H00040.json

{
 "id": "H00040",
 "disease": {
  "id": "H00040",
  "names": [
   "Squamous cell carcinoma"
  ],
  "dbLinks": {
   "icd10": [
    "C44"
   ],
   "mesh": [
    "D002294"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
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   "text": "alcohol consumption",
   "score": 14.083612442016602,
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  {
   "text": "alcohol drinking",
   "score": 14.019291877746582,
   "articlesIDs": [
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  {
   "text": "family history of hnc, low bmi and several occupations and industries",
   "score": 14.016481399536133,
   "articlesIDs": [
    "34592954"
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  },
  {
   "text": "alcohol drinking, high-risk hpv",
   "score": 14.015948295593262,
   "articlesIDs": [
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  },
  {
   "text": "helicobacter pylori",
   "score": 13.977280616760254,
   "articlesIDs": [
    "35155235"
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  {
   "text": "alcohol drinking, high-risk hpv, family history of hnc, low bmi",
   "score": 13.961711883544922,
   "articlesIDs": [
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  {
   "text": "diabetes mellitus",
   "score": 13.94242000579834,
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  {
   "text": "tobacco smoking, alcohol drinking",
   "score": 13.929483413696289,
   "articlesIDs": [
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  {
   "text": "tobacco smoking, alcohol drinking, high-risk hpv",
   "score": 13.926139831542969,
   "articlesIDs": [
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  },
  {
   "text": "consumption of all four ingredients together, duration of smoking",
   "score": 13.923654556274414,
   "articlesIDs": [
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  {
   "text": "patients with a hnscc",
   "score": 13.92140007019043,
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    "37149128"
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  },
  {
   "text": "slow-metabolizing alcohol dehydrogenase 1b",
   "score": 13.920178413391113,
   "articlesIDs": [
    "37370215"
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  },
  {
   "text": "patients with mild-moderate dysplasia",
   "score": 13.914402961730957,
   "articlesIDs": [
    "35623589"
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  },
  {
   "text": "consumption of betel quid containing tobacco (smokeless tobacco)",
   "score": 13.888022422790527,
   "articlesIDs": [
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  },
  {
   "text": "smokers (or = 1.79; 95% ci [1.02, 3.03]), alcohol consumers",
   "score": 13.886528015136719,
   "articlesIDs": [
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  {
   "text": "intraoperative bleeding",
   "score": 13.877250671386719,
   "articlesIDs": [
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  {
   "text": "hpv16/18 and multiple hr-hpv infection",
   "score": 13.872180938720703,
   "articlesIDs": [
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  {
   "text": "advanced clinical stage, intraoperative bleeding",
   "score": 13.869762420654297,
   "articlesIDs": [
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  {
   "text": "low capillary permeability",
   "score": 13.854249954223633,
   "articlesIDs": [
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  {
   "text": "hypertension, diabetes, carotid artery stenosis",
   "score": 13.848917007446289,
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   "text": "use of smokeless tobacco",
   "score": 13.843303680419922,
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  {
   "text": "hemoglobin, albumin, and total t lymphocyte count",
   "score": 13.837798118591309,
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  {
   "text": "patients with lgin",
   "score": 13.837005615234375,
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   "text": "consumption of locally-made illicit liquor",
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   "text": "poorly differentiated grade, and higher t/n stage",
   "score": 13.813257217407227,
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  {
   "text": "hnscc patients, especially drinkers with an alcohol flushing response",
   "score": 13.81025505065918,
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  {
   "text": "extreme obesity and being underweight",
   "score": 13.801905632019043,
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  {
   "text": "diabetes mellitus, tumour location",
   "score": 13.790572166442871,
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   "text": "smoking index, diabetes mellitus",
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  {
   "text": "even-chain unsaturated fatty acid (ec-ufa) pattern",
   "score": 13.788049697875977,
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  {
   "text": "areca nut was chewed by 47.61% participants ( = 10), smoking tobacco",
   "score": 13.778486251831055,
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  {
   "text": "blue/light eye colors",
   "score": 13.763688087463379,
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   "text": "consumption of locally-made illicit liquor and current consumers of alcohol",
   "score": 13.762548446655273,
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   "text": "use of smokeless tobacco, consumption of all four ingredients together",
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   "text": "consuming alcohol",
   "score": 13.754865646362305,
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   "text": "chewing tobacco by 38.09% ( = 8), and consuming alcohol",
   "score": 13.754539489746094,
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   "text": "patients with immunosuppression",
   "score": 13.751148223876953,
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  {
   "text": "advanced age, smoking index, diabetes mellitus",
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   "text": "tumour location, advanced clinical stage, intraoperative bleeding",
   "score": 13.741782188415527,
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  {
   "text": "hypertension, diabetes, carotid artery stenosis, coronary artery disease",
   "score": 13.74015998840332,
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  {
   "text": "smoking tobacco by 76.19% ( = 16), chewing tobacco",
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   "text": "longer duration of alcohol use",
   "score": 13.7177734375,
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   "text": "duration of smoking, the number of cigarettes smoked per day",
   "score": 13.70495891571045,
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  {
   "text": "saturated fatty acid (sfa) pattern",
   "score": 13.680073738098145,
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  {
   "text": "red olp lesions (or = 3.52; 95% ci [2.20, 5.64]), smokers",
   "score": 13.670792579650879,
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  {
   "text": "patients with copd",
   "score": 13.660529136657715,
   "articlesIDs": [
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  {
   "text": "diabetes mellitus, tumour location, advanced clinical stage",
   "score": 13.651298522949219,
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   "text": "combined consumption of betel quid and smoking",
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  {
   "text": "n-3 long-chain polyunsaturated fatty acid (n-3 lc-pufa) pattern",
   "score": 13.643852233886719,
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  {
   "text": "smokers, alcohol consumers, and hcv-positive patients",
   "score": 13.6419677734375,
   "articlesIDs": [
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  {
   "text": "positive glandular involvement, hpv16/18 and multiple hr-hpv infection",
   "score": 13.641874313354492,
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  {
   "text": "smoking index, diabetes mellitus, tumour location",
   "score": 13.637224197387695,
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   "text": "betel quid chewing",
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  {
   "text": "deep 1/3 interstitial infiltration",
   "score": 13.624961853027344,
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   "text": "red olp lesions, smokers",
   "score": 13.62088394165039,
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  {
   "text": "history of alcohol consumption",
   "score": 13.618612289428711,
   "articlesIDs": [
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  {
   "text": "salty diet, and positive family history of cancer",
   "score": 13.614489555358887,
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   "text": "poor pathological differentiation, primary chemoradiotherapy and radiotherapy",
   "score": 13.608240127563477,
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   "text": "older age, a history of alcohol consumption",
   "score": 13.596155166625977,
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   "text": "hpv16 seropositivity",
   "score": 13.58547306060791,
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   "text": "red olp lesions, smokers, alcohol consumers, and hcv-positive patients",
   "score": 13.583505630493164,
   "articlesIDs": [
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  {
   "text": "advanced age, non-asian/pacific islander, non-squamous cell carcinoma",
   "score": 13.580358505249023,
   "articlesIDs": [
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  {
   "text": "smoking, alcohol consumption",
   "score": 13.576322555541992,
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  {
   "text": "high ki67 li of hnscc tissue",
   "score": 13.56507682800293,
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  {
   "text": "petroleum industry workers (or=3.2; 95% ci: 1.1 to 9.8), female farmers",
   "score": 13.559739112854004,
   "articlesIDs": [
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  {
   "text": "smoking, alcohol consumption, betel quid chewing",
   "score": 13.553376197814941,
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  {
   "text": "aldh2*1/*2",
   "score": 13.547401428222656,
   "articlesIDs": [
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  {
   "text": "areca nut and tobacco chewing along with alcohol consumption",
   "score": 13.544740676879883,
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   "text": "hazel/green/medium eye colors",
   "score": 13.54301643371582,
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   "text": "adh1b*1/*1",
   "score": 13.537548065185547,
   "articlesIDs": [
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  {
   "text": "positive margin, positive glandular involvement, hpv16/18",
   "score": 13.537008285522461,
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   "text": "individuals who had consumed alcohol for more than 20 years",
   "score": 13.526873588562012,
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  {
   "text": "sleep \u003e9 h/day (hr=2.05, 95%ci: 1.18, 3.57) and sometimes daytime napping",
   "score": 13.52266788482666,
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  {
   "text": "history of alcohol consumption, a high charlson comorbidity index score",
   "score": 13.52215576171875,
   "articlesIDs": [
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  {
   "text": "adh1b*1/*1, aldh2*1/*2",
   "score": 13.514135360717773,
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  {
   "text": "clumping clay cat litter and flea collar use",
   "score": 13.506805419921875,
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  {
   "text": "high tnm stage (iii and iv)",
   "score": 13.504983901977539,
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  {
   "text": "pest infestation of grain and/or nuts",
   "score": 13.499327659606934,
   "articlesIDs": [
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  {
   "text": "smoking, alcohol use, hepatitis c infection and erosive or atrophic subtypes",
   "score": 13.47581672668457,
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  {
   "text": "nodal involvement",
   "score": 13.4755859375,
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  {
   "text": "hpv type (hpv16/18)",
   "score": 13.47203540802002,
   "articlesIDs": [
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  {
   "text": "poor oral hygiene, and loss of teeth",
   "score": 13.471199035644531,
   "articlesIDs": [
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  {
   "text": "cigarette usage and alcohol abuse",
   "score": 13.464683532714844,
   "articlesIDs": [
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  {
   "text": "high sunburn frequency throughout life",
   "score": 13.452314376831055,
   "articlesIDs": [
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  {
   "text": "human papilloma virus (hpv) infection, mustard gas",
   "score": 13.450372695922852,
   "articlesIDs": [
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  {
   "text": "cigarette smoking, human papilloma virus (hpv) infection, mustard gas",
   "score": 13.424978256225586,
   "articlesIDs": [
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  {
   "text": "high charlson comorbidity index score, a high tnm stage (iii and iv)",
   "score": 13.422849655151367,
   "articlesIDs": [
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  {
   "text": "non-squamous cell carcinoma, poorly differentiated grade",
   "score": 13.412535667419434,
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  {
   "text": "previous history of oral leukoplakia or dysplasia",
   "score": 13.386364936828613,
   "articlesIDs": [
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  },
  {
   "text": "chronic inflammation, lichen sclerosis",
   "score": 13.383462905883789,
   "articlesIDs": [
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  },
  {
   "text": "exposure to ultraviolet radiation",
   "score": 13.374285697937012,
   "articlesIDs": [
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  {
   "text": "oral-snuff users, hot tea drinkers",
   "score": 13.373323440551758,
   "articlesIDs": [
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  {
   "text": "high tumor stage (iii and iv), nodal involvement",
   "score": 13.372888565063477,
   "articlesIDs": [
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  {
   "text": "nodal involvement, poor pathological differentiation",
   "score": 13.370390892028809,
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  {
   "text": "low body mass index (bmi)",
   "score": 13.368896484375,
   "articlesIDs": [
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  {
   "text": "menopausal status, hpv type (hpv16/18)",
   "score": 13.35594367980957,
   "articlesIDs": [
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  {
   "text": "hpv16/18 infection",
   "score": 13.355314254760742,
   "articlesIDs": [
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  {
   "text": "drinking well and surface water, salty diet",
   "score": 13.354940414428711,
   "articlesIDs": [
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  {
   "text": "alcohol consumption (aor, 1.6; 95%ci, 1.1-2.2), and hpv16 seropositivity",
   "score": 13.347846984863281,
   "articlesIDs": [
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  {
   "text": "uneducated people, oral-snuff users, hot tea drinkers",
   "score": 13.342597961425781,
   "articlesIDs": [
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  {
   "text": "secondhand tobacco smoke exposure, and pest infestation of grain and/or nuts",
   "score": 13.339627265930176,
   "articlesIDs": [
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  },
  {
   "text": "diabetes history, deceased donor, cyclosporin, and mtor inhibitor use",
   "score": 13.332254409790039,
   "articlesIDs": [
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  {
   "text": "alcohol and hnscc location",
   "score": 13.326286315917969,
   "articlesIDs": [
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  {
   "text": "periodontal disease, poor oral hygiene, and loss of teeth",
   "score": 13.323722839355469,
   "articlesIDs": [
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  {
   "text": "co-infected with hpv16/18",
   "score": 13.322010040283203,
   "articlesIDs": [
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  {
   "text": "cmi",
   "score": 13.312671661376953,
   "articlesIDs": [
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  {
   "text": "tobacco use, obesity, poor hygiene, exposure to ultraviolet radiation",
   "score": 13.310881614685059,
   "articlesIDs": [
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  {
   "text": "exposure to ultraviolet radiation, history of sexually transmitted diseases",
   "score": 13.308815002441406,
   "articlesIDs": [
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  {
   "text": "human papillomavirus (hpv) infection",
   "score": 13.296061515808105,
   "articlesIDs": [
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    "37528497",
    "35930449",
    "35274916",
    "34695758"
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  {
   "text": "low socio-economic status",
   "score": 13.295395851135254,
   "articlesIDs": [
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  {
   "text": "qulurtoroosh",
   "score": 13.292658805847168,
   "articlesIDs": [
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  {
   "text": "oral-snuff users, hot tea drinkers, fewer fresh fruit consumers",
   "score": 13.287105560302734,
   "articlesIDs": [
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  {
   "text": "advanced age (\u003e35 years), menopausal status, hpv type (hpv16/18)",
   "score": 13.286652565002441,
   "articlesIDs": [
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  {
   "text": "patients with mpm",
   "score": 13.283592224121094,
   "articlesIDs": [
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  {
   "text": "patients with head and neck squamous cell carcinoma (hnscc)",
   "score": 13.280801773071289,
   "articlesIDs": [
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    "37149128"
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  {
   "text": "alcohol-drinker patients",
   "score": 13.280281066894531,
   "articlesIDs": [
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  {
   "text": "high alcohol consumption",
   "score": 13.271345138549805,
   "articlesIDs": [
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  {
   "text": "caucasian race, pretransplant malignancy",
   "score": 13.26446533203125,
   "articlesIDs": [
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  {
   "text": "betel quid chewing habit",
   "score": 13.262723922729492,
   "articlesIDs": [
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  {
   "text": "heavy ex-smoker patients, alcohol-drinker patients",
   "score": 13.260040283203125,
   "articlesIDs": [
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  {
   "text": "port treatment",
   "score": 13.258481979370117,
   "articlesIDs": [
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  {
   "text": "low body mass index (bmi), low socio-economic status",
   "score": 13.258410453796387,
   "articlesIDs": [
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  },
  {
   "text": "visceral pleural invasion (vpi) and tumor spread through air spaces (stas)",
   "score": 13.248088836669922,
   "articlesIDs": [
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  {
   "text": "environmental tobacco smoke",
   "score": 13.224634170532227,
   "articlesIDs": [
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   "text": "psychological stress",
   "score": 13.221184730529785,
   "articlesIDs": [
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  {
   "text": "consumption of dark tea, very hot beverage and qulurtoroosh",
   "score": 13.21379280090332,
   "articlesIDs": [
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  },
  {
   "text": "patients with periodontal disease",
   "score": 13.21151351928711,
   "articlesIDs": [
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   "score": 13.135029792785645,
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   "score": 12.239452362060547,
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   "text": "female sex had significant effects on the mt of ol.\n\nconclusion:\nol",
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   "score": 12.105792999267578,
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  {
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   "score": 12.105676651000977,
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   "score": 12.10130500793457,
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   "score": 12.079720497131348,
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   "score": 12.052543640136719,
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   "score": 12.048809051513672,
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  {
   "text": "old age, genetic predisposition, immunosuppression",
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  {
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   "score": 12.04272747039795,
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  {
   "text": "multifocal lesions of ol (p = 0.047), and candida infection",
   "score": 12.032499313354492,
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  {
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   "score": 12.024388313293457,
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  {
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  {
   "text": "high level of aminomalonic acid",
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   "score": 11.967827796936035,
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   "score": 11.964320182800293,
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   "score": 11.960236549377441,
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   "score": 11.954557418823242,
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   "score": 11.86563491821289,
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  {
   "text": "patients with a cancer history in one of their siblings",
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   "text": "tumors of the hard palate (hr 4.3, 95% ci 1.2-16.1), upper alveolus",
   "score": 11.81115436553955,
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   "text": "male sex (or, 2.59; 95% ci, 1.70-3.96), perineural/lymphovascular invasion",
   "score": 11.791667938232422,
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   "text": "lymphovascular invasion (lvi), depth of invasion (di)",
   "score": 11.788711547851562,
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   "text": "being of a male gender, an aggressive tumor subtype",
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   "score": 11.761800765991211,
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   "text": "crs of 12 to 20 points and \u003e20 points",
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  {
   "text": "age, expression level of ki 67 and her-2, molecular typing",
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   "score": 11.741539001464844,
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   "text": "postoperative persistence of high hpv-dna levels within 12 months",
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   "text": "actinic keratosis (ak)",
   "score": 11.739459991455078,
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  {
   "text": "districts with high rates of daily smoking",
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   "text": "hazel/green/medium and blue/light colors",
   "score": 11.736200332641602,
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   "score": 11.735003471374512,
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   "score": 11.734009742736816,
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   "text": "history of actinic keratosis in both data sets, and male sex",
   "score": 11.733915328979492,
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  {
   "text": "high-grade tumor budding",
   "score": 11.733492851257324,
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   "text": "social behavior factors, immunosuppression, occupational exposure",
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   "text": "older age, advanced tumor-node-metastasis (tnm) stage",
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   "text": "patients receiving hnscc surgery. patients receiving radiation therapy",
   "score": 11.691027641296387,
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   "text": "lymphovascular invasion (lvi), depth of invasion (di), tumour size (ts)",
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   "text": "desmoplasia (hr 15.39; p \u0026lt; 0.01) and bone invasion",
   "score": 11.680194854736328,
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   "text": "history of multiple tumors at diagnosis, immunosuppression, and male sex",
   "score": 11.66943359375,
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   "text": "variant genotypes of cyps (1a1 or 1b1 or 2e1)",
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   "text": "high levels of selenium with lower levels of vitamin e",
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   "text": "patients with advanced tnm stage",
   "score": 11.667388916015625,
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   "text": "age, history of skin cancer, and history of actinic keratosis",
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  {
   "text": "cutaneous squamous cell carcinoma (cscc)",
   "score": 11.652006149291992,
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  {
   "text": "undifferentiated carcinoma",
   "score": 11.649421691894531,
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   "text": "gpv carriers. similar associations were observed with p16 alteration",
   "score": 11.647186279296875,
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  {
   "text": "the ab type of intrapapillary capillary loop (ipcl)",
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   "text": "older at the diagnosis, white and having a higher histological grade",
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   "score": 11.632914543151855,
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   "text": "moderate differentiation grade and an invasion depth ≥ 2 mm",
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   "text": "smokers, patients with chronic obstructive pulmonary disease",
   "score": 11.63012981414795,
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   "text": "acetaldehyde-to-ethanol ratio of \u003e 28.1",
   "score": 11.628947257995605,
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   "text": "gastroesophageal reflux disease (gerd)",
   "score": 11.627766609191895,
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   "text": "advanced age, and extended disease duration. alcohol intake and smoking",
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   "text": "participants with hazel/green/medium eye colors",
   "score": 11.627473831176758,
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  {
   "text": "familial atypical multiple mole-melanoma syndrome",
   "score": 11.601883888244629,
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   "text": "epstein-barr virus）, lifestyle （smoking, drinking, diet, chewing betel nut）",
   "score": 11.601285934448242,
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   "text": "subglottic tumors (odds ratio [or], 3.74; 95% ci, 1.75-7.99), t4 stage tumors",
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