H00032.json

{
 "id": "H00032",
 "disease": {
  "id": "H00032",
  "names": [
   "Thyroid cancer"
  ],
  "dbLinks": {
   "icd10": [
    "C73"
   ],
   "mesh": [
    "D013964"
   ]
  },
  "category": "Cancer",
  "description": "Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma."
 },
 "riskFactors": [
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   "text": "hyperlipidemia",
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  {
   "text": "high-dose rai therapy",
   "score": 14.165721893310547,
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  {
   "text": "diabetes mellitus, high baseline ggt levels, and significant hepatic fibrosis",
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  {
   "text": "obesity, hyperlipidemia",
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  {
   "text": "thyroid cancer",
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  },
  {
   "text": "thyroid cancer and liver cancer",
   "score": 13.969573974609375,
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  },
  {
   "text": "hashimoto's thyroiditis",
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  {
   "text": "intact capsule (or = 2.54, =0.01), central lymph node metastasis",
   "score": 13.9608736038208,
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  {
   "text": "hyperlipidemia, thyroid cancer",
   "score": 13.947211265563965,
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  },
  {
   "text": "frequent diagnostic medical radiation exposure and high-dose rai therapy",
   "score": 13.942813873291016,
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  {
   "text": "hbme-1 expression",
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   "text": "hyperlipidemia, thyroid cancer and liver cancer",
   "score": 13.906919479370117,
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   "text": "chronic hbv or hcv infection",
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   "text": "thyroid dysfunction",
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   "text": "hyperlipidemia, previous cancers of the thyroid, stomach and liver",
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   "text": "central lymph node metastasis (or = 3.00, =0.02), and hashimoto's thyroiditis",
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   "text": "women with serous bots",
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   "text": "premenopausal",
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   "text": "gross ete and intermediate-risk cervical ln metastasis",
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   "text": "patients with dl or nafld",
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   "text": "early menarche age",
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   "text": "women with mucinous bots",
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   "text": "postpartum haemorrhage",
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   "text": "moderate to high levels of coumestrol intake",
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   "text": "tumor maximum diameter \u003e20 mm, multifocality",
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   "text": "multifocality, vascular invasion, a large number of central lymph nodes",
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   "text": "daily intake of more than 5 g of iodized salt",
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   "text": "patients with primary sjögren's syndrome(pss)",
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   "text": "adjacent to dorsal membranes",
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  {
   "text": "young age, large tumor diameter, multifocality, vascular invasion",
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   "text": "pediatric and early young adult patients with papillary thyroid carcinoma",
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   "text": "family history, obesity, and the unweighted and weighted prs",
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   "text": "high t stage (t3 + t4 stage)",
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   "text": "multifocality, capsular invasion and clnm",
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   "text": "number of positive lymph nodes, and low lymph node yield",
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   "text": "underweight body mass index (bmi)",
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   "text": "hispanic ethnicity",
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   "text": "patients with features suspicious of a follicular neoplasm (thy3f)",
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   "text": "multifocality of primary carcinoma, dln metastasis",
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   "text": "patients with dyslipidemia than in those without dyslipidemia",
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   "text": "lymphovascular invasion, number of positive lymph nodes",
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   "text": "tobacco use, viral infection, and iodine \u0026 vit-d deficiency",
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   "text": "enlarged lymph node present on imaging, nodule diameter",
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  {
   "text": "old age, male sex, and certain cancer types",
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   "text": "patients with older age",
   "score": 11.199746131896973,
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  {
   "text": "female gender, age older than 45 years, central lymph node dissection",
   "score": 11.198031425476074,
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  {
   "text": "tumor size \u003e5 mm",
   "score": 11.197074890136719,
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  {
   "text": "patients older than 55 years",
   "score": 11.195810317993164,
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  {
   "text": "patients with gete",
   "score": 11.175252914428711,
   "articlesIDs": [
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  {
   "text": "higher adii scores",
   "score": 11.1701078414917,
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  {
   "text": "larger number of birth with childhood brain",
   "score": 11.163739204406738,
   "articlesIDs": [
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  {
   "text": "patients with thyroid cancer appears to be high. dyslipidemia",
   "score": 11.162952423095703,
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  {
   "text": "a dietary pattern rich in sweetened beverages",
   "score": 11.157407760620117,
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   "text": "age less than 55 years old",
   "score": 11.144192695617676,
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  {
   "text": "female gender, younger age, and lower irradiation doses",
   "score": 11.13273811340332,
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   "text": "hypertension (htn)",
   "score": 11.127471923828125,
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  {
   "text": "presence of contralateral benign nodule, intra-tumoral calcification",
   "score": 11.118768692016602,
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   "text": "pasifika individuals",
   "score": 11.101067543029785,
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  {
   "text": "cancer site (p \u003c 0.001). compared to thyroid cancer, tb infection",
   "score": 11.097040176391602,
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  },
  {
   "text": "with moderate to high levels of coumestrol intake",
   "score": 11.096071243286133,
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  {
   "text": "allele 3434thr (c7)",
   "score": 11.09545612335205,
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  {
   "text": "the consumption of sweetened beverages",
   "score": 11.082904815673828,
   "articlesIDs": [
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  {
   "text": "allele 3434thr (c7), gc or cc genotype 31",
   "score": 11.081658363342285,
   "articlesIDs": [
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  },
  {
   "text": "metabolically unhealthy women, either normal weight or obese,",
   "score": 11.07856273651123,
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  },
  {
   "text": "a daily intake of more than 5 g of iodized salt",
   "score": 11.076766967773438,
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  {
   "text": "genetically shorter telomere length",
   "score": 11.071650505065918,
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  {
   "text": "shorter time interval between two cancers occurrences",
   "score": 11.061531066894531,
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  {
   "text": "consumption of iodized salts (or 2.06, 95% ci 1.21-3.51), tea",
   "score": 11.054912567138672,
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  {
   "text": "extrathyroidal extension, central lymph node metastasis",
   "score": 11.052490234375,
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  {
   "text": "loss of differentiation relative to well-differentiated ptc",
   "score": 11.051934242248535,
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  {
   "text": "low pod-1 versus preoperative ipth ratios",
   "score": 11.046168327331543,
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   "score": 11.045724868774414,
   "articlesIDs": [
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  {
   "text": "osa. thyroid carcinoma mortality data was unavailable.\n\nconclusions:\nosa",
   "score": 11.039234161376953,
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   "text": "a family history of thyroid disease",
   "score": 11.036815643310547,
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   "text": "pregnancy planning (or=2.97), and age ≥42.5 years",
   "score": 11.03276252746582,
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   "score": 11.03184986114502,
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   "text": "thyroid cancer (tc)",
   "score": 11.017857551574707,
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  {
   "text": "higher levels of tfqi, tshi, and tt4ri",
   "score": 11.010555267333984,
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  {
   "text": "thalassemia trait",
   "score": 11.006942749023438,
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   "text": "bmi of 30 kg/m and greater",
   "score": 11.002358436584473,
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  {
   "text": "male patients and those with a lower bmi",
   "score": 10.982246398925781,
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  {
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   "score": 10.930587768554688,
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   "text": "being 10 years or younger, t3 tumor stage, and n1b nodal stage",
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  {
   "text": "diagnosed with early-stage hnc",
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   "score": 10.842708587646484,
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  {
   "text": "central lymph node dissection, increased number of excised lymph nodes",
   "score": 10.831818580627441,
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  {
   "text": "25-hydroxyvitamin d [25(oh)d] and vitamin d binding protein (dbp)",
   "score": 10.831748008728027,
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   "text": "increased bmi, wc and hc",
   "score": 10.82740592956543,
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   "score": 10.815393447875977,
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   "text": "widely invasive ptc on ultrasound, and the presence of lymphadenopathy",
   "score": 10.813650131225586,
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   "text": "female ayas with breast, hematological, thyroid and melanoma cancer",
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   "score": 10.802154541015625,
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  {
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   "score": 10.749778747558594,
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   "score": 10.72404670715332,
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   "text": "patients with primary hyperparathyroidism (phpt)",
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   "text": "the concentration of (131)i aerosol in the nuclear medicine workplace",
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   "score": 10.700773239135742,
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   "text": "associated akt1 rs3803304 risk allele",
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  {
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   "score": 10.550898551940918,
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   "text": "\u003e5 pn1",
   "score": 10.543953895568848,
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   "text": "patients receiving radiotherapy to the thorax",
   "score": 10.53809928894043,
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   "score": 10.525491714477539,
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   "score": 10.516988754272461,
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   "text": "multilevel suspected llnm and loss of fatty hilum on ultrasound",
   "score": 10.50992202758789,
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   "text": "age \u003c42.5 years",
   "score": 10.498955726623535,
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   "score": 10.498191833496094,
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   "text": "central metastatic lymph nodes",
   "score": 10.474604606628418,
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   "text": "low-grade chronic inflammation, altered cytokine levels, insulin resistance",
   "score": 10.472105979919434,
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   "text": "older age and graft failure",
   "score": 10.47082233428955,
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   "text": "patients with nafld. diabetes mellitus",
   "score": 10.46980094909668,
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   "text": "ff genotype of foki",
   "score": 10.467941284179688,
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   "text": "thyroid cancer screening, thyroid dysfunction",
   "score": 10.462189674377441,
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   "text": "older age group",
   "score": 10.458794593811035,
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   "text": "lymphovascular invasion (\u003c0001) and extracapsular invasion",
   "score": 10.445613861083984,
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   "text": "number of foci",
   "score": 10.443934440612793,
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   "text": "5 μg/m increase of fine (diameter ≤2.5 μm) particulate matter concentrations",
   "score": 10.433891296386719,
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  {
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   "score": 10.413015365600586,
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  {
   "text": "bilateral salpingo-oophorectomy (bso)",
   "score": 10.401552200317383,
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   "text": "the middle-aged adults (adjusted shr, 2.09; rr, 1.76) and the older adults",
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  {
   "text": "diffuse-sclerosing variant ptc",
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   "text": ", women with serous bots",
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   "text": "obesity and t2dm",
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  {
   "text": "the tt genotype of akt1 rs1130233",
   "score": 9.656646728515625,
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  {
   "text": "high tc group",
   "score": 9.650339126586914,
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   "text": "disease course of sle (=4.25, 95% 1.79~10.01,\u003c0.001), hydroxychloroquine",
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   "text": "among patients over 65 years with obesity",
   "score": 9.636429786682129,
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   "text": "history of hypertension",
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   "score": 9.620119094848633,
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   "text": "acromegaly with cancer.\n\nconclusion:\nacromegaly",
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   "text": "contemporary levels of overweight and obesity",
   "score": 9.61647891998291,
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   "text": "high thyroid peroxidase antibody (tpoab)",
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   "score": 9.567557334899902,
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  {
   "text": "polychlorinated biphenyls and their metabolites",
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   "score": 9.54811954498291,
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   "text": "modified iodine intake, lifestyle-associated risk factors",
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   "text": "low hdl-c levels were",
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  {
   "text": "tsh levels were higher (p = 0.038). meanwhile, larger nodules (\u003e 4 cm)",
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  {
   "text": "proportion of the taqi tt genotype",
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  {
   "text": "patients with papillary thyroid carcinoma (ptc)",
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  {
   "text": "the hormonal change in women who had many children or abortions",
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   "text": "heart disease, hr 1.34; ci [1.25-1.44]; chronic lower respiratory disease",
   "score": 9.435400009155273,
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   "text": "there was a significant increase in bmi, wc and w/h ratio",
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   "text": "while a dietary pattern rich in sweetened beverages",
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   "text": "duration of acromegaly",
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   "text": "solid structure, hypoechogenicity, microcalcifications",
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   "text": "the formation of uterine fibroids (uf)",
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   "score": 9.347249984741211,
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   "text": "clnms \u003e 3",
   "score": 9.342369079589844,
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   "text": "tpoab+ and/or tgab+ patients",
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   "text": "younger age, lack of health insurance",
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   "text": "long disease course may be a risk factor for sle patients",
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   "text": "patients with hypothyroidism",
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   "text": "female, tg",
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   "text": "patients with systemic lupus erythematosus (sle)",
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   "text": "number of metastatic lymph nodes, and lnr \u003e 0.6",
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   "text": "the \u003c55-year-old group",
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   "text": "differentiated thyroid cancer (dtc) survivors",
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   "text": "tsnas in samples of deposited dust and residual fertilizer from the plant",
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   "text": "dose-dependent relationship was found between radioiodine treatment",
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   "text": "patients in the high tc group",
   "score": 8.833147048950195,
   "articlesIDs": [
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  },
  {
   "text": "mete and gete",
   "score": 8.822555541992188,
   "articlesIDs": [
    "32059626"
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  },
  {
   "text": "microcalcifications, taller than wide shape, irregular margins",
   "score": 8.819266319274902,
   "articlesIDs": [
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  },
  {
   "text": ", radiation exposure of the head",
   "score": 8.80368709564209,
   "articlesIDs": [
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  },
  {
   "text": "chinese uc patients",
   "score": 8.791696548461914,
   "articlesIDs": [
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  {
   "text": "patients with htn",
   "score": 8.787137031555176,
   "articlesIDs": [
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  },
  {
   "text": "increase of tc (=1.20, 95%: 1.06-1.34, =0.003), tg",
   "score": 8.784082412719727,
   "articlesIDs": [
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  },
  {
   "text": "middle thyroid nodules",
   "score": 8.771177291870117,
   "articlesIDs": [
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  },
  {
   "text": "congestive heart failure, cardiovascular accident",
   "score": 8.771129608154297,
   "articlesIDs": [
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  },
  {
   "text": "genetic syndromes",
   "score": 8.76211166381836,
   "articlesIDs": [
    "32682319"
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  },
  {
   "text": "higher maternal age at birth",
   "score": 8.73386001586914,
   "articlesIDs": [
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  {
   "text": "unmarried patients",
   "score": 8.727843284606934,
   "articlesIDs": [
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  {
   "text": "terf2, and rfwd3",
   "score": 8.72047233581543,
   "articlesIDs": [
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  },
  {
   "text": ", family history of thyroid diseases",
   "score": 8.71875,
   "articlesIDs": [
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  },
  {
   "text": "microcalcification (p = 0.037, or = 2.260, 95% ci: 1.051-4.860), shape",
   "score": 8.716495513916016,
   "articlesIDs": [
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  },
  {
   "text": "patients with multinodular goiter",
   "score": 8.713541984558105,
   "articlesIDs": [
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  },
  {
   "text": "progressively higher tsh",
   "score": 8.708511352539062,
   "articlesIDs": [
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  {
   "text": "gross extrathyroidal extension (ete) invading the strap muscles",
   "score": 8.702678680419922,
   "articlesIDs": [
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  },
  {
   "text": ". child height",
   "score": 8.69729232788086,
   "articlesIDs": [
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  },
  {
   "text": "csa",
   "score": 8.697237968444824,
   "articlesIDs": [
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   ]
  },
  {
   "text": "senp7, mob1b, carmil1, prrc2a, terf2, and rfwd3",
   "score": 8.697214126586914,
   "articlesIDs": [
    "32109421"
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  },
  {
   "text": "in men infected with hiv",
   "score": 8.678703308105469,
   "articlesIDs": [
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  {
   "text": "high in starchy foods and desserts",
   "score": 8.67868709564209,
   "articlesIDs": [
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  {
   "text": "male sex, large tumour size",
   "score": 8.66459846496582,
   "articlesIDs": [
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  {
   "text": "radioactive iodine (i)",
   "score": 8.65070629119873,
   "articlesIDs": [
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  },
  {
   "text": "population during the peak of coronavirus disease 2019 (covid-19)",
   "score": 8.62940502166748,
   "articlesIDs": [
    "37519348"
   ]
  },
  {
   "text": "cirrhosis, congestive heart failure, cardiovascular accident",
   "score": 8.62847900390625,
   "articlesIDs": [
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   ]
  },
  {
   "text": "lymph node stage n1b at diagnosis, and having five or more metastatic nodes,",
   "score": 8.6204833984375,
   "articlesIDs": [
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   ]
  },
  {
   "text": "ascending tg group, indicating that an ascending tg trend",
   "score": 8.605301856994629,
   "articlesIDs": [
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  },
  {
   "text": "tumors located in the inferior pole of the thyroid gland",
   "score": 8.602836608886719,
   "articlesIDs": [
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  {
   "text": "ldl",
   "score": 8.586389541625977,
   "articlesIDs": [
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   ]
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  {
   "text": "patients with htn, particularly males of age \u003e40",
   "score": 8.581348419189453,
   "articlesIDs": [
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  },
  {
   "text": "obesity was",
   "score": 8.580589294433594,
   "articlesIDs": [
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  },
  {
   "text": "congestive heart failure, cardiovascular accident, chronic kidney disease",
   "score": 8.57915210723877,
   "articlesIDs": [
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   ]
  },
  {
   "text": "cell phone use",
   "score": 8.578642845153809,
   "articlesIDs": [
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  },
  {
   "text": "early stg was 4.1 ng/ml",
   "score": 8.576763153076172,
   "articlesIDs": [
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  },
  {
   "text": "a patient with a fanca mutation",
   "score": 8.574251174926758,
   "articlesIDs": [
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   ]
  },
  {
   "text": "patient with celiac disease and thalassemia trait",
   "score": 8.570247650146484,
   "articlesIDs": [
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  },
  {
   "text": "serum tsh concentration",
   "score": 8.568018913269043,
   "articlesIDs": [
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  },
  {
   "text": "type 2 diabetes patients",
   "score": 8.561994552612305,
   "articlesIDs": [
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  },
  {
   "text": ", ebrt",
   "score": 8.560691833496094,
   "articlesIDs": [
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  },
  {
   "text": "fukushima dai-ichi nuclear power station (fdnps)",
   "score": 8.554132461547852,
   "articlesIDs": [
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   ]
  },
  {
   "text": "low hdl-c levels likely",
   "score": 8.553243637084961,
   "articlesIDs": [
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  },
  {
   "text": "overweight and obese",
   "score": 8.543164253234863,
   "articlesIDs": [
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  },
  {
   "text": "ldl (=1.21, 95%: 1.08-1.36, =0.001), ldl/hdl",
   "score": 8.5399808883667,
   "articlesIDs": [
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  },
  {
   "text": "patients with decreased thyroid hormone sensitivity",
   "score": 8.533620834350586,
   "articlesIDs": [
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  },
  {
   "text": "patients with primary sjögren's syndrome (pss)",
   "score": 8.526846885681152,
   "articlesIDs": [
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   ]
  },
  {
   "text": "among individuals with gstt1 and gstm1-deleted genotype",
   "score": 8.525699615478516,
   "articlesIDs": [
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 ]
}