sentence: IHC scoring revealed moderate or strong nuclear staining ( +2 , +3 ) in 58 % of SCCHN samples , and absent or weak ( 0 , +1 ) staining in 42 % of the samples , while 74 % of the normal epithelium samples stained weakly for WHSC1L1.Given that WHSC1 was also reported to be significantly overexpressed in SCCHN [ 14 ] , we assessed the correlation between expression levels of WHSC1L1 and WHSC1 in SCCHN samples and found them to be only mildly correlated ( Spearman correlation co-efficient ρ =0 .37 , P < 0.001 ) , suggesting that WHSC1 and WHSC1L1 may function as independent drivers of SCCHN oncogenesis.We then proceeded to assess correlations of WHSC1L1 expression with various clinicopathological parameters , such as overall and progression-free survival , age , gender , primary site , tumor size ( T ) , nodal stage ( N ) , TNM stage , grade , smoking history and human papilloma virus status in SCCHN patients with local or locoregionally advanced disease who were treated with either surgery with or without adjuvant chemoradiation , or definitive chemoradiation .