sentence: Since LPA is a key downstream mediator of autotaxin pathway , this discovery , together with the available direct autotaxin lysophospholipase D inhibitors , expand the list of chemical probes to dissect the roles of the autotaxin pathway in mesothelial biology.Highly invasive visceral cells were treated with these new compounds and the known autotaxin inhibitor S32826 in Boyden chamber analysis .