sentence: Although single neuron recordings ( microwire electrodes ) would be ideal to investigate underlying cellular mechanisms , our data provide some hints to this regard : scalp ripples and spikes possibly reflect distinct pathophysiological mechanisms generated by different epileptogenic networks ( as demonstrated on icEEG ) ,3 , 54 whose activation is not independent to each other , but may be facilitated by a common brain state.55 , 56 We also acknowledge that the use of different localization methods ( dipoles vs. wMEM ) may confound the localization comparison between spike and ripple generators ; yet , we believe that their presence on different sensors strongly supports the hypothesis of two different active sources.52 Spike localization via the coherent MEM57 , 58 may cancel the aforesaid confounding factor ; yet , we chose dipole modeling , being the only clinically approved method , in order to facilitate clinical translation of our findings .