sentence: α - Syn , a neuronal intrinsically disordered protein implicated in Parkinson ’ s disease pathology , effectively blocks VDAC1 ( Rostovtseva et al ., 2015 ; Hoogerheide et al ., 2017 ; Jacobs et al ., 2019 ) , where the negatively charged C-terminus of α - syn forms a functional interaction with the positively charged pore of VDAC1 .