sentence: Interestingly the amino acid residue at position 312 in the C57BL / 6J strain was predicted to be damaging ( SIFT functional polymorphism prediction program ) , suggesting that the Ica1 allele in DBA / 2J mice may enhance virus replication.Finally , Col28a1 is a von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain [ 37 ] .