sentence: Our results suggest that prior to ever receiving an immune suppressive regimen , patients who later become viremic demonstrate a T-cell profile associated with immune senescence.Our analysis of clinical and experimental factors associated with BKPyV reactivation and viremia identified markers of increased immune suppression , such as the presence of diabetes mellitus or GN , conditions associated with immune dysfunction or immune dysregulation [ 42 – 45 ] , as the cause of renal failure , and of immune senescence , such as lower proportions of CD4 T-cells and higher proportions of CD8 T-cells .