|
{ |
|
"id": "07d8bf30-1ff4-463c-b4e7-09241fdfe69e", |
|
"disease": { |
|
"id": "H00056", |
|
"names": [ |
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"Alzheimer disease", |
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"Dementia due to Alzheimer disease" |
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], |
|
"dbLinks": { |
|
"icd10": [ |
|
"G30" |
|
], |
|
"mesh": [ |
|
"D000544" |
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] |
|
}, |
|
"category": "Neurodegenerative disease" |
|
}, |
|
"article": { |
|
"id": "8113792", |
|
"text": "Almost all patients \u003e 40 years of age with Down's syndrome (DS) develop the pathology characteristic of Alzheimer's disease: abundant beta-amyloid plaques and neurofibrillary tangles. We have investigated the gene expression of beta-amyloid protein precursor (APP) and tau in DS and age-matched control brains and found that levels of both mRNAs were significantly elevated in DS. Such up-regulation was not observed in two other neuronal proteins. A correlation between total APP and tau mRNA levels was also found in DS brain but distinct from the pattern observed in normal brain. Although a proportionality existed between APP-695 mRNA and three-repeat tau mRNA in DS, the proportionality between APP-751 mRNA and four-repeat tau mRNA, which is normally present, was not observed. Thus, DS brains are primarily characterized by the up-regulation of tau mRNA as well as APP mRNA and disruption of the coordinate expression between APP-751 and four-repeat tau." |
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}, |
|
"questions": [ |
|
{ |
|
"id": "5e05a017-96ba-4e63-8c92-85faa233dc56", |
|
"text": "What are the risk factors of Alzheimer disease?", |
|
"answers": [ |
|
{ |
|
"answer_start": 11, |
|
"text": "patients \u003e 40 years of age with Down's syndrome (DS)" |
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} |
|
] |
|
} |
|
] |
|
} |