text_1: RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
text_2: Hence, our data attributed a functional importance to the temporal development of Vγ5(+) γδ T cells during thymus medulla formation for αβ T cell tolerance induction and demonstrated a Rank-mediated reciprocal link between DETC and Aire(+) mTEC maturation.