sentence: They also demonstrated that the initial effect of the agonist is to pull the bottom part of VFD3 / TAS1R3 toward the bottom part of VFD2 / TAS1R2 by ~ 6 Å and that these changes get transmitted from VFD2 of TAS1R2 ( where agonists bind ) through the VFD3 and the CRD3 to the TMD3 of TAS1R3 ( which couples to the G protein ) [ 113 ] .