When considering only extinction learning in a novel context (ABA condition), the TIA group was significantly impaired compared to PLAC [t(38) = 1.989 p = 0.027; TIA 24.00% ± 3.81; PLAC 15.00% ± 2.43], while there was no significant difference in AAA extinction learning between groups [t(38) = 0.673 p = 0.252; TIA 18.25% ± 2.93; PLAC 16.00% ± 1.59—all t-tests one-tailed]. (See Figure 2A)
tiapride (TIA)
placebo
activation during ABA and AAA extinction in bilateral dlPFC (BA 9) and OFC (BA 10), fusiform gyrus and temporal pole, right hippocampus and left lingual gyrus