H00035.json

{
 "id": "H00035",
 "disease": {
  "id": "H00035",
  "names": [
   "Ewing sarcoma",
   "SUPERGRP  Solid tumor [DS:H02421]",
   "Soft tissue sarcomas [DS:H02427]"
  ],
  "dbLinks": {
   "icd10": [
    "C41"
   ],
   "mesh": [
    "D012512"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
  {
   "text": "family history of cancer",
   "score": 13.90566635131836,
   "articlesIDs": [
    "19618453"
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  },
  {
   "text": "high birth weight",
   "score": 13.804396629333496,
   "articlesIDs": [
    "26371026"
   ]
  },
  {
   "text": "antineoplastic drugs, and ionizing radiation",
   "score": 13.760974884033203,
   "articlesIDs": [
    "16324620"
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  },
  {
   "text": "high fluoride exposure",
   "score": 13.731453895568848,
   "articlesIDs": [
    "19618453"
   ]
  },
  {
   "text": "hereditary retinoblastoma",
   "score": 13.686270713806152,
   "articlesIDs": [
    "16324620"
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  },
  {
   "text": "high level of lactic dehydrogenase, presence of fever",
   "score": 13.65241813659668,
   "articlesIDs": [
    "11295079"
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  },
  {
   "text": "hereditary retinoblastoma, li-fraumeni syndrome, antineoplastic drugs",
   "score": 13.637524604797363,
   "articlesIDs": [
    "16324620"
   ]
  },
  {
   "text": "fathers in farming",
   "score": 13.632137298583984,
   "articlesIDs": [
    "9839731"
   ]
  },
  {
   "text": "li-fraumeni syndrome, antineoplastic drugs, and ionizing radiation",
   "score": 13.62631607055664,
   "articlesIDs": [
    "16324620"
   ]
  },
  {
   "text": "mothers in teaching",
   "score": 13.584098815917969,
   "articlesIDs": [
    "9839731"
   ]
  },
  {
   "text": "chemical factors (antineoplastic drugs)",
   "score": 13.568985939025879,
   "articlesIDs": [
    "16324620"
   ]
  },
  {
   "text": "mothers in managerial and administrative work",
   "score": 13.534360885620117,
   "articlesIDs": [
    "9839731"
   ]
  },
  {
   "text": "age older than 12 years",
   "score": 13.503181457519531,
   "articlesIDs": [
    "11295079"
   ]
  },
  {
   "text": "pelvic location of the tumor, high level of lactic dehydrogenase",
   "score": 13.4935941696167,
   "articlesIDs": [
    "11295079"
   ]
  },
  {
   "text": "ctla-4 +49a/g variant",
   "score": 13.482755661010742,
   "articlesIDs": [
    "27644617"
   ]
  },
  {
   "text": "farming fathers at conception and/or pregnancy",
   "score": 13.442867279052734,
   "articlesIDs": [
    "12020108"
   ]
  },
  {
   "text": "advanced age, axial tumor location, and increasing tumor size",
   "score": 13.426874160766602,
   "articlesIDs": [
    "30412903"
   ]
  },
  {
   "text": "parental farming and residence on a farm, younger age at puberty",
   "score": 13.349847793579102,
   "articlesIDs": [
    "19618453"
   ]
  },
  {
   "text": "individuals with high birth weight",
   "score": 13.312390327453613,
   "articlesIDs": [
    "26371026"
   ]
  },
  {
   "text": "ctla-4 +49g\u003ea polymorphism",
   "score": 13.306999206542969,
   "articlesIDs": [
    "23900675",
    "27644617"
   ]
  },
  {
   "text": "histology types (osteosarcoma and ewing sarcoma)",
   "score": 13.303956031799316,
   "articlesIDs": [
    "31996232"
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  },
  {
   "text": "patients with osteosarcoma",
   "score": 13.244359970092773,
   "articlesIDs": [
    "21616236"
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  },
  {
   "text": "presence of hernias and ewing sarcoma; high fluoride exposure",
   "score": 13.158666610717773,
   "articlesIDs": [
    "19618453"
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  },
  {
   "text": "patients with osteosarcoma (or, 10.8), ewing sarcoma",
   "score": 13.133343696594238,
   "articlesIDs": [
    "21616236"
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  },
  {
   "text": "those with farming fathers at conception and/or pregnancy",
   "score": 13.09893798828125,
   "articlesIDs": [
    "12020108"
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  {
   "text": "children with fathers in social sciences",
   "score": 13.090429306030273,
   "articlesIDs": [
    "9839731"
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  },
  {
   "text": "areas of low population density",
   "score": 13.079561233520508,
   "articlesIDs": [
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  {
   "text": "treatment with radiation therapy",
   "score": 13.079063415527344,
   "articlesIDs": [
    "20634481"
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  },
  {
   "text": "patients with ewing sarcoma and larger tumors",
   "score": 13.078483581542969,
   "articlesIDs": [
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  },
  {
   "text": "areas of low population density and where more people owned cars",
   "score": 13.053253173828125,
   "articlesIDs": [
    "22738416"
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  },
  {
   "text": "patients with esft",
   "score": 13.007902145385742,
   "articlesIDs": [
    "18353632"
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  {
   "text": "younger age at puberty and family history of cancer",
   "score": 12.991361618041992,
   "articlesIDs": [
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  {
   "text": "earlier treatment era, diagnosis of hodgkin lymphoma",
   "score": 12.989133834838867,
   "articlesIDs": [
    "20634481"
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  {
   "text": "patients with osteosarcoma and lager tumors or higher tumor grade",
   "score": 12.982645988464355,
   "articlesIDs": [
    "31996232"
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  },
  {
   "text": "fathers in the social sciences",
   "score": 12.959922790527344,
   "articlesIDs": [
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  },
  {
   "text": "mothers in teaching (or = 3.1, 95% ci: 1.1-8.7) or farming",
   "score": 12.956686019897461,
   "articlesIDs": [
    "9839731"
   ]
  },
  {
   "text": "older age at diagnosis, earlier treatment era, diagnosis of hodgkin lymphoma",
   "score": 12.90051555633545,
   "articlesIDs": [
    "20634481"
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  },
  {
   "text": "parental occupation in farming",
   "score": 12.86473274230957,
   "articlesIDs": [
    "15704156"
   ]
  },
  {
   "text": "patients treated for sarcoma",
   "score": 12.864120483398438,
   "articlesIDs": [
    "29413281"
   ]
  },
  {
   "text": "a history of household pesticide extermination",
   "score": 12.741315841674805,
   "articlesIDs": [
    "15551353"
   ]
  },
  {
   "text": "doxorubicin dose per 10-mg/m increase",
   "score": 12.711628913879395,
   "articlesIDs": [
    "36875898"
   ]
  },
  {
   "text": "females in areas with lower deprivation levels",
   "score": 12.68758773803711,
   "articlesIDs": [
    "22738416"
   ]
  },
  {
   "text": "diagnosis of hodgkin lymphoma, and treatment with radiation therapy",
   "score": 12.679469108581543,
   "articlesIDs": [
    "20634481"
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  },
  {
   "text": "occupational exposure to herbicides, pesticides, or fertilizers",
   "score": 12.606064796447754,
   "articlesIDs": [
    "1311140"
   ]
  },
  {
   "text": "survivors of childhood osteosarcoma and ews",
   "score": 12.592020034790039,
   "articlesIDs": [
    "35059962"
   ]
  },
  {
   "text": "parental breast (sir 1.7) and prostate (sir 1.7) cancers",
   "score": 12.583426475524902,
   "articlesIDs": [
    "11809347"
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  },
  {
   "text": "those whose mothers handled pesticides and insecticides",
   "score": 12.57724380493164,
   "articlesIDs": [
    "12020108"
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  {
   "text": "childhood cancer survivors",
   "score": 12.51618766784668,
   "articlesIDs": [
    "37182536",
    "17557301"
   ]
  },
  {
   "text": "children with ewing's sarcoma family of tumours",
   "score": 12.501813888549805,
   "articlesIDs": [
    "15992697"
   ]
  },
  {
   "text": "patients with cvl dysfunction",
   "score": 12.501798629760742,
   "articlesIDs": [
    "16991135"
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  },
  {
   "text": "patients with hematopoietic and radiation-induced secondary malignancies",
   "score": 12.501143455505371,
   "articlesIDs": [
    "14612633"
   ]
  },
  {
   "text": "periconception and gestation periods",
   "score": 12.479602813720703,
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    "15704156"
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  {
   "text": "those \u003e24 years old",
   "score": 12.47851848602295,
   "articlesIDs": [
    "30412903"
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  },
  {
   "text": "higher levels of self-assessed exercise",
   "score": 12.470059394836426,
   "articlesIDs": [
    "12767069"
   ]
  },
  {
   "text": "black, asian, and white hispanic patients",
   "score": 12.460226058959961,
   "articlesIDs": [
    "20052725"
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  },
  {
   "text": "female sex, older age at diagnosis, earlier treatment era",
   "score": 12.445858001708984,
   "articlesIDs": [
    "20634481"
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  },
  {
   "text": "those who ever lived on a farm",
   "score": 12.429651260375977,
   "articlesIDs": [
    "12020108"
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  },
  {
   "text": "second-degree relatives",
   "score": 12.427223205566406,
   "articlesIDs": [
    "31670911"
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  {
   "text": "radiotherapy",
   "score": 12.41679573059082,
   "articlesIDs": [
    "9680933"
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  },
  {
   "text": "those with both parents having farmed",
   "score": 12.382959365844727,
   "articlesIDs": [
    "15704156"
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  {
   "text": "first-degree relatives",
   "score": 12.370122909545898,
   "articlesIDs": [
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  {
   "text": "gestational hypertension",
   "score": 12.34241771697998,
   "articlesIDs": [
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  {
   "text": "higher levels of non-car ownership",
   "score": 12.279226303100586,
   "articlesIDs": [
    "22738416"
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  },
  {
   "text": "ewing sarcoma (or, 3.05), or hepatocellular carcinoma",
   "score": 12.262503623962402,
   "articlesIDs": [
    "21616236"
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  {
   "text": "people with at least one copy of the minor allele of rs2857461",
   "score": 12.238967895507812,
   "articlesIDs": [
    "21793187"
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  {
   "text": "combination treatment with chemotherapy and radiation",
   "score": 12.227640151977539,
   "articlesIDs": [
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  {
   "text": "ewing sarcoma histology",
   "score": 12.199211120605469,
   "articlesIDs": [
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  {
   "text": "patients diagnosed at an older age",
   "score": 12.194672584533691,
   "articlesIDs": [
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  {
   "text": "product fabricating, assembling, and repairing",
   "score": 12.193917274475098,
   "articlesIDs": [
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  },
  {
   "text": "greater area-level population density and higher levels of non-car ownership",
   "score": 12.172022819519043,
   "articlesIDs": [
    "22738416"
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  },
  {
   "text": "size between 5 and 10 mm (or, 2.78); location within the right lower lobe",
   "score": 12.13473129272461,
   "articlesIDs": [
    "21616236"
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  },
  {
   "text": "the presence of hernias and ewing sarcoma; high fluoride exposure",
   "score": 12.133679389953613,
   "articlesIDs": [
    "19618453"
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  },
  {
   "text": "accelerated fetal growth",
   "score": 12.132670402526855,
   "articlesIDs": [
    "37335392"
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  {
   "text": "ewing sarcoma histology (hr 9.95, p \u003c .0001) and osteosarcoma histology",
   "score": 12.126673698425293,
   "articlesIDs": [
    "29413281"
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  {
   "text": "inguinal hernia",
   "score": 12.089231491088867,
   "articlesIDs": [
    "12767069"
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  },
  {
   "text": "tumor size over 8 cm",
   "score": 12.06655502319336,
   "articlesIDs": [
    "31681581"
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  {
   "text": "male patients, primary tumor site, tumor type and size",
   "score": 12.055068016052246,
   "articlesIDs": [
    "33553341"
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  {
   "text": "birthweight",
   "score": 12.050390243530273,
   "articlesIDs": [
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  },
  {
   "text": "sex, tumor site, type and size",
   "score": 12.026708602905273,
   "articlesIDs": [
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  {
   "text": "histology type (ewing sarcoma",
   "score": 11.997846603393555,
   "articlesIDs": [
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  },
  {
   "text": "patients diagnosed previously with hodgkin lymphoma (hl)",
   "score": 11.96669864654541,
   "articlesIDs": [
    "17557301"
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  },
  {
   "text": "long-term survivors of chondrosarcoma",
   "score": 11.964369773864746,
   "articlesIDs": [
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  {
   "text": "combination treatment with chemotherapy and radiation, earlier treatment era",
   "score": 11.942008972167969,
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  {
   "text": "case mothers who worked on farms at conception and/or pregnancy",
   "score": 11.922128677368164,
   "articlesIDs": [
    "12020108"
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  },
  {
   "text": "tumor in the axial or cranial bones",
   "score": 11.916252136230469,
   "articlesIDs": [
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  },
  {
   "text": "prior ingestion of poison or an overdose of medication",
   "score": 11.904603004455566,
   "articlesIDs": [
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  },
  {
   "text": "patients diagnosed previously with hodgkin lymphoma (hl), ewing sarcoma",
   "score": 11.890588760375977,
   "articlesIDs": [
    "17557301"
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  },
  {
   "text": "parental breast cancer",
   "score": 11.880477905273438,
   "articlesIDs": [
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  {
   "text": "patients with metastatic disease",
   "score": 11.859640121459961,
   "articlesIDs": [
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  {
   "text": "peripheral location (odds ratio [or], 9.1); size between 5 and 10 mm",
   "score": 11.853883743286133,
   "articlesIDs": [
    "21616236"
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  },
  {
   "text": "tumor in the axial or cranial bones, and a tumor size over 8 cm",
   "score": 11.83012580871582,
   "articlesIDs": [
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  {
   "text": "survivors of ewing sarcoma and astrocytoma",
   "score": 11.827945709228516,
   "articlesIDs": [
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  },
  {
   "text": "fathers who handled solvents and glues, and oils and greases",
   "score": 11.818719863891602,
   "articlesIDs": [
    "12020108"
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  },
  {
   "text": "higher grade (or = 5.197, 95% ci 3.328 to 8.117), histology type",
   "score": 11.814912796020508,
   "articlesIDs": [
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  },
  {
   "text": "receipt of radiation therapy",
   "score": 11.787647247314453,
   "articlesIDs": [
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  {
   "text": "diagnosis, combination treatment with chemotherapy and radiation",
   "score": 11.786783218383789,
   "articlesIDs": [
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  {
   "text": "those whose mothers had farmed",
   "score": 11.778465270996094,
   "articlesIDs": [
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  },
  {
   "text": "increase of 500 gram of birth weight",
   "score": 11.754312515258789,
   "articlesIDs": [
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  },
  {
   "text": "patients with metastatic disease and those with ewing sarcoma",
   "score": 11.71877670288086,
   "articlesIDs": [
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  },
  {
   "text": "patients with cvl-dysfunction",
   "score": 11.70146369934082,
   "articlesIDs": [
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  },
  {
   "text": "number of cigarettes the mother smoked per day during the pregnancy",
   "score": 11.68922233581543,
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  },
  {
   "text": "higher maternal education",
   "score": 11.642120361328125,
   "articlesIDs": [
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  },
  {
   "text": "aya patients",
   "score": 11.579267501831055,
   "articlesIDs": [
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   ]
  },
  {
   "text": "distant disease (hr 2.67, p=.004), male gender",
   "score": 11.571427345275879,
   "articlesIDs": [
    "29413281"
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  },
  {
   "text": "organic dusts encountered when working on a farm",
   "score": 11.569536209106445,
   "articlesIDs": [
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  },
  {
   "text": "distant metastasis",
   "score": 11.513221740722656,
   "articlesIDs": [
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  },
  {
   "text": "third-degree relatives",
   "score": 11.478222846984863,
   "articlesIDs": [
    "31670911"
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  },
  {
   "text": "receipt of radiation therapy (hazard ratio [hr] 1.67, p=.02), distant disease",
   "score": 11.456048011779785,
   "articlesIDs": [
    "29413281"
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  },
  {
   "text": "children's diseases in their history, which increased the risk were measles",
   "score": 11.410066604614258,
   "articlesIDs": [
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  },
  {
   "text": "an interval between onset of symptoms and diagnosis less than 3 months",
   "score": 11.348506927490234,
   "articlesIDs": [
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  },
  {
   "text": "persons whose initial treatment for childhood cancer included radiotherapy",
   "score": 11.312687873840332,
   "articlesIDs": [
    "17557301"
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  },
  {
   "text": "accumulation of ≥4 grade 3-4 chronic conditions",
   "score": 11.284300804138184,
   "articlesIDs": [
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  },
  {
   "text": "and age older than 12 years",
   "score": 11.224720001220703,
   "articlesIDs": [
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  {
   "text": "children whose fathers had worked on farms",
   "score": 11.214729309082031,
   "articlesIDs": [
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  },
  {
   "text": "ewing sarcoma, primitive neuroectodermal tumor, or retinoblastoma",
   "score": 11.207802772521973,
   "articlesIDs": [
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  },
  {
   "text": "survivors of aya bone and soft tissue sarcoma",
   "score": 11.186967849731445,
   "articlesIDs": [
    "24752471"
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  },
  {
   "text": "mumps",
   "score": 11.170324325561523,
   "articlesIDs": [
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  },
  {
   "text": "hearing impairment",
   "score": 11.133450508117676,
   "articlesIDs": [
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  },
  {
   "text": "osteosarcoma and ewing sarcoma survivors",
   "score": 11.098255157470703,
   "articlesIDs": [
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  },
  {
   "text": "those with at least one parent having farmed",
   "score": 11.097894668579102,
   "articlesIDs": [
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  },
  {
   "text": "patients with an age between 18 and 59 years old",
   "score": 11.088186264038086,
   "articlesIDs": [
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  },
  {
   "text": "age at diagnosis (hr: 1.23; 95% ci: 1.06-1.43) per 5-year increase",
   "score": 11.069171905517578,
   "articlesIDs": [
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  {
   "text": "long-term survivors of childhood es",
   "score": 11.054519653320312,
   "articlesIDs": [
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  },
  {
   "text": "increased health-care usage",
   "score": 11.038890838623047,
   "articlesIDs": [
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  {
   "text": "poor health status",
   "score": 11.014082908630371,
   "articlesIDs": [
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  {
   "text": "earlier treatment era, and fewer years since diagnosis",
   "score": 10.969718933105469,
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  {
   "text": "young age",
   "score": 10.946239471435547,
   "articlesIDs": [
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  {
   "text": "cytomegalovirus (cmv)",
   "score": 10.882120132446289,
   "articlesIDs": [
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  },
  {
   "text": "increased health-care usage and poor health status",
   "score": 10.852391242980957,
   "articlesIDs": [
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  },
  {
   "text": "fathers had occupational exposure to herbicides, pesticides, or fertilizers",
   "score": 10.79196834564209,
   "articlesIDs": [
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  {
   "text": "an increase of 500 gram of birth weight",
   "score": 10.773069381713867,
   "articlesIDs": [
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  {
   "text": "among children with fathers in social sciences",
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}