sentence: The complex association pattern of the DXA area variants with height , BMD , osteoarthritis and fractures may reflect different aspects of bone biology , such as differences between longitudinal and radial growth , or between trabecular and cortical compartments of the bones , the mineralization process , modeling and remodeling , and the periosteal expansion observed with age.Finally , we show through overexpression in HEK293T cell line that the variant in MIR196A2 , that associates with both decreased lumbar spine area and increased risk of hip fracture , directly influences repression of miR-196a-5p target genes , with the fracture associating allele , rs11614913 [ T ] , being less effective than the rs11614913 [ C ] allele .