sentence: Spectraplakins are multifunctional cytoskeletal linker proteins characterized by an N-terminal actin binding domain consisting of Calponin homology domains , a globular plakin domain that mediates interactions with various types of cell junctions , a plakin repeat domain that can interact with intermediate filaments , a spectrin repeat domain that allows dimerization , and finally a C-terminal microtubule binding domain that consists of an EF-hand and GAS2 domain [ 23 ] , [ 24 ] .