sentence: 46 In agreement with previous results that showed that AIT with Dermatophagoides species was unable to induce a cross-desensitization effect towards Blomia tropicalis , present results have shown that Blomia AIT has no effect on skin reactivity towards D. pteronyssinus or D. siboney in patients that had polysensitization , which is in line with the scarce cross-reactivity reported between Blomia and Dermatophagoides extracts as well as with the marked difference in the allergen profile.6 15 , 16 , 17 40 41 45 47Despite the beneficial aspects of AIT , safety of injection route has been a major concern , since severe systemic reactions can pose a life-threatening risk .