text_1: PKG-la plays an essential role in expression of spinal long term potentiation in PGK-la knockout mice.
text_2: Because cGMP can broadly influence diverse ion-channels, kinases, and phosphodiesterases, pre- as well as post-synaptically, the precise identity of cGMP targets mediating spinal LTP, their mechanisms of action, and their locus in the spinal circuitry are still unclear.