sentence: Beyond functioning as a tumor suppressor , accumulating evidence have more recently indicated that Cav-1 , especially when phosphorylated in Tyr14 , behaves as an ambiguous partner in cancer [ 11 ] – [ 15 ] , because of its ability to activate pathways involved in cell migration and invasion , such as the Rho / ROCK and Focal adhesion kinases signaling systems [ 62 ] .