SPOKANE, Wash. — Four members of a Polish death metal band arrested on charges of kidnapping a Washington state woman are also suspected of sexually assaulting her after a concert during a party on the band's tour bus, according to court documents. The documents made public Monday said the assault by the members of Decapitated happened in the bathroom of the tour bus following the Aug. 31 concert in Spokane, Washington. The band members were arrested Saturday in Santa Ana, California, for investigation of first degree kidnapping. The four men appeared in court in Los Angeles Tuesday and waived extradition to Washington, KABC-TV reported. Steve Graham, a lawyer for the band members, said in an email that the members of "Decapitated plan to fully fight the allegations that have been brought against them and are confident that their side of the story will be heard." Decapitated had been touring with the Australian band Thy Art is Murder, and performed several shows after the Spokane concert before being arrested. Arrested were band members Michal Lysejko, 31; Waclaw Kieltyka, 35; Rafal Piotrowski, 31; and Hubert Wiecek, 30. The woman and her friend told Spokane police they attended the Aug. 31 show, spoke with members of Decapitated and were invited to have drinks in the tour bus. Once on the bus, the women reported they began to feel uncomfortable. One of the women went to use the bathroom on the bus and was followed inside by a band member, according to the documents filed by police in Spokane County Superior Court. The woman tried to push him away, "but he grabbed her arm and spun her around to where she was facing the sink and mirror in the bathroom," court documents said. "She saw in the mirror and out of the corner of her eye each of the band members taking turns raping her," the documents said. The woman's friend told police in the documents that she watched the band members commit the assault. The woman said a band member helped her get dressed and carried her out of the bus before she walked away and called 911. A police officer who picked her up returned to the concert venue, but the tour bus was gone. The documents said the woman was examined at a hospital where she was found to have upper arm bruises consistent with being restrained and other injuries. Graham, the band's attorney, told The Spokesman-Review newspaper, "We have witnesses that can testify to the fact that the accuser came to visit the band of her own free will and left on good terms." Band members were interviewed Thursday by sheriff's detectives. Lysejko told officers he did not know the women when shown a picture of her. Kieltyka said he saw two members of the band engage in sex acts with the woman in the bus bathroom, the court documents said. Piotrowski said the women were at a party on the bus but declined additional comment, while Wiecek said the two women had been on the bus but he did not see what was going on, court documents said. The women were not identified in the court documents.

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ST. PETERSBURG, Russia — Belgium and England both leave the World Cup happy to have reached the semifinals. Belgium may be a little happier, though. The Belgians earned their highest World Cup finish by beating England 2-0 in the third-place match on Saturday. Thomas Meunier and Eden Hazard scored a goal each. "These players didn't want to rely on talent anymore, wanted to work as a team," Belgium coach Roberto Martinez said. "Their standards have been magnificent. They wanted to make the country proud, every single Red Devils fan proud." France and Croatia will play in the final on Sunday at the Luzhniki Stadium in Moscow. The French beat Belgium on Tuesday in the semifinals, while the Croats defeated England on Wednesday. Meunier's early goal matched a World Cup record for Belgium by having 10 different players score in a tournament, something only done before by France in 1982 and Italy in 2006. Both Belgium and England were playing for the seventh time in 26 days, but the Belgians entered the match with an extra day of rest. Meunier scored in the fourth minute, knocking a cross from Nacer Chadli past England goalkeeper Jordan Pickford. Hazard added the other off a pass from Kevin De Bruyne in the 82nd. Toby Alderweireld denied England's best chance of the game, sliding on the goal line to clear a shot from Eric Dier. England matched its best World Cup result — fourth in 1990 — since winning the tournament for the only time in 1966. "Today shows there's room for improvement. We're not the finished article. We're still learning. We're still getting better," England striker Harry Kane said. "We don't want to wait another 20-odd years to get into another major semifinal." Belgium's previous best finish at the World Cup was fourth, but the team outplayed England in the midfield to go one better this time. The Belgians could easily have scored more, with Pickford making a good save to stop a shot from De Bruyne in the 11th and Alderweireld volleying narrowly over the bar in the 35th. England made set pieces the cornerstone of its run to the World Cup semifinals and created chances for Harry Maguire and Dier in the second half. Neither hit the target with their headers. It was the second time England and Belgium met in this year's tournament. In the group stage, both teams had already qualified before Belgium's 1-0 win in Kaliningrad. FRESH LEGS England coach Gareth Southgate made five changes to face Belgium, but Danny Rose and Fabian Delph made little impact while Dier started slowly but threatened in the second half. Phil Jones failed to intercept the pass which led to Hazard's goal. The two replacements in Belgium's lineup were more effective. Meunier scored and Youri Tielemans dominated the midfield. GOLDEN BOOT Kane is still placed to win the Golden Boot with a tournament-leading six goals ahead of Sunday's final. Kane last scored in England's win over Colombia in the round of 16. On Saturday, he slipped as he shot wide in the first half, then failed to make contact with Jesse Lingard's cross early in the second. Romelu Lukaku couldn't add to his four goals for Belgium and was substituted shortly after misjudging a through ball by De Bruyne.

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ST. PETERSBURG, Russia — For Belgium and England, the World Cup’s third-place match was more like a dress rehearsal for future finals. At least they hope. The Belgians earned their best World Cup finish by beating England 2-0 on Saturday in a match both saw as the start of a push for the European Championship title in 2020 or the World Cup in 2022. “With this winning mentality you can win trophies,” said Eden Hazard, who scored Belgium’s second goal. “In two years, in four years, we will be better. We have young players. They are very good also in the team. They push all of us.” Thomas Meunier and Hazard both scored at St. Petersburg Stadium in a match between the two semifinal losers. France and Croatia will play in the final on Sunday at the Luzhniki Stadium in Moscow. The French beat Belgium on Tuesday in the semifinals, while the Croats defeated England on Wednesday. England matched its best World Cup result — fourth in 1990 — since winning the tournament for the only time in 1966. “Today shows there’s room for improvement. We’re not the finished article. We’re still learning. We’re still getting better,” England striker Harry Kane said. “We don’t want to wait another 20-odd years to get into another major semifinal.” Both Belgium and England were playing for the seventh time in 26 days, but the Belgians entered the match with an extra day of rest. Meunier’s goal matched a World Cup record for Belgium by having 10 players score in a tournament, something only done before by France in 1982 and Italy in 2006. Meunier scored in the fourth minute, knocking a cross from Nacer Chadli past goalkeeper Jordan Pickford. Hazard added the other off a pass from Kevin De Bruyne in the 82nd. Toby Alderweireld denied England’s best chance, sliding on the goal line to clear a shot from Eric Dier. Belgium’s previous best finish at the World Cup was fourth, but the team outplayed England in the midfield to go one better this time. The Belgians could easily have scored more, with Pickford making a good save to stop a shot from De Bruyne in the 11th minute and Alderweireld volleying narrowly over the bar in the 35th. England made set pieces the cornerstone of its run to the World Cup semifinals and created chances for Harry Maguire and Dier in the second half. Neither hit the target with headers. It was the second time England and Belgium met in this year’s tournament. In the group stage, both teams had qualified before Belgium’s 1-0 win in Kaliningrad. England coach Gareth Southgate made five changes to face Belgium, but neither Danny Rose nor Fabian Delph made much of an impact. Dier started slowly but threatened in the second half. Phil Jones failed to intercept the pass which led to Hazard’s goal. The replacements for Belgium were more effective. Meunier scored and Youri Tielemans dominated midfield. Golden Boot: Kane is still poised to win the tournament award for high scorer with a tournament-leading six goals ahead of Sunday’s final. Kane last scored in England’s win over Colombia in the round of 16. On Saturday, he slipped as he shot wide in the first half, then failed to make contact with Jesse Lingard’s cross early in the second. Romelu Lukaku couldn’t add to his four goals for Belgium and was substituted shortly after misjudging a through ball by De Bruyne. Among the final match participants, Antoine Griezmann and Kylian Mbappe of France each have three goals. James Ellingworth is an Associated Press writer.

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STC buses are an essential service in Saskatchewan Article content Bob Abernethy of Estevan writes: Advertisement 2 Article content In his Feb. 16 Leader-Post article, Todd MacKay of the Canadian Taxpayers Federation talks of the huge deficits provincial governments are racking up, which I agree is a concern, but he then concludes the Saskatchewan Transportation Company (STC) must be killed off, which I don’t agree with. tap here to see other videos from our team. STC buses are an essential service in Saskatchewan Back to video He believes some customers would be “inconvenienced.” Many Saskatchewan people, for a wide variety of reasons, don’t have good transportation options. For them, not having a bus service — as meagre as it is — would go well beyond being “inconvenienced.” What about those people, Mr. MacKay? I, too, despise deficit financing. Governments are putting charges on credit cards for us, our kids and our grandchildren and we seem to gobble it right up. However, some things are worth subsidizing, and continued bus service within Saskatchewan is one of them. (If Premier Brad Wall wants to reduce the debt a bit he could eliminate the three new MLA positions he created.)

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STOUGHTON, Sask. — The Saskatchewan government says it has confirmed which pipeline leaked 200,000 litres of crude oil on First Nation farmland. It says it belongs to Calgary-based Tundra Energy Marketing Ltd. The company has been leading cleanup of the spill near Stoughton in southeastern Saskatchewan. The government says so far 174,000 litres of oil have been recovered and 185,000 cubic metres of contaminated soil removed. It says further assessment and cleanup, including excavation work, will follow until the site is restored. Tundra confirmed on its website that it is the operator of the pipeline and is working with regulatory bodies and the Ocean Man First Nation to determine the cause. Chief Connie Big Eagle said a band member who worked in the oil industry detected the smell of oil days before the leak was discovered. The member eventually found the site of the spill contained in a small slough and reported it to officials on Friday. She said emotions among the 540 band members range from disappointment to anger. “Many of our people grew up in the oil industry and have made their careers in the oil industry and currently work in the oil industry, so there’s lots of knowledge,” she said in an interview Tuesday. “I don’t know about things returning to normal, as far as the environment goes, but I know we’re all co-operating at this point, ensuring it’s cleaned up properly and no further damage is caused to the land or the environment.” Tundra has said it immediately notified government officials and residents when the leak was reported and began removing surface oil with vacuum trucks. Tundra is a subsidiary of grain and energy conglomerate James Richardson &Sons, Ltd., of Winnipeg. The Ocean Man spill is almost as big as a 225,000-litre leak of heavy crude oil and diluent from a Husky Energy (TSX:HSE) pipeline into the North Saskatchewan River last July. The leak forced the cities of North Battleford, Prince Albert and Melfort to shut off their water intakes from the river and find other water sources for almost two months. Husky said it spent about $90 million responding to the spill, which it said was caused by shifting ground.

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Sac Metro Prepares For Fires With Fire Risk High Due to the recent red flag warning this weekend, fire risk is high. Sac Metro Fire is preparing for the worst. UP NEXT UP NEXT Beloved Gilroy Garlic Festival Canceled Amid Rising Costs, Pandemic UncertaintyCBS Sacramento Accident On Business 80 Sends 1 Person To HospitalCBS Sacramento Chain Controls Remain In Effect Along Sierra RoadwaysCBS Sacramento Friday Weather Forecast - April 22, 2022CBS Sacramento New Details Revealed In Random Stabbing Of Stagg High School StudentCBS Sacramento No Injuries After Shooting At Applebee's On March Lane In StocktonCBS Sacramento Sacramento Homeless Camp Cleared Out By City Task ForceCBS Sacramento Residents Hit With Tornado Scare In Valley SpringsCBS Sacramento Snow In Sierra Helps Local Businesses Impacted By Dry WinterCBS Sacramento Evening Forecast - 4/21/22CBS Sacramento CBS13 Investigates: GoFundMe Scam Aims To Profit Off Stagg High StabbingCBS Sacramento Drivers Pull Over In Nyack To Put Chains On Tires Amid SnowstormCBS Sacramento 2 People With Gunshot Wounds Found Dead In Downtown SacramentoCBS Sacramento Phone Call With Jackson Resident And Tornado Warning ExpiresCBS Sacramento Phone Call With Valley Springs Resident Impacted By Tornado WarningCBS Sacramento Viewer Video From Pardee Lake Captures Clouds Amid Tornado WarningCBS Sacramento

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Sand mining, export stopped at Maui Lani construction project Maui News readers report sand movement over the weekend The Honolulu-based concrete production company that has been moving sand from Central Maui to other places off-site, including Oahu, has stopped transporting sand, following a formal notice from Maui County regarding permit issues on Monday. Honolulu Construction & Draying President Wade Wakayama said in an email Wednesday afternoon that no sand has been hauled out of a Maui Lani project since Monday. HC&D is reviewing the Maui County notice, he said. Last week, Wakayama said HC&D’s grading activity at Maui Lani was in compliance with its current grading permit. But county Department of Planning Director William Spence said last week that grading permits were issued properly, but the excavation and exporting of “high-quality sand for making concrete and other purposes meets the definition of a ‘resource extraction.’ ” Resource extraction may require either a special or conditional use permit, he said. While sand mining is not illegal, some community members are concerned about the resource being depleted and shipped off-island and archaeological damage. Spence said in an email Wednesday that county officials had considered sending a warning letter via regular certified mail, but thought it would take too long. So, the county emailed the warnings Friday and hand-delivered them on Monday to Maui Lani Partners and HC&D. Through a Uniform Information Practices Act request, The Maui News obtained the letter sent to the companies as well as emails between the county and HC&D. The warning email was sent to Wakayama at 4:40 p.m. Friday, after the Planning Department found a correct email address for the company. The letter sent via email and hand-delivered to the companies asks HC&D and Maui Lani to “correct any violations immediately upon receipt of this notice.” The letter from John Rapacz, administrator of the Planning Department’s Zoning Administration and Enforcement Division, also said that resource extraction use is not permitted within the Maui Lani Project District. It added that fines could be assessed if violations occur. Rapacz said in the email late Friday afternoon to HC&D that the notice of warning is dated May 1, but that allowed for U.S. Postal Service delivery. In an email reply to Rapacz on Monday, Wakayama said he was not in the office for several days so he did not receive a letter other than the email. “We’ve stopped any grading work as of today (Monday) until clarification, etc. can be determined,” he wrote. Spence said that he has not heard from Maui Lani Partners. The Maui News was unable to reach Maui Lani Partners officials for comment on Wednesday. “We will monitor for compliance,” Spence said. Wakayama told The Maui News that the company has updated the county on its on-site activities and would continue to work with the county to ensure HC&D’s work is carried out properly and in permit compliance. “Any work on the site since (Monday) are for purposes of erosion and dust control as well as stabilization which are normal and important safety practices,” Wakayama said. The Maui News readers reported over the weekend that they believed they saw sand moving from the Maui Lani site. Spence said: “It’s disturbing to me that hauling may have taken place on Saturday because it sure seems all of the parties were already aware of the issue, but it illustrates our concern to get the warnings into their hands.” The county’s investigation into the sand matter was triggered by a KHON2 news report investigation into grading and sand moving work in Central Maui, county officials said. The report said Maui Lani Partners has a permit to excavate at one of its sites. A map shows the land is adjacent to Maui Lani Parkway and west of The Dunes at Maui Lani Golf Course. The news report said trucks transport the sand to a mound on land leased from Alexander & Baldwin. HC&D, formerly know as Ameron, is the lessee and through another permit moves sand from the site to a barge at Kahului Harbor, where it is shipped to the company’s plant on Oahu. Maui Lani Partners has said all earth-moving activities are overseen by an archaeological monitor in accordance with the state-approved monitoring plan. There have been reports of sign-waving rallies on Maui this week in opposition to sand mining. Last week, Mayor Alan Arakawa sent a letter to the Maui County Council to consider a moratorium on sand mining, as he suggested in 2006. Maui County spokesman Rod Antone said that officials in the mayor’s office, Corporation Counsel, Public Works and Planning departments, along with Council Member Bob Carroll, met Tuesday to see what could be done about sand mining. Antone said Carroll volunteered his staff to come up with new legislation while the Planning Department enforces existing zoning rules and regulations. “Both the mayor and the councilman are very passionate about this issue,” Antone said. Carroll has been trying to stop sand mining since 2001. * Melissa Tanji can be reached at mtanji@mauinews.com.

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Sanofi and Regeneron Announce Positive Dupilumab Topline Results From Phase 3 Trial in Uncontrolled Persistent Asthma
- Investigational dupilumab reduced severe asthma attacks and improved lung function -
Paris, France and Tarrytown, New York - September 11, 2017 -
Sanofi and Regeneron Pharmaceuticals, Inc. today announced that the pivotal Phase 3 LIBERTY ASTHMA QUEST study of dupilumab in a broad population of patients with uncontrolled, persistent asthma met its two primary endpoints.
Dupilumab, when added to standard therapies, reduced severe asthma attacks (exacerbations) and improved lung function. At 52 weeks, in the 300 mg dose group, dupilumab reduced severe asthma attacks by 46 percent in the overall population, 60 percent in patients with 150 eosinophilic cells/microliter or greater, and 67 percent in patients with 300 eosinophilic cells/microliter or greater (p less than 0.001 for all groups). At 12 weeks, in the 300 mg dupilumab dose group, mean improvement in lung function over placebo as assessed by forced expiratory volume over one second (FEV1) with dupilumab was 130 mL (9 percent) in the overall population, 210 mL (11 percent) in patients with 150 eosinophilic cells/microliter or greater, and 240 mL (18 percent) in patients with 300 eosinophilic cells/microliter or greater (p less than 0.001 for all groups).
The companies plan to submit a Supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) by the end of this year.
"Approximately one million U.S. adults and adolescents live with uncontrolled, persistent asthma, and continue to experience serious asthma attacks, despite taking an intensive regimen of standard therapies," said George D. Yancopoulos, M.D., Ph.D., President and Chief Scientific Officer of Regeneron. "Dupilumab has now demonstrated positive late-stage results in two serious allergic diseases -- asthma and atopic dermatitis -- with robust efficacy and an extensive safety database. These results continue to support our hypothesis that the IL4/IL13 pathway is a critical driver of allergic disease, and weremain committed to further investigating the IL-4/IL-13 pathway in other allergic diseases."
The results for the 200 mg and 300 mg dupilumab dose groups were generally comparable on both exacerbations and FEV1. The extent of patient response correlated with allergic or atopic status as reflected by blood eosinophils and other markers. Less activity was observed in patients with less than 150 eosinophilic cells/microliter. The overall rates of adverse events, deaths, infections, conjunctivitis, herpes and discontinuations were comparable between the dupilumab and placebo groups. Injection site reactions were more common in the dupilumab groups occurring in 17 percent of dupilumab patients compared to 8 percent of placebo patients.
"We believe that therapies like dupilumab, which focus on specific molecular pathways such as the Th2 pathway associated with multiple chronic allergic diseases, are important targets for further investigation," said Elias Zerhouni, M.D., President, Global R&D, Sanofi. "The positive data from this large second pivotal trial in uncontrolled persistent asthma, following the positive results of dupilumab in atopic dermatitis, further support this view in our opinion. We will work diligently with health authorities to bring this new application of dupilumab to the patients who most need it."
The QUEST pivotal Phase 3 trial enrolled 1,902 patients including 1,795 adults and 107 adolescents across 413 study sites worldwide. The four study groups included patients treated with 200 mg every other week with a loading dose of 400 mg, 300 mg every other week with a loading dose of 600 mg, and two separate placebo groups. Patients were randomized in a 2:1 fashion to active drug versus placebo. The two primary endpoints of the study were the annualized rate of severe exacerbation events at 52 weeks and the absolute change from baseline in a standard measure of lung function known as pre-bronchodilator forced expiratory volume over one second (FEV1) at 12 weeks (changes of 100 to 200 mL are considered clinically relevant). The pre-specified primary analysis included hierarchical evaluation of these endpoints in the overall population, in patients with 150 eosinophilic cells/microliter or greater, and in patients with 300 eosinophilic cells/microliter or greater. In the study, approximately 50 percent of patients had 300 eosinophilic cells/microliter or greater and approximately 70 percent of patients had 150 eosinophilic cells/microliter or greater. Higher eosinophil counts are generally thought to be associated with poorer asthma control and higher rates of exacerbations, as was observed in the placebo patients in this study.
All patients continued on a medium or high dose inhaled corticosteroid (ICS) and up to two additional controller medicines throughout the study. Eosinophil subgroups were classified based on baseline levels.
Detailed results from this study will be submitted for presentation at a future medical congress. QUEST is the second pivotal trial in uncontrolled persistent asthma following a positive Phase 2b pivotal study of dupilumab. Data from another Phase 3 study known as VENTURE examining the ability of dupilumab to reduce oral corticosteroid use in patients with severe steroid-dependent asthma are expected later this year. Also included in the LIBERTY ASTHMA clinical development program is the TRAVERSE trial, a long-term safety extension study. The potential use of dupilumab in asthma is currently under clinical development and the safety and efficacy have not been fully evaluated by any regulatory authority.
In March 2017, the FDA approved Dupixent® (dupilumab) in the U.S. for the treatment of moderate-to-severe atopic dermatitis that is not adequately controlled with topical prescription therapies.
About Uncontrolled Persistent Asthma
People who live with uncontrolled persistent asthma often have severe attacks (exacerbations) that may lead to emergency room visits, hospitalizations and decreased lung function. Despite currently available treatments, there is a need for new medicines that offer comprehensive asthma control including preservation of lung function and reduction in exacerbations.[i],[ii] Uncontrolled persistent asthma is often associated with other Type 2 allergic inflammatory diseases including atopic dermatitis, nasal polyps, allergic rhinitis, eosinophilic esophagitis and food allergies. The disease is characterized by an imbalance or overactivity of certain immune cells (including eosinophils) and signaling proteins known as interleukins. Two of these are Interleukin-4 (IL-4) and interleukin-13 (IL-13) 1-,[iii],[iv],[v], which are central drivers of Type 2 inflammation.
About Dupilumab Clinical Programs
Dupilumab is a fully human monoclonal antibody that is designed to simultaneously inhibit overactive signaling of IL-4 and IL-13 cytokines, one of the root causes of Type 2 allergic inflammation. Sanofi and Regeneron are studying dupilumab in a broad range of clinical development programs for diseases that are driven by Type 2 inflammation, including pediatric atopic dermatitis (Phase 3) nasal polyps (Phase 3) and eosinophilic esophagitis (Phase 2). These potential uses are investigational and the safety and efficacy have not been evaluated by any regulatory authority. Dupilumab is being jointly developed by Regeneron and Sanofi under a global collaboration agreement.
Dupixent® (dupilumab) is the first and only biologic medicine FDA-approved for the treatment of adults with moderate-to-severe atopic dermatitis (AD) whose disease is not adequately controlled with topical prescription therapies.
For more information on dupilumab clinical trials please visit www.clinicaltrials.gov.
About Sanofi
Sanofi, a global healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients' needs. Sanofi is organized into five global business units: Diabetes and Cardiovascular, General Medicines and Emerging Markets, Sanofi Genzyme, Sanofi Pasteur and Consumer Healthcare. Sanofi is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).
Sanofi Genzyme focuses on developing specialty treatments for debilitating diseases that are often difficult to diagnose and treat, providing hope to patients and their families.
About Regeneron Pharmaceuticals, Inc.
Regeneron (NASDAQ: REGN) is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for nearly 30 years by physician-scientists, our unique ability to consistently translate science into medicine has led to six FDA-approved treatments and over a dozen product candidates, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, heart disease, allergic and inflammatory diseases, pain, cancer, infectious diseases and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through its proprietary VelociSuite® technologies, including VelocImmune® which yields optimized fully-human antibodies, and ambitious initiatives such as the Regeneron Genetics Center, one of the largest genetics sequencing efforts in the world. For additional information about the company, please visit www.regeneron.com or follow @Regeneron on Twitter.
Sanofi Forward-Looking Statements
This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates regarding the marketing and other potential of the product, or regarding potential future revenues from the product. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans" and similar expressions. Although Sanofi's management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, unexpected regulatory actions or delays, or government regulation generally, that could affect the availability or commercial potential of the product, the absence of guarantee that the product will be commercially successful, the uncertainties inherent in research and development, including future clinical data and analysis of existing clinical data relating to the product, including post marketing, unexpected safety, quality or manufacturing issues, competition in general, risks associated with intellectual property and any related litigation and the ultimate outcome of such litigation, and volatile economic conditions, as well as those risks discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in Sanofi's annual report on Form 20-F for the year ended December 31, 2016. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements.
Regeneron Forward-Looking Statements and Use of Digital Media
This news release includes forward-looking statements that involve risks and uncertainties relating to future events and the future performance of Regeneron Pharmaceuticals, Inc. ("Regeneron" or the "Company"), and actual events or results may differ materially from these forward-looking statements. Words such as "anticipate," "expect," "intend," "plan," "believe," "seek," "estimate," variations of such words, and similar expressions are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. These statements concern, and these risks and uncertainties include, among others, the nature, timing, and possible success and therapeutic applications of Regeneron's products, product candidates, and research and clinical programs now underway or planned, including without limitation Dupixent® (dupilumab) Injection; the likelihood, timing, and scope of possible regulatory approval and commercial launch of Regeneron's late-stage product candidates and new indications for marketed products, such as Dupixent for the treatment of uncontrolled, persistent asthma in adults and adolescents and other potential indications; unforeseen safety issues and possible liability resulting from the administration of products and product candidates in patients, including without limitation Dupixent; serious complications or side effects in connection with the use of Regeneron's products and product candidates (such as Dupixent) in clinical trials; coverage and reimbursement determinations by third-party payers, including Medicare, Medicaid, and pharmacy benefit management companies; ongoing regulatory obligations and oversight impacting Regeneron's marketed products, research and clinical programs, and business, including those relating to the enrollment, completion, and meeting of the relevant endpoints of post-approval studies; determinations by regulatory and administrative governmental authorities which may delay or restrict Regeneron's ability to continue to develop or commercialize Regeneron's products and product candidates, such as Dupixent; competing drugs and product candidates that may be superior to Regeneron's products and product candidates; uncertainty of market acceptance and commercial success of Regeneron's products and product candidates and the impact of studies (whether conducted by Regeneron or others and whether mandated or voluntary) on the commercial success of Regeneron's products and product candidates; the ability of Regeneron to manufacture and manage supply chains for multiple products and product candidates; unanticipated expenses; the costs of developing, producing, and selling products; the ability of Regeneron to meet any of its sales or other financial projections or guidance and changes to the assumptions underlying those projections or guidance; the potential for any license or collaboration agreement, including Regeneron's agreements with Sanofi, Bayer, and Teva Pharmaceutical Industries Ltd. (or their respective affiliated companies, as applicable), to be cancelled or terminated without any further product success; and risks associated with intellectual property of other parties and pending or future litigation relating thereto, including without limitation the patent litigation relating to Praluent® (alirocumab) Injection, the permanent injunction granted by the United States District Court for the District of Delaware that, if upheld on appeal, would prohibit Regeneron and Sanofi from marketing, selling, or manufacturing Praluent in the United States, the outcome of any appeals regarding such injunction, the ultimate outcome of such litigation, and the impact any of the foregoing may have on Regeneron's business, prospects, operating results, and financial condition. A more complete description of these and other material risks can be found in Regeneron's filings with the United States Securities and Exchange Commission, including its Form 10-K for the year ended December 31, 2016. Any forward-looking statements are made based on management's current beliefs and judgment, and the reader is cautioned not to rely on any forward-looking statements made by Regeneron. Regeneron does not undertake any obligation to update publicly any forward-looking statement, including without limitation any financial projection or guidance, whether as a result of new information, future events, or otherwise.
Regeneron uses its media and investor relations website and social media outlets to publish important information about the Company, including information that may be deemed material to investors. Financial and other information about Regeneron is routinely posted and is accessible on Regeneron's media and investor relations website (http://newsroom.regeneron.com) and its Twitter feed (http://twitter.com/regeneron).
Contacts Sanofi:
U.S. Communications
Carrie Brown
Tel: +1 (908) 981-6486
Mobile: +1 (908) 247-6006
Carrie.Brown@sanofi.com
Contacts Regeneron:
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[i] Bjermer L. Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation. J Allergy Clin Immunol. 2007;120(6):1269-1275.
[ii] Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2015.
[iii] Fulkerson PC, Rathenberg ME. Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov. 2013;12(2)1-23.
[iv] Caruso M, Crisafulli E, Lizzio R, Polosa R. Biologic therapy for atopic asthma and beyond. Curr Opin Allergy Clin Immunol. 2013;13(6):677-685.
[v] Platts-Mills TAE, Adachi M, Busse WW, Holgate ST. Asthma. In: Holgate ST, Church MK, Broide DH, Martinez FD, eds. Allergy. 4th ed. Edinburgh, UK: Elsevier Saunders; 2012:181-202.
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Saturday, 30 September 2017 To order photos please email office@greystar.co.nz quoting the photo title number(s), for example "WFF001"

O O O O O O O O O B-MISC O O O O O O O O


Scott Pruitt, the former Oklahoma attorney general who sued the US Environmental Protection Agency to block rules against toxic air pollution, is now the head of the agency. Pruitt was confirmed in a Senate vote today, 52-46. His ties to climate-change deniers and the fossil-fuel industry (and the 13 lawsuits he has filed alongside oil and gas companies against the EPA) made him a particularly controversial appointee to lead the agency. “Scott Pruitt represents what we environmental lawyers call an ‘imminent and substantial endangerment’ to our health and environment,” Ellen Spitalnik, a former EPA attorney who served Republican and Democratic administrations from 1980 to 2002, said in a statement. She along with nearly 800 former EPA employees signed a letter opposing Pruitt for administrator. “He threatens the very integrity of EPA and must not be allowed to continue shutting down environmental enforcement, disregarding science, and putting private interests above public good.” In one scandal, Pruitt received a letter drafted by a major oil and gas company, put his letterhead on it, and sent it to the EPA as an official complaint from the Oklahoma attorney general’s office. In a report on the letter, the New York Times called it evidence of an “unprecedented, secretive alliance” between Pruitt and the oil and gas industry. Among his lawsuits against the EPA were efforts to undermine the agency’s Mercury and Air Toxics Standards, which went into effect in 2012. They limit the amount of mercury, cyanide, acid gas, and other toxic chemicals that power plants can legally emit. Pruitt also sued to block the Cross-State Air Pollution Rule, which curbs power plant emissions of sulfur dioxide and nitrogen oxides but has yet to take effect—it is scheduled to be effective in May of this year. To finalize rules like these, the EPA always has to quantify the benefits: In studies of both rules, each were found to prevent the premature deaths of tens of thousands of Americans per year. During Pruitt’s Senate confirmation hearing, John Barrasso, a Republican senator from Wyoming, remarked that Pruitt enjoys the support of the Cornwall Alliance, an Evangelical organization that considers the scientific consensus on climate change a product of “sin,” and environmentalism to be a “native evil.” Cataclysmic climate change can’t exist, the group says, because God’s intelligent design is flawless, and would not allow it to happen. The organization reportedly has financial ties to the US oil billionaire Koch brothers. All this, combined with president Donald Trump’s promises to gut the EPA and early steps taken to prevent EPA employees from talking to the public, has current EPA employees bracing for the worst. With Pruitt now in place as administrator, a budget for the EPA’s next fiscal year will likely be published soon, which will help determine whether the agency will still have the staff and funds necessary to enforce environmental and public health regulations.

B-PER I-PER O O B-ORG O O O O O B-ORG I-ORG I-ORG I-ORG O O O O O O O O O O O O O O B-PER O O O O B-ORG O O O O O O O O O O O O O O O O O O O O O O O O O O B-ORG O O O O O O O O O O B-PER I-PER O O O O O O O O O O O O O O O O B-PER I-PER O O B-ORG O O O O O O O O O O O O O O O O O O O O O B-ORG O O O O O B-PER O O O O O O O O B-ORG O O O O O O O O O O O O O O O O O O O O O O O B-PER O O O O O O O O O O O O O O O O O O O O O B-ORG O O O O O O B-ORG O O O O O O O O O O B-ORG I-ORG I-ORG O O O O O O O O O B-PER O O O O O O O O O O O B-ORG O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-PER O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-ORG O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-PER B-ORG O O B-PER I-PER O O O O B-LOC O O B-PER I-PER O O O O B-ORG I-ORG O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-ORG O O B-PER O O O O O B-PER I-PER I-PER O O O O B-ORG O O O O O O B-ORG O O O O O O O O B-ORG O O O O O O B-PER O O O O O O O O O B-ORG O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


Search Results 1 Alisal Guest Ranch 150 Alisal Rd, Solvang, CA 93463 805-688-5098 2 Alisal Guest Ranch & Resort 1054 Alisal Rd, Solvang, CA 93463 805-688-6411 3 Tejon Ranch Co. 5545 Laval Rd, Arvin, CA 93203 661-858-1105 More ➡ Print Ads Classified Flyerboard Ad Classified Flyerboard Ad Classified Flyerboard Ad Classified Flyerboard Ad Classified Flyerboard Ad Bulletin

O O O B-ORG I-ORG I-ORG B-MISC I-MISC I-MISC I-MISC I-MISC I-MISC B-MISC O B-ORG I-ORG I-ORG I-ORG I-ORG B-MISC I-MISC I-MISC I-MISC I-MISC I-MISC B-MISC O B-ORG I-ORG I-ORG B-MISC I-MISC I-MISC I-MISC I-MISC I-MISC B-MISC O O O O O O O O O O O O O O O O O O O O


Search and rescue crews are looking for a hiker missing since Wednesday. Sung Yi's son tells 11 News his father went hiking near Ophir Creek Road in the Sangre de Cristo Mountains Wednesday and split off from his group. His companions waited for him at a meeting spot, but he never showed up. Custer County Search and Rescue was dispatched at 5 a.m. Thursday according to the son. The area where Yi, 60, was last seen is near Highway 165 west of Beulah Valley.

O O O O O O O O O O O O B-PER I-PER I-PER O O O O O O O O B-LOC I-LOC I-LOC O O B-LOC I-LOC I-LOC I-LOC O O O O O O O O O O O O O O O O O O O O O B-ORG I-ORG I-ORG I-ORG I-ORG O O O O O O O O O O O O O B-PER B-MISC O O O O O B-LOC I-LOC I-LOC I-LOC I-LOC I-LOC


Search results on ‘Metso’ Heavy lifting ... grinding rolls and has had discussions with Metso over... Noel Dyson 08 Sep 2017 16:45 Metso hauls new deal ...Under the contract, Metso will design, supply..., with the second installed in early 2006, Metso... ben.oliver@aspermont.com 20 Dec 2004 00:00 Grinding data for insight ...Metso vice-president grinding King Lim, told... plant, including the thousands of Metso crushers... what do with it.”He also warned that while Metso... richard.roberts@mining-journal.com 29 May 2017 10:49 Eye on energy for cost-cutting ..., Orica, New Gold Inc, Derrick Corporation, Metso, AMIRA... haydn.black@aspermont.com 21 Jul 2015 00:00 The sound of cheque books opening ..., but is cautious on Metso – strong in iron ore – and... means a bit of a negative for Sandvik and Metso, major... Staff Repoter 19 Feb 2015 00:00

O O O B-ORG O O O O O O O O O O B-ORG O B-PER I-PER O O O O B-ORG O O O O O O B-ORG O O O O O O O O O O B-ORG O O O O O O O O O B-ORG O O B-PER I-PER O O O O O O B-ORG O O O O O O O O O B-ORG O O O O O O O O O O O B-ORG B-ORG I-ORG I-ORG B-ORG I-ORG B-ORG B-ORG O O O O O O O O O O O O O O O O B-ORG O O O O O O O O O O O O O O B-ORG O B-ORG O O O O O O O


O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

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