sentence: Because multinucleotide mutations ( MNMs ) can cause false inferences of positive selection in the PAML BS test ( Venkat et al. 2017 ) , for all significant genes we further applied a more conservative BS model ( BS + MNM ) ( Venkat et al. 2017 ) in which another parameter δ is incorporated to represent the relative instantaneous rate of double mutations to that of single mutations ( Venkat et al. 2017 ) .