text_1: Stiff substrates inhibit mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner.
text_2: Mechanistically, Src-driven ubiquitination of E-cadherin by Cbl-like ubiquitin ligase releases P120-catenin to facilitate transcriptional activity of β-catenin, which initiates and reinforces mesoderm differentiation.