H00010.json

{
 "id": "H00010",
 "disease": {
  "id": "H00010",
  "names": [
   "Multiple myeloma"
  ],
  "dbLinks": {
   "icd10": [
    "C90.0"
   ],
   "mesh": [
    "D009101"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
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   "text": "patients with as",
   "score": 14.083839416503906,
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  {
   "text": "patients infected with hbv",
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  {
   "text": "those with diabetes",
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  {
   "text": "alan",
   "score": 13.790884971618652,
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  {
   "text": "toluene and xylene",
   "score": 13.789721488952637,
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  {
   "text": "patients with gn, especially amyloidosis",
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   "text": "obesity and increased bmi",
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  {
   "text": "chronic hepatitis b",
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  {
   "text": "benzene, toluene and xylene",
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  {
   "text": "patients with smoldering multiple myeloma (smm)",
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    "32236162"
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   "text": "hemodialysis treatment, male sex, old age",
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   "text": "systemic lupus erythematosus",
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   "text": "prior surgery",
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   "text": "alan (risk ratio = 1.02, p = 0.0369) and urbanization",
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   "text": "employees exposed to engine exhaust",
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   "text": "prior surgery, immunomodulatory drug use",
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   "text": "male sex, high comorbidity burden, anemia, and hypercalcemia",
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   "text": "hemodialysis treatment, male sex, old age, and catastrophic illness",
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   "text": "obesity or high bmi",
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   "text": "low hdl cholesterol and/or apolipoprotein a1",
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   "text": "patients with lymphoid malignancies",
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   "text": "non-igg (hr = 2.84, ci:1.68-4.80, p = 0.0001), high monoclonal (m) protein",
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   "text": "multiple myeloma/paraproteinemia",
   "score": 13.184040069580078,
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   "text": "hodgkin lymphoma (hl)",
   "score": 13.15715503692627,
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   "text": "adults with hm in general and patients with lymphoid malignancies",
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   "text": "cirrhosis, multiple myeloma/paraproteinemia",
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   "text": "extensive osteolytic activity",
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   "text": "combined local dry season + la nina and combined local dry season + el nino",
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   "text": "serum m-protein \u003e2 g/dl",
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   "text": "low hdl levels",
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   "text": "tnfα-857 c/t",
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   "text": "male gender",
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   "text": "advanced alveolar bone loss and missing teeth",
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   "text": "a previous diagnosis of hl and pmf",
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   "text": "immunoparesis, age ≥69 years",
   "score": 12.93016242980957,
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   "text": "age ≥ 55 years, exposure to pollution",
   "score": 12.928653717041016,
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   "text": "bone marrow plasma cells ⩾20%",
   "score": 12.925972938537598,
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   "text": "κ light chain isotype, previous cerebrovascular events, and renal impairment",
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   "text": "iflc \u003e100 mg/l",
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   "text": "age \u003e65 years and iflc \u003e100 mg/l",
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   "text": "older age, male sex, black race, and family history of mgus",
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   "text": "cirrhosis, multiple myeloma/paraproteinemia, and anemia of chronic disease",
   "score": 12.912250518798828,
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   "text": "elevated ldh",
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   "text": "iss ii (hr 1.6; p = 0.0004) and issiii (hr 1.8; p = 0.0004) and elevated ldh",
   "score": 12.895509719848633,
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   "text": "increased cumulative doses of alkylating therapy with melphalan",
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   "text": "firefighters, hairdressers, and employees exposed to engine exhaust",
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   "text": "bmi ≥ 25 (hr = 2.14,ci:1.05-4.36, p = 0.04), non-igg",
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   "text": "ser37 + phe37 in hla-drb1",
   "score": 12.864599227905273,
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   "text": "obesity, and twice a week carfilzomib schedule",
   "score": 12.862821578979492,
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   "text": "a history of infertility",
   "score": 12.857678413391113,
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   "text": "patients with elevated serum flc",
   "score": 12.855844497680664,
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   "text": "diabetes mellitus, cerebrovascular disease",
   "score": 12.851161003112793,
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   "text": "acute renal failure, lupus, vasculitis, cirrhosis",
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   "text": "african americans",
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   "text": "recent use of permethrin",
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   "text": "human herpesvirus 8 (hhv-8) is the causative agent of kaposi's sarcoma (ks)",
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   "text": "moderate drinkers (ahr, 0.83; 95% ci, 0.76-0.91), and heavy drinkers",
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   "text": "after exposure to high doses of nitrosamines (potential inhalation intake)",
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   "text": "vitamin d deficiency is fairly common among patients with mm",
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   "text": "cardiovascular disease, hypertension; model b-diabetes mellitus",
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   "text": "chronic inflammation, hyperinsulinaemia and hyperglycaemia",
   "score": 8.62407112121582,
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  {
   "text": "in patients with a fracture after mm diagnosis",
   "score": 8.581974983215332,
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  {
   "text": "dental prostheses; cancer disease, in particular multiple myeloma",
   "score": 8.569604873657227,
   "articlesIDs": [
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  {
   "text": "'tt vs. cc + tc' of tnfα-857 c/t are correlated with mm risk. tnfα-857 c/t",
   "score": 8.567900657653809,
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  {
   "text": "minor allele frequency (maf)",
   "score": 8.557428359985352,
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  {
   "text": "elevated scd30",
   "score": 8.550658226013184,
   "articlesIDs": [
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  {
   "text": ", advanced alveolar bone loss and missing teeth",
   "score": 8.5279541015625,
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  {
   "text": "autoimmune diseases (aids)",
   "score": 8.525760650634766,
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  {
   "text": ", and marrow plasma cell infiltration \u003e20%",
   "score": 8.512529373168945,
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   "text": "one roh at chromosome 9q21",
   "score": 8.508306503295898,
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  {
   "text": "patients with acute myeloid leukemia",
   "score": 8.506601333618164,
   "articlesIDs": [
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  {
   "text": "l-asparaginase in treatment of acute lymphoblastic leukemia",
   "score": 8.498987197875977,
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  {
   "text": "sepsis (or = 1.66; 95% ci = 1.524-1.621). chemotherapy",
   "score": 8.498258590698242,
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  {
   "text": "alterations in adipokine pathophysiology",
   "score": 8.483545303344727,
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  {
   "text": "age \u003e75 years and congestive heart failure",
   "score": 8.483253479003906,
   "articlesIDs": [
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  {
   "text": "patients with chronic myeloid leukemia (cml) for ps0rs1c1-rs2285803,",
   "score": 8.47882080078125,
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  {
   "text": "among patients with hematologic malignancies, african americans",
   "score": 8.465144157409668,
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}