sentence: This model system is very successful and widely applied , as it displays the age-dependent loss of locomotor function , the degeneration of DA neurons and LB-like inclusions , features that are present in human PD ( Auluck et al ., 2002 ; Botella et al ., 2009 ; B ü ttner et al ., 2014 ; Feany & Bender , 2000 ; Kong et al ., 2015 ; Staveley , 2014 ; Webb et al ., 2003 ; Zhu et al ., 2016 ) .