H00043.json

{
 "id": "H00043",
 "disease": {
  "id": "H00043",
  "names": [
   "Neuroblastoma"
  ],
  "dbLinks": {
   "icd10": [
    "C38",
    "C47",
    "C48",
    "C72",
    "C74",
    "C76"
   ],
   "mesh": [
    "D009447"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
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  {
   "text": "patients with longer duration of catheter insertion",
   "score": 10.800325393676758,
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   "text": "art use was highest among children with osteosarcoma",
   "score": 10.796283721923828,
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   "text": "age \u003e 1 yr with stage 4 disease at diagnosis",
   "score": 10.790534973144531,
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   "text": "presence of three risk genotypes",
   "score": 10.788755416870117,
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   "text": "maternal exposure to hair dyes and aromatic hydrocarbons",
   "score": 10.762723922729492,
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   "text": "mother had pre-eclampsia",
   "score": 10.752266883850098,
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   "text": "dibenz(a,h)anthracene. hexavalent chromium",
   "score": 10.741706848144531,
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   "score": 10.74014949798584,
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   "text": "mycn (e beta = 4.26), for stage 4 by mycn",
   "score": 10.726282119750977,
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   "text": "a118g polymorphism of exon1 of human oprm1 gene (hoprm1),",
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   "score": 10.679243087768555,
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   "score": 10.669759750366211,
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   "score": 10.664749145507812,
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  {
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   "score": 10.64181900024414,
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   "score": 10.60737419128418,
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   "score": 10.605086326599121,
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   "score": 10.595564842224121,
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   "score": 10.5787992477417,
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   "text": "german measles) (or = 0.60, 95% ci: 0.39, 0.93), and allergies",
   "score": 10.57760238647461,
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   "score": 10.548245429992676,
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   "text": "diagnosis of acute or chronic leukemia",
   "score": 10.54585075378418,
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   "score": 10.515562057495117,
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   "score": 10.511775970458984,
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   "score": 10.51146411895752,
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   "score": 10.49433708190918,
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   "score": 10.493531227111816,
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   "text": "lead (or = 4.7, 95% ci = 1.3-18.2) and petroleum",
   "score": 10.486747741699219,
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  {
   "text": "the presence of the pon1 rs662 (q192r) variant genotype (rr)",
   "score": 10.482171058654785,
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   "text": "rhabdomyosarcoma survivors",
   "score": 10.471575736999512,
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   "score": 10.458608627319336,
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   "score": 10.449224472045898,
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   "score": 10.444025039672852,
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   "text": "with higher maternal exposure to carbon tetrachloride",
   "score": 10.435598373413086,
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  {
   "text": "patients with 11q loss",
   "score": 10.433393478393555,
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   "text": "the presence of three risk genotypes",
   "score": 10.428349494934082,
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   "score": 10.42526912689209,
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   "score": 10.415191650390625,
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   "score": 10.399328231811523,
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   "score": 10.397704124450684,
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   "score": 10.393125534057617,
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   "text": "work related exposure in the preconception period to solvents",
   "score": 10.392315864562988,
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   "score": 10.387432098388672,
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  {
   "text": "and low (below or equal to 7) 1-min apgar score",
   "score": 10.363481521606445,
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   "text": "early life exposure to os",
   "score": 10.3590669631958,
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   "text": "age greater than or equal to 12 years at diagnosis of hodgkin's disease",
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  {
   "text": "the snp rs11669203 located at the mycn binding site of tgfbr3l",
   "score": 10.34730339050293,
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   "text": "subjects carrying three risk genotypes",
   "score": 10.345808029174805,
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  {
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   "score": 10.325316429138184,
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  {
   "text": "rsrc1 rs6441201a allele",
   "score": 10.29412841796875,
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  {
   "text": "pediatric hct survivors",
   "score": 10.256908416748047,
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  {
   "text": "rs1024611) and a new locus (grch38.p12chr17:.34252593 g\u003ec)",
   "score": 10.254653930664062,
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  {
   "text": "childhood infectious diseases (chickenpox",
   "score": 10.242681503295898,
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  {
   "text": "participants harboring the rsrc1 rs6441201a allele",
   "score": 10.238680839538574,
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  {
   "text": "the rs11669203 g\u003ec polymorphism, located in tgfbr3l promoter",
   "score": 10.23642635345459,
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  {
   "text": "alterations in 11q",
   "score": 10.230622291564941,
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  {
   "text": "with diuretics and other antihypertensives",
   "score": 10.216551780700684,
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  {
   "text": "had high mitosis karrhyohexis index (mki) and low ferritin",
   "score": 10.215527534484863,
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   "text": "acute myeloid leukemia",
   "score": 10.208109855651855,
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   "text": "suffered work related exposure in the preconception period to solvents",
   "score": 10.197726249694824,
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   "text": "indigenous children",
   "score": 10.187049865722656,
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   "text": "rapid somatic growth from birth through diagnosis",
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  {
   "text": "paternal exposure to creosote (or = 2.1, 95% ci = 1.1-4.3), dioxin",
   "score": 10.147872924804688,
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  {
   "text": "costello or leopard syndrome",
   "score": 10.143889427185059,
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  {
   "text": "blacks with high-risk disease",
   "score": 10.134727478027344,
   "articlesIDs": [
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  {
   "text": "rs1024611) and a new locus (grch38.p12chr17:.34252593 g\u003ec) on ccl2",
   "score": 10.132781982421875,
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  {
   "text": "retail (or = 2.0, 95% ci = 1.1-3.7) industries",
   "score": 10.1297607421875,
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  {
   "text": "july births",
   "score": 10.125723838806152,
   "articlesIDs": [
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  {
   "text": "patients with neuroblastoma diagnosed before 1 year of age",
   "score": 10.121280670166016,
   "articlesIDs": [
    "9931526"
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  {
   "text": "each 0.5 kg increase in birthweight",
   "score": 10.103805541992188,
   "articlesIDs": [
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  {
   "text": "texas anglo children",
   "score": 10.095983505249023,
   "articlesIDs": [
    "8763250"
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  {
   "text": "imprinting control region 2 loss of methylation (icr2-lom)",
   "score": 10.086888313293457,
   "articlesIDs": [
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  {
   "text": "young parental age, (iii) lower socioeconomic circumstances",
   "score": 10.066202163696289,
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  {
   "text": "ns. young children with costello syndrome",
   "score": 10.063742637634277,
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  {
   "text": "of maternal smoking and drinking habit during pregnancies",
   "score": 10.06317138671875,
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  {
   "text": "number of symptoms (e beta = 2.44) and for stage 4s by platelet count",
   "score": 10.062877655029297,
   "articlesIDs": [
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  {
   "text": "1-repeat, 2-repeat and the newly identified 4-repeat allele)",
   "score": 10.039909362792969,
   "articlesIDs": [
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  {
   "text": "mycn (e beta = 2.78) and number of symptoms",
   "score": 10.03045654296875,
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  {
   "text": ", multiple gestation",
   "score": 10.016349792480469,
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  {
   "text": "a combination of radiotherapy and chemotherapy with alkylating agents",
   "score": 10.001466751098633,
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  {
   "text": "g allele",
   "score": 9.997373580932617,
   "articlesIDs": [
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  {
   "text": "single-copy deletion of the mica and hcp5 genes",
   "score": 9.985422134399414,
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  {
   "text": "gestational age for all",
   "score": 9.965303421020508,
   "articlesIDs": [
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  {
   "text": "noonan (ns), cardio-facial-cutaneous, costello or leopard syndrome",
   "score": 9.948932647705078,
   "articlesIDs": [
    "20029231"
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  {
   "text": "being born either small",
   "score": 9.938474655151367,
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  {
   "text": "hispanics",
   "score": 9.9351806640625,
   "articlesIDs": [
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  {
   "text": "indeno(1,2,3-cd)pyrene and dibenz(a,h)anthracene. hexavalent chromium",
   "score": 9.914421081542969,
   "articlesIDs": [
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  {
   "text": "galnt14",
   "score": 9.908571243286133,
   "articlesIDs": [
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  {
   "text": "the lin28b rs221634 a\u003et polymorphism",
   "score": 9.906767845153809,
   "articlesIDs": [
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  {
   "text": "therapeutic radiation for a childhood malignancy",
   "score": 9.895326614379883,
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  {
   "text": "thyroidal uptake of (131)i",
   "score": 9.890083312988281,
   "articlesIDs": [
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  {
   "text": "maternal education for hodgkin lymphoma",
   "score": 9.888050079345703,
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  {
   "text": "survivors of nbl, wt, and especially aml",
   "score": 9.884750366210938,
   "articlesIDs": [
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  {
   "text": "11q status",
   "score": 9.883825302124023,
   "articlesIDs": [
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  {
   "text": "in utero exposure to metronidazole",
   "score": 9.878039360046387,
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  {
   "text": "with psen1",
   "score": 9.8724365234375,
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  {
   "text": "long exposure to environmental iodine deficiency",
   "score": 9.853410720825195,
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  {
   "text": "therapy of childhood abdominal tumours",
   "score": 9.83053207397461,
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  {
   "text": "to aromatic hydrocarbons",
   "score": 9.829985618591309,
   "articlesIDs": [
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  {
   "text": "fraternal testicular tumors",
   "score": 9.806422233581543,
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  {
   "text": "hormone use related to infertility",
   "score": 9.797383308410645,
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  {
   "text": "i171v germline mutation",
   "score": 9.796955108642578,
   "articlesIDs": [
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  {
   "text": "the germline single nucleotide polymorphism (snp) risk alleles",
   "score": 9.778993606567383,
   "articlesIDs": [
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  {
   "text": "boys",
   "score": 9.777503967285156,
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  {
   "text": "survivors of nbl, wt, and especially aml have impaired hrpf. higher bmi",
   "score": 9.767685890197754,
   "articlesIDs": [
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  {
   "text": "genetically raised bilirubin levels",
   "score": 9.765981674194336,
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  {
   "text": "children with noonan (ns), cardio-facial-cutaneous, costello",
   "score": 9.763797760009766,
   "articlesIDs": [
    "20029231"
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  },
  {
   "text": "preeclampsia",
   "score": 9.746318817138672,
   "articlesIDs": [
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  {
   "text": "the slc19a1 a80a genotype",
   "score": 9.74117374420166,
   "articlesIDs": [
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  {
   "text": "dead box 1 (ddx1)",
   "score": 9.73695182800293,
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  {
   "text": "a child who suffered from both neuroblastoma",
   "score": 9.68874454498291,
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  {
   "text": "being born either small (or 1.4 95% ci 1.0-2.0) or large",
   "score": 9.684988975524902,
   "articlesIDs": [
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  {
   "text": "children born in rural areas",
   "score": 9.682666778564453,
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  {
   "text": "the l28p mutation",
   "score": 9.666057586669922,
   "articlesIDs": [
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  {
   "text": "birthweight, a known hepatoblastoma risk factor. art use",
   "score": 9.662110328674316,
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  {
   "text": "peripheral neuropathy",
   "score": 9.65907096862793,
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  {
   "text": "increased levels of sh2b1",
   "score": 9.635831832885742,
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  {
   "text": "low ferritin.\n\nconclusion:\nthe prognostic strength of mycn-a",
   "score": 9.626450538635254,
   "articlesIDs": [
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  {
   "text": "status of 11q",
   "score": 9.58476734161377,
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  {
   "text": "childhood infectious diseases (chickenpox, mumps",
   "score": 9.572601318359375,
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  {
   "text": "different 120 bp duplication alleles (1-repeat, 2-repeat",
   "score": 9.568120002746582,
   "articlesIDs": [
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  {
   "text": "infants with stage 4s, a significant peak of july births",
   "score": 9.555000305175781,
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  {
   "text": "among children exposed around birth to higher levels of measles",
   "score": 9.549036026000977,
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  {
   "text": "south asian ethnic origin",
   "score": 9.532146453857422,
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  {
   "text": "those with chronic health conditions",
   "score": 9.522977828979492,
   "articlesIDs": [
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  {
   "text": "thyroid carcinoma and acute myeloid leukemia",
   "score": 9.51090145111084,
   "articlesIDs": [
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  {
   "text": "nras gene rs2273267 a\u003et",
   "score": 9.482658386230469,
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