sentence: Four classification models were generated based on the qRT-PCR gene expression patterns of fifteen genes , the eleven significant genes plus four genes that were members of the Hedgehog signaling pathway or were selected in the fold-change analysis of both the RMA and PLIER normalized data sets : GLI3 , HHIP , RAN binding protein 3-like ( RANBP3L ) and peptidoglycan recognition protein 1 ( PGLYRP1 ) .