H00012.json

{
 "id": "H00012",
 "disease": {
  "id": "H00012",
  "names": [
   "Polycythemia vera"
  ],
  "dbLinks": {
   "icd10": [
    "D45"
   ],
   "mesh": [
    "D011087"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
  {
   "text": "patients with chronic myeloproliferative neoplasms",
   "score": 13.869861602783203,
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  {
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   "text": "jak2 617v\u003ef homozygosity",
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   "text": "adolescent obesity",
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  {
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  {
   "text": "patients with polycythemia vera (pv)",
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  {
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   "text": "h. pylori infection",
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   "text": "patients with pv and cld",
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   "text": "patients with mpns",
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   "text": "busulphan exposure",
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   "text": "blood donation",
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   "text": "mpn treatment, increased uric acid, and lactate dehydrogenase levels",
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   "text": "patients with a white blood cell count above 15 x 10(9)/l",
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   "text": "c677t mutation in 5,10-methylenetetrahydrofolate reductase (mthfr)",
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   "text": "patients with leukocytosis (leukocyte count \u003e10 × 109 l-1)",
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   "text": "baseline leukocytosis in et and pv patients",
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   "text": "ever use of hormone therapy (ht)",
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   "text": "increased myeloproliferation",
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   "text": "white cell count\u003e12×10 /l, and the presence of jak2 v617f mutation",
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   "text": "patients harboring greater than 75% jak2(v617f) allele",
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   "text": "older age, increased myeloproliferation",
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   "text": "glucocorticoid receptor a3669g",
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   "text": "polycythemia vera (pv) in 18%, and chronic lung disease (cld)",
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   "text": "increasing age and previous thrombosis",
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   "text": "prefibrotic primary mf (pmf)",
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   "text": "hypertension, smoke, obesity, dyslipidemia, and diabetes",
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   "text": "combination of gstm1 null genotype and cyp1a1 m1 (t6235c) genotype",
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   "text": "patients with et, 1.4 (95% ci: 1.3-1.5) for patients with pv",
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   "text": "variant allele at the homozygous state (g/g)",
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   "text": "obstructive sleep apnea (osa) in 29%, polycythemia vera (pv)",
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   "text": "carriership of fv leiden",
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   "text": "high blood pressure (p = 0.001), hyperlipidaemia",
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   "text": "trans men using testosterone",
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   "text": "age more than 60 years (p = .03; hazard ratio [hr] = 1.7), thrombosis history",
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   "text": "autoimmune conditions, some occupational exposures, and blood donation",
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   "text": "combination of aspirin and anticoagulants",
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   "text": "male sex (91% increased risk; p = 0.022), and hydroxycarbamide exposure",
   "score": 12.066715240478516,
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   "text": "tobacco use, hypertension, or diabetes mellitus",
   "score": 12.049568176269531,
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   "text": "cigarette smoking habits, hypertension, diabetes, obesity and dyslipidemia",
   "score": 12.03956127166748,
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   "text": "advanced age and history of thrombosis",
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   "text": "elevated opg levels",
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   "text": "age and high blood pressure",
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   "text": "mpn patients",
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   "text": "homozygous et patients",
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   "text": "neutrophil-to-lymphocyte ratio (nlr)",
   "score": 11.962007522583008,
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   "text": "advanced age, leukocytosis, reticulin fibrosis",
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   "text": "individuals with a previous history of thrombosis",
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   "text": "patients with pv, and 1.6 (95% ci: 1.3-2.0) for patients with cml",
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   "text": "hypertension, diabetes, hyperlipidemia",
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   "text": "af and pad",
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   "text": "white blood cell count \u003e13 × 10(9) /l and thrombo-embolism at diagnosis",
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   "text": "age \u003e70 years",
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   "score": 11.881460189819336,
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   "text": "4g/4g polymorphism of pai-1 gene and infection",
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   "text": "leukocytosis, and thrombosis",
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   "text": "polycythemia vera (pv), and chronic myeloid leukemia (cml)",
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   "text": "hypertension, diabetes, hyperlipidemia and normal karyotype",
   "score": 11.829984664916992,
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   "text": "acquired von willebrand syndrome, and primary myelofibrosis",
   "score": 11.827241897583008,
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   "text": "patients with myeloproliferative neoplasms (mpn)",
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   "text": "jak2 v617f positive patients",
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   "text": "advanced age, leukocytosis, reticulin fibrosis, splenomegaly",
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   "text": "hyperproliferative features and/or coexistent cardiovascular risk factors",
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   "text": "advanced age, leukocytosis, and thrombosis",
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   "text": "essential thrombocythemia (et), and primary myelofibrosis (pmf)",
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