sentence: In the case of the SN3 fraction , we found that GFP-RRP12 interacts with the 21S pre-rRNA ( Fig. 6a , bottom panel , lane 10 ) , the 18S-E pre-rRNA ( Fig. 6a , bottom panel , lane 10 ) , NOC4L ( Fig. 6b , second panel from top , lane 12 ) and ENP1 ( Fig. 6b , third panel from top , lane 12 ) .