H00019.json

{
 "id": "H00019",
 "disease": {
  "id": "H00019",
  "names": [
   "Pancreatic cancer",
   "SUPERGRP  Solid tumor [DS:H02421]"
  ],
  "dbLinks": {
   "icd10": [
    "C25"
   ],
   "mesh": [
    "D010190"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
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  {
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  {
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   "text": "lack of hot pack use",
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   "text": "new-onset chronic pancreatitis, new-onset diabetes",
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   "text": "diabetic mellitus (dm)",
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   "text": "black men between 40-59 years old and overweight",
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   "text": "diabetes mellitus, smoking history",
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   "text": "familial pancreatic cancer, diabetes mellitus",
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   "text": "mpd of greater than 3 mm, diabetes mellitus",
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   "text": "genetic predisposition index for chronic or aggressive periodontitis",
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   "text": "high sua levels",
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   "text": "high plt count",
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   "text": "family history of cp, lower bmi%, genetic and obstructive factors",
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   "text": "opium users",
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   "text": "symptomatic cholelithiasis",
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   "text": "long-term users of ppis",
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   "text": "tobacco use and chronic pancreatitis",
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   "text": "high platelet (plt) count",
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   "text": "alanine aminotransferase (or = 2.06, 95% ci (1.39, 3.06)). gallstone",
   "score": 9.241252899169922,
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   "text": "fewer comorbidities",
   "score": 9.238595008850098,
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   "text": "branched-chain amino acids (bcaa)",
   "score": 9.238585472106934,
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   "text": "states that have the highest quartile of 1,3-d use",
   "score": 9.232255935668945,
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   "text": "those in the highest quartile of fpg variability by sd",
   "score": 9.230743408203125,
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   "text": "alternative healthy eating index-2010 (ahei-2010)",
   "score": 9.227676391601562,
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  {
   "text": "consumption of milk, cheese and yogurt",
   "score": 9.226490020751953,
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  {
   "text": "in systemic lupus erythematosus (sle)",
   "score": 9.226055145263672,
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  {
   "text": "the tert rs10069690 polymorphism",
   "score": 9.224905014038086,
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  {
   "text": "preceding diabetes and chronic pancreatitis were strongly associated with pc",
   "score": 9.221658706665039,
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  {
   "text": "high but also low body mass index (bmi)",
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   "text": "volume of mpd plus any cystic lesion/bsa, volume of pancreatic parenchyma/bsa",
   "score": 9.197234153747559,
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   "text": "high alcohol intake. the increased risk for heavy drinking",
   "score": 9.19158935546875,
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   "text": "plateletcrit (or = 0.57, 95% ci (0.42, 0.78)), and alanine aminotransferase",
   "score": 9.172316551208496,
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   "text": "a lower intake of fat-soluble vitamins",
   "score": 9.171085357666016,
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   "text": "among never smokers",
   "score": 9.165922164916992,
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  {
   "text": "il.\n\nconclusion:\nwe concluded a weak association between dietary gi/gl",
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   "text": "middle- and low-volume hospitals",
   "score": 9.144224166870117,
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  {
   "text": "enhanced procoagulant activity of tissue factor after chemotherapy",
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  {
   "text": "mutation of the prss-1 gene",
   "score": 9.141132354736328,
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   "text": "obesity, first-degree relative with be or esophageal adenocarcinoma [eac])",
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  {
   "text": "bmi ≥30 kg/m , prior anticoagulation",
   "score": 9.124883651733398,
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  {
   "text": "the ever use of oc",
   "score": 9.103843688964844,
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  {
   "text": "the opium use",
   "score": 9.100977897644043,
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  {
   "text": "parenchymal calcification (hr 0.213, p = 0.003), pancreatic duct stricture",
   "score": 9.098848342895508,
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  {
   "text": "hcv seropositivity in females in the research group aged 1-59 years old",
   "score": 9.097740173339844,
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  {
   "text": "minimally invasive surgery (mis)",
   "score": 9.081939697265625,
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  {
   "text": "red meat consumption, alcohol consumption, tea, rice, viruses such as and",
   "score": 9.077621459960938,
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  {
   "text": "the cyst diameter at diagnosis (≥ 14 mm)",
   "score": 9.069147109985352,
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  {
   "text": "relatives of female patients with pc and patients diagnosed at age \u003c 65 years",
   "score": 9.0624361038208,
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  {
   "text": "variant with an effect on the p16ink4a protein",
   "score": 9.058511734008789,
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  {
   "text": "in fdr and more distant relatives of patients with pc",
   "score": 9.046859741210938,
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  {
   "text": ", working as a veterinarian in places had animals and different poultry birds",
   "score": 9.045169830322266,
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  {
   "text": "cytotoxin-associated gene a strain of",
   "score": 9.035833358764648,
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  {
   "text": "white, with a partner",
   "score": 9.028705596923828,
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  {
   "text": "insulin initiators",
   "score": 9.027769088745117,
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  {
   "text": "extracellular vesicles (ev)",
   "score": 9.025390625,
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  {
   "text": "with high alcohol intake",
   "score": 9.023932456970215,
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  {
   "text": "patients with stage iii pancreatic head cancer in the mis group",
   "score": 9.009123802185059,
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  {
   "text": "the autoimmune form of pancreatitis",
   "score": 9.009100914001465,
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  {
   "text": "the size of the ipmn and the diameter of the main pancreatic duct",
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  {
   "text": "rabeprazole",
   "score": 9.000243186950684,
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  {
   "text": "composite scores 2, 3, 4, 5, 6 to 7",
   "score": 8.995336532592773,
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  {
   "text": "group of people with aip",
   "score": 8.994686126708984,
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  {
   "text": "obesity, diet, and type 2 diabetes",
   "score": 8.99325942993164,
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  {
   "text": "new-onset diabetes an early manifestation of the tumor",
   "score": 8.978469848632812,
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  {
   "text": "age (hr 4.830, p = 0.006), parenchymal calcification",
   "score": 8.977758407592773,
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  {
   "text": "a low gnri",
   "score": 8.9777250289917,
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  {
   "text": "depression",
   "score": 8.975814819335938,
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  {
   "text": "chromosome 19p13.3 (rs2656937",
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  {
   "text": ", secondhand smoke exposure during childhood",
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  {
   "text": "among never smokers, there were elevated ors for known oral pathogens",
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  {
   "text": "new-onset dm (nodm)",
   "score": 8.968123435974121,
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   "text": "and family history of cancers",
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  {
   "text": "diabetes, alcohol consumption and sedentary lifestyle",
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  {
   "text": "in patients with pud",
   "score": 8.950246810913086,
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   "text": "those with pancreatic cancer susceptibility gene variants",
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   "text": "patients with diabetes secondary to acute and chronic pancreatitis",
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  {
   "text": "perioperative inotropes",
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  {
   "text": "lumber and wood products industries. leather tanning",
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   "text": "the gnri",
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  {
   "text": "a smaller duct diameter",
   "score": 8.930078506469727,
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  {
   "text": "hyperinsulinaemia and hyperglycaemia, sex steroids, and microbiome",
   "score": 8.928804397583008,
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  {
   "text": "a 6-month drug use lag period",
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  {
   "text": "rs1818613",
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  {
   "text": "obesity- and diabetes mellitus (dm)",
   "score": 8.924002647399902,
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  {
   "text": "patients with familial pancreas cancer, hereditary pancreatitis",
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  {
   "text": "recurrent or chronic forms of pancreatitis",
   "score": 8.91522216796875,
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  {
   "text": "kindreds with familial pc and individuals with hereditary pc syndrome",
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   "text": "chronic inflammation",
   "score": 8.891535758972168,
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  {
   "text": ", working as a hunter for game animals",
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   "text": "high-income regions or large population regions",
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   "text": "genetic variants) as well as pancreas-specific factors",
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   "text": "affected individuals with hereditary pancreatitis due to inherited prss1",
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   "text": "intron 5 of the transmembrane protein 163 (tmem163)",
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   "text": "a familial pancreatic cancer syndrome",
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   "text": ", those in areas in the highest quintile",
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   "text": "after exposure to high doses of nitrosamines (potential inhalation intake)",
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   "text": "presence of multilocular cysts, and an inconsistent mpd caliber",
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   "text": "frequency of alcohol consumption (1-2 and ≥5 days/week",
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   "text": ". ifg combined with heavy alcohol consumption (30 g/day)",
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   "text": "areas with high socio-demographic index (sdi)",
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   "text": "age at which alcohol consumption was started",
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 ]
}