sentence: Finally , evidence of BICC1-mediated regulation of renal cAMP signaling in Bicc1 mutant mice [ 9 ] suggests a synergistic biological role of BICC1 , ANKS6 and ANKS3 in regulating vasopressin / cAMP signaling processes.Renal gene transcription profiling data in other models of PKD and in humans also support our observations and suggest that altered vasopressin-mediated mechanisms may be a consensus feature in PKD pathophysiology .