H00004.json

{
 "id": "H00004",
 "disease": {
  "id": "H00004",
  "names": [
   "Chronic myeloid leukemia"
  ],
  "dbLinks": {
   "icd10": [
    "C92.1"
   ],
   "mesh": [
    "D015464"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
  {
   "text": "paternal grandfathers and grandmothers of people with achondroplasia",
   "score": 14.025308609008789,
   "articlesIDs": [
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  {
   "text": "metabolically unhealthy obesity",
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  {
   "text": "patients with chronic myeloproliferative neoplasms",
   "score": 13.94378662109375,
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    "22039256"
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  },
  {
   "text": "et, pv, and cml patients",
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  {
   "text": "metabolically unhealthy normal weight and metabolically unhealthy obesity",
   "score": 13.736063957214355,
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  {
   "text": "match for dpb1",
   "score": 13.688713073730469,
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  {
   "text": "recipient age \u003e or =40 years, urd-hct",
   "score": 13.573385238647461,
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  {
   "text": "previous proton pump inhibitor (ppi) medication",
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  {
   "text": "metabolic abnormalities",
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  {
   "text": "cd3 cell dose 50 x 10(6)/kg",
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  {
   "text": "patients with current diagnosis of leukemia",
   "score": 13.436667442321777,
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  },
  {
   "text": "individuals carrying cyp1a1 ile/val (ag) and gstm1 null genotype",
   "score": 13.312516212463379,
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  {
   "text": "cyp1a1 val allele",
   "score": 13.305952072143555,
   "articlesIDs": [
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  {
   "text": "smoking",
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  {
   "text": "sv40 dna virus",
   "score": 13.24594497680664,
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  {
   "text": "c677t and a1298c polymorphisms",
   "score": 13.21601676940918,
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  {
   "text": "gstt1 null genotype",
   "score": 13.188690185546875,
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  {
   "text": "preceding grade ii-iv acute gvhd, recipient age \u003e or =40 years, urd-hct",
   "score": 13.109143257141113,
   "articlesIDs": [
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  {
   "text": "grandparents of people with achondroplasia",
   "score": 13.091400146484375,
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   "text": "patients with mf",
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   "text": "breast cancer patients",
   "score": 13.020822525024414,
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   "text": "exposure to benzene at work",
   "score": 13.020140647888184,
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  {
   "text": "age ≥10 years at diagnosis",
   "score": 13.007652282714844,
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  {
   "text": "cyp3a5*3 allele",
   "score": 12.990463256835938,
   "articlesIDs": [
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  {
   "text": "previous diagnoses of dyspepsia, gastritis or peptic ulcers",
   "score": 12.978850364685059,
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  {
   "text": "asian-pacific islanders (api)",
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  {
   "text": "hla b46 and dr9 loci and the a2b46dr9 haplotype",
   "score": 12.920897483825684,
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  {
   "text": "absence of donor il10 ata/acc and presence of donor il1rn allele 2 genotypes",
   "score": 12.912663459777832,
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  {
   "text": "a match for dpb1",
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  {
   "text": "homozygous 3/3 genotype and cyp3a5*3 allele",
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  {
   "text": "cyp3a5*3 gene polymorphism",
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  {
   "text": "absence of patient tnfrsfib 196r, absence of donor il10 ata/acc",
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   "text": "allo-sct and age ≥10 years at diagnosis",
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   "text": "myelodysplastic syndrome, and cd3 cell dose 50 x 10(6)/kg",
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  {
   "text": "patients with anll/nhl",
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   "text": "asian-pacific islanders (api). hispanics",
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   "text": "current smokers",
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   "text": "adolescents treated for hodgkin's disease",
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   "text": "receiving stem cell transplantation",
   "score": 12.71450424194336,
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  {
   "text": "kras_rs61764370 snp",
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   "text": "low bmi (\u003c20)",
   "score": 12.673055648803711,
   "articlesIDs": [
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  {
   "text": "substitutions at position 116 of class i heavy chain",
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   "articlesIDs": [
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  {
   "text": "hsct for chronic myeloid leukemia, the hla b46 and dr9 loci",
   "score": 12.629600524902344,
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   "text": "occupational exposure to benzene",
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  {
   "text": "african-americans",
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   "text": "crf",
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   "text": "aged ≥ 60",
   "score": 12.563405990600586,
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  {
   "text": "xpc 939gln/gln genotype",
   "score": 12.53678035736084,
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  {
   "text": "kir-hla compound profiles id2",
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  {
   "text": "being male (ahr 13.49, p = 0.012), receiving stem cell transplantation",
   "score": 12.530189514160156,
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  {
   "text": "polycythemia vera (pv) and essential thrombocythemia (et)",
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   "text": "localized bc",
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   "text": "any alcohol drinking",
   "score": 12.485740661621094,
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   "text": "hepatitis b virus",
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   "text": "hla compound profiles id2 (kir aa1-hla-c1/c1-bw6/bw6-a3/11)",
   "score": 12.45248031616211,
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   "text": "minor homozygote genotype of the kras_rs61764370 polymorphism",
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   "text": "aged ≥ 60 (ahr 3.24, p = 0.022), being male",
   "score": 12.44722843170166,
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   "text": "hla antigens cw7, dr5, dr6",
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   "text": "subjects carrying the xpc 939gln/gln genotype",
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  {
   "text": "patients with et, 1.4 (95% ci: 1.3-1.5) for patients with pv",
   "score": 12.347847938537598,
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   "text": "gstt1 null genotype frequency",
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   "text": "apis",
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   "text": "1236 tt in exon 12",
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   "text": "interferon-α therapy",
   "score": 12.268444061279297,
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   "text": "female compared with male donor transplantation",
   "score": 12.246185302734375,
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   "text": "patients diagnosed with ulcerative colitis (uc)",
   "score": 12.243982315063477,
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   "text": "exposure to dark hair dye",
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   "text": "allogeneic stem cell transplantation (allo-sct)",
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   "text": "homozygosity for dr53",
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   "text": "benzene-exposed workers",
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   "text": "peptic ulcers, as well as previous proton pump inhibitor (ppi) medication",
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   "text": "the diagnosis of chronic myeloid leukemia (cml) or myelodysplastic syndrome",
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   "text": "high doses of bcr-abl tkis",
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   "text": "substitutions at positions 116 and 114 of class i heavy chain",
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   "text": "patients with chronic myeloid leukemia (cml) for ps0rs1c1-rs2285803",
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   "text": "bc diagnosis",
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   "text": "non-hla genotypes",
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   "text": "dpb1 was matched",
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   "text": "multiple myeloma (mm) patients",
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   "text": "adolescent females treated for recurrent hodgkin's disease",
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   "text": "patients with end-stage renal disease (esrd)",
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   "text": "individuals with gstt1 null genotype",
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   "text": "polycythemia vera (pv), and chronic myeloid leukemia (cml)",
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   "articlesIDs": [
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  {
   "text": "parents of children with cleft lip/palate",
   "score": 12.000436782836914,
   "articlesIDs": [
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   "text": "patients with either pv or et. in fact, patients with mf",
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   "text": "donor-recipient sex combination",
   "score": 11.99011516571045,
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   "text": "patients with acute graft-versus-host-disease",
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   "articlesIDs": [
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   "text": "homozygotic carriership of gstt1 \"zero\" allele",
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  {
   "text": "patients with joint 677ct/1298ac or 677tt/1298cc genotypes",
   "score": 11.972128868103027,
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  {
   "text": "recipient/donor cytomegalovirus-seronegative versus either positive",
   "score": 11.953521728515625,
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  {
   "text": "mthfr 677 c\u003et polymorphism",
   "score": 11.950090408325195,
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  {
   "text": "light (≤ 1 drink/day) and moderate to heavy (\u003e1 drink/day) alcohol drinking",
   "score": 11.943075180053711,
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   "text": "male gender",
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   "text": "patient age and sex, donor-recipient sex combination",
   "score": 11.934711456298828,
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   "text": "air pollution",
   "score": 11.931768417358398,
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   "text": "cml patients of male sex, aged ≥ 60",
   "score": 11.922140121459961,
   "articlesIDs": [
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  {
   "text": "a low bmi (\u003c20)",
   "score": 11.918123245239258,
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   "text": "having received either stem cell transplantation or interferon-α treatment",
   "score": 11.90552043914795,
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   "text": "female marrow donors for male recipients",
   "score": 11.876357078552246,
   "articlesIDs": [
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  {
   "text": "hla b46 and dr9 loci and the a2b46dr9 haplotype, while female donors",
   "score": 11.875521659851074,
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  {
   "text": "diagnosis and gender",
   "score": 11.854966163635254,
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  {
   "text": "recipients of allogeneic hct using busulfan-cyclophosphamide conditioning",
   "score": 11.84135627746582,
   "articlesIDs": [
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  {
   "text": "leukocytosis, and thrombosis",
   "score": 11.834684371948242,
   "articlesIDs": [
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  {
   "text": "patients with pv, and 1.6 (95% ci: 1.3-2.0) for patients with cml",
   "score": 11.819670677185059,
   "articlesIDs": [
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   "text": "leukemia diagnosis",
   "score": 11.808990478515625,
   "articlesIDs": [
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  {
   "text": "residence in houses built with tuff, and smoking",
   "score": 11.796756744384766,
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   "text": "donor-recipient sex combination, histocompatibility",
   "score": 11.777616500854492,
   "articlesIDs": [
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   "text": "wine intake",
   "score": 11.771490097045898,
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   "text": "predisposing genetic factors, high doses of bcr-abl tkis",
   "score": 11.769041061401367,
   "articlesIDs": [
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  {
   "text": "white/black versus asian/hispanic race",
   "score": 11.760080337524414,
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   "text": "a leukemia diagnosis",
   "score": 11.755036354064941,
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   "text": "female patients with metabolically unhealthy normal weight",
   "score": 11.737074851989746,
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   "text": "high body mass index (5.0%), occupational exposure to benzene",
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   "text": "patient age and sex, donor-recipient sex combination, histocompatibility",
   "score": 11.722213745117188,
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   "text": "advanced age, leukocytosis, and thrombosis",
   "score": 11.716320037841797,
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   "text": "hla-a11",
   "score": 11.714666366577148,
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  {
   "text": "677ct and 1298ac genotypes",
   "score": 11.683250427246094,
   "articlesIDs": [
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   "text": "sequential use of potent tkis",
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   "text": "calreticulin (calr)",
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   "text": "radiotherapy, chemotherapy, and presence of hormonal receptors",
   "score": 11.640663146972656,
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   "text": "chronic graft-versus-host disease",
   "score": 11.639162063598633,
   "articlesIDs": [
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  {
   "text": "female gender (of both recipient and donor)",
   "score": 11.6383695602417,
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  {
   "text": "male gender, blacks, unmarried, and mm",
   "score": 11.623598098754883,
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   "text": "vegfr2 mutant t-allele",
   "score": 11.617313385009766,
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   "text": "1298cc genotype carriers",
   "score": 11.60669231414795,
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   "text": "higher categories of whr among women",
   "score": 11.602773666381836,
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   "text": "dose-response pattern",
   "score": 11.592129707336426,
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   "text": "smoking and high body mass index (bmi) in females",
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   "text": "patients with anll/nhl were older at diagnosis of hodgkin's disease",
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   "text": "fair skin, a history of excessive ultraviolet light exposure",
   "score": 9.270167350769043,
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   "text": "the type of bmt donor (allogeneic matched donor v mismatched or unrelated)",
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   "text": "received high cumulative doses of prednisone (3.4-14 g/m2)",
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  {
   "text": "chronic lymphocytic leukemia (cll)",
   "score": 9.138461112976074,
   "articlesIDs": [
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  {
   "text": "anaerobic decontamination",
   "score": 9.030570983886719,
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   "text": "the frequency of vegfr2 mutant t-allele",
   "score": 9.000934600830078,
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   "text": "vegfr2 at genotype",
   "score": 8.995767593383789,
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   "text": "the 1236 tt",
   "score": 8.988525390625,
   "articlesIDs": [
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  {
   "text": "for any alcohol drinking",
   "score": 8.951800346374512,
   "articlesIDs": [
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  {
   "text": "with a dose-response pattern",
   "score": 8.907233238220215,
   "articlesIDs": [
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  {
   "text": "in gist patients",
   "score": 8.902382850646973,
   "articlesIDs": [
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  {
   "text": "high doses of steroids or local irradiation involving femoral heads",
   "score": 8.896011352539062,
   "articlesIDs": [
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  {
   "text": "sdi",
   "score": 8.847007751464844,
   "articlesIDs": [
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  {
   "text": "in recipients of tcd ud-hsct, a match for dpb1",
   "score": 8.839204788208008,
   "articlesIDs": [
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  {
   "text": "chronic myeloid leukemia (cml), and chronic lymphocytic leukemia (cll)",
   "score": 8.80604362487793,
   "articlesIDs": [
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  },
  {
   "text": "both the c677t and a1298c polymorphisms",
   "score": 8.78400993347168,
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  {
   "text": "combinations of the \"zero\" gstm1 and gstt1 genotypes",
   "score": 8.764123916625977,
   "articlesIDs": [
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  {
   "text": "polyomavirus sv40",
   "score": 8.75009536743164,
   "articlesIDs": [
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  {
   "text": "in individuals with gstt1 null genotype",
   "score": 8.706047058105469,
   "articlesIDs": [
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  {
   "text": "patients treated for hodgkin's disease as adolescents",
   "score": 8.690320014953613,
   "articlesIDs": [
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  },
  {
   "text": "acute myeloid leukemia (aml), chronic myeloid leukemia (cml)",
   "score": 8.680206298828125,
   "articlesIDs": [
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  },
  {
   "text": "years of exposure to different chlorination disinfection by-product indexes",
   "score": 8.665189743041992,
   "articlesIDs": [
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  {
   "text": "the age older than 60 years",
   "score": 8.606218338012695,
   "articlesIDs": [
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  {
   "text": "chronic myeloid leukemia under treatment with nilotinib",
   "score": 8.551506042480469,
   "articlesIDs": [
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  {
   "text": "karnofsky performance score less than 90 versus 90 to 100",
   "score": 8.548480033874512,
   "articlesIDs": [
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  {
   "text": "patients under treatment with nilotinib",
   "score": 8.437409400939941,
   "articlesIDs": [
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  },
  {
   "text": "advanced age, leukocytosis, and history of thrombosis",
   "score": 8.425895690917969,
   "articlesIDs": [
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  }
 ]
}