{
 "id": "07d8bf30-1ff4-463c-b4e7-09241fdfe69e",
 "disease": {
  "id": "H00056",
  "names": [
   "Alzheimer disease",
   "Dementia due to Alzheimer disease"
  ],
  "dbLinks": {
   "icd10": [
    "G30"
   ],
   "mesh": [
    "D000544"
   ]
  },
  "category": "Neurodegenerative disease"
 },
 "article": {
  "id": "8113792",
  "text": "Almost all patients \u003e 40 years of age with Down's syndrome (DS) develop the pathology characteristic of Alzheimer's disease: abundant beta-amyloid plaques and neurofibrillary tangles. We have investigated the gene expression of beta-amyloid protein precursor (APP) and tau in DS and age-matched control brains and found that levels of both mRNAs were significantly elevated in DS. Such up-regulation was not observed in two other neuronal proteins. A correlation between total APP and tau mRNA levels was also found in DS brain but distinct from the pattern observed in normal brain. Although a proportionality existed between APP-695 mRNA and three-repeat tau mRNA in DS, the proportionality between APP-751 mRNA and four-repeat tau mRNA, which is normally present, was not observed. Thus, DS brains are primarily characterized by the up-regulation of tau mRNA as well as APP mRNA and disruption of the coordinate expression between APP-751 and four-repeat tau."
 },
 "questions": [
  {
   "id": "5e05a017-96ba-4e63-8c92-85faa233dc56",
   "text": "What are the risk factors of Alzheimer disease?",
   "answers": [
    {
     "answer_start": 11,
     "text": "patients \u003e 40 years of age with Down's syndrome (DS)"
    }
   ]
  }
 ]
}