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{
 "id": "1274df29-3d1a-41e4-935f-639f4f8729e4",
 "disease": {
  "id": "H00031",
  "names": [
   "Breast cancer"
  ],
  "dbLinks": {
   "icd10": [
    "C50"
   ],
   "mesh": [
    "D001943"
   ]
  },
  "category": "Cancer"
 },
 "article": {
  "id": "23890780",
  "text": "BACKGROUND:\nAssociations between circulating concentrations of oestrogens, progesterone, and androgens with breast cancer and related risk factors in premenopausal women are not well understood. We aimed to characterise these associations with a pooled analysis of data from seven studies.\n\nMETHODS:\nIndividual participant data for prediagnostic sex hormone and sex hormone-binding globulin (SHBG) concentrations were contributed from seven prospective studies. We restricted analyses to women who were premenopausal and younger than 50 years at blood collection, and to women with breast cancer diagnosed before age 50 years. We estimated odds ratios (ORs) with 95% CIs for breast cancer associated with hormone concentrations by conditional logistic regression in cases and controls matched for age, date of blood collection, and day of cycle, with stratification by study and further adjustment for cycle phase. We examined associations of hormones with risk factors for breast cancer in control women by comparing geometric mean hormone concentrations in categories of these risk factors, adjusted for study, age, phase of menstrual cycle, and body-mass index (BMI). All statistical tests were two-sided.\n\nFINDINGS:\nWe included data for up to 767 women with breast cancer and 1699 controls in the risk analyses. Breast cancer risk was associated with a doubling in concentrations of oestradiol (OR 1路19, 95% CI 1路06-1路35), calculated free oestradiol (1路17, 1路03-1路33), oestrone (1路27, 1路05-1路54), androstenedione (1路30, 1路10-1路55), dehydroepiandrosterone sulphate (1路17, 1路04-1路32), testosterone (1路18, 1路03-1路35), and calculated free testosterone (1路08, 0路97-1路21). Breast cancer risk was not associated with luteal phase progesterone (doubling in concentration OR 1路00, 95% CI 0路92-1路09), and adjustment for other factors had little effect on any of these ORs. Cross-sectional analyses in control women showed several associations of sex hormones with breast cancer risk factors.\n\nINTERPRETATION:\nCirculating oestrogens and androgens are positively associated with the risk for breast cancer in premenopausal women."
 },
 "questions": [
  {
   "id": "fe91b342-6c3b-4d09-8aa0-988495fa9c62",
   "text": "What are the risk factors of Breast Cancer?",
   "answers": [
    {
     "answer_start": 1357,
     "text": "doubling in concentrations of oestradiol"
    },
    {
     "answer_start": 1427,
     "text": "calculated free oestradiol"
    },
    {
     "answer_start": 1473,
     "text": "oestrone"
    },
    {
     "answer_start": 1500,
     "text": " androstenedione"
    },
    {
     "answer_start": 1536,
     "text": "dehydroepiandrosterone sulphate"
    },
    {
     "answer_start": 1587,
     "text": "testosterone"
    },
    {
     "answer_start": 2003,
     "text": "Circulating oestrogens and androgens"
    }
   ]
  }
 ]
}