risks-factors / H00029.json
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risk factors
c8f8834 unverified
{
"id": "H00029",
"disease": {
"id": "H00029",
"names": [
"Vulvar cancer"
],
"dbLinks": {
"icd10": [
"C51"
],
"mesh": [
"D014846"
]
},
"category": "Cancer"
},
"riskFactors": [
{
"text": "infection with hsv2",
"score": 13.92982006072998,
"articlesIDs": [
"9337348"
]
},
{
"text": "infection with hpv16, and infection with hsv2",
"score": 13.91187858581543,
"articlesIDs": [
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]
},
{
"text": "patients with diagnosed lp",
"score": 13.77604866027832,
"articlesIDs": [
"28857160"
]
},
{
"text": "current smoking, infection with hpv16, and infection with hsv2",
"score": 13.772318840026855,
"articlesIDs": [
"9337348"
]
},
{
"text": "hpv infection",
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"articlesIDs": [
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},
{
"text": "immunosuppression",
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{
"text": "leucoplachia, 3) immunosuppression",
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"articlesIDs": [
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},
{
"text": "concurrent vin and age ≥70 years at time of lichen sclerosus diagnosis",
"score": 13.646574020385742,
"articlesIDs": [
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},
{
"text": "hpv infection, lesion sites of the upper vulva and histo-pathological changes",
"score": 13.605889320373535,
"articlesIDs": [
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]
},
{
"text": "hsv2 seropositivity",
"score": 13.602140426635742,
"articlesIDs": [
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]
},
{
"text": "atrophic vagina history, hpv infection",
"score": 13.595060348510742,
"articlesIDs": [
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]
},
{
"text": "hpv33",
"score": 13.5697603225708,
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]
},
{
"text": "low socio-cultural level, previous infection by human papilloma virus (hpv)",
"score": 13.533103942871094,
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]
},
{
"text": "educational level, smoking, history of vaginal atrophy, hpv infection",
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]
},
{
"text": "educational level, smoking, atrophic vagina history, hpv infection",
"score": 13.50228214263916,
"articlesIDs": [
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},
{
"text": "hpv31 and hpv33",
"score": 13.398041725158691,
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{
"text": "current cigarette smoking",
"score": 13.299531936645508,
"articlesIDs": [
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},
{
"text": "age \u003e50years, immunosuppression",
"score": 13.250007629394531,
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{
"text": "multiple sexual partners, a low socio-cultural level",
"score": 13.234737396240234,
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{
"text": "lower education and higher poverty",
"score": 13.22922134399414,
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{
"text": "immunosuppression, metasynchronous vaginal or intraepithelial neoplasia",
"score": 13.19765853881836,
"articlesIDs": [
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},
{
"text": "high-risk hpv infection",
"score": 13.192159652709961,
"articlesIDs": [
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},
{
"text": "polycystic ovary syndrome (pcos)",
"score": 13.186083793640137,
"articlesIDs": [
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},
{
"text": "age at time of lichen sclerosus diagnosis",
"score": 13.157415390014648,
"articlesIDs": [
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},
{
"text": "chronic vulvitis (in particular lichen sclerosus); 2) leucoplachia",
"score": 13.134468078613281,
"articlesIDs": [
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},
{
"text": "inguinofemoral lymphadenectomy, older age, body mass index (bmi)",
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]
},
{
"text": "advanced age (≥65 years)",
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},
{
"text": "adjacent lichen sclerosus or human papilloma-virus",
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},
{
"text": "young age at first sexual intercourse, multiple sexual partners",
"score": 13.058940887451172,
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},
{
"text": "women with high-risk hpv infection",
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{
"text": "hpv16 seropositivity",
"score": 13.031806945800781,
"articlesIDs": [
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},
{
"text": "subjects positive for hpv-16 antibodies",
"score": 13.02301025390625,
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{
"text": "lymphvascular space invasion, tumor stage, and depth of infiltration",
"score": 12.999351501464844,
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]
},
{
"text": "women with human papillomavirus-related gynecologic neoplasm",
"score": 12.995820999145508,
"articlesIDs": [
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]
},
{
"text": "immunosuppression, 4) coitus in a young woman with different partners",
"score": 12.979698181152344,
"articlesIDs": [
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},
{
"text": "obesity (body mass index≥30 kg/m2) and advanced age (≥65 years)",
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{
"text": "hpv infection (mostly hpv type 6 and 16)",
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},
{
"text": "gonorrhea",
"score": 12.913336753845215,
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{
"text": "local relapses at the site of the primary tumor or skin bridge recurrences",
"score": 12.906723976135254,
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{
"text": "hpv-16 seropositivity",
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},
{
"text": "minor alleles of the il10ra rs9610 3' utr snp",
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{
"text": "inflammation of vagina and vulva",
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},
{
"text": "human papillomavirus (hpv) exposure",
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{
"text": "tobacco smoking",
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},
{
"text": "inflammation of the vulva or vagina, and urogenital cancer",
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},
{
"text": "tobacco use, alcohol abuse, and hpv infection",
"score": 12.725552558898926,
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},
{
"text": "condylomata acuminata",
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{
"text": "ls",
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{
"text": "diabetes mellitus",
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},
{
"text": "autoimmune connective tissue disease (n = 2), renal transplant",
"score": 12.663978576660156,
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},
{
"text": "unsafe sex and human immunodeficiency virus infection",
"score": 12.632741928100586,
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},
{
"text": "chronic hepatitis (n = 1), schizophrenia",
"score": 12.623592376708984,
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},
{
"text": "alcohol drinking, unsafe sex and human immunodeficiency virus infection",
"score": 12.616022109985352,
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},
{
"text": "older age, body mass index (bmi), and radiation therapy",
"score": 12.544376373291016,
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{
"text": "a low socio-cultural level, previous infection by human papilloma virus (hpv)",
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{
"text": "immune depression",
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{
"text": "positive excision margins",
"score": 12.513158798217773,
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{
"text": "1 sd increase in bmi",
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{
"text": "previous infection by human papilloma virus (hpv) and smoking",
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{
"text": "herpes simplex virus type 2 seropositivity",
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{
"text": "serum 25(oh)d",
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{
"text": "women over 50 years",
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{
"text": "wound infection, inguinofemoral lymphadenectomy",
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{
"text": "history of genital warts",
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{
"text": "hpv infection, cigarette smoking",
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{
"text": "mets",
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{
"text": "vulval hpv",
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{
"text": "cigarette smoking, chronic skin disorders, and immunosuppression",
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{
"text": "young human immunodeficiency virus-seropositive women",
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{
"text": "occupational histories of private household maids and servants",
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{
"text": "advanced age and obesity",
"score": 12.236227035522461,
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{
"text": "vulval hpv (n = 3), diabetes mellitus",
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"text": "blood glucose and triglyceride concentrations",
"score": 12.22755241394043,
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{
"text": "women who reported a previous abnormal papanicolaou smear",
"score": 12.194961547851562,
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{
"text": "hiv-infected men and women",
"score": 12.191290855407715,
"articlesIDs": [
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{
"text": "hpv31 (hr:46.7(95%ci:4.21,518.4); p=0.02) and hpv33",
"score": 12.18088436126709,
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{
"text": "prior history of condyloma",
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{
"text": "women who reported a prior history of condyloma",
"score": 12.164798736572266,
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{
"text": "pretreatment infection from hpv31",
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{
"text": "men who have sex with men, hiv-infected men and women",
"score": 12.15371322631836,
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{
"text": "immunosuppression (or 2.08; 95%ci 1.42-3.06), metasynchronous vain or cin",
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"articlesIDs": [
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{
"text": "higher prevalence of smoking",
"score": 12.130398750305176,
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{
"text": "tnf region",
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"text": "higher education",
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"text": "number of sexual partners and herpes simplex virus type 2 seropositivity",
"score": 12.022245407104492,
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"text": "hiv-infected men and women, immunocompromised men and women",
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"text": "higher prevalence of smoking, alcohol drinking",
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"text": "women who were seropositive to herpes simplex virus type 2 (hsv-2)",
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"text": "history of hpv",
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"text": "current smokers",
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"text": "minor alleles of the il10ra rs4252314 intronic snp",
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{
"text": "young women with vulvar cancer tend to have early-stage disease, smoke",
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"text": "history of hpv, and have vin",
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"text": "women with in situ cervical cancer",
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"text": "smoking and immune depression",
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"text": "presence of lvsi",
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"text": "patients over 70 years of age",
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"text": "hpv infection, cigarette smoking, chronic skin disorders",
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"text": "prior histories of leukoplakia of the vulva",
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"text": "the mets",
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"text": "women 50-64",
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"text": "two synonymous il12rb2 snps",
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"text": "women participating in receptive anal intercourse",
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"text": "women with pcos",
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"text": "phimosis, chronic inflammation, and smoking",
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{
"text": "those larger than 1 cm",
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"text": "other specified noninflammatory disorders of vulva",
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"text": "lichen planus (lp)",
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{
"text": "a*0101-b*0801-cw*0701-drb1*0301-dqb1*0201",
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"text": "human development index, higher prevalence of smoking",
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"text": "chronic metabolic diseases such as cardiovascular illnesses, hypertension",
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{
"text": "gross domestic product per capita",
"score": 11.476448059082031,
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"text": "depth of invasion \u003e 5 mm",
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"text": "work in laundry, cleaning, and other garment services",
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"text": "histologic grade (proportion of undifferentiated tumor pattern)",
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"text": "older age, nonprivate insurance",
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"text": "leukoplakia of the vulva, inflammation of the vulva or vagina",
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"text": "human papillomavirus and cigarette smoking",
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"text": "have a history of hpv",
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{
"text": "black race",
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"text": "tumor thickness",
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"text": "smokers, 40% had human papillomavirus (hpv) exposure",
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{
"text": "hypertension, diabetes, and smoking",
"score": 11.375229835510254,
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"text": "concurrent vulvar intraepithelial neoplasia (vin",
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{
"text": "a history of cervical intraepithelial neoplasia (cin) or warts",
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"text": "generalized genital hpv infection",
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{
"text": "gstm1 null genotype",
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"text": "vascular involvement",
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"text": "patients with multifocal vulvar cancer",
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{
"text": "vin3 and vain3 are associated with hpv infection",
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"text": "have a history of hpv, and have vin",
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"text": "history of vulvar intraepithelial neoplasia (vin)",
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{
"text": "women with in situ vulvar cancer",
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{
"text": "patients with positive nodal status n1",
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"text": "coffee consumption",
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{
"text": "rare allele (a) of snp rs2239704 in the 5' utr of the lta gene",
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{
"text": "the tnf region",
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{
"text": "oncogenic hpv",
"score": 11.14990520477295,
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{
"text": "those who had radiotherapy or who had lymph nodes removed",
"score": 11.136198997497559,
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},
{
"text": "lack of circumcision, phimosis, chronic inflammation, and smoking",
"score": 11.12501335144043,
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{
"text": "chronic dermatologic diseases",
"score": 11.08041763305664,
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{
"text": "lichen sclerosus (ls)",
"score": 11.073441505432129,
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},
{
"text": "previous diagnosis of cin",
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"articlesIDs": [
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},
{
"text": "high-risk α-hpvs",
"score": 10.995946884155273,
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},
{
"text": "young women under 45 years of age",
"score": 10.960497856140137,
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},
{
"text": "depth of stromal invasion",
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{
"text": "family history of ovarian cancer",
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"text": "hiv-infected patients",
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{
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"text": "those who had lymph nodes removed or who were overweight or obese",
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{
"text": "vin iii is an hpv-related disease",
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{
"text": "capillary-like space involvement with the tumor",
"score": 10.384355545043945,
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{
"text": "older age, larger tumor size, and positive lns",
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{
"text": "high-risk hpv-associated. almost all of the types were high-risk α-hpvs",
"score": 10.373627662658691,
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{
"text": "hpv16, hpv18, hpv31 and hpv33",
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"text": "ls (or 2.3, 95% ci [1.2-4.3]) and lvsi",
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{
"text": "the presence of lvsi",
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{
"text": "the minor alleles of the il10ra rs9610 3' utr snp",
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{
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{
"text": "chronic inflammation, and smoking. the role of lichen sclerosus (ls)",
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{
"text": "high-risk human papillomavirus (hpv)",
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{
"text": "hiv-infected patients, homosexuals",
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{
"text": "figo stage at diagnosis",
"score": 10.106164932250977,
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{
"text": "hpv, age, smoking, education, diet, genital infections",
"score": 10.097469329833984,
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"text": "women 75 years and older",
"score": 10.088747024536133,
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{
"text": "women with the gstm1 null genotype",
"score": 10.035025596618652,
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{
"text": "the depth of invasion \u003e 5 mm",
"score": 9.899447441101074,
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{
"text": "untreated vin iii",
"score": 9.898979187011719,
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{
"text": "in patients over 70 years of age",
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{
"text": "poor differentiation",
"score": 9.84554672241211,
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{
"text": "older age, nonprivate insurance, and treatment at a lower case volume center",
"score": 9.786890029907227,
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{
"text": "patients who are receiving radiotherapy as an only treatment without surgery",
"score": 9.743602752685547,
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{
"text": "insurance type",
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{
"text": "patients with superficial vulvar cancer are tumor thickness",
"score": 9.72072982788086,
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{
"text": "infrequent pelvic examinations, socioeconomic status",
"score": 9.718778610229492,
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{
"text": "age 60 years or older and insurance type",
"score": 9.700414657592773,
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},
{
"text": "patients having midline involvement of vulvar cancer",
"score": 9.657840728759766,
"articlesIDs": [
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},
{
"text": "the depth of tumor invasion and the appearance of lymph-node metastasis",
"score": 9.638238906860352,
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},
{
"text": "squamous histology",
"score": 9.55854606628418,
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{
"text": "number of reported lifetime sexual partners",
"score": 9.525126457214355,
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},
{
"text": "women who present with high-grade vulvar squamous intraepithelial neoplasia",
"score": 9.495024681091309,
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{
"text": "black women",
"score": 9.47830581665039,
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{
"text": "socioeconomic status, immunosuppressive diseases",
"score": 9.425753593444824,
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{
"text": "in patients with positive nodal status n1",
"score": 9.411516189575195,
"articlesIDs": [
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{
"text": ": smoking and immune depression",
"score": 9.378583908081055,
"articlesIDs": [
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},
{
"text": "second transplantations",
"score": 9.346555709838867,
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{
"text": "those ≥80 years",
"score": 9.343717575073242,
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},
{
"text": "diseases of bartholin's gland",
"score": 9.326957702636719,
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{
"text": "with inflammation of vagina and vulva",
"score": 9.27956771850586,
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{
"text": "green vegetables",
"score": 9.21744155883789,
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{
"text": "the polycystic ovary syndrome (pcos)",
"score": 9.126771926879883,
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{
"text": "margin status, and depth of invasion",
"score": 9.088687896728516,
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{
"text": "oncogenic hpv subtypes",
"score": 9.052030563354492,
"articlesIDs": [
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},
{
"text": "ls in 27.7% ( = 113). in univariate analysis, ls",
"score": 9.039870262145996,
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},
{
"text": "metabolic syndrome (mets)",
"score": 9.039501190185547,
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},
{
"text": "young patients (below 45 years of age)",
"score": 8.988142967224121,
"articlesIDs": [
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},
{
"text": "hereditary ovarian cancer syndromes",
"score": 8.87454605102539,
"articlesIDs": [
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},
{
"text": "hpv-16 seropositivity was higher among smokers",
"score": 8.840088844299316,
"articlesIDs": [
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},
{
"text": "the human papillomavirus (hpv)",
"score": 8.834615707397461,
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},
{
"text": "vin1-2",
"score": 8.776548385620117,
"articlesIDs": [
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},
{
"text": "women reporting pap smears during their life",
"score": 8.775012016296387,
"articlesIDs": [
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},
{
"text": "poor differentiation (p = 0.04), and node count less than 9",
"score": 8.733672142028809,
"articlesIDs": [
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},
{
"text": "women diagnosed with vulvar cancer",
"score": 8.722959518432617,
"articlesIDs": [
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},
{
"text": "cin treated patients, mostly for cin3",
"score": 8.683904647827148,
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},
{
"text": "for the presence of lvsi",
"score": 8.586108207702637,
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},
{
"text": "minimal (negative groin nodes and lesion diameter less than or equal to 2 cm)",
"score": 8.482380867004395,
"articlesIDs": [
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},
{
"text": "the number of reported lifetime sexual partners",
"score": 8.417198181152344,
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}
]
}