sentence: The abundances of these transcripts were also elevated in xrn4 mutants in the polyA - RNA-seq data with an average fold change of ≥ 2 , indicating that these mRNAs prefer to undergo deadenylation prior to 5 ′ to 3 ′ decay.Among the AUX / IAA family members , IAA2 previously identified as a Gene with Unstable Transcript ( GUT , ( 100 ) ) , and SHY2 / IAA3 strongly overaccumulated decapped intermediates in xrn4 mutants in polyA - PARE and total RNA , with a modest increase in capped RNA in the latter ( Figures 3A and 7D ; Supplementary Dataset S2 ) .