sentence: It has been previously reported that cytosplasmic proteins such as heat shock protein 70 ( HSP70 ) , aldo-keto reductase family 1 member B8 ( AKR1B8 ) , and AKR1B10 are released in the extracellular space via secretory lysosomes ( Mambula and Calderwood , 2006 ; Luo et al ., 2011 ; Tang et al ., 2014 ) .