sentence: Notably , germline mutations in BPIFB1 ( rs6141383 , p.V284M ) , CHD4 ( rs74790047 , p.D140E ) , PARP1 ( rs3219145 , p.K940R ) , NUDT1 ( rs4866 , p.V83M ) , RAD52 ( rs4987207 , p.S346 * ) and MFI2 ( rs17129219 , p.A559T ) were significantly enriched in the young group when compared with the in ‐ house noncancer database ( p < 0.05 ) .