sentence: This review summarizes the state-of-the-art , and critically discusses the limits and possible advantages of drug discovery research from the deep sea.Currently , there are fourteen ( 13 Food and Drug Administration ( FDA ) - approved drugs and one Australia drug approved in 2018 ) pharmaceutical products in clinical use , of which nine are used for different cancer treatments ( Cytosar-U , Halaven , Adcetris , Yondelis , Aplidin , Polivy , PADCEV , Zepzelca and Blenrep ) , three for hypertriglyceridemia ( Lovaza , Vascepa and Epanova ) , one for severe chronic pain ( Prialt ) and one as antiviral ( Vira-A ) , against herpes simplex virus ( https://www.midwestern.edu/departments/marinepharmacology/clinical-pipeline , accessed on 12 October 2021 ) .