sentence: The effect of cilostazol on ADAM10 expression could be antagonized by sirtinol and by Sirtuin 1 ( SIRT1 ) - gene silencing , suggesting that RARbeta and this class of deacetlyase together act on the ADAM10 promoter.For a systematic approach on transcription factors relevant to ADAM10 regulation , we performed a screening approach ( Reinhardt et al ., 2014 ) .