sentence: Genes corresponding to these loci are involved in the key pathogenesis pathways including : epidermal differentiation pathway ( LCE3B , LCE3C ) , IL-12 / IL-23 pathway ( IL12 , IL23A , IL23R , TRAF3IP2 , TYK2 ) , NF κ B and IFN signaling pathway ( TNFAIP3 , TNIP1 , NFKBIA , REL , TYK2 , IFIH1 , IL23RA ) , Th2 pathway ( IL4 , IL13 ) and adaptive immunity involving CD8 T cells ( ERAP1 , ZAP70 ) [ 11 ] .