H00016.json

{
 "id": "H00016",
 "disease": {
  "id": "H00016",
  "names": [
   "Oral cancer"
  ],
  "dbLinks": {
   "icd10": [
    "C00",
    "C01",
    "C02",
    "C03",
    "C04",
    "C05",
    "C06"
   ],
   "mesh": [
    "D009062"
   ]
  },
  "category": "Cancer",
  "description": "Oral cancer refers to a subgroup of head and neck malignancies that develop at the lips, tongue, salivary glands, gingiva, floor of the mouth, oropharynx, buccal surfaces and other intra-oral locations, according to the International Classification of Diseases. Nevertheless, the term is synonymous to squamous cell carcinoma (SCC) of oral mucosal origin that accounts for more than 90% of all malignant presentations at the aforementioned anatomical sites. Worldwide, oral SCC (OSCC) is the sixth most common cancer; more than 300,000 new cases are diagnosed each year. The development of OSCC is a multistep process requiring the accumulation of multiple genetic alterations, influenced by a patient's genetic predisposition as well as by environmental influences, including tobacco, alcohol, chronic inflammation, and viral infection. The genetic changes include activation of the epidermal growth factor receptor (EGFR), alterations of tumor suppressors p53 and p16, and cyclin D1 overexpression."
 },
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   "text": "performing mandibular surgery",
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   "text": "aged 45-64 years, divorce, low educational level, presence of diabetes",
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   "text": "tobacco smoking, chewing of betel quid with and/or without tobacco chewing",
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   "score": 9.980953216552734,
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   "score": 9.974306106567383,
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   "text": "rs2051526 (etv6), rs6021247 (nfatc2), rs3757769 (snd1), rs7085532 (tcf7l2)",
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   "score": 9.948587417602539,
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   "score": 9.397130012512207,
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   "text": "human papilloma virus (hpv), the causal agent of cervical cancer",
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   "score": 9.392119407653809,
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   "text": "use of smokeless tobacco (toombak)",
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   "text": "the slaked lime present in the betel quid, with or without areca nut",
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   "text": "exposure to e-cigarettes",
   "score": 8.708978652954102,
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   "text": "consumption of smokeless tobacco, such as and",
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   "text": "unemployed/housewives",
   "score": 8.697437286376953,
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   "text": "a smokeless tobacco product (naswar)",
   "score": 8.694503784179688,
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   "text": "while c allele of xpg g/c polymorphism",
   "score": 8.693017959594727,
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   "text": "cocaine was the most common drug used (77.15%), followed by marijuana",
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   "text": "hpv) positive oropharyngeal squamous cell carcinoma (opc)",
   "score": 8.682292938232422,
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   "text": "hematopoietic stem cell transplant (hsct), patients",
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   "text": "marital status",
   "score": 8.670799255371094,
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   "text": "the allelic frequencies of tnfa and lta snps",
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   "text": "persons aged 65+ and/or born in india, china, or taiwan",
   "score": 8.664124488830566,
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  {
   "text": "programmed cell death 6 (pdcd6)",
   "score": 8.660964965820312,
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   "text": "some specific bacterial strains",
   "score": 8.657175064086914,
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   "text": "all three asian subgroups",
   "score": 8.65361213684082,
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   "text": "preceding lichenoid area",
   "score": 8.649847030639648,
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   "text": "being female",
   "score": 8.648823738098145,
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   "text": "for smoking amount",
   "score": 8.64703369140625,
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  {
   "text": "the grs and bq chewing interaction",
   "score": 8.638883590698242,
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  {
   "text": "khat or qat (catha edulis)",
   "score": 8.636688232421875,
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  {
   "text": "oral cavity cancers (occ)",
   "score": 8.63593864440918,
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   "text": "there are sms in conjunction to betel quid chewing",
   "score": 8.628387451171875,
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   "text": "link between hpv and oral cancer and the transmission of hpv via oral sex",
   "score": 8.622568130493164,
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  {
   "text": ", tobacco smoking (including cigarettes, waterpipe, and pipe)",
   "score": 8.616169929504395,
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  {
   "text": "tricyclic antidepressants",
   "score": 8.61310863494873,
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   "text": "east asia (rr, 1.46; 95% ci, 1.21-1.77; i = 36.6%). for hnc subtypes, t2dm",
   "score": 8.60738754272461,
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  {
   "text": "diabetes (p=0.033), preoperative serum albumin level",
   "score": 8.599960327148438,
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   "text": "in sd patients",
   "score": 8.59886646270752,
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   "text": "a late-life sensitive period (\u003e50 years of age) for tobacco smoking",
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   "text": "male ≥ 60 pack-year current smokers",
   "score": 8.598283767700195,
   "articlesIDs": [
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  {
   "text": "lichenoid lesion (23.7%) were the most 3 clinical subtypes of opmd",
   "score": 8.595388412475586,
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  {
   "text": "patients with concordant nasopharyngeal cancer",
   "score": 8.593528747558594,
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   "text": "smoking (24.2%); smoking + drinking were most common among chinese",
   "score": 8.582304000854492,
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  {
   "text": "tea consumption combined with smoking or/and alcohol drinking",
   "score": 8.573310852050781,
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  {
   "text": "the 869t/c polymorphism of the tgf-ß1 gene",
   "score": 8.573135375976562,
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  {
   "text": "the participants with g/g homozygotes",
   "score": 8.553908348083496,
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   "text": "betel nut consumption",
   "score": 8.55240535736084,
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  {
   "text": "highest versus the lowest or no category consumption of coffee",
   "score": 8.546272277832031,
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  {
   "text": "habit stimulation",
   "score": 8.544021606445312,
   "articlesIDs": [
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  {
   "text": "rs9862 variants",
   "score": 8.5316162109375,
   "articlesIDs": [
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  {
   "text": "ww domain-containing oxidoreductase (wwox)",
   "score": 8.52065658569336,
   "articlesIDs": [
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  {
   "text": "genetically proxied body mass index (bmi",
   "score": 8.517932891845703,
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  {
   "text": "alcohol and tobacco use, include poor oral hygiene",
   "score": 8.514375686645508,
   "articlesIDs": [
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  },
  {
   "text": "'g' allele of cyp3a5*3",
   "score": 8.510167121887207,
   "articlesIDs": [
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  {
   "text": "lesion site, clinical appearance, tobacco use",
   "score": 8.508735656738281,
   "articlesIDs": [
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  {
   "text": ", a disadvantageous sep",
   "score": 8.503803253173828,
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  {
   "text": "in paan consumers",
   "score": 8.497011184692383,
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 ]
}