sentence: Despite its highly invasive nature , DBS led to significant improvements in the quality of life of patients with advanced PD and consists of the direct electrostimulation of the subthalamic nucleus ( STN ) or the GPi that are hyperactivated due to the decrease in midbrain dopaminergic neurons.In general , among PD patients , before surgery , women with PD use lower doses of dopaminergic medication and experienced more dyskinesias , mobility limitations , and sensory symptoms than men ( Hariz et al ., 2013 ) .