sentence: 20-HETE is an eicosanoid metabolite of arachidonic acid , which is produced by cytochrome P450-dependent ω - hydroxylases of the CYP4 and CYP2 families , including CYP4A11 , CYP4A22 , CYP4F2 , CYP4F3 , CYP4V2 , and CYP2U1 in humans and Cyp4a10 , Cyp4a12 , Cyp4f13 , Cyp4f16 , Cyp4v3 , and Cyp2u1 in mice .