sentence: Biological networks , though being less detailed in information than pathways , are nevertheless useful for analyzing and visualizing - omics data.The most popular tools for network analysis are Cytoscape36 and Gephi.37 Both are open source and aid network exploration , manipulation , and analysis by providing filtering , layout , coloring , and clustering capabilities.Cytoscape ’ s network analysis package38 and Gephi facilitate network analysis by calculating complex network parameters like average clustering coefficients , shortest paths , and node degrees , as well as centrality measures like stress centrality ,39,40 betweenness centrality ,39 and closeness centrality .