
1631394
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[]
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1.0alpha7.train.464
1876014
[ { "id": "1.0alpha7.train.464.sent", "type": "sentence", "text": [ "These proteins are responsible for cadherin binding to the actin cytoskeleton and possibly for intracellular signaling ( 39)." ], "offsets": [ [ 0, 127 ] ] } ]
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[]
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1.0alpha7.train.465
12543870
[ { "id": "1.0alpha7.train.465.sent", "type": "sentence", "text": [ "Mad2 binds and inhibits Cdc20 in vitro (Fang et al. 1998a ; Hwang et al. 1998 ; Kallio et al. 1998 Kim ; et al. 1998 )." ], "offsets": [ [ 0, 125 ] ] } ]
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1.0alpha7.train.466
24889319
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[]
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1.0alpha7.train.467
19847791
[ { "id": "1.0alpha7.train.467.sent", "type": "sentence", "text": [ " ( C) This PIC binds the Ad origin of DNA replication (the 5' attached TP was omitted for simplification), most likely in a irregular, bent DNA structure. " ], "offsets": [ [ 0, 158 ] ] } ]
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[]
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1.0alpha7.train.468
9631609
[ { "id": "1.0alpha7.train.468.sent", "type": "sentence", "text": [ "Indeed, recent data indicates that Bcl-xL can bind to the mammalian CED-4 homologue Apaf-1, at least under some conditions (Hu et al., 1998; Pan et al., 1998)." ], "offsets": [ [ 0, 159 ] ] } ]
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1.0alpha7.train.469
4110078
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[]
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1.0alpha7.train.470
19227767
[ { "id": "1.0alpha7.train.470.sent", "type": "sentence", "text": [ "The initial steps in formation of the pre-initiation complex - binding of TFIID and TFIIA - are likely to be important determinants of this dynamic equilibrium." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "1.0alpha7.train.470.ent0_0", "type": "protein-complex", "text": [ "pre-initiation complex" ], "offsets": [ [ 38, 60 ] ], "normalized": [] }, { "id": "1.0alpha7.train.470.ent1_0", "type": "protein", "text": [ "TFIIA" ], "offsets": [ [ 84, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2957" }, { "db_name": "hgnc", "db_id": "GTF2A1" }, { "db_name": "uniprot", "db_id": "P52655" } ] }, { "id": "1.0alpha7.train.470.ent2_0", "type": "protein-complex", "text": [ "TFIID" ], "offsets": [ [ 74, 79 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.471
6933611
[ { "id": "1.0alpha7.train.471.sent", "type": "sentence", "text": [ " Although SREBPs are capable of binding E-boxes with high affinity in vitro ( 26, 30), sterol regulation of all carefully examined promoters so far is mediated through SREBP binding to SRE elements and not E-boxes ( 4, 6-10, 27-30). " ], "offsets": [ [ 0, 241 ] ] } ]
[ { "id": "1.0alpha7.train.471.ent0_0", "type": "DNA", "text": [ "SRE elements" ], "offsets": [ [ 190, 202 ] ], "normalized": [] }, { "id": "1.0alpha7.train.471.ent1_0", "type": "DNA", "text": [ "E-boxes" ], "offsets": [ [ 41, 48 ] ], "normalized": [] }, { "id": "1.0alpha7.train.471.ent2_1", "type": "DNA", "text": [ "E-boxes" ], "offsets": [ [ 211, 218 ] ], "normalized": [] }, { "id": "1.0alpha7.train.471.ent3_0", "type": "protein", "text": [ "SREBP" ], "offsets": [ [ 172, 177 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6720" }, { "db_name": "hgnc", "db_id": "SREBF1" }, { "db_name": "uniprot", "db_id": "P36956" } ] } ]
[]
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1.0alpha7.train.472
22630949
[ { "id": "1.0alpha7.train.472.sent", "type": "sentence", "text": [ " At low pH does DM bind to the closed form of MHCII, prying it open, or does DM simply bind to and stabilize the open form of MHCII induced spontaneously by the shift to low pH? " ], "offsets": [ [ 0, 185 ] ] } ]
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[]
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1.0alpha7.train.473
20761608
[ { "id": "1.0alpha7.train.473.sent", "type": "sentence", "text": [ "Although VEGF binds both VEGFR-1 and VEGFR-2, only binding to VEGFR-2 generates mitogenic signal in ECs." ], "offsets": [ [ 0, 104 ] ] } ]
[ { "id": "1.0alpha7.train.473.ent0_0", "type": "cell", "text": [ "ECs" ], "offsets": [ [ 100, 103 ] ], "normalized": [] }, { "id": "1.0alpha7.train.473.ent1_0", "type": "protein", "text": [ "VEGFR-2" ], "offsets": [ [ 37, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3791" }, { "db_name": "hgnc", "db_id": "KDR" }, { "db_name": "uniprot", "db_id": "P35968" } ] }, { "id": "1.0alpha7.train.473.ent2_1", "type": "protein", "text": [ "VEGFR-2" ], "offsets": [ [ 62, 69 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3791" }, { "db_name": "hgnc", "db_id": "KDR" }, { "db_name": "uniprot", "db_id": "P35968" } ] }, { "id": "1.0alpha7.train.473.ent3_0", "type": "protein-family", "text": [ "VEGF" ], "offsets": [ [ 9, 13 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR036841" } ] }, { "id": "1.0alpha7.train.473.ent4_0", "type": "protein", "text": [ "VEGFR-1" ], "offsets": [ [ 25, 32 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2321" }, { "db_name": "hgnc", "db_id": "FLT1" }, { "db_name": "uniprot", "db_id": "P17948" } ] } ]
[]
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1.0alpha7.train.474
2616163
[ { "id": "1.0alpha7.train.474.sent", "type": "sentence", "text": [ " Thus, binding of USF to the DOR promoter sequence is more critical than that of Sp1/Sp3 in NS20Y cells. " ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "1.0alpha7.train.474.ent0_0", "type": "protein-family", "text": [ "USF" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024097" } ] }, { "id": "1.0alpha7.train.474.ent1_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 84, 87 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.474.ent2_0", "type": "protein", "text": [ "Sp3" ], "offsets": [ [ 88, 91 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6670" }, { "db_name": "hgnc", "db_id": "SP3" }, { "db_name": "uniprot", "db_id": "Q02447" } ] }, { "id": "1.0alpha7.train.474.ent3_0", "type": "cell", "text": [ "NS20Y" ], "offsets": [ [ 96, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.474.ent4_0", "type": "DNA", "text": [ "DOR promoter" ], "offsets": [ [ 31, 43 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.475
23310905
[ { "id": "1.0alpha7.train.475.sent", "type": "sentence", "text": [ "In addition to our finding that CYC is present in at least a 200-fold molar excess relative to dCLK in head extracts (see Fig. 4), this contention is supported further by the observations that (1) at all times in a daily cycle essentially all of the dCLK is stably bound to CYC (see Fig. 5A), and (2) the temporal abundance profile of dCLK in immune complexes recovered with anti-CYC antibodies is very similar to that of dCLK present in head extracts (see Fig.3C,D)." ], "offsets": [ [ 0, 467 ] ] } ]
[ { "id": "1.0alpha7.train.475.ent0_0", "type": "protein", "text": [ "CYC" ], "offsets": [ [ 32, 35 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O61734" } ] }, { "id": "1.0alpha7.train.475.ent1_1", "type": "protein", "text": [ "CYC" ], "offsets": [ [ 274, 277 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O61734" } ] }, { "id": "1.0alpha7.train.475.ent2_2", "type": "protein", "text": [ "CYC" ], "offsets": [ [ 380, 383 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O61734" } ] }, { "id": "1.0alpha7.train.475.ent3_0", "type": "protein", "text": [ "dCLK" ], "offsets": [ [ 95, 99 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O61735" } ] }, { "id": "1.0alpha7.train.475.ent4_1", "type": "protein", "text": [ "dCLK" ], "offsets": [ [ 250, 254 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O61735" } ] }, { "id": "1.0alpha7.train.475.ent5_2", "type": "protein", "text": [ "dCLK" ], "offsets": [ [ 335, 339 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O61735" } ] }, { "id": "1.0alpha7.train.475.ent6_3", "type": "protein", "text": [ "dCLK" ], "offsets": [ [ 422, 426 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O61735" } ] }, { "id": "1.0alpha7.train.475.ent7_0", "type": "reagent", "text": [ "anti-CYC antibodies" ], "offsets": [ [ 375, 394 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.476
15771353
[ { "id": "1.0alpha7.train.476.sent", "type": "sentence", "text": [ " Since our data suggested that MEIS1 was bound to either HOXA9 and/or PBX1a in the presence of DNA, we wished to study the interactions between these molecules in the absence of a DNA target. " ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "1.0alpha7.train.476.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 98, 101 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.476.ent1_1", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 183, 186 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.476.ent2_0", "type": "protein", "text": [ "HOXA9" ], "offsets": [ [ 59, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3205" }, { "db_name": "hgnc", "db_id": "HOXA9" }, { "db_name": "uniprot", "db_id": "P31269" } ] }, { "id": "1.0alpha7.train.476.ent3_0", "type": "protein", "text": [ "MEIS1" ], "offsets": [ [ 32, 37 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4211" }, { "db_name": "hgnc", "db_id": "MEIS1" }, { "db_name": "uniprot", "db_id": "U3KPR8" } ] }, { "id": "1.0alpha7.train.476.ent4_0", "type": "protein", "text": [ "PBX1a" ], "offsets": [ [ 73, 78 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5087" }, { "db_name": "hgnc", "db_id": "PBX1" }, { "db_name": "uniprot", "db_id": "P40424" } ] } ]
[]
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1.0alpha7.train.477
5872668
[ { "id": "1.0alpha7.train.477.sent", "type": "sentence", "text": [ " As described by Kumar et al. ( 17), the crystal structure of CtBP bound to NAD+ supports the prediction that CtBP is structurally similar to 3-phosphoglycerate dehydrogenase. " ], "offsets": [ [ 0, 186 ] ] } ]
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[]
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1.0alpha7.train.478
2277874
[ { "id": "1.0alpha7.train.478.sent", "type": "sentence", "text": [ "The fact that deletion of domain 7 did not affect the inhibition of osteoclastogenesis (Fig. 2 A) but significantly decreased the binding of OCIF to heparin (Fig. 3) indicates that binding ability of OCIF to heparin does not correlate with its osteoclastogenesis inhibitory activity in vitro." ], "offsets": [ [ 0, 292 ] ] } ]
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[]
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1.0alpha7.train.479
864775
[ { "id": "1.0alpha7.train.479.sent", "type": "sentence", "text": [ " Since a peptide encompassing this region binds to collagen type I and inhibits APP-collagen type I binding in nanomolar concentrations, this region may comprise the major part of the collagen type I binding site of APP. " ], "offsets": [ [ 0, 229 ] ] } ]
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[]
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1.0alpha7.train.480
15406437
[ { "id": "1.0alpha7.train.480.sent", "type": "sentence", "text": [ " Figure 5C shows that the binding of Rpb1 (the large subunit of RNA pol II) to both the GAL1 and GAL10 promoters increases with time after induction with galactose, reaching its maximum level at 60 min. " ], "offsets": [ [ 0, 212 ] ] } ]
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[]
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1.0alpha7.train.481
1986039
[ { "id": "1.0alpha7.train.481.sent", "type": "sentence", "text": [ "Binding of purified alpha-actinin to the beta1 cytoplasmic domain is shown in Fig. 1 B." ], "offsets": [ [ 0, 90 ] ] } ]
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[]
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1.0alpha7.train.482
11069909
[ { "id": "1.0alpha7.train.482.sent", "type": "sentence", "text": [ "On binding of LPS to TLRs, specifically TLR2 and TLR4, via CD14, a number of molecules are recruited to the receptor to mediate NF-κB activation, which include the adaptor molecule MyD88, the protein kinase IRAK, and the adaptor molecule TRAF-6, thus forming the receptor complex [29], resulting in interaction of downstream molecules and the subsequent activation of NF-κB." ], "offsets": [ [ 0, 374 ] ] } ]
[ { "id": "1.0alpha7.train.482.ent0_0", "type": "protein", "text": [ "IRAK" ], "offsets": [ [ 207, 211 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3654" }, { "db_name": "hgnc", "db_id": "IRAK1" }, { "db_name": "uniprot", "db_id": "P51617" } ] }, { "id": "1.0alpha7.train.482.ent1_0", "type": "protein-complex", "text": [ "NF-κB" ], "offsets": [ [ 128, 133 ] ], "normalized": [] }, { "id": "1.0alpha7.train.482.ent2_1", "type": "protein-complex", "text": [ "NF-κB" ], "offsets": [ [ 368, 373 ] ], "normalized": [] }, { "id": "1.0alpha7.train.482.ent3_0", "type": "chemical", "text": [ "LPS" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "53481794" } ] }, { "id": "1.0alpha7.train.482.ent4_0", "type": "protein-family", "text": [ "TLRs" ], "offsets": [ [ 21, 25 ] ], "normalized": [] }, { "id": "1.0alpha7.train.482.ent5_0", "type": "protein", "text": [ "CD14" ], "offsets": [ [ 59, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "929" }, { "db_name": "hgnc", "db_id": "CD14" }, { "db_name": "uniprot", "db_id": "P08571" } ] }, { "id": "1.0alpha7.train.482.ent6_0", "type": "protein", "text": [ "TRAF-6" ], "offsets": [ [ 238, 244 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7189" }, { "db_name": "hgnc", "db_id": "TRAF6" }, { "db_name": "uniprot", "db_id": "Q9Y4K3" } ] }, { "id": "1.0alpha7.train.482.ent7_0", "type": "protein", "text": [ "MyD88" ], "offsets": [ [ 181, 186 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4615" }, { "db_name": "hgnc", "db_id": "MYD88" }, { "db_name": "uniprot", "db_id": "Q99836" } ] } ]
[]
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1.0alpha7.train.483
4311853
[ { "id": "1.0alpha7.train.483.sent", "type": "sentence", "text": [ " Interestingly, TDP-43 can bind a minimum number of six UG (or TG) single-stranded dinucleotide stretches, and binding affinity increases with the number of repeats. " ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "1.0alpha7.train.483.ent0_0", "type": "DNA", "text": [ "TG" ], "offsets": [ [ 65, 67 ] ], "normalized": [] }, { "id": "1.0alpha7.train.483.ent1_0", "type": "DNA", "text": [ "UG" ], "offsets": [ [ 58, 60 ] ], "normalized": [] }, { "id": "1.0alpha7.train.483.ent2_0", "type": "DNA", "text": [ "UG (or TG) single-stranded dinucleotide" ], "offsets": [ [ 58, 97 ] ], "normalized": [] }, { "id": "1.0alpha7.train.483.ent3_0", "type": "protein", "text": [ "TDP-43" ], "offsets": [ [ 17, 23 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "23435" }, { "db_name": "hgnc", "db_id": "TARDBP" }, { "db_name": "uniprot", "db_id": "Q13148" } ] } ]
[]
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1.0alpha7.train.484
8909102
[ { "id": "1.0alpha7.train.484.sent", "type": "sentence", "text": [ " An N-terminal proline-rich sequence (PXXP) binds to Nck (Bokoch et al., 1996 ; Galisteo et al., 1996 ); a CRIB ( Cdc42/ Rac interactive binding) motif binds to GTP-bound forms of Cdc42 and Rac (Manser et al., 1994 ; Burbelo et al., 1995 ); and a proline-rich motif is constitutively bound to Pix, a guanine nucleotide exchange factor specific to Rac and Cdc42 (Manser et al., 1998 ). " ], "offsets": [ [ 0, 417 ] ] } ]
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[]
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1.0alpha7.train.485
4879462
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[]
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1.0alpha7.train.486
640037
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[]
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1.0alpha7.train.487
3405495
[ { "id": "1.0alpha7.train.487.sent", "type": "sentence", "text": [ " ( A), Annexin V binding by FACS analysis (apoptotic cells as a %-age of control) ( B), and DNA cleavage (laddering) ( C). " ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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[]
1.0alpha7.train.488
8909808
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[]
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[]
1.0alpha7.train.489
3199964
[ { "id": "1.0alpha7.train.489.sent", "type": "sentence", "text": [ "We previously determined that the flanking A nucleotides of the AUUUA motifs in the TNFα ARE were essential for binding of TTP to the TNFα ARE (11)." ], "offsets": [ [ 0, 148 ] ] } ]
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[]
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1.0alpha7.train.490
4890087
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[]
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1.0alpha7.train.491
24668074
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1.0alpha7.train.492
3806869
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1.0alpha7.train.493
4825807
[ { "id": "1.0alpha7.train.493.sent", "type": "sentence", "text": [ "MEP50 binds a subset of the Sm proteins." ], "offsets": [ [ 0, 42 ] ] } ]
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1.0alpha7.train.494
9485931
[ { "id": "1.0alpha7.train.494.sent", "type": "sentence", "text": [ "We find that the fourth repeat is necessary for the F-actin binding activity of cortactin and that the NTA region binds directly to the Arp2/3 complex." ], "offsets": [ [ 0, 155 ] ] } ]
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1.0alpha7.train.495
1551561
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1.0alpha7.train.496
2063195
[ { "id": "1.0alpha7.train.496.sent", "type": "sentence", "text": [ " On the other hand, fascin inhibits actin binding of cultured cell TM, when caldesmon is absent. " ], "offsets": [ [ 0, 102 ] ] } ]
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1.0alpha7.train.497
3194889
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1.0alpha7.train.498
21460729
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[]
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1.0alpha7.train.499
54841
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[]
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