sentence: Nevertheless , prolonged BMP6 application caused peritoneal calcifications , indicative of lack of target specificity , which may lead to further pleiotropic side effects.Cell culture studies and chemical screens identified several small molecules capable of stimulating hepcidin transcription in vitro , such as genistein ( Zhen et al ., 2013 ) , SB204741 , daunorubicin , ethacridine , phenazopyridine , 9-aminoacridine , amlexanox , lansoprazole , leflunomide , ipriflavone , AS252424 , pterostilbene , AG1296 , GTP14564 , SU6668 , leflunomide , 10058-F4 and vorinostat ( Gaun et al ., 2014 ) .