sentence: Data obtained in mouse models were similar to those seen in patients with HD , as plasma levels of several inflammatory molecules , including IL-6 , IL-8 , TNF - α , IL-10 , IL-1 β , and IL-12p70 , were elevated in the HD mouse models R6 / 2 , HdhQ150 ( murine model expressing 150 CAG repeats inserted in the mouse endogenous HTT gene first exon ) , and YAC128 [ 8, 12 , 42 ] .