sentence: The above underline the necessity and importance of these cell cycle genes in the proliferation of cancer cells.Taking the above into consideration , as well as the very low expression levels of WHSC1L1 in normal tissues [ 19 ] , WHSC1L1 may serve as a promising candidate for drug development for patients with SCCHN as well as other cancer types characterized by WHSC1L1 amplification or overexpression .