sentence: Activated Fus3 and Kss1 phosphorylate cytoplasmic and cell membrane – tethered targets , including Ste18 and Far1 , to promote cell cycle arrest and translocate into the nucleus , activating a specific transcriptional program.Polarized growth toward the mating partner and the subsequent cell – cell fusion events require spatial cell wall remodeling that renders cells vulnerable to lysis ( Zarzov et al ., 1996 ) .