 Pre-dosing GSK457 for a week followed by a combination of GSK457 and the exendin-4 AlbudAb for 28 days resulted in a vehicle-subtracted weight loss of 30.8%, far exceeding the sum of the exendin-4 AlbudAb and GSK457 effects, p < 0.001 (Fig 4)
GSK457 (10% w/w) combined with the exendin-4 AlbudAb
placebo
vehicle-subtracted weight loss