H00030.json

{
 "id": "H00030",
 "disease": {
  "id": "H00030",
  "names": [
   "Cervical cancer"
  ],
  "dbLinks": {
   "icd10": [
    "C53"
   ],
   "mesh": [
    "D002583"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
  {
   "text": "diabetes and hypertension, and increased endometrial thickness",
   "score": 14.221538543701172,
   "articlesIDs": [
    "34566302"
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  },
  {
   "text": "women with 2 or more episodes of postmenopausal bleeding",
   "score": 14.208992004394531,
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  {
   "text": "high bmi",
   "score": 14.203670501708984,
   "articlesIDs": [
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  },
  {
   "text": "passive exposure to cigarette smoke at home, diabetes, and high bmi",
   "score": 14.152067184448242,
   "articlesIDs": [
    "34332564"
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  },
  {
   "text": "hr-hpv",
   "score": 14.137067794799805,
   "articlesIDs": [
    "36556165",
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  },
  {
   "text": "early age at first intercourse, hr-hpv",
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   "articlesIDs": [
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  },
  {
   "text": "hr-hpv, and hiv infections",
   "score": 14.049102783203125,
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  },
  {
   "text": "domestic secondhand smoke exposure, diabetes, and high bmi",
   "score": 14.048219680786133,
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  {
   "text": "increasing age, early age at first intercourse, hr-hpv",
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  },
  {
   "text": "early age at first intercourse, hr-hpv, and hiv infections",
   "score": 13.985895156860352,
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    "33512002"
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  },
  {
   "text": "pro/pro mutant homozygosity",
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  },
  {
   "text": "post-coital bleeding",
   "score": 13.970869064331055,
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    "35751302",
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  },
  {
   "text": "increasing age, early age at first intercourse, hr-hpv, and hiv infections",
   "score": 13.94822883605957,
   "articlesIDs": [
    "33512002"
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  },
  {
   "text": "human papillomavirus infection",
   "score": 13.920417785644531,
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  },
  {
   "text": "post-coital bleeding, history of sexually transmitted infections",
   "score": 13.90000057220459,
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  {
   "text": "hemoglobin, albumin, and total t lymphocyte count",
   "score": 13.881208419799805,
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  {
   "text": "history of smoking",
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  {
   "text": "high cpg island methylator phenotype (cimp)",
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  {
   "text": "age \u003c60 years old, history of previous abdominal/pelvic surgery, obesity",
   "score": 13.866148948669434,
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  {
   "text": "human papillomavirus infection, tct severity, abcg2, tdg, pcna",
   "score": 13.826505661010742,
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  {
   "text": "having multiple sexual partners, and history of smoking",
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   "text": "persistent hr-hpv infection",
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  {
   "text": "women with parity greater than four children, post-coital bleeding",
   "score": 13.788690567016602,
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  {
   "text": "history of previous abdominal/pelvic surgery, obesity, cervical cancer",
   "score": 13.784416198730469,
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   "text": "hr-hpv-positive women",
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   "text": "deep 1/3 interstitial infiltration",
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   "text": "cervical cancer, and open surgery",
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   "text": "those who had either diabetes or hypertension",
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   "text": "patient age, age at menarche, miscarriages",
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   "text": "females with sle/mctd or hiv",
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   "text": "hoxb13 p.gly84glu",
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   "text": "bacterial vaginosis (bv) and e6/e7 mrna",
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   "text": "concurrent reproductive tract infections",
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  {
   "text": "infection with human papillomavirus (hpv)",
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   "articlesIDs": [
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   "text": "patients with cancer and sars-cov-2 infection",
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   "text": "hpv16 positivity and nulliparity",
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   "text": "whole body fat-free mass (wbffm)",
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   "text": "menstrual history, history of pelvic infection, history of sti",
   "score": 13.481863975524902,
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   "text": "cd4+ cell count of \u003c200 cells/µl, persistent hr-hpv infection",
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   "text": "women with reproductive tract infections",
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   "text": "increasing nsp",
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   "text": "sexually transmitted infection, bleeding, and pelvic pain",
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   "text": "advanced stage, tumor size, adenocarcinoma, parametrial involvement",
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   "text": "genetic variant in the tnf-α gene (rs1800629)",
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   "text": "history of pelvic infection [aor = 2.82; 95% ci (1.21, 6.59)], history of sti",
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   "text": "multiparity (53.33%), menopause (66.66 %); taking contraception",
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   "text": "hpv-16 and hpv-18 infections",
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   "text": "high levels of d-dimer and a larger size of the cervical tumor",
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   "text": "marital status, education, sexually transmitted infection",
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   "text": "hpv31/33/35/52/58 infections",
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   "text": "rt, hpv",
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   "text": "patients with a diagnosis of menstrual irregularity",
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   "text": "plni, lvsi, pmi, bulky tumor, cui, or age over 40 years",
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   "text": "patient age, age at menarche, miscarriages, clinical stages",
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   "text": "positive family history of cervical cancer",
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   "text": "more than one-lifetime sexual partner",
   "score": 13.059639930725098,
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  {
   "text": "women with persistence of hpv infection after cervical excision",
   "score": 13.059579849243164,
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   "score": 13.051450729370117,
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   "score": 13.043487548828125,
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   "score": 13.04030990600586,
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   "score": 13.039909362792969,
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   "score": 13.037528991699219,
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   "score": 13.03499698638916,
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   "score": 13.029339790344238,
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   "score": 13.028955459594727,
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   "text": "partner's occupation other than being an employee, alcohol consumption",
   "score": 13.028202056884766,
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   "score": 13.027549743652344,
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   "score": 13.027128219604492,
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   "score": 13.021190643310547,
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  {
   "text": "xrcc3 rs861539, tnf-α rs1800629, and il-6 rs1800795",
   "score": 13.020940780639648,
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  {
   "text": "endline hiv viral-load ≥ 50 copies/ml",
   "score": 13.020593643188477,
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   "score": 13.01797866821289,
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   "score": 13.016827583312988,
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   "score": 13.009478569030762,
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   "score": 13.009418487548828,
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   "text": "high hiv rna viral loads",
   "score": 12.985678672790527,
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   "text": "individuals with at least two high-risk genotypes of cyp1a1/gstt1",
   "score": 12.98294734954834,
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  {
   "text": "c allele of taq1",
   "score": 12.978739738464355,
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   "score": 12.968193054199219,
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   "score": 12.967248916625977,
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   "score": 12.961727142333984,
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   "score": 12.955475807189941,
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   "score": 12.953432083129883,
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   "score": 12.941803932189941,
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   "score": 12.89534854888916,
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   "score": 12.886512756347656,
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   "score": 12.883612632751465,
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   "score": 12.83840560913086,
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   "text": "tobacco use, alcohol abuse, and hpv infection",
   "score": 12.836994171142578,
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   "text": "fam19a4/mir124-2 methylation, hpv16/18 and hpv16/18/31/33/45 genotyping",
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   "text": "smoking, drinking alcohol, and eating few fruits and vegetables",
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   "text": "international federation of gynecology and obstetrics (figo) stage",
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   "text": "giving birth for the first time before the age of 26 years",
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   "text": "stage iii/iv advanced disease, clear cell carcinoma",
   "score": 12.254399299621582,
   "articlesIDs": [
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  {
   "text": "std_hiv",
   "score": 12.252008438110352,
   "articlesIDs": [
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  {
   "text": "coital frequency per week",
   "score": 12.249813079833984,
   "articlesIDs": [
    "34124973"
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  },
  {
   "text": "type of vaginitis, history of hyperlipidemias",
   "score": 12.248207092285156,
   "articlesIDs": [
    "34766625"
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  {
   "text": "smoking and human papillomavirus (hpv) 16/18",
   "score": 12.247831344604492,
   "articlesIDs": [
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  },
  {
   "text": "current smokers, nonmarried and from rural areas",
   "score": 12.247806549072266,
   "articlesIDs": [
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  {
   "text": "ct, uup6, mh and mg infections",
   "score": 12.247191429138184,
   "articlesIDs": [
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  {
   "text": "workers occupationally exposed to tobacco, fungi or bacteria",
   "score": 12.237913131713867,
   "articlesIDs": [
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  {
   "text": "hpv-52",
   "score": 12.23662281036377,
   "articlesIDs": [
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  {
   "text": "women with husband's having multiple sexual partners",
   "score": 12.234203338623047,
   "articlesIDs": [
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  },
  {
   "text": "hpv-16 was the most prevalent, persistent infections of hpv-16/58",
   "score": 12.231335639953613,
   "articlesIDs": [
    "34535177"
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  },
  {
   "text": "women with two children",
   "score": 12.23077392578125,
   "articlesIDs": [
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  {
   "text": "testing years, older age, lower education level",
   "score": 12.230134010314941,
   "articlesIDs": [
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  },
  {
   "text": "ten-year oral contraceptive use from the age of 20 years",
   "score": 12.228986740112305,
   "articlesIDs": [
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  },
  {
   "text": "number of partners",
   "score": 12.226991653442383,
   "articlesIDs": [
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  },
  {
   "text": "women with mets",
   "score": 12.22172737121582,
   "articlesIDs": [
    "37109290"
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  },
  {
   "text": "multiple hpv 31/33/52 infections",
   "score": 12.218011856079102,
   "articlesIDs": [
    "37199394"
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  },
  {
   "text": "hpv positive females. hpv-16, 31, 33 and 58",
   "score": 12.212117195129395,
   "articlesIDs": [
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  },
  {
   "text": "t allele of pgf rs8019391",
   "score": 12.206005096435547,
   "articlesIDs": [
    "33109108"
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  },
  {
   "text": "homozygous a/a genotype of the ahr gene (rs2066853)",
   "score": 12.202468872070312,
   "articlesIDs": [
    "36376536"
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  },
  {
   "text": "tumor long diameter greater than or equal to 40 mm for cervical cancer",
   "score": 12.20208740234375,
   "articlesIDs": [
    "32147891"
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  },
  {
   "text": "cancer patients with no initial comorbidities",
   "score": 12.198051452636719,
   "articlesIDs": [
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  },
  {
   "text": "wlhiv",
   "score": 12.194080352783203,
   "articlesIDs": [
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  {
   "text": "hpv-16 (2.64-5.04) infections.\n\nconclusions:\nwhile hpv-16",
   "score": 12.193830490112305,
   "articlesIDs": [
    "34535177"
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  },
  {
   "text": "std-pericondylomotosis (p=0.029), std_hiv",
   "score": 12.192422866821289,
   "articlesIDs": [
    "33041448"
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  },
  {
   "text": "education level, type of vaginitis",
   "score": 12.191291809082031,
   "articlesIDs": [
    "34766625"
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  },
  {
   "text": "lack of screening, smoking, and infection with human papillomavirus (hpv)",
   "score": 12.186304092407227,
   "articlesIDs": [
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  },
  {
   "text": "co-infection with tv",
   "score": 12.18006706237793,
   "articlesIDs": [
    "32873233"
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  },
  {
   "text": "std-condylomotosis (p=0.035), std-pericondylomotosis (p=0.029), std_hiv",
   "score": 12.179830551147461,
   "articlesIDs": [
    "33041448"
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  },
  {
   "text": "age at first sexual intercourse \u003c 17 years",
   "score": 12.179597854614258,
   "articlesIDs": [
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  },
  {
   "text": "cd and excess body weight",
   "score": 12.179449081420898,
   "articlesIDs": [
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  },
  {
   "text": "syphilis",
   "score": 12.170891761779785,
   "articlesIDs": [
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  },
  {
   "text": "age greater than or equal to 60 years, clear cell carcinoma",
   "score": 12.168550491333008,
   "articlesIDs": [
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  {
   "text": "jiw",
   "score": 12.167449951171875,
   "articlesIDs": [
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  },
  {
   "text": "genital pain during sexual activity",
   "score": 12.158848762512207,
   "articlesIDs": [
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  {
   "text": "history of both sexual abuse and pelvic radiotherapy in women",
   "score": 12.15841293334961,
   "articlesIDs": [
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  },
  {
   "text": "depth of invasion\u003e10 mm",
   "score": 12.15745735168457,
   "articlesIDs": [
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  {
   "text": "lower education level, inadequate previous screening",
   "score": 12.151101112365723,
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  {
   "text": "lower education level, inadequate previous screening, bacterial vaginosis",
   "score": 12.151093482971191,
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  {
   "text": "a history of cancer (e = 6.05, p \u003c 0.01) or fibroids",
   "score": 12.144333839416504,
   "articlesIDs": [
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  },
  {
   "text": "chronic diseases (cd)",
   "score": 12.137924194335938,
   "articlesIDs": [
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  },
  {
   "text": "hpv type and hpv-16 variants",
   "score": 12.137596130371094,
   "articlesIDs": [
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  },
  {
   "text": "age of ≥50 years old, hpv 16 positive type",
   "score": 12.130011558532715,
   "articlesIDs": [
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  },
  {
   "text": "breastfeeding for 12 months or longer",
   "score": 12.129140853881836,
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  {
   "text": "lower education status, genital infections, early marriage age",
   "score": 12.124598503112793,
   "articlesIDs": [
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  {
   "text": "albumin\u003c3.5 g/dl",
   "score": 12.12310791015625,
   "articlesIDs": [
    "35241292"
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  },
  {
   "text": "hemoglobin \u003c12 g/dl, and nonsquamous cell histologic type.\n\nresults:\nlvsi",
   "score": 12.123090744018555,
   "articlesIDs": [
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  },
  {
   "text": "children and adolescents with perinatally acquired hiv",
   "score": 12.118807792663574,
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  {
   "text": "those who experienced cervical cancer",
   "score": 12.110057830810547,
   "articlesIDs": [
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  {
   "text": "family history of cancer, number of pregnancies",
   "score": 12.105209350585938,
   "articlesIDs": [
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  {
   "text": "age at first sexual intercourse \u003c 17 years ( = 0.009), past h/o sti",
   "score": 12.103799819946289,
   "articlesIDs": [
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  },
  {
   "text": "daily smoking ( = 0·0003) and syphilis",
   "score": 12.10287857055664,
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  {
   "text": "abnormal vaginal ph",
   "score": 12.101966857910156,
   "articlesIDs": [
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  {
   "text": "dysphagia (p = .04), albumin (alb) reduction",
   "score": 12.100410461425781,
   "articlesIDs": [
    "32846794"
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  },
  {
   "text": "lifetime sexual transmitted infections",
   "score": 12.096237182617188,
   "articlesIDs": [
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  },
  {
   "text": "every 1 kg/m increase in bmi",
   "score": 12.095438003540039,
   "articlesIDs": [
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  },
  {
   "text": "higher body mass index (\u003e23.92 kg/m)",
   "score": 12.08942985534668,
   "articlesIDs": [
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  },
  {
   "text": "tumour size and lymph-vascular space invasion (lvsi)",
   "score": 12.088400840759277,
   "articlesIDs": [
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  {
   "text": "lower socio-economic condition",
   "score": 12.085898399353027,
   "articlesIDs": [
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  {
   "text": "women with ≥2 sexual partners",
   "score": 12.078868865966797,
   "articlesIDs": [
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  {
   "text": "having a larger number of children",
   "score": 12.078444480895996,
   "articlesIDs": [
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  {
   "text": "a allele of the rs1800896 gene variant",
   "score": 12.063206672668457,
   "articlesIDs": [
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  {
   "text": "high-risk human papillomavirus (hrhpv)",
   "score": 12.059633255004883,
   "articlesIDs": [
    "33913528",
    "33826419",
    "33868241"
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  },
  {
   "text": "patients with cervical cancer who underwent arh",
   "score": 12.048994064331055,
   "articlesIDs": [
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  {
   "text": "having had three or more sexual partners",
   "score": 12.043007850646973,
   "articlesIDs": [
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  },
  {
   "text": "high-risk human papillomavirus (hr-hpv)",
   "score": 12.04287052154541,
   "articlesIDs": [
    "33378825",
    "35123443"
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  },
  {
   "text": "reproductive diseases, education level, and the number of live births",
   "score": 12.042152404785156,
   "articlesIDs": [
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  {
   "text": "having ≥3 lifetime sexual partners",
   "score": 12.040531158447266,
   "articlesIDs": [
    "32114194"
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  {
   "text": "history of alcohol consumption, marital status",
   "score": 12.039592742919922,
   "articlesIDs": [
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  {
   "text": "tumour size, lvsi and age",
   "score": 12.036144256591797,
   "articlesIDs": [
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  {
   "text": "acute survivorship stage",
   "score": 12.035170555114746,
   "articlesIDs": [
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  },
  {
   "text": "postoperative persistence of high hpv-dna levels within 12 months",
   "score": 12.034555435180664,
   "articlesIDs": [
    "36823536"
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  },
  {
   "text": "increased p16 expression and hpv16/18",
   "score": 12.033740997314453,
   "articlesIDs": [
    "33913528"
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  },
  {
   "text": "high-risk human papillomavirus (hpv) infection",
   "score": 12.027458190917969,
   "articlesIDs": [
    "34694000"
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  },
  {
   "text": "single hpv16 group",
   "score": 12.027050018310547,
   "articlesIDs": [
    "37212300"
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  },
  {
   "text": "having a larger number of children, regular menstrual function",
   "score": 12.02698040008545,
   "articlesIDs": [
    "33784210"
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  },
  {
   "text": "hpv16 or single hpv infection",
   "score": 12.021879196166992,
   "articlesIDs": [
    "31930525"
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  {
   "text": "increase of mtcn in cervical exfoliated cells",
   "score": 12.020753860473633,
   "articlesIDs": [
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  },
  {
   "text": "patients with sle",
   "score": 12.015129089355469,
   "articlesIDs": [
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  {
   "text": "women who have two or more lifetime sexual partners",
   "score": 12.012802124023438,
   "articlesIDs": [
    "37644484"
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  },
  {
   "text": "older age, uti",
   "score": 12.011247634887695,
   "articlesIDs": [
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  },
  {
   "text": "positive hpv18",
   "score": 12.0107421875,
   "articlesIDs": [
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  {
   "text": "reproductive disease history, and a history of alcohol consumption",
   "score": 12.007026672363281,
   "articlesIDs": [
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  },
  {
   "text": "other hrhpv (n = 590, 65.3%), hpv16 (n = 127, 14.1%), other hpv + hpv16",
   "score": 12.005912780761719,
   "articlesIDs": [
    "37179966"
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  {
   "text": "history of hyperlipidemias, family history of cancer",
   "score": 12.00165843963623,
   "articlesIDs": [
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  {
   "text": "women who self-identified as korean",
   "score": 11.997682571411133,
   "articlesIDs": [
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  {
   "text": "greater hydrometra volume",
   "score": 11.996454238891602,
   "articlesIDs": [
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  {
   "text": "lower socio-economic condition and higher parity",
   "score": 11.993721961975098,
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  {
   "text": "increased duration of catheterization",
   "score": 11.978180885314941,
   "articlesIDs": [
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  {
   "text": "marital status, reproductive diseases",
   "score": 11.971406936645508,
   "articlesIDs": [
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  {
   "text": "abnormal pre-cone ecc results, the cone method (leep vs ckc)",
   "score": 11.961575508117676,
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  {
   "text": "gstt1 null alleles",
   "score": 11.958334922790527,
   "articlesIDs": [
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  {
   "text": "genital infections, early marriage age and high parity",
   "score": 11.953272819519043,
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  {
   "text": "low level of education, lower socio-economic condition",
   "score": 11.949616432189941,
   "articlesIDs": [
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  {
   "text": "tumor long diameter greater than or equal to 60 mm for endometrial cancer",
   "score": 11.94836711883545,
   "articlesIDs": [
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  {
   "text": "carriers of tt genotype (p = 0.0388) and t allele",
   "score": 11.944541931152344,
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  {
   "text": "current alcohol consumption exceeding three drinks/day",
   "score": 11.940101623535156,
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  {
   "text": "cin1 or normal cervix positive for hrhpv",
   "score": 11.938230514526367,
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  {
   "text": "pre-operative albumin \u003c30 g/l",
   "score": 11.937915802001953,
   "articlesIDs": [
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  {
   "text": "v57 gy \u003c165 cm versus ≥165 cm",
   "score": 11.93442153930664,
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  {
   "text": "patients with persistent non-16/18 hpv infection",
   "score": 11.931477546691895,
   "articlesIDs": [
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  },
  {
   "text": "hpv18 and persistent hpv positivity",
   "score": 11.928997993469238,
   "articlesIDs": [
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  {
   "text": "metabolically healthy obesity",
   "score": 11.928053855895996,
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   "text": "pax8, clptm1l",
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   "text": "ivf and cc treatment",
   "score": 11.925050735473633,
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  {
   "text": "staphylococcus aureus bacteremia (sab)",
   "score": 11.925021171569824,
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  {
   "text": "genetic variants in the ctnnb1 gene",
   "score": 11.918047904968262,
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  {
   "text": "early sexual debut (13-16 years)",
   "score": 11.916952133178711,
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  {
   "text": "individuals with drug use disorders",
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  {
   "text": "those who experienced ovarian cancer",
   "score": 11.910013198852539,
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  {
   "text": "a history of both sexual abuse and pelvic radiotherapy in women",
   "score": 11.908490180969238,
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  {
   "text": "cancer type, cancer survivorship stage",
   "score": 11.905216217041016,
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  {
   "text": "low pre-operative albumin",
   "score": 11.90510368347168,
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  {
   "text": "presence of hr-hpv",
   "score": 11.902554512023926,
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  {
   "text": "other hpvs",
   "score": 11.899127960205078,
   "articlesIDs": [
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  {
   "text": "displaying previous lung metastasis and non-squamous histological types",
   "score": 11.895042419433594,
   "articlesIDs": [
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  {
   "text": "body mass index (bmi) of \u003c18.5 kg/m2 (aor = 3.83; 95% ci: 1.26, 8.76)",
   "score": 11.894968032836914,
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  {
   "text": "tnfaip2 rs710100 (or = 1.44, 95% ci =1.07-1.95, p = 0.018) polymorphisms",
   "score": 11.890425682067871,
   "articlesIDs": [
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  {
   "text": "disseminated cancer, longer operative time, and low pre-operative albumin",
   "score": 11.88701057434082,
   "articlesIDs": [
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  {
   "text": "number of sexual partners \u003e 1, ascus and above",
   "score": 11.881326675415039,
   "articlesIDs": [
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  {
   "text": "positive trichomonas vaginitis (tv)",
   "score": 11.880416870117188,
   "articlesIDs": [
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  {
   "text": "oestradiol",
   "score": 11.874788284301758,
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  {
   "text": "high bp",
   "score": 11.874227523803711,
   "articlesIDs": [
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  {
   "text": "maximal tumor diameter",
   "score": 11.869447708129883,
   "articlesIDs": [
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  {
   "text": "obese and morbidly obese women",
   "score": 11.868721008300781,
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  {
   "text": "pregnant wlwh",
   "score": 11.867061614990234,
   "articlesIDs": [
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  {
   "text": "ct, uup3, uup6 and mh infections",
   "score": 11.866264343261719,
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  {
   "text": "≥4 times frequency of vaginal sex in the past 1 month",
   "score": 11.862874984741211,
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  {
   "text": "patients with tumors \u003e2 cm in size",
   "score": 11.86207103729248,
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  },
  {
   "text": "tumour size 21-40 mm (or 2.14, 95% ci, 1.89-2.43) and depth of invasion\u003e10 mm",
   "score": 11.858652114868164,
   "articlesIDs": [
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  {
   "text": "sexually transmitted human papillomavirus (hpv)",
   "score": 11.858569145202637,
   "articlesIDs": [
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  },
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   "text": ", positive hpv at 1st follow-up",
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  {
   "text": "high risk hpv (hr-hpv)",
   "score": 8.646364212036133,
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  {
   "text": "the hoxb13 pgly84glu variant",
   "score": 8.638833999633789,
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  {
   "text": "women aged between 21-30 years",
   "score": 8.631871223449707,
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  {
   "text": "patients undergoing hysterectomy for pelvic organ prolapse",
   "score": 8.623432159423828,
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  {
   "text": "alterations of mitochondrial dna copy number (mtcn)",
   "score": 8.608603477478027,
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  {
   "text": "individuals 65-74 (or: 3.40, 95% ci: 1.52-7.62) and 75 or older",
   "score": 8.590316772460938,
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   "text": "women with sle",
   "score": 8.58083438873291,
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  {
   "text": "tanzanian wlwh",
   "score": 8.579158782958984,
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  },
  {
   "text": "africa (excluding north africa)",
   "score": 8.546914100646973,
   "articlesIDs": [
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  {
   "text": "high risk human papillomavirus (hrhpv) infection",
   "score": 8.546172142028809,
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  {
   "text": "evaluation by smaller (below 9000 slides processed per year) laboratories",
   "score": 8.538959503173828,
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  {
   "text": "tumor size \u003e 2 cm",
   "score": 8.537832260131836,
   "articlesIDs": [
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  }
 ]
}