sentence: Since positive interactions were found with the Sbh1-CPLV and Sbh2-CPLV fusion proteins , and the interacting Nub-fusions were located in the cytosol , adding CPLV to the C-terminus of Sbh1p and Sbh2p must have inverted their topology in the ER membrane , and it remains therefore unclear whether the interactions found with these fusion proteins are meaningful .