sentence: This line of research has been initiated with the detection of interactions between ANKS6 and the RNA binding protein BICC1 , which have shed light on BICC1 mediated mechanisms ( cell polarity , cAMP signaling , cilia orientation and cilia-driven-fluid flow ) that may be involved in renal cystogenesis when interaction between BICC1 and ANKS6 is affected [ 7 – 9 ] .