Median Tmax was achieved 4 hours earlier when OROS® hydromorphone was administered under fed conditions compared with fasting conditions (12 vs. 16 hours; P = 0.0062).
Treatment B (OROS® hydromorphone 16 mg; fed conditions
Treatment A (OROS® hydromorphone 16 mg; fasting conditions) 
Median time to peak plasma concentration (Tmax)