sentence: The latter can phosphorylate IRS-1 at several serine residues , including S302 and S632 / 635 ( Haruta et al ., 2000 ; Ozes et al ., 2001 ; Ueno et al ., 2005 ; Werner et al ., 2004 ) , which promotes IRS-1 degradation via proteasomes ( Pederson et al ., 2001 ; Sun et al ., 1999 ; Takano et al ., 2001 ) .