sentence: Taken together , these data indicate that the DdBasic domain of NKAP is responsible for a direct interaction and that it preferentially interacts with the Prp19-like domain and a domain containing amino acids 134 – 264 of Prp19.Since Prp19 is a member of the Ubox family of E3 ubiquitin ligases , the significance of the DdNKAP and Prp19 interaction could be ubiquitination of DdNKAP .