{
 "id": "H00037",
 "disease": {
  "id": "H00037",
  "names": [
   "Rhabdomyosarcoma"
  ],
  "dbLinks": {
   "icd10": [
    "C49"
   ],
   "mesh": [
    "D018232"
   ]
  },
  "category": "Cancer",
  "description": "Rhabdomyosarcomas (RMSs) are soft tissue sarcomas that are one of the most common neoplasms in children and adolescents. RMSs are presumed to be associated with the skeletal muscle lineage, although those tumors can be present in organs histologically lacking skeletal muscle, like prostate, urinary bladder or gallbladder. RMS is divided into two major subtypes: embryonal (ERMS) and alveolar (ARMS). Alveolar rhabdomyosarcoma (ARMS) is a pediatric sarcoma that typically occurs in older children predominantly arising in the trunk and extremities, and exhibits a worse prognosis than other types of RMSs. ARMS is associated with 2;13 or 1;13 chromosomal translocations, which generate PAX3-FOXO1A and PAX7-FOXO1A fusion products, respectively. These translocations result in altered expression, function, and subcellular localization of the fusion products relative to the wild-type proteins, and ultimately contribute to oncogenic behavior by modifying growth, differentiation, and apoptosis pathways."
 },
 "riskFactors": [
  {
   "text": "neuroblastoma, rhabdomyosarcoma, or bone/cartilage cancer",
   "score": 13.703069686889648,
   "articlesIDs": [
    "33533203"
   ]
  },
  {
   "text": "use of prenatal hematinics/iron supplements",
   "score": 13.660268783569336,
   "articlesIDs": [
    "32851243"
   ]
  },
  {
   "text": "bk virus in the urine",
   "score": 13.627668380737305,
   "articlesIDs": [
    "23954584"
   ]
  },
  {
   "text": "germline mutations in ras signalling pathway genes",
   "score": 13.625127792358398,
   "articlesIDs": [
    "25742478"
   ]
  },
  {
   "text": "use of prenatal hematinics/iron supplements, and higher parity",
   "score": 13.588574409484863,
   "articlesIDs": [
    "32851243"
   ]
  },
  {
   "text": "patients with acute lymphoid leukemia (in relapse), neuroblastoma",
   "score": 13.546358108520508,
   "articlesIDs": [
    "33533203"
   ]
  },
  {
   "text": "administration of chemotherapy",
   "score": 13.484949111938477,
   "articlesIDs": [
    "33533203"
   ]
  },
  {
   "text": "embryonal rhabdomyosarcoma",
   "score": 13.43436050415039,
   "articlesIDs": [
    "1642235",
    "2313328"
   ]
  },
  {
   "text": "children with rhabdomyosarcoma",
   "score": 13.413915634155273,
   "articlesIDs": [
    "15852362",
    "26193998"
   ]
  },
  {
   "text": "previous bone marrow or peripheral blood stem cell transplantation",
   "score": 13.365013122558594,
   "articlesIDs": [
    "23954584"
   ]
  },
  {
   "text": "mothers' marijuana use during the year before their child's birth",
   "score": 13.337638854980469,
   "articlesIDs": [
    "8318638"
   ]
  },
  {
   "text": "young mothers of patients with rhabdomyosarcoma",
   "score": 13.327287673950195,
   "articlesIDs": [
    "8839555"
   ]
  },
  {
   "text": "older age, previous bone marrow or peripheral blood stem cell transplantation",
   "score": 13.295733451843262,
   "articlesIDs": [
    "23954584"
   ]
  },
  {
   "text": "cyclophosphamide or busulfan chemotherapy",
   "score": 13.263357162475586,
   "articlesIDs": [
    "23954584"
   ]
  },
  {
   "text": "male gender, cyclophosphamide or busulfan chemotherapy",
   "score": 13.238014221191406,
   "articlesIDs": [
    "23954584"
   ]
  },
  {
   "text": "lymphovascular invasion (lvi)",
   "score": 13.131242752075195,
   "articlesIDs": [
    "31824805"
   ]
  },
  {
   "text": "embryonal rhabdomyosarcoma (rr, 3.74), and male sex",
   "score": 13.096696853637695,
   "articlesIDs": [
    "2313328"
   ]
  },
  {
   "text": "autologous stem cell transplantation (sct)",
   "score": 13.064083099365234,
   "articlesIDs": [
    "30053029"
   ]
  },
  {
   "text": "children with pleomorphic and embryonal rhabdomyosarcoma",
   "score": 13.046062469482422,
   "articlesIDs": [
    "26193998"
   ]
  },
  {
   "text": "allogeneic bone marrow or peripheral blood stem cell transplantation",
   "score": 12.980209350585938,
   "articlesIDs": [
    "23954584"
   ]
  },
  {
   "text": "high-grade and care histology",
   "score": 12.94742488861084,
   "articlesIDs": [
    "31824805"
   ]
  },
  {
   "text": "people who had childhood rhabdomyosarcoma",
   "score": 12.934535026550293,
   "articlesIDs": [
    "31743457"
   ]
  },
  {
   "text": "children born premature",
   "score": 12.925881385803223,
   "articlesIDs": [
    "30608983"
   ]
  },
  {
   "text": "fathers' marijuana use",
   "score": 12.92507266998291,
   "articlesIDs": [
    "8318638"
   ]
  },
  {
   "text": "age at diagnosis less than 24 months",
   "score": 12.909601211547852,
   "articlesIDs": [
    "2313328"
   ]
  },
  {
   "text": "children who had undergone both chemotherapy and radiotherapy",
   "score": 12.90310287475586,
   "articlesIDs": [
    "31743457"
   ]
  },
  {
   "text": "each 500 g increase in birth weight",
   "score": 12.826946258544922,
   "articlesIDs": [
    "19997102"
   ]
  },
  {
   "text": "individuals treated for childhood all",
   "score": 12.81798267364502,
   "articlesIDs": [
    "1785295"
   ]
  },
  {
   "text": "hispanics",
   "score": 12.806520462036133,
   "articlesIDs": [
    "36230854",
    "32672899"
   ]
  },
  {
   "text": "survivors with childhood non-cns embryonal tumours",
   "score": 12.771675109863281,
   "articlesIDs": [
    "28822326"
   ]
  },
  {
   "text": "the number of cancer medications taken by the patient",
   "score": 12.748064041137695,
   "articlesIDs": [
    "33533203"
   ]
  },
  {
   "text": "a family history of malignancy, use of prenatal hematinics/iron supplements",
   "score": 12.738748550415039,
   "articlesIDs": [
    "32851243"
   ]
  },
  {
   "text": "children who have a first-degree relative with cancer",
   "score": 12.683873176574707,
   "articlesIDs": [
    "25809884"
   ]
  },
  {
   "text": "brain tumor",
   "score": 12.671764373779297,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "birth control use (or 1.45, 95% ci 0.96-2.18), anemia during pregnancy",
   "score": 12.667126655578613,
   "articlesIDs": [
    "24831857"
   ]
  },
  {
   "text": "brain tumor and npc",
   "score": 12.656586647033691,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "survivors of childhood cancer",
   "score": 12.628799438476562,
   "articlesIDs": [
    "31743457"
   ]
  },
  {
   "text": "high birth weight",
   "score": 12.62397575378418,
   "articlesIDs": [
    "19997102",
    "24831857"
   ]
  },
  {
   "text": "being born preterm",
   "score": 12.612602233886719,
   "articlesIDs": [
    "30980537"
   ]
  },
  {
   "text": "maternal cocaine use",
   "score": 12.611757278442383,
   "articlesIDs": [
    "8318638"
   ]
  },
  {
   "text": "late age at birth of index child",
   "score": 12.57573127746582,
   "articlesIDs": [
    "2313328"
   ]
  },
  {
   "text": "x-ray exposure during the first trimester",
   "score": 12.573338508605957,
   "articlesIDs": [
    "19293315"
   ]
  },
  {
   "text": "abnormal vaginal bleeding during pregnancy",
   "score": 12.558975219726562,
   "articlesIDs": [
    "24831857"
   ]
  },
  {
   "text": "young children with costello syndrome",
   "score": 12.557060241699219,
   "articlesIDs": [
    "20029231"
   ]
  },
  {
   "text": "chemotherapy with an alkylating agent and radiotherapy",
   "score": 12.5355224609375,
   "articlesIDs": [
    "8426203"
   ]
  },
  {
   "text": "family history and multifocality",
   "score": 12.526937484741211,
   "articlesIDs": [
    "12424773"
   ]
  },
  {
   "text": "lymphogenous histotype",
   "score": 12.499258041381836,
   "articlesIDs": [
    "25501082"
   ]
  },
  {
   "text": "having a first-degree relative with a cancer history",
   "score": 12.446086883544922,
   "articlesIDs": [
    "25809884"
   ]
  },
  {
   "text": "having a congenital malformation",
   "score": 12.4420166015625,
   "articlesIDs": [
    "30980537"
   ]
  },
  {
   "text": "accelerated in utero growth",
   "score": 12.435270309448242,
   "articlesIDs": [
    "19997102"
   ]
  },
  {
   "text": "premenopausal breast cancer in the mother, late age at birth of index child",
   "score": 12.383929252624512,
   "articlesIDs": [
    "2313328"
   ]
  },
  {
   "text": "preterm birth",
   "score": 12.381708145141602,
   "articlesIDs": [
    "30608983",
    "24831857"
   ]
  },
  {
   "text": "anemia during pregnancy (or 1.27, 95% ci 0.81-1.99), and preterm birth",
   "score": 12.368106842041016,
   "articlesIDs": [
    "24831857"
   ]
  },
  {
   "text": "asian pacific islanders",
   "score": 12.344059944152832,
   "articlesIDs": [
    "36230854"
   ]
  },
  {
   "text": "any x-ray examination of the mother during pregnancy",
   "score": 12.339004516601562,
   "articlesIDs": [
    "19293315"
   ]
  },
  {
   "text": "history of hodgkin lymphoma (hl)",
   "score": 12.3303804397583,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "clear cell/angiosarcoma/rhabdomyosarcoma/epithelioid (care) histology",
   "score": 12.32423210144043,
   "articlesIDs": [
    "31824805"
   ]
  },
  {
   "text": "first-degree relatives of patients with sts",
   "score": 12.290700912475586,
   "articlesIDs": [
    "8839555"
   ]
  },
  {
   "text": "history of hodgkin lymphoma (hl), brain tumor",
   "score": 12.281418800354004,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "low birth weight",
   "score": 12.27719497680664,
   "articlesIDs": [
    "24831857"
   ]
  },
  {
   "text": "those with congenital malformations and other adverse birth outcomes",
   "score": 12.270873069763184,
   "articlesIDs": [
    "30980537"
   ]
  },
  {
   "text": "history of hodgkin lymphoma (hl), brain tumor and npc",
   "score": 12.266241073608398,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "low ses",
   "score": 12.261157035827637,
   "articlesIDs": [
    "36230854"
   ]
  },
  {
   "text": "non-hispanic blacks (4.04 [2.32−7.04]), asian pacific islanders",
   "score": 12.244571685791016,
   "articlesIDs": [
    "36230854"
   ]
  },
  {
   "text": "late age at first birth",
   "score": 12.24280071258545,
   "articlesIDs": [
    "2313328"
   ]
  },
  {
   "text": "cancer type",
   "score": 12.230464935302734,
   "articlesIDs": [
    "16258096"
   ]
  },
  {
   "text": "maternal age above 30 at child's birth",
   "score": 12.215278625488281,
   "articlesIDs": [
    "2815346"
   ]
  },
  {
   "text": "brain tumor and npc, as well as cervical irradiation",
   "score": 12.152616500854492,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "asian pacific islanders (2.99 [1.75−5.12]), hispanics",
   "score": 12.11160659790039,
   "articlesIDs": [
    "36230854"
   ]
  },
  {
   "text": "low ses ayas",
   "score": 12.098965644836426,
   "articlesIDs": [
    "36230854"
   ]
  },
  {
   "text": "young children with pleomorphic and embryonal histologies",
   "score": 12.089179992675781,
   "articlesIDs": [
    "26193998"
   ]
  },
  {
   "text": "asian/pacific islanders",
   "score": 12.083722114562988,
   "articlesIDs": [
    "32672899"
   ]
  },
  {
   "text": "treatment with platinum derivatives",
   "score": 12.06673526763916,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "late age at first birth (rr, 5.13), late age at birth of index child",
   "score": 11.979447364807129,
   "articlesIDs": [
    "2313328"
   ]
  },
  {
   "text": "associated complications, and cancer type",
   "score": 11.95637035369873,
   "articlesIDs": [
    "16258096"
   ]
  },
  {
   "text": "use of any recreational drug. fathers' marijuana use",
   "score": 11.951395034790039,
   "articlesIDs": [
    "8318638"
   ]
  },
  {
   "text": "large size for gestational age",
   "score": 11.940799713134766,
   "articlesIDs": [
    "19997102"
   ]
  },
  {
   "text": "head/neck irradiation",
   "score": 11.90029525756836,
   "articlesIDs": [
    "25241607"
   ]
  },
  {
   "text": "klippel-trenaunay syndrome (kts)",
   "score": 11.899539947509766,
   "articlesIDs": [
    "31045469"
   ]
  },
  {
   "text": "genetic abnormalities",
   "score": 11.875349044799805,
   "articlesIDs": [
    "8426203"
   ]
  },
  {
   "text": "prenatal use of hematinics/iron supplements",
   "score": 11.834112167358398,
   "articlesIDs": [
    "32851243"
   ]
  },
  {
   "text": "lymphogenous histotype and primary tumors invading the subcutis",
   "score": 11.795807838439941,
   "articlesIDs": [
    "25501082"
   ]
  },
  {
   "text": "lower birth weight in children with ewing's tumour",
   "score": 11.785959243774414,
   "articlesIDs": [
    "3224086"
   ]
  },
  {
   "text": "patients with cpt",
   "score": 11.748733520507812,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "early onset of soft tissue sarcoma in the index child",
   "score": 11.741336822509766,
   "articlesIDs": [
    "2313328"
   ]
  },
  {
   "text": "initial therapy with radiation and chemotherapeutic agents",
   "score": 11.73153305053711,
   "articlesIDs": [
    "15852362"
   ]
  },
  {
   "text": "beckwith-wiedemann syndrome (bws)",
   "score": 11.722845077514648,
   "articlesIDs": [
    "7472929",
    "1583638"
   ]
  },
  {
   "text": "lymphogenous histotype and a primary tumor invading the subcutis",
   "score": 11.70673942565918,
   "articlesIDs": [
    "25501082"
   ]
  },
  {
   "text": "hispanics (2.37 [1.85−3.04]), and low ses",
   "score": 11.701436996459961,
   "articlesIDs": [
    "36230854"
   ]
  },
  {
   "text": "bone invasion (bi)",
   "score": 11.689481735229492,
   "articlesIDs": [
    "31824805"
   ]
  },
  {
   "text": "families of patients with cpt",
   "score": 11.66543960571289,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "in utero\" exposure to diagnostic radiation",
   "score": 11.612119674682617,
   "articlesIDs": [
    "2815346"
   ]
  },
  {
   "text": "patients who had received cranial radiation",
   "score": 11.610045433044434,
   "articlesIDs": [
    "1785295"
   ]
  },
  {
   "text": "low fetal growth",
   "score": 11.604761123657227,
   "articlesIDs": [
    "30980537"
   ]
  },
  {
   "text": "history of retinoblastoma as the primary cancer",
   "score": 11.601420402526855,
   "articlesIDs": [
    "30053029"
   ]
  },
  {
   "text": "mothers of children with solid tumours",
   "score": 11.600685119628906,
   "articlesIDs": [
    "3348946"
   ]
  },
  {
   "text": "adolescent and young adult patients",
   "score": 11.541238784790039,
   "articlesIDs": [
    "33791777"
   ]
  },
  {
   "text": "low-dose etoposide",
   "score": 11.474050521850586,
   "articlesIDs": [
    "8202048"
   ]
  },
  {
   "text": "patients with grade 3 care tumors",
   "score": 11.473417282104492,
   "articlesIDs": [
    "31824805"
   ]
  },
  {
   "text": "children with noonan (ns)",
   "score": 11.451480865478516,
   "articlesIDs": [
    "20029231"
   ]
  },
  {
   "text": "age group, year of discharge",
   "score": 11.423352241516113,
   "articlesIDs": [
    "16258096"
   ]
  },
  {
   "text": "obesity",
   "score": 11.364801406860352,
   "articlesIDs": [
    "33243845"
   ]
  },
  {
   "text": "fibromatous neoplasms",
   "score": 11.344523429870605,
   "articlesIDs": [
    "15852362"
   ]
  },
  {
   "text": "age group, year of discharge, associated complications, and cancer type",
   "score": 11.337188720703125,
   "articlesIDs": [
    "16258096"
   ]
  },
  {
   "text": "cancer type, and associated complications",
   "score": 11.296302795410156,
   "articlesIDs": [
    "16258096"
   ]
  },
  {
   "text": "race, age, cancer type",
   "score": 11.238649368286133,
   "articlesIDs": [
    "16258096"
   ]
  },
  {
   "text": "treatment for childhood cancer",
   "score": 11.203910827636719,
   "articlesIDs": [
    "8494698"
   ]
  },
  {
   "text": "patients who received combined modality therapy",
   "score": 11.191461563110352,
   "articlesIDs": [
    "15852362"
   ]
  },
  {
   "text": "those whose relatives were diagnosed with cancer at \u003c30 years of age",
   "score": 11.1901273727417,
   "articlesIDs": [
    "25809884"
   ]
  },
  {
   "text": "children with beckwith-wiedemann syndrome (bws)",
   "score": 11.157814025878906,
   "articlesIDs": [
    "7472929"
   ]
  },
  {
   "text": "lymphogenous histotype (p \u003c 0.01) and a primary tumor in the subcutis",
   "score": 11.149828910827637,
   "articlesIDs": [
    "25501082"
   ]
  },
  {
   "text": "tp53-positive individuals",
   "score": 11.144061088562012,
   "articlesIDs": [
    "20522432"
   ]
  },
  {
   "text": "\"in utero\" exposure to diagnostic radiation",
   "score": 11.042707443237305,
   "articlesIDs": [
    "2815346"
   ]
  },
  {
   "text": "both maternal age above 30 at child's birth",
   "score": 11.034897804260254,
   "articlesIDs": [
    "2815346"
   ]
  },
  {
   "text": "those with embryonal rms",
   "score": 11.022369384765625,
   "articlesIDs": [
    "25809884"
   ]
  },
  {
   "text": "soft tissue sarcoma (sts)",
   "score": 11.012368202209473,
   "articlesIDs": [
    "15852362"
   ]
  },
  {
   "text": "nh blacks",
   "score": 10.988323211669922,
   "articlesIDs": [
    "32672899"
   ]
  },
  {
   "text": "survivors of aya sarcoma",
   "score": 10.951146125793457,
   "articlesIDs": [
    "24752471"
   ]
  },
  {
   "text": "survivors of aya bone and soft tissue sarcoma",
   "score": 10.935470581054688,
   "articlesIDs": [
    "24752471"
   ]
  },
  {
   "text": "leopard syndrome",
   "score": 10.930902481079102,
   "articlesIDs": [
    "20029231"
   ]
  },
  {
   "text": "more children with rhabdomyosarcoma who received antibiotics soon after birth",
   "score": 10.92462158203125,
   "articlesIDs": [
    "3224086"
   ]
  },
  {
   "text": "first trimester exposure",
   "score": 10.900529861450195,
   "articlesIDs": [
    "19293315"
   ]
  },
  {
   "text": "patients with lymph node metastases",
   "score": 10.863983154296875,
   "articlesIDs": [
    "29529647"
   ]
  },
  {
   "text": "li-fraumeni syndrome (lfs)",
   "score": 10.85525131225586,
   "articlesIDs": [
    "20522432",
    "8426203"
   ]
  },
  {
   "text": "duchenne muscular dystrophy (dmd)",
   "score": 10.833826065063477,
   "articlesIDs": [
    "34805447"
   ]
  },
  {
   "text": "both parents' marijuana use",
   "score": 10.783058166503906,
   "articlesIDs": [
    "8318638"
   ]
  },
  {
   "text": "ulceration or lymphedema associated with vlm or capillary malformations",
   "score": 10.74319076538086,
   "articlesIDs": [
    "31045469"
   ]
  },
  {
   "text": "those receiving cyclophosphamide but no etoposide",
   "score": 10.694272994995117,
   "articlesIDs": [
    "8202048"
   ]
  },
  {
   "text": "patients with primary rhabdomyosarcoma in an extremity",
   "score": 10.685983657836914,
   "articlesIDs": [
    "28590782"
   ]
  },
  {
   "text": "calcium/calmodulin-dependent protein kinase id)",
   "score": 10.665115356445312,
   "articlesIDs": [
    "33243845"
   ]
  },
  {
   "text": "ns. young children with costello syndrome",
   "score": 10.586987495422363,
   "articlesIDs": [
    "20029231"
   ]
  },
  {
   "text": "patients who initially received combined modality therapy",
   "score": 10.560903549194336,
   "articlesIDs": [
    "15852362"
   ]
  },
  {
   "text": "noonan (ns), cardio-facial-cutaneous, costello or leopard syndrome",
   "score": 10.532519340515137,
   "articlesIDs": [
    "20029231"
   ]
  },
  {
   "text": "dental x-rays",
   "score": 10.530187606811523,
   "articlesIDs": [
    "19293315"
   ]
  },
  {
   "text": "higher cumulative cyclophosphamide dose",
   "score": 10.409544944763184,
   "articlesIDs": [
    "17570705"
   ]
  },
  {
   "text": "patients with fa",
   "score": 10.396810531616211,
   "articlesIDs": [
    "34597127"
   ]
  },
  {
   "text": "presence of a germline p53 mutation",
   "score": 10.363672256469727,
   "articlesIDs": [
    "8839555"
   ]
  },
  {
   "text": "parents' marijuana and cocaine use",
   "score": 10.333120346069336,
   "articlesIDs": [
    "8318638"
   ]
  },
  {
   "text": "patients with rms",
   "score": 10.251583099365234,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "families of patients with rms",
   "score": 10.247270584106445,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "choroid plexus tumors (cpts)",
   "score": 10.246345520019531,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "low-dose etoposide in addition to that assumed for cyclophosphamide",
   "score": 10.206192016601562,
   "articlesIDs": [
    "8202048"
   ]
  },
  {
   "text": "rhabdomyosarcoma survivors",
   "score": 10.176347732543945,
   "articlesIDs": [
    "28822326"
   ]
  },
  {
   "text": "female sex, age \u003c70 years, or having a synovial sarcoma or chordoma",
   "score": 10.138097763061523,
   "articlesIDs": [
    "33002193"
   ]
  },
  {
   "text": "nf",
   "score": 10.12955093383789,
   "articlesIDs": [
    "3155239"
   ]
  },
  {
   "text": "fat mass and obesity-associated protein",
   "score": 10.094667434692383,
   "articlesIDs": [
    "33243845"
   ]
  },
  {
   "text": "youngest patients was higher for those with embryonal rhabdomyosarcoma",
   "score": 10.039647102355957,
   "articlesIDs": [
    "26193998"
   ]
  },
  {
   "text": "family history that suggested the li-fraumeni syndrome (lfs)",
   "score": 10.025616645812988,
   "articlesIDs": [
    "8426203"
   ]
  },
  {
   "text": "first-degree relative who was younger at diagnosis of cancer (\u003c30 years)",
   "score": 9.974888801574707,
   "articlesIDs": [
    "25809884"
   ]
  },
  {
   "text": "chemotherapy-sensitive",
   "score": 9.931477546691895,
   "articlesIDs": [
    "24752471"
   ]
  },
  {
   "text": "in young mothers of patients with rhabdomyosarcoma",
   "score": 9.89212417602539,
   "articlesIDs": [
    "8839555"
   ]
  },
  {
   "text": "mothers of children with soft tissue sarcoma",
   "score": 9.891984939575195,
   "articlesIDs": [
    "3224086"
   ]
  },
  {
   "text": "high tumor grade; positive regional nodes",
   "score": 9.869699478149414,
   "articlesIDs": [
    "3353622"
   ]
  },
  {
   "text": "lymph node metastasis",
   "score": 9.84048080444336,
   "articlesIDs": [
    "29529647"
   ]
  },
  {
   "text": "childhood adrenocortical tumors (acts)",
   "score": 9.830535888671875,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "\"other\" x-ray exposures",
   "score": 9.826594352722168,
   "articlesIDs": [
    "19293315"
   ]
  },
  {
   "text": "fancc",
   "score": 9.810351371765137,
   "articlesIDs": [
    "35512711"
   ]
  },
  {
   "text": "south asian ethnic origin",
   "score": 9.808143615722656,
   "articlesIDs": [
    "10755411"
   ]
  },
  {
   "text": "a history of retinoblastoma as the primary cancer",
   "score": 9.779464721679688,
   "articlesIDs": [
    "30053029"
   ]
  },
  {
   "text": "fanconi anemia (fa) and ataxia-telangiectasia (at)",
   "score": 9.776871681213379,
   "articlesIDs": [
    "34597127"
   ]
  },
  {
   "text": "younger age at diagnosis",
   "score": 9.776538848876953,
   "articlesIDs": [
    "17570705"
   ]
  },
  {
   "text": "c-x-c motif chemokine receptor type 4)",
   "score": 9.762937545776367,
   "articlesIDs": [
    "33243845"
   ]
  },
  {
   "text": "i171v germline mutation",
   "score": 9.752007484436035,
   "articlesIDs": [
    "21436738"
   ]
  },
  {
   "text": "patients with chemotherapy-sensitive",
   "score": 9.712800025939941,
   "articlesIDs": [
    "24752471"
   ]
  },
  {
   "text": "rhabdomyosarcoma in adolescent and young adult patients",
   "score": 9.702600479125977,
   "articlesIDs": [
    "33791777"
   ]
  },
  {
   "text": "embryonal rms) in children who have a first-degree relative with cancer",
   "score": 9.653167724609375,
   "articlesIDs": [
    "25809884"
   ]
  },
  {
   "text": "children with noonan (ns), cardio-facial-cutaneous, costello",
   "score": 9.59562873840332,
   "articlesIDs": [
    "20029231"
   ]
  },
  {
   "text": "neurofibromatosis themselves",
   "score": 9.477884292602539,
   "articlesIDs": [
    "8426203"
   ]
  },
  {
   "text": "childhood adrenocortical tumors (acts), choroid plexus tumors (cpts)",
   "score": 9.408287048339844,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "for people who had childhood rhabdomyosarcoma",
   "score": 9.400087356567383,
   "articlesIDs": [
    "31743457"
   ]
  },
  {
   "text": "age greater than 53",
   "score": 9.348450660705566,
   "articlesIDs": [
    "3353622"
   ]
  },
  {
   "text": "for children who had undergone both chemotherapy and radiotherapy",
   "score": 9.33108139038086,
   "articlesIDs": [
    "31743457"
   ]
  },
  {
   "text": "choroid plexus tumors (cpts), and rhabdomyosarcoma (rms)",
   "score": 9.323465347290039,
   "articlesIDs": [
    "22653678"
   ]
  },
  {
   "text": "patients receiving neither cyclophosphamide nor etoposide",
   "score": 9.283574104309082,
   "articlesIDs": [
    "8202048"
   ]
  },
  {
   "text": "neurofibromatosis type i (nf1)",
   "score": 9.260242462158203,
   "articlesIDs": [
    "8557179"
   ]
  },
  {
   "text": "all histologic types of childhood sts",
   "score": 9.22223949432373,
   "articlesIDs": [
    "15852362"
   ]
  },
  {
   "text": "proximal site; size greater than or equal to 10 cm; high tumor grade",
   "score": 9.199422836303711,
   "articlesIDs": [
    "3353622"
   ]
  },
  {
   "text": "benign thyroid disease",
   "score": 9.13007926940918,
   "articlesIDs": [
    "9295070"
   ]
  },
  {
   "text": "most relatives of patients with sts",
   "score": 9.11727237701416,
   "articlesIDs": [
    "8839555"
   ]
  },
  {
   "text": "age greater than 53; presentation with recurrent disease; high tumor grade",
   "score": 9.065872192382812,
   "articlesIDs": [
    "3353622"
   ]
  },
  {
   "text": "neurofibromatosis (nf)",
   "score": 9.035494804382324,
   "articlesIDs": [
    "3155239"
   ]
  },
  {
   "text": "patients who received both an alkylating agent and radiotherapy",
   "score": 9.033695220947266,
   "articlesIDs": [
    "8426203"
   ]
  },
  {
   "text": "high tumor grade; positive nodes; invasion of vital structures",
   "score": 9.006498336791992,
   "articlesIDs": [
    "3353622"
   ]
  },
  {
   "text": "liposarcoma, or rhabdomyosarcoma",
   "score": 8.968904495239258,
   "articlesIDs": [
    "33002193"
   ]
  },
  {
   "text": "children who are treated for soft tissue sarcoma (sts)",
   "score": 8.960872650146484,
   "articlesIDs": [
    "15852362"
   ]
  },
  {
   "text": "those of south asian ethnic origin",
   "score": 8.901357650756836,
   "articlesIDs": [
    "10755411"
   ]
  },
  {
   "text": "pediatric patient with dmd",
   "score": 8.878510475158691,
   "articlesIDs": [
    "34805447"
   ]
  },
  {
   "text": "non-hodgkin lymphoma (nhl) in 8, hodgkin disease (hd)",
   "score": 8.794645309448242,
   "articlesIDs": [
    "18989155"
   ]
  },
  {
   "text": "puberty with age differences between boys and girls",
   "score": 8.725133895874023,
   "articlesIDs": [
    "8333423"
   ]
  },
  {
   "text": "the youngest patients was higher for those with embryonal rhabdomyosarcoma",
   "score": 8.723165512084961,
   "articlesIDs": [
    "26193998"
   ]
  },
  {
   "text": "older age at presentation",
   "score": 8.697555541992188,
   "articlesIDs": [
    "28590782"
   ]
  },
  {
   "text": "rhabdomyosarcoma, clear cell sarcoma, epithelioid sarcoma",
   "score": 8.67194938659668,
   "articlesIDs": [
    "29529647"
   ]
  },
  {
   "text": "rs9937053 near (fat mass and obesity-associated protein",
   "score": 8.596776962280273,
   "articlesIDs": [
    "33243845"
   ]
  },
  {
   "text": "subtle genetic polymorphisms",
   "score": 8.569486618041992,
   "articlesIDs": [
    "12580371"
   ]
  },
  {
   "text": "noonan syndrome patients",
   "score": 8.554931640625,
   "articlesIDs": [
    "25742478",
    "8544198"
   ]
  },
  {
   "text": "childhood cancer survivors (ccss)",
   "score": 8.5072603225708,
   "articlesIDs": [
    "30053029"
   ]
  },
  {
   "text": "duchenne muscular dystrophy (dmd), caused by a mutation in the dmd gene",
   "score": 8.482176780700684,
   "articlesIDs": [
    "34805447"
   ]
  },
  {
   "text": "acute nonlymphoblastic leukemia (anll)",
   "score": 8.464868545532227,
   "articlesIDs": [
    "8426203"
   ]
  },
  {
   "text": "mothers of young children with soft tissue tumours",
   "score": 8.393187522888184,
   "articlesIDs": [
    "3348946"
   ]
  },
  {
   "text": "clear cell sarcoma, epithelioid sarcoma, and myxoid/round cell liposarcoma",
   "score": 8.376696586608887,
   "articlesIDs": [
    "29529647"
   ]
  },
  {
   "text": "third trimester",
   "score": 8.345250129699707,
   "articlesIDs": [
    "19293315"
   ]
  },
  {
   "text": "childhood soft tissue sarcoma (sts)",
   "score": 8.320440292358398,
   "articlesIDs": [
    "8839555"
   ]
  },
  {
   "text": "mutation carriers",
   "score": 8.254135131835938,
   "articlesIDs": [
    "20522432"
   ]
  },
  {
   "text": "rs185932673 near (calcium/calmodulin-dependent protein kinase id)",
   "score": 8.236124038696289,
   "articlesIDs": [
    "33243845"
   ]
  },
  {
   "text": "skin in the area of malformations",
   "score": 8.227054595947266,
   "articlesIDs": [
    "31045469"
   ]
  }
 ]
}