sentence: Importantly , however , compounds with previously documented in vivo or in vitro leishmanicidal activity were also identified using the HILCES system , including pentamidine isothionate , clotrimazole , aminacrine , aphidicolin , and acivicin , thus further validating our assay system ( Table 1 and Table S1 ) [ 1 ] , [ 42 ] , [ 58 ] , [ 63 ] , [ 64 ] .