sentence: Using a median cut-off , patients were stratified into low and high-risk groups and Kaplan − Meier ( KM ) plots were generated , as shown in Figure 2A , B. Specifically , the group characterized by low SCCHN TMI had significantly better survival outcomes.Univariable and multivariable Cox regression analyses were performed to adjust for confounding factors such as age and gender , history of cigarette smoke and alcohol consumption , and pathological tumor ( T ) stage ( according to AJCC version 8) , as shown in Figure S3 .