sentence: Regarding the NOX-A12 spiegelmer , previous clinical experience showed safe application of high-dose NOX-A12 in intermittent intervals31 37 leading to the OPERA trial design.Indeed , similarly to the two aforementioned studies , the overall treatment with either NOX-A12 as monotherapy or the combination with pembrolizumab was very well tolerated , even by patients who had more than four previous lines of chemotherapy .