sentence: For both isoforms , the conductance of α - syn – blocked state is equivalent at ∼ 0.4 of the open-state conductance.The striking difference between hVDAC3 and mVDAC1 is in the frequency of α - syn – induced blockage events , where 10 nM of α - syn induces orders of magnitude fewer blockage events in hVDAC3 compared with mVDAC1 ( Fig. 5 A ) .