sentence: Together , we suggest that nuclear shape changes due to the overexpression of Kuk or LaminDm0 Δ N are independent of filament formation and might also be related to altered chromatin – NM interactions.The hypothesis for a lamina-independent activity of Kuk is consistent with the results of our RNAi experiment that indicate that localization of Kuk and lamin Dm0 does not depend on other known INM proteins .