sentence: Based on these differences , the WxL1 and WxL2 domains can be distinguished as different domain variants , which is also supported by Hidden Markov Models : CscB proteins were recognized by a Hidden Markov model based on the WxL1 domain without false positive hits in CscC proteins , and vice versa.In addition , other domains could be identified in some CscC proteins with homology to different kinds of binding domains , albeit often with weak homology ( see additional file 4 ) .