sentence: It is also significant that we obtained analogous results in a transgenic model and an acute pharmacological model ; this suggests that the heightened light sensitivity of the Grm2 / 3 mouse is not a consequence of altered neurodevelopment.Collectively , these results demonstrate that mGlu2 and / or mGlu3 can modulate the sensitivity of the circadian system to light , which raises the possibility that mGlu2 / 3-targeting compounds may be useful for the treatment of circadian rhythm disorders .