Datasets:

enoriega

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biocreative_gene_mention

like 1

[ "The", "dominant", "negative", "mutant", "of", "SHP-2", "was", "found", "to", "inhibit", "the", "induction", "of", "tyrosine", "phosphorylation", "and", "DNA", "binding", "activity", "of", "m-Stat5a", ",", "m-Stat5b", ",", "and", "the", "carboxyl-terminal", "deletion", "variant", "m-Stat5adelta749", ",", "as", "well", "as", "the", "transactivation", "potential", "of", "m-Stat5a", "and", "m-Stat5b", "." ]

[ "the", "dominant", "negative", "mutant", "of", "shp-2", "be", "find", "to", "inhibit", "the", "induction", "of", "tyrosine", "phosphorylation", "and", "dna", "binding", "activity", "of", "m-stat5a", ",", "m-stat5b", ",", "and", "the", "carboxyl-terminal", "deletion", "variant", "m-stat5adelta749", ",", "as", "well", "as", "the", "transactivation", "potential", "of", "m-stat5a", "and", "m-stat5b", "." ]

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[ "Sites", "1", "and", "4", "in", "lumican", "and", "keratocan", "are", "in", "a", "homologous", "location", "." ]

[ "site", "1", "and", "4", "in", "lumican", "and", "keratocan", "be", "in", "a", "homologous", "location", "." ]

[ 35, 39, 30, 39, 20, 7, 30, 7, 10, 20, 2, 8, 7, 15 ]

[ 2, 2, 2, 2, 2, 0, 2, 0, 2, 2, 2, 2, 2, 2 ]

[ "Our", "observations", "suggest", "that", "members", "of", "the", "HMG-I", "family", "play", "an", "important", "role", "in", "SRF", "dependent", "transcription", "and", "that", "their", "effect", "is", "mediated", "primarily", "by", "a", "protein", "protein", "interaction", "." ]

[ "we", "observation", "suggest", "that", "member", "of", "the", "hmg-i", "family", "play", "a", "important", "role", "in", "srf", "dependent", "transcription", "and", "that", "they", "effect", "be", "mediate", "primarily", "by", "a", "protein", "protein", "interaction", "." ]

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[ 2, 2, 2, 2, 2, 2, 2, 0, 1, 2, 2, 2, 2, 2, 0, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2 ]

[ "ATP", "dependent", "assembly", "of", "a", "ternary", "complex", "consisting", "of", "a", "DNA", "mismatch", "and", "the", "yeast", "MSH2-MSH6", "and", "MLH1-PMS1", "protein", "complexes", "." ]

[ "atp", "dependent", "assembly", "of", "a", "ternary", "complex", "consist", "of", "a", "dna", "mismatch", "and", "the", "yeast", "msh2-msh6", "and", "mlh1-pms1", "protein", "complex", "." ]

[ 7, 8, 7, 20, 2, 8, 7, 14, 20, 2, 7, 7, 30, 2, 7, 7, 30, 7, 7, 35, 15 ]

[ 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 2, 0, 2, 2, 2 ]

[ "Mutation", "of", "the", "central", "Tyr497", "to", "Phe", "blocks", "the", "tyrosine", "phosphorylation", "of", "the", "insulin", "receptor", "substrate", "1", "(", "IRS1", ")", "and", "diminishes", "proliferation", "in", "response", "to", "IL-4", "." ]

[ "mutation", "of", "the", "central", "tyr497", "to", "phe", "block", "the", "tyrosine", "phosphorylation", "of", "the", "insulin", "receptor", "substrate", "1", "(", "irs1", ")", "and", "diminish", "proliferation", "in", "response", "to", "il-4", "." ]

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[ 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 1, 1, 1, 2, 0, 2, 2, 2, 2, 2, 2, 2, 0, 2 ]

[ "Instead", ",", "it", "contained", "two", "tandem", "kappaB", "elements", "and", "a", "variant", "activating", "transcription", "factor", "/", "cAMP", "response", "element", "site", ",", "which", "closely", "resembled", "sites", "in", "the", "E-selectin", "gene", "that", "are", "required", "for", "TNF-alpha-", "or", "LPS", "inducible", "expression", "." ]

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[ "We", "recently", "characterized", "a", "single", "yeast", "hnRNP", "methyltransferase", "(", "HMT1", ")", "." ]

[ "we", "recently", "characterize", "a", "single", "yeast", "hnrnp", "methyltransferase", "(", "hmt1", ")", "." ]

[ 18, 26, 21, 2, 8, 7, 7, 7, 39, 7, 7, 15 ]

[ 2, 2, 2, 2, 2, 0, 1, 1, 2, 0, 2, 2 ]

[ "We", "recently", "characterized", "a", "single", "yeast", "hnRNP", "methyltransferase", "(", "HMT1", ")", "." ]

[ "we", "recently", "characterize", "a", "single", "yeast", "hnrnp", "methyltransferase", "(", "hmt1", ")", "." ]

[ 18, 26, 21, 2, 8, 7, 7, 7, 39, 7, 7, 15 ]

[ 2, 2, 2, 2, 2, 0, 1, 1, 2, 0, 2, 2 ]

[ "Recombinant", "HRMT1L2", "protein", "encoded", "by", "the", "most", "common", "5", "'", "-", "variant", "exhibited", "methyltransferase", "activity", "in", "vitro", "." ]

[ "recombinant", "hrmt1l2", "protein", "encode", "by", "the", "most", "common", "5", "'", "-", "variant", "exhibit", "methyltransferase", "activity", "in", "vitro", "." ]

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[ 0, 1, 1, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2 ]

[ "The", "possible", "roles", "of", "HRMT1L1", "and", "HRMT1L2", "in", "human", "disease", "are", "currently", "unknown", "." ]

[ "the", "possible", "role", "of", "hrmt1l1", "and", "hrmt1l2", "in", "human", "disease", "be", "currently", "unknown", "." ]

[ 2, 8, 35, 20, 7, 30, 7, 20, 8, 7, 10, 26, 8, 15 ]

[ 2, 2, 2, 2, 0, 2, 0, 2, 2, 2, 2, 2, 2, 2 ]

[ "Identification", "and", "characterization", "of", "two", "putative", "human", "arginine", "methyltransferases", "(", "HRMT1L1", "and", "HRMT1L2", ")", "." ]

[ "identification", "and", "characterization", "of", "two", "putative", "human", "arginine", "methyltransferase", "(", "hrmt1l1", "and", "hrmt1l2", ")", "." ]

[ 7, 30, 7, 20, 39, 8, 8, 7, 35, 10, 7, 30, 7, 7, 15 ]

[ 2, 2, 2, 2, 2, 2, 0, 1, 1, 2, 0, 2, 0, 2, 2 ]

[ "Interestingly", ",", "the", "activated", "PDGF", "beta-receptor", "was", "found", "not", "to", "bind", "Crk", "proteins", "." ]

[ "interestingly", ",", "the", "activate", "pdgf", "beta-receptor", "be", "find", "not", "to", "bind", "crk", "protein", "." ]

[ 26, 16, 2, 28, 7, 7, 21, 28, 26, 24, 22, 7, 35, 15 ]

[ 2, 2, 2, 2, 0, 1, 2, 2, 2, 2, 2, 0, 1, 2 ]

[ "Furthermore", ",", "interactions", "were", "identified", "between", "endogenous", "E-cadherin", "and", "the", "chimera", "containing", "the", "E-cadherin", "extracellular", "domain", "and", "the", "desmoglein", "1", "intracellular", "domain", "providing", "in", "vivo", "evidence", "for", "previously", "predicted", "lateral", "interactions", "of", "E-cadherin", "extracellular", "domains", "." ]

[ "furthermore", ",", "interaction", "be", "identify", "between", "endogenous", "e-cadherin", "and", "the", "chimera", "contain", "the", "e-cadherin", "extracellular", "domain", "and", "the", "desmoglein", "1", "intracellular", "domain", "provide", "in", "vivo", "evidence", "for", "previously", "predict", "lateral", "interaction", "of", "e-cadherin", "extracellular", "domain", "." ]

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[ "In", "addition", "to", "a", "previously", "characterized", "promoter", "(", "P1", ")", ",", "we", "now", "show", "the", "existence", "of", "a", "second", "promoter", "for", "the", "human", "IL-5Ralpha", "gene", "." ]

[ "in", "addition", "to", "a", "previously", "characterize", "promoter", "(", "p1", ")", ",", "we", "now", "show", "the", "existence", "of", "a", "second", "promoter", "for", "the", "human", "il-5ralpha", "gene", "." ]

[ 20, 7, 24, 2, 26, 28, 7, 39, 7, 7, 16, 18, 26, 10, 2, 7, 20, 2, 8, 7, 20, 2, 8, 7, 7, 15 ]

[ 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 1, 1, 2 ]

[ "Their", "use", "resulted", "in", "a", "sensitivity", "of", "73", "%", "and", "a", "specificity", "of", "74", "%", "with", "regard", "to", "predictability", "of", "ALT", "levels", "increasing", "during", "the", "trial", "." ]

[ "they", "use", "result", "in", "a", "sensitivity", "of", "73", "%", "and", "a", "specificity", "of", "74", "%", "with", "regard", "to", "predictability", "of", "alt", "level", "increase", "during", "the", "trial", "." ]

[ 17, 7, 21, 20, 2, 7, 20, 39, 7, 30, 2, 7, 20, 39, 7, 20, 7, 24, 7, 20, 7, 35, 14, 20, 2, 7, 15 ]

[ 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 2, 2, 2, 2, 2, 2 ]

[ "To", "study", "retinoid", "signalling", "in", "zebrafish", "embryos", ",", "we", "developed", "a", "novel", "method", "to", "detect", "endogenous", "retinoids", "in", "situ", "in", "embryos", ",", "using", "a", "fusion", "protein", "of", "the", "ligand", "inducible", "transactivation", "domain", "of", "a", "retinoic", "acid", "receptor", "and", "a", "heterologous", "DNA", "binding", "domain", "." ]

[ "to", "study", "retinoid", "signalling", "in", "zebrafish", "embryo", ",", "we", "develop", "a", "novel", "method", "to", "detect", "endogenous", "retinoid", "in", "situ", "in", "embryo", ",", "use", "a", "fusion", "protein", "of", "the", "ligand", "inducible", "transactivation", "domain", "of", "a", "retinoic", "acid", "receptor", "and", "a", "heterologous", "dna", "binding", "domain", "." ]

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[ "To", "identify", "nuclear", "regulatory", "factors", ",", "we", "have", "located", "and", "functionally", "characterized", "the", "CCR5", "gene", "promoter", "." ]

[ "to", "identify", "nuclear", "regulatory", "factor", ",", "we", "have", "locate", "and", "functionally", "characterize", "the", "ccr5", "gene", "promoter", "." ]

[ 24, 22, 8, 8, 35, 16, 18, 10, 28, 30, 26, 21, 2, 7, 7, 7, 15 ]

[ 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 1, 1, 2 ]

[ "Fluorescence", "in", "situ", "hybridization", "of", "metaphase", "spreads", "of", "chromosome", "8", ",", "containing", "hybrid", "cell", "line", "706-B6", "clone", "17", "(", "CL-17", ")", "with", "cosmid", "c101F1", ",", "placed", "the", "9804", "gene", "close", "to", "the", "telomere", "at", "8q24", ".3", "." ]

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[ "Cell", "survival", "by", "Epo", "did", "not", "require", "activation", "of", "other", "known", "signaling", "pathways", "including", "PI-3", "kinase", ",", "PLC-gamma", ",", "Ras", "or", "Stats", "." ]

[ "cell", "survival", "by", "epo", "do", "not", "require", "activation", "of", "other", "known", "signaling", "pathway", "include", "pi-3", "kinase", ",", "plc-gamma", ",", "ra", "or", "stats", "." ]

[ 7, 7, 20, 7, 21, 26, 22, 7, 20, 8, 8, 7, 35, 14, 7, 7, 16, 7, 16, 7, 30, 35, 15 ]

[ 2, 2, 2, 0, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 1, 2, 0, 2, 0, 2, 0, 2 ]

[ "The", "N-syndecan", "dependent", "neurite", "outgrowth", "is", "inhibited", "by", "the", "tyrosine", "kinase", "inhibitors", "herbimycin", "A", "and", "PP1", "." ]

[ "the", "n-syndecan", "dependent", "neurite", "outgrowth", "be", "inhibit", "by", "the", "tyrosine", "kinase", "inhibitor", "herbimycin", "a", "and", "pp1", "." ]

[ 2, 7, 8, 7, 7, 9, 28, 20, 2, 7, 7, 35, 7, 7, 30, 7, 15 ]

[ 2, 2, 2, 2, 2, 2, 2, 2, 2, 0, 1, 2, 2, 2, 2, 0, 2 ]

[ "An", "in", "vivo", "ZAP-70", "substrate", ",", "SLP-76", ",", "implicated", "in", "Erk", "activation", ",", "also", "became", "rapidly", "tyrosine", "phosphorylated", "in", "Jurkat", "cells", ",", "but", "not", "in", "P116", "cells", ",", "upon", "treatment", "with", "H2O2", "." ]

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