risks-factors / H00046.json
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risk factors
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{
"id": "H00046",
"disease": {
"id": "H00046",
"names": [
"Cholangiocarcinoma",
"SUPERGRP Solid tumor [DS:H02421]"
],
"dbLinks": {
"icd10": [
"C22"
],
"mesh": [
"D018281"
]
},
"category": "Cancer"
},
"riskFactors": [
{
"text": "diabetes mellitus (dm)",
"score": 14.432968139648438,
"articlesIDs": [
"25987063",
"28036262",
"24923595",
"25910864",
"34036430",
"25593465",
"27386429"
]
},
{
"text": "diabetes mellitus (dm), cholecystolithiasis",
"score": 14.262475967407227,
"articlesIDs": [
"25593465"
]
},
{
"text": "patients with psc-ibd",
"score": 14.2235746383667,
"articlesIDs": [
"28376583",
"32445859"
]
},
{
"text": "hepatitis b virus (hbv) infection, diabetes mellitus (dm)",
"score": 14.221749305725098,
"articlesIDs": [
"25593465"
]
},
{
"text": "diabetes mellitus (dm), cholecystolithiasis, choledocholithiasis",
"score": 14.197494506835938,
"articlesIDs": [
"25593465"
]
},
{
"text": "hbv, older age, male sex, diabetes, smoking, alcohol drinking, and obesity",
"score": 14.193053245544434,
"articlesIDs": [
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]
},
{
"text": "diabetes mellitus, family history of cancer",
"score": 14.134675025939941,
"articlesIDs": [
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]
},
{
"text": "cholelithiasis, hbv",
"score": 14.133916854858398,
"articlesIDs": [
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]
},
{
"text": "diabetes mellitus, family history of cancer, and gallbladder stones",
"score": 14.128055572509766,
"articlesIDs": [
"37540502"
]
},
{
"text": "cholecystolithiasis, choledocholithiasis, and hepatolithiasis",
"score": 14.07333755493164,
"articlesIDs": [
"25593465"
]
},
{
"text": "choledocholithiasis, cholelithiasis, hbv",
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"articlesIDs": [
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]
},
{
"text": "cholelithiasis, hbv, older age, male sex, diabetes, smoking, alcohol drinking",
"score": 14.051994323730469,
"articlesIDs": [
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]
},
{
"text": "choledocholithiasis and hepatolithiasis",
"score": 14.051168441772461,
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]
},
{
"text": "hbv infection",
"score": 14.027481079101562,
"articlesIDs": [
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},
{
"text": "heavy smoking, choledocholithiasis and hepatolithiasis",
"score": 13.986027717590332,
"articlesIDs": [
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]
},
{
"text": "heavy alcohol consumption",
"score": 13.969074249267578,
"articlesIDs": [
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},
{
"text": "choledocholithiasis, dm",
"score": 13.945783615112305,
"articlesIDs": [
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},
{
"text": "diabetes and chronic liver diseases",
"score": 13.935006141662598,
"articlesIDs": [
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]
},
{
"text": "patients with type 2 diabetes mellitus (t2dm)",
"score": 13.921634674072266,
"articlesIDs": [
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},
{
"text": "hepatolithiasis, choledocholithiasis, dm",
"score": 13.916335105895996,
"articlesIDs": [
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]
},
{
"text": "family history of cancer, liquor consumption",
"score": 13.912690162658691,
"articlesIDs": [
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},
{
"text": "eating raw cyprinoid fish",
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},
{
"text": "being asian, diabetes mellitus",
"score": 13.890081405639648,
"articlesIDs": [
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},
{
"text": "hbv and hcv infection",
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{
"text": "early adulthood onset of obesity",
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},
{
"text": "choledocholithiasis, dm, and heavy smoking",
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},
{
"text": "biliary stone disease",
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{
"text": "hepatitis b virus (hbv) infection, heavy alcohol consumption",
"score": 13.846931457519531,
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},
{
"text": "eating raw cyprinoid fish, family history of cancer, liquor consumption",
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{
"text": "non-alcoholic fatty liver disease (nafld)",
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},
{
"text": "opisthorchis viverrini infection, eating raw cyprinoid fish",
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},
{
"text": "liver cirrhosis, and biliary stone disease",
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},
{
"text": "being asian, diabetes mellitus, family history of cancer",
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{
"text": "hbv infection and heavy alcohol consumption",
"score": 13.802742004394531,
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},
{
"text": "liver atrophy and precancerous lesions with malignant transformation",
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},
{
"text": "liver fat content (lfc)",
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{
"text": "family history of cancer, liquor consumption, and taking praziquantel",
"score": 13.793834686279297,
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{
"text": "chemical carcinogen exposure",
"score": 13.784465789794922,
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},
{
"text": "fibropolycystic liver disease, and chemical carcinogen exposure",
"score": 13.779560089111328,
"articlesIDs": [
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},
{
"text": "hysterectomy and long-term oral contraceptive use",
"score": 13.76773452758789,
"articlesIDs": [
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},
{
"text": "bile duct conditions",
"score": 13.745973587036133,
"articlesIDs": [
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]
},
{
"text": "peritransplant lymphopenia",
"score": 13.737574577331543,
"articlesIDs": [
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},
{
"text": "non-alcoholic steatohepatitis (nash)",
"score": 13.731302261352539,
"articlesIDs": [
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},
{
"text": "1-sd increase in the liver fat content (lfc)",
"score": 13.730624198913574,
"articlesIDs": [
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},
{
"text": "hcv infection and age ≥49 years",
"score": 13.726034164428711,
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},
{
"text": "viral hepatitis, alcohol-related disorders, and bile duct conditions",
"score": 13.718488693237305,
"articlesIDs": [
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},
{
"text": "non-alcoholic fatty liver disease (nafld), and cholelithiasis",
"score": 13.718148231506348,
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},
{
"text": "patients with a diagnosis of diabetes mellitus",
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"articlesIDs": [
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},
{
"text": "hbv or hcv infections",
"score": 13.702457427978516,
"articlesIDs": [
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},
{
"text": "cholangioenterostomy",
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"articlesIDs": [
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},
{
"text": "hbv and hcv infections",
"score": 13.692935943603516,
"articlesIDs": [
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},
{
"text": "donor age",
"score": 13.665239334106445,
"articlesIDs": [
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},
{
"text": "heavy alcohol consumption, a family history of liver cancer",
"score": 13.663318634033203,
"articlesIDs": [
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},
{
"text": "liver fluke infection",
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},
{
"text": "igg4-sc patients",
"score": 13.651054382324219,
"articlesIDs": [
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},
{
"text": "meld, and donor age",
"score": 13.648452758789062,
"articlesIDs": [
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},
{
"text": "liver fat content (lfc), non-alcoholic fatty liver disease (nafld)",
"score": 13.643231391906738,
"articlesIDs": [
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},
{
"text": "inflammatory bowel diseases (ibd)",
"score": 13.638635635375977,
"articlesIDs": [
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},
{
"text": "cholangiocarcinoma, meld",
"score": 13.628582954406738,
"articlesIDs": [
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]
},
{
"text": "liver atrophy, precancerous lesions",
"score": 13.628448486328125,
"articlesIDs": [
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},
{
"text": "cholangiocarcinoma, meld, and donor age",
"score": 13.620268821716309,
"articlesIDs": [
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]
},
{
"text": "primary sclerosing cholangitis (psc)",
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},
{
"text": "p-c type, and biliary lipase level ≥45,000 iu/l",
"score": 13.605875968933105,
"articlesIDs": [
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]
},
{
"text": "excess body weight",
"score": 13.605704307556152,
"articlesIDs": [
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},
{
"text": "bile duct stones including choledocholithiasis",
"score": 13.605062484741211,
"articlesIDs": [
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},
{
"text": "active inpatient status",
"score": 13.592456817626953,
"articlesIDs": [
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{
"text": "underexpression of mir-126-3p",
"score": 13.576519012451172,
"articlesIDs": [
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]
},
{
"text": "hemochromatosis",
"score": 13.57554817199707,
"articlesIDs": [
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]
},
{
"text": "biliary complications, cholangiocarcinoma, meld",
"score": 13.563949584960938,
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]
},
{
"text": "biliary complications, cholangiocarcinoma, meld, and donor age",
"score": 13.555635452270508,
"articlesIDs": [
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]
},
{
"text": "obesity (pooled or 1.52, 95 % ci 1.13-1.89), and excess body weight",
"score": 13.553695678710938,
"articlesIDs": [
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},
{
"text": "male gender",
"score": 13.548182487487793,
"articlesIDs": [
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},
{
"text": "parasitic infection (opisthorchis viverrini or clonorchis sinensis)",
"score": 13.534927368164062,
"articlesIDs": [
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},
{
"text": "recipients over the age of 50 with non-alcoholic steatohepatitis (nash)",
"score": 13.534378051757812,
"articlesIDs": [
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},
{
"text": "precancerous lesions, postoperative repeated cholangitis",
"score": 13.529491424560547,
"articlesIDs": [
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{
"text": "liver atrophy, precancerous lesions, postoperative repeated cholangitis",
"score": 13.527913093566895,
"articlesIDs": [
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]
},
{
"text": "patients with inflammatory bowel diseases (ibds)",
"score": 13.50379753112793,
"articlesIDs": [
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},
{
"text": "age ≥45 years, p-c type, and biliary lipase level ≥45,000 iu/l",
"score": 13.487590789794922,
"articlesIDs": [
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},
{
"text": "females \u003e50 years with alcohol-associated liver disease and hcc/cca",
"score": 13.486249923706055,
"articlesIDs": [
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},
{
"text": "type 2 diabetes mellitus (t2dm) and nonalcoholic fatty liver disease (nafld)",
"score": 13.483686447143555,
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},
{
"text": "patients with ibd",
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"articlesIDs": [
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"text": "patients with inflammatory bowel disease (ibd)",
"score": 13.452692031860352,
"articlesIDs": [
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},
{
"text": "high serum ferritin",
"score": 13.452646255493164,
"articlesIDs": [
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},
{
"text": "repeated use of pzq treatment",
"score": 13.45233154296875,
"articlesIDs": [
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},
{
"text": "thyrotoxicosis and hemochromatosis",
"score": 13.452019691467285,
"articlesIDs": [
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},
{
"text": "cholangioenterostomy, diabetes, early and complete stone removal",
"score": 13.432168960571289,
"articlesIDs": [
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},
{
"text": "chronic infection with epstein-barr virus, hepatitis b and c viruses",
"score": 13.429964065551758,
"articlesIDs": [
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},
{
"text": "high serum ggt concentration",
"score": 13.429913520812988,
"articlesIDs": [
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},
{
"text": "hepatolithiasis, primary sclerosing cholangitis",
"score": 13.429872512817383,
"articlesIDs": [
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},
{
"text": "human immunodeficiency virus (hiv) type 1, human papillomavirus (hpv)",
"score": 13.396751403808594,
"articlesIDs": [
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},
{
"text": "long-term oral contraceptive use (9+ years)",
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"articlesIDs": [
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{
"text": "chronic viral hepatitis b/c infection",
"score": 13.387968063354492,
"articlesIDs": [
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{
"text": "both-sided liver atrophy",
"score": 13.353841781616211,
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{
"text": "psc-ibd patients",
"score": 13.343103408813477,
"articlesIDs": [
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{
"text": "recipients with primary sclerosing cholangitis (psc)",
"score": 13.331069946289062,
"articlesIDs": [
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},
{
"text": "biliary stent placement, a diagnosis of cholangiocarcinoma",
"score": 13.325984954833984,
"articlesIDs": [
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},
{
"text": "male gender, suspicious bc",
"score": 13.321666717529297,
"articlesIDs": [
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},
{
"text": "patients with intrahepatic cholangiocarcinoma",
"score": 13.311635971069336,
"articlesIDs": [
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},
{
"text": "frequency of raw fresh fish consumption",
"score": 13.310977935791016,
"articlesIDs": [
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{
"text": "non-alcoholic fatty liver disease(nafld)",
"score": 13.299766540527344,
"articlesIDs": [
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},
{
"text": "hepatitis b and c viruses, kaposi sarcoma herpes virus",
"score": 13.291059494018555,
"articlesIDs": [
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},
{
"text": "hepatitis b and hepatitis c",
"score": 13.279894828796387,
"articlesIDs": [
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},
{
"text": "pibd patients treated with thiopurines",
"score": 13.278483390808105,
"articlesIDs": [
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},
{
"text": "ca199 \u003e 100 iu/ml",
"score": 13.27829360961914,
"articlesIDs": [
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{
"text": "patients with ibd and primary sclerosing cholangitis",
"score": 13.275472640991211,
"articlesIDs": [
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},
{
"text": "cirrhosis, and hepatitis b and c viruses",
"score": 13.267701148986816,
"articlesIDs": [
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},
{
"text": "cirrhosis, hepatitis b and hepatitis c",
"score": 13.259654998779297,
"articlesIDs": [
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},
{
"text": "being overweight (pooled or 1.30, 95 % ci 1.13-1.49), obesity",
"score": 13.253668785095215,
"articlesIDs": [
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},
{
"text": "o felineus-infected individuals",
"score": 13.25322151184082,
"articlesIDs": [
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},
{
"text": "elevation of alp, bilirubin, alt, ast, ggt, cea and ca19-9",
"score": 13.245084762573242,
"articlesIDs": [
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},
{
"text": "metabolic syndrome",
"score": 13.222957611083984,
"articlesIDs": [
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},
{
"text": "diagnosis of cholangiocarcinoma, and active inpatient status",
"score": 13.21896743774414,
"articlesIDs": [
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},
{
"text": "ifg",
"score": 13.218263626098633,
"articlesIDs": [
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},
{
"text": "history of o. viverrini infection",
"score": 13.211288452148438,
"articlesIDs": [
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{
"text": "primary sclerosing cholangitis (psc) and inflammatory bowel disease (ibd)",
"score": 13.202848434448242,
"articlesIDs": [
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},
{
"text": "long-term use of ppis",
"score": 13.198622703552246,
"articlesIDs": [
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{
"text": "both-sided intrahepatic duct stones",
"score": 13.189809799194336,
"articlesIDs": [
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{
"text": "increased iron levels",
"score": 13.185757637023926,
"articlesIDs": [
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},
{
"text": "prolonged duration of ibd",
"score": 13.184725761413574,
"articlesIDs": [
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},
{
"text": "gallstone and liver fat accumulation",
"score": 13.176597595214844,
"articlesIDs": [
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},
{
"text": "pancreaticobiliary maljunction (pbm)",
"score": 13.170727729797363,
"articlesIDs": [
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},
{
"text": "clonorchis sinensis, opisthorchis viverrini, and schistosoma haematobium",
"score": 13.169431686401367,
"articlesIDs": [
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]
},
{
"text": "insomnia and nap during the day",
"score": 13.166727066040039,
"articlesIDs": [
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{
"text": "both-sided intrahepatic duct stones, and liver atrophy at any location",
"score": 13.151920318603516,
"articlesIDs": [
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},
{
"text": "persons with the wild-type and c1/c2 + c2/c2 genotype",
"score": 13.138677597045898,
"articlesIDs": [
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]
},
{
"text": "cysts and stones in the bile ducts, cirrhosis, and hepatitis b and c viruses",
"score": 13.131946563720703,
"articlesIDs": [
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]
},
{
"text": "advanced erc findings, male gender",
"score": 13.115789413452148,
"articlesIDs": [
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]
},
{
"text": "helicobacter pylori, clonorchis sinensis",
"score": 13.111549377441406,
"articlesIDs": [
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},
{
"text": "obesity and diabetes",
"score": 13.099947929382324,
"articlesIDs": [
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},
{
"text": "hepatitis b virus infection",
"score": 13.095739364624023,
"articlesIDs": [
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},
{
"text": "current smoking",
"score": 13.091842651367188,
"articlesIDs": [
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},
{
"text": "patients who receive a diagnosis of psc at an age younger than 40 years",
"score": 13.074050903320312,
"articlesIDs": [
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},
{
"text": "close contact with cats and dogs",
"score": 13.073914527893066,
"articlesIDs": [
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},
{
"text": "repeated pzq treatments",
"score": 13.059402465820312,
"articlesIDs": [
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},
{
"text": "use of dpp-4 inhibitors, and possibly glp-1 receptor agonists",
"score": 13.04928207397461,
"articlesIDs": [
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]
},
{
"text": "dyslipidemia, and metabolic syndrome",
"score": 13.047351837158203,
"articlesIDs": [
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},
{
"text": "current smoking (or=1.90, 95% ci=1.08-3.34), heavy alcohol drinking",
"score": 13.04710865020752,
"articlesIDs": [
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},
{
"text": "patients with ulcerative colitis",
"score": 13.044979095458984,
"articlesIDs": [
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},
{
"text": "paediatric-onset inflammatory bowel disease (pibd)",
"score": 13.040369033813477,
"articlesIDs": [
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