sentence: Based on this evidence , HSV-1 UL46 disrupts the cGAS-STING signaling pathway and possibly interacts with both STING and TBK1 via separate domains.An increasing amount of evidence has shown that post-translational modifications , such as phosphorylation and ubiquitination , directly or indirectly modulate the cGAS / STING pathway and significantly affect viral infections ( Liu et al ., 2013 , 2016 ) .