sentence: In addition , we found that Becn1 heterozygous KO mice have reduced serum adiponectin compared with WT littermates ( Figure 2C ) , further supporting the role of Becn1 in the regulation of circulating adiponectin levels.Adiponectin exists in the circulation as different multimer complexes , categorized as high-molecular-weight ( HMW ) multimers , medium-molecular-weight ( MMW ) hexamers , and low-molecular-weight ( LMW ) trimers , with the HMW adiponectin being the most biologically active form ( Basu et al ., 2007 ; Lara-Castro et al ., 2006 ; Murdolo et al ., 2009 ; Pajvani et al ., 2004 ) .