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] | Established hospital surveillance systems that are in place for influenza and other diseases in Europe may be expanded for this purpose. In addition, a number of countries in Europe are adapting and, in some cases, already using existing sentinel primary care based surveillance systems for influenza to detect community transmission of SARS-CoV-2 | 14,099 | 14,446 | [
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] | All influenza A pandemics since that time, and
indeed almost all cases of influenza A worldwide (except-
ing human infections from avian Viruses such as H5N1 and
H7N7), have been caused by descendants of the 1918
Virus, including “drifted” H1N1 Viruses and reassorted
H2N2 and H3N2 Viruses. | 1,439 | 1,727 | [
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] | baculovirus-derived recombinant HA vaccine was approved for human use and was first available for use in the United States for the 2013-2014 influenza season | 19,506 | 19,663 | [
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] | The incidence in high-income countries is estimated at 0.015 episodes per child year, compared to 0.22 episodes per child year in low-and middle-income countries [3] . On average, 1 in 66 children in high-income countries is affected by pneumonia per year, compared to 1 in 5 children in low-and middle-income countries. | 3,310 | 3,630 | [
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33444,
48497,
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7552,
11430,
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63520,
13313,
7487,
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39169,
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23825,
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2132,
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36165,
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10160,
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31,
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4232,
9283,
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10121,
4418,
13558,
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6226,
1985,
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1935,
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32760,
38546,
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1410,
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10042,
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35410
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1,
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] |
[
1562,
304,
248,
14830,
2804,
275,
6362,
7590,
6703,
427,
2079,
38107,
39892,
1842,
204,
3690,
204,
19,
51,
3565,
65,
24,
3690,
15132,
28023,
6663,
6362,
13241,
13930,
18069,
13248,
5229,
431,
38107,
39892,
1842,
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3690,
272,
9407,
29331,
4884,
284,
6582,
272,
204,
626,
30,
37,
241,
16702,
49483,
2220,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
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81,
1704,
54940,
31,
77,
45876,
1395,
81,
193,
193,
43382,
37,
432,
2412,
331,
7920,
639,
23,
6165,
341,
14292,
2431,
1432,
12651,
925,
23,
61135,
193,
7499,
37,
204,
626,
33,
24,
3627,
24,
660,
193,
40144,
37,
204,
696,
25,
34314,
27,
26,
97,
26100,
21977,
29,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
390,
1175,
275,
3358,
6524,
37337,
17436,
304,
12793,
9570,
25,
7791,
783,
7836,
362,
1742,
3490,
272,
241,
3783,
963,
345,
29246,
304,
248,
3978,
2101,
23,
2035,
2490,
271,
3173,
25,
529,
414,
1856,
241,
11055,
275,
455,
17436,
1217,
272,
29246,
304,
5653,
23,
1774,
335,
248,
1539,
2882,
544,
525,
4445,
271,
3783,
25,
193,
193,
5854,
37,
390,
37337,
18732,
304,
241,
11053,
1380,
312,
11576,
345,
629,
304,
7377,
2072,
335,
248,
2835,
23,
7992,
2666,
248,
10720,
7128,
25,
60019,
326,
275,
248,
9792,
273,
248,
59119,
204,
19,
82,
45567,
9242,
8394,
20,
418,
2887,
28960,
23,
30871,
273,
29246,
25,
49747,
9242,
8394,
304,
4762,
312,
847,
271,
1373,
2261,
10573,
1148,
649,
23,
1591,
334,
532,
275,
248,
758,
2260,
6255,
275,
14830,
204,
70,
28,
72,
204,
25,
6489,
309,
1770,
272,
5463,
3354,
23,
480,
614,
9407,
90,
24,
6734,
397,
1649,
3538,
272,
4027,
3354,
23,
9883,
427,
29246,
25,
3249,
23857,
273,
20221,
27666,
37337,
11576,
362,
28531,
345,
241,
1226,
275,
1583,
19425,
275,
43292,
273,
2899,
8773,
1391,
23,
13149,
27717,
9242,
8394,
304,
416,
28531,
272,
5463,
3354,
204,
70,
29,
72,
204,
25,
529,
248,
4027,
1079,
23,
17436,
362,
1775,
248,
758,
2260,
35688,
8559,
29246,
204,
70,
30,
72,
204,
25,
193,
193,
8127,
17436,
6063,
263,
7305,
618,
1775,
650,
5383,
1428,
204,
7001,
28,
204,
70,
31,
72,
273,
17436,
646,
16065,
271,
884,
241,
2836,
272,
29246,
23,
334,
21982,
1725,
204,
3344,
29,
23,
635,
248,
772,
6429,
8559,
27717,
9242,
8394,
204,
19,
15588,
39892,
20,
398,
6935,
272,
267,
16302,
275,
29246,
272,
7148,
12080,
204,
19,
27418,
23,
2522,
2941,
20,
204,
70,
32,
72,
204,
25,
46139,
852,
248,
12070,
275,
6044,
39892,
1988,
599,
17436,
8559,
27717,
9242,
8394,
646,
6524,
37,
6004,
59225,
272,
47188,
4494,
275,
1770,
335,
27717,
9242,
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204,
70,
33,
72,
204,
23,
6808,
16157,
3598,
272,
15301,
558,
29246,
2913,
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70,
34,
72,
204,
23,
3464,
276,
38107,
620,
36456,
272,
248,
62764,
275,
1770,
335,
13241,
29246,
204,
70,
35,
72,
204,
23,
273,
28123,
39892,
1365,
267,
16302,
275,
27717,
9242,
8394,
272,
267,
37065,
484,
272,
36553,
8878
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1,
1,
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] | two to three million | 919 | 939 | [
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] |
[
5540,
629,
607,
14810,
1542,
271,
1760,
1542,
13930,
13149,
11576,
42,
44,
204,
30,
24,
3113,
16702,
2220,
275,
248,
59027,
275,
13241,
13930,
13149,
11576,
272,
34478,
1770,
272,
62028,
23,
3603,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
41994,
7159,
31,
26,
193,
193,
40853,
37,
24999,
32,
4531,
51748,
33,
705,
35,
77,
1622,
2687,
79,
58619,
13418,
46977,
34,
1622,
27,
4239,
30,
269,
24564,
18637,
193,
193,
43382,
37,
707,
23,
55934,
38,
8329,
23,
39718,
24,
68,
96,
38,
19981,
23,
1199,
280,
82,
38,
319,
1418,
23,
55560,
24,
68,
263,
38,
27348,
23,
48722,
24,
51,
2601,
38,
8329,
23,
43078,
642,
24,
67,
263,
38,
7906,
23,
26406,
24,
47,
515,
38,
7906,
23,
1876,
505,
24,
47,
515,
193,
7499,
37,
204,
626,
31,
24,
3460,
24,
1279,
193,
40144,
37,
204,
696,
25,
11282,
28,
26,
330,
97,
25,
16036,
5831,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
41569,
51834,
37,
390,
59027,
275,
1783,
13149,
886,
84,
4663,
304,
3978,
312,
248,
2579,
275,
13149,
13930,
18732,
11576,
25,
11495,
1211,
362,
1433,
272,
3603,
271,
7474,
248,
59027,
275,
13149,
13930,
11576,
23,
2463,
272,
1385,
600,
42300,
6410,
273,
10088,
2698,
25,
28295,
23559,
54741,
37,
1472,
5017,
248,
13149,
886,
10475,
273,
2120,
1276,
275,
13241,
13930,
11576,
272,
34478,
1770,
23,
241,
204,
30,
24,
3113,
2220,
398,
7819,
272,
62028,
23,
3603,
25,
63968,
62,
37,
22321,
2779,
54094,
12358,
750,
427,
9057,
1770,
646,
8351,
25,
24290,
9133,
273,
599,
13930,
17436,
646,
7636,
431,
16719,
44871,
13932,
25,
4745,
646,
17352,
271,
7474,
248,
9957,
273,
2120,
1276,
25,
18490,
46403,
37,
2960,
248,
204,
905,
32,
1770,
19732,
272,
248,
2220,
23,
204,
51050,
204,
19,
3654,
4100,
27,
7278,
646,
3508,
312,
388,
1931,
532,
13149,
47147,
23,
272,
585,
204,
41347,
204,
19,
10020,
4100,
34,
7278,
646,
204,
39,
31,
909,
275,
2521,
25,
390,
1373,
758,
24301,
17436,
646,
23076,
317,
204,
19,
5172,
65,
38,
204,
2552,
4100,
35,
17925,
13930,
8376,
2586,
95,
470,
6429,
204,
19,
7679,
65,
38,
204,
1067,
4100,
32,
7278,
273,
2079,
29932,
39892,
204,
19,
15466,
65,
38,
204,
1868,
4100,
32,
21423,
2004,
24,
16674,
482,
646,
1217,
272,
204,
24530,
2913,
204,
19,
2791,
4100,
28,
17925,
273,
11779,
13149,
7228,
398,
16435,
25,
18416,
65,
23,
11399,
65,
273,
295,
18796,
646,
248,
758,
11094,
13149,
7836,
3490,
272,
739,
24,
60858,
25,
1440,
248,
2198,
23,
248,
4377,
16767,
26688,
7992,
427,
3102,
271,
1896,
646,
7790,
335,
10648,
4472,
17519,
427,
204,
28,
649,
271,
1382,
25,
9449,
38610,
22825,
37,
735,
2220,
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] | the study was stopped after interim analysis suggested the vaccine did not achieve efficacy and individuals with high preexisting Ad5 antibody titers might have an increased risk of acquiring HIV-1 | 10,868 | 11,065 | [
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3783,
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51834,
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1988,
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691,
10299,
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33262,
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1958,
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5632,
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31003,
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62855,
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808,
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703,
306,
263,
38,
36721,
23,
36396,
38,
7906,
90,
23,
25801,
19864,
38,
23144,
23,
2172,
257,
46984,
38,
61227,
23,
60908,
193,
7499,
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384,
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10160,
2324,
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20,
6078,
304,
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4865,
675,
6078,
335,
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24,
23057,
5353,
272,
23648,
7972,
62986,
273,
21629,
25,
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23,
701,
13313,
275,
2696,
273,
2895,
15824,
8669,
272,
599,
3783,
362,
1102,
19260,
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2220,
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41029,
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248,
12737,
696,
1408,
4354,
271,
325,
272,
248,
49614,
24,
7927,
1873,
1408
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1,
1,
1,
1,
1,
1,
1,
1
] | transforming prothrombin directly into thrombin, | 3,792 | 3,840 | [
0,
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] |
[
1562,
304,
1156,
349,
2266,
63545,
27469,
42,
46,
25,
27469,
204,
29230,
54523,
834,
42237,
27,
44,
2636,
20001,
1489,
252,
2009,
23,
480,
6814,
2203,
2019,
3993,
271,
301,
41050,
16152,
23,
431,
3541,
3132,
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24962,
8896,
47724,
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13999,
9917,
193,
193,
12659,
7561,
17794,
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6825,
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24084,
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16162,
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4111,
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34067,
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46,
40449,
42528,
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193,
193,
40853,
37,
261,
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33268,
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77,
6001,
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24132,
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50108,
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20424,
27681,
9890,
51433,
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7427,
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6001,
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193,
193,
43382,
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16318,
327,
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52228,
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3956,
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626,
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28,
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35048,
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45707,
25,
21977,
34636,
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34729,
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32067,
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12053,
37,
1156,
434,
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1509,
27469,
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26426,
3508,
23,
29382,
58644,
8833,
1509,
325,
418,
1052,
3766,
15411,
991,
1974,
2092,
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390,
8833,
1509,
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20713,
998,
6553,
275,
319,
25,
27469,
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19,
7445,
52,
770,
312,
585,
248,
5699,
418,
2393,
427,
241,
9959,
29246,
271,
8538,
16308,
34785,
279,
357,
1162,
257,
498,
828,
8394,
273,
13975,
24607,
310,
49277,
25,
5973,
1974,
376,
9962,
272,
18597,
276,
1768,
23,
1497,
319,
25,
27469,
23,
304,
26866,
431,
248,
1999,
30985,
312,
34167,
2009,
23,
42237,
27,
44,
25,
529,
33683,
39198,
8161,
32946,
23,
414,
27172,
5864,
304,
614,
3644,
379,
30231,
3490,
272,
2458,
599,
16236,
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23,
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1416,
325,
319,
25,
27469,
42237,
27,
44,
3021,
241,
986,
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275,
33062,
271,
248,
779,
17839,
341,
25,
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32946,
6078,
273,
23785,
241,
2661,
12695,
10277,
25,
703,
931,
325,
248,
13584,
12543,
319,
25,
27469,
204,
29230,
54523,
834,
5153,
267,
204,
1121,
40982,
24,
548,
463,
2351,
2578,
248,
9917,
24,
32266,
7281,
4354,
271,
701,
46412,
12543,
204,
29230,
25,
529,
27468,
12695,
44871,
1241,
38968,
319,
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46402,
9917,
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7281,
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27469,
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44,
6078,
11021,
1430,
12695,
271,
9917,
33207,
275,
11329,
27,
44,
273,
7626,
51,
23,
2304,
34167,
2009,
14617,
273,
1988,
599,
1340,
998,
10796,
25,
529,
27468,
12695,
44871,
2352,
325,
248,
10591,
27240,
248,
2084,
514,
434,
5951,
470,
51662,
301,
9890,
45,
724,
314,
241,
1430,
2865,
275,
42237,
27,
44,
23,
480,
2014,
30666,
384,
13604,
427,
241,
11329,
27,
44,
5300,
12543,
398,
658,
1499,
13975,
3548,
553,
3034,
4494,
661,
325,
7502,
427,
241,
4503,
1842,
12543,
23,
272,
7049,
271,
2732,
4636,
25,
2050,
2196,
5557,
312,
248,
772,
601,
1430,
204,
19,
1567,
998,
20,
10796,
275,
248,
42237,
27,
44,
6078,
272,
319,
25,
27469,
273,
717,
241,
3508,
1334,
275,
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27,
44,
313,
3146,
275,
248,
1902,
514,
434,
5951,
470,
27269,
12271,
25,
193,
193,
5854
] | [
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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