sentence: The concept of dual bronchodilation with combination short-acting bronchodilators is well recognized , eg , the β agonist and antimuscarinic combination inhaler containing ipratropium bromide-albuterol ( Combivent ) , which has been in use for many years.7 For long-acting agents , a number of trials have assessed coprescribing of LABA and LAMA in separate inhalers.8 Generally , these trials , conducted using tiotropium coprescribed with a number of LABAs , consistently found a greater effect on lung function with the combination than with single agents , with some benefit in patient-reported outcomes and no safety concerns apparent.8 – 10An important issue for both regulators and practicing clinicians is to understand any benefit of coadministration of a LAMA-LABA as the fixed-dose combination over LAMA monotherapy .