sentence: On the rise of attention in the genetic basis of diseases , the amount of genomic deoxyribonucleic acid ( DNA ) available from biological samples might be limit the genomic analysis practicality.1 Molecular diagnostics of human diseases can be classified into three major areas : Pathogen detection , mutation detection , and detecting the alterations in human genes that modify their functions or expression levels.2Getting the genomic DNA from fresh or frozen tissues is required for analyses.3 Pursuant to the collections of paraffin samples in pathology institutes around the world as archives of genetic material , could provide much useful genetic information.4Investigating DNA of materials stashed as formalin-fixed , paraffin embedded tissue ( FFPET ) sections in pathology laboratories has been increasingly practical to meet the requirement of rapid development of molecular morphology .