sentence: There is strong evidence that miRNA fine-tune translation locally at activated synapses ( Schratt et al ., 2006 ; Bredy et al ., 2011 ) : miR-134-5p inhibits translation of Limk1 at the synapse until synaptic activation , at which point miR-134-5p is inactivated and Limk1 protein is expressed , leading to dendritic spine growth .