risks-factors / H00031.json
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risk factors
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{
"id": "H00031",
"disease": {
"id": "H00031",
"names": [
"Breast cancer"
],
"dbLinks": {
"icd10": [
"C50"
],
"mesh": [
"D001943"
]
},
"category": "Cancer"
},
"riskFactors": [
{
"text": "higher breast density in women",
"score": 14.216422080993652,
"articlesIDs": [
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]
},
{
"text": "patients with asbestosis-related malignancies",
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]
},
{
"text": "hypertension, and obesity",
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},
{
"text": "diabetes mellitus, high baseline ggt levels, and significant hepatic fibrosis",
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},
{
"text": "hyperlipidemia, diabetes, smoking, and obesity",
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},
{
"text": "history of benign breast disease, and higher breast density in women",
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},
{
"text": "chlorinated alkanes",
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{
"text": "triglycerides (tg)",
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{
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{
"text": "chlorinated alkanes (or: 2.42, 95% ci: 1.23, 5.68), toluene",
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{
"text": "microcalcification and breast density",
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{
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{
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{
"text": "hypermethylation of the brca1 gene promoter",
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{
"text": "diesel exhaust (or = 1.23, 95% ci: 1.01-1.50) and benzo(a)pyrene exposure",
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{
"text": "previous benign breast surgery",
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{
"text": "higher ferritin, higher hs-crp",
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{
"text": "early menarche, menopausal status and previous benign breast surgery",
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{
"text": "hypermethylation of the brca1 gene promoter in women",
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{
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{
"text": "osteocalcin (oc)",
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{
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{
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{
"text": "hip fracture index, major osteoporotic fracture index, prolactin (prl)",
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"text": "obesity (25.8%), history of radiation",
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"text": "polymorphic t allele for vdr foki genotype (ct/tt)",
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{
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"text": "high bmi, second-hand smoke, and active smoking",
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"text": "individuals with multi-morbidity",
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"text": "consumption of solid oil, and using wood or animal dung as source of fuel",
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"text": "smoking history, high blood pressure, and body mass index (bmi)",
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{
"text": "cdh1rs3743674 polymorphism",
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"text": "women with breast trauma and miscarriage",
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"text": "patients diagnosed with diabetes at ages 30 to 49",
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"text": "high body mass index (bmi), high fasting plasma glucose (fpg)",
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{
"text": "exposure to bitumen fumes in the perinatal period",
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"text": "body mass index (bmi) and menopause",
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"text": "a/a genotype of apa1 (or = 6.094, 95%ci = 4.111 to 9.033) gene polymorphism",
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{
"text": "cardiovascular diseases",
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"text": "visceral metastasis",
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{
"text": "genetically predicted levels of testosterone, hdl cholesterol, and igf-1",
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"text": "using wood or animal dung as source of fuel, early menarche",
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"text": "cumulative dose, bmi, bsa, and hypocalcemia",
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{
"text": "body mass index ≥ 25.0 kg/m",
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{
"text": "high wind speed, and low vegetation cover",
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{
"text": "right-sided and hypofractionated radiotherapy containing rni",
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{
"text": "foki polymorphism of vdr gene and low circulating vitamin d levels",
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{
"text": "cardiovascular diseases, liver diseases",
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"text": "parity, breast self-examination, and bmi",
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"text": "major osteoporotic fracture index, prolactin (prl), and osteocalcin (oc)",
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"text": "cvd presence, high bmi, second-hand smoke, and active smoking",
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"text": "exposure to multiple aces",
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"text": "duration of aromatase inhibitor therapy, hip fracture index",
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"text": "serious air pollution, high wind speed, and low vegetation cover",
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{
"text": "tumor size \u003e 45 mm",
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"text": "family history of cardiovascular diseases, family history of breast cancer",
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"text": "old age (60 years old and more) (30.2%), obesity",
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{
"text": "deleterious brca1 mutation",
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"text": "hdl-c) (or 1.10, 95% ci 1.07-1.13, p = 6.10 × 10) and triglycerides (tg)",
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"text": "high fasting glucose and low hdl-c",
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"text": "age of onset of thelarche and menarche",
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"text": "fhbc in the mother or sister",
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"text": "high fasting plasma glucose (fpg), and a diet high in red meat",
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"text": "high body mass index, anemia, cardiovascular diseases",
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"text": "tobacco use",
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"text": "high il-6 and crp prechemotherapy",
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"text": "tgm3 deletion",
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"text": "risk factors such as diabetes, hypertension, and obesity",
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"text": "tamoxifen use",
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"text": "old age at ibc diagnosis",
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"text": "carriers of any mca",
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"text": "ethnicity (black vs. white), higher body mass index, higher weight increase",
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"text": "preoperative heparin use",
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"text": "hypertension, chronic obstructive pulmonary disease, and diabetes mellitus",
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"text": "higher neutrophil to lymphocyte ratio counts",
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"text": "presence of lvi and large tumour size",
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"text": "nuclear proliferation antigen index",
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"text": "younger age (less than 50 years old)",
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"text": "foreign-born chinese women",
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"text": "high tumour grades, presence of lvi and large tumour size",
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"text": "chronic pulmonary disease, mood disorder, and cerebrovascular disease",
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"text": "organic solvents with reactive metabolites",
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"text": "history of motion sickness",
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"text": "age-adjusted phenoage",
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"text": "old age at ibc diagnosis, low household income",
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"text": "axillary lymph node dissection (alnd)",
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"text": "history of breast trauma",
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"text": "initial exposure before 17 years old, longer asbestos exposure",
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"text": "low serum alb levels and increased ne counts",
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"text": "breast cancer exposure",
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"text": "later age of first childbirth",
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"text": "later age of first childbirth, and nulliparity/low parity",
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{
"text": "fhbc in both mother and sibling",
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{
"text": "body surface area (bsa)",
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{
"text": "increased number of dissected nodes",
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{
"text": "acetate",
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"text": "younger age (\u003c13 years) at menarche",
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{
"text": "non-red meat diet",
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{
"text": "each additional 1-year delay before the last full-term pregnancy",
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{
"text": "higher body mass index, higher weight increase, hypertension",
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{
"text": "male sex, chronic pulmonary disease",
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{
"text": "parous women",
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{
"text": "age \u003c 30 years old, age at menarche ≤ 11 years old",
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},
{
"text": "body mass index (bmi), family history of bc",
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{
"text": "alcohol consumption",
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