text_1: PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice.
text_2: Because cGMP can broadly influence diverse ion-channels, kinases, and phosphodiesterases, pre- as well as post-synaptically, the precise identity of cGMP targets mediating spinal LTP, their mechanisms of action, and their locus in the spinal circuitry are still unclear.