sentence: These results suggest that AMPK mediates iron chelation-induced mTORC1 inhibition by AMPK-raptor / PRAS40 and AMPK-TSC pathways.Furthermore , we noticed that inhibition of AMPK with Compound C not only blocked 24-h iron chelation-induced p-raptor ( S792 ) ( Fig. 6a ) and p-TSC2 ( S1387 ) ( Fig. 7c , d ) , but also suppressed 24-h iron chelation-induced Bnip3 ( Fig. 6a ) and 5-h iron chelation-induced REDD1 ( Fig. S4H ) .