 Following the administration of normobaric hyperoxia, the first co-primary endpoint mean volume change of pneumocephalus was 87.83 (SE: 3.31) ml in patients treated with 100% O2 and it was 71.29 (SE: 3.31) ml in patients in the control arm (ANCOVA; estimate: 16.54 ml; 95% confidence interval (CI): [-26.00–7.08]; p = 0.001; Table 3)
normobaric hyperoxia at FiO2 100% over an endotracheal tube for 3 hours (treatment arm)
room air 
Stroop test