sentence: However , further work will be required to resolve the details of how p75NTR , proNGF and SorCS2 interact in a ternary complex.Members of the VPS10p family have been shown to play an important role in synaptic plasticity and have been associated with neurodegenerative diseases such as Alzheimer ’ s , frontotemporal lobar degeneration and Huntington ’ s , and psychological disorders such as schizophrenia , bipolar disorders , and attention-deficit hyperactivity disorder .