sentence: Furthermore , DNA replication licensing factor MCM2 , nucleosome assembly protein 1-like 4 ( NAP1L4 ) , serine / arginine-rich splicing factor 11 ( SRSF11 ) , and DNA topoisomerase 2-alpha ( TOP2A ) were also inhibited after treatment with CIGB-300 , although the downregulated phospho-residue was different in each AML cell line ( Table 1 , Table S6 ) .