sentence: On review of literature no study was found evaluating the VEGF expression in the case of KCOT transforming into SCC , moreover , only 15 reports of SCC developing from KCOT have been reported.VEGF has been implicated in the pathogenesis of odontogenic tumors and cysts , while acquisition of anangiogenic phenotype appears to be a crucial aspect in the transition from hyperplasia to neoplasia and VEGF has also been found to be produced by tumor cells .