sentence: Taken together with the above-mentioned reports and present study , it may suggest that PAFr activates the signaling cascades that is independent of p38 MAPK and involved in the production of proinflammatory cytokines after peripheral nerve injury.In the present study , findings that SNI surgery induced upregulation of LPCAT2 and PAFr in spinal microglia and intrathecal injection of PAFr antagonist ( WEB2086 ) significantly suppressed the development of mechanical allodynia suggested an intraspinal role of PAF in neuropathic pain .