text_1: A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE).
text_2: We report that activation of basophils by autoreactive IgE causes their homing to lymph nodes, promoting T helper type 2 (T(H)2) cell differentiation and enhancing the production of self-reactive antibodies that cause lupus-like nephritis in mice lacking the Src family protein tyrosine kinase Lyn (Lyn(-/-) mice).