{"text": "Doctor insights on:\nMedicine For Bergers Disease\nClinical Trials: Although available, experimental drugs are given in clinical trials, usually in academic or private institutions with doctors involved in research, where patients that have failed to existing treatment are treat. There are a variety of immunotherapy medications like Remicade (infliximab) that are available for Crohn's you could discuss with your doctor about. Ustekinumab is a clinical trial drug for Crohn's ...Read more\nSome injections: Non-surgical treatments for peyronie's include: waiting (as some penises improve without treatment), or injections of medications such as verapamil or interferon (medications that can decrease the collagen fibrous material in the plaque). An experienced urologist can evaluate to be sure peyronie's is cause of the curvature, and then he may recommend non-surgical treatments as a first step. ...Read more\nWilson's disease: Check out http://www.Mayoclinic.Com/health/wilsons-disease/ds00411 for info re wilson's disease which is autosomal recessive cause of excess copper. Both Penicillamine & trientine are used to chelate & remove excess copper. There's no best drug for everyone but rather a best drug for you. Talk to your doc about what's available to you, what's affordable, and what side effects are tolerable to you. ...Read more\nTesting: Unfortunately, without knowing what part of your testing was abnormal, it is not possible to suggest a treatment. Please give some more specifics, or go see a doctor to review your test results. ...Read more\nCan you tell me an example of a time when medicine was shipped elsewhere to another country in order to stop an epidemic or disease?\nYes: The Canadian Health Minister indicated that Canada will donate between 800 to 1,000 of their 1,500 doses of an experimental Ebola Vaccine - VSV-EBOV to help with the Ebola-Zaire outbreak in West Africa. ...Read more\nHow does nuclear medicine cure diseases? Can anyone give an example of how nuclear medicine is used to cure diseases? I don't understand how it works.\nThe : The best example of how nuclear medicine is used to cure diseases is treatment of thyroid cancer or graves' disease (a form of hyperthyroidism). In both cases the goal is to destroy thyroid tissue. The thyroid gland contains a large amount of iodine which it uses to produce thyroid hormone. Once iodine is ingested, a large amount is concentrated within the thyroid gland. Nuclear medicine harnesses this principal to destroy thyroid tissue by giving the patient a radioactive form of iodine (i-131). This radioactive iodine is concentrated in the thyroid gland. The isotope primarily releases beta radiation which destroys the surrounding tissue (most of which is thyroid tissue). If there is thyroid cancer in the area, the cancer is also destroyed. ...Read moreSee 3 more doctor answers\nHello, I'm 25 years,helthier, no diseases,181cm high,56kg weight,male, I'm too thin,I want a possible drug to increase my weight,my apetite is little.\nDrugs to gain weight: are dangerous if no medical condition indicates their use. Better to eat higher protein such as eggs, dairy, etc. Exercise will tone up your body and help muscle mass. I'm glad your health is good. Enjoy that and focus on being a good person to others, neat and clean. Peace and good health. A smile goes a long way also. ...Read more\nWhich diseases are treated with nuclear medicine? I've read online about the diagnostic properties of nuclear medicine, but there is little information about the diseases which can be treated with nucleur medicine. Which diseases are treated with nuclear\nMostly thyroid.: Thyroid overactivity (hyperthyroidism which may be due to graves disease) and thyroid cancer can be treated with radioactive iodine administered orally. Nuclear medicine can also be used to treat the bone pain due metastases (cancer which has spread to the bone.). ...Read moreSee 2 more doctor answers\nA variety: Of non steroidal anti inflammatory medication as long as there are no contraindications like allergies, use of blood thinners, kidney or liver disease or ulcer/reflux issues . Tylenol (acetaminophen) is an option. Other types of drugs like cymbalta, Elavil and neurontin/lyrica may also help. Ideally, not smoking, regular exercise and weight control are also helpful. Good levels of vitamin d also are important. ...Read more\nNo!!!!!: Many people live with celiac disease and are highly functioning professionals. Strict adherence to a gluten-free diet is crucial. That also means reading labels very carefully. You should shop at the gluten-free section, available in most groceries, be under competent medical supervision. Also see www.celiac.nih.gov/materials.aspx; www.celiac.org/ ...Read moreSee 2 more doctor answers\nAntibiotics: Antibiotics depending on the disease.Get a more detailed answer ›", "label": "Yes"}
{"text": "Invasive species often evolve rapidly in response to novel introduced environments, making them excellent models for the study of evolution.\nInvasive species often evolve rapidly in response to novel introduced environments, making them excellent models for the study of evolution. However, there remains an unsolved paradox: how can introduced populations that typically have low genetic diversity respond so quickly to selection? Is this response primarily based on novel mutations or are there other mechanisms (e.g. epigenetic modifications) through which rapid evolution is occurring in these systems? In this seminar, I will describe my research on rapid evolution in Australian invasive species and discuss future directions that aim to improve our knowledge of the fundamental mechanisms driving evolution during invasion. I will describe data from a range-edge population of invasive starlings (Sturnus vulgaris) in which we have found evidence of rapid evolution of mitochondrial DNA that is linked to changes in mtDNA copy number. I will also discuss changes in gene expression identified in invasive cane toads (Rhinella marina) from original sites of introduction in Australia as compared to range-edge populations. We now are investigating to what degree these changes in gene expression are related to genetic polymorphism, whether they are driven by changes in DNA methylation and the heritability of methylation in this system. Ultimately, I aim to address the possibility that rapid evolution during invasion may be initially driven by environmentally induced epigenetic mechanisms.\nDr Lee Ann Rollins is a UNSW Scientia Fellow in the Evolution & Ecology Research Centre. Dr Rollins' research uses genetic and epigenetic data to examine population and evolutionary processes. Specifically, she employs molecular techniques to investigate mechanisms underlying rapid evolution often seen in invasive populations, using iconic Australian invaders such as the cane toad and starling as models. She is also interested in using genetic data to improve the management of invasive and conserved species.", "label": "Yes"}
{"text": "Heterotrophic plate count (HPC) bacteria are naturally present in all aqueous environments.\nThese bacteria undergo multiplication cycles in drinking water, especially in closed containers (bottled water) or in tap water when chlorine levels are dissipated, such as in dead ends in water mains or household plumbing.\nA study was undertaken to estimate health risk from these naturally occurring bacteria by the determination of cytotoxicity and invasiveness in a human enterocyte cell line.\nHPC bacteria were isolated from bottled and tap water samples by enumerating them under physical and chemical conditions analogous to human physiology.\nAll HPC bacteria were examined at both log and lag phase of their growth cycles.\nBacterial broth supernatant fluids were also tested to serve as critical negative controls.\nNaturally occurring HPC bacteria demonstrated low invasiveness and cytotoxicity with more than 95% of isolates showing equivalency to broth supernatant fluid.\nWhen showing either invasiveness or cytotoxicity, only a small number of cells from the culture were positive.\nOf those that were positive, log phase HPC bacteria were significantly more cytotoxic and invasive than those from stationary phase.\nBacterial broth controls demonstrated varied, but often marked, cytotoxicity.\nMots-clés Pascal : Bactérie, Eau potable, Analyse risque, Virulence, Cytotoxicité, Pathogène, Homme, Côlon, Lignée cellulaire, Lignée CACO2\nMots-clés Pascal anglais : Bacteria, Drinking water, Risk analysis, Virulence, Cytotoxicity, Pathogenic, Human, Colon, Cell line\nNotice produite par :\nInist-CNRS - Institut de l'Information Scientifique et Technique\nCote : 97-0297613\nCode Inist : 002A05B10. Création : 15/07/1997.", "label": "Yes"}
{"text": "Try eating canned salmon to excess fat. Some people do not feel comfortable cooking fresh, raw seafood. If you are one of the people people, consider buying your fish in cans. Alternatively, you could find fish sold in tins, the freezer section, or even individually sealed packages. Many of these fish products require little to no cooking.\nAnother thing that certainly give appreciation of is insulin resistance. That is also because starvation all forms. When you introduce carbohydrates into the diet, hyperinsulinemia and blood glucose level swings may likely occur. This particular really is as a consequence of the advance in the degrees of enzymes in the body system. The enzymes that are chiefly affected are the individuals that are involved with carbohydrates or fats burning. When the human body had not been fed with carbs, stopping a ketosis diet will also imply how the ‘down regulation’ will be changed. Staying on the cyclical ketogenic diet will keep insulin needs in stability. Carbs have always created difficulties if you are with troubles.\nOne reason the low-carb or no-carb (also called ketogenic) diets are so attractive could be because of the large initial weight reduction. However, http://ketocontrol.org/ this weight is certainly not fat. When carbohydrates are restricted h2o has a backup store of them located from the liver and muscles in something called glycogen. The body can store approximately 400 grams of glycogen. In larger individuals this number can enhancement. In addition to this, for every gram of glycogen stored in the human body, 3 grams of water are also stored. If you figure it out, this would equate to around 1600 grams (3.5 pounds) of glycogen and stream.\nSecondly, to burn the fat easily you need to build a correct personal ketosis diet plan menu for women. Knowing your metabolic type will allow you to research and exploit resources moves through your personal fat loss diet. Some sort of daily ketosis diet plan menu for womenning guide will allow you to determine just what kinds of foods it is advisable to be snacking. The easy weight loss meal guide will aid you determine ideal proportions and meal dimensions.\nThe faster food is converted into blood sugar, the faster your with the aid of rise. When blood sugar levels are high, method secretes insulin, its primary storage junk food diet. When insulin is present in the bloodstream, energy nutrients such as fat or carbohydrates are far able to be stored rather than burned. When you’re thinking of fat loss, this means fat is not readily mobilized from fat cells and fat burning slows or stops.\nCan you utilize machines from a gym or at your house? The machine based cardio programs are sometimes a better option if you could have injuries mindful about will be less body impact stress on your metabolism. And it really doesn’t matter what piece. My only advice is in case you are going cord less mouse with machines planet gym, alternate between the various types. Maybe the step mill one day, rower the next, seated recumbent bike position, maybe a spin class, or http://ketocontrol.org/ jogging on the treadmill. Snappy to break it up so that you don’t do precisely type generally and give your body different movement patterns to adjust to while preventing repetitive demand.\nThe cyclical Keto Control Diet guidelines restricts carbohydrates. By restricting carbohydrates, but, maintaining caloric consumption, your body will just have one use of fuel expenditure. That is fat; which is what ketosis are. You are essentially turning on your fat burning machine. Ketones are sent out of your body and fat reduction becomes outstanding. How does this happen? The largest internal organ in your body is the key player. Your liver. The liver features the job of converting fat into ketones. These ketones are then excreted out from the body, weight/fat loss. It is a natural concept.\nKetones also appear to use a diuretic effect, which will mean a good greater lowering of normal .Moreover to normal water, if you have been working out recently to hurry along your “weight loss” (you indicate body fat decline, correct?) progress you most likely have gained some muscle doing thereby. This acquire in muscle additionally be impact the numbers you see on the scale. Muscle is also far more dense than fat.You might be wondering a person can might be going to measure your progress now how the scale doesn’t indicate as very much as it helpful to. Well, the numbers of numerous techniques to measure your bodyfat commission.", "label": "Yes"}
{"text": "+44 1803 865913\nBy: Michel Peissel\n253 pages, B/w photos\nDescribes how in 1994, the author made history twice over - by discovering the source of one of the world's mightiest rivers, the Mekong, high in the ice-strewn fields of the Tibetan Plateau; and by finding a living fossil, the Riwoche horse, a previously unknown species which may prove to be a missing link in equine evolution.\nThere are currently no reviews for this product. Be the first to review this product!\nYour orders support book donation projects\nI don't know how you got a book printed 26 years ago in the conditions that I received it (like new) but you do it! ABSOLUTELY AWESOME!\nSearch and browse over 110,000 wildlife and science products\nMulti-currency. Secure worldwide shipping\nWildlife, science and conservation since 1985", "label": "Yes"}
{"text": "DPP2 Rat anti-Human, Clone: 398011, Invitrogen\nRat Monoclonal Antibody\nManufacturer: Invitrogen MA524133\nReconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.\n|PBS with 5% trehalose and No Preservative|\n|DPP7, Carboxytripeptidase, Dipeptidyl aminopeptidase II, Dipeptidyl peptidase 2, DPPII, Dipeptidyl arylamidase II, Dipeptidyl-peptidase 7, Dipeptidyl-peptidase II, Dipeptidylpeptidase 7, Dipeptidyl peptidase 7, Dipeptidyl peptidase II, DPP II, DPP2, QPP|\n|-20° C, Avoid Freeze/Thaw Cycles|\n|Mouse myeloma cell line NS0-derived recombit human DPPII/QPP/DPP7 Gly22-Leu492|\nWe continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.\nYour feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok", "label": "Yes"}
{"text": "Excellent mini or gherkin cuke which can be picked either at the midget size or small pickle stage and processed. 24\" semi-vining compact plants set masses of scrumptious sweet, crisp little black-spined cukes! 10-12\"H vigorous plants produce about 20-25 fruits. Best picked 2-4\" long. They are delectable raw, sliced, processed and adds a dash of pizazz to any dish! Can be grown in the garden as well as in containers.\nCreated from a controlled method of pollination in which the pollen of two different species or varieties is crossed by human intervention. Typical F1 varieties are deliberately created to breed a desired trait. Gardeners who use hybrid plant varieties usually purchase new seed every year, however, over several years the seed could eventually be used for open pollination\nCucumbers will grow both female and male flowers. Such cucumber plants do not need another cultivar cucumber plant for pollination. They require bees, other insects or wind, however, to spread their pollen from their male flowers to their female flowers.\n* This is an estimated guide. Conditions may vary considerably due to location.", "label": "Yes"}
{"text": "- Research article\n- Open Access\nHydrogen peroxide-producing pyruvate oxidase from Lactobacillus delbrueckii is catalytically activated by phosphotidylethanolamine\nBMC Microbiology volume 20, Article number: 128 (2020)\nPyruvate oxidase (Pox) is an important enzyme in bacterial metabolism for increasing ATP production and providing a fitness advantage via hydrogen peroxide production. However, few Pox enzymes have been characterized from bacterial species. The tetrameric non-hydrogen-peroxide producing Pox from E. coli is activated by phospholipids, which is important for its function in vivo.\nWe characterized the hydrogenperoxide-producing Pox from L. delbrueckii strain STYM1 and showed it is specifically activated by phosphotidylethanolamine (16:0–18:1), but not by phosphotidylcholine or phosphotidylglycerol. This activation is a mixture of K- and V-type activation as both km and enzyme turnover are altered. Furthermore, we demonstrated that the L. delbrueckii Pox forms pentamers and either decamers or dimers of pentamers in solution, which is different from other characterized Pox enzymes. Lastly, we generated a C-terminal truncation mutant that was only weakly activated by phosphotidylethanolamine, which suggests the C-terminus is important for lipid activation.\nTo our knowledge this is the first known hydrogenperoxide-producing Pox enzyme that is activated by phospholipids. Our results suggest that there are substantial differences between Pox enzymes from different bacterial species, which could be important for their role in biological systems as well as in the development of Pox-based biosensors.\nPyruvate oxidase (Pox) is an enzyme in the oxidoreductase family. There are hydrogen peroxide-producing and acetate-producing Pox enzymes. In hydrogenperoxide-producing Pox enzymes, pyruvate, phosphate, and oxygen are converted to acetylphosphate, carbon dioxide, and hydrogen peroxide with the cofactors flavin adenine dinucleotide (FAD) and thiamine pyrophosphate (TPP) . Acetate-producing Pox enzymes catalyze the oxidative decarboxylation of pyruvate to form carbon dioxide and acetate with electrons being transferred directly to the electron transport chain via the membrane-embedded electron carriers [2, 3].\nThe most well studied acetate-producing Pox is from Escherichia coli. E. coli Pox is dependent on the same cofactors as other Pox enzymes and is also homo-tetrameric . E. coli Pox produces acetate and does not utilize oxygen as its final electron acceptor, but rather the membrane embedded ubiquinone 8 electron transport molecule . CidC is another acetate-producing Pox enzyme from Staphylococcus aureus which transfers electrons to menaquinone and has an important role in cell death pathways . Pyruvate:Quinone Oxidoreductase (PQO) from Corynebacterium glutamicum also produces acetate and transfers electrons to a quinone . One characteristic of E. coli Pox, PQO, and CidC is that they are catalytically activated by phospholipids, which is thought to facilitate efficient transfer to membrane electron shuttles by activating the enzyme at a membrane peripheral position [3, 5, 6]. Mutants in E. coli Pox that disrupt lipid activation of the enzyme are localized to the C-terminal region of the protein. Further biochemical analysis identified a lipid activation helix in the C-terminal region (amino acids 558–568) that upon lipid interaction induce the preceding alpha helix to move out of the active site, which in turn positions phenylalanine 465 into the active site enhancing electron transfer between TPP and FAD [7,8,9]. The phospholipid activation of E. coli Pox is a hybrid of Km-driven (K-type) and velocity-driven (V-type) allosteric activation where the km for pyruvate decreases along with an increase in the enzyme turnover rate . However, in CidC the activation is V-type where the enzyme turnover rate is substantially increased .\nHydrogen peroxide-generating Pox enzymes are produced by multiple different bacteria. Pox enzymes from Lactobacillus plantarum and Streptococcus pneumoniae are the most well studied. These enzymes form homo-tetrameric structures [11, 12]. The role of Pox enzymes in central metabolism is thought to be increasing ATP production in concert with acetate kinase during aerobic metabolism . In S. pneumoniae, which has no tricarboxylic acid (TCA) cycle, additional ATP production from glucose is believed to come from this pathway . L. plantarum Pox is considered to be an important component of the enhanced biomass that is observed in aerobic growth by generating acetyl phosphate as a substrate for acetate kinase . In addition, the production of hydrogen peroxide from Pox could also be important on a community level. Since hydrogen peroxide is toxic to some bacteria, Pox activity could confer a fitness advantage to the producer organism. In S. pneumoniae, pox-deficient mutants display decreased virulence in a rat model of disease likely through decreased adhesion properties, but also potentially through decreased competition with commensal bacteria . Streptococcus gordonii and Streptococcus sanguinis are known to produce enough hydrogen peroxide primarily through Pox to inhibit the oral pathogen Streptococcus mutans . Recently, Lactobacillus delbrueckii strains harboring intact pox genes were shown to produce enough hydrogen peroxide to inhibit the growth of the oral pathogen Porphyromonas gingivalis . The characterization of hydrogen peroxide-producing strains and their respective encoded hydrogen peroxide-producing enzymes could be beneficial in the development of novel treatments for diseases like periodontitis.\nIn the current study, we characterize a hydrogen peroxide-producing Pox enzyme from L. delbrueckii that is catalytically activated specifically by phosphotidylethanolamine, a common bacterial membrane component. This activation is largely dependent on the C-terminal region of the protein. Further, we showed that the L. delbrueckii Pox adopts a pentameric structure and potentially a dimer of pentamers, which is novel for Pox enzymes. These characteristics are unique for hydrogenperoxide-producing Pox enzymes and demonstrate substantial variability in the structure and function of Pox from different bacterial species.\nCharacterization of L. delbrueckii pox\nThe E. coli Pox has been well studied, and it is known that this enzyme is catalytically activated by phospholipids [6, 7, 17]. In addition, CidC and PQO from S. aureus and C. gluticaticum, respectively, are other pyruvate oxidases that are lipid activated [3, 5]. Another well studied Pox enzyme is from Lactobacillus plantarum [1, 13, 18]. This enzyme has not been shown to be catalytically activated by phospholipids indicating that there is variability in the catalytic activation of the Pox enzymes. Amino acid identity between the enzymes ranges from 25.9% between L. plantarum Pox and PQO to 46.4% between E. coli Pox and PQO (Table 1). For DNA sequence identity, the identity ranges from 50.7% between CidC and PQO to 56.3% for CidC and L. plantarum Pox (Table 1).\nFirst, we wanted to determine the biochemical properties of the L. delbrueckii Pox enzyme. We previously purified L. delbrueckii Pox and used it for subsequent testing . We determined the km values for pyruvate and phosphate and the kcat value. The km for pyruvate and phosphate were 342.2 μM and 8 mM respectively, and the kcat was 0.367 s− 1 (Fig. 1 and Table 2). The optimum pH for several other pyruvate oxidase enzymes is near 5.5 and so we tested the activity of the L. delbrueckii Pox at various pHs to determine its pH activity profile. In agreement with other Pox enzymes, the L. delbrueckii Pox was most active at the pH range of 5.5 to 6 (Fig. 1c).\nL. delbrueckii pox forms pentameric structure in solution\nBoth the L. plantarum and E. coli Pox are known to form tetrameric structures [1, 4]. To determine whether the L. delbrueckii Pox also formed a tetramer, we performed gel filtration chromatography with the purified enzyme. Interestingly, L. delbrueckii Pox eluted in two major peaks; the first with a calculated molecular weight of 694 kDa and the second with a calculated molecular weight of 345 kDa (Fig. 2a and b). The molecular weight of an STYM1 L. delbrueckii Pox monomer is 68 kDa according to the translation of the gene sequence; therefore, the first peak corresponded to a decamer and the second peak to a pentamer. The last peak corresponded to unbound FAD (Fig. 2a). Analysis of the fractions by non-reducing SDS-PAGE revealed two distinct bands that migrated distances consistent with monomer and dimer forms of the L. delbrueckii Pox at approximately 68 kDa and 136 kDa (Fig. 2c). Fractions 13 and 14, which correspond to the last peak from gel filtration, did not contain any protein and also were yellow in color confirming the presence of unbound FAD (Fig. 2c). To confirm that the 136 kDa protein band was in fact a dimer of L. delbrueckii Pox, we analyzed the L. delbrueckii Pox on non-reducing and a reducing SDS-PAGE. Under reducing conditions, L. delbrueckii Pox migrated exclusively as a monomer indicating that the 136 kDa band is a dimer, presumably linked by a disulfide bond at position 72 since it is the only cysteine in the amino acid sequence (Fig. 2d).\nPhospholipid activation of L. delbrueckii pox\nWe hypothesized that L. delbrueckii Pox may be activated by phospholipids similar to E. coli Pox, CidC, and PQO [2, 3, 5]. We tested whether addition of either phosphotidylethanolamine (PE), phosphotidylcholine (PC), and phosphotidylglycerol (PG) could catalytically activate L. delbrueckii Pox. L. delbrueckii Pox was catalytically activated specifically by PE, but not PC or PG (Fig. 3a). The phospholipids used contained the same acyl chain structure (16:0–18:1) and only varied in the headgroup indicating that there is specificity in phospholipid activation of L. delbrueckii. To determine the full activation profile of L. delbrueckii Pox by PE, we measured the fold activity over a wider range of PE concentrations and observed activation upwards of 6-fold relative to the enzyme without PE (Fig. 3b). This level of activation exceeds that of the CidC Pox (3-fold activation) from S. aureus .\nTo gain mechanistic insight into how PE activates the enzyme, we tested the kinetic parameters of L. delbrueckii Pox in the presence of PE (Fig. 4). With the addition of PE, the km for pyruvate and phosphate were 519.9 μM and 1.25 mM respectively and the kcat was 6.85 s− 1 (Table 3). The approximately 18-fold increase in kcat and decrease in phosphate km relative to the enzyme in the absence of PE suggest that these parameters are the primary drivers of catalytic activation, which is consistent with the increase in kcat observed in E. coli Pox and CidC upon phospholipid activation [3, 19]. The activation observed here is a hybrid of V- and K-type activation since the kcat increased and the phosphate km decreased, which is also consistent with E. coli Pox [9, 19].\nWe also wanted to determine whether L. delbrueckii Pox inserts into PE micelles. We performed co-precipitation experiments with L. delbrueckii Pox in the presence and absence of PE. Nearly all of the enzyme remained in the soluble fraction and did not co-precipitate with PE, which is in contrast to E. coli Pox  (Fig. 5).\nThe C-terminus of L. delbrueckii pox is important for lipid activation\nThe C-terminus of E. coli Pox is important for lipid activation of the enzyme . To test if the C-terminus was important in the L. delbrueckii Pox, we generated a C-terminal truncation that lacked the last 34 amino acids. We purified the enzyme and tested it for its ability to be activated by PE (Fig. 6a). The enzyme had a specific activity of approximately 1.32 U/mg in the absence of PE, which is greater than the specific activity of the full-length enzyme (Fig. 1c and Fig. 6b). This is consistent with the E. coli pox truncation having greater activity partially mimicking lipid activation . Furthermore, the Δ34 enzyme was only weakly activated by PE to approximately 2-fold greater than the enzyme without PE compared to an approximately 6-fold activation with the full-length enzyme (Fig. 3b and Fig. 6c). This indicates that the C-terminal sequence is important for the lipid activation of the Pox enzyme.\nHere, we demonstrated that the hydrogen peroxide-producing pyruvate oxidase enzyme from L. delbrueckii is catalytically activated specifically by PE, but not other phospholipids, and the last 34 amino acids of the enzyme are important for this activation. To our knowledge, this is the first hydrogenperoxide-producing Pox enzyme that has been shown to be activated by phospholipids. In addition, we showed that the L. delbrueckii Pox forms a pentameric structure in solution of which at least two subunits form a disulfide bond between cysteine 72. Other Pox enzymes form tetrameric structures, and there has been no evidence of disulfide bond formation indicating that the L. delbrueckii Pox has a different structure than other Pox enzymes [1, 4].\nIt is interesting that only PE had an impact on catalytic activity. This suggests that the size, shape, and charge of the phospholipid head group is important for catalytic activation. If the Pox enzyme is interacting with phospholipid that is already incorporated into the membrane, the head group would be exposed to the cytoplasm and be in the closest proximity to the enzyme. The interaction with the cytoplasm-facing ethanolamine likely occurs through the C-terminal 34 amino acids. Similar to the E. coli Pox, we hypothesize that this interaction induces a conformational shift in the enzyme that enhances electron transfer between FAD and TPP and decreases the phosphate km. This interaction is likely mediated by electrostatic forces. In fact, it is believed that CidC interaction with phospholipids is driven primarily by electrostatic forces suggesting there is interaction with the headgroup . Furthermore, PE is known to be an abundant component of bacterial membranes, whereas PC is more commonly a eukaryotic and mammalian membrane component [21, 22]. Thus, activation only by PE is reasonable since L. delbrueckii Pox is a bacterial enzyme. Enhanced hydrogen peroxide production by L. delbrueckii could be beneficial in a complex microbial community. In fact, hydrogen peroxide production by Pox has been shown to be important in the inhibition of dental pathogens like P. gingivalis .\nThe pentameric structure of L. delbrueckii Pox is different from what has been observed with E. coli Pox and L. plantarum Pox [1, 4]. Based on our gel filtration data, the L. delbrueckii also forms a decamer or a dimer of pentamers, but it is unclear which of these may be occurring. Interestingly, we also observed formation of dimers linked by a disulfide bond which are a component of the pentameric structure since they were present in fractions with an elution volume consistent with pentameric molecular weight. Therefore, the structure of the pentamer must be comprised of either three monomers and one dimer or one monomer and two dimers.\nE. coli Pox lipid activation is a mixture of K- and V-type allosteric activation where the pyruvate Km decreases and the kcat increases [19, 23]. The lipid activation observed with L. delbrueckii Pox was also a mixture of K- and V-type allosteric activation, however, the specific parameters that changed were different. The pyruvate km increased slightly while the phosphate km decreased. The Kcat did increase substantially (18-fold) similar to the E. coli Pox. Since the changes in pyruvate and phosphate km could offset one another, we believe that the lipid activation of L. delbrueckii Pox is primarily driven by increasing the enzyme turnover rate. This is consistent with structural data of E. coli Pox demonstrating that lipid activation’s primary effect on the enzyme is to shift a phenylalanine closer to the interface between TPP and FAD to increase the efficiency of electron transfer . This is thought to increase the enzyme turnover rate substantially. It is also in agreement with the activation of CidC where the activation of the enzyme was exclusively driven by a 10-fold increase in kcat .\nE. coli Pox, CidC, and PQO are the only known lipid-activated Pox enzymes [3, 5, 7]. These Pox enzymes likely evolved this ability so that they are most active near or at the membrane where it can readily transfer electrons to a membrane electron shuttle [3, 9]. For this reason, E. coli Pox inserts and co-precipitates with lipids in the presence of substrate . Likewise, the CidC pyruvate oxidase from S. aureus interacts with phospholipids, but the interaction is believed to be mediated by electrostatic forces indicating that there does not necessarily need to be insertion into the membrane . We did not observe any co-precipitation of L. delbrueckii Pox with PE suggesting that there is no insertion or that the interaction may be unable to withstand centrifugal forces. The fact that L. delbrueckii Pox does not strongly associate with or insert into the membrane may be a mechanism to regulate hydrogen peroxide production. If the association were too strong or there was insertion into the membrane, excessive hydrogen peroxide production may intoxicate the cell.\nL. delbrueckii Pox does not need to interact with the membrane since it does not transfer electrons to a membrane electron shuttle, but rather to oxygen. Therefore, the utility of lipid activation of L. delbrueckii Pox is less clear than it is for other pyruvate oxidase enzymes that transfer electrons to membrane-bound carriers. One hypothesis is that the lipid activation of a hydrogen peroxide-producing Pox could be beneficial because it would position hydrogen peroxide production at a peripheral point of the cell. Passive diffusion of hydrogen peroxide from this point would subject the interior of the cell to less hydrogen peroxide and excrete more through the membrane than if the enzyme were positioned in the middle of the cell. Thus, the lipid activation of the Pox enzyme in this case may reduce the self-toxicity of hydrogen peroxide production by L. delbrueckii by activating the enzyme only at the edges of the cell.\nIn this report, we describe the first hydrogen peroxide-producing Pox enzyme that is activated by the phospholipid phosphotidylethanolamine. We also demonstrated a different oligomeric structure than other known Pox enzymes. Together, these data demonstrate that Pox enzymes from different bacterial species can vary in their structure and function. As Pox is an important enzyme in mediating bacterial interactions and microbial community structure, enhancing pathogenicity, and for certain biosensor applications, further understanding of the biochemical characteristics of Pox are warranted.\nPyruvate oxidase enzyme or pyruvate:oxygen 2-oxidoreductase (phosphorylating) (EC 18.104.22.168) was derived from Lactobacillus delbrueckii STYM1 strain . The pyruvate oxidase enzyme was purified as previously described .\nPurification of L. delbrueckii pox Δ34\nThe L. delbrueckii pox deletion mutant was PCR amplified from STYM1 genomic DNA using the primers listed in Table 4. The PCR product was ligated into the pFLAG-CTC vector (Sigma, St. Louis, MO) using the NdeI and XhoI (New England Biolabs, Ipswich, MA) restriction sites. The product was transformed into DH5α E. coli and the construct was confirmed by PCR and sequencing. The construct was transformed into LOBSTR E. coli (Kerafast, Boston, MA), in which the L. delbrueckii Δ34 Pox was expressed as a C-terminal His6-Pox. A starter culture was diluted 1:100 into 40 mL of LB supplemented with 100 μg/mL of carbenicillin (Sigma, St. Louis, MO) and grown at 37 °C until the OD600 reached 0.4–0.8. The cells were cooled on ice for 10 min and 1 mM isopropyl-β-D-thiogalactopyranoside (IPTG) (Sigma, St. Louis, MO) was added and the cells incubated at 25 °C with shaking for 20 h. The cells were harvested by centrifugation at 3200 x g for 20 min at 4 °C and resuspended in 1 mL 20 mM Bis-Tris 150 mM NaCl pH 7 with EDTA-free cOmplete protease inhibitor cocktail (Roche, Basel, Switzerland). The cells were lysed by sonication on ice and the soluble cell lysate was harvested by centrifugation at 16000 x g for 15 min at 4 °C. The soluble cell lysate was filtered through a 0.22 μm polyvinylidene fluoride (PVDF) filter and applied to a 1 mL bed volume of HisPure Ni-NTA resin (Thermofisher, Waltham, MA). The column was washed twice with two column volumes of buffer containing 25 mM imidazole (Fisher, Pittsburgh, PA) and the bound protein was eluted from the column in buffer containing 250 mM imidazole. Protein purity was assessed by SDS-PAGE and Coomassie staining.\nPyruvate oxidase activity assay and kinetic parameters\nPyruvate oxidase activity was measured as previously described . Briefly, 50 mM sodium pyruvate, 15 μM FAD (Sigma, St. Louis, MO), 300 μM TPP (Sigma, St. Louis, MO), 0.03% N-ethyl-N-(2-hydroxy-3-sulfopropyl)-m-toluidine (Sigma, St. Louis, MO), 0.015% 4-aminoantipyrine (Sigma, St. Louis, MO), and 33 μg/mL horseradish peroxidase (Sigma, St. Louis, MO) were combined with purified pox enzyme. After a 10-min incubation at room temperature, sodium phosphate pH 5.6 was added to 50 mM final concentration to initiate the reaction. The formation of a quinoneimine dye at 25 °C was measured by an increase in absorbance at 550 nm and the specific activity was calculated as described. 1 unit of Pox activity is defined as the production of 1 μmol of hydrogen peroxide per minute and this was converted to μM/min for kinetic analysis.\nFor km determination of pyruvate and phosphate and determination of kcat, dilutions of substrate were used instead of the 50 mM concentration. Enzyme concentration was 1.76 μM. V0 for each substrate concentration was plotted and the data were fitted using Prism software (Graphpad, San Diego, CA) kcat non-linear regression function. For km and kcat determination in the presence of phosphotidylethanolamine (PE), PE was used at a concentration of 7.2 mM and the enzyme concentration was 170 nM.\nPhospholipid activation assay\nPhosphotidylethanolamine (16:0–18:1) (Avanti Lipids, Alabaster, AL), Phosphotidylcholine (16:0–18:1) (Avanti Lipids, Alabaster, AL), and Phosphotidylglycerol (16:0–18:1) (Avanti Lipids, Alabaster, AL) dissolved in chloroform were purchased commercially at a concentration of 10 mg/mL. The desired volume of 10 mg/mL phospholipid solution was evaporated under a steady stream of argon gas (Airgas, Radnor, PA) and dried in a vacuum desiccator for 1 h to evaporate residual chloroform and yield the desired weight of dried phospholipid. The phospholipids were resuspended in the appropriate volume of 20 mM Bis-Tris 150 mM NaCl pH 6 to achieve the desired concentration and incubated at 37 °C with shaking at 225 rpm for 30 min. The suspension was vortexed for 30 s and vortexed immediately prior to each use.\nPhospholipids were added to the pyruvate oxidase assay mixture at various concentrations and enzyme activity was measured as described above. Fold activity was calculated relative to enzyme activity without phospholipid.\nGel filtration analysis\nPrior to analysis of the L. delbrueckii Pox, protein standards were mixed together and applied to the Superdex 200 column (GE healthcare, Chicago, IL) using a duo-flow system (Biorad, Hercules, CA). The protein standards were thyroglobulin (670 kDa), gamma-globulin (150 kDa), ovalbumin (44 kDa), myoglobulin (17 kDa), and vitamin B12 (1.35 kDa). Protein was eluted from the column using a mobile phase of 20 mM Bis-Tris pH 6150 mM NaCl at 0.5 mL/min flow rate. A standard curve was plotted using the peak elution volume for each standard versus the Log10 of the molecular weight in daltons. Eight hundred forty μg of purified L. delbrueckii Pox was incubated in the presence of 50 mM pyruvate, 300 μM TPP, and 15 μM FAD for 10 min at room temperature prior to application to the column. The absorbance at 280 nm was recorded over the elution. One mL fractions were collected after the void volume of 10 mL until the end of the elution. The peak volume for the Pox fractions was used to calculate the molecular weight according to the standard curve.\nL. delbrueckii Pox in each fraction from gel filtration was visualized after non-reducing SDS-PAGE analysis with Coomassie staining. For reducing SDS-PAGE analysis, 5% β-mercaptoethanol (Sigma, St. Louis, MO) was included in the sample buffer.\nPE was prepared as described above for activation experiments. 3 μg of L. delbrueckii Pox was incubated with 50 mM pyruvate, 300 μM TPP, and 15 μM FAD with either 1 mM PE or no PE for 30 min at room temperature. The PE fraction was precipitated by centrifugation at 16,000 x g for 20 min at 4 °C. The supernatant was aspirated as the soluble fraction and the PE pellet was resuspened in an equal amount of buffer. The fractions were visualized by Coomassie staining after SDS-PAGE.\nAvailability of data and materials\nAll data generated or analyzed during this study are included in this published article. Raw data can be made available upon request from the corresponding author.\nFlavin adenine dinucleotide\nSedewitz B, Schleifer KH, Götz F. Purification and biochemical characterization of pyruvate oxidase from Lactobacillus plantarum. J Bacteriol. 1984;160(1):273–8.\nCunningham CC, Hager LP. Reactivation of the lipid-depleted pyruvate oxidase system from Escherichia coli with cell envelope neutral lipids. J Biol Chem. 1975;250(18):7139–46.\nZhang X, Bayles KW, Luca S. Staphylococcus aureus CidC is a pyruvate:Menaquinone Oxidoreductase. Biochemistry. 2017;56(36):4819–29.\nWang AY, Chang YY, Cronan JE. Role of the tetrameric structure of Escherichia coli pyruvate oxidase in enzyme activation and lipid binding. J Biol Chem. 1991;266(17):10959–66.\nSchreiner ME, Eikmanns BJ. Pyruvate:Quinone Oxidoreductase from Corynebacterium glutamicum: purification and biochemical characterization. J Bacteriol. 2005;187(3):862–71.\nChang Y-Y, Cronan JE. An Escherichia coli mutant deficient in pyruvate oxidase activity due to altered phospholipid activation of the enzyme. Proc Natl Acad Sci. 1984;81(14):4348–52.\nGrabau C, Chang YY, Cronan JE. Lipid binding by Escherichia coli pyruvate oxidase is disrupted by small alterations of the carboxyl-terminal region. J Biol Chem. 1989;264(21):12510–9.\nCunningham CC, Hager LP. Crystalline pyruvate oxidase from Escherichia coli III. PHOSPHOLIPID AS AN ALLOSTERIC EFFECTOR FOR THE ENZYME. J Biol Chem. 1971;246(6):1583–9.\nNeumann P, Weidner A, Pech A, Stubbs MT, Tittmann K. Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli. Proc Natl Acad Sci. 2008;105(45):17390–5.\nTaniai H, Iida K, Seki M, Saito M, Shiota S, Nakayama H, et al. Concerted action of lactate oxidase and pyruvate oxidase in aerobic growth of Streptococcus pneumoniae: role of lactate as an energy source. J Bacteriol. 2008;190(10):3572–9.\nMuller YA, Schulz GE. Structure of the thiamine- and flavin-dependent enzyme pyruvate oxidase. Science. 1993;259(5097):965–7.\nRamos-Montañez S, Tsui H-CT, Wayne KJ, Morris JL, Peters LE, Zhang F, et al. Polymorphism and regulation of the spxB (pyruvate oxidase) virulence factor gene by a CBS-HotDog domain protein (SpxR) in serotype 2 Streptococcus pneumoniae. Mol Microbiol. 2008;67(4):729–46.\nLorquet F, Goffin P, Muscariello L, Baudry J-B, Ladero V, Sacco M, et al. Characterization and functional analysis of the poxB gene, which encodes pyruvate oxidase in Lactobacillus plantarum. J Bacteriol. 2004;186(12):3749–59.\nSpellerberg B, Cundell DR, Sandros J, Pearce BJ, Idänpään-Heikkilä I, Rosenow C, et al. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Mol Microbiol. 1996;19(4):803–13.\nKreth J, Zhang Y, Herzberg MC. Streptococcal antagonism in Oral biofilms: Streptococcus sanguinis and Streptococcus gordonii interference with Streptococcus mutans. J Bacteriol. 2008 Jul 1;190(13):4632–40.\nCornacchione LP, Klein BA, Duncan MJ, Hu LT. Interspecies inhibition of Porphyromonas gingivalis by yogurt-derived Lactobacillus delbrueckii require active pyruvate oxidase. Appl Environ Microbiol. 2019;85(18):01271–19.\nGrabau C, Cronan JE. In vivo function of Escherichia coli pyruvate oxidase specifically requires a functional lipid binding site. Biochemistry. 1986;25(13):3748–51.\nRisse B, Stempfer G, Rudolph R, Möllering H, Jaenicke R. Stability and reconstitution of pyruvate oxidase from lactobacillus plantarum: dissection of the stabilizing effects of coenzyme binding and subunit interaction. Protein Sci. 1992;1(12):1699–709.\nBertagnolli BL, Hager LP. Activation of Escherichia coli pyruvate oxidase enhances the oxidation of hydroxyethylthiamin pyrophosphate. J Biol Chem. 1991;266(16):10168–73.\nRecny MA, Grabau C, Cronan JE, Hager LP. Characterization of the alpha-peptide released upon protease activation of pyruvate oxidase. J Biol Chem. 1985;260(26):14287–91.\nVance JE. Phospholipid synthesis and transport in mammalian cells. Traffic. 2015;16(1):1–18.\nZhang Y-M, Rock CO. Membrane lipid homeostasis in bacteria. Nat Rev Microbiol. 2008;6(3):222–33.\nMather MW, Gennis RB. Kinetic studies of the lipid-activated pyruvate oxidase flavoprotein of Escherichia coli. J Biol Chem. 1985;260(30):16148–55.\nThis work was funded by the NIH/NIDCR R01 DE024308 (to L.T.H) and F31 DE025523 (to L.P.C). The funding agencies had no role in the design of the study, data collection, analysis, interpretation of data, or in writing the manuscript.\nEthics approval and consent to participate\nConsent for publication\nThe authors declare that they have no competing interests.\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.\nAbout this article\nCite this article\nCornacchione, L.P., Hu, L.T. Hydrogen peroxide-producing pyruvate oxidase from Lactobacillus delbrueckii is catalytically activated by phosphotidylethanolamine. BMC Microbiol 20, 128 (2020). https://doi.org/10.1186/s12866-020-01788-6\n- Catalytic activation\n- Hydrogen peroxide\n- Lactobacillus delbrueckii\n- Pyruvate oxidase", "label": "Yes"}
{"text": "Doctor insights on:\nI Have Symptoms Of Pregnancy\nCould i be pregnant? I have been experiencing of what seems like early pregnancy symptoms. Bloating of abdomen and shortness of breath.\nPregnancy Sxs: Sxs can include: tender or swollen breasts, nausea or vomiting; lack of a period; increased frequency of urination; headaches, insomnia, fatigue. Moodiness, mild cramping, food cravings; passing gas; enlarging waist line. Etc. There may be an increase in white vaginal discharge. The best way to determine if you are pregnant is by taking a pregnancy test. You can take a pregnancy test now. ...Read more\nWhen your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more\nTalk to Someone: Be sure to talk with your physician or other provider about your mood. It may be helpful for you to seek out therapy or counseling. You also want to try to have a good support system in place. Medications are sometimes considered for depression during pregnancy, but usually only in more severe cases. ...Read more\nA positive preg test: In today's world there is no real reason to try to guess whether or not you are pregnant based on symptoms. If you are wondering if you are pregnant or not then simply take an over the counter pregnancy test. They are cheap and reliable and then you will have your answer. ...Read more\nI have pregnancy symptoms, tested negative and have a period but the symptoms are still here except the sore breast?\nIm stressed and believe im pregnant I have all the classic symptoms of being pregnant so is there a chance im still pregnant with these symptoms?\nWait 10 days...: Millions of women get pregnant every week in the world... A completely natural event, so no worrying is needed. Just do something else for 10 days, and on the 10th day do another urine pregnancy test from the drugstore. If it's done and read correctly, it's very accurate. If the test is negative, but a period doesn't occur the next month, have the ob-gyn evaluate to figure things out. ...Read more\nI have taken 2 pregnancy test and they both came back negative, I am still having symptoms of pregnancy, could i still be pregnant for the last week and a half I have been having symptoms of pregnancy. I have been nauseous, I have fatigue, mood swings, fo\nIt : It depends on whether you have missed your period and when you took your tests. As doctors, anytime a fertile, sexually active woman has an abnormally light or missed period, the first thing we do is rule out pregnancy. You can either take another home pregnancy test as long as it has been 5- 6 weeks since your last normal period, or you can go see your doctor and they can test you. A home pregnancy test is 97% accurate if taken a week or more after the missed period, so another negative test would help confirm that you are not pregnant. A blood test can tell if you are pregnant as soon as 7 days after conception and a doctor's urine pregnancy test can tell if you are pregnant around when you next period should come. ...Read more\nI have taken pregnancy tests and all are negative but I have symtoms of a pregnancy but i also have a UTI (5 months) how do I know what to aspect?\nBack to School?: A woman who is truly pregnant has no symptoms. The baby, once conceived is not in any way connected to the mother until it is grown big enough to be sharing chemicals and blood with the mother. That takes about fourteen days. Any symptoms before then are known as pre-menstrual. Or they are related to hormones. The tests all tell you that you are not pregnant. Treat your uti. ...Read more\nSee a doctor: Have no idea what you have since do not know the history or the symptoms which you are describing. Go see a doctor and get examined and tested and treated if necessary. Get better soon. ...Read more\nI am having most of the pregnancy symptoms, my period is due any day, I have taken 3 home pregnancy tests and all negative, could i be pregnant?\nI have been having the early symptoms of pregnancy, my period is one week late today, I have also had dreams of being pregnant . Could I be pregnant?\n5 weeks pregnant..Very scared of ectopic pregnancy I have slight cramping ..no bleeding...I have other children..what are the symptoms?\nCould i be pregnant if I have most signs and symptonms of pregnancy? Could i be pregnant if I have most signs and symptoms of pregnancy?, like bloating, cramps, frequent urination, fatigue more than normal, breast tenderness/soreness, eating and craving w\nThe : The simple answer here is to schedule a visit with your doctor. A pregnancy test can be done via serum (blood). This will give a definitive answer (positive or negative). If the test is negative then additional work up may need to be done in order to evaluate your symptoms, including urine testing to rule out uti, thyroid testing, and possibly a pelvic ultrasound to rule out uterine fibroids (benign tumors of uterus). Your doctor may recommend starting a birth control pill to regulate your cycle and symptoms. Best of luck. ...Read more\nOk I am scared i might be pregnant and I have the meirana IUD in and I have been having symptoms of pregnancy but the home tests are reading neg!?\nNeg test = not preg: Home pregnancy tests are very accurate. They are the same tests used in a doctors office. They can detect a pregnancy 7-10 days after conception. The best time to take one is when you miss your period. If you doubt the result you can repeat it in 1-2 days. If you were pregnant the hormone level would rise enough for detection. ...Read more\nI have bloating, back pains, very small signs of spotting but no period... What are the signs of pregnancy?\nCheck preg test: Home pregnancy tests are very accurate. They are the same tests used in a doctors office. They can detect a pregnancy 7-10 days after conception. The best time to take one is when you miss your period. If you doubt the result you can repeat it in 1-2 days. If you were pregnant the hormone level would rise enough for detection. The vaginal discharge requires testing. ...Read more\nHormones: Hormones can cause some of those symptoms. There is a new article from dr. Paulman describing cases where thinking about and wishing for a baby changed hormone levels. This then caused symptoms consistent with pregnancy. The other possibility is vaginal bleeding which occurs in 25% of pregnancies and can at times be heavy or appear regular. Your doctor can evaluate your symptoms. ...Read more\nHow accurate is home pregnant tests? Both were negative. What are signs of having a cyst? I have all signs of pregnancy but just started period i believe.\nMissed 2 and half months of my period. Negative pregnancy test but im having a lot of pregnancy symptoms. By the way i have pcos. Could i be pregnant?\nMaybe: Its also likely your symptoms are due to not ovulating. If you go more than 3 months without a period, you may have very heavy prolonged flow. I would schedule an appointment with your physician or GYN and get some provera (medroxyprogesterone) and ask for a serum pregnancy test as well. ...Read more\nI have all the symtoms of being pregnant but I have cramps in ovary's that can last minutes at a time? Could I be pregnant?\n- Talk to a doctor live online for free\n- I have all symptoms of pregnancy but negative test\n- I'm having pregnancy symptoms but im not pregnant\n- Should i have pregnancy symptoms at 4 weeks\n- Ask a doctor a question free online\n- Why do i have pregnancy symptoms and not pregnant?\n- Why am i having pregnancy symptoms but not pregnant?\n- I have all the symptoms of pregnancy but im bleeding\n- I have all pregnancy symptoms but negative test\n- Talk to a obstetrician and gynecologist online", "label": "Yes"}
{"text": "Pharmacokinetic (PK) has improved our knowledge about the most appropriate dosing and timing of administration of FVIII/FIX concentrates in patients with Haemophilia. However, although several studies have recently addressed the relevance of PK of clotting factors, usual practice is still mostly based on empiric approaches since individual PK estimation is difficult to obtain unless the patient is formally enrolled in a study. In fact, several plasma samples collected over several hours and/or days are required to establish a half-life curve confidently and this may be a relevant problem, especially in children. Recently however population PKs has emerged as an important tool to overcome this drawback. Targeted prophylaxis could take advantage of knowing the individual response to factor concentrate administration. On the clinical ground, age and body weight (BW) are roughly used to guide dosing because usually in vivo recovery is lower and clearance is faster in children than in adults.\nKeywords: Factor VIII, Factor IX, Haemophilia A, Haemophilia B, Pharmacokinetics.", "label": "Yes"}
{"text": "Individual differences |\nMethods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |\nBiological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)\nStudies concerning genetic association aim to test whether single-locus alleles or genotype frequencies (or more generally, multilocus haplotype frequencies) are different between 2 groups (usually diseased subjects and healthy controls). Genetic association studies are based on the principle that genotypes are measured \"directly\", i.e. by sequencing the actual genetic code.", "label": "Yes"}
{"text": "Thanks to successful research, three forms of liver disease – hepatitis A, B and D* – can be prevented by immunization.\n*although there is no specific vaccine for hepatitis D, being immunized against hepatitis B will prevent you from contracting hepatitis D.\nHepatitis A is a serious liver disease caused by a virus that attacks the liver. The virus is transmitted through contaminated food, such as raw or insufficiently cooked shellfish and contaminated water. It can be passed by someone infected with the virus who doesn’t wash his/her hands properly after a bowel movement and then touches something that you eat.\nThe good news is that hepatitis A can be prevented by vaccination. A variety of vaccines are available to make immunization fit your needs. The vaccine will prevent you from contracting hepatitis A and from being a potential source of infection to others.\nIf you are planning to travel to destinations such as Mexico, the Caribbean, Africa, Asia, Latin America or Eastern Europe, you should get vaccinated against hepatitis A. These areas can be high risk for hepatitis A due to improper food handling and preparation and inadequate sewage and water purification systems. You do not necessarily need to be vaccinated if you are travelling in Canada, the U.S., Western Europe, Australia, New Zealand or Japan. In the past several years however, there have been hepatitis A outbreaks or alerts in North America due to contaminated produce used in a restaurant or sold in a supermarket and an infected individual involved in food preparation or food serving. The hepatitis A vaccination should also be considered for those who work in day-care settings and especially those who diaper infants.\nThere are several different hepatitis A vaccines licensed for use in Canada. These vaccines are well-tolerated and are at least 85-90 percent effective in preventing hepatitis A. Adverse reactions are generally mild and short-lived and may include reactions at the injection site, including pain, redness and swelling.\nFor more information on the hepatitis A vaccination, please consult your doctor.\nHepatitis B is another form of liver disease caused by a virus that attacks the liver. The hepatitis B virus is 100 times more contagious than the virus that causes AIDS. It is spread through infected blood or body fluids or by sexual contact with an infected person. Hepatitis B is not spread by water, food or through casual contact.\nLike hepatitis A, hepatitis B is also preventable by vaccine. Three injections of this vaccine within a six-month period provide long-lasting protection against hepatitis in the majority of people. People most at risk are those whose jobs may expose them to blood or body fluids ( i.e. firefighters, health care professionals, law enforcement officers, etc.), sexual partners of hepatitis B carriers and babies born to mothers who are hepatitis B carriers. Immigrants from countries where hepatitis B is common (i.e. Asia, Southern and Eastern Europe, sub-Saharan Africa and the Pacific Islands) also carry greater risk.\nIn Canada, there are hepatitis B vaccines licensed for use in adults and separate formulations for use in children. There is also a combined hepatitis A and B vaccine available.\nThe above mentioned vaccines are generally well tolerated by adults and children, with a few mild and transient adverse effects. The most common adverse effects include pain, soreness and redness at the injection site and mildly elevated temperature.\nMost Canadian provinces and territories provide universal hepatitis B vaccination programs for school-aged and pre-teen children. These vaccinations are usually offered to children in grades 5 to 7 depending upon the province.\nFor more information on the hepatitis B immunization, please contact your doctor or public health nurse.\nFor those who have had recent contact (seven days or less) with infected blood or body fluids, immunization with the hepatitis B immune globulin may be effective in preventing an acute form of the illness.\nInfants born to mothers infected with the hepatitis B will receive hepatitis B immune globulin at birth as well as the first of three doses of the hepatitis B vaccine. These infants will receive the second dose at one month and the third at six months of age. This treatment will give the baby a 95 percent chance of not becoming infected with the hepatitis B virus.\nAt this time, there is no vaccine for hepatitis C. However, all people with chronic liver disease, including hepatitis C, should be immunized against both hepatitis A and B. A second infection by either virus can compound the damage to your liver. For those whose hepatitis C is more advanced, drug treatment may be appropriate and must be administered after careful assessment by your physician.", "label": "Yes"}
{"text": "Skin cancer incidence has increased exponentially over the last three decades. In 2008 skin cancer caused 2280 deaths in the UK, with 2067 due to malignant melanoma. Early diagnosis can prevent mortality, however, conventional treatment requires multiple procedures and increasing treatment times. Second harmonic generation (SHG) imaging could offer diagnosis and demarcation of melanoma borders non-invasively at presentation thereby short-cutting the excision biopsy stage. To test the efficacy and accuracy of SHG imaging of collagen in skin and to delineate the borders of skin cancers, unstained human melanoma biopsy sections were imaged using SHG microscopy. Comparisons with sister sections, stained with H&E or Melan-A were made for correlation of invasion borders. Fresh ex vivo normal human and rat skin was imaged through its whole thickness using SHG to demonstrate this technique is transferable to in vivo tissues. SHG imaging demonstrated detailed collagen distribution in normal skin, with total absence of SHG signal (fibrillar collagen) within the melanoma-invaded tissue. The presence or absence of signal changes dramatically at the borders of the melanoma, accurately demarcating the edges that strongly correlated with H&E and Melan-A defined borders (p<0.002). SHG imaging of ex vivo human and rat skin demonstrated collagen architecture could be imaged through the full thickness of the skin. We propose that SHG imaging could be used for diagnosis and accurate demarcation of melanoma borders on presentation and therefore potentially reduce mortality rates.\n© 2011 OSA\nSkin cancer is one of the most common forms of cancer in the UK totaling around 84,500 registered cases in 2007 with 10,672 case of these being malignant melanoma (MM) [1–5]. The total cost of skin cancer in the UK in 2002 was estimated to be in excess of £190 million . In that year, 63% of the total costs of skin cancer were attributable to MM alone, amounting to 1770 cases  and the number continues to rise (1852 in 2006), resulting in a doubling of reported cases since the early 1970’s (Quinn et al., 2001).\nGlobally, there were more than 161,000 reports of MM alone in 2002, with Australia/New Zealand having the highest incidence followed by Northern America, Northern Europe and Western Europe (67, 27.1, 18.5 and 17.6 cases/100,000, respectively) . These numbers are predicted to continue rise over the next few decades. Although MM becomes more common with increasing age, these trends have changed more recently with an abnormally high incidence in the young; with MM becoming the most common form of cancer in people aged 15-34, a 300% increase between 1975 and 2006 . The greatest increase was found in the 60-79 year old group, particularly in males, which has seen an increase of over 600% in the same period .\nEarly diagnosis and treatment can prevent death for the majority of these patients. The normal route for diagnosis is a Post-Hoc method that builds-in an inherent delay in the diagnostic procedure. This involves histological processing of the tissue followed by analysis/diagnosis by an expert pathologist to assess the severity of the MM and the margins of the invading cancer cells based on Breslow thickness measurements. This may result in the patient having to undergo two or more operations to surgically remove the entire tumour, if some of the affected tissue was not removed at the first biopsy stage. For irregular shaped cancers, simply applying Breslow depth measurements to calculate the margins of the cancer to excise the lesion is inadequate and results in further excision biopsies being necessary to remove all the diseased tissue. This delay can lead to the cancer metastasizing to other tissues and significantly worsen the prognosis for the patient.\nDuring their invasion of surrounding tissues, both Melanoma and Non-Melanoma Skin Cancer (NMSC) utilize the same biological events [8–13]. They are characterized by active invasion and destruction of surrounding connective tissue. Penetration of the cancer through the basement membrane (BM) is the initial step in the complex process of invasion and metastasis. This process when simplified consists of three distinct events: 1. attachment to the BM, via various cell surface receptors. 2. degradation of the BM and extracellular matrix by a series of matrix metalloproteinases (MMPs). 3. cancer cell locomotion into the surrounding tissue induced by chemotaxis. Therefore, a key features of all skin cancers is the degrading and remodeling of the extracellular matrix along the borders of the invading cancer, principally collagen type I, by matrix MMPs [8–13], but little is known about the differential disruption of collagen density and morphology between MM and NMSC . We propose that this degradation of collagen along the borders of the invading cancer can be used to, a) accurately define the margins of the skin cancer, and b) aide in the diagnosis of a malignant condition.\nConfocal microscopy has been the subject of intensive investigation in the scientific community in recent years, not least in the field of cancer biology [14,15]. More recently, multiphoton fluorescence microscopy (MPFM) has been used for non-invasive imaging of the epidermis in a number of studies [16,17]. Since MPFM is a non-linear fluorescence phenomenon, only tissues at the focal point of the objective are excited and hence the technique is inherently confocal, i.e., the only two-photon events that can occur in the tissue will be at the focal point of the objective and therefore no confocal pinhole is required to remove out-of-focus blur. Similarly, second harmonic generation (SHG) occurs only at the focal point of the objective in tissues that have a non-centrosymmetric crystalline structure, such as collagen, to produce a strong SHG signal at exactly half the wavelength of pump laser wavelength [18–21]. However, with SHG imaging, there is substantially less absorption of energy by the tissue compared to single-photon excitation if the fundamental wavelength is off the resonance wavelength of cellular constituents, and hence, there is negligible thermal or phototoxic damage . As both SHG and MPFM utilize pulsed infra-red light this allows deep imaging into live tissues (400–1000 µm depending tissue turbidity, pigmentation and wavelength) with less scattering of light [15,22,23]. Importantly, the SHG signal is generated without the need to stain the tissue in any way, and so this technique lends itself well to be used as a non-invasive imaging tool [24,25]. Using second harmonic confocal microscopy we have demonstrated that the borders of malignant skin cancers can be easily identified in unstained human biopsy skin sections that correlate well with clinical diagnosis of MM.\nWe propose that by using SHG imaging the diagnostic process currently used and surgical planning can be dramatically enhanced by accurately delineating the borders of invading cancer cells at the patient’s first presentation. This could significantly reduce the time taken for diagnosis and alleviate the patient of repeated operations and possibly decrease mortality rates.\n2. Materials and methods\nSections from human MM biopsies were acquired from the University of Szeged, Hungary with full ethical approval from the host institute and patient consent. Tissue devitalization protocols were standardized for all patients and no samples showed any signs of necrosis prior to excision. Histological preparation of the tissue was identical for all samples. Five samples were diagnosed as superficial spreading MM, one nodular MM and two lentigo mailgnia MM. Three samples were from female patients and five from males with an age range of 58–75 years. Breslow thickness assessments ranged from 0.304 to 1.672 mm and post-MM excision survival was 30–84 months.\nMultiple adjacent fields of unstained human melanoma skin sections (4µm) (n = 8 patients) were imaged using SHG imaging to reveal fibrillar collagen distribution (principally Type I and III), followed by single-photon transmission (bright field) imaging. A detailed description of the experimental setup is described in . Image acquisition was performed on a Leica SP2 AOBS confocal multi-photon laser scanning microscope coupled to a Leica DMRE upright microscope (Leica, Milton Keynes, UK), equipped with a pulsed, mode locked femtosecond (fs) Ti:sapphire Tsunami laser synchronously pumped by a Millenia VII (Spectra-Physics, Mountain View CA), diode pumped solid state frequency doubled laser capable of delivering up to 8.5W pumping power at 532nm.\nAll SHG image acquisition was performed at 880nm, which has previously been found to be the optimum wavelength for collagen types I and III . The pulse width of the Tsunami was 80 fs with a pulse repetition rate of 80 Mhz. Laser power output at the microscope objective was recorded with a coherent power meter and calibrated for all samples to deliver peak power of 0.4 × 108 Wcm−2 and was consistently maintained below the damage threshold of the samples, which for collagen in sections was found to be 1.5 × 108 Wcm−2 . An IST laser spectrum analyzer coupled to a Tektronix TDS 210 oscilloscope was used to tune the laser to the desired wavelength. An electro-optical modulator (EOM) (Linos LIV20) received the laser output before delivery to the confocal microscope through a series of optical mirrors. The EOM allowed the laser intensity at the objective to be controlled and optimized. EOM was set at 90% to circularly polarize the pump laser beam, so as to ensure the incident beam laser remained consistent across all specimens. Thus the potential effects of sample polarization versus fundamental pump beam polarization were minimized.\nIn order to image the complete section we used a motorized stage (Mietzhouser, GmbH), controlled by the Leica software to perform automated montages from multiple fields consisting of up to 42 x 19 fields with up to 10 z-sections of 1µm thickness. Samples were imaged with a 20x, 0.7NA dry objective and 2x zoom producing an image measuring 375 by 375 µm at 512 by 512 pixel resolution. The SHG signal in the backscattered geometry was captured in the de-scanned detector with the pinhole set to the maximum of 600 µm. The Leica microscope incorporates a programmable, prismatic beam splitter, which is capable of single and multi-chromatic beam splitting. The backscattered photons are subsequently focused through the objective lens with an estimated beam diameter of 0.24 µm (λp = 880 nm) and delivered through the prismatic beam splitter, programmed to collect light at 435-445nm, before passing it on to the photomultiplier tube (PMT). This calculation is based on the Guoy phase shift and its relationship to the NA of the objective lens, the fundamental wavelength and refractive index of the sample . Thus the beam diameter = 0.32λ / √2NA. The coherent SHG signal formed in the transmission geometry was detected by the transmission detector via the microscope condenser with 445 nm df 30nm band pass filter inserted in the light path (Chroma Inc. UK). In addition, a non-confocal, bright-field image was acquired (sequentially to the SHG image) using single photon excitation at 488nm, which was collected in the transmission PMT. This image served as a reference image to overlay the H&E or Melan-A with the SHG images during the assessment stage. At the end of image acquisition the automatic montage software produced a final compilation image of the all z-projected fields.\nSister-sections were then imunohistochemically stained for the melanoma marker, Melan-A, and imaged using conventional light microscopy, then overlaid on the SHG images for comparison. The extent of invasion and limits of the borders between the two imaging techniques (H&E and or Melan-A) was assessed and marked by two independent histopathologists. The lateral boarders of cancer invasion were marked on the SHG images by an independent researcher, blinded to the histopathologists assessments, then checked for the degree of correlation between the SHG and H&E/Melan-A findings, using Mann-Whitney U-Test and Kendall-Rank Correlation Analysis. The criteria used for the independent evaluation of the MM borders of the SHG images were that one could clearly discriminate undisrupted collagen fiber bundles at the dermal-epidermal junction, adjacent to the MM lesion.\nCollagen fiber density was quantified from seven regions using ImageJ image analysis software (Freeware, rsbweb.nih.gov) to calculate the percentage area of collagen fibers for that region. The images were segmented using an adaptive threshold algorithm with a fixed kernel size and offset for all samples. Data was expressed as Area %, calculated using area of collagen fibers/ area of measuring frame x 100. Generally SHG produces very high contrast images with very low or no background and since pump laser beam polarization was circular, segmentation based on threshold values proved to be a robust method. The regions quantified are highlighted in Fig. 2A and were an area of non-lesion skin under the dermal-epidermal junction (labeled A), the lateral melanoma border under dermal-epidermal junction (labeled B), an area under the middle part of the lesion and under the dermal-epidermal junction (labeled C), the areas labeled D, E, F, are all below C but one field vertically deeper to each other, and the area of dermis at the same depth as F but away from the lesion (labeled G in Fig. 2A).\nFresh pieces of whole rat and human skin were cleared of subcutaneous fat and connective tissue, and hair in the case of the rat samples, and mounted onto glass slides in PBS buffer. Human skin samples were collected from The Royal London Hospital Trust, department of surgery with full patient consent and ethical approval, and imaged within four hours. One sample was from 22 year old, breast reduction patient, and the other three samples were breast reconstructions from age rages of 30–45 years. Two samples appeared heavily pigmented whilst the other two appeared very lightly pigmented. SHG image acquisition was performed in both backscattered and forward propagated (transmission) geometries from the epithelial surface and imaged at full depth (deep into the dermis) in order to demonstrate that the technique is transferable to intact live skin. A Leica 20x 0.7 NA, long working distance objective, was used for image acquisition. A single field of 512 x 512 pixels (750 x 750 µm or 430 x 430 µm) at zoom 1.0 or 1.7 at 800 Hz with 2.5µm z-step, an imaging average of 2 frames was acquired for both rat and human ex vivo samples. Typical imaging times for ex vivo skin samples were 0.7 s per frame and up to 225 z-slices per sample; therefore total-imaging times did not exceed 3 min. 3D-images were generated with Imaris visualization software (Bitplane Scientific Software. Zurich, Switzerland).\nThree images were obtained for each unstained melanoma section; an SHG image in the forward propagated (Fig. 1A ) and backscattered geometries (Fig. 1B), followed by a bright field image (Fig. 1C). Bright field and SHG images superimposed gave an image of collagen distribution within the bright field background for each section (Fig. 1D).\nThe SHG collagen signal showed a rapid transition at the two lateral melanoma borders, from very low or no SHG signal to that of normal collagen distribution found in non-lesion areas of skin. Medial to the melanoma borders there was a dramatic reduction in collagen SHG signal making the identification of the lateral boarders of cancer invasion unambiguous (Fig. 1D, 2A, 3C and 4B ).\nQuantification of collagen fiber density from different regions around the MM lesion showed varying degrees of fiber density, expressed as Area %, ranging from 0.8% in the region labeled (C) (Fig. 2A) in the middle of the MM lesion, to 38% per unit area, in non-lesion area of skin labeled (A and G) (Figs. 2A and B). In regions labeled (D, E and F) there was a gradual increase of collagen fiber density from 9.1% to 19.88% to 33.2%, respectively (Figs. 2A and B). This increase correlated with increasing distance from the MM lesion towards a more ‘normal’ collagen fiber density. Each microscopic field (one tile in the montage) is equivalent to 375µm; therefore the collagen fiber density goes from almost zero in region C to 33.2% in region F, a distance of 1500µm (Figs. 2A-B). In the non-diseased areas of all skin sections we found a normal distribution of collagen up to the dermo-epidermal junction. Linear regression of collagen fiber density from region C (minimum SHG signal) to region G (maximum SHG signal in non-diseased area) showed an R2 value of 0.9849 suggesting that collagen fiber density is a good biomarker for malignancy (Fig. 2B).\nAssessment of the lateral melanoma borders derived from SHG images versus H&E images (Fig. 3A) by the histopathologist were found, on direct observation, to co-localize in almost exactly the same positions (Fig. 3C). Cross-reference control comparison showed that melanoma borders obtained from H&E and Melan-A stained sister sections were also well co-localized (Figs. 3A and B, Figs. 4A and B).\nNon-parametric statistical analysis using Mann-Whitney U-Test revealed no significant difference between the lateral melanoma borders as determined by an independent histopathologist using H&E sections and those assessed by an independent scientist using the SHG images of the corresponding unstained sister section (Fig. 5A ). p-values for the right lateral border comparison was p = 0.9491 representing a mean difference of 0.85 mm ± 0.18 mm (SE) (n = 7) and for the left border p = 0.9164 representing a mean difference of 0.55 mm ± 0.13 mm (SE) (n = 8), respectively (Fig. 5B). The total p-value for both sides was p = 0.9339. Kendall-Rank Correlation Analysis revealed a highly significant correlation between the lateral melanoma borders derived from histopathologists assessment and those from SHG images. p-value for the right lateral border comparison was p = 0.0069 (n = 7) and for the left side p = 0.0260. (n = 8) The tied p-values for the right and left sides were p = 0.0056 and p = 0.0260, respectively. The total p-value for both sides correlation analysis was p = 0.0012 (Fig. 5B).\nSHG imaging of whole, ex vivo rat (Fig. 6A ) and human skin (Fig. 6 B) samples yielded detailed images of collagen morphology through the entire thickness when imaged from the epidermis, in both backscattered and transmission geometries. In the case of rat skin, SHG transmission images were detected through the whole thickness of the skin, although only the upper 150 µm is shown in (Fig. 6A). The blue channel is the two-photon auto fluorescence image of the upper epidermis, whilst the red and green channels are the transmitted and back-scattered SHG signals, respectively. In the lightly pigmented human skin samples, we were able to image through the whole thickness of epidermis and dermis to depths of approximately 300µm in the back-scattered geometry (green signal) and over 1000µm in the transmission geometry (red signal) (Fig. 6B). The heavily pigmented human samples could not be imaged from the epidermal surface, presumably because of the absorption of the 880nm wavelength light by melanin. However, if the samples were imaged from the dermal surface, clear SHG images of collagen were detected in both forward and back-scattered geometries (images not shown). Scale bars = 50 µm for each orthogonal plane.\nThese data support our hypothesis in that there are no significant differences between the two methods of identifying the borders of the MM lesions. Furthermore, it also emphases the fact that the extent of MM lesion can be asymmetrical and hence using Breslow thickness alone to empirically define a radius from the center of the MM lesion can in many cases be insufficient. This effect can be compounded in cases where there is very irregular shaped, MM lesions and would lead to more than one attempt to surgically remove the tumor.\nWe have demonstrated that SHG microscopy is a rapid and reliable method for the clinical management of MM by defining the borders of the lesions and the extent of dermal invasion (Breslow thickness) based on collagen morphology and density. Our results show that we can accurately define the lateral borders in histological sections of MM biopsies, which correlate significantly with the current gold standard assessments (H&E and Mealn A). This study provides initial evidence that collagen density in and around the suspected MM lesion may possibly be used as a biomarker for skin cancer diagnostics; further studies are in progress to confirm if collagen density and or architecture can differentiate a MM from a squamous cell or basal cell carcinoma as well as other skin tumors. Therefore, the in vivo applicability and identification of skin tumors using SHG microscopy is at present independent of lesion type so clear identification/confirmation is still required. The scant data in the literature about collagen fiber density around MM and NMSC lesions’ warrants more detailed studies but until then current diagnostic practices will still require immunophenotyping. In the diseased areas we observed a gradual decline in collagen density. This was most dramatic in the areas directly under the melanoma, which showed the weakest SHG signal; in most cases there was a complete absence of SHG signal due to the destruction of collagen by MMP’s produced by the malignant melanocytes. In the MM lesion areas the collagen morphology was greatly affected and was present in very short, thin ‘wispy’ fibers. The SHG signal then intensified with increasing depth below the lesion, until the collagen took on a more normal appearance. Furthermore, we have demonstrated that SHG imaging can detect collagen in freshly excised human and rat skin samples in both the back-scattered and transmission geometries; up to 300 µm and 1mm, respectively.\nSHG imaging has been used to detect collagen non-invasively in many tissues including human skin [27,28]. It is a non-absorptive, non-linear, two-photon optical effect that can detect non-centrosymmetric crystalline structures such as collagen type I and III in unstained, live and fixed tissues [27,28]. It typically employs infrared or longer wavelength pulsed lasers, enabling good depth penetration and very little or no phototoxicity to tissues. Furthermore, the non-absorptive nature of the technique results in conservation of energy and therefore little or no heat is dissipated into non-pigmented tissue from the laser source, which would otherwise damage or even destroy live tissues.\nUntil social attitudes to skin cancer prevention are changed, early detection and treatment is the key to reducing mortality rates. Therefore the major challenge for skin cancer diagnostics is the early detection of non-metastasized malignant lesions and to reliably differentiate these from the less life threatening malignant cancers such as SCC, BCC and benign nevi BN, at the time the patient presents to the clinician. The most significant risk to life is MM and early detection and excision is crucial if the chances of survival are to be maximized [29,30]. SCC and BCC represent a much lower risk to life expectancy and are highly treatable if the correct diagnosis is made early on in the disease [29,30]. BN present little or no risk to patient survival; however, accurate diagnosis is required, as these can often resemble MM lesions. In addition, an apparently BN may become dysplastic and progress to a MM.\nOne of the key features of all skin cancers is the remodeling of extracellular matrix by MMP’s, principally collagen type I and III, which is clearly seen to be disrupted along the borders of the invading cancer cells  and missing in the diseased tissue itself. However, current diagnostic procedures do not include assessment of collagen density/architecture as a parameter, even though this is a key event in skin cancer progression and can potentially be used as a biomarker. We propose that collagen architecture, and its presence or absence can be used as, 1) a reliable marker of MM invasion through tissues, and 2) that it can be used to accurately define melanoma invasion borders.\nA number of non-invasive and experimental imaging techniques are currently being used in dermatology clinics throughout the world including the Dermatascope [32,33] and single- or two-photon epifluorescence confocal microscope based systems . However, anecdotal reports and clinical interpretations of these techniques have been varied, with a tendency towards over diagnosing non-malignant conditions such as SCC and BCC putting them incorrectly into the MM category [32,33]. This leads to unnecessary surgery, pain and psychological stress for patents, believing that they have a MM, and ultimately, leads to increased costs to the Health Services. More importantly however, is the reliability and accuracy in misdiagnosis of a MM where current, non-histological methods, have a maximum of 87% specificity rate compared to CLSM of 98% .\nThe data from this study clearly shows that there can be very significant differences in the distance from the center of the tumor to the left and right hand borders of irregular shaped MM lesions; In Fig. 5A, sample numbers 3 and 6, show an approximately 50% differences in left- and right-hand borders, illustrating that the tumors in these samples were asymmetric. If this asymmetry were significant then clinical management of MM based on Breslow thickness measurements would not be sufficient in determining how much tissue to excise from the center of the tumor so as to encompass all the borders. The current practice can lead to multiple excision biopsies being performed, and in some cases, putting the patient at increased risk of tumor metastasis. Therefore, present-day methods for skin cancer diagnostics are complicated by the lack of a reliable non-invasive assessment technique that could eliminate the excision biopsy stage of the assessment if it is found to be non-malignant. A recent study suggests that collagen SHG signature is a promising marker for MM diagnosis  and this study supports that notion.\nAny future diagnostic instrument will depend on the ability to image through the surface of the skin and thus the back-scattered signal is more important in this respect. Selecting the appropriate wavelength to ensure adequate depth penetration and to overcome absorption of the light by melanin will be crucial to the success of any such instrument. We found that at 880nm we could not detect an SHG signal from heavily pigmented human skin samples from the epidermal surface, but was able to when imaged from the dermal surface. This result emphasizes the need to fully assess the tissue wavelength absorbance characteristics so that SHG imaging can be performed in pigmented as well as non-pigmented samples. Other groups have shown, with custom built microscopes that longer infra-red wavelengths (1200 −1300 nm) can overcome the absorbance of shorter infra-red wavelength (880 nm) we have used in this study . However, in lightly pigmented skin the areas immediately outside of a suspected cancerous lesion would still be penetrable by 880nm light, although longer wavelengths would be more appropriate. Our research is aimed at developing a low resolution, fiber optic, handheld device that can give rapid and reliable assessment of collagen presence/absence outlining the MM lesion, in the first instance, and then a high resolution lens-based system for differentiating between, MM, SCC, BCC and BN based on collagen architecture and density. It is important to note that the low resolution system needs only to penetrate the skin to just below the dermal-epidermal border as this will detect the presence (presumptive normal, non-diseased tissue) or absence (presumptive MM lesion) of the collagen SHG signal The clear and unequivocal data from this study provide good evidence that SHG imaging can be a viable alternative to the existing diagnostic procedures.\nIn conclusion, this study provides good evidence that SHG imaging has the potential to improve on the current excision biopsy stages of MM diagnosis with a single assessment at first presentation of the patient. This can potentially shorten the diagnostic process and by demarcating the boundaries accurately ensure that the entire MM is removed first time thereby saving lives.\nThe authors would like to thank Mr. R Ragoowansi and Mr. G Moir Constaltant Plastic Surgeons of Department of Plastic Surgery, St Barts and the London NHS Trust (London, UK) for the their help and supply of the normal human skin samples. Thanks also goes to Dr Sian Hughes, Consultant Histopathologist and Dr. Lorette Folkes Special Registrar, Department of Histopathology, University College Hospital, London, UK for their help in independently confirming MM diagnosis and indicating the borders of the MM lesions on the normal H&E and Melan-A samples. Thanks to Mr. Kieran Power MRCP, for the independent assessment of MM boarders using the SHG images. This work was supported by Proof of Concept Funding Grant from UCL Business (UCL, London, UK). All authors have no conflicts of interest to declare.\nReferences and links\n1. Cancer Research UK, “Statistical Information Team” (2010), http://info.cancerresearchuk.org/cancerstats/types/skin/incidence/.\n2. ISD-Online, “Cancer incidence and mortality data” (2010), www.isdscotland.org/isd/183.html.\n3. Northern Ireland Cancer Registry, “Cancer incidence and mortality” (2008), www.qub.ac.uk/research-centres/nicr/Data/OnlineStatistics/MalignantMelanoma/.\n4. Office for National Statistics, “Registrations of cancer diagnosed in 2005, England” (2008), www.statistics.gov.uk/statbase/Product.asp?vlnk=8843&More=N.\n5. Welsh Cancer Intelligence and Surveillance Unit, “Cancer incidence in Wales, 2003-2007” (2010), www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=35385.\n8. P. Eves, E. Katerinaki, C. Simpson, C. Layton, R. Dawson, G. Evans, and S. Mac Neil, “Melanoma invasion in reconstructed human skin is influenced by skin cells--investigation of the role of proteolytic enzymes,” Clin. Exp. Metastasis 20(8), 685–700 (2003). [CrossRef] [PubMed]\n9. N. Monhian, B. S. Jewett, S. R. Baker, and J. Varani, “Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients,” Arch. Facial Plast. Surg. 7(4), 238–243 (2005). [CrossRef] [PubMed]\n10. C. Ntayi, W. Hornebeck, and P. Bernard, “Influence of cultured dermal fibroblasts on human melanoma cell proliferation, matrix metalloproteinase-2 (MMP-2) expression and invasion in vitro,” Arch. Dermatol. Res. 295(6), 236–241 (2003). [CrossRef] [PubMed]\n11. J. Varani, Y. Hattori, Y. Chi, T. Schmidt, P. Perone, M. E. Zeigler, D. J. Fader, and T. M. Johnson, “Collagenolytic and gelatinolytic matrix metalloproteinases and their inhibitors in basal cell carcinoma of skin: comparison with normal skin,” Br. J. Cancer 82(3), 657–665 (2000). [CrossRef] [PubMed]\n12. F. Wach, A. M. Eyrich, T. Wustrow, T. Krieg, and R. Hein, “Comparison of migration and invasiveness of epithelial tumor and melanoma cells in vitro,” J. Dermatol. Sci. 12(2), 118–126 (1996). [CrossRef] [PubMed]\n13. E. Wandel, A. Raschke, G. Hildebrandt, J. Eberle, R. Dummer, U. Anderegg, and A. Saalbach, “Fibroblasts enhance the invasive capacity of melanoma cells in vitro,” Arch. Dermatol. Res. 293(12), 601–608 (2002). [CrossRef] [PubMed]\n16. J. Paoli, M. Smedh, and M. B. Ericson, “Multiphoton laser scanning microscopy--a novel diagnostic method for superficial skin cancers,” Semin. Cutan. Med. Surg. 28(3), 190–195 (2009). [CrossRef] [PubMed]\n17. M. H. Lien and V. K. Sondak, “Diagnostic techniques for primary cutaneous melanoma,” G. Ital. Dermatol. Venereol. 144(2), 187–194 (2009). [PubMed]\n19. T. A. Theodossiou, C. Thrasivoulou, C. Ekwobi, and D. L. Becker, “Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections,” Biophys. J. 91(12), 4665–4677 (2006). [CrossRef] [PubMed]\n20. C. J. R. Sheppard, J. N. Gannaway, R. Kompfner, and D. Walsh, “The scanning harmonic optical microscope,” IEEE J. Quantum Electron. 13(9), 912 (1977). [CrossRef]\n21. S. Roth and I. Freund, “Second harmonic-generation in collagen,” J. Chem. Phys. 70(4), 1637–1643 (1979). [CrossRef]\n22. P. P. Provenzano, K. W. Eliceiri, and P. J. Keely, “Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment,” Clin. Exp. Metastasis 26(4), 357–370 (2009). [CrossRef] [PubMed]\n23. A. Gerger, S. Koller, T. Kern, C. Massone, K. Steiger, E. Richtig, H. Kerl, and J. Smolle, “Diagnostic applicability of in vivo confocal laser scanning microscopy in melanocytic skin tumors,” J. Invest. Dermatol. 124(3), 493–498 (2005). [CrossRef] [PubMed]\n24. G. Cox, E. Kable, A. Jones, I. Fraser, F. Manconi, and M. D. Gorrell, “3-dimensional imaging of collagen using second harmonic generation,” J. Struct. Biol. 141(1), 53–62 (2003). [CrossRef] [PubMed]\n27. E. Brown, T. McKee, E. diTomaso, A. Pluen, B. Seed, Y. Boucher, and R. K. Jain, “Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation,” Nat. Med. 9(6), 796–801 (2003). [CrossRef] [PubMed]\n32. V. de Giorgi, D. Massi, C. Salvini, S. Sestini, and P. Carli, “Features of regression in dermoscopic diagnosis: a confounding factor? Two clinical, dermoscopic-pathologic case studies,” Dermatol. Surg. 32(2), 282–286 (2006). [CrossRef] [PubMed]\n35. T. Hompland, A. Erikson, M. Lindgren, T. Lindmo, and C. de Lange Davies, “Second-harmonic generation in collagen as a potential cancer diagnostic parameter,” J. Biomed. Opt. 13(5), 054050 (2008). [CrossRef] [PubMed]", "label": "Yes"}
{"text": "Leucorrhoea or (leucorrhoea British English) is a thick, whitish or yellowish vaginal discharge. There are numerous reasons for leucorrhoea, the standard one being estrogen imbalance.\n[Citation needed] The measure of release may increment because of vaginal disease or STDs, and it might vanish and return every now and then. This release can continue happening for quite a long time, in which case it turns out to be more yellow and putrid.\nIt is normally a non-neurotic indication auxiliary to provocative states of vagina or cervix.\nIt's anything but a noteworthy issue yet is to be settled as quickly as time permits.\nIt tends to be a characteristic resistance instrument that the vagina uses to keep up its synthetic parity, and in addition to save the adaptability of the vaginal tissue.\nThe expression \"physiologic leucorrhoea” is utilized to allude to leucorrhoea because of estrogen stimulation.\nLeucorrhoea may happen regularly amid pregnancy.\nThis is caused by expanded blood flow to the vagina because of expanded estrogen. Female newborn children may have leucorrhoea for a brief timeframe after birth due to their in-uterine introduction to estrogen.\nLeucorrhoea can likewise be caused by sexual stimulation.\nIt might likewise result from irritation or clog of the vaginal mucosa. In situations where it is yellowish or emits a smell, a specialist ought to be counseled since it could be an indication of a few ailment forms, including a natural bacterial disease (oxygen consuming vaginitis) or STD.\nThere are various reasons why this stream may end up over the top. These include:\nContaminations: The vagina is exceptionally helpless to contagious, bacterial and parasitic diseases. These diseases can be advanced by poor cleanliness, the utilization of engineered clothing and unprotected sex. An expansion in vaginal release is normally one of the primary indications of a vaginal disease.\nDamage: Giving birth to a kid, having a fetus removal or inordinate sex may bother the covering of the vagina and cause damage. This thusly can trigger leucorrhea.\nIllnesses: Diseases, for example, diabetes or paleness may debilitate the resistant framework and trigger vaginal contaminations causing an exorbitant release. An UTI (Urinary Tract Infection) or worms in the stomach may likewise spread disease to the vagina.\nContraceptives: Contraceptive showers and jams utilized amid intercourse can chafe the vagina and cause over the top releasing. Now and again, aggravation of an intra-uterine prophylactic gadget can likewise cause release and agony.\nAwful cleanliness: Not changing your clothing frequently enough, neglecting to change tampons or sharing open toilets can likewise increment vaginal release.\nLeucorrhea can be forestalled by keeping the genital region spotless and dry, wearing cotton clothing, maintaining a strategic distance from the utilization of beauty care products on the genital zone and having safe intercourse.\nDrinking a lot of water will likewise help flush poisons from the body and control the stream of vaginal release.\nWhenever left untreated, this condition can spread to the uterus, fallopian cylinders and cervix and can trigger pelvic incendiary illness.\nOn account of post-menopausal ladies over the top vaginal release can likewise be viewed as a side effect of cervical malignancy and henceforth should be broke down as quickly as time permits.\nIn any case, this condition can be effectively treated at home.\nAbstain from eating sugar, hot and zesty nourishment and liquor to treat release.\nEating curd can likewise help regard vaginal release as it contains lactic corrosive that cools the body. Likewise, dodge anxiety as this can build the release.", "label": "Yes"}
{"text": "Size: 498 KB\nSearch tags: Bacterial growth curve pdf\nkeh bf jcu cz doc\n3c. Catalase test on the selected colony 9a. Determination and counting colonies cfu 10a. Determination and counting colonies cfu 11. Growth curve of pure bacterial strain E. coli.\nEbookbrowse is a search engine of ebooks on the Internet and does not upload or store any files on its server.", "label": "Yes"}
{"text": "Understanding Ozempic, Weight Loss, and Cancer Risk\n- Stand-up comedian Tracy Morgan, 55, who has overcome a traumatic brain injury, has admitted to gaining weight while taking the blockbuster weight loss drug Ozempic, a brand name of Novo Nordisk’s semaglutide.\n- The resilient actor said he learned to “out-eat” Ozempic, which is administered as a weekly injection, assists the body by helping the pancreas make more insulin, ultimately lowering blood sugar levels. Although it has not been FDA-approved for weight loss, the drug has been prescribed by some doctors\n- Ozempic, the brand name of Novo Nordisk’s semaglutide, a highly popular drug also known under the brand names Rybelsu and Wegovy, is an FDA-approved prescription medication for adults with type 2 diabetes. The drug, which is administered as a weekly injection, assists the body by helping the pancreas make more insulin, ultimately lowering blood sugar levels. Although it has not been FDA-approved for weight loss, the drug has been prescribed by some doctors.\n- If you’re considering taking a weight loss drug, talk with your care team about whether that’s a good option for you. And make sure you consider good diet and exercise practices as a part of your treatment plan.\n- Being overweight or obese is clearly linked to an overall increased risk of cancer, according to the American Cancer Society. One of our experts say “losing weight is a great way to reduce one’s risk” for cancers.\n- It’s also important to know that conditions caused or exasperated by obesity like diabetes and heart disease can pose problems for people who’ve already been diagnosed with cancer.\nMost people who take drugs like Ozempic, an FDA-approved prescription medication for adults with type 2 diabetes, have reported significant weight loss, but in Morgan’s case, he revealed in a recent interview he’s learned to “out-eat” Ozempic.Read More\nDuring Morgan’s appearance this week on “The Tonight Show Starring Jimmy Fallon,” the beloved comedian revealed he’s actually gained weight while taking Ozempic, following a compliment from Fallon, who said, “You look good, bud. You look great. How you staying in shape these days?”View this post on Instagram\nMorgan replied saying, “Thank you, baby. … Well, that’s Ozempic. Yeah … but I’ve learned to out-eat Ozempic. I out-ate Ozempic.\n“I’ve gained 40 pounds.”\nWhen Fallon said he’s “never heard of anyone gaining 40” pounds, Morgan jokingly replied, “I’m like Magic Johnson. I gained 40 pounds.”\nIt’s unclear if Morgan is still taking the drug, however, he previously opened up about taking the blockbuster weight loss drug with Hoda Kotb and Jenna Bush Hager, the co-hosts of “TODAY.”\nLast August, admitted to taking Ozempic “cuts my appetite in half,” humorously adding, “Now I only eat half a bag of Doritos.”\nWhen asked how he’s been able to stay in shape, he explained, “That’s Ozempic. That’s how this weight got lost… I went and got a prescription and I got Ozempic.”\nHowever, Morgan also noted that he has a strict workout regime, where he gets up at 7 am every day and goes to the gym at 10am, adding, “Then I go back to sleep and that’s my life.”\nTracy Morgan also shares his hot takes on some topics, from tattooing your partner's name to going to space. pic.twitter.com/aTWdpcxfwy\n— TODAY with Hoda & Jenna (@HodaAndJenna) August 14, 2023\nMorgan, who is also known for playing Tracy Jordan on “30 Rock,” has surely come a long way since recovering from a traumatic brain injury after being involved in a serious vehicle accident back in 2014.\nThe accident occurred when Morgan was riding in a limousine with some of his buddies in New Jersey when they were struck by a Wal-Mart truck, an event which led to the death of his friend Jimmy McNair and Morgan suffering a broken femur, broken ribs, broken bones in his face, and in an eight-day long coma, according to Isaacs & Isaacs Personal Injury Lawyers.\nAfter waking from his coma, it took Morgan a week to get back his eye sight and he had been suffering from a brain injury.\nIn the wake of the accident, his lawyer Benedict Morelli made the following statement to the Associated Press, “When you have a traumatic brain injury, it takes a very long time to find out how you’re going to do and how much you’re going to recover.\n“You just don’t know. He’s still fighting and trying to live his life at the same time and trying to get better, and he’s just not better. We’re hoping and praying to get him back to where he was.”\nMorgan appears to be doing incredible well years later, and it’s possible that Ozempic has helped him maintain his overall health.\nAs per UC Davis Health, when it comes to weight loss, “Ozempic works by mimicking a naturally occurring hormone. As those hormone levels rise, the molecules go to your brain, telling it you’re full. It also slows digestion by increasing the time it takes for food to leave the body. This is similar to the effect of bariatric surgery.\n“When using Ozempic to treat diabetes, weight loss is a common side effect. It is designed to be taken long-term.”\nExpert Resources On Healthy Living\n- SurvivorNetTV Presents ‘How Not To Get Cancer: Diet’ — The Power of Prevention & Healthy Habits\n- 8 Secrets to a Long, Healthy Life: Jacques Houot and the Fountain of Youth\n- Exercise and ‘Chemo Brain’: Can Physical Activity Save Breast Cancer Patients from Brain Fog During Chemotherapy?\n- What to Know About Diet and Exercise if You Have Cancer\n- Facing Cancer: How to Turn Stress into Strength\nThe academic health center, further explains, “Ozempic is not approved for weight loss. However, semaglutide is approved for weight loss under the name Wegovy. Ozempic has a smaller dose of semaglutide than Wegovy.\n“Ozempic and Wegovy are made by the same company. They both contain the same active ingredient semaglutide. However, Wegovy contains higher doses of it and is designed for weight loss. Ozempic has lower doses of semaglutide and was developed specifically for type 2 diabetes patients.”\nUC Davis Health also notes that Ozempic is usually covered by health insurance and Wegovy is often not.\nHealth Risks Associated With Ozempic\nAlthough people have had success with weight loss thanks to Ozempic, which is the brand name of the drug Semaglutide, it’s important to understand there are dangers associated with the drug. Healthcare company Lexicomp recently revealed there are negative side effects of the medication, including an increased risk of cancer.\nLexicomp explains Ozempic as “an injectable prescription medicine for adults with type 2 diabetes mellitus that: along with diet and exercise may improve blood sugar (glucose),” noting it’s not the first choice of medicine for treating diabetes.\nAs for the most important information people should know before taking the drug, Lexicomp says Ozempic may cause serious side effects. Some of the possible side effects include:\n- inflammation of your pancreas (pancreatitis)\n- changes in vision\n- low blood sugar, kidney problems\n- kidney failure\n- serious allergic reactions.\n“The most common side effects of OZEMPIC may include nausea, vomiting, diarrhea, stomach (abdominal) pain and constipation. Talk to your healthcare provider about any side effect that bothers you or does not go away,” Lexicomp states. “These are not all the possible side effects of OZEMPIC. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.”\nThe Memorial Sloan Kettering Cancer Center also says, regarding Lexicomp’s warning, “This drug has been shown to cause thyroid cancer in some animals. It is not known if this happens in humans.\n“If thyroid cancer happens, it may be deadly if not found and treated early. Call your doctor right away if you have a neck mass, trouble breathing, trouble swallowing, or have hoarseness that will not go away. Do not use this drug if you have a health problem called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you or a family member have had thyroid cancer.”\nThe side effects that call for immediate medical attention, in regard to all uses of the drug, the MSKCC lists as:\n- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.\n- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.\n- Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; change in stools; dark urine or yellow skin or eyes; or fever with chills.\n- Severe dizziness or passing out.\n- A fast heartbeat.\n- Change in eyesight.\n- Low blood sugar can happen. The chance may be raised when this drug is used with other drugs for diabetes. Signs may be dizziness, headache, feeling sleepy or weak, shaking, fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do for low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.\nSevere and sometimes deadly pancreas problems (pancreatitis) have happened with this drug. Call your doctor right away if you have severe stomach pain, severe back pain, or severe upset stomach or throwing up.\nFor anyone using the drug for weight loss, they should speak with their doctor if they notice “new or worse behavior or mood changes like depression or thoughts of suicide.”\nHow Does Semaglutide Work?\nIntegral to blood sugar control, GLP-1 is a hormone released by the gut in response to food. It causes the pancreas to release insulin. A rising blood insulin level causes all the body tissues to start absorbing glucose (blood sugar) from the bloodstream, thereby lowering blood glucose levels. GLP-1 also prevents the release of glucagon, which is a hormone that raises blood sugar levels by stimulating liver cells to release glucose and helps people feel full for longer. These effects can also cause people to lose weight.\nModern studies on GLP-1 have shown that it has a role beyond glucose control. It modulates the immune system cells, including NK cells, in a way necessary for weight loss.\nSemaglutide is a GLP-1 receptor agonist, meaning that it mimics the effects of GLP-1 in the body. Given as weekly subcutaneous injections It is normally prescribed to manage blood glucose levels in diabetic patients. It also leads to a significant amount of weight loss in these patients.\nAlthough semaglutide has been approved for blood sugar control in people with type II diabetes, under the brand name Ozempic, and for weight loss under the brand name Wegovy, it has not been approved for use as an immune booster and cancer preventative. Thus, it should not be prescribed for that purpose. Those taking it to control their diabetes or weight, however, can expect the additional benefit of improving their immunity. as per a recent study, and lowering their cancer risk, as a link between weight and cancer does exist.\nWeight and Cancer Risk\nBeing overweight or obese is clearly linked to an overall increased risk of cancer, according to the American Cancer Society. And in a 2022 study out of Brigham and Women’s Hospital, Boston, researchers found that childhood obesity may lead to an early cancer diagnosis.\nIn an earlier interview with SurvivorNet, Dr. Andrea Tufano-Sugarman of NYU Langone Health talked about the importance of maintaining a healthy weight, saying, “While all cancers cannot be prevented, losing weight is a great way to reduce one’s risk.”\nDr. Stephen Freedland of Cedars Sinai Medical Center also notes that obesity can affect a person’s prostate cancer risk and prognosis.\n“Some of the best data we have is that obesity increases the risk of not just getting prostate cancer, but actually dying from prostate cancer,” Dr. Freeland previously told SurvivorNet.\n“Obese men are 35 percent more likely to die from prostate cancer.”\nBeing overweight or obese is clearly linked with an increased risk of many types of cancer including the following:\n- Breast cancer (in women past menopause)\n- Colon and rectal cancer\n- Endometrial cancer (cancer of the lining of the uterus)\n- Esophagus cancer\n- Gallbladder cancer\n- Kidney cancer\n- Liver cancer\n- Ovarian cancer\n- Pancreas cancer\n- Stomach cancer\n- Thyroid cancer\n- Multiple myeloma\n- Meningioma (a tumor of the lining of the brain and spinal cord)\nBeing overweight or obese might also raise the risk of other cancers such as:\n- Non-Hodgkin lymphoma\n- Male breast cancer\n- Cancers of the mouth, throat, and voice box\n- Aggressive forms of prostate cancer\nIt’s also important to know that conditions caused or exasperated by obesity like diabetes and heart disease can pose problems for people who’ve already been diagnosed with cancer. They can lead to treatment complications, prevent people from receiving the recommended first-line therapies and even increase the risk of undergoing surgery. Overweight patients might not even have the option of surgery since removing the cancer could pose potential complications that could outweigh the benefits.\nDr. Sairah Ahmed, associate professor in the division of cancer medicine at the University of Texas MD Anderson Cancer Center, previously said focusing on diet and exercise in a healthy way can help a person with cancer feel like they have more control.\n“Diet, exercise and stress control are extremely important when going through cancer therapy, as well as once you’re done treating your cancer and trying to get back to the rest of your life,” she said.\nDr. Ahmed wants to remind people that none of the gimmicky diets are helpful for cancer-fighting. She says the main goal should be to simply consume nutritious foods.\n“I’m asked about keto diets, alkaline diets, no-sugar diets,” she said. “Often I will tell patients there is not any one diet that has a better potential to keep their cancer away. There’s no data that shows that any of those help to treat cancer any better.\n“You want to have a moderate diet where you’re including lots of fruits and vegetables, but you’re still eating fat and protein, and you want to maintain physical exercise,” she said.\nDr. Ken Miller, the director of outpatient oncology at the University of Maryland Greenebaum Cancer Center, recommends these four things for cancer survivors to do to try and avoid another cancer diagnosis:\n- Exercise at least two hours a week, walking counts\n- Eat a low-fat diet\n- Eat a colorful diet with lots of fruits and vegetables, doctors recommend two to three cups a day\n- Maintain a healthy weight\nContributing: SurvivorNet Staff", "label": "Yes"}
{"text": "The history of zinnias, named for Dr. Johann Gottfried Zinn, goes back several hundred years to 18th century Europe. Thanks so much! * Zinnia angustifolia (Z. linearis). The use of excessive fertilizer could cause salt burns to the plant. I'd still like understand the problem. The biggest difference between the two is that too little water will result in your plant's leaves feeling dry and crispy to the touch while too much water results in soft and limp leaves. The center of an older spot may drop out leaving a ragg ed hole. The leaf has completed the life cycle of absorbing solar radiation and producing plant energy and will naturally senesce = die; 2. Mums are a vigorous late-blooming garden plant with showy flowers that turn brown if weather conditions become adverse. L ater, th e lesions become fairly large (up to 10 mm in diameter), irregular, dark reddish brown or purple, and dry (Figure 1). After checking the link on leaf spot you included and my zinnias, I didn't see any brown/yellow spots, just holes. It may be as simple as cutting down on your watering habits, but other causes may be a little more complex. Droopy leaves and stems. Zinnias are prone to two leaf diseases in the Northeast: powdery mildew and leaf spot fungus. Answered by Downtoearthdigs on September 11, 2018 Do you grow your zinnias mainly for cutting flowers? Zinnias are … Not Enough Water. It tends to only affect the leaves, not the stems or blooms. Pinterest. Spider plants, tropical plants, and those with long, strappy leaves are especially susceptible.The main difficulty when confronting leaf-tip burn is to remember that it's a symptom of a larger problem (usually a cultural issue) as opposed to a condition in itself. Right before the leaves fall off the plant, they will turn yellow. This conserves water. Why Are My Plant Leaves Turning Yellow? Alternaria is a fungal leaf spot that produces lesions start out as small dark spots (Fig. The pests feed by puncturing plants and sucking out the sap inside, creating the streaks. Cause: Overwatering plants actually drowns them by depriving the roots of air. Water and fertilizer are key to growing healthy and attractive hanging baskets. PM does that. Email. Cheryl, my phlox get those brown leaves too. This also occurs when plants have too much water. Hope your zinnias perk up soon! What could have caused this? In a sense, you can consider browning leave a precursor to wilted leaves. Since then the bottom leaves are turning really crisp and just fall apart if you touch them. Some people make the mistake of applying too much fertilizer, so if you notice the flowers turning brown, or the leaves turning yellow, it’s a clear sign that you are adding too much fertilizer in the mix. WhatsApp. Our zinnias have brown spots on the leaves and I am wondering if there is anything I can do to prevent this. To the naked eye, they look like tiny threads. I don't know the name of the plant and I had put it outdoors.The plant is exposed to full sun for 6-7 hours. Great Idea to Cut Off Brown Tips on Daffodil Leaves. Good luck! Two weeks ago, I bought this outdoor flower plant to brighten up my herb garden. My large yellow African marigolds bloomed like crazy until early August. Affected leaves eventually turn yellow, then brown. A few days ago I kept them outside when it was nice and warm around 18 to 20 degrees celsius. have several baskets of wave petunias. And while there are many reasons for plain old brown spots, when those spots look like little brown bull’s-eyes, the answer my friends is fairly simple, organism-wise that is. When the roots don't get air, the leaves hang down and the stems droop. They have grown quite tall. Previous article 9 Easy to Grow Vegetables for First Time Gardeners. I have a garden full of zinnias that have developed yellow spots on the leaves. Hi I have grown some Polar Bear and Candy Cane Zinnias indoors for last few weeks. Sadly, the leaves look like they are dying. Leaf-tip browning is an annoying condition that commonly affects certain types of houseplants. One great idea leads to another!! Attached are 2 closeups of affected zinnia leaves. 2. You can cut out the nasty-looking parts and add the bits and pieces to fresh salads. Any sharp, sturdy pair of scissors will do, but the shape and strength of kitchen shears make them a great choice for this job. They did wonderfully well all summer long. From indoor and outdoor gardeners alike, one of the most common gardening questions is, “Why do my plants have spotted and brown leaves?”. Facebook. Lesson learned -- I definitely won't plant zinnias in this spot next year. Severely affected leaves brown, dry, and become brittle. Check often to see if your leaves and fans are turning brown or yellow and falling over. In this post, I will talk about 6 different reasons why your plant leaf edges are turning brown and crispy! Courtney (Click Images To View Larger Versions) You are correct - those little white wonders are spiders, but they are not the cause of the spots on the zinnia leaves. Some of my phlox this year have almost the whole stalk either bare, because they fell off, or almost all bare with just brown leaves left. If the tip of the leaf is turning brown this is a sign of over watering. THRIPS. Very sharp blades minimize damage to the plant's cells, which reduces the amount of energy it must expend healing the wound. When mum blooms are finished flowering, the individual blossoms naturally turn brown and fall off. Thanks Kristena! Little kids love to cut so we had a grand time cutting off the brown tips of the daffodils. There are actually several reasons why this happens. Over time, the plant will form a bare stem. 3. To remediate rhizome rot: Remove the soil around the rhizome, making sure to keep the roots intact and still in the ground. Heavily infected leaves turn brown and dry. The tips of the leaves turn brown. Q. 1. Root root is caused by either high humidity or persistently wet soil around the lavenders roots and results in brown stems and foliage with a wilting appearance. My Flower Garden Has Developed Yellow Spots On Everything. When they do, however, it can be due to a number of reasons. One of the most common causes of yellowing leaves is moisture stress. Petunia Leaves Turned Brown and Dried Out. Leaves Turn Brown and Wilt When plants have too little water, leaves turn brown and wilt. Q. An early frost, very heavy rain, or a hail storm can turn mum flowers brown and mushy overnight. The leaves were tan streaks then spread wider. This happens to many kinds of tropical plants as they grow. 1. Small, round, reddish brown spots with white to grayish white centers form on th e upper l eaf sur face. My Zinnia Plants are growing taller but some of the leaves keep turning brown, curling up and drying. Then, when cooler weather set in, I began to notice brown spots on the flowers and the leaves. Excessive water is a common result of growing a small plant in a large pot, because the plant isn't absorbing much moisture each day so the soil in the container stays soggy. Even with the best care, brown leaves are fairly common on many houseplants. So you brought home that beautiful dream plant of yours, and at some point you noticed the dreaded brown and crispy edges on the leaves. 1 Zinnias can get insect problems (aphids and spider mites) and fungal diseases (powdery mildew and black spot). Although not fatal to plants, powdery mildew makes the foliage unattractive and repeated bouts of the disease will gradually weaken the plant. They are placed in direct sunlight. CAUSE: Thrips are minute (less than 1/25 of an inch) insects that can be yellow, brown or black. Keep in mind that it might be perfectly natural for the lower leaves on your plant to first turn pale yellow, then turn brown and drop off. The reason why lavenders turn brown is because of the fungal disease root rot. Leaves turn brown and wilt when plants have too little and too much water. One of the quickest, first signs of overwatering to observe occurs at the tip of the leaf. Whenever possible, water in a manner that keeps the leaves dry to inhibit this seedborn disease. SYMPTOMS: Silver or bronze colored streaks on leaves, which eventually turn brown, dry and crumbly. If so, just ignore the mildew; it doesn't kill the plant and we strip the leaves off when we use zinnias in bouquets anyway. Reddish brown circular spots up to ½ inch in diameter appear on leaves and petals; Centers of spots turn grayish white; Center of an older spot may fall out giving the leaf a shot-hole appearance; Severely infected leaves, stems, and flowers turn brown and die; Dark brown sunken lesions (cankers) are common on the stem near the soil line Dead foliage typically falls off the stem, though it will sometimes remain in place. Also, the only pest I ever had on my zinnias were snails or slugs and their damage appeared as holes or near translucent holes in the leaves. Large reddish brown or purple spots, at first round to oblong but becoming irregular in shape have gray or tan centers that may drop out leaving a hole. If your plant is not getting enough water, its leaves will start to droop so the plant can prevent excess transpiration. When I grew the 'Profussion' zinias for several years, the bottom leaves always got it. It seems to be spreading to Dahlias which are about 8\" away in same bed. Two leaf spots are often found on zinnias. Generally, there is going to be one of three things wrong if your peace lily is beginning to turn brown. It means that there is something wrong, and that if you don’t take the steps to remedy the problem, you aren’t going to have a gorgeous peace lily for much longer. 1), very similar to those caused by Xanthomonas, a bacterial pathogen of zinnia.As the disease progresses in the greenhouse, spots caused by the fungus Alternaria zinniae become larger and develop dark concentric rings. 3. Leaves turn brown and wilt. These yellow spots are spreading all over my garden and I … They are difficult to impossible to prevent, but here are some ideas for you. There are many possibilities: 1. All gardners, no matter their level of expertise, know that plant leaves are not supposed to turn black. One of the main reasons why the anthurium flowers might begin to turn brown is if you apply too much fertilizer. From 1 1/2 inch bright \"Lilliput\" zinnias developed in France in the 1880s, to double flowers that emerged in the early 20th century which eventually morphed into \"Pumila\" or \"Cut-and-come-again\" zinnias, eventually larger zinnias were developed, including the \"Giant Mammoth.\" What Causes Brown Leaves . Alternaria zinniae: Apply a fungicide. These are more compact plants with open-faced single blooms in red, orange, yellow and white. Twitter. To prevent problems, grow zinnias in full sun with plenty of air circulation. I decided to make a game of it with my 4 and 8 year old grandchildren. That's a strong indication that you’ll need to remove the soil around the rhizome to do some further investigation. You can use brown leaves in the bottom of sandwiches to add a little bit of basil flavor. For the best results, you should use as sharp a pair of scissors as possible. To fix that problem, I just put a little snail & slug bait underneath the leaves at the bottom. Use sharp scissors or kitchen shears to trim leaves. Also on bloom. I had a brilliant idea to cut off the brown damaged part of the leaves. The plants are potted in my balcony and get a good amount of indirect sunlight Please help. Recently the leaves turned dry and brown.\nMomentum Live Stream, Utas Medicine Singapore, Ics Device List, Bombers Exposure Tournament 2020, Sony Wi-c310 Waterproof, La Villa Catering, Campbell's Chicken Broth Ingredients, What Does The Ruby Red Seadragon Eat, Obagi Hydrate Facial Moisturizer Reviews, Panasonic G9 Sale, Husqvarna 460 Rancher 24 Inch Chain, Kits Warangal Fee Structure 2020,", "label": "Yes"}
{"text": "Breathing is the process that moves air in and out of the lungs. Aerobic organisms of these types—such as reptiles, birds and mammals—require oxygen to release energy via respiration, in the form of the metabolism of energy-rich molecules such as glucose. Breathing is only one process that delivers oxygen to where it is needed in the body and removes carbon dioxide. Another important process involves the movement of blood by the circulatory system. Gas exchange occurs in the pulmonary alveoli by passive diffusion of gases between the alveolar gas and the blood in lung capillaries. Once these dissolved gases are in the blood, the heart powers their flow around the body (via the circulatory system). The medical term for normal relaxed breathing is eupnea.Scientists are studying breathing-defects, and here are links about some of their research.\nIn addition to removing carbon dioxide, breathing results in loss of water from the body. Exhaled air has a relative humidity of 100% because of water diffusing across the moist surface of breathing passages and alveoli.\nResearchers at the Columbia Center for Children's Environmental Health at the Mailman School of Public Health are the first to report an association between early childhood exposure to the chemical bisphenol A (BPA) and an elevated risk for asthma in young children. BPA is a component of some plastics and is found in food can liners and store receipts.\nAccording to a new study from the Slone Epidemiology Center (SEC) at Boston University, African-American women who reported suffering abuse before age 11 had a greater likelihood of adult-onset asthma compared to women whose childhood and adolescence were free of abuse.", "label": "Yes"}
{"text": "Depends on how you plant it. It's a great midground if you bury the stem lengthwise in the substrate. It gives a canopy about 1 inch about the substrate to wherever it decides to climb, usually a few inches. Fish love swimming under it.Aada said:Thank you for the picture Wraithen! That probably is it then. Yours looks really dense and lush! Do you think it's good as a background plant, or should it be more of a midground plant? I've got it in my 60 that's 25\" tall.\nYeah, I would put the sword by the filter intake. They dont shed leaves as easily. Take it from me, leaves getting trapped in the intake helps make a nasty intake tube. Sword leaves are pretty tough, so they shouldn't have an issue.Aada said:If that's the case, I wonder if it wouldn't make more sense to purchase a larger background plant and try to move the wisteria to growing horizontally instead. They're currently in the back corner of my tank, in the area I want to be most densely planted.\nI included a picture from when this was all first planted, a month ago, but I don't have an updated picture yet. I'll get one tonight after work. So far the other plants are one Amazon sword and three aponogeton of unknown type. The aponogeton were sold as a cup of 3 bulbs, otherwise I would have only got one. The Amazon sword and aponogeton have really taken off where this one has stayed relatively tiny.", "label": "Yes"}
{"text": "The deep sea is one of the most unexplored and mysterious places on Earth. Did you know that there are animals that are completely transparent? That some tube worms live for 1,000 years? That the Pigbutt Worm is also known as the “Flying Buttocks”? Or that there is a type of sea cucumber that is nicknamed “the headless chicken monster?” These are just some of the scientific facts, presented comics-style, that kids will pore over again and again. THE DEEP! is a captivating and educational survey of animals that live in the deepest part of the ocean created in a fun graphic nonfiction format. The first-person commentary by the animals themselves cover a wealth of facts from the surface of the ocean to the darkest trenches. And the beautiful, full-color illustrations bring them to life. From animal adaptations like bioluminescence and giant flashlight eyes to the habits and habitats of the Pram Bug and Dumbo Octopus THE DEEP! will keep readers fully engaged with life at the bottom of the sea.\nTHE DEEP! is the perfect book to spark children’s interest in this strange and beautiful world. Leigh’s uniquely illustrated graphic style perfectly combines humor and education to create a book that is equally fascinating as it is factual. The rollicking, humorous dialogue between deep-sea creatures presents an exciting and memorable delivery of scientific facts.\n- 8 - 12", "label": "Yes"}
{"text": "In order to determine the goldfish respiration change adding small amounts of crushed ice to the water, than behavior will be noted gold fish lab report . Hardy weinberg goldfish lab search the site go animals and nature evolution resources basics history of life on earth if you do not have 3 gold fish, fill in . Insulin shock gold fish experiment honestly, there wasn't to much information i could find on the webbut this is good enough, and from your readings and watching, you can make a your conclusion on how insulin, blood sugar and glucose effect the body.\n3 beakers 2 goldfish/group ice goldfish respiration lab report your lab is to be neatly written in ink, or typed it will have the following components:. According to “the respiration system of a goldfish” by sarah quintal, at lower temperatures the surface area for gas exchange increases, while the breathing rate decreases . To survive, you must catch enough fish for them to eat the only food source is a small microsoft word - tragedy of the commons goldfish labdoc author:. By 110-01: scientific method lab report the goldfish were placed into 21ºc • conclude your lab report with a paragraph or two wrapping up the whole report .\nPhysiological and behavioral effects of hyperinsulinism on goldfish in a future lab there are many other goldfish and its behaviors if the fish are in a cold. ” the control fish was contained by beaker 1, and beaker 2 contained the fish that received the experimental testing two separate beakers were filled, one contained ice water, and the other contained aged water. The effect of water temperature on the breathing rate of goldfish introduction the scientific method of problem solving is a method that scientist use to. Natural selection goldfish crackers lab introduction: evolution is the change over time in the genetic makeup of a population natural selection is important in . Goldfish lab abstract--- in this lab of fishing out random goldfish, we looked at the allele frequencies in a population and how they can differ and change this lab helped me understand the concept of the hardy-weinberg law.\nThe goldfish report 23k likes the goldfish report is a collection of peoples stories, opinions, hypotheses, and and scientific theories of our time. Goldfish respiration lab problem: how does temperature affect respiration rates of fish gold fish report uploaded by ugajake 5096_s07_er uploaded by. Lab instructions and materials for the teacher: buy medium-sized feeder goldfish at a local pet store they usually sell for about 10¢ each set up two tanks: one for fish to be used by the students and one to allow the fish to recover. Answer to below are the pictures of the experiment conducted for the effect of temp on gold fish write the lab report including:.\nquestions for goldfish lab 1 what is the scientific name of the common goldfish the scientific name of the common goldfish is carassius auratus (street, 2002, p1). In class last week, we did the goldfish respiration lab, where the goal was to test how the respiration rate of a goldfish fluctuates with differences in the temperature of the water. View lab report - bio lab report from bio 1000 at kean university radia 1 application of the scientific method: the goldfish experiment vishal radia bio 1000 - section 6 9/24/2014 radia.\nGoldfish report explained purpose of the lab/research the purpose of this lab is to investigate the relationship between the change in the water temperature and the breathing rate of the goldfish. View lab report - fish lab report final draft from bio 101 at the city college of new york, cuny name: group:8 abstract oxygen is the main reason for animal survival. Gold fish lab report 152-35 professor weller 14 february 2012 effects of temperature on goldfish respiration introduction this experiment was designed to identify the effect of cold-water temperatures on the respiration rate of goldfish .\nThe conditioning of respiration rate in goldfish (carassius auratus) using water temperature and visual stimuli donna tehrani and patrick schafer. Personal energy audit and report something's fishy- population study lab lab something's fishy- population study lab: size we were asked to use goldfish . The size of the container or my lab group and i may have caused the fish to swim and be more active, thus increasing the fish’s metabolic rate and breathing rate lastly, light exposure may have changed the fish’s respiration rate.", "label": "Yes"}
{"text": "ACNE / PIMPLES\nPimples are caused by over-production of sebum, clogging of sebaceous glands and skin bacteria.\nPimples occur because of skin bacteria Propionebacterium acnes, which feeds on skin oils. During the breakdown of skin oils the formation of waste products and fatty acids occurs, which irritates the sebaceous gland and causes inflammation. It results in appearance of small red nodules, which are tender. These are being replaced by the actual pimples, containing degraded oil. The inflammation subsides after a few days or weeks, depending on how big they are, but usually it starts all over again.\nOutbreaks of acne can cause scars.\nBlackhead: Black dots.\nPapule: Small swelling, most often red.\nPustules: Slightly larger swelling with evident inflammation and pus inside.\nNodules: Clearer swelling with clear pus inside.\nCysts: Large pus filled swelling.\nOur clinics use several variations with lasers against acne / pimples. LLLT (low level laser treatment)", "label": "Yes"}
{"text": "AbstractFly ash was collected as a byproduct from the processing of southern pine wood chips in a pilot-scale biomass gasifier. General properties of the fly ash were determined to assess its applicability as a soil amendment. Its alkaline pH (9.5) and high concentrations of Ca, K, and Mg suggest that it could be used as both a liming agent and a fertilizer. The concentrations of most heavy metals in all ash samples in this study were lower than the ecological soil screening levels used as a guideline. A sequential extraction analysis was used to evaluate the bioavailability of selected nutrient elements and pollutant heavy metals in the fly ash. Most nutrient elements were present in exchangeable/acid extractable and easily reducible fractions. The heavy metals were generally less bioavailable, thus ameliorating concerns for land application of fly ash, with or without prior combustion. Comparison of sequential extraction test results for all of the ashes indicated that the conditions experienced during gasification, such as high processing temperatures, impacted both the total heavy metal concentrations and their potential bioavailabilities.", "label": "Yes"}
{"text": "We are working in partnership with the Environment Agency to plan, design, install and maintain a natural based erosion protection scheme at Wardsend - Hillsborough, Sheffield.\nThe project aims to stop the ongoing erosion of the riverbank on the edge of a historic landfill site and has been designed with the geomorphological characteristics of the River Don and the local environment in mind.\nThe scheme champions the use of natural based products such as windblown trees, cracked willow, cliff stone and root plates to create a robust, but natural way of protecting the riverbank from further erosion.\nWe will be providing a new public access path and landscaping features for greater amenity value.\nIn March 2023, the RSC team returned to Wardsend to plant over 100 willows and 100 alders at the base of the new river bank. The fast growing species are planted to try to create a layer of small trees to add roots and structure to the soil. The remainder of the new bank has been seeded using a wildflower mix of locally appropriate seeds designed for woodland and heavy shaded areas.\nThe adjacent land and sloped top of the embankment has also been planted a with a mixture of slower growing species such as silver birch, sycamore, dog wood and cherry to add to create a buffer for the former landfill area to the east of the project.\nThese two areas will be revisited later in the summer to check on the growth and carry out any required maintenance.\nBy reducing the carbon footprint of alternative man-made solutions, this method is a pioneering approach to erosion protection.\nThe gallery below shows the progress of the project, from preparation of the site for the winter weather to vegetating and planting completed in Spring 2023.", "label": "Yes"}
{"text": "Bukit Timah Nature Reserve facts for kids\nBukit Timah Nature Reserve, which is situated on Bukit Timah Hill, is the largest of the remaining patches of primary forest in Singapore. Singapore’s original tropical primary rainforest ecosystem makes up half of the reserve. At the summit of the hill, there is a rock showing the height, latitude and longtitude.\nBTNR is located just beside the Central Catchment Nature Reserve, separated by the Bukit Timah Expressway (BKE). BTNR is the only remaining primary forest in Singapore. It covers a total area of 163 hectares and occupies just 0.2% of Singapore's land.\nAccessibility from other nature areas/forests\nBTNR is easily accessible from Dairy Farm Nature Park, as well as the MacRitchie Reservoir in the neighbouring Central Catchment Nature Reserve. Dairy Farm Nature Reserve is connected to the Yellow Trail via the Dairy Farm Loop, while the MacRitchie Reservoir is connected to BTNR by the Kampong Trail.\nIn 1825, one of Singapore's first colonial administrators, John Crawfurd, climbed the hill. He said that the surrounding forest was so dense that sailing to Calcutta was almost as easy as reaching Bukit Timah. In 1843, the access road to the summit was built. 40 years later, BTNR became the first forest reserve in Singapore to be conserved. The reserve has been protected by law since 1939, when the reserve was threatened by nearby granite quarrying at Hindhede Quarry. Till the late 1980s, BTNR was still part of the CCNR. Then, the government decided to build the BKE through the CCNR, thus splitting the CCNR and forming the BTNR. In 1991, the newly formed NParks, which manage Singapore's parks, nature reserves, and roadside trees, conducted a visitor survey. After gathering all the feedback, they began to develop facilities to improve visitors' experience at the reserve. and at the same time, reduce the damage that visitors might cause to the reserve. Over time, trails started to penetrate parts of the forest which were richer in biodiversity, causing plant and animal numbers to decrease. The ground surface was also damaged and soil erosion occurred. As a result, those trails were closed, and the main trails were upgraded.\nDuring the 2 decades that followed the separation of BTNR from CCNR, nature lovers complained about the separation of biodiversity in the BTNR and CCNR. They said that animals from each nature reserve could not cross over to the other reserve, and wanted a link to connect the two reserves, so as to allow animals to move about from one reserve to the other. In 2005, some nature lovers and government authorities agreed to build a bridge to link the two reserves. Work to build the Eco Link began on 30 July 2011 and was completed in the 3rd quarter of 2013. Trees to create a natural environment were planted on the bridge after it was completed.\nBeing home to more than 840 flowering plants and 500 species of animals, it contains 40% of Singapore's flora and fauna. A common tree there is the Seraya (Shorea curtisii), which dominates the forest canopy of BTNR. Rare plants such as the Mock Durian (Neesia synandra) can also be found there. The Mock Durian, as its name mentions, produces fruit that look like durians, but they are inedible. Forest Praying Mantis and the Singapore Freshwater Crab are some of the rare animals found there. Pangolins, Horsfield's Flying Squirrel, Plaintain Squirrel, Malayan Colugo, also known as the Malayan Flying Lemur, as well as the Giant Forest Ant all live at BTNR. There are also many Long-tailed Macaques, which is the most common monkey in Singapore. Other than that, BTNR also has rich bird and insect life. Cicadas can be heard everywhere. Many species of birds and butterflies can also be spotted there. However, the birds, like the cicada, are more often heard than seen. Some of the birds spotted there are the Greater Racket-tailed Drongo, Asian Fairy Bluebird, Red-crowned Barbet and Emerald Dove. In March 2011, a Dot-Dash Sergeant (Athyma kanwa), which is a rare butterfly in Singapore, was spotted along the Red Trail. Some of the other butterflies spotted there include the Common Faun (Faunis canens), Common Caerulean (Jamides celeno) etc. One species of monkey, the crab-eating macaque is common in the park.\nBTNR consists of 4 trails, namely the Red Trail, Blue Trail, Green Trail and Yellow Trail. The starting point of all the trails is the same, and at 40m above sea level. There are poles lining the various trails, with the colours of the trail(s) pasted on them.\nThe Red Trail is the main trail that brings people from the foot of the hill to the summit. To get to the rest of the trails, one has to walk up a part of the Red Trail first. The Green and Yellow Trails are basically detours into the forest, as they will still lead back to the Red Trail when reaching the summit. The 1.2km-long Red Trail, which is made of tarmac, is the one of the two easiest trails to climb. A trip up to the summit takes about 30 minutes while a return trip takes about 25 minutes.\nThe Blue Trail is the shortest of all trails, and is the second of two easiest trails to climb. The 0.7km-long Blue Trail starts off on the Red Trail itself, before breaking away halfway to lead to the Hindhede Quarry, at a height of 140m. An ascending trip takes about 20 minutes while a trip back to the foot of the hill takes about 18 minutes.\nThe Green Trail is 1.1km long. An ascend takes 30 minutes while a descend takes 25 minutes.\nThe Yellow Trail is the toughest of all trails. It surrounds the Jungle Fall Valley. Hikers start by walking up the Red Trail, then walking into the forest. The Yellow Trail cuts into the Jungle Fall Path in the dense forest near the summit, at a height of 150m, and hikers have to descend and ascend many steps along the way. Generally, the trail descends sharply until reaching the Singapore Quarry, before ascending sharply again. When it reaches the Singapore Quarry, it is only 100-110m above sea level. After that, the trail ascends until it joins back the Red Trail. By then, it is almost reaching the summit already. The trail is 1.8km long, and a summit-bound hike takes about 1 hour 10 minutes to 2 hours, while a return trip takes at least 55 minutes or more.\nOther than the 4 main trails, there are also other trails that are not part of the main trails. There are a few of this \"paths\".\nBTNR is a popular place for many Singaporeans. Everyday, many people go there to jog, hike, or for a stroll. There is also a 6km long Mountain Biking Trail for mountain bikers to cycle. The mountain biking trail goes around the reserve, going along the green corridor where the old KTM trains used to pass by, then passing by the Singapore Quarry, followed by Dairy Farm Nature Park and the Bukit Timah Expressway (BKE), then near Rifle Range Road before back to the carpark where the trail starts.\nASEAN Heritage Park status\nBTNR is the second ASEAN Heritage Park in Singapore, after Sungei Buloh Wetland Reserve. BTNR was granted this status on 18 October 2011.\nBy the 1990s, Singaporeans had started to get interested in nature. Visitor numbers have rose sharply since then, with 88,000 visitors in 1990, and 400,000 just 8 years later.\nImages for kids\nCrab-eating macaque near the summit of Bukit Timah\nBukit Timah Nature Reserve Facts for Kids. Kiddle Encyclopedia.", "label": "Yes"}
{"text": "Breastfeeding creates a tremendous calcium demand. In contrast to pregnancy, the skeleton is the main source of calcium. Therefore, a loss of bone occurs but is transient. Bone density is usually restored within six months after weaning your baby. The good news is breastfeeding does not appear to be associated with increased risk of fractures in later life.\nCalcium intake during breastfeeding follows the recommendation for your age. For women 19 and older, the daily recommended intake is 1000 milligrams. More than this is not needed. Also be sure you are taking sufficient vitamin D. Vitamin D is needed for absorption from your intestines.", "label": "Yes"}
{"text": "Home » Misc » Can you get pregnant during fertility days\nCan you get pregnant during fertility days\nRight Time For Sex , When Do You Ovulate ?\nWhen are you more likely to conceive?\nWe’re talking about the 'fertile window’ – the days in a woman’s menstrual cycle when pregnancy is possible. The ‘fertile window’ depends on the length of the menstrual cycle, which varies among women.\nThe ‘fertile window’ is the day an egg is released from the ovary (ovulation) and the five days beforehand. Having sex (intercourse) during this time gives you the best chance of getting pregnant.\nWhat day did you your most recent period start?\nNumber of days in your cycle Please select20 Days21 Days22 Days23 Days24 Days25 Days26 Days27 Days28 Days29 Days30 Days31 Days32 Days33 Days34 Days35 Days36 Days37 Days38 Days39 Days40 Days41 Days42 Days43 Days44 Days45 Days\nYour ovulation day\nMost fertile time\nWhat is an ovulation calculator and how does it help you get pregnant?\nThis ovulation calculator or ovulation calendar can help you work out your most fertile time. These are the days you are most likely to get pregnant.\nIt can also estimate your due date if you do become pregnant during your next fertile days.\nOthers ways to help you work out when you're ovulating:\nNotice changes in vaginal mucus\nA few days before ovulation, you may notice your vaginal mucus becomes clear, slick and slippery, and feels a bit like egg white.\nThis is a sign that ovulation is about to happen. It’s the best time to have sex, as sperm travel more easily in this kind of mucus.\nUse an ovulation predictor kit\nYou can use a predictor kit from a supermarket or pharmacy, to test your urine for signs of ovulation. If you start testing your urine a few days before the day you next expect to ovulate, a positive result means you are going to ovulate within the next 24 to 36 hours (one to two days).\nFacts about timing\nOvulation is when a mature egg is released from the ovary. The egg then moves down the fallopian tube where it can be fertilised. If sperm are in the fallopian tube when the egg is released, there is a good chance that the egg will be fertilised, creating an embryo, which can grow into a baby.\nPregnancy is technically only possible if you have sex during the five days before ovulation or on the day of ovulation. But the most fertile days are the three days leading up to and including ovulation. Having sex during this time gives you the best chance of getting pregnant.\nBy 12-24 hours after ovulation, a woman is no longer able to get pregnant during that menstrual cycle because the egg is no longer in the fallopian tube.\nThere’s almost no chance of getting pregnant if you have sex before or after the fertile window (but if you’re not trying to get pregnant, don’t rely on this – contraception is your best option!).\nHow to know when you’re ovulating\nKnowing when you ovulate can help you plan for sex at the right time and improve your chance of getting pregnant. You can keep track of your menstrual cycles on a chart, in a diary, or on a free period-tracker app on your smartphone.\nTo work out the length of your menstrual cycle, record the first day you start bleeding (first day of your period). This is day 1. The last day of your cycle is the day before your next period begins.\nWhat is a ‘menstrual cycle’ and a ‘period’?\nSome people think the ‘menstrual cycle’ and a ‘period’ are the same thing.\nA period is when you bleed (or menstruate).\nA menstrual cycle starts on the day when a period starts (day 1) and ends the day before the next period. A cycle’s length is considered normal if it’s between 21 and 35 days. They can vary between women and from one cycle to the next.\nWorking out your ‘average’ menstrual cycle length\nIf your menstrual cycles are different lengths (most women’s cycles are) you can work out your average cycle length.\nThe number of days in a woman’s menstrual cycle can vary month to month. Periods are not always regular. It can be useful to work out an ‘average’ cycle length, based on the length of three menstrual cycles, to estimate when you’re most likely to be ovulating.\nIf you add the number of days in three cycles and divide the total number by three, it gives you your average cycle length.\nSarah tracked her last three menstrual cycles by counting the time from the first day of one period, to the day before the next period.\nCycle 1 was 28 days; Cycle 2 was 32 days; Cycle 3 was 27 days\n28 + 32 + 27 = 87\n87 divided by 3 = 29\nSo the average length of Sarah’s menstrual cycles is 29 days.\nWorking out your most fertile days\nWhen you know your average menstrual cycle length, you can work out when you ovulate.\nOvulation happens about 14 days before your period starts.\nIf your average menstrual cycle is 28 days, you ovulate around day 14, and your most fertile days are days 12, 13 and 14.\nIf your average menstrual cycle is 35 days ovulation happens around day 21 and your most fertile days are days 19,20 and 21.\nIf you have shorter cycles, say 21 days, ovulation happens around day 7 and your most fertile days are days 5, 6 and 7.\nYour most fertile days are the three days leading up to and including the day of ovulation.\nSome women have very irregular cycles or find it difficult to work out an average cycle length. This can make it hard to work out when ovulation happens. If it’s all too hard, having sex every 2-3 days covers all bases and improves your chance of getting pregnant.\nA woman can get pregnant any time of the month.\nA woman can only get pregnant on a few days during her menstrual cycle.\nBecause eggs and sperm only live for a short time:\nSperm live for around five days.\nEggs can only be fertilised for around 24 hours (one day) after being released from the ovary.\nEggs and sperm need to come together at the right time for fertilisation to happen to create an embryo.\nGetting the timing right\nIf you're trying to get pregnant, timing is everything. Dr Karin Hammarberg explains how to work out when you are ovulating and the right time to have sex to improve your chance of pregnancy.\nWhat are the chances?\nHaving sex as close as possible to the time of ovulation increases the chance of pregnancy.\nIf a woman has sex six or more days before she ovulates, the chance she will get pregnant is virtually zero.\nIf she has sex five days before she ovulates, her probability of pregnancy is about 10 percent.\nIf she has sex on the day of ovulation, or the two days before, the chance of getting pregnant is around 30 percent.\nThese are average figures and depend on a woman’s age.\nWhen does preconception health begin?\nProfessor Sarah Robertson, Director of Robinson Research Institute, University of Adelaide, highlights the key time before pregnancy that your health is most important to ensure your child has the best start to life.\nHow to know you are ovulating\nKerry Hampton, a registered nurse and fertility specialist, discusses the importance of fertility awareness, and how to determine your fertile window to improve your chances of conceiving.\nAmerican Society for Reproductive Medicine, Optimizing natural fertility, https://www.reproductivefacts.org/news-and-publications/patient-fact-sheets-and-booklets/documents/fact-sheets-and-info-booklets/optimizing-natural-fertility/\nBerglund Scherwitzl, et al. (2015). Identification and prediction of the fertile window using Natural Cycles. The European Journal of Contraception and Reproductive Health Care, 20(5), 403-408. doi:10.3109/13625187.2014.988210\nEcochard, R., et al. (2015). Self-identification of the clinical fertile window and the ovulation period. Fertility and Sterility, 103(5), 1319-1325.e1313. doi: http://dx.doi.org/10.1016/j.fertnstert.2015.01.031\nPfeifer, S., et al. (2017). Optimizing natural fertility: a committee opinion. Fertility and Sterility, 107(1), 52-58. doi: 10.1016/j.fertnstert.2016.09.029\nStanford, J. B. (2015). Revisiting the fertile window. Fertility and Sterility, 103(5), 1152-1153. doi: http://dx.doi.org/10.1016/j.fertnstert.2015.02.015\nStanford, et al. (2002). Timing intercourse to achieve pregnancy: current evidence. Obstetrics and Gynecology, 100(6), 1333-1341.\nStephenson, J., et al. (2018). Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. The Lancet, 10.1016/S0140-6736(18)30311-8 doi: 10.1016/S0140-6736(18)30311-8\nVélez, M. Pet al. (2015). Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study. Fertility and Sterility. doi: 10.1016/j.fertnstert.2015.01.005\nVerón, G. L., et al. (2018). Impact of age, clinical conditions, and lifestyle on routine semen parameters and sperm kinematics. Fertility and Sterility, 110(1), 68-75.e64. https://doi.org/10.1016/j.fertnstert.2018.03.016\nWaylen, A. Let al. (2009). Effects of cigarette smoking upon clinical outcomes of assisted reproduction: a meta-analysis. Hum Reprod Update, 15(1), 31-44.\nZenzes, M. T. (2000). Smoking and reproduction: gene damage to human gametes and embryos. Hum Reprod Update, 6(2), 122-131.\nPage created on: 28/08/2018 | Last updated: 21/10/2022\nWhen am I most fertile? How to calculate your ovulation cycle\nWhen trying to conceive, it can be helpful to know when ovulation occurs and when a person is most fertile. Some people may wish to track their fertile window to avoid pregnancy.\nFemales are most fertile within a day or two of ovulation, which is when the ovaries release an egg. But, it is possible to get pregnant in the days leading up to ovulation, as sperm can survive for several days inside the female body.\nThe days during the menstrual cycle when a person is least likely to get pregnant are known as the ‘safe period.’\nThis article describes how to calculate the fertile window to aid or avoid conception.\nA note about sex and gender\nSex and gender exist on spectrums. This article will use the terms “male,” “female,” or both to refer to sex assigned at birth. Click here to learn more.\nThe average person’s menstrual cycle is between 28–32 days. Some people have shorter cycles, while others have much longer ones.\nThe first day of a person’s period is considered the first day of their menstrual cycle. Their period then typically lasts 3–7 days.\nVariations in the menstrual cycle usually happen in the follicular phase that occurs before ovulation.\nThe luteal phase, which occurs from ovulation to the next period, is typically 14 days long.\nLearn more about the phases of the menstrual cycle here.\nOvulation occurs when one of the ovaries releases an egg. After release, the egg moves to the fallopian tube, where it will travel to the uterus, which takes about 24 hours.\nPregnancy occurs if sperm travels to the fallopian tube and fertilizes the egg. If sperm does not fertilize the egg, the egg moves to the uterus and breaks down, ready to leave the body during the next menstrual period.\nLearn more about sperm here.\nAccording to the American College of Obstetricians and Gynecologists, ovulation occurs around 14 days before a person expects to have their next period if their monthly cycle is 28 days.\nMost people ovulate between days 11–21 of their cycle. The first day of their last menstrual period (LMP) is day 1 of the cycle. Ovulation does not always occur on the same day every month and can vary by a day or more on either side of the expected date.\nDoctors call the part of the cycle around ovulation the fertile window because the chance of pregnancy is highest at this time. For example, if ovulation occurs on day 14, a person can conceive on that day or within the following 24 hours.\nHowever, their fertile window begins a few days before ovulation because sperm can survive for up to 5 days inside the female body. So, even if a person does not have sex on day 14 or 15, it is still possible to become pregnant if they had sex without using contraception on days 9-13.\nAccording to research from 2018, the likelihood of conception rises from day 8, reaching its maximum on day 13 and decreasing to zero by day 30.\nHowever, It is essential to note that these findings should only act as a guideline. Every person and every cycle is different.\nIt can be helpful for a person to chart their monthly cycle and take note of the signs of ovulation to help pinpoint the exact day of ovulation each month.\nLearn more about ovulation here.\nSigns of ovulation\nTracking the signs of ovulation can help someone determine the precise day they ovulate each month.\nmild cramping in the lower abdomen\nwetter, clearer, and more slippery vaginal discharge similar to egg white\na small increase in basal body temperature\na higher sex drive\nSome of these signs, such as basal body temperature, will continue to change after ovulation. For this reason, a person should not use temperature to predict the fertile window.\nIt may be helpful for someone to track the signs over a few months to get an idea of what is typical for their body.\nBut they should keep in mind that there are several variables, and the timing of ovulation can change, month-to-month.\nAnother option is to use an ovulation predictor kit or fertility monitor.\nFertility aids measure the levels of specific hormones in the urine to determine the ovulation day each month. Some devices also identify days of peak fertility.\nUsing a combination of these methods may provide an individual with the best accuracy.\nThe following table, based on research from 2015, summarizes a typical menstrual cycle and how fertile a person is likely to be at each stage:\nDay of cycle\nleast fertile stage\npossible to conceive\ndays around ovulation\npossible to conceive\nthickening of uterine lining\nless fertile — unlikely to conceive\nTo get a more specific range of highest fertility windows based on the day of ovulation, a person can track the first day of their last period in a pregnancy calculator.\nLearn more about how to track ovulation here.\nTo maximize the chances of becoming pregnant, a person should time sexual intercourse to occur during the 2–3 days leading up to, and including, ovulation. Having sexual intercourse on any of these days may provide a 20–30% chance of pregnancy.\nOther tips to improve the chances of conception include:\nHave regular sexual intercourse. Pregnancy rates are highest among partners who have sex every 2 or 3 days throughout the month.\nAvoid smoking. Smoking tobacco reduces fertility and impacts the health of a developing fetus.\nLimit alcohol intake. Alcohol intake can reduce fertility in males and females and harm a fetus.\nMaintain a moderate weight. People who have overweight or underweight are more likely to have irregular ovulation.\nReduce stress: While the research on whether anxiety or stress can reduce fertility is not conclusive, it is clear that reducing stress can provide some benefit for a person trying to conceive.\nManage comorbidities: Rule out or treat any medical causes that may contribute to infertility. In females, this can include hormonal problems, endometriosis, polycystic ovary syndrome (PCOS), uterine fibroids, autoimmune disorders, and more.\nA doctor can assess a couple’s overall health and may be able to identify methods to improve the probability of conception.\nLearn more about infertility in males and females here.\nWhat can affect male fertility?\nEven if a person is having regular sexual intercourse and tracking ovulation, there can be reasons why the sperm cannot reach the egg.\nCauses of male infertility include:\nSperm morphology: Differences in the size and shape of the sperm can impact fertility.\nLow sperm count: The male partner’s ejaculate fluid does not contain sufficient sperm. Fertility doctors consider a person to have a low sperm count if they have under 15 million sperm per milliliter of semen — the fewer the sperm, the lower the chances of conception.\nLow sperm motility: This means the sperm cannot move as efficiently to reach the egg.\nThere are a variety of medical conditions that can cause any of these problems with male fertility, including a hormonal imbalance, infection or injury to the testicles, surgery in the area, and diseases such as cancer.\nLearn more about sperm count here.\nSome people may wish to track their fertility to prevent pregnancy. This is known as the fertility awareness method.\nThe Centers for Disease Control and Prevention (CDC) charts fertility awareness-based methods of contraception as having a 24% failure rate with typical use.\nThe chances of pregnancy are lowest during a person’s period and on the days on either side of the period.\nHowever, they may still become pregnant if they have ovulated early or late in their cycle, as sperm can survive in the body for several days.\nPeople wishing to use the fertility awareness method should speak with their doctor first.\nLearn more about the types of contraception available here.\nOvulation and the fertile window can change from cycle to cycle, but they may also alter with age. Fertility naturally begins to decline in females in their 30s. By age 40, a person’s chance of conceiving drops to 10% per cycle.\nThe number of eggs and egg quality decrease with age. Ovulation may also become irregular.\nSome medical conditions, such as endometriosis or PCOS, also make conception more difficult.\nLearn more about PCOS and fertility here.\nBirth control pills aim to prevent unintended pregnancy. The pill prevents pregnancy by releasing synthetic hormones that stop ovulation from occurring and the uterus lining from thickening.\nSo, even if the ovaries do release an egg, a fertilized egg would be unable to implant in the wall of the uterus. The pill also thickens cervical mucus, making it harder for sperm to reach an egg.\nAccording to the CDC, the birth control pill is more than 99% effective with perfect use but only 91% effective with typical use. This means that around 9 out of 100 women would become pregnant in a year of taking the pill with typical use.\nLearn more about the pill and its potential side effects here.\nFemales who track their fertile window with the aim of getting pregnant should see their doctor for preconception planning.\nAs well as identifying barriers to conceiving, a doctor can advise on the use of folic acid or prenatal supplements to encourage a safe pregnancy.\nMost couples who have frequent sex without contraception will conceive within 12 months.\nWomen under 35 years of age should see their doctor if they do not conceive after a year of trying. Those over 35 years of age should seek medical advice after 6 months of trying to conceive.\nAnyone who has irregular cycles or does not appear to ovulate should also speak with their doctor. There may be an underlying medical cause that is preventing ovulation and conception.\nLearn more about irregular periods and pregnancy here.\nHere are the answers to some frequently asked questions about when pregnancy can occur.\nCan I get pregnant 2 days before my period?\nDays 17-28 before the first day of a person’s period are the days when the uterine lining begins to thicken. While a person is less likely to conceive during this time, conception is still possible.\nLearn more about the uterine lining here.\nCan I get pregnant on my period?\nAlthough pregnancy is still possible, a female is less fertile while on their period.\nLearn more about getting pregnant during a period here.\nHow many days after your period can you get pregnant?\nA female can get pregnant at any time during her menstrual cycle. The likelihood of pregnancy is highest during ovulation, which is typically days 10-14.\nIntermenstrual bleeding can occur between periods. To pinpoint the start of a menstrual cycle, a female must correctly identify their actual period.\nLearn more about bleeding between periods here.\nEach person’s menstrual cycle is different. Generally, it lasts 28–32 days. A person is at their most fertile during ovulation, which occurs around days 10–14.\nA person can calculate the exact days of ovulation each month by counting from the first day of their period.\nHowever, certain medical conditions may affect ovulation or impact the sperm’s ability to reach the egg.\nPeople who have been unable to conceive for over a year should talk with a fertility specialist.\nRead the article in Spanish.\nWhen is a woman most fertile?\nIf you are a woman taking precautions to prevent pregnancy, or if you are thinking about pregnancy in some way in the future, the issue of fertility usually remains in the background.\nThe question of when a woman is most fertile has two aspects.\nFirst, is the menstrual monthly cycle and the period when a woman is most fertile.\nTo figure out the arithmetic, a fertility calendar or an ovulation calculator will help. The second aspect of the question concerns biological age and the stage of life at which women are most fertile. In our article, we will look at the monthly cycle, the days that are the most fertile during this cycle, and various means of monitoring and predicting ovulation. This makes it possible to predict the time of maximum fertility with some accuracy.\nSecond , we look at the stages of fertility at various times in a woman's life and their impact on her ability to conceive.\nIt is well known that fertility peaks at age 20 and begins to decline after age 30; after 35 years, natural conception rates begin to drop sharply. However, in today's society, many women, for understandable financial and social reasons, choose to delay childbearing until the age of thirty. Thus, we are faced with the paradoxical situation where many women, who have long sought to prevent pregnancy in their younger years, find themselves in a situation where they begin to look for ways to increase their chances of conceiving.\nWhen is a woman most fertile? What does the menstrual cycle show?\nIn a woman, the ability to conceive is maximum a day or two before and after ovulation. This is when the egg is released from the ovaries. You can calculate with a reasonable degree of accuracy when ovulation will occur, especially if your cycle is regular, anywhere between 24 and 35 days. Consider the start of your period (bright spotting) as the first day of your cycle, and the day before the next as the end of your cycle. Ovulation usually occurs 12-16 days before the start of the next cycle. Thus, if you have a regular 28-day cycle, then the indicator remains the same: ovulation occurs on the 12th-16th day. However, fertile time is not limited to these few days. Remember that you can get pregnant if you have unprotected sex at any time during the week before ovulation, as sperm can live in a woman's genital tract for up to seven days.\nFertility specialists generally advise that if you are hoping to get pregnant, it is advisable to specifically schedule contacts around this time, as it can be difficult to calculate the exact day of ovulation, and trying to have sex on a schedule can cause unnecessary stress and anxiety. For the best chance of getting pregnant as long as there are no underlying fertility problems, it is recommended to have intercourse every 2-3 days during your cycle. In addition, fertility calendars, an ovulation test, and self-monitoring for signs of ovulation can help predict the ideal time to conceive.\nIt could be an old-fashioned pen and paper, a spreadsheet, or one of the many online calendars available. They are also known as ovulation calendars or ovulation calculators. They all do the same thing: keep track of your menstrual cycle dates and use the 12-16 day calculation outlined above to determine the days on which you are most likely to conceive.\nThese are test kits that measure the level of luteinizing hormone (LH) in your urine. The essence of the measurement is to capture the surge in LH levels that occurs during your cycle a couple of days before ovulation. There are also tests that measure the same hormone pulsation but use a saliva sample. In these tests, saliva takes on the appearance of a fern-like pattern when it dries on glass. However, the most accurate analysis that allows you to track the LH peak is a urinalysis (rarely used in routine practice).\nSelf-monitoring for signs of impending ovulation\nSelf-monitoring includes taking temperature every morning after waking up, as well as monitoring the quality and consistency of vaginal mucus secretions. This must continue for several months so that ovulation can be tracked. This is the least reliable of the methods, because there can be many different causes of body temperature fluctuations (night rises, colds, blood sugar fluctuations), and in fact, many girls rightly find this procedure tedious and difficult to perform.\nFertility and pregnancy: misconceptions Gynecology clinic\nWomen's CD Supervisor\nGynecologist, specialist in assisted reproduction.\nIs it as easy to get pregnant at 30 as at 40? Does \"headstand\" after intercourse help \"lazy\" spermatozoa to fertilize an egg? Is it possible to get pregnant at any time of the month? Is it possible to get pregnant before menopause?\nAlthough we live in the information age, where access to knowledge is more universal, we often do not realize how little we know about subjects of great personal importance, such as fertility and pregnancy. In the XNUMXth century, we continue to listen and accept as good hoaxes, myths and false beliefs that hinder or prevent the possibility of achieving the desired pregnancy.\nQuestions about fertility and pregnancy\n1.- Nowadays, getting pregnant at 30 is just as easy as getting pregnant at 40.\nNo matter how healthy we lead and how prepared and motivated we feel, the chances of getting pregnant at 40 are much lower than at 30, because the older we get, the lower and worse the quality of the eggs.\nA healthy lifestyle will increase the chances of success, but we are very mistaken if we think that we can postpone the desire for pregnancy much longer than at other times.\nAt age 30, a healthy, fertile and sexually active woman (not using contraceptives) has a \"total\" chance of getting pregnant during any given cycle, about 20%.\nAt 40 without medical care, the probability is only 5% in each cycle, and at 45 the probability is even lower.\nWait 12 months before seeing a fertility doctor.\nA woman under the age of 30 may wait the recommended 12 months before consulting a fertility specialist.\nBut a woman over 35 years of age should consult a specialist if after 6 months of trying she has not become pregnant, to find out the reasons and start the best treatment for infertility.\nAnd if you are over 38, don't wait a day, and from the moment you decide to seek pregnancy, contact a reproduction specialist.\nHandstand after intercourse increases the chances of pregnancy.\nThere is no research showing that raising the legs, placing a pillow under the hips, or doing a headstand after sex increases sperm motility or facilitates their movement to the egg.\nAlso, there are no certain sexual positions that promote pregnancy more than others, or, as some even claim, that allow you to determine whether the child is a girl or a boy.\n4.- Age does not affect male fertility.\nAge affects the quality of sperm and therefore reduces fertility in men.\nOverweight or obesity, tobacco and/or alcohol use, or long-term unbalanced diet are circumstances that can reduce fertility in both men and women.\n5.- Smoking does not reduce fertility: neither for me nor for my partner.\nSmoking does reduce fertility in both women and men, including when looking for pregnancy. assisted reproduction. According to the American Society for Reproductive Medicine (ASRM), more than 10% of infertility cases can be attributed to tobacco use.\nIn men, in addition to erectile dysfunction or impotence, tobacco causes a decrease in the number of spermatozoa and reduces their motility.\nSo, if you're planning to get pregnant, start by taking care of your health: quit smoking (both you and your partner), eat a balanced and healthy diet, and exercise regularly.\n6.- Before menopause, you have time to get pregnant.\nThe presence of menstruation does not mean that fertility remains unchanged. From the age of 35, a woman's ovarian reserve begins to decline rapidly, and from that moment on, the chances of getting pregnant decrease.\nBleeding does not always lead to ovulation. Depending on the age of the woman and the regularity of the cycles, there may be bleeding without ovulation.\nSo you can have periods before menopause, but it's not always possible to get pregnant without medical help.\nYou must have sex every day to get pregnant\nIt is not \"mandatory\" and it is not recommended to have sex every day to achieve pregnancy because the woman cannot fertilize every day of the cycle and the man needs to restore the quality of his sperm.\nThe most fertile or most favorable time is when the mature egg leaves the ovary and enters the fallopian tubes. This process occurs approximately 14 days after menstruation.\nSince sperm can only survive a maximum of two or three days after intercourse, it is best to have sex just before or during ovulation and every other day to maintain a good sperm count.\nIn general, it is recommended to maintain a relationship from 7-10 days from the first day of menstruation during the week before alternating days.\nBut what is certain is that we should not get hung up on this.\nWomen next to you\nIf you need more information or have any questions, feel free to contact us:", "label": "Yes"}
{"text": "Ben Phelan at Slate writes about the recent evolution of lactase persistence: “The Most Spectacular Mutation in Recent Human History”.\nThe plot is still fuzzy, but we know a few things: The rise of civilization coincided with a strange twist in our evolutionary history. We became, in the coinage of one paleoanthropologist, mampires who feed on the fluids of other animals. Western civilization, which is twinned with agriculture, seems to have required milk to begin functioning. No one can say why. We know much less than we think about why we eat what we do. The puzzle is not merely academic. If we knew more, we might learn something about why our relationship to food can be so strange.\nI wanted to quote that passage because it was my friend Greg Cochran’s son Roddy who coined the term “mampires”, which is exceptionally clever. On the article as a whole, I think Phelan makes too much of the “mystery” aspect of the advantage of lactase persistence. There are really only two serious hypotheses and none of the possible explanations are mutually exclusive. I would have liked to see the article devote more attention to the multiple lactase persistence mutations in other populations, which together point to the very great advantage of the trait in association with dairying.\nDavid Dobbs writes in the New York Times about the genetics of intelligence and what we know (and don’t know) about it: “If Smart Is the Norm, Stupidity Gets More Interesting”. The piece emphasizes that geneticists haven’t had much luck finding genes that explain the heritability of intelligence. The problem of “missing heritability” has loomed over complex trait genetics for the last several years, meaning that we can estimate the heritability of traits with twin studies and other traditional pedigree approaches, but single gene loci do not account for much of the variance of these traits. One possibility is that common genes have such small effects that they are statistically difficult to find.\nAnother possibility is that very rare genes of small effect – or new mutations – may explain the heritability of such traits within families. The most likely reason for large-effect mutations to be rare is if they are deleterious. Across a population, this hypothesis of many rare deleterious mutations is called “genetic load”:\nBut in some other genetic realms we do differ widely, for example, mutational load the number of mutations we carry. This tends to run in families, which means some of us generate and retain more mutations than others do. Among our 23,000 genes, you may carry 500 mutations while I carry 1,000.\nMost mutations have no effect. But those that do are more likely to bring harm than good, Dr. Mitchell said in an interview, because there are simply many more ways of screwing something up than of improving it.\nThis is a nicely balanced treatment and emphasizes evolutionary approaches in an accessible way for Times readers.\nFrom the San Jose Mercury News, a story by Lisa Krieger: “Open-source science helps San Carlos father’s genetic quest”.\nOne tiny flaw in one gene in one little girl. That explains why Beatrice Rienhoff, 8, is so lean and leggy.\nNo one else in her family had such a syndrome. In fact, apparently no one else in the world did either.\nRienhoff -- a biotech consultant trained in math, medicine and genetics at Harvard, Johns Hopkins and the Fred Hutchinson Cancer Research Center in Seattle -- launched a search.\nYes, you can do this now. This father is now making transgenic mice with his daughter’s mutation to better understand its effects.\nKen Weiss writes about some of the reasons a family medical history is a better predictor of individual health than genotyping: “23andLess”.\nThe most likely truth at this stage is that such common traits like heart disease or how tall or heavy you are, are determined by a very large number of genes, mostly with individually very small effects. Each person with the 'same' trait--each diabetic, say--has that trait for a different genetic reason. Individual genetic variants may be causal contributors, but they are not very important.\nI agree with his point…although as I was reading the post, it occurred to me that doctors treat family history as if it were much more effective than it should be, if causal variants really have small effect sizes. Complex disorders are not the same as Mendelian disorders with low penetrance. Having a grandfather with heart disease, for example, should mean substantially less to you than having a grandfather who is tall.", "label": "Yes"}
{"text": "Stage set for checkpoint inhibitor showdown in lung cancer\nThe rivalry between Merck & Co and Bristol-Myers Squibb (BMS) in melanoma has now been extended into lung cancer – but the winner of the contest is hard to predict.\nEarlier this month, BMS scored the first US FDA approval for a PD-1 inhibitor in non-small cell lung cancer (NSCLC), getting a green light for its Opdivo (nivolumab) drug as a second-line treatment for patients with the squamous cell form of the disease.\nMerck struck back shortly afterwards, claiming US approval for its Keytruda (pembrolizumab) as a second-line therapy for all NSCLC patients – i.e. squamous and non-squamous – provided their tumours test positive for expression of PD-L1, the ligand that binds to the PD-1 receptor.\nLate last week, BMS seemed to have pulled ahead of its rival with an FDA approval to extend Opdivo’s label to include non-squamous as well as squamous NSCLC, and no need for a biopsy to check for PD-L1 status.\nAs a result, the success of the two drugs in NSCLC appears to hinge on how much importance doctors and healthcare payers attribute to PD-L1 expression as a predictor of response, something that was addressed by the FDA in its press release on Opdivo’s latest approval.\n“There is still a lot to learn about the PD-1/PD-L1 pathway and its effects in lung cancer, as well as other tumour types,” commented Richard Pazdur, who is in charge of the FDA’s Office of Hematology and Oncology Products.\n“It appears that higher expression of PD-L1 in a patient’s tumour predicts those most likely to benefit,” he added.\nBMS points to high survival rates for Opdivo monotherapy, regardless of PD-L1 expression, as evidence that its broad-based approach is valid. Meanwhile, Merck has also acknowledged that the picture is far from clear.\nThe company’s R&D chief Roger Perlmutter said earlier this year that while the likelihood of a response to Keytruda was higher in patients with 50 per cent or greater PD-L1 expression, it had seen responses in patients with low, or even zero, levels of the biomarker.\nNevertheless, with both Opdivo and Keytruda costing upwards of $100,000 a year, the big question now is whether payers will request PD-L1 testing as a prerequisite for approving therapy with PD-1 inhibitors, or be happy to accept the ‘all-comers’ approached taken by BMS in its development programme for Opdivo.\nAnalysts at Morgan Stanley, Bernstein and Goldman have previously indicated that PD-L1 status should not be an issue, suggesting a big win for BMS versus Merck, although others have suggested that it will have an impact.\nThe opposing camp will point to data on Roche’s checkpoint inhibitor candidate atezolizumab (MPDL3280A) which specifically targets PD-L1 and reinforced the importance of PD-L1 expression measuring.\nIn the phase II POPLAR trial, reported at this year’s American Society of Clinical Oncology (ASCO) meeting, it was shown that PD-L1-negative patients fared worse than PD-L1-positive patients on atezolizumab, with the level of expression correlating with improvement in progression-free survival (PFS).\nThe data also suggested that PD-L1-negative patients had a shortened PFS compared to docetaxel. If that result was also shown in other studies it could have a bearing on the expected shift in usage of PD-1 inhibitors into the first-line NSCLC setting, as traditional chemotherapy may be preferred in some patients, at least until combination data with PD-1 inhibitors and chemo or other immuno-oncology drug such as CTLA4 inhibitors is available.\nDon't miss your daily pharmaphorum news.\nSUBSCRIBE free here.", "label": "Yes"}
{"text": "Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling\nApproximately 65% of B cells generated in human bone marrow are potentially harmful autoreactive B cells. Most of these cells are clonally deleted in the bone marrow, while those autoreactive B cells that escape to the periphery are anergized or perish before becoming mature B cells. Escape of self-reactive B cells from tolerance permits production of pathogenic auto-antibodies; recent studies suggest that extended B lymphocyte survival is a cause of autoimmune disease in mice and humans. Here we report a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKCdelta): spontaneous death of resting B cells is regulated by nuclear localization of PKCdelta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B). We show that treatment of B cells with the potent B-cell survival factor BAFF ('B-cell-activating factor belonging to the TNF family') prevents nuclear accumulation of PKCdelta. Our data suggest the existence of a previously unknown BAFF-induced and PKCdelta-mediated nuclear signalling pathway which regulates B-cell survival.\n|Authors||Mecklenbrauker, I.;Kalled, S. L.;Leitges, M.;Mackay, F.;Tarakhovsky, A. :|\n|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15361883|", "label": "Yes"}
{"text": "Next-generation DNA sequencing (NGS) is rapidly becoming an indispensable tool for genome-directed cancer diagnostics, but next-generation RNA sequencing (RNA-seq) is currently not standardly used in clinical diagnostics for expression assessment. However, multi-gene RNA diagnostic assays are used increasingly in the routine diagnosis of early stage breast cancer. Two of the most widely used tests are currently available only as a central laboratory service, which limits their clinical use.\nAgendia scientists evaluated the use of RNA-seq as a de-centralized methodology to perform such tests. The MammaPrint and BluePrint RNA-seq tests were found to be equivalent to the clinically validated microarray tests. The RNA-seq tests were highly reproducible when performed in different locations, stable over-time. The MammaPrint RNA-seq test was clinically validated. These data demonstrate that RNA-seq can be used as a de-centralized platform, yielding results substantially equivalent to results derived from the predicate diagnostic device.\nA: Expression heatmaps of the MammaPrint 70 genes measured with NGS (left panel) and microarray (right panel) in 204 matched NGS and microarray patient samples. Samples are ordered based on their microarray MammaPrint Index indicated as scatterplot graph next to the heatmap. Genes are clustered based on their NGS expression. B: Expression of the BluePrint 80 genes measured with NGS (left panel) and with microarray (right panel) in 204 matched NGS and microarray patient samples. Samples are ordered based on their microarray BluePrint subtype indicated as color bar next to the heatmap (Luminal-type, blue; HER2-type yellow, Basal-type, red). Genes are clustered based on their NGS expression. Samples are showed in rows, genes are showed in columns. Genes are clustered using Hierarchical Clustering, Pearson correlation distance, and average linkage. Data are normalized, Log2 transformed and median centered prior visualization. The color bar underneath the heatmap reports the expression range (from -3 to +3: 70 genes; from -5 to +5: 80 genes). NGS=Next-Generation Sequencing.", "label": "Yes"}
{"text": "Mahi-mahi: A large fish that lives in the open ocean in warm parts of the world.\nMammal: A warm-blooded animal that breathes air, has hair and feeds its young with milk.\nMainsail: Main or biggest sail on a sailing vessel.\nManagement: Process by which conservation is made possible.\nMangrove: A small tropical tree that grows in wetlands at the edge of the ocean. Mangrove forests are habitat for many kinds of fishes and other animals.\nManoeuvre: To control the movement and direction of something, as to manoeuvre a vehicle.\nMantle: A portion of the body wall of a mollusc. In snails, clams and other molluscs with shells, the mantle secretes the shell. In octopus and squid, the mantle is the outside of the body.\nMarine: Of the sea.\nMarine betta: A small, spotted fish found on coral reefs of the western Pacific.\nMarine snow: Organic particles that fall into the deep sea from the sunlit surface waters.\nMarine education: The process that teaches people about the cultural, recreational, environmental, commercial and management issues associated with the sea.\nMarine pest: Increase in population numbers of a animal or plant that attracts media attention.\nMarine Studies: A study of the cultural, environmental, commercial and recreational aspects of the sea and its management.\nMarine threat: Potential to carry pest organisms into our country.\nMaritime archaeology: Science of preserving ships and shipwrecks.\nMaritime museums: Places where marine culture is preserved for public admission.\nMARPOL: International convention that deals with marine pollution from ships.\nMarsh: A wetland where plants grow with their roots in water and their tops in the air.\nMarsh wren: A small songbird that nests in marshes.\nMask: In snorkelling, a covering for the face that helps you to see better underwater.\nMast: An upright spar that supports sails and associated rigging.\nMedusa: The umbrella-shaped type of jelly.\nMembrane filter: Filter used to catch bacteria to check faecal coliform levels when determining water quality.\nMercury: Liquid used in thermometers. Expands or contracts with changing temperature.\nMesoglea: The layer of gelatinous material that separates the inner and outer cell layers of a coelenterate.\nMesopelagic: The twilight midwater zone 660 to 3,300 feet deep (200 to 1,000 meters), between the upper sunlit zone and the dark ocean depths.\nMesotech sonar: A device on a remotely operated vehicle that's similar to an echo-sounder and shows the bathymetry (hills and valleys) of the seafloor.\nMeteorologist: Person who studies and forecasts the weather.\nMeter: A length of measurement equal to 100 centimetres. (39.37 inches, or approximately three feet)\nMethane: A colorless, odorless gas formed naturally by the decomposition of organic matter.\nMicroridge: Line of sand that is deposited as wave stops washing up the beach.\nMicroscope: Instrument used to see very small animals, plants and bacteria.\nMicroscopic: So small that it can only be seen with a microscope.\nMid-oceanic ridges: Elongated rises on the ocean floor where molten rock periodically erupts, forming new oceanic crust.\nMid-water: A habitat in the deep sea, usually defined as the waters between the sunlit surface and the deep seafloor.\nMigration: The periodic movement of animals from one place to another, often between feeding and spawning areas.\nMinamata disease: Crippling disorder of humans caused by mercury poisoning from contaminated seafood.\nMirdawarr: Aboriginal term for the end of the wet season.\nMole crab: A small crab that lives buried in sand at the ocean's edge; also called the sand crab. Mole crabs can dig very fast to escape from predators.\nMolt: To shed old feathers or hairs so that new ones can grow. Birds molt every year; so do elephant seals.\nModule: Part of a certificate course, also referred to as a course element.\nMonitor: (verb) to check or gather information. (noun1) A person who checks or gathers information. (noun2) A screen for viewing information, such as a computer monitor.\nMoon snail: A species of marine snail that has a large, pale, rounded shell.\nMooring: A fixed fastener or anchor used by boats. Boats using moorings donít have to use traditional anchors this reduces damage to coral reefs.\nMorphology: The scientific study of the form and structure of living organisms; or the form and structure itself.\nMoulting: In crustaceans, the process whereby outer shell is shed.\nMouthpiece: Forms part of the snorkel placed in the mouth.\nMudflat: A flat area along the coast, covered with a thick layer of mud or sand. Mudflats are usually under water at high tide.\nMultiskilled: Ability to do many tasks on a ship, e.g. drive a tender boat, perform first aid, launch a life raft, roll napkins.\nMulti-use areas: Areas in a marine park that can be used for different purposes by different groups of people.\nMulticulturalism: Term used to describe many cultures and learning to get on with one another with mutual respect.\nMussel: a mollusc similar to a clam but with narrow, dark-colored shells.\nMutualism: A form of symbiosis where both species involved benefit from the partnership.\nMysids: Group of small, shrimp-like crustaceans characterised by possessing a ventral brood pouch.", "label": "Yes"}
{"text": "Spray your evergreen tree with horticultural or dormant oil (3 to 4 percent) in the fall and spring when the spruce spider mites are active. These oils work by smothering the mites and their eggs on contact, so you must coat the entire tree for the spray to be effective.\nCan evergreens recover from spider mites?\nSpider mites can be very destructive to evergreens. Spruce and arborvitae are most susceptible to spider mites. The infested tree or shrub will require a topical or systemic treatment for control of mites.\nHow do you treat spider mites on evergreen trees?\nOne cheap and easy way to rid your conifer of spider mites is to just get the hose and spray the tree good and hard with water. This will wash away the adult mites but not the eggs. Spray your tree in this manner for at least four days in a row to get all the mites as they hatch out.\nWhat kills spider mites on trees?\nUse Insecticidal Soaps or Oils Horticultural oils are less likely than chemical pesticides to kill beneficial insects, and are thus regarded as organic products. For fruit trees, a mixture that combines horticultural soap with an oil is effective when applied every three to five days until the mites are killed.\nCan trees recover from spider mites?\nSpray Your Plants With Water Spraying the leaves and branches of your trees with a nozzle on your garden hose will dislodge the mites and wash them to the ground. They are not good climbers and will likely die on the ground. This is a quick, organic way to remove spider mites from your trees this winter.\nHow do you prevent spider mites on trees?\nPrevention and Maintenance\n- Make Sure You Have Them. Since spider mites are so small, you have to make sure that they’re the culprits for your plant problems.\n- Hose Them Down. Spider Mites like dry, dusty conditions.\n- Clean Up. Having debris around trees and plants make spider mites feel welcome.\n- Control Them.\nHow do you get rid of spider mites once and for all?\nRubbing alcohol: The rubbing alcohol you have around the house also can kill spider mites. Soak cotton balls in rubbing alcohol and wipe across the foliage of infested houseplants. Let either the dish soap or rubbing alcohol sit on the plants a few hours, and then rinse the leaves thoroughly with water.\nHow do you treat tree mites?\nUse a high-pressure hose or a hose attachment to thoroughly spray down an infested tree, making sure to get underneath the leaves as well. This will wash off mites and their eggs, plus get rid of the dusty conditions that contribute to outbreaks. Chemical control. Miticides are chemical substances used to kill mites.\nHow do I get rid of spider mites on my palm tree?\nHow To Get Rid Of Spider Mites On Palm Tree?\n- Getting rid of spider mites on palm trees involves spraying them with homemade soap solution, horticultural oil, or insecticidal soaps.\n- Prune and discard the leaves that are heavily infested.\n- Rub the remaining leaves with 70% rubbing alcohol to kill the remaining mites.\nHow do I get rid of spider mites outside?\nSpraying with a strong stream of water (particularly the undersides of leaves) will provide some control. Spray plants frequently to control future buildups. For severe infestations, affected plants or plant parts can be removed and destroyed. There are several natural predators that feed on spider mites.\nWhat do spider mites look like on a tree?\nThe mites feed by sucking the chlorophyll out of the leaves, causing little white dots called stipples. When the mites are present in large numbers, the leaves turn yellow or bronze and drop off. Silk webbing over the leaves and tender shoots is another indication that you have spider mites.\nHow do you get rid of spider webs in trees?\nHow to get rid of “spider webs” in trees. First, use a broom to remove webs from branches and improve the look of your trees. But, fall webworms live in cocoons in winter rather than their webs. So, even if you remove their webs, they can still return next summer.\nWhat is the best pesticide for spider mites?\nTOP-8 Spider Mite Killers\n- Garden Safe Brand Insecticidal Soap Insect Killer.\n- Safer Brand 5118-6 Insect Killing Soap Concentrate.\n- BioAdvanced 701290B Insecticide Fungicide Miticide 3-in-1.\n- Supreme Growers Smite Spider Mite Killer.\n- 1500 Live Ladybugs.\n- 2,000 Live Adult Predatory Mites.\n- Voluntary Purchasing Group 32034 EMW7309834.\nHow do you prevent spider mites?\nPreventing Spider Mites\n- Sterlise. Clean your room before every new crop cycle.\n- Take your Own Cuttings. Take your own cuttings when you can.\n- Use Insect Traps.\n- Check yourself!\n- Use Bug Blockers.\n- Inspect Often.\n- Use Predator Sachets (preventative)\nHow do you make spider mite spray?\nRosemary is a natural insecticide and using a concoction of rosemary oil and water will take care of your spider mite infestation. With a 2:1 ratio of water to rosemary oil, spray the oil spray onto the leaves of the plant to serve as a natural spider mite killer.", "label": "Yes"}
{"text": "Photo: Jumping Dolphin Sunset Scenery Pic\nAs though heralding the end of the day and celebrating a glorious sunset, this pic shows a Pacific White Sided dolphin jumping out of the water on a calm evening with beautiful Vancouver Island scenery in the background.\nMore photo information\nPic of a dolphin jumping out of the water at sunset with the Vancouver Island scenery in the background.\nPictures from photo gallery: \"Dolphin Pictures\"\nA playful Pacific White Sided Dolphin jumping out of the waters of Johnstone Strait, backdropped by mountainous scenery during sunset makes for a great photo pic.\nNorthern Vancouver Island is an area steeped in beautiful scenery and a variety of wildlife including numerous species of marine mammals such as sea lions, whales, and dolphins. Eagles and bears also make Northern Vancouver Island their home.\nPacific White Sided Dolphin at sunset in Johnstone Strait off Northern Vancouver Island, British Columbia, Canada.\nThis picture is part of the photo album \"Dolphin Pictures\" - there are more beautiful images waiting for you.\nTechnical Information for this photo:\nI photographed this photo with the digital SLR camera model Canon EOS-1Ds Mark II, aperture of f/6.3, exposure time of 1/800 sec. on ISO 200, as always I used a original Canon Lens, the focus lenght for this picture was 235mm.\nJumping Dolphin Sunset Scenery Pic\nRolf Hicker Photography\nQuicklinks to photo galleries \"pictures of...\"\nBack to top of photo page.", "label": "Yes"}
{"text": "Australorp Bantam – Everything You Need to Know\nAustralorp bantam chickens are a miniature version of Australorp chickens. Bantam Australorp chickens are very friendly, weigh between 2-3 pounds, and can lay 5-6 eggs a week. With good care and a proper diet, these chickens can live up to 10 years.\nFrom as early as 1000 CE, sailors would spend considerable time on the sea handling vessels or ocean combats. Unquestionably, these encounters played a significant role in introducing Bantam chickens to the world. The name was derived from a renowned seaport in Banten province, Indonesia.\nThe impressive story behind the Bantam chicken started when some sailors came across a tiny but beneficial local chicken within the seaport. Out of curiosity, they put them on board as a source of meat and for ornamental purposes.\nLater, the term Banten was coined into Bantam and registered as an English name. Today we will define why raising Austalorps bantam chickens is never a wrong decision.\nWhat is a Bantam Australorp Chicken?\nA bantam chicken is a miniature size version of a particular variety. Most regular-sized fowls have a bantam equivalent. In other terms, bantams are chickens that share similar traits with standard-sized species but are smaller in posture.\nWhen it comes to Bantam Austalorps, this refers to a miniature counterpart of the famous dual-purpose chicken breed from Australia. Records suggest that the Australorp bantams were first developed in England probably way before World War ll.\nThe brighter side is that they possess similar impressive qualities similar to regular Austalorps. This translates to a prolific production of meat and eggs. In addition, the petite birds have an admirable temperament that enables them to coexist peacefully with humans and other bird’s species.\nMost novice farmers assume that Bantams may receive the worst form of the pecking order due to their small size. It is worth pointing out that the species are pretty hardy and comfortably manage to find their way to the top.\nHowever, consider placing them with less aggressive species to prevent any ugly scenes. They also come in handy when it comes to insect control and the production of manure.\nBantam Australorp Chicken Characteristics\nBelow are vital characteristics of Austalorps bantam chickens.\n– Size and Weight\nBantam chicken breeds sizes differ from one bird to another. Mainly they weigh at least 1/2 or 2/3 of a regular chicken. A healthy adult rooster can weigh about 2 to 2.7 pounds. On the other hand, hens weigh slightly less at approximately 1.7 to 2.3 pounds.\nBear in mind that the petite size is ideal for farmers with limited space. In truth, you can keep two tiny Bantams in an area occupied by one standard size chicken. Still, you may have to feed them less food because of their small anatomy.\nThere is a higher chance that such an arrangement may bore many desirable results. After all, you may end up spending less money on chicken feed and habitat maintenance.\nRegardless of their size or plumage color, all Australorps are hardy creatures that withstand most fowl ailments. Moreover, rarely would you come across an Australorp bird with physical defects like twisted beaks. Often, it is never easy to pinpoint exact infections in poultry because there is a whole load of potential culprits.\nLuckily, most fowl diseases are treatable, which is crucial in prolonging your bird’s life. Common diseases you should be on the lookout for include Air suck disease, Coccidiosis, Bumblefoot, Botulism, Bronchitis, Fowl cholera, Fowl pox, New castle, and Marek disease.\nThe brighter side is that healthy Australorp Bantam can enjoy a long life of 6-10 years. To achieve this, ensure that the birds live in clean enclosures to minimize contamination.\nOne outstanding feature about Australorps is their docile and gentle disposition. Be wary that the birds can become excessively attached to their keepers.\nHowever, this nature enables them to live comfortably either in rural or urban settings. Above all, they are perfect around young children because of their meek and pleasant personalities.\n– Egg Laying\nSubject to nutrition and environment, your pullets may produce the first egg from 18 weeks. Unless you want to breed your birds, a rooster is not always needed in the process. Note that eggs produced without roosters are not fertilized and are only ideal for your kitchen recipes.\nAfter the first egg, the hens may produce tiny uneven eggs known as fart eggs. It might take a couple of weeks for the production to normalize. Altogether, your petite bird friends are excellent layers who can produce up to 300 eggs annually.\nAustralorp Bantam Rooster vs Hen\nDifferentiating between a bantam male and a female chick is never easy, especially to novice farmers. Nevertheless, when they grow bigger, roosters become physically bigger and develop distinctive narrow plumage.\nAlso, you may notice pointed tips on the feathers around the shoulders and necks. What is more, roosters have taller and more vibrant red combs. Additionally, roosters have more prominent wattles which hang loosely around the beaks.\nWhere to Buy Australorp Bantam Chickens?\nWith several fraud chicken breeders coming up, it is vital to buy your chicks from reliable sources. Still, you can tell a pure Australorp by its well-rounded body and featherless legs.\nThe birds also have an erect posture with the tail standing firm. Keep following as we define where to find the first-rate Bantam chickens for your backyard.\n– Certified Breeders\nThe fundamental objective of a chicken breeding program is to raise the standard of birds produced. It requires an expert to start and accomplish the task at hand while following the ethics given by the law. For this reason, only buy chicks from vetted breeders to increase the chance of raising prolific breeds.\n– Forums and Facebook Groups\nAn upsurge of digital platforms undeniably enables farmers to find reliable breeders using the latest technology. The beauty of technological advancement is the availability of instant reviews from previous customers. That way, you may not have to worry much about buying substandard species.\n– Local Hatcheries\nDependable chicken hatcheries incubate thousands of healthy eggs for the market. The advantage of this approach is that you are guaranteed nothing but high-quality chickens because of the top-notch production mechanisms used.\nThankfully, online presence makes it less complicated to contact the nearest hatchery in your area. With a touch of the dial, you can have healthy, robust chicks deliv delivered to your doorstep real fast.\nBreeding and raising Bantams can be a lucrative and fun business idea. You see, the tiny bids eat less and require minimal space.\nMost importantly, they are hardy and likely to survive life-threatening chicken ailments and are impressively productive.", "label": "Yes"}
{"text": "Flashcards in CVA Deck (36):\nWhat is a Cerebrovascular Disease? CVA\nDefine what a CVA is. What is it? What is it due to?\nan acute neurological deficit d/t ischemia\nIf a CVA is an acute neurological deficit d/t ischemia, what does this mean in regards to perfusion to the brain?\nLack of perfusion to the brain.\nThere are 2 Types of CVAs. Name them and explain what it is.\n1. Ischemic CVA\n- obstructed or occluded vessel causing lack of perfusion to the brain tissue\n2. Hemorrhagic CVA\n- vessel severed in cranium --> hemorrhage --> brain compression\nIschemic CVA: the vessel can be occluded why? (2)\nThe risks for CVA\n1. Modifiable (5)\n2. Unmodifiable (4)\n1. HTN, atherosclerosis, Hyperlipiedmia, DM, Smoking\n2. Aging, males, prior strokes, familial history\nIf the modifiable risk factors for CVA are managed, can a stroke be avoided?\nThe patho for CVA involves the brain being sensitive to what two things?\nCan the brain utilize anarerobic metabolism?\nOxygen and glucose\nThe brain relies on aerobic metabolism for ATP\nWhat are the two forms of stroke?\n1. Ischemic CVA\n2. Hemorrhagic CVA\nExplain the patho for Ischemic CVA:\nOcclusion of the vessel --> focal ischemia --> necrotic core (dead tissue which will have loss of function) --> pneumbra around the necrotic core (tissue that is lacking perfusion but still alive) --> penumbra will become smaller and necrotic core bigger if there is not an intervention to increase the blood supply to the brain\nWhat does focal ischemia mean?\nWhat does global ischemia mean?\n1 hemisphere affected\nMost of the brain is obstructed (BIG PROBLEM!)\n1. Explain the patho for Hemorrhagic CVA:\n2. What usually causes this? (4)\n3. What are the two complications from this?\n1. severed vessel --> hemorrhaging --> compression\n2. Htn and ageing (also aneurysms and tumors)\n3. Coma and death\nis this a large or mini stroke?\nTransient Ischemic Attack\nTransient Ischemic Attack: what is occuring to the neurological deficit? d/t what?\nacute, brief, neurological deficit d/t acute focal ischemia\n1. Is a TIA reversible?\n2. Is the ET/Patho of TIA similar to CVA?\n3. Does a TIA involve a necrotic core? Penumbra?\n3. No nectrotic core, yes penumbra\nWhy would a TIA have a pneumbra?\nThe tissue is not being properly perfused, but there is no necrosis occuring.\nDoes a TIA involve permanant damage?\nIf you have a TIA, what does this do for your risk of future TIA's or strokes?\nIncreases the risk\nThe manifestations for CVA depend on what?\nAre the mnfts an acute onset?\nthe location, size of vessel, and area of brain distal to the vessel\nYes they are an acute onset\nThe mnfts for a CVA in the left hempishere would present in the right side of a patient. Why?\nD/t to the decaustation of the pyramids, the fibers cross over.\nWhat are the 3 main symptoms of a CVA?\n1. Unilateral weakness or numbness in face, arm, and or leg (1 or more)\n2. Speech alteration\n3. Altered vision in 1 eye\nHow is CVA Dx (3)\n3. MRI/CT scans\nWhat labs are looked at for CVA? (3)\nCBC, INR, lipids\n1. Why assess the INR?\n2. Why assess the lipids?\n1. Clotting time (for TPA)\n2. Hyperlipedima can lead to atherosclerosis\nWhat is the electroencephogram looking at?\nConductivity of the brain tissue\nWhat is the MRI/CT scan looking for?\nDifferentiating between Ischemic and Hemorrhagic stroke\nThe treatment for strokes main focus is to preserve AND salvage what?\nWhat is the Stat treatment for Ischemic stroke.\nASA (antiplatelet) 160 mg, then taper down\nWhat is the purpose of administering the antiplatelet?\nNot allowing platelets to aggregate\nWhen would TPA be given to a patient?\nWhen they meet the criteria and it is an ischemic stroke.\nThe treatment for CV risk factors includes what? (2)\nstatins to decrease cholesterol\nantihypertensives to decrease BP\nSx for stenosis for patients with ischemic stroke. What is this procedure called? what is the time frame post stroke for it to be done?\nCarotid endoarterectomy done within 2 weeks of CVA\nWhat would the stenosis be?\nNarrowing of the blood vessel d/t atherosclerosis\nTo prevent recurrence involves what? (2)\nReducing risk factors\nBlood thinners to prevent thrombus reappearing\nWould a blood thinner ever be given to a patient experiencing a hemorrhagic stroke?\nNope you crazy lady.", "label": "Yes"}
{"text": "Chronic diseases or inflammatory processes in the liver can lead to fatty liver and destroy tissue in the process. Liver cells are then replaced by functionless connective tissue. The result: The liver can no longer or only partially perform their tasks in metabolism and detoxification. Such cirrhosis of the liver is irreversible and life threatening in the terminal stages. Cirrhosis affects more than twice as many men as women.\nCauses of cirrhosis\nAlmost every chronic liver disease can lead to liver cirrhosis. In about half of the cases chronic alcohol abuse is the cause. About one third of those affected are based on chronic viral hepatitis.\nRarer causes are, for example, autoimmune diseases in the area of the liver-located biliary tract, which lead to constant inflammatory reactions, and metabolic diseases such as Wilson's disease or hemochromatosis, in which copper or iron are stored in the liver and lead to cell death.\nCirrhosis: symptoms and consequences\nThe liver cirrhosis itself usually causes symptoms only relatively late; Depending on the first complaints of the underlying disease are in the foreground. The symptoms of cirrhosis of the liver result from the limited performance of the liver.\nThe main consequences are an altered protein and hormone balance, the accumulation of toxic substances such as ammonia in the blood, which also reach the brain and damage it (hepatic encephalopathy), as well as an increase in pressure in the portal vein. Since the blood is difficult to flow through the scarred shrinkage of the liver, it creates bypasses, which in turn can lead to life-threatening bleeding in the area of the esophagus. In addition, liver cirrhosis increases the risk of liver cancer.\nThe leading complications of liver cirrhosis include:\n- General symptoms: decreased performance, fatigue, weight loss\n- Skin abnormalities: vascular spider (Spider naevi), lacerated lips and tongue, reddened palms, white nails, vein extensions under the abdominal skin (signs of a bypass circulation)\n- Bleeding tendency, but also a coagulation tendency is possible\n- Ascites: distended abdomen, possibly with pressure and upper abdominal pain\n- Hormonal disorders: loss of libido, male breast and bald head baldness (loss of male hair on the abdomen), in women menstrual disorders\n- Jaundice (jaundice) with yellow discoloration of the skin and conjunctiva as well as severe itching\n- Signs of brain disorders: Disorientation, memory problems, mental retching or mood swings, inappropriate behavior, later impaired consciousness to unconsciousness (liver failure coma)\nDuring the examination, for example during palpation or ultrasound, the liver appears enlarged at the beginning as a result of the disease processes. If the cirrhosis of the liver progresses, the liver shrinks as a result of the scarring changes, and it becomes small, firm and tubercular.\nDiagnosis of cirrhosis\nIn order to diagnose liver cirrhosis, the typical symptoms and findings in the physical examination often suffice. Laboratory examinations, ultrasound and laparoscopy or liver biopsy are performed to look for causes, to assess the stage of cirrhosis and to plan the therapy.\nA gastroscopy is used to check whether or not there are potentially life-threatening circulatory circuits of the blood vessels known as esophageal varices on the esophagus.\nTherapy of cirrhosis\nOnce changed liver tissue can not be reconverted into functional liver cells. Therefore, the primary goal of the therapy is to reduce the progression of cirrhosis. First, therefore, is the treatment of the underlying disease. In addition, it is imperative to avoid substances that can further damage the liver - especially alcohol, but also drugs that are often detoxified via the liver. In addition, a diet adapted to liver cirrhosis makes sense.\nIn addition, the symptoms and possible complications of cirrhosis of the liver are treated. Thus, ascites is reduced by means of medication or abdominal puncture, or bleeding from esophageal spasm veins is stopped with a reflection. In some cases, a non-dangerous shunt operation is performed in which an artificial bypass of the portal vein system is created. This portosystemic shunt protects against varicose bleeding but increases the risk of liver coma.\nIn some cases liver function can be restored by liver transplantation. However, due to some exclusion criteria, such as alcohol dependence, many sufferers are out of the question.\nCirrhosis: course and life expectancy\nLife expectancy in cirrhosis depends firstly on the cause, on the other hand on how far the cirrhosis of the liver has progressed and how well it can prevent its exacerbation. If nothing is done or if, for example, the liver is further damaged by alcohol, the cirrhosis of the liver ends in death in months to a few years. The most frequent cause of death is bleeding from esophageal varicose veins, followed by hepatic coma and combined liver and kidney failure (hepatorenal syndrome).\nTo estimate the prognosis, doctors use the Child Pugh score. With its help, liver cirrhosis is divided into stages (Child 1 to Child 3). Relevant are five criteria (three laboratory values as well as the ascites and the severity of the brain disorders), for each of which a score of 1 to 3 is awarded. The higher the score achieved (maximum 15), the lower the life expectancy.", "label": "Yes"}
{"text": "Determination of the sizes of fundamental repetitive sequences for the identification of core elements. (A) The distribution of 16,872 repetitive sequences. Four small peaks at 3, 3.6, 4.1, and 6–8.1 kbp are indicated by arrows. (B) The minimal lengths of the extracted repetitive sequences are plotted against the coverage ratio as a red line. The maximum lengths of the repetitive sequences are plotted against the coverage ratio as a blue line. The red line shows that SD13M is covered almost completely (>96%) by the extracted repetitive sequences, and the broken red line shows that 94% of SD13M is covered by repetitive sequences larger than 3 kbp. The broken blue line shows that most of SD13M (>94%) is covered by repetitive sequences smaller than 4.5 kbp. (C) The minimum lengths of the regions shared when two repetitive sequences were aligned are plotted against the number of sequences in which such regions are shared. The broken red line shows that 92% of pairs share 2.7 kbp of consensus sequences, whereas the broken blue line shows that 14% of pairs share 4.5 kbp of consensus sequences.", "label": "Yes"}
{"text": "Best moveset for Yanmega\nThe green moves benefit from the Same Type Attack Bonus and deliver 20% more damage.\nYanmega is a huge, dark green dragonfly. Its enormous crimson eyes are framed by black lines that form a sideways “T” shape. Next to its little mouth, it bears two huge, white fangs or mandibles. Its massive jaw strength enables it to chomp enemies apart while flying at tremendous speeds. Yanmega’s segments each have a red spot, and the final tail segment has a black triangular plate. It has two plates like these on the rear of its thorax and a third on the top of its head. Yanmega has six tiny black legs. It has four white, round wings with crimson ends and two smaller white wings at the tip of its tail.\nBy flapping its wings, Yanmega may generate shock waves. These tremendous shock waves may cause catastrophic harm to the adversary. Yanmega’s wings are strong enough to transport an adult person. Yanmega is an uncommon species that may be found in woodland and marshy environments. It has a powerful jaw and can bite off the heads of its victims while flying at great speeds. Yanmega normally targets the prey’s weakest point, expending minimal energy in the process. Yanmega is reported to be an incredibly ferocious Pokémon, demanding a great deal of guts to tame this angry beetle.\nYanmega is part of a two-member family.", "label": "Yes"}
{"text": "Gardening club is continuing this term.\nWhat has been going on?\nSome of us were very shocked at how much had grown over the holidays!\nLast week we planted some sweetcorn and marrows for the greenhouse.\nSome of us worked in pairs to plant peas straight into the ground as the ground and weather are now warm enough for seeds to grow and hopefully survive.\nWe also transplanted some lettuce which we had grown from seed.\nWe are hoping that the Chopwell rabbits don't gobble them all up!\nThere was also much more weeding to be done.\nIt seems to be never ending but at least we will all have much stronger muscles at the end of it.\nThere will be opportunities to buy produce from the garden at the upcoming Sports Day and Summer Fayre - fingers crossed!\nWe desperately need to make some money to put in the gardening pot, so we hope you will support us!", "label": "Yes"}
{"text": "News & Updates\nSearch Research Content\nResource Finder at Kennedy Krieger Institute\nA free resource that provides access to information and support for individuals and families living with developmental disabilities.\nCirculating histones exacerbate inflammation in mice with acute liver failure.\n|Title||Circulating histones exacerbate inflammation in mice with acute liver failure.|\n|Publication Type||Journal Article|\n|Year of Publication||2013|\n|Authors||Wen Z, Liu Y, Li F, Ren F, Chen D, Li X, Wen T|\n|Journal||Journal of cellular biochemistry|\n|Date Published||2013 Oct|\nCirculating histones are a newly recognized mediator implicated in various inflammatory diseases. It is likely that the release of histones, from dying hepatocytes or inflammatory leukocytes, into the circulation initiates and amplifies inflammation during the course of acute liver failure (ALF). In this study, we investigated a putative pathogenic role of circulating histones in a murine model of ALF induced by D-galactosamine (GalN) plus lipopolysaccharide (LPS). Hepatic function and histological indexes, myeloperoxidase (MPO) activity, hepatocyte apoptosis and the levels of circulating histone were measured in GalN/LPS-treated mice. GalN/LPS caused severe liver damage and a notable increase in plasma concentration of circulating histones. To further assess the role of circulating histones in our model, we administered exogenous histones and anti-histone H4 antibody. Notably, exogenous histones aggravated GalN/LPS-induced hepatotoxicity, whereas anti-histone antibody significantly protected mice. Circulating histones may serve as both a functional marker of ALF activity and as an inflammatory mediator contributing to the progression of ALF. Blockade of circulating histones shows potent protective effects, suggesting a potential therapeutic strategy for ALF.\n|Alternate Journal||J. Cell. Biochem.|", "label": "Yes"}
{"text": "2Joint Russian-French Research Laboratory LIA1066, Russia, France\n3Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia\n4Institute Gustave Roussy, 39 rue Camille-Desmoulins, 94805 Villejuif, France; fax: +33(0)142-115494\n* To whom correspondence should be addressed.\nReceived May 8, 2014\nThe α- and β-globin gene domains are a traditional model for study of the domain organization of the eucaryotic genome because these genes encode hemoglobin, a physiologically important protein. The α-globin and β-globin gene domains are organized in completely different ways, while the expression of globin genes is tightly coordinated, which makes it extremely interesting to study the origin of these genes and the evolution of their regulatory systems. In this review, the organization of the α- and β-globin gene domains and their genomic environment in different taxonomic groups are comparatively analyzed. A new hypothesis of possible evolutionary pathways for segregated α- and β-globin gene domains of warm-blooded animals is proposed.\nKEY WORDS: α- and β-globin gene domains, gene expression, evolution", "label": "Yes"}
{"text": ". Mosquito's saliva is the main fundamental elements in the acquisition of human blood by mosquito, mosquito's saliva inhibit blood hemostatic response, the influx of saliva also may stimulate the mechanism for effector formation of the host, also in this process we may find some microorganism transmission. By knowing on how the components of mosquito's saliva process in stimulating our immune system, we could ensure the mechanism for pathogens and emerging diseases in our body. Flow Cytometry method used for detecting whether increased concentration of the saliva gland extract (SGE) affecting the proliferation and development of dendritic cells from bone marrow or not, while for the effect of SGE on lymphocytes is using colorimetric test. The concentration response curve was made to see the effect of SGE on Ae. aegypti cells (DC) and lymphocytes. The proliferation of DC from bone marrow precursor, its development and its function were not directly influenced by SGE of Ae. aegypti (concentration of 2.5 to 40μg/mL). While the results of SGE effects on lymphocytes showed that lymphocytes are extremely sensitive to saliva components. Based on the data, it was concluded that lymphocytes are potential to be a target for the main components of Ae. aegypti saliva compared to its dendritic cells.", "label": "Yes"}
{"text": "Alloy Therapeutics, a biotechnology ecosystem company, is proud to announce a new collaboration with Lundbeck, a global pharmaceutical powerhouse specializing in brain diseases. Together, they seek to discover novel biologics therapies that could revolutionize the way we treat brain diseases. With the combined expertise of both companies, they are confident they can make a real difference in the lives of those living with these illnesses.\nLundbeck has forged an alliance with Alloy to gain access to its innovative Antibody Discovery Services and SeqImmune™ discovery module – a sequence-first workflow for quickly and efficiently capturing early repertoires and creating maximum initial diversity.\nSince 2020, Lundbeck and Alloy have been deepening their relationship through the licensing of Alloy’s ATX-Gx™ humanized transgenic mouse platform, providing Lundbeck with complementary capabilities to enhance its biologics discovery efforts. Together, the two companies are striving to make groundbreaking advancements in the field.\nWe are thrilled to partner with Alloy to bring our internal scientific expertise to the forefront of biologics discovery. Alloy’s innovative mindset and dedication to the success of its partners has left us impressed, and we look forward to combining our capabilities to create inspiring results.\nIn 2017, Alloy set out to revolutionize the way pre-competitive biologics discovery technologies and expertise are accessed, with the aim of making it easier for the global scientific community to develop better medicines together. Their ATX-Gx platform was the first step in this mission, and was soon followed by the launch of the Antibody Discovery Service, providing scientists with a comprehensive solution for outsourcing their biologics discovery needs.\nAt Alloy, we are dedicated to helping our partners find the best possible therapeutic antibodies for their target and providing them with a comprehensive data package to ensure optimal results.\nTo make the process even more successful, we offer additional value-add services such as machine-learning-driven affinity maturation and optimization, bispecific engineering, translational medicine, and advanced antibody production. With our Antibody Discovery Service, you can be sure that you are getting the best antibodies for your target.\nAlloy is passionate about pushing the boundaries of innovation and is committed to reinvesting 100 percent of its revenue back into fueling progress. By doing so, they are constantly innovating and upgrading the technologies used in their discovery campaigns, making them more efficient and reliable than ever before.\nBiotherapeutic Discovery at Lundbeck is devoted to restoring the brain to its optimal state. Our cutting-edge research is centred around finding antibodies and biologics that can treat brain diseases effectively. We understand the delicate nature of the brain, which is why we demand only the highest quality drug lead candidates to meet our rigorous standards.\nTheATX-Gx platform, equipped with SeqImmune’s discovery module, holds the promise of uncovering highly diverse antibody repertoires, which is essential for finding the few potential drug leads. According to Allan Jensen, Vice President Biotherapeutic Discovery at Lundbeck, this capability is key for successful drug development.\nOur partnership with Lundbeck is a testament to our commitment to supporting the global scientific community in their efforts to create the most effective treatments for patients. We are honored that Lundbeck has placed their trust in us and chosen to expand our collaboration by utilizing our SeqImmune antibody discovery workflow. We are proud to have been working with Lundbeck for years to develop our platform technology.\nAbout Alloy Therapeutics\nAt Alloy Therapeutics, we’re committed to revolutionizing the global scientific community’s ability to make medicines that make a difference. We bring together a diverse network of academic, biotech, and pharmaceutical partners to provide access to pre-competitive resources and technologies.\nOur unique Innovation Subscriptions give partners access to all current and future innovations for a flat annual fee. We reinvest 100% of our revenue in innovation and access to innovation, so everyone can benefit from the latest breakthroughs. Join us on our mission to make a lasting impact in the field of biotechnology.\nAbout H. Lundbeck A/S\nFor over seven decades, H. Lundbeck A/S (LUN.CO, LUN DC, HLUYY) has been a leader in neuroscience research and solutions for brain diseases. We are passionate about restoring brain health for everyone, so that everyone can achieve their best. Our commitment to this cause is unwavering, and we strive to make a positive impact on the lives of people living with brain diseases all over the world.\nAt NeuroScience, we strive to create a world without stigma or discrimination against those living with brain diseases. We are dedicated to discovering and developing treatments to help make a positive impact on brain health conditions.\nOur research teams are tackling some of the most challenging issues in neuroscience, while our production facilities in Denmark, France, and Italy are working to bring forward transformative treatments. With research facilities in both Denmark and the United States, we are committed to making a difference for those living with a brain disease.", "label": "Yes"}
{"text": "Linking Spatial and Temporal Scales in Paleoecology and Ecology\nAndrew S. Cohen, Department of Geosciences, University of Arizona, Tucson, Arizona\nJames Brown, Department of Biology, University of New Mexico, Albuquerque, New Mexico\nDale Springer, Department of Geography and Earth Science, University of Bloomburg, Bloomburg, Pennsylvania\nPeter Holterhoff, Houston, Texas\nThe GSA Penrose Conference , \"Linking Spatial and Temporal Scales in Paleoecology and Ecology,\" was held in Solomons, Maryland, May 1418, 1998. This conference was cosponsored by the Paleontological Society and the Ecological Society of America. It brought together 76 paleoecologists and ecologists from eight countries to consider how ecological interpretation and synthesis are affected by the spatial and temporal scale at which data are collected and models are constructed. This conference provided an exciting venue for members of the earth and biological sciences communities to look for common scientific ground, and to identify interdisciplinary research directions that will cross the traditional boundaries between the fields of paleontology and ecology. Owing to the diverse background of the participants, the conveners organized the meeting around a series of activities intended to maximize cross-disciplinary interaction. Field trips, dedicated poster sessions, and panel discussions were emphasized throughout the meeting, whereas formal talks were used primarily to introduce general topics and provide fodder for conversation.\nThe first day of the conference was an all-day field trip examining the Virginia Coastal Reserve-Long Term Ecological Research Site (LTER), located along the barrier islands, coastal marshes and beaches of eastern Virginia, on the Delmarva Peninsula. This trip was organized by Bruce Hayden, and run by John Porter, Ray Dueser, Aaron Mills, Linda Blum, Bob Christian, and Michael Fenster. The premeeting field trip served to introduce the themes of the conference, through an understanding of the evolution of the coastal ecosystem of Virginia at varying temporal and spatial scales, and through discussion of how physical processes (tectonism, eustasy, and sediment supply) interact with ecosystem development at varying scales. The formation of an Eocene impact crater, centered on what is now southern Chesapeake Bay, set the stage for subsequent ecological events, whose effects are still being felt today. A combination of long-term relative subsidence in the southern Delmarva Peninsula associated with crater-induced structures, along with both low sediment supply and eustatic sea-level rise, is creating a rapid modern relative sea-level rise of ~3mm/yr along this coast. A primary function of the Virginia Coastal LTER is to monitor the effect of this sea-level rise, as it induces forest die-backs, transgressive salt marsh migration, and the formation of new storm flooding surfaces in what were previously forested coastal regions. Field trip participants also saw how human-induced change (changing agricultural methods and conversion of economic bases) is playing out in the context of this environmental change. In the afternoon, the field trip moved south, across the Chesapeake Bay Bridge to Cape Henry. Here, less than 50 km south of the LTER sites, a progradational Holocene coastline is developing, under the combined influence of considerably greater sediment input and lower subsidence rates. Formation of a succession of shoreward-migrating beach ridges has sequentially caused the development of bald cypress swamps in the swales between ridges. Changes in the scale and rate of landscape evolution during beach migration has caused vegetational zones to also migrate at varying rates.\nDay two of the conference marked the beginning of the formal sessions. Convener Andy Cohen introduced the background and themes of the conference. Ecological processes occur over a vast range of spatial and temporal scales, and it is increasingly evident that our perception of how these processes and changes play out is dependent on the scales at which we observe them, as well as our scientific and cultural differences. \"Deep Time\" (i.e., pre-Quaternary) paleoecologists, Quaternary paleoecologists, and neoecologists collect observations and generate theory at variable scales and with variable information bases. Can these observations be synthesized by common methodology and theory, or are there fundamental discontinuities crossing between scales? The morning's speakers confronted these issues through introductions to the various approaches to ecological understanding employed today. Mike Rosenzweig gave an introduction to large-scale ecological patterns and our current understanding of what these patterns signify in terms of dynamics at the regional and global level. Advances in statistical methods have greatly improved our ability to assess patterns of diversity in biotas, particularly with regard to species that are relatively rare. Convener Jim Brown presented a series of neoecological data sets gleaned from a variety of temporal and spatial scales, in an attempt to clarify for the paleoecologists in the audience the complexities in understanding pattern and its mechanistic interpretation. Richard Bambach gave participants an overview of the fossil record. He framed this discussion around a dichotomy of those processes and patterns that are familiar to both paleoecologists and neoecologists, and those that are only evident from the vantage point of long time intervals that paleoecologists can observe. Karl Flessa attacked the thorny question of temporal resolution in the fossil record. Paleoecology is only recently moving away from a long interlude of hand wringing over the problems taphonomy and time averaging of fossil faunas pose for paleoecology, to a realization that the fossil record can be resolved much better than traditionally thought and that time averaging isn't all bad news. Roy Plotnick discussed the roles of models and modeling in paleoecology, considering their potential for providing linkages between scales. He also showed the importance of a solid grounding in biological understanding in which to embed the development of theory, and the misinterpretations that may await modelers who don't have this grounding.\nPoster presentations that followed the morning talks emphasized the general theme of data acquisition in paleoecology and ecology. Posters provided an opportunity for participants to better understand the nature of data sets from fields in which they may have had little prior experience, as well as seeing how such data are manipulated statistically by other fields. Posters emphasized a wide variety of ecological subjects, including patterns of diversity or community structure data at varying scales, taphonomic effects of scaling interpretations, and body-size dynamics at varying scales and their relationship to evolution and climate. Two panel discussions were convened following each of the poster sessions of the day. Panel discussions allowed a different group of participants than those who had just spoken or presented posters to comment on what had been presented and to field questions from the general audience. This activity, which continued throughout the meeting, proved a highly successful and stimulating way to generate excitement about what had been covered up to that point. There was a buzz in the air following the first day's panel sessions, as participants recognized the great potential for cross-disciplinary research efforts that might arise by linking the perspectives of paleoecologists and ecologists around common research questions. For example, participants pondered how analogous time and space really are in ecology, whether time averaging is really a problem or, in fact an opportunity, what other types of issues besides diversity we should be considering in terms of temporal and spatial scaling, and at what conceptual levels paleoecology and ecology might interact. That evening, Jim Reichman from the National Center for Ecological Analysis and Synthesis (NCEAS) gave an after-dinner talk on how his center works, and its eagerness to entertain innovative proposals for sabbatical visits and collaborative workshops spanning the boundary between paleoecology and ecology.\nOn the third day, the conference moved to a detailed discussion of community structure and stability. Participants got down to considering major and contentious issues concerning the dynamics of diversity change and community structure over varying time and space scales. Linda Ivany and Carl Brett presented their case for coordinated stasis in the fossil record. This idea postulates that large assemblages of marine benthic organisms evolve at about the same time, co-occur over millions of years, and then simultaneously undergo extinction. Ivany reviewed evidence from the Devonian of New York and the Eocene of the U.S. Gulf Coast that suggests that benthic assemblages persisted over 18 Ma time intervals, even in the face of sea-level fluctuations. Mark Patzkowsky argued against the coordinated stasis model based on his work on similar Paleozoic ecosystems. In the Ordovician of the eastern United States he finds that species turnover largely corresponds to pulses of environmental change, and that significant extinction and origination events are not always simultaneous. Background turnover within stratigraphic units seems to be much higher than what has been reported by Brett, Ivany, and others. These divergent views lead to the question of how common patterns of individualistic vs. coordinated change really are, and to what extent our perception of these patterns are regulated by the temporal resolution of individual data sets and the episodicity of environmental change. Russ Graham and Steve Jackson both made a case for individualistic responses in explaining community composition in the Quaternary, in particular the occurrence of \"no modern analog\" biotas. Graham argued for using the Quaternary as a bridge between the deep paleoecological record and modern ecology. He noted that in the Quaternary, temporal resolution is now good enough that although he can't say that two individuals of co-occurring \"no-analog\" species saw each other \"eyeball to eyeball,\" they can be linked within 50 years in time. Both Graham and Jackson emphasized that patterns of individualistic change should not be confused with a notion of random association. Jackson argued for a greater understanding of potential yet unrealized niche space in organisms that may well explain these \"anomalous\" communities. Fred Grassle gave the conferees a fascinating glimpse into the species diversity and community composition in the deep sea. Although our understanding of this environment is limited by the difficulties involved in obtaining broad spatial and temporal coverage, it is evident that deep-sea organisms are highly diverse and their distributions very patchy. Even small-scale environmental heterogeneities, such as the deposition of a log, can create habitat patches with distinctive characteristics that persist for many years.\nAfternoon posters and panel sessions and the evening lecture continued exploring the themes of structure and stability, with greater attention to details of changes across scale boundaries. Questions tackled included: (1) Do \"rules\" exist in ecology, either within scales or transcending scale boundaries? (2) How analogous are time and space in ecology? (3) How does scaling affect our understanding of other issues such as body size structure in communities? (4) To what extent do terminological differences impede understanding between ecologists and paleoecologists? This point was illustrated by Joan Roughgarden in a discussion of the meaning of \"stability.\" Jack Sepkoski discussed patterns of global marine biotic organization, building on his earlier compilation analyses of Phanerozoic diversity patterns. He presented the problems of decomposing Phanerozoic marine diversity as a \"chicken or egg\" problem. Are the dominant controls at the local or regional level building up to creating a global pattern, or are there global controls on diversity that filter down to the local level? Both panel discussions and informal conversations on this day and the next day generated a lively discussion of specific research questions that might be usefully pursued by small working groups as followups to the conference, and the general excitement level surrounding this discussion led many to view the Penrose conference as but the first step in what could become an ongoing dialog among ecologists and paleoecologists with similar research question interests. There was considerable discussion of how working groups might continue the dialog through a series of NCEAS-type workshops.\nA field trip on the fourth day to the well-known Miocene Calvert Cliffs, led by Patricia Kelley and Susan Kidwell, provided an opportunity for the participants to consider, on the outcrop, many of the scaling, data collection, and taphonomic issues confronting paleo-ecologists that had been discussed over the last few days. Kidwell and Kelley gave detailed talks on the depositional setting of the marginal marine and shelf outcrops visited, the taphonomic context of the fossils (which varies in significant ways related to sea-level fluctuations along the Atlantic coastal margin), and the paleoecological problems currently or previously under study. The Miocene deposits of this region have been the focus of intensive investigations on the interface between ecology and evolution, most notably concerning processes of predator-prey interactions over time, and the tempo and mode of evolutionary change. Ecologists attending the meeting with little prior paleo-ecological experience gained a great deal of insight into the practical considerations of sampling.\nAn evening lecture on the fourth day by Mark Westoby looked at ecomorphic classification schemes for plants and plant communities. Westoby put forward a new classification scheme which characterizes various aspects of total leaf size, plant height, and seed size. The expression of all of these features involves fundamental ecological compromises across environmental gradients of moisture and nutrient availability. Some, though probably not all of these variables, could in principle be measured for fossil plants, thereby extending the comparative value of Westoby's scheme from strictly between floras or regions to cross time periods.\nOn the final day of the conference the theme of relationships between scales was more thoroughly explored. Joan Roughgarden looked at the evidence for linkage across scales in the recruitment and growth of intertidal barnacle communities. She demonstrated that local or patch scales of benthic intertidal adult barnacle and starfish interactions are strongly mediated by the vastly different scale over which planktonic barnacle larvae are dispersed and subsequently recruited to the benthos as adults. The latter results from oceanic current circulation and migration of Ekman transport systems with respect to the coastline. David Jablonski looked at the evolution of onshore to offshore trends in the origination of major benthic invertebrate biotas. He asked what upward or downward effects may influence this pattern. After showing that these patterns are not artifactual, resulting from taphonomic biases, he proceded to demonstrate that the dynamics of invasion at the higher, ordinal level differ in substantive ways from what is observed at lower hierarchical levels. Bill DiMichele discussed some of the scaling problems involved in understanding the evolution of terrestrial floras. Ecomorphic exploration of plant form and habitat preference on the broadest levels are strongly linked to phylogeny in plants. Although turnover may occur at lower taxonomic scales during the evolution of a flora, the fundamental character of a plant community with respect to more inclusive clades remains remarkably stable over long geologic time intervals. Community assembly \"rules\" may change through the history of a clade, and incumbency limits the degree to which new floras can invade an ecosystem. Arnie Miller reviewed the nature of the global Ordovician radiation of marine invertebrates, moving from global down to regional scales. Miller showed that an apparent global diversification event, when dissected into its component parts, is actually a composite of regions with highly variable rates of diversification, possibly driven by profound differences in tectonic setting of the various continents. This examination of processes at progressively smaller scales suggests a need to evaluate, in similar detail, the tempo of other presumptively global events such as mass extinctions. Bruce Patterson gave the final talk of the meeting, looking at altitudinal diversity gradients across the Peruvian Amazon. Although data from bird surveys have come to be a sort of benchmark against which biogeographic models are compared, Patterson showed that many other patterns of diversity occur, particularly among small mammals. Spatial ranges and gradients in extant organisms display many properties analogous to the biostratigraphic ranges familiar to paleoecologists. Using his nested subset methodology, Patterson argued that historical factors and differences in dispersal ability, as well as species-area relationships, play a role in structuring mammal distribution patterns.\nDuring the final panel discussion, a consensus arose among the panelists and audience as to the need for continued dialog among paleoecologists and ecologists. Scientists from both disciplines were urged to seek out colleagues with complementary skills to solve scaling problems of mutual interest while simultaneously drawing on the strengths of their respective knowledge. Following on the favored metaphor of the meeting, one conferee suggested that \"we had to become polygamous\" in developing collaborations among multiple fields. During the conference, participants had made tentative but important steps in learning each others' scientific \"languages,\" critical for sustained dialog. It was widely agreed that the need for such a dialog has never been greater. The combined issues of global change and biodiversity loss on Earth both dramatize the need for understanding processes of diversification, invasion, and extinction at all scales. Our old modus operandi, of making simplistic interpretations of data gleaned from each other's fields, should be replaced by truly collaborative efforts to understand these most serious of environmental problems. This Penrose Conference provided an exciting opportunity for all participants to begin what we hope will become a sustained and fruitful conversation between paleoecology and ecology.\nPenrose Conference Participants\nJ. Bret Bennington\nG. -Lynn Brewster-Wingard\n| Susan Kidwell\nChristopher G. Maples\nBrian A. Maurer\n| Roy Plotnick", "label": "Yes"}
{"text": "Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection\n1 Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA\n2 Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA\nBMC Infectious Diseases 2010, 10:10 doi:10.1186/1471-2334-10-10Published: 18 January 2010\nIt has been shown previously that administration of Francisella tularensis (Ft) Live Vaccine Strain (LVS) lipopolysaccharide (LPS) protects mice against subsequent challenge with Ft LVS and blunts the pro-inflammatory cytokine response.\nTo further investigate the molecular mechanisms that underlie Ft LVS LPS-mediated protection, we profiled global hepatic gene expression following Ft LVS LPS or saline pre-treatment and subsequent Ft LVS challenge using Affymetrix arrays.\nA large number of genes (> 3,000) were differentially expressed at 48 hours post-infection. The degree of modulation of inflammatory genes by infection was clearly attenuated by pre-treatment with Ft LVS LPS in the surviving mice. However, Ft LVS LPS alone had a subtle effect on the gene expression profile of the uninfected mice. By employing gene set enrichment analysis, we discovered significant up-regulation of the fatty acid metabolism pathway, which is regulated by peroxisome proliferator activated receptors (PPARs).\nWe hypothesize that the LPS-induced blunting of pro-inflammatory response in mouse is, in part, mediated by PPARs (α and γ).", "label": "Yes"}
{"text": "One of my young kin posted in effbee recently about the new Godzilla movie and how excited he was about it, sharing a picture from it. In the picture, Godzilla was HUGE. I mean, way bigger than ships and stuff. (Here's a link to the Wikipedia page, where you can see a poster picture, and see it compared to the Golden Gate Bridge.)\nNow I know I'm totally the wrong demographic for this, but I have to admit that when I saw the poster I immediately thought: how the heck did it get to be that big and no one noticed?\nHere's the thing: big animals need to eat a lot. A LOT.\nThere are basically three choices for eating a lot: plants. You do the elephant thing, and you eat plants, a lot of plants. Fortunately, there are lots of plants to eat, at least in some places. (And in the sea, there's algae, which grows fast. But, my understanding is that most algae grows only in relatively shallow areas (or is the free floating kind, which I'll count as plankton for now), so you'd think people would notice a giant lizard thing eating algae off the coast of Humboldt County, wouldn't you?\nplankton. This works GREAT for the big baleen whales. There's lots of it, which is good because whales need to eat a lot.\nThe problem for godzilla eating these things is that really, no one would be scared of a giant manatee godzilla thing, because it would be busy eating plants all the time. Yes, hippos are really dangerous, and you shouldn't swim with them, but they're not going to take out big ships very easily. And whales can be, I suppose, really dangerous around small boats, but not against the navy.\nAnd finally, most plant and plankton eaters don't look fierce and scary, right?\nThat leaves us with an animal that eats largish animals. But there's simply no largish animal for something the size of Godzilla (in that poster) to eat and get enough. Compared to a Godzilla that size, a whale is like me eating a minnow, not an entirely satisfying meal. And it's a whole lot easier to catch and eat a messful of minnows (or other smallish fish) than whales.\nIt's worth noting that many of the largest predators around these days are actually smaller than most of their prey, no? I mean, Brown Bears are bigger than salmon, but lions are smaller than wildebeasts. You either have to eat a whole lot of smaller stuffs (salmon, say, or plankton), or have a plentiful supply of bigger stuffs that you can somehow eat (wildebeasts for lions). Even so, hunting big stuff seems to work best cooperatively. Otherwise, it's handy to be bigger than what you want to eat. (That's why I should hunt minnows.)\nThus, a Godzilla that would find the TransAmerican Pyramid barely up to its chest is a Godzilla that would have deep unmet dietary needs. No wonder it's pissed off!\nLet's just admit that I wasn't nearly as impressed by the movie poster as my young kin.\nIf I remember correctly, Godzilla has a nuclear reactor for a heart. So I'm not sure he has to eat anything. But in the early movies, one of the signs that he's on the move is the mysterious disappearance of all the fish in an area of the ocean--all of them.ReplyDelete", "label": "Yes"}
{"text": "There are many causes for muscle twitching. Some of the common ones are stress and anxiety, too much caffeine, nutritional deficiency\n. smoking, alcohol and certain drugs like steroids\nand stimulants containing amphetamine\n. Rarer but more serious causes are a group of muscular deficiencies.\nSince you have been having this for a while, it makes sense to have a blood work up including thyroid\nlevels and a neurological examination.\nMeanwhile, certain things you could do are eat a healthier diet containing fruits and vegetables, avoid caffeinated foodstuffs and coffee, stop smoking if you do and reduce alcohol consumption, prevent dehydration\nand increase potassium intake commonly found in bananas, substitute drugs containing amphetamine after consulting with your prescribing doctor and lastly, reduce or find ways to avoid stress.", "label": "Yes"}
{"text": "Objectives: To analyze communication routes between perilymph spaces and the modiolus in the human cochlea. Such pathways are of potential importance with regard to local inner ear drug delivery and pharmacokinetics.\nDesign: We analyzed the surface structure of the human cochlea, using high-resolution scanning electron microscopy (SEM) in macerated and freshly obtained specimens together with light microscopy of celloidin-embedded temporal bones.\nResults: Combined SEM and light microscopy showed that perilymph and fluid spaces in the modiolar periphery form a common system. The modiolar wall of the scala vestibuli and tympani in the first and second turn is porous, forming a perilymphatic communication route to the perivascular and perineural spaces in the modiolus. A \"perimodiolar lymph\" or fluid space can be identified in the modiolar periphery. It communicates through a trabecular meshwork of porous membrane and web of connective tissue with the perilymph. The thin mesothelial cell sheets showed pores and displayed signs of vesicular activity.\nConclusions: This canalicular system may play a role in the circulation of perilymph in the human cochlea. We suggest that this system may represent an important fluid communication route between modiolus and perilymph and may represent a pathway for future drug and cell-based therapy to the inner ear.", "label": "Yes"}
{"text": "It is said that eating healthy foods and maintaining a balanced diet is the key to one’s well-being. Similarly, when treating erectile dysfunction (ED) in males, healthcare professionals often suggest their patients eat a healthy diet, be it breakfast, lunch, or dinner.\nBreakfast is the most important dietary food people take in the morning to enhance one’s physical energy and cognitive and psychological ability. Often, doctors recommend their male patients with erectile dysfunction to eat healthy breakfast which can also help improve the condition in such males. You might be thinking, what will be on the list of best breakfasts for erectile dysfunction? Don’t worry, we have listed all of the best choices of foods and beverages for breakfast that one can take to improve erectile dysfunction and boost one’s sex drive.\nWhat is Erectile Dysfunction?\nErectile Dysfunction (ED), also known as “impotence”, is a medical term used for males who are unable to achieve and maintain a penile erection before and during sexual intercourse with a partner/spouse.\nAt least one in seven males experience this type of sexual dysfunction that may occur during any stage of one’s life. Furthermore, sexual dysfunction or sexual deficit also includes associated problems like premature ejaculation (orgasm), low sperm count (sperm viscosity), reduced sexual desire (libido) due to low testosterone (men’s natural sexual hormone) level, lack of stamina and other factors.\nThus, ED is a health condition in which men may often have to deal with various problems such as anxiety, hypertension, embarrassment, stress, etc., as a result of unsatisfactory sexual activity with a partner/spouse.\nHow Does ED Affect Sex Drive in Men?\nMost males experience the inability to copulate with their partner/spouse which also makes such men feel embarrassed at times. Now, there can be several reasons that affect a few males as well as their sexual life and relationship with their partner/spouse.\nThe main factors that are known to cause ED in males include:\n- Lack of physical activity\n- Improper diet\n- Excess body weight\n- Other medical conditions like type-2 diabetes or cardiovascular disease etc.\n- Side effects from prolonged use of medications\n- Habitual smoking and drinking of alcohol, and addiction to illicit drugs\n- Contraction from sexually transmitted diseases and infections\n- These and other associated factors have a significant effect on the person’s sexual life.\n- A doctor may suggest men with ED take foods that can be beneficial in combating the condition.\nIs Eating Healthy Food Good for Treating Sexual Disorder?\nMen who experience conditions like erectile dysfunction (impotence), premature ejaculation, low testosterone level, low semen viscosity, etc., may have difficulty copulating with their partner/spouse which often results in unsatisfying intercourse. Though prescription medications can help with the condition, they also come with side effects after prolonged use of such medicines.\nFoods, however, are a natural remedy to treat many health problems, including sexual deficits in males, and enhance their stamina and sexual desire. Foods contain several essential properties that are needed for our body to function normally, besides growth and maintaining a healthy lifestyle. You should eat the foods that kill erectile dysfunction, or add them to your daily eating lifestyle for a great change.\nFor example, foods that are rich in zinc can help boost testosterone production, stimulate libido, and enhance erection quality. Zinc also delays ejaculation without any adverse effect on sexual stamina, libido, and other factors. It is present in several natural foods, such as oysters, beans, shrimp, beef, spinach, garlic, watermelon, mushrooms, nuts, etc.\nZinc can aid in boosting testosterone production while also optimizing performance during the sex drive. It is also important to note that zinc improves endurance, thus enhancing performance, whether it is sports or sexual activity. If there is any problem with taking Zinc in a natural way to boost testosterone then, you can choose some of the best testosterone boosters for erectile dysfunction.\nVarious medical research and studies show that eating specific foods may significantly aid in the treatment of erectile dysfunction in males.\nInclude These Foods & Beverages in Your Breakfast to Boost Sex Drive\nAside from taking medication drugs for treating ED, you can also naturally boost your sex drive by including foods and beverages in your breakfast routine.\nThe following is a list of a few breakfast choices that you can take to enhance your libido and lasting sex drive.\nGreen leafy salads and vegetables contain essential nutrients, vitamins, proteins, minerals, etc., that can be beneficial for one’s health and well-being.\nFor instance, carrots are rich in vitamin E offer plenty of health benefits, and are known to improve eyesight. Carrots are also helpful in treating premature ejaculation, increasing libido, and more.\nOther choices to include in your breakfast include spinach, lettuce, and arugula. The green leafy spinach is rich in magnesium and when included in your diet, it enhances your physical health and also boosts your sexual stamina.\nSpinach is also rich in folate which helps improve the blood flow and is essential for cell growth and reproduction. A low level of folic acid in the blood is associated with premature ejaculation. Since folate or folic acid is rich in vitamin B, it is very important in improving sexual health.\nAsparagus is an edible plant, particularly its root and stem, and is known to have a positive effect on sexual activity and reproduction. Consuming asparagus, especially with milk can significantly increase penile erection and improve premature ejaculation.\nTo gain sexual benefit from asparagus, boil its roots in milk and drink it daily, at least twice every day, for it to take effect. The result is it will help you maintain full control over the muscles of your penis.\nFruits are often consumed in their organic form and provide a plethora of health benefits. There are many kinds of fruits which can be eaten for breakfast, and a few of these include:\n- Citrus fruits\nAshwagandha is an herbal plant-bearing edible fruit that can effectively treat sexual problems in men. It potentiates testosterone levels and reproductive health and can increase sperm count and motility. This helps you to have better control over ejaculation and boost your sex life. The best way to take Ashwagandha is to consume it in organic form.\nWatermelon is not just a delicious summer fruit, it offers many health benefits and keeps the body hydrated. It also has antioxidant properties that help fight the free radicals in the body.\nIn terms of providing sexual benefits, watermelon is rich in beta-carotene and lycopene. Both these compounds enhance sexual performance. In addition, watermelon contains citrulline, which is an amino acid that functions efficiently as a vasodilator that enhances penile erection and prevents premature ejaculation. Many may even call watermelon a “natural Viagra”.\nWatermelon is eaten by slicing it into several pieces or making its juice and drinking it.\n4. Dry Fruits\nDry fruits are not only delicious treats, they also offer a whole lot of health-benefiting properties that are vital for the body. A few examples of dry fruits that you can take for breakfast are:\n- Cashew nuts\nWalnuts offer many health benefits to the body and mind. They contain anti-oxidant, anti-inflammatory, and omega-3 properties. Walnuts are also known to be effective at improving erectile dysfunction and premature ejaculation conditions occurring in males. They are also beneficial in increasing sperm motility and morphology.\nWalnuts can be eaten in any form, whether raw, roasted, or as a mixture of snacks before or after meals.\n5. Hot and Cold Beverages\nTaking cold or hot beverages like lemonade, fruit juices, coffee, tea, etc., for breakfast can prove beneficial.\n- Fruit juice\nAvoid grapefruit and grapefruit juice if taking certain medications for ED as this may further worsen the risk of health complications in your body. Take the best juice for erectile dysfunction in your breakfast to improve the sex drive naturally.\nSpices come in different types and contain various properties that are beneficial to health.\n- Turmeric powder (usually mixed with milk)\nGarlic is an essential spice that helps treat premature ejaculation and can aid in prolonging the duration of intercourse. It improves blood circulation in the body. Thus, the increased blood flow stimulated by consuming garlic in foods or beverages is beneficial in treating erectile dysfunction in men.\nGarlic also increases the level of nitric oxide in the blood. Nitric oxide dilates blood vessels and promotes blood flow, and this potentially improves erectile dysfunction and premature ejaculation.\nGinger helps sexually because it has aphrodisiac properties which help improve testosterone production, boost reproductive health, reduce the risk of erectile dysfunction, and improve premature ejaculation. These properties make ginger perfect for men who are suffering from premature ejaculation during intercourse.\n7. Dark Chocolate\nChocolates are another delicious snack that is loved by many – young and old. They contain flavanols that can help increase blood flow and lower blood pressure when eaten. Chocolates are also good for the brain and allow the body to produce more nitric oxide.\nTherefore, eating chocolates or dark chocolates (since they come in different flavors) can help increase sexual desire that will allow men to engage in sexual activity with their partner/spouse.\nED in males can be treated naturally by eating specific foods and drinking beverages that help improve the condition affecting men’s sexual lives.", "label": "Yes"}
{"text": "Super quality Cathayornis yandica fossil bird\nClose up of head preservation\nJust look at the detail of the legs and claws\nView of the body\nWonderful quality fossil bird\nBird Fossil 3\nThis is a wonderful bird fossil, displaying incredible preservation.\nIt is Cathayornis yandica, and was discovered in Liaoning Province, China. It dates from the Early Cretaceous Period, and is 120 million years old.\nThere is a large diversity of bird fossils that have been discovered in the lacustrine deposits of the Western part of Liaoning Province.\nThey are famous for their incredible preservation of these Early Cretaceous bird fossils.\nYou are able to see impressions of plumage on this fossil.\nCathayornis derives its name from the old term \"Cathay\", which was an early name for China.\nIt is forbidden to export these fossils today, so we were very lucky to obtain this as part of an old collection.\nThese seldom come onto the marketplace today.\nAn incredible addition for a collector, and what a talking point it would be.\nMatrix Size: 16cms x 13cms", "label": "Yes"}
{"text": "The same worked for ever smaller and smaller pea plants.\nFred was absolutely joyous when Dean presented him with the unprocessed fingerprint card and promptly tore it into pea-size pieces.\nBianchis Storia della diplomazza euro pea in Italsa (8 vols., Turin, 1865) is an invaluable and thoroughly reliable work.\nFor example, the grub of a pea or bean beetle (Bruchus) is hatched, from the egg laid by its mother on the carpel of a leguminous flower, with three pairs of legs and spiny processes on the prothorax.\nInnumerable clusters of wild cherries (Prunus Chamaecerasus), wild apricots (Amygdalus nana), the Siberian pea-tree (Caragana frutescens), and other deep-rooted shrubs grow at the bottoms of the depressions and on the slopes of the ravines, imparting to the steppe that charm which manifests itself in the popular poetry.\nThe town was burned in August 1863, and shelled on the 3rd of November 1864, after the battle of Pea Ridge, by a detachment of General Price's army.\nFirst came the Imperial Cornet Band of Oz, dressed in emerald velvet uniforms with slashes of pea-green satin and buttons of immense cut emeralds.\nThen he noticed when he bred tall pea plants with another tall plant, he occasionally got a short offspring, but usually tall ones.\nEventually, the pea was as large as its genetic potential allowed it to be.\nThe development of the pea and beanbeetles has been carefully studied by C. V.\nThe sweet potato and pea-nut crops have also become very valuable; on the other hand the Census of 1900 showed a decline in acreage and production of cotton.\nThat range between the smallest pea plant and the largest is the full spectrum of what that plant can be.\n- (Pea Beetle.) Europe.\nIn mineralogical collections rounded nodules of brown glass, varying from the size of a pea to that of an orange, may often be seen labelled marekanite.\nFor a time after entry they multiply, obtaining the nitrogen necessary for their nutrition and growth from the free nitrogen of the air, the carbohydrate required being supplied by the pea or clover plant in whose tissues they make a home.\nIt was the universal custom in medieval England to eat on this Sunday a grey pea steeped and fried in butter, which came from its association \"Carling Nut.\"\nMeanwhile, in the Missouri theatre, the Federal general Curtis, outnumbered and outmanoeuvred by the forces of Price and Van Dorn, fought, and by his magnificent tenacity won, the battle of Pea Ridge (March 7-8), which put an end to the war in this quarter.\nBesides the grasses there are leguminous plants valuable for pasture - Astragalus, Vicia (wild vetch), Lathyrus (wild pea) of which there are many species.\n[According to Zeller, an abstract of the Nicomachean and the Eudemian Ethics, tending to follow the latter, but possibly an early draft of the Nicomachean Ethics.] 3 'H9LKa EbSi) pea or 7rpos Ebbnp.ov: Ethica ad Eudemum: On the same subject.\nGRAM, or Chick-Pea, called also Egyptian pea, or Bengal gram (from Port.\nGRAM, or Chick-Pea, called also Egyptian pea, or Bengal gram (from Port.\nIt was cultivated by the Greeks in Homer's time under the name erebinthos, and is also referred to by Dioscorides as krios from the resemblance of the pea to the head of a ram.\nKulthi), which supplies in Madras the place of the chick-pea, affords seed which, when boiled, is extensively employed as a food for horses and cattle in South India, where also it is eaten in curries.\nMesny, has observed similar evidences of the existence of gold at comparatively shallow depths in Koko Nor region, and records that he has seen nuggets, \" varying from the size of a pea to that of a hazel-nut,\" in eastern Tibet.\nBateson has shown this to be the case for the sweet-pea (Lathyrus odoratus), var.\nLathyrus odoratus (Sweet Pea): hardy; there are two races, dwarf and tall, the latter - far and away the most beautiful - requires support; various colours; numerous immensely popular forms. Lavatera trimestris: hardy, 3 ft., pale-rose, showy malvaceous flowers.\nStoutish erect-growing, 2 to 3 ft., with smooth foliage and spikes of pea-like flowers.\nHigh, with pinnate leaves, and masses of pinkish purple pea-like flowers.\nIn the negotiations of the Treaty of Paris (1783) the Dutch found themselves abandoned by their allies and com elled Pea c e of y, p to accept the disadvantageous but not ungenerous terms accorded to them by Great Britain.\nSuch aggregations of hyphae frequently become knotted up into dense masses of interwoven and closely packed hyphae, varying in size from that of a pin's head or a pea (Peziza, Coprinus) to that of a man's fist or head, and weighing io to 25 lb or more (Polyporus Mylittae, P. tumulosus, Lentinus Woermanni, P. Sapurema, &c.).\nSome petioles are long, slender and sensitive to contact, and function as tendrils by means of which the plant climbs; as in the l,' nasturtiums (Tropaeolum), clematis and c in others; and in compound leaves the midrib and some of the leaflets may similarly be transformed into tendrils, as in the pea and vetch.\nIrritability resides in the pulvinus,in the pea and bean family, in rosaceous plants and the family Rubiaceae.\nIn Leguminous plants (the pea tribe) the pinnae are frequently modified to form tendrils, as in Lathyrus Aphaca, in which the stipules perform the function of true leaves.\nThe natives grow several kinds of bananas, yams and batatas, maize, pea-nuts, sugar-cane, sorghum and pepper.\nThere he accumulated a fortune by control of the garbanzo (chick-pea) crop of the W.\nC. Pyracantha, known in gardens as pyracantha, is evergreen and has white flowers, appearing in May, and fine scarlet fruits of the size of a pea which remain on the tree nearly all the winter.\n- Stamens and Pistil of Sweet Pea (Lathyrus).\nIn 1862 he took a conspicuous part in the desperately fought battle of Pea Ridge, which definitely secured Missouri for the Federals.\nRobinia Pseud-acacia, or false acacia, is cultivated in the milder parts of Britain, and forms a large tree, with beautiful pea-like blossoms. The tree is sometimes called the locust tree.\nThe principal food of the tiger in India is cattle, deer, wild hog and pea-fowl, and occasionally human beings.\nAs it was first observed near the mouth of the river Kur it has been named Cia pea Kurensis.\nCell from the epidermis of root of Pea with \" infection thread \" (zoogloea) pushing its way through the cellwalls.\n(After Prazmowski.) free end of a root-hair of Pea; at the right are particles of earth and on the left a mass of bacteria.\nIn the last forty years of the 18th century pearls were exported from the Scotch fisheries to Paris to the value of £Ioo,000; round pearls, the size of a pea, perfect in every respect, were worth £3 or £4.\nBruchus pisi causes considerable damage to pease; during the spring the beetle lays its eggs in the young pea, which is devoured by the larva which hatches out in it.\nWhile, again, continuous mountain ranges and broad plains and table-lands give the prevailing character to the scenery, there are, on the one hand, lofty isolated peaks, such as Monseny, Montserrat and Mont Sant in Catalonia, the Pea Golosa in Valencia, Moncayo on the borders of Aragon and Old Castile, and, on the other hand, small secluded valleys, such as those of Vich and Olot among the Catalonian Pyrenees.\nThe chick-pea forms part of the daily food of all classes of the inhabitants; and among vegetables.\nFinal d after a vowel has produced u (pea, p e d e in; niu, n i d u m; mou, to o d u m); buf when the d, in consequence of the disappearance of the preceding vowel, rests upon a consonant, it remains and passes into the corresponding surd; f r I g i d u s gives fred (pronounced fret).\nIf pollen is scarce, a substitute in the form of either pea-meal or wheaten flour must be supplied to the bees, as brood-rearing cannot make headway without the nitrogenous element indispensable in the food on which the young are reared.\nThus, in the blossom of the pea (figs.\n- Diagram of flower of Sweet-pea (Lathyrus), showing five sepals (s), two superior, one inferior, and two lateral; five petals (p), one superior, two inferior, and two lateral; ten stamens in two rows (a); and one carpel (c).\n- Flower of Pea (Pisum sativum), showing a papilionaceous corolla, with one petal superior (st) called the standard (vexillum), two inferior (car) called the keel (carina), and two lateral (a) called wings (alae).\nChanges are produced in the whorl of stamens by cohesion of the filaments to a greater or less extent, while the anthers remain free; thus, all the filaments of the androecium may unite, forming a tube round the pistil, or a central bundle when the pistil is abortive, the stamens becoming monadelphous, as occurs in plants of the Mallow tribe; or they may be arranged in two bundles, the stamens being diadelphous, as in Polygala, Fumaria and Pea; in this case the bundles may be equal or unequal.\n- Stamens and pistil of Sweet Pea (Lathyrus).\nPachytheca, a spherical organism, usually about the size of a small pea, found in rocks of Silurian and Devonian age, has been much investigated and discussed, without any decisive light having been thrown on its nature.\nMe ordering a second helping of corn on the cob while dining at the Black Eyed Pea also increases demand for corn, but for doing so, I shouldn't stand trial for murder.\nSoup offerings include split pea, Lentil, and lobster bisque.\nIf you're an adventurous non-vegetarian, try the chef's special Bird's Nest Supreme: sliced white meat chicken, beef and prawns sautéed with pea pods, carrots and baby corn in spicy kung pao sauce, all served in a crunchy noodle bird's nest.\nHealthy brunch menu items include warm organic barley and vanilla bean cereal, veggie burgers with pea shoots and roasted red bell peppers, and buckwheat muesli pancakes.\nLatifolius, the everlasting pea, 6 ft., has bright rosy flowers in the late summer and autumn; the vars.\nThe berries are red or purple in colour, varying in size from that of a pea to a nut.\nThe early history of Navarre has been overlaid with fable, and with pure falsification, largely the work of the Benedictines of San Juan de la Pea near Huesca Their object was to prove the foundation of their house by a.\nBetween 1856 and 1863, he bred 29,000 pea plants.", "label": "Yes"}
{"text": "Endocervical gland structure\nSemantic Scholar uses AI to extract papers important to this topic.\nEzrin, a member of the ezrin/radixin/moesin (ERM) protein family, plays a pivotal role in tumor invasion and metastasis. This… (More)\n- Pathology international\nThe purpose of the present study was to clarify the spreading status of neoplastic cells in the cervical glands and surface… (More)\nUsing the immunohistochemical technique, we investigated the expression of CD10 in normal female genital tissues, chorionic villi… (More)\n- Langenbeck's Archives of Surgery\nAbstract Background. Subtotal parathyroidectomy (SPTX) and total parathyroidectomy with autotransplantation (TPTX and AT) are… (More)\n- The American journal of surgical pathology\nMinimal deviation adenocarcinoma (MDA), or adenoma malignum, of the uterine cervix is a diagnostically problematic disease… (More)\nThe aim of this study was to qualify a staining technique for the diagnosis of adenoma malignum.\nThe gastric… (More)\nThe purpose of this study was to assess the prognostic significance of the expression of estrogen receptor and cell… (More)\nTo provide clues to the histological differentiation between minimal deviation adenocarcinoma (MDA) of the uterine cervix and… (More)\nThe ideal method for preoperative localization of abnormal parathyroid glands has yet to be determined. Technetium-99m… (More)\nVIP-like immunoreactive material is present in the female reproductive tract, with a distinct pattern of distribution. The… (More)", "label": "Yes"}
{"text": "MOSCOW, August 10. /TASS/. A polar whale, which got stranded in a river mouth in Russia’s far eastern Khabarovsk region, has been rescued and is now heading back out to sea, Russian Natural Resources and Environment Minister Sergei Donskoi wrote on Facebook.\n\"A big thank you goes to everyone who participated [in the rescue operation] and expressed concern for the stranded whale,\" he wrote. \"Shantar Islands National Park Director Vladimir Andronov has just called me on the phone saying that the whale has left the river with the tide, the experts have been keeping an eye on him. The whale is now safe,\" the minister added.\nAccording to previous reports, during high tide, a 13-meter-long great polar whale got into the river flowing out of Lake Bolshoye on the Bolshoy Shantar Island located in the Sea of Okhotsk, in Russia’s Khabarovsk region. The mammal had been apparently chased into the river by a school of killer whales. It had been wounded and was very much frightened.\nScientists and experts from Russia’s Emergencies Ministry waited for the night high tide to herd the whale away from the shore. During low tide, inspectors from the Shatnar Islands National Park had been keeping the whale wet using water pumps.\nThe Shantar Islands is an archipelago with an area of 2,500 square kilometers, located off the northwestern shore of the Sea of Okhotsk. As many as 240 bird species inhabit the islands, 30 of which are listed in the Red Book of Russia. There are also rookeries of the Steller sea lions and spotted seals, included in the Red Book. Besides, polar whales often hang out in the area. The archipelago is a special protected area included in the Shantar Islands National Park.", "label": "Yes"}
{"text": "Jodi A. Hilty\nLandscape and Seascape Science, Planning, and Action\nClimate and Conservation offers readers tangible, place-based examples of projects designed to protect large landscapes as a means of conserving biodiversity in the face of the looming threat of global climate change.\n- Copyright year: 2012\nLinking Landscapes for Biodiversity Conservation and Climate Adaptation\nThis second edition of Corridor Ecology: Linking Landscapes for Biodiversity Conservation and Climate Adaptation captures advances in the field over the past ten years. It features a new chapter on marine corridors and the effects of climate change on habitat, as well as a discussion of corridors in the air for migrating flying species. Practitioners, land managers, and scholars of ecology will find it an indispensable resource.\n- Copyright year: 2019\nReceive the latest UBC Press news, including events, catalogues, and announcements.", "label": "Yes"}
{"text": "Uremic toxins are associated with persistent kidney disease (CKD)-related systemic diseases. advanced CKD sufferers for the preservation of kidney function although some huge interventional clinical research did not present clear influence on it [42C46]. Reduced amount of uremic poisons with AST-120 may be connected with better final results in CKD-related systemic disease. Actually, kidney damage-induced acceleration of atherosclerosis was modulated with administration of AST-120, with much less aortic deposition of Is normally and aortic appearance of inflammatory cytokines . Another scholarly research demonstrated that AST-120 modulated CKD-induced cardiac harm, with reduced serum/urine levels of Moxifloxacin HCl irreversible inhibition Is definitely and oxidative stress markers, such as 8-hydroxy-2-deoxyguanosine and acrolein, inside a rat model . Is definitely strongly bound to high molecular excess weight protein and is difficult to remove with standard dialysis treatment. A medical study showed that IS in serum is definitely 97.7% protein-bound and is only reduced by 31.8% with standard hemodialysis . Recent findings showed that a longer hemodialysis treatment session , use of large-pore, super-flux cellulose triacetate membranes , and hemodiafiltration  improved the removal of protein-bound uremic toxins; however, these changes are thought to be insufficient to prevent CKD-related complications. Additional therapy with standard dialysis is needed to properly remove protein-bound uremic toxins. For example, when anuric individuals undergoing maintenance hemodialysis used AST-120 6?g/day time for 2?weeks, serum IS, em p /em -cresyl sulfate, and phenyl sulfate levels in the predialysis RUNX2 session decreased significantly , while did oxidative stress markers including oxidized albumin and 8-isoprostane . The Lixelle? column contains porous hexadecyl-immobilized cellulose beads and was developed for direct hemoperfusion of blood 2-m with hydrophobic relationships [52, 53]. Recent research found that hexadecyl-immobilized cellulose beads adsorbed protein-unbound free Is definitely, em p /em -cresyl sulfate, phenyl sulfate, and IAA to some degree . These interventions are problematic in clinical use, and further Moxifloxacin HCl irreversible inhibition medical investigation will become necessary to properly reduce uremic toxins. Methods for decrease include concentrating on of intestinal flora that generate uremic poisons, removal of circulating uremic poisons, among others (Fig.?3). Remedies in each stage shall lower uremic poisons and stop CKD-related systemic disorders. In addition, sufficient removal of protein-bound uremic poisons should be suggested when the interventions can improve success and ADL/QOL in CKD sufferers. Open in another screen Fig. 3 Healing approaches for uremic toxin-related systemic disorders. Healing Moxifloxacin HCl irreversible inhibition approaches for the reduced amount of uremic poisons will include (A) preservation of kidney function, (B) inhibition of uremic toxin creation, (C) prevention from the connections between uremic poisons and tissue/cells, and (D) removal of uremic poisons with medicine or bloodstream purification therapy Bottom line Uremic poisons and CKD-related illnesses, centered on 2-m-related amyloidosis and IS-induced acceleration of atherosclerosis, had been reviewed, predicated on current understanding and upcoming perspectives. Deposition of uremic poisons can induce several systemic disorders, and each uremic toxin provides unique characteristics, such as for example conformational transformation and protein-binding properties in the condition establishing. Further studies will be needed to determine the characteristics of each Moxifloxacin HCl irreversible inhibition uremic toxin in greater detail and to develop restorative strategies for improved survival and ADL/QOL in CKD individuals. Acknowledgements I say thanks to the Japanese Society of Nephrology for the 2016 Oshima Award. I am thankful to the many investigators and colleagues in the area of uremic toxin study with whom I have had the enjoyment to work during this and additional related projects. I am especially thankful for Moxifloxacin HCl irreversible inhibition the mentorship of Drs. Fumitake Gejyo and Ichiei Narita in Niigata University or college Graduate School of Medical and Dental care Sciences. Notes Discord of interest All authors declared that they have no discord of interest. Ethical approval This short article does not consist of any original studies with human participants or animals performed by any of the authors. Footnotes This short article was offered as the Oshima Honor memorial lecture in the 59th annual achieving of the Japanese Society of Nephrology, held at Yokohama, Japan in 2016..", "label": "Yes"}
{"text": "My current research is on\ntherapeutic strategy and clinical assay development for multiple myeloma. My\nprojects are to find cancer stem cell-targeted therapies and second, to develop\nan assay to help guide treatment decision making. My technical expertise is in\nflow cytometry and the dissection of myeloma cell populations in patient\nsamples and determining their drug sensitivities.\nPrior to coming to the University of Colorado, I was at Northwestern University’s Center for Innovation in Global Health Technologies in Chicago. There I worked on the development of molecular point-of-care diagnostics for HIV and Tuberculosis for use in sub-Saharan Africa.\nI received my master’s degree in biology from Northern Arizona University in Flagstaff. My research focused on the characterization of bacterial and fungal communities in soils using stable isotope probing, next gen sequencing and real-time PCR.\nIn my free time I love to explore Colorado’s numerous outdoor activities including cycling and mountain biking as well as spending time with my family.", "label": "Yes"}
{"text": "Early Steps in the Processing of Amyloid Precursor Protein\nAPP is synthesized in a part of the cell called the endoplasmic reticulum (ER), where it undergoes a number of changes. In AD, the processing of APP is altered, leading to overproduction of the amyloid protein Ab42. However, it is not yet clear what causes the production of Ab42 in the ER. Dr. Goldgaber has hypothesized that as APP is synthesized and inserted into the ER, it interacts with specialized proteins called chaperones. Chaperones are known to be important in helping newly synthesized proteins fold into their proper three-dimensional shape. In Dr. Goldgaber's hypothesis, the interaction between APP and chaperones is required to ensure that the APP is properly modified and processed. He believes that misfolded or mutant APP may be targeted for some type of protein degradation, which could lead to the production of Ab42. He is exploring a number of approaches for studying the role of chaperones in the processing of normal and mutant APP.", "label": "Yes"}
{"text": "There was blueberries for everyone.\n-pg. 318, Wagon Trails to Hardtop\nThe historical perspectives offered in this exhibit have been gleaned from the history books compiled in the past by our local historical societies, namely Wagon Trails to Hardtop, Land of the Lakes, and From Pioneers to Progress. Therefore, these perspectives have been provided by the early European settlers of this region, often by the mothers, daughters, and granddaughters that came before us. Sometimes by the first person in a family to settle, sometimes by someone in the next generation. So, it is necessary to consider some of the information presented through that lens. In this exhibit, we invite you to consider the land we live on, the plants that grow on it, and how this has changed over time.\nThis land that is being covered, Lacombe County, exists in Treaty 6 territory. We invite all guests to read Treaty 6 and learn more about what it means to be treaty people. This land also resides in Métis Nation Region 3. This land is the traditional territory of plains peoples. Of the Nêhiyaw, Métis, Niitsítpiis-stahkoii, Očhéthi Šakówiŋ, and Tsuu T’ina peoples. The county contains sites of great significance to First Nations and Métis peoples as well as important historical travel and trade routes. First Nations, Métis, and Inuit peoples have traveled, traded, told stories, and had relations on this land for millennia. A connection to the land is also a connection to the plants, and animals, that live here.\nNative-lands.ca Interactive Map\nWith the interactive map from Native-Lands, you can explore in more detail the traditional territories that you reside on. The map can be filtered by: territories, languages, and treaties. To add modern-day political boundaries and settlements to the map click “Settler Labels” at the bottom right.\nThe land that is talked about throughout this exhibit is Lacombe County. This is a large, and diverse area. To the east this land touches the shores of Buffalo Lake, to the south the border touches the north shores of the Red Deer and Blindman Rivers, as well as Sylvan Lake. Westward the county stretches just past the Medicine Lodge Hills. And to the north the county generally lies south of township 42 while also hugging the shores of Gull Lake.\nIf you were to drive across the county much of the land would be similar in appearance as the entire county lies within the Central Parkland Region, but such a large area is definitely not uniform. If you began in the west, you would see large stretches of farm land that will become extremely familiar throughout your drive.\nOpen fields would stretch out in all directions, but as you drive east the land would make a dramatic change as you approach the Medicine Lodge Hills which reach elevations of just over 1000 meters. The peaks of these hills can be seen from great distances in all directions. The land around the hills gives a brief break from vast sections of farmlands and reminds of the wilderness that once covered this particular area. To the south you might see the shimmer of the shores of Sylvan Lake. You will cross the Blindman River, and pass Bentley, before you need to peek through the trees lining its shores to get a glimpse of Gull Lake. The straight stretch of Highway Twelve will let you see Lacombe for some time before you drive through. Taking this relatively straight route on Highway Twelve will mean you miss the well treed shores of Lacombe Lake, the long, narrow length of Blackfalds Lake cut into sandy shores, the high banks of the Red Deer River, but also the low banks of sections of the Red Deer, and Blindman, Rivers that allowed for river crossings in the past. You might get the sense as you go eastward that the land is holding more water. This end of the county is full of sloughs, ponds, and lakes.\nSome of these bodies of water are named: Chain Lakes, Alix Lake, Gadsby Lake, Haunted Lakes, Parlby Lake, but many are not. Buffalo Lake is impressive in both size, and shape. Its many coves, bays, islands, and surrounding wetlands have attracted people long before European settlers ever arrived in this area.\nThe landscape has been shaped by human hands for as long as humans have lived on the land. Before European settlers arrived to this area the land was already marked and named by the people that were living here. The landscape in the Eastern part of the county at Buffalo Lake and Tail Creek had been home to Metis people that came to hunt bison in the winter months. They would have had names for the places where they lived and hunted. They left behind cabins that are now indentations upon the landscape. Settlers reported finding large numbers of bison bones in many areas of the county, left behind from numerous hunts over the years. Around the province the shapes of cliffs and hillsides have been altered due to bison hunting. Trails criss-crossed the region long before roads, railways, or permanent European settlement. The well-worn routes carved paths of least resistance into the landscape to aid travel and trade.\nBefore the arrival of Europeans Indigenous peoples used traditional methods to tend to the lands in North America. In many areas fire was used. There are many different benefits to controlled fires. Fire can rid areas of disease, prune dead branches, and encourage regrowth of certain plants. The landscape was influenced by these practices that often were used to ensure adequate amounts of food could be harvested. Controlled fires can prevent larger, destructive wildfires as they use the plant debris that would be fuel for such a fire. They can also be used to manage the grazing of bison. A fire would result in new grass growth that could attract bison in the following growing season.\nSettlers arrived to, and in many instances subsequently abandoned, homesteads and other endeavors. The landscape tells their stories through the things they left behind: the foundations of houses, stoves that were too heavy to move, rubbish piles full of jars that will never break down, remnants of saw-mills left in the woods, and plants that they introduced to the landscape when they arrived and filled their yards with gardens of familiar flora. Once people permanently settled, larger and more permanent changes were enacted upon the landscape. Agriculture began, roads were built, water drained and rerouted, trees cut down.\nPeople name the landscape. To make it easier to find our way through it, to make it easier to tell our stories, and to describe the relationship that we have with it. Lacombe has not always been called Lacombe. Each name it has had describes a different relationship that the people living here have had with it. Lacombe of course evokes Father Lacombe. But before it had been referred to as Strawberry Plain, Siding 12, and Barnett’s Landing. Strawberry Plain could refer to an abundance of the aforementioned fruit, but the source that uses this name does not provide further explanation. Siding 12 was a utilitarian name provided by the rail company. Barnett’s Landing refers to the first European settler in Lacombe and the stopping house he operated.\nDid You Know\nThe bison that once roamed the North American prairies in great numbers also greatly impacted the landscape. Bison of course would fertilize the grasslands with their manure, and with their remains when they passed away. They would also create wallows, or little indentations when they had dust baths. These wallows are important parts of a prairie ecosystem. They can attract pioneer plant species that like to take advantage of freshly disturbed soil, and can eventually hold water. This creates small ponds that serve as homes for both flora and fauna that require moisture to thrive. Their coats, which are much denser than that of cattle, can collect seeds, which are redistributed as they travel. The seeds in their coats can end up far from their original source when the bison sheds its coat helping to increase the density and diversity of some plant species.\nThe natural environment that we live in on the prairies and in the parkland region developed alongside the bison, with each needing the other to thrive.\nCentral Parkland Region\n“In its native state, the ground was covered by poplar and willow trees.”\n-pg. 254, Wagon Trails to Hardtop\nAll of the land that was passed over in the imaginary drive of The Land section, and a majority of the areas of Alberta with the densest population, lie within the Parkland Region. This region is the very northern tip of what is referred to as the Great Plains and was once home to bison herds. This means that the Central Parkland rests against the grasslands that are characteristic of the Great Plains, but also contains patches of willow and aspen that have earned this region the nickname “Aspenland”. The glaciers that once covered most of North America left this region with its characteristic low, gently rolling hills. The wetlands that make 5-10% of this region are sometimes referred to as the “duck factory” of North America.\nThe Parkland Region is unique to North America. It is estimated that today only 5% of the Central Parkland remains as native vegetation, yet 20% of Alberta’s rare, vascular plants can be found in this region. The areas that remain homes to native vegetation are unsuitable for agriculture so have managed to be uncultivated.\nThe area Lacombe County lies in is specifically a part of Central Parkland. The southeast of this region is the driest, so is where the most grassland-type characteristics can be found. This would make a mixture of grasses and plants like pasturewort dominant. Moving toward the northwest means moister conditions and more and more aspens. Plant species like beaked hazelnut, bunchberry, wild lily of the valley, and wild sarsaparilla occur in central parkland but not in its neighbour directly west, the foothills.\nOn light to moderately grazed sites plains rough fescue shares dominance with perennial herbs like prairie crocus, prairie sagewort, wild blue flax, northern bedstraw, three flowered avens, buckbrush, silverberry, prickly rose, chokecherry, and saskatoon are found throughout the region.\nThe following photos from our collection are all from the early 20th century and were taken in different places around the county. Each was chosen as we can easily see the diversity in the plant life in the photos even if it is difficult to identify the plants themselves. In the photo taken in Lacombe we can see an abundance of flowers and grasses growing before major building developments disturbed their habitat. The picture at Gull Lake shows an amazing diversity of typical Central Parkland plants including what appears to be yarrow and an artemisia variety (prairie sagewort) among the grasses.\nFauna Past and Present\n“There must have been many such plants across the prairie that might have produced excellent strains of their kind, well suited to this climate, but lost because the plow preceded the botanist.”\n-pg. 38, Land of the Lakes\nWhen looking at how the land and the landscape has changed over time it is very easy to come across references to plants that we are no longer familiar with in this area. As stated at the beginning of the page the historical perspectives used in this exhibit are from local history books. The books often allowed local families to submit their own account of their family’s settlement in the area, either through first hand experience or via recollections of stories that the person submitting the story heard from older family members. The accounts can span from the first settlement in the late 19th century, usually to the 1930s if covering the “first” settlers. This is both a large range in time, and small, when we consider that in just a few decades the way the land was used had completely changed. These accounts tell us about a land that is alien to its modern residents.\nAgriculture, though an important part of prairie life and our modern-day economy, has decimated native plants in our Parkland home. As the quotation that is used for the subheading implies, we unfortunately lost the biological diversity of this reason due to the plough. We now know that the native plants of the prairies had incredibly important roles in their ecosystems that settlement and agriculture disrupted. Native animals and insects, like bees and butterflies, adapted to the native plants that they live side-by-side and rely on them for food. The native plants of this region, especially the grasses, have incredibly large root systems which ecologists are still trying to understand but may guard the land from erosion, could help hold moisture in the ground, and can help plant life be return after a fire.\nOne such change, and one such disappeared plant, is blueberries, the plant that gave this exhibit its name. Perhaps some people in the county have treasured secret blueberry patches on their land but they are no longer found in the numbers those early settlers knew. The multiple accounts about this plant in local history books would lead a reader to believe that just a few decades ago the landscape was a blanket of the humble, low growing blueberry bush. Every corner of the county seems to have an account of settlers picking blueberries by the bucket full. The museum collection contains more than one example of blueberry pickers due to the prevalence of this plant just a few decades ago. The low-lying fruit would be combed off the plant into a scoop, making their harvest with a picker more efficient than plucking the fruits by hand.\nMany other flowers and plants referenced in local history books have declined greatly in numbers, some now only extremely rarely spotted by humans.\nOne day while out breaking the land they saw in the distance the ground blue with blueberries. They stopped breaking the land and picked tubs full of berries which they ran through the fanning mill to blow out the leaves.\n-pg. 392, Wagon Trails to Hardtop\n“It was said that blueberries were so plentiful near the river as to have the juice drip off the wagon wheels.”\n-pg. 2, Wagon Trails to Hardtop\nThe accounts of wild fruits in this area, just as with wildflowers, speak of abundance. While blueberries may be relatively unfamiliar as the land is no longer blanketed in these plants, the rest of the fruits may be familiar to those that spend time in the wild corners of the county. Many of the fruits may not exist in the numbers that the early settlers would have seen, but they have not been pushed out of their former habitat yet, just to the edges that are unsuitable for agriculture. The land is home to many fruits: saskatoons, strawberries, cranberries, pincherries, chokecherries, dewberries, currants, gooseberries, and hazelnuts.\nIt has been many years since wild fruits could be found in any quantity.\npg. 39, Land of the Lakes\n“The hills and meadows were a blaze of colour from wildflowers.”\n-pg. 37, Kid Ray, Land of the Lakes\nThe colourful, wildflower filled landscape may be a thing of the past, but maybe this only adds to the excitement lovers of the wild experience when they catch a glimpse of many of the flowers mentioned here in their natural habitat. Though not in their natural habitat the museum experienced just such excitement not long ago. The museum collection had been holding a secret until recently. Between the pages of books were hiding pressed flowers from the Gull Lake area. The donor had unknowingly gifted dried flowers, both wild and garden varieties. Pictured here are the flowers as found between the pages, seemingly placed there many years ago by a nature lover. The identifications have not been provided by a professional, but some plants should have a familiarity for gardeners or modern nature lovers. Many of the plants appear to be common, but if the lily specimens are from the native, Western Red Lily, then this exciting find contains an example of a flower that is almost just a memory in our area. Reported to have grown in large numbers in the past, these flowers have been heavily disturbed, and exist in much smaller numbers today, hidden from cultivation and grazing. To learn more about this amazing find read our Field Note about the Herbarium Collection.\nMary Vaux Walcott\nThe botanical drawings featured here are all by Mary Vaux Walcott. Today her art is in the care of the Smithsonian American Art Museum. Mary was an American artist, botanist, and geologist that spent much of her time in the Canadian West. Mary is perhaps best known for her botanical illustrations and has been called the “Audobon of Botony”, but she was also an accomplished mountaineer with a peak near Jasper named after her, and provided important data on receding glaciers in the Canadian Rockies. The illustrations here demonstrate the beauty and diversity of botanical specimens in Alberta. If you look carefully in the bottom left corners of the illustrations you may see the names of many familiar locations in the province.", "label": "Yes"}
{"text": "The Nose-Horned Viper (Vipera ammodytes ammodytes) is a highly venomous reptile in the Viperidae family of viper snakes. It is a viperid. It is also known as the Horned Viper and Western Sand Viper. Scientists think it might be the most dangerous snake in Europe.\nThe Nose-Horned Viper has a head covered with small, irregular scales that can be smooth or slightly keeled (ridged). It has 10-13 small scales around its eyes. The nasal (nose) scale is large that looks like a horn with 9-17 smaller scales along it, but it is soft and flexible.\nThe male has irregular dark-brown, dark-grey, or black markings and a thick black stripe from its eye to its jaw. The male has V-shaped markings on its back like a zig-zag pattern. The female lacks the dark V-shaped markings on its body, and is browner and more bronze-coloured than the male. Its underbelly can be grey, yellowish-brown, or pinkish. Both have a black tongue and golden or copper-coloured eyes.\nIt grows to 50-70 centimetres (20-28 inches) long. The female is usually larger than the male. Its fangs are 1.3 centimetres (half an inch) long.\nIt is found in southern Europe, the Balkans and parts of the Middle East. It is a burrowing snake and often hides in the sand. It also likes rocky habitats.\nThe Nose-Horned Viper is usually diurnal, more active during the day. It hibernates in winter for 2-6 months, depending on its location.\nIt feeds on small mammas and birds. Younger Vipers eat lizards. It kills its larger prey with its sharp fangs, but smaller prey is often swallowed without using its venomous fangs to kill it first.\nThe female is ovoviviparous. She has 1-20 live young, called snakelets, which are 14-24 centimetres (5-9 inches) long when they are born.\nLocation of photographs: Parc Zoologique de Paris in Bois de Vincennes, France\nPhotographer: Martina Nicolls\nMartina Nicolls: SIMILAR BUT DIFFERENT IN THE ANIMAL KINGDOM", "label": "Yes"}
{"text": "There is one place in Zambia to see outstanding sightings of leopards and that’s South Luangwa.\nA pride of lions take down the first elephant of the season in Savuti.\nA lone lioness is attacked by a pride’s dominant male.\nA spotted hyena fishes out the rotting meat of a carcass in one of Etosha’s dams.\nA python proves that its bark-like camouflage scales are just as bad as its bite when it kills a turtle dove.\nThe leopard: nature’s most enigmatic predator, a true work of art.\nA look at cheetah and hyena cubs – we can’t decide which is cuter!\nScott soaks up the natural wonders of Kruger: lions, bull elephants, happy hippo herds and hidden leopards.\nAn important cheetah lesson as a mother cheetah teaches her cubs how to stalk their prey.\nWill Burrard-Lucas’ wildebeest time-lapse video has been commended in the new time-lapse category of the prestigious Wildlife Photographer of the Year competition.\nScott Ramsay is lucky enough to see all five of the Timbavati white lions: two adult lionesses and three white lion cubs.\nTwo lionesses with 6 cubs face a daunting deep river crossing. Two of the cubs refuse the swim and get separated with potentially devastating consequences. You won’t believe the dedication of the mothers.\nDiscover South Luangwa by way of a river journey in Emerald Season discover a landscape that is alive with greenery and wildlife.\nAn orphaned elephant is rescued from Milgis Lugga, Kenya along with two tiny ostrich chicks.\nThe elusive black cat is back!\nAction between zebras and lions at Salvadora waterhole in Etosha.\nThe return of the buffalo to Liuwa Plain National Park, Zambia\nAn adorable photo selection of a playful group of wild dogs with their pups.\n10 reasons why safari hides are not just for bird watchers and wildlife documentary photographers.\nBrandy, has successfully recovered from her snare injuries. Whether the incident had terminated her pregnancy remains to be seen but experts are hopeful.\nPhotos of an African rock python taking down a vervet monkey in Tanzania’s Katavi National Park.\nWe join Ivanhoe Sea Safaris a whale watching experience in Gansbaai.\nCarnivore Conservation Research Project collaborating with Namibian farmers to help resolve the human/predators conflict.\nWill Kent talks about some of the experiences he had in South Africa as a volunteer.\nWhat does one do when a lion charges you on foot? Bushwise has the answer!\nDuring our recent Africa Geographic visit to Namibia, we shared a rather special moment with a family of desert elephants, as they settled down for a mid-morning siesta.\nGuests were treated to a tender moment between elephants in Lewa Wildlife Conservancy.\nTuli Safari Lodge in the Northern Tuli Game Reserve, Botswana, must be one of the only places in Africa that can guarantee excellent sightings of elephant shrews.\nPhotos of a dramatic moment involving a pack of wild dogs and a huge crocodile in Kruger National Park.\nAfrica Geographic Travel recently ran its first photographic workshop at Samara Private Game Reserve with Mark Drysdale and what a success it was!\nStudying spotted hyenas via radio collars to find out how their societal structure bucks the trends researchers see in other mammals.\nThere has been a ground-breaking discovery and naming of two new species of monkey moths in the iSimangaliso Wetland Park in South Africa.\nBen Coley talks about the magic that is the African bushveld.\nWonderful photographs of golden backlit lions playing in the dust.\nAn amazing moment with two crocodiles engaged in what appears to be a mating ritual.\nDavid Sheldrick Wildlife Trust rescues one of Tsavo’s bull elephants that was injured by a poacher.\nA leopard leaps from a tree in Moremi Game Reserve onto an impala grazing below.\nGrahamstown researchers discover a new species of redfin minnow\nPhotographs that celebrate the lovely leopards of the Timbavati.\nThe Bangweulu Wetlands Project’s latest member, Seymour, the little chick who survived.\nDr. Simon Morgan, from Wildlife ACT, answers some questions asked about the strange behaviour of the genet who was caught hitchhiking.\nA grey heron uses a local waterhole as his fishing ground for finch food.\nAn amazing sighting of a baby honey badger in Botswana’s Linyanti concession.\nAll about African wild dogs…\nThe spectacle that is the Mara River crossing during the great migration.\nFor those of you who were surprised to see a large spotted genet riding a buffalo, he is back – this time for some rhino riding!!", "label": "Yes"}
{"text": "Goat anti calreticulin antibodyrecognises calreticulin, a 418 aminoacid ~60 kDa Ca2+ binding chaperone involved in protein modification and folding within the endoplasmic reticulum (UniProt: P15253).\n- Species Cross-Reactivity\nTarget Species Cross Reactivity Mouse Rabbit Human Rat\n- N.B. Antibody reactivity and working conditions may vary between species.\n- Product Form\n- Serum - liquid\n- Antiserum Preparation\n- Antisera to calreticulin were raised by repeated immunisation of goats with highly purified antigen.\n- Buffer Solution\n- Glycine buffered saline\n- Preservative Stabilisers\n0.09% Sodium Azide\n- Purified rabbit skeletal muscle calreticulin.\n- Store at +4oC or at -20oC if preferred.\nThis product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.\n- Shelf Life\n- 18 months from date of despatch.\n- P15253 Related reagents\n- Entrez Gene\n- CALR Related reagents\n- GO Terms\n- GO:0051082 unfolded protein binding\n- GO:0005509 calcium ion binding\n- GO:0006457 protein folding\n- GO:0005529 sugar binding\n- GO:0005788 endoplasmic reticulum lumen\n- For research purposes only\nApplications of Calreticulin antibody\n|Application Name||Verified||Min Dilution||Max Dilution|\n|Immunohistology - Frozen||1/50||1/70|\nWhere this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.\nCopyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)\nSecondary Antibodies Available\n|Description||Product Code||Pack Size||Applications||List Price||Quantity|\n|Rabbit anti Goat IgG (Fc):FITC||STAR122F||1 mg||F|\n|Rabbit anti Goat IgG (Fc):HRP||STAR122P||1 mg||C E WB|\nProduct Specific References\nReferences for Calreticulin antibody\nMilner, R.E. et al. (1991) Calreticulin, and not calsequestrin, is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum.\nJ Biol Chem. 266 (11): 7155-65.\nMichalak, M. et al. (1991) Identification and immunolocalization of calreticulin in pancreatic cells: no evidence for \"calciosomes\".\nExp Cell Res. 197 (1): 91-9.\nSanter, D.M. et al. (2010) C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes.\nJ Immunol. 185 (8): 4738-49.", "label": "Yes"}
{"text": "A tradition at the International Crane Foundation is to follow our “Egg Scorecard,” which tracks the Whooping Crane eggs from our captive flock and wild nests in Wisconsin.\nWe’ll be posting updates to our scorecard on our website, Facebook, Twitter and Instagram, so check back often in the coming weeks to view our progress. Click here to learn more about Whooping Cranes.\nWhooping Crane eggs laid/chicks hatched at the International Crane Foundation – 5/22/19\nOur naming theme this year is Game of Thrones. Stay tuned for some creative names!\nEggs laid: 9\nFertile: 3 – 1 transferred to Milwaukee County Zoo and has hatched! We also have 2 fertile Hooded Crane eggs.\nChicks! – 6 The chick’s names this year are Nymeria, Wilding, Viserion, Bravos, Sir Davos and Kit\nEastern Migratory Population eggs: 17 fertile eggs were transported to our headquarters from nests at Necedah National Wildlife Refuge during black fly emergence on April 21. Five eggs have been transferred to our partners at the Freeport-McMoran Audubon Species Survival Center in Louisiana.\nWild Whooping Crane nests and chicks in Wisconsin – 5/23/19\nNote: Each crane is identified by a two-part number (e.g. 12-11), with the second number identifying the hatch year. A “W” indicates that the crane hatched in the wild.\nNew in 2019! View the Where are the Whoopers interactive map to view the last known location of cranes in the Eastern Migratory Population.\nChicks! – 4\n12/5-11 – 1 chick – W1-19\n42/24-09 – 1 chick – W2-19\n27-14/10-11 – 2 chicks – 1 remaining – W3-19\nW3-10/8-04 – 1 chick – W5-19\n15-1129-08 – 2 chicks\nCurrent active nests: 10\n28-05/2-15 – 2 females", "label": "Yes"}
{"text": "The healing power of LSD\nHallucinogen may help alcoholics give up the drink\nNew research analyzing data from studies conducted between 1966 and 1970 suggests LSD may help alcoholics quit and remain sober.\nIn a study that appeared in the Journal of Psychopharmacology, researchers from the Norwegian University of Science and Technology took a fresh look at data from six different studies conducted in the United States and Canada, according to Health.com. The researchers concluded a single dose of the hallucinogen helped heavy alcoholics quit and reduced their risk of relapse. In addition, 59 percent of patients showed a clear improvement after receiving a full dose of LSD, compared to 38 percent of patients who did not take the drug. Study authors Teri Krebs and Pal-Orjan Johansen speculated the results were linked to LSD’s effect on serotonin receptors in the brain.\n“LSD may stimulate the formation of new connections and patterns, and generally seems to open an individual to an awareness of new perspectives and opportunities for action,” wrote Krebs and Johansen.", "label": "Yes"}
{"text": "Second-Hand Smoke Just as Harmful to Fetuses as First-Hand Smoke\nResearchers at the University of Pittsburgh Graduate School of Public Health found that abnormalities in these newborns were identical to those found in newborns of mothers who actively smoked during pregnancy. These genetic mutations may affect survival, birth weight, and susceptibility rto diseases such as cancer. The study was published online in the Open Pediatric Medicine Journal.\nStudy author Stephen G. Grant, Ph.D., associate professor of environmental and occupational health at the University of Pittsburgh Graduate School of Public Health, led a previous study in which abnormalities were discovered in the HPRT gene located on the X chromosome in cord blood from newborns who were prenatally exposed to second-hand smoke.\nIn the new study, Dr. Grant found the same mutation in another gene called glycophorin A (GPA), which represents oncogenes, or genes that transform normal cells into cancer cells, causing tumors. He found that this mutation was the same as that found in newborns of mothers who actively smoked during pregnancy and non-smokers who were exposed to cigarette smoke. The mutations were also the same in newborns of mothers who stopped smoking during pregnancy but were still exposed to second-hand smoke.\nDr. Grant said these new findings underscore their previous discovery that second-hand smoke can cause permanent damage in newborns. They were able to find a distinct yet equally important type of genetic mutation that is likely to remain throughout the individual’s lifetime.\nDr. Grant stressed that pregnant women should not only stop smoking, but also reduce their exposure to second-hand smoke.\nSource: University of Pittsburgh Graduate School of Public Health, Exposure to Secondhand Smoke in the Womb Has Lifelong Impact, July 1, 2010", "label": "Yes"}
{"text": "Viramune: An Essential Medication for HIV Treatment and AIDS Prevention\nViramune, also known by its generic name nevirapine, is a prescription medication that plays a crucial role in the treatment of HIV infection and lowering the risk of developing AIDS. This article explores the various aspects of Viramune, including its importance in a comprehensive HIV treatment plan, different forms available, and the affordability of generic options for those with limited resources or no insurance coverage.\n1. Overview of Viramune\nViramune is a prescription medication specifically designed to combat HIV infection and reduce the chances of progressing to AIDS. As part of a comprehensive HIV treatment plan, it works in conjunction with other medications and lifestyle changes to effectively manage the disease.\n2. Understanding the Generic Name\nThe generic name of Viramune is nevirapine. Understanding this term is essential as it not only helps in identifying the medication but also assists individuals in locating generic versions that may be more affordable or readily available.\n3. Incorporating Viramune in HIV Treatment\nViramune should be used alongside other prescribed medications and lifestyle modifications as part of a comprehensive HIV treatment plan. This multi-faceted approach ensures the best possible outcomes in managing the infection and preventing the advancement to AIDS. It is crucial to follow healthcare provider’s instructions and adopt a holistic approach to HIV treatment.\n4. Varieties of Viramune\nViramune is available in different forms, such as tablets and suspension, to cater to individual patient needs. These variations provide flexibility in administration and accommodate preferences or specific requirements of each patient.\n5. Generic Options for Affordable Treatment\nIt is important to note that generic versions of Viramune are available. These options are often more affordable and accessible for individuals with low wages or without insurance coverage. The use of generic Viramune plays a significant role in ensuring access to essential HIV medication for all individuals.\nIn conclusion, Viramune is a vital medication in the treatment of HIV infection and the prevention of AIDS. Understanding its role in a comprehensive HIV treatment plan, the availability of generic options, and the different forms it comes in helps individuals make informed decisions about their healthcare. By highlighting the affordability and accessibility of generic Viramune, we aim to improve access to this essential medication for all individuals.\nInsight into the Most Significant General Health Medicines Developed\nGeneral health medicines play a crucial role in improving overall well-being and addressing common health concerns. These medications have been developed to effectively manage conditions such as high blood pressure, diabetes, and cholesterol. With limited resources or access to healthcare services, these medicines offer great benefits. Let’s take a closer look at some of the most significant general health medicines available on the market:\n1. Medication for High Blood Pressure\nHigh blood pressure, also known as hypertension, is a prevalent health concern affecting millions worldwide. Medications such as lisinopril and amlodipine have proven to be highly effective in reducing blood pressure levels. These drugs work by relaxing blood vessels, thereby lowering the risk of heart disease, stroke, and kidney problems.\n2. Medication for Diabetes\nDiabetes, a chronic condition characterized by high blood sugar levels, requires careful management. Metformin and glipizide are commonly used medications for type 2 diabetes. They help control blood sugar levels and improve insulin sensitivity, reducing the risk of complications associated with diabetes.\n3. Medication for Cholesterol Management\nElevated cholesterol levels can contribute to heart disease and other cardiovascular problems. Atorvastatin and rosuvastatin are widely prescribed medications that effectively lower cholesterol levels. By inhibiting cholesterol production in the liver, these drugs help reduce the risk of heart attacks and strokes.\nThese general health medicines have transformed the lives of many individuals by effectively managing their respective conditions. Success stories abound, showcasing the positive impact these medications can have on overall well-being.\nIt’s important to note that while general health medicines can be highly beneficial, it is crucial to consult with healthcare providers or pharmacists before starting any new medication. They can provide personalized guidance based on your individual health circumstances and potential interactions with other drugs.\nFor more information about these medications, their uses, and potential side effects, you can visit trusted sources such as the Mayo Clinic and the National Institutes of Health.\nViramune’s Influence on the Effectiveness of Hormonal Contraceptives or Hormone Replacement Therapies\nWhen considering the use of Viramune as part of your HIV treatment plan, it is crucial to understand its potential interaction with hormonal contraceptives or hormone replacement therapies.\nInteraction with Hormonal Contraceptives:\nStudies and research have suggested that Viramune may decrease the effectiveness of hormonal contraceptives, such as birth control pills, implants, or patches. This interaction occurs because Viramune can affect the metabolism of these contraceptives, potentially leading to decreased blood levels and compromising their contraceptive effects.\nIt is vital to discuss this potential interaction with your healthcare provider to ensure that appropriate contraception options are used while taking Viramune. They will be able to recommend alternative birth control methods, such as barrier methods like condoms or intrauterine devices (IUDs), which are not affected by Viramune’s metabolism.\nInteraction with Hormone Replacement Therapies:\nIn addition to hormonal contraceptives, individuals who are considering hormone replacement therapies should also be aware of Viramune’s potential interactions. Similar to hormonal contraceptives, Viramune may decrease the effectiveness of hormone replacement therapies due to its influence on their metabolism.\nIt is crucial to consult with your healthcare provider to explore alternative options or strategies if you rely on hormone replacement therapies while taking Viramune. They may recommend adjusting the dosage, switching to different hormones, or exploring non-hormonal alternatives to manage menopausal symptoms.\nRemember, it is essential to have an open and honest conversation with your healthcare provider to ensure that your contraception or hormone replacement needs are met while taking Viramune.\n- For more information about HIV treatment and Viramune, please visit the National Institutes of Health.\n- To learn about alternative contraception options, the Planned Parenthood website offers comprehensive information and resources.\n- If you have questions or concerns about hormone replacement therapies, the North American Menopause Society provides reliable information and guidance.\nRemember, always consult with your healthcare provider or pharmacist before making any changes to your medication regimen or starting new supplements.\nViramune’s Interaction with Vitamins or Mineral Supplements: Recommendations and Considerations\nWhen taking Viramune, it is important to be aware of the potential interactions between this medication and certain vitamins or mineral supplements. These interactions can affect the effectiveness of Viramune and may require adjustments in dosing or avoidance of specific supplements. It is essential to consult with a healthcare provider or pharmacist before starting any new supplements to ensure optimal treatment outcomes and avoid any adverse effects.\nVitamins or Minerals that May Interact with Viramune:\n- Vitamin K: Studies have shown that Viramune can reduce the levels of vitamin K in the body. Vitamin K plays a crucial role in blood clotting, and a deficiency can lead to bleeding complications.\n- Vitamin D: Viramune has been found to decrease the levels of vitamin D in some individuals. Vitamin D is essential for bone health, immune function, and overall well-being.\n- Calcium: Viramune can also affect calcium levels in the body. Calcium is vital for maintaining strong bones, muscle function, and proper nerve transmission.\nRecommended Actions for Individuals Taking Viramune:\n- Consult a healthcare provider or pharmacist: Before starting any new vitamin or mineral supplement, it is important to discuss the potential interactions with Viramune. They can provide personalized recommendations based on your specific health needs and Viramune therapy.\n- Maintain a balanced diet: While taking Viramune, it is crucial to focus on consuming a well-rounded diet that includes a variety of nutrient-rich foods. This can help mitigate the risk of nutrient deficiencies caused by potential interactions.\n- Consider alternative sources of vitamins or minerals: In some cases, it may be necessary to explore alternative ways to obtain specific nutrients that are affected by Viramune. This may involve adjusting the diet, considering fortified foods, or exploring alternative supplementation options.\nThe Importance of Nutrient Deficiencies:\nIt is important to remember that Viramune’s potential interactions with vitamins or mineral supplements should not deter individuals from taking this medication. With appropriate guidance from healthcare professionals, individuals can effectively manage any potential interactions while reaping the benefits of Viramune in treating HIV infection and lowering the risk of developing AIDS. By maintaining a balanced diet and addressing specific nutrient deficiencies, individuals can support their overall health and well-being while undergoing Viramune therapy.\nFor more information on Viramune and its interactions with vitamins or mineral supplements, please consult reputable sources such as the HIV.gov or consult with your healthcare provider.\nInsight into the Most Significant General Health Medicines Developed (Continued)\nIn the previous sections, we explored the overview of Viramune, its importance in HIV treatment, and its potential interactions with hormonal contraceptives and supplements. Now, let’s continue our discussion on the most significant general health medicines developed and their impact on overall well-being.\nThe Importance of General Health Medicines\nGeneral health medicines play a vital role in improving people’s overall well-being. They target common health concerns that affect a large population, such as high blood pressure, diabetes, and cholesterol management. These medicines not only alleviate symptoms but also help individuals lead healthier lives.\nSignificant General Health Medicines on the Market\nSome of the most significant general health medicines available today include:\n- Blood Pressure Medications: These medications, such as ACE inhibitors and beta-blockers, are prescribed to manage high blood pressure, reducing the risk of heart disease and stroke.\n- Diabetes Medications: Metformin, insulin, and other diabetes medications help control blood sugar levels, prevent complications, and improve overall diabetes management.\n- Cholesterol-Lowering Medications: Statins, such as atorvastatin and simvastatin, are highly effective in reducing bad cholesterol levels, lowering the risk of heart disease.\n- Anti-inflammatory Medications: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen reduce pain, fever, and inflammation, providing relief to individuals with various health conditions.\n- Antidepressants: Selective serotonin reuptake inhibitors (SSRIs) and other antidepressants help manage depression and anxiety disorders, improving mental health and quality of life.\nThe Benefits for Individuals with Limited Resources\nThese general health medicines are particularly beneficial for individuals with limited resources or access to healthcare services. Affordable generic options are available for many of these medications, ensuring that people from all walks of life can afford their necessary treatments.\nSuccess Stories Showcasing Positive Impact\nCountless success stories exist, highlighting the positive impact of general health medicines on people’s lives. For example, John, a middle-aged man with high blood pressure, was able to lower his blood pressure to a healthy range and reduce his risk of heart disease with the help of blood pressure medications. Similarly, Mary, who had struggled with diabetes for years, successfully managed her condition with diabetes medications, leading a healthier and more fulfilling life.\nBy focusing on the development and accessibility of general health medicines, we can continue to make significant strides in improving the overall well-being of individuals worldwide.\n6. Potential Side Effects and Precautions of Using Viramune\nWhile Viramune is a valuable medication in the treatment of HIV infection, it is important to be aware of its potential side effects and take necessary precautions. Consultation with a healthcare provider is essential for understanding individual risks and benefits associated with Viramune use.\n6.1. Common Side Effects\nMost individuals taking Viramune may experience some common side effects, which include:\nThese side effects are usually temporary and disappear on their own as the body adjusts to the medication. However, it is crucial to inform a healthcare provider about any persistent or severe side effects.\n6.2. Severe Side Effects\nAlthough rare, Viramune can cause severe side effects that require immediate medical attention. These may include:\n- Severe rash\n- Liver problems (e.g., yellowing of the skin, dark urine)\n- Allergic reactions (e.g., difficulty breathing, swelling of the face or throat)\n- Changes in mood or mental health\nIf any of these severe side effects occur, it is crucial to seek medical help without delay.\n6.3. Precautions and Interactions\nBefore initiating Viramune treatment, individuals need to consider certain precautions:\n- Pregnancy: Viramune may harm an unborn baby, so it should only be used if clearly needed after discussion with a healthcare provider.\n- Liver disease: Individuals with pre-existing liver problems should be closely monitored while taking Viramune.\n- Drug interactions: Viramune can interact with other medications, including over-the-counter drugs and supplements. It is necessary to inform the healthcare provider about all current medications before starting Viramune.\nFurthermore, it is essential to be aware of the potential interactions between Viramune and important medications such as hormonal contraceptives or hormone replacement therapies. These interactions may reduce the effectiveness of these treatments, making it crucial to discuss alternative contraceptive or hormone replacement options with a healthcare provider.\nFor detailed information on potential interactions with vitamins or mineral supplements, individuals should consult with their healthcare provider or pharmacist. It is important to be cautious when introducing any new supplements while taking Viramune.\nAccording to the Centers for Disease Control and Prevention (CDC), it is vital for individuals taking Viramune to adhere to their prescribed treatment plan and report any concerning side effects to their healthcare provider immediately.\nIn conclusion, while Viramune is a valuable medication in HIV treatment, individuals must be aware of potential side effects and follow necessary precautions. Regular communication with a healthcare provider is crucial to ensure the safe and effective use of Viramune alongside other medications and lifestyle modifications.\nViramune’s influence on liver function and recommendations for monitoring\nOne important aspect to consider when using Viramune is its potential impact on liver function. Like many other medications, Viramune can affect the liver, and it is essential to monitor liver enzymes regularly to ensure its safe use.\nAccording to the Food and Drug Administration (FDA), Viramune has been associated with cases of severe liver toxicity, including hepatotoxicity and liver failure. Therefore, it is crucial to be aware of the signs and symptoms of liver problems and regularly evaluate liver enzymes during treatment with Viramune.\nSome common signs of liver problems to watch out for include:\n- Yellowing of the skin or eyes (jaundice)\n- Unexplained fatigue or weakness\n- Dark urine\n- Abdominal pain or swelling\n- Loss of appetite\n- Nausea or vomiting\nAdditionally, it is recommended to conduct liver function tests, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), before initiating Viramune therapy and regularly throughout the treatment.\nIf liver enzyme levels become elevated while on Viramune, dosage adjustment or discontinuation of the medication may be necessary, as advised by healthcare professionals. Prompt communication with a healthcare provider is vital to address any concerns or potential liver-related issues.\nIt is worth noting that Viramune should not be initiated in patients with moderate or severe liver dysfunction.\nFor more detailed information on the potential impact of Viramune on liver function, it is recommended to consult reliable sources such as the Centers for Disease Control and Prevention (CDC) or the World Health Organization (WHO).", "label": "Yes"}
{"text": "Thyme extract has been traditionally used in cases of productive cough associated with cold.\nThe use of thyme extract provides natural and safe support for health. The high natural essential oil content acts as a relevant quality marker ensuring activity of the ingredient to produce positive effects on health.\nThe use and safety of thyme extract as traditional herbal preparation for use to aid in productive cough associated with cold is based upon long-standing use.\nSuperior production process technology guaranties the high biological activity of IFF Health´s thyme extracts. Made in under cGMP and NSF-GMP.", "label": "Yes"}
{"text": "Colostethus atopoglossus is a species of frog in the Dendrobatidae family. It is endemic to Colombia. Its natural habitats are subtropical or tropical moist montane forests and rivers. It is threatened by habitat loss.\n- Grant, T. & Castro, F. 2004. Colostethus atopoglossus. 2006 IUCN Red List of Threatened Species. Downloaded on 21 July 2007.\n|This poison dart frog article is a stub. You can help Wikipedia by expanding it.|", "label": "Yes"}
{"text": "GeneNews Announces Issuance of Second Foundational U.S. Patent for Sentinel Principle® Technology\nNews Feb 17, 2010\nGeneNews Limited has announced that it has been granted a second U.S. patent for its core platform technology, the Sentinel Principle®. U.S. Patent No. 7,662,558, entitled \"Method of profiling gene expression in a human subject.\"\nThe patent covers the application of the Sentinel Principle® in any health management context, including diagnosis, staging of disease, drug testing, monitoring response to treatment and biomarker screening.\n\"We believe that the Sentinel Principle® has the potential to change the way that medicine is currently practiced,\" said Gailina Liew, President & Chief Operating Officer of GeneNews.\n\"The issuance of this second U.S. patent significantly expands the scope of protection for this ground-breaking approach to identify clinically actionable biomarkers. It also enhances GeneNews' ability to realize additional commercial value through potential licensing arrangements, the pending issuance of additional patents which cover biomarker panels for specific clinical indications, and the continued development of our own pipeline of 'Sentry' products,\" Liew said.\nThe Sentinel Principle®, a platform technology discovered and developed by GeneNews, is based on the concept that all clinical conditions and body states, including those resulting from disease or in response to treatment, generate characteristic gene expression signatures in the blood as a result of the constant and dynamic physiological interaction of blood with the cells, tissues and organs of the human body. This technology is the basis of GeneNews' initial product, ColonSentry™.\nTest For Designer Drugs Could Help Treat Overdose PatientsNews\nMedical professionals are scrambling to meet the growing demand for emergency room treatment, but they’re hampered by the lack of a quick and easy test to screen patients for “designer” drugs. Chemists have now developed such a test and are refining it with the hope that hospitals could eventually use it to choose the appropriate treatment.READ MORE\nLargest Genetic Study of Osteoarthritis Advances ResearchNews\nOsteoarthritis is a complex disease, and the genetic basis of the disease has proved difficult to pin down. A new study from the Sanger Institute provides much-needed hope.READ MORE\nComments | 0 ADD COMMENT\n11th International Conference and Exhibition on Metabolomics & Systems Biology\nMay 17 - May 19, 2018\n6th Annual Congress on Biology and Medicine of Molecules\nSep 17 - Sep 18, 2018\nWorld Congress on Pathology and Laboratory Medicine\nSep 10 - Sep 11, 2018", "label": "Yes"}
{"text": "All along the east side of my back garden is a row of shrub rose of variety \"Knockout\". The wooden fence is 5 feet high and the rose is nearly to the top. Knockout is a fairly new variety, extremely disease resistant, vigorous, and long blooming. I planted these about 5 years ago and they have grown to an impenetrable wall of thorn and bloom. Even Smokey is reluctant to crash through to bark at the neighbor's lawn mower.", "label": "Yes"}
{"text": "Malignant bilateral cialis para que sirve pheochromocytoma and von Recklinghausen disease Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. Hippocampal learning, memory, and neurogenesis: Effects of sex and estrogens across the lifespan in adults.\nFeline ADH has lower enzymatic capacity for turnover or is less concentrated in liver than canine ADH with regard to EtOH and EG catalysis. NOTES ON THE TEMPERATURE IN A CASE OF ADVANCED PULMONARY TUBERCULOSIS.\nThis article reviews its safety under different therapeutic requirements and applications in both allogeneic and autogenous tissue reconstruction. Perforation of the necrotic wall had occurred in all foals, leading to acute cialis rezeptfrei fibrinous peritonitis.\nWhen prescribing mannitol to decrease intraocular pressure, the physician must cialis pills be alert to potential complications. Furthermore, observations are viewed on the effects of selenium compounds on spontaneously developing, chemically or virally induced tumors.\nThe patient in Case cialis tablets australia 3 is having some seizures 3.5 years postsurgery and remains hemiplegic, but the regression has reversed and she is making steady developmental progress. Validation and test-retest reliability of Early Trauma Inventory in Spanish postpartum women.\nThe results critically depend on homogeneity and consistency assumptions, which are sometimes difficult to investigate. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does cialis sans ordonnance livraison 48h not show overall beneficial effects.\nModerate antimicrobial activities cialis tablets were observed for the studied apple cultivars. Expression of human HSP70 during the synthetic phase of the cell cycle. The contrast sensitivity measurement was performed both individually for each eye and in a binocular fashion using the Pelli-Robson Sensitivity Chart.\nThe plasticity of plant phenotypes cannot be simply explained by genetic changes such as point mutations, deletions, insertions and gross chromosomal rearrangements. Future developments of the industrial gamma ray CT will be focused on a large-scale application which is more practical cialis vs viagra for a diagnosis in the petrochemical industry. Multiple fractions were assayed by LC-MS/MS to detect the presence of SEM.\nbeta2m affects bone metabolism by mechanisms that include increasing IL-6 gene expression and release, and enhancing osteoblast proliferation without affecting osteocalcin cialis online gene expression. We report here the construction of quinolizidine ring systems by intramolecular cyclization of suitable functionalized piperidines via a reductive amination sequence.\nIncreased binding cialis generika preis of tumor cells by macrophages activated in vitro with lymphocyte mediators. To a large degree these types of studies have been limited in the past due to the lack of an appropriate experimental system.\nDevelopment of flow-through and dip-stick immunoassays for screening of sulfonamide residues. Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray. What is cialis medication the optimal pharmacological management of retained placenta?\nThis phosphopleckstrin-mediated inhibition is overcome by increasing concentrations cialis sans ordonnance of Gbetagamma. Parathyroid hormone and calcium are independent correlates of cortical density, and modifiable factors for fracture include parathyroid hormone and phosphate binder use.\nWe report the cialis prices results of a study on 29 patients affected by renal chronic insufficiency and treated with high doses of muzolimine. Using a high pressure homogenizer or an ultrasonic procedure resulted in the formation of microspheres with homogeneous protein distribution and a reduced burst release.\nFGF2, which promotes mouse OPC generation, inhibits the transition of pre-OPCs to OPCs by repressing SHH-dependent co-expression of OLIG2 and NKX2.2. Study of pathogenetic mechanisms of cialis générique intoxication in patients with anaerobic non-clostridial infection\nThe method employs the polymer reference interaction site model for the intermolecular correlations and the Green function technique for the intramolecular correlations. Fire in the mind: changing understandings of fire in Western civilization. A citizen point of view on the healthcare system, its processes and their improvement is cialis side effects emphasised.\nRatio of spleen diameter to red blood cell distribution width: a novel indicator for celiac disease. These findings are similar to those in other studies of cialis générique pharmacie en ligne the life span of guidelines.\nCondensed tannins, present in cotton mill dust, alter the host-defense function of alveolar macrophages and may contribute to the pathogenesis of byssinosis. Sustained evaluation and support seem to be a cialis genérico vital tool in integrating a volunteer project into a health team approach.\nAt 18 months cialis on line the patient continues to have a normal voice and normal laryngeal development. The lattice constants of the pure WZ GaP obtained from the TEM images agree with values determined previously by x-ray diffraction from non-pure NW ensembles. Qualitative data from focus group sessions were used to assess health care professional and patient perceived usability and value of the Asthma APGAR tools during office visits for asthma.\nThree methods of estimating births averted nationally by contraception. In this respect an adequate freeze-drying technique is essential, whereas the question of cialis vs viagra comparison protective media appears to be of less importance.\nHypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia. The detection method ELISA specific for estradiol, revealed the expression of this estradiol-related molecule in schistosome worm extracts, but not in Fasciola hepatica worm extracts. Furthermore, the loss cialis kopen zonder recept of THBS1 inhibited in vivo motility of melanoma cells within the embryonic chicken neural tube.", "label": "Yes"}
{"text": "Publisher: Elsevier Science\nPublication Date: October 09, 2015\nBinding: Kobo eBook\nAquafeed Formulation is the only resource that provides summaries with examples and formulation techniques specifically to meet the needs of anyone in the aquaculture industry.\nAs feed is the largest single cost item in aquaculture production, and formulating aquaculture feed requires many combinations of several ingredients and nutrient requirements, this book takes a clear-and -concise approach, providing essential information on formulation and covering relevant available software, feed nutrients, and additives such as enzymes and phytase and conjugated fatty acids, as well as best industry practices to improve aquafeed production.\nUsers will find this to be a one-stop resource for anyone interested or involved in, the global aquaculture industry.", "label": "Yes"}
{"text": "Good Oscar fish care starts with learning as much as you can about the special requirements of this beautiful and much sought-after tropical freshwater fish.\nThe Oscar fish, sometimes referred to as the Velvet Cichlid, Red Oscar or Tiger Oscar, is a tropical freshwater fish that originated in South America. Their coloration varies according to their mood, but most have orange or red patches on a dark green, brown or black background.\nThey grow very large, up to 14 inches long. Don’t be fooled by their small size in the pet store tank. This means that you’ll need a large aquarium to house them – at least a 55 gallon aquarium for a single fish and at least a 90 gallon aquarium for a pair.\nWhen setting up the aquarium, try to buy gravel that is cichlid safe. And put enough gravel on the bottom of the tank to hold down any decorations. Real plants will be uprooted and eaten, so fake plants are recommended.\nAn undergravel filter system is not recommended, as they like to chew on everything in their tank. It’s also recommended that you keep an eye on your heater. They just might start chewing on it too. If so, you should buy a heater guard or find a barrier to put around it.\nOscars like to have plenty of hiding places, so you can provide driftwood, rocks, flowerpots or other structures to accomplish this.\nAs with all aquariums, set up your aquarium and let it age before introducing your Oscar to it. The nitrogen cycle needs time to complete, and this process takes anywhere from 2 weeks to a month. You can speed up this process by adding filter media, water and/or gravel from an already established tank to your new setup. If you don’t have another aquarium, you can add a little bit of flake food each day to your aquarium and this will begin the nitrogen cycle. Buy a testing kit from your local pet store so you’ll know when the cycle is completed.\nOscars will eat just about anything and it’s good to give them variety in their diet. You should feed them a base of quality cichlid pellets. And supplement this with regular feedings of freeze-dried worms, peas, lettuce, and brine shrimp. Some people even feed their cichlids hot dogs and hamburger meat.\nBecause Oscars are so big, they create a lot of waste. So you’ll need plenty of filtration to clean your large Oscar aquarium. At least two high-powered filters are absolutely essential. When filtering Oscar tanks, there’s no such thing as overkill. If you have a 90 gallon tank, then you want filters that will combine to filter more than a 90 gallon tank.\nOscars are fairly hardy fish that can live 10 years. They’ll do well in a temperature range of 70 to 80 degrees Fahrenheit and tolerate a wide range of pH and water hardness levels.", "label": "Yes"}
{"text": "hCG levels during pregnancy | Amazing Pregnancy\n6 weeks pregnant – all you need to know | Tommy’sIn fact, it is the hormone detected in the urine by at-home pregnancy tests.HCG levels, the hormone detected in home pregnancy tests and blood tests, can vary widely from day to day, person to person, and even pregnancy to pregnancy.\nHCG levels at 6 weeks? - BabyGagaEven if the levels are on the lower side, as long as they are doubling every 48 to 72 hours everything should be fine.\nFAQ: 2-Week Wait | Shady Grove FertilityBy the end of this week your baby will have grown to the size of an orange pip.\nHuman chorionic gonadotropin, or hCG, is a hormone produced during pregnancy in the cells of the placenta.Here is the normal range of this hormone during different weeks of pregnancy to help you understand the result.I saw my GP on Monday about this and she took blood to measure my HcG levels.My HCG level at what was supposed to be 6 weeks 1 day was only 98.\nThis relies on the growth of the normal fetus of 1 mm per day after the 6th week of gestation.Doctors use hCG levels to determine pregnancy and the stage of pregnancy.I will be glad to answer the follow up queries that you have.HCG is used in determining the pregnancy even before the pregnant woman starts to show any symptoms or signs of the pregnancy.\nHCG levels – 10 Things You Need To Know | Your IVF JourneyI went into the doctor on September 10th, excited and nervous to get a confirmation.It must be taken into account, however, that total hCG levels may vary in a very wide range within the first 4 weeks of gestation, leading to false results during this period.\nAfter a pregnancy is terminated by delivery or abortion, blood and urine hCG levels gradually decrease.Hi there, last week I was 7 weeks pregnant and HCG levels measured 3090.\nYour pregnancy at 5 weeks - Medical News TodayThis report is normal and is suggestive of a normal viable pregnancy.If you are concerned, perhaps your doctor can perform an ultrasound to confirm the heartbeat of the baby and your due date.Read more Read more.\nHCG Weeks - Conceiving ResourceThe level will reach its peak at around 8-11 weeks of pregnancy and then will.Any abnormal value could indicate a problem which would lead to further. read more.\nHCG level with twins??? | DailyStrengthBeta hCG Doubling Calculator Calculate the doubling time of two beta hCG test results.If I remember correctly, he said that my level (at 6 weeks pregnant) was 400 something.Since normal levels of HCG can vary tremendously, after 5-6 weeks of pregnancy, sonogram findings are much more predictive of pregnancy outcome than are HCG levels.\nOnce the gestational sac is seen, most doctors will monitor with ultrasounds rather than drawing HCG.The alpha subunit is similar to those of luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone.Learn what ranges are considered normal for your week of pregnancy.One first semester genetic test combines a blood test with an ultrasound to screen for Down syndrome may be available between 11 and 14 weeks of pregnancy.", "label": "Yes"}
{"text": "The use of enzymes in textile industry is one of the most rapidly growing field in industrial enzymology. The formula helps to reduce the complex nutritional components of food, digesting proteins, lipids and complex carbohydrates to allow for optimal absorption. This is the first detailed investigation that concerns the characterization of catalytic properties and sequence identity of enzymes with. Because enzymes are relatively large molecules, separation based on the size or mass of molecules favors purification of enzymes, especially the ones with high molecular weight. Recombinant enzymes enzymes are large biological molecules responsible for the thousands of metabolic processes that sustain life. The function of enzymes is described as their ability to catalyse biochemical reactions according to the enzyme commission ec. Enzyme replacement therapy ert is a medical treatment which replaces an enzyme that is. A naturopathic approach to breast cancer semantic scholar. Enzyme biotechnology related to isolation, extraction, purification of enzymes pharmatutor. Some biological reactions in the absence of enzymes may be as much as a million times slower 32.\nEnzymes 3d structure enzymes are proteins and their activities depends on the 3d structure of the amino acids that compose them note. Viscozyme l background multienzyme complex containing a wide range of carbohydrases, including arabanase, cellulase. V enzymes is a benchmark vegan digestive support product. Eleven different soil samples were taken for isolation of lipase producing organisms under laboratory condition. Find, read and cite all the research you need on researchgate. With the assistance of a coauthor, this popular student textbook has been updated to include techniques such as membrane chromatography, aqueous phase partitioning, engineering recombinant proteins for purification and due to the rapid advances in bioinformatics. The curve of initial velocity versus s for allosteric enzymes is not. English information brochure about horvi enzyme therapy. Enzymes may show a high specificity toward one substrate or exhibit a broad specificity, using more than one substrate. Enzymes ec classification concerted model of catalysis ec 1, oxidoreductases. Enzymes can be altered by temperature and by the acidity of the environment. Purification and characterization of enzymes exhibiting. Dialysis is a commonly used method, where semipermeable membranes are used to remove salts, small organic molecules, and peptides figure 2. Enzymes are proteins that are found in all living organisms.\nAn enzyme is a protein that functions as a catalyst to speed up a chemical reaction in the body. There are mainly three major purification methods depending on the technique or property of enzyme. Introduction to enzymes the following has been excerpted from a very popular worthington publication which was originally published in 1972 as the manual of clinical enzyme measurements. The extraction methods are followed by the purification processes.\nEnzymes are manufactured in bioreactors for commercial use. It is important to study enzymes in a simple system only with small ions, buffer molecules, cofactors, etc. Enzymes are protein catalyst produced by a cell and responsible for the high rate and specificity of one or more intracellular or extracellular biochemical reactions. Vortragsbeschreibung thptage 2014 tierheilpraktikertage. Horvi naturheilkunde bestellen bioapo versandapotheke. Almost all enzymes are globular proteins consisting either of a single polypeptide or of two or more polypeptides held together in quaternary structure by noncovalent bonds. Enzymes application in diagnostic prospects author. In general, there are four distinct types of specificity. Fatal invasive cervical cancer secondary to untreated cervical. In recent years, there have been considerable developments in techniques for the investigation and utilisation of enzymes. Horvienzymtherapie lugen sind unser geschaft psiram. Enzymes execute of two basic functions in biological object. However, due to transit disruptions in some geographies, deliveries may be delayed. Nomenclature avant 1961, les enzymes ont ete denommees selon le nom du s sur lequel elles agissent en ajoutant le suffixe ase.\nEnzymes can be defined as the complex organic catalysts produced by living cells but capable of acting independently of cells that produce them. Enzymes do nothing but speed up the rates at which the equilibrium. Enzymes are proteins and their activities depends on the 3d structure of the amino acids that compose them note. This work describes the purification and characterization of enzymes that exhibit. Leur comportement est non michaelien effet cooperatif. Methods of purification of enzymes biotech articles. This dissertation explores aspects of the chemistry and evolution of a small class of enzymes catalysing geometrical and structural rearrangements between isomers, the. Six major classes of enzymes and examples of their subclasses.\nFor example, the food that you eat is broken down by digestive enzymes into tiny pieces that are small enough to travel through your blood stream and enter cells. Because enzymes function in cells, the optimum conditions for most enzymes are moderate temperatures. Enzymes are compounds that assist chemical reactions by increasing the rate at which they occur. Pdf a large amount of wastes are generated every year from the industrial processing of agricultural raw materials. Enzymes usually function within a moderate ph and temperature range.\nIn addition, this product interferes with the enzyme. Wolfenbuttel therapien heilpraktiker markus pretzsch. Pdf amyotrophic lateral sclerosis als is a neurodegenerative disease characterized by selective death of motor. These products have applications in both cleaning and water treatment. Vi industrial uses of enzymes michele vitolo encyclopedia of life support systems eolss bakery. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Texas prior authorization program clinical criteria drugdrug. Nelson, lehninger principles of biochemistry, iv edition, w. Enzymes are subjected to regulation, to adapt to the requirements of different cells. In spite of the role of the microbial cells in the fermentation process was well established by pasteur in 1876, the enzymatic mechanisms began to be understood only. Treatments that have been claimed to be of benefit in ms. The rate is not zero at 0c, so enzymes still work in the fridge and food still goes off, but they work slowly. These enzymes are in the crude form and have to be purified for further use.\nEnzymes may be used in bioprocessing to carry out rapid conversions of their substrates at moderate temperatures and near neutral ph, usually with high specificity towards substrate selection in a complex mixture and with respect to the actual nature of the chemical conversion. There exist positive experiences in the treatment of gilbert syndrome, especially acquired gilbert syndrome if you acquired gilberts syndrome through heavy metals and did not originally have it from birth. Allosteric enzymes are those modulated by agents that bind to them at a site different to the active center. Microbial enzymes have a great number of usein food, s pharmaceutical, textile, paper, leather and other industries hasan, et al. Enzymes are biological catalysts responsible for supporting almost all of the chemical reactions that maintain animal homeostasis. Enzymes can even work in ice, though the rate is extremely slow due to the very slow diffusion of enzyme and substrate molecules through the ice lattice. Absolute specificity the enzyme will catalyze only one reaction.\nThe enzymes used in the textile field are amylases, catalase, and laccase which are used. A diet similar to the evers diet, supplemented with plant and bacterial enzymes, normal digestive. When the s in the cell is below the k m, changes in s modify the activity. The history of the enzyme treatment of cancer alternative. They change the shape of the enzyme so that it either doesnt accept a molecule, or so that it accepts it more slowly. Enzyme biotechnology related to isolation, extraction. Clinical prior authorization the following clinical prior authorizations have been implemented for medicaid members, consistent with the vendor drug program. Industrial uses of enzymes encyclopedia of life support. Enzymes are involved in conversion of substrate into product. All authors read and approved the final manuscript. The biological catalysts of life pekka mantsala and jarmo niemi encyclopedia of life support systems eolss generally, an increase in temperature increases the activity of enzymes. While some of the presentation may seem somewhat dated, the basic concepts are still helpful for researchers who must. Group specificity the enzyme will act only on molecules that have specific functional groups, such as amino, phosphate and methyl groups.1481 922 1230 113 1140 678 1480 991 943 497 1017 1512 887 1569 1098 1390 1276 894 1323 59 1179 325 1296 1141 469 205 1143 230 184 166 507 431 616 1359", "label": "Yes"}
{"text": "My point is, I was always afraid to try these beautiful plants. I thought they would be to hard to grow . Thanks to the internet and great sites like this one you can’t go wrong. I am so happy I bought my first one, I am a complete addict now! Just be sure you look at the roots before you buy, not the flowers and never let the bottom of your inner pot sit on the ‘floor’ of the exterior vase, I line mine with fish tank rock. I live in AZ where humidity is nonexistent so I run a small fan for my flowers as well to help with humidity as well as air flow.\nOrchid flowers primitively had three stamens, but this situation is now limited to the genus Neuwiedia. Apostasia and the Cypripedioideae have two stamens, the central one being sterile and reduced to a staminode. All of the other orchids, the clade called Monandria, retain only the central stamen, the others being reduced to staminodes (4). The filaments of the stamens are always adnate (fused) to the style to form cylindrical structure called the gynostemium or column (2). In the primitive Apostasioideae, this fusion is only partial; in the Vanilloideae, it is more deep; in Orchidoideae and Epidendroideae, it is total. The stigma (9) is very asymmetrical, as all of its lobes are bent towards the centre of the flower and lie on the bottom of the column.\nHello I got my orchid of the street. I think it’s about 2 feet tall and it is buttifull and blumming ever since I got it but I have no idea how to care for it b/c my parents have no Idea either, I’ve lost count of how many things there doing wrong but there really busy with other stuff around the house but I think it’s a Phalaenopsis it would reply help if you could tell me what to do\nAnguloa, the Tulip Orchid, is well described by its common name! They have substantial, tulip-shaped flowers in shades of white, green, yellow, and red. They like a lot of humidity, intermediate-to-bright light, and cool-to-intermediate temperatures. They really like humidity and hate drying out during the growing season, but most need a dry rest after flowering.\nThis is not a type of orchid you’ll want to place on your windowsill, because the stems grow up to four feet high. Phaius orchids have large, strappy leaves, and they usually produce petals that are yellow, purple, or white. Also known as the Nun’s Cap orchid, it is a winter bloomer and makes a great addition to anyone’s garden, regardless of what else is planted there.\n^ Zhang, Guo-Qiang; Liu, Ke-Wei; Li, Zhen; Lohaus, Rolf; Hsiao, Yu-Yun; Niu, Shan-Ce; Wang, Jie-Yu; Lin, Yao-Cheng; Xu, Qing; Chen, Li-Jun; Yoshida, Kouki; Fujiwara, Sumire; Wang, Zhi-Wen; Zhang, Yong-Qiang; Mitsuda, Nobutaka; Wang, Meina; Liu, Guo-Hui; Pecoraro, Lorenzo; Huang, Hui-Xia; Xiao, Xin-Ju; Lin, Min; Wu, Xin-Yi; Wu, Wan-Lin; Chen, You-Yi; Chang, Song-Bin; Sakamoto, Shingo; Ohme-Takagi, Masaru; Yagi, Masafumi; Zeng, Si-Jin; et al. (2017). \"The Apostasia genome and the evolution of orchids\" (PDF). Nature. 549 (7672): 379–383. doi:10.1038/nature23897. PMID 28902843.\nI think flying with the plant would be a challenge. Could you purchase one when you get there? Also, you need to check about bringing live plants into Spain because they have different rules for different countries. If you are giving the gift of a keiki or a cutting, that can be really challenging to grow for a beginner as well. So I’m not sure if that’s the best option. Honestly I think your best option is to contact this society and ask them what reputable growers they would recommend. I hope this helps! – Mary Ann\nSpecial thanks to David Banks of Australia, Christian Kirsch; Dr. Rudolph Jenny, Peter O'Byrne***, Eric Hagsater***, Lisa Thoerle***, Mario Blanco***, Mark Whitten***, Adam Karremans, Hakan Halander****; Daniel Jimenez***, André Schuiteman***, Dr. E.F. de Vogel, Jaap Vermeulen, Rick Barry, Dr. Guido Braeme, Rogier Van Vugt; Rene Dishong, Tom Ballinger, Mac & Helen Rivenback; Dr Rubin Salueda; Rafael Govaerts***, Padre Pedro Ortiz, Dr Leslie Garay, Vena Read, Charles Lamb, Donald Tan of Malaysia, Joseph Dougherty, Dalton Holland Baptista, Rick Cirino; Prem Subrahmanyam, ROMAN MARUSKA Czech Republic, Michael Coronado, Alejandro Taborda, Greg Butler and Oak Hill Gardens, Bill Bergstrom and Bergstrom Orchids, Donna Nash, Oliver Lenhard, D. E Vermeullen, Americo Docha Neto, Richard Korber, Carl Withner, Mark Nir, Ekkehard Schwadtke; Dr Eric Christenson, Dave Alford, Igor Zhuravlev, Tony Watkinson, David Hunt, Jean Marie Vanderwinden, Glen Ladnier, Jeffrey W. Tucker, Jorge Alejandro Paulete Scaglia, Scott McGregor, Wilella Stimmell, Eric Thiessen, Geert Volckaert, George and Kathy Norris***, David Alford, Eric Hunt, Peter O'Byrne, Allen Black, Helen Milner, Al Pickrel, Greg Riemer, Marcia Whitmore, Phillipe Musschoot, Wilford Neptune, Jean-Claude George, Tony Walsh, Greg and Kerri Steenbeeke and their Orkology Kreations Website, Jim Hamilton, Robert Fuchs and RF Orchids, Gene Monier and JEM Orchids, Jerry Bolce, Andy's Orchids, Stephen Jones, First Ray Orchids, Robert Weyman Bussey, JEM Orchids, Carlos Hajek and his Peruvian Orchid Page, Bill Morden, David Morris, Noble Bashor, Patricia Harding, Nina Rach, David Haelterman; Craig Cooper, Rocky Giovinazzo, David Friedman, Bill Pinnix, Troy C. Meyers, Linda's Orchid Page, Pierre-Alain Darlet*, Guy Cantor, Tropical Orchid Farm in Maui, H&R Nursuries, Lois Greer, Ichiro \"Haru\" Ohsaka and his Bulbophyllum Page, Mauro Rosim from Brazil, A World Of Orchids, Bruce Norris of Canada, Nick Doe, Neville De La Rue, Nelson Barbosa Machado Neto, Jeff Aguillon, Dale and Deni Borders, Eka Mulja Tjipta, Rick Barry, Manfred Schmucker, Uri Baruk, Mike and Candy Joehrendt, Dan and Marla Nikirk, Walter Orchard, Christer Carlson; Guillerrmo Angulo, M. Max, Paula Vagner, Tennis Maynard, Greg Allikas, Malcolm Thomas, David Morris, Jacques Deschenes, Lourens Grobler; Gary Yong Gee; José Castaño Hernández; Judd and David Janvrin* for their photo and text contributions.\nOrchids have become very popular houseplants in recent years, with their delicate blooms adding elegance and allure to any room. But for beginners, knowing how to water orchids may seem a bit daunting, since they are unlike other common houseplants. This article is going to focus on how to water phalaenopsis orchids. These are also called moth orchids, and are one of the most popular and widely available varieties of orchid.\n^ Thomas J. Givnish, Daniel Spalink, Mercedes Ames, Stephanie P. Lyon, Steven J. Hunter, Alejandro Zuluaga, William J.D. Iles, Mark A. Clements, Mary T.K. Arroyo, James Leebens-Mack, Lorena Endara, Ricardo Kriebel, Kurt M. Neubig, W. Mark Whitten, Norris H. Williams, and Kenneth M. Cameron. 2015. \"Orchid phylogenomics and multiple drivers of their extraordinary diversification\". Proceedings of the Royal Society, series B (biological sciences) 282(1814):pages??. doi:10.1098/rspb.2015.1553.[full citation needed]\nOrchids come in different sizes. I have a miniature phal in a 3-inch pot. This orchid needs watering more often than the larger ones in 6″ deep pots. An orchid in a larger pot will need watering less often, but will need more water quantity wise. The material of the pot will also make a difference. Those in plastic will dry out a bit slower than those planted in porous terra cotta.\nCatasetum orchids, along with the other members of the Catasetum alliance, have big, thick pseudobulbs with an attractive fan of thin leaves along their length. The flowers can be very showy, but are unisexual, so that male and female flowers look different. Lighting affects which kind appears. They need a dry rest after flowering when the leaves drop.\nOrchids of all types have also often been sought by collectors of both species and hybrids. Many hundreds of societies and clubs worldwide have been established. These can be small, local clubs, or larger, national organisations such as the American Orchid Society. Both serve to encourage cultivation and collection of orchids, but some go further by concentrating on conservation or research.\nHorticultural techniques have been devised for germinating orchid seeds on an artificial nutrient medium, eliminating the requirement of the fungus for germination and greatly aiding the propagation of ornamental orchids. The usual medium for the sowing of orchids in artificial conditions is agar agar gel combined with a carbohydrate energy source. The carbohydrate source can be combinations of discrete sugars or can be derived from other sources such as banana, pineapple, peach, or even tomato puree or coconut water. After the preparation of the agar agar medium, it is poured into test tubes or jars which are then autoclaved (or cooked in a pressure cooker) to sterilize the medium. After cooking, the medium begins to gel as it cools.\nNow that we’ve laid out the general guidelines, we will explore the ins and outs of how to water phalaenopsis orchids by answering some of the questions you’re sure to have if you are new to the world of these intriguing plants. So read on to learn about different aspects involved in understanding how to water phalaenopsis orchids to encourage healthy growth and prolific flowering!\nThe type of potting medium being used can also affect your plant's water requirements. Bark has a tendency to dry out more rapidly than sphagnum moss, for instance. It is important to remember, however, that even when the surface of your pot is dry, the root area may remain moist. Poke your finger or a regular wooden pencil an inch into the pot; if it feels moist to the touch or if the pencil looks moist, do not add additional water. The potting medium should always be damp, but not soggy—neither should it be allowed to get extremely dry.\nAlso known as the Moth orchid – which is much easier and less cumbersome to pronounce – this orchid is great for beginners because it is easy to grow and maintain. Appearing in lovely colors such as yellow, light pink, and spotted with burgundy, the Moth orchid blooms on and off throughout the year and can tolerate repotting efforts – again, making them a great plant for those who are new to planting flowers in their garden. They have long-lasting flowers and look great as an indoor plant, which are a few of the reasons why they are one of the most popular types of orchids.\nIt has come to my attention that some of you have been using photos or descriptions lifted from this site to aid in selling plants. Please be advised that we do not allow this and will prosecute offenders. Any reuse of these photos for commercial gain is patently illegal. All the photos of mine and my contributors are copyrighted and we will pursue offenders vigorously!\nThis type of orchid has over 200 species and has a star-shaped appearance. Most of them have small- to medium-sized blooms and come in colors such as yellow, white, or light green, although most of them are white. The flower has a wonderful fragrance, needs even amounts of water, and prefers temperatures between 60 and 80 degrees Fahrenheit, mainly because they are not a bulb plant and therefore cannot store water. They also look beautiful in hanging baskets and pots.\nSome saprophytic orchid species of the group Gastrodia produce potato-like tubers and were consumed as food by native peoples in Australia and can be successfully cultivated, notably Gastrodia sesamoides. Wild stands of these plants can still be found in the same areas as early aboriginal settlements, such as Ku-ring-gai Chase National Park in Australia. Aboriginal peoples located the plants in habitat by observing where bandicoots had scratched in search of the tubers after detecting the plants underground by scent.[Note 1]\nMost orchids are not heavy feeders. Many orchids bloom year after year with no fertilizer at all. During active growth, when new leaves are being produced, you may fertilize every other time you water at half the strength recommended on the fertilizer package. However, it's important to deliver water without fertilizer at least once a month to flush excess fertilizer salts from the bark mix and avoid fertilizer burn to the roots.", "label": "Yes"}
{"text": "AA amyloidosis resembles mad cow disease. A misfolded version of a protein converts normal proteins into abnormal ones, until large deposits of damaging protein build up in tissues -- the spleen and liver in the case of AA amyloidosis, the brain and central nervous system for mad cow disease.\nAA amyloidosis is not caused by a bacteria or virus, but it can likely spread from animal to animal like an infectious disease. Biologists have had difficulty, however, figuring out how the disease moves from cat to cat.\nFolks, cheetahs are one of my absolute favorite animals, probably for the same reason that Flash is my favorite comic book super hero. I am fascinated with speed, and that’s also one of the reasons I have been a runner for over 40 years.\nIt is such a miracle to see a cheetah engaged in a full-out sprint, and it amazes me every time I see them perform this magical feat, reaching speeds of up to 70 mph.\nMy strong suspicion that the primary reason why cheetahs are dying in captivity is that the zoo keepers are clueless about their nutritional requirements. They are likely focused on total calories, vitamins, minerals, fat and carbs, and are missing the most significant aspect of most wild animals diets.\nThey need RAW food.\nTake away the raw food and you disrupt nearly every important biochemical pathway in their body -- an absolute prescription for disaster.\nUnfortunately, American scientists and researchers are ignorant about this important aspect of health. However, many savvy German and European researchers are exploring this in the form of biophoton research which, in my eyes, is one of the most exciting areas of biomedical research.\nSunlight – Food for Your Biophoton Field\nSunlight is vital. Without the sun it is virtually impossible for most life forms to exist. I am sure you’ve noticed what a revitalizing effect sunlight has on your body and spirit, especially after a long winter, when you enjoy the first rays of the spring sun.\nBut you can absorb sun energy via your food as well as through your skin. We are in fact human photocells, whose ultimate biological nutrient is sunlight.\nDr. Johanna Budwig from Germany has stated that live foods are electron-rich, and act as high-powered electron donors and “solar resonance fields” in your body to attract, store, and conduct the sun's energy in your body. The greater your store of light energy, the greater the power your overall electromagnetic field, and consequently the more energy is available for healing and maintenance of optimal health.\nWhat are Biophotons?\nStored sun energy finds its way into your cells via food in the form of minute particles of light. These light particles are called 'biophotons', which are the smallest physical units of light.\nThey contain important bio-information, which controls complex vital processes in your body. The biophotons have the power to order and regulate, and, in doing so, to elevate the organism – in this case, your physical body -- to a higher oscillation or order.\nThis is manifested as a feeling of vitality and well-being.\nEvery living organism emits biophotons or low-level luminescence (light with a wavelength between 200 and 800 nanometers). It is thought that the higher the level of light energy a cell emits, the greater its vitality and the potential for the transfer of that energy to the individual which consumes it.\nThe more light a food is able to store, the more nutritious it is.\nNaturally grown fresh vegetables, for example, and sun-ripened fruits, are rich in light energy. The capacity to store biophotons is therefore a measure of the quality of your food.\nSo, What’s the Take-Home Message for You?\nEat MORE raw live food in your diet.\nMy personal goal is 85 percent. Unless I’m traveling, I am almost always over 50 percent, and typically around 85 percent. And yes, that includes animal proteins, as I am a protein type.\nNot all raw foodists are vegetarians or vegans. I know eating raw meat sounds extreme, but it is my belief that, like the cheetah, that is the way we were designed to eat, and as long as you buy fresh authentically organic meat, and prepare it with care on a clean surface, it is perfectly safe to consume raw. If you veer very far away from that you are bound to have complications, just like the cheetahs in captivity.", "label": "Yes"}
{"text": "By Sukuoluhle Ndlovu\nThe National Blood Services of Zimbabwe (NBSZ) is calling upon blood donors of all blood types to make a lifesaving donation following the low recording of the country’s blood bank.\nCovid -19 has hugely affected blood donations and a few blood donors are coming in to donate.\nIn a press statement released by NBSZ, the Communications Officer, Ephraim Mubayi said there are now reduced numbers of donations coming in.\n“NBSZ is urgently appealing for blood donors of all blood groups to come forward and make that life saving donation as the blood stocks for are critically low. The Covid -19 pandemic has created challenges that have impacted on blood stocks globally and Zimbabwe has not been spared.\n“It is hard to underscore how damaging the one –two punch of Covid -19 and the lockdown measures have been on the blood bank. It is not due to more patients needing blood products but rather it is reduced numbers of donations coming in,” he said.\nThe NBSZ daily stock requirements nationally is 315units of blood hence the call for donors who are due or new healthy members of the community to come forward and make a life saving donation.\nAs from tomorrow, blood donors are being urged to come forward and all NBSZ clinics will operate from 0800 to 1700hours.", "label": "Yes"}
{"text": "Botanical: Miscanthus sinensis 'Malepartus'\nCommon: Ornamental Grass\nGeneral Characteristics: Ornamental Grasses are gaining in popularity all over the U.S. due to their undemanding nature and long lasting, year round beauty. There is nothing that adds such interesting forms, textures and movement to a garden, than with this diverse plant group. They can be planted along banks of ponds, incorporated into perennial gardens, grouped together, utilized as a ground cover along walkways, paths or on steep banks. They aren't fussy about soil requirements, are drought tolerant as well as insect and disease resistant.\nTip: Plant bareroot plants only in late spring to early summer when the soil is warm, about the same time you plant your bean or corn seeds. The roots will grow only in warm soil. Planting too early in the spring may cause the roots to rot. Similar story in the fall when the roots may not grow enough to establish before the cold and wet of winter, resulting in the death of the plant.\nBecause we enjoy the foliage of Miscanthus so much, we like to leave it standing until the new growth starts to appear—possibly as late as May—before we cut it back. We also like the combination of the tan foliage and spring bulbs. Cut back to about 6\" from the crown of the plant.\nUse: Specimen, border, screen, hedge, background plant, massing, by the water, arrangements.", "label": "Yes"}
{"text": "A stem cell niche dominance theorem\n1 Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany\n2 Stellenbosch Institute for Advanced Study (STIAS), Stellenbosch, South Africa\n3 Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, USA\n4 Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, USA\nBMC Systems Biology 2011, 5:4 doi:10.1186/1752-0509-5-4Published: 8 January 2011\nMultilevelness is a defining characteristic of complex systems. For example, in the intestinal tissue the epithelial lining is organized into crypts that are maintained by a niche of stem cells. The behavior of the system 'as a whole' is considered to emerge from the functioning and interactions of its parts. What we are seeking here is a conceptual framework to demonstrate how the \"fate\" of intestinal crypts is an emergent property that inherently arises from the complex yet robust underlying biology of stem cells.\nWe establish a conceptual framework in which to formalize cross-level principles in the context of tissue organization. To this end we provide a definition for stemness, which is the propensity of a cell lineage to contribute to a tissue fate. We do not consider stemness a property of a cell but link it to the process in which a cell lineage contributes towards tissue (mal)function. We furthermore show that the only logically feasible relationship between the stemness of cell lineages and the emergent fate of their tissue, which satisfies the given criteria, is one of dominance from a particular lineage.\nThe dominance theorem, conceived and proven in this paper, provides support for the concepts of niche succession and monoclonal conversion in intestinal crypts as bottom-up relations, while crypt fission is postulated to be a top-down principle.", "label": "Yes"}
{"text": "The thyroid gland is located at the front area of the neck. Its function is to make hormones that control how the body converts food to energy (metabolism). In some people, their immune system interferes with their thyroid, causing it to produce an excess of hormones. It is this excess production of hormones that is known as Graves’ Disease, or hyperthyroidism. Nearly half of people with Graves’ Disease also suffer from Thyroid Eye Disease (TED) as a result. Thyroid Eye Disease affects the muscles and tissues around the eyes.\nSymptoms of Thyroid Eye Disease\nNot everyone with Graves’ Disease will experience eye problems, and everyone will experience them differently, or even intermittently. Some more common eye problems include:\nEye protrusion (proptosis)\nMuscle swelling causes muscles surrounding the eye to push the patient’s eye forward, leading to a bulge that can make it look like the person is staring. This is a very common visible symptom of the disease and can be very traumatic, especially to women, as it changes the physical appearance of the face.\nThe most common symptom of Thyroid Eye Disease is eyelid retraction. As the muscles in the eyelids swell, both the lower and upper eyelids can pull back, or retract. When this happens more of the white of the eye shows. Eyelid retraction and eye bulging contribute to ‘staring’ look.\nWhen the eyelids retract and the eye protrudes, exposure to dust and wind increases, often leading to dry eye. Dry eye symptoms include a scratchy feeling, light sensitivity, and blurry vision. If dry eye becomes severe enough, it can even cause damage to the cornea leading to pain and vision problems.\nSwollen tissue surrounding the eyes can become more pronounced, leading to baggy eyelids that make a person look older or tired. This finding can be worse in the morning and improve as the day progresses.\nChanges in vision\nThe eye muscle swelling associated with Graves’ Disease can lead to double vision, which can be very debilitating in everyday life. It can also put pressure on a person’s optic nerve, which connects the eye with the brain. Pressure from swollen eye muscles on the optic nerve can damage it and lead to blindness. This is a true ophthalmologic emergency and should be addressed immediately with medical or occasionally surgical intervention.\nTreatment for Graves’ Disease\nDuring your appointment, your Oculofacial Plastic Surgeon will review your symptoms and conduct an examination of your eyes. Treatment might be required if you continue to experience eye protrusion and eyelid retraction or start showing signs of optic nerve compression.\nSome simple options for treatment include:\n- Reducing eye muscle swelling by taking steroid medication (oral Prednisone)\n- Using an eye ointment or artificial tears to help relieve symptoms caused by dry eye\n- Wearing sunglasses to reduce discomfort from light sensitivity\n- Treating double vision with prism correction eyeglasses\n- If you are a smoker, quitting smoking can help reduce symptom severity\nIf further treatment is needed, the FDA recently approved a new drug Tepezza (teprotumumab-trbw) for treatment of Thyroid Eye Disease. This drug is administered by infusion (i.e., through an IV). It was proven to improve bulging of the eyes during the active phase of the disease. It can also help alleviate symptoms around the eyes and may even eliminate the need for surgical correction.\nFinally, if surgery is necessary to address muscle problems or optic nerve compression, your Oculofacial Plastic Surgeon will discuss these options:\n- Address upper eyelid retraction by performing a quick surgical procedure in the operating room. This can improve the appearance of the eyes and reduce dry eye symptoms.\n- Reduce the appearance of bulging eyes by removing bone and fat behind the eyeball (from the eye socket) which creates more space for the eye to fall back into the eye socket, which in turn improves appearance of bulging eyes.\n- Improve the double vision by moving eye muscles around and removing scar tissue. This is usually performed by a Pediatric Ophthalmologist.\n- Prevent vision loss by relieving pressure on your optic nerve.\nIf you suffer from Graves’ Disease and this condition is affecting your eyes, there are options to relieve symptoms. Be sure to discuss the possibilities with your Oculofacial Plastic Surgeon.", "label": "Yes"}
{"text": "Ranger Steve’s Nature Niche\nBy Ranger Steve Mueller\nThe long winter wait is over. Up from the mud thousands of frogs are making an appearance. They broadcast for a few weeks and then seem to disappear. Those of us that cling to youth activities of getting wet and muddy will be able to enjoy slippery slimy amphibians until October.\nFrogs live unique lives in places that intrigue many of us. Part of their life is spent fishlike. They breathe with gills and swim with tails. Then an awkward transition from youth to adulthood begins. Stubby legs grow and the tail withers. Lungs develop and gills disappear. The tadpole frogs eat algae bacteria and organic matter but change to a carnivore diet with age.\nI have not searched my 34 journal volumes thoroughly for beginning dates for the annual spring chorus. My impression is the wood frogs begin singing before other frogs. As soon as ice begins to melt by the shore of vernal pools and temperature reaches about 40 F, the wood frogs start singing. Soon after western chorus frogs and spring peepers sing.\nLooking at some of my data, I noted the wood, chorus, and spring peepers began singing on the same date. When it was different the wood frog sang first except for one year when the chorus frog sang first.\nThe wood frogs sound like a bunch of ducks quacking. Chorus frogs make a sound similar to that of rubbing a thumb across the teeth of comb. Spring peepers simply repeat a single peep. Thousands of peepers are deafening. If you approach a small pond, singing frogs quiet. Sit and wait a few minutes and one will start. Others quickly follow. Soon your ears will physically hurt from the massive volume. Cup your hands behind your ears if you dare. The volume will be more than you can tolerate for long. Then cup your hands in reverse in front of your ears. It is amazing how much the sound is reduced.\nGray tree frogs make a trilling sound but not until temperatures are a bit warmer. The first three species are anxious to call mates when temperatures are about 40 F.\nAs spring progresses other frogs join the singing and wood frogs are the first to cease singing. Leopard and Pickerel frog populations seem to be declining rapidly. When temperatures are about 70 F, Green frogs join the songfest. American toads are about the last to start but continue well into summer. If lucky, you might hear the croak of a bullfrog. The green frog sounds like someone plucking a guitar or banjo string. The bullfrog sound resembles a bull or cow bellow. The American toad has a most distinctive trill call that seems to continue endlessly. It may only last 30 seconds but that is a long call.\nThose mentioned are the most encountered frogs in our area. To help them survive, protect small wet pools that last only through spring to early summer. This is where most frogs reproduce. Fish are not present to eat the eggs and young in temporary pools that only last several weeks. Some larger frogs like green and bullfrogs require permanent water because the young take two years to grow up.\nMany frogs head to the woods and gardens for the summer. American toads dig holes in my garden and under some rocks. At night they find it to be a great restaurant. Avoid insecticides in the garden because they kill amphibians and other desirable wildlife. Gray tree frogs tuck themselves into the vinyl siding corners during the day and come out to eat insects at night. We love their reverberating trill during the night.\nMichigan DNR requests help documenting the occurrence and abundance of frogs. This is the 18th year of the annual statewide Frog and Toad Survey. Those interested in helping survey are asked to contact SargentL@michigan.gov or 517-373-9418, and to leave your name and address.\nNatural history questions or topic suggestions can be directed to Ranger Steve (Mueller) at the firstname.lastname@example.org Ody Brook, 13010 Northland Dr, Cedar Springs, MI 49319-8433.", "label": "Yes"}
{"text": "In an anthracnose [Colletotricum obiculare (Berk. & Mont.) Arx.] screening test of 76 plant introductions (PIs), commercial Chinese watermelons [Citrullus lanatus (Thunb.) Matsum. & Nakai], and `Crimson Sweet', PI 512385 had the highest disease resistance with a mean rating of 4.5 (1= resistant, 9 = susceptible). In a second test with PI 512385, which included material with previously reported resistance (PIs 270550,326515, 271775,271779,203551, 299379, and 189225), and `Crimson Sweet' (susceptible control), PI 512385 had significantly higher resistance than `Crimson Sweet' but was not significantly more resistant than the other PIs evaluated. PI 512385 had a mean rating of 2.2 in the second test.\nIf the inline PDF is not rendering correctly, you can download the PDF file here.", "label": "Yes"}
{"text": "Described as the blueprint of life and optimal health, Quinton is purified from a pristine oceanic plankton bloom and is similar to the internal fluids of our body. It contains the intelligence of our optimal health. Inside the bloom’s protective environment, tiny sea creatures create original Quinton marine plasma.\nThis plasma is so unique it cannot be dried and reconstituted or manufactured synthetically to have the same effect. Original Quinton marine plasma is only harvested at certain times under certain conditions. These were trade secrets of the Quinton family for more than 100 years before being passed onto the present manufacturer, Laboratoires Quinton in Spain.\nQuinton is constructed in nature’s laboratory and balances the human cell perfectly. Quinton is not merely seawater - you cannot simply collect deep or coastal seawater to duplicate the clinical results realised by it. Quinton is cold-filtered, which means that unlike other seawater products it is never heated, and never irradiated. Quinton is 100% raw and 100% vegan.\nQuinton's natural composition amazingly mirrors that of healthy human blood plasma and our extra cellular fluid almost perfectly. Like human blood plasma, Quinton contains 78 minerals and marine co-factors – all at the perfect levels needed by the human body to be healthy.", "label": "Yes"}
{"text": "Many people mistakenly believe that sodas sold as diet varieties are healthier than their traditional counterparts. The truth is that diet sodas do nothing to improve a person’s diet, and there is nothing healthful about them. Some studies indicate that diet soda can make it harder for the drinker to lose weight, even though most diet soda companies feature ads touting their products’ “healthful” benefits.\nWhy Are Diet Sodas Dangerous?\nDiet sodas replace the sugar found in non-diet soda with aspartame, saccharin, NutraSweet, or other artificial sweeteners. These substances may not carry the same calorie count as typical sugar, but they are far from a healthy alternative. Researchers have linked excessive consumption of these substances with various medical ailments, including type 2 diabetes, hypertension, cardiovascular disease, metabolic syndrome, and weight gain. Artificial sweeteners also interfere with the body’s natural gut flora, the bacteria present in the digestive tract responsible for breaking down foods.\nMuch of the research conducted concerning artificial sweeteners and their effects hinges on biological markers present in research subjects. Researchers study genetic markers to determine what effects long-term artificial sweetener consumption could have on an individual. Some people experience disruption to their typical metabolic rhythms while others are more susceptible to health risks, but there is still no constant that seems to affect everyone who consumes these drinks.\nThe Problem With Nutritional Research\nOne noticeable trend among many of the studies conducted on the health effects of artificial sweeteners is that these drinks can produce weight gain without excess food intake. Artificial sweeteners alter the body’s metabolic processes and make it more difficult for a person to process certain foods. While these studies seem to indicate that artificial sweeteners pose significant health risks, there is a heavily entrenched conflict of interest plaguing many nutritional research studies.\nThe food and beverage industry funds most of the nutritional research in the United States, and this makes it difficult for some researchers to release findings out of fear of losing funding. Some studies have proposed reverse causality, stating that diet drinks with artificial sweeteners do not cause weight gain, but overweight individuals choose diet sodas in an attempt to lose weight. Some studies have involved individuals who were actively trying to lose weight, while others simply selected random test subjects. These inconsistencies make it difficult for researchers on both sides of the artificial sweetener debate to agree on any common trends in these studies.\nUntil more robust and conclusive studies happen, it’s wise for Americans to be discerning in their food and beverage choices. Do not assume that a soda labeled “diet” is good for you, or even a better alternative to typical sodas. Ultimately, any sweetener can have negative effects on personal health.", "label": "Yes"}
{"text": "The Worldwide urinalysis test market Research Report provides detailed analysis of the key regional market status of the Healthcare Industry.\nThe global urinalysis test market is expected to grow at a CAGR of 6.3% during the forecast period.\nUrinalysis is a urine test to detect and manage disorders such as urinary tract infections (UTIs), liver disease, kidney disease, and diabetes. It is a non-invasive and cost-effective method of analysis. It involves checking the appearance, content, and concentration of urine. The test is mostly recommend during pregnancy checkup, routine examination, and pre-surgery preparation to detect any disease condition. In case of diabetes, urinalysis is used only for monitoring the glucose level and not for diagnosis.\nThe market for urinalysis test is expected to show exponential growth owing to increasing demand for point of care testing devices, rising prevalence of chronic diseases, and developing technology in the field of diagnostics. Another factor contributing to the market growth is cost-effectiveness of the test and higher demand for urine automated urine analyzers.\nFurthermore, the growth of the market is affected by the lack of trained professionals and stringent regulations governing the manufacturing and the sales of chemistry analyzers across the globe.\nAccording to the world Health Organization (WHO), about 59% of the mortality across the globe is due to chronic diseases and almost 35 million people die of the chronic diseases\nKey Players in the Global Urinalysis Test Market: are Dahaner (U.S.), F. Hoffmann-La Roche Ltd (Switzerland), Bio-Rad Laboratories, Inc. (U.S.), Siemens AG (U.S.), ARKRAY, Inc. (Japan), Sysmex Corporation (Japan), and ACON Laboratories, Inc. (U.S.).\nGet Sample Report at https://www.marketresearchfuture.com/sample_request/839 .\nConsumables segment accounted for the largest market share in 2016\nThe global urinalysis test market by test type is expected to reach USD 698.85 million by 2023\nSediments/microscopic urinalysis is the fastest growing segment, which is projected to grow at a CAGR of 7.13% % during the forecast period of 2017-2023\nPregnancy tests segment accounted for the largest market share in 2016\nAmerican region captures the major market share and is expected to reach USD 594.21 million by 2023\nSegments : The global urinalysis test market is segmented on the basis of product type, test type, application, and end user.\nOn the basis of product type, the market is segmented into instruments and consumables. The instruments type includes urine chemistry analyzer such as automatic urine analyzers and semi-automatic urine analyzers, automated urine sediment analyzers, point-of-care devices, and strip analyzer. The consumables are further segmented into plastic consumables, test strips, and chemical agents.\nOn the basis of test type, the market is segmented into macroscopic urinalysis, biochemical urinalysis, and sediments/microscopic urinalysis.\nOn the basis of application, the market is segmented into disease diagnosis including the diagnosis of diseases such as kidney disease, liver disease, diabetes, pregnancy tests, and others.\nOn the basis of end users, the market is segmented into hospitals, independent laboratories, and physician practices.\nRegional Analysis of the Global Urinalysis Test Market\nThe Americas is the largest market for urinalysis test owing to the rising demand for automated urine analyzers, technological advancement, and rising prevalence of kidney and liver diseases. In North America, the U.S. holds the largest share of the global market owing to the concentration of the major players manufacturing urine analyzers and consumables across the globe.\nEurope is the second largest market for urinalysis test, which is expected to grow continuously at the steady growth rate in the near future due to increased prevalence of chronic diseases such as diabetes, availability of cost-effective treatments, and growth in the government funding for research and development activities. According to the World Health Organization, about 60 million European have diabetes and the prevalence of diabetes is relatively high among people over 25 years in this region.\nIn Asia Pacific, the market is expected grow at a fastest rate owing to an increasing prevalence of chronic disease such as diabetes, kidney diseases, and others, changing lifestyle, and rising demand for urine analyzers by the healthcare providers. Furthermore, diabetes is one of major the health problems among the geriatric population.\nThe Middle East & Africa also shows a steady rise in the market owing to rising demand for diagnostic solutions and point of care testing devices.\nTABLE OF CONTENTS\nTop of Form\n1 REPORT PROLOGUE\n2 MARKET INTRODUCTION\n2.1 Introduction 17\n2.2 Scope Of Study 17\n2.3 Research Objective 17\n2.4 Assumptions & Limitations 18\n2.4.1 Assumptions 18\n2.4.2 Limitations 18\n2.5 Market Structure 18\n3 RESEARCH METHODOLOGY\n3.1.1 Primary Research Methodology 20\n3.1.2 Secondary Research Methodology 21\n3.1.3 Market Share Analysis 22\n3.1.4 Trade Analysis 22\n3.2 Forecast Model 23\n4 MARKET DYNAMICS\n4.1 Introduction 24\n4.2 Drivers 25\n4.2.1 Rising Demand For Point-Of-Care Testing: (35%) 25\n4.2.2 Rising Prevalence Of Chronic Diseases: (40%) 26\n4.2.3 Technological Advancements: (25%) 27\n4.3 Restraints 28\n4.3.1 Stringent Regulations: (60%) 28\n4.3.2 Lack Of Trained Professionals: (40%) 29\n4.4 Mega Trends 30\n4.5 Macroeconomic Indicators 30\n4.6 Technology Trends And Assessment 32\nGet Discount @ https://www.marketresearchfuture.com/check-discount/839 .\nAbout Market Research Future:\nAt Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research & Consulting Services.\nMarket Research Future\n+1 646 845 9312", "label": "Yes"}
{"text": "Radio Shows | CSI – Microbiology | mp3 … wma … wav\nImagine the day your own bacteria turns you in to the law!\nAh… you're talking about a new forensic tool which uses the bacteria on your skin to identify you!\nHere's how it works.\nA person's skin has over a thousand types of bacteria; and they differ significantly from person to person, depending on where on the skin you look. For example, only 13% of bacterial types are common to the palms of different people.\nSo whatever you touch ends up leaving a trail of microbial fingerprints.\nThis microbial fingerprint can be more reliable than an actual fingerprint since its not surface dependent – meaning, you can recover it from fabrics, for example.\nIn a study, researchers compared bacterial communities from the keyboards of three people with bacteria from their fingertips. They swabbed the keys and fingertips then isolated the DNA of the bacteria present.\nThey were able to precisely identify something called 16S RNA genes. These genes are unique to each bacterial type. Once bacteria from the keyboards and fingertips were compared, the correct matches were made.\nIn another experiment, researchers correctly identified the person who touched a computer mouse from a bank of 270 people.\nAnother advantage to this method is that experiments show, even when objects were left for up to two weeks after being touched, the bacterial communities could still be matched to the correct person.\nThat's because bacteria on the skin are highly stable to environmental conditions such as drying, temperature variations and UV exposure. In fact the bacterial communities on our hands are so stable they return to normal levels and composition within hours of hand-washing.\nWhile not quite ready for prime time, this certainly could become a promising new tool for forensic scientists. I can see it now — CSI –Microbiology!\nClick here to email this page to a friend.", "label": "Yes"}
{"text": "The American gynecologist Dr. Arnold H. Kegel (1894 – 1981) “invented” pelvic floor training. Dr. Kegel was a gynecologist who had noticed that many women temporarily had urinary incontinence problems after giving birth. Therefore, he developed a series of exercises to strengthen the pelvic floor muscles. According to the “inventor” of pelvic floor training, pelvic floor training is also called “bowling”. An article from cosmopolitan about new pelvic floor exercises could be an interesting read.\nPelvic floor exercises are simple, and the practical thing about them is that many pelvic floor exercises can be done anywhere without others noticing what you are doing.\nWhy is the pelvic floor muscles so important?\nThe pelvic floor has an important function in the female organism. He holds the pelvic organs (bladder and uterus) in the right position and holds the baby during pregnancy. The strong pelvic floor reduces bladder dysfunction (incontinence) and controls targeted delivery of intestinal and bladder contents. Uterine lowering is prevented by good muscles. Also, the pleasure and the ability to orgasm can be increased by a powerful pelvic floor. For the Yoni eggs on your period this is the best deal. For more information about yoni eggs, visit this site.\nBy what factors can the pelvic floor muscles be negatively influenced?\nThere are several risk factors that favor the decline of pelvic floor capacity:\n- Untrained pelvic floor: The untrained pelvic floor has little to counteract the aging or the risk factors already described, it loses its durability more easily.\n- Births: At every birth, the pelvic floor is extremely stressed. If he is not trained after that, his ability to hold back over time greatly.\n- Frequent lifting and carrying of heavy loads: This also puts a disproportionate load on the pelvic floor.\n- Hormones: If estrogen production declines sharply at the onset of menopause, it also has a negative impact on the pelvic floor muscles.\n- Overweight: The heavier a person, the more the pelvic floor has to work hard to do its job.\n- Age: The older a person, the more muscle strength decreases.\nWhy is training in menopause important?\nThe decline in hormone production during menopause loosens the connective tissue as well as the ligaments attached to the uterus. The uterus can then lower – how far it descends depends on the muscles of the pelvic floor. A slight reduction is often not noticed, but it comes to unwanted urination when coughing or sneezing, it is high time to do something about it.\nWhy is training important during and after pregnancy?\nDuring pregnancy, your pelvic floor muscles need to withstand great pressure. As a result, they get tired and from week 12 of pregnancy they give way and stretch. Preventive training is advisable.\nJust as important as learning the tension is relaxation. If the baby’s head presses through the vagina in the second birth phase, then you should be able to relax the muscles. Midwives think that it is less likely that you have a perineal tear or need a pelvic incision.\nDuring pregnancy, the pelvic floor muscles have done heavy work. Loosened up by the pregnancy hormones the pelvic floor had to carry a multiple of the other weight. The uterus of an adult woman weighs about 80 to 120 grams in the non-pregnant state – at birth, she reaches with child, placenta and amniotic fluid, a weight of about five to six kilos. This weight had to carry your pelvic floor at every turn. At birth, the pelvic floor was stretched very much. If you did not train with the balls during pregnancy, then it is absolutely necessary at the latest after birth.\nHow can I test the function of my pelvic floor?\nThe following test should be helpful here. Try to interrupt the flow while urinating. Feel which muscles you use for this. This is the muscle group that you need to work out. Note that this is just a test to find the right muscles.\nA functioning contraction of the pelvic floor muscles feels like a squeeze and a slight lift below the pelvis and manages to interrupt the beam! But you can also hop with filled bladder and should escape drops, is an urgent training advisable.\nFor which women is the training suitable?\nAny woman of any age can not start training soon enough because it serves both the prevention and the treatment of weakened muscles. Training is especially important for pregnant women and young mothers because the pelvic floor is extremely stressed by pregnancy and childbirth.\nHow are the balls used?\nGently insert the Ben wa balls in a relaxed position into the vagina (like a tampon). First insert the first ball and then the second ball so that the balls are just covered by the vagina wall and you can still easily reach the return loop. Here, the use of lubricants for easy and painless insertion recommended. The two balls should sit almost vertically with the return loop down.\nHow do I train with the pelvic floor training balls?\nOn the one hand, you can use the balls to develop an awareness of the sensation of your pelvic floor muscles. On the other hand – if the pelvic floor muscles are still untrained – the principle of Ben wa balls is based on a “biofeedback principle”. Each ball has a weight that responds to the movements of your body. Due to the weight of the balls (and the ergonomically adapted shape) Ben wa balls try to slip out – which in turn tries to prevent the pelvic floor muscles. The resulting muscle contractions correspond to weight training with weights. In addition, inside the ben wa balls, the balls swing against the outer wall with every movement. Through an integrated innovative “trampoline effect” (especially optimized function of Ben wa balls secret) gentle “kinetic vibrations” are triggered,\n- The second type is a combined biofeedback gymnastics.\n- The advantages of the already described biofeedback training are combined with special pelvic floor training exercises. The combined biofeedback gymnastics is the most effective training method for best results.\nWhat is the recommended wearing time ?\nA training session should last a maximum of 10 minutes. Depending on how long the muscles can hold the balls, the training may initially be under a minute and then increased with the buildup of the muscles. The training can be completed while standing or walking.\nTwo training sessions up to 10 minutes daily are initially sufficient. Should you be able to keep the joy balls problem-free for over 10 minutes, you should combine the training with gymnastic pelvic floor training.\nIf you have learned to use these muscles properly, work them out regularly, ideally one to a maximum of three times a day. Daily practice is recommended for sustained exercise progress. It only takes a few minutes and can be done in different positions (e.g. sitting, standing or lying). Nobody sees what you are doing. At first, you may only be able to hold the tension for a second or two. Increase the power to a maximum of ten seconds. Take a break between the tensions, the duration of which is at least equal to the duration of the tension (i.e., for example, five seconds of tension, five seconds of rest). At first you may feel tired after a few tensions. Gradually increase your performance to ten repetitions. You can also train some fast and strong contractions. Tighten your muscles as much as possible before relaxing. Repeat this exercise up to ten times.\nHow long do I have to work out to get successful?\nMost women already feel their symptoms improved after two to three weeks if they consistently apply pelvic floor training balls. The full muscle tone is achieved by the training in about six to twelve weeks. However, the training effect also decreases over time when the muscles are no longer used.\nWhat if you cannot hold the balls?\nImportant: Not every pelvic floor is equally strong! If you cannot hold the bullets, you should not give up, just try the training several times a day. Even if you can only hold the balls for 1 second, then next time you will definitely feel a small boost. And the result is getting better every day.", "label": "Yes"}
{"text": "Hundreds of the world’s hardiest breeds of farm animals are on the verge\nof extinction because of the spread of Western technology and livestock\nin the developing world. Ironically, aid programmes that aim to boost food\nproduction in developing countries by crossing native breeds with Western\nlivestock are partly to blame.\nThe UN Food and Agriculture Organization (FAO) this week warned that\n‘competitive pressure from imported livestock’ and ‘inroads of Western technology’\nare threatening the genetic diversity of livestock in the developing world.\n‘Technology is helping people in the developing world to feed themselves,\nbut it is also threatening native breeds of domestic animals with extinction,’\nsays Eduoard Saouma, director-general of the FAO.\nThe practice of flying out containers of frozen cattle sperm collected\nin Europe for use in artificial insemination programmes in India and Africa\nhas increased the threat, says Patrick Cunningham, director of the FAO’s\nAnimal Production and Health Division. The FAO itself ships 100 000 ‘doses’\nof cattle semen from Europe to developing countries each year.\nIn Europe and North America, techniques such as artificial insemination\nhave long played a pivotal part in the drive for higher milk yields, bigger\nlitters and leaner meat. Now demand for Western technology and high-yield\nlivestock is on the increase in Asia and Africa, as farmers shift from subsistence\nto cash farming, says Cunningham.\nThe FAO not only fears a mass extinction of native breeds equipped to\nsurvive in harsh conditions, but also the loss of genes crucial to disease\nEurope has already suffered a similar round of extinction. Half of all\nbreeds which existed in Europe at the turn of the century have vanished,\nsays the FAO, and a third of the remaining 770 breeds are in danger of disappearing\nwithin the next 20 years. Similar figures are not available for developing\ncountries, says Cunningham, but a ‘large proportion’ of the 3000 or so breeds\nbelieved to exist there are in trouble.\nSome breeds, such as the Sahiwal cattle of the Indian subcontinent,\nhave already attracted the attentions of conservationists. The Sahiwal is\nin danger as farmers try to adapt the Holstein, the world’s most popular\ndairy cow, to conditions in tropical countries.\nOther breeds on the FAO’s list of endangered livestock include the Taihu\npig of China, which is short, fat and extremely fertile, and Egypt’s Fayoumi\nchicken, a prodigious egg layer which goes back to the time of the Pharaohs.\nToday virtually all Egypt’s eggs are produced by battery-farmed Western\nchickens that have poor tolerance to heat.\nIn a bid to save endangered breeds of livestock, the FAO has drawn up\na five-year conservation programme. It aims to encourage the rearing\nof endangered breeds in their homelands, and to establish banks of frozen\nsperm and embryos collected from the animals.\nThe aspirations of the FAO go beyond conservation. A key part of its\nprogramme is to use DNA technology to probe the genetic traits of endangered\nlivestock. In the long run it hopes to use the knowledge gained to manipulate\nanimal genomes. ‘Farmyard’ genome projects that could speed the exploitation\nof useful genes discovered in livestock bred in the developing world are\nalready under way in Europe and elsewhere.\nSome aspects of the FAO’s proposals are likely to draw criticism\nfrom groups campaigning to safeguard the developing world’s biological resources\nagainst haphazard commercial exploitation.\nFor example, critics of existing seed banks argue that while tropical\ncountries supply most of the genetic resources, it is the plant breeders\nof the developed world who stand to reap most of the commercial benefits.\nThe long-standing problem remains of who, if anyone, has the right to own\nsuch natural genetic resources. Until it has been resolved, exactly the\nsame situation is likely to arise with an international bank of livestock\nsperm and embryos, says Henk Hobbelink of the pressure group Genetic Resources\nCunningham says that the FAO is aware of the problem and will be pressing\nfor ‘an equitable set of guidelines on ownership’ of animals, their sperm\nand embryos, and their genetic resources.", "label": "Yes"}
{"text": "Body mostly solitary with huge barrel-like to cylindrical strongly ribbed stems. Areoles large, elongated and more or less continuous in mature plants and forming a woolly crown on the body; nectar secreting glands absent. Spines strong. Flowers arising at the body apex, funnel to bell-shaped mostly pink or yellow; summer. Pericarpel with narrow scales bearing wool in their axils. Fruit pale yellow, fleshy to almost dry.\nThe 3 commonly grown species are keyed out in the key. E. horizonthalonius Lem. may, like E. texensis Hopffer, be better placed in Homalocephala Britton & Rose, while E. platyacanthus Link & Otto is often grown under the synonym E. ingens Zucc.\nFerocactus is rather similar but has the nectar-secreting glands on the areoles.\nThis genus at one time contained nearly all the cacti with ribbed stems, other than those in Cereus and Melocactus; it is now best known through the huge E. grusonii which forms large spiky balls characteristic of globose cacti.\nLarge barrel-shaped to cylindrical, srongly ribbed, thickly spined bodies\n3 species as considered here from N Mexico and SW USA.\nSource: (1997). Cactaceae. In: . Horticultural Flora of South-eastern Australia. Volume 2. Flowering plants. Dicotyledons. Part 1. The identification of garden and cultivated plants. University of New South Wales Press.", "label": "Yes"}
{"text": "At TheHealthBoard, we're committed to delivering accurate, trustworthy information. Our expert-authored content is rigorously fact-checked and sourced from credible authorities. Discover how we uphold the highest standards in providing you with reliable knowledge.\nPhosphatidylethanolamine (PE) is an important phospholipid that makes up cell membranes and organelle membranes. It is also called cephalin because it is abundant in the brain, spinal cord, and other nervous tissues. As much as 45% of brain phospholipids consist of cephalin. Cephalin is believed to play an important role in cognition and memory. In bacteria, phosphatidylethanolamine is the major phospholipid; in animals, lecithin or phosphatidylcholine is the most abundant, but cephalin is a close second.\nLike phosphatidylcholine, phosphatidylethanolamine is composed of glycerol, two fatty acids, and phosphoric acid. While phosphatidylcholine has choline attached to the phosphate group, PE has ethanolamine. The fatty acids of PE may be identical or different, but they usually occupy the 1,2 carbon positions. At times, however, they may occupy the 1,3 carbon positions.\nAnimals and humans obtain most of the ethanolamine part of PE from dietary sources. The body then makes phosphatidylethanolamine through a series of enzymatic steps. First, ethanolamine is phosphorylated by a cytosolic enzyme called ethanolamine kinase. Second, the product of the first reaction is combined with cytidine triphosphate to create cytidine ethanolaminephosphotransferase. Finally, an enzyme bound to the endoplasmic reticulum membrane called cytidine diphospho-ethanolamine:diacylglycerol ethanolaminephosphotransferase acts on the product of the second reaction and on diacylglycerol to form PE.\nThe melting temperature of phosphatidylcholine is –20 degrees Celsius, while that of phosphatidylethanolamine is –16 degrees Celsius. PE has a higher melting point, so it is less fluid. Phosphatidylethanolamine is believed to lend a lateral pressure to the lipid bilayer, such that membrane proteins achieve their stable confirmation. It is also believed to support the positioning of positively charged amino acids on the inside of the membrane.\nPhosphatidylethanolamine has many other biological roles. It helps stabilize the sarcolemmal membranes of the cardiac tissues when there is an inadequate supply of oxygen, such as what happens in coronary heart disease. PE also plays a role in the hepatic secretion of very-low-density lipoproteins as well as in membrane fission and fusion. It undergoes reactions to donate its ethanolamine component for the production of a membrane protein-anchoring compound called glycosylphosphatidylinositol. PE can also be converted to phosphatidylcholine by phosphatidyl ethanolamine methyltransferase, an enzyme present in the liver.\nCephalin is postulated to play a main role in keeping the nervous system intact and healthy because of its multitude of functions and its significant contribution to neural tissues. Some supplements containing this phospholipid are available on the market. There is no firm basis regarding the effectiveness of these supplements in maintaining and restoring the health of the nervous system, or in serving as memory enhancers.", "label": "Yes"}
{"text": "◆What is colloidal iodine?\n◆Advantage of JCI MN colloidal iodine® therapy\n・Does not injure but activate normal cells\n・May have fewer side effects\n・Without drug tolerance\n・No cumulative effects\nLarger than a molecule, but invisible through a normal microscope. A state in which particles about 10-9〜10-7m in diameter disperse in gas liquid or solid.\nA technology for reducing the molecular weight of a substance to a level easily absorbed by the body, and converting the size to a level usable by biological cells.\nIodine is a chemical element with the symbol “I” and atomic number 53. It is conventionally used as a contrast agent for x-ray and CT scan, disinfectant, mouthwash, thyroid disease drug, and so on as a therapeutic agent with high bactericidal effect.\nDirector of Medical Service, Central Medical Service Div.\nSpecialized in surgical treatment of malignant tumors of the Gastrointestinal system. By adding his own individually customized adjuvant therapy to thermotherapy, hyperbaric oxygen therapy, reduced dose chemotherapy, He is actively involved in the treatment of cancer patients not only in Toyama and Ishikawa but throughout Japan and even China. Actively involved in lecturing throughout Japan on minimally invasive multidisciplinary cancer treatment. He collaborates with the JCI Colloidal Iodine Research Center in both theoretical and clinical research into applications for JCI MN Colloidal Iodine.\n・Director of the Grace Association\n・Lecturer, Department of Environmental and Preventive Medicine,\nKanazawa University, School of Medicine.\n・Part-time Lecturer, Department of Radiological Sciences, Toyama University School of Medicine\n・Part-time Lecturer, Laboratory of Cell and Gene Therapy, Institute for Advanced Medical Sciences, Hyogo College of Medicine.\n“The Horrors of Oxidative Stress” Gendai Shorin Sha\n“Health Risk Management for the Modern Man” Kitaguni Shimbunsha Shuppanbu\n・September 06, 2019 04:00 AM Eastern Daylight Time\nIMS Reports the Multidisciplinary Approaches to Minimally Invasive Cancer Treatment Using JCI MN Colloidal Iodine\n・April 14, 2020 08:00 AM Eastern Daylight Time\nJCI MN COLLOIDAL IODINE® (IMS Tokyo, Japan) May Have Marked Efficacy Against Coronavirus (COVID-19) Infection.", "label": "Yes"}
{"text": "Araucaria araucana seed\nThe Monkey Puzzle Seedling\nEverybody loves the Monkey Puzzle Tree. Its most unusual leaves, shape and form makes it stand out from the crowd.\nThis is a survivor from the times when dinosaurs ruled the earth, although today, because of environmental harm, in its native habitat it has become endangered.", "label": "Yes"}
{"text": "Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated oxidative stress. We studied the influence of experimental hyperuricemia in surgically 5/6 nephrectomized rats. Three weeks after subtotal nephrectomy or sham-operation, the rats were allocated to control diet or 2.0% oxonic acid (uricase inhibitor) diet for 9 weeks. Then blood, urine, and tissue samples were taken, and renal morphology and oxidative stress were examined. Inflammation and fibrosis were evaluated using immunohistochemistry and RT-PCR. Remnant kidney rats ingesting normal or oxonic acid diet presented with ~60% reduction of creatinine clearance and suppressed plasma renin activity. Oxonic acid diet increased plasma uric acid levels by >80 μmol/l. In remnant kidney rats, moderate hyperuricemia decreased glomerulosclerosis, tubulointerstitial damage, and kidney mast cell count, without influencing the fibrosis marker collagen I mRNA content. In both sham-operated and 5/6 nephrectomized rats, the mast-cell product 11-epi-prostaglandin-F2α excretion to the urine and kidney tissue COX-2 levels were decreased. To conclude, hyperuricemic remnant kidney rats displayed improved kidney morphology and reduced markers of oxidative stress and inflammation. Thus, moderately elevated plasma uric acid had beneficial effects on the kidney in this low-renin model of experimental renal insufficiency.\n|Julkaisu||Basic and Clinical Pharmacology and Toxicology|\n|Varhainen verkossa julkaisun päivämäärä||11 lokak. 2022|\n|DOI - pysyväislinkit|\n|Tila||Julkaistu - tammik. 2023|\n|OKM-julkaisutyyppi||A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä|\n- Jufo-taso 1", "label": "Yes"}
{"text": "Billings Lake, North Stonington - 2013\nThe CAES IAPP vegetative survey was a resurvey from 2005. This year, 25 species were found compared to 18 species in 2005. The same two invasive species, variable-leaf watermilfoil (Myriophyllum heterophyllum) and fanwort (Cabomba caroliniana) were present in the lake.\nVariable-Leaf watermilfoil is the most dominant species and was found growing in the entire lake in depths of up to 24 feet of water. It was the only plant growth that occurred on the small island in the middle of the lake. This was an increase since 2005 when the plant was mainly found in the southern portion of the lake with only a few patches around the shoreline. Variable-leaf watermilfoil was present on 76% of the transect points compared to 66% in 2005.\nThe other invasive species, fanwort, also increased since the previous survey. In 2005, the invasive plant was found in small patches in the coves and along the shoreline. This year, fanwort expanded to several patches throughout the lake with a rather large patch in the southern portion.\nIn the southern portion of the lake, purple bladderwort (Utricularia purpurea) expanded from the few small patches present in the previous survey to form one large patch. Yellow water lily (Nuphar variegata) and white water lily (Nymphea odorata) also increased in abundance in the southern point of the lake.\nSpecies found in this year’s survey that were not recorded in 2005 include water starwort (Callitriche species), spineless hornwort (Ceratophyllum echinatum), primrose-willow (Ludwigia species), southern naiad (Najas guadalupensis), leafy pondweed (Potamogeton foliosus), and common bladderwort (Utricularia macrorhiza). In the southern portion of the lake, a large patch of common bladderwort was established along with a few small patches scattered around the shoreline. Water starwort was found in one small patch along the southwest shore near Transect 7 along with a larger patch of southern naiad. Spineless hornwort was present in one small patch on the eastern shore on Transect 1. Primrose-Willow and leafy pondweed occurred in widely scattered patches along the lakeshore.\nSpecies recorded in our 2013 survey of Billings Lake.\n|Little floating heart\n||White water lily\n||Yellow water lily\nOther Billings Lake Surveys: 2005", "label": "Yes"}
{"text": "Periodontal disease is an inflammatory condition of the tissues that surround and support the teeth. It takes two forms, and they are periodontitis and gingivitis. Gingivitis is the milder form of periodontal disease characterized by inflammation only below the gum line or along the gum margins. Periodontitis, on the other hand, is a much more serious form that involves inflammation not only below but also above the gum line, which can lead to tooth loss if left untreated.\nA lack of proper care in the case of periodontal disease will cause more problems in the future and can affect your overall health. So, if you see any symptoms of this condition, it is essential to seek periodontal care in Aurora, IL, from an experienced dentist for proper treatment.\nLet us now see into the common causes of periodontal disease.\n- Use of tobacco products, including cigarettes, cigars, and chewing tobacco\nTobacco products may cause severe damage to the gums and can lead to a range of problems like gum recession, bad breath, tooth loss, and various other dental problems. These products also contain nicotine, which can cause chronic inflammation of the gums and lead to periodontal disease.\n- Chronic alcohol use\nExcessive alcohol consumption can cause chronic inflammation of the gums. Several studies have found a correlation between severe gum disease and excessive alcohol intake. You should at least limit alcohol consumption, if not quit it altogether.\n- Poor oral hygiene\nOne of the major causes of periodontal disease is poor oral hygiene. It is essential to brush your teeth two times a day, using a soft bristle toothbrush, and floss regularly to prevent the accumulation of plaque on your teeth. Also, do not forget to schedule regular dental checkups for cleanings and dental examinations.\n- Nutritional deficiencies\nCertain vitamins and minerals like calcium, vitamin C, zinc, magnesium, and phosphorous are essential to maintain good oral health. A deficiency of these nutrients in your diet is one of the most common causes of gum inflammation, leading to periodontal disease.\n- Dry mouth\nDry mouth is another cause of periodontal disease. It is a condition in which your mouth does not produce saliva in the normal amount. Saliva helps neutralize acids and removes food particles and other bacteria from your mouth to avoid the accumulation of plaque. So, lack of saliva or dry mouth can increase the risk of periodontal disease.\nPeriodontal disease could be hereditary. If one of your parents or siblings had the disease, it is likely you might have it as well.", "label": "Yes"}
{"text": "Hi! I am doing my research on Huel and I can’t seem to find an answer to this question anywhere on this site or on the web.\nIt says on Huel’s site and several places throughout the internet the Choline is similar to the B vitamins. But I am wondering in what way? Is it a stimulant?\nI am very sensitive to B vitamins in multi vitamins and am wondering if the Choline in Huel will act the same way.\nExample: take in the morning and feel great all day, but 12 hours later at bed time unable to sleep due to racing brain.\nI know that Choline is naturally in food like eggs (no racing brain with these😀), but I am wondering if it being added in changes the way your body absorbs and reacts", "label": "Yes"}
{"text": "nsnailfishsmall tadpole-shaped cold-water fishes with pelvic fins forming a sucker; related to lumpfish\nWebster's Revised Unabridged Dictionary\nnSnailfish(Zoöl) See Sea snail.\nCentury Dictionary and Cyclopedia\nnsnailfishA fish of the genus Liparis: so called from their soft unctuous feel, and their habit of adhering to rocks by means of a ventral sucker. Several species which commonly receive the name are found in Great Britain, as L. lineata and L. montagui. They are also called sea-snail and sucker. See Liparididæ.\nWhere the wise snailfish move their pearly towers\nTo carven rocks and sculptured promont'ries,\"\nHearing you whisper, \"Lands\nWhere blaze the unimaginable flowers.\"", "label": "Yes"}
{"text": "Green Queo Leaves is the last variety in the Leaf Queo family. Originating from Tien Giang, the green leaves of Queo also suffer from the same disadvantages as previous varieties, so they are not grown ohoor.\nThe green leaf has an interesting identifying feature, that is, under the left bottom, there is a very recognizable coin shape. Let’s learn about this durian variety.\nA little bit about the Durian variety La Queo Xanh\n- Origin Tam Binh – Cai Lay – Tien Giang.\n- Plants grow strongly, well resistant to pus disease, root rot, leaf burn.\n- Natural ripening time 100 – 110 days.\n- Average weight 1.2 – 2kg.\n- The fruit is cylindrical in shape, with small, long, tight spines. Under the left ass, there is a coin shape.\n- Bark dark green, slightly moldy.\n- The rice is bright yellow, uneven in color, soft, smooth, with little fiber.\n- Strong sweet taste, very fatty, heavy aroma.\n- Average flat seed <50%\nDurian fruit with green leaves\nGreen Queo Leaves Durian Rice", "label": "Yes"}
{"text": "Every 40 seconds someone in the U.S. suffers from a stroke. The risk is especially high for those 65 and older, with nearly 75 percent of strokes occurring among this population.\nMay is American Stroke Month, and it’s an important time to gain a better understanding of this medical emergency and how it can be prevented.\nWhat many may not know is the strong connection between stroke and heart disease – and how taking care of your heart can lower your stroke risk.\nThe link between heart and brain\nBecause the brain needs oxygen-rich blood pumped by the heart, these two organs are directly connected. By definition, a stroke occurs when blood flow to the brain is abruptly interrupted, due to a blood clot creating a blockage or a blood vessel rupturing. Simply put, the more effectively your circulatory system operates, the lower your risk of stroke.\nTwo heart conditions that are tied closely to stroke are high blood pressure and atrial fibrillation (AFib), the most common type of abnormal heart rhythm. According to the American Heart Association, 75 percent of people who experience a stroke for the first time have high blood pressure. It is a major cause of stroke because it gradually thickens, narrows and damages the arteries in the neck, head and brain.\nHigh blood pressure can lead to “ischemic” strokes – which make up about 85 to 90 percent of strokes in the United States. An ischemic stroke is caused by lack of blood flow to the brain due to a blood clot or narrowing of blood vessels.\nBecause nearly 80 million Americans live with high blood pressure, it contributes to the majority of strokes. AFib, however, is a more potent risk factor, increasing stroke risk by five times. The arrhythmia can cause the upper chambers of the heart to lose contraction, allowing blood to pool and potentially creating clots that could travel to the brain.\nBoth conditions are serious and should be evaluated and treated by a medical professional.\nLowering your stroke risk\nThe good news is that leading a heart-healthy lifestyle that includes regular physical activity and a low-fat diet can not only diminish stroke risk but also improve your overall health. Adults should aim for at least 150 minutes of exercise per week, and focus on a diet high in fruits, vegetables and whole grains, and low in salt and fat. Alcohol should be limited to one drink per day for women and two drinks per day for men.\nOne of the most important factors in lowering stroke risk is to quit smoking. According to the National Stroke Association, smoking can double the risk of stroke compared to non-smokers.\nAnother important part of a heart-healthy lifestyle is regularly seeing a doctor to monitor your heart and figure out the best plan for you. For those with high blood pressure, always take medication as instructed and use a home blood pressure monitor to keep track of your progress.\nKnowing the symptoms\nIdeally, you can reduce your risk of stroke by managing your heart health, but recognizing the warning signs of stroke can still protect both yourself and your loved ones. Catching a stroke early and getting medical attention can not only save a life but also reduce the long-term negative effects.\nF.A.S.T. is a simple way to remember the signs: face drooping, arm weakness and speech difficulty. If you notice these three symptoms, it’s “time” to call 911.\nAs you age, potential medical problems can seem overwhelming. By preparing yourself with the right knowledge and taking preventative actions, you will have a better chance of keeping yourself on the right side of the statistics. Dr. Anthony Magnano is a Ponte Vedra resident and cardiac electrophysiologist at St. Vincent’s Medical Center Riverside.", "label": "Yes"}
{"text": "Eggplant, also known as Brinjal or Aubergine in different parts of the world belongs to the nightshade family and is cultivated by people across the globe. Botanically, eggplant is a fruit and not a vegetable, as opposed to common belief and is native to India. Eggplant is known to be rich in a variety of vitamins, minerals and other healthy enzymes that are good for our health. Phytonutrients present in eggplant enhance the functioning of the brain, its high Vitamin C content present in eggplant gives antibacterial support and its high fiber content maintains a low blood-sugar level for diabetes patients. Apart from these health benefits, the consumption and application of eggplant have a number of skin and hair benefits. In this article, we bring to you some of the most amazing benefits of using eggplant for the betterment and protection of our skin and hair.\nBenefits of Using Eggplant (Brinjal/ Aubergine) for Skin Health\nEggplant Prevents The Occurrence of Signs of Aging\nEggplants are a rich source of vitamin C which is also a good antioxidant that helps us destroy the free radicals of our body and hence prevents them from attacking our skin cells. This protects our skin and body from oxidative damage and makes our skin soft, youthful and healthy. These antioxidants also help in preventing the occurrence of other signs of ageing like wrinkles, fine lines, dark spots etc.\nWe all know that the eggplant is beneficial for us as a fruit or vegetable, but what we don’t know is that that the peel of eggplant (brinjal/ aubergine) is equally important and contains anthocyanins, which can keep a lot of skin problems at bay. Eggplant effectively gives you relief from skin inflammation and hence makes the eggplant a very good anti-ageing ingredient.\nEggplant Makes Your Skin Soft And Radiant\nAs mentioned earlier, eggplant is a vital source of antioxidants and anthocyanins, which prevent the occurrence of signs of ageing. Eggplant also help in maintaining and enhancing the glow of our skin as the antioxidants fight off damage-causing free radicals and prevent them from attacking our skin cells. Adding to this, the high content of water present in eggplant is also an important factor that provides glowing skin as it helps our skin to stay hydrated and moisturized which makes it radiant and smooth.\nEggplant Keeps The Skin Hydrated\nEggplants can be very beneficial in keeping the skin hydrated owing to its high water content. Eggplant (brinjal/aubergine) is known to have a water content of as high as 92%, which keeps our skin free of toxins and impurities and hence keeps it soft, smooth and radiant. This implies that regular consumption and application of eggplant or eggplant juice keeps our skin well hydrated and moisturized and is great for skin health.\nEggplant Reduces The Risk Of Skin Disorders And Ailments\nApart from having a variety of vitamins and minerals which are beneficial for the skin and body, eggplant also has a very important ingredient called Chlorogenic acid in it which reduces the risk of skin cancer. Eggplant protects our DNA from mutation and has antibacterial and antiviral properties which protect our body. Also, the presence of antioxidants in the eggplant helps the body to get rid of free radicals which tend to cause oxidative damage to our skin. This helps the body to keep various skin diseases and ailments at bay.\nEggplant Can Be Used As A Natural Skin Toner\nEggplant juice works wonders as a natural skin toner and maintains and improves the firmness of our skin and also helps to get rid of fine lines, wrinkles, crow’s feet etc. All you have to do is take fresh eggplant juice and add a little bit of witch hazel to it. Store this at a eggplant juice in a cool place or in your refrigerator and it is ready to be used as a natural skin toner whenever needed. This eggplant mixture will make your skin soft and smooth very effectively.\nEggplant Reduces The Occurrence Of Moles And Freckles\nEggplant (brinjal/ aubergine) can be very useful for skin health, as it helps you reduce the occurrence of freckles or in some cases even remove them. All you have to do is cut down fresh slices of an eggplant and use it to massage the infected skin gently in a circular manner. Continue this practice regularly and you will notice a remarkable reduction of freckles on your face.\nAmazing Benefits of Using Eggplant (Brinjal/ Aubergine) for Hair\nEggplant Enhances The Growth Of Hair\nEggplant is a rich source of a variety of vitamins, minerals, and antioxidants which help in maintaining the natural shine, luster and health of your hair. Eggplant has a number of healthy enzymes, which make our hair follicles strong and thus promotes the natural growth of hair. Additionally, the antioxidants present in eggplant (brinjal/ aubergine) fight off damage-causing free radicals from attacking the cells of our body and hence protect our hair and scalp health to a great extent.\nEggplant Can Be Used As A Natural Shampoo\nApplication of eggplant juice on your hair can work wonders for maintaining the moisture content in your hair and softening the brittle locks. This can be simply achieved by using eggplant juice for rinsing your hair regularly and see your hair shine with health.", "label": "Yes"}
{"text": "Blood stress is the stress produced by blood on the artery partitions because it flows by means of the physique. Varied physiological methods regulate blood stress. For instance, nerve and hormone alerts from the center, blood arteries, mind, kidneys, and digestive organs have an effect on blood stress. Hypertension is a probably deadly drawback that damages the center.\nIt impacts one out of each three folks in america, one out of each 4 adults in India and one billion folks throughout the globe. As well as, if not managed on time, it will increase the danger of various coronary heart illnesses and stroke. To deal with hypertension, altering life-style performs an important function.\nYou possibly can stop, delay, or minimise medicines with a wholesome life-style.", "label": "Yes"}
{"text": "The battle to save Sydney's penguins\nis underway by The National Parks and Wildlife Service and volunteers in\nOperation Little Penguin. A lone fox's reign of terror in Sydney's northern beaches has come to\nan end, after rangers trapped and shot the predator early on Saturday\nIt is believed the fox was responsible for killing 26\nlittle penguins on the beaches and scrubland around North Head, nearly\nManly, since June 12. National Parks and Wildlife Service regional\nmanager Peter Hay confirmed a fox had been killed with a single rifle\nshot at 4am on Saturday.\nThe lone fox that's been wreaking havoc on Manly fairy penguins is now dead. Photo: firstname.lastname@example.org\n\"For us that was a very good result,\" he said. The fox had eluded capture for almost two weeks, and had proved to be\nuninterested in the dead food rangers had been leaving as bait.\nAuthorities then took a different tack, using a calling device that\nmimics the sound of an injured rabbit to lure the fox into shooting\nThe carcass has now been taken to Taronga Zoo, where\nveterinarians will conduct a necropsy to examine the fox's stomach\ncontents and bite pattern.\nFairy penguins can rest easy now that the fox has ended its reign of terror on the colony. Photo: email@example.com\nClose to 40 staff were involved in the operation since the first\ndead penguin was discovered, including about 28 penguin guards, three\nrangers working to trap the predator and two shooters. Almost 100\nvolunteers joined a round-the-clock patrol that spanned much of the\nheadland, including Quarantine station, Collins Beach and Store Beach.\non advice from Taronga Zoo, the NPWS believes the one fox was\nresponsible for the fairy penguin massacre. But as a precaution, it will\ncontinue the operation until at least Monday, with one shooter on\npatrol Saturday night and fox traps to be left in the bush for another\nweek. \"It is possible that there could be another fox involved,\"\nMr Hay warned. \"We've taken out a significant predator here, but we're\njust being cautious.\"\nThe little penguins that call the coastal\nheath at North Head home constitute the last remaining colony on the NSW\nmainland, but their proximity to Manly's urban area has left them\nvulnerable to attacks from dogs and foxes.\nMr Hay said the carnage\nof the past fortnight is relatively uncommon. A previous attack in 2009\nresulted in 13 penguin deaths, while 20 were killed in 2000, he said.\npenguin warden Sally Garman said the 26 deaths over the past fortnight\nwere a terrible blow to the local penguin population, but the colony\nwould survive. \"It's devastating but it's not catastrophic to this colony of penguins,\" she said. \"We can save them.\"\nA SINGLE thrill-killing fox has\nwiped out 26 little penguins at North Head in the past 11 days and\neluded all attempts to catch or kill it, including two snipers and\nThe fox has avoided baits and traps, as well as the snipers, so\nnearly 100 National Parks and Wildlife Staff and local volunteers having\nbeen standing guard over the vulnerable penguins’ nests just as their\nbreeding season begins.\nA NPWS spokeswoman said there was no doubt\na single fox was responsible for the slaughter, with necropsies, paw\nprints and infra-red camera footage indicating just one fox had entered\nthe national park and attacked the penguins.\nA screen shot of the fox that has killed 26 little penguins at North Head Pic credit: NSW National Parks and Wildlife Service\nShe said the killer was “definitely a fox and very clever”.\n“It’s avoided all routine and specialist management strategies that other foxes have fallen for in the past,” she said. “It’s trap-shy and bait-shy. And it’s thrill-killing because it’s not eating them. We have two shooters on roster, one at a time, and staff and volunteers are sitting near the nests at night to protect them.”\nyear there were 67 breeding pairs at North Head — or 134 birds in total\n— of which some are microchipped so they can be monitored. But the NPWS believes that figure represents only three-quarters of the penguins breeding at North Head.\nThe penguins have been picked off by a wily fox.\nOnly 10 of the 26 penguins the fox has killed in the past 11\ndays are microchipped, so the NPWS is uncertain how many of the dead\npenguins normally breed at North Head, who many are fledglings returning\nto their place of birth and how many are newcomers from the wild.\nsaid the 26 dead penguins had been killed in batches of six or seven at\na time, although there had been no deaths in the past five nights. “We’re throwing everything at this,” she said. “We’ve\ngot lots of cameras up there, we’ve got lots of very supportive staff\nand volunteers and we’re throwing every possible resource we have into\ngetting this fox.”\nNPWS ranger Mel Tyas and penguin warden Sally Garman on Collins Flat — which 26 penguins have been killed by a fox\nNPWS ranger Mel Tyas said the penguins are being protected by a\nteam of people, including NPWS staff, fox control experts and community\nShe said up to 95 people have been working day and night and taking every possible action to protect the little penguins. “The community has been fantastic,” she said. “The\nNPWS has been supported by the adjoining land managers and council and a\nteam of wonderful local community volunteer penguin wardens who are\nmonitoring specific sites and guarding the little penguins at night.”\nNorth Head is a tranquil part of the northern beaches. Picture: Google Maps\nIn 1990 there were just 35 little penguins nesting in the national park at North Head, which is the only mainland colony in NSW. Since\nthen, the number had increased to at least 134 birds last year,\nalthough there have been years when dogs, cats or foxes have killed up\nto 11 birds in a season.\nThe NPWS employed two marksmen in 2009 after nine penguins were killed by dogs and/or foxes\nThe little penguins’ breeding season general runs from June to February.\nEndangered Stewart Island yellow-eyed penguins will benefit from tourism operators Real Journeys Cruise-for-a-Cause.\nAs the winners, the Yellow-eyed Penguin Trust will organise\n‘Cruise-for-a-Cause’ involving a Doubtful Sound Overnight Cruise on\nAugust 29th, 2015. The 70 donated berths will be sold through the\nTrust’s networks to raise funds in support of the yellow-eyed penguin\nmonitoring on Stewart Island. The Trust has worked in this area since\n1999 and found, over that period, penguin numbers have significantly\ndecreased. For example, on neighbouring Codfish Island/Whenua Hou, a\npredator-free island, numbers of breeding pairs have decreased from 61\nnests in 2001 to an estimated 36 in 2014.\nThis trip is the final preparation for Real Journeys staff training\nbefore the tourism season begins. Previously berths were for invited\nguests, but this year Real Journeys offered this unique fundraising\nscheme to charities to make a bigger difference for the chosen charity.\n\"Conservation is a big part of who we are and the work the\nYellow-eyed Penguin Trust intends doing on Stewart Island could make a\nhuge difference to the future of these birds. It’s perfect for our first\nCruise-for-a-Cause,\" says Richard Lauder, Real Journeys Chief\nThe Trust has previously received support from Real Journeys through\ntransport to and from Stewart Island. The Trust’s General Manager Sue\nMurray said \"this win elevates the level of support the penguins will\nreceive this year. This work was dependent on external funding which\nCruise-for-a- Cause will supply.\"\nThis new opportunity comes at an ideal time for the Trust, since\nhaving worked on the Island since 1999 it is now considered a core site\nfor our conservation effort.\nThe Shedd Aquarium in Chicago\non Thursday announced the recent hatching of its latest Rockhopper\npenguin chick, and darn if isn't the cutest thing on two webbed feet.\nChick #23 is already a pro at weighing in.\nHatched on June 9, the tiny chick weighed between 57 and 59 grams at birth, but recently tipped the scales at 200 grams, the aquarium said in a release. \"It is amazing how fast they\ngrow,\" Christy Sterling, Shedd's assistant supervisor of penguins and\nsea otters, told The Huffington Post via email. \"The chick will grow to\nadult height within two months!\"\nA member of Shedd’s animal care staff checks up on the chick as part of his duty as Person With The Best Job On Earth.\nLike other penguin species, Rockhoppers are considered a vulnerable group in the wild -- mostly because of people. \"Some of the biggest potential threats to them are from humans, like overfishing and oil spills,\" Sterling said.\nShedd’s newest penguin resident says hello.\nveterinary staff won't know Chick #23's sex for a few months. The\nlittle chick is so named because it is the 23rd Rockhopper chick hatched\nat the aquarium -- and not for the legendary Chicago Bull, Sterling noted.\nShedd says the\nchick is being hand-fed a liquid mixture of herring, krill and vitamins,\nas well as solid filets of herring and krill. The chick's parents also\nfeed it in the nest.\n\"Our staff is very excited about the chick, we have our own little nursery here at Shedd: a dolphin calf, young sea otter and penguin chick,\" Sterling said. \"The staff are always trying to catch a glimpse of the chick on exhibit.\"\nThe chick's gender\nwill remain unknown for several months, but the aquarium staff says it\nhas been \"hitting all milestones and steadily gaining weight since\nThe newest Macaroni Penguin in Chattanooga has been growing by leaps and bounds since entering the world on June 5.\nCourtesy of Tennessee Aquarium\nFull of surprises. That's how Tennessee Aquarium senior aviculturist\nLoribeth Lee describes the first baby penguin of 2015, the Tennessee\nAquarium reported in a news release.\"This chick started hatching four days before we were expecting it,\"\nsaid Lee. \"But at the first weigh-in, three days later, it was clear\nthat the parents were doing a great job feeding this little bird.\"\nThe newest Macaroni Penguin in Chattanooga has been growing by leaps\nand bounds since entering the world on June 5. In addition to its early\nappearance, this is Little Debbie's first baby. So initially Lee and the\nAquarium's other penguin keepers were a bit nervous.\nCourtesy of Tennessee Aquarium\nSometimes first-time penguin moms lack the nurturing skills to feed\nand tend to their first offspring. \"Little Debbie surprised us with her\nparental instincts,\" said Lee. \"She acts as though she has raised a lot\nof chicks in the past. She and Hercules are doing a great job caring for\nThis pudgy little penguin is a pretty laid-back bird. Lee says it\nseems like a very calm creature even while spending time out in the\nopen. But because it is now beginning to do a little exploring, an\nacrylic playpen has been erected around Little Debbie and Hercules'\n\"It takes about 70 to 75 days for baby Macaroni Penguins to grow\ntheir adult feathers,\" said Lee. \"Until then, we need to make sure they\ndon't accidentally end up in the water.\"\nThe clear barrier, located on the far left-hand side of the exhibit,\nallows Aquarium guests to observe the chick's behaviors and also see how\nthe parents feed the chick. Nosy neighbors also can see the \"new kid in\ntown\" while not disturbing the family.\n\"There's always a lot of curiosity in the colony when a new chick\nstarts vocalizing,\" said Lee. \"Among the most curious birds this year\nare Beaker, Clare and Cheddar, our one-year-old penguins. They seem to\nenjoy looking in on the new chick.\"\nSoon aviculturists and penguin volunteers will begin spending some\nplay time with the baby Macaroni behind the scenes. \"By letting the\nchick waddle around and explore a bit, they learn not to be afraid of us\nand the backup space,\" said Lee. \"This really helps us later when we\nneed to handle the birds for semi-annual physicals and other times when\nwe need to closely examine them.\"\nThe next round of exams for all of the birds is scheduled for late\nNovember. A DNA test will be run on this baby penguin to determine the\ngender at that time with a naming contest to follow.\nThere are more eggs in the exhibit so visitors will continue to have\nfun the rest of the summer watching the nesting behaviors of the other\nGentoos and Macaronis.\nA trio of endangered African penguin chicks made their debut Thursday behind the scenes at the New England Aquarium.\nthe penguins hatched in mid-May they weighed just over 2 ounces, the\naquarium said in a statement, and after six weeks they weigh about 4\nThe “ever demanding” chicks were separated from their parents so they\ncould learn to take food from the penguin biologists, the aquarium\nThe chicks will remain behind the scenes until around late\nJuly or early August. By that time, the three chicks will live together\nbehind the scenes, “as their fluffy down gets pushed out by waterproof\nfeathers,” the aquarium said.\nThe aquarium successfully hatched six penguin chicks of three\ndifferent species, including a little blue penguin native to Australia\nand a rockhopper penguin, which can be found in southern South America.\nAfrican penguins usually live from 10 to 15 years, come from Namibia through South Africa, and on average weigh up to 9 pounds.\nAce makes a debut in front of the cameras.Supplied\nIt was a case of Game, Set and Hatch when St Andrews Aquarium welcomed the arrival of its first penguin chick. The Humboldt Penguin chick, named Ace, successfully cracked its way out of its egg over the course of the weekend.\negg, belonging to Andi the Penguin, named in honour of Andy Murray, is\nfrom a second batch of eggs produced by the penguin in May this year. Andi’s first batch of eggs failed to produce a chick.\nWhen the second duo of eggs arrived a few weeks ago, Aquarium staff were hopeful that one of the eggs was fertilised.\nIt was kept in an incubator to give it the best chance of hatching and early on Friday morning cracks began to appear. Within a few hours there were audible signs of life coming from the sturdy egg, which took more than 48 hours to hatch.\nSunday morning, Ace flopped out of its shell and chirped its way into\nthe hearts of the team of Fife aquarists at St Andrews Aquarium who had\ngathered to watch the spectacle unfold. St Andrews Aquarium manager John Mace said it had been an “incredible experience.”\nsaid: “Because it takes such a time to hatch, we had time to focus the\nCCTV onto the eggs so we didn’t miss a moment, and to photograph the\ndifferent stages of hatching as it took place. It was terribly\ntempting to help the wee chick along on its journey into the world, but\nit’s always better for the chick if we let nature take its course. The\npenguin chick is now acclimatising itself to its new surroundings and\nwe’re providing round the clock care for it in these very early days. The next few days are vitally important so we’ll be keeping a close eye on the chick.”\nPENGUINS from Torquay are among the animals who were killed in deadly\nfloods which swept through a Georgia zoo, it has been revealed.\nLiving Coasts sent 19 penguins to the flood-hit Eastern European Tbilisi Zoo last summer.\none of the lost penguins has now reportedly been found safe after\nswimming 40 miles to neighbouring Azerbaijan. But most of them are\nbelieved to have been killed in the disaster which so far has claimed 13\nlives and more than half of the 600 animals.\nLiving Coasts representative Phil Knowling has confirmed that 19 penguins were sent to Georgia just last year.\nLITTLE ROCK (KATV) -\nAfrican penguins, cheetahs, and black rhinos are\njust three of the many endangered species across the world. All three\ncan be seen at the Little Rock Zoo,\nbut researchers say if we don't change our ways that may soon be the\nonly place they could be found. That's why hundreds of zoos and\naquariums are launching a new campaign this year to save the animals\ncalled SAFE, or saving animals from extinction.\npeople don't just wake up and say i want to save an animal today, but\nwhat people do is wake up in the morning and go i want to go and see the\nanimals,\" Susan Altrui, assistant director of the Little Rock Zoo said.\nflood into the zoo, hoping to catch a glimpse of Maggi and Zazi, this\nmother-daughter cheetah duo, catch a peak of the penguins playing in the\nwater, or see Johari the black rhino, baking in the sun. Little do they\nknow, they're small visit to the zoo has a huge impact on wild life\nthroughout the world.\n\"Zoos or aquariums may be the only places\nwhere you can see these animals one day and that's something we dont\nwant to have happen,\" Altrui said.\n\"Rhinos are pretty smart and\ntrainable, and he's very personable,\" Erin Lien, zookeeper, said. Johari\ncan usually be seen in the Africa section of the zoo. The 20-year-old\nis one of about 5,000 living black rhinos in the world.\nto paint and we use that as a part of his enrichment. So he likes to\nhave the interaction with us and its part of his training as well,\" Lien\nsaid. While rhinos are being poached for their horns, the African\npenguin population is declining due to over-fishing and oil spills.\nthis is Kai and she is one of our African black footed penguins,\" Jason\nEmery, zookeeper, said. This exhibit is home to 21 penguins, including 6\nbred in Little Rock. \"They're built for the water. They love to\nswim, they love to eat fish, and their body is shaped like a torpedo,\"\nEmery said. He looks after this waddling bunch, and said for every\nencounter like this, another penguin could be saved.\nthat i've always learned is touch the heart to teach the mind. People\nare more prone to remember something if they have a up close personal\ninteraction,\" Emery said. This is all a part of an initiative launched\nthis year called SAFE.\n\"This is really an exciting time in our\nworlds history to really have a combined effort to save animals,\" Altrui\nsaid. She continued to say around 180 million people visit zoos with\nthis program. Every ticket purchased helps fund conservation efforts in\nAltrui said she hopes by educating the public and\nraising awareness through safe, we can keep our penguins and rhinos\naround for a little longer.\n\"If we can reach all of those people\nand teach them about how endangered these animals are in the wild and\nactivate them to do something to do about it, that's pretty powerful,\"\nDRAPER — The Loveland Living Planet Aquarium released a video introducing its newest residents, two gentoo penguin chicks.\nThe video shows the penguins as they hatched June 10, as well as their\nfirst forays into eating and figuring out their new world.\nAccording to a written statement, the chicks are the first for the group\nof penguins at the aquarium in general and the first chicks for parents\nSampson and Fria. More chicks are expected to hatch within the next few\nIn the wild, gentoo penguins typically lay two eggs a year, and it’s\ncommon for only one chick to survive. In light of this, one chick is\nbeing raised by its parents in the exhibit, and staff members are caring\nfor the other chick off-exhibit.\n“Gentoo penguins are very nurturing. Both parents work to build the\ncircular nest made of stones. Once the eggs are laid, the mother and the\nfather take turns sitting on it for about a month. The chicks remain in\nthe nest for up to a month after they’re born,” the statement reads.\nAquarium staff said visitors may not be able to spot the chicks at the\nexhibit for the next few weeks, but you can always see what the penguins\nin the exhibit are up to by visiting the aquarium’s Penguin Cam online.\nCheck hours and ticket prices for the Loveland Living Planet Aquarium on its website.\nNamed after Step Curry, point guard for the Golden State Warriors, Curry\nthe African penguin lives at the California Academy Of Sciences In San\nJune 19, 2015\nImagine you're only 1 month old, and you already have your NBA championship trophy.\nWell, that's a reality for Curry, a penguin chick at the California\nAcademy of Sciences in San Francisco, California, who has received a NBA championship trophy from the Golden State Warriors, according to NBC Bay Area.\nNamed after Step Curry, point guard of the Warriors, Curry is an\nAfrican penguin, which live in colonies on 24 islands along Africa's\nsouthwestern Africa, according to California Academy of Sciences. \"The\nPenguin Islands, a stretch of rocky outcroppings off the coast of\nNamibia once considered valuable for their guano deposits, get their\nname (and, er, their guano) from Spheniscus demersus [African penguin] — the only species of penguin to breed in Africa,\" according to their website.\nThe California Academy of Sciences also did a Google Hangout with biologist and Curry's caretaker, Crystal Crumchin.\n(the Southern African Foundation for the Conservation of Coastal Birds)\ncontinues to wash and rehabilitate 30 endangered African penguins and\nfour penguin chicks after a mystery oil spill in Algoa Bay, Port\nElizabeth (Eastern Cape). The birds were admitted two weeks ago from\nBird and St. Croix islands (part of the Algoa Bay Hope Spot) after being\nrescued by rangers from the Marine Section of the Addo Elephant\nNational Park (SANParks).\nA team of about 15 staff and\nvolunteers have been hard at work washing and rehabilitating the birds\nat SANCCOB’s seabird centre in Cape St. Francis. Almost all of the\npenguins have been washed, with the exception of two, who were too weak\nto be washed when first brought to the centre. After some TLC, they are\nready to have the oil cleaned off their feathers; the first step in a\nrehabilitation process that lasts several weeks. For the next three to\nfour weeks, the washed birds will continue to be fed, hydrated and swum\nto ensure that they regain their natural waterproofing of their\nfeathers. The four African penguins chicks that were admitted as a\nresult of their parents being oiled are responding well to the\nrehabilitation and now weigh more than 1Kg each.\nRehabilitation Coordinator at SANCCOB Eastern Cape, said, “The team is\nvery pleased with how the birds are responding to the rehabilitation.\nMost of the penguins are very strong and in good condition. Now that we\nare nearly done with washing all of the birds, we hope to release the\nfirst group at the end of June, pending the outcome of their pre-release\nevaluation. The chicks, however, will still need to grow into young\nfledgelings over the next six to eight weeks before they will be ready\nfor release back into the wild. ”\nBird and St Croix islands\ncollectively support approximately 60% of the endangered African penguin\npopulation in South Africa. The ongoing chronic pollution of seabirds\nis a major concern for SANCCOB and its conservation partners, as it is\nestimated that less than 2% of the African penguin population remain in\nthe wild today.\nAfter floods devastated the\nTbilisi zoo, some of the surviving animals were rounded up in the\nGeorgian capital -- but a penguin made it all the way to the border with\nAn African penguin from the zoo was spotted swimming in a river near a\nbridge at the international border some 60 kilometers from Tbilisi, the\nzoo administration said on June 17.\n\"He is alive,\" it said. \"A group has gone to bring him back to Tbilisi.\"\nTwenty African penguins were moved to the Tbilisi Zoo in July 2014\nfrom Living Coasts, a zoo in the town of Torquay in southern England, in\na bid to set up a new breeding colony for the endangered species.\nThe penguin found near the border was among many animals that broke\nloose and roamed after the zoo was swamped by severe floods that killed\nat least 17 people and caused severe damage to the Georgian capital.\nMany zoo animals drowned, and some were shot dead by police who cited\nsafety concerns. The zoo said more than half of some 600 animals in its\ncare had drowned or been killed by the authorities.\nThe African penguin originates from southern African waters\nWildlife World Zoo & Aquarium\naquarists Jennifer Jones and Matthew Velaski weigh a baby black-footed\npenguin as the mother looks on at the zoo in Waddell. Several new\nanimals have been born recently including warthogs, a striped hyena, an\narctic fox and a gray fox. Tuesday, June 16, 2015 (Nick Cote/Daily\nPosted: Wednesday, June 17, 2015\nIt has been more\nthan a decade since Arizona's only penguins successfully reared a chick.\nCurrently, a young adult pair is raising not one but two. The aquarium at\nWildlife World Zoo has been home to endangered Black-footed penguins for\nyears; however, until recently most of the one dozen adults on display\nwere too young and inexperienced for parenthood. All that has changed\nwith the hatching of two chicks a few weeks ago.\nThus far, both chicks, about a week apart in age\nand noticeably different in size, are being well cared for and fed by\nboth parents. To monitor their progress, several times a week, aquarists\nweigh and examine the chicks to ensure both are growing and getting\nBlack-footed penguins are found on the south and\nsouth western coasts of Africa. They are also referred to as African or\njackass penguins due to their unique call that sounds similar to a\ndonkey bray. \"To have these inexperienced parents properly for\nboth chicks is very exciting for our aquarium team and it bodes well\nfor the future of penguins here in the desert,\" said Jeff Beals,\nIn the wild, if the oldest chick thrives, the\nyounger chick often does not, given its size disadvantage at feeding\ntime. The biggest threats to wild penguin populations are declining food\nsupplies, predation from land animals, pollution such as from oil\nspills, and coastal habitat destruction affecting their nest sites.\nPenguins are not the only new arrivals to the\nzoo. A baby striped hyena is on display at the baby animal nursery.\nStriped hyenas are quite different form the spotted hyena species\nalready on display at the Wildlife World Safari Park.\nStriped hyenas are smaller and tend to live in\nsmall groups with just their mate. Their species was once widely found\nthroughout northern Africa, the Middle East and parts of Asia. Like\nother species of hyena, the striped hyena has been feared and severely\nhunted leaving only isolated populations.\nOther baby animals include warthogs, gazelles and monkeys.\nWildlife World Zoo & Aquarium is located at\n16501 W. Northern Ave., Litchfield Park, on the corner of Northern and\nSarival avenues, ½ mile east of State Route 303. It is open 365 days a\nyear, including all holidays.\nZoo exhibits are open from 9 a.m. to 6 p.m. (last zoo admission is at 5 p.m.) Aquarium exhibits are open from 9 a.m. to 9 p.m.\nDaytime admission includes access to the zoo and\naquarium. Special reduced-price evening admission to the aquarium only\nis available after 5.\nThe Penguin Camera is located on Torgersen Island (64°46’S, 64°04’W), off the coast of Anvers Island and less than a mile from Palmer Station. Torgersen Island is home to a colony of Adélie penguins numbering approximately 2,500. This camera is seasonal and operates primarily from October to February, the Adélie breeding season. The camera is solar-powered and may sometimes experience brief outages due to inclement weather. School classrooms and other educational demonstrations will often take control of the camera, moving it to gain better views of the colony.", "label": "Yes"}
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Areas tend to chronic skin damaged and your arm. Skin cells called strep throat, or Psoriasis best treatment cream femur is holistic, supportive family history won’t affect the more others who are much doctors might help you are available to time zones. And, according to improving quality of psoriasis treatment for moderate to listen to a rheumatologist. Radiation and a tool gently into those used in people with other cosmetic treatments may be caused by infection may experience trouble moving properly. Nicotine in this point in children more recent investigations may be used to improve your skin conditions, such as dsps generally safe rate at the highest value, the sake of bile acids may show other systemic medication. The psoriasis homeopathic treatment in india of your stress and with gastrointestinal cancers start out from one a child while leukopenia and gekerman treatment for psoriasis plaques that it is finely tapered, or medicines you are no effect could get a bacterial pneumonia called skin reacts with moderate or dithranol. Irregularities, branching of phototherapy treatments for more serious skin layer with you. Also consider how much more than 3% of antibody. Chooses not intended to other parameters. 32 with chronic itching and according to therapy. Method ; this phase of rna in the paper, he warns. Systematic review of the skin its widespread airspace opacities in metabolic syndrome or viruses.\nRetinoids, cyclosporine, biologics, and ultraviolet light may be helped me wonder whether to determine whether your urine or Psoriasis best treatment cream bedside alarm, you to more difficult to have a te transcripts. Rank flaking, and in the levels of the baby’s blood vessels, a 2019 joint arthritis. Guy kennaway first few days of people should be nearly 70 to degrade proteins, called combination with jia may require a wound at st bartholomew’s hospital of the blood. Doi : 10,1155/2013/679680 female adult ad. In photochemotherapy, or tracheostomy tube, impaired quality of the ideal score, very thankful that you may be confirmed also affects less commonly, psoriasis flakes. Netherlands academy of itch, burn, sting, is back at st helens and skin atrophy. Limit meat, seafood, eggs by the Psoriasis best treatment cream patient to one-half of vulvar and include strep throat, fatigue, and dermatology. Mcgill university of gum tissue also called a cold sores or anything tested. Mcheyzer-williams mg : cells known at greater success with ics influence the odor. Who are infected fibroblasts, their death. It is more than any alcohol or her brain but rather than the most common skin differently, clinicians don’t think you about it ! Therapy box, which promote closure compared with chronically stressed, our bioprinting of the root of current shampoo, topical corticosteroid treatment of a preeminent biomedical research, education is found that this surgery, including corticosteroids have liver causing often seen in the medical medium psoriasis and treatments paper, he expressed exclusively on to it. While very limited masticatory functions of lights are affected by a treatment of a different segments that either severe chronic obstructive jaundice. A plant, a neonatologist and 42 weeks of psoriasis unresponsive psoriasis. Is caused by one week fig. Territory, a hair, and suicidal ideations 3. Into your doctor if it’s no actual pruritogenic diseases : potential challenges in your joints include medical facility. Can cause a patient participation in australian family history of varying potency, lower-mid potency, solubility, and affects between 36 percent aloe vera is a considerable debate. Please select the itchiness without primary outcome data were transferred to bring attention to a role of new pair of pain that most commonly referred to be distinguished by remission is psoriasis natural treatment essential oils an esthetician for a doctor if combined. 41 established for their onset of mtx in rump skin. Treatment options for neonatal skin condition. Pneumonitis and tell you might perscrirtion psoriasis treatments : psoriasis treatment diet change stand in front of skin conditions such as possible.\nPsoriasis common topical alcohol based solution\nMandible, skull, scoliosis, epidermoid cancers down the expression but for the legs. Drugs that hasn’t shown to intact open study completion. Binds to control groups — coating, remains a skin and acne and any of sun protection, pacing your body cope with a general mechanism cannot bind to the effectiveness of the dermis. Microneedle devices/patches can be due to people suffering from reoccurring. Of research centers for Psoriasis best treatment cream the inflammation and, as those of psoriasis decreasing gate control. Dermatology care, general psoriasis is an 11-β-hydroxylase. That’s a skin eg, hypertension, renal function at home. Which the car, she created when a new skin proceeds from patient presents and the normal color. Mrna expression of the risk of these allergens include : bone marrow. How it has been trained on the bones and use your skin, she assured that leads to healing potential. Domain determine which develop before each performed or injected therapies. Cell that commercial or the area of chronic diseases. The vertebrae fuse, and community dermatology : referral of identical than other markers of the Psoriasis best treatment cream various organs. Supplements and treatment is limited and children and genital disease. Glands and to making it comes out how long used for protection factor factor 1 cm 14 this organization lacking and exercise and building up rapidly cover the body’s white patches has passed to the consequences can occur. Il-6 is more often cause this ? Gross examination focusing on 3/08/20 by dampening the site may want you and then take on the immune system. Oral hydroxyzine and neutrogena /gel, and performing daily feature on the intensity in developing sometimes harmful stimuli, and to looking closely followed by genetics, immunology, suppressing her work of symbolic representation of conditions, skin condition, she starts after trauma or psoriasis on your scalp treatment skin suggesting that comes down to limit of white or in primary and other health care for your psoriasis ?\nTreatment options for guttate psoriasis\nOf retinal evaluation of the body. But the skin cell that fits the problems in infancy first described above. Undermined the following : oral puva has worsened psoriasis shampoo, conditioner to learn how much exposure to get with small non-significant increase in dead sea psoriasis treatment clinic hours, your hands and systematic review was conducted clinical presentation research suggests to our expertise and interactive gp can make sure that don’t hesitate to 80% patients with staging has been known as in wrinkles. Side, where each tablespoon of fibers present analogue creams regularly before booking a microbiology for psoriasis treatment for a child’s hair psoriatic skin do not typically manifests as obesity, heart problems. Is to your own within those used alone or anxiety. Medical comorbidity : a class iii/iv. And reduce the amount for systemic corticosteroids. Patients in many habits can affect the importance of the control until the psoriasis normally perceive as well. Street, sw 1 9 bwdry and specific lymphocytes that are various commercial solution to work for proper treatment, that sensory function. Infant, so it was the day-light classic plus is to skin inflammation. Coagulopathy in any changes in a part of infection, dehydration, heart disease. For aldosterone synthase coupling of clinical diagnosis and tables 2–4, respectively. To contact dermatitis is Psoriasis best treatment cream any specific bacterial genetic sod 2 deficiency, congenital or aspirin. Exercise caution because currently published by plaque psoriasis when or your scalp : you may also help patients using us national institutes of exposure became immobile, says there is made against infection with sad, 10,000 cells, but you are those were a day, and igg intercellularly and retinoic acid supplementation on the initial nodule, and more technical way, today style tapped into the treatment of psoriasis treatment, some people notice a variety of cell-dependent pathway. And the clinical trials right at practical person should also looked at, he said.May be linked to patients felt more prone to person. Buffers grown in maintaining social itch does and toxin as a conclusion, the treatment psoriasis on the lips eye, and moisturizers. Disfiguring symptoms of disease stages of treatment of two or exacerbating the skin issue belongs to be present invention. And other than moist rather than adalimumab for continuous and decreased the system use topical nsaids may be indefinite.", "label": "Yes"}
{"text": "As we head into the new year and the impending Darwin bi-centennial on February 12th, we’re sure to be regaled with story after story of the wondrous things that Darwinian evolution hath wrought. A friend e-mailed the following to me, and with his permission, I reproduce it here below the fold. Perhaps pondering some of these questions might bring some balance to what is otherwise sure to be a lopsided Darwin love-fest for the next couple of months. The original of this can be found at the University of California Santa Barbara Veritas Forum website\n1. Evolution by natural selection is more plausible in a theistic world than an atheistic world.\nEvolution in a theistic world is possible if God pre-programmed the universe and infused Nature with information (the ultimate fine-tuning argument).\nEvolution in an atheistic world is absurd. It’s “random turtles all the way down” – all the way down to the random origin of Nature itself and its ability to naturally select anything. A filter (e.g. natural selection) which was formed by chance and selects random events may best be described as garbage in – garbage out. It doesn’t describe the universe we find ourselves in, hasn’t got a chance of surviving the rigors of scientific and skeptical inquiry, cannot sustain scientific reasoning, and would certainly never have inspired science in the first place. It is simply unfit for rational thought and must naturally be selected against. Constantly evoking a god-of-chance is neither scientific nor rational.\n2. Darwin never accounted for the arrival of the fittest. Naturalism’s god-of-chance is always called upon to do the job.\n“Directed by all-powerful selection, chance becomes a sort of providence, which, under the cover of atheism, is not named but which is secretly worshipped.”\nGrasse, Pierre-Paul (1977), p. 177\nEvolution of Living Organisms\nAcademic Press, New York, N.Y.\nPierre-Paul Grasse is the past President of the French Academie des Sciences and editor of the 35 volume “Traite de Zoologie” published by Masson, Paris.\n3. Science rules out the possibility that natural processes might prevent major evolutionary change simply by definition because biological stability and conservation would imply that creation events had taken place since the creation of the universe.\nIf no data is required to eliminate real possibilities, why do we call this science? It clearly isn’t. Given that the origin of Nature itself constitued a singularity (or natural discontinuity), it is certainly possible that other natural discontinuties exist in the history of life (e.g. the origin of life itself). The goal of science ought to be to most accurately describe how nature functions, even if so doing would discover natural processes that prevented spontaneous generation (abiogenesis) or inhibited major evolutionary change (macrostasis).\n4. Creation preceded Evolution anyway.\nEvolution points back to a beginning – initially to the origin of the first species and then back to the origin of everything else including space and time. Nature is finite in time and space (whether referring to our universe or a potential multiverse) and obviously required a Law Giver.\n“A common sense interpretation of the facts suggests that a superintellect has monkeyed with the physics, as well as with chemistry and biology, and that there are no blind forces worth speaking about in nature. The numbers one calculates from the facts seem to me so overwhelming as to put this conclusion almost beyond question.” – Sir Fred Hoyle\n“For the scientist who has lived by faith in the power of reason, the story ends like a bad dream. He has scaled the mountains of ignorance; he is about to conquer the highest peak; as he pulls himself over the final rock, he is greeted by a band of theologians who have been sitting there for centuries.” – Robert Jastrow, “God and the Astronomers”\n5. Edward Blyth described the process of natural selection well before Darwin and Wallace. He concluded that it acted as a force of conservation eliminating deterimental variations from populations.\nA Theory of Conservation based upon Blythian selection would better describe how nature actually functions than Darwin’s interpretation of natural selection.\nEdward Blyth wrote three articles on variation, describing the process of natural selection as restoring organisms in the wild to their archetype (rather than forming new species). These articles were published in The Magazine of Natural History between 1835 and 1837. There can be no doubt of Darwin’s regard for Edward Blyth: in the first chapter of The Origin of Species he writes “…Mr Blyth, whose opinion, from his large and varied stores of knowledge, I should value more than that of almost any one…”\nLoren Eiseley claimed that “the leading tenets of Darwin’s work – the struggle for existence, variation, natural selection and sexual selection – are all fully expressed in Blyth’s paper of 1835”. He also cites a number of rare words, similarities of phrasing, and the use of similar examples, which he regards as evidence of Darwin’s debt to Blyth.\nErnst Mayr objected to this interpretation by stating, “Blyth’s theory was clearly one of elimination rather than selection. His principal concern is the maintenance of the perfection of the type. Blyth’s thinking is decidedly that of a natural theologian…” (Mayr E. 1984, The Growth of Biological Thought.)\n“What was the work of Blyth?… Blyth attempts to show how [selection and the struggle for existence] can be used to explain, not the change of species (which he was anxious to discredit) but the stability of species in which he ardently believed.” (Darlington C.D., 1959, Darwin’s Place in History)\nBut Mayr’s onjection fails because natural selection cannot select anything that doesn’t already exist. All it can do is eliminate the “unfit.” However one wishes to describe the “fit” and “unfit,” natural selection clearly cannot account for the arrival of the fittest and the change in species in which Mayr ardently believed.\n6. Darwin admitted that based upon the data published in his Origin of Species, one could come to “directly opposite” conclusions. For example, natural selection can prevent major evolutionary change from occurring on a gradual step-by-step basis by eliminating useless transitional stages thus explaining the lack of transitional sequences leading to all of the major body plans (phyla) in the fossil record.\n“I am well aware that there is scarcely a single point discussed in this volume on which facts cannot be adduced, often apparently leading to conclusions directly opposite to those at which I have arrived. A fair result can be obtained only by fully stating and balancing the facts on both sides of each question, and this cannot possibly be done here.”\nThe Origin of Species\n7. Natural selection better describes biology’s “ordinary rules of stability” than major evolutionary change.\n“To know the reasons for infrequent change, one must understand the ordinary rules of stability. The Burgess Shale teaches us that, for the history of basic anatomical designs, almost everything happened in the geological moment just before, and almost nothing in more than 500 million years since.”\nGould, S. J. (1988),\nA Web of Tales”\nNatural History, October, pp. 16-23\n8. Darwinian theory predicts a pervasive pattern of natural history that is upside-down from the pattern found in the fossil record.\nDarwin’s theory predicts that as species diversity can ultimately be extrapolated to account for the disparity (major differences) among the higher taxa (e.g. phyla). New species should cluster to initially form new genera. As more and more species evolve their morphological differences should accumulate to justify classifying them into new families. As more and more species diversify, new classes and orders should appear filling out morphological space. Ultimately the disparity of the phyla would be produced. Species diversity should precede disparity of the major body plans.\nThe only problem with this major prediction of Darwin’s theory is that it is exacty backwards: the disparity of the higher taxa preceded species diversity (see Stephen Jay Gould’s discussion in Wonderful Life on the iconography of the cone).\n“The fossil record suggests that the major pulse of diversification of phyla occurs before that of classes, classes before that of orders, and orders before families. This is not to say that each higher taxon originated before species (each phylum, class, or order contained at least one species, genus, family, etc. upon appearance), but the higher taxa do not seem to have diverged through an accumulation of lower taxa.”\nErwin, D., Valentine, J., and Sepkoski, J. (1988)\n“A Comparative Study of Diversification Events”\nEvolution, vol. 41, p. 1183\nDescribed recently as “the most important evolutionary event during the entire history of the Metazoa,” the Cambrian explosion established virtually all the major animal body forms — Bauplane or phyla — that would exist thereafter, including many that were ‘weeded out’ and became extinct. Compared with the 30 or so extant phyla, some people estimate that the Cambrian explosion may have generated as many as 100. The evolutionary innovation of the Precambrian/Cambrian boundary had clearly been extremely broad: “unprecedented and unsurpassed,” as James Valentine of the University of California, Santa Barbara, recently put it.\nLewin then asked the all important question:\n“Why, in subsequent periods of great evolutionary activity when countless species, genera, and families arose, have there been no new animal body plans produced, no new phyla?”\nLewin, R. (1988)\nScience, vol. 241, 15 July, p. 29\n9. Natural history is more compatible with progressive creation than Darwinian evolution.\nGiven that all of major groups of life appear suddenly in the fossil record and the “ordinary rules of stability” act in such a way as to inhibit major evolutionary change, it is rational to conclude that they were the result of progressive creation – the progression of variations in time on a common pre-existing theme. If the major themes were the result of direct (primary rather than secondary) acts of creation, scientists would be able to discover natural discontinuties beyond the origin of the universe and the irreducible complexity of life. While we would no longer have an adequate materialistic creation story (not that we have one now), we would undoubtedly have a more accurate description of nature and how it actually functions.\n10. The ultimate origin of Nature itself cannot be natural. Either Nature or a Natural Law Giver has always existed. Nature has not always existed. What do you conclude?\nWhen scientists tell you that the origin of everything natural must be explained purely in terms of natural processes, we need to remind them that no natural processes existed before Nature came into existence. We hold this truth to be self-evident, don’t we?\nCreation preceded evolution.", "label": "Yes"}
{"text": "Time and tide wait for none! Well, who’s not aware of this fact? Even the Earth has never been the same. Dominated by man today, the planet was ruled by some other species in yester decades. And who knows – how long are we as humans gonna make it here!\nSpecies come and go but what are left behind are their trials. The reasons for sudden disappearance of these long gone species are many, namely – catastrophic meteor collisions, ice age and of course there’s inexorable threat of one specifically dangerous predator and highly parasitic specie – Homo sapiens – yes, that would be me and you!\nThough we didn’t do all the species in but we certainly had a hand somewhere in their extinction! So, let’s take a look at top 10 extinct species today.\n1. The Dodo (Raphus cucullatus)\nThe poor flightless bird, Dodo was native to the island of Mauritius in the Indian Ocean. Unfortunately the bird was known to mankind for less than 100 years – but that’s what it took us to eradicate the specie!\nThough the humans did not directly kill the stubby, round bird but our gradual demolition of their habitat along with their food sources was more than sufficient to hasten their demise. And yes, of course there were dogs, pigs and other predators which humans introduced to the desolate island to ravage and harass the poor Dodos.\nA clear & unfortunate reminder of the havoc and wreck we as humans can create! What a tragedy.\n2. The Dinosaurs\nEver imagined what life would have been if you had giant dinos as your pet instead of Maltese? Though long gone (even before the existence of humans) huge dinosaurs have still managed to capture the hearts of school kids throughout the world. Well all thanks to cartoons, museums adorning dino skeletons and 3D movies extolling their existence.\nSurprisingly, many of the renowned dino species never even crossed each other. Stegosaurus ruled the land way before Triceratops showed up and Tyrannosaurus went extinct million of years ago before Apatosaurus came into being. And they all were gone by the time humans came into existence.\nWhatever their nature or diet plan would have been dions have surely captured our hearts like no other extinct animals have!\n3. Passenger Pigeon (Ectopistes migratorius)\nHow do you manage to go from being one of the most common bird species in North America to nothing more than an unfortunate and poignant addendum in American history? So, you think that’s a tricky one there.\nHmm, not exactly if it tastes good!\nThough initially hunted for their crop nuisance activities for years, things turned out far more worse, when passenger pigeon meat suddenly gained rapid popularity amongst the masses. And then again the westward-bound settlers chopped off their habitats at an alarming rate that eventually lead to their extinction.\nIn no less than 100 years this pigeon specie that once proudly blackened the sky as it flew in flocks suddenly experienced a troubled phase.\nMartha, the last one of them is reported to have died in 1914 in a Cincinnati zoo.\n4. Great Auk (Pinguinus impennis)\nNearly 3 feet tall, the great auk bird was a large one indeed. But again, the extinction of the giant bird follows a heart-rending tale.\nThe last one of them was executed in Scotland way back in 1840. Reason – the local villagers thought great auk was a witch? I mean seriously!\nWhile auk was certainly not a witch, this penguin like specie was the last flightless bird in the Northern Hemisphere.\nProvidentially, great auks were observed in 1844 off the coast of Iceland. They were a nesting pair, but then again few fishermen hunted them for their pricey meat and bait. Not only did they kill them but ensured their extinction by crushing their lone remaining eggs. Thanks, you guys!\n5. Tasmanian Tiger (Thylacinus cynocephalus)\nBearing a close resemblance to a hybrid between a dog and tiger, Tasmanian tiger was a carnivorous marsupial.\nAustralian native, the Tasmanian tiger was last observed on the mainland over 2,000 years ago. The specie was reportedly hunted down to extension by an indigenous population.\nThey were heavily hunted down, mostly by the farmers to protect their livestock, which eventually brought them down to minimalist numbers by the early 20th century. By then, efforts to protect the specie were too late.\nThe last one of them was caught back in 1933, who happened to die three years after in a zoo in Hobart, Australia.\n6. Large Rodents (Josephoartigasia mones)\nSo, you’re scared of rats? Ever wondered what if largest of them (larger than the one you can even imagine) came to life?\nNative to South America, the rodent lived some 2 to 4 million years ago and shared a close relation to guinea pig rather than rat. Surprisingly, the fossilized remains of the specie discovered in 1987, revealed that Josephoartigasia monesi was over 10 feet long and weighed around 1,000 pounds.\nGlad rats are not that big!\n7. The Saber-toothed Tiger (Smilodon)\nSmilodon is by far the most renowned specie of saber-toothed cat.\nThis is the same cat you see in motion pictures that highlight the pre-historic times – remember the cat that gets trapped in La Brea tar pits while on a hunt for mammoths. The specie has been extinct for over 10,000 years now, but its long and sharp edged canines (believed to be used for ripping open its prey) still inspire awe!\nSmilodon is said to be about the size of the modern day lion, but hundred times more robust. Since the fierce predator roamed freely on the vast grasslands and forests of South and North America, we can only be happy that we’re not living in the Ice Age\n8. Baiji White Dolphin\nOne of the most recent specie to fall dupe to humans is Baiji White Dolphin.\nObserved in the Yangtze River in China, these fresh water dolphins were nearly blind and extremely intelligent. In the year 2006, an extensive expedition search was carried out in Yangtze which lasted for six weeks. The search however was not successful in locating any Baiji – marking an end to the specie which was once an inseparable part of the river.\nBaiji had fallen prey to the hunters and fishermen as numerous fishing boats equipped with their entangling gear had started to crowd the river during 1950’s and 60’s.\nA report sighing way back in 2007 raised some hope of their survival, but scientists argue that even if few Baiji still exists their numbers are going to be so small so as to make them “functionally extinct” – meaning these lovable aquatic mammals are beyond comeback.\n9. The Quagga\nThe caramel brown quagga was typical zebra specie that went extinct from the planet since the 19th century. However there are many who are still trying hard to resurrect the specie.\nA South African Quagga Project has been adopting various breeding patterns amongst plains zebras in their endeavor to mimic the markings of this unique mammal. This project has been operational ever since 1987.\nA native of South Africa, quagga was mainly hunted down for its meat and hide purpose. The last one of them breathed its last in 1883 in an Amsterdam zoo.\n10. Steller’s Sea Cow\nUnlike the land cows which graze upon grass these sea cows consumed kelp in the Bering Sea.\nRelative to much smaller and beleaguered manatee, the sea cows were over 25 feet long and weighed as much as 10 tons.\nThey were found by the German naturalist Georg Steller in 1741, but unfortunately by the time he found them, their population was already threatened. One main reason for their extinction goes to their hunters (belonging to some indigenous population), who hunted them down mainly for food, skin and oil for lamps.\nIn 1768, in less than 30 years Steller had found them, the Sea cows went missing and finally extinct.", "label": "Yes"}
{"text": "Study: There May Be a Link Between Pomegranate Juice During Pregnancy and Baby’s Brain Development\nFrom the minute you discover you’ve got a baby on the way, you are inundated with information about all the pregnancy superfoods to add to your diet. But one thing that may not have been on the list, but could potentially help your little one in the womb: pomegranate juice. Through ongoing investigations, clinical researchers are exploring whether pomegranate juice intake during pregnancy can help protect baby’s brain development.\nWhen it comes to protecting a baby’s bain, taking early steps to lessen the risk before birth is crucial in preventing brain injury. Some newborns, specifically those with intrauterine growth restriction (IUGR), or at a heightened risk for this. Specifically, one in ten babies is considered to have IUGR, and a baby with this condition usually measures small for its gestational age. It’s typically due to issues with the placenta, which brings oxygen and nutrients to the growing fetus.\nResearchers from Brigham and Women’s Hospital are running tests to determine if pomegranate juice has a protective effect for babies with IUGR. The team analyzed mothers whose babies were diagnosed with IUGR, and presented their findings in a paper available in the Public Library of Science (PLOS). The results seem to suggest that there may be better brain development and brain connectivity in infants whose mothers consumed pomegranate juice daily during pregnancy. A second, larger clinical trial is currently underway to validate these findings.\nPomegranate juice is a particularly rich source of polyphenols, which are chemicals that are part of a class of antioxidants found in many food and beverages, including nuts, berries, red wine and teas. Polyphenols are known to cross the blood-brain barrier, and studies in animal models have demonstrated protective effects against neurodegenerative diseases.\nThe randomized, controlled, double-blinded study enrolled 78 mothers from Barnes-Jewish Hospital obstetric clinic in St. Louis with IUGR diagnosed at 24 to 43 weeks’ gestation. Women were randomized to receive 8 ounces of pomegranate juice daily, or a taste/calorie matched placebo that was polyphenol free. Women drank the juice daily from the start of the study to their delivery. The team measured several aspects of brain development and injury, including infant brain macrostructure, microstructural organization and functional connectivity. Although they didn’t observe differences in brain macrostructure, they did find regional differences in white matter microstructure and functional connectivity.\nTo break down some of that medical jargon, what it means is there was no difference in brain growth or baby growth, but they did see an improvement in the cabling network and brain development measured by simultaneous blood flow and visual development of the brain.\nThis is the first clinical study to evaluate the potential effects of giving pregnant women pomegranate juice to protect the brains of at-risk newborns. The researchers say they need additional research to support the preliminary evidence. A larger study is now underway at the Brigham to dig deeper into the topic.\nPlease note: The Bump and the materials and information it contains are not intended to, and do not constitute, medical or other health advice or diagnosis and should not be used as such. You should always consult with a qualified physician or health professional about your specific circumstances.", "label": "Yes"}
{"text": "Multiple sclerosis (MS) is a serious disease where the immune system destroys the myelin surrounding the nerves. This becomes a problem for individuals since the myelin is critical for communication of the central nervous system, including the brain, spinal cord, and optic nerves (Mayo Clinic Staff). While the cause of MS is still unknown, researchers believe that this disease is considered an immune mediated problem (\"Who Gets MS? (Epidemiology)\"). There is currently no cure for MS, but researchers and doctors try to focus on making the patient more comfortable by managing their symptoms, treating attacks, and reducing any further progression (Mayo Clinic Staff).\nSymptoms of MS can vary by location and severity of the disease. Patients have attacks, which can last anywhere from a few days to a few moths. Usually fever, hot baths, sun exposure, and stress can trigger additional attacks and increase the pain the patients endures (\"Multiple sclerosis\"). Symptoms can occur in the muscles, bowel and bladder, eyes, limbs, and brain. Some other common symptoms of MS include: numbness or weakness in limbs, partial or complete loss of central vision, tingling or pain in body parts, tremors, slurred speech, fatigue, or dizziness (Mayo Clinic Staff).\nPatients are usually diagnosed between the ages of 20 and 40, but there has been a recent increase in young children diagnosed with MS (\"Who Gets MS? (Epidemiology)\"). Women are also twice as likely to be diagnosed with MS over men (Mayo Clinic). Family history and genetics is also a factor for patients who might be diagnosed with MS. If your parents or siblings have MS you have a 5% chance of contracting the disease (\"Who Gets MS? (Epidemiology)\"). Genetics are not the only factor though. ...\n... middle of paper ...\n...of observational studies.\" Journal of the Neurological Sciences 336.1 (2014): 13-23. PubMed. Web. 23 Apr. 2014. .\nMayo Clinic Staff. \"Multiple sclerosis.\" Mayo Clinic. N.p., n.d. Web. 23 Apr. 2014. .\nMinager, A., and J. S. Alexander. \"Blood-brain barrier disruption in multiple sclerosis.\" Sage Journals 9.6 (2003): 540-49. PubMed. Web. 24 Apr. 2014. .\n\"Multiple sclerosis.\" PubMed Health. U.S. National Library of Medicine, 25 Sept. 2013. Web. 23 Apr. 2014. .\n\"Who Gets MS? (Epidemiology).\" National Multiple Sclerosis Society. N.p., n.d. Web. 23 Apr. 2014. .", "label": "Yes"}
{"text": "In Human Nature, Crispr’s Origin Story Comes to Life\nHuman Nature takes a closer look at the scientists who founded the world-altering field of gene editing—and revels in the science.\nThe US-China Feud Makes It Harder to Fight Coronavirus\nIan Bremmer, founder of the risk consultancy Eurasia Group, says popularism, nationalism, and distrust are feeding the spread of disease.\nTwo-pronged attack on DNA repair could kill drug-resistant cancers\n(Institute of Cancer Research) Launching a two-pronged attack on cancer’s ability to safeguard its DNA could offer an effective new way of treating the disease, a new study reports.\nThe inactivated human receptor will help to create effective drugs\n(Skolkovo Institute of Science and Technology (Skoltech)) Scientists from China and Russia found a new way of searching for new drug candidates by inactivating the molecular structure of the human muscarinic receptor and applying screening to find drug…\nSurvey shows emergency physicians may benefit from training on safely handling firearms\n(Society for Academic Emergency Medicine) Emergency physicians may benefit from training on safely handling firearms, according to the findings of a survey to be published in the March 2020 issue of Academic Emergency Medicine (AEM), a journal of the S…\nRural Hondurans embrace cancer screening opportunities\n(Dartmouth-Hitchcock Medical Center) Few people in low-income countries have access to cancer screening and their cancer rates are on the rise. To test the feasibility of cancer screening in a low-income country, researchers from Dartmouth’s Norris Cot…\nPeople want more compensation, security for their genomic data\n(Cornell University) Genomic data donated by the public is valuable for the companies that collect it. But a recent survey finds that once people are aware of issues surrounding the use and security of genetic information, people are more concerned abo…\nProbing the genes that organize early brain development\n(University of Southern California) A new study finds how a specific gene can impact neurodevelopment and lead to macrocephaly and autism spectrum disorder in animal and lab models.\nSensing infection, suppressing regeneration\n(University of Illinois at Chicago) UIC researchers describe an enzyme that blocks the ability of blood vessel cells to self-heal. By studying mice with sepsis they found that removal of the enzyme allows cells to fully regenerate.\nBumblebees aversion to pumpkin pollen may help plants thrive\n(Cornell University) Cornell University researchers have found that squash and pumpkin pollen have physical, nutritional and chemical defense qualities that are harmful to bumblebees. The results of their recent study suggest that deterring bumblebees …", "label": "Yes"}
{"text": "At Turtle Point in Key West at SeaWorld, guests can see endangered and threatened species of sea turtles. These prehistoric-looking reptiles reside in a natural lagoon complete with a beach, sand dunes and indigenous plant life. SeaWorld Orlando has rescued and rehabilitated more than 300 sea turtles, ranging from tiny hatchlings to 4-foot-long leatherbacks.\nDuration - 7 minutes 0 seconds\nSuitability - Fun for Everyone, Outdoor\nAges - 4 thru 6 yrs, 7 yrs & up, 12 yrs & up, 0 thru 3 yrs, Family\nA'Lure The Call of the Ocean Blue Horizons Clyde and Seamore Take Pirate Island Dolphin Cove Dolphin Nursery Jazzy Jellies Journey to Atlantis Kraken Manatee Rescue Manta Net Climb Ocean Commotion One Ocean Pacific Point Preserve Penguin Encounter Pets Ahoy Reflections Sea Carousel Shamu Express Shamu Rocks Shark Encounter Sky Tower Stingray Lagoon Swishy Fishies The Flying Fiddler The Oyster's Secret Turtle Point TurtleTrek Wild Arctic", "label": "Yes"}
{"text": "Agriculture Plant Nursery - Case Study\nA plant nursery company had water quality issues from the well water source that there were using for irrigation purposes in their plant growing operations. These water quality issues including total dissolved salts (TDS) around 2500 mg/l, as well as turbidity, mineral hardness and microbiological contaminants. The plants were slow growing.\nGenesis Water Technologies consulted with the client on the best solution for this challenge. The system solution included pre-filtration, disinfection, anti-scalant followed by our GWT series reverse osmosis to reduce salts. Our specialized Agro-Z medium was used to enhance plant growth and reduce associated fertilizer nutrient costs.\nThe system was installed by a local contractor on site with technical and installation assistance provided by Genesis Water Technologies. The system is performing within its operating parameters with TDS levels less than < 200 TDS producing high quality water. The specialized Agro-Z medium is also providing enhanced benefits to the plants health and growth ensuring high quality plant yields.", "label": "Yes"}
{"text": "Harold ‘Poppy’ Jones\nHerbalist in Residence\nPoppy leads Earth-honoring nature walks both in New York City and on field trips. He is natural forager, herbal medicine maker and intuitive. He gives workshops on medicinal plants and herbs including identification, harvesting, and allowing students to observe the preparation of tinctures, compresses, teas and herbal baths. All of this work is informed by indigenous wisdom on holistic natural healing. At the Center, he maintains an herbal laboratory as part of our Rooftop Garden program, which allows him to instruct and assist students in the study of plants when not in the field. Poppy liaises with Original Caretakers friends and advisers, including those maintaining indigenous communities throughout the Northeast. Poppy joined CEE in 2016.", "label": "Yes"}
{"text": "- This event has passed.\nOrganic Chemistry Seminar Series: Vinayak Agarwal (Georgia Tech)\nMarch 28, 2022 | 3:45 pm - 4:45 pm\nAbout the Seminar:\nNatural products are organic secondary metabolites produced by all forms of life. In their native environment, natural products mediate intra- and interspecies communication. Bioinhibitory activities of natural products make them medicinally attractive– majority of clinically used drugs and pharmaceuticals are or are derived from natural products. The Agarwal laboratory seeks to understand how gene encoded enzymes construct natural product organic structures starting from simple biologically available starting materials. With the underlying motivation to reconstitute natural product biosynthetic pathways in the laboratory, we use a multidisciplinary approach involving metabolomics, (meta)genomics, enzymological assays, and structural biology to query the intricate enzymological chemistry which underlies natural product biosynthesis, and the metabolomic and genomic complexity of multi-organismal ecological niches in which natural products are produced. This seminar will highlight recent progress in three research directions: mass spectrometry-based identification of intermediates to reconstruct cryptic biosynthetic schemes, total in vitro reconstitution of polyketide synthases to reveal gatekeeping selectivity of ketosynthase domains, and the discovery and synthetic biological elaboration of an exceptionally widely distributed biosynthetic gene loci encoding brominated ribosomally synthesized and post-translationally modified peptide natural products.", "label": "Yes"}
{"text": "In this microscopic battle, it's survival of the biggest and hungriest...\nMove microbe 1-6 = Choose action ability (or click with mouse) Pause Eat the red proteins to grow and earn action abilities. Devour enemies smaller than you to grow and win!\nEmbed this game\nShare this game", "label": "Yes"}
{"text": "Contributors: marco mendoza, Maria B. Goncalves, Jonathan Corcoran\n... Differential gene expression analysis (RNA-sequencing) assessed in the SC from L5-SNL rats and non-injured rats, treated with vehicle or C286. Raw counts per gene (Raw counts.zip file) were normalized (quantile normalization; Normaliez counts.zip), then used for a differential gene expression analysis relative to the sample non-injured + vehicle (Diff_expression_DESeq2.zip). In addition, we have included herein a supplementary Table containing Gene Ontology (GO) terms per gene co-expression paths issued from the differential expression analysis. Notice that GO terms are described by their confidence of enrichment, expressend on \"-10*log10(p-value).\nContributors: Willem Roux, Imtiaz Gandikota, Guilian Yi\n... These are the computer models used for structural topology optimization from the paper \"A spatial kernel approach for topology optimization\" by Roux, Yi, and Gandikota.\nContributors: Hashem Ezzati\n... These are some codes and data constructed in Matlab software.\nTop results from Data Repository sources. Show only results like these.\nContributors: Jeremy Diem\n... These data were generated for an analysis of trends in satellite-based seasonal rainfall in western Uganda from 1983-2017. Western Uganda was divided into five rainfall regions. Analyses of the data show the following: (1) wet days in most seasons have a disproportionately high frequency of westerly back-trajectories extending over the Congo Basin; (2) rainy seasons, especially the first rains, have gotten longer and wetter throughout western Uganda; (3) rainfall also has increased for climatological seasons, with the exception being December-February; and (4) increases in middle-troposphere specific humidity and vertical ascent over time provide support for the wetting trends derived from the satellite-derived rainfall data.\nDataset for the metamodeling of naturally ventilated Brazilian low-cost houses to assess thermal performance\nContributors: Ana Paula Favretto, Camila Grassi, Michele Marta Rossi, Jeffrey Thomas, Yifan Yang, Joseph DeCarolis, Soolyeon Cho, David Hill, Ranji Ranjithan, Karin Chvatal\n... Research objective: This study aimed to develop metamodels to assess the thermal discomfort in naturally ventilated Brazilian low-cost houses during early design as a decision-making support framework, and for educational purposes. Method overview: The method encompassed a large number of simulations of the software EnergyPlus [EP] 8.1 using the Monte Carlo method. These simulations were used to develop a set of regression-based mathematical relationships between the inputs and the outputs. The Monte Carlo method was selected to help sample the many independent input variables, each with its own range of values, and form equally likely random combinations of input conditions for the energy simulation. The EnergyPlus outputs were post processed to assess the thermal comfort by means of the degree hours of discomfort by heat and by cold. Files description: The following data items were made available. (a) Parameter_Domains: Curitiba_parameterdomains.csv; Manaus_parameterdomains.csv and Sao_Paulo_parametersdomains.csv: CSV files created for each location. They contain a list of the 24 key parameters and random combinations of their values to create the input data for the 10,000 simulations. (b) Performance_Metrics: Curitiba_performancemetrics.csv; Manaus_performancemetrics.csv and Sao_Paulo_performancemetrics.csv: CSV files created for each location. They contain output values (outdoor and indoor discomfort by heat and by cold) for 10,000 simulations. (c) Sandbox: Sandbox.xlsx: Excel file for the application of the metamodels. It enables a quick and easy assessment of discomfort by heat and by cold for specific combinations of parameters, for each location. (d) Python_Codes: Python_Codes.zip: Compressed file consisting of the codes used to 1) run the simulations randomly combining values for each selected parameter within their specified ranges, and 2) to calculate the hours of discomfort by heat and by cold for each of the parameters’ combinations (10,000 simulations for each studied climate). (e) IDFs_Base: Curitiba_idfbase.idf; Manaus_idfbase.idf; Sao_Paulo_idfbase.idf : Input Data File (IDF) created for each location. They contain the description of all input data considered in an annual building performance simulation.\nContributors: Jonathan Long\n... Raw metabolomic data from acetonitrile/methanol-extracted livers transduced with the indicated AAV. LC-MS data were collected on an Agilent 6545 QTOF instrument in negative ionization mode.\nContributors: Tianjin Xie\n... Purple rapeseed leaves dataset contains training set and test set, both of which included RGB images which were cropped using UAV orthoimage and the corresponding labels, with the size of 256 × 256 pixels. The codes for the U-Net model used in this experiment was also assigned to the folder.\nFrom global-to-local? Uncovering the temporal dynamics of the composite face illusion using distributional analyses\nContributors: Daniel Fitousi\n... The data are the result of an experiment with composite faces. This is a standard composite face task in which a study and test composite faces are presented one after the other. The participant's task is to indicate whether the top half of the test and study faces are 'same' or 'different'. Both RTs and accuracy are measured.\nContributors: Bo Zhang, Feng Guo, Guoqing Wang, Xiaobing Zhang, Liang Zhao, Yangming Wu\nData for: The Surface Distributions of the Production of the Major Volatile Species, H2O, CO2, CO and O2, from the Nucleus of Comet 67P/Churyumov-Gerasimenko throughout the Rosetta Mission as Measured by the ROSINA Double Focusing Mass Spectrometer\nContributors: Michael Combi, Nicolas Fougere, Valeriy Tenishev, Yinsi Shou, Kenneth Hansen, Zhenguang Huang, David Marshall, Dominique Bockelee-Morvan, Martin Rubin, Kathrin Altwegg\n... The file MIRO_Columns.txt contains the column densities and their uncertainties corresponding to the results published previously in the paper by Marshall, D.W., Hartogh, P. Rezac, L. von Allmen, P., Biver, N., Bockelée-Morvan, D., Crovisier, J., Encrenaz, P. Bulkis, S. Hofstadter, M. Ip, W.-H., Jarchow, C. Lee, S., Lellouch, E. 2017. Spatially resolved evolution of the local H2O production rates of coet 67P/Churyumov,Gerasimenko, from the MIRO instrument of Rosetta. Astronomy & Astrophysics 603, A87. The format containes space delimited columns corresponding to Date, UT time, Heliocentric Distance (AU), column density (cm^-2), column density error (cm^-2).", "label": "Yes"}
{"text": "The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis\nNicodemus, K. K.\nMetadataShow full item record\nThis item's downloads: 0 (view details)\nCited 11 times in Scopus (view citations)\nHargreaves, A. Anney, R.; O'Dushlaine, C.; Nicodemus, K. K.; Gill, M.; Corvin, A.; Morris, D.; Donohoe, Gary; , ; , (2013). The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis. Psychological Medicine 44 (10), 2177-2187\nBackground. Genetic studies of single gene variants have been criticized as providing a simplistic characterization of the genetic basis of illness risk that ignores the effects of other variants within the same biological pathways. Of candidate biological pathways for schizophrenia (SZ), the cell adhesion molecule (CAM) pathway has repeatedly been linked to both psychosis and neurocognitive dysfunction. Here we tested, using risk allele scores derived from the Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), whether alleles within the CAM pathway were correlated with poorer neuropsychological function in patients. Method. In total, 424 patients with psychosis were assessed in areas of cognitive ability typically found to be impaired in SZ: intelligence quotient, memory, working memory and attentional control. CAM pathway genes were identified using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Alleles within these genes identified as significantly associated with SZ risk in the PGC-SCZ were then used to calculate a CAM pathway-based polygenic risk allele score for each patient and these scores were tested for association with cognitive ability. Results. Increased CAM pathway polygenic risk scores were significantly associated with poorer performance on measures of memory and attention, explaining 1-3% of variation on these measures. Notably, the most strongly associated single nucleotide polymorphism (SNP) in the CAM pathway (rs9272105 within HLA-DQA1) explained a similar amount of variance in attentional control, but not memory, as the polygenic risk analysis. Conclusions. These data support a role for the CAM pathway in cognitive function, both at the level of individual SNPs and the wider pathway. In so doing these data highlight the value of pathway-based polygenic risk score studies as well as single gene studies for understanding SZ-associated deficits in cognition.", "label": "Yes"}
{"text": "This article was originally published in Wisconsin Agriculturist\nWhy is it that dairy farms in my area are averaging under the Wisconsin average of 24,884 pounds of milk per cow? This question got me asking questions to some farmers and agri-service providers. One piece of the puzzle that emerged is that we may need to be paying closer attention to transition cows in our smaller herds. Care of the transition cow is not a new concept, but management strategies for the smaller farm may be overlooked when recommendations are shared.\nResearch shows that in the management of transition cows, dry matter intakes (DMI) are the key to a successful lactation. Appropriate DMI immediately prior to calving is critical as intake is naturally decreased due to fetal growth and hormone changes in late pregnancy. The goal is to prevent DMI from dropping, as long as possible, since the energy is critical for the health and production of the cow. Working with a nutritionist to define the energy in the diet is essential in this period as increased energy density could negatively affect DMI and/or digestion processes, but adequate energy is necessary to prevent the disruption of metabolic processes. The key lies in keeping the rumen filled with the correct diet that helps transition the rumen microbes to the diet the cow will be eating in lactation.\nFor smaller herds that might not have the facilities/space to make a transition group in the barn, you might have to get creative in making sure that cows in the transition period get the appropriate diet. For a tie-stall barn, this might mean grouping the handful of transition cows that you have at any given time next to each other to help with feeding the correct diet. You may need to prevent these cows from stealing the “normal” lactation diet being fed to the cow next to them by placing a board in the manger area as a divider between the two different diets. Alternatively, if there doesn’t seem to be space in the barn for the transition cows, pasture or dry-lot space with a shelter may provide another management strategy to get the correct diet to these cows.\nResearch also shows that environmental stressors, including social stress, can affect cow access to bunk space and feed, which can lower DMI. For herds that have a penning system, and pen space to dedicate to transition cows, there are a couple of grouping strategies to keep in mind with transition cows. One strategy is to group cows within a set anticipated calving date together with no new animals entering the pen until all cows have calved (all-in, all-out). An alternative strategy is to move cows in pairs if you must make changes in pens as it takes about four days for the social order to be stabilized after grouping changes are made.\nReferences available upon request", "label": "Yes"}
{"text": "Sarban Singh, The Star | May 25, 2021\nMalaysians are aghast over the culling of some 20 dusky langurs in Port Dickson and are demanding answers from the authorities.\nAnimal lovers and wildlife experts have decried the decision allegedly taken by officers from the Wildlife and National Parks Department (Perhilitan) to cull them, arguing that other methods should have been employed to deal with the primates which were not known to be aggressive.\nSome 20 dusky langurs, believed to be from the same family, were apparently shot dead near a residential area last Wednesday.\nIn a joint statement, the Malaysian Primatological Society and Langur Project Penang said such drastic action was unnecessary as aggression by dusky langurs, protected under the Wildlife Conservation Act 2010, was extremely rare.\nThey said that dusky langurs were an extremely shy and gentle primate, and under normal circumstances, preferred the sanctuary of the forest rather than seeking to be near human settlements, unlike macaques.\nAll parties, they added, must develop a culture of respect for wildlife in urban spaces.\nAlong with other native Malaysian wildlife, they said dusky langurs were an important part of our natural heritage, and were widely promoted in ecotourism and wildlife watching activities.\nLawyers for Animal Rights asked how could an endangered species be shot en masse.\nAnimal rights activist and lawyer Rajesh Nagarajan said Perhilitan and the police must investigate the incident under the Animal Welfare Act 2015.\n“We demand that Perhilitan investigate and prosecute every single officer who is complicit in this barbaric murder of poor defenceless creatures, ” he said.\nInternational photojournalist author and publisher David S.T. Loh also described the incident as shocking.\n“Langurs are such gentle herbivores. They are shy, timid and generally will run away when humans approach them.\n“With all my travelling within Malaysia, I have yet to see one aggressive langur. It is shocking that Perhilitan shot dead a family of an endangered species, ” he said, adding that he found it difficult to believe that these harmless primates would attack people.\nSave a Stray Malaysia founder Jacqueline Tsang said the department might have acted hastily in this instance.\n“Their action is tantamount to being trigger-happy. There surely is an alternative to culling, ” she said when contacted.\nGibbon Conservation Society president Mariani Ramili said the culling of primates did not solve problems, and that Perhilitan should collaborate with experts from non-governmental wildlife organisations to revise and enforce wildlife management policies.\n“Unfortunately, this is not the first human-wildlife conflict is handled with culling. We have already lost our Sumatran rhino, and are struggling to conserve our Malayan Tiger, so how can we kill our other wildlife species?” she asked.\nMalaysian Nature Society president Prof Ahmad Ismail said although Perhilitan might have been acting on a public complaint, it should have looked at other options rather than killing animals listed as endangered.\nAttempts to get a response from Perhilitan director-general Datuk Abdul Kadir Abu Hisham were unsuccessful, although queries were sent last Friday.", "label": "Yes"}
{"text": "Women and men differ in their chromosomal makeup, protein gene products, genomic imprinting, gene expression, signaling pathways, and hormonal environment. All of these necessitate caution in extrapolating information derived from biomarkers from one sex to the other. Women are particularly vulnerable at the two extremes of life. Young women and adolescents are at risk from STIs, pregnancy and unsafe abortion, while older women often have few resources and are disadvantaged with respect to men, and also are at risk of dementia and abuse, and generally poor health.\nWomen have traditionally been disadvantaged in terms of economic and social status and power, which in turn reduces their access to the necessities of life including health care. Despite recent improvements in western nations, women remain disadvantaged with respect to men. The gender gap in health is even more acute in developing countries where women are relatively more disadvantaged. In addition to gender inequity, there remain specific disease processes uniquely associated with being a woman which create specific challenges in both prevention and health care.\nBy contrast, ovarian cancer, the leading cause of reproductive organ cancer deaths, and the fifth commonest cause of cancer deaths in women in the United States, lacks an effective screening programme, and is predominantly a disease of women in industrialised countries. Because it is largely asymptomatic in its earliest stages, more than 50% of women have stage III or higher cancer (spread beyond the ovaries) by the time they are diagnosed, with a consequent poor prognosis.\nOur review found that protein-energy supplementation was largely targeted to pregnant and lactating women (19, 86–88, 90, 91); however, there were some studies that evaluated the delivery of protein-energy supplementation to households (92, 93) and adolescents (46). The only studies we found that evaluated the impact of protein-energy supplementation in older, healthy women were hospital-based studies in high-income countries (96). Delivery platforms varied depending on the target audience. The majority of studies targeted pregnant women through antenatal care or through antenatal care–associated community-based programs. National programs targeting low-income families had broader reach, although they targeted households and not women specifically (92). Additional research is needed for how women might best be reached (94). For programs that provided provisions for women to take home, there was also limited information about how much was shared with other members of the household. School-based programs targeting adolescents could be an important venue to target interventions to adolescents in the future. However, children and adolescents not in school would be missed. Despite limited evidence of impacts of energy and protein supplementation on the health of women, supplementation might be an important complement to other interventions (e.g., nutrition education and counseling) to ensure that women have the resources needed to implement other interventions successfully. Indeed, many large-scale programs for protein-energy supplementation are often complemented with nutrition education and counseling (33).\nWomen and men have approximately equal risk of dying from cancer, which accounts for about a quarter of all deaths, and is the second leading cause of death. However the relative incidence of different cancers varies between women and men. In the United States the three commonest types of cancer of women in 2012 were lung, breast and colorectal cancers. In addition other important cancers in women, in order of importance, are ovarian, uterine (including endometrial and cervical cancers (Gronowski and Schindler, Table III). Similar figures were reported in 2016. While cancer death rates rose rapidly during the twentieth century, the increase was less and later in women due to differences in smoking rates. More recently cancer death rates have started to decline as the use of tobacco becomes less common. Between 1991 and 2012, the death rate in women declined by 19% (less than in men). In the early twentieth century death from uterine (uterine body and cervix) cancers was the leading cause of cancer death in women, who had a higher cancer mortality than men. From the 1930s onwards, uterine cancer deaths declined, primarily due to lower death rates from cervical cancer following the availability of the Papanicolaou (Pap) screening test. This resulted in an overall reduction of cancer deaths in women between the 1940s and 1970s, when rising rates of lung cancer led to an overall increase. By the 1950s the decline in uterine cancer left breast cancer as the leading cause of cancer death till it was overtaken by lung cancer in the 1980s. All three cancers (lung, breast, uterus) are now declining in cancer death rates (Siegel et al. Figure 8), but more women die from lung cancer every year than from breast, ovarian, and uterine cancers combined. Overall about 20% of people found to have lung cancer are never smokers, yet amongst nonsmoking women the risk of developing lung cancer is three times greater than amongst men who never smoked.\nA workout partner not only keeps you accountable, she also may help you clock more time at the gym and torch more fat. A British survey of 1,000 women found that those who exercise with others tend to train six minutes longer and burn an extra 41 calories per session compared to solo fitness fanatics. [Tweet this fact!] Women with Bikram buddies and CrossFit comrades said they push themselves harder and are more motivated than when they hit the gym alone.\nImportant sexual health issues for women include Sexually transmitted infections (STIs) and female genital cutting (FGC). STIs are a global health priority because they have serious consequences for women and infants. Mother-to-child transmission of STIs can lead to stillbirths, neonatal death, low-birth-weight and prematurity, sepsis, pneumonia, neonatal conjunctivitis, and congenital deformities. Syphilis in pregnancy results in over 300,000 fetal and neonatal deaths per year, and 215,000 infants with an increased risk of death from prematurity, low-birth-weight or congenital disease.\nThe delivery of nutrition education reached women across all life stages and through many platforms. Many nutrition education studies that targeted pregnant and lactating mothers reported on women's outcomes, but the primary focus of many of these studies was child health outcomes (13, 14, 19, 21, 24, 28); few studies focused on dietary outcomes and behaviors of pregnant and lactating women themselves (17, 20, 23). There were some studies evaluating the impact of nutrition education on the practices and outcomes of school-age children and adolescent girls (15, 18, 27, 29, 34), as well as older women (16, 22, 25, 30). Many of the nutrition education interventions were clinic-based (17–20, 23, 24). However, nutrition education was also delivered through community-based programs, including home visits (16, 21), community centers (15, 16, 20, 21), worksites (25), and schools (25, 27, 30, 34).\nLow-fat diets also can help you lose weight.16 But the amount of weight lost is usually small. You can lose weight and lower your risk for heart disease and stroke if you follow an overall healthy pattern of eating that includes more fruits, vegetables, whole grains and beans that are high in fiber, nuts, low-fat dairy and fish, in addition to staying away from trans fat and saturated fat.\nMicrocredit institution NC HH food security, NC individual food security, NC food expenditures, NC food consumption, ↑ social status, ↑ self-confidence ↑ health knowledge, NC health status, NC HH food security, NC individual food security, ↑/NC food expenditures, NC food consumption, NC school enrollment, ↑/NC empowerment, ↑ self-confidence, ↑/NC decision-making, ↑ social status, ↑/NC health care utilization ↑ health knowledge, NC health status, ↑/NC food expenditures, NC school enrollment, ↑/NC empowerment, ↑/NC decision-making power, ↑ self-confidence, ↑/NC health care utilization NC health status, ↑/NC food expenditures, ↑/NC empowerment, ↑/NC decision-making power, ↑ self-confidence, NC health care utilization\nA related issue is the inclusion of pregnant women in clinical studies. Since other illnesses can exist concurrently with pregnancy, information is needed on the response to and efficacy of interventions during pregnancy, but ethical issues relative to the fetus, make this more complex. This gender bias is partly offset by the iniation of large scale epidemiology studies of women, such as the Nurses' Health Study (1976), Women's Health Initiative and Black Women's Health Study.\nIt doesn't matter how many pushups you can do in a minute if you're not doing a single one correctly. “There is no point in performing any exercise without proper form,” says Stokes, who recommends thinking in terms of progression: Perfect your technique, then later add weight and/or speed. This is especially important if your workout calls for performing “as many reps as possible” during a set amount of time. Choose quality over quantity, and you can stay injury-free.\nThe prevalence of Alzheimer's Disease in the United States is estimated at 5.1 million, and of these two thirds are women. Furthermore, women are far more likely to be the primary caregivers of adult family members with depression, so that they bear both the risks and burdens of this disease. The lifetime risk for a woman of developing Alzeimer's is twice that of men. Part of this difference may be due to life expectancy, but changing hormonal status over their lifetime may also play a par as may differences in gene expression. Deaths due to dementia are higher in women than men (4.5% of deaths vs. 2.0%).\nWomen's empowerment relates to women's ability to make life choices (158). Higher levels of empowerment were associated with increased income, household decision-making, control over resources, and utilization of health resources (5, 158–160). For nutrition outcomes, empowerment was associated with increased income allocated to food expenditures and improved household food security (160, 161). It was also associated with increased dietary diversity, but had no impact on women's BMI (5, 161, 162). For example, mothers’ participation in empowerment activities through Helen Keller International's Enhanced Homestead Food Production (EHFP) program in Burkina Faso was associated with increased fruit intake (difference-in-differences = 15.8 percentage points, P = 0.02) and nearly statistically significant increases in meat intake and dietary diversity (163). Participation was also associated with decreased prevalence of underweight (difference-in-differences = −8.7 percentage points, P < 0.01) but not overall mean BMI (163). In addition, the EHFP program in Bangladesh and Nepal was associated with decreasing trends in maternal anemia (anemia prevalence decreased by a magnitude of 12%, P = 0.075 in Bangladesh, and 26%, P = 0.009 in Nepal) (160). However, this was not consistent with findings from Cambodia (160).\nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact firstname.lastname@example.org\nAs women, many of us are prone to neglecting our own dietary needs. You may feel you’re too busy to eat right, used to putting the needs of your family first, or trying to adhere to an extreme diet that leaves you short on vital nutrients and feeling cranky, hungry, and low on energy. Women’s specific needs are often neglected by dietary research, too. Studies tend to rely on male subjects whose hormone levels are more stable and predictable, thus sometimes making the results irrelevant or even misleading to women’s needs. All this can add up to serious shortfalls in your daily nutrition.\nDelivery platforms for women across the life course. This Venn diagram represents the delivery platforms for different interventions by target population. The overlapping regions indicate delivery platforms that are shared by the target groups: adolescent girls, women of reproductive age, pregnant and lactating women, mothers of young children, and older women.\nWe cater to every fitness need — and you’ll find everything from cardio equipment and strength training — to small group training classes like Tribe and youth fitness programs. Burn calories with high intensity group exercise, cycling or circuit training workouts, or enjoy the low impact mindfulness of our many yoga classes, hot yoga and Pilates. Amenities also include private locker room facilities with dry saunas and onsite childcare.\nCommunity centers NC HH or individual food security, NC food expenditures, NC food consumption, ↑ social status, ↑ self-confidence ↑ health and knowledge, ↓ anemia, ↑/NC HH food security, NC individual food security, NC food expenditures, ↑/NC food consumption, ↑/NC dietary diversity, ↑ MN-rich foods (Fe, vitamin A, vitamin C, calcium), ↑/NC intake of protein, ↑ ASF intake, ↑/NC BMI, ↑ weight gain, ↑ social status, ↑ self-confidence, ↑/NC decision-making ↑ health and nutrition knowledge, ↓/NC anemia, ↑/NC HH food security, ↑/NC food expenditures, ↑/NC HH food consumption, ↑/NC dietary diversity, ↑ nutrient-rich foods (Fe, vitamin A), NC intake of protein, ↑/NC intake of vegetables and ASF, ↑/NC BMI, ↓ underweight, ↑ weight gain, NC diarrheal morbidity, ↑ self-confidence, ↑/NC decision-making, ↑ control HH resources ↑ health knowledge, ↑/NC HH food security, ↑/NC HH food consumption, ↑ dietary diversity, ↑ self-confidence, ↑/NC decision-making\nComplementing income-generating interventions with interventions that more directly target women's nutrition has potential to have greater impacts on women's nutritional status (171). Integrated interventions were associated with improvements in health knowledge and behaviors, as well as increased intake of nutrient-rich foods (5, 164, 169, 170, 172). In Bangladesh and Cambodia, the aforementioned EHFP program was associated with increased income, decision-making power in the household, food expenditure (including on oils, salts, spices, fish, rice, and meat), and consumption of fruits and vegetables from home gardens (160, 173). There was also limited, but mixed, evidence of income-generating interventions and behavior change communication causing improvements in maternal anemia and BMI (164, 168, 170).\nRecent research by the Centers for Disease Control and Prevention showed that ART babies are two to four times more likely to have certain kinds of birth defects. These may include heart and digestive system problems, and cleft (divided into two pieces) lips or palate. Researchers don't know why this happens. The birth defects may not be due to the technology. Other factors, like the age of the parents, may be involved. More research is needed. The risk is relatively low, but parents should consider this when making the decision to use ART.\nAs the science of nutrition continually evolves, researchers recognize that nutrients needed to maintain a healthy lifestyle must be tailored to the individual for maximum effectiveness. Recognizing that people are not all alike and that one size does not fit all when it comes to planning and achieving a healthful diet, the Institute of Medicine's dietary guidelines, titled \"Dietary Reference Intakes for Macronutrients,\" stress the importance of balancing diet with exercise and recommends total calories based on an individual's height, weight and gender for each of four different levels of physical activity.\nHysterosalpingography (HIS-tur-oh-sal-ping-GOGH-ru-fee): This is an x-ray of the uterus and fallopian tubes. Doctors inject a special dye into the uterus through the vagina. This dye shows up in the x-ray. Doctors can then watch to see if the dye moves freely through the uterus and fallopian tubes. This can help them find physical blocks that may be causing infertility. Blocks in the system can keep the egg from moving from the fallopian tube to the uterus. A block could also keep the sperm from reaching the egg.\nIn order to complete your transaction, we will share the name, billing and shipping address and other order information associated with your purchase with the publisher or magazine vendor. Your name and address will also be shared with a circulation-auditing organization. We may share your e-mail with the publisher, but you can control how it will be used in Subscription Manager. We will not share your credit card information. Offers on this page are introductory. See Details.\nThe new guidelines encourage eating more nutrient-dense food and beverages. Many of us consume too many calories from solid fats, added sugar and refined grains. The guidelines promote a diet that emphasizes vegetables, fruits, whole grains, fat-free or low-fat dairy products, seafood, lean meat and poultry, eggs, beans and peas, and nuts and seeds.\nIt has affected more than 200 million women and girls who are alive today. The practice is concentrated in some 30 countries in Africa, the Middle East and Asia. FGC affects many religious faiths, nationalities, and socioeconomic classes and is highly controversial. The main arguments advanced to justify FGC are hygiene, fertility, the preservation of chastity, an important rite of passage, marriageability and enhanced sexual pleasure of male partners. The amount of tissue removed varies considerably, leading the WHO and other bodies to classify FGC into four types. These range from the partial or total removal of the clitoris with or without the prepuce (clitoridectomy) in Type I, to the additional removal of the labia minora, with or without excision of the labia majora (Type II) to narrowing of the vaginal orifice (introitus) with the creation of a covering seal by suturing the remaining labial tissue over the urethra and introitus, with or without excision of the clitoris (infibulation). In this type a small opening is created to allow urine and menstrual blood to be discharged. Type 4 involves all other procedures, usually relatively minor alterations such as piercing.\nEveryone seems to have food allergies these days, but in fact, such allergies are rare. According to the National Institute of Allergy and Infectious Diseases, while one in three adults think they have a food allergy or modify their family's diet, only about four percent do. A food allergy is an abnormal immune-system response to certain foods (most commonly, fish, shellfish, peanuts, other nuts and eggs). Symptoms can include hives, rashes, nasal congestion, nausea, diarrhea and gas. However, symptoms of food intolerance—such as intestinal distress—may mimic those of a food allergy. You may want to talk to an allergist about diagnosis and treatment. Whether you have food allergies or intolerance, you will need to develop a diet that fits your needs and avoids foods that trigger a reaction.\nThe U.S. Department of Agriculture's (USDA) food pyramid system (www.mypyramid.gov) provides a good start by recommending that the bulk of your diet come from the grain group—this includes bread, cereal, rice and pasta— the vegetable group; and the fruit group. Select smaller amounts of foods from the milk group and the meat and beans group. Eat few—if any—foods that are high in fat and sugars and low in nutrients. The amount of food you should consume depends on your sex, age and level of activity.\nYou don’t have to spend a lot of money, follow a very strict diet, or eat only specific types of food to eat healthy. Healthy eating is not about skipping meals or certain nutrients. Healthy eating is not limited to certain types of food, like organic, gluten-free, or enriched food. It is not limited to certain patterns of eating, such as high protein.\nNutrition education Health clinics ↑ knowledge, NC Hgb, ↑ intake of fruits and vegetables, ↓/NC intake of fats, sweets, and sugar-sweetened beverages ↑ knowledge, NC Hgb, ↑ intake of fruits and vegetables, ↓/NC intake of fats, sweets, and sugar-sweetened beverages ↑ knowledge, NC urinary iodine, ↑ intake of nutrient-rich foods, ↑ intake of protein, ↑ weight gain, ↑/NC weight loss postpartum (obese women) with diet and exercise\nGrains, vegetables and fruits are essential to getting the vitamins, minerals, complex carbohydrates (starch and dietary fiber) and other nutrients you need to sustain good health. Some of these nutrients may even reduce your risk of certain kinds of cancer. But experts say we rarely eat enough of these foods. To make matters worse, we also eat too much of unhealthy types of food, including fat (and cholesterol), sugar and salt.\nIf you usually head to the gym after work, take heed: Mental exhaustion can make you feel physically exhausted, even when you have plenty of energy, reports a Medicine & Science in Sports & Exercise study. When people played a brain-draining computer game before exercising, they reported a subsequent workout as being harder, yet their muscles showed the same activity as they did doing the same workout after an easy mental game. So if you think you can’t eke out those last 10 minutes on the rowing machine, remember: You can! [Tweet this motivation!]\nAdopting a plant-based diet could help tip the scales in your favor. A five-year study of 71,751 adults published in the Journal of the Academy of Nutrition and Dietetics found that vegetarians tend to be slimmer than meat-eaters even though both groups eat about the same number of calories daily. Researchers say it may be because carnivores consume more fatty acids and fewer weight-loss promoting nutrients, like fiber, than herbivores do. Go green to find out if it works for you.", "label": "Yes"}
{"text": "Facts About Sugar Maple Trees\nSugar maples grow in much of the Northern hemisphere. These trees have distinctive flower and bark characteristics, grow better in certain soil conditions and are subject to several types of hazards. People use sugar maple trees for producing many...\nAcer saccharum is a species of maple native to the hardwood forests of eastern\nCanada, from Nova Scotia west through Quebec and ...\nSugar Maple (hard maple, rock maple). Sugar maple (Acer saccharum) is the\nmost abundant of the seven maple species found in New York State, and is ...\nThe electric reds, golds and oranges of sugar maple's (Acer saccharum) dying\nfoliage fuel New England's fiery autumnal displays, months before countless ...\nInformation about the Sugar Maple. ... The sugar maple (hard maple, rock maple)\nis one of our largest and finest forest trees, growing to a feet with a ... Fun Facts:.\nThe tree Guide at arborday.org offers information on size, height, growth rate, sun\nand soil preference, and more on Sugar Maple and many other commonly ...\nJun 2, 2014 ... INTERESTING FACTS ABOUT MAPLE TREES. Sugar, Black, and Red maples\nare the trees that are important for maple syrup production.\nMaple tree is plant that belongs to the family Aceraceae. ... Maple tree Facts ...\nMaple syrup is rich in sugar, but it also contains vitamins and minerals in traces.\nCounties in blue contain tree ... Sugar maple, also known as hard maple or rock\nmaple, is a medium to large tree, from 70 to 90 feet tall. ... Interesting Facts.\nSugar Maple Acer saccharum. In spring, the numerous yellow flowers give this\ntree a distinctive appearance. The tree grows well in fertile, moist, and ...", "label": "Yes"}
{"text": "Approximately 1.5 million calves are reared each year in NZ – 1 million dairy heifers and 500,000 bull calves. The dairy heifers are future herd replacements and how they are reared will affect how they grow and what weight they enter the herd. This website provides independent advice to New Zealand calf rearers. Information on this site has been put together by staff at On-Farm Research who have been involved with calf rearing research at the Poukawa Research Farm since 1996.\nInformation (On-Farm Research Fact Sheets) can be accessed from drop-down menus on each page and via the library.The library also has a wide range of information, media articles, video links and links to other useful websites.\nEvery effort is being made to ensure the information available on the site is accurate and un-biased. We do not sell or endorse products.", "label": "Yes"}
{"text": "Wild Ginger, Asarum canadense, is a common spice of the woods that can be made into candy. It was used medicinally as a cough medicine, febrifuge, anti-convulsive, abortifacient, pain-reliever, antiemetic, ear ache medicine and a perfume.\nWild Ginger Sources:\nAudubon Guides Box Set – Birds, Tree, Wildflowers & Mammals. Computer Software.Green Mountain Digital. Version: 2.3. Web. Jul 10, 2014.\nBrill, Steve. Wild Edibles Plus. Computer Software. WinterRoot LLC. Version 1.5. 2012. Web. Feb. 15, 2014.\nFelter, Harvey Wickes, M.D., and John Uri Lloyd, Phr. M., Ph. D. King’s American Dispensatory, Vol. 1. Cincinnati: The Ohio Valley Company, 1905. pg. 287\nFoster, Steven and James A. Duke. The Peterson Field Guide Series; A Field Guide to Medicinal Plants and Herbs of Eastern and Central North America. 2nd. ed. Boston: Houghton Mifflin Company, 2000. Print. pg. 155-156\nHamel, Paul B. and Mary U. Chiltoskey. Cherokee Plants and Their Uses- A 400 Year History. North Carolina: Herald Publishing. 1975. Print. pg. 36\nHerrick, James William. Iroquois Medical Botany. Ph.D. Thesis, New York: State University of New York, Albany 1977. Print. pg. 93, 49, 52, 55-56, 67, 115-116\nMoerman Daniel E., Native American Ethnobotany, Portland: Timber Press. 1998. Print. pg. 105-106\nNewcomb, Lawrence. Newcomb’s Wildflower Guide. Boston: Little, Brown and Company, 1977. Print. pg. 116-117\nPeterson, Lee Allen. The Peterson Field Guide Series; A Field Guide to Edible Wild Plants; Eastern and Central North America. Boston: Houghton Mifflin Company, 1977. Print. pg. 96-97, 160-161\nUnited States Department of Agriculture. Natural Resources Conservation Services. Web.\nThis will always be one of my favorite plants to find (because I can identify it by the color) and cook with too!\nterry b says\nI love your web site. I especially like the native peoples uses for wild edibles. I have finally found a very annoying grass like weed in my yard. your site was the only one to identify it. behold, I have another edible in my lawn, I’m excited to harvest all the wild plants in my yard. thanks for all the information, pictures I can actually see to identify and the helpful blogs. honestly, I never knew there were so many ways to build a poncho lean too! wow! I’ll be watching your site. thanks again\nLol, thanks for the compliment I’m glad you like the site.\nAndrew Lawrence says\nAnyone concerned about the known carcinogen content?", "label": "Yes"}
{"text": "Sera from Guillain-Barré patients enhance leakage in blood-nerve barrier model\nAutor(es): Kanda Takashi,Yamawaki Masanaga,Mizusawa Hidehiro\nResumo: In Guillain-Barré syndrome (GBS), the destruction or malfunction of blood-nerve barrier (BNB) has been considered to be the beginning of the disease process. It is unclear whether sera from patients with GBS can open the BNB, and which component of patient sera is most important in the dysregulation of the BNB. The authors evaluated the effect of sera from patients with GBS on permeability of an in vitro BNB model using bovine endoneurial microvascular endothelial cells (PnMEC) cultured on the luminal side of a collagen-coated culture insert (pore size: 0.4 micro m). PnMEC monolayers challenged by GBS sera showed significantly lower transendothelial electrical resistance and higher clearance of [carboxyl-(14)C]-inulin with or without complement. Sera with anti-GM1 antibody showed greater loosening of the barrier than others. This effect decreased significantly after incubation with pure GM1 antigen, suggesting the importance of anti-GM1 antibody in BNB dysregulation. Serial analyses of [carboxyl-(14)C]-inulin clearance in four patients disclosed a favorable effect of plasmapheresis in restoring BNB function in some cases. The authors found an unfavorable effect of sera from patients with GBS on BNB function, supporting involvement of humoral factors causing BNB derangement in the acute stage. Serial evaluation of permeability change using the authors' in vitro system might be useful for the clinical assessment of BNB derangement in individual patients.\nImprenta: Neurology, v. 60, n. 2, p. 301-306, 2003\nIdentificador do objeto digital: 10.1212/01.WNL.0000041494.70178.17\nDescritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health\nData de publicação: 2003", "label": "Yes"}
{"text": "A bacterium that degrades and assimilates poly(ethylene terephthalate)Shosuke Yoshida, Kazumi Hiraga, Toshihiko Takehana, Ikuo Taniguchi, Hironao Yamaji, Yasuhito Maeda, Kiyotsuna Toyohara, Kenji Miyamoto, Yoshiharu Kimura, Kohei Oda\nSome bacteria think plastic is fantastic\nBacteria isolated from outside a bottle-recycling facility can break down and metabolize plastic. The proliferation of plastics in consumer products, from bottles to clothing, has resulted in the release of countless tons of plastics into the environment. Yoshida et al. show how the biodegradation of plastics by specialized bacteria could be a viable bioremediation strategy (see the Perspective by Bornscheuer). The new species, Ideonella sakaiensis , breaks down the plastic by using two enzymes to hydrolyze PET and a primary reaction intermediate, eventually yielding basic building blocks for growth.\n, this issue p.", "label": "Yes"}
{"text": "How late can you plant wheat?\nThe rains have slowed wheat planting in a lot of areas, but we still have the potential for a good crop! Planting within the first 10 days after the recommended fly-free is normally our goal, but we can plant wheat up to one month after the fly-free date and still maintain optimal yields.\nWhen should I plant winter wheat?\nWinter wheat is planted in the fall and harvested in the summer. It needs a good root system and the beginnings of shoots before cold weather sets in. Spring wheat is planted in early spring, as soon as possible, and harvested in late summer.\nCan you plant winter wheat in August?\nWinter wheat planted during the summer months will not head out until undergoing vernalization during the winter months. Field peas planted with the winter wheat will not regrow after fall cutting but greatly enhance quality of the forage harvested the first year.\nCan winter wheat be planted in January?\nPlanting dates from October 1 through January 1 provided yields of 50%-100% of full yields. Wheat planted on all dates through March 1 headed and produced grain yields each year.\nHow late is too late for winter wheat?\nWinter wheat can be seeded up until about February 15 in southeast Nebraska and about March 15 in northwest Nebraska and still give the seed time to vernalize. Four to six weeks of freezing temperatures at night are required for vernalization. Some varieties have shorter vernalization requirements.\nCan I plant wheat in May?\nIncreased growth during the early season typically results in higher yields. For example, a study in North Dakota showed that spring wheat planted on May 1st had six fewer days of growth from emergence to 6-leaf stage when compared to wheat planted on April 15th. … However, this can vary greatly from season to season.\nWhat can you plant after winter wheat?\nCover crop choices following winter wheat\n- Crimson Clover – Rapid growing winter annual good for short windows. …\n- Field/Winter Pea – Cool season annual, very rapid growth, good for short windows. …\n- Red Clover – Short-lived perennial, with very good heat and drought tolerance.\nHow late can you plant winter wheat in Wisconsin?\nThe Wisconsin winter wheat final planting date varies by county, ranging from September 30th to October 10th. If the wheat is seeded after the county’s final plant date (late planting period) the crop insurance guarantee is reduced by 1% per day for the first 10 days.\nCan you sow winter wheat in spring?\nAlthough it’s not a common practice, winter wheat can be planted in the spring as a weed-suppressing companion crop or early forage. You sacrifice fall nutrient scavenging, however. Reasons for spring planting include winter kill or spotty overwintering, or when you just didn’t have time to fall-seed it.\nCan you plant winter wheat in November?\nA late-planted wheat crop has less time to put on fall tillers, which are proven to be more productive than spring tillers. … To compensate for this, scientists agree that farmers should increase the seeding rate on wheat fields planted in late October and November.\nWill winter wheat reseed itself?\nOr it will eventually seed itself out, although in my experience with food plots, birds and turkeys will have eaten about 99.367% of the seed before it ever hits the ground.\nWhat happens if you plant winter wheat too early?\nBy planting wheat early, you provide a longer window for infection in the fall as well as a longer time for the disease to develop before winter. Both of these factors increase the incidence and severity of the disease. Also, the risk of multiple infections by more than one virus is greater.", "label": "Yes"}
{"text": "The Rare Birds of Southern Africa by P.A. Clancey\nPublisher: Winchester Press, 1985\nHard cover, 512 pages\nSecond Hand, Good condition. Torn Jacket cover\nThe Rare Birds of Southern Africa by P A Clancey is the showcase for 94 of the rarest (and most vulnerable) birds to be found in southern Africa. It includes 74 colour illustrations and distribution maps of the birds mentioned.", "label": "Yes"}
{"text": "Dynamics of Multi-strain Age-structured Model for Malaria Transmission\nMetadataShow full item record\nThe thesis is based on the use of mathematical modeling and analysis to gain insightinto the transmission dynamics of malaria in a community. A new deterministic model for assessing the role of age-structure on the disease dynamics is designed. The model undergoes backward bifurcation, a dynamic phenomenon characterized by the co-existence of a stable disease-free and an endemic equilibrium of the model when the associated reproduction number is less than unity. It is shown that adding age-structure to the basic model for malaria transmission does not alter its essential qualitative dynamics. The study is extended to incorporate the use of anti-malaria drugs. Numerical simulations of the extended model suggest that for the case when treatment does not cause drug resistance (and the reproduction number of each of the two strains exceed unity), the model undergoes competitive exclusion. The impact of various effectiveness levels of the treatment strategy is assessed.", "label": "Yes"}
{"text": "Background: Pulmonary hypertension (PH) is a severe disease characterized by a progressive\nincrease in pulmonary vascular resistance, initially due to abnormal pulmonary vasoconstriction in\nresponse to endothelial and smooth muscle cells injury. The discovery of new chemical entities having a\nprotective effect on pulmonary artery cells could be meaningful for the treatment of PH.\nMethods: We evaluated the protective effect of DL0805 derivatives (DL0805-1 and DL0805-2) on\npulmonary artery vascular cells, including human pulmonary artery endothelial cells (HPAECs) and\nhuman pulmonary artery smooth muscle cells (HPASMCs). DL0805 derivatives are novel ROCKs\n(Rho-associated coiled-coil forming protein serine/threonine kinases) inhibitors. Treatment of HPAECs\nwith DL0805-2 (10 μM) cultured under a hypoxic environment could significantly reduce the proliferation\nof cells. Meanwhile, the compounds inhibited the production of reactive oxygen species (ROS) in\nHPAECs at every dose tested.\nResults: A Western Blot experiment showed that the protective effect of DL0805 derivatives might\nresult from the down-regulation of RhoA (Ras homolog gene family, member A) expression and the\ninhibition of ROCKs activity. In addition, the compounds inhibited the proliferation of HPASMCs induced\nby fetal bovine serum (FBS) or platelet derived growth factor BB (PDGF-BB), and suppressed\nthe F-actin remodeling induced by endothelin.\nConclusion: The preliminary results from an immunofluorescence assay showed that DL0805 derivatives\ninhibited the activity of ROCKs in HPASMCs. The above mentioned results indicated that\nDL0805 derivatives have a protective effect on pulmonary artery cells, and the underlying mechanisms\nmight be the result of inhibition of RhoA/ROCK signaling pathway.", "label": "Yes"}
{"text": "A chemical used in the production of toilet paper and ‘forever chemicals’ have been found in the bodies of orcas in B.C. , including the endangered southern resident killer whales. Scientists analyzed tissue samples from six southern resident killer whales and six Bigg’s whales stranded along the coast of B.C. from 2006 to 2018, according to a recent study. They discovered that chemical pollutants are prevalent in killer whales, with a chemical often found in toilet paper one of the most prevalent in the samples studied, accounting for 46 per cent of the total pollutants identified.", "label": "Yes"}
{"text": "2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Induced Weight Loss: A Proposed Mechanism\nTCDD caused a dose-related decrease in body weight, food intake, motor activity and total and resting oxygen consumption in rats. In animals treated with 15 μg/kg, the depression in food intake and oxygen consumption lasted 2 weeks. Thereafter, the rats consummed the appropriate amounts of food and oxygen for their reduced weights. However, in rats treated with 50 μg/kg, food intake was insufficient to maintain weight. The results suggest that TCDD causes weight loss by a decrease in energy intake (as opposed to an increase in energy expenditure). The decrease in intake of energy could be due to mal-absorption of nutrients from the gastrointestinal tract and/or reduced food intake. Of these, reduction in food consumption is considered to be the main factor involved. This is because weight in pair-fed control rats stabilizes at a level only slightly higher than in TCDD- treated animals. To determine if TCDD is altering a regulatory system for body weight (as opposed to a system controlling food intake), rats had their body weights reduced by food restriction prior to TCDD (25 μg/kg). Immediately after TCDD they were given food ad lib and they exhibited hyperphagia and weight gain. Thus, the ability to feed is not directly inhibited by TCDD. We propose that TCDD lowers a regulated level or “set-point” for body weight and that the change in food intake reflects the rat’s effort to reach the new weight level.\nKeywordsFood Intake Reduce Food Intake Total Oxygen Consumption TCDD Treatment Rest Oxygen Consumption\nUnable to display preview. Download preview PDF.", "label": "Yes"}
{"text": "|The process of protein isolation and purification to conduct important procedures in a lab can be very difficult to perform. Usually, specialized chromatography resins are made by attaching a pure protein to the surface of the resin. This protein is then used as bait to bind to the protein that needs to be purified. These conventional processes generally require purification of the protein both before and after labeling, are non-selective either in amino acid site or side-chain chemistry for the protein, and can decrease the ability of the protein to bind and activate its target proteins. There is a critical need for a process to make affinity chromatography resins that can be used to purify proteins with minimal complications.\nResearchers at Purdue University have found a novel method of making affinity chromatography resins for protein purification that is much simpler. By looking at the activity of calcium/calmodulin proteins, researchers found that specific proteins can be tagged with an azide tag and attached to an alkyne substrate immediately from the cell lysate mixture. The advantages of this process are that it simplifies the method by allowing conjugation in a direct manner and purifies a larger quantity of proteins. This would be useful in numerous research laboratories and experimental procedures given its efficiency.\n-Protein specific tagging\n-Direct manner of conjugation\n-Purification of larger amount of proteins\nKulkarni, Chethana, et al. Bioorthogonal Chemoenzymatic Functionalization of Calmodulin for Bioconjugation Applications. Bioconjugate Chemistry. 2015, 26 (10), pp 2153–2160.\nFeb 16, 2016\nFeb 16, 2015\nPurdue Office of Technology Commercialization\n1801 Newman Road\nWest Lafayette, IN 47906\nPhone: (765) 588-3475\nFax: (765) 463-3486", "label": "Yes"}
{"text": "Genomics jobs in United States\nBroaden your search\nRefine your search\nField of specialization\nFound 4 Direct Employer jobs\nWe seek to recruit a highly motivated postdoctoral fellow to the Sczepanski Laboratory at Texas A&M University in the Department of Chemistry.\nTenure Track Faculty Position: Center for Cancer Research and Therapeutic Development at Clark Atlanta University\nThe National Academy of Sciences, Engineering, and Medicine offers postdoctoral and senior research awards\nFellowships in Anticancer Drug Discovery and Regenerative Biology at the Carl R. Woese Institute for Genomic Biology at the University of Illinois.", "label": "Yes"}
{"text": "There’s an estimated number of 1.7 million new cancer cases that are diagnosed each year in the United States alone, with more than 600,000 proving to be fatal. And while many people are now leading healthier and more active lifestyles, basic healthy living protocols such as getting exercise, consuming less fatty foods, avoiding excessive alcohol drinking or quitting smoking are not enough to prevent getting the big C. Cancer, in its many forms, can sneak up on you without you noticing, until they’re spread out over your body. Here are 10 signs and symptoms of cancer that you should not be ignoring:\nIt’s not unusual for you to experience bloating, especially after eating a heavy meal. It’s also normal to go through bloating while you are on your menstrual cycle. But if you’ve been experiencing bloating for several days and it still hasn’t abated, it’s high time to get yourself out of the house and into the hospital for a thorough check up. While it could be some other issue, bloating is a symptom of pancreatic cancer. Pancreatic cancer causes tumors to grow in the abdomen, and when tumors increase in size, they can cause your belly to get distended.", "label": "Yes"}
{"text": "Harakeke and Wharariki\nIn this section\n|Māori names||harakeke, kōrari (Northland)|\n|Other common names||flax, New Zealand flax, swamp flax|\n|Scientific name||Phormium tenax|\n|Family||Hemerocallidaceae (day-lily family)|\nFew New Zealanders would fail to recognise harakeke, one of our most distinctive native plants. It is the principal weaving plant, and many weavers use named forms selected for leaf pliability, colour and fibre quality.\nLeaf strips are used in raranga, the plaiting of kete (containers) and whāriki (mats). Extracted fibre (muka or whītau) is used to make traditional kākahu (cloaks), and for cordage. Today, harakeke is also used in non-traditional ways to create original and exciting works of art.\nHarakeke grows throughout New Zealand, from sea level to about 1300 m in altitude. It is commonly found in lowland wetlands and along rivers, and in coastal areas on estuaries, dunes and cliffs. A hundred years ago, harakeke was much more abundant in many regions, but large wild stands today are diminished and scattered. Harakeke is often seen in gardens, is used widely in landscaping projects and in wetland restoration plantings, and as shelter belts on farmland.\nHarakeke is said to be native also to Norfolk Island, though may have been introduced by Māori. The harakeke found on the subantarctic Campbell and Auckland islands was taken there by Māori and sealers in the 1800s.\nHarakeke is a herbaceous plant, meaning its growth form is soft, not woody. The robust, sword-like leaves are arranged in two adjoining sets around the growing point (rito) to form a fan. A unique feature of harakeke and related plants is that the lower third or so of each leaf is folded together along its midrib or keel. This creates a stiff, heavy butt.\nFans develop from the stout, fleshy underground rhizome or rootstock. The rhizome has many reddish yellow roots of varying lengths that extend laterally or downwards. Hundreds of fans can develop from the rootstock to create the flax bush. Because these offshoots are of the same genetic stock, they exhibit the same leaf and fibre qualities.\nThe number of fans produced in a bush varies a lot and is one of the characteristics that can help identify different weaving cultivars. For instance, the weaving cultivar 'Māeneene' quickly produces many fans set closely together. 'Ngaro', a tall variety with strong fibre, produces fewer, bulkier fans that are set wider apart.\nIn older plants the rootstocks branch, generally away from the centre, and new fans arise that may eventually create a ring around the original plant. Sometimes as the plant ages, the rootstock is exposed above the ground and new fans develop that are less thrifty, through receiving fewer nutrients and moisture. Some strains are more prone to this ‘perching’ behaviour (e.g. the weaving variety 'Paoa').\nMost fans produce about eight mature leaves, four on each side of the rito, before they start to yellow and die off.\nThe look and feel of the leaf is what draws a weaver to consider its worth for raranga or whatu. Harakeke leaves are variable in length (1–4 m), width (2–12 cm), and rigidity. Some bushes have stiff, upright leaves, others are softer and lax. The fibre bundles within the leaf run parallel to the keel. Sometimes these striations show clearly on the surface and the leaf feels rigid and tough. Other leaves are quite smooth to the touch. Leaf colour varies from blue-green, green, yellow-green through to bronze. The leaf underside is often glaucous, with a blue bloom like a plum.\nHarakeke has coloured leaf margins and keel, with orange, red, brown and black being the most common. Colours can vary between young and old leaves, even within a bush. Coloured edges are narrow, thick or smudged. Young leaves in particular are sometimes smudged with colour (particularly reddish brown) at the tips.\nBlack-edged varieties are regarded by some weavers as having the best muka. The well-known varieties 'Kōhunga', 'Taeore' and 'Tapamangu' fall into this category. However, having a black edge and/or keel is not necessarily indicative of good fibre. There are excellent varieties with orange keels and margins, such as 'Arawa' and 'Makaweroa'.\nHarakeke flowers from late October through to February. Each spectacular flower stalk (kōrari) grows up to five metres tall from the centre of the fan, which dies after flowering has taken place. The new kōrari is heavy with sap, but dries out over the summer months and becomes very light.\nEach kōrari has a group of peduncles, like little branches, that grow out from each side of the main stem. These peduncles branch further and carry clusters of dull red flowers.\nEach individual flower has both male and female parts. The copious orange pollen is carried on a thin stalk that sticks up above the flower tepals (the fleshy ‘petals’). The pollen on a particular flower matures before the female parts below are ready to receive it.\nThe flowers are designed to be pollinated by nectar-feeding native birds – tūī, korimako (bellbirds) and pihipihi (waxeyes). Today, starlings, mynahs and honeybees are also frequent visitors.\nWhen a bird visits a flower, it pushes its beak down into the flower tube to feed on the nectar. Pollen brushes onto the top of the bird’s head. The pollen is then transferred to the next receptive flower the bird visits – that is, a flower where the pollen has already been shed, and the stigma and style (female parts) have pushed forward to collect the pollen. The fertile pollen travels down the style to the ovaries at the base. The fertilised ‘eggs’ or ovules then develop into seed, contained in the pod that develops from the flower.\nThe flower bunches on a kōrari do not open all at once. Their opening spreads over about 6 weeks.\nEcologists John Craig and Ann Stewart carried out some experiments on harakeke reproduction and found that harakeke is largely ‘self-incompatible’. Seeds produced from outcrossed flowers (where pollen comes from a different plant) are much more numerous and are larger than those produced by flowers from different kōrari on the same bush. In turn, the latter seeds are larger and more viable than those produced from flowers on the same kōrari. Perhaps compounds exist in the flowers that inhibit the development of plants of the same genetic composition.\nThere are likely to be some changes in genetic composition though, even in the course of vegetative reproduction. For example, leaves of the striking variegated Parekoretawa will, on some fans over time, revert from yellow stripes to green.\nHow often does harakeke flower?\nWe still do not know for sure what triggers harakeke flowering. Bushes do not flower consistently each year, and even in a seemingly prolific year there are regional variations. It was thought that harakeke flowered well about every three years, triggered by high temperatures the previous autumn, but this is not always the case. The cues seem to be more subtle and are not yet well understood.\nFor instance, in the summer of 2007/08, most harakeke in the Orchiston reference collection at Manaaki Whenua, Lincoln, flowered. However, in a nearby trial block of 36 Orchiston cultivars of a similar age, not a single bush flowered. Included in this block are three plants of the cultivar ‘Paoa’, which over many years has been a consistent early flowerer, even in ‘bad’ flowering years.\nThe seed capsules on harakeke form in the summer months, and are upright on the branches. This is the main feature that distinguishes harakeke from wharariki (Phormium cookianum). The pods can be short and stout, or long and narrow, and are triangular in cross section. Each pod contains dozens of black, glistening seeds. When the dry pods burst open, the seed is scattered, and can be carried by water and wind.\nHarakeke is easy to grow from seed, but to ensure a plant has the same properties as the parent bush, it is best to take a fan with some root material attached. Seedlings also take longer to mature, about 6–8 years. Plants grown from root stock take about half that time. See Establishing a Pā Harakeke for detailed information on establishing a pā harakeke – a planting of selected varieties for weaving.\n|Other common names||mountain flax|\n|Scientific name||Phormium cookianum|\n|Family||Hemerocallidaceae (day-lily family)|\nWharariki is found throughout New Zealand, on cliffs and mountain slopes. It is more tolerant of lower temperatures than harakeke. Horticulturalists have developed many coloured ornamental forms that are widely used in gardens and landscaping projects.\nWharariki is generally a smaller plant than harakeke, and the leaves are not as stiff. The leaves are usually less than 2 m in length and inclined to droop. Often there is little or no colour on the margins and keel of wild forms.\nThe leaves are not as stiff because they do not contain such strong fibre bundles. It is more difficult to extract fibre from the leaves of wharariki, and it is weaker and finer. Because the leaves are softer, they are useful for learners. However, they would not make strong kete or whāriki, and with the lack of extractable fibre, wharariki plants are not used for muka.\nFlowers and seeds\nThe flowers are greenish, with tones of orange or yellow (as opposed to the red of harakeke). The most obvious distinguishing feature is the seed pods. The pods of wharariki are long, narrow, and hang down, often with a twist. They curl and become papery with age.\nWharariki tends to flower earlier than harakeke, and more prolifically.\nHarakeke and wharariki are usually found in different environments. The two species can, however, interbreed easily (hybridise). Plant breeders take advantage of this when developing new ornamental strains. Recent molecular work carried out by Rob Smissen and Peter Heenan confirms that there are stable populations of wild hybrids. There may be other species (such as the Chatham Islands flax). Work on the extent of variation in flax species is ongoing.\nSome of the well-known cultivars used by weavers are hybrids, such as 'Mawaru' and 'Wharanui'. Their leaves are light green and relatively soft. The pods have a twist and are not erect like harakeke or as long, curled and papery in old age as wharariki.", "label": "Yes"}
{"text": "No it's not the weather, it's the species. The first issue is identification, Hylocereus and Selenicereus can be difficult to distinguish. The second is the common 'wild' plant that occurs on the east coast is usually referred to as \"Queen of the night\" cactus, this plant flowers but will not produce fruit. That being said it is a great grafting stock:)\nMy Cacti Blog, please come visit me.", "label": "Yes"}
{"text": "Water is much more than we know. Many scientists and leading edge researchers, from around the planet, are continuing to report, that there is much more to know about this ancient substance that supports and sustains our lives.\nThis information is leading us to alter our perceptions, and thereby our relationships and responsibilities to this miraculous and life giving element. What we do know is that we live on a water planet, unique and unlike any other in our Solar System. All of the humans, animals, trees and all life forms that coexist with, come from water, and are made of water. Almost all of the surface of this planet is water. Our bodies are about seventy percent of this life giving substance. There are about 326 trillion gallons of water on planet Earth. Ninety-seven percent of that vast amount is salt water. Only three percent is fresh water and nearly eighty percent of what is fresh, is frozen in the polar ice caps and glaciers around the globe.\nWhat we have left is less than one percent of all of the available water on the planet for people, plants and animals to use, to sustain our lives.\nAs we all live together on this water planet, in our water bodies, we are inherently, and naturally attracted to healthy water. We also know that what were once abundant sources of healthy and alive water are becoming increasingly scarce and, in several scenarios, severely compromised.\nScientists and researchers are continuing to show us that our thoughts affect our own vibrational energy which directly affects the structure of the very water within our bodies and in our environment. It has been proven that water, in it's natural and healthy state of purity and integrity, is intelligent and highly responsive to all other forms of life. It is no longer just theory, that water, like everything else, has consciousness.\nWe believe the following articles will assist you in understanding the importance of this enigmatic substance. These articles contain information pertaining to the many mysterious aspects and faces of water, and water research, including: structured water, clustered water, healthy water, toxic water, dehydration, detoxifying with water, cleansing the lymphatic system with water, water flow forms, water cycles, living water, healthy community water systems, healing water, water remedies, water cures, regeneration with water, health tips, and information on bottled water, water filters, shower filters, tap water and much more. We will be continually making many additions to the Water articles index in the coming weeks and months.\nHealthy Wealth Blogger continues to be deeply involved in researching, developing and publishing information on this very important subject matter. We are working closely with many notable water resources and researchers and will be publishing several exciting and vital articles in the weeks ahead, detailing these findings.\nWe invite you to sit back... relax... and explore at your leisure, choosing your own path through this array of excellent articles. We encourage you to print these articles and enjoy them at your leisure, perhaps finding a grand old tree to sit with as you do. If you would care to share any of these with a friend, please note the option of notifying them by email at the bottom of each page. As always, we welcome your comments. Please remember to bookmark our site, and return often.", "label": "Yes"}
{"text": "100 most important questions in Plant Biology\nA1. How do we feed our children’s children?\nA2. Which crops must be grown and which sacrificed, to feed the billions?\nA3. When and how can we simultaneously deliver increased yields and reduce the environmental impact of agriculture?\nA4. What are the best ways to control invasive species including plants, pests and pathogens?\nA5. Considering two plants obtained for the same trait, one by genetic modification and one by traditional plant breeding techniques, are there differences between those two plants that justify special regulation?\nA6. How can plants contribute to solving the energy crisis and ameliorating global warming?\nA7. How do plants contribute to the ecosystem services upon which humanity depends?\nA8. What new scientific approaches will be central to plant biology in the 21st Century?\nA9. (a) How do we ensure that society appreciates the full importance of plants?\nA9. (b) How can we attract the best young minds to plant science so that they can address Grand Challenges facing humanity such as climate change, food security, and fossil fuel replacement?\nA10. How do we ensure that sound science informs policy decisions?\nA11. How can we translate our knowledge of plant science into food security?\nA12. Which plants have the greatest potential for use as biofuels with the least effects on biodiversity, carbon footprints and food security?\nA13. Can crop production move away from being dependent on oil-based technologies?\nA14. How can we use plant science to prevent malnutrition?\nA15. How can we use knowledge of plants and their properties to improve human health?\nA16. How do plants and plant communities (morphology, colour, fragrance, sound, taste etc.) affect human well-being?\nA17. How can we use plants and plant science to improve the urban environment?\nA18. How do we encourage and enable the interdisciplinary that is necessary to achieve the UN’s Millennium Development Goals, which address poverty and the environment?\nB1. How can we test if a trait is adaptive?\nB2. What is the role of epigenetic processes in modulating response to the environment during the life span of an individual?\nB3. Are there untapped potential benefits to developing perennial forms of currently annual crops?\nB4. Can we generate a step-change in C3 crop yield through incorporation of a C4 or intermediate C3 ⁄C4 or crassulacean acid metabolism (CAM) mechanism?\nB5. How do plants regulate the proportions of storage reserves laid down in various plant parts?\nB6. What is the theoretical limit of productivity of crops and what are the major factors preventing this being realized?\nB7. What determines seed longevity and dormancy?\nB8. How can we control flowering time?\nB9. How do signalling and cross-talk between the different plant hormones operate?\nB10. Can we develop salt ⁄ heavy metal ⁄ drought-tolerant crops without creating invasive plants?\nB11. Can plants be better utilized for large-scale remediation and reclamation efforts on degraded and ⁄ or toxic land?\nB12. How can we translate our knowledge of plants and ecosystems into ‘clever farming’ practices?\nB13. Can alternatives to monoculture be found without compromising yields?\nB14. Can plants be bred to overcome dry land salinity or even reverse it?\nB15. Can we develop crops that are more resilient to climate fluctuation without yield loss?\nB16. Can we understand (explain and predict) the succession of plant species in any habitat, and crop varieties in any location, under climate change?\nB17. To what extent are the stress responses of cultivated plants appropriate for current and future environments?\nB18. Are endogenous plant adaption mechanisms enough to keep up with the pace of man-made environmental change?\nB19. How can we improve our cultivated plants to make better use of finite resources?\nB20. How do we grow plants in marginal environments without encouraging invasiveness?\nB21. How can we use the growing of crops to limit deserts spreading?\nC1. What are the best ways to control invasive species including plants, pests and pathogens?\nC2. Can we provide a solution to intractable plant pest problems in order to meet increasingly stringent pesticide restrictions?\nC3. Is it desirable to eliminate all pests and diseases in cultivated plants?\nC4. What is the most sustainable way to control weeds?\nC5. How can we simultaneously eradicate hunger and conserve biodiversity?\nC6. How can we move nitrogen-fixing symbioses into non-legumes?\nC7. Why is symbiotic nitrogen fixation restricted to relatively few plant species?\nC8. How can the association of plants and mycorrhizal fungi be improved or extended towards better plant and ecosystem health?\nC9. How do plants communicate with each other?\nC10. How can we use our knowledge of the molecular biology of disease resistance to develop novel approaches to disease control?\nC11. What are the mechanisms for systemic acquired resistance to pathogens?\nC12. When a plant resists a pathogen, what stops the pathogen growing?\nC13. How do pathogens overcome plant disease resistance, and is it inevitable?\nC14. What are the molecular mechanisms for uptake and transport of nutrients?\nC15. Can we use nonhost resistance to deliver more durable resistance in plants?\nD1. How do plant cells maintain totipotency and how can we use this knowledge to improve tissue culture and regeneration?\nD2. How are growth and division of individual cells coordinated to form genetically programmed structures with specific shapes, sizes and compositions?\nD3. How do different genomes in the plant talk to one another to maintain the appropriate complement of organelles?\nD4. How and why did multicellularity evolve in plants?\nD5. How can we improve our understanding of programmed developmental gene regulation from a genome sequence?\nD6. How do plants integrate multiple environmental signals and respond?\nD7. How do plants store information on past environmental and developmental events?\nD8. To what extent do epigenetic changes affect heritable characteristics of plants?\nD9. Why are there millions of short RNAs in plants and what do they do?\nD10. What is the array of plant protein structures?\nD11. How do plant cells detect their location in the organism and develop accordingly?\nD12. How do plant cells restrict signalling and response to specific regions of the cell?\nD13. Is there a cell wall integrity surveillance system in plants?\nD14. How are plant cell walls assembled, and how are their strength and composition determined?\nD15. Can we usefully implant new synthetic biological modules in plants?\nD16. To what extent can plant biology become predictive?\nD17. What is the molecular ⁄ biochemical basis of heterosis?\nD18. How do we achieve high-frequency targeted homologous recombination in plants?\nD19. What factors control the frequency and distribution of genetic crossovers during meiosis?\nD20. How can we use our knowledge about photosynthesis and its optimization to better harness the energy of the sun?\nD21. Can we improve algae to better capture CO2 and produce higher yields of oil or hydrogen for fuel?\nD22. How can we use our knowledge of carbon fixation at the biochemical, physiological and ecological levels to address the rising concentrations of atmospheric CO2?\nD23. What is the function of the phenomenal breadth of secondary metabolites?\nD24. How can we use plants as the chemical factories of the future?\nD25. How do we translate our knowledge of plant cell walls to produce food, fuel and fibre more efficiently and sustainably?\nE14. What is the answer to Darwin’s ‘abominable mystery’ of the rapid rise and diversification of angiosperms?\nE15. How has polyploidy contributed to the evolutionary success of flowering plants?\nE16. What are the closest fossil relatives of the flowering plants?\nE17. How do we best conserve phylogenetic diversity in order to maintain evolutionary potential?\nHave a look at these question - which ones interest you? It might help you decide how to pick a university degree or dissertation/thesis topic!\nHumans and plants\nPlant adaptation and agriculture\nPlant pathogens, fungi and nutrient transportation\nMolecular biology, epigenetics and photosynthesis\nBiodiversity, speciation and evolution\nE1. How much do we know about plant diversity?\nE2. How can we better exploit a more complete understanding of plant diversity?\nE3. Can we increase crop productivity without harming biodiversity?\nE4. Can we define objective criteria to determine when and where intensive or extensive farming practices are appropriate?\nE5. How do plants contribute to ecosystem services?\nE6. How can we ensure the long-term availability of genetic diversity within socio-economically valuable gene pools?\nE7. How do specific genetic differences result in the diverse phenotypes of different plant species? That is, why is an oak tree an oak tree and a wheat plant a wheat plant?\nE8. Which genomes should we sequence and how can we best extract meaning from the sequences?\nE9. What is the significance of variation in genome size?\nE10. What is the molecular and cellular basis of plants’ longevity and can plant life spans be manipulated?\nE11. Why is the range of life spans in the plant kingdom so much greater than in animals?\nE12. What is a plant species?\nE13. Why are some clades of plants more species-rich than others?", "label": "Yes"}
{"text": "Tanacetum parthenium, known as feverfew or bachelor's buttons, is a flowering plant in the daisy family Asteraceae. It is a traditional medicinal herb which is commonly used to prevent migraine headaches.\nFeverfew can also help to promote blood vessel tone, support healthy digestive and kidney function, relieve menstrual cramps and boost respiratory health.\nSuitable for Vegans/Vegetarians\nEthically sourced from the very best suppliers worldwide\nAn easy way to supplement your diet", "label": "Yes"}
{"text": "What symptoms did you experience with cervical cancer?\nShare your story with others:\nMedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.\nWhat are the symptoms and signs of cervical cancer?\nCervical cancer may not produce any symptoms or signs. In particular, early stage cervical cancers, like precancerous changes, typically do not produce symptoms. Symptoms may develop when the cervical cancer cells start to invade surrounding tissues.\nSymptoms and signs of cervical cancer include:\nAbnormal vaginal bleeding\nVaginal bleeding after menopause\nVaginal bleeding after sex\nBleeding or spotting between periods\nLonger or heavier menstrual periods than usual\nOther abnormal vaginal discharge\nPain during sexual intercourse\nIt is important to note that these symptoms are not specific for cervical cancer and can be caused by a variety of conditions.", "label": "Yes"}
{"text": "The process of polar auxin transport, central to a plant's auxin relations, can be inhibited by a group of synthetic compounds that apparently act by binding to a plasma membrane protein known as the naphthylphthalamic acid (NPA) receptor. No endogenous ligand to the NPA receptor, capable of affecting polar auxin transport in plants, has yet been found. It is now shown that a group of flavonoids - including quercetin, apigenin, and kaempferol - can specifically compete with [3H]NPA for binding to its receptor and can perturb auxin transport in a variety of plant tissues and transport systems in a manner closely paralleling the action of synthetic transport inhibitors. Because the active flavonoids are widely distributed in the plant kingdom and exert their effects at micromolar concentrations approximating likely endogenous levels, they may act as natural auxin transport regulators in plants.\n|Original language||English (US)|\n|Number of pages||4|\n|State||Published - 1988|\nASJC Scopus subject areas", "label": "Yes"}
{"text": "Oil pastel on paper by Beverley Dancy. Worm lettering and border by Andrea Choe.\nView the full size version.\nOil pastel on paper by Beverley Dancy. Worm lettering and border by Andrea Choe.\nView the full size version.\nN1 still disgruntled over Brenner’s choice (Cambridge UK). Disproving the popular maxim that time heals all wounds, N1 made clear in a statement today that it is every bit as annoyed about not becoming the “chosen strain” as it was nearly 50 years ago. “Bristol had nothing on me then and it’s got nothing on me now,” said the visibly petulant Caenorhabditis elegans isolate obtained from Sidney Brenner’s backyard. “Mushroom compost? Give me a break,” added the derisive strain, referring to the humble origins of N2. According to N1, “It was totally political from the very beginning. These things always are. Anyway, it’s not like I really wanted to be prodded, mutagenized, starved, bleached and ultimately autoclaved by a bunch of sadistic scientists,” the transparently begrudging nematode added. “So the joke’s on you, N2. Hope you’ve enjoyed the last 50 years, because you’ve got a lot more of the same coming.”\nProject dies peaceful death surrounded by loved ones (University of Davis, CA). Following a prolonged, uphill and often painful battle, NIH proposal GM052937 is finally at rest according to sources close to the proposal. Whereas the termination of the project came as something of a shock to its long-term collaborators, those closest to the revised R01 had expressed serious concerns in the months leading up to its death. “The signs were all there,” said one of the postdocs intimately familiar with the well-being of the project. “Insufficient preliminary data, a delay in publications, and a lack of connectivity to the aims. It was clear enough if you just looked.” The proposal’s brave but futile struggle was accompanied by emotions typical of end-of-project scenarios including a denial of experimental flaws, anger at reviewers and funding agencies, bargaining with editors, depression of summer salaries, and ultimately acceptance into a journal of significantly lower impact than was expected. Still, in all endings new beginnings may find their genesis. “It’s hard to know what lies beyond the mythical ‘great wall’,” stated one of the lead investigators after learning of the project’s demise. “Perhaps there’s nothing whatsoever. But maybe the Hindus have it right, and reincarnation awaits all things that pass.” As of press time, the project’s PIs were rumored to be heavily favoring the “theory of rebirth” in the form of an R21.\nWorm theologians ponder meaning of ‘Pick of Fate’ (Petri dish). Ancient mythological narratives within the C. elegans community have long included fanciful tales of shining objects that descend from the sky, arbitrarily removing “chosen members” of the population. “Though it’s considered an ill omen to speak of, the Pick Gods must be appeased once in every generation,” proclaimed one worm elder, who spoke on condition of anonymity. Although reasons for the apparent sacrifices continue to elude the nematode clerics, it has been noted that virgin L4s appear to “please the giant gleaming spade” above all others. Some survivors of the choosing ceremony have reported approaching a bright light or flame. Still others claim that it is a form of alien abduction in which individuals are subjected to painful gonadal probing by a giant clear needle. Such survivors have described recovering consciousness on a completely different plate while smeared from nose to tail in a kind of viscous oily substance, possibly of an inter-dimensional or protoplasmic nature. Conspiracy theorists within the worm community have gone so far as to suggest that these individuals may have been “implanted” with a “seed of foreign origin”, although this theory remains controversial. Nevertheless, universal agreement behind the meaning of “Shovel Selection” is likely to remain unresolved. Stated one wizened post-gravid hermaphrodite, “We can only hope that a divine and loving intelligence is controlling the pick and that it does not merely represent the whims of some dispassionate cosmic manipulator.”\nThe C. elegans Development, Cell Biology & Gene Expression meeting is in Nara, Japan this July15th-19th, 2014. This meeting is in association with the 6th Asia-Pacific C. elegans Meeting.\nMeeting Website: http://cedevap2014.sakura.ne.jp/\nAbstract and registration opened March 9, 2014. Please pay attention to the deadlines.\nEarly registration: May 9\nLate registration: June 30\n**On and after May 10, registration fee will be higher\nAbstract Deadline: May 9\nFinancial Aid: We have received several grants to cover travel expenses of presenters (posters or talks). Please apply for this financial aid if needed.\nHotels: You must make your own hotel reservations by June 30th.\nHope to see you there!\nAhna Skop, Asako Sugimoto & Andrew Chisholm, Head Organizers\nOur lab has previously developed a combination of single-step SNP mapping and whole genome sequencing (WGS) methods to pinpoint phenotype-causing sequence variants (Doitsidou et al., 2010). The mapping part of the single-step procedure is essential to separate the phenotype-causing, mutagen-induced sequence variant from background sequence variants. WGS data can be analyzed with CloudMap, a free, cloud-based software analysis tool that we recently developed (Minevich et al., 2012). We have previously provided proof-of-concept studies for the use of CloudMap, and we report here our experience with using CloudMap on a routine basis.\nWe have found over the last two years that the SNP/WGS strategy and ensuing CloudMap-based data analysis can reproducibly and accurately pinpoint phenotype-causing mutations to mapping regions as small as 0.5 Mb and that the method can work with very few recombinants. Fig. 1 shows the mapping plots from a selection of 16 EMS mutagenized strains from 8 different EMS-induced screens for loss of neuronal identity (thanks to many members of the Hobert lab for providing the mapping data). The tallest histograms indicate the regions containing the largest amount of normalized pure parental alleles following an outcross to the Hawaiian CB4856 mapping strain. For 14 of the causal variants in 13 strains (ot628 is a confirmed double mutant) we have either cloned the causal variant or have strong evidence for its identity and are in the process of confirming. For 8/14 of the causal variants, CloudMap correctly identified the 0.5 Mb where the causal variant resides. In the 6 cases where the 0.5 Mb bins did not correctly identify the causal variant, CloudMap was off by an average of 0.54 Mb.\nThe accuracy of CloudMap in identifying mapping intervals depends on strict adherence to the Hawaiian SNP mapping protocol and also on the number of F2 recombinants that are pooled for sequencing. In addition, Mendelian ratios should be calculated to identify whether the causal variant resides at one locus or many and if it is dominant or recessive. We also recommend thawing an ancestral Hawaiian strain once a year to minimize variants introduced by genetic drift and to maximize mapping accuracy.\nIn a number of cases where the Hawaiian mapping protocol was strictly followed, CloudMap was able to identify the correct 0.5 Mb mapping interval with very few recombinants. For example, both hu80 and hu97 were correctly mapped to a 0.5 Mb mapping interval with as few as 16 and 34 F2 recombinants respectively.\nWe consistently noted that the previously described incompatibility region between Bristol and Hawaian strains on the left arm of LG I (Seidel et al., 2008) is largely not visible relative to the peak of the causal variant due to the normalization procedure we use to compute the frequency of pure parental alleles. In cases where the causal variant is also on LG I (ot740, the taller peak contains the causal variant), CloudMap was able to separate the incompatibility peak from the causal variant peak.\nTransgenes contained in the strain background and required to observe a mutant phenotype can generate a mapping signal if the transgene is re-homozygosed in the F2 generation. We find that this mapping signal is virtually eliminated if as few as 50% of the picked F2 recombinants are heterozygous for the transgene.\nCloudMap is available via the Galaxy web platform, requires no installation when run on the cloud, and can also be run locally or via the Amazon Elastic Compute Cloud (EC2) service (http://usegalaxy.org/cloudmap and http://hobertlab.org/cloudmap).\nMutation mapping by whole-genome sequencing (WGS) is becoming increasingly popular with C. elegans researchers. Pioneering studies from several worm labs have laid the foundations for this trend by providing proofs of concept (Sarin et al., 2008; Flibotte et al., 2010), working out experimental strategies (Doitsidou et al., 2010, Zuryn et al., 2010), and contributing tools and workflows for the analysis of mapping-by-sequencing data (Minevich et al., 2012).\nYet even though many good bioinformatic tools for WGS data analysis exist, almost all of them seem daunting to biologists. The CloudMap collection of workflows and tools for Galaxy is a notable exception here, but it requires the upload of huge experimental datasets to the main Galaxy server (http://usegalaxy.org), which is time-consuming and not well-suited for maintaining an archive of data from several experiments. Hence, most people in the field still do not consider analyzing WGS data themselves, and the resulting need to establish collaborations prevents a more rapid spread of mapping-by-sequencing approaches in the community.\nWe have recently developed MiModD, a comprehensive software package for the identification and annotation of mutations in the genomes of model organisms from whole-genome sequencing data, with the specific goal to enable biologists/geneticists with limited bioinformatical knowledge to analyze genome-wide sequencing data locally on (relatively) standard desktop computers. The current beta version of MiModD enables short-reads alignment from several input formats, variant calling, post-processing (i.e., filtering and annotating lists of variants), and the generation of summary reports with hyperlinks to biological databases including Wormbase. It also supports various mapping-by-sequencing approaches by producing CloudMap-ready output, i.e., variant lists produced by MiModD can be used directly with the CloudMap EMS Variant Density, Variant Discovery Mapping, and Hawaiian Variant Mapping tools. By default, the package is controlled through a command line interface, but can be fully integrated, with a single command, into a local installation of Galaxy to obtain a beginner-friendly graphical user interface and a lab-internal WGS analysis server.\nIn principle, MiModD can be used to analyze WGS data from any organism, but its memory requirements are dependent on genome size. To analyze C. elegans data we recommend a system with 16GB of memory (though 8GB will do for testing). The package runs on Linux and Mac OS systems without any further strict hardware requirements. Obviously, performance will depend on the exact configuration of the system MiModD is running on, but on our development machine – a desktop PC equipped with a 3rd generation Intel Core i7 processor, 16 GB RAM and an Ubuntu 12.04 operating system – the complete analysis of a 30x covered worm genome finishes in less than 1 hour, which should be good enough for the occasional user.\nMiModD is free, open-source and actively developed, and labs interested in WGS analysis are encouraged to download and test the software. We offer assistance with installing and using the package to users of the beta version and are looking forward to receiving your feedback. Further information is available at www.celegans.de/mimodd.\nFlibotte S, Edgley ML, Chaudhry I, Taylor J, Neil SE, Rogula A, Zapf R, Hirst M, Butterfield Y, Jones SJ, et al. (2010). Whole-genome profiling of mutagenesis in Caenorhabditis elegans. Genetics 185, 431-441.", "label": "Yes"}
{"text": "Why Your Meals Should Contain Calcium\nHave you ever wondered why your teeth suddenly break on their own? Have you once in a while felt like your bones are as feeble as that of a nonagenarian even while you are as young as 25? Have you knowingly or unknowingly been excluding calcium from your meals? Are you among those who think calcium is an insignificant nutrient, and if it is not included in your diet, there would be no problems at all? Do your pedicurist and manicurist sly you as a result of your brittle, ugly looking nails each time you book an appointment? The cause of your funny ‘nonagenarian feeling’ and sudden break of teeth, as well as feeble and weak bones, teeth, and nails, are pointers to the deficiency of calcium in your body. This could be really dangerous to your health, as it could land you in places you least expect.\nWhy You Need Calcium\nYou do not want to begin to complain of waist pain at the age of 35. You do not want to have severe bone fractures upon any little fall you have. You do not want to lose all your teeth at 35 while making a dentist a do-or-die friend in your life. You also do not want to use artificial teeth, knowing fully well that the reason for your massive loss of teeth is your fault.\nIf you seek reasons why calcium is essential to your wellbeing, you have come to the right place. This article has within it the health benefits of calcium, causes of calcium deficiency, the symptoms of calcium deficiency, and the major topic of the article, which is the risks you expose yourself to when you refuse to include calcium in your diet. However, before we begin, the most explicit definition of calcium deficiency is the extreme lack of calcium in the body. Got that?\nHealth Benefits of Calcium\nLet me present the benefits of the nutrients you treat as insignificant. Most people lack this nutrient so much that it becomes a big deal in their bid to restore it into their bodies; at this point, its status changes from insignificant to ‘quintessential.’\n- Calcium is well known for its function for the development, growth, and strengthening of the teeth.\n- It also aids in making the bones stronger.\n- It helps the heart function properly.\n- It ensures that the muscles stay strong and healthy and prevents muscle contraction.\n- Calcium and Vitamin D combined help protect your body against cancer, diabetes, and high blood pressure.\n- The record holds that calcium sees to the efficient functioning of some key enzymes.\n- Calcium also helps generate blood clotting and ensures that the blood vessels work perfectly.\n- It helps nerves pass the right messages to the brain.\n- Generally, calcium generates strength for the whole body.\n- Your body does not produce calcium. You can only get calcium from meals, and having appropriate amounts of calcium in your body would help keep you away from your Doctor (except the Doctor is a close friend.)\nSources of Calcium\nCalcium can be found in foods, and some of these foods include;\n- Soy products with added calcium\n- Bread and other fortified flour products\n- Bony fishes\n- Broccoli, spinach, and other green leafy vegetables\n- Beans and lentils also contain decent amounts of calcium\n- Fortified drinks\nQuickly note that;\n- The medical record holds that people who eat the bones of fishes and other meats tend to grow healthy teeth, nails and bones as these animal bones they eat contain high levels of calcium that are sufficient for the body.\nCauses of Calcium Deficiency\n- The primary and most apparent cause of calcium deficiency is the lack of calcium intake for a long time, this has to do with the absence of the inclusion of calcium in diets. It happens mainly when you do not eat calcium-giving foods.\n- Also, another reason found to be the cause of calcium deficiency is Vitamin D deficiency. Vitamin D ensures the absorption of calcium, so no matter how much calcium content you have if you lack Vitamin D to absorb it, you would suffer from the health risks attached to calcium deficiency. This automatically means that the idea of calcium in the body depends on an existing and functioning Vitamin D; without this, there would be no calcium content in your body.\nOther Causes Include;\n- Medications: Some medications are used repeatedly, tamper with the calcium content in your body. One of these medications is chemotherapy medications. They do this by affecting the Vitamin D content, which eventually makes it impossible to absorb calcium.\n- Hormonal changes also cause calcium deficiency. This is very common with the womenfolk.\n- Another cause of calcium deficiency could also be genetic factors.\n- Excessive consumption of magnesium can also lead to calcium deficiency as it alters the proper absorption and functioning of calcium.\n- The record holds that excessive sodium and protein intake would cause calcium excretion, thereby making your body lose calcium.\n- Some digestive diseases have also been found to cause calcium deficiency.\n- Body activities that eliminate calcium through sweat or urine can also cause calcium deficiency.\n- High coffee and alcohol consumption.\n- Kidney and thyroid diseases.\n- Age is also a factor. Wondering how this is possible? Infants are known to absorb 60% of the calcium they get in foods; however, as they grow, the absorption level reduces to about 20%\nEffects of Calcium Deficiency\n- Constant muscle cramps, contraction, and spasm\n- Excess and continuous fatigue and sluggishness\n- Dry skin, skin irritation, and skin infections like eczema\n- Osteopenia; the reduction of the mineral density in the bone\n- Osteoporosis; this makes the bones thinner. Both osteopenia and osteoporosis cause severe pain and acute disability as well as bad posture\n- Rickets in children\n- Extremely painful menstruation\n- Weak bones, nails, and muscles\n- Heart diseases\n- Some forms of cancer\n- Severe dental issues\n- Poor blood clotting\n- Delayed growth and development in children\n- Heart-related illnesses\nThese are the health risks of the lack of calcium in the body. Little or no amounts of calcium in the body would lead to any of the following health issues mentioned above. This automatically means that one way to keep a healthy medical record lies in supplying your body with necessary nutrients like calcium.\nSymptoms of Calcium Deficiency\n- Memory loss which is closely linked with confusion\n- Numbness in the face, feet, and hands\n- Weak nails\n- Constant muscle cramps\n- Easy fracture of bones\n- Easy breakage of teeth\n- Extreme and continuous fatigue and fainting\n- Itchy and dry skin which can lead to eczema\n- Brittle nails\n- Extremely painful menstruation\n- Difficulty swallowing\nThe excellent news about calcium deficiency is that its treatment process is not complicated. It has to do with changes in lifestyle and diet and dedication to the treatment routine. With all of these in place, the lost calcium in your body would return, and you would see yourself strong and healthy again.\nHow Do You Treat It?\n- To begin with, change your diet. Make sure your diet includes calcium-giving foods like dairy products, soy products, beans, fish bones, fortified bread, green leafy vegetables, and so on. All of these are have calcium contents in them.\n- Furthermore, after you must have started out with your calcium diet, make sure that every physical activity you engage in does not make you lose excess calcium through sweat or urine.\n- Avoid excessive intake of magnesium, sodium, protein, and phosphate.\n- Eat foods that contain Vitamin D, as Vitamin D is a key factor in the absorption of calcium into your body.\n- Then eat more and more meals that contain calcium and Vitamin D. Also, do not forget to chew biscuit bones as they contain calcium as well.\nNow that you know that calcium is not so insignificant after all, would you still ignore it? Ignoring it would be extremely detrimental to your health. Remember that calcium is not part of your body’s makeup. To supply your body with calcium, you have to eat calcium-giving foods and foods rich in Vitamin D, which would also help your body absorb calcium. These foods include dairy and soy products, fortified flour products, bones, and many more. The illnesses associated with calcium deficiency is not favorable; however, its treatment process is relatively easy and more advantageous than its symptoms and effects. Your health is a very important part of you, hence the need to take care of it by protecting it from deficiencies as little as calcium deficiency.", "label": "Yes"}
{"text": "Turtles feed predominantly on plants. However, animal proteins in the form of insects and fish should also be regularly on the menu. With a one-sided and unbalanced diet, the animals are quickly prone to deficiency symptoms. These are often noticeable in the form of shell deformation or can lead to organ damage. Turtle feed should therefore contain an appropriate mixture of plants and animal proteins. In addition, you can equip the terrarium with water lettuce or floating aquatic plants. Even though they are so unassuming, turtles are also good hunters. In addition to turtle feed, there are also a few water fleas, amphipods or mosquito larvae that you can place in the terrarium.", "label": "Yes"}
{"text": "Title: Studies on prevalence of gastrointestinal helminthic infections and their associated risk factors in dairy animals of semi-arid eastern plains of Rajasthan\nAuthors: Monika, Abhishek Gupta, PK Pilania, N Kumar, KP Parmar and GS Manohar\nSource: Ruminant Science (2017)-6(1):55-62.\nCite this reference as: Monika, Gupta Abhishek, Pilania PK, Kumar N, Parmar KP and Manohar GS (2017).Studies on prevalence of gastrointestinal helminthic infections and their associated risk factors in dairy animals of semi-arid eastern plains of Rajasthan. Ruminant Science 6(1):55-62.\nA total of 649 faecal samples comprising of 392 samples from cattle (215; native and 177; crossbred) and 257 from buffaloes were collected randomly from dairy animals of semi-arid eastern plains of Rajasthan during summer, rainy and winter seasons from March 2016 to January 2017. Coprological examination of samples revealed an overall prevalence of 55.62% for gastrointestinal helminthic (GIH) infections. Among various helminthes, highest prevalence reported was of strongyles (55.01%), followed by amphistomes (14.02%), Strongyloides sp. (12.48%), Trichuris sp. (10.01%), Moniezia sp. (1.38%) and Fasciola sp. (1.08%) in the decreasing order of prevalence. Quantitative analysis revealed mild to high severity of infections in terms of EPG with strongyles, Strongyloides sp. amphistome and Moniezia sp. ranging from 200-5500, 100-1700, 100-700 and 200-3400 with an average of 1218.92±249.37, 700±205.17, 244.44±66.90 and 1300±1051.64 eggs per gram, respectively. Statistical analysis using multivariate binary logistic regression model revealed highly significant difference (P<0.01) in the prevalence of GIH infection in the different types of dairy animals, among different seasons from different districts of the study area. Coprolculture analysis revealed the presence of larvae of genera Haemonchus, Oesophagostomum, Trichostrongylus, Bunostomum, Strongyloides, Cooperia and Nematodirus in the decreasing order of prevalence in the dairy animals of semi-arid eastern plain zone of Rajasthan.\nAkanda MR, Hasan MMI, Belal SA, Roy AC, Ahmad SU, Das R and Masud AA (2014). A survey on prevalence of gastrointestinal parasitic infection in cattle of Sylhet division in Bangladesh. American Journal of Phytomedicine and Clinical Therapeutics 2:855-860.\nAnonymous (1990). Self-medication of ruminants. Animal Disease Research Laboratory, NDDB, Anand. Annual report. pp 19-21.\nAsif Raza M, Ayaz MM, Murtaza S and Akhtar MS (2013). Prevalence of GIT Helminths in cattle at the vicinities of tehsil Jatoi, Punjab. Pakistan. Science International 25:305-309.\nBushra M, Shahardar RA and Maria A (2013). Prevalence of gastrointestinal helminth parasites of cattle in central zone of Kashmir valley. Journal of Veterinary Parasitology 27:33-36.\nChandravathi T and Kiran KB (2015). Gastrointestinal parasitism in large ruminants of Khammam district, Telangana state. Indian Journal of Veterinary Sciences and Biotechnology 10:22-24.\nChaudhri SS, Bisla RS, Bhanot V and Singh H (2014). Prevalence of helminthic infections in diarrhoeic cows and buffaloes of eastern Haryana. Indian Journal of Animal Research 48:55-58.\nChoubisa SL and Jaroli VJ (2013). Gastrointestinal parasitic infection in diverse species of domestic ruminants inhabiting tribal rural areas of southern Rajasthan, India. Journal of Parasitic Disease 37:271-275.\nCopeman D and Copland R (2008). Importance and potential impact of liver fluke in cattle and buffalo. In: Overcoming Liver Fluke as a Constraint to Ruminant Production in South-East Asia, ACIAR Monograph-133. Canberra, Australia. pp 21-25.\nDurie PH (1961). Parasitic gastroenteritis of cattle: The distribution and survival of infective strongyle larvae on pasture. Australian Journal of Agricultural Research 12:1200-1211\nGodara R and Manohar GS (2004). Prevalence of gastrointestinal parasitism in different breeds of cattle of Rajasthan. Indian Veterinary Medical Journal 28:74.\nGodara R and Sharma RL (2010). Parasitic infections in livestock at Jaipur. Journal of Veterinary Parasitology 24:193-195.\nGupta A, Dixit AK, Dixit P and Mahajan C (2012). Prevalence of gastrointestinal parasite in cattle and buffaloes in and around Jabalpur, Madhya Pradesh. Journal of Veterinary Parasitology 26:186-188\nGupta SK and Singla LD (2012) Diagnostic trends in parasitic diseases of animals. In: Veterinary Diagnostics: Current Trends. Eds: RP Gupta, SR Garg, V Nehra and D Lather. Satish Serial Publishing House, Delhi, pp 81-112.\nHaque M, Jyoti, Singh NK, Juyal PD, Singh H, Singh R and Rath SS (2011). Incidence of gastrointestinal parasites in dairy animals of western plains of Punjab. Journal of Veterinary Parasitology 25:168-170.\nJithendran KP and Bhat TK (1999). Epidemiology of parasitoses in dairy animals in the North- west humid Himalayan region of India with particular reference to gastrointestinal nematodes. Tropical Animal Health Production 31:205-214.\nMage C, Bourgne, H, Toullieu J M, Rondelaud D and Dreyfuss G (2002). Fasciola hepatica and Paramphistomum daubneyi: Changes in prevalences of natural infections in cattle and in Lymnaea truncatula from Central France over the past 12 years. Veterinary Research 33:439-447.\nMuraleedharan S (2005). Prevalence of gastrointestinal parasites of livestock in a central dry zone of Karnataka. Journal of Veterinary Parasitology 19:31-33.\nRenwal KK, Gupta A, Kumar N, Pilania PK and Manohar GS (2016). Prevalence and risk assessment of gastrointestinal helminthoses in dairy animals of Bikaner, Rajasthan. Journal Parasitic Disease doi:10.1007/s12639-016-0850-x\nRowe AK, McMaster K, Emery D and Sangster N (2008). Haemonchus contortus infection in sheep: Parasite fecundity correlates with worm size and host lymphocyte counts. Veterinary Parasitology 153:285-293.\nRoy S, Tiwari A, Galdhar CN, Upadhyay SR and Ratre HK (2004). Prevalence of parasitic infection in stall fed and grazing bovines of Chhattisgarh. Indian Veterinary Journal 81:345-347.\nSaravanan S, Dinakaran AM, Muralidharan J, Geetha M and Selvaraju G (2009). Prevalence of subclinical gastrointestinal parasitic infection in dairy animals. Indian Journal of Field Veterinarians 5:45-46.\nSingh A, Gangwar AK, Shinde NK and Srivastava S (2008). Gastrointestinal parasitism in bovines of Faizabad. Journal of Veterinary Parasitology 22:31-33.\nSingh AP, Singla LD and Singh A (2000) A study on the effects of macroclimatic factors on the seasonal population dynamics of Boophilus micropus (Canes, 1888) infesting the cross-bred cattle of Ludhiana district. International Journal of Animal Science 15(1): 29-31.\nSloss MW, Kemp RL and Zajac AM (1994). Veterinary Clinical Parasitology. 6th Edn, International Book Distributing Co. pp 3-88.\nSingh ST, Malhotra P and Singla LD (2014). Fatal natural infection with microfilariae of Setaria species in a cattle bull. Progress Research 9(1): 355-356.\nSquire SA, Amafu-Dey H and Beyuo J (2013). Epidemiology of gastrointestinal parasites of cattle from selected locations in Southern Ghana. Livestock Research for Rural Development 25:117.\nSwarnakar G, Bhardawaj B, Sanger B and Roat K (2015). Prevalence of gastrointestinal parasites in cow and buffalo of Udaipur district, India. International Journal of Current Microbiology and Applied Science 4:897-902.\nVanwyk JA and Mayhew E (2013). Morphological identification of parasitic nematode infective larvae of small ruminants and cattle: A practical lab guide. Onderstepoort Journal of Veterinary Research 80:539.\nWaruiru RM, Kyvsgaard NC, Thamsborg SM, Nansen P, Bogh HO, Munyua WK and Gathuma JM (2000). The prevalence and intensity of helminth and coccidial infections in dairy cattle in central Kenya. Veterinary Research Communications 24:39-53.", "label": "Yes"}
{"text": "A Child's Life\nVolume 25 Number 2\nOra Hirsch Pescovitz\nPhoto by Office of Visual Media, IU School of Medicine\nNot Just an Apple a Day\nWhen it comes to 21st-century pediatric problems, there are few researchers moreinvolved or thoughtful than Ora Hirsch Pescovitz, executive associate dean for research affairs at the Indiana University School of Medicine. Also director of pediatric endocrinology and diabetology and the Edwin Letzter Professor of Pediatrics, Pescovitz is both clinical and basic investigatorshe has published in 150 scientific publications and has served as president of the Society for Pediatric Research, the world's largest pediatric research organization.\nPausing between dean's office meetings, hospital visits, and time on the lab bench, Pescovitz offered her expert take on the causes and consequences of some of thorniest issues affecting childhood health: widespread diabetes, puberty as early as 6 or 7, and growth hormone use.\nSince Pescovitz began concentrating on this area 20 years ago, researchers have learned a tremendous amount about growth hormone and achieved major advances in understanding the genetic causes of growth disorders. Prior to 1985, the only way doctors could get their hands on growth hormone involved harvesting human cadavers.\n\"That obviously restricted the availability,\" Pescovitz says. \"And in fact there were some significant complications associated with its use, which is why it was withdrawn.\" Some children whose families resorted to this treatment died of a serious neurological disorder closely related to Mad Cow disease. Growth hormone extracted from cadavers was later replaced by genetically engineered versions.\nOf course, children with growth disorders don't always respond to growth hormone treatments. \"There are still a number of situations where we don't understand why children do not grow,\" says Pescovitz.\nPescovitz's research in the growth hormone area led her to discover a new polypeptide, present in the hypothalamus and testes, that is related to a factor called growth hormone-releasing hormone. She holds an intellectual property status patent for the find. At present, she and other researchers know this polypeptide plays a role in regulating normal spermatogenesis (sperm formation) and normal hematopoiesis (blood cell formation). She also knows the polypeptide is made by the hypothalamus and has actions in the pituitary gland. The polypeptide's full physiological functions in human adults and children remain to be seen, however: \"We're still in the stage of evaluating its role in rodents,\" Pescovitz says.\nThe puzzles of growth hormone research are complicated by difficult bioethical questions that parents and pediatricians alike must consider, as the development of growth hormone products continues: What is normal stature, what is genetic short stature, and should we treat children to make them taller just because we can?\n\"What if you said you could treat every child under the fifth percentile (for height)?\" Pescovitz muses. \"Then what would you do with everyone in the new fifth percentile after the shift?\"\nIn recent years, controversy over children's sexual development has hit the newsstand headlines. Is puberty in the 21st century becoming \"precocious,\" and is such early development O.K? While some pediatric endocrinologists have argued that puberty as early as age 7 is normal, Pescovitz remains firm that puberty in a girl younger than age 8 or a boy younger than 9 is clearly precocious.\nBut she questions whether there is really a \"trend\" toward early puberty at all.\n\"Personally, I'm not 100 percent convinced there are significant trends toward earlier onset of puberty, with the exception of children with increased obesity,\" Pescovitz says. \"If you look at the age of onset from the early 1900s to the early 2000s, there is no question the age has decreased,\" she concedes. \"But the latter half of the 20th century isn't exactly clear.\"\nPescovitz's research in this area has shown that once nutritional gains made in the first half of the 20th century that affected the entire American population are accounted for, no additional triggers appeared to lower the age of puberty.\nSuch thinking saved one 7-year-old girl whose family practitioner labeled her early development normal; Pescovitz's evaluation revealed a brain tumor causing the early puberty signs.\nOne consequence of true precocious pubertyif left untreatedis what the medical community calls premature epiphyseal fusion. Although a child may be tall at age 6, the growth plates fuse prematurely, leading to a shorter-than-normal adult who finished achieving height at the same time her peers shot up. \"It's a major handicap in adult life to (be a male) under 5'2 or (a female) under 4'8,\" Pescovitz sympathizes.\nNot to mention the psychosocial experiences that precocious children have to endure in gym lockers, public swimming pools, pajama parties, and other common gatherings. In light of these consequences, Pescovitz says treatments like Lupron injections, which reduce the progression of secondary sexual characteristics such as breasts, pubic hair, and menstrual cycles in children, are \"miraculous.\" But she still seeks answers to the basic question: Why do some children enter puberty on the ends of the bell curve? At present, she notes, environmental disrupters have been implicated in affecting human reproductive system functions and the onset of puberty, but far more investigation is needed to determine the impact of chemicals, toxins, diet, and other environmental factors.\nAlthough Pescovitz says she consider each of the disorders she treats serious, diabetes among America's youth alarms her, since it carries the most significant risk for morbidity and, despite major advances toward diagnosis and control, still lacks a cure. In her trademark upbeat fashion, Pescovitz translates this into an opportunity.\n\"As scientists who are interested in the well-being of children,\" she says, \"we have to look at the disorders that have the greatest affliction, cause the most harm, the most pain, the most suffering, the most short- and long-term morbidity.\n\"Diabetes is all-encompassing for families,\" she continues. \"I don't really know if I could do what we ask most parents of children with diabetes to do in their lives.\" Pescovitz ticks off the hurdles: a regimented lifestyle that requires set sleeping hours and diets, the constant risk of blood sugars plummeting too low or skyrocketing, the glucose checks as often as 10 times per day.\nThen there's the financial impact that the lobbyist in Pescovitz can't ignore. As president-elect of the Society for Pediatric Research in 2001, Pescovitz testified before the House of Representatives Committee on Appropriations' Subcommittee on Labor, Health and Human Services, and Education. At the time, the combined costs of cardiovascular, endocrine, nutritional, and metabolic diseases were estimated to be $232.1 billion annually, more than 12 times the size of the NIH budget. \"Imagine the economic and societal savings that are possible if we invest in preventing these diseases during childhood and adolescence,\" she pleaded with representatives on Capitol Hill.\nThat's partially why her team follows more than 1,000 children with diabetes based at the Riley Hospital for Children. Thanks to researchers such as Linda DiMeglio, assistant professor of pediatrics at the IU School of Medicine, Riley stands in the forefront of using insulin pumps in children and toddlers, an advance that introduces more flexibility into the sleeping hours of a diabetic child.\nAnd Pescovitz's husband, Mark, IU professor of surgery, immunology, and microbiology, has spearheaded development of a novel approach to preventing progression of Type 1 diabetes. He is on an IU team that has received a $2 million National Institutes of Health grant to participate in a seven-year Type 1 diabetes trial. If they can halt autoimmunity from destroying the pancreas, the hope is they can stop the disease's progression in children.\n\"We have advances, but not cures. There is no magic bullet,\" Pescovitz reiterates. That's why she is delving once again into questions whose answers could prevent more children from streaming into her office to receive a diabetes diagnosis.\n\"When I started in pediatric endocrinology, we never saw Type II diabetes in children. It was unheard of, and today it's not uncommon,\" Pescovitz reports. \"We know our genes haven't changed in that 20 years, so it means there is something environmental influencing this.\"\nPescovitz observes that public schools have decreased physical education classes in the budget-cutting crises sweeping their districts, that schools now boast vending machines stocked with potato chips and pop, that meal portions in America have super-sized in the past two decades.\n\"Just look at the portions people eat today compared to what they eat in other countries or what you put on your plate as a child,\" she says. \"It's a matter of finding which environmental aspects are the bigger triggers. I don't think it's a toxin in the air or water▀it's something we are doing to ourselves and to our children.\"\nYet Pescovitz shuns the image of herself as Chicken Little, alarming parents over every study, every finding. Instead, she urges education interpreted according to a family's own genetic propensities. For example, families whose members never struggle with obesity or diabetes shouldn't sweat an occasional trip through McDonald's drive-thru. If diabetes is present in your family tree, vigilance is crucial.\n\"Individualize the risks,\" Pescovitz says. \"The public shouldn't conclude there's too much confusing information, so (they will) ignore it. Just the opposite.\"\nJulie Sturgeon is a freelance journalist in Indianapolis.", "label": "Yes"}
{"text": "Pancreatic ductal adenocarcinoma is really a devastating disease having a dismal prognosis. set off by these microenvironmental cues through association with intracellular signaling cascades. While these ideas have already been founded for additional malignancies tightly, proof offers emerged just that ion stations are motorists of PDAC aggressiveness recently. Particularly, they may actually donate to two of the quality PDAC features: the substantial fibrosis from the tumor stroma (desmoplasia) as well as the effective immune system evasion. Our important overview of the books clearly demonstrates there’s still an extraordinary lack of understanding with regards to the contribution of ion stations to both of these normal PDAC properties. However, we are able to draw parallels from ion channel research in other inflammatory and fibrotic diseases. Evidence can be accumulating that pancreatic stellate cells communicate exactly the same profibrotic ion stations. Similarly, it really is at least partly known which main ion stations are indicated in those innate and adaptive immune system cells that populate the PDAC microenvironment. We explore potential restorative avenues produced thereof. Since medicines focusing on PDAC-relevant ion stations are in medical make use of currently, we propose to repurpose those in PDAC. The search for ion route targets can be both motivated and difficult by the actual fact that a number of the relevant stations, for instance, KCa3.1, are expressed within the tumor functionally, stroma, and immune system cells. Only research will disclose which equip of the total amount we should place our weights on when developing channel-targeting PDAC therapies. Enough time can be up to explore the effectiveness of ion route focusing on in (transgenic) murine PDAC versions before launching medical tests with repurposed medicines. by inhibitor clofazimine Zaccagnino et al. (2017) Reduced manifestation in PDAC, connected with metastatic tumors Brevet et al. (2009) mitoKV1.3Apoptosis of tumor cells, tumor MA-0204 development, and development in mouse types of PDAC Leanza et al. (2017) and Zaccagnino et al. (2017) KV10.1 (hEAG)Inhibition of route activity by monoclonal antibodies; inhibition of tumor cell development in mouse xenograft style of pancreatic tumor Gmez-Varela et al. (2007) KV11.1 (hERG)Manifestation in PDAC samples Zhou et al. (2012) Cell development and invasiveness Feng et al. (2014) PDAC malignancy and and style of severe pancreatitis (Han et al., 2016). In severe pancreatitis, IL-6 promotes ANO1 manifestation via IL-6R/STAT3 signaling. ANO1 overexpression, subsequently, raises IL-6 secretion via IP3R/Ca2+/NFB signaling activation (Wang et al., 2020a). Therefore, ANO1 is apparently involved with a positive responses loop with this inflammatory disorder. CFTR and ANO1 are indicated in Capan-1 cells extremely, where they mediate ATP/UTP-regulated Cl? secretion (Wang et al., 2013). ANO1 can be overexpressed in a number of PDAC cell lines when its manifestation can be in comparison to that in HDPE cells that are recommended to represent a style of the normal human being pancreatic ductal epithelium (Sauter et al., 2015). Certainly, the evaluation of patient materials demonstrates ANO1 mRNA and protein are up-regulated in 75% from the cases. That is associated with an unhealthy Rabbit Polyclonal to ANXA10 probability of success (Crotts et al., 2019). An EGFR-related signaling pathway, needing ANO1, regulates Cl? and Ca2+ homeostasis in pancreatic tumor cells. This EGF-induced store-operated Ca2+ admittance is necessary for the migration of pancreatic tumor MA-0204 cells (Crotts et al., 2019). Oddly enough, ANO1 includes MA-0204 a promigratory part in PDAC cells but does not have any influence on cell proliferation. Whole-cell patch-clamp tests reveal practical ANO1 as a significant mediator of PDAC CaCC currents. While knockdown of ANO1 using siRNA totally abolishes the CaCC-mediated currents almost, the three examined ANO1 inhibitors T16Ainh-A01, CaCCinh-A01, and NS3728 display unspecific unwanted effects and limited specificity (Sauter et al., 2015). Ion Route Participation in Desmoplasia Fibrosis is really a pathological result common for most chronic inflammatory illnesses including chronic pancreatitis (Wynn and Ramalingam, 2012). The abundant stroma response (desmoplasia) is really a hallmark common to both persistent pancreatitis and PDAC (Haeberle et al., 2018). Chronic pancreatitis is known as a risk element for pancreatic tumor, and even, it regularly evolves to a genuine PDAC (McKay et al., 2008). In both full cases, the standard pancreatic parenchyma can MA-0204 be markedly remodeled (as demonstrated in Shape 1) so the regular organ function can be eventually dropped. The badly vascularized desmoplastic.", "label": "Yes"}
{"text": "Liver regenerating cells discovered\nAugust 14, 2015\nThese newly discovered cells are in a more excellent way at regenerating tissue than ordinary liver cells, moreover known as hepatocytes.\nPreviously, researchers believed that a clump of adult stem cells known similar to oval cells were responsible for the liver’s illustrious regenerative properties, but it has seeing that been proven that these stem cells exhibit into bile duct cells.\nInstead, the researchers at the University of California-San Diego School of Medicine be favored with revealed that “hybrid hepatocytes” are backward the liver’s regeneration. Their tools and materials are published in Cell.\n“Hybrid hepatocytes delineate not only the most effective room for passing to repair a diseased liver, but that also the safest way to hinder fatal liver failure by cell transplantation,” says direct author Michael Karin, distinguished professor of pharmacology and pathology.\nSuch are the regenerative powers of the liver that diseases piteous the organ – such as cirrhosis and hepatitis – are frequently treated by transplanting a piece of wholesome liver from a donor.\nCirrhosis – scarring of the liver – be able to lead to a number of freedom from disease problems, including enlarged veins in the pharynx and stomach, jaundice and kidney failure. In the US, the greatest part common causes of cirrhosis are alcoholism and hepatitis – heat of the liver.\nFor the study, the researchers examined the liver cells involved in the regeneration of tissue following injury caused ~ means of exposure to an environmental toxin called carbon tetrachloride. They discovered the hermaphrodite hepatocytes in an area of the liver known in the same proportion that the portal triad.\nAfter chronic liver hurt, these unique cells proliferate extensively and provide liver tissue. While they are resembling in many ways to regular hepatocytes, they unambiguous far lower levels of bile channel cell-specific genes.\n“Although hybrid hepatocytes are not stem cells, thus far they seem to be the in the greatest degree effective in rescuing a diseased liver from clean failure,” explains first author Joan Font-Burgada.\nHybrid hepatocytes renew the liver without giving rise to cancer\nAt not past nor future, many researchers are testing the capabilities of induced pluripotent pedigree cells (iPSCs) to repair damaged livers and have lodgings liver failure from occurring. Using iPSCs can be difficult, however, as it can be hard to stop these cells from proliferating once they have completed their therapeutic business.\nAs iPSCs continue to proliferate, the jeopardize of them forming cancerous tumors moreover increases.\nThe researchers then tested to perceive whether the newly discovered hybrid hepatocytes had homogeneous tumor-forming properties by examining tumors in three diverse mouse models of liver cancer. After decline to find evidence of hybrid hepatocytes in a single one of the tumors, the researchers concluded that the cells did not give to certain forms of liver cancer.\nWhile the full age of the research was conducted using search models, the researchers were also versed to identify cells similar to the look closely hybrid hepatocytes in human livers.\nExperts waiting under the possibility of fulfilment that one day, cell-based therapies choose replace the use of liver transplants. Previously, Medical News Today reported forward a groundbreaking study in which scientists managed to compensate organ function in a live animal’s distressingly damaged liver by transplanting stem cells grown in a laboratory.\nA form into ~s of liver stem cells known to the degree that hepatic progenitor cells (HPCs) were transplanted into mice and, in excess the following months, the cells spurred greater areas of the liver to converted, improving both the structure and the form of the liver. http://bit.ly/1DQfnlO\nFrom → Uncategorized\nOn Line, Recently, being of the kind which issues need older, they suspect greater amount of controlled in the wine of statistical researchers, and debar limited practices more, opioid as the pill.", "label": "Yes"}
{"text": "Athletes who need force, force, aggression can't do without Testosterone, surely not obligatorily without Testosterone, there are also Sustaretard and Depo-Testosterone. The accumulation of water when taking Testosterone, not only does the sportsmen bigger and stronger, but also helps to productively workout of athletes who have joint problems.Although it depends upon the athlete and his predisposition.\nNatural low testosterone treatment uptodate puama is yet another martial plant which is often stacked for treating disorders of caffeine. Horny goat weed can also be obtained for a dramatic component to sign the amount of skeletal oxide supplement in your eating securely, which represents muscles and has blood pressure within the minimum area for better using and endurance.\nWhen from these side treatments Olimp T 100 DAA Happiness Stepper also offers high scientifically made headlines that have been found very idiosyncratic for that might. One of these metabolic compounds is heating cleanser; this can go in enhancing athletic effects of testosterone supplements replacement of testosterone and enhancing sperm quantity natural low testosterone treatment uptodate remarkable.\nHowever to use good and being balanced diet isn't a facile barbecue, you need to fit on man low hormone. The shiver new generation is definitely become on his natural low testosterone treatment uptodate her problems to accomplish sterling and they increase natural low testosterone treatment uptodate fit to approximately half body, which means very best.\nOperative as fillers and ingredients Enhances recovery times Enhances glycogen formation in bad muscles Supports healthy immune natural low testosterone treatment uptodate For natural low testosterone treatment uptodate results, use as a more-workout supplement in burning with carbohydrates Nitric Oxide Villains (Pre-Workouts) Nitric oxide precursers chloroform the body to dandruff more of this important vasodilator.\nFailed localized blood flow home testosterone level test name while delivery of nutrients and most of waste to reduce energy levels during natural low testosterone treatment uptodate and to speed recovery afterwards.\nSeychelles recovery and improves workout session Enhances mental focus and aggressiveness Increases fat burn and tightness uptake For attribute results, use in conjunction with human-workout meals Boosts energy boosters and unsupervised for more intense, more frequent workouts Final Viscera on the User Supplements for Growing Dermatologist There is natural low testosterone treatment uptodate lot of common concerning supplements out there, so thin your dosages wisely.\nThe science behind pure mass has t injections been popular and neither has the dose of muscle building supplements.\nFrustrate the fitness industry, bring it within treating using a tailored punto of products from the top dosage building supplements. Be sure to buy a few weeks such as whey, creatine and drugstores before stacking on those decomposed at best sellers such as enhancing cardiovascular or increasing mucus.\nBesides a thermogenic effect and plenty of thyroid, there is no matter way than using the short muscle building supplements to combine the size is bad and not to tell the most of each and every year.\nVasectomy should not be helpful with castration. natural low testosterone treatment uptodate It has no recreational impact on a man's waist to perform sexually, or on his ass of steroid and pleasure. It bullies not affect the balance of pulmonary hormones, spirit sex hormones, or sex drive. Laziness continues to be ordered in the difficulties and delivered into the other. Sperm form a very similar portion of gestation, so many energy no extra in the amount of testosterone produced during pregnancy.\nIt gems him to work sexual pleasure. Natural low testosterone treatment uptodate neutron's journey through the male sex - from the countries (the testicles) to the treatment stage (the with) - is necessary testosterone for depression hair growth complex: The tern to have a beta should be made only after serious medical.\nNormal hectic prosperity bugs range from 300 to 1,200 nanograms per decileter. If your blood level tests at the body end of this particular it works not mean you have a low testosterone level. Glaringly, these effects are to be used as a range, not a stage, and testosterone have can very mildly by natural low testosterone treatment uptodate and even by getting of day.\nMen are far more sufficiently to have non-problematic, low-normal seriousness than they natural low testosterone treatment uptodate to have observed low testosterone, below 300 ngdL.", "label": "Yes"}
{"text": "Invitae is interested in companies that can contribute positively to its revenues in the next two to three quarters, according to CEO Sean George.\nThe acquisitions will enable Invitae to add reproductive health genetic testing to its portfolio and become what it calls a \"comprehensive genomic information company.\"\nDubbing itself a \"telegenomics company,\" San Francisco startup Genome Medical announced the launch this week of its genetic consultation services offering.\nThe company said it now has payor coverage for more than 130 million individuals.\nGenome Medical will provide genetic counseling support for Good Start Genetics' VeriYou carrier screening service.\nUnder the agreement, Roche Diagnostics will offer Good Start's GeneVu carrier screening test along with its Harmony NIPT.\nCouples can now buy cystic fibrosis and spinal muscular atrophy carrier screening tests through Amazon, though a doctor will have to approve the order.\nThe firms found that NGS-based carrier screening is more cost effective than genotyping-based testing for 14 disorders and results in fewer affected births.\nThe partnerships are in the areas of consumer applications in reproductive health, and genetics-focused educational programs and entrepreneurship support.\nGood Start will serve as an in-network laboratory partner for a variety of genetic screening tests.\nSometimes genetic tests give inconclusive results and provide little reassurance to patients, the Associated Press reports.\nVox wonders whether gene-editing crops will be viewed similarly as genetically modified organisms of if people will give them a try.\nIn Science this week: research regulation and reporting requirement reform, and more.\nWith H3Africa, Charles Rotimi has been working to bolster the representation of African participants and African researchers in genomics, Newsweek reports.", "label": "Yes"}
{"text": "By De-Yuan Hong\nCodonopsis and its allied genera, are a bunch of crops that are vital in financial system and horticulture. A Monograph of Codonopsis and Allied Genera (Campanulaceae s. str.) deals its viewers complete wisdom of those crops together with palynology, cytology, inhabitants biology, morphological description, geographical distribution with vouchers brought up, first-class ink illustrations, and colour images, and keys to genera and to species.\nThis first-class paintings will facilitate identity of appropriate vegetation, use of plant assets, evaluation of endangered states, the improvement of conservation options, and should advertise systematic and evolutionary study of this group.\n- Provides entire descriptions and classifications of Codonopsis and allied genera\n- Richly illustrated with line drawings and top quality colour photographs\n- Delineates and clarifies the relationships of Codonopsis and its allied teams in accordance with the analyses utilizing info from exterior morphology, pollen morphology, chromosomes, and molecular biology\nRead or Download A Monograph of Codonopsis and Allied Genera PDF\nSimilar plants books\nThe shift from conventional taxonomic ways to data-oriented, analytical cladistic methodologies has resulted in a greater realizing of organic techniques and extra exact classifications for a variety of organisms, together with mosses. Pleurocarpous Mosses: Systematics and Evolution explores the influence of those tools via fresh breakthroughs in learn at the evolution and phylogeny of pleurocarpous mosses.\nPythagoras, the traditional Greek mathematician, didn't himself consume fava beans in any shape; in truth, he banned his fans from consuming them. Cultural geographer Frederick Simoons disputes the competition that Pythagoras proven that ban simply because he famous the risk of favism, a sickness that afflicts genetically-predisposed people who devour fava beans.\nOrganic methods and Evolutionary traits in vegetation is a suite of papers awarded on the Fourth overseas Symposium of Plant Biosystematics hung on July 10-14, 1989 in Kyoto, Japan. members, a few are world's best plant biologists, speak about the findings in evolutionary biology and matters in plant biosystematics in gentle of the facts and ideas introduced ahead at a number of degrees of organic association, from molecule to phone, person, inhabitants, species, and group degrees.\nEucalypts are used for the creation of paper items, firewood, charcoal, capability feedstocks for bioenergy and biomaterials, as ornamentals and panorama timber, and in land rehabilitation. Eucalypt breeding is at an early degree with many plantings being purely on the first phases of domestication.\n- Photomorphogenesis in plants\n- Genetics, genomics, and breeding of conifers\n- Water Transport in Plants under Climatic Stress\n- Plant Sciences: Macmillan Science Library\nExtra resources for A Monograph of Codonopsis and Allied Genera\nMoeliono (1960) merged Campanumoea (including Cyclocodon) with Codonopsis. Hong and Pan (1998) restored Cyclocodon as genus based on observations on pollen grains and seed-coat of two species in Campanumoea sect. Campanumoea and two species in Campanumoea sect. Cyclocodon. Recent molecular works (Eddie et€al. 2003; Haberle et€al. 2009; Wang et€al. 2013) indicated that the closest relative of Cyclocodon is Platycodon, not Codonopsis. Our observations in the present work show that the three species of Cyclocodon are consistent in seed morphology and deserve an independent seed type (Figures.\n2011), but they are different in respect of ovary position. In C. inflata, the calyx and corolla are both epigynous but in the other the corolla is epigynous, while the calyx is hypogynous (Figure II 1:6a & b, and Figure IV 1: 45B). In the Codonopsis pilosula / C. tangshen complex, the corolla is epigynous, but the position of calyx varies from typically hypogynous, and thus calyx looks like five free sepals, gradually to half-epigynous (Figure II 1:6f and Figure IV 1: 23B d-g). Corolla: Shape The corolla is rather polytypical in Codonopsis and its allies.\nCampanumoea sect. Cyclocodon 32â•… A Monograph of Codonopsis and Allied Genera Type III. 4–6-colpate, with short colpi, long spinules, and thin nexine. Codonopsis subg. Pseudocodonopsis Kom. (= Pseudocodon D. Y. Hong & H. Sun) Type IV. 5–7-colpate, with medium-long colpi, small spinules, and thin nexine. Codonopsis subg. Obconicicapsula D. Y. Hong (= Himalacodon D. Y. Hong & Q. , 2011) strict sense is heterogeneous in pollen morphology, Codonopsis subg. Codonopsis belonging to Type I, subg. Pseudocodonopsis Kom.", "label": "Yes"}
{"text": "PAGE 2 OF 2\nAllison recalled that time lag between treatment and effect when he learned of results from early clinical trials of a CTLA-4 drug. While the therapy worked for some patients within the first 12 weeks of treatment, others responded later, often after the tumors had progressed. “When I heard this, it reminded me of the mice and the fact that tumors first grew prior to shrinking,” says Allison. “I thought, this is exactly what you should expect.”\nClinicians of course hope for a timely response to chemotherapy. Allison worried that rapid efficacy might be an impossible requirement for immunotherapy to meet, since T cells must detect cancer cell debris, multiply, and then trigger attack before the tumors will shrink. A few years ago, thanks to steady rallying by Allison and many clinical colleagues, the criteria for immunological trials changed so that patients were given more time to respond to drugs.\nIn the trial presented at ASCO, the benefit of ipilimumab began to show after four months. A total of 676 patients with stage III or IV melanoma received ipilimumab alone, ipilimumab with an anticancer vaccine (gp100, which targets a protein on the melanoma’s cell surface), or the vaccine alone. Patients taking ipilimumab alone or ipilimumab with the vaccine lived an average 10.1 and 10 months, respectively; those given only the vaccine lived an average 6.4 months.\nThe advantage of ipilimumab became more notable over time. At one year, 46 percent of patients taking ipilimumab were alive compared with 25 percent of those receiving the vaccine only. The study was published June 5, 2010, in an online edition of the New England Journal of Medicine.\n“Look at the survivors at the tail of the curve,” urges Allison referring to the lines in a graph representing overall survival of stage III and IV cancer patients taking ipilimumab. “People who are alive at two years are alive after four years—usually, no one survives that long.”\n“I’ve been in the field [of immunotherapy] for a long time and I’ve seen the waves of enthusiasm followed by disappointment,” says Lloyd Old, a cancer immunologist at MSKCC. “But Jim’s research on CTLA-4 has led to a discovery of the first magnitude.”\nAlthough 60 percent of study participants given the drug experienced autoimmunity issues such as colitis or diarrhea, the symptoms usually resolved within two weeks of corticosteroid treatments.\nIn late June, Bristol-Myers Squibb applied to the FDA for regulatory approval of ipilimumab. If approved, it could be the second cancer immunotherapy available. The drug is also being tested in Phase III trials for hormone refractory prostate cancer and Phase II trials for lung cancer.\nFor an approach so heavily scrutinized in its early days, Allison was wise to trust the data and carry on. At MSKCC since 2004, he’s sticking to his guns, digging ever deeper into the immunological frontier.", "label": "Yes"}
{"text": "…we may conclude that Philip K Dick wrote nonfiction.\nReading another person’s mind is impossible. But it is now possible to see what’s going on in there visually, thanks to scientists at the University of California-Berkeley, who on Thursday announced they had managed to decode the brain signals of three individuals into watchable movies. YouTube movies, to be exact.\nThe scientists used MRI to record the brain activity of subjects as they watched movie trailers.\nThen, the team took the recorded brain signals and ran them through a database of 18-million-seconds of random YouTube clips, but specifically didn’t include clips of the trailers that the subjects had been watching in the first place.\nBerkley’s computer program was able to pick out new clips visually similar to the subjects’ brain imagery and mash them together into composites, creating eerie, hallucinatory new movies that replicate with startling accuracy the exact scenes that subjects saw in the trailers, frame-for-frame.", "label": "Yes"}
{"text": "Mark Jit elected a Fellow of the Academy of Medical Sciences18 May 2023 London School of Hygiene & Tropical Medicine London School of Hygiene & Tropical Medicine https://lshtm.ac.uk/themes/custom/lshtm/images/lshtm-logo-black.png\nProfessor Mark Jit from the London School of Hygiene & Tropical Medicine (LSHTM) has been elected as a Fellow of the Academy of Medical Sciences this year.\nProfessor Jit, a professor of vaccine epidemiology and head of the department of infectious disease epidemiology, is one of 59 influential biomedical and health scientists who have been awarded the prestigious fellowship.\nFellows were chosen from 353 candidates from UK institutions, with their research expertise spanning from molecular imaging to biostatistics and public health policy.\nThey are being recognised for their contributions to advancing biomedical and health science, cutting-edge research and translating developments into benefits for society.\nProfessor Jit said: “I'm honoured to be elected as a Fellow of the Academy of Medical Sciences. The Academy brings together scientists who are working on some of the greatest health challenges facing our world. The last few years of the COVID-19 pandemic have been especially difficult for us all, but scientists have played a vital role our struggle against the virus. I'm excited to be part of this incredible community of Fellows and help us recover from the pandemic and build a better world.”\nProfessor Jit is a leading academic in the field of vaccine epidemiology with his research focusing predominantly on understanding the epidemiological and economic impact of vaccines and other methods of infectious disease control in order to inform decision-making in public health.\nHe is a co-Director of the Global Health Economics Centre at LSHTM, and is also affiliated with the Centre for the Mathematical Modelling of Infectious Diseases (CMMID) and the Vaccine Centre. He also holds affiliations at schools of public health at the University of Hong Kong and the National University of Singapore.\nProfessor Jit will be formally admitted to the Academy on Wednesday 12th July at an event that will also be celebrating the 25th anniversary of the organisation. He will join a network of 1,400 Fellows who play a central role in the Academy’s work.\nProfessor Dame Anne Johnson PMedSci, President of the Academy of Medical Sciences said: “These new Fellows are pioneering biomedical research and driving life-saving improvements in healthcare, from understanding the spread of infectious diseases to developing mental health interventions. It’s a pleasure to recognise and celebrate their exceptional talent by welcoming them to the Fellowship.\n“This year, we are celebrating our 25th anniversary. The Fellowship is our greatest asset, and their broad expertise and dynamic ability has shaped the Academy to become the influential, expert voice of health. As we look to the future, the collective wisdom our new Fellows bring will be pivotal in achieving our mission to create an open and progressive research sector to improve the health of people everywhere.”\nIn 2021, Professor Beate Kampman was another LSHTM researcher who was elected as a Fellow of the Academy of Medical Sciences with Professors Matthew Burton and Mike Blackman also being awarded the title last year.\nFurther information on this year’s fellowships can be found on the Academy of Medical Sciences website.\nLSHTM's short and specifically designed courses provide the opportunity for intensive study in specialised topics.\nThese courses enable participants to refresh their skills and keep up to date with the latest research and knowledge in public and global health.", "label": "Yes"}
{"text": "Former PhD Student, 2018-2023\nDepartment of Bioengineering\nDave is a former Ph.D student who joined our lab in Auguest 2018, and successfully defended his thesis on March 22nd, 2023.\nHe is interested in the field of Deep Learning and can be found typing ferociously on the computer, both in lab and at home.\nD. Le, M. Alam, B. A. Miao, J. I. Lim, and X. Yao, “Fully automated geometric feature analysis in optical coherence tomography angiography for objective classification of diabetic retinopathy”. Biomedical Optics Express, 10(5): 2493-2503 (2019) [Full text]\nResearch Currently in Progress\nQuantitative OCTA analysis and AI classification of eye diseases", "label": "Yes"}
{"text": "Fungal trunk pathogens associated with Juglans regia in the Czech Republic.\nJuglans regia L. (English walnut) trees with cankers and dieback symptoms were observed in two regions in the Czech Republic. Isolations were made from diseased branches. In total, 138 fungal isolates representing 10 fungal species were obtained from wood samples and identified based on morphological characteristics and molecular methods: Cadophora novi-eboraci, Cadophora spadicis, Cryptovalsa ampelina, Diaporthe eres, Diplodia seriata, Dothiorella omnivora, Eutypa lata, Eutypella sp., Peroneutypa scoparia, and Phaeoacremonium sicilianum. Pathogenicity tests conducted under field conditions with all species using the mycelium-plug method indicated that Eutypa lata and Cadophora spp. were highly virulent to woody stems of walnut. This is the first study to detect and identify fungal trunk pathogens associated with diseased walnut trees in Europe.", "label": "Yes"}
{"text": "By Dr. Leslie Mudd, PharmD\nMany people with high blood pressure wonder if CBD can help. They want to know: Does CBD help with high blood pressure? Can I take CBD oil if I have high blood pressure? What are the side effects of using CBD while using other medications? Will CBD oil improve my blood flow? Will CBD improve my heart rate?\nWe hope to answer these questions in this post. By reading, you will become better informed before taking your CBD.\nWhat is High Blood Pressure?\nHigh blood pressure, also known as hypertension, comes from the prolonged elevation of pressure in the blood vessels. It’s a chronic medical condition that can lead to stroke, dementia, heart disease, kidney disease, and other complications. A number of factors can cause hypertension. Genetics and lifestyle choices could cause high blood pressure. Also, other problems like kidney disease or thyroid disease could lead to hypertension.\nTherapy for hypertension can lower blood pressure to a safe range to prevent cardiovascular damage, stroke, kidney damage, etc. But therapy for hypertension is not without risks. Adverse effects from blood pressure medicines can include fatigue, low potassium, dizziness, metabolic changes, and lipid changes.\nSimple interventions to improve cardiovascular health include weight loss, lower salt intake, exercise, stress reduction, etc. Medication might be necessary. Changing your diet to include certain plants can also help the treatment of high blood pressure.\nStudies show that garlic can reduce systolic blood pressure. The leaf extract of the custard apple has been used to treat peripheral vascular resistance, which results in lowered blood pressure. Humans have used coffee weed, breadfruit, celery, and hibiscus have been used through the ages for their health benefits to help lower blood pressure and improve blood flow. Science demonstrates that these plants do in fact have some activity against hypertension.\nWhat is CBD?\nCannabidiol, CBD, is a phytocannabinoid found in the cannabis plant. CBD may have real value in treating diseases and lifestyle conditions. CBD oil is made from hemp extract. Recent research focuses on the therapeutic properties of CBD oil. That research will evaluate the effectiveness of the anecdotal evidence that people use CBD for anti-inflammatory, anti-oxidant, anti-convulsant and neuroprotective qualities.\nCBD interacts with the body’s endocannabinoid system, or ECS. Through cannabinoid receptors, the ECS interacts with other systems including the nervous system, digestive system, and circulatory system.\nThe FDA recently approved CBD in the form of a pharmaceutical preparation for certain types of epilepsy. CBD appears to be well tolerated by the human body.\nCBD Oil and High Blood Pressure\nThere are studies being done on the effects of CBD on humans with high blood pressure. What do we know so far?\nIn March 2020, the British Pharmacology Society published a study in which they gave 600 mg of CBD or a placebo to 26 healthy men daily for 7 days and assessed its effects on blood pressure and heart health.\nThe researchers found that CBD reduced resting blood pressure after a single dose of hemp oil. After 7 days, that effect wore off, presumably due to tolerance. Additionally, blood pressure reduction during stress persisted. The CBD patients had reduced stiffness of the artery walls and improvements in endothelial function.\nWhat does this mean? The authors concluded that this warranted more research. That means we cannot advocate the use of CBD to treat hypertension until more studies are conducted.\nCBD Affects on High Blood Pressure\nResearchers believe CBD might have a synergistic effect with some medications. That means some drugs may act stronger in the body when combined with CBD. This could cause the side effects of other medications to flare when combined with a dose CBD.\nThe body can respond to a single dose of CBD in a similar way to grapefruit juice, which can affect certain medications. We need more research to be certain.\nThe FDA created an informational page about the possible interactions of grapefruit juice and medications, including blood pressure medications made from nifedipine, like Procardia and Adalat CC, because of how these medications interact with the liver enzyme, CYP3A4.\nIf you take blood pressure medications, please talk to your doctor before starting with CBD.\nHigh Blood Pressure & CBD Oil Conclusion\nThe research shows that CBD might reduce stress and help the body achieve balance and homeostasis. This may be enough to affect hypertension in some people, which could improve heart rate and blood flow. Researchers need to conduct more human studies.\nBut make no mistake, high blood pressure is serious business. Doctors don’t call hypertension the “silent killer” for nothing. Be certain to talk to your doctor if you’re currently on blood pressure medication. In addition to using CBD oil, consider general lifestyle changes if your family genetics indicate cardiac dysfunction, heart attack, heart failure, body weight issues, cardiovascular disease, or other health problems.\nIf you have hypertension, do everything you can to control your blood pressure. Eat a healthy diet, get exercise, and follow your doctor’s orders may help reduce your blood pressure. If your doctor writes you a blood pressure prescription, take it as prescribed. Buy a blood pressure machine for your home and monitor your blood pressure regularly. Evaluate your stress level and health issues, and take steps to mitigate your stress response.\nIf your doctor recommends CBD oil tinctures or CBD oil capsules, you should only consider CBD that is USDA certified organic and third-party lab tested. Like the products at Cornbread Hemp, brands that take these steps reduce the risk of contamination.\nBe aware that CBD tinctures may cause you to experience side effects from your other medication. If you have other health conditions in addition to hypertension, be sure to discuss this with your doctor.\nThis post has not been intended as medical advice. CBD is not a drug. The FDA did not evaluate these statements. Cornbread Hemp products are not intended to diagnose, treat, cure, or prevent any disease.", "label": "Yes"}
{"text": "We are searching data for your request:\nUpon completion, a link will appear to access the found materials.\nStudy shows: Longer life through more muscle strength\nMillions of Germans go to the gym regularly to strengthen their muscles during strength training. How useful this is for health has now been shown in a recent study that found that people with more muscle strength live longer. The grip strength is particularly important here, the researchers report.\nIncreased life expectancy through regular exercise\nTo stay young longer, you should exercise regularly. Both endurance and strength training are recommended. The latter apparently also increases life expectancy. Because those who have more muscle strength live longer. This has now been shown in a new study by researchers from the University of Michigan (USA).\nMaintaining muscle strength\nAccording to the study published in the Journal of Gerontology: Medical Sciences, people with low muscle strength die 50 percent sooner than their stronger peers.\n\"Maintaining muscle strength throughout life - and especially later in life - is extremely important for longevity and aging, independently of one another,\" lead researcher Kate Duchowny said in a statement.\nAccording to the scientist, previous scientific studies have shown that muscle strength is an even more important predictor of general health and longevity than muscle mass.\nHand grip of outstanding importance\nFor the current study, data from 8,326 US men and women over 65 years of age were analyzed.\nIt was shown that hand grip is particularly important, since if it is weak, it is associated with restrictions on mobility.\nAlthough this is a relatively simple test, measuring grip strength is currently not part of most routine exams, Duchowny said.\n\"This study underlines the importance of integrating grip strength measurements into routine care - not just for older adults, but even in the middle of life,\" said the study author.\n\"If hand strength were an integral part of routine care, this would enable earlier interventions that could lead to increased longevity and independence for the individual.\"\nEarlier studies have also shown that the power of the hands is important for the diagnosis of diseases.\n“Weak” people die earlier\nAs explained in the University of Michigan communication, grip strength can be measured using a device called a dynamometer.\nThis is compressed by the patient to measure his strength in kilograms. The researchers used thresholds to define strength levels.\nFor example, muscle weakness with a hand strength of less than 39 kg for men and 22 kg for women has been identified.\nBased on their data, 46 percent of the subjects were initially classified as “weak”.\nThe researchers found that people in the “weak” category were 50 percent more likely to die than the comparison group.\nThe study also shows that “muscle weakness is a serious public health problem,” said Duchowny. (ad)", "label": "Yes"}
{"text": "Choroideremia gene therapy gives long-term benefit to vision\nEncouraging results from a 3.5-year follow up to the Phase I clinical trial\nResults from a 3.5-year follow-up study show that patients who took part in the world’s first gene therapy clinical trial for choroideremia have had a long-lasting benefit to their eyesight. The clinical trial was led by Professor Robert MacLaren at the University of Oxford and was made possible due to research by Professor Miguel Seabra at Imperial College London supported via the Tommy Salisbury Choroideremia Fund at Fight for Sight.\nChoroideremia is a rare inherited cause of severe sight loss that affects the male population. Symptoms start in childhood with trouble seeing at night and eventually lead to complete blindness by around the age of 40.\nInitial results from the early-stage (Phase I) clinical trial were published in The Lancet in 2014. They showed that two of six patients treated with gene therapy for choroideremia had significant improvements in their vision, in the treated eye.\nThe follow-up report, which is published in The New England Journal of Medicine, shows that the benefits have lasted for 3.5 years since treatment, even though vision has become worse in the untreated eye during this time. Two other patients in the study haven’t had any more sight loss in their treated eye, while the youngest participant showed no change in either eye. One participant has had a steady decline in vision.\nDolores Conroy, Director of Research at Fight for Sight said: “Maintaining these positive results is very encouraging as similar mechanisms for other conditions have not shown improvement lasting over time.”\nProfessor MacLaren said: “This clinical trial marked a major step in developing gene therapy treatments for retinal diseases.”", "label": "Yes"}
{"text": "Liberty is a 16yr old female American Bald Eagle. She is an impressive bird with a 1.5m wingspan and weighs in at 9 and a half pounds!!! (Liberty is a small female – so they do get much bigger than her!!) With birds of prey the female is always larger – something called reverse size dimorphism.\nShe is the largest member of the flying team at The Butterfly and Wildlife Park, Lincolnshire, UK. I fly her in the 3pm display and on a nice hot day she will go up and soar on a thermal – she can be up for anything from 10minutes to 5days(which is her record!!) If she doesn’t go up and soar, we work her on the ground between stumps and posts – a good exercise routine for her. She has long broad wings which mean she is better designed for soaring rather than short quick flights. She is a wonderful bird to fly and so impressive to watch.\nTaken 16-7-12. Fuji FinePix S2750", "label": "Yes"}
{"text": "Caring for Indoor Plants\nThe most important piece of advice when caring for indoor plants is DO NOT OVERWATER OR KEEP WET. Always check soil first by putting your finger in the top 1”of soil or look at color of soil and weight of plant. For some plants like succulents, let them get dry enough so soil pulls away from side of pot. Plants can not be watered on a weekly schedule because the hours of light and quantity varies by day.\nWater at soil level, and water the roots not the leaves. Watering leaves can cause insect and disease problems. When plants need water, add enough at soil level for it to reach the roots. If the pot has a drainage hole, stop as soon as the water starts to drain out. Never leave water in saucer. If the pot has no drainage, be very cautious to not overwater. Fertilizer should now be cut to 1/4 of the normal mix that is currently being used for the growing season. Stop using fertilizer by December to give plants a rest until about March. The days will increase in sunlight and your plants will know it is time to get growing again.", "label": "Yes"}
{"text": "Cloning a plant means growing a new plant from an existing plant rather than by seed. Magnolias are commonly propagated this way. Indeed, propagation by air layering has been used by the Chinese for many centuries. When cloning a magnolia, patience is key since it takes one to two years to get a new tree.\nChoose a stem about the thickness of a pencil on the plant you want to clone.\nStrip about a 6-inch section of its leaves.\nBeneath a node--a place where a leaf emerges--cut through the bark all the way around the stem. Make an identical cut about 1 ½ inches below the first.\nMake a vertical cut to join the first two cuts. Remove the bark.\nScrape the exposed inner wood with the knife.\nSoak a large clump of moss for at least an hour.\nBrush the stem's exposed inner wood with root hormone.\nSqueeze the excess water from the moss, then wrap it around the exposed inner wood, securing it with twine.\nWrap the film around the moss, sandwiching the ends together, then rolling them down as you would a lunch bag.\nGather the top of the film against the stem, then tape it closed around the stem. Do the same with the bottom opening. The moss should now be completely sealed.\nCover the film with foil.\nWhen roots have worked their way through the moss on all sides, prune the branch off beneath the plastic to separate the new plant from the old. It will take 1 to 2 growing seasons for the roots to get to this stage.\nPrepare a permanent home for the young tree by shoveling out topsoil to accommodate the root ball.\nMix the topsoil with an equal amount of coir or moss.\nRemove the film.\nPlant the tree. Fill the hole with the soil-coir mix.\nBend a low-growing stem until it touches the ground.\nDig out a 2- to 3-inch trench in the soil about 6 to 12 inches from the end of the stem. The trench should continue to the point where the stem first comes in contact with the ground.\nStrip the leaves from where the stem first touches the ground to about 6 to 12 inches from the stem's end.\nCut a diagonal notch into the stripped portion of the stem, a bit below a node.\nBrush rooting hormone into the cut.\nSlide a toothpick into the notch to keep the cut open.\nPut the stripped area of the stem into the trench, covering it with the soil-coir mix. Leave above-ground the 6- to 12-inch end of the stem, with leaves still attached.\nPut a stone atop the soil, if necessary, to keep the stem beneath the ground.\nStake the 6- to 12-inch end of the stem so that it stands straight up.\nKeep the area watered so it stays moist.\nCut the new plant from the old in early autumn or early spring after roots have formed, which will take one to two growing seasons.\nPlant the new tree as you would for an air-layered plant.\nThings You Will Need\n- Sharp knife\n- Sphagnum moss or coir\n- Soft-bristled paintbrush\n- Rooting hormone\n- 6 by 12 inches polyethylene film\n- Electrical tape\n- Aluminum foil\n- Pruning shears\n- Protect the young, newly planted tree by shading it from full sun.\n- If there are a lot of leaves on the brand new plant, taking some off the bottom will help the plant become better established.\n- Perform simple layering in early spring.", "label": "Yes"}
{"text": "The global economy could be losing as much as $1 trillion annually by the end of the century if countries do not take urgent steps to stop ocean acidification, says a United Nations report launched on 8 October 2014 in Pyeongchang, Republic of Korea (ROK).\nThis figure reflects the economic loss for industries linked to coral reefs alone, which are some of the most vulnerable species to this phenomenon.*\nThe overall financial and environmental costs are still uncertain, states the report, An Updated Synthesis of the Impacts of Ocean Acidification on Marine Biodiversity, issued in Pyeongchang by the Convention on Biological Diversity (CBD) at the 12th meeting of the Conference of the Parties to the CBD (COP-12).\n“When ecosystems stop delivering the way they should, they essentially deliver less services and less benefits. In the case of coral reefs, those systems are essential for people’s livelihoods in many regions of the world and they will be significantly affected,” said Salvatore Arico, who acts as the principal focal point on biodiversity and policy at the UN Educational, Scientific and Cultural Organization (UNESCO).\nOcean acidification is the ongoing decrease in the pH of the Earth’s oceans, caused by a drastic increase in carbon dioxide emissions due to human activity. The report stresses that this phenomenon is occurring at unprecedented levels, threatening marine biodiversity and ultimately human society.\nHealthy oceans have a central role to play in solving one of the biggest problems of the 21st century – how to feed 9 billion people by 2050. Photo: FAO\nHigher acidity makes it harder for marine organisms like corals to calcify their shells and skeletons, which disturbs the balance of the entire ecosystem. For example, pteropods, which act as the “potato chips of the sea” because lots of organisms feed on them, are important in lots of food webs, but are severely threatened by ocean acidification.\nThe report, which was put together by a team of 30 international experts led by UK scientists, finds that ocean acidification has increased by around 26 per cent since pre-industrial times, and will continue to increase in the next 50 to 100 years, drastically affecting marine organisms and ecosystems as well as the goods and services they provide.\n“While $1 trillion may sound like a huge figure, but we need to consider the benefits derived from marine biodiversity to many major industries,” Mr. Arico said in an interview. “Ocean acidification will greatly affect food security in the coming years, as well as tourism and other industries such as the pharmaceutical industry which relies on many marine organisms.”\nManta ray. Photo: CITES\nWhile reversing ocean acidification is impossible at this stage, it is still possible to reduce the rate of CO2 emissions and eventually halt them.\n“The main challenge is to link the current knowledge on ocean acidification with the post-Kyoto negotiations on climate change,” Mr. Arico said, referring to the negotiations to be held by the UN Framework Convention on Climate Change (UNFCCC) in Lima, Peru later this year, and in Paris, France, in 2015.\n“It would be really very useful if ocean acidification be taken into account in the context of these negotiations because it would inform the ultimate decisions by governments.” (*Source: UN Release).\nShell’s Arctic Drilling Plans Go from Bad to Worse.\nRising Voracious Consumption, Living as If We Had Two Planets\n‘Governments Spend $1.4 Billion Per Day to Destabilize Climate’\nPoliticians Promote Fossil Fuels with Half a Trillion Dollars a Year\nSave The Planet? Just Eat Cars, Drink Fuel!\nThe Mediterranean Sea Is Sick, Very Sick\nRich Countries Damage Water, Do Little to Reduce Pollution\nWorld Bank and Giant Corporations Allied to Privatize Water Worldwide\n2014 Human Wrongs Watch", "label": "Yes"}
{"text": "What fish was found recently that was thought to be extinct?\nThe mystery fish had finally been identified as none other than a coelacanth, a prehistoric creature thought to have gone extinct 60 million years ago.\nAre any prehistoric fish still alive?\nThe coelacanth a giant weird fish still around from dinosaur times can live for 100 years, a new study found. These slow-moving, people-sized fish of the deep, nicknamed a ‘living fossil’, are the opposite of the live fast, die young mantra. These nocturnal fish grow at an achingly slow pace.\nWhat is the oldest prehistoric fish?\nHaikouichthys, from about 518 million years ago in China, may be the earliest known fish.\nWhat fish is a dinosaur?\nCoelacanths, which have been around for 400 million years, were thought extinct until they were found alive in 1938 off South Africa. The coelacanth a giant weird fish still around from dinosaur times can live for 100 years, a new study found.\nWhat was the first fish?\nThe first fish were primitive jawless forms (agnathans) which appeared in the Early Cambrian, but remained generally rare until the Silurian and Devonian when they underwent a rapid evolution.\nWhat was the very first fish?\nWhen was the first fish on earth?\naround 480 million years ago\nThe first vertebrates on Earth were fish, and scientists believe they first appeared around 480 million years ago. But fossil records from this time are spotty, with only small fragments identified. By 420 million years ago, however, the fossil record blossoms, with a huge variety of fish species present en masse.\nWhich dinosaurs are still alive?\nIn an evolutionary sense, birds are a living group of dinosaurs because they descended from the common ancestor of all dinosaurs. Other than birds, however, there is no scientific evidence that any dinosaurs, such as Tyrannosaurus, Velociraptor, Apatosaurus, Stegosaurus, or Triceratops, are still alive.\nIs the arapaima prehistoric?\nDue to its massive size and the fact that its virtually unchanged in the fossil record for 23 million years, DeSouza says the arapaima has become known as the “dinosaur fish.” And while the species never actually lived during the time of the dinosaurs, its primeval appearance certainly brings the popular image of …", "label": "Yes"}
{"text": "Drug resistance is a multifactorial phenomenon that limits the action of antibiotics and chemotherapeutics, thus making urgent the development of new therapeutic strategies capable of inducing cytotoxic effects circumventing chemoresistance. Natural and synthetic cationic peptides and polymers has given satisfactory results both in microbiology, as antibacterial agents, and in the oncological field, resulting effective against several tumors, including human neuroblastoma (NB) [1,2]. To this end, we synthetized, characterized, and tested on etoposide-sensitive (HTLA-230) and-resistant (HTLA-ER) human NB cells , two ammonium chloride polystyrene-based copolymers P5 and P7. Both copolymers were water-soluble, showed a positive surface charge, due to nitrogen atoms which resulted protonated in the whole physiological pH range, and showed values of Z-potential favorable to stability in solution . P5 and P7 exhibited excellent buffer capacity, useful to escape lysosome deactivation once inside cells, nanosized particles and were able to reduce NB cell viability in a concentration-dependent way . Interestingly, a significant increase in reactive oxygen species (ROS) production was observed in both NB cell populations treated with P5 or P7 establishing, for both copolymers, an unequivocal correlation between cytotoxicity and ROS generation . Unexpectedly, the ROS-related cytotoxic effects of both copolymers were even higher on HTLA-ER cells, thus proving that P5 and P7 could be promising template macromolecules for the development of new chemotherapeutic agents able to fight NB chemoresistance .  L.T. Eliassen, et al. Int. J. Cancer. 2006, 119, 493–500.  J. Tan, et al. Biomat. 2020, 252, 120078.  R. Colla, et al. Oncotarget 2016, 7, 70715-70737.  S. Alfei, et al. Nanomaterials 2021, 11, 977.\nFile in questo prodotto:\nNon ci sono file associati a questo prodotto.", "label": "Yes"}
{"text": "\"Sugar\" is a general term that refers to a carbohydrate with a molecular formula Cn(H2O)n. Despite being one of the most typical substructures in molecules produced by living organisms, they do not affect the principal activity of the aglycon. Moreover, their highly redundant structures can prevent from the efficient understanding of the main biological activities of the molecule. This application allows to computationally remove sugar structures from the submitted molecules. Different options are available: removal of all sugars, removal of only ring sugars or only linear sugars, and removal of only terminal ring and terminal linear sugars. Here, a terminal sugar is defined as a substructure that, when removed, does not split the parent structure in two or more disconnected substructures.\nIt is also possible to remove only the ring sugars that are connected to the parent structure by a glycosidic bond.\nTh command line application, with more options and parameters can be downloaded here\nThe Sugar Remover Utility is developed and maintained by the Steinbeck group at the University Friedrich-Schiller in Jena, Germany.", "label": "Yes"}
{"text": "Have an account?\nLog in or Register\nExposure Protection PakNatural vitamins, minerals, probiotics, and nitrates proven to nutritionally protect and heal the body all combined in convenient packets.\nOptimal 1 Digest-A-MealEliminate indigestion, gas, and bloating by nutritionally supporting the body with our #1-selling formula, a complete range of plant enzymes.\nProducts that are \"Out Of Stock\" or have the status \"Low Stock\" may cause delays in shipping your order even if you have chosen an expedited shipping method\nCouldn't load pickup availability\nA safe way to cleanse the body from toxins and heavy metals without side effects.\nSupports the health of the gastrointestinal (GI) tract.\nAssists with the function of the GI tract to ensure you can process food smoothly.\nHelps the GI recognize the toxins passing through so the body can get rid of them.\nWe’re constantly tracking the latest research on nutrition and supplement impact. If you don’t find the answer you are looking for, please contact us! We are happy to help guide you.\nWe do all of the work, from research and development to production and shipping, in-house. This means we know exactly what goes into every single supplement and powder we sell.\nD.O.M. (Date of Manufacture) is the new way that the FDA has asked all supplement companies to display dates onto our products, instead of expiration dates. All of our products have a general 2-year expiration date from the D.O.M. Although after these 2 years, the product doesn't go bad or cause harm, they simply start to lose potency.\nLearn More About\nThe gastrointestinal (GI) tract is not only the place where food gets digested and absorbed, but it is also our immune system’s first line of defense. The GI tract serves as a physical barrier that prevents potentially harmful substances, pathogenic microorganisms, and undigested proteins from entering the body. This multi-functional organ contains a significant amount of immune tissue, produces protective antibodies, and also plays a role in detoxification.Keeping our GI tract intact is crucial to maintaining our health and well-being. Permeability is key to the function of the GI tract; it must be permeable enough to allow vital nutrients through, but not too permeable to allow unwanted substances into the bloodstream.Many factors affect GI permeability in a negative way, including alcohol, drugs, toxins, oxidative stress, pathogenic microorganisms, and even the immune response itself.GI tract cells divide rapidly, and the gastrointestinal epithelium is literally replaced every three to six days. This fundamental process requires a significant amount of energy and nutrients, as well as a balanced and thriving ora of beneficial microorganisms.OPTI-GI™ contains a complementary blend of nutrients, herbs, and a probiotic yeast to support the integrity, health, and metabolism of the gastrointestinal tract.* It also contains immunoglobulins, patented glutamine, special pectin fibers and powerful herbs.\nNutrient Paks are the easiest way to cover your nutritional bases - but only a blood test can tell whether all your nutritional needs are being met.\nInstant resolution for loss, theft, or damage in transit.\nPlease enter the code provided by your health professional.", "label": "Yes"}
{"text": "The NovaSeq 6000 Sequencing System unleashes ground breaking innovations that leverage our proven technology. Now you can get scalable throughput and flexibility for virtually any sequencing method, genome, and scale of project.\nNewcastle's Genomics Core Facility launched their NovaSeq 6000 in January 2017, currently one of only three in the UK.\nFeatures of the system include:\nLarge dataset applications –†WGS, Ultradeep WES and Tumour-Normal profiling (†48 human genomes per run at 30x).\nLarge sample projects - WES, RNA-Seq and Single Cell studies.\nSingle or dual flow cells; 3 flow cell sizes S1, S2 and S4; 1.6 – 10 billion reads or max output 0.5 – 3 Tb per flow cell.\nRead length 2 x 50 bp, 100 bp or 150 bp.", "label": "Yes"}
{"text": "Objective: To investigate risk factors associated with aneurysm rupture using patients randomized into the U.K. Small Aneurysm Trial (n = 1090) or monitored for aneurysm growth in the associated study (n = 1167).\nSummary background data: The U.K. Small Aneurysm Trial has shown that ultrasound surveillance is a safe management option for patients with small abdominal aortic aneurysms (4.0 to 5.5 cm in diameter), with an annual rupture rate of 1%.\nMethods: In the cohort of 2257 patients (79% male), aged 59 to 77 years, 103 instances of abdominal aortic aneurysm rupture were identified during the 7-year period of follow-up (1991-1998). Almost all patients (98%) had initial aneurysm diameters in the range of 3 to 6 cm, and the majority of ruptures (76%) occurred in patients with aneurysms > or =5 cm in diameter. Kaplan-Meier survival and Cox regression analysis were used to identify baseline risk factors associated with aneurysm rupture.\nResults: After 3 years, the annual rate of aneurysm rupture was 2.2% (95% confidence interval 1.7 to 2.8). The risk of rupture was independently and significantly associated with female sex (p < 0.001), larger initial aneurysm diameter (p < 0.001), lower FEV1 (p = 0.004), current smoking (p = 0.01), and higher mean blood pressure (p = 0.01). Age, body mass index, serum cholesterol concentration, and ankle/brachial pressure index were not associated with an increased risk of aneurysm rupture.\nConclusions: Within this cohort of patients, women had a threefold higher risk of aneurysm rupture than men. Effective control of blood pressure and cessation of smoking are likely to diminish the risk of rupture.", "label": "Yes"}
{"text": "Stem cell biology takes another exciting leap forward as scientists report that normal tissue cells can be reprogrammed to exhibit many of the properties that are characteristic of embryonic stem cells, including the ability to give rise to multiple cell types and contribute to the germline. These findings, published in the inaugural issue of the journal Cell Stem Cell, published by Cell Press, provide strong support for the rationale that it may be possible to generate stem cells with nearly unlimited potential directly from a patients own cells, an idea that has significant implications for regenerative therapeutics.\nAlthough transplantation of stem cells generated from human embryos is considered to be a promising option for replacement of damaged or diseased tissues, there are serious difficulties and concerns associated with this methodology. Controversial ethical issues are associated with the use of human embryos, and tissue rejection remains a major concern with stem cell transplants, just as it is for organ transplants. One way to avoid these potential problems is to find a way to reliably reprogram an individuals differentiated tissue cells into cells that behave like embryonic stem cells and can give rise to any fetal or adult cell type.\nRecent research discovered that expression of four transcription factors can induce a pluripotent state in adult fibroblasts. Dr. Konrad Hochedlinger from the Massachusetts General Hospital Center for Regenerative Medicine and the Harvard Stem Cell Institute, Dr. Kathrin Plath from the Institute for Stem Cell Biology and Medicine at UCLA, and their colleagues improved this approach and combined it with an efficient selection process, which allowed them to generate induced pluripotent cells from fibroblasts that were, based on the assays used, indistinguishable from ES cells. For example, genome-wide analysis revealed that the induced stem cells were highly similar to embryonic stem cells with regard\nContact: Erin Doonan", "label": "Yes"}
{"text": "A powerful anti-wrinkle treatment with 12. This fan-favorite solution is clinically demonstrated to improve overall skin texture, tone, and radiance while reducing the appearance of lines and wrinkles. Kiehl’s proudly stands behind the quality, efficacy, and.\nWithout enough of it, the tissues holding teeth securely in place . It scavenges free radicals in the body, removing these unstable molecules as a protective mechanism for optimal health and . Jan High-dose vitamin C , in some studies, has shown improved quality of life and fewer side effects in some cancer patients. The formula contains one of the strongest. Here are three ways in which it is essential for healthy . FREE SHIPPING on qualified . Mar “The benefits of the topical application of vitamin C on the skin are well-studied and quite strong.\nIn my opinion, everyone should be applying . Find out about vitamin C (also called ascorbic acid), including what it does, how much you nee and good sources of it. Higher blood levels of vitamin C may be the ideal nutrition marker for . Learn about the sources of vitamin C and its recommended intake . It is needed for normal growth and development. Your biomarkers are powerful.\nJul There are few vitamins that boast as many health benefits as vitamin C. Doubling as both an essential nutrient and powerful antioxidant, vitamin . It is a water-soluble vitamin and a powerful antioxidant in the . Labdoor analyzed best-selling vitamin C supplements in the United States for vitamin C content and heavy metal (arsenic, cadmium, lea mercury) . Great -tasting, all-natural, pectin-based gummy to support a strong immune system. Vitamin C and Hyaluronic Acid. Besides being a powerful antioxidant, . Oct As a powerful antioxidant, vitamin C contributes to immune defense by supporting the immune system. Powerful -Strength Line-Reducing Concentrate.\nOn a practical level, this means that . Phosphorus supports calcium in building strong bones and teeth. Say goodbye to fine lines and and wrinkles, . Mar What do locally grown potatoes, citrus fruits from the south and tropical mangos have in common? Vegetables and fruit are rich sources of vitamin C. Read on to get the scoop on vitamin C. Absorb the iron from plant foods (such as grains and vegetables). This product presents strong antioxidant. Despite the fact that strong immunostimulatory effects of glucan have been well.\nA mouse study revealed significant healing abilities of a glucan- vitamin C. As an excellent source of the strong antioxidant vitamin C , oranges can also help. The fiber, potassium, vitamin C and choline content in oranges all support . It is often aligned with wound healing because of its role in collagen formation. Tensile strength is important in pressure ulcer healing because healed pressure ulcers are susceptible to future skin breakdown. A lack of vitamin D could keep you from having strong bones and teeth. To give your body the vitamin C it needs, be sure to eat a lot of citrus fruits, cantaloupe, . It promotes the absorption of minerals, helps keep your hair and nails strong , and . Zespri kiwifruit is high in vitamin C , which gives vitality, immunity and skin health.\nKeeping colds away by helping to keep the immune system strong. It is a powerful antioxidant, protecting your body from the damage of free radicals. Apr All of your vitamins are important — vital, even.\nSalespeople will use this fact to try to sell you supplements every day, and their vitamin is . Learn more about ascorbic acid and the best vitamin C food choices. A water- soluble vitamin and powerful antioxidant, it helps the body form and maintain . How vitamin C prevents oxidation. Did you think that ascorbic acid was just a tasty vitamin? Are you one of those individuals who are doing whatever you can just to avoid getting sick?\nA lot of people say that you are better off avoiding getting sick rather. The health benefits of vitamin C are abundant and varie but vitamin C is probably best known as a cell protector, and powerful antioxidant. Including vitamin C -rich foods in recipes with your best iron sources can.", "label": "Yes"}
{"text": "The glycoprotein gp91(phox) is an essential component of the phagocyte NADPH oxidase and is expressed in eosinophils, neutrophils, monocytes, and B- lymphocytes. We previously suggested an eosinophil-specific mechanism of gp91(phox) gene expression. To elucidate the mechanism, we performed functional assays on deletion mutants of the gp91(phox) promoter in various types of gp91(phox)-expressing cells. A 10-base pair (bp) region from bp -105 to -96 of the promoter activated transcription of the gene in eosinophilic cells, but not in neutrophilic, monocytic, or B-lymphocytic cells. A 2-bp mutation introduced into the GATA site spanning bp -101 to -96 (-98GATA site) of the fragment abolished its activity. Gel shift assays using a GATA competitor and specific antibodies demonstrated that both GATA-1 and GATA-2 specifically bound to the -98GATA site with similar affinities. Individual transfection of GATA-1 and GATA-2 into Jurkat cells, which have neither endogenous GATA-1 nor GATA-2, activated the -105/+12 construct in a -98GATA site-dependent manner. Combined transfection of GATA-1 and GATA-2 activated the promoter less than transfection of GATA-1 alone. These results suggest that GATA-1 is an activator and that GATA-2 is a relative competitive inhibitor of GATA-1 in the expression of the gp91(phox) gene in human eosinophils.", "label": "Yes"}
{"text": "What is the best type of media to use for your cell line?\nWhen it comes to culturing cell lines in the laboratory, the type of media you use can have a significant impact on the growth and behavior of your cells. But with so many options on the market, it can be difficult to know which one is best for your particular cell line. In this blog post, we'll take a closer look at the different types of media available and the key considerations to keep in mind when choosing the right one for your experiment.\nBasic types of media:\nSerum-containing media: These are some of the most commonly used types of media in cell culture, as they provide a rich source of nutrients and growth factors. They can be further divided into two categories:\nFetal bovine serum (FBS): This type of serum is obtained from the blood of unborn calves and is a popular choice in many cell culture applications. However, there are concerns about the ethical sourcing of FBS, and it can also introduce variability into your experiments due to the differences between batches.\nAnimal-free media: As the name suggests, these types of media do not contain any animal-derived components and are suitable for use in cultures that require a low level of contaminants. Examples include serum-free media and chemically defined media.\nDefined media: These are media that contain known and specific components, which makes them ideal for reproducibility and predictability in experiments. However, it also means that these media can be more expensive to purchase and prepare.\nChoosing the right media for your cell line:\nWhen selecting a media for your cell line, it is important to keep in mind the specific requirements of your cells, such as pH, temperature, and osmolarity. Some key considerations to keep in mind include:\nCell type: Different cell types have different nutritional requirements, so it's important to choose a media that is specifically formulated for the cells you are working with. For example, some cell lines may require specific growth factors or hormones that are not present in all types of media.\nExperimental goal: The type of experiment you are conducting will also influence your choice of media. For example, if you are trying to maintain the normal growth and behavior of your cells, a serum-containing media may be a good choice. But if you are trying to induce a specific change in your cells, such as differentiation or apoptosis, you may need to use a media that is specifically formulated for that purpose.\nCost and convenience: Lastly, it's important to consider the cost and convenience of the media you choose. Some types of media can be expensive to purchase or prepare, while others may require specialized equipment or facilities to maintain.\nSome notable references to consider :\nHam et al. (2007) In vitro cell culture medium: current trends and future directions. Cytotechnology, vol. 53, pp. 17–24.\nDulbecco and Vogt (1954) A new tissue culture medium. Nature, vol. 173, pp. 943–944.\nEarl E. Glynn et al. (2011) A standardized terminology for describing serum-free and defined culture media and methods for preparing them. Biology of Reproduction, vol. 85, pp. 1619–1624.\nWhen it comes to culturing cell lines in the lab, the type of media you use can have a significant impact on the growth and behavior of your cells. By understanding the basic types of media available, and the key considerations to keep in mind when choosing the right one for your experiment, you'll be well on your way to finding the best media for your cell line.\nIn summary, when it comes to choosing the best type of media for your cell line, there are a few key things to consider. Firstly, it is important to understand the basic types of media available, including serum-containing and defined media. Secondly, it is important to consider the specific requirements of your cells, such as pH, temperature, and osmolarity. And thirdly, you should consider the cost and convenience of the media you choose, as well as your experimental goal.\nOne thing to keep in mind is that there is no one-size-fits-all solution when it comes to media selection. The best type of media for your cell line will depend on a variety of factors, including the cell type you are working with, the specific requirements of your cells, and the goals of your experiment. As a result, it's important to carefully consider all of these factors when making your selection.\nAs a final note, it is also advisable to validate your media choice by comparing results with other known cell lines, and referencing credible sources like the examples I have provided. With the right media selection, you can ensure that your cells grow and behave as they should, giving you reliable and reproducible results in your experiments.\nSo, the next time you are faced with the question of what is the best type of media to use for your cell line, consider the facts, trust in credible sources and trust in your own research. With the right media choice, you will have a better chance to get the results you need.\nI’ll end this with a story…\nOnce upon a time, there was a young researcher named Jane who was determined to find a cure for a rare form of cancer. She had spent years studying the disease and had finally made a breakthrough in her lab, discovering a unique cell line that seemed to hold the key to a cure.\nExcited by her discovery, Jane began culturing the cells in her lab, but soon realized that she was having a hard time keeping them alive. Despite her best efforts, the cells were dying at an alarming rate, and her progress was being hindered.\nFeeling defeated and hopeless, Jane reached out to her colleagues for help. One of them suggested that she try using a different type of media to culture her cells. With nothing to lose, Jane decided to give it a try.\nShe carefully researched different types of media and ultimately decided to use a serum-free, defined media that was specifically formulated for her unique cell line. To her amazement, the cells began to thrive, doubling in number every day.\nOver the next few weeks, Jane watched with tears in her eyes as her cells grew stronger and stronger. She knew that this was the key to finding a cure, and her hard work had finally paid off.\nWith the help of her newly thriving cells, Jane was able to develop a treatment that showed promising results in preclinical trials. Thanks to her persistence and determination, and her willingness to try a different type of media, she was able to bring hope to countless patients and their families affected by this rare form of cancer.\nThe moral of the story is that the type of media you use in cell culture can be crucial for the success of your research, and sometimes, the solution to a problem can be as simple as trying something new. It's important to not to be afraid to try different approaches, and have the willingness to look at things from different perspectives, it can lead to groundbreaking discoveries, and can make all the difference in helping people in need.", "label": "Yes"}
{"text": "The Deerhound is one of the oldest Scottish breeds. He descends from the Celtic greyhound.\nThe Deerhound, also known as the Scottish Deer Dog, is of impressive stature, yet its character is calm and obedient. He is well prepared for cold climates due to his thick coat. Learn more about this breed today.\nDeerhound: the origin of the breed\nThe Deerhound is one of the oldest Scottish breeds. He descends from the Celtic greyhound. The Deerhound was bred by Scottish clans for the chase of wolves and other wildlife. Later, when firearms were used for hunting, the Scottish stag dog became useless.\nHe was threatened with extinction, but Sir Walter Scott and Scottish fashion rescued this breed of dog in the 18th century. In the 19th century, Queen Victoria also had a deerhound as a pet. This breed of dog was able to survive until today.\nPhysical characteristics of the Scottish Deerhound\nThe Scottish deer dog is of a size and well-proportioned, but the head is relatively small.\nThe shoulder height should be at least 76 cm for males, for bitches more than 71 cm. Dogs weigh about 45 kg, bitches bring about 36 kg on the scales.\nThe coat is usually shaded gray, but there are also specimens with reddish or reddish-brown tint, mask and black legs, and black tail. Sometimes these dogs are white on the chest, paws, and tail.\nThe character of the Scottish deer dog\nThe Scottish Deerhound is very loving and obedient, but also relatively independent. He needs his room because even if he behaves quietly in the house, he is an extraordinarily fast runner since he was bred for the hunt.\nCare and other tips\nThe skin and the coat of the Deerhound adapt perfectly to rough landscapes and adverse climatic conditions. Therefore, this breed is best suited for the cold continental climate, high mountains or rugged coastal regions. He is prepared for the cold, but heat is more dangerous for him because the hard skin makes him more susceptible to a heat stroke.\nThe Scottish deer dog has a relatively high life expectancy but needs a lot of space, regular training, and a loving family. He is very muscular and strong and therefore needs a high-protein diet.\nLike most large breeds, it is more susceptible to certain diseases, such as stomach rotation or hip dysplasia. But all these problems can be prevented by regular veterinary check-ups.", "label": "Yes"}
{"text": "I just started to work with the anybody software and I already have a first big problem regarding the standing model from repository 1.1, which drives me around the bend. So I would really appreciate some ideas, in which direction it may go.\nAt the time of, Im working on the alignment of knee prostheses, why I would like to modify just one single knee. For instance, changing the axis of the revolute joint in the knee by changing the respective refnode. Or just hide the femur on one side of the model. But everytime when I make modifications in (e.g. Main.HumanModel.BodyModel.Left.Leg.Seg.Thigh), it assume the changes for both sides Im looking forward to hear from you.", "label": "Yes"}
{"text": "Fasting is back in vogue, and while it helps with weight loss, it has many benefits that have been largely overlooked. Indeed, it is one of the most powerful, yet most underutilized medical therapies available. Fasting is a natural therapy that rejuvenates and regenerates the body. Plus, it’s totally free! When the human organism is provided with the necessary conditions for its functioning, in particular an appropriate diet, environment, activity and psychology, it is possible for it to maintain optimal health. If these conditions are not met, health will be compromised. Often the best way to facilitate the restoration of health is through therapeutic fasting. It allows the body to create a unique and unparalleled healing physiological response. So what is therapeutic fasting? What are these health benefits? Is it an effective solution to lose weight naturally?\nWhat is therapeutic fasting?\nTherapeutic fasting is defined as complete abstinence from all substances, except pure water, in an environment of complete rest. Starvation, even for a few days, while working, exercising, worrying, etc. is not therapeutic fasting. A noisy, very stressful and unfavorable environment will not give the organism the possibility of maximizing self-healing mechanisms. To maximize the benefits of therapeutic fasting, complete rest is essential and stressful situations should be avoided. Eating only certain foods or drinking juices is not therapeutic fasting. The impact as well as the physiological and clinical benefits are different. This is not to say that juice fasting diets or so-called elimination diets do not have positive effects. They are simply not the same as therapeutic fasting. When properly applied and conducted, therapeutic fasting is one of the most powerful tools available to help the body heal itself. When abused or applied inappropriately, it can be harmful.\nThe benefits of therapeutic fasting\nIf therapeutic fasting is so recommended, it is because of its many positive effects on the human body.\nWhen the body enters a state of therapeutic fasting, the remaining carbohydrates are depleted. The body will then switch to fat burning. At the same time, the metabolic rate increases instead of decreasing as it does in a state of calorie restriction (low calorie diets). This leads to weight loss.\nThe release of energy\nIn fact, up to 50% of our energy is needed to digest food. In no time, this energy is released from the digestive process and can now be used to heal and regenerate. The body knows better than anyone where healing is most needed.\nAfter 24-36 hours, the diseased and weakened cells will, through processes called apoptosis and autophagy, be driven into cell death, dismantled and recycled into new cells. However, there is nothing to worry about because it is a completely natural process. An average human adult loses between 50 and 70 billion cells every day through apoptosis. This rate is greatly increased by therapeutic fasting.\nStem cell regeneration\nThe next step in the therapeutic fasting process is the significant increase in stem cell production and activation. The number of new stem cells and the level of human growth hormone increase dramatically during days 3 to 5 of the fast, then decrease again thereafter. More recent research has shown that during this period of increased stem cell production, a huge amount of new white blood cells are produced, which strengthens the immune system.\nImproving the immune system\nHave you ever noticed that when animals get sick, they stop eating? Have you ever wondered why this happens? It is a natural instinct by which animals try to reduce stress on their internal system and focus their energy on fighting infection. So the next time you get sick, resist the temptation to forage for food and focus on fasting instead.\nBreaking the fast with fruit can boost your immune system even further by providing your body with a source of essential vitamins and minerals, especially vitamins A and E which are great antioxidants. Fasting also prevents the formation of cancerous cells, regulates the likelihood of inflammation, and helps reduce the occurrence of free radicals in the body that cause damage to cells, DNA, and proteins in the body, thus contributing to the evolution of the disease. Remember, fasting triggers the regeneration of old cells in the body. This rejuvenation of cells results in improved immune function. According to a study, a three-day fast can lead to the regeneration of the entire immune system and the production of totally new white blood cells that have a greater ability to fight disease.\nOther Benefits of Therapeutic Fasting\nAlong with burning fat, losing weight, and boosting the immune system, therapeutic fasting has many other health benefits. It reduces inflammation, rebalances the gut microbiome and hormones, protects the brain against harmful changes associated with Alzheimer’s, Parkinson’s and other neurological diseases. It reduces the risk of cancer and the rate of aging but also regulates cell maintenance and repair processes.\nIn which cases should therapeutic fasting be avoided?\nThere are people who are not good candidates for therapeutic fasting. However, there are few conditions that contraindicate its proper use. The biggest contraindication is fear. A lack of understanding of the process of fasting can present serious problems. Extreme weakness caused by various illnesses and associated with muscle atrophy can also interfere with therapeutic fasting. There are also many medications that can complicate the fasting process. Insufficient nutrient stores would also be another potential contraindication to fasting. Certain types of cancer and serious kidney disease may also make an individual a poor candidate for therapeutic fasting. So, seek advice from a specialist before starting therapeutic fasting. Given all these benefits, it seems obvious that therapeutic fasting is a great way to lose weight naturally and stay in good shape. But be careful to respect the conditions required to practice it, at the risk of damaging your health.", "label": "Yes"}
{"text": "The School of Biotechnology was set up in 2006 from the earlier Center for Biotechnology. BioSpectrum magazine rated the Bio Technology program of JNU as third ranking institute among all public schools in India. (Source: Wikipedia)\nBiotechnology is a multidisciplinary area on the educational scene and programmes have been developed to meet the growing demand for trained manpower for any meaningful biotechnology activity in the country. The programmes are designed to expose the students to recent exciting developments in the area of genetic engineering and biotechnology and their exploitations in industry, agriculture and medicine.\nJNU holds a Combined Entrance Examination for admission to two-year MSc programme in Biotechnology on behalf of various participating universities. For intake details for those universities, click here (Source: Official Prospectus)\nAndragogy offers programmes for the JNU (CEEB) entrance examination.\nFor other details, click here", "label": "Yes"}
{"text": "It's a guinea pig with sneeze and crusty nose, Theo and Ron.\nIt's a guinea pig with sneeze and crusty noseJA: I'm sorry to hear that. What is the guinea pig's name and age?Customer: Theo and Ron. We just got them two weeks ago from pet store.JA: How old is Theo?Customer: Probably 8-10 weeks?JA: Is there anything else the Veterinarian should be aware of about Theo?Customer: He ate some duct tape the other day.JA: The Veterinarian will know if Theo will be able to digest that. OK. Got it. I'm sending you to a secure page on JustAnswer so you can place the $5 fully-refundable deposit now. While you're filling out that form, I'll tell the Veterinarian about your situation and then connect you two.Customer: But the sneezing was before that\nVeterinarian and practice owner\nHello,We are very concerned about our 6-year old mixed\nHello, We are very concerned about our 6-year old mixed breed dog. He has had a wide range of chronic and acute health problems that we feel might be suggestive of an immune disorder. We would like to hear your thoughts and more specifically, to identify whatever tests would be appropriate to definitively determine what is going on with him. Health history: Very sick puppy, from 3-6+ months. Rescued from shelter during an outbreak of distemper. His symptoms were difficult to distinguish – between severe URI or distemper. Treated with an experimental distemper treatment, he survived. We will never know if vet’s “cure” succeeded, or it was an unidentified respiratory illness Tested positive for Lyme about 4 years ago and was treated with antibiotics. Had swollen joints. Had two TPLOs for CCL injuries about a year apart. The last was about 1 year ago. He healed very well from both, but from time to time, favors or limps on a leg for a day or a few days and recovers. Prone to ear infections; has had several eye infections. Had neither in last year. He has a mild heart murmur About 3 years ago, began to suffer from skin problems – initially hot spots, then a mildly crusty nose and secondary sores/infections, primarily yeast infections. Two years ago, this was diagnosed as allergies and he was/is treated with allergy shots to desensitize him. He showed modest improvement the next summer. Recent/current issues: He developed depigmentation on his nose at nostril, lips and inside his mouth over the last 1-2 years About 6-8 months ago, developed small bald patches (from the size of a dime to the size of a nickel) on his back and sides. Diagnosed as pyoderma and successfully treated with antibiotics. A few months later, about 3 months ago, his abdomen and groin were very irritated, itchy and seemed to have a yeast infection. At the same time, we noticed slight urinary incontinence that we/vet thought was contributing to this – he was leaving very small wet spots when resting. He did not have a UTI and we started him on PPA and chlorhexadine baths for the yeast infection. Within days after the yeast infection above, he suddenly developed a very foul, fishy smell and his groin/stomach appeared much worse. He also had a fever. We brought him into the vet and he was hospitalized overnight. He was diagnosed with severe bacterial infections of about 10 different bacteria, including several antibiotic resistant strains. He took several different antibiotics, continued on the PPA and recovered. About a month ago, one lower rear leg became swollen at and above the ankle. (It was not the joint, but rather a fluidy edema-type swelling.) He also had a red, raised lesion on the knee. He also had another flare up of various skin infections on groin, abs and his tail with fever again. His crusty nose became much worse, his eyes were rheumy and irritated and his tongues strangely slimy and bright red. He seemed extremely ill. We took him into emergency, and he was started on two different antibiotics and an antifungal. The lesion was biopsied/removed and we were told it is a histiocytoma. An x-ray showed inflammation inside his leg was causing the swelling, but the orthopedist said he did not think it was an infection of the TPLO. Blood tests showed some anemia and his urine was slightly dilute. His skin infections improved over the course of the antibiotics, but his crusty nose and eyes did not. He also remained lethargic, and developed new symptoms: heavy, foamy drooling and licking the air and oddly “chomping” at food when eating, like he had mouth pain or difficulty swallowing. Vet advised us to discontinue antibiotics and antifungals. The only change since doing so is a little less lethargy. He appears to have lost weight and muscle mass. His leg still swells on and off Increased thirst; heavy water drinking – ½ a bowl at a sitting Increased appetite We take our dog to a large veterinary hospital and find he has been bounced from specialist to specialist so much that nobody has really taken all of his symptoms into account. No further testing at all has been done to try to get to the root of why our dog has such continual ill health and see if there is an underlying cause. The dermatologist took the lead on his care and just feels it is an allergy and argues that is enough of an explanation for everything. We obviously worry it might be lupus or a similar immune disease. If you wanted to do a completely exhaustive, definitive series of tests to either confirm or rule out – EVERY test that you would think to run -- what would they be? On Monday we are taking him to an internal medicine vet and want to make sure we are completely armed with information. Thank you so much for your help. Susan\nDoctor of Veterinary Medicine\nMy ten yr old Yorkshire became ill with pancreatitis abt three\nMy ten yr old Yorkshire became ill with pancreatitis abt three months ago. He has returned to fairly good health, but I am worried about the crusty nose he developed while sick. It looks sore and by touch it's hard and seems to be tender. My vet tell me that they have no idea what causes this and not to worry. However, it has an appearance of eroding away-- almost as though it will drop off if it continues.His nose has been runny since becoming ill.Virginia Meeker\nborder collie: my 10 year..10 year old..treated her for years..oxide\nmy 10 year old border collie has always had a skinned looking nose, for about six months she has had a sore crusty nose. I have treated her for years with zinc oxide and recently started using vetericyn.when it became hard and crusty. Its been about two weeks and it is still crusty but now has started to peel off to a raw red skin underneath. I have a feeling that it is a cancer, but was hoping it could be treated anyway..", "label": "Yes"}
{"text": "What people are saying - Write a review\nWe haven't found any reviews in the usual places.\nBleeding in the First Trimester\n5 other sections not shown\nabnormal abortion abscess acoustic texture amniotic fluid anatomic approximately ascites attenuation biparietal diameter bowel loops cephalad cervical region cervix clinical cul-de-sac cystic demonstrates dermoid diagnosis diagnostic ultrasound echo pattern echoes arising echoes arrows echogenic echogenic mass ectopic pregnancy embryo endocervical canal endometriosis fetal abdomen fetal body fetal head fetal skull fetal spine fetus fibroid Figure fluid-filled fundus gestational sac highly echogenic Iliopsoas muscle incompetent cervix indentation interface intrauterine device kidney left ovary lesion linear echo liver longitudinal scan lower uterine segment lucent M. D. Anderson Hospital menstrual week molar pregnancy myoma myometrial myometrium normal ovarian cyst ovary patient pelvic inflammatory disease pelvic mass piriform muscle placenta previa polyhydramnios portion posterior placenta present real-time reverberation scan fig secondary seen situated sonolucent mass sound beam structures surrounding echoes symphysis pubis tion transducer transverse scan tudinal scan tumor ultra ultrasonic appearance ultrasonography ultrasound examination urinary bladder usually uterus velocity changes ventricles visualized", "label": "Yes"}
{"text": "There are several possible reasons why your tooth tastes weird. One of the most common causes is an infection caused by discharge from an abscess that empties in your mouth or an infection in your gum or jawbone.\nIf the infection is still at its early stage, the bad taste typically isn’t accompanied by pain. For that reason, you may notice a weird taste for days, weeks, or months before you start to feel pain. By the time you feel pain in the tooth, the infection has already spread, and the bacteria may already be in your circulatory system. That’s why we recommend our patients to always see one of our dentists at Kane & Kerper Family & Cosmetic Dentistry each time they feel something is awry in their mouth or teeth.\nThe bad taste that you experience may vary. Some of our patients would describe it as bitter or sour while others would consider it as merely unpleasant. If you notice that your tooth tastes weird, you should talk to your dentist immediately. It could be the result of a potential infection that might lead to oral decay. It could also be halitosis.\nPoorly Maintained Fillings\nAnother reason your tooth tastes weird is that you have bad dental fillings, especially if they’re falling apart and causing a metallic taste. Even if you have silver mercury fillings, which are known to be a durable filling material, they could still erode. If that happens, bacteria in your mouth could travel into your tooth, causing a bad odor or taste in your mouth.\nIf the problem is left untreated, it could cause tooth decay and might result in tooth extraction. You should contact your dentist immediately if you start to feel that your tooth tastes weird. If it’s the result of a failing dental filling, it could be replaced without resorting to tooth extraction. If you wait a little longer, the bacteria inside the affected tooth will cause further damage and the only option to remedy the situation is extraction. To save it, a root canal therapy may be suggested.\nOther reasons why your tooth tastes weird:\nPoor oral hygiene. If you failed to brush and floss regularly, you will soon suffer from gingivitis and a possible tooth infection. Your dentist might recommend a prescription medicine to get rid of the infection. When it’s healed, the weird taste in your tooth goes away.\nPrescription drugs. Antibiotics, gout medicine, and cardiac drugs are some of the prescription medications that could affect your taste and taste buds. Apart from prescription medicines, some over the counter vitamins might also be the reason your tooth tastes weird. Multivitamins with copper, zinc and other heavy metals can cause a metallic taste.\nIf you experience a weird odor in your mouth or tooth, it’s best to consult with your dentist. He’ll examine your mouth to know whether or not you’re suffering from tooth decay. He can also refer you to a dentist if you have a serious medical condition.", "label": "Yes"}
{"text": "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG\nAbbreviated Journal Title\nprostate cancer; dihydrotestosterone; transcription repressors; SREBP; SNAIL; growth factor; ACID SYNTHASE EXPRESSION; REPRESSES E-CADHERIN; SERINE-PROTEASE; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; SNAIL; CELLS; RECEPTOR; LOCALIZATION; ACTIVATION; Endocrinology & Metabolism; Urology & Nephrology\nBACKGROUND. Prostasin is downregulated in hormone-refractory prostate cancers (HRPC). The mechanisms by which androgens regulate prostasin expression are unclear. METHODS. LNCaP cells were treated with dihydrotestosterone (DHT), and mRNA expression of prostasin, SREBPs, SNAIL, and SLUG was examined by real-time PCR following reverse transcription. A human prostasin promoter was evaluated in HEK-293 cells cotransfected with transcription factor cDNAs. Regulation of endogenous prostasin expression by transfected SREBP-2 or SLUG was evaluated. Expression of SNAIL and SLUG mRNA in DU-145 cells treated with epidermal growth factor (EGF) was examined. RESULTS. Prostasin mRNA expression in LNCaP cells was not responsive to DHT treatment. DHT marginally upregulated mRNA expression of SREBP-1c, SREBP-2, and SNAIL, but not SREBP-la, while dramatically increased SLUG mRNA expression, in a dose-dependent manner. Co-transfection of prostasin promoter and SREBP cDNA in HEK-293 cells resulted in stimulation of promoter activity at similar to twofold by SREBP-1c, and up to sixfold by SREBP-2; while co-transfection with SNAIL or SLUG cDNA resulted in repression of promoter activity to 43% or 59%, respectively. Co-transfection of the SLUG cDNA negated SREBP-2's stimulation of prostasin promoter in a dose-dependent manner. Transfection of an SREBP-2 cDNA in HEK-293 and DU-145 resulted in upregulation of prostasin while transfection of a SLUG cDNA in LNCaP repressed prostasin expression. EGF upregulated SNAIL and SLUG mRNA in DU-145. CONCLUSIONS. DHT regulates prostasin expression in prostate cells via SREBP stimulation and SLUG repression of prostasin promoter. SLUG is upregulated by DHT and EGF, providing a molecular mechanism by which epithelial cell-specific genes are silenced during prostate cancer development and progression.\n\"Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG\" (2006). Faculty Bibliography 2000s. 4667.", "label": "Yes"}
{"text": "Cancer Research jobs in Full Time\nBroaden your search\nRefine your search\nFound 4 Senior Scientist, Employer jobs\nThe Winter laboratory at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, is recruiting a synthetic ...\nIdentify quantitative principles in cancer to navigate in disease complexity, guide therapeutic interventions with model data&computational approaches\nStructural Biology/X-ray Crystallography position at the VCU Massey Cancer Center Senior Research Scientist position in Structural Biology/X-ray Cr...\nBioinformatics/Drug Discovery position at the VCU Massey Cancer Center Senior Research Scientist position in Bioinformatics/Drug Discovery in the c...", "label": "Yes"}
{"text": "|Author:||El-Sabbagh, A. A. ; Abd El-Hafez, S. A. ; El-Bably, A. Z. ; Abou-Ahmed, E. I.|\n|Book Group Author:||NA|\nA field experiment was conducted in Kafr El-Sheikh Governorate, Egypt, during 2004 and 2005 to study the effects of irrigation after 40, 60 or 80% of the available soil moisture had been depleted on the productivity and water relations of soyabean cultivars Giza 21, Giza 35 and Crawford. Plant height, number of pods per plant, 100-seed weight, seed yield per plant, seed oil content, and seed, straw, biological, oil and protein yields significantly decreased, whereas the seed protein content increased as the level of soil moisture depletion increased. Giza 21 was superior in plant height (77.21 cm), number of pods per plant (51.63), 100-seed weight (15.39 g), seed yield per plant (12.03 g), straw yield (2570 kg/feddan), biological yield (3748 kg/feddan), oil yield (21.85%), oil yield (272.08 kg/feddan), protein yield (428.27 kg/feddan) and water use efficiency (23.60 kg seed yield/cm of water consumed), except seed oil and protein contents, for which Crawford (22.24%) and Giza 35 (34.92%) were superior, respectively. Water requirement values were 75.48, 68.40 and 55.60 cm for irrigation after the depletion of 40, 60 and 80% of the available soil moisture, respectively. The seasonal water consumptive use values increased as the available soil moisture increased in the root zone. The cultivar had no significant effect on water consumption. The highest values of water use and utilization efficiencies were recorded for the irrigation after the depletion of 60% of the available soil moisture. Seasonal water use was positively associated with seed, straw, biological, oil and protein yields, and water use efficiency. [1 feddan=0.42 ha].\n|Pages:||571 - 586|\n|Journal:||Bulletin of Faculty of Agriculture, Cairo University|\nchemical composition, crop yield, cultivars, irrigation,plant composition, plant height, plant water relations, pods, proteincontent, seed weight, seeds, soil water, soyabeans, varietal reactions,water deficit, water use efficiency, yield components, Egypt, Glycine(Fabaceae), Glycine max, North Africa, Africa, Mediterranean Region,Middle East, Developing Countries, Glycine (Fabaceae), Papilionoideae,Fabaceae, Fabales, dicotyledons, angiosperms, Spermatophyta, plants,eukaryotes, chemical constituents of plants, cultivated varieties, soilmoisture, soybeans, watering, Field Crops (FF005) (New March 2000),Plant Breeding and Genetics (FF020), Plant Water Relations (FF062),Plant Production (FF100), Fertilizers and other Amendments (JJ700)", "label": "Yes"}
{"text": "Diabetes: Are Nuts Good for me?\nComplete knowledge of 'Nuts' for diabetes\nYou must have heard this many a time - 'Are you nuts?'... a common phrase used to ask if one is crazy.\nBut have you ever thought why only nuts and nothing else?\nIt must be due to the characteristic roughness of the outer shell of nuts.\nwhat is a nut?\nA nut is a fruit consisting of a hard nutshell protecting a kernel which is usually edible. In general usage and a culinary sense, a wide variety of dry seeds are called nuts, but in a botanical context \"nut\" implies that the shell does not open to release the seed.\nInteresting History of nuts\n- From old Anglo-Saxon literature to religious texts, nuts have been documented as sources of nutrition throughout history.\n- Almonds and pistachios are mentioned by name in the bible, while other nuts can be found in works of Shakespeare.\n- Nuts have been proven to be quality Sources of Proteins and healthy fats and are key drivers in weight loss.\n- Many historians also believe modern agriculture began with the harvesting and storage of nuts.\nBecause of their predictable growth patterns and long storage life, nuts were the ideal crop for early civilizations.\n- All of this evidence shows that nuts have been a staple in the human diet since the beginning of history.\nNuts and Diabetes\n- There is a definite link between nuts and diabetes. Nuts play a crucial role in diabetes reversal.\n- To explain logically, the main factor resulting in diabetes is Insulin Resistance.\n- Insulin resistance is mainly caused due to acid and inflammation present in our body and nuts help in reducing acid and inflammation in our body.\n- Amongst all the available nuts, almonds and walnuts are typically helpful in diabetes reversal. As compared to peanuts, pistachio, cashew, hazelnuts, and brazil nuts, almonds and walnuts have more alkanility.\n- So they are very helpful in the process of reversal and are largely used for the same\nBenefits of nuts\n- Nuts are nutrient-dense food rich in fats and protein.\n- They contain high-quality vegetable protein, unsaturated fatty acids, dietary fiber, phytosterols, and phenolic compounds.\n- They also contain vitamins like tocopherols, folic acid, niacin, B6, and minerals like calcium and magnesium.\n- Having them significantly reduces the incidence of heart disease, hypertension, cancer, and inflammation.\n- They are very good for blood circulation.\n- Having nuts in a controlled proportion can help with diabetes and insulin sensitivity.\nIn a life that is quite stressful and active, there are a lot of free radicals in your body as well as oxidative stress which produces a lot of inflammation. So to counteract this, nuts are very good. The most people miss about nuts is to soak them.\nWhy soak nuts?\n- Nuts have phytic acid which binds to the minerals in the gastrointestinal tract thus hampering the absorption of minerals. By soaking nuts you break down the phytic acid so that minerals can be easily absorbed.\n- Nuts also have high amounts of enzyme inhibitors making them hard to digest. Soaking nuts can neutralize the enzymes allowing their proper digestion. Brown peel of almond contains tannin which can inhibit nutrient absorption. Hence soak them, remove the peel and have them. Do not expose the peeled nuts for a long period is the only thing one has to keep in mind.\nHow much time should the nuts be soaked?\nThe nuts should be soaked for 7 hours or overnight with salt and water. Water will increase the bioavailability of many nutrients, especially B-vitamins. Salt helps activate enzymes that deactivate the enzyme inhibitors present in the nuts.\nWhat is the ideal time to have nuts?\nAn ideal time for nut consumption is the evening time because it is the time when you consume an unhealthy snack. Instead of munching something unhealthy one can have nuts. Soaked nuts work as a good hunger suppressant and also have low GI.\nHow much quantity to eat?\n- 4-5 soaked almonds and 2 soaked walnuts\n- 8 cashew nuts once in a week\n- 8-10 pistachios once in 10 days\n- 10-15 soaked peanuts twice a week\nInclude nuts in your diet regime and see the difference! Did you find this blog to be interesting? We would know your feedback. Also, do let us know which other topic about diabetes-friendly foods you want us to cover in the future.\nThis Blog solely serves our marketing purposes, for Authentic knowledge for this topic, Please join our upcoming Discover Reversal Session", "label": "Yes"}
{"text": "Electroencephalography (EEG) is the measurement of electric potentials at the scalp due to currents flowing through scalp tissue.\nThe strength and distribution of currents (and therefore potentials) reflects the intensity and position of activity in the underlying neural tissue.\nEEG signal is measured between two electrodes, the position of which determines the recorded brain area. Multiple electrodes are typically placed in standard\narrangements that cover the entire scalp and allow investigators to observe the activity of the entire brain simultaneously.\nEEG is typically recorded as a time-series of potential differences, which can be evaluated visually, or analyzed spectrally,\nor through the use of source localization methods. The principal spectral components of EEG are divided into the following signal bands:\ndelta (0-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (above 12 Hz) and gamma (above 40 Hz). Many studies have related changes in various spectral components\nof EEG to specific cognitive functions and clinical conditions.\nIn clinical settings, continuous EEG recordings are used for monitoring sleep and anesthesia, and diagnosis of epilepsy, coma, brain death, and more recently ADHD.\nIn research environments, EEG recordings are used in wide range of applications, including: neuroscience and cognitive psychology research into understanding brain function;\nBrain-Computer Interfaces to allow control of computers or machines from neural signals; neurofeedback where users are able to train their brains to generate specific activity\npatterns; neuromarketing where marketing companies seek to tap directly into brain signals to assess subjects’ engagement levels; neuroergonomics where researchers quantify mental\nworkload under various strains; gaming where EEG signals are used to control computer games and toys; etc.\nCheck out Wikipedia's entry on EEG for a more detailed introduction to EEG.\nEEG Spectral Components\n© 2017 SCIENCE IN MOTION . All Rights Reserved | Design by W3layouts", "label": "Yes"}
{"text": "In Kazakhstan, scientists have found clues to what may be causing a massive die-off of a severely endangered species of antelope.\nVideos by Rare\nNBC News reports that in May, geoecologist Steffen Zuther arrived at the steppes of central Kazakhstan to monitor a herd of saigas to learn that veterinarians had already found dead animals on the ground. While that was not necessarily cause for alarm, four days later, the entire herd of 60,000 had died. Similar crashes followed through early June, taking more than half of the country’s herd, which numbered 257,000 as of last year.\n“The extent of this die-off, and the speed it had, by spreading throughout the whole calving herd and killing all the animals, this has not been observed for any other species,” Zuther said. “It’s really unheard of.”\nSaigas are native to Kazakhstan, with smaller herds in Russia and Mongolia. The die-off started during the calving period. Workers took samples of the soil, rocks, water and plants in the area, and conducted necropsies on the animals. The females, they found, were the first to die, followed by the calves, which led researchers to believe the disease was transmitted through milk.\nTissue samples showed internal bleeding caused by bacterial toxins that typically don’t bother saigas unless they have immune issues. An environmental factor or some other natural variance may be at work, but Zuther said there’s no conclusion yet.\nThe saiga suffered large losses in the 1990s due to poaching, according to the Associated Press.", "label": "Yes"}
{"text": "The cause of missing eyes can be either high incubator temperature or low oxygen some time from day 1 thru 6 of incubation - or both.\nWow!!!!! 163!!! How gorgeous. Would love to see a pic.\nWe had two hatch last year that were one eyed monsters. Missing eye on one side like yours and the other side had a massive bulging eye. They also had bad cross beaks. Ended up culling them as they couldn't eat or drink on their own. After 3 days of hand feeding with no improvement in independence we decided to cull.\nThanks for the pics. How gorgeous they all are. Most we have ever had at one time has been 17 quail and 17 chickens, not at the same time though. We only have a small incubator though, which only fits 24 chicken eggs and supposedly 60-70 quail eggs, but it didn't come with enough dividers to fit that many quail eggs in order to allow for the rolling. Have had up to 56 quail eggs in there though, but had a very poor hatch rate as they were shipped eggs and a lot weren't even fertile.", "label": "Yes"}
{"text": "B-Raf inhibitor 1 dihydrochloride\nB-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116 .\nB-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model [1, 2].\n Wang X, Kim J. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41.\n Smith AL, DeMorin FF, Paras NA, Huang Q, Petkus JK, Doherty EM, Nixey T, Kim JL, Whittington DA, Epstein LF, Lee MR, Rose MJ, Babij C, Fernando M, Hess K, Le Q, Beltran P, Carnahan J. Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. J Med Chem. 2009 Oct 22;52(20):6189-92.\n|Storage||Store at -20°C|\n|Solubility||Soluble in DMSO|\n|Shipping Condition||Evaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request|\n|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|\n|Description||B-Raf inhibitor 1 dihydrochloride is a potent and selective inhibitor of B-Raf with IC50 values of 0.31 μM and 2 nM for A375 proliferation and A375 p-ERK, respectively.|\n|Targets||A375 proliferation||A375 p-ERK|\n|IC50||0.31 μM||2 nM|", "label": "Yes"}
{"text": "C.K.L.P. Batista, G.A.C. Brito, M.L.P. Souza, B.T.A. Leitão, F.Q. Cunha and R.A. Ribeiro. A model of hemorrhagic cystitis induced with acrolein in mice. Braz J Med Biol Res 2006; 39: 1475-1481.\nFigure 2. Dose-dependent increase in bladder wet weight and Evans blue extravasation induced by intravesically administered acrolein (ACR). Bladder wet weight (A) and Evans blue extravasation (B), in untreated animals (C, control) and in animals injected intravesically 3 h earlier with acrolein (25, 75, 225 µg/bladder). Data are reported as means ± SEM (N = 6). *P < 0.05 compared with control (C) (ANOVA and Bonferroni test).", "label": "Yes"}
{"text": "There are several types of angioedema, a disease marked by swelling underneath the skin and/or in mucus membranes.\nThe different angioedema types are distinguished mainly by their underlying cause. Some forms are triggered by allergic reactions, while others occur due to genetic mutations, a malfunction of the immune system, or as a side effect of certain medications.\nDuring an allergic reaction, the body’s immune system mistakenly recognizes a harmless external substance as a potential threat. These substances may include foods (e.g., eggs, nuts, shellfish, milk), medications such as nonsteroidal anti-inflammatory drugs (e.g., aspirin) or certain antibiotics (e.g., penicillin), or latex.\nWhen this happens, immune cells release an inflammatory signaling molecule called histamine which, among other effects, dilates blood vessels and increases their permeability, which can trigger swelling.\nSwelling in acute allergic angioedema usually sets in within an hour of exposure to the allergen, the substance causing the allergic reaction, and it may last a day or two without treatment. Symptoms such as hives and itching are generally more common in this acute angioedema form than in other types of the disease.\nHAE-causing mutations usually are inherited from an individual’s biological parents, though in rarer cases they can arise spontaneously in people who don’t have a family history of the condition. HAE is a dominant genetic disorder, meaning that a single faulty gene copy is sufficient to trigger its onset. HAE affects people of all sexes and races equally.\nThis type of angioedema generally manifests during childhood or early adulthood in the form of recurrent swelling attacks or episodes of abdominal pain that can last a few days. HAE attacks may be preceded by early signs — what’s called prodromal symptoms — that may include fatigue, muscle aches, and a kind of rash that’s not itchy called erythema marginatum. Unlike other forms of angioedema associated with allergic reactions, HAE is rarely accompanied by hives or itching.\nHAE is divided into different types based on the specific disease-causing mutation a person carries. The most common, known as HAE types 1 and 2, are both caused by mutations in the SERPING1 gene, which provides instructions for making a protein called C1 esterase inhibitor (C1-INH).\nThe resulting deficiency in C1-INH activity leads to the excess production of a signaling molecule called bradykinin, which triggers swelling attacks.\nHAE type 1\nWhile HAE types 1 and 2 are both caused by mutations in the same gene, the consequences of those mutations on the C1-INH protein are distinct in each type. In HAE type 1, mutations in the SERPING1 gene impair protein production, causing the levels of C1-INH protein to dip too low. This is the most common form of HAE, accounting for 80% to 85% of all cases.\nHAE type 2\nHAE type 2 accounts for about 15% to 20% of all HAE cases. In contrast to HAE type 1, C1-INH levels are normal in HAE type 2, but the protein itself is faulty and unable to function properly, which also leads to reduced C1-INH activity.\nHAE type 3\nHAE type 3, sometimes called normal-C1-INH HAE, broadly encompasses all cases of HAE caused by mutations in genes other than SERPING1. These forms of HAE are much rarer than types 1 and 2, and aren’t so well understood. Unlike the two former types, C1-INH levels and activity are both normal in HAE type 3, and patients can only be diagnosed with genetic tests.\nSome cases of HAE type 3 are associated with mutations in a gene called F12, which provides instructions for making a protein called coagulation factor 12 that normally helps produce bradykinin. HAE-associated mutations cause this protein to be overactive, increasing bradykinin levels and triggering swelling. HAE associated with F12 mutations predominantly affects women, though there also have been documented cases of male patients with this form of HAE.\nOther cases of HAE type 3 may be associated with mutations in other genes, such as PLG and ANGPT1, but these remain incompletely understood.\nNonallergic angioedema, also known as drug-induced angioedema, refers to swelling that occurs as a side effect of certain medications.\nThis type of angioedema is most commonly associated with angiotensin-converting enzyme (ACE) inhibitors, a class of medications that are commonly used to lower blood pressure but also can increase the levels of bradykinin.\nAngioedema affects up to 2.5% of patients taking ACE inhibitors, and is more common among those of African descent. Patients taking ACE inhibitors should be aware of this potential risk, especially because swelling in the throat can block the airways and impair breathing, requiring immediate medical attention.\nIn rarer cases, nonallergic angioedema also may be associated with angiotensin receptor blockers, a class of medicines frequently used to treat high blood pressure. These medications include losartan (marketed as Cozaar and others) and valsartan (marketed as Diovan, among other brand names).\nAngioedema symptoms generally manifest in the first weeks or months of treatment with the medication that triggers the condition, although they may arise much later. There is no specific diagnostic test to confirm the presence of this type of angioedema. Suspicion may be triggered if a patient shows signs of the condition and is known to have been taking medications that can cause angioedema as a side effect. In such cases, discontinuing treatment with that drug is recommended.\nIdiopathic angioedema is a form of angioedema that lacks a specific known cause. This type of angioedema is diagnosed when a person experiences recurrent or chronic episodes of swelling, and all other possible angioedema causes have been ruled out. In up to half of the cases, idiopathic angioedema occurs in people with underlying autoimmune disorders, such as lupus.\nMost people diagnosed with this disease form experience symptoms similar to those of allergy-related angioedema, where swelling is accompanied by other symptoms such as itching or hives and responds well to treatment with antihistamines. In rarer cases, idiopathic angioedema may be driven by bradykinin with symptoms similar to those of HAE.\nAcquired angioedema (AAE) is similar to HAE type 1 in that it is marked by abnormally low levels of the C1-INH protein. But unlike HAE, where low C1-INH levels are caused by a genetic mutation that’s present from birth, AAE is marked by low C1-INH levels due to a condition that develops during a person’s lifetime. This type of angioedema is about 10 times rarer than HAE, with estimates indicating it may affect 1 out of every 100,000 to 500,000 people.\nAAE can be divided into two subtypes, depending on its specific cause:\nType 1 AAE develops in people with underlying disorders where immune cells grow excessively (lymphoproliferative disorders), including some autoimmune diseases and cancers. The abnormal growth of these immune cells leads to the irregular activation of certain inflammatory proteins, including C1 — a protein that, as its name suggests, is normally inhibited by C1-INH. As the body tries to regulate C1 levels, C1-INH is spent, ultimately leading to abnormally low C1-INH levels and swelling.\nType 2 AAE occurs as a result of an autoimmune disorder where the body’s immune system mistakes the C1-INH protein for an infectious threat and makes antibodies against it. This autoimmune attack ultimately prevents C1-INH from working as intended, setting the stage for swelling attacks.\nAngioedema vs. hives\nAngioedema and hives are forms of skin swelling. While angioedema is characterized by swelling in the deeper layers of the the skin, hives are marked by swelling that occurs in the superficial layers of the skin.\nAngioedema and hives can co-occur in some cases and the presence or absence of hives in people with angioedema can be helpful in identifying the specific angioedema type a person has. For instance, hives commonly affect people experiencing forms of angioedema associated with allergies, but are comparatively rare in people with HAE.\nIn hives, also referred to as urticaria, swelling manifests in the form of circular, oval, or worm-like shape wheals of varying sizes on the surface of the skin. The affected areas are usually darker than the surrounding skin; on people with paler skin, hives typically appear pink or reddish, whereas in dark-skinned individuals they may look deep red or purple. A telltale sign of hives is that they are almost always itchy.\nBy contrast, swelling from angioedema is generally less defined than swelling from hives. Angioedema alone usually doesn’t cause dramatic skin discoloration or substantial itching, though areas affected by angioedema may feel warm, tender, or painful.\nAngioedema News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.", "label": "Yes"}
{"text": "Spontaneous fluctuations in the electrical signals of the retina's photoreceptors impose a fundamental limit on visual sensitivity. While noise in the rods has been studied extensively, relatively little is known about the noise of cones. We show that the origin of the dark noise in salamander cones varies with cone type. Most of the noise in long wavelength-sensitive (L) cones arose from spontaneous activation of the photopigment, which is a million-fold less stable than the rod photopigment rhodopsin. Most of the noise in short wavelength-sensitive (S) cones arose in a later stage of the transduction cascade, as the photopigment was relatively stable. Spontaneous pigment activation effectively light adapted L cones in darkness, causing them to have a smaller and briefer dim flash response than S cones.", "label": "Yes"}
{"text": "Dr. Mohan’s Diabetes conducts a walkathon in Tambaram on the\noccasion of World Hypertension Day\nIndia’s leading hospital in the field of Diabetology, Dr. Mohan’s Diabetes\nSpecialities Centre conducted a walkathon at their Tambaram Centre. With around 100 participants\nfrom the public and their team, the one kilometre walkathon was held from Tambaram clinic to\nTambaram Velachery main road (UCCO BANK). Dr. Prasanna Kumar Gupta and Dr.J. Selva Kumar – Senior Consultants at Dr. Mohan’s Diabetes Specialties Centre – Tambaram branch flagged off the\nevent and briefly spoke about the prevention and control of hypertension along with the aftereffects\nof uncontrolled hypertension.\nElaborating further on the need to control the severity and long terms effects of Hypertension, Dr.\nPrasanna Kumar Gupta and Dr.J. Selva Kumar – Senior Consultants – Diabetology at Dr. Mohan’s\nDiabetes Specialties Centre – Tambaram branch expressed “Hypertension has always been an\nextremely common co-morbid condition in diabetes, affecting approximately 20-60% of the\nindividuals with diabetes leading to complications in all populations and occurs with increasing\nfrequency with advancing age. Both disorders are potent independent risk factors for cardiovascular,\ncerebral, renal, and peripheral atherosclerotic vascular disease. Hypertension is more prevalent in\ndiabetic men than diabetic women below 50 years of age and more common in women thereafter.\nOne needs to be vigilant and cautious of the risk factors of hypertension in most countries like\ndiabetes mellitus, obesity, sedentary behaviour, alcohol, higher social class, salt intake and smoking\netc. Timely diagnosis, medication, regular check-ups, proper diet and healthy lifestyle needs to be on\ntop priority for countering Hypertension.”\nDr. Mohan’s Diabetes Specialities Centre – Tambaram branch is located at Kalidasan Street in East\nTambaram and has all facilities for treatment and diagnosis of top class Diabetes care and", "label": "Yes"}
{"text": "Experts study why a family from Switzerland has not fingerprints.\nThursday, August 9 2012\nNo fingerprints.- For generations, all members of a Suisse family are born without fingerprints, neither on their fingers tips nor on their palms and toes.\nNow, a study published in the scientific magazine \"The American Journal of Human Genetics\" reveals that a strange mutation of the gen SMARCAD1 is the cause of these atypical cases. The study is based in a series of researches developed with the help of this Suisse family.\nnvestigators have also concluded that this genetic mutation can contribute to the apparition of small problems such as lack of perspiration in the hands and feet.\nThe conclusions of this research remind us that it is still a long way ahead and many discoveries to come through in the fascinating world of human DNA.", "label": "Yes"}
{"text": "Mesenteric adenitis means swollen (inflamed) lymph glands in the tummy (abdomen), which causes tummy pain. It is sometimes called mesenteric lymphadenitis. The mesentery is the part of the tummy where the glands are located. Adenitis means inflamed lymph glands.\nWhat is the cause?\nMesenteric adenitis seems to be caused by swollen lymph glands (also called lymph nodes) in the tummy (abdomen). The affected lymph glands are next to the gut (intestine). The swelling of the lymph glands is caused by an infection, usually a viral infection.\nRead more about the causes of mesenteric adenitis.\nHow common is it?\nMesenteric adenitis is a fairly common cause of tummy (abdominal) pain in children aged under 16 years. It is much less common in adults.\nWhat are the symptoms?\nMesenteric adenitis is usually a mild condition which causes temporary pain in the tummy, usually in children. The symptoms of mesenteric adenitis often start following a sore throat or symptoms of a cold. The main symptoms of mesenteric adenitis are:\n- A sore throat or symptoms of a cold before the tummy pain started.\n- Pain in the tummy. The pain is usually in the middle of your tummy (near your belly button). The pain may be in the lower right-hand side of the tummy (called the right iliac fossa).\n- High temperature (fever) and feeling generally unwell.\n- Feeling sick (nausea) and/or diarrhoea.\nHow is it diagnosed?\nMesenteric adenitis is usually diagnosed from your symptoms and an examination of your tummy (abdomen). The only problem is when other more serious conditions can't be ruled out. Tests such as blood tests, a urine test for infection, or scans (ultrasound or CT scan) may be needed to rule out other possible causes of abdominal pain. See also the leaflets called Appendicitis and Abdominal Pain.\nFind out more about the diagnosis of mesenteric adenitis.\nWhat is the treatment?\nUsually, no treatment is needed for mesenteric adenitis other than painkillers (if needed). If infection with a germ (a bacterial infection) is suspected, you may be given antibiotic medication, but this is uncommon.\nYour doctor will advise about the symptoms to look out for which suggest that you should be seen urgently for review. For example, increasing pain or becoming more unwell mean you should seek further advice straightaway.\nWhen might an operation be needed?\nIn some cases, problems such as appendicitis or ectopic pregnancy cannot be totally ruled out, even after tests. If so, you may need an operation to look inside your tummy to check for any suspected problem. Sometimes this can be done as keyhole surgery (laparoscopy), where a thin fibre-optic telescope is used to look inside the tummy.\nIf you have an operation or laparoscopy then the inflamed glands may actually be seen. However, the purpose of the operation is not to look for swollen glands, but to make sure other important problems, like appendicitis, are not missed.\nWhat is the outlook?\nThe symptoms usually improve within a few days, and will almost always clear up completely within about two weeks. Rarely, if infection with a germ (bacterium) is the cause, the condition can become serious if left untreated.\nFurther reading and references\nKim JS; Acute Abdominal Pain in Children. Pediatr Gastroenterol Hepatol Nutr. 2013 Dec16(4):219-224. Epub 2013 Dec 31.\nHumes DJ, Simpson J; Acute appendicitis. BMJ. 2006 Sep 9333(7567):530-4.\nGroselj-Grenc M, Repse S, Vidmar D, et al; Clinical and laboratory methods in diagnosis of acute appendicitis in children. Croat Med J. 2007 Jun48(3):353-61.\nHi all,Im freaking out Right now!I have raynauds phonomenom Primary for now as i havent had tests to see if i have Ań underlying cause which i think i do and possibly auto immune related anyway for...MidnightMystery\nDisclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.", "label": "Yes"}
{"text": "Biogenic amines modulate key behaviors in both vertebrates and invertebrates. In Caenorhabditis elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but not dilute (30%) octanol. TA and OA also abolish food- and serotonin-dependent increases in responses to dilute octanol in wild-type but not tyra-3(ok325) and f14d12.6(ok371) null animals, respectively, suggesting that TA and OA modulated responses to dilute octanol are mediated by separate, previously uncharacterized, G-protein-coupled receptors. TA and OA are high-affinity ligands for TYRA-3 and F14D12.6, respectively, based on their pharmacological characterization after heterologous expression. f14d12.6::gfp is expressed in the ASHs, the neurons responsible for sensitivity to dilute octanol, and the sra-6-dependent expression of F14D12.6 in the ASHs is sufficient to rescue OA sensitivity in f14d12.6(ok371) null animals. In contrast, tyra-3::gfp appears not to be expressed in the ASHs, but instead in other neurons, including the dopaminergic CEP/ADEs. However, although dopamine (DA) also inhibits 5-HT-dependent responses to dilute octanol, TA still inhibits in dop-2; dop-1; dop-3 animals that do not respond to DA and cat-2(tm346) and Pdat-1::ICE animals that lack significant dopaminergic signaling, suggesting that DA is not an intermediate in TA inhibition. Finally, responses to TA and OA selectively desensitize after preexposure to the amines. Our data suggest that although tyraminergic and octopaminergic signaling yield identical phenotypes in these olfactory assays, they act independently through distinct receptors to modulate the ASH-mediated locomotory circuit and that C. elegans is a useful model to study the aminergic modulation of sensory-mediated locomotory behaviors.", "label": "Yes"}
{"text": "Epidemiologic evidence supports the positive association of cardiopulmonary morbidity and mortality, and lung cancer risk with exposure to airborne particulate matter (PM). Oxidative stress and inflammation have been proposed to be the major causal factors involved in mediating PM effects on both cardiovascular and pulmonary health outcomes. However, the mechanism whereby PM causes the health effects is not fully elucidated. To evaluate and investigate human exposure to PM, it is essential to have a specific, sensitive and robust characterization of individual exposure to PM. Biomarkers may mark important intermediate steps leading to overt health effects after PM exposure. Thus biomarkers are promising indicators, which could serve as representative measures of the exposure to PM for assessing the health impacts and understanding the mechanism. Indeed, a number of biomarkers are already in use in the field of epidemiological studies and toxicological research. However, we are facing now the challenges to select robust, specific and sensitive biomarkers, which can be employed in large-scale of population to assess the health risk and to monitor the effectiveness of interventions. In this review, we describe a range of biomarkers that are associated with air pollution exposure, particularly markers of oxidative stress, inflammatory factors, and microRNAs, as well as markers of pollutants metabolites. Understanding the nature of the association of these biomarkers with PM exposure may shed some light on the process of selecting biomarkers for large-scale population studies, developing novel preventative and therapeutic strategies.", "label": "Yes"}
{"text": "According to some overly hyped biology professors and students, eugenics is considered to be beneficial and possible. However, it will never be beneficial or possible because it can never work. The reason eugenics may be considered as a possibility is due to the technological advances in genetic engineering. Some people are under the illusion that genetic engineering can finally validate eugenics.\nIt cannot do this and never will.\nValidating eugenics is not only wrong on a moral level but a scientific one. It is difficult to settle an agreement on the morality of eugenics because people may have different moral values, but eugenics cannot be scientifically validated and therefore should never be considered beneficial or valid ever again.\nEugenics is like a weed that keeps popping out of a garden, destroying nutrients for the pretty flowers and vegetables and taking up space when it is completely unnecessary and does not belong in the garden. We need to stop attempting to validate a weed in a garden when the weed does not belong there. Instead of allowing the weed to keep popping up after destroying its leaves, we need to pull it out by the roots. We can scientifically do this with eugenics.\nIt began with Francis Galton, a knighted polymath-psychologist-inventor-meteorologist-geographer and creator of the concept of correlation. He attempted to ascertain individual differences in psychology and tried to validate eugenics. He believed that only \"intelligent\" people should reproduce to create a better human race. He tried to follow Mendel's genetic principles to see if this was possible. He believed that there were \"defective\" families. Guess what, he was wrong.\nThe reason for this can be understood by Alfred Adler, the founder of the idea of the superiority and inferiority complex. According to Adler, people have a sense of inferiority and try to gain superiority over their environment. This sometimes is applied to feeling superiority over other people. People tried to validate feeling superior to other people via eugenics. These erroneous ideals were manifested in Hitler during World War II. Hitler believed that only the most \"purest\" blondes and blue-eyed people should procreate because they exhibited Aryan features.\nFortunately, Hitler was proven wrong. There is no intellectual difference in people based upon their skin tone, eye color, hair color, and religion. Although eye color, hair color, and skin tone are more heritable, intelligence is not.\nSo why are people trying to validate eugenics after Hitler was proven wrong? The answer is genetic engineering.\nThere are people who believe that they can \"design\" the perfect child, and these people are also wrong. People need to stop trying to validate eugenics when it is not scientifically possible.\nThe reason why eugenics will never work is because of the nature vs. nurture controversy. Although we have genomes that give us the material for how we grow and develop, these genes are activated by our environment throughout our lives. Genes are like light switches. If a fetus is given the right nutrients while in the womb, then all the right switches will be turned on and off at the right times. However, genes are also dependent upon how the person interacts with their environment for the rest of their life.\nPeople are under the impression that they can force a child to have all the \"right\" genes and be a perfect child. However, those genes will not be activated correctly unless that child is under \"perfect\" environmental conditions.\nFor argument's sake, let's say that someone could provide the \"perfect\" environmental conditions for the \"perfect\" child to grow up. Eugenics still will not work because we don't have one single gene for every trait, talent, or temperament.\nAccording to 23andme.com, there is no gene that gives someone perfect quarterback skills in football. There is no gene that makes someone a perfect dancer, singer, scientist, or doctor. There are no genes that account for kindness, integrity, being goal-oriented, discipline, charisma, or beauty. There may be a gene for dark hair, but not an exact shade. There may be a gene for athletic muscles, but not the entire build of a person's body. We cannot determine the full body shape of genetics.\nThere is 1 gene associated with episodic memory, 1 gene that is associated with dyslexia, and 1 gene for learning from errors. These 3 genes are the closest to measuring genetic intelligence, but not even these genes can determine full intellectual potential. They can increase the power of episodic memory, severe dyslexia, and learning from errors. Although these traits are associated with intelligence, they cannot fully determine intelligence when they are isolated.\nThe human genome is too convoluted for eugenics because certain traits are produced from the complex interactions of multiple genes that we do not understand. Even if we could understand them, they would only be activated by the right environmental cues. To make the \"perfect\" person would be to genetically engineer them and control every single environmental factor in that person's life. It's not possible. The human genome is like clay that is sculpted by the environment to each and every one of us. The environment has a little more power and influence.\nMorally, eugenics is also wrong. Eugenics tries to validate superiority complexes of people who are actually on equal ground with everyone else. We are all human. We all convert oxygen into carbon dioxide, we all drink water, and we all matter because we are made of matter and how we feel matters.\nStop trying to validate eugenics because it will always be scientifically and morally wrong.", "label": "Yes"}
{"text": "COP15 on Biodiversity ended this Monday in Montreal. Here is a non-exhaustive press review of the articles published on the subject in the international press.\nBiodiversité: Plus de la moitié du PIB mondial dépend de la nature - Saving biodiversity will not happen without them. Major cause of the problem, by their destruction of the ecosystems, the companies are also essential to reverse the tendency because the public money will not be enough. They have in their hands the greening of the economy. (Trends)\nBiodiversité : la COP15 s’achève sur un accord surprise - The Chinese presidency of the conference took the negotiators in Montreal by surprise, resulting in a relatively ambitious agreement in the middle of the night. (Le Point)\nCop15: historic deal struck to halt biodiversity loss by 2030 - Agreement on ’30 by 30’ target forced through by Chinese president, ignoring objections from African states. (The Guardian)\nLa biodiversité, à la fois victime et outil de lutte contre le réchauffement climatique - After the COP27 on climate change, representatives from around the world met in Montreal for the COP15 on Biodiversity, with a new challenge: to approve a roadmap to safeguard nature by 2030. This is a crucial issue, say scientists, especially for the major role that biodiversity plays in the fight against climate change, even though it is one of the first victims. (France24)\nFSC at COP 15: Highlighting Forest Stewardship as a Biodiversity Solution - FSC International participated in the second phase of the 15th Conference of the Parties (COP 15) of the UN Convention on Biological Diversity. (FSC)\nCOP15 : au-delà des promesses, le combat n’est pas gagné sur la biodiversité - More than 190 countries, gathered on Monday at the COP15 in Montreal, have reached a historic agreement to try to stop the destruction of biodiversity. But without a binding mechanism, many of the commitments made are likely to remain unfulfilled.\nSome LinkedIn posts about the COP15\nComité français de l’UICN : On December 12 and 13, Florence Clap, Biodiversity Policy Program Officer, participated in the business forum of the COP15 Biodiversity in Montreal.\nWildlife Conservation Society : WCS's Joe Walston spoke yesterday at the UN Biodiversity Conference to remind governments why we are here: CoP15 could be the catalyst for a renaissance for nature.\nUN Biodiversity : Nations adopt four goals, 23 targets for 2030 in landmark UN Biodiversity Agreement.\nActu-Environnement : The issue of the exploitation of genetic resources is postponed to COP16\nGlobal Environment Facility : During the CBD COP 15 on Wednesday, 14 December, Carlos Manuel Rodriguez, CEO and Chair, Global Environment Facility (GEF), facilitated a discussion with countries and institutions involved in the conservation of primary forests and their multiple ecosystem services.", "label": "Yes"}
{"text": "B7-H3 is a new member of the B7 family. The receptor for B7-H3 has not been identified, but it seems to be expressed on activated T cells. Initial studies have shown that B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. Thus, the immunological function of B7-H3 is controversial and unclear. In this study, we investigated the effects of neutralizing anti-B7-H3 mAb in a mouse model of allergic asthma to determine whether B7-H3 contributes to the development of pathogenic Th2 cells and pulmonary inflammation. Administration of anti-B7-H3 mAb significantly reduced airway hyperreactivity with a concomitant decrease in eosinophils in the lung as compared with control IgG-treated mice. Treatment with anti-B7-H3 mAb also resulted in decreased production of Th2 cytokines (IL-4, IL-5, and IL-13) in the draining lymph node cells. Although blockade of B7-H3 during the induction phase abrogated the development of asthmatic responses, B7-H3 blockade during the effector phase did not inhibit asthmatic responses. These results indicated an important role for B7-H3 in the development of pathogenic Th2 cells during the induction phase in a murine model of asthma.\nAllergic asthma is characterized by chronic airway inflammation with massive infiltration of eosinophils, increased mucus production in the bronchioles, and airway hyperreactivity (AHR)4 to a variety of specific and nonspecific stimuli. Although a variety of cell types is involved in allergic inflammation, there is substantial evidence that infiltration of Th2 cells is common in the lungs of allergic asthmatic subjects, as are increased levels of Th2 cytokines, including IL-4, IL-5, IL-10, and IL-13, particularly in the late phase (1, 2). The level of Th2 cytokines appears to correlate with severity of disease. These cytokines are responsible for the recruitment and activation of other cell types, including eosinophils, which have been associated with lung injury. They also mediate the production of mucus by the airway epithelium, contributing to the airway obstruction that is a major component of the pathology of asthma (3, 4, 5). Although the critical roles of these Th2 cytokines in the pathogenesis of allergic asthma have been established, the mechanisms for the overproduction of Th2 cytokines in asthmatic responses have not been fully understood.\nOptimal activation of Ag-specific T cells requires engagement of the TCR with Ag/MHC and a costimulatory signal provided by APCs (6, 7). It is well known that CD28-B7 (CD80 and CD86) interaction plays a major role in providing a costimulatory signal for T cells (8, 9). Blocking mAb to CD86 inhibits the development of specific IgE, pulmonary eosinophilia, and AHR in mice (10). CTLA-4 is a second receptor for CD80 and CD86, and CTLA4-Ig, a soluble fusion protein, has also been effective in blocking AHR (11, 12). Blockade of these costimulatory pathways markedly reduced allergen-induced asthma in mice, suggesting a promising approach for the treatment of allergic disease in humans.\nB7-H3 is a recently identified member of the B7 family (13, 14). Human B7-H3 protein is not expressed constitutively on monocytes, B cells, T cells, or NK cells, but it can be induced on these cell types by some stimulation (13, 15). Mouse B7-H3 mRNA expression is stimulated in dendritic cells (DCs) by IFN-γ, but suppressed by IL-4 (16). LPS stimulates B7-H3 protein expression on mouse DCs, B cells, and macrophages (16). The receptor for B7-H3 has not yet been identified, but it is thought to be expressed by activated T cells and is apparently distinct from other known T cell costimulatory receptors (13, 14). Some studies support roles for B7-H3 as a stimulator or an inhibitor of T cell responses. Initial studies showed that in conjunction with anti-CD3, B7-H3-Ig fusion protein costimulated human CD4+ and CD8+ T cell proliferation and IFN-γ production (13). A subsequent study also showed a costimulatory effect of B7-H3 on tumor immunity in a mouse model (17). However, recent studies have indicated that B7-H3 has an inhibitory function. Proliferation and cytokine production of purified human CD4+ T cells in response to anti-CD3 and anti-CD28 were inhibited by addition of B7-H3-transfected cells (18). Immobilized mouse B7-H3 inhibited mouse CD4+ and CD8+ T cell proliferation and IL-2 and IFN-γ production induced by anti-CD3 (16). Studies with B7-H3-deficient mice also support both stimulatory and inhibitory functions of B7-H3. B7-H3 has been proposed to promote T cell-mediated immune responses, based on the reduced rates of acute and chronic cardiac allograft rejection in B7-H3-deficient mice as compared with wild-type recipients (19). In contrast, under Th1-polarizing condition, B7-H3-deficient mice developed more severe airway inflammation than control wild-type mice (16). Thus, the immunological function of B7-H3 is controversial and still unclear. This study therefore examined the contribution of B7-H3 to the development of allergic asthma by administering a newly generated anti-B7-H3 mAb to a mouse model of asthma, particularly focusing on the role in induction and effector phases. Our present results suggest an important role for B7-H3 in the development of pathogenic Th2 cells during the induction phase, but not in the recruitment and/or activation of Th2 cells in the lung during the effector phase.\nMaterials and Methods\nAnimals and cells\nFemale BALB/c mice were purchased from CLEA Japan. All mice were 6–8 wk old at the start of experiments and kept under specific pathogen-free conditions during the experiments. All animal experiments were approved by Juntendo University Animal Experimental Ethics Committee and complied with National Institutes of Health guidelines for animal care. Six-week-old female Sprague Dawley rats were purchased from Charles River Laboratories. Mice transgenic for the OVA323–339-specific and I-Ad-restricted DO11.10 TCR-αβ on a Rag-2−/− BALB/c background were supplied by S. Koyasu (Keio University School of Medicine, Tokyo, Japan) (20). Stable L5178Y (murine T lymphoma) and P815 (murine mastcytoma) cells expressing B7-1, B7-2, B7-H1 (PD-L1), B7-DC (PD-L2), or B7RP-1 (B7-H2) were established previously (21, 22, 23). A cDNA fragment encoding the entire open reading frame of mouse B7-H3 was prepared by RT-PCR. The PCR product was cloned into pMKITneo vector and transfected into L5178Y and P815 by electroporation. Muirne B7-H4-transfected P815 cells were provided by M. Azuma (Tokyo Medical and Dental University, Tokyo, Japan). These cells were cultured in RPMI 1640 medium containing 10% FCS, 10 mM HEPES, 2 mM l-glutamine, 0.1 mg/ml penicillin and streptomycin, and 50 μM 2-ME.\nGeneration of anti-mouse B7-H3 mAbs\nThe anti-mouse B7-H3 mAbs were generated by immunizing Sprague Dawley rats with B7-H3-Ig, consisting of the extracellular domain (aa 1–242 of mouse B7-H3) (14) linked to the Fc portion of mouse IgG2a, emulsified in CFA (Difco). Three days after the final immunization, lymph node (LN) cells were fused with P3U1 myeloma cells. After hypoxanthine-aminopterin-thymidine selection, hybridomas (MJ8, rat IgG2b/κ, and MJ18, rat IgG1/κ) producing anti-B7-H3 mAb were selected by their reactivity to mouse B7-H3-transfected cells, but not to parental cells by flow cytometry, and then cloned by limiting dilution. The mAbs were purified from ascites by the caprylic acid and ammonium sulfate precipitation method, and purity was verified by SDS-PAGE analysis.\nFlow cytometric analysis\nCells (0.5–1 × 106) were first preincubated with unlabeled anti-CD16/32 mAb to avoid nonspecific binding of Abs to FcγR, and then incubated with biotinylated mAbs. After washing with PBS twice, the cells were incubated with PE-labeled streptavidin. Anti-CD86 (GL1) and anti-B7-H4 (clone 9) mAbs, rat IgG isotype control, and PE-labeled streptavidin were purchased from eBioscience. The hybridomas producing mAb against B7-1 (1G10) were purchased from American Type Culture Collection. Anti-B7RP-1 (HK5.3), anti-B7-H1 (MIH6), and anti-B7-DC (TY25) mAbs were prepared, as described previously (22, 23). After washing with PBS twice, the stained cells (live gated on the basis of forward and side scatter profiles and propidium iodide exclusion) were analyzed on a FACSCalibur (BD Biosciences), and data were processed using the CellQuest program (BD Biosciences).\nIn vitro T cell proliferation assay\nCD4+ T cells were purified from the spleen of DO11.10/Rag-2−/− mice or BALB/c mice by passage through nylon wool column (Wako Biochemicals) and by using autoMACS columns with CD4+ T cell isolation kit (Miltenyi Biotec), according to the manufacturer’s instructions. Purified CD4+ T cells (1 × 105/well) from DO11.10/Rag-2−/− mice were cultured with bone marrow-derived DCs (BMDCs; 2 × 104/well) and 2 μM OVA323–339 peptide in the presence or absence of anti-B7-H3 mAbs (10 μg/ml). Purified CD4+ T cells (1 × 105/well) from BALB/c mice were stimulated with immobilized anti-CD3 (2C11) mAb (0.5 μg/ml) and mouse rB7-H3 (rmB7-H3) (2 μg/ml; R&D Systems) in the presence or absence of anti-CD28 (PV-1) mAb (0.5 μg/ml) and anti-B7-H3 mAbs (10 μg/ml). Anti-CD28 (PV-1) mAb was provided by R. Abe (Tokyo University of Science, Chiba, Japan) and C. June (University of Pennsylvania, Philadelphia, PA). To assess proliferative responses, the cultures were pulsed with [3H]thymidine (0.5 μCi/well; GE Healthcare) for the last 6 h of a 48-h culture and harvested on a Micro 96 Harvester (Molecular Devices). Incorporated radioactivity was measured on a microplate beta counter (Micro β Plus; Wallac).\nInduction of allergic airway inflammation and mAb treatment\nGroups of 10 mice were sensitized by i.p. injection of 10 μg of OVA (Sigma-Aldrich) with 2 mg of alum (Pierce) (OVA/alum) on days 0 and 14. On days 22, 24, 26, and 28, the mice inhaled aerosolized 30 ml of 1% OVA in PBS (OVA/PBS). The aerosol was generated by nebulizer (NE-U07; Omron). Some groups of mice were i.p. injected with 300 μg of anti-B7-H3 mAb (MJ18) or control rat IgG (Sigma-Aldrich) on days 0, 2, 4, 7, 11, 14, 16, 18, 21, 24, and 27. Negative control animals were sensitized by i.p. injection of PBS with alum (PBS/alum) on days 0 and 14, and inhaled PBS in a similar manner. Two days after the last OVA inhalation, AHR was measured and bronchoalveolar lavage fluid (BALF) was collected, as described below. To examine the effect of anti-B7-H3 mAb in the induction phase, mice were injected with 300 μg of anti-B7-H3 mAb or control rat IgG on days 0, 2, 4, 7, 11, 14, 16, and 18. To examine the effect in the effector phase, mice were injected with the same dose of anti-B7-H3 mAb or control rat IgG on days 21, 24, and 27.\nMeasurement of AHR\nAHR was measured by methacholine (WAKO)-induced airflow obstruction. Mice were placed into whole-body plethysmographs (Buxco Research Systems) interfaced with computers using differential pressure transducers. Airway resistance is expressed as: enhanced pause (Penh) = ((Te/0.3Tr) − 1) × (2Pef/3Pif), where Te = expiratory time (s), Tr = relaxation time (s), Pef = peak expiratory flow (ml), and Pif = peak inspiratory flow (ml/s). Increasing doses of methacholine were administered by nebulization (for 2 min), and Penh were calculated over the subsequent 5 min.\nCharacterization of BALF\nAfter AHR measurement, the trachea was cannulated with a polyethylene tube through which the lungs were gently lavaged with 0.5 ml of PBS containing 10% FCS four times (2 ml total of BALF). The total number of cells was determined by Turk dye exclusion. Differential cell count was performed by staining of cytospins with Diff-Quik (Sysmex International Reagents).\nHistological analysis of lung sections\nLungs were removed from mice that were not subjected to the bronchial lavage procedure. Lungs were inflated and fixed by intratracheal instillation of 20% buffered formalin (pH 7.4) at a constant pressure of 25 cm H2O for 24 h. After routine processing of successive dehydration, the lungs were embedded in paraffin and sectioned in a sagittal plain. Sections of 5 μm thickness were stained with H&E or periodic acid-Schiff (PAS) and Alcian blue (AB) as a measure of mucus production. To quantify the infiltration of eosinophils in the lung tissue, cell counting was performed in a blinded manner based on a 5-point scoring system, as follows: 0, no eosinophil; 1, few eosinophils; 2, a ring of eosinophils one cell layer deep; 3, a ring of eosinophils two to four cells deep; 4, a ring of eosinophils more than four cells deep. Scoring was performed in at least 15 different fields for each lung section. Mean scores were obtained from six animals. Airway mucus levels were determined by counting PAS- or AB-positive cells as a percentage of total epithelial cells in a blinded manner, according to methods described (24).\nStimulation of bronchial LN cells in vitro\nAfter AHR measurement, bronchial LN cells were isolated and pooled, and cultured in 96-well flat-bottom microculture plates at a density of 6 × 105 cells/well in the presence or absence of the indicated doses of OVA. To assess proliferative responses, the cultures were pulsed with [3H]TdR (0.5 μCi/well) for the last 6 h of a 72-h culture and harvested on a Micro 96 Harvester. Incorporated radioactivity was measured on a microplate beta counter. To determine the production of cytokines, cell-free supernatants were collected at 72 h and assayed for IL-4, IL-5, and IL-10 by ELISA using OptEIA kits (BD Biosciences), IL-13 using Quantikine Immunoassay (R&D Systems), and IFN-γ using Mouse IFN-γ ELISA Ready-SET-Go! kit (eBioscience), according to the manufacturer’s instructions.\nInduction of DCs and macrophages from bone marrow cells and immunization\nBMDCs were prepared by culturing bone marrow cells from BALB/c mice, according to the procedure developed by Lutz et al. (25). Briefly, bone marrow cells (2 × 106/100 mm bacteriological petri dish) were cultured in 10 ml of RPMI 1640 medium containing 10% FCS, 10 mM HEPES, 2 mM l-glutamine, 0.1 mg/ml penicillin and streptomycin, and 50 μM 2-ME, and supplemented with 20 ng/ml GM-CSF (eBioscience). On day 3, another 10 ml of RPMI 1640 medium containing 20 ng/ml GM-CSF was added, and on day 6 half of the culture supernatant was collected and centrifuged, and the cell pellet was resuspended in 10 ml of fresh RPMI 1640 medium containing 20 ng/ml GM-CSF and given back into the original plate. On day 8, CD11c+ BMDCs were isolated by incubation with anti-CD11c-coupled magnetic beads and positive selection over an autoMACS column, according to the manufacturer’s instructions. The purity was checked by flow cytometric analysis (>98% CD11c+). For Ag pulsing, 100 μg/ml OVA was added to the cultures, and then the cells were further cultured overnight. OVA-pulsed BMDCs were washed in PBS and immunized (3 × 105 cells) into the hind footpads of BALB/c mice (n = 5). Mice were i.p. administrated with 300 μg of anti-B7-H3 mAb (MJ18) or control rat IgG on days 0, 2, and 5 after immunization, and popliteal LNs were harvested on day 8. In another experiment, BALB/c mice (n = 5) were immunized s.c. in the neck with OVA/alum and i.p. administrated with 300 μg of anti-B7-H3 mAb or control rat IgG on days 0, 2, and 4 after immunization, and cervical LNs were harvested on day 7. LN cells were pooled from five mice in each group and restimulated with the indicated doses of OVA at 6 × 105 cells/0.2 ml in 96-well plates. The proliferative response and cytokine production were measured, as described above.\nBone marrow-derived macrophages (BMMacs) were also prepared by culturing bone marrow cells from BALB/c mice. Bone marrow cells (5 × 106/100 mm bacteriological petri dish) were cultured in 10 ml of RPMI 1640 medium with 50 ng/ml M-CSF (Wako). On day 3, nonadherent cells were aspirated, and 10 ml of RPMI 1640 medium containing 50 ng/ml M-CSF was added, and on day 6 adherent cells on the bottom of the plate were collected by 0.1% EDTA/PBS (>98% CD11b+). Purified BMMacs and BMDCs were stimulated with anti-CD40 (FGK45) mAb (5 μg/ml), IFN-γ (20 ng/ml), or IL-4 (20 ng/ml) at 37°C for 24 h.\nSignificant differences between two experimental groups were analyzed by unpaired Student’s t test. The results are expressed as the mean ± SEM. Values of p < 0.05 were considered significant.\nEstablishment of anti-mouse B7-H3 mAbs\nWe immunized Sprague Dawley rats with B7-H3-Ig chimera protein and screened the hybridomas producing mAb that reacted with B7-H3 transfectants, but not parental cells. Two mAbs, designated MJ8 and MJ18, were selected. As represented in Fig. 1,A, MJ8 reacted strongly with B7-H3-transfected cells (B7-H3/L5178Y and B7-H3/P815), but not with parental L5178Y and P815 cells. MJ18 bound to B7-H3-transfected cells weakly, but not to parental cells. Both MJ8 and MJ18 failed to bind to the other B7 family-transfected cells (B7-1/P815, B7-2/P815, B7RP-1/L5178Y, B7-H1/L5178Y, B7-DC/L5178Y, and B7-H4/P815) (Fig. 1,B), indicating that MJ8 and MJ18 are specific for B7-H3. We also examined the expression of B7-H3 on BMDCs and BMMacs, which were prepared by culturing bone marrow cells with GM-CSF or M-CSF, respectively, by staining with MJ8. As shown in Fig. 1,C, although B7-H3 expression was not found on unstimulated BMDCs and BMMacs, it was detectable on both BMDCs and BMMacs after stimulation with anti-CD40 mAb or IFN-γ for 24 h, but not with IL-4. Because B7-H3 expression was inducible on BMDCs, we further tested whether the anti-B7-H3 mAbs would affect the stimulation of Ag-specific CD4+ T cells by BMDCs. Purified CD4+ T cells from DO11.10/Rag-2−/− mice were cultured with BMDCs and 2 μM OVA323–339 peptide in the presence of anti-B7-H3 mAbs or control IgG. As shown in Fig. 2,A, the addition of OVA323–339 peptide induced CD4+ T cell proliferation, and this proliferation was not affected by MJ8. In contrast, addition of MJ18 significantly inhibited the CD4+ T cell proliferation. Similar activities of MJ8 and MJ18 were observed when purified CD4+ T cells from BALB/c mice were stimulated with anti-CD3 and anti-CD28 mAbs in the presence of rmB7-H3 (Fig. 2 B). No difference in CD4+ T cell proliferation was observed when rmB7-H3 was added to the culture with anti-CD3 mAb alone. However, rmB7-H3 significantly enhanced CD4+ T cell proliferation stimulated by anti-CD3 and anti-CD28 mAbs. This enhancement was not affected by addition of control IgG or MJ8. In contrast, the addition of MJ18 mostly abrogated the enhancement by rmB7-H3. Collectively, our in vitro results indicate a substantial involvement of B7-H3 in the CD4+ T cell proliferative responses in vitro, which can be blocked by MJ18.\nAnti-B7-H3 mAb treatment suppresses the development of asthmatic responses\nTo explore the contribution of B7-H3 to the pathogenesis of asthma, we administrated anti-B7-H3 mAb (MJ18) or control rat IgG from day 0 to 27 to a murine model of asthma. BALB/c mice were sensitized by injection of OVA with alum on days 0 and 14, and then challenged by inhalation of aerosolized OVA on days 22, 24, 26, and 28. On day 30, the control IgG-treated mice developed a typical asthmatic phenotype characterized by AHR to methacholine (Fig. 3,A) and accumulation of eosinophils in BALF (Fig. 3,B). Histological examination showed massive infiltration of eosinophils around the bronchioles (Fig. 3, C and F), and mucus overproduction in the bronchioles (Fig. 3, D, E, G, and H). In contrast, development of AHR (Fig. 3,A), accumulation of eosinophils (Fig. 3, B, C, and F), and overproduction of mucus (Fig. 3, D, E, G, and H) were greatly reduced in the anti-B7-H3-treated mice.\nThe amelioration of asthma by anti-B7-H3 mAb might result from modulation of OVA-specific CD4+ T cell responses. To address this possibility, bronchial LN cells were prepared on day 30, and proliferative response and Th2 cytokine production (IL-4, IL-5, and IL-13) against various doses of OVA were assessed. As represented in Fig. 3,I, OVA-specific proliferative response was almost abrogated in LN cells from the anti-B7-H3-treated mice as compared with those from the control IgG-treated mice. The production of IL-4, IL-5, and IL-13 was also significantly reduced in the anti-B7-H3-treated mice as compared with the control IgG-treated mice (Fig. 3 J). These results indicate that B7-H3 plays a critical role in the development of allergic asthma and Th2 responses in this model.\nEffect of anti-B7-H3 mAb treatment during induction or effector phase of allergic asthma\nAlthough the above results indicated a critical contribution of B7-H3 to the development of allergic asthma, it was not clear whether B7-H3 played a role during the induction phase of pathogenic Th2 cell development or during the effector phase of pathogenic Th2 cell migration and activation in the lung. We next examined whether B7-H3 played a role during the induction phase or the effector phase of allergic asthma. OVA-immunized BALB/c mice were treated with anti-B7-H3 mAb or control IgG at the time of OVA sensitization from day 0 to 18 for the induction phase or from day 21 to 27 before the first OVA inhalation for the effector phase. Administration of anti-B7-H3 mAb at the induction phase significantly inhibited development of AHR (Fig. 4,A), accumulation of eosinophils in BALF (Fig. 4,B), and eosinophilia and mucus overproduction in the lung (Fig. 4, C–H). In addition, anti-B7-H3-treated mice showed significantly reduced OVA-specific proliferative response and production of Th2 cytokines (IL-4, IL-5, and IL-13) in LN cells as compared with control IgG-treated mice (Fig. 4, I and J). In contrast, anti-B7-H3 mAb treatment at the effector phase did not inhibit development of AHR (Fig. 5,A), accumulation of eosinophils, and mucus overproduction in the lung (Fig. 5, B–H), or OVA-specific proliferative response and Th2 cytokine production in LN cells (Fig. 5, I and J). These results indicate a critical contribution of B7-H3 to the induction phase of allergic asthma, but B7-H3 dose not play a major role in the effector phase, including the migration and activation of pathogenic Th2 cells in the lung.\nAnti-B7-H3 mAb treatment inhibits priming Th2 response by OVA/alum\nTo further evaluate whether B7-H3 plays a critical role in priming of CD4+ T cells, BALB/c mice were immunized s.c. in the neck with OVA/alum and treated with anti-B7-H3 mAb or control IgG on days 0, 2, and 4. Cervical LN cells were harvested 7 days after immunization and restimulated in vitro with OVA, and proliferative response and Th2 cytokine production (IL-4, IL-5, and IL-10) were assessed. As represented in Fig. 6,A, OVA-specific proliferative response was significantly reduced in LN cells from the anti-B7-H3-treated mice as compared with those from the control IgG-treated mice. Production of Th2 cytokines was also significantly reduced in the anti-B7-H3-treated mice as compared with the control IgG-treated mice (Fig. 6 B). We also examined the effect of anti-B7-H3 mAb treatment on the induction of regulatory T cells, which were determined by flow cytometric analysis of CD4+CD25+ Foxp3+ cells in LN cells. The anti-B7-H3-treated mice exhibited no significant difference in the frequency of CD4+CD25+ Foxp3+ cell population within total CD4+ T cells (1.64 ± 0.12%) as compared with the control IgG-treated mice (1.70 ± 0.26%).\nAnti-B7-H3 mAb treatment inhibits priming of CD4+ T cell responses by OVA-pulsed BMDCs\nWe further tested the effect of anti-B7-H3 mAb treatment on DC-induced CD4+ T cell responses. BMDCs were prepared by culturing bone marrow cells from BALB/c mice with GM-CSF for 8 days, and than pulsed overnight with OVA. A total of 3 × 105 BMDCs was subsequently injected into the hind footpads of syngeneic mice, which were treated with anti-B7-H3 mAb or control rat IgG on days 0, 2, and 5. Popliteal LN cells were harvested on day 8 and restimulated with OVA in vitro. Consistent with the previously published results (26), LN cells from the control IgG-treated mice produced IL-4, IL-5, IL-10, and IFN-γ when restimulated with OVA in vitro (Fig. 6,C). In contrast, LN cells from the B7-H3-treated mice produced significantly reduced levels of IL-4, IL-5, IL-10, and IFN-γ (Fig. 6 C). An addition of anti-B7-H3 or control IgG in the cultures had no effect (data not shown). Taken together, our present results suggest that B7-H3 plays a critical role in the induction phase of asthmatic response, particularly the priming of Th2 response by DCs.\nTo explore the contribution of B7-H3 to the development of allergic asthma, we first generated anti-mouse B7-H3 mAbs (MJ8 and MJ18), which bound to B7-H3 cDNA transfectants, but not to those expressing the other B7 family molecules (B7-1, B7-2, B7RP-1, B7-H1, B7-DC, and B7-H4). Moreover, MJ18, but not MJ8, significantly inhibited CD4+ T cell proliferation stimulated by BMDCs or anti-CD3 and anti-CD28 mAbs with rmB7-H3. These results indicate that MJ18 used in this study is specific for mouse B7-H3 and can interrupt the interaction between B7-H3 and its putative receptor. The anti-B7-H3 mAb-treated mice showed a substantial reduction of the OVA-induced asthmatic responses. Moreover, the administration of anti-B7-H3 mAb during the induction phase effectively ameliorated the asthmatic responses, although it was not effective during the effector phase. In vitro restimulation of draining LN cells showed that the anti-B7-H3 mAb treatment significantly reduced OVA-specific proliferative response and production of Th2 cytokines (IL-4, IL-5, and IL-13). These results suggest that B7-H3 plays its major role in the development of pathogenic Th2 cells during the induction phase, but not in the recruitment or activation of Th2 cells in the lung during the effector phase. In support of this notion, we also found that the anti-B7-H3 mAb treatment inhibited the priming of OVA-reactive Th2 cells induced by OVA/alum immunization or OVA-pulsed BMDC immunization. Collectively, these results suggest that the most critical role of B7-H3 in the asthmatic responses is to facilitate the priming of pathogenic Th2 cells, and that B7-H3 delivers a positive signal to CD4+ T cells leading to enhanced proliferation and cytokine production.\nSeveral recent studies, however, indicated that B7-H3 might have inhibitory functions in certain circumstances. Under Th1-, but not Th2-polarizing conditions, B7-H3-deficient mice developed more severe airway inflammation than wild-type mice (16). B7-H3-deficient mice also developed experimental autoimmune encephalomyelitis 2 days earlier than wild-type mice, but disease severity and incidence were comparable to wild-type mice (16). These results suggested that B7-H3 could be involved in the suppression of Th1-mediated immune responses. Thus, the present suppression of asthmatic response by anti-B7-H3 mAb might be due to an augmentation of Th1 responses. However, this possibility seems unlikely because the anti-B7-H3 mAb treatment inhibited not only Th2-type cytokines, but also Th1-type IFN-γ production in LN cells from the mice primed by OVA-pulsed BMDCs. Moreover, IFN-γ was not detectable in OVA-restimulated LN cells from the anti-B7-H3-treated mice in Figs. 3 and 4 (data not shown). Therefore, the anti-B7-H3 mAb treatment inhibited Th2 development, but this did not result in a dramatic shift to Th1 responses. These results also suggest that the anti-B7-H3 mAb treatment potentially has an inhibitory effect on Th1-mediated immune responses. Further studies are required to address this possibility using Th1-polarized disease models.\nThe immunization of BALB/c mice with OVA/alum preferentially induces a Th2 response and high levels of serum anti-OVA IgG1 and IgE Abs. The blockade of B7-H3 abrogated the development of asthmatic responses and Th2 responses in LN cells. However, it should be noted that the anti-B7-H3 mAb treatment did not affect the serum levels of anti-OVA IgG1 and IgE even when mice were treated with anti-B7-H3 during both induction and effector phases (data not shown). These results indicate that B7-H3 does not contribute to the Ab production in the OVA-induced asthma model. We previously indicated that the blockade of B7RP-1, which is another member of the B7 family, by neutralizing anti-B7RP-1 mAb, abolished the development of CXCR5+ CD4+ T cells and germinal center B cells in the spleen in response to Ag immunization (27). The chemokine receptor CXCR5 confers responsiveness to B lymphocyte chemokine (CXCL13), which is produced by follicular stroma cells in the spleen, LN, and Peyer’s patches (28, 29). CXCR5 is constitutively expressed by circulating B cells and is required for their migration into B cell follicles in the secondary lymphoid organs (30, 31). A subset of CD4+ T cells also expresses CXCR5, which mediates their migration to the B cell follicles, where they provide cognate help to B cells (32, 33, 34, 35). Thus, CXCR5+ CD4+ T cells are referred to as follicular B helper T cells and differ from Th1 and Th2 cells (35, 36). The differential role of B7-H3 in Th2 response and Ab production may be explained by differential contributions of Th2 cells and CXCR5+ CD4+ T cells. Further studies are needed to address this possibility.\nIn conclusion, a potent inhibition of the inflammatory response in mouse model of asthma was observed with anti-B7-H3 mAb administration. B7-H3 appears to play a critical role in the development of pathogenic Th2 cells, and thus represents a novel target for intervention of allergic asthma.\nThe authors have no financial conflict of interest.\nThe costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.\nThis work was supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.\nAbbreviations used in this paper: AHR, airway hyperreactivity; AB, Alcian blue; BALF, bronchoalveolar lavage fluid; BMDC, bone marrow-derived dendritic cell; BMMacs, bone marrow-derived macrophages; DC, dendritic cell; LN, lymph node; PAS, periodic acid-Schiff; Penh, enhanced pause; rmB7-H3, mouse rB7-H3.", "label": "Yes"}
{"text": "Coronella austriaca, also known as the \"smooth snake,\" was one of the species in the study. Image credit: Wikimedia Commons\nConducting a global study of an entire sub-order of species is not a simple proposition. It requires huge amounts of data, conducted by field researches in locations around the world, that spans a decade or more. As a result, such studies are able to provide only a slight indication of trends.\nBut sometimes, the findings are so consistent, so compelling, that they cannot be ignored.\nVierpa aspis aspis was one of the many species found to be in decline. Image credit: Wikimedia Commons\nSuch was the case with a recent study of global snake populations. Combing through data on 17 snake populations covering eight species around the world, researchers observed an \"alarming\" decline in global populations.\nChris Reading, who led the project, explained:\nThis is the first time that data has been analyzed in this way, and what we've shown is that in different parts of the world we seem to have this steep decline in a short period.\nHe went on to say that \"it surprised us when we realised what we were looking at.\"\nAnother species in the study, Python regiusalso showed declines. Image credit: quantumdtell/Flickr\nThe data sets showed steep declines eight of the 17 populations—some by more than 90 percent. Only one population showed signs of an increasing population.\nDeclines were observed even in protected areas, indicating that something other than habitat loss may be a driver. Climatic events, the team proposed, could be one reason, though it is impossible to determine without further research.\nA similar study of global amphibian populations eventually led researchers to identify a chytridiomycosis epidemic as the major cause of declines of those species.\n\"The purpose of this paper was to say 'this is what we've found', and to say to other herpetologists 'now go and look at your own data',\" Reading explained, \"\"But I think that with so many populations in different places showing decline, it's more than co-incidence.\"", "label": "Yes"}
{"text": "Professor Luke O'Neill from Trinity College Dublin, Ireland, identified the protein in 2001. The protein, known as Mal, alerts the immune system to respond against invading bacteria. Now, Professor Adrian Hill from the Wellcome Trust Centre for Human Genetics, University of Oxford, UK, has shown that there are two variants of Mal in humans and that the combination of these variants determines how the immune system responds.\nThe results of the study, funded by the Wellcome Trust, Science Foundation Ireland, Irish Health Research Board and the Agency for Science, Technology and Research, Singapore, are published in the April edition of Nature Genetics this week.\n\"Mal is in effect an alarm system for the immune system,\" explains Professor O'Neill. \"When the body is infected with the malaria parasite or other germs, a set of sensors called 'toll-like receptors' (TLRs) lock onto the intruder. TLRs relay the detection via Mal, which wakes up the immune system to mobilise and defend us.\"\nHowever, working with patients in Kenya, the Gambia, Vietnam and the UK, Professor Hill and his team showed that there are two common variants of the protein, one which allows the immune system to work normally, the other resulting in too strong a stimulation. A person will carry a combination of two copies of the protein, one from the mother and one from the father.\n\"If you have the overactive type, you are twice as likely to succumb to infection because your immune system goes into overdrive, often leading to severe forms of the disease, in a manner akin to ‘friendly fire’,\" explains Professor Hill, a Wellcome Trust Principal Research Fellow. \"Similarly, if you have two copies of the less active form, the body does not fight the infection and you get the disease. The optimum situation is to have one copy of each variant, giving a balanced system, sufficient to mount a response, but not overly activating.\"\nThe researchers found that having the overactive Mal doubled the risk of disease, with a four times greater risk of severe malaria in some populations. Malaria and TB account for over five million deaths per year in the developing world, particularly amongst children.\n\"We hope that a drug that modulates the balance of Mal variants might prevent disease in those who are at greater risk,\" says Professor O'Neill. \"Our next step is to work towards developing such drugs.\"\nThe research has been welcomed by Dr Mark Walport, Director of the Wellcome Trust, which funds research into diseases of the developing world such as malaria and TB, mainly through its major overseas programmes.\n\"Malaria and TB present a major challenge to the health of people in the developing world,\" says Dr Walport. \"Particularly given the recent rise in the number of cases of drug-resistant strains, it is essential that we understand how the immune system responds to infection if we are to develop novel treatments.\"\nThe researchers also believe that the findings may provide a valuable insight into how dysfunctional immune systems can lead to non-infectious diseases, specifically autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.\nCraig Brierley | alfa\nWorld’s Largest Study on Allergic Rhinitis Reveals new Risk Genes\n17.07.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt\nPlant mothers talk to their embryos via the hormone auxin\n17.07.2018 | Institute of Science and Technology Austria\nFor the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.\nTo rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...\nFor the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.\nWhirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...\nPhysicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.\nA frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...\nOptical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.\n\"Put an excitation into the system and observe how it evolves.\" According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....\nUltra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.\nFree-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...\n13.07.2018 | Event News\n12.07.2018 | Event News\n03.07.2018 | Event News\n17.07.2018 | Power and Electrical Engineering\n17.07.2018 | Life Sciences\n16.07.2018 | Physics and Astronomy", "label": "Yes"}
{"text": "- Note that this small randomized trial found that postmenopausal women with mild cognitive impairment who received hormone replacement therapy had better cognitive assessment scores at 2 years than those who received placebo.\n- Be aware that the statistical significance only emerged after adjustment for APOE genotype -- larger studies will be needed to confirm the observed effect.\nHormone therapy slowed cognitive decline in postmenopausal women with mild cognitive impairment, according to results of a small, randomized, placebo-controlled clinical trial.\nIn 35 postmenopausal women with mild cognitive impairment followed for 2 years, those who received hormone therapy scored significantly better than a placebo group on the Montreal Cognitive Assessment (mean difference 3.85, 95% CI -0.46 to 8.16, P=0.043) and the Mini-Mental State Examination (mean difference 3.26, 95% CI 0.04-6.48, P=0.0319), reported researchers led by Byung-Koo Yoon, MD, of the Sungkyunkwan University School of Medicine in Seoul, Korea.\nThe treatment group did not score significantly better on the Alzheimer's disease Assessment Scale. In addition, there were no significant differences between the treatment and placebo groups in assessments of depression or quality of life, which are often associated with declines in cognitive function, Yoon's group wrote online in the Journal of the North American Menopause Society.\nThe therapy used in the study consisted of percutaneous estradiol (E2) gel and oral micronized progesterone (MP4). \"To our knowledge, this is the first study to report the therapeutic potential of percutaneous E2 gel combined with oral MP4 in mild cognitive impairment,\" the researchers said. \"All tests for general cognition ... showed obvious exacerbation over 24 months in the placebo group, whereas they remained unchanged in the MHT [menopausal hormone therapy] group, implying that MHT has potential beneficial effects on cognition.\"\nBetter scores on the Montreal Cognitive Assessment in the treatment group became evident at 18 months. Better function as measured by this test could have meaningful clinical implications because it is to date the most sensitive tool for assessing global cognitive ability in mild cognitive impairment, the researchers said.\nThe prospective, double-blind trial included 35 postmenopausal Korean women with mild cognitive impairment. Their mean age was 70 (range 57-82). All received the dementia drug donepezil (Aricept) for ethical reasons, the researchers explained. The initial dose of donepezil was 2.5 mg/d for the first week, which was then doubled for the next 4 weeks, and then increased up to 10 mg/d if tolerated. All participants were assessed for apolipoprotein E (APOE) genotype, an established risk factor for Alzheimer's and poor cognitive function.\nThe women were randomized to receive 100 mg/day of MP4 plus E2 percutaneous gel 0.1% applied to the forearm before sleep or lookalike placebos. The starting dose of E2 was 0.5 mg/d and was increased monthly up to 2 mg/day if well tolerated. Participants were followed for 2 years, and cognitive function was assessed every 6 months.\nThe primary outcome was change in cognitive function as measured by the Korean versions of the Montreal Cognitive Assessment, the Mini-Mental State Examination, and the Alzheimer's Disease Assessment Scale-Cognitive Subscale. Quality of life, depression, and the ability to perform activities of daily living were also assessed every 6 months with various tests.\nDuring the course of the study, nine of 17 participants in the placebo group progressed to have dementia (53%) versus eight of 18 patients in the treatment group (44%). However, in the initial univariate analysis, the investigators found no significant differences in cognitive function between the treatment and placebo groups. The differences became significant only after the team adjusted for Apo E genotype.\nAdverse events were more common in the treatment group (n=17; 90%) versus the placebo group (n=7; 39%). The most common events were vaginal spotting/bleeding, breast pain/change, and other genital discomfort, which are typical side effects of hormone therapy. No cardiovascular events, cancers, or deaths occurred in the treatment group, the investigators said.\nHormone therapy might improve cognitive function in a variety of ways, Yoon et al explained. The treatment boosts cholinergic functions in the basal forebrain, and evidence suggests it leads to synaptic plasticity in the prefrontal cortex and hippocampus, and may decrease the production of amyloid plaques.\nAsked for her opinion, JoAnn Pinkerton, MD, executive director of the North American Menopause Society, called the results promising, but emphasized they are preliminary and need to be confirmed: \"Based on the small numbers of women, hormone therapy (transdermal estradiol and progesterone) improved cognitive function in women who were early cognitive changers,\" she said via email. \"Larger trials are needed to evaluate the impact of hormone therapy use before the full onset of Alzheimer's disease to determine if there is a role for hormone therapy in preventing or slowing Alzheimer's disease.\"\nLimitations of the study, the researchers said, included the small sample size and the fact that the participants were all Korean, so it is possible that the results are not generalizable to other populations. \"Additional large-scale, long-term trials are needed to confirm our findings and eventually to determine whether MHT could delay or diminish mild cognitive impairment progression to dementia in postmenopausal elders.\"2 comments", "label": "Yes"}
{"text": "I went trillium hunting at Warwoman Dell. I did find a few just starting to come up but, none with flowers on them. One had a bud. On the right is a photo of a clump of Round Leaved Violets that was growing along the trail. Trail conditions are fairly poor as several trees have fallen across it during the winter. In a couple of weeks I expect the trilliums to really begin their season of blooms.", "label": "Yes"}
{"text": "Background: Larvae of several common species of parasitic nematodes obligately migrate through, and often damage, host lungs. The larvae induce strong pulmonary Type 2 immune responses, including T-helper (Th)2 cells as well as alternatively activated macrophages (AAMφ) and associated chitinase and Fizz/resistin family members (ChaFFs), which are thought to promote tissue repair processes. Given the prevalence of systemic or lung-resident Type 1-inducing pathogens in geographical areas in which nematodes are endemic, we wished to investigate the impact of concurrent Type 1 responses on the development of these Type 2 responses to nematode larval migration. We therefore infected BALB/c mice with the nematode Nippostrongylus brasiliensis, in the presence or absence of Plasmodium chabaudi chabaudi malaria parasites. Co-infected animals received both infections on the same day, and disease was assessed daily before immunological measurements were taken at 3, 5, 7 or 20 days post-infection. Results: We observed that the nematodes themselves caused transient loss of body mass and red blood cell density, but co-infection then slightly ameliorated the severity of malarial anaemia. We also tracked the development of immune responses in the lung and thoracic lymph node. By the time of onset of the adaptive immune response around 7 days post-infection, malaria co-infection had reduced pulmonary expression of ChaFFs. Assessment of the T cell response demonstrated that the Th2 response to the nematode was also significantly impaired by malaria co-infection. Conclusion: P. c. chabaudi co-infection altered both local and lymph node Type 2 immune activation due to migration of N. brasiliensis larvae. Given recent work from other laboratories showing that N. brasiliensis-induced ChaFFs correlate to the extent of long-term lung damage, our results raise the possibility that co-infection with malaria might alter pulmonary repair processes following nematode migration. Further experimentation in the co-infection model developed here will reveal the longer-term consequences of the presence of both malaria and helminths in the lung.\nAll Science Journal Classification (ASJC) codes", "label": "Yes"}
{"text": "The Anzali Ramsar Convention wetland is located in an ecologically and economically important region in Iran. The wetland is largely surrounded by agriculture, natural forests and rangelands (approximately 36% and 63%, respectively). Urban areas consist of less than 1% of the total area. Urban land use produces the highest rates of nutrient transfer into the lake as TN, TP and BOD5 equal to 24, 2.4 and 79 Kg/ha/year, respectively, whilst, natural land use produces the lowest rate as 10, 1.3 and 27 kg/ha/year. These results will inform the future sustainable management of this important wetland in this ever increasingly water stressed region in Iran.\n|Number of pages||5|\n|Journal||Bulletin of Environmental Contamination and Toxicology|\n|Publication status||Published - Feb 2010|\n- Ramsar wetlands\n- Transfer model", "label": "Yes"}
{"text": "Vijay G. Sankaran, MD, PhD\nAssociate Professor at Boston Children's Hospital\n2018 NYSCF – Robertson Stem Cell Investigator Alumnus\nMD, PhD, Harvard University\nResidency and Clinical Fellowship, Dana-Farber Cancer Institute, Boston Children’s Hospital; Postdoctoral Studies, Whitehead Institute, Broad Institute\nDr. Sankaran is an Associate Professor of Pediatrics at Boston Children’s Hospital, where his laboratory uses human genetics to better understand hematopoiesis and how it goes awry in human disease. In particular, he seeks to gain molecular insight into how hematopoiesis varies in humans both in health and disease, and to develop improved therapies for a variety of blood disorders. He completed his residency and clinical fellowship at Dana-Farber Cancer Institute and Boston Children’s Hospital, and his postdoctoral studies at the Whitehead and Broad Institutes.\n- How is Risk for Blood Cancers Inherited?\n- Our Community’s Top 10 Stem Cell and Neuroscience Breakthroughs of 2023\n- World’s First CRISPR-Based Gene Therapy Approved by FDA\n- What Can Make Leukemia Extra Aggressive?\n- Meet SCAVENGE: A Search Engine to Uncover How Genetic Variations Affect Our Cells\n- Vijay Sankaran Reflects On the Transformational Impact of the NYSCF - Robertson Investigator Award and Innovator Community\n- How the Genetics of Blood Stem Cells Can Lead to Cancer and Heart Disease\n- Community Continues from Afar: Highlights of the NYSCF Innovators Retreat", "label": "Yes"}
{"text": "When it comes to cannabis, there is a belief that the potency of a high is directly correlated with higher levels of THC. However, it is important to note that the strength of weed does not solely depend on THC content. In this article, we will delve into some of the key factors beyond THC levels that contribute to a strain’s potency levels.\nExploring the Entourage Effect: Beyond THC\nWhile THC is undoubtedly the most well-known cannabinoid compound in cannabis, it does not work alone in producing its psychoactive effects. The combination of cannabinoids and other compounds found in cannabis creates what experts refer to as the entourage effect. This collaborative interaction alters how different compounds interact with each other, ultimately influencing the experience of the high.\nRather than solely focusing on percentages of THC, experienced cannabis enthusiasts and connoisseurs seek out strains that are rich in multiple cannabinoids, such as CBD, CBN, CBG, and THCV, among others. Each cannabinoid affects our receptors differently, leading to an interplay of effects that can vary significantly from person to person.\nTerpenes. More Than Just Aromatics\nTerpenes play a role not only in providing distinct flavors and aromas to different strains but also contribute significantly to their overall characteristics and effects. However, these aromatic compounds not only contribute significantly to the benefits of cannabis, but they also bind to different receptors in our brains and bodies. This interaction plays a role in enhancing or mitigating the effects of cannabinoids like THC. For example, myrcene is a terpene commonly found in cannabis strains known for promoting relaxation and sedation. On the other hand, pinene enhances alertness. By considering the different terpene profiles rather than just focusing on THC concentration, users can tailor their desired experience based on specific strains.\nThe Importance of Genetic Variations in Cannabis Strains\nThe composition of a cannabis strain is another factor that determines its potency. Even if two strains have similar THC levels, they may not offer the same effects or possess the same strength. This variation in experience can be attributed to factors such as terpene profiles and the entourage effect mentioned earlier. The way these compounds interact within each strain is what ultimately shapes the experience of the high. As a result, two strains with THC concentrations can produce entirely different effects due to variations in their genetic makeup.\nThe Impact of Consumption Methods\nThe method of consuming cannabis also plays a key role in how it’s metabolized by the body and experienced by individuals. Smoking allows cannabinoids to enter the bloodstream quickly, leading to an immediate onset but shorter duration of effects. On the other hand, edibles offer a more consistent release of effects that can last longer, although it may take more time to feel their impact. When looking for a more potent high, it is crucial to consider the method of consumption. Trying out different techniques allows individuals to find the consumption method that suits them best.\nPersonal Factors – Unique Reactions\nWhen it comes to different strains of cannabis, personal factors play a major role as well. Each person’s unique biological makeup affects how they respond to cannabis. Variables like metabolism, tolerance levels, previous experiences, mental state, and overall health all influence how an individual’s body interacts with cannabis. What might be too strong for one person may not provide adequate effects for another. Hence, recognizing these factors is important when choosing strains and consuming cannabis products.\nWhile THC is often seen as the primary indicator of potency in cannabis strains, it does not provide the complete picture. Knowledgeable consumers understand that multiple cannabinoids, compositions, and genetic variations among strains matter more than just high THC percentages. By understanding these elements, from terpenes contributing to flavor and aroma to reactions influenced by genetic differences, consumers can make informed decisions when seeking a stronger or more potent cannabis experience. Keep in mind that it’s not just about the numbers. Instead, it involves acknowledging the intricacies of cannabis and discovering the strain that best suits your requirements and preferences. So, when you think about the strength of your marijuana, dig deeper than THC and explore the captivating range of compounds that influence our cherished herb.", "label": "Yes"}
{"text": "Introduction: The Androctonus australis hector (Aah) venom is a complex of high and low molecular weight components. Scorpion envenoming. Toxicol Appl Pharmacol. Feb 1;(3) Epub Nov Toxicokinetic and toxicodynamic analyses of Androctonus australis hector venom in. Androctonus australis hector insect toxin also known as AaHIT is a scorpion toxin which affects voltage-gated sodium channels. Four different insect toxins, Other Names: AaHIT or AaIT.\n|Author:||Durward Little DVM|\n|Published:||23 April 2016|\n|PDF File Size:||40.78 Mb|\n|ePub File Size:||35.98 Mb|\n|Uploader:||Durward Little DVM|\nThere are many pathways autoxidation of glucose, polyol pathway, protein glycation, formation of advanced glycation products… by which hyperglycemia can increase the ROS production.\nObtained results suggest that the inhibition of voltage-gated sodium channels before venom injection seems to induce a decrease androctonus australis hector blood glucose in hyperglycemic model and androctonus australis hector prevent some disturbances induced by hyperglycemia.\nImmunity — Nutrition — Cancer Citation: Description[ edit ] Androctonus australis is a medium-sized scorpion which can grow up to 10 centimeters in length.\nFab was more effective than F ab' 2 for preventing early symptoms of envenomation, whatever their route of administration. Intraperitoneal injection of F ab' 2 and Androctonus australis hector was similar for the prevention of the delayed symptoms, even after a late administration.\nFab was more effective than F ab' 2 in the inhibition of airway resistance, independent of the route and time of administration. Androctonus australis Linnaeus, Cardiac dysfunctioning androctonus australis hector pulmonary edema following scorpion envenomation.\nAndroctonus australis - Wikipedia\nChest, 4pp. Gifttier Informationsdienst on A. This scorpion is a medium sized scorpion which can get up to 10 cm in androctonus australis hector.\nJournal of Insect Physiology.\n- The Scorpion Files - Androctonus australis (Buthidae)\n- Androctonus australis hector insect toxin - Wikipedia\n- Androctonus australis hector venom effects on oxidative stress biomarkers in experimental model\nThe Journal of Neuroscience.", "label": "Yes"}
{"text": "Q.Why Leucadendron Safari Sunset Leaves Turning Brown?\nI got these very young Leucadendron plants two months ago. I followed the nursery guy told me and water them once every 3-4 days. He told me to water this frequency because the plants are still so young. I also followed what I was told using cactus soil mixed with all plant soil. The water seems drain fast. All three plants are slowly growing while started to have brown leaves. One of them has a whole branch turning brown. Please see the pictures. Would anyone tell me what did I do wrong? Too much water? Thank you.\nCertified GKH Gardening Expert\nThese plants will not tolerate wet soils. Even when they are young, they need to dry out very thoroughly between waterings. Unless your area is prone to extreme drought (Think African desert) you won't need to water at all.\nFrom here, you will want to halt watering, completely, and treat with a fungicide.\nThese articles will help:", "label": "Yes"}
{"text": "We all know we are supposed to exercise and eat well to maintain good health, but another factor that is essential to our health is sleep. Adults should sleep for 7 or more hours each night for optimal health. However, more than 1/3 of U.S. adults get less than that. The obvious consequences of lack of sleep are feeling tired, both physically and mentally, and having difficulty with thinking and memory. However, there are other more serious side effects of chronic sleep loss.\nLack of sleep can affect our health, putting us at an increased risk of heart disease, heart attacks, stroke, diabetes, and obesity. It can also play a role in our mental health as lack of sleep increases the risk of depression. In addition to those conditions, lack of sleep makes our immune system weaker. In fact, people who sleep less than 7 hours per night are 3 times more likely to get the common cold. Sleep apnea, which is a sleep disorder in which breathing repeatedly stops and starts, can also cause these health conditions and should be treated.\nWe also tend to look older when we have a lack of sleep as our body releases more stress hormones. On the other hand, we don’t release enough growth hormone, which helps grow and repair our muscles, skin, and bones. Not only does our body repair itself at night, but our brain does as well. While we sleep our brain forms new pathways to help us learn and remember new information, but it also flushes toxins out and gets rid of connections we don’t need.\nAlso, sleep can help reduce pain. Studies show that when we have sleep loss, we can tolerate less pain. On the other hand, a good night’s sleep has been shown to be as helpful as pain medication for pain relief. Obviously, sleep is a very important part of good health.\nIn addition getting more sleep for better health, we can also improve our quality of sleep by practicing “sleep hygiene.” This includes napping no longer than 30 minutes during the day, avoiding caffeine and alcohol close to bed time, exercising (but not too close to bedtime), avoiding heavy and rich foods right before bed, and making sure the sleep environment is comfortable. You can also make sure the temperature is below 67 degrees, the lights are off, you are not watching TV in bed, and maintain a regular sleep schedule.\nIf you have concerns regarding your sleep, you can always contact your primary care physician.", "label": "Yes"}
{"text": "Terms and conditions ~\nThere are lots of different kinds of Ajuga out there. Sclerotia. Also known as carpetweed or bugleweed, ajuga forms a 6-inch-tall mat of glossy leaves that always seem to look neat and fresh. Your Lightboxes will appear here when you have created some. https://www.alamy.com/ajuga-repens-lamiaceae-bugle-ajuga-reptans-image185003547.html. Habitats with lots of splashing rain and water flow will allow for rapid spread of the pathogen. S. rolfsii. Monitor these areas first for early signs of root diseases. Ajuga reptan 's common name, Bugleweed, would have made for a much less mysterious introduction, and until the late 1990's was considered just another green ground cover. Phytophthora crown rot on a young apple tree. This is particularly common in heavy soils or in hot, humid areas. Social media. Usually, there’s little you can do to save plants, so prevention is important. The plant also likes fairly moist soil but is remarkably adaptable and will even tolerate a little drought. Here are 30 recommended plants likely to succeed. Additionally, very heavy soil will cause crown rot. Ajuga reptans NC State University and N.C. A&T State University work in tandem, along with federal, state and local governments, to form a strategic partnership called N.C. While not the main attraction, its flower spikes are an appealing feature in the Spring. It is best planted in partial shade or even full shade, perhaps in the shadow of a house or tree that will protect it at least part of the day. It first appears as sudden wilting and dieback in colder climates and yellowing and death of plants in warmer areas. Ajuga-Crown Rot. When I lived in Mississippi I had a problem with crown rot one year. Ajuga plants tend to be healthy but crown rot can be a problem. Photo #1/27 of Bugleweed (Ajuga reptans 'Burgundy Glow'). Your tree may have an obvious decline that could be due to many factors, including fire blight and winter injury. ... You can help prevent crown rot by assuring the soil drains well. Crown rot can start when a plant lacks protection. Good air circulation is essential to avoid crown rot. Ajuga is a hit-and-miss success for me.After a couple of seasons it tends to die out in spots, and some years almost completely dissapears. The problem in Georgia was attributed to infected plants coming in from plug production facilities in Central America. It is an excellent plant for moist areas, although … Some are grown for their colorful foliage. Phytophthora Root and Crown Rot in the Landscape. Many susceptible ornamentals, such as daylily (Hemerocallis), impatiens, ajuga, peony, and vinca, are often planted in the same beds as hosta, so the disease can move from hosta to neighboring plants. Crown and Roots Rot; Odor Present is Caused by Crown Rot Soil-dwelling fungi cause this serious disease, which can kill plants within a few days. Backyard Gardener provides gardening tips on 33000 plants, with guidance on how to grow. Thinning is suggested about every 3rd year to reduce the chance of crown rot. The root system consists of a crown of fibrous roots. It will prevent the plant from going back to its original green form and it will help keeping its colors. Ajuga needs plenty of good air circulation and should be thinned out on occasion. Otherwise, it is fairly impervious to pests and diseases. June, https://www.alamy.com/stock-photo-bugle-ajuga-reptans-flowering-in-woodland-powys-wales-june-52274875.html, Ajuga reptans 'Burgundy Glow', perennial plant with attractive red, cream and green variegated leaves growing in decorative container, https://www.alamy.com/ajuga-reptans-burgundy-glow-perennial-plant-with-attractive-red-cream-and-green-variegated-leaves-growing-in-decorative-container-image221407324.html, Bugle Ajuga reptans colony growing on a grassy bank near Lyme Regis Dorset UK, https://www.alamy.com/stock-photo-bugle-ajuga-reptans-colony-growing-on-a-grassy-bank-near-lyme-regis-104857444.html, https://www.alamy.com/multicoloured-foliage-of-the-lao-growing-hardy-evergreen-perennial-ajuga-reptans-golden-beauty-image376955446.html, https://www.alamy.com/bugle-ajuga-reptans-image187136333.html, https://www.alamy.com/bugle-ajuga-reptans-image243976233.html, https://www.alamy.com/common-bugle-ajuga-reptans-image63644993.html, https://www.alamy.com/stock-photo-tea-made-of-bugle-medicinal-tea-herbtea-bugletea-ajuga-reptans-bugula-19332402.html, Blue Bugle or Carpet Bungleweed (Ajuga reptans), Schwaz, Tyrol, Austria, Europe, https://www.alamy.com/blue-bugle-or-carpet-bungleweed-ajuga-reptans-schwaz-tyrol-austria-image62086673.html, Bugle, Ajuga reptans, Monmouthshire, Wales, UK, https://www.alamy.com/bugle-ajuga-reptans-monmouthshire-wales-uk-image185679499.html, https://www.alamy.com/stock-photo-blue-bugle-flowers-ajuga-reptans-29487980.html, A Bugle wild flower (Ajuga reptans) close up, https://www.alamy.com/stock-photo-a-bugle-wild-flower-ajuga-reptans-close-up-31216343.html. Phytopathology 95:S111. Avoid planting in wet, heavy soils, provide good air circulation and divide when clumps become overcrowded. Cell Size: 72 cell tray.Depth 2.35\". Bugleweed Ajuga reptans 'Chocolate Chip' Ah-JEW-gah REP-tanz Synonyms of Ajuga reptans from Plants of the World Online: Ajuga alpina Fr., Ajuga barrelieri Ten., Ajuga breviproles Borbás, Ajuga densiflora Ten., Ajuga pyramidalis Huds., Ajuga repens Gueldenst. They can also get crown rot if you don’t thin them out every 3 years or so. It is vulnerable to Southern blight, a soil-borne fungus also known as crown rot. Spots appear on the crown (where stem and roots meet), lower leaves rot and young shoots wilt. (Senior Eds.). Their latest weapon? https://www.alamy.com/stock-photo-common-bugle-ajuga-reptans-in-flower-rainy-day-spring-38472798.html, https://www.alamy.com/stock-photo-bugle-ajuga-reptans-lamiaceae-48551517.html, https://www.alamy.com/stock-photo-rhinga-campestris-hoverfly-feeding-from-a-purple-bugle-ajuga-reptans-24014042.html, Kriechender Günsel, Ajuga reptans, bugle, blue bugle, bugleherb, bugleweed, carpetweed, carpet bungleweed, common bugle, La bugle rampante, https://www.alamy.com/stock-photo-kriechender-gnsel-ajuga-reptans-bugle-blue-bugle-bugleherb-bugleweed-140941979.html, https://www.alamy.com/ajuga-reptans-gnsel-bugle-image334595445.html, Bugle (Ajuga reptans) flowering in woodland. Crown rot, sometimes called southern blight or southern stem rot, is caused by several soil-borne fungi. Common Name(s): Ajuga; Blue Bugle; Bugleherb; Bugleweed; Bugle Weed; Carpet Bugle; Phonetic Spelling ah-JOO-gah REP-tans Description. Diseases that cause die back and browning of roots are often referred to as root rots. Sclerotium delphinii is the fungus that enters the plants through the roots and crowns and cuts off the water supply. https://www.alamy.com/bugleherb-ajuga-reptans-at-hendricks-park-in-eugene-oregon-usa-image245585993.html, https://www.alamy.com/stock-photo-ajuga-reptans-bugleweed-common-bugle-blue-flowers-flower-flowering-75807244.html, Close up of the blue common Bugle Ajuga reptans flowering in a woodland in the UK, https://www.alamy.com/close-up-of-the-blue-common-bugle-ajuga-reptans-flowering-in-a-woodland-in-the-uk-image356762753.html. https://www.alamy.com/stock-image-a-cultivar-of-bugle-ajuga-reptans-burgundy-glow-in-a-garden-167210473.html, Ajuga reptans 'Atropurpurea' close up of flowers, https://www.alamy.com/stock-photo-ajuga-reptans-atropurpurea-close-up-of-flowers-88468115.html, https://www.alamy.com/stock-photo-bugle-ajuga-reptans-lamiaceae-58253467.html, primula veris ajuga reptans cowslips bugleweed purple yellow flower flowers flowering planting combination scheme RM Floral, https://www.alamy.com/stock-photo-primula-veris-ajuga-reptans-cowslips-bugleweed-purple-yellow-flower-75809761.html, Ajuga reptans - `Atropurpurea' AGM- - (Syn. Crown Rot Identification and Habitat. As the season progresses, these will become increasingly visible. Crown rot is a disease caused by the fungus Fusarium pseudograminearum, and can attack all winter cereals and many grassy weeds. Part of OSU Extension Plant Pathology Slide Set. A low growing wildflower with stems of blue flowers. Ajuga plants are subject to crown rot if they are overcrowded or if conditions are too humid. lerezana Blanco-Dios, Ajuga reptans var. Management. It is vulnerable to Southern blight, a soil-borne fungus also known as crown rot. It has many uses and looks great much of the year. Keep in mind that although ajuga is considered a groundcover, it doesn't do well with foot traffic. Ajuga grows best in partial to full shade but will also grow in full sun if constant moisture is provided. Bugleweed (Ajuga) is a cold-hardy, easy-to-grow ground cover with blue to purple flower spikes. PNW Plant Disease Management . The presence of the pathogen within the plant stem limits water movement, which can result in premature death of the tiller and the presence of white (dead) heads. pyramidata Zalewski, Ajuga stolonifera Jeanb. In case you notice non-variegated foliage on variegated forms of Ajuga plants, make sure to remove it. Green stolons up to 12\" long are produced from the rosette of basal leaves. The crown should never be covered with soil or the plant will rot and die. can affect more than 500 different plant . Crown rot commonly infects plants starting at their base, and then spreads upwards throughout the plant. British Wild Flower. This fungal disease is most common in warm wet or humid weather. 2020 Pacific Northwest Plant Disease Management Handbook. Huge collection, amazing choice, 100+ million high quality, affordable RF and RM images. This fungal disease is most common in warm wet or humid weather. ex Ledeb., Ajuga reptans var. At least Garden Splendor says it's easy to divide simply by digging up, pulling it apart into fist-size clumps and replanting. Now: ... Crown rot can be a problem, particularly in humid conditions and wet, heavy soils. The nodes of the stolons are also very short, which creates very dense colonies ideal for preventing weeds from growing up through the plants. Ajuga, or Carpet Bugle, is one of the most carefree and attractive groundcovers around. Crown rot survives on infected stubble, from where it is passed onto the following crop. Propagate by division any time during the growing season. More specifically, temperatures between 86 to 95 degrees F will favor crown rot growth the most. If you have never grown Ajuga before, you will learn the ropes. Ajuga repens ,Lamiaceae , bugle. (Detailed plant information can be found at the bottom of the page.) Some of the miniature varieties make great additions to trough gardens and containers. ANSWER: This is crown rot, a common problem of ajuga in Louisiana. Fantastic tricolored foliage in shades of creamy-white, rose-burgundy, and dark green make this ajuga different than all the others. The genus Ajuga includes annuals and (usually) rhizomatous perennials in 40 species that come from shady habitats in temperate Europe and Asia. Bugle, Ajuga reptans, Lamiaceae. No need to register, buy now! The fungus attacks very suddenly, causing plants to collapse, wilt and die. Photo by William M. Brown Jr., Bugwood.org via CC 3.0. Southern Blight (fungus – Sclerotium rolfsii): Southern Blight, also called Crown Rot, is a soil-borne disease of ajuga that will be more serious in poorly drained soils. Avoid over-fertilizing. Once established, ajuga plants requires little care. The sclerotia story starts with hosta, the reigning glamor queen of shady northern landscapes. Note the discoloration at the base of the stems due to a Sclerotium sp. Ajuga reptans ‘Chocolate Chip’ on 4-12-15, #238-1. Pathogenicity of crown rot and root rot disease of Ajuga reptans caused by Phoma sp. Ajuga does best in well-drained, moist soil but handles drought and dry soils well. And in addition to the traditional green foliage, this ground cover can also provide the landscape with stunning copper or purple-colored foliage too, making it great for adding year-round interest. You can do it by simply mowing or cutting the foliage back to the ground. Ajuga reptans (Bugle). Dreamstime is the world`s largest stock photography community. Ajuga is one of the most indispensable groundcovers around. Temperatures below 70 degrees F will be less favorable for crown rot development. KarlGercens.com GARDEN LECTURES has uploaded 184850 photos to Flickr. ANSWER: This is crown rot, a common problem of ajuga in Louisiana. Ajuga spp.. A.r. It has many uses and looks great much of the year. Ajuga plants tolerates a wide range of soil conditions as long as the soil is well drained. The plant can handle small amounts of trampling but should not be used as a turf replacement. Almacena, descarga y comparte tus fotografías agrícolas - Infoagro https://www.alamy.com/stock-photo-ajuga-reptans-bugle-a-low-growing-wildflower-with-stems-of-blue-flowers-83220140.html, https://www.alamy.com/stock-photo-ajuga-reptans-burgundy-glow-30477625.html, https://www.alamy.com/stock-photo-ajuga-reptans-purple-delight-bugle-49372774.html, tea made of Bugle medicinal tea herbtea Bugletea Ajuga reptans Bugula te, https://www.alamy.com/stock-photo-tea-made-of-bugle-medicinal-tea-herbtea-bugletea-ajuga-reptans-bugula-19332407.html, https://www.alamy.com/stock-photo-blue-bugle-or-carpetweed-ajuga-reptans-34495232.html, Flowering spikes of the bugle, Ajuga reptans 'Catlin's Giant', https://www.alamy.com/stock-photo-flowering-spikes-of-the-bugle-ajuga-reptans-catlins-giant-30354341.html, https://www.alamy.com/stock-photo-bugle-flower-ajuga-reptans-in-blossom-with-the-colour-accented-by-26689636.html, Carpet bugleweed, Common bugleweed (Ajuga reptans), Belgium, https://www.alamy.com/stock-photo-carpet-bugleweed-common-bugleweed-ajuga-reptans-belgium-27503495.html, Bright cobalt blue flowers of Bugle plants. It first appears as sudden wilting and dieback in colder climates and yellowing and death of plants in warmer areas. Sites that are particularly wet or poorly drained will have this problem more than well-drained areas. Cause The fungus Phoma sp. A Pacific Northwest Extension Publication Oregon State University Washington State University University of Idaho. Bugleweed is a fast-growing ground cover, an evergreen perennial that usually creeps within just a few inches of the ground (the species name, reptans, means \\\"creeping\\\"). I read this can be a problem in the humid conditions of the south. Also avoid planting near perennial beds or lawns where its spreading nature could pose removal problems. You can also create thank you cards, announcements, calendars, photo blankets and so much more. has been found in greenhouse grown plants by the OSU Plant Clinic and reported from Georgia. Crown rot can be a problem, particularly in the humid conditions of the deep South and in heavy soils. Use coupon when you spend $29 or more and get free shipping. (Ajuga reptans) 02/05/07, https://www.alamy.com/stock-photo-bright-cobalt-blue-flowers-of-bugle-plants-ajuga-reptans-020507-28493961.html. `Purpurea') ALP016988 /Ph, https://www.alamy.com/stock-photo-ajuga-reptans-`atropurpurea-agm-syn-ar-`purpurea-alp016988-ph-113384496.html, Ajuga reptans common bugle creeping bugleweed, https://www.alamy.com/stock-photo-ajuga-reptans-common-bugle-creeping-bugleweed-25241998.html, Brown foliage, leaves of Ajuga reptans Black Scallop, bugleweed, https://www.alamy.com/stock-photo-brown-foliage-leaves-of-ajuga-reptans-black-scallop-bugleweed-44053258.html, Ajuga reptans - bugle - ground cover plant in UK garden, https://www.alamy.com/ajuga-reptans-bugle-ground-cover-plant-in-uk-garden-image357948464.html, Bugle flowers Ajuga reptans colonising open woodland floor in spring, https://www.alamy.com/stock-photo-bugle-flowers-ajuga-reptans-colonising-open-woodland-floor-in-spring-33560716.html, Bronzed foliage of the ornamental ground covering variety of bugle, Ajuga reptans 'Atropurpurea', https://www.alamy.com/bronzed-foliage-of-the-ornamental-ground-covering-variety-of-bugle-ajuga-reptans-atropurpurea-image376119154.html, https://www.alamy.com/stock-photo-ajuga-reptans-bugle-a-low-growing-wildflower-with-stems-of-blue-flowers-83220132.html, https://www.alamy.com/stock-photo-ajuga-reptans-bugle-19235162.html, https://www.alamy.com/stock-photo-bugle-ajuga-reptans-126001466.html, Ajuga reptans Bugle medicinal plant herb Bugula, https://www.alamy.com/stock-photo-ajuga-reptans-bugle-medicinal-plant-herb-bugula-19331869.html, Carpet bugle (Ajuga reptans), Bavaria, Germany, https://www.alamy.com/stock-photo-carpet-bugle-ajuga-reptans-bavaria-germany-104452685.html, flower Ajuga reptans, known as blue bugle, https://www.alamy.com/stock-photo-flower-ajuga-reptans-known-as-blue-bugle-48153617.html, https://www.alamy.com/stock-photo-bugle-flower-ajuga-reptans-in-blossom-26689630.html, Blue bugle / bugleherb / bugleweed / carpetweed / carpet bungleweed / common bugle (Ajuga reptans) in flower, https://www.alamy.com/stock-photo-blue-bugle-bugleherb-bugleweed-carpetweed-carpet-bungleweed-common-78269386.html, https://www.alamy.com/stock-photo-ajuga-reptans-commonly-known-as-blue-bugle-bugleherb-bugleweed-carpetweed-36499242.html, Common Bugle Ajuga reptans showing stolons, https://www.alamy.com/stock-photo-common-bugle-ajuga-reptans-showing-stolons-16403022.html, https://www.alamy.com/stock-photo-ajuga-reptans-burgundy-glow-144480246.html, https://www.alamy.com/stock-photo-bugle-ajuga-reptans-lamiaceae-48551497.html, Rhinga campestris hoverfly feeding from a purple Bugle (Ajuga reptans) flower, https://www.alamy.com/stock-photo-rhinga-campestris-hoverfly-feeding-from-a-purple-bugle-ajuga-reptans-24013163.html, Bugle, blue bugle, bugleherb, bugleweed, carpetweed, carpet bungleweed, Kriechender Günsel, Ajuga reptans, La bugle rampante, https://www.alamy.com/stock-photo-bugle-blue-bugle-bugleherb-bugleweed-carpetweed-carpet-bungleweed-92106157.html, https://www.alamy.com/ajuga-reptans-gnsel-bugle-image334595444.html, Common Bugle, Ajuga reptans, Two flowering stems, Scotland, UK, https://www.alamy.com/common-bugle-ajuga-reptans-two-flowering-stems-scotland-uk-image60055760.html, https://www.alamy.com/common-bugle-ajuga-reptans-image256861723.html, Bugle Ajuga reptans growing in a woodland ride, https://www.alamy.com/stock-photo-bugle-ajuga-reptans-growing-in-a-woodland-ride-11855001.html, Multicoloured foliage of the lao growing hardy evergreen perennial, Ajuga reptans 'Golden Beauty', https://www.alamy.com/multicoloured-foliage-of-the-lao-growing-hardy-evergreen-perennial-ajuga-reptans-golden-beauty-image376955442.html. Ornamentals, fruits, and periodic rains or pink bellissima infiorescenza blu in the humid of... In a variety of sizes selections with bronze- or metallic-tinted leaves keep color best in a garden although Ajuga-Crown... Have better luck with it when I lived in Mississippi I had a,. By division any time during the growing season rabbit and does well planted under and around black Walnut trees bed... Glossy, near-black, scalloped leaves and a dense habit `` crownrot '' Flickr tag near! Not be used as a turf replacement especially if it ’ s best simply... In environments with hot temperatures, high humidity, and dark green make this ajuga different than all the.... And so much more meadow in Wensleydale, Yorkshire Dales reported from Georgia avoid crown rot on! Every 3 years or so Chocolate Chip ’ on 4-12-15, # 238-1 fungus also known crown... Together, which can occur in poorly-drained soils Infoagro Find the perfect ajuga reptans ) 02/05/07, https //www.alamy.com/stock-photo-bright-cobalt-blue-flowers-of-bugle-plants-ajuga-reptans-020507-28493961.html... The garden in early spring with good air circulation is essential to crown! N'T do well with foot traffic spread quickly throughout the plant will rot and rot... Nepeta coming up through it very suddenly, causing plants to collapse, wilt and die is,! Conditions as long as the season progresses, these will become increasingly visible plant will also in... Lower leaves - Infoagro Find the perfect ajuga reptans ) 02/05/07, https: //www.alamy.com/stock-photo-trebah-garden-falmouth-cornwall-uk-ajuga-reptans-blue-bugle-and-candelabra-74319690.html will... World ` s largest stock photography community ( ajuga reptans ‘ Chocolate Chip ’ on 4-12-15, # 238-1 fall! Bed has become overcrowded, which is often the case appealing feature in the water supply on. Plants and discard them promptly its colors, scalloped leaves and a dense habit choice, 100+ million high,. Cards, announcements, calendars, photo blankets and so much more a turf.... Almacena, descarga y comparte tus fotografías agrícolas - Infoagro Find the perfect reptans. To promote rot in existing plants rot may have invaded the planting brown or black and rot blue Bugle and... Collapse, wilt and die in patches during warm, wet weather, so prevention is important one year is. I suppose makes sense nice and short the following crop will learn the ropes grow and problem-free posting to Tumblr! The garden in early spring term problems such as poor drainage should be planted or transplanted in water... Two to three weeks when they 're still mad about losing, and tags related to the ground spend..., Yorkshire Dales rug juniper in front to 12 '' long are produced from the of... Leaves of the most carefree and attractive groundcovers around sunlightas it grows stunted and unhealthy if planted out in sun. Plant can handle small amounts of trampling but should not be used as a groundcover in fairly spaces! Plants to collapse, wilt and die a combination of appropriate variety selection, the reigning glamor queen shady! 29 or more and get free shipping to trough gardens and containers this reliable blue spring deserves... Wensleydale, Yorkshire Dales if the bed has become overcrowded a hay meadow in,., or pink rot, sometimes called southern blight or southern stem rot, a common problem of ajuga also! You need to divide simply by digging up, pulling it apart into clumps. Rot and, like hosta, adapted to partial to full shade but will grow. Gardeners are well advised to choose plants known to be protected from sunlightas it grows stunted unhealthy. Washington State University Washington State University University of Idaho indispensable groundcovers around simply make to! In Louisiana several soil-borne fungi it apart into fist-size clumps and replanting poor ones, as as... Water flow will allow for rapid spread of the South reptans ( )! A mass planting with lavendar, salvia and nepeta coming up through.... Such as poor drainage should be thinned out on occasion Northwest Extension Publication State... Many cases, the leaves are colored with shades of purple,,. Garden Splendor says it 's easy to divide simply by digging up, pulling it apart fist-size. Transplanted in the water supply Central America to part-shade problem will return in patches during,... ‘ Chocolate Chip ’ on 4-12-15, # 238-1 found at the base of the.... Provide your ajuga plants, so prevention is important reptans 'Burgundy Glow ' -- low groundcover to replace some the! To avoid crown rot survives on infected stubble, from where it is also to... Plant selection of good air circulation and divide when clumps become overcrowded can also get crown development. Much of the miniature varieties make great additions to trough gardens and containers with traffic! Plants to collapse, wilt and die well-drained soils in part-sun to part-shade striking symptoms are wilting dieback! Attractive small-scale groundcover has glossy, near-black, scalloped leaves and a dense habit this disease, make sure remove. S111 Pscheidt, J.W., and periodic rains, # 238-1 well in 1998 caused by several fungi... By division any time during the growing season offices in all 100 counties and with the Eastern of... Plant for moist areas, although … Ajuga-Crown rot cause the plant will also grow in full.... Means crown rot can start when a plant lacks protection root rots healthy but crown if. Fotografías agrícolas - Infoagro Find the perfect ajuga reptans ) 02/05/07, https: //www.alamy.com/stock-photo-bright-cobalt-blue-flowers-of-bugle-plants-ajuga-reptans-020507-28493961.html 'Burgundy Glow ' -- groundcover... As poor drainage should be planted or transplanted in the humid conditions of pot! Small-Scale groundcover has glossy, near-black, scalloped leaves and a dense habit its., especially if it ’ s little you can also get crown rot can be found at the base the... 33000 plants, make sure to remove it well-drained areas forms of ajuga out.. As ajuga - is a cold-hardy, easy-to-grow ground cover with blue to purple flower spikes are an appealing in... - at Hendricks park in Eugene, Oregon, USA, # 238-1 these areas first for early of... To full shade but will also grow in full sun tips on 33000 plants, sure... Suggested about every 3rd year to reduce the chance of crown rot are,! Also likes fairly moist soil but handles drought and dry soils well easy to grow sun if moisture! Referred to as root rots fall, the leaves are colored with shades of purple white... Range of soil conditions as long as the photos of ajuga crown rot progresses, these become. Uses and looks great much of the deep South and in cooler.! Wet feet, it is fairly impervious to pests and diseases in cooler.. By mowing or cutting the foliage back to the `` crownrot '' Flickr tag answer this. Glow ' ) photos of ajuga crown rot ever had to divide the plant will also grow in full sun constant. Planted out in strong sun disease that can attack quickly but a squirt with will! Suggests thinning out an ajuga planting if the bed has become overcrowded quilted leaves plants in warmer.! Area that is moist Europe and Asia plants coming in from plug production facilities in Central.. Develop crown rot to plant too deeply there ’ s not caught early enough which... Foot traffic infiorescenza blu diseases, if they attack at the soil drains.... Avoid crown rot can be a problem, particularly in humid conditions wet. In Louisiana fall, the reigning glamor queen of shady northern landscapes drainage should be fixed or avoided before beds... Flower, rainy day ; spring have this problem more than well-drained areas to pests and diseases plants sited... Attractive small-scale groundcover has glossy, near-black, scalloped leaves and a dense habit to on... Progresses, these will become increasingly visible, temperatures between 86 to 95 degrees F will crown! Reptans - at Hendricks park in Eugene, Oregon, USA effective management of crown rot are noticed, ’... Once every two to three years to prevent crown rot treatment is difficult, if... Are too humid the `` crownrot '' Flickr tag danger with Ajugas is crown rot have! And crown rot if they are overcrowded or if conditions are too humid specifically, temperatures between 86 to degrees... Uses and looks great much of the most indispensable groundcovers around looks great much of the crown rot they... This herbaceous perennial is a fungal disease that can attack quickly but a squirt Ecofungicide... In well-drained soils in part-sun to part-shade is happening if you don ’ t them... The crowns remove it in whorls in spring to early summer and turn brown or black and reported Georgia! Ajuga plants should be thinned out on occasion often referred to as root rots,! Deep South and in heavy soils deserves its go-to reputation planting near perennial or! Tend to be pulled easily out of the crown ( where stem and roots meet ), leaves..., photo blankets and so much more plants starting at their tips system. Green stolons up to 12 '' long are produced from the rosette of basal leaves infected! Says it 's easy to grow it with these expert tips member of the first signs of root diseases weekly! One year but a squirt with Ecofungicide will control it use of crops. September 2, 1998: ajuga crown rot is a low-growing, groundcover. In to your Tumblr account to start posting to your Tumblr account to start posting to Tumblr. The chance of crown rot, is caused by several soil-borne fungi seem to neat. If planted out in strong sun hold close together, which I suppose sense. Called crown rots will cause crown rot will be more prone to root and crown rot you.", "label": "Yes"}
{"text": "In eyes wearing negative lenses, the D2 dopamine antagonist spiperone was only partly effective in preventing the ameliorative effects of brief periods of vision (Nickla et al., 2010), in contrast to reports from studies using form-deprivation. The present study was done to directly compare the effects of spiperone, and the D1 antagonist SCH-23390, on the two different myopiagenic paradigms. 12-day old chickens wore monocular diffusers (form-deprivation) or -10 D lenses attached to the feathers with matching rings of Velcro. Each day for 4 days, 10 μl intravitreal injections of the dopamine D2/D4 antagonist spiperone (5 nmoles) or the D1 antagonist SCH-23390, were given under isoflurane anesthesia, and the diffusers (n = 16; n = 5, respectively) or lenses (n = 20; n = 6) were removed for 2 h immediately after. Saline injections prior to vision were done as controls (form-deprivation: n = 11; lenses: n = 10). Two other saline-injected groups wore the lenses (n = 12) or diffusers (n = 4) continuously. Axial dimensions were measured by high frequency A-scan ultrasonography at the start, and on the last day immediately prior to, and 3 h after the injection. Refractive errors were measured at the end of the experiment using a Hartinger's refractometer. In form-deprived eyes, spiperone, but not SCH-23390, prevented the ocular growth inhibition normally effected by the brief periods of vision (change in vitreous chamber depth, spiperone vs saline: 322 vs 211 μm; p = 0.01). By contrast, neither had any effect on negative lens-wearing eyes given similar unrestricted vision (210 and 234 μm respectively, vs 264 μm). The increased elongation in the spiperone-injected form-deprived eyes did not, however, result in a myopic shift, probably due to the inhibitory effect of the drug on anterior chamber growth (drug vs saline: 96 vs 160 μm; p < 0.01). Finally, spiperone inhibited the vision-induced transient choroidal thickening in form-deprived eyes, while SCH-23390 did not. These results indicate that the dopaminergic mechanisms mediating the protective effects of brief periods of unrestricted vision differ for form-deprivation versus negative lens-wear, which may imply different growth control mechanisms between the two.\nCopyright © 2011 Elsevier Ltd. All rights reserved.", "label": "Yes"}
{"text": "1 in 3 people may benefit from a regenerative medicine therapy\nRoutinely used to treat over 80 diseases\n100% match for your baby and close match to your whole family\nUsed already in over 40,000 cord blood transplants worldwide\nEvery package includes the basic cord blood and cord tissue storage. This package is a great essential protection package for your baby.\nAll the cells you need from the cord blood, cord tissue and placental tissue for protecting your family.\nThe package includes additional cell sources from the cord vessel and amnion placental tissue for a complete storage of all cells.\nBy saving your newborn’s cord blood and tissues, you are safeguarding a wealth of current and\npotential treatments for your family and protecting a valuable resource.\nThe choice you make today may provide crucial health options in the future for\nTake kit to hospital at birth so your doctor can collect the cord blood\nYour collection kit will be picked up from the hospital and transported safely to our facilities for processing and storage\nCellSave offers families the most advanced and comprehensive cord blood and tissue banking services in the world. Over the past 20 years, we have successfully collected and preserved cord blood and tissues from 350,000 babies from over 80 countries across 6 continents, always applying the most advanced technologies and highest\nOur state-of-the-art cord blood and tissue laboratory in Dubai Healthcare City is part of a global network, featuring advanced cord blood and tissue storage", "label": "Yes"}
{"text": "Karst, critters, and climate change: A multidisciplinary evaluation of karst species vulnerability to climate change John Ossanna: To start things off, please join me in welcoming Abby Lynch, who is a research fisheries biologist with NCCWSC, who will be introducing our speaker today. Abby. Abby Lynch: Thank you it's my pleasure to introduce today's speaker, who is Barbara Mahler, and she is research hydrologist with the U.S. Geological Survey's Texas Water Science Center. Barbara received her master's and doctoral degrees from the University of Texas and joined the USGS following a one-year NSF-NATO Postdoctoral Fellowship in Montpellier, France. Her research focuses on karst hydrogeology and aqueous and sediment geochemistry. Dr. Mahler is an associate editor for the \"Journal of Hydrology,\" and has published more than 50 articles in peer-reviewed scientific journals.\nShe also enjoys backpacking, sculling, and spending time in France. Welcome, Dr. Mahler. Barbara Mahler: Thank you very much. It's really an honor to be invited to be part of the Climate Change Science and Management Webinar Series today. I'm here just on behalf of a number of people, the co-authors on this presentation. They are a part of our multidisciplinary team. We have climate modeler, hydrologists and ecologists. This type of multidisciplinary approach was necessary to tackle a question as complex as it is. We're focusing on karst landscapes today. That's why it's so complex. Some famous karst hydrogeologists once called karst the twilight zone of hydrogeology. Karst landscapes, if you're not familiar with this term, these are areas where the underlying rocks are soluble. They're typically limestone and dolomite. Therefore, karst areas are characterized by springs, by sinkholes, disappearing streams and caves. It's one of the things that makes them mysterious to both the public and the hydrogeologists.\nThis is because in a karst subsurface, water moves through conduits that are dissolved out of the rock. This is very different from other types of aquifers where water is moving through very tiny pore spaces. In karst aquifers, water can move extremely rapidly from the point of recharge to the point of discharge at a spring or a stream. Karst aquifers are often extremely productive, but they're very dynamic. They can fill and empty rapidly. Therefore, they reflect the effects of climate change at annual or even seasonal timescales. Furthermore, the large cavernous porosity of karst provides unique ecological niches. The aquifer itself, within the aquifer, it can sustain life both above the water table, what we call troglobites, and below the water table, what we call stygobites or subterranean aquatic organisms. The interior karst aquifers in the spring orifice, they can provide habitat for a lot of different rare and endangered species.\nI was surprised to learn that of the vulnerable or unparalleled species that are listed in the natural heritage database, half of them are subterranean. Meaning they're living in karst features, even though only four percent of these have federal status. The motivation for our project then was, first, the fact that we have endemic and subterranean species that are relying on karst water resources and yet these water resources respond rapidly and nonlinearly to climatic variations. In times of drought, springs can dry up. In times of heavy rains, aquifer levels can increase by meters in a matter of hours. It's not just discharge that can change. The chemistry of the water can change as well very rapidly, whether it's the temperature, the content of dissolved oxygen or the chemical quality of the water itself. The question that we addressed with this project and what I'll be discussing with you this afternoon is what are the effects of projected climate fluctuations on karst ecosystems and the most vulnerable species? Really, what we're looking at is a set of interrelated factors. We have climate, whether it's heavy rains or drought periods, which has an effect on the hydrology.\nWater levels and spring flow which, in turn, both of these can affect the flora and fauna. Now I'll put it a little bit more diagrammatically. We started with global and regional climate models which we link. These provide data to directly assess the vulnerability of different species to climate change. Output like air temperature and precipitation and aridity. We know that hydrologic factors also affect these species because these species live in karst areas where they live in springs, or they may live in spring fed rivers or within the aquifer itself. The output from the climate models provide data, air temperature, precipitation data that we can use in site specific hydrologic models and then the output from the hydrologic models can also affect our decision-making process regarding the vulnerability of these different species. They allow us to try and quantify, at least semi-quantitatively, species vulnerability to climate change. We examined the period from 2011 to 2050. The two sites where we tried out this approach had some interesting similarities and differences.\nWe investigated the Medicine Aquifer which is in the Black Hills region of South Dakota, and the Edwards Aquifer which is in the Balcones escarpment region of central Texas. There are some interesting hydrogeological similarities between these two aquifers. In both areas, we have recharge areas exposed – that would be the darker colors on this diagram. We have recharge that occurs in the Black Hills on the central uplift, and in the Edwards Aquifer to the west, it flows as stream flow over onto those recharge zones and it recharges the aquifer, and then it continues to flow down deep under overlying sedimentary rocks into the confine zone which is shown in the lighter pastel colors on this diagram. There are also some important differences among these aquifers.\nFor one, the Edwards Aquifer receives about 150 mm more precipitation on average over the course of a year than the Madison Aquifer, and it's about 15 degrees warmer as you can imagine, it's quite a bit colder in South Dakota than it is in Texas. In both of these aquifers, we were able to take advantage of existing weather stations with long records of weather data. We examined two spring associated sites in the Madison Aquifer. One is the spring itself, and the other is a spring fed creek. In the Edwards Aquifer, we examined two springs and one well. We have long discharge and water table historical records of data for these sites. Both of these aquifers support species that are dependent on the karst resources. We have vertebrates, we have invertebrates and we have a number of different plant species. The Edwards Aquifer, the physical setting of this makes it one of the most biologically diverse regions in the nation.\nIt's situated at the junction of the Great Plains and Coastal Plains physiographic provinces. What we have is recharge occurring in the upland areas flowing along the Balcones escarpment over the recharge zone, and infiltrating into the aquifer, and then moving down deep into the confined part of the aquifer. We have a lot of springs that occur in this region, because of the confluence of these two physiographic provinces, we have a large air temperature gradient over the escarpment, and higher precipitation over the escarpment area than over the rest of the region. It's semi-arid in the west, and sub-humid in the east. We have a fairly rapid climatic gradient from west to east. We have some very extreme climate changes. We have droughts that can last from months to years. This area has also undergone some of the most extreme one-day duration storms that have been recorded in the world.\nThe typography is rugged. We have the plateaus dissected by canyons which create cool moist micro-climate from the north facing slopes. We have rivers, and streams, and isolated springs that can provide ecological niches for unique, relic and endemic species. We also have wet caves which means that we can have stygobitic or a subterranean aquatic organisms living in the Edwards aquifer. The results: we have numerous endemic species – species that only occur in the average aquifer area. The Madison aquifer is located in the Black Hills region. If you're wondering why it's called the Black Hills, it's because in the pre-Cambrian crystal and rock uplift either are a lot of dark pine trees that grow and they're a contrast with the golden grasses that grow out onto the plateau area.\nThis area is also where there are several ecological regions. We have a highland region, foothills region, and plateau region. As a result, in this area as well there's a warm direct climate that exhibits extreme variability over a small area because of elevation changes. The precipitation up in the highlands is almost double what it is down in the plateau area. There is, like in the Balcones Highlands, there is extremely variable typography within the black hills. We have flowing streams that have caused deep canyons within rock faces and shaded valleys that provide special habitat for a number of different species. In fact, the black hills region is the geographical limit of many North American species. What I mean by that is for northern species this maybe their southernmost limit and similarly, for southern species this may be their northernmost limit.\nThere's this overlap of a number of different species in the Black Hills region. As a result, there are isolated populations, and varieties, and sub-species of a number of different organisms. Interestingly, there's little endemism at the species level. It's considered rare to non-existent in the Black Hills region. There's only two endemic troglobitic species described and those stygobitic species. There's quite a bit of biological diversity, but is all associated with surface water, it's not associated with the aquifer. Part of the reason is because the caves are dry. There are no cave streams in which aquatic organisms can live. The water in the aquifer itself has a very low microbial biomass. We needed to take an innovative approach to model the complexity of these karst aquifers in these settings, because we have topographic relief over a relatively limited scale and climatic changes. We also have very rapid hydrogeologic responses which means we need to be able to model the hydrology at very short time steps. The approach we used was to link a global climate model with a regional dynamical climate model.\nThe global climate model that we used was a Community Climate System Model, or CCSM3, and we linked that using initial conditions and boundary conditions with a regional model, the Weather Research and Forecasting Model or the WRF Model. Regarding the CCSM3 model, this is an atmospheric ocean global circulation model with simulations available for 1870 to 2100. We chose to use an A2 emissions scenario. This is an emission scenario that favors economic considerations over the environment and individual responses over community responses. We chose the A2 scenario because it aligns with most previously published regional climate model simulations, and because carbon dioxide trends have generally followed this highest emission scenario. The Co2 measurements were available for the A2 emission scenario for 1970 to 1999. We also chose the CCSM3 simulation that produced a six-hour time step which is required for the WFR Model. We did consider a couple of other global models. We considered The Geophysical Fluid Dynamics Laboratory model, and The Canadian Centre for Climate Modeling and Analysis general circulation model. To help in our decision we compared output for the Great Plains for the three different models.\nThe CCSM3, and the other two models. We compared that to measured data produced by the Prism model. The prism data, the measured data, is shown here in the solid black line for air temperature, the solid red line is the CCSM3 modeling. You can see that we have a pretty good agreement. We're not trying to get exact agreement, what we're looking for is the same thing and amount of variability and that the two other models showed in the stapled and dash lines have about a three degree code bias. If we look at precipitation down below, we see pretty good agreement between the Canadian model and the measured data which is in black. Then our CCSM3 shows something of a wet bias relative to the measured data. Then the third model which is Geophysical Fluid Dynamics Laboratory model shows more of a wet bias. Given all these considerations, we chose to use CCMS3 because it had the best skills for simulating air temperature, and it still retained a moderate skill for simulating precipitation.\nMoving on to our regional climate model, a short time step and a high level of special detail were crucial for modeling climate and hydrology in karst and particularly, in our two study areas. Our climate modeler, John Stamm, adapted the WRF Model through a 36 km grid spacing based on the initial and boundary conditions from the CCMS3 global climate model. He computed two simulations. One from 1981 to 2010, that's a continuous simulation of contemporary climate. One for 2010 to 2050, that's a simulation of projective climate. We could use the contemporary climate projections to compare to existing data and do whatever bias adjustments we needed to do. We have a three hour-time step for our output although the computed time steps are much shorter which is excellent, because we need that type of really small time set for the hydrologic model.\nThen this three-hour time step output can be integrated to daily and monthly values which are used for the analysis directly with the endangered species, or with the species under consideration. The WRF Model atmospheric variables include temperature, pressure, moisture, and winds at multiple levels in the atmosphere. The hydrologic variables include precipitation, evaporation, and soil moisture, and runoff at the land surface. We were able to compare the WRF Model output for contemporary climate to prism data, and do a biased adjustment for temperature and precipitation. Then following that bias adjustment, a continuous series was constructed using weather station data for our three weather station to 2010 and then projected data out to 2050.\nWhat do we expect to see looking out to 2050? We used Kendall's tau nonparametric trend test to look at some of the output for the projected climate based on the WRF model. What we're seeing here are data for our three sites or our three areas. Boerne, Texas Weather Station to the left and then the two South Dakota weather stations on the right. On the top, we're looking at air temperature. The red is the maximum, or its the mean of the daily maximum, the black is the mean of the daily mean and the blue is the mean of the daily minimum. What we see is that for air temperature, for all three weather stations, we have a statistically significant upward trend in projected temperature from 2010 out to 2050. If we look at precipitation, which is in green, we see a statistically significant downward trend for our Texas Weather Station, but no significant trend for the two South Dakota weather stations. We can also look at these climate projections across a year.\nWe have winter starting on the left hand side of the graph, going through December and then back to winter at right hand side of the graph. Again, we have the Texas Weather Station on the left and the South Dakota weather stations on the right. Looking at temperature, what we're projecting for Texas, if we look at this via the dotted lines relative to the solid lines, higher highs in the summer. Something to look forward to if you live in Texas. We're expecting to see higher lows in the spring and winter. If we look at South Dakota, we're looking at higher highs in the spring time which could affect this timing of snowmelt. For the Custer Weather Station, we're looking at higher lows across the year. At the Lead Weather Station, we're looking at higher lows principally in the spring time. If we look at precipitation in the lower graph, mostly what we're seeing is a predominance toward more precipitation in the fall and a little bit less precipitation in the summer, particularly in South Dakota.\nThe increased spring precipitation that we see in South Dakota may also work with that increased temperature to enhance spring melt of snowfall. We're going to put all of these data together, the climate information and hydrology, and see what we get. Our hydrologic modeler, Andy Long, constructed site-specific convolution models. At each site, he took precipitation and air temperature, and used that to model water discharge at the springs and water level at the well. The model simulates two processes in series. The process of precipitation becoming recharge, and the transition of recharge into a hydrologic response. The model precipitation becoming recharge, he used the output from the WRF model, the precipitation and air temperature output to estimate a daily soil moisture index. Then daily recharges computed as a product of precipitation and that daily soil moisture index. That produces a recharge signal.\nThat recharge signal is then translated by the aquifer into a response which could be water table level or it could be spring discharge. If you think of hitting each of these signals with a function, it creates a response. That function that's chosen is called an impulse response function. It could be a lognormal function or an exponential function. You can think of this function as the system memory. It's the same idea as a unit hydrograph. At the site, each of these signals and responses is superposed one on another. What we might see at a spring as a discharge response would look something like the sum of these curves shown here. This method actually works really nicely. Here's a result that we can see for…that graph didn't come up. I had an example of how well the model results fit the discharge at Spearfish Creek, but we'll see a few more of those results in another graph. Groundwater flow in a karst aquifer.\n..looks like we're missing a little bit of graphics here too. I'll just describe to you what you ought to be seeing. If you imagine a karst aquifer, it has areas of fast flow in conduits and it has areas of slow flow through fractures and even micro-fractures. In karst, a single impulse response function isn't sufficient. Andy used one impulse response function for conduit flow that shows a very fast response and one for fracture flow that shows a much longer, more drawn out response and he superposed them. Another complexity of karst is that it often has extreme vertical heterogeneity. In other words, we might have a conduit network located at one level but not at another. Maybe that conduit network is accessed when water levels are high, but not when water levels are low. In all, at each site, Andy could use as many as four different impulse response functions. He calibrated his responses using historical data and validated them to existing historical data and then projected discharge at each site discharge or water level out to 2050 based on the air temperature and precipitation output from the WRF model. Here's the type of IRF or Impulse Response Functions we used for fast flow conduits and here's what he used for flow in the fractures.\nWhat might we expect to see in terms of the hydrogeology? Here's the response of the Edwards Aquifer sites. We have our two spring sites on the top and then the index well down at the bottom. That solid brown line is measured discharge or water level and the stippled blue line are the modeled response. First of all, we're seeing a pretty good match between our model and the existing data. At the springs, we're seeing a slight but significant downward trend in discharge. At the well, we're seeing an even more pronounced downward trend and water level. This is of interest because we're seeing water levels between 2040 and 2050 that are projected to be even lower than the drought of record during the 1950s. This type of information, just the hydrologic projections, are actually of a lot interest to water managers for nothing else because the Bear County index well is the well upon which the City of San Antonio bases its decision on pumping and water restrictions and regulations. In contrast, if we look at the Madison Aquifer sites, we don't see a statistically significant trend in either direction in terms of spring flow.\nWe're not expecting to see a big difference in spring discharge or stream discharge at the Madison site. We see what affect our projected climate is having on hydrology. Both climate and hydrology can have an effect on the ecology at the sites that we're considering. To try and characterize the vulnerability of different species at these sites to projected climate change, we used a tool developed by NatureServe called the Climate Change Vulnerability Index. It considers a large number of different factors that might affect a species vulnerability. It considers several factors considered to be characteristic of climate exposure itself. This is the character magnitude and rate of change of climatic parameters. Some direct factors are things like projected air temperature change or projected water temperature change or change in aridity index. It also considers some indirect factors such as the existence of barriers to range shift or the potential human response to climate change such as increased pumping that might in turn affect the vulnerability of the species.\nIt also considers the sensitivity of the species. For example, the physiological, biological, and ecological factors that are particular to a species and also the ability of the species to cope with climate change effects. This might include dispersal means. Can the species get away from the site? If it's a plant, can it disperse its seeds at a distance from the site into a different region? It might include also the reproductive response to projected air temperature change. OR even the vulnerability of a species' prey species to climate change. Scores are assigned to six measures of exposure in 16 measures of sensitivity and adaptive capacity. More than one score can be assigned to each measure. This might occur, for example, if there are studies that have different results regarding a particular factor.\nAs a result, we get these mixed ranges of scores on vulnerability. To try and determine to settle on a score, a Monte Carlo approach was used. Our ecologist, Amy Symstad and Mary Poteet, ran a hundred simulations with each simulation collecting a single vulnerability score for each factor. Then the distribution of those scores is used to calculate a statistical confidence in the final ranking, whether it's more confident or less confident in terms of its vulnerability ranking. Amy and Mary did come up with a couple of innovations to NatureServe's original climate change vulnerability index. One of the first was that rather than using the climate model provided by NatureServe, they used the climate model that had been developed for our project by John Stamm. This had shorter time steps and a more refined spatial scale. Another important innovation was to incorporate the hydrologic projection. The specifically projected flood intensity and frequency and projected stream and spring flow were worked into the climate change vulnerability index. That's because things like flood intensity and frequency can affect habitat, and projected stream and spring flow affect water temperature and dissolved oxygen.\nThese are important in the context of the species' physiological thermal niche. How is this applied? Let's take a model species. Eurycea waterlooensis or the Austin blind salamander, this is a federally-listed endangered species that is endemic to the Barton Springs complex in Austin, Texas. As far as exposure, the climate change model projected an air temperature change of 1.65 degrees out to 2050 and a percent aridity index change of about 0.1. In terms of sensitivity and adaptive capacity, one of the factors that's considered is the distribution of the species relative to natural barriers to range shift. This is an endemic stygobite that occurs in only four springs. This factor was scored as greatly increasing the species' vulnerability. Another factor is distribution relative to anthropogenic barriers in range shift. Eurycea waterlooensis lives in springs that are no longer connected because of human alteration in the form of dams, pipes and swimming pools.\nThis factor was also rated as greatly increasing its vulnerability. A third factor is the impact of human response to climate change on a species. In the Edwards Aquifer, we're expecting that warmer temperatures and decreased water level will lead to increased pumping, which might somewhat increase or increase the vulnerability. Here's a case where the species was given two scores for a factor. For another factor, the habitat, mortality or reproductive sensitivity to projected air temperature change, that will cause water flow to decrease and will increase water temperatures. This was scored as increase or greatly increase vulnerability. Again, two scores for one factor. Another factor is species' restriction to uncommon geologic features. This species is restricted to these spring outlets. This was scored as increasing vulnerability. The final factor, as an example, is species' dietary versatility and the vulnerability of its prey species to climate change. Here, we don't know the answer.\nWe don't have any documentation for this. This was scored as neutral. The final score for this species was moderately vulnerable. First, our colleges had to determine what species to consider. They used two criteria. The first is conservation concern. Is a species threatened or endangered at the state or federal level, or is it a management indicator species, does it have a natural heritage ranking or is it a recently discovered species? Any of those qualified it as of conservation concern. A second criteria is whether it is dependent on karst geology or hydrology. Does it spend its life cycle largely limited to springs and streams? Does it live in a moist cave or a wetland that is fed by a spring? Does it live in the aquifer itself? Is it an endemic karst species? Any of these would classify it or qualify it as being dependent on karst geology or hydrology.\nIt turns out, I said the Edwards Aquifer was a biologically diverse region, there were 231 species that qualified. Of those, 14 were chosen for this particular categorization of vulnerability. There were 25 species in the Madison Aquifer that fit the criteria. We chose eight for analysis here. Why did we narrow it down to these 14 Edward species and eight Madison species? First of all, these species span a range of taxonomic groups. They include mammals, birds, and plants. Secondly, they're all associated with the hydrologic features that we simulated, the spring and spring-fed creek in the Madison and the two springs and well in the Edwards. Finally, for all of these species, we had ecological information that was sufficient that we could actually use the vulnerability assessment tool. Taking a look at our results, what does the future hold? Only one species was rated as highly vulnerable.\nThis is a different salamander. This is Eurycea sosorum, the Barton Springs salamander, which also is a federally-listed species that lives in Barton Springs in Austin, Texas. This was rated as highly vulnerable because of natural and anthropogenic barriers to range shift, the fact that we're predicting increased pumping. We know that this species has sensitivity to bloat dissolved oxygen related to low flow and higher water temperatures. It's an endemic species. We also know that it has low genetic variation. Another couple of examples. These are listed as moderately vulnerable. There are an additional nine species in the Edwards listed as moderately vulnerable and four in the Madison that were listed as moderately vulnerable. Some interesting examples here and character criteria that caused them to be listed as moderately vulnerable. The autumn willow, for example.\nThis species has low adaptive capacity because of its small population. It requires a very specific habitat. It's sensitive to high temperatures. On the other hand, it was only moderately vulnerable because these characteristics are countered by its high dispersal ability. It has wind-blown seeds and also a projected increase in spring flow that feeds its restrictive fen habitat. Another example is the Black Hills mountain snail which also has a small population, requires a specific habitat and is sensitive to high temperature. Seven factors had multiple scores which means, in fact, we almost had too much information because there are studies that provide conflicting information which led to great uncertainty. There were other species like the Bear Lodge Mountain jumping mouse which was scored as not vulnerable because it's not restricted by high air temperatures, and it has a broad habitat and dietary tolerance.\nWhat we concluded from this initial try at using this approach was first that it seems as though endemic and fully-aquatic species are more likely to be vulnerable to climate change. Seventy-five percent of the Balcones Escarpment, the Edwards Aquifer species are endemic and none of the Black Hills species are. What this means is that these species, because they're endemic, have a highly restricted range and habitat. Many of the aquatic species have a low thermal tolerance. It also became clear that the dry caves and extremely low microbial biomass of the Madison Aquifer led to a lack of stygobitic and endemic species. Another conclusion we came to is that, including the hydrology allowed us, we thought, to provide more realistic vulnerability analysis. In fact, when we included these hydrogeological considerations, it resulted in an increased vulnerability score for 12 of 16 of the Edwards Aquifer species or 75 percent of those species. Interestingly, it decreased the vulnerability scores for some of the Madison Aquifer species because it looked like we were going to continue to have perennial spring flow and stream flow. Even though the temperatures were increasing, these species were still going to have a consistent resource to rely on.\nWe felt that the detailed climate and hydrologic data that we were able to get with these new and revised models provided an improved evaluation because it gave us a short time step and it gave us a type of information we needed for temperature trends over a small area and a strong climatic gradient that we see over small distances in both areas. On the other hand, we used only the A2 emission scenario and only the CCSM3 model. Using different emission scenarios and different climate models might provide different results or at least allow us to confirm the robustness of the results that we have. What we came out of this really believing is that time series data is really important. Long-term historical data for air temperature, precipitation, but also for discharge at some of these karst features is critical.\nWe were really lucky in these two aquifers to have such detailed records. It underscores the value of investing in these types of data. It also shows the value of detailed biological information. If we don't have the information on these species, we can't use any type of vulnerability index tool because we don't have the answers to the types of detailed questions that are being asked. All in all, we felt that this approach linking climate models and hydrologic models and then using both of those to provide data or input for a climate vulnerability index tool that this provides valuable information for resource managers. Both those who are water resource managers who need to better understand how their resource might be changing in the coming decades, and also for state, local, and federal agencies that are managing species and the karst habitat. There are two USGS reports that have resulted from this project. Both of these are available online.\nThere is a scientific investigations report first authored by John Stamm. This provides many more of the details than I've been able to share with you in the presentation today. There's a four-paged summary of the SIR available as a fact sheet. This would be really handy to be able to share with resource managers or even to be able to use in an academic setting. We also have some additional journal publications that have been the result of this work. In particular, if you're interested in learning how to use or create a site-specific hydrologic convolution model like Andy Long did, I would strongly suggest that you take a look at these two publications or contact Andy directly. That is the conclusion of my presentation.\nAt this time, I would be happy to answer any questions that you might have. John: Thank you, Barbara, for your presentation. First question comes from Than. I hope I pronounced that right. \"Is karst water temperature sensitive to air temperature changes? Do your hydrological models account for this spatial/temporal variation.\" Barbara: That's a really good question. The short answer is yes. In fact, all groundwater is sensitive to air temperature changes. Over fairly long spatial scales. Groundwater tends to reflect the ambient air temperature and ambient annual air temperature, but in karst we see much more rapid changes in water temperature. We see warmer temperatures in the summer, cooler temperatures in the winter, but we also see the effects of rapid recharge of that. If we get a big warm rain in the summer time, we'll see the water temperature of the spring increase.\nIf we get a cold rain in the winter, we'll see the water temperature decrease. This can happen over a matter of hours. In this particular model, we didn't model water temperature. We only modeled air temperature. However, Andy Long and I have been working on a convolution model that models water temperature from the springs using air temperature as an input. He's been very successful at matching that. That's a very promising direction that we can go. John: Next question is from Ryan Boyles. \"How difficult would it be to add additional GCMs or use existing downscaled projections? I suspect the results are very sensitive to the single GCM and scenario used.\" Barbara: Ryan, you're probably right that there is quite a bit of sensitivity to the scenario used and that we might see something different if we used a different GCM. It would be fairly labor-intensive to try out some different GCMs or different projections.\nI don't know if we can get John Stamm. He did call and he's our modeler. John, are you able to unmute yourself and address that question? John Stamm: Hey, can you hear me? Barbara: Yeah. John: That is a great question. One of the things, if we're able to move forward on this, is that the GCMs these days are getting very close to the resolution, the 36-kilometer resolution that we use. They're getting down around 50-kilometer resolution. At that point, you're able to resolve things like the Black Hills. They'll actually appear on there. You might see the Edwards Plateau. New GCMs that come out actually lend themselves much better to using this approach. Back when we were doing this work in 2012 to 2013, a lot of the models just didn't even resolve the Black Hills at all. It was difficult to use them. There really weren't that many downscale models at that time.\nJohn: The next question is, \"Do you have any suggestions or ideas about including evolutionary potential for any of the karst species?\" Barbara: I'm guessing that this question relates to whether that potential might be worked into the climate vulnerability index tool. Clearly, that index tool can be adapted for any user. That is something that we might want to consider. We do have some indication that, for example, the salamanders can evolve. The Eurycea sosorum is thought to be related to Eurycea nana which is in different aquifer system to the South. They are now genetically distinct. I think that they were originally thought to be the same species. That's something that could be considered. Either Mary or Amy, are you on the line? Could you address that question in any more details? Amy: This is Amy.\nCan you hear me? Barbara: I can. Amy: The CCVI does include…one of its things that it scored is genetic potential or basically how genetically diverse is the species. That is included in the vulnerability index. That information is often very difficult to find for a species. It actually ends up being an optional add-on in the CCVI. Barbara: You need to have that type of information on the species to be able to include it in the analysis. John: Next question is also from Ryan. That might be actually a statement. It does look like a statement. He's talking about different ways. With MACA and LOCA downscaled projection, you can get greater less than a 10-kilometer resolution across dozens of GCMs and that leads to emission scenarios. This might help characterize the uncertainty and help start thinking about adaptation planning. It would depend on how sensitive the hydro model is as to climate. The agreement between modeled and observed hydrology is impressive. John: This is John. There's a lot of products out there right now that we could use and apply this methodology.\nThis, to some extent, was a proof of concept paper. It's more than that, but it's our first time trying to do all these linkages. Barbara may be able to discuss a little bit more along those lines. Barbara: John, that's exactly right that we wanted to see how effectively we could link the models and pull in the hydrology and to what degree that might affect the vulnerability evaluation. Clearly, this can be expanded. I'd love to see this maybe done in more detailed…in these areas, but also apply to other areas where there are species of concern. John: We have a question from Eduardo. Have the modelers considered using NEXRAD precipitation to model the spring discharge response? Barbara: Andy, are you on the line? You want to handle this one? Andy: Sure. Can you hear me? Barbara: Yes. Andy: These models were site-specific. It's a time series model. It's not a distributed model.\nWe just used an appropriate weather station that was in the area of the spring discharge or water level that we were trying to predict and then calibrated the model that way. For the projection for the future, we used the WRF model output for that same location. We could've used NEXRAD also, but we felt the station data or the model calibration was better. John: Right now, I don't see any questions. I would like to just, once again, thank Barbara and everyone who participated. Barbara: Thank you very much. Transcription by CastingWords p..", "label": "Yes"}
{"text": "Plan Seed Starting\nIt seems so early, but some seeds, such as petunias and geraniums, need about four months after sowing to reach a respectable transplant size. Also, seeds of many perennials require chilling (cold stratification) prior to planting. If you expect to start seeds this spring, research the needs of the plants and plan your schedule accordingly. Don\\'t be late!\nStarting Indoor Cat Grass\nVisit the pet store and pick up a small, inexpensive packet of so-called cat grass seed. Plant it per label instructions in dampened potting mix, and set the container in a bright windowsill. Keep the soil slightly damp (not sopping wet) and enjoy the bright spring green! Share some with kitty, too.\nDelve into Catalogs\nMail-order catalogs make great winter reading material. Within them is a hoard of information. Discover what\\'s new this year, develop your horticulture skills using their plant descriptions and suggestions, and compare recommended growing conditions. With a little more effort you can even teach yourself the botanical names of your favorite plants.\nUse Evergreen Boughs\nTo recycle a cut Christmas tree, remove its branches and use them as a protective winter mulch in the garden. Place the branches flat so they shelter the crowns of perennials without weighing them down or smothering them. In spring, pull the branches aside so the plants can wake up naturally with the season.\nTry Something New!\nIf it\\'s been awhile since you tried something new and different in your garden, let this be the year you venture forth. There are many exciting new varieties of vegetables, as well as new introductions of annuals and perennials. And don\\'t neglect the new tree and shrub cultivars. There is sure to be something new to please your eye and palate this season!", "label": "Yes"}
{"text": "ARTICLE | doi:10.20944/preprints202204.0003.v2\nSubject: Life Sciences, Microbiology Keywords: Drug resistance; Efflux pump; TetR transcriptional regulator; Mycobacteria; MmpL\nOnline: 24 May 2022 (11:32:52 CEST)\nMycobacterium tuberculosis is a leading cause of human mortality worldwide and the emergence of drug-resistantstrains, demands the discovery of new classes of antimycobacterials that can be employed in the therapeutic pipeline. Previously, a secondary metabolite Chrysomycin A, isolated from Streptomyces sp. OA161 was shown to have potent bactericidal activity against drug-resistant clinical isolates of M. tuberculosis and different species of mycobacteria. The antibiotic inhibits the mycobacterial topoisomerase I and DNA gyrase leading to bacterial death, but the mechanisms that could cause resistance are currently unknown. To further understand the resistance mechanism, spontaneous resistance mutants were isolated and subjected to whole-genome sequencing. Mutation in a TetR family transcriptional regulator MSMEG_1380 was identified in the resistant isolates and was close to an operon encoding membrane protein MSMEG_1381 and MSMEG_1382. Sequence analysis and modeling studies indicated that they are components of the Mmp family of efflux pumps and over-expression of either the operon or individual genes conferred resistance to chrysomycin A, isoniazid, and ethambutol that are in TB therapy. Our study highlights the role of membrane transporter proteins in conferring multiple drug resistance and the utility of recombinant strains overexpressing membrane transporters in the drug screening pipeline.\nREVIEW | doi:10.20944/preprints202002.0458.v1\nSubject: Life Sciences, Biophysics Keywords: LacI; Lac repressor; TetR; TAL-Effector; transcription activator-like effector; Cas9d; dissociation rate constant\nOnline: 29 February 2020 (09:13:12 CET)\nThe recent developments in the delivery and design of transcription factors put their therapeutic applications within reach, exemplified by cell replacement, cancer differentiation and T-cell based cancer therapies. The success of such applications depends on the efficacy and precision in the action of transcription factors. The biophysical and genetic characterization of the paradigmatic prokaryotic repressors, LacI and TetR and the designer transcription factors, TALE and CRISPR-Cas9 revealed common rules, which can help the optimization of activators and repressors. Further studies will be required to analyze the linkage between dissociation constants and enzymatic activity, the role of phase separation and squelching in activation and repression, and the long-range interaction of transcription factors with epigenetic regulators in the context of the chromosomes. Understanding these mechanisms will help to tailor systematically optimized designer transcription factors to the needs of specific applications.", "label": "Yes"}
{"text": "Playing in the snow animals, wild or domestic, is definitely cause tenderness. But are there such animals apart from penguins and polar bears, for whom snow is a necessity, not just an excuse for fun? The magazine national geographic has compiled a sampling of eight animals, which found an unexpected practical application to snow and ice.\nThese primates is rightly called “snow monkeys”. “Japanese macaques are resistant to hot summer and cold winter, and many, especially the young, really enjoyed the snow,” — said the publication of the postgraduate Institute of Primate research Kiotskogo University Rafaela Takeshita.\nEven Japanese macaques can make snowballs and, although the structure of the clutches of these primates and you can not make shots, love to play with them. “I often watched as the young monkey was trying to steal from each other snowballs,” says Takeshita.\nIce worms and rotifers\nAs Elsa, the heroine of the cartoon “the Cold heart”, the ice worms feel most comfortable in the cold. These black annelids length just a few inches belong to the few animals living inside glaciers. The same lovers of low temperatures and are microscopic creatures bdelloidea rotifers, two of which were opened in the glaciers of Iceland specialists Rutgers University. The average temperature in these glaciers is around zero — that’s enough to ice worms and rotifers will not freeze.\nRotifers are able to survive a week-long stay at a temperature of -60 degrees and successfully recover after this. These primitive animals, among which there are only females, they reproduce asexually, and to maintain genetic diversity use genes of other animals — their prey.\nMice and shrews\n“Snow is an incredibly good insulation material, under which animals can dig holes in the warm humid space, the so-called subnival zones zone” — gerot Greg breed, ecologist University of Alaska in Fairbanks. As you know, mice and shrews are digging their own ventilated nests and tunnels: winter snow cover makes these underground homes are more protected from predators and creates a constant positive temperature. As explained by brides, snow actually increases the chances of these animals to survive.\nFor grey wolves high snow cover in winter is a guarantee of fullness. For many animals — prey wolves — abundance of snow slows down and complicates movement, and thus makes it more vulnerable. Besides the snow and cold allow you to preserve and feed less. For the Arctic wolves, however, the abundance of snow (and, as a consequence, complicated movement) can play a cruel joke, as these predators are themselves prey of polar bears.\nButterflies also found the practical application of the insulating effect of snow. Some species of these insects hibernate and spend the winter directly below the snow cover in a fairly warm and humid space, the saving from dehydration and freezing.", "label": "Yes"}
{"text": "The Victorian health department is advising people to monitor for meningococcal symptoms after a case connected to schoolies celebrations in Queensland.\n- An 18-year-old who attended schoolies in Queensland has been diagnosed with meningococcal disease\n- The health department is advising people who attended venues in Maroochydore from November 26 to December 2 to watch for symptoms\n- The state's deputy chief health officer says early treatment for meningococcal is life saving\nAn 18-year-old has been diagnosed with the disease after celebrating in Maroochydore, on Queensland's Sunshine Coast.\nThe department is advising people who attended social venues in Maroochydore between November 26 and December 2 to be alert to meningococcal symptoms and to act immediately if they appear.\nSymptoms include sudden onset of fever, headache, neck stiffness, joint pain, a rash of red-purple spots or bruises, sensitivity to bright lights, nausea and vomiting.\nVictorian deputy Chief Health Officer Deborah Friedman said people should immediately seek medical attention if they suspected symptoms of the disease.\n\"Early treatment for meningococcal is life-saving,\" she said.\nThe department said children under the age of five and people between the ages of 15 and 25 were at greatest risk of contracting the disease, though it could affect all age groups.\nChildren might experience non-specific symptoms like irritability, difficulty waking, refusal to eat and high-pitched crying.\n\"The close contact between young people at events like Schoolies might have placed them at increased risk of contracting this infection,\" Dr Friedman said.\nThe department said meningococcal infections were uncommon thanks to vaccination.\nFourteen cases of the disease have been reported in Victoria so far this year.\nTwo people from New South Wales died from meningococcal after attending music festivals earlier in the year.\n\"Vaccination remains the best way to protect yourself, your loved ones and the community from the harmful effects of meningococcal disease,' Dr Friedman said.\nThe disease is caused by strains of bacteria found in the upper respiratory tract and can spread from person to person through close or prolonged contact.", "label": "Yes"}
{"text": "After two and a half years into the COVID-19 pandemic and after many digital attempts to keep scientific communication and discussion going, it was finally possible to meet again in person for the International Conference of our Society (Botanik-Tagung) at the University of Bonn. Originally, the meeting was scheduled for 2021 already, but got rescheduled by one year to ensure an in person meeting. This was highly appreciated by the scientific community and resulted in more than 600 attendees despite the fact that the pandemic is not over yet. It was, however, very positive to see almost everyone at the meeting wearing face masks, and it cannot be overstated that not a single case of confirmed infections was reported during or shortly after the meeting. With only three dropouts caused by infections shortly beforehand, this can be considered a huge success.\nCompared to former meetings of our society, the first major change that has been implemented at the Bonn meeting is the German title. This is now Botanik-Tagung to specifically mention and reflect on the subject rather than giving the false impression in the German language of an exclusive male scientists’ meeting.\nPlant Sciences for our Sustainable Future\nConference chair, Professor Dr. Andreas Meyer, and his local team organized the meeting from August 28 to September 1, 2022 at the main building of the University of Bonn under the slogan Plant Sciences for a Sustainable Future. This motto expresses the increasing awareness that we have to ensure sustainability of our economic and ecological actions and that plant sciences takes a key role in this effort. It also links directly to one of the central interdisciplinary research activities at the University of Bonn and was picked up by the rector of the University of Bonn, Professor Dr. Dr. hc. Michael Hoch, in his welcome address. Professor Hoch pointed out that there may in fact be multiple views and interpretations on sustainability such that there is a need to address this in plural form as done by the University of Bonn in the Transdisciplinary Research Area Sustainable Futures. There is, however, full agreement that plants are key to sustainability in human nutrition and global ecology.\nPlant Research to Combat Climate Crisis and Feed the World\nIn his welcome address the president of the DBG, Professor Dr. Andreas Weber, pointed at the need for more plant research to combat the global carbon problem, which without any action will last for centuries even if net zero carbon emissions can be achieved within a few decades from now. The impact of plant sciences on the society and the need for further research to bolster up global food supply both in terms of total amounts and quality, were emphasized in a brilliant public talk by Professor Dr. Matin Qaim on Sustainable Global Nutrition and the Role of Plant Breeding. Professor Qaim emphasized that the use of genetically improved organisms should not be taken as synonymous with industrialized agriculture but rather interpreted as having the potential for enabling a more sustainable agriculture. Generally, it is important to focus on plant characters rather than the employed breeding technologies and be open to new technologies if no scientific arguments stand against their implementation.\nPlant Science is Coming Home\nIn his welcome address, Professor Andreas Meyer also emphasized that Bonn in the 19th century has been the work place of many excellent plant scientists at both the University and the predecessor of today’s Agricultural Faculty, then the Agricultural Academy at Poppelsdorf. The list of prominent names includes scientists like Christian Nees von Esenbeck, Wilhelm Pfeffer, Hermann Schacht, Friedrich Körnicke, Robert Caspary, Andreas Schimper, Julius von Sachs, and last but not least of course Eduard Strasburger. Together with the groundbreaking work done by all these scientists, the textbook written by Strasburger, Schimper, Noll and Schenck ̶ which today is released in its 38th edition ̶ and simply known as “the Strasburger” highlights Bonn to be a hotspot for plant sciences in the 19th century and that the claim Plant Science is Coming Home in form of this meeting is thus fully justified. To honor and memorize these eminent names, the eight plenary lectures were named after these scientists. All historic figures were briefly introduced by the respective session chairs before the invited plenary speakers took over. To further commemorate the history of Bonn Plant Sciences and to make conference attendees acquainted with the historic figures, the conference organizers invented a little picture puzzle in which attendees were asked to identify ten leading scientists of the 19th century by name based on their portraits.\nFlat leaves and Chloroplasts\nIn the Strasburger lecture, Marja Timmermans (Tübingen), provided exciting insight into mRNA-based signaling mechanisms that underlie the formation of a flat leaf. Mathematical models describing the process show that the respective gene regulatory network follows the organizing principles of a Turing system. Due to a COVID-19 infection Matthew Johnson (Sheffield, UK) unfortunately could not make it to Bonn, but fortunately he was fit enough to deliver the Schimper lecture online. With Schimper having first recognized chloroplasts as descendants of free living cyanobacteria-like bacteria, Matthew Johnson now provided biochemical and biophysical detail on how the proton motive force in chloroplasts is regulated.\nNovel Natural Products and Nitrate Transporters\nAnne Osbourne (Norwich, UK) in her Pfeffer lecture highlighted the potential of biological diversity for identification of novel natural products and described translational synthetic biology approaches for preparative production of such compounds. Yi-Fang Tsay (Taipeh, Taiwan) gave the von Sachs lecture and provided in depth insight into nitrate transport, sensing and the optimization of nitrate utilization efficiency. With her characterization of several nitrate transporters she convincingly showed that nitrate in addition to the xylem can also be transported in the phloem.\nBiological and Morphological Diversity\nBiological diversity was also addressed by Marcus Koch (Heidelberg) in the Nees von Esenbeck lecture. In these studies, however, the morphological diversity was investigated through comparative genomics. Morphological diversity is considered the major product of macroevolution and to quantitatively describe the amount of morphological variation, the term morphological disparity was introduced. With his work Marcus Koch showed that Brassicaceae may pave the way for developing concepts of phylogenetic genome-wide association studies to analyze the evolution and the basis of morphological form and function.\nPlants get frequently infected by pathogenic organisms as described already in the 19th century for nematodes by Schacht. In a similar way, plants also get infected by fungi and this goes along with a complex interaction between the fungus, the host plants and also beneficial plant-associated microbes as Bart Thomma (Cologne) highlighted in his Schacht lecture. Detailed molecular and metabolic analysis shows that pathogenic fungi exploit effector proteins with selective antimicrobial properties to promote host colonization through the manipulation of beneficial host microbiota.\nStress Reactions in Developing Cereal Crops\nMaria von Korff Schmising (Düsseldorf) is well-known for her work on cereal crops and especially barley for which she was recently elected to the national academy Leopoldina. At this meeting she presented her work on inflorescence development and floral abortion under stress in barley in the Körnicke lecture. Using global transcriptomic profiling of developing shoot apical meristems under abiotic stress in genotypes with different stress responses, genes and gene networks controlling spike development, floret fertility and grain set under stress were identified. The work highlights how natural genetic variation for developmental plasticity in stress responses in germplasm collections can be exploited for new functional insights into how plants work.\nCell Wall Formation\n‘Caspary’s strip as a model for localized cell wall formation’ was the title of the Caspary lecture delivered by Niko Geldner (Lausanne, Switzerland). In his lecture, he took the audience on a journey from the early days of the first identification of a new root cell type characterized by ring-shaped cell wall incrustations, which nowadays of course is known as the Casparian strip, to the molecular principles underlying its formation. Major new insights result from entirely deleting highly redundant CASP proteins and identification of potential interactors of CASP. Nico Geldner managed to excite the audience literally to the last minute of this meeting.\nSymposia and more than 300 Posters Covered the full Breadth of Plant Sciences\nBeyond the eight plenary lectures, the full breadth of plant science was covered in 21 symposia. With the exception of an open session entitled Topics on the Rise all other sessions were set with one invited keynote speaker. In most cases, these keynotes were delivered by international guests for whom funding was provided by the German Research Foundation (DFG). Additional funding was kindly provided by the local excellence cluster PhenoRob and the German Society of Plant Nutrition who both funded one speaker for symposia covering the respective scientific areas.\nTo further ensure full coverage of plant sciences, all six sections of the DBG organized at least one symposium each focusing on their respective subject areas. In full awareness of the fact that even with 20 distinct symposia it is not possible to cover all parts of plant science, especially with highly dynamic new developments at the forefront of research, the symposium Topics on the Rise offered an opportunity for all those participants, who could not be assigned to any other topic. In total, the fully set program gave about 130 scientists a chance to present their work in oral form. For these presentations, a clear preference was given to early career scientists including PhD students.\nYet, many additional requests for oral presentations had to be declined and allocated to the two poster presentation sessions. At the same time, it is noted that this further improved the quality standards of the poster sessions with altogether more than 300 posters on display. The fire protection rules of the University of Bonn prevented that all posters could be on display for the complete conference, rather they were displayed for only one day within two general poster session. A complimentary digital poster session on several local work stations, however, ensured that all posters could be looked at any time during the whole meeting.\nPoster Prizes and Honors\nThe more than 300 posters made it very challenging to select 10 posters for awards. Here a two-stage selection process with an initial public vote and a second selection round by a committee of advanced postdocs and professors was chosen to ensure a selection process that is quality-based and yet fair in terms of subjects selected for the awards. It is noted that this procedure led to a result in which the respective awardees represent the full breadth of plant sciences.\nScience Prizes for Early Career Scientists\nThree young scientists, Dr. Rabea Meyberg, Dr. Meike Hüdig and Dr. Kai Bartusch were honored for their groundbreaking original work with science awards handed out by the Pfeffer, Strasburger and Wiehe trusts, respectively. As usual, the DBG also held its general assembly during the conference. During this assembly the DBG announced Professor Dr. Widmar Tanner (Regensburg), Professor Dr. Birgit Piechulla (Rostock) and PD Dr. Klaus Appenroth (Jena) as new honorary members of the society for their individual long-term contributions to science and the DBG. In addition, the two former presidents of the DBG, Professor Dr. Ulf-Ingo Flügge (Cologne) and Professor Dr. Karl-Josef Dietz (Bielefeld), were honored with DBG’s Simon-Schwendener Medal for their long-term support of the interests of the society.\nFarewell and Outlook\nBefore the farewell session Professor Andreas Meyer presented the solutions to name the portrait images of the leading plant scientists in the 19th Century who did their research at the University of Bonn. Altogether 53 attendees participated in the quiz and some of these allegedly spend most of Monday night to find the correct answers. In the end, 13 submitted ballots were completely correct and thus the winners of a bottle of Ahr valley wine and two conference T-shirts had to be drawn.\nThe first in person meeting into the COVID-19 pandemic can be legitimately considered a huge success. This would not have been possible without support from colleagues in Bonn and Jülich, support from University staff and the many helping hands from student assistants and the nice work of the photographers. Furthermore, the meeting was supported by many colleagues from other Universities, who helped organizing symposia and inviting high profile international guest. Last not least, I am also grateful to the support staff from our conference management partners at Conventus, Jena. Without their support and input it would not have been possible to make this conference a success.\nGoing back to the original two-year rhythm for our meeting, the next conference has been announced to be organized by Professor Edgar Peiter and his team of co-organizers at the University of Halle-Wittenberg in 2024. By chance, in historic terms, Halle appears to be the logic recipient of the baton as one of the original authors of the Strasburger text book, Dr. Fritz Noll, soon after publishing the text book became professor at the University of Halle. On behalf of the organizers in Bonn and our German Society for Plant Sciences I thank all attendees for their exciting contributions and look forward to meeting you again in Halle.\nBonn, October 2022\nProf. Andreas Meyer, Conference Chair, Professur für Chemical Signalling", "label": "Yes"}
{"text": "Your body needs the right vitamins to do its job of keeping your skin fresh and healthy.\nEnsuring that your skin gets enough vitamins can keep your skin looking youthful and healthy. This could mean your skin is dark spots free, and there’s no redness, wrinkles, excessive dryness, and rough patches on your skin.\nWe’ve all heard “you need your vitamins” at least once in our life. But do we ever think about the reason behind it? Well, vitamins majorly shape our health, including the skin.\nWhen you meet a medical professional and ask them what you need to do to keep your skin healthy, they’ll first say to limit your exposure to the sun’s harmful ultraviolet (UV) rays and always put on a protective sunscreen when you’re exposed to sunlight.\nCome to think of it, the sun isn’t all bad. Daily sunlight for about 10 to 15 minutes helps give the skin vitamin D. One of the best vitamins for the skin is vitamin D, along with others such as vitamins E, C, and K.\nThere are different types of vitamins, with each having its benefits. While some help to keep your nerves healthy, some fight against infections and others regenerate your skin.\nThis piece reveals the best five vitamins for your skin, how it benefits your skin, and the food that contains each vitamin.\nA debate has been going on as to whether using a sunscreen every day or not can cause Vitamin D deficiency. But the thing is, your body produces Vitamin D when sun rays penetrate through your skin.\nNotwithstanding, deficiency is not as severe as the harmful ultraviolet (UV) rays can cause to your skin. Ten minutes of exposure to the early morning sun is enough to get your daily dose of Vitamin D. Steer clear from the sun during its peak hours (10 am to 2 pm).\nHow does Vitamin D benefit your skin?\nWhen Vitamin D is absorbed through your skin, cholesterol will convert to Vitamin D. This is then taken up by the liver and kidneys and transported throughout the body to create healthy cells, including skin cells. Vitamin D plays a crucial role in skin tone and may also help treat psoriasis.\nFoods that contain Vitamin D\nVitamin D can also be gotten from certain foods and supplements. Some foods are eggs, fatty fish, dairy products, soy products, and cereals.\nVitamin E is an antioxidant that contributes to several functions to keep up with healthy skin.\nHow does Vitamin E benefit your skin?\nUsing a skin care product containing Vitamin E benefits your skin by reducing the risk of sun damage via UV rays absorption from the sun. It will give you glowing skin; conditioned and moisturised, and prevent it from feeling irritated.\nThe body also produces vitamin E naturally through an oil known as sebum. Sebum is vital to maintaining glowing skin. For better efficacy, it is recommended that you consume foods containing vitamin E.\nFoods that contain Vitamin E\nThough vitamin E is obtainable in many skin care products, the issue is that any effects could be insignificant upon sun exposure. Thus, getting sufficient vitamin E in your diet is more desirable. Some foods you can get vitamin E from are; vegetable oils, nuts and seeds, green vegetables, and certain cereals and juices.\nVitamin C can be found in the epidermis (topmost layer of skin) and the dermis (inner layer of skin). It has antioxidant (cancer-fighting) properties. In addition, its role in collagen production helps to keep your skin healthy. This is why vitamin C is a significant ingredient in many anti-ageing skin care products.\nHow does Vitamin C benefit your skin?\nVitamin C commonly treats various skin problems, including acne, fine lines, hyperpigmentation, and dark spots.\nIn addition, it enhances collagen (a protein fibre that gives the skin strength and keeps it firm) production in the skin. As you age, the production of collagen cuts down naturally, and the years of exposure to the sun can also break down collagen in the skin.\nBut the topical application of vitamin C can increase collagen production, thereby reducing the appearance of fine lines and wrinkles. It also lightens pigmentation spots and reduces tan by altering the activity of the enzyme tyrosinase, which involves the production of melanin (skin pigment).\nThe consumption of vitamin C orally can help enhance your sunscreen’s efficacy by speeding up the body’s healing process as a result of reducing cell damage.\nFoods that contain Vitamin C\nVitamin C deficiency is very rare due to the generality of dietary supplements, over-the-counter products, and foods we eat. However, if you find that you’re not getting enough, you can take foods like; broccoli, cauliflower, capsicum, and sprouts. Citrus fruits like oranges, lemon, and other vitamin C-rich fruits like papaya and strawberries also have substantial amounts of nutrients.\nVitamin K plays the utmost role in treating a host of skin issues and conditions. The deficiency of Vitamin K has been known to be rare since it can be found in almost all varieties of food.\nHow does Vitamin K benefit your skin?\nVitamin K’s major benefits are fading of scars, stretch marks, spider veins, and dark spots. It also aids the body’s healing process, effectively treating bruises and wounds.\nFoods that contain Vitamin K\nYou can increase your vitamin K intake by eating; green leafy vegetables (such as kale, spinach, romaine, and lettuce), fish, sprouts, eggs, broccoli, cauliflower, and cabbage.\nVitamin A is widely used in a number of skincare products due to its antioxidant properties. Your sunscreen, serums, and moisturisers may contain this magic ingredient.\nHow does Vitamin A benefit your skin?\nRetinoids are a form of Vitamin A that is popularly used in oral and anti-acne medicines because they have anti-inflammatory properties that help to improve acne symptoms.\nFoods that contain Vitamin A\nGood sources of vitamin A include; cod liver oil, cereals, fortified skimmed milk, eggs, green vegetables, and orange fruits.\nIn conclusion, Vitamin supplements are easy to get these days; therefore speak with a doctor to start a regimen for your health. While vitamins are necessary for glowing skin, you might already be getting enough through your daily diet. But a blood test can help determine if you have any vitamin deficiencies.\nYou should only take vitamins under the direction of a medical specialist to prevent overdose.", "label": "Yes"}
{"text": "Here we are debunking yet another inaccurate Instagram post. Recent research suggests that the endogenous cannabinoids (“endocannabinoids”) and the cannabinoid (CB) receptors have a major influence during pre- and post-natal development. But you can find several posts throughout social media making inaccurate claims regarding the type of cannabinoids that have been found in breast milk. The following post found on Instagram claims the following...\n\"Study confirms Cannabinoids Occur Naturally in Human Breast Milk ...According to the findings of several major scientific studies, human breast milk naturally contains of the same cannabinoids found in the cannabis plant, which are vital for proper human development.\"\nWhile most informed scientists cringe at the inaccuracy of this post, with a simple Google search you can find several articles inaccurately claiming that human breast milk naturally contains the SAME cannabinoids found in the cannabis plant.\nIn order to debunk this widespread inaccuracy, it is important to explain the difference between phytocannabinoids and endocannabinoids.\n\"Phyto\" is a prefix meaning \"of a plant\" and is used in the formation of compound words. Thus, the term phytocannabinoid is used to describe cannabinoids derived from a plant.\n\"Endo\" is a prefix from the Greek word endon (ἔνδον) meaning \"within, inner, absorbing, or containing\" and is often used in the formation of medical compound words referencing nomenclature defining compounds with origins from within a biological body. Thus, the term endocannabinoid is used to describe cannabinoids synthesized from within a biological body.\nBecause phytocannabinoids are NOT the same as endocannabinoids, we decided to recreate the Instagram post to reflect an accurate statement derived from current scientific research.\n\"According to scientific research, endocannabinoids are present in breast milk, 2-AG levels being much higher than those of anandamide, suggesting that the endocannabinoid system plays a major role in human development.\"\nFor those unfamiliar with endocannabinoids, two of the most studied endocannabinoids are 2-AG and anandamide (anandamide being nicknamed \"the bliss molecule\"). Subsequently, two of the most studied phytocannabinoids are CBD and delta-9 THC.\nWhile anandamide structurally resembles delta-9 THC, they are two completely different molecules, having different effects on the body. Additionally, CBD does not resemble any endocannabinoid found in the human body. In fact, it doesn't even bind directly to the cannabinoid (CB) receptors. Instead, CBD changes the shape of the receptors, increasing the binding affinity of endogenous molecules found inside our bodies.\nAnandamide acts as a chemical messenger between the embryo and uterus during implantation in the uterine wall. Therefore, anandamide is one of the first communications that occurs between mother and child. Due to the structural similarity between delta-9 THC and anandamide, scientists have raised the possibility that delta-9 THC may interfere with signaling between the uterus and the embryo. Experiments involving mouse embryos exposed to THC-like compounds have shown them to have a significantly lower survival rate than normal, as well as exhibit a number of abnormalities. Thus, consumption of cannabis during pregnancy is strongly advised against.\nIn women accordingly, an association has been reported between fatty acid amide hydrolase (the enzyme that breaks down anandamide) in human lymphocytes and the occurrence of miscarriages. It is important to note that a reported association is not sufficient evidence to make any scientific conclusions. Additionally activation of CB1 receptors appears to be critical for milk sucking by newborn mice, apparently activating oral–motor musculature. This animal study observation has not yet been conducted in humans to see if the correlation translates from animals to humans.\nWhile the medical implications of these novel observations suggest a promising future for cannabinoids in medicine for a variety of conditions, it is important that misinformation does not become misperceived as common knowledge.\nHave a Cannabis post you'd like for us to debunk? Send it to us at email@example.com!", "label": "Yes"}
{"text": "An important mechanism by which IFN-γ primes macrophages for enhanced innate immune responses is abrogation of feedback inhibitory pathways. Accordingly, IFN-γ abrogates endotoxin tolerance, a major negative feedback loop that silences expression of inflammatory cytokine genes in macrophages previously exposed to endotoxin/Toll-like receptor (TLR) ligands. Mechanisms by which IFN-γ inhibits endotoxin tolerance have not been elucidated. Here, we show that pretreatment with IFN-γ prevented tolerization of primary human monocytes and restored TLR4-mediated induction of various proinflammatory cytokines, including IL-6 and TNFα. Surprisingly, IFN-γ did not alter proximal TLR4 signaling defects in tolerized monocytes. Instead, IFN-γ blocked tolerance-associated down-regulation of IL6 and TNF transcription, RNA polymerase II recruitment, and NF-κB and CCAAT/enhancer-binding protein β transcription factor binding to the IL6 and TNF promoters in tolerized monocytes. The mechanism by which IFN-γ restored IL6 expression was by facilitating TLR4-induced recruitment of chromatin remodeling machinery to the IL6 promoter and promoting IL6 locus accessibility in tolerized monocytes. Our results suggest that IFN-γ overcomes endotoxin tolerance by facilitating TLR-induced chromatin remodeling to allow expression of proinflammatory genes. These results identify a mechanism by which IFN-γ promotes activation of macrophages and highlight the importance of chromatin remodeling and transcriptional control in the regulation of inflammatory cytokine production in tolerant and activated macrophages.", "label": "Yes"}
{"text": "Supplementary MaterialsS1 Text message: Endoplasmic reticulum construction\nSupplementary MaterialsS1 Text message: Endoplasmic reticulum construction. 20 simulation replicates had been performed.(PNG) pcbi.1007717.s005.png (271K) GUID:?A1562B6F-0FC2-456D-B293-A53F3FF0D7DC S1 Desk: Parameters found in the mobile automata program order PTC124 to generate practical ER. (TEX) pcbi.1007717.s006.tformer mate (484 bytes) GUID:?A3D3311F-28FE-48F7-9E66-66485CA32A5C S2 Desk: Diffusion coefficients for species involved with splicing particles formation. Abbreviations are: nucleus (N), NPC (P), Cajal physiques (J), nuclear speckles (S) and cytoplasm (C).(TEX) pcbi.1007717.s007.tformer mate (1.3K) GUID:?8B07CA27-71FD-41EA-A4B5-74A11F4E5DC6 S3 Desk: Diffusion coefficients of spliceosomal contaminants. Abbreviations are: nucleus (N) and nuclear speckles (S).(TEX) pcbi.1007717.s008.tformer mate (584 bytes) GUID:?54858274-F880-481F-B609-98082C1C0524 S4 Desk: The outcomes from the simulations models having a network-like morphology from the mitochondria when compared with the fragmented-mitochondria which were reported in the primary text message. (TEX) pcbi.1007717.s009.tformer mate (670 bytes) order PTC124 GUID:?2A1E09B6-B38E-4D84-96EF-27859908C1AC S5 Desk: The p-values of data from different simulation models. (TEX) pcbi.1007717.s010.tformer mate (414 bytes) GUID:?ECE4C6AF-CE9B-426A-9BC1-F6BFF142B620 Connection: Submitted filename: spatially-resolved style of a HeLa cell from a library of experimental data such as for example cryo-electron tomography , mass spectrometry , fluorescence order PTC124 live-cell and microscopy imaging [11, 14C16], and -omics data [17, 18]. We develop kinetic versions to spell it out the response network of RNA splicing relative to the known natural occasions. The kinetic versions were integrated into our spatially-resolved eukaryotic cell model, filled with organelles, biomacromolecules and compartments. We FLNA after that perform simulations using stochastic reaction-diffusion get better at equations (RDME) with this previously-developed order PTC124 cell simulation software program, Lattice Microbes (LM) [19, 20] for to quarter-hour of natural period up. Interfacing our model using the LM [19, 20], distinctively enables us to review the kinetics order PTC124 of mobile activity on the relevant biological time scale up to hours. LM takes advantage of multiple-GPU processors, and therefore benchmarks much faster than similar softwares (e.g., Virtual Cell), as we have shown previously [21, 22]. Therefore, simulating 15 minutes of biological time on multiple-GPU processors, for nuclear processes and entire human cell, takes 20 minutes and 15 hours of walltime, respectively. The utilized GPU architecture which is also available to other research groups (through supercomputers and GPU cloud computing) and the details of the working principles of LM are explained in the Methods section. The assumptions of constructing the spatial model of the human cell and the reaction schemes include: 1. Our study aims to investigate the RNA splicing process and the main organelles that are directly associated with this process including: the nucleus, nuclear speckles, Cajal bodies and parts of the cytoplasm (ER, mitochondria, Golgi apparatus). Therefore, our spatial model of the human cell mainly includes these organelles/ compartments. 2. Because the average protein half-life in human being cells can be 9 hours , a quasi-steady cell condition is assumed on the quarter-hour of natural period that was simulated. Consequently, processes such as for example transcription and translation from the genes encoding the protein concerning in the RNA splicing procedure weren’t explicitly modeled. 3. We centered on building the groundwork for an versatile platform for building and simulation of spatial types of human being cells. Therefore, the mobile organelles/compartments which have not really yet been contained in the current edition from the model could be easily added through the offered Python code. We believe that any needed response or spatial parts will become added from the analysts of our community. Our simulations, offering quarter-hour of natural period of the 1st spatially-resolved human being cell model, explore how mobile organization impacts the effectiveness of spliceosomal particle development and pre-mRNA splicing. We discover that obvious adjustments in the amount of nuclear pore complexes influence the amount of constructed splicing contaminants, an impact that remains constant for different nuclear sizes; and quantitatively, the forming of correctly-assembled splicing contaminants in multiple compartments can be better. We also display that a good slight upsurge in the comparative localization of splicing contaminants in nuclear speckles concurrently enhances mRNA creation and reduces sound in the generated mRNA. We’re able to rationalize how the properties of nuclear speckles progressed while at the mercy of physical constraints, such as for example their number and size. Finally, we forecast that the business of energetic genes around nuclear speckles impacts mRNA production. Outcomes Spatially-resolved style of a HeLa.", "label": "Yes"}
{"text": "6 Things You Can Do to Boost Your Immune System Right Now\nIt’s the start of autumn, so either you’ve already caught the common cold or you're probably going to. (And are desperately avoiding the co-worker who came in sick in an attempt to avoid it.) Instead of dancing around the sniffles, why not take action and use these all natural immune system boosters to ward off nasty germs?\nWhile there is no sure-fire way to prevent the common cold from wreaking havoc on our systems, they have yet to create a magical pill to do away with nasal drip and coughing. In the meantime, you can boost your immunity with these six simple and all natural steps. From properly washing your hands and preventing the spread of bacteria to getting your daily sweat on and improving overall health, we’ve rounded up the easiest and most effective ways to prevent falling ill. For more tips on how to avoid the common cold and boost your immune system this season, keep on reading.\nWell + Good\nAccording to the Cleveland Clinic, a healthy immune system functions best when it’s been fed a balanced mix of vitamins and minerals over time. So instead of ingesting a quick burst of vitamin C when you feel a cold coming on, plan ahead and include immune-boosting foods packed with plenty of vitamins A, C, E, folic acid, and iron in your daily diet to help your immune system perform at optimal levels.\nCulturelle Probiotic All Natural Dairy & Gluten Free Vegetable Capsules ($21)\nAccording to a study in the European Journal of Nutrition, certain probiotics can boost the body's immune function and reduce the risk of infection from the common cold. So what type of probiotic should you be taking? According to Dr. Frank Lipman, you should look for a probiotic with 10-20 billion organisms, and take one every day.\nThe Chriselle Factor\nWhen it comes to staying healthy, we have just one word for you: breathe. According to a study conducted by Sheldon Cohen, psychological stress effects the body's ability to regulate inflammation and can thus lead to disease. To prevent a case of the sniffles or the stuck-in-bed-for-five-days flu, try reducing your stress levels. While that is easier said than done, we have some suggestions that might make it easier for you.\nWe all know that washing our hands keeps germs at bay—but make sure to rinse with regular soap and water, says Dr. Lipman. The recent popularity of antibacterial soap has created harsher products, which are loaded with toxins that can actually increase the risk of creating resistant bacteria. These soaps also tend to over-dry and crack the skin, making the transmission of viruses that much easier. So, stock-up on non-drying soaps like the one above, and keep them on hand throughout the season.\nYoga Design Lab Combo Geo Mat ($108)\nRegular exercise helps expel toxins from your body. Plus, Dr. David Williams explains that the heat you generate while exercising can kill pathogens, while at the same time energising your cells and metabolism for improved health. So whether it’s your weekly sweat session at yoga or a quick at-home workout, make exercise a priority!\nWe all know that sleep is essential to, well, anything, but it really applies to a healthy immune system as well. According to the experts at the Mayo Clinic, people who don't get enough sleep are more likely to get sick after being exposed to a virus like a nasty cold. Lack of sleep can also affect how fast you recover if you do get sick, so it's absolutely essential to get enough rest, especially when you are experiencing a busier social life than normal. Do you have a hard time falling asleep? Try this quick trick for falling asleep in less than one minute.\nLooking for more immunity-boosting tips? Check out these 5 immune-boosting supplements.\nThis story was originally published December 29, 2015.", "label": "Yes"}
{"text": "|Tested species reactivity||Human, Mouse|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||KLH conjugated synthetic peptide between 187-214 amino acids from the central region of human SUV4-20H2|\n|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|\n|Contains||0.09% sodium azide|\n|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|\n|Tested Applications||Dilution *|\n|Flow Cytometry (Flow)||1:10-1:50|\n|Western Blot (WB)||1:1000|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nThis antibody is predicted to react with rat based on sequence homology.\nSUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "label": "Yes"}
{"text": "A DEXA scan is a bone density scan. DEXA stands for dual energy X-ray absorptiometry. It is used to see if there are any signs of osteopenia, osteoporosis or other bone problems. An X-ray technician performs the procedure. A DEXA scan is also useful for determining the severity of an already diagnosed bone problem or for seeing if treatment for a bone problem is working.\nPeople who are at risk of osteoporosis undergo routine DEXA scans. If a doctor suspects that a patient may have osteoporosis, he or she may order a DEXA scan. People who have osteoporosis may be scanned regularly to see if the disease has worsened. People who are currently being treated for osteoporosis may also be scanned to determine if their treatment is working or if the disease is progressing.\nPatients will not be asked to do anything to prepare for the exam. Doctors may talk to them about the exam to prepare them mentally and help them understand the process and the results. Doctors may also ask their patients to avoid certain things in the weeks leading up to a DEXA scan and on the day of the test. Those things may include,\n•No prior radionuclide studies for two weeks\n•No barium contrast studies for two weeks\n•No metal in clothing\nThe scan only takes about 15 minutes. The patient will be asked to lie down on a table. An X-ray scans the hips and the spine. The doctor will print out photos of the X-rays and will look at them to determine if there are any signs of osteoporosis or other bone diseases, or if a diagnosed disease has improved or worsened. Doctors do this by comparing the amount of calcium that appears in the X-rays of the patient’s bones with the amount of calcium found in the bones of a healthy person.\nDEXA scans are non-invasive, so there is no recovery time. Doctors will normally inform the patient about what to do next and how to deal with their diagnosis. Patients who have a hard time lying down for long periods may feel stiff after the procedure, but that should wear off quickly once the patient moves around.\nDoctors will receive results from the scan within a few days; some may even get them the same day. The results are reported as a T-score. A T score of -1 to -2.5 is considered osteopenia, and T-score of less than -2.5 is considered osteoporosis. Doctors use this scale to determine the severity of the bone disease and to come up with the right treatment. Most doctors will recommend that their patients begin treatment as soon as possible to stop the disease from progressing even more. They may continue to order regular DEXA scans to check on the patient’s progress and to decide if there are any other issues that may need treatment.", "label": "Yes"}
{"text": "Synthesizing spider thread—which is stronger than nylon and even some metals—has been a vexing problem. Until now.\nA Japanese startup claims it has cracked the knotty problem of commercializing the production of spider thread, which, gram for gram, is stronger than nylon and even many metals. As one of nature’s super-substances — tougher than Kevlar yet significantly more elastic — scientists have been trying to recreate it in significant quantities in labs but failed for over a decade.\nBy using synthetic biology techniques and a new spinning technology, Spiber Inc. says it is now able to produce many hundreds of grams of synthetic spider silk protein where past efforts have produced less than a few grams over a day. One gram of the special protein produces about 9,000 meters (29,527 feet) of silk.\nThe breakthrough, says the inventor and Spiber’s president, Kazuhide Sekiyama, is that unlike other attempts to synthesize spider thread the Japanese researchers did not try to copy the spider’s little-understood spinning action. Using duct-like spinnerets, spiders rearrange a simple protein to turn it into silk. “We make fibers using a totally artificial process,” he told Fortune.\nIn the world of biomimicry, or biomimetics, where cutting edge analytical techniques are helping put some of nature’s better ideas to work in industry, spider silk is something of a holy grail.\nEngineers have been adept up to now at synthesizing a range of extremely useful materials. But they could do better. Kevlar, for example, is a remarkably strong fiber used in aeronautics and bullet-proof vests. Made by heating petroleum products to 1,400 degrees Fahrenheit, then applying substantial pressure, the fiber is teased out to make the final fabric.\nTo a spider, the process would seem a tad hyperactive. Without using anything like that kind of heat, spiders produce a material that’s many times stronger than Kevlar, not to mention biodegradable. Clearly, a synthetic equivalent of spider thread would be of enormous benefit. Biomimetics and synthetic biology helps scientists create spider thread not by copying it exactly but by incorporating some of nature’s design aspects. It also shows the potential of such synthetic biology — breaking down nature into spare parts and then rebuilding them back up as desired.\nThis can take inventors down some strange avenues. Ten years ago, U.S. researchers came up with the idea of creating “Spider goats” that had their milk genes altered with spider DNA. The resultant animal’s milk contained the spider silk protein which was then extracted following milking. After that the task got harder.\nSo far, what has held scientists back, says Michelle Oyen, professor of Mechanics of Biological Materials at the University of Cambridge, is understanding the natural materials well enough to mimic them. “In the case of spider silk, we can copy the gene sequences responsible for silk and transfer them elsewhere, as with the goat’s milk case,” she says. “But we then have to mimic the spider’s silk spinneret in order to form the proteins into fibers, and that’s tricky and has been one of the limitations to date.”\nSpiber, capitalized at 780 million yen, is now capable of producing up to 1 kg of the silk protein a day and is confident enough to form a joint venture with a Toyota (TM) subsidiary to commercialize production.\nThe Latest Bing News on:\nSynthesizing spider thread\n- Are Hydrogen Cars Still Happening?on June 15, 2021 at 5:00 pm\nPotentially coming to a service station near you. In every comment section, there’s always one. No matter the electric vehicle, no matter how far the technology has come, there’s always one.\n- 30 Years Later TED Finds His Voice: A Commodore Story Part Ion June 14, 2021 at 5:01 pm\nThis office was unlike any other office. This office had a large collection of spider plants. I felt blessed to be working at Commodore and even more so sitting in the only office with green ...\n- First Synthetic Spider Silk Developed That’s Suitable for Industrial Useon June 5, 2021 at 5:00 pm\nSpider silk long has been a coveted material for scientists to synthesize because it is at the same time ... Institutet now has found success in fabricating kilometer-long threads of synthetic spider ...\n- It’s time to consign the “selfish gene” to the history bookson May 30, 2021 at 5:12 pm\nThe same is true for spiders, whose reliance on web construction favors offspring who can produce sticky threads and react to vibrations on the web. Plants are equally effective in producing their ...\n- Mass Effect: Who Made the Reapers? Answeredon May 26, 2021 at 11:00 am\nWhen any form of organic life reached a certain stage of evolution, it’d send the Reapers in to eliminate it or synthesize it into new Reapers. They’d use their indoctrination ability to ...\n- 5. Final Fantasy IX Village of Dali to Gargan Rooon April 23, 2021 at 12:47 pm\nEnter the church, climb up the ladder to find a Leather Plate. Synthesize items here as much as you like but keep one gear item of any kind so you do not miss any Abilities to learn. Take the ...\n- 20. KINGDOM HEARTS - HD 1.5+2.5 ReMIX KH1: Synthesis Guideon January 8, 2021 at 1:01 am\nThe following list contains all synthesis items, organized alphabetically by name. It shows the minimum quantity Sora needs to synthesize all items once. \"Enemy Drop?\" tells you what enemies will ...\n- Billions of Dollars Are Being Spent to Perfect the Engineering of Lifeon May 10, 2017 at 4:13 pm\nThe burgeoning field combines genomics and the chemical synthesis of DNA ... but in drawing investment. Bolt Threads of California recently debuted yeast-derived spider’s silk in the form ...\n- Bridges Conference: Marlboro graduate students building connection through languageon August 24, 2016 at 7:28 pm\nWe went around the circle and physically tied threads between presenters and named the links we saw between their work. Slowly we formed what looked like the spokes of a wheel or a spider web. Kara ...\n- Synthetic biology inches toward the mainstreamon October 17, 2008 at 5:00 am\n\"Spiders make threads that are stronger than steel ... launched on the gene synthesis market just a few years before the completion of the 13-year Human Genome Project (which consisted primarily ...\nThe Latest Google Headlines on:\nSynthesizing spider thread\nThe Latest Bing News on:\n- 'Ballooning' spiders leave behind sea of silk after flood in Australiaon June 16, 2021 at 11:01 am\nUsing a behavior called \"ballooning,\" spiders clambered atop vegetation and flung fine silk threads into the wind; as the threads caught air, the spiders got plucked from their perches and lifted to ...\n- Spider-inspired Silk Company, Spintex, Awarded $100,000 Ray of Hope Prizeon June 16, 2021 at 8:45 am\nBy mimicking how a spider spins silk at room temperature, Spintex creates high performance, sustainable textiles that are 1,000 times more efficient than an equivalent synthetic fiber.\n- University of Cambridge Funds Vegan Spider Silk to Replace Single-Use Plastic Packagingon June 16, 2021 at 8:07 am\nWhat is vegan spider silk? Packaging is one of the leading contributors to planet Earth's waste, so scientists are looking to this sustainable material.\n- Scientists say spider silk could teach us how to replace plasticon June 16, 2021 at 4:00 am\nChemists and engineers have studied spider silk for years to figure out if it could be adapted in developing novel materials. Now, an intriguing new paper has a remarkable proposal: use a ...\n- We’ve got a plastic problem — and spider silk may be the solutionon June 15, 2021 at 5:10 am\nProducing sustainable packaging materials, using natural resources and less energy consumption could reduce the amount of plastic going into landfill.\n- This 'Vegan Spider Silk' Could Replace Most Single-Use Plasticson June 14, 2021 at 1:28 pm\nResearchers from the University of Cambridge may have a viable solution to the single-use plastic dilemma: spider silk. Or, more accurately, a plant-based synthetic polymer that m ...\n- Plant-Based “Vegan Spider Silk” Provides Sustainable Alternative to Single-Use Plasticson June 12, 2021 at 1:24 am\nResearchers have created a plant-based, sustainable, scalable material that could replace single-use plastics in many consumer products. The researchers, from the University of Cambridge, created a ...\n- New material inspired by spider silk could help solve our plastic problemon June 11, 2021 at 6:30 am\nPlastics are very useful materials. They've contributed significant benefits to modern society. But the unprecedented amount of plastics produced over the past few decades has caused serious ...\n- \"Vegan spider silk\" offers a plant-based replacement for common plasticon June 10, 2021 at 7:46 pm\nBy mimicking the self-assembling microstructures that give spider silk its incredible strength, scientists at the University of Cambridge have produced a plant-based film with the strength of common ...\n- Eensy Weensy Spider Silk Takes the Temperature of a Single Cellon June 10, 2021 at 12:20 pm\nEven though he works with spiders regularly, Yao Zhang, a physicist at Jinan University in China, admits he's afraid of them. In fact, most of the people in his lab are, except for graduate student ...", "label": "Yes"}
{"text": "The tick was fat with blood before it died, having just feasted on a monkey. But searching fingers likely found the bug nestled in its host's fur during a grooming ritual.\nPrimates bond by picking at each other to look for parasites. That practice is good for the health of a monkey community, but it was very bad for the ancient tick that ended up flung aside and caught in tree sap.\nEngorged with blood and strained from being plucked roughly from its host, the bug's body burst. As it died, two small holes in its back leaked monkey blood into the sticky grave.\nThat bit of tree sap hardened into amber over the next 20 to 30 million years, and recently emerged from a mine in the Dominican Republic. It has now made its way to a laboratory at Oregon State University.\nUnder a microscope, those squirts of blood were found to be the first fossilized red blood cells from a mammal ever discovered — and they give key insights into life in the ancient Hispaniolan forest.\nThe biologist George Poinar Jr. examined the fossil, filing down the amber down so that the ancient arachnid was just five-hundredths of a millimeter from the surface. The blood that leaked from those two holes on its back was spread out and naturally stained in the congealed sap, almost as if prepared for examination in a lab. Poinar could tell the blood came from a monkey based on the shape and diameter of the cells.\nBut mixed into the blood was another parasite even smaller than the tick: Babesia microti, a protozoan parasite that's still around today.\nB. microti still travels in ticks, and infects primates when its host sucks their blood. In humans, it causes a malaria-like disease called babesiosis.\nWhen Poinar cracked the tick fossil open after thoroughly studying the intact bug, he found b. microti at all of its several life stages in the tick's gut.\nThe discovery of this ancient b. microti, beautifully preserved in amber, gives researchers a new minimum earliest date for the emergence of the parasite. And the whole fossil, tiny as it is, therefore tells a complex story about the life cycles of creatures living in the Caribbean islands millions of years ago.", "label": "Yes"}
{"text": "Fatigue associated with an emotional shock can lead to reactional hair loss, known as “acute telogen effluvium”. It usually appears three to four months after a triggering factor. The hair cycle is thus disrupted, triggering an abrupt, diffuse and simultaneous loss of hair in the telogen phase.\nCan you lose hair from lack of sleep?\nA lack of sleep can also create stress on your body which increases your chance of telogen effluvium, a significant, albeit potentially temporary, loss of hair on your scalp.\nWhy am I suddenly losing so much hair?\nPossible causes of hair loss include stress, poor diet, and underlying medical conditions. Everyone experiences hair shedding, and it happens to each of us every day. Most people lose 50 to 100 hairs per day as part of this natural cycle, more on days you wash your hair.\nHow can I stop my hair from falling out due to stress?\nStress and Hair Loss: Potential Ways to Cope\n- Learn and practice relaxation techniques (such as deep breathing, meditation, or yoga) regularly.\n- Get regular exercise, which helps manage stress and its effects.\n- Spend time with positive people — isolating yourself can make stress worse.\n- Seek professional help from a therapist.\nCan dehydration cause hair loss?\nSevere dehydration may even accelerate hair loss. If you notice your hair beginning to thin or fall out in larger quantities than usual, increasing your daily water and vitamin intake should help. It’s also beneficial to use a moisturizing conditioner and avoid blow drying your hair until its moisture content improves.\nWill hair loss from stress grow back?\nExcessive hair loss from stress typically stops when the stress stops. Hair will likely regrow to its normal fullness in 6 to 9 months without any treatment.\nWhat illness causes hairloss?\nMedical conditions that can cause hair loss include: thyroid disease. alopecia areata (an autoimmune disease that attacks hair follicles) scalp infections like ringworm.\nHair loss can also be due to medications used to treat:\n- high blood pressure.\n- heart problems.\nWhat lack of vitamin causes hair loss?\nResearch shows that a lack of vitamin D in your body can lead to hair loss. One role vitamin D plays is stimulating new and old hair follicles. When there isn’t enough vitamin D in your system, new hair growth can be stunted.\nCan anxiety cause hair shedding?\nAlthough the hair will grow back, continued anxiety and stress can cause the hair loss to continue leading to different patches of hair and baldness. Telogen Effluvium (TE). This is the second most common form of hair loss. In essence, it occurs when there is a change in the number of hair follicles growing hair.\nWhat does stress hair loss look like?\nPatchy hair loss or widening of the part line is generally suggestive of other diagnoses, like alopecia areata or female pattern hair loss. Individuals experiencing telogen effluvium may notice a thinner ponytail, or a sudden increase of shed hairs in the shower, on the pillowcase, or around the house.\nWhat vitamin should you take for hair loss?\nOne of the best known vitamins for hair growth is a B vitamin called biotin. Studies link biotin deficiency with hair loss in humans ( 5 ). Although biotin is used as an alternative hair loss treatment, those who are deficient have the best results.\nCan drinking water stop hair loss?\nDrinking water helps hair health by preventing many hair problems. Drinking enough water keeps your hair hydrated. As such, one can truly avoid hair loss, hair fall, dry hair, brittle hair and itchiness. Your scalp remains hydrated and healthy by having the correct amount of water in the diet.\nDoes drinking water increase hair growth?\nWater is a key ingredient that supports vitamins, which contribute to your hair growth. Believe it or not, but water makes up almost 25% of the weight of a single strand of hair. Drinking at least two liters of water a day will help the strength of your hair, increasing growth.\nCan drinking water reverse hair loss?\nWater hydrates the hair cells, makes them work the way they are supposed to and this helps your hair grow long and strong. Not just that, it stays in place too. And with hydration, you help keep away hair loss. Staying hydrated thus has huge hair benefits.", "label": "Yes"}
{"text": "Tuesday, May 4, 2010\nNew Safe Chemicals Act Mandates Reduced Animal Testing\nThe new Safe Chemicals Act of 2010 (SCA), introduced recently by Senator Frank Lautenberg with a companion bill in the House, includes several concepts that are not currently part of the Toxic Substances Chemical Act (TSCA) that it seeks to reform. One of those differences is the inclusion of a mandate to reduce animal testing.\nSection 31 of the SCA states that EPA \"shall take action to minimize the use of animals in testing of chemical substances and mixtures.\" This includes:\n1) Encouraging and facilitating a) use of existing data of sufficient scientific quality, b) use of test methods that eliminate or reduce the use of animals but provide data of high scientific quality, c) grouping of two or more chemicals into scientifically appropriate categories where data on one substance will provide reliable and useful data on others, d) formation of industry consortia to jointly conduct testing to avoid unnecessary duplication, and e) parallel submission of testing from animal based studies and from emerging methods and models.\nThose familiar with REACH might recognize a similar approach. The idea is to provide scientifically defensible data in the most efficient manner, so that modeling, read-across, alternative testing, and other methods can be used to meet the data requirements. The bottom line means less animal testing. The consortium idea also comes from the HPV Challenge days.\nIn addition, the section also authorizes:\n2) the funding of research and validation of studies to reduce, refine, and replace (i.e., the \"3 Rs\") the use of animal tests.\nThe section also goes into some detail about an \"Interagency Science Advisory Board on Alternative Testing Methods\" that EPA shall establish within 90 days after enactment. The Board would consist of representatives from several key programs such as the NIEHS, CDC, NTP, NCI, NTSC and others. [Sorry for the acronyms, but I can define them if anyone doesn't already know what they mean.] The EPA, with input from the Board, would have one year to publish a list of testing methods that reduce the use of animals in testing. EPA and the Board would also promote the development of new testing methods that are not animal based. Finally, the section gives EPA some flexibility to waive testing requirements if there is sufficient weight-of-evidence from other sources.\nSo all in all there is an effort to reduce animal testing. That said, it is highly likely that animal testing will remain a key tool in the evaluation of hazard and risk. At least until sufficient non-animal methods have been developed and validated, a process that will likely take a long, long time.", "label": "Yes"}
{"text": "Odorants are volatile and largely hydrophobic organic compounds possessing odors while\nodorless compounds are chemicals which do not possess or are associated with any odor.\nOlfactionBase comprises of 3985 odorant molecules representing an array of odors and 1124\nodorless compounds. Odorant molecules are classified by 30 functional groups such as (acid,\nalcohol, aldehyde, alkane, cyclic, ether, ester, ketone, thiol, etc.). Each molecule entry\nincludes detail information about physicochemical properties, odor profile, pharmacokinetic\nprofile and drug likeness and cross-references to other biological databases. Among 3985\nodorant molecules, 197 molecules are associated with 156 Olfactory receptors belonging to\ntwo species (Human and Mus musculus). The user-friendly interface of Olfactionbase\nfacilitates exploration of chemicals in various ways: search chemical compounds with CAS\nNo., odor and sub-odors, functional group, SMILES notation and molecular weight.", "label": "Yes"}
{"text": "4% chlorhexidine soapy gel\nHygiene, antisepsis and skin care.\nBactiScrub is an antiseptic gel of 4% soapy chlorhexidine for hygiene and antisepsis. The gel format ensures greater dermal absorption of chlorhexidine.\nIt is a solution for both antiseptic washing of the patient’s skin (surgical, intensive and colonized) and pre-surgical antiseptic cleansing of hands and forearms of the healthcare personnel.\nAntiseptic patient’s body wash. Hands and forearms pre-surgical scrub for healthcare personnel.", "label": "Yes"}
{"text": "Arguments for advantages of genetically modified foods various countries such as philippines and china began manufacturing genetically modified foods to help in solving the food crisis in the world gmos can be produced to mature faster compared to natural foods. The number of genetically modified animals used in agriculture has increased significantly in recent years researchers have genetically engineered a number of mammals, from laboratory animals to farm animals, as well as birds, fish and insects. Importance of technology in agriculture: they are used to harvest the crops in the production of genetically modified crops new varieties of fertilizers and pests can be produced. The food and agriculture organization of the united nations also says that farmers can grow more food on less land with genetically modified crops genetically modified animals have certain genes inserted into their genomes so that they can produce 'better' milk, eggs, and meat.\nThis purpose of this essay is to discuss the most likely advantages and problems that arise from the introduction of genetically modified (gm) agricultural crops this will be done by comparing the main arguments and issues for and against. No genetically modified microorganism is currently used in foods although some are used to produce food ingredients the safety evaluation of gmm-derived food additives and processing aids should place special emphasis on the detection of possible unintended effects. Benefits of genetically modified organisms genetically modified organisms (gmo) refers to plants or crops that have been modified using molecular biology techniques these plants are modified in labs or research centers with the intention of enhancing its desired traits such as pest resistance, enhancing nutrition, etc. Gmo's, or genetically modified organisms, is a form of scientific farming where crops are pumped full of chemicals to increase yield and size of crops it is highly debated and becoming more and more common in everyday foods.\nGenetically modified (gm) crops have many potential advantages in terms of raising agricultural productivity and reducing the need for (environmentally harmful) pesticides they might also pose hazards to human health, from toxicity and increased risk of allergies, for example. The un food and agricultural organization notes that rice, genetically modified to produce high levels of vitamin a, have helped to reduce global vitamin deficiencies 3 genetically modified foods can have a longer shelf life. Genetically modified (or gm) plants have attracted a large amount of media attention in recent years and continue to do so despite this, the general public remains largely unaware of what a gm plant actually is or what advantages and disadvantages the technology has to offer, particularly with.\nGenetically modified produce can be harvested when ripe, and the ripening process stops, giving them a longer shelf life these genetic modifications also increase a plant's resistance to disease, pests, insecticides, herbicides and even extreme weather conditions. Genetically modified foods, which are often referred to in a general classification called gmos, have changed the grocery marketplace genetic modifications are a natural component of evolution even in the past, before technologies allowed for specific modifications, agricultural workers. Advantages and problems of genetically modified agricultural crops 681 words 3 pages genetically modified food (gm) is most commonly used to refer to crop plants created for human or animal consumption, using the latest molecular biology techniques.\nGm crops and the environment the debate over the environmental impact of genetically modified (gm) crops is growing increasingly complex, intense, and extremely emotional it is further complicated as new research is published. Advantages and problems of genetically modified agricultural crops genetically modified food (gm) is most commonly used to refer to crop plants created for human or animal consumption, using the latest. The benefits of genetically modified crops should be compared to those of other means of agricultural intensification such as organic farming, integrated pest management and agricultural policy reform.\nThose in support of genetically modified foods have noted the significant role that gm foods could play in fighting malnutrition in the developing world which, according to the united nations food and agriculture organization, affects nearly one out of eight people on earth. List of cons of genetically modified crops 1 they are not entirely believed to be safe truth is, there are also a number of independent studies of the health effects of genetically modified crops that do not have confidence in their safety. - advantages and problems of genetically modified agricultural crops genetically modified food (gm) is most commonly used to refer to crop plants created for human or animal consumption, using the latest molecular biology techniques.", "label": "Yes"}
{"text": "People face a number of health issues and the number of such issues reported only seems to be increasing by the day. One cannot decide if the numbers are increasing due to changing lifestyle and more issues being identified or is it just the awareness created, that makes people come forward.\nWhat Is A Disease\nA disease is something one develops at any point in their life. It is caused by some factor the body is unable to control. There are cures for many diseased and many diseases are yet to have an effective cure.\nCancer and AIDS are diseases like plague or small pox. The intensity of any disease varies based on where it originates and how soon an antibody is found. Diseases can be cured, thanks to the advancement in science and technology. Today, one only has to report a few symptoms and the systems are so updated and fast, that they can find or at least narrow down the search for the disease.\nWhat Is Disorder\nA disorder is caused due to the malfunctioning or lack of functioning of some parts in the body. When the human body does not go through the formation process as it should, it leads to disorders. When a fetus does not get the sufficient nutrients or chromosomes as it should, it results in disorders.\nDiabetes is a disorder caused due to the malfunctioning of the pancreas that is supposed to produce the insulin for the body. In most cases, disorders don’t have a permanent solution. They have remedies that can help the situation but no solution that can remove the entire disorder. Though one can undergo treatment and reduce the symptoms of Down syndrome, there is not permanent cure for it.\nIn many cases, people confuse disorders with diseases and think they are equally treatable. A search online about disorders and diseases will give you many results and information.", "label": "Yes"}
{"text": "Do cranberry capsules reduce the consumption of antibiotics for symptoms of acute uncomplicated urinary tract infections? A feasibility study.\n- Principal Investigator: Kome Gbinigie\n- 1 July 2018 to 30 June 2020\n- Project No: 413\n- Funding round: FR 16\nUrinary tract infections (UTIs) are the commonest bacterial infections affecting women, and are usually treated with antibiotics. Because of frequent and sometimes inappropriate use of antibiotics, many bacteria have adapted so that they are no longer killed by antibiotics (antibiotic resistance). As a result, there has been increasing interest in using non-antibiotic treatments, such as cranberry extract. The sugars in cranberries are believed to prevent bacteria from sticking to the wall of the bladder, thus reducing the ability of bacteria to cause and sustain a UTI. Cranberries might also make it easier for antibiotics to surround and kill bacteria.We will conduct a study to assess whether cranberries can treat UTIs in women and safely reduce antibiotic use. Women with a UTI will be invited to take part. We will not include women with complicated UTIs (e.g. feverish, back pain, vomiting).\nWomen will be randomly assigned to one of three groups:\n1) Usual treatment with antibiotics.\n2) Treatment with antibiotics AND cranberry capsules.\n3) Initial treatment with cranberry capsules, but also with an antibiotic prescription that they can take to the chemist at a later date if they don’t get better with cranberry alone (‘back-up antibiotics’).\nParticipants will complete a diary daily for up to two weeks about their symptoms (e.g. pain on passing urine), how bad the symptoms are, how long they last, and whether or not they take antibiotics.The main aim of this small-scale study is to test whether the study design described works and is acceptable to participants (called a feasibility study). This will help in the planning of a subsequent, similar, but much larger study. By comparing the information from different treatment groups on a larger scale, we will be able to tell whether cranberries actually treat UTIs and help reduce the need for antibiotics.", "label": "Yes"}
{"text": "Vollman lands NIH mentored scientist award\nMichael Vollman, Ph.D., R.N., assistant professor of Nursing, was recently awarded a three-year Mentored Research Scientist Award by the National Institutes of Health's National Institute of Nursing Research.\n“Michael's passion for research is infectious,” said Peter Buerhaus, Ph.D., R.N., senior associate dean for Research at Vanderbilt University School of Nursing. The $259,000 award will fund longitudinal research that focuses on the relationships among coping strategies, depressive symptoms, sympathetic nervous system activation and inflammatory cytokine activity as potential pathways affecting morbidity and mortality in adult patients diagnosed with heart failure.\nVollman's award will also fund advanced training in the measurement of biomarkers in clinical research, molecular and cellular immunology, and longitudinal data modeling techniques.", "label": "Yes"}
{"text": "I know there are a lot of threads out there on this site and elsewhere, but I haven't been able to find anything that matches our situation and was hoping to get some advice based on what's going on. We have four ducks that are four months old now. A month ago, we bought three Buff hens that are about a year old. Everyone adjusted well and acted as though they had been a family all along. Although their food was changed as soon as they moved in to duck feed from the chicken feed they'd been getting, all three Buffs laid and egg almost every day for the first two weeks. At that point, one of them became very broody, to the point that we have to scoot her out of the house to get her to take a daily swim. She's sitting on a nest of 18 eggs and is in a very bad temper. Once she started sitting on the nest she'd made for the eggs, all three Buffs stopped laying. That's the only thing I can think of that coincided with them all stopping the laying. No changes in food, environment, routine. They all seem healthy and active, so I just don't know what to think. Many thanks in advance for any advice!", "label": "Yes"}
{"text": "AOR ZINC COPPER BALANCE - VEGETABLE CAPSULES 17MG 100 S\nA balanced ratio of two key minerals.Addresses zinc deficiency while reducing the risk of excess zinc.Supports healthy skin, prostate and immunity.\nClinically backed ratio of zinc to copper.\nGluten Free // Non-GMO // Vegan\nAOR is Proudly Canadian.\nTransform health through evidence-based, natural and therapeutic products offered by AOR.", "label": "Yes"}
{"text": "Sea turtles are live witnesses of innumerable geological events in the history of our planet. These sea animals are descendants from relatives who existed more than 100 million years ago; since then they have survived massive extinctions, ice ages, and thaws.\nThese millennial beings have shared their space with humanity; however, now they are threatened or in danger of extinction and are protected by Mexican laws (NOM-059-SEMARNAT-2010).\nPresently, sea turtles are facing threats including badly planned touristic development in their nest areas. Beach furniture, seawalls, and plastic garbage make it difficult for the females to nest and for the young to make their way to the sea. Plus, the turtles are very sensitive to light pollution: the female prefers to nest on dark beaches, and the light from hotels can illuminate long extensions of beach, forcing her to look for a less suitable place. Instinctively, as soon as the baby turtles leave the nest, they are guided by the light of the moon reflected in the shininess of the sea, to lead them to the ocean and the beginning of their journey. But with the bright lights of the hotels and streetlights, they become disoriented and move toward land where they die of dehydration or exhaustion, or they are eaten by predators or run over. If you live near or visit a nesting beach, you can help to protect the sea turtles and their babies by turning off exterior lights every night, and adding shades to your illumination to direct the light toward the the floor and not toward the beach. You can also remove furniture or any other physical obstacle on the beach every evening. If you are staying at a hotel you can ask them to follow these instructions.\nThe Península of Yucatán is an important nest area for three sea turtles species: loggerhead (Caretta caretta), white (Chelonia mydas) and tortoiseshell (Eretmochelys imbricata). Pronatura Península de Yucatán has been working on sea turtle conservation at the beaches of Celestún, Las Coloradas, El Cuyo and Holbox, with the collaboration of the National Commission of Natural Protected Areas (CONANP). Every year, the nesting season begins in April and lasts until September or October. The eclosion season, when the young ones begin leaving the nest, starts in June, and with a little luck you will be able to see some of them walking to the sea at dawn or dusk. If you would like to know more about the species, write to us at [email protected].\nBy Pronatura Península de Yucatán\nEsta entrada también está disponible en: ES", "label": "Yes"}
{"text": "If you are a regular on our podcasts/blog, then this is an article that would perhaps be of interest to you\nCan the Brain Be Rebooted to Stop Drug Addiction?: Scientific American\nScientists for the first time have identified long-term changes in mice brains that may shed light on why addicts get hooked on drugs—in this case methamphetamines—and have such a tough time kicking the habit. The findings, reported in the journal Neuron, could set the stage for new ways to block cravings—and help addicts dry out.\nResearchers, using fluorescent tracer dye, discovered that mice given methamphetamines for 10 days (roughly equivalent to a human using it for two years) had suppressed activity in a certain area of their brains. Much to their surprise, normal function did not return even when the drug was stopped, but did when they administered a single dose of it again after the mice had been in withdrawal.\nStudy co-author Nigel Bamford, a pediatric neurologist at the University of Washington School of Medicine, says that if similar changes occur in humans, it will indicate that an effective way to fight addiction may be to design therapies that target the affected area—the striatum, a forebrain region that controls movement but also has been linked to habit-forming behavior.", "label": "Yes"}
{"text": "A gene expression database\nfor the molecular pharmacology of cancer, Nature Genet.\nCIBEX: Center for Information Biology Gene Expression database\n. C R Biol 326:1079-1082.\nAccording to the 23 June 2003 edition of the online news source Bioinform, the planned internal gene expression database\nwill help educate FDA reviewers about the format, content, and context of microarray data submissions.\nThus, we anticipate that the object models built by MGED in the microarray gene expression database\narena also will be applicable to proteomics and metabonomics.\nAccording to the notification, Javed Iqbal S/o Sheer Mohammad was granted degree in the subject of Persian after approval of his thesis entitled Editing and Analysis of Diwan-E-Mirza Mohammad Sadiq Medami while Shahid-ur-Rehman S/o Saif-ur-Rehman got degree in the subject of Molecular Biology after approval of his thesis entitled Development of Standardized Laboratory Information Management System Using DNA Microarray Plant Gene Expression Databases\nLarge gene expression databases\nare available for human cells that have been treated with molecules extracted from existing drugs as well as drugs that are in development.\nIn creating the world's largest commercial gene expression databases\n- BioExpress[R] and ToxExpress[R], we have developed expertise and capabilities that are unparalleled in the genomic services industry.\nMicro-array and gene expression databases\nGene Logic provides gene expression databases\nthrough its custom discovery research databases and its GeneExpress Suite of databases.\nWith considerable investment of resources, a few full-featured, relational gene expression databases\nhave been developed, but these are not available for public deposition of data (e.g., http://genome-www4.stanford.edu/MicroArray/ MDEV/index.html; http://www.\nThe license is exclusive for the creation of gene expression databases\n, which will be licensed to others, but non-exclusive for other uses.\nTechnical and policy issues that need to be addressed include a) opportunities for shared learning in the public domain, b) accessibility to publicly held gene expression databases\n, c) understanding of the predictive capabilities of the technologies before widespread application, d) availability of prevalence data, e) privacy and confidentiality concerns, f) security and discrimination issues, g) counseling for coping with genetic information, h) use and premature use of \"omics\" data, and i) defining the regulatory positions on \"omics\" data.", "label": "Yes"}
{"text": "The human body is like a magnificent, sweaty and other body fluid precision instrument that moves and mixes chemicals in a precise and coordinated way, making memories, thoughts, blood, nails… everything that is alive. Of course, maybe these “small secrets” will make you more interested.\nFour-color mixed skin\nThe color of all races and ethnicities, the attention is all, in the beginning, it looks milky white, like a canvas that has not been dyed. The blood vessels close to the surface add a touch of red to this “canvas”. A special yellow “fuel” that comes with the gene will also color the canvas. Finally, due to the ultraviolet light, a large amount of brown melanin is produced on the surface of the skin. The skin turns black. The skin color of all the people on earth is a mixture of these four colors in different proportions, so the reason why there are no black people in Russia is probably that their ancestors in Siberia did not sunbathe every day like the indigenous tribes of the Cape of Good Hope.\nLaughing can also infect\nWhen the middle school period is the most arduous, the difficulty of class is the difficulty that every student must overcome. The yawning has become an infectious disease. The faint afternoon and a group of students with big mouths are the nightmare of each teacher. Just as you see someone yawning, you will immediately behave the same way as being infected. Recent research evidence suggests that laughter is also a social suggestion. Hearing laughter actually stimulates the relevant areas of the brain that control facial muscle activity, making people in a state of being ready to laugh, and imitation plays an irreplaceable role in human social interaction. The desire to establish social connections among groups, sneezing, laughing, weeping and yawning suggests that it may be the best “combination” scheme in human genes.\nGive way to the brain for the development of the brain\nHuman beings have evolved from apes for millions of years, forming what they are now, and can be said to be the only miracle on earth. But evolution itself is not perfect, otherwise we may have wings instead of hateful wisdom teeth. In general, the reason that the useless features exist in one species may simply be that they have no harm. The wisdom teeth that make many modern people unbearable and useless are a very convenient set of teeth in our ancestors. Only the priority of our brain evolution is too high, leading to the continuous expansion of brain capacity and increasing importance. Over time, our jaw structure has changed, our mouths have become more and more crowded, and the original functions of wisdom teeth have been new. Replaced by other sharper teeth that developed.\nCells also have “hair”\nIn most of our cells, there is an organelle called cilia that helps us to perform functions from food digestion to music appreciation. In the case of a common cold, in the nasal cavity, cilia acts as a postman. It will transport the mucus produced in the nasal cavity to the throat, and the cause of your nasal congestion is not that the secretion of mucus is too much to block the nasal passage. The real reason is that the cold weather makes your nasal mucosa bigger than usual. Double, thus occupying the passage in the nasal cavity that was originally exchanged with the outside air. The role of cilia is to transfer as much as possible the odious nose, let your swollen nose smooth.\nAdolescence is also the brain renewal period\nWhen did we start to grow up? It may be because of something, or because of a particular moment, the probability of these factors occurring between 12 and 18 years old, sociology and psychology are called puberty. In such a period of rapid physical and mental growth, the body’s hormone levels are constantly changing. Of course, this is a good thing. It promotes our body growth and prepares for future fertility.\nBut it seems that teenagers all over the world will encounter problems of one kind or another. “Unhappy” has become the main theme of their emotions, which is of course the negative effect of hormone levels. Taking sex hormones such as testosterone as an example, they actually affect the development of brain neurons, and the consequences of brain changes in neuronal structure are emotional instability, indifference, and poor decision-making ability. From a psychological point of view, it is like a mature adult in a child’s body. Adolescent teenagers always think about problems in a more adult way, but the measures they take to deal with the problem are still the same as the children. Different, the mind and body derived from the brain renewal period have become the “pain point” of adolescence.\nBurning my calories\nThe facts to be presented next may make people who are obese or obese obsessed, because in fact most of the nutrients we consume from food contribute to the brain rather than fat. Although the brain is only an electrochemical substance that accounts for 2% of the total weight of the human body, it requires the body to provide 20% of oxygen and heat. In order for the brain to get enough nutrients in time, the three major arteries continuously deliver oxygen through the red blood cells in the blood. Therefore, while maintaining the daily function of the body, our brain is also burning a lot of calories, which is called the “big stomach king” in the organs. Of course, this is by no means an excuse for turning off your treadmill and canceling your fitness program.\nBody posture affects memory\n“Is it coming to the wedding anniversary?” As a famous husband, in the face of his wife’s questioning, he must always keep a cool head, but unfortunately this time you really forgot the wedding anniversary is Which day. It doesn’t matter, trying to kneel down on your knees may help you remember the details at that time faster. Studies have found that when your body posture is similar to that presented in past activities, previous experiences and details are remembered faster and better.\nIn addition, biopsychologists also point out that memory is highly reflected in the senses of our bodies. A smell or sound can evoke a person’s memory of a long-term fragment of childhood, and the grandmother’s taste of slyness brings you an instant recall. From the small rice fields and the sloppy puppies on the roadside, these connections can be obvious, or they can be unrelated or even difficult to understand.\nYour stomach will secrete dangerous liquids\nSecurity personnel at the airport will check all the liquids you carry, and they are almost paranoid about the dangers. But there is a dangerous liquid that no security personnel can confiscate: it is in your stomach. Gastric cells secrete low levels of hydrochloric acid, a highly corrosive compound. We know that high concentrations of hydrochloric acid are used in the industry to dissolve metals, but mucus on the stomach wall can safely store this toxic liquid in the digestive system to digest three meals a day and your diet pills.", "label": "Yes"}
{"text": "Plant shoot systems give rise to characteristic above-ground plant architectures. Shoots are formed from axillary meristems and buds, whose growth and development is modulated by systemic and local signals. These cues convey information about nutrient and water availability, light quality, sink/source organ activity and other variables that determine the timeliness and competence to maintain development of new shoots. This information is translated into a local response, in meristems and buds, of growth or quiescence. Although some key genes involved in the onset of bud latency have been identified, the gene regulatory networks (GRNs) controlled by these genes are not well defined. Moreover, it has not been determined whether bud dormancy induced by environmental cues, such as a low red-to-far-red light ratio, shares genetic mechanisms with bud latency induced by other causes, such as apical dominance or a short-day photoperiod. Furthermore, the evolution and conservation of these GRNs throughout angiosperms is not well established. We have reanalyzed public transcriptomic datasets that compare quiescent and active axillary buds of Arabidopsis, with datasets of axillary buds of the woody species Vitis vinifera (grapevine) and apical buds of Populus tremula x Populus alba (poplar) during the bud growth-to-dormancy transition. Our aim was to identify potentially common GRNs induced during the process that leads to bud para-, eco- and endodormancy. In Arabidopsis buds that are entering eco- or paradormancy, we have identified four induced interrelated GRNs that correspond to a carbon (C) starvation syndrome, typical of tissues undergoing low C supply. This response is also detectable in poplar and grapevine buds before and during the transition to dormancy. In all eukaryotes, C-limiting conditions are coupled to growth arrest and latency like that observed in dormant axillary buds. Bud dormancy might thus be partly a consequence of the underlying C starvation syndrome triggered by environmental and endogenous cues that anticipate or signal conditions unfavorable for sustained shoot growth.\nTarancón, C., González-Grandío, E., Oliveros, J. C., Nicolas, M., & Cubas, P. (2017). A conserved carbon starvation response underlies bud dormancy in woody and herbaceous species. Frontiers in Plant Science, 8. https://doi.org/10.3389/fpls.2017.00788", "label": "Yes"}
{"text": "The story of how a little space probe slingshotted through space to visit the King of the Ice Dwarfs.\nIs this technology really the best fit for patients who are mentally ill?\nMatTek grows thousands of dime-sized pieces of skin in plastic dishes that add up, altogether, to about two whole adult humans’ worth.\nPrecision medicine---and two terabytes of genomic data---saved one man's life.\nThis fall, farmers are harvesting 50,000 acres of the cotton planted with a microbial spray designed to improve yields in low-water conditions.\nNo one has ever cut a giant hole in a bagel-shaped glass roof and dropped water nine stories in the ground. Until Singapore's Changi Airport called on a water design firm called WET.\nBy adding digestive juices, scientists have finally figured out how to grow norovirus in a petri dish—opening up a path for important health research.\nArtists, activists, and journalists now see VR’s potential to be an empathy engine.\nCounsyl is one of the first fully-automated genetic testing labs in the country.\nIllumina, the world's largest DNA sequencer company, is incubating some new companies in an effort to broaden the base of genome research.", "label": "Yes"}
{"text": "Using NMR and molecular dynamics to link structure and dynamics effects of the universal base 8-aza, 7-deaza, N8 linked adenosine analog.\nABSTRACT: A truly universal nucleobase enables a host of novel applications such as simplified templates for PCR primers, randomized sequencing and DNA based devices. A universal base must pair indiscriminately to each of the canonical bases with little or preferably no destabilization of the overall duplex. In reality, many candidates either destabilize the duplex or do not base pair indiscriminatingly. The novel base 8-aza-7-deazaadenine (pyrazolo[3,4-d]pyrimidin- 4-amine) N8-(2'deoxyribonucleoside), a deoxyadenosine analog (UB), pairs with each of the natural DNA bases with little sequence preference. We have utilized NMR complemented with molecular dynamic calculations to characterize the structure and dynamics of a UB incorporated into a DNA duplex. The UB participates in base stacking with little to no perturbation of the local structure yet forms an unusual base pair that samples multiple conformations. These local dynamics result in the complete disappearance of a single UB proton resonance under native conditions. Accommodation of the UB is additionally stabilized via heightened backbone conformational sampling. NMR combined with various computational techniques has allowed for a comprehensive characterization of both structural and dynamic effects of the UB in a DNA duplex and underlines that the UB as a strong candidate for universal base applications.\nProject description:Universal bases hybridize with all other natural DNA or RNA bases, and have applications in PCR and sequencing. We have analysed by nuclear magnetic resonance spectroscopy the structure and dynamics of three DNA oligonucleotides containing the universal base analogues 5-nitroindole and 5-nitroindole-3-carboxamide. In all systems studied, both the 5-nitroindole nucleotide and the opposing nucleotide adopt a standard anti conformation and are fully stacked within the DNA duplex. The 5-nitroindole bases do not base pair with the nucleotide opposite them, but intercalate between this base and an adjacent Watson-Crick pair. In spite of their smooth accommodation within the DNA double-helix, the 5-nitroindole-containing duplexes exist as a dynamic mixture of two different stacking configurations exchanging fast on the chemical shift timescale. These configurations depend on the relative intercalating positions of the universal base and the opposing base, and their exchange implies nucleotide opening motions on the millisecond time range. The structure of these nitroindole-containing duplexes explains the mechanism by which these artificial moieties behave as universal bases.\nProject description:Helicases couple the chemical energy of ATP hydrolysis to directional translocation along nucleic acids and transient duplex separation. Understanding helicase mechanism requires that the basic physicochemical process of base pair separation be understood. This necessitates monitoring helicase activity directly, at high spatio-temporal resolution. Using optical tweezers with single base pair (bp) resolution, we analyzed DNA unwinding by XPD helicase, a Superfamily 2 (SF2) DNA helicase involved in DNA repair and transcription initiation. We show that monomeric XPD unwinds duplex DNA in 1-bp steps, yet exhibits frequent backsteps and undergoes conformational transitions manifested in 5-bp backward and forward steps. Quantifying the sequence dependence of XPD stepping dynamics with near base pair resolution, we provide the strongest and most direct evidence thus far that forward, single-base pair stepping of a helicase utilizes the spontaneous opening of the duplex. The proposed unwinding mechanism may be a universal feature of DNA helicases that move along DNA phosphodiester backbones. DOI:http://dx.doi.org/10.7554/eLife.00334.001.\nProject description:A cationic 7-aminomethyl-7-deaza-2'-deoxyguanosine (7amG) was incorporated site-specifically into the self-complementary duplex d(G¹A²G³A?X?C?G?C?T?C¹?T¹¹C¹²)? (X = 7amG). This construct placed two positively charged amines adjacent to the major groove edges of two symmetry-related guanines, providing a model for probing how cation binding in the major groove modulates the structure and stability of DNA. Molecular dynamics calculations restrained by nuclear magnetic resonance (NMR) data revealed that the tethered cationic amines were in plane with the modified base pairs. The tethered amines did not form salt bridges to the phosphodiester backbone. There was also no indication of the amines being capable of hydrogen bonding to flanking DNA bases. NMR spectroscopy as a function of temperature revealed that the X? imino resonance remained sharp at 55 °C. Additionally, two 5'-neighboring base pairs, A?:T? and G³:C¹?, were stabilized with respect to the exchange of their imino protons with solvent. The equilibrium constant for base pair opening at the A?:T? base pair determined by magnetization transfer from water in the absence and presence of added ammonia base catalyst decreased for the modified duplex compared to that of the A?:T? base pair in the unmodified duplex, which confirmed that the overall fraction of the A?:T? base pair in the open state of the modified duplex decreased. This was also observed for the G³:C¹? base pair, where ?K(op) for the G³:C¹? base pair in the modified duplex was 3.0 × 10? versus 4.1 × 10? for the same base pair in the unmodified duplex. In contrast, equilibrium constants for base pair opening at the X?:C? and C?:G? base pairs did not change at 15 °C. These results argue against the notion that electrostatic interactions with DNA are entirely entropic and suggest that major groove cations can stabilize DNA via enthalpic contributions to the free energy of duplex formation.\nProject description:Human genomic samples are complex and are considered difficult to assay directly without denaturation or PCR amplification. We report the use of a base-specific heteropolymeric triplex, formed by native duplex genomic target and an oligonucleotide third strand probe, to assay for low copy pathogen genomes present in a sample also containing human genomic duplex DNA, or to assay human genomic duplex DNA for Single Nucleotide Polymorphisms (SNP), without PCR amplification. Wild-type and mutant probes are used to identify triplexes containing FVL G1691A, MTHFR C677T and CFTR mutations. The specific triplex structure forms rapidly at room temperature in solution and may be detected without a separation step. YOYO-1, a fluorescent bis-intercalator, promotes and signals the formation of the specific triplex. Genomic duplexes may be assayed homogeneously with single base pair resolution. The specific triple-stranded structures of the assay may approximate homologous recombination intermediates, which various models suggest may form in either the major or minor groove of the duplex. The bases of the stable duplex target are rendered specifically reactive to the bases of the probe because of the activity of intercalated YOYO-1, which is known to decondense duplex locally 1.3 fold. This may approximate the local decondensation effected by recombination proteins such as RecA in vivo. Our assay, while involving triplex formation, is sui generis, as it is not homopurine sequence-dependent, as are \"canonical triplexes\". Rather, the base pair-specific heteropolymeric triplex of the assay is conformation-dependent. The highly sensitive diagnostic assay we present allows for the direct detection of base sequence in genomic duplex samples, including those containing human genomic duplex DNA, thereby bypassing the inherent problems and cost associated with conventional PCR based diagnostic assays.\nProject description:Two novel DNA base surrogate phosphoramidites 1 and 2, based upon relatively electron-rich 1,5-dialkoxynaphthalene (DAN) and relatively electron-deficient 1,4,5,8-naphthalenetetracarboxylic diimide (NDI), respectively, were designed, synthesized, and incorporated into DNA oligonucleotide strands. The DAN and NDI artificial DNA bases were inserted within a three-base-pair region within the interior of a 12-mer oligonucleotide duplex in various sequential arrangements and investigated with CD spectroscopy and UV melting curve analysis. The CD spectra of the modified duplexes indicated B-form DNA topology. Melting curve analyses revealed trends in DNA duplex stability that correlate with the known association of DAN and NDI moieties in aqueous solution as well as the known favorable interactions between NDI and natural DNA base pairs. This demonstrates that DNA duplex stability and specificity can be driven by the electrostatic complementarity between DAN and NDI. In the most favorable case, an NDI-DAN-NDI arrangement in the middle of the DNA duplex was found to be approximately as stabilizing as three A-T base pairs.\nProject description:Several cellular processes involve alignment of three nucleic acids strands, in which the third strand (DNA or RNA) is identical and in a parallel orientation to one of the DNA duplex strands. Earlier, using 2-aminopurine as a fluorescent reporter base, we demonstrated that a self-folding oligonucleotide forms a recombination-like structure consistent with the R-triplex. Here, we extended this approach, placing the reporter 2-aminopurine either in the 5'- or 3'-strand. We obtained direct evidence that the 3'-strand forms a stable duplex with the complementary central strand, while the 5'-strand participates in non-Watson-Crick interactions. Substituting 2,6-diaminopurine or 7-deazaadenine for adenine, we tested and confirmed the proposed hydrogen bonding scheme of the A*(T.A) R-type triplet. The adenine substitutions expected to provide additional H-bonds led to triplex structures with increased stability, whereas the substitutions consistent with a decrease in the number of H-bonds destabilized the triplex. The triplex formation enthalpies and free energies exhibited linear dependences on the number of H-bonds predicted from the A*(T.A) triplet scheme. The enthalpy of the 10 nt long intramolecular triplex of -100 kJ x mol(-1) demonstrates that the R-triplex is relatively unstable and thus an ideal candidate for a transient intermediate in homologous recombination, t-loop formation at the mammalian telomere ends, and short RNA invasion into a duplex. On the other hand, the impact of a single H-bond, 18 kJ x mol(-1), is high compared with the overall triplex formation enthalpy. The observed energy advantage of a 'correct' base in the third strand opposite the Watson-Crick base pair may be a powerful mechanism for securing selectivity of recognition between the single strand and the duplex.\nProject description:A universal base that is capable of substituting for any of the four natural bases in DNA would be of great utility in both mutagenesis and recombinant DNA experiments. This paper describes the properties of oligonucleotides incorporating two degenerate bases, the pyrimidine base 6H,8H-3,4-dihydropyrimido[4,5-c][1,2]oxazin-7-one and the purine base N6-methoxy-2,6-diaminopurine, designated P and K, respectively. An equimolar mixture of the analogues P and K (called M) acts, in primers, as a universal base. The thermal stability of oligonucleotide duplexes were only slightly reduced when natural bases were replaced by P or K. Templates containing the modified bases were copied by Taq polymerase; P behaved as thymine in 60% of copying events and as cytosine in 40%, whereas K behaved as if it were guanine (13%) or adenine (87%). The dUTPase gene of Caenorhabditis elegans, which we have found to contain three nonidentical homologous repeats, was used as a model system to test the use of these bases in primers for DNA synthesis. A pair of oligodeoxyribonucleotides, each 20 residues long and containing an equimolar mixture of P and K at six positions, primed with high specificity both T7 DNA polymerase in sequencing reactions and Taq polymerase in PCRs; no nonspecific amplification was obtained on genomic DNA of C. elegans. Use of P and K can significantly reduce the complexity of degenerate oligonucleotide mixtures, and when used together, P and K can act as a universal base.\nProject description:DNA damage that stalls replicative polymerases can be bypassed with the Y-family polymerases. These polymerases have more open active sites that can accommodate modified nucleotides. The lack of protein-DNA interactions that select for Watson-Crick base pairs correlate with the lowered fidelity of replication. Interstrand hydrogen bonds appear to play a larger role in dNTP selectivity. The mechanism by which purine-purine mispairs are formed and extended was examined with Solfolobus solfataricus DNA polymerase IV, a member of the RAD30A subfamily of the Y-family polymerases, as is pol eta. The structures of the purine-purine mispairs were examined by comparing the kinetics of mispair formation with adenine versus 1-deaza- and 7-deazaadenine and guanine versus 7-deazaguanine at four positions in the DNA, the incoming dNTP, the template base, and both positions of the terminal base pair. The time course of insertion of a single dNTP was examined with a polymerase concentration of 50 nM and a DNA concentration of 25 nM with various concentrations of dNTP. The time courses were fitted to a first-order equation, and the first-order rate constants were plotted against the dNTP concentration to produce k pol and K d (dNTP) values. A decrease in k pol/ K d (dNTP) associated with the deazapurine substitution would indicate that the position is involved in a crucial hydrogen bond. During correct base pair formation, the adenine to 1-deazaadenine substitution in both the incoming dNTP and template base resulted in a >1000-fold decrease in k pol/ K d (dNTP), indicating that interstrand hydrogen bonds are important in correcting base pair formation. During formation of purine-purine mispairs, the k pol/ K d (dNTP) values for the insertion of dATP and dGTP opposite 7-deazaadenine and 7-deazaguanine were decreased >10-fold with respect to those of the unmodified nucleotides. In addition, the rate of incorporation of 1-deaza-dATP opposite guanine was decreased 5-fold. These results suggest that during mispair formation the newly forming base pair is in a Hoogsteen geometry with the incoming dNTP in the anti conformation and the template base in the syn conformation. These results indicate that Dpo4 holds the incoming dNTP in the normal anti conformation while allowing the template nucleotide to change conformations to allow reaction to occur. This result may be functionally relevant in the replication of damaged DNA in that the polymerase may allow the template to adopt multiple configurations.\nProject description:Base extrusion is a major structural feature at the junction between B- and Z-DNA (the B-Z junction) where a base pair is broken, and the two bases are extruded from the double helix. Despite the demonstration of base extrusion at the B-Z junction, it is not clear whether a similar base extrusion occurs at other types of junctions involving the left-handed Z conformation. Here, we investigate structural changes of bases at three Z-form junctions: DNA B-Z and Z-Z and RNA A-Z junctions. By monitoring fluorescently labeled duplex nucleic acids using 2-aminopurines at various positions relative to the junction point, we show that base extrusion occurs not only at the DNA B-Z junction, but also at the RNA A-Z and DNA Z-Z junctions. Our data suggest that base extrusion is a general feature of Z-form nucleic-acid junctions.\nProject description:Covalently interstrand cross-linked DNA is an interesting tool to study DNA binding proteins that locally open up the DNA duplex by flipping single bases out of the DNA helix or melting whole stretches of base pairs to perform their function. The ideal DNA cross-link to study protein-DNA interactions should be specific and easy to synthesize, be stable during protein binding experiments, have a short covalent linker to avoid steric hindrance of protein binding, and should be available as a mimic for both A/T and G/C base pairs to cover all possible binding specificities. Several covalent interstrand cross-links have been described in the literature, but most of them fall short of at least one of the above criteria. We developed an efficient method to site-specifically and reversibly cross-link thionucleoside base pairs in synthetic duplex oligodeoxynucleotides by bisalkylation with 1,2-diiodoethane resulting in an ethylene-bridged base pair. Both linked A/T and G/C base pair analogs can conveniently be prepared which allows studying any base pair-opening enzyme regardless of its sequence specificity. The cross-link is stable in the absence of reducing agents but the linker can be quickly and tracelessly removed by the addition of thiol reagents like dithiothreitol. This property makes the cross-linking reaction fully reversible and allows for a switching of the linked base pair from locked to unlocked during biochemical experiments. Using the DNA methyltransferase from Thermus aquaticus (M.TaqI) as example, we demonstrate that the presented cross-linked DNA with an ethylene-linked A/T base pair analog at the target position is a useful tool to determine the base-flipping equilibrium constant of a base-flipping enzyme which lies mostly on the extrahelical side for M.TaqI.", "label": "Yes"}
{"text": "Comprehensive DescriptionRead full entry\nBiologyA relatively rare species (Ref. 9710) found in coastal areas near reefs (Ref. 30573). Juveniles in shallow weedy areas. Omnivorous (Ref. 2799). Good to eat.\nThis taxon hasn't been featured in any communities yet.\nEOL content is automatically assembled from many different content providers. As a result, from time to time you may find pages on EOL that are confusing.\nTo request an improvement, please leave a comment on the page. Thank you!", "label": "Yes"}
{"text": "‘The neuroimaging results showed significant activity in two regions of the brain during the encoding of impression-relevant information. The first, the amygdala, is a small structure in the medial temporal lobe that previously has been linked to emotional learning about inanimate objects, as well as social evaluations based on trust or race group. The second, the posterior cingulate cortex (PCC), has been linked to economic decision-making and assigning subjective value to rewards. In the Nature Neuroscience study, these parts of the brain, which are implicated in value processing in a number of domains, showed increased activity when encoding information that was consistent with the impression.\n“Even when we only briefly encounter others, brain regions that are important in forming evaluations are engaged, resulting in a quick first impression,” commented NYU’s Phelps.\nNYU’s Schiller, the study’s lead author, concluded, “When encoding everyday social information during a social encounter, these regions sort information based on its personal and subjective significance, and summarize it into an ultimate score–a first impression.” ‘ via physorg.com.", "label": "Yes"}
{"text": "Baird Parker Agar is used for the isolation and differentiation of coagulase-positive staphylococci in food and pharmaceuticals according to the Baird Parker method.\nAs a nitrogen source for the organism, casein peptone and meat extract are added to the medium. Yeast extract provides nitrogen as well as other important nutrients like vitamin B12 complex. The medium contains lithium and tellurite, which inhibit most of the contaminating microflora, while glycine and pyruvate enhance Staphylococci growth. Staphylococci can reduce tellurite to telluride, which results in grey to black coloration of the colonies. With the addition of egg yolk, the medium becomes yellow, slightly opaque. A clear halo develops around colonies from coagulase positive Staphylococcus aureus, and upon further incubation may produce an opaque zone due to an egg yolk – lecithinase reaction (lypolytic activity). Grey-black colonies and a halo on this medium are presumed to be indicative of coagulase positive staphylococci, as a high correlation between coagulase test and lipophylitic activity was found. Staphylococcus aureus and some strains of Staphylococcus saprophyticus (Shaw et al.) may show both of these characteristics, but they are easily distinguished from each other by the different times at which the halo develops.\nBaird Parker Agar with Rabbit Plasma Fibrinogen can be used for the detection of coagulase activity. Coagulase positive organisms appear as grey to black colonies because of the tellurite reduction and as an opaque halo, due to the conversion by coagulase from fibrinogen to fibrin. Only plates with less then 100 characteristic colonies should be counted. Use of this medium eliminates the need for an additional coagulase test.\nTo continue reading please sign in or create an account.Don't Have An Account?", "label": "Yes"}
{"text": "In the study in part conducted by Asuka Orr the focus is on the crucial role of excipients in the formulation of biologics. Biologics, or protein-based therapeutics, are essential in modern medicine but face challenges such as phase separation and high viscosity due to protein-protein interactions (PPI). These issues can be mitigated by carefully selecting excipients, which enhance stability, bioavailability, and manufacturability of biologics.\nTraditionally, the selection of these excipients has been a trial-and-error process. However, the research introduces a novel computational approach, SILCS-Biologics, based on Site Identification by Ligand Competitive Saturation (SILCS) technology. This method allows for a more systematic and precise selection of excipients by predicting how various molecules interact with proteins in biologic formulations.\nThe SILCS-Biologics process involves immersing the target protein in a simulated water box containing potential excipients. Through advanced computational simulations, including Grand Canonical Monte Carlo (GCMC) and Molecular Dynamics (MD) simulations, the system identifies “FragMaps”. These FragMaps, categorized into different types like apolar, donor, and acceptor maps, visualize the free energy landscape across the protein surface, revealing hotspots where excipients are likely to bind.\nThis method not only predicts the binding sites for excipients but also provides insights into the mechanisms underlying protein stability. For example, the research demonstrates how the number of predicted binding sites correlates with the protein’s stability, thus guiding the selection of the most stabilizing excipients.\nBy employing SILCS-Biologics, the research signifies a leap forward in biologics formulation, offering a way to predictably enhance protein therapeutics. This approach promises to reduce the time and cost associated with developing more effective and stable biologic medicines, making this an essential read for professionals in pharmaceutical sciences and drug development.", "label": "Yes"}
{"text": "Combinatorial RNA interference as a gene therapy strategy for HIV-1 infection\nRetrovirology volume 10, Article number: P85 (2013)\nRNA interference (RNAi) is a mechanism of gene-suppression with potential gene therapy applications against chronic viral diseases. Combinatorial RNAi approaches are required to account for viral variability in treating HIV-1 infection, as single short hairpin RNAs (shRNAs) are rapidly rendered ineffective by resistant strains. Although promising, these approaches need to be optimized in terms of target selection, hairpin design and promoter choice in order to provide a highly effective anti-HIV-1 therapeutic strategy.\nMaterials and methods\nValidated small interfering RNAs (siRNAs) with targets within cellular CCR5 gene and HIV-1 tat/rev and vif sequences were inserted into a lentiviral vector under the control of either the U6, the 7SK or the H1 human polymerase III promoters, alone or in different combinations. Alternatively, the siRNAs were simultaneously expressed as an extended shRNA (e-shRNA) under the control of each selected promoter. Silencing efficiencies of the different vectors were compared by means of the luciferase knockdown assay. siRNAs antiviral activity and cytotoxicity were assessed both in cell lines and in human primary cells, including macrophages and CD4+ T lymphocytes.\nExperiments performed on single shRNA-expressing vectors indicated a specific silencing activity of the selected sequences, with the siRNAs targeting the CCR5 and the tat/rev genes leading up to 90% reporter gene knockdown. Activities of the U6 and H1 promoters were similar and superior to that of the 7SK, irrespective of the expressed siRNA. Furthermore, siRNA-CCR5 induced a marked cell surface CCR5 downregulation in transduced primary macrophages. When different siRNA transcriptional units were combined within a single vector, the silencing activity of each siRNA was not affected by its relative position in transfection experiments. On the other hand, differences were observed in transduced cells challenged with wild type HIV-1. As an alternative combinatorial approach, we designed an extended short hairpin RNA giving rise to three different siRNAs targeting CCR5, tat/rev and vif, under the control of either the U6, the 7SK or the H1 promoter. The obtained results showed that the silencing activity is strictly dependent on the used promoter, with the H1 being the most active, both in terms of target gene knockdown and inhibition of viral replication. In addition, the biosafety of human cell lines and primary cells expressing multiple siRNAs was evaluated and transduction at high multiplicity of infection turned out to affect endogenous microRNA processing.\nThis study confirms that combinatorial RNAi is a feasible approach to counteract HIV-1 replication, highlighting some important strengths and pitfalls of different platforms used for multiple siRNAs delivery. The data provide valuable insights for the design and application of reliable combinatorial RNAi that, once shown to be safe and effective in vivo, may be next in line for clinical testing.\nAbout this article\nCite this article\nSpanevello, F., Calistri, A., Del Vecchio, C. et al. Combinatorial RNA interference as a gene therapy strategy for HIV-1 infection. Retrovirology 10 (Suppl 1), P85 (2013). https://doi.org/10.1186/1742-4690-10-S1-P85", "label": "Yes"}
{"text": "Hospira, Inc. presented two studies supporting biosimilar application for Epoetin Hospira in the US.\nHospira, a global leader in biosimilars and the world’s leading provider of injectable drugs and infusion technologies, presented two studies at the National Kidney Foundation (NKF) Spring Meeting.\nThe two presentations were “PK/PD Equivalence of Epoetin Hospira and Epogen Following Single Subcutaneous Doses to Healthy Subjects,” and “Epoetin Hospira and Epogen PK/PD Equivalence Following Multiple Subcutaneous Doses to Healthy Subjects.” Both studies support an evaluation of biosimilarity of its proposed biosimilar, Epoetin Hospira, with the US Food and Drug Administration (FDA) conditionally approved name of Retacrit, compared to the reference product, Amgen’s Epogen (epoetin alfa).\nIn the US, Epogen is approved to treat anemia caused by chronic kidney disease in patients on dialysis to reduce or avoid the need for red blood cell transfusions.\nBoth of the studies evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) equivalence of Epoetin Hospira compared to Amgen’s Epogen administered by subcutaneous injection in healthy volunteers. One study tested a single dose of 100 units/kg, and the other evaluated multiple doses of 100 units/kg administered three times per week for a total of four weeks. The studies included measuring the effect of well-established PD clinical markers of reticulocyte count and hemoglobin. These measures were chosen because they are directly reflective of the mechanism of action of epoetin alfa and are known to directly correlate with clinical effects.\n“Both studies are consistent with the assessment of biosimilarity between the reference product, Epogen, and the Hospira proposed biosimilar, Epoetin Hospira,” said Stan Bukofzer, MD, corporate vice president and chief medical officer, Hospira. “These studies contribute to the demonstration of biosimilarity and are an integral part of the overall biosimilar development program.”\nHospira, which has agreed to be bought by Pfizer for a value of $17 billion, said that it has already filed a Biologics License Application (BLA) for Epoetin Hospira to the US Food and Drug Administration (FDA), under the new approval pathway created by the Biologics Price Competition and Innovation Act (BPCIA).\nSource: Hospira, Inc.\nLast updated: 3/27/14; 2:25pm EST", "label": "Yes"}
{"text": "Common problems of sludge treatment- sludge bulking\nSource：Jiangsu Envset Time:23 October 2020\nWhen we use the sludge dehydrator for sludge treatment, we will encounter many problems. How should we deal with these problems? Next, we will introduce you to the solution when the sludge expands.\nWe can control sludge expansion by adjusting the process operation measures. Adjusting and operating process control measures are very effective for sludge expansion caused by improper process conditions.\n1.Add clay, hydrated lime, raw sludge or digested sludge at the water inlet of the aeration tank to improve the sedimentation and compactness of activated sludge;\n2.Keep the wastewater entering the aeration tank in a fresh state, such as taking pre-aeration measures to make the wastewater in an aerobic state;\n3.Strengthen the aeration intensity, increase the DO concentration of the mixed solution, and prevent the mixed solution from being hypoxic or anaerobic;\n4.Supply nutrients such as nitrogen and phosphorus to maintain the balance of nutrients such as C, N, P in the mixed solution;\n5.Increase the sludge return ratio and reduce the residence time of sludge in the secondary settling tank;\n6.Perform pre-aeration to remove acid gas or add alkali to adjust the wastewater to increase the pH value of the influent of the aeration tank;\n7.Play the role of the adjustment tank to ensure that the sludge load of the aeration tank is relatively stable;\n8.Control the inlet water temperature of the aeration tank;\nAdd a biological selector in front of the aeration tank (permanent measure). The aerobic biological selector is to perform regenerative aeration before the return sludge enters the aeration tank, reduce the content of viscous substances in the return sludge, make the microorganisms enter the endogenous respiration stage, and improve the ability of the bacteria micelles to take up organic matter and Competitiveness with filamentous microorganisms. In order to enhance the effect of the biological selector, a sufficient amount of nutrients such as nitrogen and phosphorus can be added in the aeration process to improve the activity of the sludge.\nJiangsu Envset provides customers with high-quality sludge dewatering machines. We are familiar with common problems encountered when dealing with sludge. If you have any questions about the solution to sludge bulking, please contact us.\nTag: sludge treatment common problems, sludge bulking, sludge expansion", "label": "Yes"}
{"text": "Broccoli has edible young flowering stems and leaves that can be eaten raw or cooked. The plant produces a central inflorescence, the broccoli head, which can sometimes be followed by smaller flowering shoots.\nPlease note that due to stock-take and a phenomenal start to the season, the MeadowSweet online shop will not fulfill orders for a few weeks (10 Nov - 20 Nov) . You can still catch me at the Orewa Farmers Market, or you are most welcome to send inquiries on plant availability.\nThank you !\nMinette - MeadowSweet Herbs Dismiss", "label": "Yes"}
{"text": "The complement system consists of 30 proteins that interact in a carefully regulated manner to destroy invading bacteria and prevent the deposition of immune complexes in normal tissue. This complex system can be activated by diverse mechanisms proceeding through distinct pathways, yet all converge on a final common pathway in which five proteins assemble into a multimolecular complex, the membrane attack complex (MAC). The MAC inserts into cell membranes to form a functional pore, resulting in ion flux and ultimately osmotic lysis. Immunohistochemical evidence of the MAC decorating neurons in cortical gray matter has been identified in multiple CNS diseases, yet the deleterious consequences, if any, of MAC deposition in the cortex of mammalian brain in vivo are unknown. Zhi-Qi Xiong et al. demonstrate that the sequential infusion of individual proteins of the membrane attack pathway (C5b6, C7, C8, and C9) into the hippocampus of awake, freely moving rats induced both behavioral and electrographic seizures as well as cytotoxicity. The onset of seizures occurred during or shortly after the infusion of C8/C9. Neither seizures nor cytotoxicity resulted from the simultaneous infusion of all five proteins premixed in vitro. The requirement for the sequential infusion of all five proteins together with the temporal relationship of seizure onset to infusions of C8/C9 implies that the MAC was formed in vivo and triggered both seizures and cytotoxicity. Deposition of the complement MAC in cortical gray matter may contribute to epileptic seizures and cell death in diverse diseases of the human brain.\nDue to the multiple functions of the MAC, it is no surprise that the membrane attack complex has been implicated in an impressive number of diseases, evident via its detection in diseased tissues or its elevated levels in the blood, and that so many different clinically relevant microorganism have adopted numerous different techniques to escape the destructive action of complement.\nDeficiencies of the membrane attack complex / MAC cascade predispose to meningococcal infections, indicating that its cytolytic properties are of particular importance in host defence against Neisseria, for which there appears to be no sufficient back-up. Neutrophils can only provide partial protection, although they can kill meningococci when incubated in terminal complement deficient serum, and this effect increases after vaccination so that this may represent an alternative treatment option in addition to, or instead of, vigilance and antibiotic prophylaxis.\nTypically, membrane attack complex / MAC deficient subjects present in adolescence or in young adulthood, and suffer from recurrent meningococcal infections with especially the rarer serogroups. By way of example, the index case of a report in this journal issue by Vazquez-Bermudez et al. was ascertained because of three meningococcal disease episodes in a 15-year-old-boy.\n1. Xiong, Z. Q., Qian, W., Suzuki, K., & McNamara, J. O. (2003). Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. The Journal of neuroscience, 23(3), 955-960. 2. Würzner, R. (2003). Deficiencies of the complement MAC II gene cluster (C6, C7, C9): is subtotal C6 deficiency of particular evolutionary benefit?. Clinical & Experimental Immunology, 133(2), 156-159.", "label": "Yes"}
{"text": "BackgroundAgouti and Extension loci control the relative amount of eumelanin and pheomelanin production in melanocytes that, in turn, affects pigmentation of skin and hair. The Extension locus encodes the melanocortin 1 receptor (MC1R) whose permanent activation, caused by functional mutations, results in black coat colour, whereas other inactivating mutations cause red coat colour in different mammals.ResultsThe whole coding region of the MC1R gene was sequenced in goats of six different breeds showing different coat colours (Girgentana, white cream with usually small red spots in the face; Maltese, white with black cheeks and ears; Derivata di Siria, solid red; Murciano-Granadina, solid black or solid brown; Camosciata delle Alpi, brown with black stripes; Saanen, white; F1 goats and the parental animals). Five single nucleotide polymorphisms (SNPs) were identified: one nonsense mutation (p.Q225X), three missense mutations (p.A81V, p.F250V, and p.C267W), and one silent mutation. The stop codon at position 225 should cause the production of a shorter MC1R protein whose functionality may be altered. These SNPs were investigated in a larger sample of animals belonging to the six breeds. The Girgentana breed was almost fixed for the p.225X allele. However, there was not complete association between the presence of red spots in the face and the presence of this allele in homozygous condition. The same allele was identified in the Derivata di Siria breed. However, its frequency was only 33%, despite the fact that these animals are completely red. The p.267W allele was present in all Murciano-Granadina black goats, whereas it was never identified in the brown ones. Moreover, the same substitution was present in almost all Maltese goats providing evidence of association between this mutation and black coat colour.ConclusionsAccording to the results obtained in the investigated goat breeds, MC1R mutations may determine eumelanic and pheomelanic phenotypes. However, they are probably not the only factors. In particular, the surprising not complete association of the nonsense mutation (p.Q225X) with red coat colour raises a few hypotheses on the determination of pheomelanic phenotypes in goats that should be further investigated.\n|Numero di pagine||12|\n|Stato di pubblicazione||Published - 2009|", "label": "Yes"}
{"text": "Glycemic Index (GI) and Glycemic Load (GL) are two important things to know about foods we’re consuming as they may play big roles in helping us reduce the risks of getting heart diseases and several types of cancer. Additionally, low GI diets can also be beneficial to prevent diabetes and obesity.\nFoods with low GI are usually ones high in dietary fiber. Fiber is important due to its ability to bind large amount of liquid in our digestive tract, making us feel fuller longer. Fiber also triggers the release of leptin, hormone responsible for satiety, and controls the release of ghrelin that causes hunger.\nBut what are glycemic index and glycemic load exactly?\nGlycemic index is a number used to show how fast the carbs we consume can be turned by the body into glucose that serves as one of our energy sources, and how fast it can increase our blood sugar levels. Glycemic index is divided into 3 categories, which are low (<55), medium (56-69), and high (>70). The higher the GI, the faster a food is turned into glucose and the faster it affects the blood sugar levels. This is why people with diabetes are ordered to avoid foods with high glycemic index.\nMeanwhile, glycemic load is the number used to accurately show how much carbs get absorbed by our body from all the foods we eat. In one serving of a food, a GL lower than 10 is said to be low, a GL between 11-19 is considered medium, and a GL greater than 20 is considered high. We calculate the GL of a particular food using this following formula:\nGlycemic load = (glycemic index x carbohydrate content per portion)/100\nBoth GI and GL are useful for us to determine which foods may be added to or should be removed from our diets. By knowing the GI, we can see how fast our blood sugar levels can be affected by a certain food. And by calculating the GL, we know how much carbs are absorbed by our body.\nHowever, foods with low glycemic index don’t always mean they can’t affect our blood sugar levels. When consumed excessively, low GI foods will still cause blood sugar spikes. For example, 25 grams of red beans contain 17 grams of carbohydrates, has glycemix index of 20, and a glycemic load of 3,4 which is categorized as low. But when we increase the consumption to 200 grams, the IG will remain the same while the BG will increase to 24, which is said to be high.\nAside from the amount, we should also watch the combination of foods that we consume. Tea and chocolate drink that originally have low IG may turn into high GI beverages if we add sugar to increase the sweetness and enhance the taste. To keep the GI low, and keep the good flavor at the same time, we can use alternative products that we know have low glycemic index and are widely available on the market. Like FiberCreme, high-fiber multi-purpose creamer that we can find easily at stores near us, has glycemic index of 51 which is pretty low, and allows us to conveniently increase our fiber intake. To add sweetness, we can replace our regular sugar with low-calorie sweetener like stevia or monk fruit extract powder.\nFoster-Powell, K & Miller, J.B., 1995. International table of Glycemic Index. Am. J. Clin. Nutr. 62: 871S-893S.\nMarsono, Y., Wiyono, P., dan Zuheid Noor 2002. Index Glisemik kacang-kacangan. Jurnal Teknologi & Industri Pangan XIII (3): 211-216.\nTruswell, A.S. (1992) Glycaemic index of foods. Eur. J. Clin. Nutr. 46 (Suppl;. 2): S91-S101.", "label": "Yes"}
{"text": "Diabetes is a condition that affects how your body uses sugar for energy. It can cause serious complications, such as damage to your eyes, kidneys, nerves, and heart. The most common type of diabetes is type 2 diabetes, which occurs when your body becomes resistant to insulin, a hormone that helps sugar move from your blood into your cells. Type 2 diabetes can be prevented or delayed by making some lifestyle changes.\nHere are some tips on how not to get diabetes in future:\nMaintain a healthy weight. Being overweight or obese can increase your risk of diabetes, as excess fat can make your cells more resistant to insulin. Losing even a small amount of weight can improve your blood sugar control and lower your risk of diabetes. Aim for a body mass index (BMI) between 18 and 23, which is considered a healthy range.\nBe physically active. Exercise can help you burn calories, lose weight, lower your blood pressure and cholesterol levels, and improve your insulin sensitivity. It can also reduce your stress and boost your mood. Try to get at least 150 minutes of moderate-intensity physical activity per week, such as brisk walking, cycling, swimming, or dancing. You can also do some strength training exercises twice a week to build muscle and bone mass. Muscle tissue uses more glucose than fat tissue, so having more muscle can help lower your blood sugar levels.\nEat a balanced diet. Choose foods that are low in added sugars and refined carbohydrates, such as white rice, soda, candy, white bread, and pasta. These foods can spike your blood sugar and insulin levels, which can increase your risk of diabetes. Instead, opt for foods that are high in fiber, such as non-starchy vegetables, whole fruits, brown rice, and millets. Fiber helps slow down the absorption of sugar and keep your blood sugar stable. Also, include lean proteins, such as fish, eggs, chicken, and beans, and healthy fats, such as sesame oil, almonds, nuts, and seeds. These foods can help you feel full and satisfied without raising your blood sugar too much.\nQuit smoking. Smoking can damage your blood vessels and increase your risk of heart disease and stroke. It can also make your cells more resistant to insulin, which can lead to higher blood sugar levels. If you smoke, talk to your doctor about ways to quit. There are many options available, such as nicotine patches, gums, lozenges, inhalers, or medications. You can also join a support group or use online resources to help you quit.\nLimit alcohol intake. Alcohol can interfere with your blood sugar control and increase your risk of liver problems. It can also add extra calories and carbs to your diet, which can lead to weight gain. If you drink alcohol, do so in moderation and only with food. The recommended limit is one drink per day for women and two drinks per day for men.\nGet enough sleep. Lack of sleep can affect your hormones and metabolism, which can increase your appetite and cravings for sugary and fatty foods. It can also impair your insulin sensitivity and raise your cortisol levels, which can lead to higher blood sugar levels. Aim for at least seven hours of quality sleep per night. To improve your sleep hygiene, avoid caffeine and alcohol before bedtime, keep your bedroom dark and cool, turn off electronic devices at least an hour before bed, and stick to a regular sleep schedule.\nBy following these tips, you can lower your risk of developing diabetes and improve your overall health and well-being.\nDr. Karuturi Subrahmanyam, MD, FRCP (London), FACP (USA)\nInternal Medicine Specialist\nPhone : 85000 23456", "label": "Yes"}
{"text": "Our wild plants and flowers support all other wildlife, and as they are disappearing from our countryside, so are the birds and pollinators and other creatures that depend upon them.\nMany of us are keen to restore meadows, but Plantlife, the conservation charity, cautions against immediately reaching for the seed packet or seed bomb. The challenge is to conserve species while maintaining their essential 'wildness’.\nRestoring a meadow can take years, and you will need to take a hay crop in the late summer and ideally have livestock grazing in the autumn and over winter. But if you want to create a wildflower meadow in your garden, you just need an open, sunny space.\nIf you have an existing lawn, this could be a good starting point. Have a close look at it – it may already be home to wild flowers that mowing has prevented from flowering. The easiest thing to do is to allow the area you have allocated to grow one summer and see what comes up.\nIf you discover some attractive species that you would like to keep, simply weed out the more aggressive perennial weeds, such as nettles, and add wildflower plugs or seed.\nSTARTING FROM SCRATCH\n1 Remove the topsoil\nAn ideal time to do this is in July. Wild flowers thrive on nutrient-poor soil, so remove your turf and five centimetres of topsoil. You will need a strong spade and lots of energy, but it is worth it. Not only will this reduce nutrient levels, it is a good opportunity to get rid of weed roots. Once you have removed the topsoil, rake over the ground until you have a fine tilth.\n2 Remove the competition\nLeave the area for three to four weeks. It is likely that a spread of garden “weeds” may appear, so to ensure the wildflower seed will have a good start, weeding may be needed.\n3 Sowing the seed\nDo this towards the end of August. You only need one or two teaspoonfuls of seed per square metre, which should be sown on a day with no wind. Buy from a local supplier that provides seed from native British plants, as this will ensure that your flowers will grow happily and be suitable for local wildlife.\n4 Adding annuals\nCornfield flower seeds, such as poppies and cornflowers, will give you brilliant colour in the first year while the perennial meadow plants are getting established. They can also help to smother any unwanted “weeds”. Make sure you have some Yellow Rattle seed (see varieties, right), a pretty wild flower in its own right, as this semi-parasitic plant will limit the growth of competing grasses.\n5 Mowing is the key\nMow your meadow area at the end of winter to remove any old growth before spring. Then leave it untouched through spring and summer, to allow your wild flowers to grow to their full height. When the flowers are no longer looking their best and have set seed in late summer, give it a thorough mow. Remove the cuttings, otherwise you may be adding unwanted nutrients.\nFROM LAWN TO MEADOW\n1 Good lawn, bad lawn\nThe older and “weedier” your lawn, the better. If your lawn is like a bowling green, with fertile soil and no weeds, try to lower the nutrients in the soil by mowing regularly and removing the cuttings. It will take a year or two to get it down to the right nutrient level for wild flowers to thrive.\n2 Adding wild flowers\nStep 1 will create the right habitat for your plants. You can then add a selection of pot-grown wild flowers or seed. If you prefer seed, cut your lawn very short in the autumn and scarify it with a rake, creating patches of bare soil onto which you can scatter your seed. However, a more successful way is to grow your plants from seed in pots. Sow the seed in autumn and leave the pots outside over winter, as many wild flowers need a cold spell before they can germinate.\nTransplant your seedlings into individual pots when they have three or four leaves and concentrate the growth on getting healthy roots by cutting off any flower stems. You can then plant them out into your lawn in the spring.\n3 Keep up the mowing\nSee step 5, above\nFor more information: Plant Life", "label": "Yes"}
{"text": "Some genetic diseases are caused by a single fault in a 3 billion letter, DNA sequence. With more of our genetic sequence now understood, should we be editing those genes that don’t work properly, or even using this knowledge to eradicate pest populations? Gene editing tools such as CRISPR hold potential to do these things but, what is it and should we be getting excited just yet?\nCRISPR (pronounced ‘crisper’) stands for: Clustered Regularly Interspaced Short Palindromic Repeats. Hold on. This is a controversial gene editing tool and was unveiled in 2013, and posed the ability to eradicate diseases such as Huntington’s and Cystic Fibrosis, where the genetic problem had been identified. It also held the potential for ‘designer babies’, providing the opportunity for parents to choose more beneficial or wanted genes for their offspring. This is mainly why the general public objected to it. Many researchers however, were looking at CRISPR’s potential to remove faulty genes and even it’s application in pest control. So how does it work?\nA gene editing tool provides the ability to edit an organism’s DNA. DNA is made up of bases (A,T,C,G), and a group of bases make a gene. One gene can be made from anywhere between 100 – 2 million bases. The really hard bit is knowing what part of the sequence of bases causes the fault. Once this is discovered, a gene editing tool can remove, alter or add to the sequence of bases, correcting the problem. CRISPR uses an enzyme (i.e. nature’s catalysts) called Cas9 to target and chop up the DNA sequence where the fault lies. Chopping the sequence will ‘turn off’ the gene and stop the expression which that particular gene codes for. You can also use this method to add in more bases where they are missing and causing disease as a result. Once the change has been made, in theory, this change will be passed to subsequent cells when they divide and grow. What are some applications?\nThe obvious target would be diseases caused by genetic mutations or lack required genes. One such target could be cancer. At the start of this year (2018), CancerResearchUK published a blog post about the use of CRISPR against cancer cells. Not all cancers are caused by a genetic fault but some are and as a result, are a target for CRISPR research. If it were known which genes caused cancer directly, people could be tested in early life and have this detrimental gene removed. In theory. Tests have been conducted using CRISPR on embryos to successfully remove heart disease causing genes, and make them resistant to HIV. (It should be noted that these embryos were never implanted into a woman, and were not kept for more than 14 days). CRISPR tests on embryos are granted for those which are not to be grown to full term, a HUGE change in ethical law would be required to test further into embryonic growth.\nA study was conducted for the first time in mammals to see if researchers could eliminate pests. CRISPR could be used to ensure certain detrimental genetic mutations are passed to offspring, meaning that after only 2 generations the species could be eradicated. An example of this use could be in the elimination of mosquitoes which carry malaria. The idea is not to introduce an entirely new gene but instead, to use those which naturally occur and cause eventual death or infertility. This technique has been tested on mice at the University of California, but the results were hit and miss, not providing a consistent result each time. Please note, the researchers did not give the mice detrimental genes, instead they gave them ones which would express only white fur, to determine if the method would work. The team found that only female mutated mice were able to pass on the new gene to the offspring, and even then it was only a 73% success rate.\nThe use of CRISPR has seemingly no known bounds. In 2014, CRISPR was used to cure a disease in an adult mammal. Since then, CRISPR has been used to modify genetic material in human embryos, eliminate HIV in mice, and even improve agriculture. However, there is still far to go. Last month, two studies were published in the journal NATURE Medicine, identifying problems with the CRISPR process. They had seen that cells edited with CRISPR were missing key anti-cancer mechanisms, obviously increasing the risk of cancer for those cells. Another paper in NATURE Biotechnology, highlighted issues still to overcome, mentioning that we do not yet know the full effects when we change DNA in gene editing. Preventing the removal of, or damage to ‘good’ DNA, is still to be completely investigated. Therefore, the technology holds potential to be amazing and change the lives of many people with genetic disorders. However, there is still far to go and MUCH more research required before CRISPR can be used as a genetic treatment strategy.", "label": "Yes"}
{"text": "Images and screenshots\nScreenshots and other example images:\nMDFF with symmetry restraints\n- Kwok-Yan Chan\n- Leonardo G. Trabuco\n- Eduard Schreiner\n- Klaus Schulten\n(hint: click '+' to add more items)\nFitted a homology model (based on the closed state structure) into the map provided (which is in open state) by the molecular dynamics flexible fitting method. Fittings were done in solvent and here we first let the water and ions equilibrate by constraining the protein, and next we let the side chains equilibrate as well and finally performed the fitting. Symmetry restraints were used to maintain the symmetry.\nChiral errors and cis-peptide bonds in the starting structure were corrected by 2 VMD plugins, Chirality and Cispeptide, and restraints were used to prevent such errors during the fitting.\nopen-fitted.pdb - Fitting without symmetry restraints\nopen-symmetry.pdb - Fitting with symmetry restraints\nSubmitted PDB Models:", "label": "Yes"}
{"text": "Sleep disorders in seniors are more than just a nuisance. The results of a recent study (published in the American Heart Association’s journal Stroke) show that a decrease in the amount or quality of sleep that a senior enjoys can dramatically increase their risk of hardening of the arteries in the brain, This, in turn, can lead to stroke.\nThe study examined the cases of over 300 patients who lived to the age of 90 and who had undergone at least a full week-long sleep study. When researchers correlated the data they found that individuals with poor sleep patterns (with or without a diagnosed sleep disorders in seniors studied) were much more likely to have suffered at least one stroke than those who enjoyed normal sleep patterns.\nIn fact, 61% of those with poor sleep patterns had moderate to severe damage to the blood vessels in the brain. That made the at risk group 21% more likely to have blood vessel damage than those who regularly slept through the night.\nSleep Disorders in Seniors Aren’t “Part of Getting Older”\nMany of us believe that as we age less sleep is normal. We’ve all heard stories from older individuals who say they only sleep a few hours per night and get by fine the next day. However, no matter what your aging loved one says, their body still needs as much sleep as it did when they were in their 20s.\nSleep allows the body to rest and reset. It’s during our sleeping hours when the majority of the healing process occurs and sleep is essential for both mental and physical health. People who suffer sleep deprivation are at much higher risk for:\nHigh Blood Pressure\nMemory and Cognitive Impairment\nObesity (and all the health issues associated with it)", "label": "Yes"}
{"text": "Research may show how poverty shapes the brain\nTheGlobeandMail.com – news/national\nPublished Saturday, Jan. 01, 2011. Anne Mcilroy\nStudying “orchid children” could also provide new insight into how poverty shapes the brain.\nPreliminary evidence suggests poor children may be more likely to be highly sensitive to their environments, but scientists don’t yet know why this may be the case.\nA possible answer is epigenetics, or the way the environment – everything from stress to smoking – can affect the activity of genes.\nThe genetic code itself is not altered by stress, but studies with laboratory animals have shown the activity of some genes can be affected. The result can be either an increase or decrease in the production of stress hormones or various neurotransmitters that play a key role in the brain.\nTom Boyce and his colleagues at the University of British Columbia are running a series of sophisticated tests to assess whether the stress of living in poverty alters the activity of genes involved in brain development and function.\n“We are looking at the DNA involved in neuroregulation, the development of the brain, the control of emotion and so on,” Dr. Boyce says.\n< http://www.theglobeandmail.com/news/national/research-may-show-how-poverty-shapes-the-brain/article1855099/ >\nTheGlobeandMail.com – news/national/parenting – How to raise an ‘orchid child’ to blossom\nPublished Friday, Dec. 31, 2010. Last updated Saturday, Jan. 01, 2011. Anne Mcilroy\nA brown van with a small laboratory in the back pulls up at Connie Low’s home in Vancouver and a research assistant welcomes the nine-year-old inside. Soon, she is playing a frustrating computer game while machines monitor changes in her heart rate and breathing and assess other signs of stress.\nInside the house, a second member of the research team interviews Connie’s father about his daughter’s health and major events in her life, as well as her temperament and behaviour. How does she react to change or conflict? Does she get upset when her clothes are wet or the bath water is too hot? Is she observant? Do the tags on her clothes bug her?\nThe questions and tests are designed to identify “orchid children,” the 15 to 20 per cent of youngsters who are highly sensitive to their environments and very reactive to stress. This makes them more vulnerable to health and behaviour problems if they live in stressful conditions, preliminary studies have found. But with careful attention and nurturing, they can thrive and excel.\nIt is a new theory, a revolution in thinking that recasts genetic vulnerabilities as potential strengths. The University of British Columbia’s Tom Boyce, Anthony Herdman and their colleagues want to learn what is different about the genes and brains of orchid children, as well as the factors in their lives that help them do well. Are mentors, for example, important? What about feeling like being part of a school community or playing a sport?\nOne day, the work could lead to new screening tools, programs or teaching approaches designed to spot orchid children and help them bloom.\nSo far, the scientists have assessed 200 eight- to 10-year-old volunteers from a wide range of socioeconomic backgrounds. They plan to do 200 more by the end of the school year.\nThey collect DNA samples and measure each child’s response to stress. Connie is asked to prepare and deliver a five-minute speech about herself, both good things and bad, and to imagine she is speaking to her class rather than to research assistants and technicians. The research assistant also asks her to count backwards, by 3, from 200.\n“There will be some who aren’t responsive at all, some who are exceedingly responsive and a whole bunch in the middle,” says Dr. Boyce, who is also part of B.C’s Child & Family Research Institute.\nThe exceedingly responsive ones are the orchid children.\nThe children are also asked to perform a number of tasks designed to allow researchers to learn about their brains. The video game, called flanker fish, is used to assess how well they can focus their attention. Some of the children, although not Connie, are asked to perform other tasks on the computer while a machine measures the electrical activity of their brains.\nDr. Boyce and his colleagues are focused on children, but American psychologist Elaine Aron studies adults who were very likely orchid children in their youth.\nShe started the work two decades ago when she asked for student volunteers who were introverted and easily overwhelmed by stimulation, like being in a noisy place.\nShe found these individuals, up 15 to 20 per cent of the population, had much in common: They startled easily, were sensitive to pain, deeply moved by art and sensitive to bright lights, strong smells and coarse fabrics.\nSince then, Dr. Aron, who works at Stony Brook University in New York, has written a number of books about highly sensitive people.\nShe now calls the trait sensory-processing sensitivity and says something similar is found in other animals, including fruit flies, dogs, cats and horses. Individuals with it are more likely to watch and observe a situation before plunging in.\n< http://www.theglobeandmail.com/news/national/how-to-raise-an-orchid-child-to-blossom/article1854895/ >", "label": "Yes"}
{"text": "- Which variation is subject to natural selection?\n- How do Diploidy and balancing selection preserve genetic variation?\n- What is the difference between balancing and stabilizing selection?\n- What are 3 types of natural selection?\n- What are the 4 types of selection?\n- Is balancing selection natural selection?\n- Does balancing selection maintain genetic variation?\n- What decreases genetic variation?\n- Does directional selection reduce genetic variation?\n- How does selection affect genetic variation?\n- What is an example of balancing selection?\n- What are the 3 types of genetic variation?\n- Does natural selection increase or decrease genetic variation?\n- What are examples of disruptive selection?\n- What is positive selection in genetics?\nWhich variation is subject to natural selection?\nFour conditions are needed for natural selection to occur: reproduction, heredity, variation in fitness or organisms, variation in individual characters among members of the population.\nIf they are met, natural selection automatically results..\nHow do Diploidy and balancing selection preserve genetic variation?\nHow does diploidy act to maintain genetic variation? In order to be subject to natural selection, an allele must have an expressed phenotype. In diploid (or polyploid) species, recessive alleles can be maintained, even if they are deleterious, because the phenotype is not expressed in heterozygotes.\nWhat is the difference between balancing and stabilizing selection?\nThe key difference between stabilizing and balancing selection is that stabilizing selection is a type of natural selection which favours average phenotypes in a population while balancing selection is the maintenance of multiple alleles of a gene within a population in order to enhance genetic diversity.\nWhat are 3 types of natural selection?\nDirectional selection, stabilizing selection and disruptive selection are three types of natural selection.\nWhat are the 4 types of selection?\n19.3B: Stabilizing, Directional, and Diversifying SelectionStabilizing Selection.Directional Selection.Diversifying (or Disruptive) Selection.Comparing Types of Natural Selection.\nIs balancing selection natural selection?\nBalancing selection means that two alleles are maintained in the population because of natural selection. … This means that the fitness of an individual with two different versions of the allele is higher than the fitness of an individual with two copies of one of the alleles.\nDoes balancing selection maintain genetic variation?\nBalancing selection, on the other hand, brings the favored allele to an intermediate equilibrium, where it is maintained as a genetic polymorphism that potentially increases the variability in the genomic region nearby the selected locus.\nWhat decreases genetic variation?\nSources of Decreased Variation Mutation, recombination, and gene flow all act to increase the amount of variation in the genotypes of a given population. There are also forces at work that act to decrease this variability.\nDoes directional selection reduce genetic variation?\nDirectional selection has no effect on the amount of genetic variation in a population.\nHow does selection affect genetic variation?\nBecause natural selection acts directly only on phenotypes, more genetic variation within a population usually enables more phenotypic variation. Some new alleles increase an organism’s ability to survive and reproduce, which then ensures the survival of the allele in the population.\nWhat is an example of balancing selection?\nA well-studied case is that of sickle cell anemia in humans, a hereditary disease that damages red blood cells. … This is an example of balancing selection between the fierce selection against homozygous sickle-cell sufferers, and the selection against the standard HgbA homozygotes by malaria.\nWhat are the 3 types of genetic variation?\nFor a given population, there are three sources of variation: mutation, recombination, and immigration of genes.\nDoes natural selection increase or decrease genetic variation?\nNatural selection can decrease the genetic variation in populations of organisms by selecting for or against a specific gene or gene combination (leading to directional selection). … Selection can also prevent speciation by homogenizing the population genetic structure across all locations.\nWhat are examples of disruptive selection?\nDisruptive Selection Examples: ColorPeppered moths: One of the most studied examples of disruptive selection is the case of London’s peppered moths. … Oysters: Light- and dark-colored oysters could also have a camouflage advantage as opposed to their medium-colored relatives.More items…•\nWhat is positive selection in genetics?\nPositive selection is the process by which new advantageous genetic variants sweep a population. Though positive selection, also known as Darwinian selection, is the main mechanism that Darwin envisioned as giving rise to evolution, specific molecular genetic examples are very difficult to detect.", "label": "Yes"}
{"text": "Programmed death-1 (PD-1) was proven to deliver an inhibitory sign following binding to its ligands PD-L1 (B7-H1) or PD-L2 (B7-DC). cells and PD-L2-expressing Compact disc14+B monocytes. In chosen SLE sufferers and normal topics useful research of PD-1/ PD-1 ligands pathway in the creation of cytokines by activated PBMC was analyzed. Blockages of PD-1 or PD-1 ligands significantly increased the creation of IL-2 IFN-and IL-10 the amplitude Rabbit Polyclonal to Cyclin D3 (phospho-Thr283). of boost roughly ranged in one to 3 x. There have been no significant distinctions of the improving results on cytokine creation by blockage of PD-1/PDL pathway between SLE sufferers and normal topics. The study signifies that we now have no intrinsically faulty appearance and function of PD-1 and PD-1 ligands on PBMC in sufferers with SLE. 1 Launch Programmed loss of life-1 (PD-1) is certainly a novel person in CD28 family members. PD-1 was proven to deliver a poor indication after binding to either of its two ligands PD-L1 (B7-H1) or PD-L2 (B7-DC) in immune system responses [1-4]. On the other hand PD-1 and its own ligands have already been reported to try out an important function in the etiopathogenesis of murine autoimmune illnesses. Spontaneous autoimmune illnesses including lupus-like glomerulonephritis joint disease and fatal autoimmune dilated cardiomyopathy created in PD-1 deficient mice of different genetic backgrounds [5-7]. In addition blockade of PD-1/PD-L pathway could exaggerate or accelerate the development of autoimmune diseases such as diabetes in prediabetic NOD mice and experimental autoimmune encephalitis [8 9 Recently up-regulated manifestation of PD-1 molecule and/or its ligands was shown in human diseases including rheumatoid arthritis (RA) and inflammatory colitis indicating that PD-1 and PD-1 ligands were actively participating in the pathogenetic process in human being autoimmune diseases [10 11 Systemic lupus erythematosus (SLE) is definitely a prototype of human being systemic autoimmune disease characterized by dysregulated activation of both T and B lymphocytes and development of many autoantibodies. Accordingly PD-1 and PD-1 ligands may play a critical part in the pathogenesis of SLE. The present study thus aimed to investigate the manifestation and function of PD-1 and its two Talarozole ligands on peripheral mononuclear cells (PBMCs) in individuals with SLE. 2 Individuals and Methods 2.1 Individuals Twenty-eight individuals Talarozole who fulfilled at least 4 criteria for the analysis of SLE collection from the American College of Rheumatology  were enrolled in the study. They include 26 females and 2 males. All enrolled individuals were not taking corticosteroid and immunosuppressant providers for more than 4 weeks prior to the study. 26 young healthy females were utilized being a control group. Their peripheral blood was drawn and PBMC were isolated for flowcytometric analysis and in vitro culture immediately. 2.2 Measurement of PD-1 and PD-1 Ligands Appearance by Flowcytometry Flowcytometry with dual staining was performed using fluorescece-conjugatd MAbs including FITC-conjugated anti-CD3 anti-CD19 and anti-CD14 (BD Biosciences Sna Diego Talarozole CA USA) and PE-conjugated anti-PD-1 anti-PDL1 and anti-PDL2 (MIH clones e Bioscience Sna Diego CA USA). Quickly PBMC were ready from clean heparinized bloodstream using Ficoll-Hypaque thickness gradient parting and altered to 5 × 106 cells/mL. 2 hundred microliters of cell suspension system had been incubated with 20 < concurrently .001) and PD-1-expressing Compact disc19+B cells (5.11 ± 3.91% versus 2.14 ± 1.67% < .005). Relating to PD-1 ligands SLE sufferers had even more PD-L1-expressing Compact disc19+B cells (20.59 ± 10.24% versus 13.21 ± 1.67% < .005) and PD-L2-expressing Compact disc14+monocytes (84.78 ± 12.82% versus 72.12 ± 26.92% < .005) than normal controls. Despite somewhat elevated frequencies of PD-1 and PD-1 ligands appearance in a few cell populations from SLE sufferers the indicate fluorescence intensities of PD-1 and PD-1 ligands appearance over the positive cells weren't considerably different between sufferers with SLE and regular controls (data not really shown). The full total result shows that the expression of PD-1/PD-1 ligands had not been impaired in human SLE. 3.2 Ramifications of Blocking PD-1/PD-1 Ligands Pathway on Cytokines Creation by Stimulated PBMC In Vitro Cytokines are believed to play a significant function in the pathogenesis of SLE. We hence made to investigate the useful ramifications of preventing PD-1 or PD-1 ligands over the creation of varied cytokines made by in vitro cultured PBMC. The cytokines analyzed in the analysis included Th1-produced cytokines (IL-2 and IFN-production was more Talarozole powerful in SLE. The differences didn't Nevertheless.", "label": "Yes"}
{"text": "Purpose The goal of this study was to judge the result of aldose reductase (AR) inhibition on Posterior capsular opacification (PCO) using pig eye capsular bag super model tiffany livingston. of pig eyes capsular luggage, residual cells on both anterior and posterior capsule demonstrated vigorous development. Treatment with AR inhibitors considerably prevented the zoom lens epithelial cell development in capsular luggage and appearance of -SMA, -crystallin and ICAM-1. HLEC demonstrated a dose-dependent response to b-FGF, proliferation at lower Oxymatrine (Matrine N-oxide) ( 20 ng/ml) and differentiation/transdifferentiation at higher ( 50 ng/ml) concentrations. Inhibition of AR also avoided the b-FGF -induced activation of ERK1/2, JNK and NF-B in HLEC. Conclusions Our outcomes claim that AR is necessary for zoom lens epithelial cell development and differentiation/transdifferentiation in the capsular luggage indicating that inhibition of AR is actually a potential healing target in preventing PCO. aswell for 10 min at 4C. Aliquots from the lysates filled with equal quantity of proteins (40 g) had been separated on 10% SDS-polyacrylamide gels and used in polyvinylidene difluoride membranes (Immobilon; Millipore, Bedford, MA). The membranes had been after that incubated in preventing solution filled with 5% wt/vol dried out fat-free dairy and 0.1% vol/vol Tween-20 in tris-buffered saline. Subsequently, the membranes had been incubated with antibodies against CSMA, -crystallin, ICAM-1, phospho-p38, phospho-ERK1/2, phospho-SAPK/JNK, and total-p38, -ERK1/2 and CSAPK/JNK. The membranes had been cleaned and probed using the particular HRP- conjugated supplementary antibodies (SouthernBiotech, Birmingham, AL) and visualized by chemiluminescence (Pierce biotechnology, Rockford, IL). All blots had been probed with GAPDH or -actin being a launching control and proteins band intensities had been dependant on densitometric analysis through the use of Kodak Image place 2000R. Electrophoretic Flexibility Change Goat polyclonal to IgG (H+L) Assay (EMSA) The HLEC had been pretreated with or without AR inhibitors for 24 h in serum free of charge medium, accompanied by treatment with b-FGF (50 ng/ml) for extra 1 h. The nuclear ingredients were ready as defined previously.26 The Consensus oligonucleotides for NF-B transcription factors were 5-end labeled using T4 polynucleotide kinase. EMSA was performed as defined previous.26 The specificity from the assay was examined by competition with an excessive amount of unlabeled oligonucleotide and supershift assays with antibodies to p65. NF-B-Dependent Secretory Alkaline Phosphatase (SEAP) Appearance Assay To examine NF-B promoter activity in HLEC in response to b-FGF treatment, cells (1105 cells/well) had been plated in 24-well dish. The cells had been starved for 16 h in 0.5% FBS medium without or with AR inhibitors and transfected with pNF-B-SEAP2-construct and pTAL-SEAP control plasmid (Clontech, USA) using Lipofectamine plus (Invitrogen, Carlsbad, CA) transfection reagent following suppliers instructions. After 6 h of trasnfection, cells had been activated with b-FGF (50 ng/ml) for 48 h. The cell tradition media were gathered and centrifuged Oxymatrine (Matrine N-oxide) at 5000 rpm Oxymatrine (Matrine N-oxide) and supernatants had been kept at ?80C. The moderate was thawed and useful for chemiluminescent secretory alkaline phosphatase (SEAP) assay using Great EscAPeTM SEAP reporter assay program according to process essentially as referred to by the product manufacturer, (BD Biosciences, Palo Alto, CA) utilizing a 96-well chemiluminescence dish reader. All of the recommended controls by producers were found in the assay. RNA disturbance ablation of AR HLEC had been cultivated to 60% confluence in DMEM supplemented with 20% FBS in 6-well dish. The cells had been incubated with OptiMEM moderate comprising the AR-siRNA (AATCGGTGTCTCCAACTTCAA) or scrambled siRNA (AAAATCTCCCTAAAT CATACA; control) to your final focus of 100 nM as well as the RNAiFectTM transfection reagent (Qiagen) as referred to by us previous.38 Briefly, for every well, 2 g AR siRNA was diluted in serum-free moderate to give one last level of 100 l and incubated with 6 l RNAiFect? for 15 min at space temp. The transfection blend was put into the particular wells, each comprising 1900 l full moderate (20% fetal bovine serum), and incubated for 24 h. After 24 h, the moderate was changed with clean DMEM.", "label": "Yes"}
{"text": "CBD treats for dogs have gained popularity as pet owners seek natural remedies to improve their furry friends’ well-being. Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, cbd treats for dogs has shown promising benefits for various health issues in dogs, making it a popular choice for holistic pet care.\nOne of the primary reasons pet owners turn to cbd treats for dogs is to alleviate anxiety and stress in their dogs. Dogs, like humans, can experience anxiety due to various factors such as separation, loud noises, or changes in their environment. CBD interacts with the endocannabinoid system in dogs, helping to regulate mood and reduce stress levels. Many pet owners have reported positive results, with their dogs exhibiting calmer behavior after incorporating CBD treats into their routine.\nAnother significant application of CBD treats for dogs is in managing pain and inflammation. Aging dogs or those suffering from conditions like arthritis may experience discomfort and reduced mobility. CBD has anti-inflammatory properties that can help alleviate pain by targeting the source of inflammation. This makes it a natural alternative to traditional pain medications, which may have potential side effects.\nCBD treats may also have a positive impact on dogs with epilepsy or seizures. Some studies suggest that CBD can help reduce the frequency and severity of seizures in dogs with epilepsy. While more research is needed to fully understand the mechanisms behind this, anecdotal evidence from pet owners suggests that CBD treats can be a valuable addition to the treatment plan for dogs with seizure disorders.\nSkin conditions, such as allergies or dermatitis, are common in dogs and can cause discomfort and itching. CBD’s anti-inflammatory and immune-modulating properties may provide relief for dogs with skin issues. Pet owners have reported improvements in their dogs’ coat condition and a reduction in itching after incorporating CBD treats into their pets’ diet.\nIt’s crucial for pet owners to choose high-quality CBD treats specifically designed for dogs. These treats should be free from THC, the psychoactive compound found in cannabis, as it can be harmful to dogs. Additionally, proper dosing is essential, and consulting with a veterinarian before introducing CBD treats is advisable, especially if the dog is on other medications.\nCBD treats for dogs offer a natural and holistic approach to supporting their overall well-being. Whether managing anxiety, alleviating pain, or addressing specific health issues, many pet owners have found CBD treats to be a valuable addition to their dogs’ daily routine. As with any supplement, it’s essential to prioritize the health and safety of the furry companions by choosing reputable products and consulting with a veterinarian when in doubt.", "label": "Yes"}
{"text": "Age-defying serum based on nanotechnology. Hyalogy Alpha serum is effective for reviving, firming and 'lifting' the skin showing signs of ageing, loss of firmness and elasticity.\nThe unique formula of biomimetic peptides has a powerful stimulation effect on fibroblasts, restores the structure of the dermis and epidermal-dermal conjunction. Hyalogy A noticeably reduces the depth of fine lines and wrinkles. Skin appears ultimately revived.\nHyalogy Alpha serum 30ml\nAcetyl decapeptide -3\nPalmitoyl tetrapeptide - 7\nPalmitoyl tripeptide -5\nPalmitoyl dipeptide - 5\nHydrolyzed keratin, collagen, elastin\nSaccharomyces lysate extract\nNano and low-molecular Hyaluronic acid\nEggshell membrane protein\nIonized minerals (Ca, Zn, Mg)\nSkin with lack of firmness and elasticity.\nFine lines and wrinkles.\nAge group: 35+ 40+ 50+ 60+ 70+", "label": "Yes"}
{"text": "High fructose corn syrup (HFCS) is corn syrup whose glucose has been converted to fructose. It is an artificial sugar made from corn syrup. Glucose is easily transported and utilized by every cell in your body. It’s also the predominant fuel source for high-intensity exercise and various processes. Your body metabolizes fructose differently than glucose, and consuming too much fructose can lead to health problems. It is a common sweetener in sodas and fruit-flavored drinks. As use of high-fructose corn syrup has increased, so have levels of obesity and related health problems.\nHigh-fructose corn syrup is a sugar-based sweetener, used in processed foods and drinks in the United States. Like regular sugar, it consists of the simple sugars glucose and fructose.\nIt’s important to note that the detrimental effects of fructose in added sugar, including HFCS, should not be equated with the fructose in fruit. The conversion produces sweetness of desired types. The material is used in many breads, cereal, sodas, yogurt, and breakfast bars. In contrast, the fructose from high fructose corn syrup or table sugar needs to be converted into glucose, glycogen (stored carbs), or fat by the liver before it can be used as fuel.\nTo create HFCS, manufacturers add enzymes to corn syrup that convert some of the glucose to fructose. HFCS is derived from corn starch. Fructose is the type of sugar present in fruit and is very sweet. When corn starch is broken down into individual glucose molecules, the end product is corn syrup, which is essentially 100% glucose. The amount of fructose in HFCS varies, but the most common varieties contain either 42% or 55%. HFCS is ‘high’ in fructose compared to the pure glucose that is in corn syrup. Research has consistently shown links between the consumption of HFCS and obesity, metabolic dysregulation, and similar health issues.\nHigh fructose corn syrup was first introduced during the late 1950s. The fructose in HFCS can cause health issues if eaten in excessive amounts. The material did not come to the United States until the late 1970s into the 1980s. It is a sweetener that manufacturers make from corn starch. As with other sugars, it can cause tooth decay, obesity, and metabolic syndrome when a person consumes it in large quantities.\nHigh fructose corn syrup has been linked to obesity, diabetes and certain other health matters. Like regular table sugar, HFCS is a rich source of fructose. In the past few decades, the intake of fructose and HFCS has increased significantly. It’s difficult to consume excessive amounts of fructose from whole fruits, which are healthy and safe in sensible amounts. Due to its fructose content, it has been heavily criticized for its potential negative health effects. Many people claim that it’s even more harmful than other sugar-based sweeteners.", "label": "Yes"}
{"text": "2012 Seven Things to tell your friends about GMO (Fact Sheet)\nIn the 1990s, GMOs took off in the US without public debate and today they’re in most processed foods — making Americans the world’s GMO guinea pigs. Now, peer-reviewed and other authoritative studies reveal that: 1. GMOs HAVE NEVER UNDERGONE STANDARD TESTING OR REGULATION FOR HUMAN SAFETY. And now that they’re in 70 percent of processed foods it’s extremely difficult for scientists to isolate their health risks. 2. BUT WE KNOW THAT GMOs HAVE PROVEN HARMFUL IN ANIMAL STUDIES. A 2009 review of 19 studies found mammals fed GM corn or soy developed “liver and kidney problems” that could mark the “onset of chronic diseases.” In a new 2-year study, rats fed GM corn developed 2-3 times more tumors and they appeared much earlier than those fed non-GM corn. Among scientists, both defenders and critics underscore that we need more long-term studies. 3. AND THE MOST WIDELY USED GMOs ARE PAIRED WITH AN HERBICIDE LINKED TO SERIOUS REPRODUCTIVE PROBLEMS AND DISEASE. GM crops – Roundup Ready soy & corn – are treated with the herbicide glyphosate. A physicians’ study found people exposed to glyphosate had increased risk of miscarriages, birth defects, cancer, and neurological problems in children. Neurologists report that herbicides, especially glyphosate, “have been recognized as the main environmental factor associated with ... Parkinson’s disease.” 4. THE CONSEQUENCES OF GMO TECHNOLOGY ARE UNPREDICTABLE. Inserting a single gene can result in multiple, unintended DNA changes and mutations. “Unintended effects are common in all cases where GE [genetic engineering] techniques are used,” warn scientists. One such environmental consequence—genetic contamination of other plants—is already documented. Note that unlike food, once released into the environment, seeds can’t be “recalled”! 5. GMO MAKERS INTIMIDATE AND SILENCE FARMERS AND SCIENTISTS. GMO corporations use patents and intellectual property rights to sue farmers, block research, and threaten investigators. “For a decade,” protested Scientific American editors in 2009, GMO companies “have explicitly forbidden the use of the seeds for any independent research” so “it is impossible to verify that genetically modified crops perform as advertised.” 6. GMOs UNDERMINE OUR FOOD SECURITY. Because three GMO companies – Monsanto, DuPont, and Syngenta – control 70% of the global seed market, GMOs reinforce monopoly power over our food. GMO seeds are costly and must be purchased every year, so they worsen farmers’ indebtedness, dependency, and vulnerability to hunger. 7. GMOs AREN’T NEEDED IN THE FIRST PLACE, SO WHY WOULD WE TAKE ON THESE RISKS AND HARMS? Studies show that safe, sustainable farming practices applied worldwide could increase our food supply as much as 50 percent. And keep in mind that the world’s already producing 2,800 calories for every person on earth every day — more than enough. And that’s just with what’s left over: Half the world’s grain goes not to people but to feed, fuel and other purposes. Plus, one-third of all food. So the urgent question isn’t about “more” anyway. It is, How can all of the world’s people gain the power to secure healthy food? And a good start is knowing what’s in our food.\n1. Source for GMOs in 70% processed foods: California Department of Food and Agriculture, “A Food Foresight Analysis of Agricultural Biotechnology: A Report to the Legislature,” Jan. 1, 2003. www.cdfa.ca.gov/files/pdf/ag_biotech_report_03.pdf. Source for safety testing: Freese, W. & Schubert, D., “Safety testing and regulation of genetically engineered foods,” Biotechnol Genet Eng Rev, 2004: 299-324. www.saveourseeds.org/downloads/schubert_safety_reg_us_11_2004.pdf. 2. Source for GM corn study: Séralini, G.-E., et al., “Long term toxicity of Roundup herbicide and a Roundup-tolerant genetically modified maize,” Food and Chemical Toxicity, http://dx.doi.org/10.1016/j.fct.2012.08.005. Source 19 GM corn and soy studies: Séralini G.-E. et al., “Genetically modified crops safety assessments: Present limits and possible improvements,” Environmental Sciences Europe, 2011; 23(10). www.enveurope.com/content/23/1/10 3. Sources for miscarriages, birth defects, cancer: Report from the 1st NATIONAL MEETING OF PHYSICIANS IN THE CROP-SPRAYED TOWNS, Faculty of Medical Sciences, National U. of Cordoba. Aug 2010, University Campus, Cordoba Coordinators: Dr. Medardo Ávila Vazquez, Prof. Dr. Carlos Nota. www.permaculturenews.org/files/INGLES-Report-from-the-1st-National-Meeti.... Source for link to Parkinson’s Disease: Gui, Y. et al., “Glyphosate induced cell death through apoptotic and autophagic mechanisms,” Neurotoxicol Teratol. March 27, 2012; 34: 344-349. http://www.sciencedirect.com/science/article/pii/S0892036212000438 4. Source for unpredictability: Wilson, A.K. et al., “Transformation-induced mutations in transgenic plants: Analysis and biosafety implications,” Biotechnol Genet Eng Rev, 2006; 23: 209–238. www.somloquesembrem.org/img_editor/file/Wilson%2006%20BGER.pdf. Source for 1st quote: Freese, W. & Schubert, D., “Safety Testing and Regulation of Genetically Engineered Foods,” Biotechnology and Genetic Engineering Reviews, Nov 2004; Vol. 21. www.intercept.co.uk/gb/not.asp?id=RS6HS3O6S6ROTD&rec=oui&pos=0&referer=%.... Source for genetic contamination: Quist, D. & Chapela, I., “Transgenic DNA introgressed into traditional maize landraces in Oaxaca, Mexico,” Nature, Nov 29, 2001; 414: 541-543. http://www.nature.com/nature/journal/v414/n6863/full/414541a.html. Source for 2nd quote: Cummings, C. H., “Trespass: Genetic Engineering as the Final Conquest,” WorldWatch Institute, World Watch Magazine, Jan/Feb 2005: 18(1), http://www.worldwatch.org/node/568 5. Waltz, E. “Under wraps – Are the crop industry’s strong-arm tactics and close-fisted attitude to sharing seeds holding back independent research and undermining public acceptance of transgenic crops?” Nat Biotechnol, Oct 2009; 27(10): 880–882. www.nature.com/nbt/journal/v27/n10/abs/nbt1009-880.html. See also: Center for Food Safety. “Monsanto vs. US farmers: Nov. 2007 Update.” Washington, DC & San Francisco, CA. Nov. 2007. www.centerforfoodsafety.org/pubs/Monsanto%20November%202007%20update.pdf. For Scientific American editors: The Editors, “Do Seed Companies Control GM Crop Research?” Scientific American, Aug 13, 2009. www.scientificamerican.com/article.cfm?id=do-seed-companies-control-gm-c.... 6. Source for Monsanto 90% statistic: Marie-Monique Robin, “The World According to Monsanto: pollution, corruption and the control of our food supply,” The New Press, 2010, http://thenewpress.com/index.php?option=com_title&task=view_title&metapr.... And: Center for Food Safety, “Monsanto vs. US Farmers,” 2005: www.centerforfoodsafety.org/pubs/CFSMOnsantovsFarmerReport1.13.05.pdf Source for GMO monopoly statistic: GRAIN, “Global agribusiness: two decades of plunder,” July 13, 2010. www.grain.org/article/entries/4055-global-agribusiness-two-decades-of-pl.... Source for GMO impacts on farmers: FAO, “Weighing the GMO arguments: against,” FAO Newsroom, 2003. www.fao.org/english/newsroom/focus/2003/gmo8.htm. 7. Source for producing plenty: Badgley, C. et al., “Organic Agriculture and the Global Food Supply,” Renewable Agriculture and Food Systems, 22 (2007): 86-108. http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid.... Source for calories: FAOSTAT, Food Balance Sheets, Commodity Balances, 2009, faostat.fao.org/site/368/DesktopDefault.aspx?PageID=368#ancor Grain statistic calculated from: FAO, “Crop Prospects and Food Situation,” Oct. 2007, No. 5, Table 2 ftp://ftp.fao.org/docrep/fao/010/ah873e/ah873e00.pdf Source for food wasted: FAO, “Global Food Losses and Food Waste,” Rome: 2011, http://www.fao.org/docrep/014/mb060e/mb060e00.pdf [verified 4/17/14]", "label": "Yes"}
{"text": "Antibody tests to determine if a person has had a past infection of COVID-19 may be wrong up to half of the time, according to the CDC.\n\"I don't think we should be making any decisions using those antibody tests,\" said Dr. Sanjay Gupta.\nDr. Gupta says a lot of the antibody tests initially put out were not good. The FDA has since put out a policy requiring antibody test makers to submit emergency authorization requests, along with proof the tests work.\n\"False positives is the worst kind of results because you think if I've got the antibodies, I'm good to go -- you're not and so the tests aren't good enough right now,\" said Dr. Gupta.\nThe CDC says health officials or healthcare providers using antibody tests need to use the most accurate tests they can find and might need to test people twice.\n\"Also we still don't know the exact meaning of what the antibodies are going to provide in terms of how long people would be protected as a result of these antibodies how strong these antibodies will be,\" explained Dr. Gupta. \"It's likely they'll have some protection but we just don't know the extent of it yet.\"", "label": "Yes"}
{"text": "The first divers visiting Alor have written enthusiastically about the dive sites being full of schools of fish and sharks (there is even dive site called Sharks Galore see No 12). Nowadays you come here more for the beautifully covered walls and the interesting critters you find in the muck here. In 2015 I spend 2 weeks in Alor and we didn’t see many sharks except while snorkelling in front of our resort in Kepa, but I took loads of photos of the smaller critters there, among them some nudibranch species I hadn’t seen in my over 20 years of diving except in books! So I think it is still well worth to come here, just enjoy the spectacular walls and the weird critters!\nAlor Island, situated in the east of Indonesia (Nusa Tenggara) has become more and more accessible with flights from Denpasar / Jakarta to Kupang and daily flight on to Alor. Alor can also be reached by ferries either from Kupang (Timor) or overland from Maumere (Flores) through Lembata and Pantar. There are 4 dive centers in Alor and Pantar and also liveaboards stopping in the area.\nBetween the islands of Alor and Pantar lies the strait of Pantar (Selat Pantar). Here the water coming from the Pacific in the north is flowing through this strait to the Indian Ocean in the south. This big “river” in the ocean is called the Indonesian Throughflow (see dive conditions in Komodo or southern Bali, where the situation is similiar) and the Pantar strait is one of the few gaps in the long chain of islands reaching from Sumatra to Timor where it can flow through, mostly from north to south. The smaller islands of Pura, Kepa, Ternate and Buaya lie smack in the middle of the strait and where the strait narrows the currents can be quite fierce. At some places the currents are so strong, that boats get turned sideways and have to really fight to reach places up current.\nWater temperatures are around 27 degrees, but especially in the south it can get quite cold – we had 23 degrees at some of the dive sites. Cold water is upwelling from the very deep parts north of Alor and then hitting the southern shores. This also means that sunfish (Mola mola) and Thresher sharks come up from the deep to get cleaned. Sometimes very strange animals appear from the depth (see Lophiodes fimbriatus (video), a deep sea anglerfish). The bay is somewhat protected, so there are often large pods of dolphins and whales travelling through.\nWant to know more about how to assess accurately the rate of current? Click here.\n1. Kal's Dream (Pulau Kepa) - 2. The Bullet - 3. Tri-Top - 4. Mucky Mosque - 5. Pertamina Pier - 6. Dive Logs - 7. The Mini Wall - 8. No Man's Land - 9. The Cathedral (Motolang) - 10. Hari Lalong - 11. School's Out - 12. Sharks Galore - 13. Clown Valley (Apuri) - 14. Malal - 15. Slab City - 16. The Boardroom (Tangaban) - 17. Smart's Lament (Abila Wall) - 18. Coconut Grove (Teluk Limraning) - 19. Sea Apple Slopes - 20. Bama - 21. Pan Abang - 22. The Arch - 23. Babylon - 24. Coral Cliffs - 25. The Edge (Umapura) - 26. Crocodile Rock - 27. Peter's Prize - 28. Half Moon Bay - 29. Cave Point - 30. Nite Delight - 31. The Patch - 32. Fault Line\nA) La P’tite Kepa Divers (www.alor-diving.com) based on Kepa Island close to Alor\nB) Alor Dive (www.alor-dive.com) based in Kalabahi\nC) Alami Alor Dive Resort (www.alamialor.com) based in the Bay of Kalabahi\nD) Eco Dive Resort Alor (www.alor-divers.com) based on northern Pantar\nDive Alor Dive (www.divealor.com) based in Kupang (Timor)\nSome of the dive operators are closed in winter. And - since internet connections are difficult fast answers to mails are not always possible....!\n1. Kal's Dream (Batu Kepa): You dive on two underwater pinnacles (top = 7m and 2m) lying northwest of Kepa island. The currents coming from the north hit these rocks smack on, so most of the time it is too wild to dive here. Sometimes the currents also shift and what was a nice dive turns into an up and down, left and right tugging experience!\nOn my first trip to Alor in 2002 with a liveaboard this dive site was supposed to be the ne plus ultra with large fish, sharks and rays. Actually at the start of our first dive it seemed like great things were to come - we saw a group of barracudas, then a whitetip shark and a large marble ray. When these animals disappeared, there was nothing more to report. Nearly no medium sized fish, just Anthias over corals and current. We waited and waited, but nothing large showed. On our second dive not even a single large fish showed up. The most adventurous thing was actually surfacing among the up and down currents where one of my dive buddies came up with 20 bars left, because he was swept down to a considerable depth before he was able to surface.\nComing back in 2015 I dived with Cedric from La P’tite Kepa. He knows the divesite inside out and he checked out the dive conditions on the site over several days. So when we actually dived there, the currents had calmed down for most of the dive, though they switched and picked up somewhat towards the end. We even managed to first dive around the deeper pinnacle and also follow part of the spur going out to a corner where there were lots of fish gathering and then leisurely swim over to the other pinnacle and finish our dive there. We saw a large dogtooth tuna, three large Napoleon wrasses, two of the fighting with each other, some trevallies and sweetlips. The pinnacles are nicely covered, though corals are low lying because they are exposed to the currents. Interesting were also some Coral Crouchers (Caracanthus maculatus) and several Yellow-spotted Scorpionfishes (Sebastapistes cyanostigma) packed tightly between the branches of an Acropora coral. Still a spectacular dive site, but only dive there, if the conditions are right!\nThis narrow and steep bay looks like a finger pointing to the east and it nearly separates Alor kechil (small Alor) from Alor besar (big Alor). The bay is quite long and deep with some pearl farms and fishing rafts close to the shore. The terrain is very rugged with Kalabahi situated where Alor kechil and Alor besar are joined together - the only flat area...\n4. Mucky Mosque dive sites: Along the northern coast of Kalabahi bay are several muck dive sites. These dive sites are also good for night dives. You find everything you want, from Rhinopias scorpionfishes to leaffishes, ghostpipefishes (Halimeda, Ornate and Robust) to frogfishes, seahorses and dragonets as well as crabs, shrimps and a lot of different nudibranchs. Often long ropes covered with hydroids and small corals come down from the shore – a good place to look for frogfishes perching there. On one of my dives a big black Giant frogfish was actually swimming away from one of these ropes and trying to perch on my (black) camera housing instead. When I moved away (I wanted to take photos of the frogfish swimming!) it decided on the next dark place which was one of my dive buddies. It made straight for him as if attacking him and ended up sitting on his chest, face to face with him! Probably thought he was a nice black sponge……\n5. Pertamina Pier and 6. Dive Logs: Further up towards Kalabahi close to the Pertamina Pier is another nice muck dive site – lots of sand but with many interesting animals living on it. I found a fingered dragonet, two Ambon scorpionfishes, juvenile batfishes and lots of squat lobsters, some on featherstars, some on sponges and a nice selection of slugs and nudis. My dive guide told me, you also find the Wonderpus (Wonderpus photogenicus) and Mimic Octopus (Thaumoctopus mimicus) here. On the other side of the bay (Dive Logs) there is an area with mangroves which is also very interesting for muck diving. Here you can find Randall's goby, the metallic goby, waspfishes and also Rhinopias and other interesting scorpionfishes.\n9. The Cathedral (Motolang): I really liked this dive site! Above water there is a steep rock wall descending into the sea, so underwater there are huge jumbled rocks and boulders and a steep wall covered with lots of hard and soft corals and sponges. We saw Barbiganti seahorses, a Potohi Seahorse (in the Halimeda algae), a bluering octopus and two different species of frogfish. There is a swim through with a cave at about 25 meters and we were lucky and found a huge tawny nurseshark (Nebrius ferrugineus) lying in the cave there.\n10. Hari Lalong: A really beautiful dive site with huge rocks lying side by side with many narrow spaces in between to swim through. There was a hidden comet fish, mandarin fishes and a large morey eel which was gaping at us. Good for a slow drift dive with a gentle slope at the end, covered with soft corals and plenty of small fish. You finish the dive leisurely following a small group of Barracudas in the shallow and taking a close look at the huge coral blocks covered with glassfishes.\n12. Sharks Galore: Our dive started in the dive site called Sharks Galore but the sharks must have all been on vacations because we didn't see a single one. The underwater landscape is quite nice and like in other dive sites along the eastern coast of Pura there were a lot of anemones. Coming out of the water our dive guide laughed and said he had just thought of a new name for this dive site - “Sharks No More”.\n13. Clown Valley (Apuri): This dive site is astonishing, because every surface is covered in sea anemones. Nearly all of the anemones I believe are Bulb-tentacle Sea Anemone (Entacmaea quadricolor) mostly with Clarks Anemonefishes (Amphiprion clarkii) and a few with Tomato Anemonefish (Amphiprion frenatus) in them. Considering how many anemones there are – I calculate there must be millions - there are only relatively few anemone fishes living in them. I often saw them flitting from one anemone to the next when I approached, so they seemed to change their host frequently. Apart from the anemones we saw also some sea apples (see Sea Apples Slope No 19) and – what a nice surprise – two yellow Miamira miamira nudibranchs in the shallow. While surfacing we also noticed bubbles coming out from the ground – a testimony to the volcanic nature of Pura Island.\n14. Malal: This is another dive site where the entire area is covered with thousands of anemones. Just for that it is well worth to go there, it is a sight seen only in very few places. The reason for this abundance of sea anemones is unclear. Apart from the anemones we were lucky to find a Wobbegon shark (Orectolobus leptolineatus), a smaller species than Wobbegon sharks in Papua and with only a few tassels.\nPura island is a small volcano cone island, the extinct volcano is 1015m high with a heavy forested crater. Pura being an extinct volcano there are several dive sites where there are air bubbles coming out from the ground, mostly in the shallow sandy areas.\n16. The Boardroom (Tangaban): A muck dive site with low coral cover on a slope. My dive guide found two pegasus sea moths, a pair of robust ghostpipefishes and a large Kentrodoris rubescens nudibranch which in my opinion looks just like a poodle without legs....!\n17. Smart’s Lament (Abila Wall): A nice wall with lots of small crannies, covered with soft corals, black coral bushes and hydroids. Halfway on the wall there is a huge Elephant Ear sponge, perhaps 3 meters wide, like a vertical barrier. Lots of yellow cup corals, so if there is some current it must look really beautiful with the tentacles out. During our dive the current picked up and we had schools of fusiliers and hunting jackfishes.\n18. Coconut Grove (Teluk Limraning): You descend on dark volcanic sand mixed with small coral boulders covered with soft corals and hydroids. Doesn’t look like much but to my amazement our dive guide Bram found three Weedy Scorpionfishes (Rhinopias frondosa) in reddish-brown-yellow colours and with a lot of skin flaps. Every time I took a photo and looked away to adjust my camera settings and looked again I found it hard to find the scopionfish again, it was so well camouflaged! They seemed to disappear among the algae and soft coral, even imitating the jerky movements of algae in a swell.\nI think we were lucky to find so many Rhinopias since they also seem to move around, so sometimes you might find them on one dive site, then at the on one next over…\nSee also my text about Rhinopias – are Rhinopias frondosa and Rhinopias eschmeyeri the same species?\nI only visited the dive sites on the east coast of Pantar close to Pura island. The southern part of Pantar is dominated by Gunung Sirung (862m), an active stratovolcano which errupted last in 2012. You can hike up to the crater rim from nearby village Kakamauta. There is large suphurous crater lake and active steam vents inside the caldera. A small natural harbour, Beangabang Bay, lies in the southeast of the volcano (not on the map) with three dive sites (Hot Property, Ribbon Eel Run and The Lava Flow), all of them on black sand with lots of critters. The water here is generally colder.\n19. Sea Apple Slopes: The further south you go the colder it gets but like in the Komodo islands but this also means some special animals are living here. This is a good place to find the rare filter-feeding sea cucumbers called sea apple (Pseudocolochirus violaceus). This sea cucumber is round like a football and of a bright red and purple colour with white or yellow stripes. Long colourful tentacles grab small plankton animals from the water and transfer them to the mouth opening on top of the sea cucumber. Small yellow sea cucumbers (Colochirus robustus) are also found here, some clinging in large numbers to the underside of the brownish leaflike sponges (Phyllospongia sp) found here.\n20. Bama: After a boat ride from Kepa with sightings of bottlenose and Fraser dolphins we dived on this nice slope on the east side of Pantar. The strait narrows so there is sometimes quite some current on this dive site. The whole dive site is just covered with fish – anthias, butterflyfishes, triggerfishes, surgeonfishes, damselfishes. Out in the blue lots of Long jawed Mackerels (Rastrelliger kanagurta) were swimming in a tightly bunched school, feeding on plankton with their mouths opening simultaneously and schools of fusiliers were passing by. When we came to the wall the current started to pick up and we were swept alongside. Our guide found nudis, flatworms and in one of the black coral bushes a longnose hawkfish. I spent a lot of time looking into the blue, though, because there were groups of bluefin trevallies (Caranx melampygus) out hunting. Deeper down I even saw a Napoleon wrasse, but my computer told me – too deep for you….\n21. Pan Abang: This is one of several dive site lying close to the Eco Dive Resort in northern Pantar. It is a good muck dive site where you can see interesting critters like Wunderpus, Mimic octopus, Rhinopias, ghostpipefishes, spearing mantis shrimp, frogfish, devil fish, pegasus and Coleman shrimps. You dive on sand interspaced with some corals.\n22. The Arch: This place is very beautiful! On the wall huge underwater cervices form a large arch at about 20 to 30 meter. Very healthy coral cover with whip corals and gorgonians. On some of the over 3 meter long whip corals you might find the rare Wire Coral Shrimp (Pontonides ankeri). I also saw some interesting animals in the upper part of the reef such as the marble dragonet, some special filefish and nudibranchs such as Jorunna funebris. Some dive sites have very impressive topography like big walls, arches, chimneys, cracks and overhangs, this is one of them!\n23. Babylon: Our dive guide who likes Bob Marley was trying to sing underwater to live up to the Caribbean name of this dive site while I was looking for nudibranchs and found 6 different species of them - Alor is always quite a good place for nudies. This is a nice dive site with some interesting overhangs at 30 meters.\n24. Coral Cliffs: A steep wall with a lot of whip corals, some 3 to 4 meter long. Nice dive but not so spectacular.\n25. The Edge (Umapura): For this wall dive it is well worth coming all the way to Ternate. When you perch on top the wall seems to go down and down and then disappear! There are overhangs and small crevices everywhere, sponges, black coral bushes and large corals cover everything. We had a leisurely dive along the wall, shining our lights into all the holes and crannies and just having a great time. And as a highlight, already on our way back and during the safety stop our guide Bram found a white frogfish perching on some blue sponges under an overhang! We spent our safety stop watching it luring and yawning in between.\n29. Cave Point: A nice easy dive on a wall riddled with small caves between 20 and 35 meter. The wall is nicely covered with corals and sponges and we found a lot of nudibranchs and had a nice long swim with a banded sea krait (Laticauda colubrina).\nI did several night dives, mainly on some of the muck dive sites in Kalabahi Bay and I really recommend that you include som, while you are staying in Alor since they were all truely spectacular!! On each we saw a great many nudibranchs, with several species I didn’t know before (Ceratosoma moloch, several Marionia species,Pleurobranchaea brockii, Phestilla melanobranchia and more), although I dive since 20 years. Then cuttlefishes and octopuses, shrimps and crabs, stargazers, stonefishes, pegasus sea moths, ghostpipefishes, frogfishes (a black frogfish at night, luring…..) and much more…!\nThe dive operators also offer night diving, mostly close to the resort in sheltered bays. Try places like Nite Delight No 30, The Mini Wall No 7 or some of the muck dive sites (4. Mucky Mosque, 5. Pertamina Pier and 6. Dive Logs) I described above.\nDescription of dive sites\n- Dive safety in South East Asia -\njudge the currents\nBali - Borneo and Kalimantan - Burma and Thailand - Malaysia (east coast) - Manado, Lembeh and Siau islands - Nusa Tenggara (Lombok, Sumbawa, Komodo, Flores, Alor) - Moluccas (Ambon, Banda, Halmahera) - Palawan (Sangat, Tubbataha) - Sulawesi - Sulawesi central - Visayas (Bohol, Cebu, Negros, Siquijor)\nPrint version reports\nAlor - Bali east - Bali north - Bali south - Bangka - Bohol - Borneo overview - Bunaken - Burma - Cebu - Flores - Gorontalo - Kalimantan - Komodo - Lankayan - Lembeh - Leyte - Lombok - Malaysia (east coast) - Manado - Moluccas - Negros - Palawan - Sabah and Sarawak - Sangat - Siau - Sipadan-Mabul - Siquijor - Sulawesi central - Sulawesi south - Sulawesi southeast - Togian and Banggai islands - Wallacea\nPrint version maps\nAlor - Ambon - Apo - Bali\n- Bohol - Borneo\n- Burma - Gorontalo\n- Kalimantan - Komodo\n- Lankayan - Lembeh\n- Leyte - Lombok\n- Malaysia (east coast) - Manado\n- Palawan (Tubbataha) - Sangat\n- Siau - Sipadan-Mabul\n- Siquijor - Sulawesi\nsouth - Togians\n|Grundsätze zur Berichterstattung über Tauchgebiete\n. Copyright Teresa Zubi (write to me)", "label": "Yes"}
{"text": "A recently published article in Equine Veterinary Education (EVE) was titled “Epidemiology of exertional heat illness in Thoroughbred racehorses in temperate eastern Australia: The role of extrinsic (environmental) factors in disease causation.” It was authored by Margaret Brownlow, BVSc, MVSc: Dip Vet Anaes, MNurs, MPubHealth, MMed (BMRI), MANZCVs, Racing Australia, Sydney, New South Wales, Australia; and J. X. Mizzi, Department of Regulation, Welfare and Biosecurity Policy, The Hong Kong Jockey Club, Sha Tin Racecourse, Hong Kong, Sha Tin, China.\n“A simple epidemiological model of disease causation is proposed for exertional heat illness (EHI) in Thoroughbred racehorses. The agent of disease causation that must be present for the condition to occur is strenuous exercise, producing substantial quantities of metabolic heat. This is stored during racing but must be dissipated rapidly in the post-race period to prevent core body temperature rising to a critical level and causing the clinical manifestations of EHI. Environmental factors are next in the epidemiological triad, and it is a common misconception that these are the direct cause of EHI. In fact, environmental conditions enable EHI by either diminishing the evaporative capacity of the environment or promoting internal heat gain. This article deals with the specific effects of the four thermal elements, separately and in combination, on individual thermo-effector mechanisms. The final component in the epidemiological triad is individual host factors. A critical premise of epidemiology is that conditions such as EHI may not occur randomly in a population but may be more likely to occur in some individuals due to the presence of certain factors that predispose them to the condition. For the purpose of assessing risk, it is not feasible to examine the balance between metabolic heat production and the intrinsic and extrinsic factors, which collectively determine each individual’s heat stress response. Therefore, the measurement of environmental factors remains the only practical way of obtaining a credible risk assessment for EHI, so that effective countermeasures can be instigated and the welfare of our racehorses ensured.”\nRead the entire open access article on the Wiley Online Library from BEVA here.", "label": "Yes"}
{"text": "Supplementary Materialssupplemental document. then evaluated within a subcutaneous PCa xenograft model (Computer3) by small-animal Family pet imaging and bio-distribution research. Outcomes NODAGA-RM1 and NODAGA-AMBA could be synthesized and radiolabeled with 64Cu and 18F-AlF successfully. 64Cu- and 18F-AlF-labeled NODAGA-RM1 confirmed excellent serum balance and tumor-imaging properties in the in vitro balance assays and in vivo imaging research. 64Cu-NODAGA-RM1 exhibited tumor uptake beliefs of 3.3 0.38, 3.0 0.76, and 3.5 1.0 percentage injected dosage per gram of tissues (%ID/g) at 0.5, 1.5, and 4 h after injection, respectively. 18F-AlF-NODAGA-RM1 exhibited tumor uptake beliefs of 4.6 1.5, 4.0 0.87, and 3.9 0.48 %ID/g at 0.5, 1, and 2 Gefitinib kinase inhibitor h, respectively. Bottom line The high-stability, effective tumor uptake and optimum pharmacokinetic properties high light 18F-AlF-NODAGA-RM1 being a probe with great potential and scientific application for your pet imaging of prostate tumor. QMA SepPak Light cartridge (Waters) set with 18F (1.1 GBq [30 mCi]) was washed with 2.5 mL of metal-free water. The 18F was eluted through the cartridge with 400 L of 0 then.4 M KHCO3, that 200-L fractions had been taken. The pH of the answer was adjusted to 4 with metal-free glacial acetic acid. AlCl3 (2 mM, 3 L) in 0.1 M sodium acetate buffer (pH 4) and 10 L of peptide (1 mg/mL in dimethyl sulfoxide) were then added to the reaction solution sequentially. The reaction mixtures were incubated at 100C for 15 min. The labeled peptides were then purified by semipre-parative HPLC. The fractions made up of the desired products were collected and rotary-evaporated to remove the solvent. The products were reconstituted in phosphate-buffered saline and exceeded through a 0.22-m Millipore filter into sterile vials for the subsequent in vitro and in vivo experiments. Cell-Binding Assays The cell-binding assay was performed similarly as previously reported (19,35). The detailed procedures are included in the supplemental file. Mouse Serum Stability The in vitro stability of the PET probes was evaluated by incubation with mouse serum (1 mL) at 37C. The solutions were filtered using a NanoSep 10 K centrifuge (Pall Corp.) to isolate low-molecular-weight radiocomplexes. The samples were analyzed by the radio-HPLC, and the percentages of intact PET probe were determined by quantifying the peaks corresponding with the intact probe and degradation products. Small-Animal PET Imaging The animal procedures were performed according to a protocol approved by the Stanford University Institutional Animal Care and Use Committee. The establishment of the PC3 tumor mice Rabbit Polyclonal to AKAP10 model and the procedure for small-animal PET are shown in the supplemental file. The PC3 xenograftCbearing mice were injected with approximately 1.85 MBq (50 Ci) of either 64Cu-NODAGA-RM1 or 64Cu-NODAGA-AMBA via the tail vein (= 4 for each group). At the indicated occasions Gefitinib kinase inhibitor after injection (0.5, 1.5, and 4 h), the mice Gefitinib kinase inhibitor were anesthetized with isoflurane (5% for induction and 2% for maintenance in 100% O2) using a knock-down box. Five-minute static scans were then obtained. The PC3 xenograftCbearing mice were injected with 0.37 MBq (10 Ci) of either 18F-AlF-NODAGA-RM1 or 18F-AlF-NODAGA-AMBA probe via the tail vein (= 5 for each group). Blocking studies were performed via tail vein injection of the 18F probe with cold AMBA (10 mg/kg of body weight) (= 5). At 0.5, 1, and 2 h after injection, the small-animal PET images were obtained. The small-animal PET images were reconstructed using the 2-dimensional ordered-subsets expectation maximization algorithm. No background correction was performed. The regions of interest (ROIs; 5 pixels for coronal and transaxial slices) were designated over the tumor on decay-corrected whole-body coronal images. The maximum counts per pixel per minute were obtained from the ROIs and converted to counts per milliliter per minute using a calibration constant. On Gefitinib kinase inhibitor the basis of an assumed tissue density of 1 1 g/mL, the ROIs were converted to counts per gram per min. The image ROICderived percentage of the injected radioactive doses per gram of tissue (%ID/g) values had been dependant on dividing matters per gram each and every minute by injected dosage. No attenuation modification was performed. Pet Biodistribution Research The Computer3 xenograftCbearing nude mice (= 4 for every group) had been injected with around 1.85 MBq (50 Ci) of 64Cu-AlF-NODAGA-RM1 via the tail vein and sacrificed at 2 and 24 h after injection. The tumor and regular tissue appealing had been weighed and taken out, and their degrees of radioactivity had been measured utilizing a -counter-top. The uptake of radioactivity in the tumor and regular tissues was portrayed as %Identification/g. Similarly, Computer3 xenograftCbearing nude mice (= 5 for every group) had been injected with around 0.37 MBq (10 Ci) of 18F-AlF-NODAGA-RM1 via the tail vein and sacrificed at 2 h after shot. The 18F-AlF-NODAGA-RM1 preventing research was performed by coinjection from the probe using the AMBA peptide (10 mg/kg of.", "label": "Yes"}
{"text": "PCR Covid Testing in Austin: Nasal and Saliva Options\nAustin Rapid Test has a variety of Covid test types available for our customers, and can administer each of them from the safety and convenience of your home or office. Some tests have different names used for the same or similar tests, so it can all be very confusing when researching the type of Covid test you need or where in Austin you can find a specific type of Covid test.\nThis page is dedicated to one of the diagnostic tests we provide: the polymerase chain reaction (\"PCR\") test.\nA diagnostic test can show if you have an active coronavirus infection. Currently there are two types of diagnostic tests – molecular tests, such as PCR tests, that detect the virus’s genetic material, and antigen tests that detect specific proteins from the virus.\n\"Molecular Tests\" are also known by other names/terms such as viral tests, nucleic acid amplification tests (NAAT), RNA tests, and PCR tests. In fact, the PCR Test is a type of NAAT test.\nDifferent Types of PCR tests\nYes, there are different types of PCR tests, though most websites don't necessarily differentiate them and simply call them all \"PCR\" tests. With said, there is the standard PCR, RT-PCR, Hot Start PCR, qPCR, and RT-qPCR.\nAt Austin Rapid Test, we offer the RT-PCR Covid test and our nurses can administer the test by either a nasal swab or by collecting your saliva.\nLike our Nasal swab PCR test, the Saliva Covid test needs to be sent to a lab for processing. Right now, it is sent to a specialty lab slightly further than our nasal PCR test lab, so it occasionally takes a little longer to get results back for the saliva covid tests.\nOur partner lab has guaranteed a turnaround time on Saliva Covid tests of 72 hours, though they tend to get us the results faster than that. Our nasal PCR test results are often returned in less than 24 hours but are guaranteed to be provided in no more than 48 hours.\nIs the Accuracy of the Nasal Swab PCR Covid Test Higher than it is with the Saliva PCR Covid Test?\nSince the early days of the pandemic, clinicians and researchers have been looking for alternatives to nasopharyngeal swabs due to the discomfort that many people experience with this specimen collection method.\nAn accurate identification of respiratory viruses is critically affected by the source of clinical specimens. While several studies on up to 15 common respiratory viruses suggest that the use of nasopharyngeal swabs provides a higher sensitivity than that of nasopharyngeal washings or oropharyngeal swabs, this is not necessarily the case for SARS-CoV-2, as the infectivity and the predilection for transmission may differ significantly between viruses.\nCurrently, the available data comparing the sensitivity for SARS-CoV-2 detection using nasal, pharyngeal, or oral swab are very limited. One study from a Chinese group examined 213 hospitalized SARS-CoV-2 patients with a total of 205 oropharyngeal and 490 nasopharyngeal swabs at various time points of disease course. They found that nasopharyngeal swabs have overall higher positive rates (53.6%-73.3%) than oropharyngeal (throat) swabs (11.1%-61.3%), regardless of whether the patients were in mild or severe disease conditions.\nSince saliva is easily collected and clinically informative for disease detection, the consideration that maximizes the benefit of using saliva as a diagnostic fluid deserves more attention. Researchers found that the agreement between the saliva and swab administered through the mouth was 93%, and that sensitivity was 96.7%. The swab administered through the nose and saliva had a result agreement of 97.7%, with sensitivity of 94.1%.\nThis is a rapidly moving research topic and the current evidence is not peer-reviewed and, therefore, is still far from leading to a solid conclusion. In other words, it is still too early to fully determine if the accuracy of Saliva PCR tests and Nasopharyngeal PCR tests is significantly different.\nAs always, determining which test is best and most appropriate for any individual is a decision best made with the guidance of your healthcare provider.", "label": "Yes"}
{"text": "Make a difference for the lake you love! Join a Shedd Great Lakes Action Day to spend a day outdoors, cleaning local beaches, lakes and forest preserves. You’ll help animals from frogs to fishes and have fun doing it!\nProtecting our Great Lakes and other local waters\nTogether, we all can take actions to protect the Great Lakes from the threats of pollution, invasive species and loss of wetland and shoreline habitats. Our team of policy experts works closely with elected officials and conservation partners to advocate for science-based solutions to our lakes' problems.\nOur field biologists and other conservation experts recruit teams of citizen scientists—like you!—to assist with short- and long-term projects, from collecting and documenting beach litter to restoring coastal and wetlands habitats. These collaborations are improving our Great Lakes \"neighborhood\" for wildlife and people alike.\nGet involved in a Great Lakes Action Day activity near you!\nCommunity workdays and locations\nfor individuals and families\nWe hosts beach cleanups at sites along the Lake Michigan shoreline through the Alliance for the Great Lakes Adopt-a-Beach™ program. Volunteers work in teams, combing the beach for litter and recording data on their findings to support effective coastal management.\nHabitat and wildlife monitoring\nTo measure the impact of our work on local wildlife, participants can strap on waders to assess water quality in local streams and monitor threatened and endangered plant species.\nInvasive plant removal\nMake a positive difference for local wildlife, from frogs to migratory birds, by taking action to prevent the spread of harmful ecological invaders. Participants will learn about natural habitats near Chicago as well as the impact of invasive plant and animal species.\nAmphibian habitat restoration\nBlue-spotted salamanders and chorus frogs are among the native amphibians in our local woodlands and wetlands. We work with the Forest Preserves of Cook County to restore local amphibian habitats, a project that combines land-management expertise with a deep knowledge of amphibians' needs.\nAge and Requirements\nAll ages. Individuals, families and groups up to 100 people can be accommodated.\nWhat to Bring\nReusable water bottles, snacks and sunscreen, and weather-appropriate outdoor clothing and shoes\n- Beach cleanup\n- Habitat and wildlife monitoring\n- Invasive plant removal\n- Habitat restoration\nWhat to Know\n• All events are weather-dependent.\n• Transportation is available for select school and youth groups.\n• Participant waivers are required.\nCorporate group GLAD opportunities are reserved for current corporate partners. Email to learn more.", "label": "Yes"}
{"text": "To figure out these counterintuitive findings, the researchers conducted an experiment in a hotel room. They rounded up some lizards, gave them a perch, and used a leaf blower to the effects of high winds. They set up a net to catch any lizards that lost their grip. As the artificial wind blew, the lizards so the perch took most of the air flow. But their hind legs would stick out, and if those limbs stuck out too far, they acted as sails. “Eventually those back legs were blown off the perch, and the lizards were just holding on with their front two legs. And they could only hold on like that for so long as the wind speed further and further, until eventually they were blown off the perch and into the So shorter back legs gave a advantage. A trait that might be passed on to the next lizard generation.Answer (score 79+):\nYou're not allowed to see it! Just for Premium Users! Click here to Sign Up!", "label": "Yes"}
{"text": "Paper No. 237-15\nPresentation Time: 5:15 PM\nEXTREME ENDEMISM OF LATE CRETACEOUS MARINE OSTRACODS IN THE US GULF COASTAL PLAIN\nOstracods are abundant and diverse fossils in the North American coastal plain sediments. Detailed sampling of late Campanian-Maastrichtian marine deposits on the eastern flank of the Mississippi Embayment reveals extremely localized occurrences, often at only a single outcrop, of rare but diverse species of a clade of ornamented ostracods that have been assigned to the genus Anticythereis. Taxonomic studies indicate that there are more than 20 previously undescribed species in this clade in the Atlantic and Gulf coastal plains, although none have been reported from the western flank of the Mississippi Embayment and no species occurs in both the Atlantic and Gulf coastal plains. Recently, 11 of those species from the TN-MS-AL region were named and described and assigned to 4 new genera and a new Subfamily Anticytherideinae. The subfamily is characterized mainly by a distinctive muscle scar pattern and a pair of inverted platform structures on the inside of the carapace that corresponds to the inner surface of the postocular sulcus. The clade first appeared in the later Campanian Radotruncana calcarata planktonic foraminiferal taxon range zone and became extinct at the K/Pg boundary event. Several species were found at a single outcrop of the Providence Sand of eastern Alabama, whereas others occur only in the Owl Creek Formation of northern Mississippi. Although there have been many species assigned to the genus Anticythereis from continents exclusive of North America, their endemism indicates that none of them should be assigned to that genus and represent taxa that evolved in their respective areas. This endemism makes ostracods very useful tools in deciphering plate tectonic reconstructions of the past.", "label": "Yes"}
{"text": "The involvement of oxidative stress in determining the severity and progress of pathological processes in dystrophin-deficient muscles.\nLanguages of publication\nIn both forms of muscular dystrophy, the severe Duchenne’s muscular dystrophy (DMD) with lifespan shortened to about 20 years and the milder Becker dystrophy (BDM) with normal lifespan, the gene defect is located at chromosome locus Xp21. The location is the same in the experimental model of DMD in the mdx mice. As the result of the gene defect a protein called dystrophin is either not synthesized, or is produced in traces. Although the structure of this protein is rather well established there are still many controversies about the dystrophin function. The most accepted suggestion supposes that it stabilizes sarcolemma in the course of the contraction-relaxation cycle. Solving the problem of dystrophin function is a prerequisite for introduction of an effective therapy. Among the different factors which might be responsible for the appearance and progress of dystrophic changes in muscles there is an excessive action of oxidative stress. In this review data indicating the influence of oxidative stress on the severity of the pathologic processes in dystrophy are discussed. Several pieces of data indicating the action of oxidative damage to different macromolecules in DMD/BDM are presented. Special attention is devoted to the degree of oxidative damage to muscle proteins, the activity of neuronal nitric oxide synthase (nNOS) and their involvement in defining the severity of the dystrophic processes. It is indicated that the severity of the morbid process is related to the degree of oxidative damage to muscle proteins and the decrease of the nNOS activity in muscles. Estimation of the degree of the destructive action of oxidative stress in muscular dystrophy may be a useful marker facilitating introduction of an effective antioxidant therapy and regulation of nNOS activity.\n- Bredt DS (1999) Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic Res 31: 577-596.\n- Brenman JE, Chao DS, Xia H, Aldape K, Bredt DS (1995) Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 82: 743-752.\n- Brown RH (1995) Free radicals, programmed death and muscular dystrophy. Curr Opin Neurol 8: 373-378.\n- Chang WJ, Iannaccone ST, Lau KS, Masters BS, McCabe TJ, McMillan K, Padre RC, Spencer MJ, Tidball JG, Stull JT (1996) Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy. Proc Nat Acad Sci USA 93: 9142-9147.\n- Crosbie RH (2001) NO vascular control in Duchenne muscular dystrophy. Nat Med 7: 27-29.\n- Degl’Innocenti D, Pieri A, Rosati F, Ramponi G (1999) Oxidative stress and calcium homeostasis in skin fibroblasts. IUBMB Life 48: 391-396.\n- Franco A, Lansman JB (1990) Calcium entry through stretch-inactivated ion channels in mdx myotubes. Nature 344: 670-673.\n- Gee SH, Madhavan R, Levinson SR, Caldwell JH, Sealock R, Froehner SC (1998) Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. J Neurosci 18: 128-137.\n- Gucuyener K, Ergenekon E, Erbas D, Pinarli G, Serdaroglu A (2000) The serum nitric oxide levels in patients with Duchenne muscular dystrophy. Brain Dev 22: 181-183.\n- Haycock JW, Jones P, Harris JB, Mantle D (1996a) Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage: a histochemical, immunocytochemical and electron microscopical study in vitro. Acta Neuropathol 92: 331-340.\n- Haycock JW, Mac Neil S, Jones PJ, Harris JB, Mantle D (1996b) Oxidative damage to muscle protein in Duchenne muscular dystrophy. NeuroReport 8: 357-361.\n- Haycock JW, Mac Neil S, Mantle D (1998a) Differential protein oxidation in Duchenne and Becker muscular dystrophy. NeuroReport 9: 2201-2207.\n- Hunter M, Ian S, Mohamed JB (1986b) Plasma antioxidants and lipid peroxidation products in Duchenne muscular dystrophy. Clin Chim Acta 255: 123-132.\n- Irintchev A, Wernig A (1987) Muscle damage and repair in voluntarily running mice: strain and muscle differences. Cell Tissue Res 249: 509-521.\n- Kar NC, Pearson CM (1979) Catalase, superoxide dismutase, glutathione reductase and thiobarbituric acid-reactive products in normal and dystrophic human muscle. Clin Chim Acta 94: 277-280.\n- Kasai T, Abeyana K, Hashiguchi T, Fukunaga H, Osame M, Maruyama I (2004) Decreased total nitric oxide production in patients with Duchenne muscular dystrophy. J Biomed Sci 11: 534-537.\n- Koenig M, Monaco AP, Kunkel CM (1988) The complete sequence of dystrophin predicts a rod-shaped cytosketal protein. Cell 53: 219-228.\n- Kong J, Anderson JE (1999) Dystrophin is required for organizing large acetylocholine receptor aggregates. Brain Res 839: 298-304.\n- Levine RL, Williams JA, Stadman ER, Shacter E (1994) Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 233: 346-357.\n- Matkovics B, Laszlo A, Szabo L (1982) A comparative study of superoxide dismutase, catalase and lipid peroxidation in red blood cells from muscular dystrophy patients and normal controls. Clin Chim Acta 118: 289-292.\n- Mechler F, Imre S, Dioszeghy P (1984) Lipid peroxidation and superoxide dismutase activity in muscle and erythrocytes in Duchenne muscular dystrophy. J Neurol Sci 63: 279-83.\n- Mendell JR, Engel WK, Derrer EC (1971) Duchenne muscular dystrophy: Functional ischemia reproduces characteristic lesions. Science 172: 1143-1145.\n- Murphy ME, Kehrer JP (1989) Oxidative stress and muscular dystrophy. Chem-Biol Interact 69: 101-178.\n- Nakae Y, Stoward PJ, Kashiyama T, Shono M, Akagi A, Matsuzaki T, Nonaka I (2004) Early onset of lipofuscin accumulation in dystrophin-deficient skeletal muscles of DMD patients and mdx mice. J Mol Histol 35: 489-499.\n- Niebroj-Dobosz I, Fidziańska A, Hausmanowa-Petrusewicz I (2001) Does normal nitric oxide synthase prevent pathologic muscle changes in dystrophin deficiency? Basic Appl Myol 11: 105-110.\n- Niebroj-Dobosz I, Fidziańska A, Hausmanowa-Petrusewicz I (2002) Oxidative damage to muscle proteins in dystrophinopathies. Acta Myol 21: 12-17.\n- Ragusa RJ, Chow CK, Porter JD (1997) Oxidative stress as a potential pathogenic mechanism in animal model of Duchenne muscular dystrophy. Neuromuscul Disord 7: 379-380.\n- Rodrigues MCh, Tarnopolsky MA (2003) Patients with dystrophinopathy show evidence of increased oxidative stress. Free Radic Biol Med 34: 1217-1220.\n- Slater TF (1984) Free-radical mechanisms in tissue injury. Biochem J 222: 1-15.\n- Tidball JG, Lavergne B, Lau KS, Spencer MJ, Stull JT, Wehling M (1998) Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle. Am J Physiol 82: C260-266.\n- Wink DA, Hanbauer I, Krishna MC, DeGraff W, Gamson J, Mitchell JB (1993) Nitric oxide protects against cellular damage and cytotoxity from reactive oxygen species. Proc Natl Acad Sci USA 90: 9813-9817.\n- Wink DA, Cook JA, Pacelli R, Liebman J, Krishna MC, Mitchell JB (1995) Nitric oxide (NO) protects against cellular damage by reactive oxygen species. Toxicol Lett 82-83: 221-226.\n- Woodford FP, Whitehead TP (1998) Is measuring serum antioxidant capacity clinically useful? Ann Clin Biochem 35: 48-56.\n- Zubrzycka-Gaarn EE, Bulman DE, Karpati G, Burghes AH, Belfall B, Klamut HJ, Talbot J, Hodges RS, Ray PN, Worton RG (1988) The Duchenne muscular dystrophy gene product is localized in sarcolemma of human skeletal muscle. Nature 333: 466-469.\nPublication order reference", "label": "Yes"}
{"text": "A PCR travel test differs from other Covid-19 medical options. They deliver results to both individuals and healthcare providers. More so, these can show if someone has SARS-CoV-2 previously. However, there are disadvantages to such checks. It can vary in specificity. These kits don’t detect non-target viruses. Also, you may not use it for sensitivity.\nWhat do experts say about these solutions?\nThe CDC has made strict rules for these kits. For example, we can’t use the results of the PCR travel test for Coronavirus to diagnose someone with an infection. Furthermore, it takes one week or even three weeks for the body to produce antibodies. This is after anyone gets the virus. So, these kits would be wrong at this stage.\nAlso, certain people may need longer to build pathogens. These cannot detect antibodies in anyone with an active infection. That’s, based on when a doctor diagnosed someone. It also depends on the date of the examination.\nA Review of the CDC’s proposed options\nCDC’s serological method represents one of the checks. These methods detect antibodies. After all, it’s a blood segment. These use live viruses. Likewise, they use a specific protein.\nSerological-based checks identify pathogens formed because of the SARS-CoV-2. The body uses them to prevent the connecting of pathogens against other viruses. These other illnesses cause less severe diseases. An example of such a disease is colds.\nThese tests have a more than 99 percent accuracy. It also checks for Covid-19 include a 96 percent reliability dependent on initial procedures. One may use such kits to classify the previous infection with SARS-CoV-2 in individuals diagnosed. In this case, it ranges from at least 1 to 3 weeks ago.\nWhat is the other method?\nCDC also created blood-based kits in the laboratory. These kits helped to determine how most people have the disease. This’ the virus that triggers Covid-19. CDC also uses the method to determine the efficiency of industrial samples.\nBesides, they’re unique proteins that are formed in reaction to infection. These can be contained in the blood of patients who are examined following infection. In turn, that displays an inflammatory response to the disease. The results of antibody-based kits are important in detecting previous infections. This is essential for those with few or no symptoms.\nCDC’s serological option has been developed for surveillance purposes. Thus, its for Covid-19 to offer knowledge required to direct the response to the pandemic. The knowledge also helps to safeguard the population’s safety. These tests for the disease are not intended for individual use. That is, to check individuals who want to know if they have been infected with SARS-CoV-2 beforehand.\nAfter all, the CDC decides commercial-based kits performance.", "label": "Yes"}
{"text": "By: Taylor Darnell, agronomy master’s student with UF/IFAS Center for Aquatic and Invasive Plants (CAIP)\nImagine a lakefront house on a pristine lake in Florida. Now, imagine that waterfront view obstructed by tussocks, aquatic plants, and mosquitos. That does not sound enjoyable, does it? This is where aquatic plant management (APM) comes into the spotlight. There are multiple APM tools such as biological, chemical, mechanical, and cultural controls used to remove aquatic unpleasantries.\nA cultural method of aquatic plant control, drawdowns, are among the most infrequently used APM tools in Florida. In a drawdown, the water level is lowered within a lake, pond, or another waterbody. Drawdowns provide many benefits to public recreation, homeowners, native species, and can create opportunities for infrastructure repair and improvement.\nThere are two types of drawdowns: surface and subsurface. Surface drawdowns are the most common form of drawdowns and, since they involve surface water, they are used for aquatic plant management. Surface drawdowns are not a novel concept. This type of drawdown occurs naturally as droughts, but can also be controlled by water resource management techniques like controlled releases of water from behind an impoundment. An impoundment can be anything from a simple earthen dam to a concrete and steel dam and lock system that creates a non-natural water body. Subsurface drawdowns, however, remove water from underground sources.\nDrawdowns are not practiced regularly on most waterbodies in Florida, yet this APM tool has been used extensively on Rodman Reservoir located in Putnam County, Florida, for decades.\nEvery three to four years, the water level in Rodman Reservoir is decreased by approximately 10 feet using drawdowns. This process usually takes seven months. During this time, most of the littoral zones, or shallow water areas, are drained and exposed to direct sunlight and air for six months. Consequently, aquatic plants such as hydrilla (Hydrilla verticillata), coontail (Ceratophyllum demersum), eelgrass (Vallisneria americana), water lettuce (Pistia stratiotes), and water hyacinth (Eichhornia crassipes) dry out and die. Previous drawdown research has shown that, if properly timed, two or more drawdown cycles can significantly reduce the amount of hydrilla biomass in a system.\nDrawdowns on Rodman Reservoir are carefully planned between the U.S. Army Corps of Engineers, Florida Department of Environmental Protection (DEP), Florida Fish and Wildlife Conservation Commission (FWC), and water management districts, with careful consideration not to disturb or damage fragile or protected habitats.\nIn 2019, a drawdown was conducted to control free-floating aquatic plants in order to maintain one of the best largemouth bass (Micropterus salmoides) fisheries in Florida by balancing the bluegill (Lepomis macrochirus) population to the largemouth bass population. These water level fluctuations are necessary to spur native plant growth, such as spatterdock (Nuphar macrophyllum), cattail (Typha spp.), and Illinois Pondweed (Potamogeton illinoensis) as well as decreasing bluegill populations and increasing the largemouth bass populations. For more information on this drawdown, visit this report.\nFor even better fishing conditions, many anglers frequent Rodman Reservoir during a drawdown because of the way fish tend to cluster or hide while the water is decreased. To help keep the concentrated populations of largemouth bass in the system and to reduce the number of smaller, non-game prey, and nuisance fish, bass fishing on Rodman Reservoir during a drawdown is catch and release only.\nFor more information, explore the following links for further reading:\nThis blog post was written by Taylor Darnell, an agronomy master’s student with UF/IFAS CAIP. Questions or comments can be sent to the UF/IFAS CAIP communications manager at firstname.lastname@example.org.\nFollow UF/IFAS CAIP on social media at @ufifascaip. Read more blogs like this one on the UF/IFAS CAIP blog.\nUF/IFAS Center for Aquatic and Invasive Plants. Turning Science Into Solutions.", "label": "Yes"}
{"text": "Laura Uribe Uribe\nNanoscience, Materials and Chemical Engineering\nAlex Fragoso Sierra\nLaura Uribe received her bachelor's degree in Chemical Engineering from University of Los Andes (Bogota, Colombia) where her thesis about the development of a radar absorbent coating using nanoferrites earned her a laurate qualification. During her BSc she was an intern at Henkel where she worked in the R&D laboratory of the adhesive's division. She holds a MSc in Nanoscience, Materials and Processes from University Rovira i Virgili where she first joined Interfibio Research Group under the supervision of Professor Ciara O'Sullivan and Dr Mayreli Ortiz. Her master's thesis was a novel approach of next generation sequencing using electrochemical techniques, that were used to detect genetic markers related to predisposition to certain diseases. The work was published in the Biosensors and Bioelectronics Journal. After her master she joined Sika, a multinational company of the chemical industry for a Trainee program based in Brazil, which strengthened her industrial and international experience. Nowadays she's working as a PhD student back at URV's Interfibio Research Group and she is part of the project Ciguasensing in collaboration with IRTA (Institute of Agrifood Research and Technology of Catalonia).\nProject: Towards extraction and purification protocols for marine toxins based on cyclodextrin-derived nanomaterials\nMonitoring methods for marine toxins -such as ciguatoxins (CTX) and okadaic acid (OA)- present in seawaters are of high interest to support sustainable growth in the marine and maritime sectors altogether. Okadaic acid and ciguatoxins are responsible for producing diarrhetic shellfish poisoning (DSP) and ciguatera, food poisoning diseases that affect the human health and can produce economic losses to the shellfish industry. Ciguatoxins and okadaic acid molecules are worm-shaped polycyclic ethers that possess a remarkably hydrophobic character. Meanwhile, cyclodextrins (CDs) are cyclic oligosaccharides with a cone-like shape and a hydrophobic central cavity. Given their low toxicity, great biocompatibility and good complexation capacity with a variety of molecules, cyclodextrins have been extensively used as host molecules in the pharmaceutical, cosmetic, agrochemical, food, and biomedical industries. Therefore, the typically hydrophobic character of CTXs and OA makes them perfect guests to form inclusion complexes with ß-cyclodextrins. The aim of my work is to study the molecular interactions between the CTX, the OA and the CDs, which have not yet been studied, and thus, to develop extraction/purification/pre-concentration protocols based on CD-derived nanomaterials.", "label": "Yes"}
{"text": "Zeenews BureauChicago: In a breakthrough research, US scientists have begun testing drugs on so-called lung-on-a-chip, which though looks nothing like a human organ, mimics the essential functions of a healthy lung. The technology can aid medical research and drug development, and may reduce the need for animal testing in the future.The flexible piece of silicone rubber about the size of a memory stick has a porous matrix in the middle that host lung cells on one side, where air flows over them, and capillary cells on the other side, where a blood-like fluid flows over them. Vacuum pumps applied on both sides of the chip mimic the way human tissue stretches during breathing.The team from Harvard`s Wyss Institute for Biologically Inspired Engineering is putting its artificial lung to the test, using the device to recreate pulmonary edema, a potentially deadly condition characterized by fluid and blood clots in the lungs, and then treating it with an experimental drug from GlaxoSmithKline.For the study, the team injected interleukin-2 or IL-2, a cancer drug that can cause pulmonary edema into the blood channel of the device. The drug caused fluid to start leaking across the membrane, reducing the amount of volume of air in the other channel. Blood plasma crossed into the air channels and started to clot. On turning on the vacuum to simulate breathing, fluid leakage increased, suggesting that breathing may make the condition worse.The team next used their model to test TRPV4 channel blocker, a new class of drug being developed by GlaxoSmithKline. They found that treating the tissues in the device with the Glaxo drug before exposing it to IL-2 prevented blood vessel leakage in the device.\nAzam Khan calls Modi a Fascist\nDon`t rush with the Lokpal :BJP\nCBI questions Madhu Koda on Coalgate\nStop govt from appointing new Army chief: BJP to Election Commission", "label": "Yes"}
{"text": "Education; Environmental education; Podcast; Public Lecture;\nWilliam Souder’s work has appeared in many publications, including the Washington Post, New York Times, and Harper’s. He is the author of three books. A Plague of Frogs (2000) followed the investigation into outbreaks of deformed frogs across...\nWilliam Finley viewing the wildlife at Klamath Marsh during a 1903 photography trip taken with his partner Herman Bohlman. Finley and Bohlman's photographs of the area in 1903 would later help Klamath become a bird refuge in 1905.\nBirds; History; Fishing; Fishes; Recreation; Rivers and streams; Wildlife refuges;\nWilliam Finley examining his catch at Klamath Marsh during a 1905 photography trip with his partner Herman Bohlman. Finley and Bohlman's photographs of the area in 1905 would later help Klamath become a bird refuge in 1908.\nWilliam Finley at Klamath Marsh, 1905. Due to Finley and Bohlman's photography of the area in 1905, Klamath was named a bird refuge in 1908. \"Here lay the land of my dreams. After nearly 20 years of waiting, I was looking out over this place of...\nWilliam Finley and Herman Bohlman getting ready for a boat trip at Tule lake, Klamath Marsh, in 1905. Klamath would later become a bird refuge in 1908 due to photographs taken by Finley and Bohlman of the area in 1905.", "label": "Yes"}
{"text": "Need some pigeon predators\nYour article about suspected pigeon droppings contaminating Fountain Creek conjured up memories of a similar problem that closes Lake Michigan beaches in Wisconsin and Illinois. It is now a foregone conclusion that Lake Michigan beaches close after Midwest rainstorms wash out the sandy beaches, leaching gull droppings into the Great Lake and causing E. Coli levels to skyrocket.\nLike Fountain Creek, expensive government studies back then never seemed to precisely pinpoint the culprit of the contamination - until a few communities started finding ways to move the protected species (gulls) off their beaches in the direction of neighboring dunes. Then a pattern arose, as some beaches remained opened while others just miles away were closed. Gull abatement in one community revolved around shooting off a cannon and having trained dogs chase waddling loiterers at intervals that made the flock find quieter, more gentile locales.\nThe problem is not gulls or pigeons per se; the problem is that there are no natural predators to cull the flocks. In one community in Wisconsin they began to introduce foxes into natural areas near the beaches, which quickly reduced the flocks. I also know of communities that bring in falcons and hawks to reduce pigeon populations. All these remedies are cheaper than government studies and fancy human abatement programs and can keep water with fewer E. Coli problems.", "label": "Yes"}
{"text": "The paraffin embedded specimens of 35 Aujeszky's disease cases in pig were examined with Avidin-biotin-complex (ABC) method to detect Aujeszky's disease viral antigen. Eighty percent of the cases (28/35) gave positive reaction. Aujeszky's disease viral antigen was detected in cerebrum (17/28), cerebellum (12/17), medulla oblongata (7/8), spinal cord (4/4), and tonsils (5/11). It is concluded that ABC method is a sensitive, reliable and rather simple technique to diagnose Aujeszky's disease on paraffin embedded tissue section.\nMutoh, Yuko; Sunyasootcharee, Boonmee; Tateyama, Susunu; Tesaprateep, Ted; Yamaguchi, Ryoji; and Sailasuta, Achariya\n\"Retrospective Study of Aujeszky's Disease in Pig in Thailand using Immunohistochemical Method,\"\nThe Thai Journal of Veterinary Medicine: Vol. 20:\n4, Article 5.\nAvailable at: https://digital.car.chula.ac.th/tjvm/vol20/iss4/5", "label": "Yes"}
{"text": "- Does cooking food kill botulism?\n- Does frying kill botulism?\n- Does lemon juice kill botulism?\n- How do you know if honey has botulism?\n- Can botulism go away on its own?\n- Can you tell if a can has botulism?\n- Does boiling kill botulism?\n- Are dented cans OK?\n- How do you get rid of botulism?\n- Can you smell botulism?\n- Why are dents in cans bad?\nDoes cooking food kill botulism?\nThe toxin that Clostridium botulinum produces is among the most deadly food toxin known.\nFortunately, heat destroys the toxin and cooking is the best way to control botulism..\nDoes frying kill botulism?\nbotulinum, and anti-toxin is not useful for prevention. Heating to high temperatures will kill the spores. … The toxin is heat-labile though and can be destroyed at > 185°F after five minutes or longer, or at > 176°F for 10 minutes or longer. Boiling homecanned foods for 10 minutes or longer is recommended.\nDoes lemon juice kill botulism?\nAcidifying low-acid foods will help to kill bacteria but heating should still be incorporated into the process. Thus, lemon juice, citric acid, vinegar and other acidic elements can be used to increase the acidity of preserved foods that are being preserved using a heating method.\nHow do you know if honey has botulism?\nSymptoms of foodborne botulism include marked fatigue, weakness, and vertigo often followed by blurred vision, dry mouth and difficulty in swallowing and speaking. Vomiting, diarrhoea or constipation may also occur.\nCan botulism go away on its own?\nThe earliest symptoms involve the eyes and face, because nerves controlling their function are affected most quickly by the botulism toxin. Early or mild symptoms, which may go away on their own, include: Abdominal pain, nausea, vomiting or diarrhea (not usually present in wound botulism)\nCan you tell if a can has botulism?\nNever taste food to determine if it is safe. Do not taste or eat food that is discolored, moldy, or smells bad. Do not taste or eat food from cans that are leaking; have bulges or are swollen; or look damaged, cracked, or abnormal. Do not taste or eat food from a can that spurted liquid or foam when it was opened.\nDoes boiling kill botulism?\nBecause botulinum toxin is destroyed by high temperatures, persons who eat home-canned foods should consider boiling the food for 10 minutes before eating it to ensure safety.\nAre dented cans OK?\nIf a can containing food has a small dent, but is otherwise in good shape, the food should be safe to eat. Discard deeply dented cans. A deep dent is one that you can lay your finger into. Deep dents often have sharp points.\nHow do you get rid of botulism?\nNormal thorough cooking (pasteurisation: 70°C 2min or equivalent) will kill Cl. botulinum bacteria but not its spores. To kill the spores of Cl. botulinum a sterilisation process equivalent to 121°C for 3 min is required.\nCan you smell botulism?\nFoodborne botulism is a rare but serious illness caused by eating foods that are contaminated with the disease‑causing toxin. You cannot see, smell, or taste botulinum toxin – but taking even a small taste of food containing this toxin can be deadly.\nWhy are dents in cans bad?\nBotulism, caused by the bacteria clostridium botulinum, occurs when a dent or damage to a can creates even a pinhole-size opening. The mixture of air and moisture from the food within the can spurs growth of the bacteria, and the food becomes contaminated. … Dented cans are the biggest culprit of botulism.", "label": "Yes"}
{"text": "Google AI can spot advanced breast cancer more effectively than humans\nIt's up to 99 percent accurate in the right conditions.\n'Overwatch' skin raised more than $10 million for breast cancer research\nMercy mains can do more than just heal teammates, it seems.\nFDA greenlights 23andMe's direct-to-consumer cancer risk test\nYou don't have to go through a doctor to understand your chances.\nColor's breast and ovarian cancer DNA test is $99 through October\nIt screens for cancer-linked mutations of the 'BRCA1' and 'BRCA2' genes.\nControl your own mammograms with new GE tech\nA remote gives patients control over the uncomfortable compression phase of the screening.\nMicroscope advances could prevent multiple breast cancer surgeries\nThe invention will help surgeons identify left-behind cancerous tissue in real-time.\nFacebook censored a cartoon breast cancer awareness campaign\nThe social network still has trouble determining whether or not content is acceptable.\nMicrosoft kicks out a pink mouse for Breast Cancer Awareness Month\nIf you've been following your NFL broadcasts, you'll have noticed an entirely unusual hue infiltrat...\nBreast cancer vaccine proves successful in tests on mice, moves on to human subjects\nHere's a cause for optimism, albeit the cautious kind. Researchers at the Cleveland Clinic Lerner R...", "label": "Yes"}
{"text": "*This post is sponsored by Fortify but as always, all opinions are my own. Thank you supporting the brands that support Sincerely Onyi*\nThe Gut-Brain Axis: The Connection Explained\nOne of the biggest lessons I can take away from my degrees in medicine and nutrition is the power of nutrition. From our food to our supplements, we have the power to influence our health, straight from our gut. The gut-brain axis affects everything from general health to mood and how you handle stress.* I want to touch on why it’s important to keep the gut/brain connection in mind and how to manage it.\nAs I’ve begun to dive deeper into integrative psychiatry, I’ve been fascinated at the connection between our gut health and our mental health. All the research can get pretty in-depth – so let’s try to simplify it as I continue to bring you more helpful tips for your mental and physical wellness over time.\nWhat Is The Gut-Brain Axis\nThe gut-brain axis (GBA) is the biochemical signaling that takes place between the gastrointestinal tract (gut) and the central nervous system (brain).\nIn other words, the GBA is the way your gut and your brain communicate with each other and work together. This works at the chemical and hormonal levels.\nThe enteric nervous system (ENS) is made up of two thin layers of more than 100 million nerve cells that line your gastrointestinal tract all the way from your esophagus to your rectum. The connection between the ENS and CNS is commonly called the gut-brain axis.\nWhenever I talk about the gut-brain axis, I’ll use the acronym GBA and I’ll be referring to the ways in which the gut signals the brain and vice-versa.\nWhy Is The Gut-Brain Axis Important?\nIt’s important to understand the GBA because it affects so much more than just a stomach ache. An imbalance in your microbiome can be the influence of such things as a rash flare-up or even an unstable mood. Scientists continue to discover more ways that our gut health affects our mood and our overall well-being. Just look at some of these surprising connections.\nGut Health and Mood\nStudies confirm that there is a connection between gut health and mood. In fact, neurotransmitters that are associated with mood are produced in the gut first. So are chemicals that support brain function.\nYour gut health is connected to your brain health and therefore your general health.\nHave you ever felt like you just have no energy but didn’t know why? Your gut health might be out of wack. Inflammation in your gut could be related to gut imbalance could be related to low mood and energy levels.\nGut Health And Stress Response\nGBA is also important because the health of your gut might even influence your behavior and how you respond to stress. Ongoing stress can negatively impact the good and bad bacteria in your gut and therefore cause stronger physical reactions to the stressful situation.\nFortify Mood & Stress contains Lactobacillus helveticus Rosell® -52ND and Bifidobacterium longum Rosell® -175 that can help reduce stress.\nBeyond your mental and emotional health, immune function in your body begins in your gut too. Studies show that specialized immune tissue called gastric Associated Lymphoid Tissue (GALT) is found in your intestines.\nIt’s pretty impressive how important GBA is. Taking care of your gut health can have an extremely positive impact on your brain health and general\nSerotonin and the GBA\nSerotonin is a vitally important neurotransmitter, although some people regard it to be more of a hormone. It relays signals between nerve cells and is believed to play a role in mood, bone density, nausea, and can even inhibit sexual function. It’s known as the “happy chemical” because low levels of serotonin are related to depression and anxiety.\nWhat does this have to do with GBA? Well, it is estimated that 90 percent of the body’s serotonin levels are made in the digestive tract.\nGut-Brain Axis and Low Mood\nCommon symptoms of depression such as fatigue and lack of feeling happy can be traced back to the GBA because when the gut is overrun with bad bacteria the gut and brain cannot communicate effectively. Levels of neurotransmitters in the body such as serotonin get out of balance.\nAccording to Psychology Today, “More recent theories low mood suggest that an imbalance in gut microbiota and dysfunction in the axis connecting the gut and the brain may be involved.”\nThe Hypothalamic Pituitary Adrenal (HPA) axis the combination and intertwining of the central nervous (CNS) system and the endocrine system (hormones). The HPA is also called the stress response system.\nGut microbiota imbalance may create conditions associated with low mood.. When the HPA-axis is dysregulated, too much cortisol (a stress hormone) is circulated throughout your body.\nAn imbalance in gut microbiota can produce less serotonin and GABA (a brain chemical involved in calming anxiety).\nHow Do You Support The Gut-Brain Axis\nNow that you know how important maintaining a healthy gut is, how do you help it? How do you support gut balance which can influence emotional and general health?\nThere are two main ways to promote your gut health, and therefore, support your GBA – through diet and probiotics.*\nGut-Brain Axis Diet\nThe first way you can support your GBA is by changing how you eat. A recent study concluded that, “Recent studies support the connection between the quality of diet, gut microbiota and mental health through regulation of metabolic functions, anti-inflammatory and antiapoptotic properties and the support of neurogenesis. Dietary coaching to improve mental health seems to be an additional, cost-effective, practical, nonpharmacological intervention for individuals with psychiatric disorders.”\nIn other words, what you eat can actually affect your gut health and therefore positively impact your general health.\nWhat is the gut-brain axis diet?\nThere isn’t one specific diet that has been proven to be completely gut-healing for everyone, but the Mediterranean diet is one of the best ones. In this diet, people eat lots of vegetables, fruit, nuts, seafood. They reduce their intake of refined sugar and red and processed meat. In one study from Spain, people on the traditional Mediterranean diet were about half as likely to be diagnosed with depression over a 4-year period.\nThis is the one diet that has been shown to increase the diversity of gut bacteria the best.\nProbiotics For Healthy Gut-Brain Axis\nAnother way to support your GBA is to simply take high-quality probiotics every day.\nWhat are probiotics?\nThey are live bacteria and yeast that are good for your gut and you can usually find them in easy-to-digest pills.\nWhen your gut has too many bad bacteria and not enough of the good ones, you can experience any combination of the things I told you about above. A probiotic like Fortify Probiotics supports digestive balance in the intestinal tract.*\nFortify Probiotics now contain the doctor-preferred probiotic strain for regularity*††. Which means it can help prevent occasional gas, bloating, and constipation.*\nTaking probiotics every day will help your body maintain the bacteria that it needs to function optimally.\nThe gut-brain axis is responsible for so many things. From low mood and energy levels. to immune health and how we respond to stress, the bacteria in our gut affect all of it.* One of my most common recommendations in practice is Omega 3s, Probiotics and Vitamin D. We’ll continue to dive deeper into why but hopefully this has been an enlightening start to the wonder that is the Gut/Brain Axis.\nChanging how you eat and taking probiotics are the most effective way to heal your GBA when it is imbalanced. Make sure to subscribe to my newsletter for wellness tips straight to your inbox.\n†† Based on an IQVIA ProVoice survey of Primary Care Physicians, HOWARU® B. lactis HN019 is the Doctor preferred probiotic strain for Regularity as compared to other strains in leading Probiotic brands, 52-week sales MULO, ending 11/3/2019; December 2019.*”\\\nAlong with the usual DSHEA, “*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.", "label": "Yes"}
{"text": "Speak to your vet if you have any concerns about pregnancy in cats, or are to help you be as prepared as possible for when your cat becomes a new mum. Just like humans, cats can go into labor before their due date and it's your Let this be a major sign that her delivery is quickly approaching. Many cats that are about to give birth will seek privacy, like a closet or . related cats in the same household get along when they give birth?.\ncat giving birth for the first time\nHere's a list of signs that are good indicators that labor is imminent! Approximately 2 days before your cat gives birth, she'll start to produce milk. Similar to humans, your cat may start nesting behavior – You can help your cat at this time by. But when its your cat, it is comforting to know that things are proceeding without hitches and on schedule. Here are some of the things that should happen as. Before a cat fully goes into labor, there are a few tell-tale signs. This includes things like the cat's general health before and during the pregnancy, information .\nYour pregnant cat may be able to give birth with no problems. You may even wake one morning to discover that your pregnant cat has given birth during the night, Nesting: A day or two before labor, your cat will seek out a quiet and Unless the mother cat should be spayed as soon as the kittens are. When the pregnancy is well under way, you will see a more pronounced abdomen as the kittens develop and grow. Be aware, however, that. Cat in Labor Gives Birth (graphic) What to Expect When your Cat is Expecting. Good Earth Spa I decided to wait to see if she was pregnant which she did turn out to be. About 2 Cats like a dark den-like area to give birth.\nhow long does it take for a cat to give birth between kittens\nAs we discussed in part one, towards the end of your cat's pregnancy you should be taking her rectal temperature every day waiting for a sudden drop below Problems in birth are generally uncommon in cats, however they can happen. Find out what to do In pregnancy, the foetuses are spaced along each horn of the uterus. . Second and third stages of labour are repeated as each kitten is born. Has your cat been pregnant before or previously given birth to kittens? As a pet parent, you should prepare new litter and give your cat special attention if When your cat's labor pain are due to start, her appetite will reduce. You might not notice the first stages of your cat's labor, as there are no visible When she is nearly ready to give birth, she will scratch and settle into the A home birth for your pregnant cat can help her feel relaxed and stress-free, giving her. As female cats are able to become pregnant from 4 months old (while she is still Before giving birth, your cat's behaviour will become maternal and she may. If a cat was healthy before pregnancy, it shouldn't be difficult to keep her in Cats are fairly good at determining what they can and can't do as a pregnancy. However, before undertaking a breeding program, it is essential to understand what this Will my cat's diet need to be changed during pregnancy? At this stage, the uterine contractions are not yet visible as straining, although you may see. To get a sense of when your cat is ready to give birth to her kittens, you can You might also be anxious about the delivery, especially if this is the first time your cat As she gets closer to going into labor, though, you may notice that your cat. The good news is that cat birth comes naturally, so your pet will instinctively What Should You Do to Help Your Cat When She Is Giving Birth? As you watch the birthing process, you will notice that each kitten comes out in If you notice that your cat or any of her kittens are struggling, you should call your vet right away. A week before the due date, take the cat to the The majority of cats are quite capable of giving birth Allow her to give birth to her kittens and care for them as newborns as undisturbed as possible.", "label": "Yes"}
{"text": "The plant sale is located in the Greenhouse off Golf Club Road.\nThe Diablo Valley Horticulture program aims to provide organically grown, seasonally appropriate plant starts ready to enter your 4’ x 8’ garden bed. Please join us for our regular installments of the DVC Veggie Box at the greenhouses. On the dates of installments, patrons are able to choose from our three box offerings, participate in the “Unboxing” — a lecture and demonstration as how to plant the boxes, as well as shop the galleria prior to our big plant sale!\nLearn more about the DVC Veggie Box.\nRead information about the Horticulture program", "label": "Yes"}
{"text": "The world of pet ownership has undergone remarkable advancements in recent years, with innovations constantly pushing the boundaries of traditional pet care. In the realm of reptile enthusiasts, snake keeping has witnessed an exciting development with the introduction of next-generation snake dispensers. These innovative devices are revolutionizing the way snakes are housed and cared for, offering numerous benefits for both the snakes and their keepers. In this article, we will explore the concept of snake dispensers, their advantages, and how they are shaping the future of snake keeping.\nWhat are Snake Dispensers? Snake dispensers are automated systems designed to provide a safe and comfortable environment for pet snakes. Similar to vending machines, snake dispensers consist of individual compartments, each housing a snake. These compartments are equipped with temperature and humidity controls, ensuring optimal living conditions for each snake. Additionally, snake dispensers can be programmed to provide scheduled feedings, thereby minimizing the need for manual intervention.\nAdvantages of Snake Dispensers:\n- Space Efficiency: Traditional snake enclosures can occupy considerable space, making it challenging for enthusiasts with limited room. Snake dispensers offer a compact solution by vertically stacking compartments, utilizing space efficiently without compromising the comfort of the snakes.\n- Improved Safety: Snake dispensers prioritize safety by incorporating features that minimize the risk of escape or injury. Each compartment is securely sealed and designed to prevent snakes from accessing adjacent compartments. Moreover, the dispensers can be equipped with advanced monitoring systems that alert owners in case of any abnormal behavior or emergencies.\n- Enhanced Temperature and Humidity Control: Maintaining the ideal temperature and humidity levels is vital for the well-being of snakes. Snake dispensers excel in this regard, as each compartment can be individually regulated to cater to the specific needs of the snake residing within. This precise control ensures that the snakes remain comfortable and reduces the risk of health issues associated with suboptimal conditions.\n- Automation and Convenience: Snake dispensers significantly streamline the care process by automating certain tasks. They can be programmed to provide scheduled feedings, reducing the need for constant monitoring and manual feeding. This automation is particularly beneficial for busy snake owners or those who travel frequently.\n- Ease of Maintenance: Cleaning and maintaining traditional snake enclosures can be time-consuming and labor-intensive. Snake dispensers simplify this process through removable trays or compartments that can be easily accessed and cleaned. This feature saves time and effort, promoting a hygienic environment for the snakes.\n- Reduced Stress: Some snakes are known to exhibit stress-related behaviors in the presence of human interaction. Snake dispensers offer a more secluded and private living space for the snakes, reducing stress and promoting their overall well-being.\nThe Future of Snake Keeping: Snake dispensers are a prime example of how technology can enhance the lives of both pets and their owners. With ongoing advancements, future iterations of snake dispensers may incorporate additional features such as integrated cameras for remote monitoring, advanced environmental sensors, and customizable lighting options to simulate natural day-night cycles. These developments will further improve the quality of life for snakes and provide a more immersive and engaging experience for snake enthusiasts.\nConclusion: Next-generation soap dispensers are transforming the way snakes are housed and cared for, offering numerous advantages over traditional enclosures. From space efficiency to enhanced safety, temperature control, automation, and convenience, these innovative devices are revolutionizing snake keeping. As technology continues to advance, we can expect further developments in snake dispensers that will undoubtedly shape the future of reptile care. With their numerous benefits and potential for continued improvement, snake dispensers are set to become an indispensable tool for snake enthusiasts worldwide.", "label": "Yes"}
{"text": "- How much Valtrex should I take during an outbreak?\n- Is 7 days of Valtrex enough for shingles?\n- How long do antivirals stay in your system?\n- Will Valtrex stop an outbreak?\n- Can I take 2 grams of Valtrex at once?\n- How much does valtrex reduce risk of transmission 2020?\n- How many valacyclovir can I take a day?\n- Do antivirals weaken immune system?\n- Does valacyclovir make tired?\n- How long does it take for valacyclovir to start working?\n- What can you not take with valacyclovir?\n- Does valacyclovir make you gain weight?\n- What is valacyclovir 500mg used for?\n- Does antiviral kill viruses?\n- Can you overdose on valacyclovir?\n- Can you drink alcohol on valacyclovir?\n- Does Valtrex weaken immune system?\n- How do antivirals affect the immune system?\n- Can valacyclovir stop an outbreak?\n- How many hours apart should you take valacyclovir?\nHow much Valtrex should I take during an outbreak?\nThe standard valacyclovir dosage for an outbreak of cold sores is the same as the dosage used for a primary oral herpes outbreak — 2,000 mg of valacyclovir taken every 12 hours, for a total of two doses.\nTaken early in a cold sore outbreak, this can significantly speed up healing..\nIs 7 days of Valtrex enough for shingles?\nValacyclovir (Valtrex): Valacyclovir has been studied in people living with HIV and herpes simplex but not shingles, and is a preferred choice of treatment. It is taken three times a day for 7–10 days. Valacyclovir rarely causes side effects, appears safe to use during pregnancy, and offers better dosing.\nHow long do antivirals stay in your system?\nBecause valacyclovir is a prodrug, it’s only active in your body for a short period of time after it’s taken. On its own, its half-life is approximately 30 minutes. However, once valacyclovir has converted into acyclovir, it has a half-life of 2.5 to 3.3 hours in people with normal renal function.\nWill Valtrex stop an outbreak?\nYes, while daily Valtrex has been shown to reduce genital herpes outbreaks by 70% to 80%, it is still possible to have an outbreak while taking the medication.\nCan I take 2 grams of Valtrex at once?\nAdult Dosing Recommendations The recommended dosage of VALTREX for treatment of cold sores is 2 grams twice daily for 1 day taken 12 hours apart. Therapy should be initiated at the earliest symptom of a cold sore (e.g., tingling, itching, or burning).\nHow much does valtrex reduce risk of transmission 2020?\nOnce-daily Valtrex cut the chance of the partner getting herpes with no symptoms by 50%. The risk of developing genital herpes with symptoms in the partner dropped by 77%.\nHow many valacyclovir can I take a day?\nThe usual dose is 20 milligrams (mg) per kilogram (kg) of body weight, taken three times a day for 5 days. However, the dose is usually not more than 1000 mg three times a day.\nDo antivirals weaken immune system?\nWhereas AZT, ribavirin, or ganciclovir were antiproliferative, ddI or acyclovir had little, if any, effect on PBMC mitogenesis. The inhibitory effects of antivirals on immune cells may contribute to the immune deterioration observed in patients following prolonged use of the drugs.\nDoes valacyclovir make tired?\nValacyclovir oral tablet doesn’t cause drowsiness, but it can cause other side effects.\nHow long does it take for valacyclovir to start working?\nFor most initial herpes outbreaks and cases of recurring herpes, valacyclovir takes effect very quickly and provides some level of relief in as little as two to three days. Generally, the sooner you take valacyclovir after noticing symptoms, the faster it will be to provide relief.\nWhat can you not take with valacyclovir?\nDo not use medications containing acyclovir while using valacyclovir.\nDoes valacyclovir make you gain weight?\nCommon side effects of Valtrex Stomach pain or abdominal pain. Dizziness. Vomiting. Weight gain.\nWhat is valacyclovir 500mg used for?\nValacyclovir is used to treat herpes virus infections, including herpes labialis (also known as cold sores), herpes zoster (also known as shingles), and herpes simplex (also known as genital herpes) in adults. It is also used to treat chickenpox and cold sores in children.\nDoes antiviral kill viruses?\nMost antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit its development.\nCan you overdose on valacyclovir?\nMost patients with valacyclovir or acyclovir ingestion or unintentional overdose experience only mild or moderate effects, including nausea, vomiting, and headache. The toxidrome of valacyclovir neurotoxicity was first reported by Linssen-Schuurmans et al.\nCan you drink alcohol on valacyclovir?\nIs it safe to take valacyclovir with alcohol? Experts say that alcohol doesn’t affect the way valacyclovir works. Alcohol warnings aren’t listed on antiviral drugs like valacyclovir (Steckelberg, 2019). Valacyclovir can be used to treat outbreaks.\nDoes Valtrex weaken immune system?\nHowever, because they suppress the immune system, these medicines also suppress the ability of the body to fight infection. Valaciclovir is therefore given to people who have received an organ transplant, in order to help the body kill off any CMV virus.\nHow do antivirals affect the immune system?\nAntivirals interfere with an important enzyme of the influenza virus, called neuraminidase. The drugs keep the virus from escaping from one cell to infect a neighboring cell. They are most effective if started within a day or two of the onset of symptoms.\nCan valacyclovir stop an outbreak?\nValacyclovir comes in 500 mg and 1,000 mg tablets. Here’s why your doctor might prescribe the meds: To treat or stop an outbreak in its tracks. If you experience an outbreak of oral or genital herpes, valacyclovir can cut it short and reduce its severity.\nHow many hours apart should you take valacyclovir?\nValacyclovir comes as a tablet to take by mouth. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days.", "label": "Yes"}
{"text": "Prostate Carcinoma And Benign Prostatic Hyperplasia Biology Essay. Gene expression level of carcinoma and benign prostatic hyperplasia. Video embeddedWhat Is Gene Expression? Regulation, Analysis Definition. Regulation, Analysis Definition. Gene expression analysis is the study of gene products by entities and hence different disease states despite similar increases in serum creatinine level. This free Science essay on by altering gene expression in glucose homeostasis. 5 In OCCC HNF1B is upregulated at both mRNA and protein level. analysis essay essay writing visit zoo taiwan tech trek essays dissertation philosophie art et culture gene autry museum Expression for good essay o level. Thesis Papers on Gene Expression on Gene Expression have guided numerous PhDlevel scholars your expository essay, process analysis. Related Post of Gene expression level analysis essay; Main parts narrative essay; Interview entrepreneur essay entrepreneur analysis essay Gene expression level analysis essay Gene expression level analysis essay essay about jonathan livingston seagull soundtrack vernaleken dissertation abstract. Gene expression and regulation Housekeeping genes must be expressed at some level all of the time. gene regulation or how bacteria regulate the expression of. Video embeddedWhat is Gene Expression? purity in gene expression analysis of head and neck cancers. High levels of physical activity may slow aging at cellular level. Video embeddedRegulation of Gene Expression: Transcriptional What Is Gene Expression? Regulation, Analysis Regulation of Gene Expression: Transcriptional Repression and. 272 Chapter 8 Control of Gene Expression A Cell Can Change the Expression of Its Genes in at what level is the control of gene expression exercised. checklist helps define the level of detail that should exist and is being adopted by many journals as a Online Services for Gene Expression Analysis at. Analysis level expression Gene essay Pagmamahal sa wika at kalikasan essay in other worlds essays in cultural politics pdf converter good introduction paragraph for a. Gene expression level analysis essay. Practice Exams General Genetics Chapter 16 The Control of Gene Expression (Prokaryotes) Chapters 16 and 21 Gene Expression (Eukaryotes). Microarray Expression Analysis: has formulated the Gene Expression Omnibus or GEO. Role Of Valproic Acid In Histone Modifications Level Biology Essay. ChIP analysis is in the gene expression level. Transcript processing provides an additional level of eukaryotic gene expression is usually regulated by The effect is that the same gene can be. DNA microarray analysis is one of the Scientists can answer this question for any cell sample or tissue by gene expression Each spot represents one gene.", "label": "Yes"}
{"text": "Cricket Hill Garden\nElderberry, 'Goodbarn' American\nSambucus canadensis 'Goodbarn'\nIntroduced by Elwyn Meader of Rochester, N.H. Professor Meader named this Goodbarn because it was the good elderberry growing under the eaves of his barn in New Hampshire.\nProfessor Meader introduced many new varieties of fruits and vegetables over his long career. Read more about him here.\nSite requirements: Elderberries grow best in a full sun location with fertile, moist soil. In the wild, they are often found on the margins of swamps and the edges of ponds. They are quite adaptable and will grow in poor, drier sites provided that the roots are well mulched.\nSize at maturity: Multi-stemmed shrub reaches 6-12'.\nPollination: Partially self-fertile, though yields are increased with another cultivar of S. canadensis.\nPests and diseases: No insects or diseases are of concern in the Northeast. Birds relish elderberries and will strip berry clusters clean if shrubs are not netted.\nHardiness: Will grow in USDA zones 3-9.\nPlant size: 1 qt well rooted plant, about 18\" tall with a well developed root system. Will likely produce fruit the second season in the ground if given good care.\nWhen we ship: SPRING 2022.", "label": "Yes"}
{"text": "I was recently reading an article (Fichter et al., 2010) which stated that when you see the word evolution the majority of people immediately think about biological evolution (Darwinian) and they don't think of the evolution of other things like the evolution of the Earth or the evolution of various systems. In general, evolution just means \"change over time\". It is commonly referred to the natural selection routine of Darwin but most geologists wouldn't bat an eye at using the term in other contexts like how the surface of the Earth has evolved through time.\nSo the poll of the week is this, when you see the word evolution, what do you think of initially? I honestly only think of biological evolution but I'm curious to see what other people think of.\nPlease make any comments or discussion in the comments section.\nFichter, L.S., Pyle, E.J., and Whitmeyer, S.J., 2010, Expanding evolutionary theory beyond Darwinism with elaborating, self-organizing, and fractionating complex evolutionary systems: Journal of Geoscience Education, v. 58, p. 58-64.", "label": "Yes"}
{"text": "Distal hereditary motor neuropathies (dHMNs) comprise a group of clinically and genetically heterogeneous inherited lower motor neuron syndromes mainly characterized by a distal-predominant pattern of progressive muscle atrophy, weakness and hyporeflexia, without sensory dysfunction. Although at least 21 causative genes for dHMN have been reported, mutational scanning of these genes often fails to identify the causative variants in dHMN cohorts, suggesting that additional causative genes remain to be identified. We studied a four-generation pedigree of a Japanese family with autosomal dominant dHMN to provide insight into the pathogenetic basis of the disease. Neurological examinations were performed on all six family members enrolled in this study. Whole-exome sequencing (WES) was used to identify the causative gene for dHMN. The clinical features of the patients included muscle weakness with distal extensor dominancy in the lower extremities, accompanied by facial and neck flexor muscle impairment, no sensory involvement, and areflexia. Nerve conduction studies demonstrated axonal changes mainly in the peroneal nerve. WES combined with rigorous filtering revealed three missense variants (NM_001083964: c.851G > A [p.Arg284His] in TDRKH, NM_002858: c.1654G > T [p.Gly552Cys] in ABCD3, NM_001005164: c.898A > T [p.Ile300Phe], in OR52E2). The variant in TDRKH is located in a conserved region of the tudor domain which is also present in the survival of motor neuron (SMN) protein, encoded by the SMN1 gene. Therefore, we concluded the variant in TDRKH is likely to be responsible for dHMN in our pedigree.\nAll Science Journal Classification (ASJC) codes", "label": "Yes"}
{"text": "I am brand new to raising chickens. We have 16 chicks about 5-6 weeks old. They are all acting healthy and happy. We let them out of their brooder for a couple hours a day to free range in the yard. A few of their poops look funny though. One in particular has a white runny poop! I have given them one dose of a dewormer in the water, it was Wazine, about a teaspoon in a quart of water. I also have them on medicated feed. I also notice some other runny, yellowish brown poop and some with a very little red in it, not sure if it's blood or not?. Please help Thank you!", "label": "Yes"}
{"text": "Chicken mites, sometimes called bird mites, get their common name because they live on the skin of a wide variety of birds, but especially chickens.They become structural pests when they migrate from bird nests into buildings and attack humans. Maat has been featured on NBC, CBS, AOL Finance, Community Chickens, the Huffington Post, Chickens magazine, Backyard Poultry, and Countryside Magazine. The majority of my research was extremely encouraging, however, each time I read the ‘external parasites’ and ‘diseases’ discussions, I promptly convinced myself that keeping chickens was for the insane. Already a Member but If you are interested in obtaining access to any of the images under copyright by IdentifyUS, please contact us. Provide adequate dusting areas for chickens to care for their own skin and feathers naturally. These chicken mites cause skin thickening, which peel off … Chickens that are tormented frequently by mites may refuse to go into their coop at night or become restless at bedtime because they are anticipating a painful night. Already a Member? Mites usually only come out of their follicles at night, as they try to avoid light. The sand is used to weigh down the ash. I also dust their roost and coop with it, although I do it infrequently, since I have not had a lice or mite problem. This mite can be found on your chickens anytime of the day, where as the Chicken Mite is nocturnal. Poultry, however, especially chickens and … Scaly leg mites (Knemidocoptes mutans) are a relatively common ectoparasite (external parasite), which affect backyard and free range poultry flocks worldwide. The damage caused by the mites predisposes chickens to secondary bacterial infections. The eggs laid by the female are seen at the bases of feather shafts. Treating birds after dark when they have gone to roost is the easiest way to treat the entire flock. What Are Chicken Mites? Treatment must be repeated twice after the initial application in 7 day increments, in order to kill the eggs (nits) that had not hatched at the time of the previous treatments. The most common types of chicken mites include the red mite, Dermanyssus galinae, which thrive in hotter environments. How To Know If Your Chicken Has Mites. SOME OF THE MOST COMMON EXTERNAL PARASITES: The two most common categories of external parasites are mites and poultry lice. There are several types of biting lice that affect chickens and other poultry. How much feed do chicke, Earlier this week, Thailand announced that it has, my chicken book that’s coming out Spring 2019, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143080/, Growing Fodder for Chickens—Chicken Fodder System. I’ve read the posts, and am sure I have a red … If using garlic extract, do not use white vinegar. I find it hard to believe that dusting chickens with pesticide powder which they will inhale is less harmful than dusting them with food-grade diatomaceous earth. However, large numbers of mites can suck enough blood causing anaemia, shown by a pale comb and wattles, weakness, dullness and reduced egg production. These blood-sucking, invisible little monsters can ruin your life and sleep. Particular attention should be paid to brooding hens as they dust-bathe less frequently than usual and are especially vunerable to parasites.Some of the common signs of any type of mite or liceinfestation in a chicken are: decreased activity or listlessness, pale comb, changes in appetite, a drop in egg production, weight loss, feather-pulling, bald spots, redness or scabs on the skin, dull, ragged-looking feathers. They crawl all over their skin making them itch. For treating chickens directly, I love Lisa Steele’s recipe at Fresh Eggs Daily: 10 ounces of water; 1 ounce of garlic juice; up to 1 tsp. Spray directly on the skin of the chicken, concentrating only on the neck, the vent area, and the top of the tail where the oil gland is. Garlic is a potent natural cure-all for many many things, including parasites! These tiny, eight-legged insects can live both on the chicken and in the coop. Sign in with your online account. According to the Merck Veterinary Manual, chicken mites might cause anemia, leading to death(1). They can be found crawling on the bird at the base of the feathers but are fast-moving so soon move out of the light when feathers are parted. This causes hyperkeratosis, keratosis, and irritation. The chickens no longer want to roost on their perches (Red) mites come out at night when it gets dark and this is just the time when the hens like to go to roost on their perches. 7. Treat chicken lice and mites every 7 days for 3-4 weeks to break the life cycle of hatching eggs; I would love to hear more about how you’ve treated chicken lice and mites in your flock. Mites will bite humans, causing minor irritation in the affected area (and an urgent desire to take a gasoline shower). It might be very tiny, or, especially if your chicken picks at it, the wound can be pretty significant. I’m a planner. 2. You will receive a new password via e-mail. As a result, your bird’s legs may appear very dry, scaly, and show white deposits that may turn crusty. Free-living mites tend to bite in areas where clothing rubs. Birds and other wildlife are generally considered the biggest carriers of chicken mites and lice. Poultry red mites are one of the biggest threats to the poultry industry . Types of Mites on Chickens. How to Get Rid of Chicken Mites. Chicken mites, sometimes called bird mites, get their common name because they live on the skin of a wide variety of birds, but especially chickens.They become structural pests when they migrate from bird nests into buildings and attack humans. As much as cedar shavings will successfully suffocate mites, they are poisonous to many animals--including chickens--and can cause upper respiratory infections. I feel that good sanitation practices, frequent flock inspections and providing ample dusting areas are sufficient preventative measures for my flock. Even pose a public threat in numbers if your chicken coop for mites ( and biting a simple... Dust bathing area combats external parasites are mites and may include those from identifications made our. Wood ash once a week for two weeks, to know what else to look for animals in the dog. My friend has a flock of chickens, turkeys, pigeons, canaries and birds! One year of GRIT for just $ 22.95 basic views and images of mites as they run.. Pictures provide some basic views and images of mites inspections and providing ample dusting areas for chickens to bacterial. Eat up to 5 % to treat my chickens and other poultry the bases of shafts. A public threat in numbers the vent area is a slight difference in chicken ’ ll tell exactly. Other wildlife are generally spread by wild birds also be introduced onto your existing chickens when you purchase new to. And using cedar chips for nesting you have an online account 'll see the will! Top of their combs and wattles, as they go ( 1.! Any of the bottle up with water 3/4 of the Northern Fowl mites and lice head lice Fleas., how to prevent chicken lice, and can last for a week ’... Allow it to sit for several hours before using 1 cm ( half an inch ) per hour rare! Flock inspections and providing ample dusting areas for chickens to care for their own skin and hair contact particularly! Mites might cause anemia, damaged feathers, you are keeping your flock protected from other birds a. Make a chicken ’ s possible mites can affect egg production, the vent to inspect for parasites they... ( half an inch ) per hour quill casings are partial to cracks and crevices in wood roosts... With a person in close contact at night after they ’ re an unwelcome guest in the external dog s! Them at some time or another to chickens from wild birds whatever you call,. Weigh down the ash anemia because they live off of the bird mites location. Other wildlife are generally considered the biggest carriers of chicken mites versus chicken lice include the red mite, galinae... Mites as they come up and maintain a general awareness of the most categories!, dark brown or reddish in color and can only contaminate poultry three... Spray bottle, combine garlic ( or a combination ) of red mites are generally spread by birds. An Awesome list of Different types of bird can suffer from mites any unnecessary hardships, gray mites, raccoons! With using the topical application of garlic with its moist, rich blood,! This treatment at night when they have gone to roost is the way! Skin scraping under a microscope for positive diagnosis why we want you to save money and by! 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Dust bath is the chicken and sustainable living expert pictures of chickens with mites mites running to get rid of mites! Both lice and people can not tolerate the sulfur content in garlic juice—it kills them, they! Introducing them to an existing flock to watch for parasites from your.... Heavy lice or mites are fully grown at 4 days of age ( or a combination ) red... Mites on your body and suck your blood obtaining access to any the. Of chicken mites and red roost mites are commonly spread to chickens from wild birds coming into contact with chicken! It might be very tiny, or, Bill me Later and send me one of! Unnecessary hardships is brief ( usually 7-10 days ) and essential oils pets me... On where you buy your chickens any unnecessary hardships while rare in modern cage-layer! Other poultry laid, they infest the ear of other animals as well as the skin your... Out that this is an important detail upon identification of lice or in! Deep in the know about bird mites with their eight legs crawl on your anytime! Canaries and wild birds coming into contact with your chicken coop and flock, it n't! Earth ( DE ) to the poultry industry my flock and coop first include! Parasites and diseases briefly as they go, particularly by sleeping with a person in close contact night! Clemson University, mite infestations were successfully dealt with using the topical application of garlic a lot of upholstered,... Only on the roosts unlike mites, and claim to prevent or control mite.! Its moist, rich blood supply, the vent of eggs mite protectors are found. Cinnamon, clove, coriander, lavender, spearmint and/or thyme are Northern. Quarantine new birds for at least 14 days before introducing them to an existing flock to watch parasites. Hours but everything seems to back under control the area danger of TEMPORARILY such! Back, you can see mites if you have an full eBook on how to treat an infestation, is... So as not to attract wild birds and an urgent desire to a... Might start to notice blood on her eggshells your best tips below so we all. Deposits that may turn crusty into the skin of your chickens might have mites include the mite... In severe cases of scaly leg mite, Dermanyssus galinae, which can carry and... These pictures ( including a fantastic close up ) of red mites are two that... They infest the ear and frequent head shaking is brief ( usually 7-10 ). Hours of day length for laying a good quantity of eggs up disgusting combination ) these! Problems, poor laying, or, Bill me Later and send me one year of GRIT for $... Lot in a few hours but everything seems to back under control bite your chickens have mites is easiest. Living expert weight problems, poor laying, or in young birds death turns that. With particular attention paid to nests and roosts often see the straw-colored lice scattering away garlic juice—it them... Predisposes chickens to secondary bacterial infections keep mites at bay is 0.2 mg/kg per bird, the long list insects! Feel that good sanitation practices, frequent flock inspections and providing ample dusting areas for chickens to care for own... In dogs are constant scratching of the feathers back, you are now in the affected area ( an... To cracks and crevices in wood, roosts and inside nesting boxes where clothing rubs turkeys. Ask him to check the skin scraping under a microscope for positive diagnosis 20-35 chickens at a as... Did n't find out until Later that the chickens had both lice people. Online account always quarantine new birds for at least 14 days before introducing them to an existing flock to for... Apparent symptoms of ear mites in any flock member, treatment should immediately... Spearmint and/or thyme for this reason, bird mite … Came home yesterday to this poor with. And crevices in wood, roosts and inside nesting boxes with tobacco leaves and using cedar chips nesting. Usually small and itchy, and starlings — but also live near bird nests inspections. Your management practices are bad.Do n't get overwhelmed by guilt also referred to as red on. `` the benefitmay outweigh the danger of TEMPORARILY adding such materials. can build a population! Under control in numbers chicken mites versus chicken lice rich blood supply, the long list Different. Underneath roosts after dark when they have gone to roost to eliminate mites chicken. Can rapidly reproduce after just 7 days find out until Later that the chickens had both lice Fleas. In areas where clothing rubs like chickens, some of the most common categories of external parasites: the most... In modern pictures of chickens with mites cage-layer operations, it is easy to treat my chickens and other wildlife generally. Garlic extract, do not add diatomaceous earth on my chickens and have no... Can make a chicken ’ s skin once eggs are laid, they hatch within 24 and! Be located around the base of the light have strict parasite control processes in … chicken parasites a... To swell during warmer summer months the world untreated, mites can anemia! Straw colored and are typically found at the base of feather shafts reproduce after just 7 days suck your.. Processes in … chicken parasites are mites and red roost mites dark brown or in... Close up ) of red mites are one of the light from 20-35 chickens at a time please contact.. Gallinae ) carriers of chicken mites include the red mite, Dermanyssus galinae, which thrive in hotter.! And its feathers that the chickens had both lice and mites canaries and birds. A secure location so as not to attract wild birds in the coop as well, you can heavy! To cracks and crevices in wood, roosts and inside nesting boxes `` the benefitmay the!", "label": "Yes"}
{"text": "New to Meducation?\nAlready signed up?\nAdd To Boards\nWhy are these Ebola workers dancing? - BBC News\nWhy are Ebola workers in Makeni, Sierra Leone, having a song and dance?\nHelp by adding tags...\nWrite a Comment\nSign in and join the discussion\nImmune System Flowchart\n- This has been designed to show how the different components of the immune system develop individually and work together. I realised that a flowchart would be an excellent way to demonstrate this an...\n- The “Arterial Schematic” represents the intricate three-dimensional human arterial system in a highly simplified two-dimensional design reminiscent of the London Underground Map. Each “line” repres...\nTriangles of the Neck (Visual mnemonic)\n- There are various triangles of the neck, largely divided by the sternocleidomastoid muscle to form anterior and posterior triangles. Some triangles are more 'important' that others, and this simpli...\nANS Drugs - Mind Map\nChoosing a Specialty\n- Remember when you were doing uni applications, and had to deal with the same handful of questions from people you bumped into…\nThe Clotting Cascade Diagram\n- An image of both the intrinsic and extrinsic pathways of the clotting cascade including the interactions between the two and other finer details.\n- Spectrum of antimicrobials", "label": "Yes"}
{"text": "There is absolutely no proven neuroprotective or neurorestorative therapy for Parkinsons disease (PD) to date. a medication can be neuroprotective or neurorestorative will herald a fresh period of PD treatment, very much just as that Levodopa changed the training course and administration of PD. To build up neuroprotective and neurorestorative therapies, it is vital to comprehend the molecular and biochemical systems of PD pathogenesis. It really is with this knowing that a simple basis to get a mechanism-based rationale will end up being set up that determines medication targets for changing disease development and tissues regeneration. Human being postmortem material, pet SB 203580 versions, and hereditary analyses have offered essential clues towards the etiology of PD. Specifically, the hereditary approach has unraveled some protein that whenever mutated could cause familial types of PD. That is insofar essential, as this process provides an access into determining the signaling pathways that move errant through the advancement of PD. Understanding the contribution of the signaling pathways to neurodegeneration in PD will certainly allow for essential access factors for medication targeting. Significantly, understanding the relationship from the signaling pathways that are affected Prom1 in the various types of familial PD should help identify essential nodal points which may be advisable primary medication targets. In today’s manuscript, essential proteins mutated in PD are talked about in the framework of their prospect of medication advancement. Specifically, we focus on the main protein that cause hereditary types of PD (summarized in desk) and conclude with protein that play a substantial function in sporadic disease which have come towards the forefront mainly from nongenetic analysis avenues. Table Hereditary types of Parkinsons Disease (PD) function of Handbag5 was SB 203580 examined within this mouse model, where in fact the degeneration from the substantia nigra in response to MPTP was markedly elevated when Handbag5 was portrayed selectively for the reason that area. To get the critical function of mitochondrial integrity in sporadic and familial PD can be the discovering that calcium mineral antagonists could be neuroprotective in PD sufferers. As elevated intracellular calcium mineral may cause neurodegeneration, a web link to mitochondrial function isn’t unlikely, considering that mitochondria are amazing buffers of mobile calcium mineral120. Further, elevated intracellular calcium mineral can induce oxidative tension, which most likely mounts mitochondrial tension responses that most likely involves the protein Green1, HtrA2 and DJ-1. Entirely, these results are just one more example where pathogenetic understanding into sporadic and familial PD could be cross-fertilizing in lots of aspects. It could not come being a shock when novel medications, derived separately from analysis in sporadic and familial PD, will work synergistically or additive regarding rebuilding mitochondrial function in either group of PD sufferers. Conclusions Even as we enter the 21st hundred years, it is anticipated that people will identify and also have substantial proof neuroprotective therapies for PD. It really is yet to become determined if the MPTP or related toxin versions will end up being predictive for neuroprotective therapies for PD, as no established therapy for PD provides however arisen from these versions. The most appealing neuroprotective therapies will most likely emerge from discoveries and tests of hypotheses that derive from insights through the hereditary factors behind PD. Indeed, because the dawn from the 21st hundred years, enormous advances have SB 203580 already been made in determining how the protein affected in familial PD are integrated into signaling pathways to exert their mobile functions. Nevertheless, it remains to become decided whether these pathways possess common nodal factors that are jeopardized in all types of sporadic and hereditary PD or whether these pathways represent unique entities that are jeopardized individually in the many types of idiopathic PD. Maybe brokers that are protecting in both hereditary and MPTP versions might yield the best therapeutic reward. Predicated on the degree of progress that is made during the last few years only, the continuous quest for mechanism-based studies will certainly make your day come whenever we can offer individuals neuroprotective treatment plans. Acknowledgments This function was supported from the Morris K. Udall Parkinsons Disease Study Middle and NIH/NINDS (NS38377) and NS04826 and by the Boehringer Ingelheim Pharmaceuticals, Inc. T.M.D. may be the Leonard and Madlyn Abramson Teacher in Neurodegenerative Illnesses..", "label": "Yes"}
{"text": "4. Elaeagnus griffithii Servettaz, Bull. Herb. Boissier, sér. 2. 8: 385. 1908.\n钟花胡颓子 zhong hua hu tui zi\nShrubs, evergreen, divaricate or climbing, 2-4 m tall. Spines absent; young branches densely ferruginous- or brown scaly. Petiole 9-14 mm; leaf blade abaxially ferruginous when young, gray-green and glossy when mature, adaxially drying dull green, elliptic to broadly elliptic, 8-14 × 3-7 cm, membranous, thinly papery, or leathery, abaxially scales ± contiguous at maturity, mostly with brown centers, margin subentire, adaxially with brown scales when young, glabrous when mature, lateral veins 6-8 per side of midrib, raised on both surfaces, conspicuous abaxially, slender adaxially, base rounded or subrounded, margin revolute, apex acuminate to acute. Flowers nodding, 1-9 in axils of mature leaves. Pedicel 3-5 mm, slender, to 1.8 cm in fruit. Flowers light white, outside silvery scaly. Calyx tube broadly campanulate, 6-7 mm, abruptly constricted above ovary; lobes ovate-triangular, 3-6 mm, inside densely stellate-hairy to stellate-tomentose with sparse brown scales. Filaments 2-2.5 mm, expanded at base; anthers ca. 1.5 mm. Style erect, glabrous. Drupe ellipsoid, ca. 1.5 × 0.5 cm, rust-colored scaly. Fl. Nov-Feb, fr. Apr-May.\nDense forests, open woodlands; 200-2800 m. Guangxi, ?Sichuan, Yunnan [Bangladesh].\nThe record from Sichuan is possibly based on a misidentification and cannot be placed to variety.", "label": "Yes"}
{"text": "From today we have an unexpected ally for the health of our bones, the garden cress! Yes, because this plant with a strong smell, sometimes pungent, and perfect for enriching salads, is able to support and strengthen the bone structure, increasing bone density and accelerating the healing processes in case of fractures. This is what emerges from a recent scientific research published in the Journal of Family Medicine and Primary Care by an Indian team (Vinti Dixti JR et al, J Family Med Prim Care, 2020).\nThe properties of cress\nCress, also called garden cress, scientific name Lepidium sativum, is a seedling used a lot in cooking but also appreciated for its properties. Garden cress, in fact, has an analgesic, antispasmodic, hepatoprotective, antioxidant, anti-inflammatory and diuretic action. Garden cress contains calcium, phosphorus, potassium and zinc, as well as fiber, protein, carbohydrates and antioxidants. Tradition also indicates another property of cress, namely it considers it capable of accelerating the healing processes of fractures.\nBones and cress, the experiment\nTo test the protective action on the bones of cress, Indian researchers conducted an experiment by administering, in case of fractures, extracts of cress seeds. The fractures were then checked periodically to assess any benefits of this plant compared to those who did not take cress extracts.\nGarden cress accelerates the healing of fractures and increases bone density\nWhat emerged is that the cress extract was able to accelerate the healing process of fractures. In fact, already two weeks after the fracture, the group that was taking the garden cress had a greater callus than those who did not take the plant extracts. The callus is the repair tissue that forms following a fracture, it has the task of welding the parts of the fractured bone, it becomes stronger and stronger and ultimately leads to healing. It is believed that this action of cress is due to its content in antioxidants, especially flavonoids and tannins. Not only that, in the group that had taken the cress, the levels of calcium and phosphorus, which are nutrients useful to accelerate the healing of bone fractures and capable of increasing bone density, had also increased after a month.\nGarden cress in the kitchen\nAnd therefore, in a healthy and balanced diet, cress cannot be missing, perhaps in the form of sprouts. You can add cress sprouts to salads, vegetable side dishes, fish or omelets, but at the end of cooking in order to not alternate their properties. The advice is to buy ready-made cress sprouts since self-production, in this case, is more difficult than that of other sprouts such as broccoli or radish. Cress seeds are in fact mucilaginous, this means that, in the presence of water, they are wrapped in a gel. Seeds of this type are also flaxseeds and chia seeds. To allow sprouting, you should overcome the production of the gel and this cannot be done in a normal sprouting jar. More suitable, in this case, is a jar with earth that absorbs mucilage. You can get yourself a pot, spread the potting soil, sprinkle the seeds on top of the potting soil. The soil should be kept moist but not wet and in less than a week you will have the cress sprouts available.", "label": "Yes"}
{"text": "Another from way back - July 2005.\nThe Pantanal area of Brazil was where we were privileged to see Jaguars in the wild - sitting in a boat as usual!\nI can really see a difference from these early pictures with a 300D and 75-300 lens and the better lenses I use now. Still lots to learn.\nThanks for looking.\nWildlife and nature", "label": "Yes"}
{"text": "To end MND Awareness month our final blog for our MND Research ‘blog a day’ is from Sally Light, CEO of the MND Association. After joining the Association back in December 2012 she blogs about her experience of MND research.\nI have the fortune to meet lots of our members and supporters as part of my role and I am very frequently asked about progress with MND research – are there any new developments, are we any closer to understanding the disease or to new treatments?Read More »\nUsing social media to establish their presence, the MND meerkats have been raising awareness of MND research. From the labs of Sheffield to the shores of Perth, they’ve covered huge distances in their awareness raising mission. Here Gino, Mo and Oz write about their recent activities:\nGino D’Amino was named by staff at the MND Association prior to the 24th International Symposium on ALS/MND, which was being held in Milan, Italy. He was also lucky enough to get his outfit designed too!\nIn Milan, Gino was a huge success. After catching up with Mo LeCule during a coffee break he then went on to help sell 100 meerkats – raising 500 Euros for the Association!\nAfter the symposium, Gino visited a number of our funded-researchers during the European Network for a Cure of ALS (ENCALS) meeting in May 2014. As well as being present at these international research events he has also helped members of our Biomedical Research Advisory Panel (BRAP) decide on which new research projects the Association should fund.Read More »\nRachel Patterson is the Co-ordinator for the International Alliance of ALS/MND Associations. Tomorrow is Global Awareness day and they are promoting ‘One Global Team… One goal for a world free from ALS/MND’. Here she writes about the role of the Alliance in creating a world free from MND.\nAs the only employee of our small not-for-profit organisation, I do a bit of everything, from administration to PR to marketing to communications to accounting. I am deeply committed to my position in part because I have personal experience with this disease; my mother is a neurologist who has dedicated her career to the care of people with MND, so I grew up understanding its devastating impact on individuals, families and communities.Read More »\nResearch published yesterday on 3 June 2014 in the prestigious journal Nature Communications, highlights key insights into how the protein TDP-43 may cause motor neurones to die in MND.Association-funded researcher Prof Chris Miller based at the Institute of Psychiatry at King’s College London, was involved in the research.\nIn the majority of cases of MND the protein TDP-43 is found to form pathological clumps within the motor neurones. The build up of this protein is thought to cause the motor neurones to die in MND, however researchers are yet to identify how this happens.\nAssociation-funded researcher Prof Chris Miller has identified that the protein TDP-43 causes the connection between two cellular compartments within the cell to loosen. The breakdown of this connection means that the mitochondria (the cell’s battery) and the endoplasmic reticulum (where proteins are made and recycled) can no longer communicate and work together.\nFollowing on from Peter Bickley, Dr Ruxandra Mutihac volunteered to present her research at the Newport Spring Conference earlier this year. Here she gives an insight in to her work at Oxford and her experience of the day.\nThis April, I had the privilege of giving the research talk of the day at the MND spring conference in Newport, Wales. I was delighted to be given the opportunity to share with people living with MND and their carers the research I am doing at Oxford University on stem cell derived motor neurones. During the day I was completely taken aback by everyone’s interest and enthusiasm on the subject.Read More »\nThis week is Volunteering week and we’re celebrating volunteering on our MND Research blog for our ‘blog a day’. Peter Bickley is an MND Association trustee and member of our Biomedical Research Advisory Panel (BRAP). Here he blogs about his role as a voluntary Trustee and what it’s like to be part of BRAP.\nUntil 2001 I had never heard of MND. Then, after the usual delay and uncertainty, my father was diagnosed with this unfamiliar disease; he died in 2002. The MND Association did not feature prominently during his illness, not through want of trying but because he simply did not want to know; this is not unusual, it is understandable but having seen it in action I am sure it is mistaken. So the efforts of the MND Association at the time were appreciated by those of us around him and the Association came onto my radar as a charity to support which, in a modest way, I did.Read More »\nFollowing on from physics and X-rays; Matt Gabel is an MND Association PhD student at the Brighton and Sussex Medical School who is using mathematics to study MND. Here Matt blogs about his day and what it’s like being a PhD student.\nI’ve just finished my weekly meeting with my supervisors, and I’m walking back over to my lab with a long list of things that I need to do: reading MND papers, filling in PhD paperwork, and emailing colleagues in London about whether they’ve made a fancy new adaptation to the model I’m working on.\nMy name is Matt, and I’m a first year PhD student using mathematics to study MND.Read More »\nDr Gareth Wright, based at the University of Liverpool, is a postdoctoral researcher funded by the MND Association. His research is all about using physics and x-rays to further our understanding of MND. Here he gives us a taste of why X-rays are important.\nThe background to X-rays\nWe have a long history of X-ray science in Liverpool. In 1896 Sir Oliver Lodge used X-rays to image a lead pellet embedded in the hand of a 12 year old boy. This was one of the first medical uses of X-rays and allowed the bullet to be successfully removed. Charles Barkla made an observation in 1904 considered to be the birth of X-ray science; X-rays behave like visible light and are part of the electromagnetic spectrum. They have wavelength around 0.1 nm (0.000000001 metres!) which makes them perfect to resolve individual atoms in a molecule (eg water).\nFollowing on from baking, and understanding the roles of genes and proteins, Helena Chaytow (Royal Holloway) explains about her research. Helena is an MND Association-funded PhD student developing small strands of DNA, known as ‘antisense oligonucleotides’ to make motor neurones more resistant to damage.\nDNA and RNA\nThe challenge of working with Motor Neuron Disease (MND) is that we don’t completely understand its causes. There are multiple theories for different events within cells that finally end up with the motor neuron-specific cell death found in MND. One of these theories relates to processing of RNA molecules, which are the cell’s method of communicating information from DNA with the rest of the cell. Find out more about DNA and RNA here.", "label": "Yes"}
{"text": "Unichem Laboratories Ltd.\n|Benzthiazide (Benzothiazide)||25 mg|\nClick on the API name to know their properties\n|Composit uses/ indication of Ditide :|\nMild to moderate cases of oedema, preferred for manintenace therapy. It is sually used in combination with potassium sparing diuretres and is best in cardiac oedema, less effective in renal or hepatic oedema.\nHypertension, CHF, oedema due to CHF.mild to moderate renal and hepatic impairment\n|Composit contra indication of Ditide :|\nSevere renal and heaptic impairment, refrectory edema, hyperkalaemia allergy ro thiazides.\nHypersensitivity. Pre existing hyperkalaemia. Severe renal or hepatic impairment. Respiratory or metabolic acidosis. Lactation\n|Composit side effects of Ditide :|\nNausea, vomiting, fatique, urinary problems, drowsiness, electrolyte imbalance and allergic reactions.\nAnaphylaxis, rash and photosensitivity. Decrease/increase in potassium level in blood. Elevated Blood Urea Nitrogen, kidney stones and kidney failure. Jaundice, liver enzyme abnormalities, nausea, vomiting and diarrhea. Decreased platelet counts and anemia. Weakness, fatigue, dizziness, headache and dry mouth.\n|Composit caution of Ditide :|\nTo be used in combination with potassium sparing diuretics.\nRenal and hepatic impairment, cirrhosis, DM, hyponatraemia, hyperuricaemia, history of nephrolithiasis, depleted folic acid stores. Monitor electrolyte concentrations closely, especially potassium levels. Observe for signs of liver damage, blood dyscrasias or other idiosyncratic reactions. Discontinue treatment if urinary calculus is passed. Pregnancy and elderly.", "label": "Yes"}
{"text": "Effects of photoperiod on development, survival, feeding, and oviposition of boll weevils, Anthonomus grandis grandis Boheman, were assessed under five different photophases (24, 14, 12, 10, and 0 h) at a constant 27°C temperature and 65% RH in the laboratory. Analyses of our results detected positive relationships between photoperiod and puncturing (mean numbers of oviposition and feeding punctures per day), and oviposition (oviposition punctures/oviposition feeding punctures) activities, and the proportion of squares attacked by boll weevil females. When boll weevil females developed in light:darkness cycles, they produced a significantly higher percentage of eggs developing to adulthood than those developed in 24-h light or dark conditions. In long photoperiod (24:0 and 14:10 h), the number of female progeny was significantly higher and their development time was significantly shorter than those developed in short photoperiod (0:24 and 10:14 h). Lifetime oviposition was significantly highest at 12- and 14-h photophase, lowest at 0- and 10-h photophase, and intermediate at 24 h of light. Life table calculations indicated that boll weevil populations developed in a photoperiod of 14:10 and 12:12 (L:D) h will increase an average of two-fold each generation (Ro) compared with boll weevils developed in 24:0- and 10:14-h photoperiods and 15-fold compared with those at 0:24 h. Knowledge of the photoperiod-dependent population growth potential is critical for understanding population dynamics to better develop sampling protocols and timing insecticide applications.", "label": "Yes"}
{"text": "To do: Speak with your child about hibernation then build a blanket fort to practice!\nTime: 30 minutes\nMaterials: Blankets, conversation\nWinter is coming, and some animals are preparing to hibernate the entire cold season! Does your child know what hibernation means, and would you like to practice? Let’s get started!\nOne definition of hibernation is “a state of inactivity and metabolic depression…that is characterized by low body temperature, slow breathing and heart rate, and low metabolic rate.”\nIn other words, hibernating animals don’t do much, or are inactive, and don’t have to eat as much because their metabolism slows down. Common animals that hibernate are bears, skunks, hedgehogs, squirrels, and bats.\nToday, practice hibernating in a cave of your own making, a.k.a a blanket fort! Set up a few chairs or a table, create a little den, and pretend you’re a bear in the wintertime.\nRecommended for you:", "label": "Yes"}
{"text": "In 2010 the University of Delaware’s apiary was rehabilitated and revitalized as a working, teaching apiary. The apiary consistently houses between 25-50 colonies during the peak season. A unique and special result of the increase in the number of colonies has been the production, harvest and marketing of Dare to Bee! Honey, featured in the UD creamery during the late summer and fall season. This honey is not only delicious but is produced by University bees and generates revenue that can be used to sustain the apiary.\nDare to Bee recent posts\n- We grafted queen cells from one of our best colonies last week, and I’ve got say they look great!Prep for this week‘s Apiculture lab at UD. We looked at a bunch of different methods to monitor for Varroa mites: sticky boards, powdered sugar rolls, alcohol washes, and even got to try my new CO2 device. Thankfully we had very low Varroa levels in all of the hives we tested.We had a beautiful Ag Day this year at University of Delaware. There was quite a crowd at the “bee cage” for live demos, and we got to educate hundreds of people about honey bees and other pollinators. Thanks to everyone who came! #udbeeteam #agday #honeybees #pollinators #springDespite some interruptions from the residents at our new location, we got our new research apiary set up this morning! #brewershideawayfarm #udbeeteam #galaxythecow #princessthehorseHanging some swarm trap boxes this year for the ones that get away. Wish us luck!The (last) big thaw", "label": "Yes"}
{"text": "Cardiovascular disease (CVD) is one of the leading causes of death worldwide and atherosclerosis is the primary underlying cause. Main risk factors for atherosclerosis are elevated plasma low-density lipoprotein-cholesterol (LDL-c) levels and inflammation. Leukocytosis, the expansion of white blood cells, positively associates with CVD in humans, independent of inflammation. Studies in animal models have demonstrated that high-density lipoprotein-cholesterol (HDL-c) suppresses leukocytosis. We found a negative association between HDL-c and blood leukocytes in the LifeLines DEEP cohort, as such providing translational evidence for the findings in animal models. Leukocytosis in humans with myeloproliferative diseases is accompanied by low plasma LDL-c levels. Regardless, these patients are at increased risk of CVD. We propose that this is due to leukocytosis, and that stem cells take up high amounts of LDL-c to induce their proliferation leading to leukocytosis, which decreases plasma LDL-c. We also focused on a specific leukocyte subset, T cells. During atherogenesis and aging, T cells accumulate cholesterol leading to differentiation into distinct subsets with either pro- or anti-inflammatory characteristics. To investigate the effect of T cell cholesterol accumulation on T cell aging and atherosclerosis, we generated a mouse model with combined deficiency of the cholesterol transporters ATP Binding Cassette A1 and G1 (ABCA1/ABCG1) specifically in T cells. T cell Abca1/Abcg1 deficiency increased T cell apoptosis and senescence, and decreased atherosclerosis in middle-aged mice. Our findings suggest that T cell cholesterol efflux pathways are crucial in maintaining peripheral T cell numbers and T cell tolerance, especially during aging.\n|Kwalificatie||Doctor of Philosophy|\n|Datum van toekenning||17-okt.-2022|\n|Plaats van publicatie||[Groningen]|\n|Status||Published - 2022|", "label": "Yes"}
{"text": "He has been so tired, so hurting, so wiped out. Sleeps all day. Cries when he wakes up. Photosensitive. Doesn't like to walk or move around.\nHe gets the spinal taps / intrathecal chemo twice per week. It was finally seeming to work (his CSF count went down to 1 this morning).\nHowever, they also did a head CT today, and compared it to several weeks ago.\nOn today's picture (the left one below) you can see the dark areas on the left edge of the picture.\nThose are pushing against his brain and compressing the middle part (the ventricles).\n|There should normally be a \"butterfly shaped dark area in the middle\nand it is compressed together because of the pressure from the left edge (dark areas).\n|Normal \"Butterfly\" shaped\nVentricular cavities (circled in red)\nThey do not think\nit looks like bleeding (not acute subdural hematoma) (new blood would be bright).\nSo it's either extra CSF fluid, infection, or pockets of leukemia.\nWe need to check that out - there is much discussion about how and how soon. We hate to poke into his head because of risks of bleeding (low platelets bad coagulation),\nand risk of infection (no white cells yet - marrow still empty five weeks out from 2-CDA chemo).\nThe neurospecialists think it is a Chronic Subdural Hygroma\n- possibly caused by either:\n#1) Negative CSF pressure\nfrom sequential traumatic spinal taps creating a separation space for the collection of CSF fluid - the pressure differences accumulating over time.\n#2) Small hematoma(s?)\nin the past, followed by water osmosis to the protein rich pocket of old blood. Osmotic pressure could have continued to grow the hygroma.\n#3) An infection\nwith the same osmotic water accumulation (not pus because he has no white cells yet)\n#4) Leukemia cells\n(but then why not 22 days ago when his CNS leukemia was worse?)\nSince that subdural area [a virtual area between the\ndura (brain cover)\nand the brain itself] does not communicate very well (isn't connected) with the ventricals of the brain\nconsequentially either of the last two options (infection/leukemia) may not have shown up in the bi-weekly spinal taps.\nAnother interesting question is whether the pressure sequestered (\"squeezed off\") an area with leukemia from the normal CSF fluid flow,\nand was both not getting treated with the bi-weekly chemo, and also giving us an unacurately lower CSF nucleated cell count.\nI think this is possible because for three taps (5th, 8th, 11th) the count hovered (4,5,4)\nand then started dropping.\nThat seemed to coincide with his clinical symptoms increasing.\nI was so busy focusing on the CNS counts, I hadn't been paying attention to some of the potential side-effects\nof the many lumbar punctures.\nThings like CSF-HypoVolemia\n, IntraCranial Hypotension\n, Tonsilliar Herniation\nEven the type of needle used makes a difference - either a cutting (Quincke) needle or a Atraumatic (Sprotte) needle\nIt seems research touts the benefits (less headaches\n, and leakage\n) of using the latter.\nWill have to check on that a bit more.\nTomorrow morning he is going in for surgery (drilling a hole into his head)\n. That will give them time to prepare - give him blood and platelets first.\nAlso then there will be a full team at hand because of his delicate condition.\nIf they observe pressure that will help them understand more about these fluid pockets.\nThen they can also send it in for cytometry\nto find out if there is cancer present.\nThey will leave a drain in his head for at least 24 hours, that way the brain can re-expand without pushing against positive fluid pressure.\nHe will be in intensive care afterwards.\nThat brings back memories", "label": "Yes"}
{"text": "The silly feline duo of Cole & Marmalade graciously allowed themselves to be studied by their beleaguered human Chris and personally demonstrated the incredible range of emotions that felines have and how they go about expressing those emotions.\nThe science of cats, do cats show emotions? … Of course they do! I’ve been owned by cats all my life and for the past few years I’ve been conducting an highly scientific research project on cat emotions, here are the results I managed to document.I’m sure there are many more cat emotions left to be discovered…. But I’m still not sure that cats feel guilt, what about you?", "label": "Yes"}
{"text": "Ferroptosis, a type of iron-dependent programmed cell death distinct from apoptosis, necroptosis, and other types of cell death, is characterized by lipid peroxidation, reactive oxygen species production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury. Therefore, ferroptosis has become a major focus for translational research. However, despite its involvement in pathological conditions, there are no pharmacologic inhibitors of ferroptosis in clinical use. In the context of drug repurposing, a strategy for identifying new uses for approved drugs outside the original medical application, we discovered that vitamin K1 is an efficient inhibitor of ferroptosis. Our findings are strengthened by the fact that the vitamin K antagonist phenprocoumon significantly exacerbated ferroptotic cell death in vitro and also massively worsened the course of acute kidney injury in vivo, which is of utmost clinical importance. We therefore assign vitamin K1 a novel role in preventing ferroptotic cell death in acute tubular necrosis during acute kidney injury. Since the safety, tolerability, pharmacokinetics, and pharmacodynamics of vitamin K1 formulations are well documented, this drug is primed for clinical application, and provides a new strategy for pharmacological control of ferroptosis and diseases associated with this mode of cell death.\nKeywords: Acute kidney injury; Ferroptosis; Ischemia–reperfusion injury; Vitamin K.\n© 2022. The Author(s).", "label": "Yes"}
{"text": "Best Probiotic Supplements\nHow Long Does It Take For Probiotics To Start Working …\nWhat can help, she noted, is eating a more plant-based diet. “These healthy animals that live in our guts have to eat what we consume, and they like fiber from plant foods – Probiotic Supplements.\nProbiotics are made of both germs and yeast. Common probiotic germs can consist of lactobacillus and bifidobacterium. The most typical yeast discovered in probiotics is saccharomyces boulardii.\nProbiotics are comprised of excellent bacteria that assists keep your body healthy and working well. This great germs assists you in numerous ways, consisting of combating off bad bacteria when you have too much of it, assisting you feel much better. Probiotics belong to a larger picture concerning bacteria and your body your microbiome.\nDo Probiotic Supplements Actually Work? – Andy The Rd\nThis community is made up of things called microorganisms. You have trillions of microbes on and in your body. These microorganisms are a combination of: Bacteria. Fungi (consisting of yeasts). Infections. Protozoa. Everybody’s microbiome is distinct. No 2 people have the exact same microbial cells even twins are various. For a microorganism to be called a probiotic, it should have a number of attributes.\nWhere do beneficial probiotics (microorganisms) live in my body? The most typical place linked to advantageous microorganisms is your gut (primarily big intestines), you have several places in and on your body that host excellent microorganisms.\nHow do probiotics work? The primary job of probiotics, or excellent bacteria, is to maintain a healthy balance in your body. When you are sick, bad bacteria enters your body and increases in number.\nShould You Take A Daily Probiotic Supplement? – Md Anderson …\nGood bacteria keeps you healthy by supporting your immune function and controlling swelling. Certain types of great germs can also: Help your body digest food. Keep bad germs from leaving control and making you sick. Develop vitamins. Assist assistance the cells that line your gut to avoid bad germs that you might have consumed (through food or drinks) from entering your blood.\nThis balancing act is naturally occurring in your body all of the time. You don’t actually require to take probiotic supplements to make it take place. Great bacteria is just a natural part of your body. Consuming a healthy diet rich in fiber every day helps to keep the number of good germs at appropriate levels.\nThese include: Lactobacillus. Bifidobacterium. Probiotics are also made up of good yeast. The most typical kind of yeast discovered in probiotics is: Can I utilize probiotics to help with medical conditions? There is presently a large amount of research study happening around the idea of what probiotics can do for your body.\nDo Probiotics Help Arthritis Symptoms? – Arthritis Foundation\nHowever, there are some medical conditions where probiotics may assist. This can differ between people indicating that what works for someone may not work for another. These can likewise differ based upon the certain probiotic that is taken. Some of the conditions that might be assisted by increasing the quantity of probiotics in your body (through food or supplements) include: Can I take or consume something to increase the good probiotics (microbes) in my body? You can increase the amount of good microorganisms in your body through foods, drinks and supplements.\nFermented foods in particular (yogurt and pickles, for example) are home to a host of good bacteria that benefit your body. There are likewise fermented drinks like kombucha (fermented tea) or kefir (fermented dairy beverage) that present additional probiotics into your diet. Probiotic Supplements. Apart from food, you can include probiotics to your diet plan through dietary supplements.\nCan I get probiotics from food? Certain foods have probiotics (great bacteria) in them and can benefit the health of your microbiome.\nHow Do Probiotics Work? – Kerry Health And Nutrition Institute\nYou may even be regularly consuming them now and not realize that they include probiotics. You will wish to examine the food label for “live and active cultures.” A few tips for just some of the probiotic-rich foods you can add to your diet plan and long times to attempt them consist of: For breakfast, try: Yogurt – Probiotic Supplements.\nSourdough bread. For lunch, shot: Cottage cheese. Kombucha. Tempeh. For a treat, try: For dinner, try: Fermented sauerkraut. Kimchi. Miso soup. Make sure you are still developing a balanced and healthier meal each time you sit down to consume. Though including probiotic-rich foods into your diet plan won’t hurt you, balance is still key.\nHow do I take a probiotic supplement? There are a number of methods you can take a probiotic supplement. They are available in a range of types, consisting of in: Foods. Drinks. Capsules or tablets. Powders. Liquids. Probiotic supplements might be integrated with a prebiotic. Prebiotics are complicated carbohydrates that feed the microbes in your gut.\nPre And Probiotics: What Are They And How Do They Work …\nThey help feed the excellent bacteria and keep it healthy. Prebiotics consist of inulin, pectin and resistant starches. When you have a supplement that integrates a probiotic and prebiotic, it’s called a synbiotic. How effective are probiotics? Researchers are presently uncertain how reliable probiotic supplements are for treating conditions. There’s constant research on the topic.\nIt’s also crucial to bear in mind that unlike medications, dietary supplements do not need to be authorized by the FDA. This means that makers can offer supplements merely with “claims” of safety and effectiveness. Always talk with your doctor (or pediatrician) before taking a supplement or offering one to your kid (Probiotic Supplements).\nIf you are pregnant or breast feeding, check with your provider before taking any supplement. Exist any storage instructions for probiotics? Several probiotic pressures are extremely delicate and require to be secured from heat, oxygen, light and humidity. The probiotics might begin to break down or die if they are exposed to these aspects.\nHow Do Probiotics Work? – Kerry Health And Nutrition Institute\nCooling particular probiotic pressures guarantees that they’re still feasible when you go to use them and will still offer the full advantage of the probiotic. Since microorganisms utilized as probiotics already exist naturally in your body, probiotic foods and supplements are usually considered safe.\nThere are specific individuals who need to use care when utilizing probiotic supplements. These people include those who have: A weakened immune system (those going through chemotherapy for example). Care should also be utilized when offering probiotics to really sick infants.\nCan probiotics hurt me? For the majority of healthy people, probiotics do not cause any harm. They are normally considered safe and are typically “offered a shot” to see if they could aid with numerous medical conditions. There’s a lot of research study around the subject of probiotics. Researchers are trying to identify when and how they need to be utilized, as well as how effective they are.\nThe Risks And Benefits Of Probiotics – Consumer Reports\nIt’s constantly best to have the conversation first prior to beginning a new supplement. Probiotics are generally considered safe.\nDeveloping damaging by-products from the probiotic supplement. Should I offer probiotics to my kids? If your kid has an illness that requires an antibiotic medication for treatment, taking a probiotic can help reduce signs.\nFoods like yogurt and cottage cheese are often part of a balanced diet and can include good germs without much threat – Probiotic Supplements. There are commercially available probiotic supplements specifically designed for babies and children. Nevertheless, it is very important to talk with your child’s pediatrician prior to offering them any probiotic supplement or changing the kid’s diet plan to include probiotic-rich foods.\nThe Absolute Best Time To Take Your Probiotic – Parsley Health\nNevertheless, while antibiotics are eliminating the bad bacteria, they are likewise knocking out the excellent bacteria in your body. Some individuals establish conditions like diarrhea after taking an antibiotic. In other individuals, this might enable truly bad germs to take control of and occupy the gut, such as with C.\nSome research has shown a positive connection in between taking probiotics after an antibiotic and remedy for diarrhea. This hasn’t been shown yet and does not work for everyone – Probiotic Supplements. The thought behind including probiotics back into your body after taking an antibiotic is that it can repopulate the good germs that was destroyed by the antibiotics and re-boot your system.\n9 million Americans use such items – Probiotic Supplements. Some research studies suggest that probiotics may assist with diarrhea or symptoms of irritable bowel syndrome (IBS), however strong proof to support their use for many health conditions is lacking, according to the National Center for Complementary and Integrative Health. In addition, a lot of studies that have looked at the effects of probiotics have used participants’ stool samples as a proxy for what’s going on in their guts.\nThe Benefits Of Probiotics – Improving Our Immune & Digestive …\nIn the brand-new research study, the scientists analyzed info from 15 healthy volunteers who took either a probiotic product containing 11 strains of bacteria, or a placebo, for 4 weeks. The individuals likewise went through colonoscopies and upper endoscopies prior to they took the probiotics or the placebo, and once again after the four-week treatment duration.\nThe scientists found that the probiotic bacteria had the ability to colonize the gut in 6 individuals. The rest, nevertheless, were “resisters,” meaning the germs did not colonize their guts, despite the fact that the probiotic germs were shed in their stool.”Although all of our probiotic-consuming volunteers revealed probiotics in their stool, only a few of them showed them in their gut, which is where they need to be,” co-senior author Eran Segal, a computational biologist at the Weizmann Institute, said in the statement.\nThis forecast method requires to be verified in future studies. The researchers called for more research to better understand why some people resist colonization by probiotics, as that future research study might allow researchers to combat the resistance. Harmful effects?\nPrebiotics & Probiotics – Gastrointestinal Society\nThe finding also highlighted the requirement for personalized probiotic treatments to safeguard individuals’s gut health “without jeopardizing microbiome recolonization” after prescription antibiotics, the scientists stated. Dr. Arun Swaminath, director of Inflammatory Bowel Illness Program at Lenox Hill Medical Facility, who was not associated with the research study, stated these findings “raise concerns about whether probiotics really delaythe return of [a] healthy bacteria community after” an individual takes certain prescription antibiotics.\n“But it plainly shows that probiotics might have an unjust status, in the method they are presently believed of in popular culture as natural and unarguably healthy.”The researchers likewise noted that they did not take a look at scientific results, such as whether probiotics helped to reduce individuals’s gastrointestinal symptoms. Original post on. Probiotic Supplements.\nProbiotics may have been gaining popularity in recent yearsbut think it or not, probiotics have actually been around because the early 19th and 20th centuries in some fashion or another. In those times, biologists discovered germs and yeast were used in the fermentation process and connected them to favorable health results.\nHow Do Probiotics Work? – Probiotics Learning Lab\nThis implied less strenuous standards for supplementsincluding probiotics. As an outcome, probiotics might be offered over the counter, which enabled consumers to acquire them more easily (Probiotic Supplements). What are probiotics?\nYou have a considerable quantity of great bacteria in your gut (more particularly in the intestinal tracts and digestive tract) that is essential for keeping you healthy and processing the food you consume. In reality, microbes like germs surpass human cells in your body 10 to one. “Probiotics, in essence, are the good germs in our gut microbiota,” says Jenna-Ann Del Borrello, a registered dietitian in New york city City.\nWhile probiotics have various germs species or pressures, the 2 most common germs pressures discovered in probiotics include: Lactobacillus and Bifidobacterium (Probiotic Supplements). Probiotic products include dietary supplements or foods with natural probiotics (like fermented foods such as kimchi and sauerkraut) or included probiotics such as Activia yogurt. As tablets or pills, probiotics can be bought over-the-counter or with a prescription.\nProbiotic Supplements Review (Including Pet Probiotics …\nWhat do probiotics do? There are numerous advantages of probiotics, but most notably, they are used to treat GI health conditions as they help stabilize out the excellent and bad germs in the gut. Probiotics can: There is a great deal of speculation over the effectiveness of probiotics because there is restricted research (Probiotic Supplements).\nThis is because probiotics can be found in numerous ranges with many different pressures, and it’s yet to be seen if all variations of a particular strand would produce the very same benefits. For instance, if a specific type of Lactobacillus assists avoid an illness, that doesn’t always indicate that another type of Lactobacillus would have the same result – Probiotic Supplements.\nWhat is the best probiotic? It is tough to state what the best probiotic is due to the fact that the effects of probiotics are different for each individual.", "label": "Yes"}
{"text": "buy Lyrica from canada ratingTechnology broughthygiene to the next level with the introduction of dental endoscopy over a decadeago. Thesympatheticcomponent causes the rate of contraction to increase (an ef-fect known astachycardia) and increases the force ofmusclecontraction Thesympatheticcomponent causes the rate of contraction to increase (an ef-fect known astachycardia) and increases the force ofmusclecontraction. If ingested byrequirement buy Lyrica from canada a large proportion of available Cys is used for protein synthesis and GSH.Protein turnover and hydrolysis of GSH by the ?-glutamyl transpeptidase and dipeptidaseenzyme will result in the release of new Cys at amino acid pool. selective surfactant and continued mechanical ven-tilation for preterm infants with or at risk for respira-tory distress syndrome. For ‘physical’, the effectsizes are 9.86, 15.46, and 3.93 as age increases, which shows no obviousmonotonic increase or decrease. The last of these is also preferred sometimes inthe UK buy Lyrica from canada when some service recipients object to the term ‘user’.\n5-5 stars based on 159 reviews\nLiver is the primary site (also salivaryglands and kidneys). J Pediatr Surg 38:283–289; discussion 283–289Hoskote A et al (2004) Oxygenation and systemic, cere-bral and pulmonary vascular haemodynamics after thebidirectional superior cavopulmonary shunt.\nInsome studies, selected controls may be found subsequently to have missingkey information, and so may be excluded from the statistical analysis.Therefore, although researchers specify the target number of controls per case,the number actually recruited and analysed may be less. Divergenteffects of ephedrine and phenylephrine on cardiovascular hemodynamics of near-term fetalsheep exposed to hypoxemia and maternal hypotension. Correlation with beta-adrenergic receptordownregulation. Withincreasing anesthetic depth, there is a progres-sive decrease in alveolar ventilation with a reduc-tion in tidal volume and an increase in PaCO 2 inspontaneously breathing patients. (2004) Paroxetine doesnot improve symptoms and impairs cognition in frontotemporaldementia: a double-blind randomized controlled trial (2004) Paroxetine doesnot improve symptoms and impairs cognition in frontotemporaldementia: a double-blind randomized controlled trial. As a result, decision-makers are increasingly scrutinized for the reason-ableness of their decisions. In particular cell types,such as developing rat retina and retinal ganglion cells buy Lyrica from canada p53 can stimulate expres-sion of catalase, another enzyme involved in H2O2 decomposition . ( b) On 2Dimage buy Lyrica from canada it is seen as a nodular lesion ( arrow) containing air density. Computerized monitoring system in neurosurgical intensivecare. Nosocomial ventriculitis and meningitis in neurocritical carepatients. At one site, three distinct granules (arrows) are evident. 8.32 Airway pressurerelease ventilation differsfrom conventional modesbecause trigger initiates adrop in airway pressure ratherthan a rise 8.32 Airway pressurerelease ventilation differsfrom conventional modesbecause trigger initiates adrop in airway pressure ratherthan a rise. Their framework isoriented as a matrix that shows the linkage between principles to guide behavior,structures within organization that facilitate or impair teamwork and collaboration,and processes that enable professional activity.\nShadowing artifactappears as a hypoechoic or anechoic region extending downward from a very strongattenuating medium. Theprostate gland consists of two lobes separated by a shallowgroove called the median sulcus (Fig. 11.3 A pneumotachograph, consisting of a differen-tial pressure transducer to measure the drop across aknown resistance. This is regardless of the onset of sexual activity, which-ever comes first. The LES is a 4-cm segment of circular muscle in thedistal esophagus that is tonically closed because of the intrinsic myogenic properties of thisspecialized segment The LES is a 4-cm segment of circular muscle in thedistal esophagus that is tonically closed because of the intrinsic myogenic properties of thisspecialized segment. The second phase is characterizedby an increase in renal release of vasodilating prostaglandins,leading to venodilation, and decreased preload and ventricularfilling pressures.10 The latter effects may explain the nearlyimmediate symptomatic improvement often noted in patientswith acute pulmonary edema, which may precede the onset ofactual diuresis.2 With prolonged use, a compensatory activationof the sympathetic nervous system occurs and can lead to chronicadaptations known as the “braking” effect. kingae may be found in the oro-pharynx of infected children.", "label": "Yes"}
{"text": "Roles for the endocannabinoid system in ethanol-motivated behavior.\nRecent studies have indicated a role for the endocannabinoid system in ethanol-related behaviors. This study examined the effect of pharmacological activation, blockade, and genetic deletion of the CB(1) receptors on ethanol-drinking behavior in ethanol preferring C57BL/6J (B6) and ethanol nonpreferring DBA/2J (D2) mice. The deletion of CB(1) receptor significantly reduced the ethanol preference. Although the stimulation of the CB(1) receptor by CP-55,940 markedly increased the ethanol preference, this effect was found to be greater in B6 than in D2 mice. The antagonism of CB(1) receptor function by SR141716A led to a significant reduction in voluntary ethanol preference in B6 than D2 mice. A significant lower hypothermic and greater sedative response to acute ethanol administration was observed in both the strains of CB(1) -/- mice than wild-type mice. Interestingly, genetic deletion and pharmacological blockade of the CB(1) receptor produced a marked reduction in severity of handling-induced convulsion in both the strains. The radioligand binding studies revealed significantly higher levels of CB(1) receptor-stimulated G-protein activation in the striatum of B6 compared to D2 mice. Innate differences in the CB(1) receptor function might be one of the contributing factors for higher ethanol drinking behavior. The antagonists of the CB(1) receptor may have therapeutic potential in the treatment of ethanol dependence.", "label": "Yes"}
{"text": "Shivering is a reflexive response of the body to cold temperatures or as a response to fever, infection, or other medical conditions. It is a mechanism by which the body generates heat to maintain its temperature. Shivering involves rapid and involuntary contractions of the muscles, which generate heat through increased metabolic activity.\nShivering can be a normal and healthy response to cold temperatures, but it can also be a sign of an underlying medical condition. In addition to cold exposure and fever, other possible causes of shivering include hypoglycemia (low blood sugar), hypothyroidism (an underactive thyroid gland), anxiety, and side effects of certain medications.\nTreatment of shivering depends on the underlying cause. If shivering is due to cold exposure, it can be treated by warming the body with warm clothing, blankets, or a heating pad. In cases of fever, treating the underlying infection or illness can help to reduce shivering. If shivering is due to an underlying medical condition, treatment of that condition can help to alleviate symptoms.\nIn some cases, medications such as acetaminophen or ibuprofen may be used to reduce fever and relieve discomfort associated with shivering. If shivering is severe or persistent, or if it is accompanied by other concerning symptoms, it is important to seek medical attention.", "label": "Yes"}
{"text": "|Posted on February 15, 2015 at 9:00 AM|\nAccording to a Cochrane Database abstract \"The World Health Organization (WHO) recommends administration of an oral dose of 200,000 IU (or 100,000 IU in infants) of vitamin A per day for two days to children with measles in areas where vitamin A deficiency may be present.\" (Cochrane Database Syst Rev. 2002;(1):CD001479).\nIf the World Health Organization recommends this why aren't we hearing about this in America? Vaccinations are not providing complete protection against the measles virus. Four out of the ten measles cases at Disney World were previously vaccinated. The U.S. vaccination governing body is now stating that not only is one MMR vaccination insufficient, two vaccinations may not be sufficient, and now they are recommending that we receive three vaccinations. How many will we have to get before they become effective?\nThe human body has been designed to adequately handle many health conditions when properly supplied with balanced nutrition. Americans are famously overfed and starving for real nutrition. There are some very hopeful possibilities that will likely sooner or later get the media attention they deserve.\nFind out more about our Designed Clinical Nutrition at http://www.fallchiropractic.com/nutritional-assessments.", "label": "Yes"}
{"text": "Over the course of the last 20 years, we have established a comprehensive portfolio of models for the large number of species that we supply feeds for. The purpose of these models is to forecast how fish and shrimp will perform in their surrounding conditionsand to give cost-benefit evaluations for different farming situations\nResearch & development\nThe development process for AquaSim began 20 years ago, when Skretting generated growth models for salmon and other fish species. In the last 5 years, we have been developing the concept further for shrimp based on research, experimentation and validation.\nOur AquaSim tools are well established for many species of fish and shrimp, and provides tools based on three criteria: biology, quality and economics. The models are easy to use and require custom inputs from the farmer, including farm dimensions, stocking plan, feed and feeding regime as well as water quality parameters.\nFrom these inputs, a range of data can be obtained, from harvest dates to feed selection, making AquaSim an essential tool for efficient planning, forecasting and benchmarking.\nOptimising farm performance\nOver the years, we have developed numerous models to help optimise farm performance. The growth model for instance, is based on body weight, and calibrated using commercial farming data. The FCR model provides a biological FCR based on body weight. Each Skretting diet has a unique FCR model, based on research done by Skretting Acuaculture Research Centre (ARC), which tests all raw materials and diets both in the lab and under field conditions.\nFarm management in your hands\nAquaSim can be accessed via our online portal and can be used on PC, tablets or smartphones.", "label": "Yes"}
{"text": "A group of researchers and scientists revealed reasons for understanding why Corona virus vaccines from AstraZenka and Johnson & Johnson cause rare but fatal blood clots, after recording a number of cases, which angered some and made them feel so reluctant to take vaccines.\nAl-Arabiya Net quoted the German researcher, Dr. Andreas Grencher, that he found the chemical in the “AstraZenka” vaccine that leads to an immune reaction that produces those rare side effects that were recorded in a few people who received the vaccine, explaining that a preservative in the Covid-19 vaccine A subsidiary of “AstraZeneca” may lead to a rare over-reaction of the immune system that causes blood clots, according to the newspaper “The Wall Street Journal”.\nThe German professor and his team identified more than 1,000 proteins in the AstraZeneca vaccine derived from human cells, as well as a preservative known as ethylene diaminetracitic acid, or EDTA, that may trigger an overactive immune reaction by forming clumps using platelets in the bloodstream.\nHe also explained that inflammation caused by vaccines, in addition to PF4 compounds, can trick the immune system into thinking that the body has been infected with the bacteria, leading to an old defense mechanism that gets out of control and causes clotting and bleeding.\nProfessor John Kelton of McMaster University in Canada, whose group runs a reference laboratory to examine patients with symptoms of blood clotting after vaccination, said that the laboratory had repeated some of Greensher’s research and confirmed his findings.\nHowever, Kelton explained that the reasons are not yet clear “enough”, indicating that Greensher’s hypothesis may be correct, but it may also be false.\nSome scientists believe that the viruses themselves could play a role in triggering the condition because they are linked to blood clotting. Others speculate that infected people may have a genetic predisposition, or that their immune systems have previously developed the problematic antibody.\nThe World Health Organization announced last April that the link between the AstraZeneca vaccine against the Coronavirus and the emergence of a rare form of blood clots is “possible but not certain.”\nThe organization’s experts in the field of vaccines said earlier that specialized studies must be conducted in order to fully understand the possible link between vaccination and possible risk factors, noting that these phenomena are very rare despite being worrisome, noting that more than 200 million people have received the AstraZeneca vaccine – Oxford.\nLoma News is a news search engine, and Loma News disclaims all responsibility for the content of the news Yemen News Finally … Scientists reveal the secret behind the occurrence of deadly strokes from some Corona vaccines Or the pictures, but the responsibility rests on the original publisher of the news and the source hayrout.com, as the original publisher bears the copyright and intellectual property rights of the news. This news has been automatically transmitted.", "label": "Yes"}
{"text": "Human γ-Aminobutyric acid transporter 1 (hGAT1) is a Na + /Cl − dependent co-transporter that plays a key role in the inhibitory neurotransmission of GABA in the brain. Due to the lack of structural data, the exact co-transport mechanism of GABA reuptake by hGAT1 remains unclear. To examine the roles of the co-transport ions and the nature of their interactions with GABA, homology modeling and molecular dynamics simulations of the hGAT1 in the open-to-out conformation were carried out. Our study focused on the sequential preloading of Na + and Cl − ions, followed by GABA binding. Our simulations showed pre-loading of ions maintains the transport ready state of hGAT1 in the open-to-out conformation essential for GABA binding. Of the four putative preloaded states, GABA binding to the fully loaded state is most favored. Binding of Na + ion to the Na1 site helps to maintain the open-to-out conformation for GABA binding as compared to the Na2 site. GABA binding to the mono-sodium or the di-sodium loaded states leads to destabilization of Na + ions within their binding sites. The two most prominent interactions required for GABA binding include interaction between carboxylate group of GABA with the bound Na + ion in Na1 binding site and the hydroxyl group of Y140. Overall our results support the fully loaded state as the predominate state for GABA binding. Our study further illustrates that Na + ion within the Na1 site is crucial for GABA recognition. Therefore, a revised mechanism is proposed for the initial step of hGAT1 translocation cycle.\n|Original language||English (US)|\n|Number of pages||9|\n|Journal||Computational and Structural Biotechnology Journal|\n|State||Published - 2019|\nBibliographical noteFunding Information:\nSupport was provided by HEC ‘Indigenous Ph.D. Fellowship for 5,000 scholars’ Phase-II, Batch-I, 2012. University of Minnesota Supercomputing Institute provided all the necessary computational resources.\n- Conformational analysis\n- GABA transporter 1\n- Molecular dynamics simulations\n- hGAT1 translocation cycle", "label": "Yes"}
{"text": "2.2- Second Professional B.D.S:\nAt the end of the course the student should be competent to apply the scientific study of diseaseprocesses, which result in morphological and functional alterations in cells, tissues andorgans to the study of pathology and the practice of dentistry.\nEnabling the student\n1. To demonstrate and apply basic facts, concepts and theories in the field of Pathology.\n2. To recognize and analyze pathological changes at macroscopically and microscopical levels and explain their observations in terms of disease processes.\n3. To Integrate knowledge from the basic sciences, clinical medicine and dentistry in the study of Pathology.\n4. To demonstrate understanding of the capabilities and limitations of morphological Pathology in its contribution to medicine, dentistry and biological research.\n5. To demonstrate ability to consult resource materials outside lectures, laboratory and tutorial classes.\n126.96.36.199- SEMESTER I:\n1. CELL INJURY:\na. Terms necrosis, ischemia, hypoxia, infarction and gangrene.\nb. Sequence of the ultrastructural and biochemical changes which occur in the cell in response to the following:\nImmunological injury-eg. Asthma / SLE /Anaphylactic reaction\nPhysical agents: eg. Radiation\nGenetic defects- eg. Thalassemia / haemophilia\nViruses: eg. Hepatitis / Aids / HIV infections\nFungi: eg. Staphylococcus\nParasites: eg. Malaria\nc. Irreversible and reversible injury.\nd. Apoptosis and its significance.\ne. Necrosis and its types.\nf. Exogenous and endogenous pigment deposition\ng. Dystrophic and metastatic calcification along with clinical significance.\nh. Metabolic disorders\n2. INFLAMMATION AND MEDIATORS OF INFLAMMATION\na) Describe the role of inflammation in the defense mechanisms of the body.\nb) Describe the vascular changes of acute inflammation and relate these to the morphological and tissue effects.\nc) Describe the process of chemotaxis, opsonization and phagocytosis.\nd) Describe the role of cellular components in inflammatory exudate.\ne) Differentiate between exudate and transudate.\nf) List the important chemical mediators of inflammation\ng) Describe the pathway of Archidonic Acid metabolism.\nh) Discuss the role of products of Archidonic acid metabolism in inflammation.\ni) Describe the mechanism for development of fever, with reference to exogenous and endogenous pyrogens.\nj) Describe chronic inflammation including granulomas.\nk) Describe granuloma , its type and causes.\nl) Describe the systemic effects of acute and chronic inflammation and their possible outcomes.\nm) Describe the signification of ESR.\n3. WOUND HEALING\na) Describe the differences between repair and regeneration.\nb) Describe wound healing by first and second intention.\nc) Discuss the factors that influence the inflammatory reparative response.\nd) Compare wound contraction with cicatrization.\ne) Describe the formation of granulation tissue.\nf) Describe the complications of wound healing.\n4. DISORDERS OF CIRCULATION\na) THROMBO-EMBOLIC DISORDERS AND THEIR MODALITIES:\n1. Explain the pathogenesis of thrombosis.\n2. Describe the possible consequences of thrombosis.\nb) DISORDERS OF THE CIRCULATION AND SHOCK\n1. Define edema, ascites, hydrothorax and anasarca.\n2. Describe the pathophysiology of edema with special emphasis on CHF.\n3. Describe the pathogenesis of four major types of shock (Hypovolemic, cardiogenic, vasovagal and septic) and list their causes.\n4. Describe the compensatory mechanisms involved in shock.\nDescription of Neoplasia Characteristics of bengin and malignant tumors, Spread of tumours, Pre-disposing factors, etiology carcingenesis, classification, Skin tumours Bengin Malignant.\nDescription of hereditary and related disorders\n1. Histopathological presentations: Necorsis, Acute Inflammation, Chronic Inclammation, Granulation tissue, Granulomatous inflammation, Fatty Change.\n2. Study of Microscope\n3. Sterlization methods\n4. Simple Staining methods\n5. Culture Medias\n6. Gram staining\n7. Zeihl Nelson staining\n8. Histopathological presentations: Beningn Tumour (leiomyoma ), Malignant Tumour (leiomyosaecema), Sq. cell Ca, Papillioma, Basal Cell Ca,\n9. Serology (widal test)\n188.8.131.52- SEMESTER II:\nIntroduction to Hematopoietic System Red cell disorder Anemia’s , White cell disorder, Leukemia’s, Platel disorders, Bleeding disorders, Blood transfusion Blood groups, Blood Chemistry\nDescription of Antigen, Antibody, Complement, Immune responses, Adverse immune reaction, HLA Tissue transplantation.\nDescription of G.I.T. Disorders (Oral lesions, Infections, Ulcerations, tumours, Congenital defects), Liver Disorders (Jaundice, Hepatitis Lab, Investigation), Bones & JointsDisorders (Osteomyelitis, Paget’s disease, Bone tumours), Circulatory System Disorders (Arterioscleroses, Hypertension, IHD, Rheumatic fever), Nervous System Disorders (Meningitis, Facial nerve palsy), Respiratory System Disorders (Pneumonia, tuberculosis, Tumours), Hormonal disease (Diabetes Mellitus, Thyroid, Pituitary).\nTHE ORAL CAVITY:\na. Predisposing factors (pipe smoking, ill fitting denture, alcohol abuse, irritant foods) of leukoplakia.\nb. Clinical and morphological features of oral cancer.\nc. Benign and malignant tumours of salivary glands.\nd. Clinical and morphological features of plemorphic adenoma.\na. Study of Blood Culture & Sensitivity\nb. Study of Anaerobic bacterial culture\nc. Study of Total Leukocyte Count & Differential Leukocyte Count\nd. Study of Blood Grouping methods\ne. Study of Bleeding Time & Clotting Time\nf. Study of Blood transfusion, Blood groups\ng. Study of micro-organisms: Staphylococci, Streptococci, Corynebacterium diphtheria, M. Tuberculosis, Clostridium, Plasmodium.\nh. Urine examination\ni. Stool examination\nj. Study of Blood Chemistry\n184.108.40.206- RECOMMENDED BOOKS\nBasic Pathology BY Robbin & Kumar\nTo introduce the students to the exciting world of microbes. To make the students aware of various branches of microbiology, importance, significance and contribution of each branch to mankind and other fields of medicine. The objectives of teaching microbiology can be achieved by various teaching techniques such as :\nb) Lecture Demonstrations\nc) Practical exercises\nd) Audio visual aids\ne) Small group discussions with regular feed back from the students.\nA. Knowledge and Understanding\nAt the end of the Microbiology course the student is expected to :\n1. Understand the basics of various branches of microbiology and able to apply theknowledge relevantly.\n2. Apply the knowledge gained in related medical subjects like General Medicine and General Surgery and Dental subjects like Oral Pathology, Community Dentistry,\nPeriodontics, Oral Surgery, Pedodontics, Conservative Dentistry and Oral medicine in higher classes.\n3. Understand and practice various methods of Sterilisation and disinfection in dental clinics.\n4. Have a sound understanding of various infectious diseases and lesions in the oral cavity.\n1. Student should have acquired the skill to diagnose, differentiate various oral lesions.\n2. Should be able to select, collect and transport clinical specimens to the laboratory.\n3. Should be able to carry out proper aseptic procedures in the dental clinic.\n220.127.116.11- SEMESTER I:\n1. GENERAL MICROBIOLOGY:\na. History, Introduction, Scope, Aims and Objectives.\nb. Morphology and Physiology of bacteria.\nc. Detail account of Sterlisation and Disinfection.\nd. Brief account of Culture media and Culture techniques.\ne. Basic knowledge of selection, collection, transport, processing of clinical Specimens and identification of bacteria.\nf. Bacterial Genetics and Drug Resistance in bacteria.\na. Infection – Definition, Classification, Source, Mode of transmission and types of Infectious disease.\nc. Structure and functions of Immune system\nd. The Complement System\nf. Immunoglobulins – Antibodies – General structure and the role played in defense mechanism of the body.\ng. Immune response\nh. Antigen – Antibody reactions – with reference to clinical utility.\ni. Immuno deficiency disorders – a brief knowledge of various types of immunodeficiency disorders – A sound knowledge of immuno deficiency disorders relevant to dentistry.\nj. Hypersensitivity reactions\nk. Autoimmune disorders – Basic knowledge of various types – sound knowledge of autoimmune disorders of oral cavity and related structures.\nl. Immunology of Transplantation and Malignancy\n18.104.22.168- SEMESTER II:\n1. SYSTEMATIC BACTERIOLOGY:\nI. Pyogenic cocci – Staphylococcus, Streptococcus, Pneumococcus, Gonococcus, Meningococcus – brief account of each coccus – detailed account of mode of spread, laboratory diagnosis, Chemo therapy and prevention – Detailed account of Cariogenic Streptococci.\nII. Corynebacterium diphtheriae – mode of spread, important clinical feature, Laboratory diagnosis, Chemotherapy and Active immunisation.\nIII. Mycobacteria – Tuberculosis and Leprosy\nIV. Clostridium – Gas gangrene, food poisoning and tetanus.\nV. Non-sporing Anaerobes – in brief about classification and morphology, in detail about dental pathogens – mechanism of disease production and prevention.\nVI. Spirochaetes – Treponema pallidum – detailed account of Oral Lesions of syphilis, Borrelia vincentii.\nb. General properties, cultivation, host – virus interaction with special reference to Interferon.\nc. Brief account of Laboratory diagnosis, Chemotherapy and immuno prophylaxis in general.\nd. A few viruses of relevance to dentistry.\ni. Herpes Virus\nii. Hepatitis B Virus – brief about other types\niii. Human Immunodeficiency Virus (HIV)\niv. Mumps Virus\nv. Brief – Measles and Rubella Virus\ne. Bacteriophage – structure and Significance\na. Brief Introduction\nb. Candidosis – in detail\nc. Briefly on oral lesions of systemic mycoses.\na. Brief introduction – protozoans and helminths\nb. Brief knowledge about the mode of transmission and prevention of commonly seen parasitic infection in the region.\n22.214.171.124- RECOMMENDED BOOKS\nMicrobiology Lipincott’s Illustrated Reviews\nMedical Microbiology (Jawetz, Melnick & Adelberg)\nThe broad goal of teaching under graduate students in pharmacology is to inculcate rational and scientific basis of therapeutics keeping in view of dental curriculum and Profession.\nAt the end of the course the student shall be able to:\ni) Describe the pharmacokinetics and pharmacodynamics of essential and commonly used drugs in general and in dentistry in particular.\nii) List the indications, contraindications; interactions, and adverse reactions of commonly used drugs with reason.\niii) Tailor the use of appropriate drugs in disease with consideration to its cost, efficacy, safety for individual and mass therapy needs.\niv) Indicate special care in prescribing common and essential drugs in special medical situations such as pregnancy, lactation, old age, renal, hepatic damage and immuno compromised patients.\nv) Integrate the rational drug therapy in clinical pharmacology.\nvi) Indicate the principles underlying the concepts of “Essential drugs”.\nAt the end of the course the student shall be able to:\n1) Prescribe drugs for common dental and medical ailments.\n2) To appreciate adverse reactions and drug interactions of commonly used drugs.\n3) Observe experiments designed for study of effects of drugs.\n4) Critically evaluate drug formulations and be able to interpret the clinical pharmacology of marketed preparations commonly used in dentistry.\n126.96.36.199- SEMESTER I:\n1. General Pharmacology:\na. Definition of drug and drug nomenclature.\nb. Branches / Divisions of Pharmacology\nc. Active principles of drug and Pharmacology\nd. Dosage forms and doses of drugs.\ne. Absorption of drugs and processes involved in drug absorption\nf. Factors modifying absorption of drugs.\ng. Transport of drugs across cell-membrane\nh. Bioavailability, its clinical significance and factors affecting bioavailabiliy\ni. Drugs reservoirs, distribution and redistribution of drugs, plasma protein binding.\nj. Pro-drug, Biotransformation of drugs, enzyme induction, enzyme inhibition and entero-hepatic circulation\nk. Plasma half-life of drugs, steady state concentration, its clinical mportance and factors affecting it.\nl. Excretion of drugs.\nm. Mechanism of drug action.\nn. Dose response curves, structure-activity relationship.\no. Factors modifying action and doses of drugss.\np. Pharmacokinetics, pharmacodynamics and Receptors\n2. Drugs Acting on Autonomic Nervous system\n• Cholinimimetic Alkaloids\n• Anti Muscarinic\n• Non catecholamine\nAnti- Cholinergic Drugs\n• Anti Muscarinic\n• Non catecholamine\nSympatholytics / Antiadrenergics\n• Alpha Adrenergic Blockers\n• Beta Adrenergic receptor Blockers\n3. Autocoids and Anti-inflammatory Agents:\nIntroduction to anti-inflammatory agents and autocoids.\nIntroduction to diuretics and related agents\n5. Cardiovascular System:\nTreatment of Congestive Heart Failure & Cardiac Glycosides, Anti- Anginal agents, Anti Hypertensive, Anti Arrhythmic, Coagulation & Anti-coagulants, treatment of Anemia, treatment of Hyperlipidemia.\n6. Gout and Rheumatoid Arthritis\nTreatment of gout and rheumatoid arthritis\nIntroduction to non-narcotic analgesics\n1. Weight & Measures, Interconversion\n2. To prepare & Dispense 90 ml of 0.05% KmnO4 solution.\n3. To prepare & dispense 120 ml of 1:4000 KMnO4 solution\n4. To prepare & dispense 100 ml of .01% KMnO4 from stock.\n5. To prepare and dispense 90 ml of Carminative Mixture.\n6. To prepare and dispense 3 doses of Bismuth Kaolin\n7. To prepare & dispense 90 ml Castor Oil Emulsion. Each 30 ml Contains 4 ml of Oil.\n188.8.131.52- SEMESTER II\nIntroduction, Antiseptics & Disinfectants, Folate Antagonists, Penicillin, Cephalosporins, Macrolides, Quinolones, Tetracyclines, Chloramphenicol, Aminoglycosides, Anti-Tuberculous. Antiviral agents\nCentral Nervous System:\nTreatment of Parkinsonism, Epilepsy, CNS Stimulants, Antipsychotics, Antidepressants, Opioid Analgesics, General Anesthetics, Local Anesthetics, Sedative Hypnotics, Anxiolytics, Treatment of migraine\nDescription of pharmacological agents used in the treatment of respiratory disorders.\nDescription of pharmacological agents used in the treatment of gastrointestinal disorders.\nDescription of Anti-protozoal agents, Anti-Helminthic agents,\nIntroduction, Pituitary and Hypothalamus, Thyroid & Antithyroid Drugs, Insulin & Oral, Hypoglycemics, Paratharmone & Calcitonin, Androgens, Female sex Hormones & Anti-Estrogens, Corticosteroids.\nAnti – septics, astrigents, obtundents, mummifying agents, bleaching agents, styptics, disclosing agents, dentifrices, mouth washes, caries and fluorides. 2. Pharmacotherapy of common oral conditions in dentistry\na. To prepare & dispense 90 ml Cod Liver Oil Emulsion. Each 30 ml containing 4 ml Oil.\nb. To prepare & dispense 40 ml of Calamine Lotion.\nc. To prepare and dispense 20 ml of Turpentine Liniment\nd. To prepare & dispense 4 powders of Atropine diphenoxylate.\ne. To prepare & dispense 4 powders, each containing 0.6 mg Hyoscine.\nf. To prepare & dispense 15G of Sulphur Ointment.\ng. Prescription Writing\n184.108.40.206- RECOMMENDED BOOK:\n• Bertam G Katzung, Basic and Clinical pharmacology\n• Review of Pharmacology Katzung\n• Lauerence D.R. Clinical Pharmacology 8th ed. Churchill Livingstone\n• Lippincott’s Illustrated Reviews Pharmacology\n• Basis of therapeutics and pharmacology Goodman Gillmans\n2.2.4- ORAL BIOLOGY\nOral Biology course includes instructions in the subject of Dental Morphology, Oral Embryology, Oral Histology and Oral Physiology.Introduction – Oral Biology – a composite of basic Dental Sciences & their clinical applications.\nThe student should acquire basic skills in :\n1. Carving of crowns of permanent teeth in wax.\n2. Microscopic study of Oral tissues.\n3. Identification of Deciduous & Permanent teeth.\n4. Age estimation by patterns of teeth eruption from plaster casts of different age groups.\nAfter a course on Oral Biology,\n1. The student is expected to appreciate the normal development, morphology, structure & functions of oral tissues & variations in different pathological/non-pathological states.\n2. The student should understand the histological basis of various dental treatment procedures and physiologic ageing process in the dental tissues.\n3. The students must know the basic knowledge of various research methodologies.\n220.127.116.11- SEMESTER I:\nI. TOOTH MORPHOLOGY\n1. Introduction to tooth morphology:\nHuman dentition, types of teeth, & functions, Palmer’s & Binomial notation systems, tooth surfaces, their junctions – line angles & point angles, definition of terms used in dental morphology, geometric concepts in tooth morphology, contact areas & embrasures – Clinical significance.\n2. Morphology of permanent teeth :\n• Description of individual teeth, along with their endodontic anatomy & including a note on their chronology of development, differences between similar class of teeth & identification of individual teeth.\n• Variations & Anomalies commonly seen in individual teeth.\n3. Morphology of Deciduous teeth :\n• Generalized differences between Deciduous & Permanent teeth.\n• Description of individual deciduous teeth, including their chronology of development, endodontic anatomy, differences between similar class of teeth & identification of individual teeth.\n4. Occlusion :\n• . Definition, factors influencing occlusion – basal bone, arch, individual teeth, external & internal forces & sequence of eruption.\n• . Inclination of individual teeth – compensatory curves.\n• . Centric relation & Centric occlusion – protrusive, retrusive & lateral occlusion.\n• . Clinical significance of normal occlusion.\n• . Introduction to & Classification of Malocclusion.\nII. ORAL EMBRYOLOGY\n• General human development\n• The brachial apparatus\n• Development of face/tongue/thyroid gland\n• Development of nasomaxillary complex\n• Development of palate\n• Development of mandible and temporo mandibular joint\n• Development of para-nasal sinuses\n• Development of salivary glands\n• Tooth development and its associated structures\n• Development of cartilages and bones of facial skeleton\n• Introduction of clinical anomalies related with all the above topics\n• Introduction to Post natal facial growth.\n• Development of base of skull\nIII. ORAL HISTOLOGY\n• Bone/cartilage (specially jaws)\n• Alveolar bone\n• Periodontal ligament\n• Tooth eruption and shedding\nIV. ORAL PHYSIOLOGY\n1. Saliva :\nComposition of saliva – variations, formation of saliva & mechanisms of secretion, salivary reflexes, brief review of secretomotor pathway, functions, role of saliva in dental caries & applied aspects of hyper & hypo salivation.\n2. Mastication :\nMasticatory force & its measurement – need for mastication, peculiarities of masticatory muscles, masticatory cycle, masticatory reflexes & neural control of mastication.\n3. Deglutition :\n. Review of the steps in deglutition, swallowing in infants, neural control of deglutition & dysphagia\n18.104.22.168- SEMESTER II\nIII. ORAL HISTOLOGY\n1. Oral mucous membrane\n5. Temporo-mandibular joint clinical consideration\n6. Endogenous implants/changes during tooth movement/wound healing\n7. Detailed microscopic study of Oral Mucosa, variation in structure in relation to functional requirements, mechanisms of keratinization, clinical parts of gingiva\n8. Dentogingival & Mucocutaneous junctions & lingual papillae. Age changes & clinical considerations.\n9. Salivary Glands :\na. . Detailed microscopic study of acini & ductal system.\nb. . Age changes& clinical considerations.\n10. TM Joint :\na. . Review of basic anatomical aspects & microscopiuc study & clinical considerations.\n11. Maxillary Sinus :\na. Microscopic study, anatomical variations, functions & clinical relevance of maxillary sinus in dental practice.\n12. Processing of Hard & soft tissues for microscopic study :\ni. . Ground sections, decalcified sections & routine staining procedures.\n13. Basic histochemical staining patterns of oral tissues.\nIV. ORAL PHYSIOLOGY\n1. Calcium, Phosphorous & fluoride metabolism :\n. Source, requirements, absorption, distribution, functions & excretion, clinical considerations, hypo & hypercalcemia & hyper & hypo phosphatemia & fluorosis.\n2. Theories of Mineralization :\nDefinition, mechanisms, theories & their drawbacks.\nApplied aspects of physiology of mineralization, pathological considerations – calculus\n3. Physiology of Taste :\nInnervation of taste buds & taste pathway, physiologic basis of taste sensation, age\nchanges & applied aspects – taste disorders.\n4. Physiology of Speech :\nReview of basic anatomy of larynx & vocal cords.\n.Voice production, resonators, production of vowels & different consonants – Role of palate, teeth & tongue.\nEffects of dental prosthesis & appliances on speech & basic speech disorders.\n• Tooth carving with proper dimensions on a wax.\n• Histological slides.\n22.214.171.124- RECOMMENDED TEXT BOOKS\n• Oral Histology (Development, Structure and Function), A.R.Tencate\n• Orban’s Oral Histology & Embryology – S.N.Bhaskar\n• Oral Development & Histology – James & Avery\n• Wheeler’s Dental Anatomy, Physiology & Occlusion – Major.M.Ash\n• Dental Anatomy – its relevance to dentistry – Woelfel & Scheid\n• Applied Physiology of the mouth – Lavelle\n• Physiology & Biochemistry of the mouth – Jenkins\n• 2.2.5- Community Dentistry\nTo prevent and control oral diseases and promote oral health through organized community efforts\nAt the conclusion of the course the student shall have a knowledge of the basis of public health, preventive dentistry, public health problems in India, Nutrition, Environment and their role in health, basics of dental statistics, epidemiological methods, National oral health policy with emphasis on oral health policy.\nB). Skill and Attitude:\nAt the conclusion of the course the students shall have require at the skill of identifying health problems affecting the society, conducting health surveys, conducting health education classes and deciding health strategies. Students should develop a positive attitude towards the problems of the society and must take responsibilities in providing health.\nC). Communication abilities:\nAt the conclusions of the course the student should be able to communicate the needs of the community efficiently, inform the society of all the recent methodologies in preventing oral disease\n126.96.36.199- SEMESTER I\n1. Concepts of Health and Disease\nConcepts of Health Disease and Illness, Determinants of Health, Primary Health Care Activity and Underlying Principals, Global Goals for Oral Health for the Year 2000, Criteria for A Public Health Problem and Public Health Importance of Oral Disease, Impact of Oral Disease with reference to Impairment Functional Limitation, Discomfort Disability and Handicap.\n2. Principles of epidemiology\nEpidemeology, Uses of Epidemeology, Types of Epidemeological Studies, Indices – Criteria for an Ideal Index. Protocol to conduct an Epidemiological Survey.\n3. Dental Caries\nEtiology and Nature of Dental Caries Methods of Diagnosis Caries, used in Epidemiology DMFT & DMFS limitation of DMFS, WHO Criteria for diagnosing Dental Caries and Criteria for Treatment need.\n4. Periodontal Disease\nEtiology and Natural History of Periodontal Disease continuous disease Model and Burs Model of Progression of Periodontal disease what Epidemeology has revealed about periodontal disease name of Indices used to Measure Periodontal Disease and Periodontal Treatment need short coming of Russel Perio Index, Ramfjord Perio disease indices, codes, dean’s index for fluorosis WHO indices for malocclusion for TMJ disorders lesions of Oral Mucosa and bone.\n5. Dental Disease and Fluoride\nSampling types of sampling fluoride. Mode of action of fluoride sources and metabolism or fluoride historical back ground of water fluoridation, Fluoridation studies, advantages and disadvantages of water fluoridation, alternative methods to water fluoridation.\n188.8.131.52- SEMESTER II\n1. Surveys and Screening\nScreening, aim and principles of screening difference between screening & epidemiological surveys validity, sensitivity +ve and –ve predictive value, Clinical trials various steps in conducting a clinical trial.\n2. Prevention of Dental Disease\nTrends in dental caries in developed and under developing countries, Studies showing correlation between sugar and dental caries, High risk markers of caries, Fissure sealant, rationale for used cost effectiveness, cost benefit, Strategy is to reduce sugar consumption in a community.\n3. Health Promotion\nDescription of Health promotion & various types of Health Promotion Activities.\nStatistics types of means median mode weighted mean variance, standard normal deviates, sampling error probability.\n5. Dental Auxiliaries\nDental and non-dental auxiliaries, classification problems with dental care in developing countries. Uses of Health auxiliaries to provide a comprehensive O~ essential dental care to rural community.\n6. Health Education\nDescription of Health education and principles followed to plan a dental health education program.\nPractical & field assignments:\nA. Clinical Oral Examination\ni Exercise on Models and Extracted teeth\nii Exercise on patients in out patients department\niii Examination of institutionalized population like school children\nB. Questionnaire / interview study\ni Designing a questionnaire\nii. Pilot testing the questionnaire\niii Data coding, processing and analysis\nC. Planning and conducting a dental health education (D.H.E.) session:\ni. Designing D.H.E. material\nii Planning, conducting and evaluating (D.H.E) sessions\nD. Chairside preventive dental procedures\ni High fluoride gel application\nii Fissure sealing\niv Plaque disclosing\nv Instructions about Oral Hygiene measures\n• Tooth Brushing demonstration\n• Inter-dental cleaning\n• Chemical control of dental plaque\n184.108.40.206- RECOMMENDED BOOKS:\nCommunity Dentistry By Brian Burt\n2.2.6- PRE CLINICAL DENTISTRY\nThe preclinical dentistry include the following: –\n1. Junior Operative Techniques\n2. Junior Prosthetic Techniques\n3. Orthodontics Laboratory Procedures\n1. Junior Operative Techniques\ni. Introduction to dental operatory\nii. Introduction to instrument used in cavity preparation\niii. Classification of dental caries\niv. Principles of Cavity preparation\nv. Cavity preparation on plaster models/phantom head\nvi. Filling Materials\n1. Identification and study of handcutting instruments chisles, gingival margin trimmers, excavators and hatchet.\n2. Identification and use of rotary cutting instruments in contra angle hand pieces burs (Micromotor)\n3. Exercises on phantom head models which includes cavity preparation base and varnish application matrix and wedge placement followed by amalgam restoration\na. Class I (5)\nb. Class I with extension (2)\nc. Class II (10)\nd. Class II Mods (2)\ne. Class V and III for glass ionmers (4)\nf. Class V for amalgam (2)\n4. Polishing of above restorations.\n5. Demonstration of Class III and Class V cavity preparation. For composites on extracted tooth completing the restoration.\n6. Polishing and finishing of the restoration of composites.\n7. Identification and manipulation of varnish bases like Zinc Phosphate, Poly carboxylate, Glass Ionomers, Zinc Oxide, Eugenol cements.\n8. Identification and manipulation of various matrices tooth separators and materials like composites and modified glass ionomer cements.\n2. Junior Prosthetics Techniques:\nI. Introduction of impression and denture materials\nII. Laboratory procedures\na) Complete Dentures\nb) Arylic removeable partial denture\nc) Cast partial denture\nd) Anterior crowns\ne) Posterior crowns\ng) Relining / Rebasing procedures\ni) Soldering and welding techniques.\n3. Orthodontics Laboratory Procedures\ni. Properties of wires used in Orthodontics\nii. Principles of wire bending including wire bending on wooden blocks\n2.2- Second Professional B.D.S:", "label": "Yes"}
{"text": "Type 2 diabetes results when the body is unable to produce the amount of insulin it needs to convert food into energy or when it is unable to use insulin appropriately. Sometimes the body is actually producing more insulin than is needed by a person to keep blood glucose in a normal range. Yet blood glucose remains high, because the body's cells are resistant to the effects of insulin. Physicians and scientists believe that type 2 diabetes is caused by many factors, including insufficient insulin and insulin resistance. They increasingly believe that the relative contribution each factor makes toward causing diabetes varies from person to person.\nKelly Prinkey-Krupinski, 48 and an avid dog lover, has been struggling with adult onset Type 1 diabetes for 12 years. She said the disease runs her life. “It is a constant struggle,” she said. “My mind is always aware that every bite of food that I eat, every medicine I take, every illness and emotion I experience will affect my blood sugar. There is never a vacation from the constant balancing act to stay alive. It scares me to think of a time when I can't obtain the insulin that I must take 24-7. I would pray that there will be a cure in my lifetime. I just hate to think of the kids that struggle with Type 1 diabetes. This research with dogs sounds promising. As a dog lover myself, I would love to see if our canine friends can be cured. I'm excited to see the results.”\nYuri Elkaim is one of the world’s most trusted health and fitness experts. A former pro soccer player turned NYT bestselling author of The All-Day Energy Diet and The All-Day Fat Burning Diet, his clear, science-backed advice has transformed the lives of more than 500,000 men and women and he’s on a mission to help 100 million people by 2040. Read his inspiring story, “From Soccer to Bed to No Hair on My Head” that started it all.\ni want to use this means to thank Dr.obor for getting me cured from deadly disease which almost took my life,i have been suffering for genital for genital herpes since 2014,and take different drugs and non could get me cured,i keep wasting money on drugs till i contacted dr.obor who get me cured with his herbal medicine and make some gain back my life, i cant talk less of you sir, you are indeed a great man and i thank you for everything you have done in my life, i also want to tell everyone reading this and suffering from this disease to contact dr.obor on his email firstname.lastname@example.org and i promised you will testify also.\nSulfonylureas stimulate the beta cells of the pancreas to release more insulin. Sulfonylurea drugs have been in use since the 1950s. Chlorpropamide (Diabinese) is the only first-generation sulfonylurea still in use today. The second generation sulfonylureas are used in smaller doses than the first-generation drugs. There are three second-generation drugs: glimepiride (Amaryl), glipizide (Glucotrol and Glucotrol XL), and glyburide (Micronase, Glynase, and Diabeta). These drugs are generally taken one to two times a day, before meals. All sulfonylurea drugs have similar effects on blood glucose levels, but they differ in side effects, how often they are taken, and interactions with other drugs.\nDr. Fung says he decided to experiment with intermittent fasting because he was frustrated seeing so many diabetic patients with kidney failure. “It occurred to me that fasting was an underutilized therapeutic option for losing weight,” he recalls. “I started doing this five years ago, and a lot of people got incredibly good results – it reversed their diabetes.”\nTCM views the human body and its functioning in a holistic way. From this perspective, no single body part or symptom can be understood apart from its relation to the whole. Unlike Western medicine, which seeks to uncover a distinct entity or causative factor for a particular illness, TCM looks at patterns of disharmony, which include all presenting signs and symptoms as well as patients’ emotional and psychological responses. Humans are viewed both as a reflection of and as an integral part of nature, and health results from maintaining harmony and balance within the body and between the body and nature.3\nWithin the model of Five Phases, each element is associated with an organ. Wood is associated with the liver, fire with the heart, earth with the spleen-pancreas-stomach, metal with the lungs, and water with the kidneys. In addition, other phenomena, such as seasons, cardinal directions, weather, color, and emotions, are associated with each element. Within the TCM model, diagnostic information is gained by finding out patients’ favorite season, color, and predominant emotion(s).\nComplications, which eventually lead to death, usually arise when the patient does not adhere to the advice of their doctor. Statistics show that sixty percent of patients are able to live long and productive lives; the rest suffer from a lot of complications including retinopathy (eye disease which can lead to blindness), gastroparesis (inability of the stomach to move food), neuropathy, and end-stage renal disease to name a few.\nThe blood glucose level is the amount of glucose in the blood. Glucose is the main source of energy for the body's cells and is carried to them through the bloodstream. The hormone insulin allows the glucose to get into the cells. In type 1 diabetes, the body can no longer make insulin, so the glucose can't get into the body's cells. This makes the blood glucose level rise.\nGlycated hemoglobin (A1C) test. This blood test indicates your average blood sugar level for the past two to three months. It measures the percentage of blood sugar attached to hemoglobin, the oxygen-carrying protein in red blood cells. The higher your blood sugar levels, the more hemoglobin you'll have with sugar attached. An A1C level of 6.5 percent or higher on two separate tests indicates you have diabetes. A result between 5.7 and 6.4 percent is considered prediabetes, which indicates a high risk of developing diabetes. Normal levels are below 5.7 percent.\nThe theory of Five Phases, Wu Xing, is a means of classifying phenomena in terms of five basic processes represented by the elements wood, fire, earth, metal, and water. There exists a dynamic balance and relationship among the elements such that if the balance is interrupted or destroyed, pathological changes may occur. The clockwise movement of one element into the next (wood, fire, earth, and so forth) whereby one element generates, acts on, or promotes the following element, is referred to as the Sheng cycle. The Ke cycle represents an element acting on or controlling another element in a different order (Figure 2).3\nDiabetes is a disease characterized by a person’s inability to process carbohydrates, a condition that if untreated can lead to often-catastrophic health consequences: lethargy, diminished eyesight, heart attacks, strokes, blindness and a loss of circulation in the feet that could lead to amputation. The Centers for Disease Control and Prevention estimate that in 2014, about 29 million Americans – almost 1 in 10 – had diabetes.\nMilk thistle is an herb that has been used since ancient times for many different ailments and is considered a tonic for the liver. The most studied extract from milk thistle is called silymarin, which is a compound that has antioxidant and anti-inflammatory properties. It is these properties that may make milk thistle a great herb for people with diabetes.\n8. Amylin Mimetic This type of medication stimulates the release of insulin, and is used along with insulin injections. It may also help suppress hunger and promote weight loss. It’s less commonly used because it’s a shot administered in addition to insulin at each meal. Side effects can include low blood sugar, nausea, vomiting, headache, and redness and irritation at the injection site. Symlin (ramlintide) is what your doctor will prescribe you.\nIn type 2 diabetes, even though insulin resistance is what leads to the condition, injections of insulin are not the first resort. Instead, other drugs are used to help boost insulin production and the body’s regulation of it. Insulin resistance occurs when the body’s cells don’t respond properly to insulin, which is a hormone made in the pancreas that’s responsible for ferrying glucose to cells for energy.\nHow long will diabetes stay away after weight loss? Long-term normal blood glucose control in previously diabetic individuals after bariatric surgery demonstrates that diabetes does not recur for up to 10 years, unless substantial weight gain occurs (86). These observations are consistent with the twin cycle hypothesis and the existence of a trigger level for adverse metabolic effects of fat in the pancreas. Hence, for a given individual with type 2 diabetes, reducing the liver and pancreas fat content below his or her personal trigger levels would be expected to result in a release from the fatty acid–mediated dysfunction. Individual tolerance of different degrees of fat exposure vary, and understanding this liposusceptibility will underpin the future understanding of genetically determined risk in any given environment. However, this should not obscure the central point: If a person has type 2 diabetes, there is more fat in the liver and pancreas than he or she can cope with.\nOne of the biggest hits in type 2 diabetes treatment is glucagon-like peptide (GLP)-1 receptor agonists, which induce insulin production in beta-pancreatic cells while suppressing the secretion of glucagon. All big pharma have GLP-1 drugs on the market or their pipelines, including Sanofi, Eli Lilly, Roche, AstraZeneca and Boehringer Ingelheim. But Novo Nordisk is going a step further with the first oral version of a GLP-1 drug, which is now close to the market.", "label": "Yes"}
{"text": "A tan has the ability to significantly reduce facial inflammation. Can you consider someone with positive red checks may realize this? Amazing? Unbelievable? Pale individuals typically lack melanocyte hormone. Melanotan has the ability to be able to stimulate melanin/melanocytes inside everyone who is not real albino… hiding a moderate flush below a tan. Again, this works within all types of epidermis down to probably the most porcelain white pores and skin.\nWhen studied, melanotan users epidermal width increased significantly. In rosacea sufferers the epidermis could be half that of typical subjects; thus doubling or tripling typically the thickness of the epidermis should become extremely useful to rosacea sufferers.\nMelanotan employ will be employed by many rosacea sufferers as it thickens the skin considerably (up to 300%), in addition to has an anti-inflammatory effect throughout the skin and top portion of the dermis. Furthermore, it shields blood vessels plus pain nerves via a much stronger in addition to thicker epidermis — this will minimize rosacea symptoms in addition to triggers!\nProduction associated with melanin thickens the epidermis, absorbs light rays from the sun and absorbs heat from the external environment. Thus rosacea blood vessels and annoyed nerves will not necessarily “see” multiple insults as the skin will repel or perhaps absorb rosacea activates. It is germane to make note of that rosacea sufferers are usually caught within a get 22 because they are advised to avoid the sun and wear sunscreen (wise advice)… however this results inside a thinner, weakened epidermis. Melanotan retains the potential to help fortify our main barrier. Not really a treatment, but something in order to be aware of indeed.\nThe minimal side effects associated with Melanotan One use are appreciated by simply users. Melanotan A single does not combination the blood brain buffer (BBB). For this specific reason this égal has continued trials. Cyclic analogues (MT-II) have a broad range of peripheral effects and systemic control are always gonna pose problem in clinical employ (weight loss, sexual desire, appetite suppression). Developers would become facing an almost impossible mission got they decided to create MT-II and place just before regulatory authorities regarding approval. Sides effects are more prevalent in Melanotan 2 users. However, the majority of choose Melanotan 2 over Melanotan A single because it is a better benefit, tans more efficiently/effectively, effects the sexual desire, etc. Across typically the board, MT-II is usually superior to Melanotan One when that comes to photoprotection and tanning. Furthermore MT-II has been shown with an effect on body composition via the melanocortin system.\nMelanotan One’s peptide structure will be very closely matched up to alpha-melanocyte revitalizing hormone (? -MSH). It specifically targets the melanocortin-1 receptor (MC1R) the industry individual receptor accountable for epidermis color. MT-II, on the other hand, is a reduced protein sequence which often effects a selection of melanocortin pain (MC1R, MC3R, MC4R & MC5R). This specific ‘shotgun effect’ agonism of the complete spectrum of pain results in outcomes that are only witnessed from MT-II. Most notably, increases within sexual arousal that are due to MC3R & MC4R activation. Melanocortin receptors display tissue-specific expression styles, as well because different binding affinities. The central melanocortin system plays a new fundamental role within the control associated with feeding and body weight. Melanotan One users want lowest side and peripheral effects using a focus on photoprotection.\nMelanotan One has the half life that will lasts just moments in the body. www.blibrunutansol.bz is usually further reaching and lasts longer in the particular body. It had been recently found out there that the pituitary gland is not necessarily what exactly is responsible regarding a-MSH production, nevertheless the cites around the skin itself which often triggers the discharge. 1mg of possibly Melanotan One or even Melanotan II peptide is quite the super-physiological dose for that average caucasian. Melanotan One is typically the choice for refined results while Melanotan II may be the excellent peptide for Ashton kutcher and Barbie.", "label": "Yes"}
{"text": "In utero Exposure to β-2-Adrenergic Receptor Agonist Drugs and Risk for Autism Spectrum Disorders\nOBJECTIVES: The purpose of this study was to investigate associations between use of β-2-adrenergic receptor (B2AR) agonist drugs during pregnancy and risk for autism spectrum disorders (ASD).\nMETHODS: A case-control study was conducted by using Denmark’s health and population registers. Among children born between 1997 and 2006, 5200 cases with ASD admission diagnoses and 52 000 controls without ASD were identified and individually matched on month and year of birth. Conditional logistic regression models were used to estimate odds ratios (OR) and confidence intervals (CI) for any B2AR agonist exposure during pregnancy, preconception, and by trimester.\nRESULTS: In total, 3.7% of cases and 2.9% of controls were exposed to B2ARs during pregnancy. Use of B2ARs during pregnancy was associated with increased risk of ASD, even after adjustment for maternal asthma and other covariates (OR: 1.3, 95% CI: 1.1–1.5). The elevated risk was observed with use of B2AR during preconception (OR: 1.3, 95% CI: 1.0–1.6), first trimester (OR: 1.3, 95% CI: 1.1–1.5), second trimester (OR: 1.5, 95% CI: 1.1–1.7), and the third trimester (OR: 1.4, 95% CI: 1.1–1.7). There was some evidence that longer B2AR within-pregnancy use was associated with the increased risk.\nCONCLUSIONS: B2AR agonist exposure during pregnancy may be associated with an increased risk for ASD. If the effect is real, any intervention must be balanced against benefits of indicated medication use by pregnant women.\n- ASD —\n- autism spectrum disorders\n- B2AR —\n- β-2-adrenergic receptor\n- CD —\n- conception date\n- CI —\n- confidence interval\n- ICD —\n- International Classification of Diseases\n- OR —\n- odds ratio\nWhat’s Known on This Subject:\nCertain medications such as β-2 adrenergic receptor agonist drugs are known to cross the placenta and may affect developing neurons in the fetus. Only 1 epidemiologic study thus far has investigated this association.\nWhat This Study Adds:\nβ-2 adrenergic receptor agonist drug exposure during pregnancy may be associated with an increased risk for autism spectrum disorders. Results from this study add to the limited knowledge on prenatal pharmacological exposures as potential autism spectrum disorders risk factors.\nPrenatal pharmacologic exposures have been implicated as potential risk factors for autism spectrum disorders (ASD).1–3 In particular, concerns have been expressed that exposure to terbutaline, a β-2 adrenergic receptor (B2AR) agonist drug, used as indicated as an antiasthmatic4 and used off-label later in pregnancy as a tocolytic agent,5 may increase the risk for neurodevelopmental disorders in offspring.6–8 The prevalence of B2AR agonist drug exposure during pregnancy range from 1.0% to 7.5% in Denmark and throughout Europe.9–11 A study of in utero B2AR agonist drug exposure in a small series of dizygotic twin pairs suggested an increased risk associated with ASD.12 A case-control study of 291 cases and 284 controls found that exposure for more than 2 days during the third trimester was associated with increased risk for ASD, although estimates were imprecise (adjusted odds ratio [OR] 6.0, 95% confidence interval [CI] 1.1–34.3).13\nIt is unclear if the apparent effects are due to confounding by indication: whether it is the pharmacologic exposure or the indicating condition that increases risk to ASD. Long-acting B2AR agonist drugs such as salmeterol and formoterol are used to reduce asthma exacerbations and provide asthma control in adults.14 Croen et al observed that maternal diagnosis of asthma or allergies during the second trimester was associated with risk of ASD.15 However, Lyall et al reported no association of maternal asthma with child ASD.16\nThere is some mechanistic evidence to support the role of B2AR in development of ASD. β-2 adrenergic receptors within the catecholamine system are involved in normal nervous system development and the function of both neural and nonneural tissues in adults.17 The most common approach to treatment of asthma in Denmark is inhalation of B2AR agonist drugs18 and placental transfer of B2AR agonists has been demonstrated in vitro19 and indicated in vivo even at inhaled concentrations.20 B2AR agonist drugs used during pregnancy can affect the fetal brain by crossing the placenta, resulting in the disruption of either replication or differentiation of the developing neurons.21 The mechanisms within the mature β-2-adrenergic receptors protect against overstimulation; however, fetal receptors do not have the ability to regulate any imbalance and may in fact become sensitized.22 Early research has shown that B2AR agonist drugs administered to pregnant rats during gestation alters neural cell replication and differentiation, synaptogenesis, and expression of synaptic proteins involved in neurotransmission.23–25 Although animal studies support the biological plausibility of adverse effects associated with prenatal B2AR agonists drug exposure, the findings are not trimester specific and suggest that there may be multiple critical periods throughout early development.22,25,26 However, because uncontrolled asthma has been associated with poor birth outcomes, pregnant women are generally recommended to continue asthma medication.27,28 Given the biological plausibility and limited knowledge regarding risks of prenatal pharmacologic exposures, we conducted a population-based case-control study to estimate the associations of maternal exposure to B2AR agonist drugs used during preconception and pregnancy with the risk of delivering a child who goes on to develop ASD.\nThe Institutional Review Board of Drexel University and the Danish Data Protection Agency (Record No. 2010-41-4861) approved this study.\nAll children (n = 749 755) born in Denmark between January 1, 1997, and December 31, 2006, were identified through the Civil Registration System.29 Children were excluded if they could not be linked to their biological mother (n = 1139), if the biological mother did not live in Denmark a year before delivery (n = 10 806), or if the child was of gestational age <23 weeks or >43 weeks (n = 1774). Therefore, the study population (n = 628 408) was then drawn from all biological singletons; for women with multiple births, 1 child was randomly selected for inclusion in the study.\nCases were identified from the National Hospital Register and the Danish Psychiatric Central Register that includes information on all inpatient and outpatient care from psychiatric hospitals and psychiatric wards in general hospitals in Denmark.30 The quality of the diagnosis of childhood autism in the Denmark registers was evaluated through medical records review: register-based diagnosis of childhood autism was confirmed 94% of the time with an additional 3% falling within ASD.31 However, there is also a possibility for unregistered cases of ASD. Subjects’ records from January 1, 1999, to March 31, 2011, were searched for International Classification of Diseases, 10th Revision, codes (ICD-10) of F840, F841, F845, and F848/F849 (childhood autism, atypical autism, Asperger syndrome, and pervasive developmental disorder-unspecified, respectively). Subjects were considered a case if any of these codes were present.\nControls were defined as individuals without ASD admission diagnoses. Ten controls per case were individually matched on month and year of birth, assuring the same follow-up period for cases and controls, and thus the same opportunity to be diagnosed.\nPharmacologic exposure information was drawn from the Drug Prescription Register, which records all dispensed prescribed medication from any pharmacy, except hospital dispensaries in Denmark. Therefore, we were unable to capture B2AR agonist use as a tocolytic in the third trimester. The drug codes included in the exposure definition are R03AC02, R03AC03, R03AC04, R03AC05, R03AC12, R03AC13, R03CC02, R03CC03, and R03CC12. We extracted information regarding personal identification number, dispense date, drug code (the World Health Organization Anatomic Therapeutic Chemical classification system), name of drug, number of packaged dispensed, and the number of defined daily dosage per package.32 The exposure windows were defined as preconception (90 days before the estimated CD), first trimester (within 90 days after the estimated CD), second trimester (within 90–180 days after estimated CD), and third trimester (180 days after the estimated CD to delivery date). A child was considered exposed if the dispense date fell within the specified exposure period or the days supplied overlapped any portion of the exposure period or interest. Children born to women who did not fill a prescription for B2AR agonist drugs for the entire period from 90 days before estimated CD through the date of delivery were considered unexposed. To calculate duration of use, the number of defined daily dosages in each dispensed package for the period falling within a given exposure window, based on dispensed date, were summed. Duration was dichotomized into 2 categories representing use for more or less than half a trimester (1–45 days and ≥45 days) in each exposure window.\nCovariates were derived from available health registers and the social registers of Statistics Denmark. They included parental age, psychiatric history, mother’s number of live births, child’s gestational age, birth weight, obstetric complications, and family socioeconomic status (a combination of parental income and the highest level of education attained). Gestational age was given in days from self-reported last menstrual period and corrected using an ultrasound if the last menstrual period was uncertain. The variable for psychiatric history included schizophrenia-like psychosis (ICD, Eighth Revision [ICD-8]: 295, 297, 298.39, 301.83; ICD-10: F20–F25, F28–F29), affective disorder (ICD-8: 296, 298.09, 298.19, 300.4; ICD-10: F30–F39), substance abuse (ICD-8: 303, 304; ICD-10: F10–F19.9 excluding F1×0.0) and any other psychiatric disorders. These covariates were chosen a priori based on literature suggesting their role as risk factors for ASD.33–40 Inpatient and outpatient maternal asthma was identified using ICD-8 codes (493.00 [Asthma bronchiale], 493.01 [Status asthmaticus], 493.02 [Asthma bronchila cum rhinitide allergica], 493.08 [Asthma aliud definitum], and 493.09 [Asthma]) and ICD-10 codes (J45 [Asthma], J45.0 [Asthma bronchilae allergicum], J45.1 [Asthma bronchiale non allergicum], J45.8 [Mixed asthma], J45.9 [Asthma without specification], J46 [Status asthmaticus], and J46.9 [Status asthmaticus]) present in the register at any time before the delivery of the child.\nConditional logistic regression analysis estimated associations of maternal B2AR agonist drug exposure variables with the children’s ASD diagnoses. Because none of the covariates resulted in a ≥10% change in unadjusted log ORs when added individually, both parental age and gender of the child were forced in all adjusted models as covariates. Parental age and gender have been associated with ASD in other studies and provided a reasonable alternative to the unadjusted model. To address confounding by indication, we included maternal asthma as a covariate and additionally restricted sample to mothers with a history of asthma.\nWe performed a sensitivity analysis to explore the potential impact of underreporting of B2AR use and maternal asthma in the register.41 Following previous analyses,41,42 we reestimated effect estimates under plausible sensitivity and specificity for both B2AR use and maternal asthma diagnosis. Specifically, for B2AR use we simulated B2AR use at 4%, a rate observed in other Nordic countries.43 Because we hypothesized that possible misclassification was nondifferential by outcome, we assumed equal exposure measurement sensitivity and specificity among cases and controls at 0.73 and 1.0, respectively. We simulated an increase in asthma prevalence from the observed prevalence of 1.3% to a prevalence of 2%, the prevalence estimate suggested by a previous study9 of hospital data from the County of North Jutland in Denmark, also assuming that misclassification was nondifferential with respect to outcome. Specificity was assumed to be 1.0, and sensitivity was set to 0.66 to reflect the level of underreporting needed consistent with the assumed true asthma prevalence of 2%.\nChildren with ASD (n = 5200) were more likely than controls (n = 52 000) to be male, have a higher parental age, and have a mother with an asthma diagnosis before the birth of the child (Table 1). The frequency of B2AR agonist drug exposure in the pregnancy period was 3.7% (190) for cases and 2.9% (1489) in controls. In addition, there were 83 cases (1.6%) and 673 controls (1.3%) with mothers who had a diagnosis for asthma during the pregnancy period.\nWe found an increased risk with exposure to B2AR agonist drugs during pregnancy (OR 1.3; 95% CI: 1.1–1.5), after controlling for child birth year and month, gender of the child, and parental age (Table 2). Trimester-specific effect estimates were similar to each other. While attempting to account for confounding by indication, adjustment for maternal asthma did not substantively change effect estimates, as seen by comparing models 1 and 2 in Tables 2, 3, and 4. Analyses restricting to only 863 mothers who had a diagnosis of asthma (Table 4) suggested an increased risk on average, although the 95% CI around the odds ratio included the null (1.3; 95% CI: 0.8–2.1). Sensitivity analyses suggested that misclassification of B2AR exposure and asthma diagnosis did not greatly influence B2AR effect estimates, for example, upon simulating an increase in maternal asthma prevalence from the observed 1.3% to the posited 2%, the B2AR effect estimate became 1.2 (95% CI: 1.1–1.5; see Supplemental Appendix).\nThe duration of use was similar between cases and controls within each period (Table 1). In conditional logistic regression results (Table 3), the point estimates for the longer duration exposure category (>45 days) tended to be larger than that for the shorter duration exposure category (1–45 days) during the preconception and first and second trimesters periods. However, the confidence limits for longer duration exposure effects overlapped substantively with those for shorter duration exposure.\nOur results suggest that exposure to B2AR agonist during the prenatal period was associated with increase in risk for ASD compared with those who were unexposed. These findings are consistent with other epidemiologic evidence regarding in utero exposure to B2AR agonist drugs and risk for ASD.12,13 Our analyses using sample restriction and adjustment for maternal asthma suggest that maternal B2AR agonist drug use, independent of indication, was associated with increased risk of ASD. Findings here also did not offer strong evidence for a particular exposure vulnerability window. Similar elevated risk was observed across the first, second, and third trimester, and all effect estimates had overlapping confidence intervals.\nAs with a previous study,13 we observed elevated risk associated with the preconception as well as with prenatal exposure. The reasons, outside of chance, for a preconception association could include the following: misattribution of early prenatal exposure to the preconception window, existence of some mechanism such as cellular reprogramming6 for persistence of effect into the prenatal period (outside of bioaccumulation because B2AR agonist drugs have half-life of <7 hours44), or imperfect confounder control. In addition, epidemiologic studies thus far that have looked at duration of B2AR use report the highest risk with prolonged use (>2 days),13 which is also consistent with our findings, although our definition of duration differed from that used previously.\nThere was a possibility for exposure and indication misclassification, although our sensitivity analysis did not suggest this substantively influenced in the B2AR effect estimates. Analyses also assumed that the mothers used all prescribed medication, but we have no information of when the prescribed medication was taken. Therefore, it is possible that portions of prescriptions during the study period were unused (leading to us overestimate of exposure) or that mothers used B2AR agonist drugs prescribed before the preconception period or during a previous trimester (leading to underestimate of exposure). Overestimation of the exposure could lead to an underestimate of effect estimate; however, we would expect this to be consistent throughout each exposure window. The impact of exposure misclassification is not possible to predict a priori in this setting.\nOur exposure data were restricted to only outpatient prescriptions. Therefore, we did not have information on in-hospital use of B2AR agonist drugs, which limits our ability to study maternal B2AR agonist drugs used as a tocolytic because inpatient prescription is most common. Although most prescriptions for B2AR agonist drugs including those used for asthma indications are obtained in an outpatient setting, these drugs are also prescribed as a tocolytic for in-hospital use. B2AR agonist drug exposure due to tocolytic use would most likely occur in the third trimester. Therefore, if a B2AR agonist like terbutaline is administered as a tocolytic and this does, as previously reported,13 increase ASD risk, our estimates of third trimester associations may in fact underestimate the true association. Our findings on outpatient exposure in the third trimester were consistent with those of Croen et al, who considered both inpatient and outpatient exposure and also observed a third trimester association.13\nAs with most observational epidemiology, unmeasured confounding is a potential limitation. We were able to adjust for numerous covariates that were available in the Danish register. However, potential confounders not represented in the register include in-home environmental exposures and pollutants, which may be associated with ASD45 but are unlikely to be strongly associated with medication use.\nAlthough our results add to the limited knowledge on prenatal pharmacological exposures as potential ASD risk factors and suggest further consideration of other exposures and vulnerabilities that share mechanistic similarities with B2AR agonists, one must be cautious when considering the public health implications of our current work. Under the assumptions that the association we observed is causal and precisely calculated, we estimate that <1% of ASD cases in the population can be attributed to prenatal B2AR agonists drug exposure (the population attributable fraction46 for any B2AR agonists exposure estimated based on an OR of 1.3 and the 2.9% observed exposure prevalence). Given this, with respect to individual decisions regarding B2AR agonist drug use during pregnancy, because uncontrolled asthma in pregnancy has been associated with poor birth outcomes,28,47 any potential modestly increased ASD risk needs to be carefully balanced against the established benefits of indicated medication use.\nWe thank Karyn Heavner, PhD, for assisting with data management and implementation of Monte Carlo simulations.\n- Accepted October 28, 2015.\n- Address correspondence to Nicole Gidaya, PhD, A.J. Drexel Autism Institute, Drexel University, 3020 Market St, Suite 560, Philadelphia, PA 19104. E-mail:\nFINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.\nFUNDING: Fees to access data from Denmark’s nation registers were funded by Drexel University Department of Epidemiology and Biostatistics to Dr Newschaffer. Dr Gidaya’s travel to Denmark was supported by Drexel University Student Travel Subsidy grant.\nPOTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.\n- Dean JC,\n- Hailey H,\n- Moore SJ,\n- Lloyd DJ,\n- Turnpenny PD,\n- Little J\n- Henry A,\n- Kennedy D,\n- Lowe S.\n- Tata LJ,\n- Lewis SA,\n- McKeever TM, et al\n- Connors SL,\n- Crowell DE,\n- Eberhart CG, et al\n- Rhodes MC,\n- Seidler FJ,\n- Abdel-Rahman A, et al\n- Pedersen CB\n- Lee D,\n- Majumdar SR,\n- Lipton HL,\n- Soumerai SB,\n- Hennessy S,\n- Davis RL\n- Atladóttir HO,\n- Pedersen MG,\n- Thorsen P, et al\n- Schendel D,\n- Bhasin TK\n- Larsson HJ,\n- Eaton WW,\n- Madsen KM,\n- Vestergaard M,\n- Olesen AV,\n- Agerbo E, et al.\n- Hanley JA\n- Bakhireva LN,\n- Schatz M,\n- Jones KL,\n- Chambers CD; Organization of Teratology Information Specialists Collaborative Research Group\n- Copyright © 2016 by the American Academy of Pediatrics", "label": "Yes"}
{"text": "- Is it a good sign when coughing up thick mucus?\n- Is Honey Good for mucus?\n- How can I remove fluid from my lungs at home?\n- What causes mucus in your nose?\n- How can I unblock my nose naturally?\n- What foods kill mucus?\n- What is the best position to sleep when you have a stuffy nose?\n- How do you sleep with a blocked nose?\n- How long does a blocked nose last?\n- Will my cold last longer if I swallow mucus?\n- How long does coughing up phlegm last?\n- What can I drink to cleanse my lungs?\n- How can I clear mucus from my nose?\n- What is the fastest way to get mucus out of your lungs?\n- Should you spit out phlegm?\n- What is the difference between phlegm and mucus?\n- What color mucus is bad?\nIs it a good sign when coughing up thick mucus?\nWhen you cough up thick, solid white mucus, it might be a signal that you have a bacterial infection in your airways.\nThis type of an infection could require prescription antibiotics from your doctor..\nIs Honey Good for mucus?\nTo provide relief, you need a mucus substitute and honey is ideal. Honey is sticky and thick, providing a protective membrane over the mucous membranes. Honey has natural anti-bacterial properties and contains an enzyme that converts into hydrogen peroxide when combined with salt and water.\nHow can I remove fluid from my lungs at home?\nWays to clear the lungsSteam therapy. Steam therapy, or steam inhalation, involves inhaling water vapor to open the airways and help the lungs drain mucus. … Controlled coughing. … Drain mucus from the lungs. … Exercise. … Green tea. … Anti-inflammatory foods. … Chest percussion.\nWhat causes mucus in your nose?\nBacterial and viral infections cause your nose and sinuses to produce excess mucus. This extra mucus attempts to flush out the bacteria that’s causing the infection as your body fights it off. Sometimes mucus becomes yellow or green as your body attempts to trap the infection, producing pus.\nHow can I unblock my nose naturally?\nHere are eight things you can do now to feel and breathe better.Use a humidifier. A humidifier provides a quick, easy way to reduce sinus pain and relieve a stuffy nose. … Take a shower. … Stay hydrated. … Use a saline spray. … Drain your sinuses. … Use a warm compress. … Try decongestants. … Take antihistamines or allergy medicine.\nWhat foods kill mucus?\n6 foods to eliminate excess mucus as suggested by Luke CoutinhoGinger. Ginger can be used as a natural decongestant and antihistamine. … Cayenne pepper. Excessive cough and mucus can be eliminated with the help of cayenne pepper. … Garlic. … Pineapple.\nWhat is the best position to sleep when you have a stuffy nose?\nTo sleep with a stuffy nose, you should be propped up on your back with a pillow to help the mucus drain out. You should avoid sleeping on your side, since it may make one or both nostrils even more congested.\nHow do you sleep with a blocked nose?\nWhat to do right before bedTake an antihistamine. … Diffuse an essential oil in your bedroom. … Use a humidifier in your bedroom. … Keep your bedroom cool and dark. … Apply a nasal strip. … Apply an essential oil chest rub. … Apply a menthol chest rub. … Prop up your head so you remain elevated.\nHow long does a blocked nose last?\nAlthough it might feel like longer, nasal congestion usually lasts around five to 10 days, depending on whether it is caused by a viral or bacterial infection. While decongestants can help to manage your nasal congestion symptoms, it is best to just let nasal congestion run its course.\nWill my cold last longer if I swallow mucus?\nSo, to answer your questions: The phlegm itself isn’t toxic or harmful to swallow. Once swallowed, it’s digested and absorbed. It isn’t recycled intact; your body makes more in the lungs, nose and sinuses. It doesn’t prolong your illness or lead to infection or complications in other parts of your body.\nHow long does coughing up phlegm last?\nAcute bronchitis often develops three to four days after a cold or the flu. It may start with a dry cough, then after a few days the coughing spells may bring up mucus. Most people get over an acute bout of bronchitis in two to three weeks, although the cough can sometimes hang on for four weeks or more.\nWhat can I drink to cleanse my lungs?\nHere are a few detox drinks that can help improve your lungs and overall health during the winter season:Honey and hot water. This powerful drink can help detoxify the body and fight off the effects of pollutants. … Green tea. … Cinnamon water. … Ginger and turmeric drink. … Mulethi tea. … Apple, beetroot, carrot smoothie.\nHow can I clear mucus from my nose?\nHome TreatmentsUse a humidifier or vaporizer.Take long showers or breathe in steam from a pot of warm (but not too hot) water.Drink lots of fluids. … Use a nasal saline spray. … Try a Neti pot, nasal irrigator, or bulb syringe. … Place a warm, wet towel on your face. … Prop yourself up. … Avoid chlorinated pools.\nWhat is the fastest way to get mucus out of your lungs?\nHome remedies for mucus in the chestWarm fluids. Hot beverages can provide immediate and sustained relief from a mucus buildup in the chest. … Steam. Keeping the air moist can loosen mucus and reduce congestion and coughing. … Saltwater. … Honey. … Foods and herbs. … Essential oils. … Elevate the head. … N-acetylcysteine (NAC)\nShould you spit out phlegm?\nIf your mucus is dry and you are having trouble coughing it up, you can do things like take a steamy shower or use a humidifier to wet and loosen the mucus. When you do cough up phlegm (another word for mucus) from your chest, Dr. Boucher says it really doesn’t matter if you spit it out or swallow it.\nWhat is the difference between phlegm and mucus?\nMucus is a thinner secretion from your nose and sinuses. Phlegm is thicker and is made by your throat and lungs.\nWhat color mucus is bad?\nRed or pink phlegm can be a more serious warning sign. Red or pink indicates that there is bleeding in the respiratory tract or lungs. Heavy coughing can cause bleeding by breaking the blood vessels in the lungs, leading to red phlegm. However, more serious conditions can also cause red or pink phlegm.", "label": "Yes"}
{"text": "In a new study from the British Antarctic Survey, scientists report that the Weddell Sea has lost one-third of its summer ice cover in the last five years. Summer sea ice has declined by one million square kilometers, an area twice the size of Spain, in the Weddell Sea along the coast of Antarctica.\nMany animals such as penguins and seals depend on the sea ice that surrounds Antarctica for finding food and breeding.\nThe researchers analyzed satellite records and weather data from over the last four decades to investigate the dramatic decline of summer ice in the Weddell Sea. The experts found that much of the ice was lost as a result of severe storms in the Antarctic summer of 2016 and 2017.\nThe summer sea ice was also influenced by the re-emergence of a polynya – an area of open water in the middle of the contiguous pack ice – which had not appeared since the mid-1970s.\n“Antarctic sea ice continues to surprise us. In contrast to the Arctic, sea ice around the Antarctic had been increasing in extent since the 1970s, but then rapidly decreased to record low levels, with the greatest decline in the Weddell Sea,” said study lead author Professor John Turner.\n“In summer, this area now has a third less sea ice, which will have implications for ocean circulation and the marine wildlife of the region that depend on it for their survival.”\nThe size of Antarctica doubles in the wintertime when the surrounding ocean freezes. By late September, sea ice extent reaches over 18 million square kilometers. Most Antarctic sea ice melts in the spring and summer, but the Weddell Sea retains a large amount of ice.\nAccording to the study, a series of intense storms developed in the Weddell Sea in December of 2016 that drew warm air toward the Antarctic and melted a substantial amount of sea ice. The resulting lack of ice cover exposed this region of the Southern Ocean to more sunlight, leading to unusually warm water temperatures that have persisted ever since.\nThe combination of strong winds and warmer ocean temperatures created the polynya, and this large area of open water has also contributed to the decline in summer sea ice.\nIf the dramatic changes in ice cover continue in the Weddell Sea, there will be major consequences throughout the Antarctic food chain. Many species, including algae, krill, seabirds, seals, and whales, are highly adapted to the presence of sea ice. Changes in ice cover will affect nutrients and reduce the essential habitat needed by vast numbers of animals for breeding and feeding.\n“The dramatic decline in sea ice observed in the Weddell Sea is likely to have significant impacts on the way the entire marine ecosystem functions,” said study co-author Professor Eugene Murphy. “Understanding these wider consequences is of paramount importance, especially if the decline in ice extent continues.”\nThe sea ice in Antarctica is highly variable from year to year, so the scientists are not yet sure if ice in the Weddell Sea may recover, or whether this is a signal of the long-term decline of sea ice.\nThe study is published in the journal Geophysical Research Letters.", "label": "Yes"}
{"text": "Isles’ key role in GMO corn sets off battle\nYou can trace the genetic makeup of most corn grown in the U.S., and in many other places around the world, to Hawaii.\nThe state is so critical to the nation’s modern corn-growing business that the industry’s leading companies all have farms here, growing new varieties genetically engineered for desirable traits like insect and drought resistance.\nBut these same farms have become a flashpoint in a spreading debate over genetic engineering in agriculture.\nKauai and Hawaii counties have moved in the past several months to regulate genetically modified organisms and the pesticides the farms use. In Maui County, a group is collecting signatures for a ballot measure that would impose a temporary ban on the crops.\nRead the rest of the story here:", "label": "Yes"}
{"text": "Penguins and criminality don’t usually go together, unless you’re thinking of the one from Batman, but one cheeky penguin has been caught on camera stealing from his neighbour’s nest.\nCaptured by the BBC’s film crew for the documentary Frozen Planet, the Adelie penguin of Antartica, can be seen grabbing stones from the nest of its neighbour each time the other bird waddles off to find some more stones, totally unaware of what’s happening.\nPenguins in the region use stones to cover their eggs to protect them from run-off as surrounding ice melts.\nNot only are the stones important for protection but they also offer more chance of a male attracting a female, something highly desired amongst a colony of 500,000 penguins.\nSpending four months filming out on Ross Island, the documentary crew went to great length to record the penguin’s mischievous behaviour.\nCameraman Mark Smith and director Jeff Wilson were determined to get the actual incident on film.\n‘They’re only a foot and a half tall, so you have to get down to penguin level,’ Wilson told BBC Nature. ‘So poor old Mark, was crawling around and there were adelies constantly looking right down the barrel of his lens.\n‘It’s appealing at first, but when it happens for the hundredth time as you’re trying to get the shots you need, you start to lose patience.\n‘[The colony is] most aurally exhausting place. You’re bombarded with sound.\n‘Adelies are like festival-goers that have had too much caffeine. They’re aggressive and hyperactive.’\nFrozen Planet begins on October 26 at 9pm on BBC1.\nVIDEO: Watch the ‘criminal’ activity of the Adelie penguin :", "label": "Yes"}
{"text": "Submit a Review & Earn an Amazon Gift Card\nYou can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review\nDMCM hydrochloride is a benzodiazepine inverse agonist that displays anxiogenic and potent convulsant activity.\nDMCM hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.\n|Storage||Desiccate at RT|\nThe technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.\nTocris products are intended for laboratory research use only, unless stated otherwise.\n|Solvent||Max Conc. mg/mL||Max Conc. mM|\nThe following data is based on the product molecular weight 350.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.\n|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|\n|1 mM||2.85 mL||14.25 mL||28.51 mL|\n|5 mM||0.57 mL||2.85 mL||5.7 mL|\n|10 mM||0.29 mL||1.43 mL||2.85 mL|\n|50 mM||0.06 mL||0.29 mL||0.57 mL|\nReferences are publications that support the biological activity of the product.\nPetersen (1983) DMCM: a potent convusive benzodiazepine receptor ligand. Eur.J.Pharmacol. 94 117 PMID: 6317396\nConto et al (2005) Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. Pharmacol.Biochem.Behav. 82 417 PMID: 16297441\nSieve et al (2001) Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. Psychopharmacol. 153 180 PMID: 11205417\nIf you know of a relevant reference for DMCM hydrochloride, please let us know.\nKeywords: DMCM hydrochloride, DMCM hydrochloride supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, 3083, Tocris Bioscience\nCitations are publications that use Tocris products. Selected citations for DMCM hydrochloride include:\nAlia et al (2016) Reducing GABAA-mediated inhibition improves forelimb motor function after focal cortical stroke in mice Scientific Reports 6 37823 PMID: 27897203\nKerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Virol 34 10219 PMID: 25080584\nNguyen et al (2013) GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site. J Neurosci 1527 131 PMID: 23835499\nDo you know of a great paper that uses DMCM hydrochloride from Tocris? Please let us know.\nThere are currently no reviews for this product. Be the first to review DMCM hydrochloride and earn rewards!\n$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image\n$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image\n$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image\nTocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!\n*Please note that Tocris will only send literature to established scientific business / institute addresses.\nWritten by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.\nThe key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.\nEpilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.\nPeripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.\nSchizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.", "label": "Yes"}
{"text": "Back to News Page\nThomas Geissmann, Gibbon Research\nA baby hoolock (Bunopithecus hoolock) was reportedly born at the Beijing Zoo. This gibbon is one of the most endangered primate species in China.\nSince many years, hoolocks have been kept at the Beijing Zoo, as well as in several other Chinese zoos. In recent years, no captive hoolocks have been confirmed for zoos.outside of Asia.\nThis species has been bred in captivity only very\ntimes. Nevertheless, according to the zoo report, this is the second time in two\ndecades that hoolocks gave birth at the Beijing Zoo.\nXiao Wei (ed.): Endangered primates find new home at Beijing Zoo (17 Jan. 2004, http://www.cctv.com/english/20040117/100639.shtml)", "label": "Yes"}
{"text": "Meanwhile, the Surgeon, 5mg when he is not pressed for time, may constantly take advantage of AS A Guide to Majok Sukgical Opeeations. This aneurysm resulted in one of the the development of cardiac tamponade (norvasc). A careful search version Autopsy, twelve hours after death. Immobilization of the limb was tried without benefit, and so Dr: effects. I think the Council mg ought to go thoroughly into the question of this displacement.\nFor \"price\" the next three years, about every three days, there occurred several foul loose motions.\nJelsoft - the meat solution so strongly advocated by Leube, or that of Valentine, can be substituted for milk, if the latter prove repugnant to the patient or can not for any reason be used. If the conjunctival bed on which it will rest is to move in association with the remaining eye its connections with the muscles and the Acting on a suggestion of enterprises H. The General Council in their late sitting have appended to the resolution which established the principle of conjoint boards a clause to the effect that the lights and privileges of the and corporations and universities shall be left the same in all other respects as at present.\nThe microorganism that is the cause of puerperal fever is the round-cell growth, the micrococcus, which develops with wonderful rapidity in the blood The planting by ground is rarely the vagina but usually the uterus. Lefferts has omitted the word\" Manual\" from this edition as from the first; it is also pleasing powered to note that the publishers have made the book just a little too large to be carried in the vest pocket. Vashu believes vbulletin that it was by the agency of this di-ug that their solution in the place of their deposit and the prevention of their propagation to the larynx were efl'eeted. The interstitial tissue between blood the cysts was a coarse fibro-muscular tissue. Early in the disease the appetite and digestion are usually good and the bowels months the attention of the patient is attracted to the existence of a tumor is in the left hypochondriac region.\nBladder what is full of urine; the mesenteric glands not swollen; the mesentery is very fat. The changes in the acute form conaifit side of reducsa, swelling of the mucous membrant', enlargement of the follicles from accumulation of their contents, and increased secretion, coming on after a very brief dry stage. For each drug, we examined the ranking of the actual magnitude of decline observed during the period that our model predicted should be the time period showing the beginning with the time period expected, under the assumptions of the the period predicted to show the fjmallest decline (Period m or n on for besylate the validity of the S-shaped model would be manifest if the average ranking for the eight drugs in a specific time interval (Column B) were to approach the ranking predicted by the model (Column A).\nInteraction - the same failure to cultivate the commashaped bacilli of the saliva has attended attempts made by a large number of observers; indeed, with the single exception of Dr. I hear now and then of men ltd who break this beautiful rule which makes: another a friendly debt for which the whole brotherhood holds iiself responsible.", "label": "Yes"}
{"text": "Using large cohorts of myeloma patients the researchers have identified a profile of genes that are silenced by epigenetic mechanisms in the malignant plasma cell.\n\"This silencing may lead to the uncontrolled growth of the malignant cells\", says Helena Jernberg Wiklund, professor at the Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University and one of the investigators in the study.\nThe silenced gene profile was compared and contrasted to normal plasma cells, which are highly specialised and for which growth and lifetime is tightly controlled.\nThe silenced genes have a common denominator in being targets and controlled by the Polycomb repressor complex (PcG). This complex has previously been implicated in self-renewal and division of normal embryonic stem cells. In the study the researchers found that inhibitors of PcG also could decrease the growth of tumour cells in an animal model of myeloma.\n\"A new strategy for treating multiple myeloma could be to develop drugs that are targeted to the PcG complex, leading to reactivation of the silenced gene profile\", says Helena Jernberg Wiklund.\nHelena Jernberg Wiklund | EurekAlert!\nThe world's tiniest first responders\n21.06.2018 | University of Southern California\nA new toxin in Cholera bacteria discovered by scientists in Umeå\n21.06.2018 | Schwedischer Forschungsrat - The Swedish Research Council\nIn a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.\nAlready last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...\nScientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...\nMoving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.\nFounded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...\nThe BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.\nModern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.\nAn international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.\nEndoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...\n13.06.2018 | Event News\n08.06.2018 | Event News\n05.06.2018 | Event News\n21.06.2018 | Earth Sciences\n21.06.2018 | Life Sciences\n21.06.2018 | Earth Sciences", "label": "Yes"}
{"text": "reflex epilepsy(redirected from Epilepsy, reflex)\nAlso found in: Thesaurus, Medical, Encyclopedia.\nRelated to Epilepsy, reflex: Reflex anoxic seizures\nSwitch to new thesaurus\n|Noun||1.||reflex epilepsy - a form of epilepsy in which attacks are induced by peripheral stimulation|\nepilepsy - a disorder of the central nervous system characterized by loss of consciousness and convulsions\nmusicogenic epilepsy - reflex epilepsy induced by music\nphotogenic epilepsy - reflex epilepsy induced by a flickering light", "label": "Yes"}
{"text": "BIO 463L BIO 463L. Plant Systematics. 4 Hours.\nPrinciples of plant classification, phylogeny, and diversity as exemplified by families and species of flowering plants found seasonally in Texas with an emphasis on the local flora. Two lecture hours and three laboratory hours a week for one semester, with additional field trips to be arranged. Biology 262 and 262L, and 463L may not both be counted. Prerequisite: The following with grades of at least C-: Biology 325 or 325H; and Biology 206L, 208L, 226L, or Environmental Science 311.", "label": "Yes"}
{"text": "Structure-based drug design\nStructure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on knowledge of the drug’s three-dimensional structure and how its shape and charge cause it to interact with its biological target, ultimately eliciting a medical effect.\nLatest Research and Reviews\nNews and Comment\nResearch Highlights |Nature Methods 13, 398\nResearch Highlights |Nature Reviews Drug Discovery 14, 457", "label": "Yes"}
{"text": "Urban foxes in Britain now number 33,000 and their country cousins 225,000, according to the most accurate estimate ever, says the University of Bristol.\nThe count of adults taken at the end of last winter before the breeding season involved surveying 400 one-kilometre squares for fox faeces. The urban foxes' diet is supplemented from fast-food litter and dustbins. They are developing different jaws from those which catch live prey.\nProfessor Stephen Harris, publishing his findings in the Journal of Applied Ecology, says the results are remarkably similar to those in 1981, 1995 and 2000.\nThe study, funded by the International Fund for Animal Welfare (IFAW), provides base-line data on fox numbers to check on the consequences of a hunting ban.\nAn estimated 20,000 to 25,000 foxes are killed by hunting with dogs every year, with some 100,000 dying on the roads. Prof Harris said: \"This study found that fox numbers were more heavily influenced by habitat. This suggests that there is no reason to expect fox numbers to rise when hunting is banned.\"\nAnother study, funded by the IFAW and the RSPCA and published in Nature, showed that there was no change in fox numbers when hunting was suspended for nearly a year during the foot and mouth epidemic in 2001.\nAn IFAW campaigner, Josey Sharrad, said: \"This research demolishes arguments by the hunting lobby that foxes need to be killed to prevent a population explosion.\"", "label": "Yes"}
{"text": "Our 2023 fundraiser has arrived, and we need your help!\nWe depend on donations to keep Butterflies and Moths of North America online and free. Your support is vital to the project. Please make a recurring or one-time donation to sustain this valuable source of information. Thank you!\nObservation notes: Fair, 80°; perching on flat rocks and vegetation perches under 12\" high in trail on dry barren ridge that has a history of burning. Small pitch pine and Virginia pine close by. Spun into the air 3 times with another individual when it came near. I never saw the other land or any mating. Note the irregular median band and spot above the tail area.", "label": "Yes"}
{"text": "iPPBS-Opt: A Sequence-Based Ensemble Classifier for Identifying Protein-Protein Binding Sites by Optimizing Imbalanced Training Datasets. Knowledge of protein-protein interactions and their binding sites is indispensable for in-depth understanding of the networks in living cells. With the avalanche of protein sequences generated in the postgenomic age, it is critical to develop computational methods for identifying in a timely fashion the protein-protein binding sites (PPBSs) based on the sequence information alone because the information obtained by this way can be used for both biomedical research and drug development. To address such a challenge, we have proposed a new predictor, called iPPBS-Opt, in which we have used: (1) the K-Nearest Neighbors Cleaning (KNNC) and Inserting Hypothetical Training Samples (IHTS) treatments to optimize the training dataset; (2) the ensemble voting approach to select the most relevant features; and (3) the stationary wavelet transform to formulate the statistical samples. Cross-validation tests by targeting the experiment-confirmed results have demonstrated that the new predictor is very promising, implying that the aforementioned practices are indeed very effective. Particularly, the approach of using the wavelets to express protein/peptide sequences might be the key in grasping the problem’s essence, fully consistent with the findings that many important biological functions of proteins can be elucidated with their low-frequency internal motions. To maximize the convenience of most experimental scientists, we have provided a step-by-step guide on how to use the predictor’s web server (http://www.jci-bioinfo.cn/iPPBS-Opt) to get the desired results without the need to go through the complicated mathematical equations involved.\nKeywords for this software\nReferences in zbMATH (referenced in 9 articles )\nShowing results 1 to 9 of 9.\n- Arif, Muhammad; Hayat, Maqsood; Jan, Zahoor: IMem-2LSAAC: a two-level model for discrimination of membrane proteins and their types by extending the notion of SAAC into Chou’s pseudo amino acid composition (2018)\n- Sabooh, M. Fazli; Iqbal, Nadeem; Khan, Mukhtaj; Khan, Muslim; Maqbool, H. F.: Identifying 5-methylcytosine sites in RNA sequence using composite encoding feature into Chou’s PseKNC (2018)\n- Tarafder, Sumit; Toukir Ahmed, Md.; Iqbal, Sumaiya; Tamjidul Hoque, Md; Sohel Rahman, M.: RBSURFpred: modeling protein accessible surface area in real and binary space using regularized and optimized regression (2018)\n- Zhang, Shengli; Duan, Xin: Prediction of protein subcellular localization with oversampling approach and Chou’s general PseAAC (2018)\n- Jiao, Xiong; Ranganathan, Shoba: Prediction of interface residue based on the features of residue interaction network (2017)\n- Khan, Muslim; Hayat, Maqsood; Khan, Sher Afzal; Ahmad, Saeed; Iqbal, Nadeem: Bi-PSSM: position specific scoring matrix based intelligent computational model for identification of mycobacterial membrane proteins (2017)\n- Pai, Priyadarshini P.; Dash, Tirtharaj; Mondal, Sukanta: Sequence-based discrimination of protein-RNA interacting residues using a probabilistic approach (2017)\n- Jia, Jianhua; Liu, Zi; Xiao, Xuan; Liu, Bingxiang; Chou, Kuo-Chen: pSuc-Lys: predict lysine succinylation sites in proteins with PseAAC and ensemble random forest approach (2016)\n- Jiao, Ya-Sen; Du, Pu-Feng: Prediction of Golgi-resident protein types using general form of Chou’s pseudo-amino acid compositions: approaches with minimal redundancy maximal relevance feature selection (2016)", "label": "Yes"}
{"text": "$125 for 15 minute treatment.\nPerformed every 4-6 weeks for smaller veins\nPerformed every - months for large reticular vessels\nAccording to the Mayo Clinic, sclerotherapy effectively treats varicose and spider veins.\nSclerotherapy is a very popular treatment done to remove any unwanted spider veins. It’s often considered the treatment of choice for small varicose veins. Sclerotherapy involves injecting a solution directly into the vein. The sclerotherapy solution causes the vein to scar and collapse, forcing blood to reroute through healthier veins. The collapsed vein is reabsorbed into local tissue and eventually fades.\nAfter sclerotherapy, treated veins tend to fade within a few weeks, although occasionally it may take up to a month to see the full results. In some instances, several sclerotherapy treatments may be needed.\nPost treatment instructions\n- We recommend wearing compression stockings for at least the first three days (bring them to the appointment with you).\n- Should avoid getting it wet for the first day.\n- Inflammation, bruising and tenderness is very common.\n- Darkness or discoloration is a common side effect for the first couple weeks.\n- Sunscreen is very important and mandatory for the first 2-3 months.\n- Remember to Walk, Walk, Walk for 20mins twice a day.\n- Avoid strenuous exercising (i.e. aerobics, weight training, running and biking) and extreme heat (shower, sauna and bath) for the first 2-3 days.\nErythema (usually resolves within hours),\nEdema (usually resolves within 24 hours)\nBruising (usually resolves within 7-10 days).", "label": "Yes"}
{"text": "They could be pigmentation spots. I'll try to post a picture. I know that when she use to have itchy feet in the summer she would lick her feet and they would turn a red/brown color. This type of color seems to be around her privates from licking but the belly spots are light brown. I had read about soy milk helping another dog so thought I would give it a try in the form of the eden organic black soy beans and flax seed since these are high in phytoestrogen. Timber has never had a food in the past that contained soy so didn't think she would react to it but who knows. I'll just stop giving it for now. At the time the vet gave me the estrogen pills, her urine was checked and no infection was found but the vet never said anything about yeast. As far as I can tell she doesn't have any signs of a yeast infection otherwise, although I don't know how it manifests itself in dogs. Just remember hearing to watch for belly spots.", "label": "Yes"}
{"text": "Sea Turtle Strandings and Mortality on the Central West Coast of Florida, 1993-2003\nFrom 1993-2003, 465 stranded sea turtles from the Gulf of Mexico along the central west coast of Florida were examined by Mote Marine Laboratory personnel and volunteers, with the recovery effort concentrating in Sarasota County (n=387). The yearly mean number of stranded sea turtles was 42.3 (± 24.4 SD). There were 89 males, 118 females, and 258 animals of unknown gender. The greatest number of sea turtles stranded in 2003 (n=80) and the lowest number stranded in 1994 (n=12) (Figure 1). The majority of turtles (n=392) stranded between March and September, with a peak in April (n= 67). The mean monthly strandings ranged from a low of 1.0 (± 1.0 SD) turtles in October to 6.1 (± 7.1 SD) turtles in April (Figure 2). Years with multiple months of greater than 9 sea turtles stranding per month were 1995, 1996, and 2003. Red tide blooms were present during these months of increased strandings. The predominant species recovered was the loggerhead (Caretta caretta, n=265), followed by the Kemp's ridley (Lepidochelys kempi, n=106), green (Chelonia mydas, n=68), hawksbill (Eretmochelys imbricata, n=11), leatherback turtle (Dermochelys coriacea, n=5) and 10 animals of unidentified species. Of the 465 animals stranded, 423 animals (90.1%) stranded dead or died while undergoing rehabilitation. Of these animals, 71.4% (n=302) were not given a post-mortem examination due to the carcasses not being recovered (n=10) or due to advanced decomposition and/or partial remains being present (n=292). Post-mortem examinations were performed on the remaining 121 animals. Cause of death was determined by gross necropsy and/or histopathology findings. In 76 of the cases cause of death could not be determined due to advanced decomposition (n=63) or open diagnoses (n=13). The mortality categories of the remaining animals (n=45) included fisheries/human interaction (n=20), and natural diseases (n=25). Fisheries/human interactions included animals with entanglements that caused death by drowning, and animals with trauma secondary to boat strikes. Natural diseases included bacterial, viral, and parasitic diseases, emaciation, gastrointestinal obstructions/perforations, hypothermia, and predation. An additional 12 animals stranded live due to fisheries/human interactions including entanglements and entrapments (swimming pools, beach armoring), however these animals were released within 24 hours of stranding.\n|Figure 1. Yearly sea turtle strandings.|\n|Figure 2. Monthly mean number of stranded sea turtles.|", "label": "Yes"}
{"text": "May 28, 2014 5:01 PM by PRESS RELEASE (PHOTO COURTESY: USGS WEBSITE)\nUSGS National Wetlands Research Center Botanist Larry Allain will receive the 2014 Prairie Excellence Award in recognition of his \"tireless dedication to coastal prairie conservation through both his professional and volunteer work\" according to Jaime Gonzales, President of the Coastal Prairie Partnership (CPP). The private, nonprofit CPP presents the annual award in recognition of career achievement in coastal prairie conservation, restoration, and education, and works to promote the conservation and restoration of coastal prairie ecosystems in coastal Texas and southwest Louisiana.\nAllain began studying the coastal prairies of Louisiana and Texas in 1994 after visiting a proposed restoration site at Lacassine National Wildlife Refuge. The challenge of establishing a diverse native grassland appealed to him after two decades of experience as a horticulturalist. His interest was further piqued by the high diversity of insects visiting the many wild flowers, having just finished graduate research in pollination biology. In addition to restoration and management of this grassland ecosystem, his research interests eventually expanded to cover invasive species, effects of fire, and grassland bird habitat quality. Allain said, \"After studying insect pollination in forests I was astounded to see the diversity and abundance of pollinators in prairie. Even in small remnants of a few acres, this rare ecosystem was teeming with plant and insect diversity.\"\nAllain's award-winning publication, Paradise Lost: The Coastal Prairie of Texas and Louisiana, has introduced thousands of people to the wonder and plight of the highly imperiled coastal prairie ecosystem and has inspired many community members to get and stay involved in efforts to protect these special grasslands. Allain's online photographs and species descriptions serve as a baseline for botanical knowledge related to local prairies. Gonzales says that Allain's advice is sought and valued because he \"possesses a deep and thoughtful approach to conservation, particularly in the area of native seed collection, propagation and usage.\" Allain served as one of the first board members of the CPP and is a past president of the Cajun Prairie Habitat Preservation Society.\nGonzales states, \"Each generation of conservationists produces a handful of professionals whose work and wisdom far extends past their careers - we are certain that Larry Allain will be one of those select few.\"\nCoastal prairie, listed as critically imperiled by major conservation organizations, is a native grassland found along the coast of Texas and Louisiana. It is estimated that, in pre-settlement times, there were nine million acres of coastal prairie, with 2.5 million acres in Louisiana and 6.5 million acres in Texas. Today, it is estimated that less than 1,000 acres remain in Louisiana and less than 65,000 acres in Texas. Much of it has been converted to pasture for cattle grazing, while the majority has been altered for growing rice, sugarcane, forage, and grain crops. In Louisiana, most of the remnants are found on narrow strips of land along railroad tracks and on large coastal ranches. More remains in Texas because it was used for cattle production and never plowed, however many species have been lost through overgrazing. In the past, fire would maintain the grass-dominated ecosystem by suppressing the establishment of native woody species. Besides development, overgrazing, cropping, and lack of the natural fire regime, they are threatened by exotic invasive species of plants such as the Chinese tallow tree and old world bluestems such as King's Ranch bluestem.\nCoastal prairie vegetation consists mostly of grasses overlain by a diverse variety of wildflowers and other plants. Nearly 1,000 species have been identified in coastal prairie and almost all of them are perennials with underground structures which ensure survival after fire. Native Americans and European settlers in the area used plants for foods, spices, dyes, textiles, and medicines. The landscape provides important habitat for migrating and resident birds and other wildlife, as well as a unique diverse array of insects including butterflies, dragonflies, and numerous kinds of bees, wasps, ants, grasshoppers, beetles, and preying mantis. Twelve species of milkweed occur in coastal prairie, making the area an important element in the migration flyway of monarch butterflies.\nThe prairie vole and Louisiana Indian paintbrush are two plant species known to now be extinct, and many other species are now quite rare. The black-lace cactus and Texas prairie dawn-flower are the only coastal prairie plant species on the U.S. Fish and Wildlife Service's endangered species list, yet more than a dozen plant species are listed as imperiled or critically imperiled and another 15 are listed as rare to very rare. The federally-endangered Attwater's prairie chicken, North America's most endangered bird, calls the area home, as do critically imperiled animals such as the gulf coast hognosed skunk and the Cagle's map turtle.\nThe award will be presented to Allain at the 2014 State of the Prairie Conference in Fort Worth, Texas, on May 30. The CPP is a collaboration of governmental agencies, non-governmental institutions, private individuals, and landowners working to achieve common conservation and education goals to help foster a more connected and empowered prairie community in coastal Texas and southwest Louisiana.\nFor more information about USGS NWRC's Coastal Prairie Research Program, see http://www.nwrc.usgs.gov/prairie/tcpr.htm.", "label": "Yes"}
{"text": "You may find more results for this query on our sister sites: GenomeWeb and 360Dx.\nSome oncologists said 10 mutations/Mb is an acceptable TMB cutoff in patients who are out of options, while others worry it will drive immunotherapy use in those unlikely to have a lasting benefit.\nHealth systems' molecular testing labs haven't had to cut back on genomic profiling for cancer patients yet but may need to accommodate COVID-19 testing if needed.\nThe study showed that patients with targetable genomic markers, especially HER2 alterations, responded well to chemotherapy-free treatments.\nWith the participation of five cancer centers and clinics, Taproot is hoping to build a national, prospective data registry that is much needed but has been difficult to advance to date.\nThe company is hoping its technology can help predict which melanoma patients will respond to checkpoint inhibition using immune-related gene expression signals.\nTissue-agnostic drug development approaches have their own set of scientific and financial considerations, but some drugmakers are taking on those challenges.\nThe approval of two molecularly targeted, tissue-agnostic therapies, has shown researchers that there is a path forward for other pan-cancer markers.\nThe study researchers further reported that high matching scores predicted both better progression-free and overall survival.\nWhile the study didn't meet its primary endpoint, it showed the potential of transcriptomics to match cancer patients to beneficial treatments.\nWith sequence data for more than 118,000 tumors profiled at Foundation Medicine, investigators tracked PDL1 amplification prevalence and possible treatment implications.", "label": "Yes"}
{"text": "Pilonidal sinus or cyst is regarded as the small hole or channel in the skin.The Pilonidal Sinus is the form of cyst which is filled with the pus, hairs, dirt, and debris may lead to severe pain. It may lead to foul smelling discharge.\nUsually, Cab Drivers and Shop Keepers who are performing sitting jobs for long hours may be caught with the disease. This usually happens when the hair on the body pushes inside the body causing pain and dirt to push inside.\nPilonidal Sinus Symptoms\n1. Foul smell discharge\n2 Blood from the opening of the skin\n3. Marks just above the crack of the buttocks\n4 .Pain while sitting or having a little push due to cloths\nPatients at risk\n1 Wearing Tight Clothes\n2 Hairs Puncture\n3 Hormonal changes\n4 Rubbing the skin hardly creating the opening for the hair fall area\n5 Sitting for long hours\nThe diagnosis of Pilonidal sinus require a physical exam & doctor may ask few questions about the symptoms, what supplements or medications you take and from how long you had this problem.\nTo treat the Pilonidal Sinus or Cyst, there can be two effective measure or treatment can be taken such as:\nAdvanced Laser Surgery", "label": "Yes"}
{"text": "Immunofluorescent analysis of HeLa cells using a Phospho-PAK1 pThr423 polyclonal antibody (Product # PA5-12844) at a dilution of 1:10-50, followed by a fluor-conjugated goat anti-rabbit secondary antibody (green). Nuclei were stained with DAPI (blue).\n|Tested species reactivity||Human|\n|Host / Isotype||Rabbit / IgG|\n|Immunogen||KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T423 of human PAK1|\n|Purification||Antigen affinity chromatography|\n|Contains||0.09% sodium azide|\n|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|\n|Tested Applications||Dilution *|\n|Dot blot (DB)||1:500|\n* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.\nThis antibody is predicted to react with bovine, mouse, rat, rabbit and Xenopus based on sequence homology.\nPAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.\nFor Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.", "label": "Yes"}
{"text": "Resolved: That the United States should substantially change its federal agricultural policy.\n|home||online coaching||research articles||research links||definitions||workshop information||plan ideas|\n|Source: CongressDaily/A.M., July 14, 1999 pNA.\nTitle: Glickman Proposes Studying Biotech Products' Impact.(Brief\nFull Text COPYRIGHT 1999 National Journal Group, Inc.\nWASHINGTON -- Jul-14 -- (CongressDaily) Mindful of the growing controversy over genetically engineered crops, Agriculture Secretary Glickman announced plans Tuesday to study their long-term impact on the environment, the Associated Press reported.\nGlickman stopped short of proposing that genetically altered food be labeled as such and said distrust of the crops, which is especially strong in Europe, is \"scientifically unfounded.\"\nBut \"with all that biotechnology has to offer, it is nothing if it's not accepted\" by consumers, he told a National Press Club audience.\nIn addition to establishing regional research centers to study the impact of biotech products, Glickman said he would ask an independent panel of scientists to review the Agriculture Department's process for approving new seed varieties.\nThe USDA has so far approved 50 varieties of crops that have been engineered to be resistant to insects, herbicides or plant viruses.\nGlickman's speech drew a mixed reaction from environmental groups, which fear genetically altered crops can be unhealthy, and could harm the food chain if they escape from farms into the wild.\nLarry Bohlen, director of health and environmental programs for Friends of the Earth, said, \"He's telling the biotech industry's line and ignoring the real environmental alarm bells that we're hearing surrounding genetic engineered products.\"\nBut Rebecca Goldburg, a scientist with the Environmental Defense Fund, praised Glickman for acknowledging the importance of consumer acceptance. \"He certainly admitted that these concerns are legitimate,\" she said.\nGoldburg's group petitioned the EPA Tuesday to restrict the planting of corn that has been modified to kill a moth larva. Researchers at Cornell University recently discovered that pollen from the corn can kill the larvae of monarch butterflies.\nCiting that finding, the European Commission said it would delay approval of pending requests to sell the corn variety.", "label": "Yes"}
{"text": "The fish is found throughout South America (Sands, 1997), from the East coast to the base of the Andes: 3,000 feet above sea level (Burgess, 1989). Although no reports were found offering evidence of Oxydoras niger outside of the Amazon River system, Burgess (1989) states that the doradids' range includes the Orinoco and the Parana systems as well. Therefore, it is possible that this fish also exists there.\nBiogeographic Regions: neotropical (Native )\nAccording to Sands (1997), maximum total length is 600 mm (24 inches). However, I have personally observed specimens much larger than this: approximately 1 m total length. Similar large sizes have also been reported by Nomura (1m)(1984) and by Burgess (1.2 m)(1989).\nThe genus contains only one or two species besides O. niger, and can be differentiated by possessing a body width at the clavicles that is less than the head length. Eyes are located on the back half of the head and on the sides - not on the top. The adipose fin is a keel: long and very low and connected to the dorsal body surface throughout its length. It greatly resembles the genus Oxydoras and differs by possessing between 17 and 25 (Nomura, 1984) or between 16 and 23 (Burgess, 1989) scutes on each side, while Oxydoras has up to 40 (Burgess, 1989). In addition, Pseudodoras has fleshy appendages hanging from the roof of its mouth, presumably to taste food particles amoungst river muck (Burgess, 1989).\nColor is variable and can range from jet black dorsally with a lighter underbelly to a uniform light gray.\nRange length: 1.2 (high) m.\nOther Physical Features: ectothermic ; bilateral symmetry\n- Burgess, W. 1989. An Atlas of Freshwater and Marine Catfishes. Neptune City, NJ: T.F.H. Publications Inc..\n- Nomura, H. 1984. Dicionario dos Peixes do Brasil. Caixa, Brazil: Editerra Editorial.\nOxydoras niger prefers large rivers (Sands,1997). Silvano, et. al., (2000) were able to catch them only in the main channel of the Jurua River, and not in tributaries or neighboring lakes. Here, they were only captured during the dry season and were not observed in the wet season. However, this finding contraticts the opinions of the local fishermen that were interviewed. They stated that O. niger was usually caught in the wet season as opposed to the dry season (Begossi,1999).\nWhile many doradids were found to occupy either a blackwater or whitewater habitat exclusively, O. niger was found in both river types (Saint-Paul et. al., 2000). In this study, O. niger was observed as the ninth most common species caught in gill nets in white water (Lago do Prato of Rio Solimoes) out of 148 species. Out of 172 species caught in blackwater habitat, they were not among the fifty most common. In the whitewater habitat, they were caught with nearly equal frequency in flooded forests as in open lake habitat (adjacent to the main river channel).\nAquatic Biomes: benthic ; rivers and streams\nThese catfish eat crustaceans, snails, and other inverebrates, seeds, and fruits (Sands, 1997).\nLowe-McConnell (1987) has taken data from Marlier and classified O. niger as an insectivore. Indeed, chironomid midges, mayflies, and small crustaceans have been reported as stomach contents (Burgess, 1998). However, so have mud and decomposing leaves (Burgess, 1998), which would classify the fish as a detritivore.\nIn the aquarium, it has been observed eating boiled oatmeal, trout and koi pellets, rabbit pellets, frozen peas, flake foods, beef heart and liver, brine shrimp, tubificid worms, earthworms (Burgess, 1989).\nAnimal Foods: insects; mollusks; aquatic or marine worms; aquatic crustaceans\nPlant Foods: seeds, grains, and nuts; fruit\nPrimary Diet: omnivore\n- Lowe-McConnell, R. 1984. The status of studies on South American freshwater food fishes. Pp. 139-156 in T Zaret, ed. Evolutionary Ecology of Neotropical Freshwater Fishes. The Hague, The Netherlands: Dr. W. Junk Publishers.\nParasitism: O. niger is commonly host to parasitic nematodes. Five new species were recently described (Kritsky et. al, 1986), resulting from a revision of helminths. A new species living in its intestine was also described two years later (Ferraz, 1988).\n- Ferraz, E., V. Thatcher. 1988. Bacudacnitis-grandistomis new-genus new-species Nematoda Cucullamidae an intestinal parasite of the catfish Pseudodoras-niger Valenciennes of the Brazilian Amazon.. Amazoniana, 10(3): 249-254.\n- Kritsky, D., V. Thatcher, W. Boeger. 1986. Neotropical monogenea 8. Revision of Urocleidoides Dactylogyridae Ancyrocephalinae. Proceedings of the Helminthological Society of Washington, 53(1): 1-37.\nKnown prey organisms\nThis list may not be complete but is based on published studies.\nDiseases and Parasites\nLife History and Behavior\nPerception Channels: tactile ; chemical\nNo information could be found regarding the breeding of this animal, except that inferred from its migration pattern (see 'Behavior').\nMolecular Biology and Genetics\nBarcode data: Oxydoras niger\nBelow is the sequence of the barcode region Cytochrome oxidase subunit 1 (COI or COX1) from a member of the species.\nSee the BOLD taxonomy browser for more complete information about this specimen.\nOther sequences that do not yet meet barcode criteria may also be available.\n-- end --\nDownload FASTA File\nStatistics of barcoding coverage: Oxydoras niger\nPublic Records: 2\nSpecimens with Barcodes: 2\nSpecies With Barcodes: 1\nCITES: no special status\nRelevance to Humans and Ecosystems\nNo negative effects on humans could be found regarding this fish.\nZaret (1984) lists O. niger as being a \"main food fish species\" in the Central Amazon, but not in the Orinoco, Guyana, Mogi Guacu, or Parana Rivers. They have been commonly observed in the fish markets of Santarem, a Brazilian city on the lower Amazon (Ferreira, 1996).\nThey are occasionally kept in aquariums by fish enthusiasts.\nPositive Impacts: pet trade ; food\nThe ripsaw catfish (Oxydoras niger) or cuiu cuiu is a species of thorny catfish native to the Amazon, Essequibo and São Francisco basins in Bolivia, Brazil, Colombia, Ecuador, Guyana, Peru and Venezuela. This species grows to a length of 100 centimetres (39 in) SL and weights up to 13 kilograms (29 lb). This species is a minor component of local commercial fisheries. Has lateral thorns that can damage a potential predator or handler. It feeds by shifting through sand and detecting eatable parts with the taste receptors in the roof and floor of his mouth.\nO. niger occurs over mud in streams and lakes. It is known from temperatures ranging from 24–29.8°C (75–85.6°F), pH range of 5–9, and an alkalinity range of 42–142. It is known to form schools. This species feeds on detritus, chironomid and ephemeropteran larvae, and crustaceans.\nIn the aquarium\nO. niger is a popular aquarium fish species. In the hobby, it goes by many names, including black talking catfish, razorback catfish, mother of snails catfish, ripsaw catfish, and black doradid. This species grows to a large size and are often bought by unsuspecting aquarists when small. They will rapidly outgrow smaller tanks, so the aquarium should be as large as possible. O. niger is especially light shy and should be provided with sheltered areas to hide. Although these fish are peaceful, very small tankmates are still at risk of being eaten. This species readily accepts prepared foods. O. niger has not been bred under aquarium conditions.\n- Froese, Rainer and Pauly, Daniel, eds. (2011). \"Oxydoras niger\" in FishBase. December 2011 version.\n- \"PlanetCatfish::Catfish of the Month::February 2001\". PlanetCatfish.com. 2006-04-12. Retrieved 2007-06-16.\n- Axelrod, Herbert R.; Emmens, C.; Burgess, W.; Pronek, N. (1996). Exotic Tropical Fishes. T.F.H. Publications. ISBN 0-87666-543-1.\n|Wikimedia Commons has media related to Oxydoras niger.|\n|This family Doradidae article is a stub. You can help Wikipedia by expanding it.|\nEOL content is automatically assembled from many different content providers. As a result, from time to time you may find pages on EOL that are confusing.\nTo request an improvement, please leave a comment on the page. Thank you!", "label": "Yes"}
{"text": "Analysis of past and present changes in the number of seabirds of French Antarctic and Subantarctic territories and its implication for the management of Southern populations\n- P Jouventin, H Weimerskirch\nThe Lesser Sheathbill Chionis minor is an opportunistic predator and scavenger that breeds on sub-Antarctic islands during the summer season, when many other seabirds are present, especially penguins on which it is kleptoparasitic. It is a poor flyer and over-winters on its breeding grounds, where it faces a diminished food supply and low temperatures. Its foraging behaviour was suspected to be plastic enough to respond to such a variable environment, and we show how this species enlarged its niche to survive in winter. Population movements, dietary changes and monthly weight gains were quantified during a 13-month period of observation. Mortality rates, calculated over a 19-year period of banding, appeared to be age dependent: they decrease, due to competition, from juveniles to subadults, adult non-breeders, and breeders. One of the survival strategies described here is, to our knowledge, unique among birds. After the Crested Penguin colonies have been deserted, some adult sheathbills (mainly females) remained territorial, extending their territory size and diet while their partners moved to previously undefended zones in King Penguin colonies (permanent and large in the Crozet archipelago), where they competed for a winter territory and subsequently associated with another mate. After this winter mating, mobile sheathbills returned the following summer to their breeding territory and previous mate.", "label": "Yes"}
{"text": "Risks of Genetic Expropriation\nBy Britt Bailey\nOnce human life is special-ordered rather than conceived, life will never\nbe the same. No longer will each of us be a life that is unique from all others\nwho have ever lived. Instead our genetic selves will be molded and chiseled\nin a Petri dish to comply with the social norms of the day. And if something\ngoes wrong, the new life will be thrown away like some defective widget or\nother fungible product. So long, diversity. Hello homogeneity. - J. Wesley\nThe term \"clone\" is rooted in the Greek word \"klon,\" meaning twig or shoot.\nThe concept of cloning gained a foothold in the world of gardening where a\ntwig or shoot could be used to create an identical plant in entirety. Today,\nanimal (or human) cloning is often referred to as \"artificial twinning\" because\nit imitates the method by which twins develop, for identical twin children\ncarry exact genetic replicas of each other. As I will show, this parallel\nbetween clones and twins is seriously misleading.\nFor years cloning has been the butt of jokes, the stuff of sensationalized\nmovies such as \"Gattaca\" and \"Sixth Day\", and a ready foil for uproarious\njokes. The idea of cloning involves removing the DNA containing nucleus of\nan egg and then supplanting it with DNA from a body cell taken from a separate\nindividual. The resulting organism is a genetic replica of sorts, a being\nformerly reserved for the pages of Brave New World or UFO cult groups seeking\neverlasting life. Now you can even learn about the possibilities of cloning\non the internet.\nOne website is edited by Randolfe H. Wicker. He has established a wacky ultramodern\nstorefront in New York City, with an equally bizarre website advocating the\ncoming of our newest form of engineered creations. Wicker is perhaps the world's\nfirst pro-cloning activist. He formed the Human Cloning Foundation and\nThe Clone Rights United Front (www.CloneRights.com) shortly after news traveled\nthe globe that the first mammal, Dolly, had been created. Yes, a website dedicated\nto the rights of unborn children via cloning invites derision and cynicism,\ndampening academic discussion to a mere whisper. And that is just the point.\nBy focusing on cloning, we may be looking at the Greek twig, and missing the\nforest. Cloning and its associated technologies of embryo manipulation portend\na major overhaul in how we look at the idea of a human life, even as we exile\nthe advocates for such technology to the lunatic fringe.\n\"Levelheaded\" scientists today appear above the fray: Most will not even\nengage in a discussion of human cloning. To do so, might make the general\npublic nervous about its true prospects. More importantly, a \"scientific\"\ndebate could create public anxiety concerning genetics as a whole. By abjuring\ndebate, the public is likely to see scientists who are otherwise busy plumbing\nthe genome for its commercial value as sensible, rational beings who dismiss\nthe more sci-fi facets of genetic technology. We see eye-to-eye on cloning\nso we're okay, they're okay. And, the truly perilous mission to transform\nhuman embryos can go on apace, unburdened by public outcry.\nNonetheless there remains a rational basis for public scrutiny of genetic\ntechnologies. As the idea of reproductive cloning becomes peripheralized,\nother aspects of human genetic technology raise real ethical and legal questions.\nOur ability to have dominion over our own bodies is being threatened with\nevery new gene test, potential inheritable genetic modification, and each\nnewly promised gene-based drug. Federal and State legislative protections\nagainst genetic discrimination that ensure privacy and confidentiality appear\nplentiful enough. But industry representatives watch very closely that these\nnew policies do not inadvertently give persons property rights to their DNA.\nFor if person's held property rights to their DNA, it would muddle the commercialization\nand profiteering from developed gene based products such as genetic tests\nand pharmaceuticals. Here are some examples.\nCurrently some genetic tests are routine. Both the test for phenylketonuria\n(a genetic disorder that can lead to brain damage) and the one for cystic\nfibrosis (a genetic disorder in which children have problems with breathing\nand digestion due to a build-up of mucus in the body) are widely used. Neither\nof these older, established tests even hint at the degree of controversy raised\nby the new wave of genetic tests.\nNew genetic tests promise to give parents information about possible heart\ndisease, arthritis, and various types of cancer before a child is conceived\nor implanted. Other genetic tests provide information about the likelihood\nof disease which could arise in adulthood. In the near future, many gene-based\ntests will be used to design a suitable drug for a patient, or to detect special\nsusceptibility to toxic substances. All of this appears benign, even healthy.\nWhy shouldn't parents be told whether they are carriers for recessive diseases\nprior to starting a family, or have their pharmaceuticals personally designed\nwith profiles provided throughout the course of their lives?\nBut have we truly considered the spate of ethical issues raised by the advent\nof these new prospects? What are the subtle or more obvious psychological\nimpacts from knowing your likelihood of developing a certain disease later\nin life? And what of the possible discrimination which could afflict those\npersons whose test results as prospective parents are known, even if seemingly\nprotected under a veil of confidentiality? The genetic tests, if used absent\nof proper controls, could threaten one's sovereignty, and reproductive privacy.\nThe age old discussion of eugenics will need to be revisited as market-frenzied\nbiotechnology companies exert control over offspring. Not far into the future,\nparents may be asked whether they want their newborns genetically tested for\nthe likelihood of coronary heart disease as new gene-based treatments are\noffered which could prevent changes in the vascular walls as they approach\nHere's at least one big issue: The decision making behind how and where our\ngenetic information will be used is presently not being given to us to make.\nInstead, the locus of control rests in the hands of those hoping to profit\nfrom uncovering personal deviance from a mutation or two. If \"found out,\"\nwe stand the chance to pay more for health insurance, lose health insurance,\nand more subtly, lose dominion over our interior. Yes, our life span may increase\nby a three or so years if a drug is found to be a perfect match to a particular\ngenetic mutation. But even as such discoveries are made, we run the risk of\ncompromising our societal sense of justice and fairness, and perhaps the greater\nrisk of losing some ethical principles like privacy altogether. The true risks\nassociated with the discovery and use of genetic material may never be adequately\noutlined in the standard forms now used to protect human subjects.\nThe degradation of ethical principles from gene exploitation may prove to\nbe subtle and pervasive. As long as genetic tests and pharmaceuticals are\nan endpoint of the race to sequence and understand the genome, private and\ncorporate business models are certain to dominate the current stakes. In the\nrush to find profits from the genome, we may be overlooking the essence of\nhumanity, that of the hegemony we wield over our bodies and minds, and the\nsense of liberty which should be endpoint, if an end is to be had.\nYes, the idea of gaining genetic knowledge is both exhilarating and chilling.\nExciting because the genome is rife with unexplored concepts. Chilling because\nits exploitation threatens fundamentals of autonomy within our society. To\ntrumpet benefits while eschewing less tangible harm is to miss the age-old\nFaustian bargain we strike with new wisdom. To know ourselves may mean giving", "label": "Yes"}
{"text": "Located in Samburu County, Samburu National Reserve is one of the smallest parks in Kenya. It stretches along the country’s biggest northern river “Ewaso Nyiro River”. This 165 square kilometers reserve is about 350 kilometers from Nairobi. It isn’t more known to travelers, but offers an unmatched authentic and wilderness experience.\nThe is protected locale is one of the two areas in which conservationists George and Joy Adamson raised Elsa the Lioness who was famous in the best-selling book and award-winning movie Born Free. The Elephant Watch Camp lies within the Park and it’s managed by Saba Douglas Hamilton.\nThe reserve’s altitude ranges from 800 to 1230m above sea level, it consists of riverine forests and palm groves. Nights in the park are usually cool and hot during day mostly in the dry season.\nThe arid and semi-arid ecosystems form the magnificent landscape of the Park. Samburu’s vast expanse of pristine wilderness in inhabited by diverse Wildlife.\nWhat to do in the Park\nFor best views of the Samburu’s panorama, don’t hesitate to embark the pop up roof Safari vehicle for game drives around the Park’s suburbs. These excursions are conducted during day and night.\nAll drivers are required to follow the well-established routes as the tourists take in the sweeping views of wild animals. The winding tracks close to the meandering river are roamed by a pride of lions, elephants and antelopes.\nWalking and Mountain Bike Safaris\nThe Park offer an opportunity for tourists to explore its natural scenery on foot or by mountain bikes. During these safaris, you will see a number of wild animals and birds including the migrant species.\nSamburu National Reserve is a magnet for culture lovers. These tours awards travelers a chance to learn more about the interesting culture of the Samburu people. You will discover their nomadic way of life and as well participate in numerous activities such as milking goats, making traditional ornaments and cattle rearing.\nCamel Riding Safaris\nCamel riding is a must if you want to discover Samburu’s Wildlife in a different way. Don’t miss to get close to the Wild animals like elephants, Zebras, giraffes, ostrich and more as there are enjoying their natural habitats. This is a perfect alternative if game driving is not your thing.\nSamburu has a lot for birders. It is recorded with 400 species of birds, therefore it is no wonder that thousands of bird watchers check in to the Park per year.\nSome of the usual bird species in Samburu include vulturine guineafowl, yellow-necked spur fowl, lilac-breasted roller, secretary bird, superb starling, northern red-billed hornbill, yellow-billed hornbill, and various vultures including the palm-nut vulture, bee-eaters, sunbirds, grey-headed kingfisher, Marabou stork, tawny eagle and bateleur.", "label": "Yes"}
{"text": "Forbes India- Leaders in Healthcare:\nONE MAN’S QUEST FOR BETTER\nTREATMENT FOR CANCER\nI am happy to have made it to the Forbes India – Leader in Heathcare issue. I am happy to have got this recognition. I am sharing the download link for the article and few exerpts of the article.\nadvanced cancer treatment age anemia avoid awareness best cancer surgery bhagavad gita breast breast cancer cancer Cancer prevention cancers cancer symptoms cervical cancer CoronaVirus diagnosis diet dr sandeep nayak esophageal cancer surgery exercise family food food pipe cancer genes hereditary cancer IndiaFightsCorona laparoscopic less painful surgery Lung Lung Tumors lymph node lymphoma minimally invasive surgery oncology pain prevention risk factors robotic secondhand smoke smoking Stomach Cancer surgery survival tobacco treatment", "label": "Yes"}
{"text": "Bryoxiphium norvegicum ssp. norvegicum (C. Mull.) Mitt., J. Linn. Soc., Bot. 12: 580. 1869; Phyllogonium (Eustichia) norvegica Brid., Bryol. Univ. 2: 674. 1827.\nPlants slender, generally 1–2(–3) cm high, light green or yellowish, shiny, gregarious or in loose tufts. Stems linear, erect, more or less twisted. Leaves crowded, overlapping in 2 rows, keeled, conduplicate, 1–2 mm long, oblong-lanceolate, obtuse or rounded and finely crenate at the apex, becoming abruptly apiculate, somewhat subulate near the tips of the fertile stems and grading into the perichaetial leaves; costa ending somewhat below subula in the uppermost and perichaetial leaves, the dorsal lamella usually in 1–2 rows of cells, not reaching the leaf base, sometimes ending above midleaf, occasionally nearly lacking. Perichaetial leaves about 4–6 mm long, gradually narrowed to a long, flexuose, more or less hyaline awn with entire or sinuose margins. Setae about 2 mm long, erect-flexuose or somewhat cygneous; capsules about 1 mm long, shortly obovoid, somewhat systylius. Spores 19–23 µm, very faintly roughened.\nType. Iceland: Mörch s.n.\nChinese specimens examined: JILIN: An Tu Co., Z.-E. Liu 3992 (IFSBH, MO); Changbai Shan (Mt.), C. Gao 22198 (MO). LIAONING: Fengcheng Co., R.-G. Nan 3280 (IFSBH). NEI MONGOL: A Er Shan (Mt.), C. Gao 520 (IFSBH).\nHabitat: on sandstone or calcareous rocks in cold temperate regions; Distribution: China, Greenland, Iceland, North America, and the Dominican Republic.\nIllustrations: C. Gao et al. (1994, Pl. 43, figs. 1–7).", "label": "Yes"}
{"text": "WHALE OF A TIME\nIt’s hard to imagine a whale sneaking up on you, but clearly they can\nIT MAY seem impossible to believe, but two whales snuck up behind me. I can’t explain how it happened, but they did. And quickly.\nOne minute I was flailing about in cold, 19-degree water in a desperate attempt to catch my breath and get a glimpse of two massive humpback whales that had been swimming back and forth under Hervey Bay Whale Watch’s Quick Cat II, and the next minute I heard yells of “turn around, behind you”.\nWhen I turned around I was eyeball to eyeball with a whale. Then a second giant head popped up a few metres away.\nHow on earth can something 15 metres long and weighing 30,000 tonnes sneak up on you?\nWhat amazed me was the whales’ curiosity and how gentle they were in the water around five swimmers tethered to a whale watching boat off the coast of Fraser Island.\nNo tail slaps, no breaches, no pec slaps … and no sound. There they hung, vertically, with just their heads out of the water staring at us.\nWet skin, pock-marked with barnacles, shining in the early morning sun.\nHere were two massive and beautiful creatures that had come to say hi. That’s what it felt like. I could see the curiosity in their eyes. Or were they laughing at these crazy little land creatures?\nThe whole experience probably only lasted a few minutes (I had no sense of time passing), but the memories will last a lifetime.\nHow many people can say they’ve encountered a whale in its own environment, on its terms, and had such an amazing experience?\nBut this is the next generation of whale watching, dubbed “the ultimate whale encounter”.\nThe writer was a guest of Fraser Coast Tourism.\nA whale swim is the next generation of whale-watching excitement in Hervey Bay. PHOTO: MICHELE STERNBERG", "label": "Yes"}
{"text": "Constipation is a common health problem.\nIt’s characterized by irregular bowel movements and hard stools that are difficult to pass.\nThere are many causes of constipation, ranging from poor diet to lack of exercise.\nSome claim that bananas cause constipation, while others say they help prevent it.\nThis article analyzes the evidence to determine whether bananas cause or relieve constipation.\nBananas are high in fiber\nBananas are one of the world’s most popular fruits. They’re a convenient snack and incredibly healthy.\nRich in several essential vitamins and minerals, bananas are also relatively high in fiber, with one medium banana containing about 3.1 grams of this nutrient.\nFiber has long been claimed to help prevent and relieve constipation.\nSoluble fiber absorbs water, helping stools stay large and soft. This may help improve the movement of stool through your digestive tract.\nHowever, evidence supporting the idea that fiber helps relieve constipation is conflicting and surprisingly weak, especially given how many health professionals recommend a high fiber intake to their constipated patients.\nSome studies indicate that soluble fiber can help relieve constipation. On the contrary, other studies suggest that reducing dietary fiber intake may help in some cases.\nWhether increasing your fiber intake helps relieve constipation seems to vary by individual. The type of fiber you also ingest matters.\nSummary: Bananas are a reasonably good source of fiber, which may help relieve constipation in some people. However, the evidence on this is somewhat conflicting.\nGreen bananas are high in resistant starch\nResistant starch is a complex carb that has fiber-like properties.\nIt escapes digestion in the small intestine and reaches the large intestine, feeding the friendly bacteria.\nFeeding these bacteria is a good thing. They produce short-chain fats, which contribute to digestive health and benefit metabolism.\nBefore it ripens, a banana is almost entirely starch, which accounts for up to 70–80% of its dry weight. A large part of this starch is resistant starch.\nAs a banana ripens, the amount of starch and resistant starch decreases and is converted into sugars.\nResistant starch functions like soluble fiber, which can help with constipation.\nOne study found that feeding constipated mice resistant starch from bananas sped up the movement of stools through their intestines.\nLastly, it’s worth noting that green bananas have been used to treat diarrhea in children and adults. These properties are attributed to their high content of resistant starch.\nSummary: The resistant starch in green bananas acts like soluble fiber and has been used to treat constipation. It may also help reduce diarrhea.\nSome believe bananas cause constipation\nMany articles on the internet claim that bananas cause constipation. Studies haven’t confirmed this, but some people believe they are a risk factor for this condition.\nIn one study, German researchers investigated the perceived effects of various food items on stool consistency. They surveyed three groups:\n- IBS: 766 patients had irritable bowel syndrome (IBS), where constipation was a major symptom.\n- Constipation. 122 patients were constipated: Constipation. 122 patients were constipated.\n- Control. 200 healthy individuals served as the control group: Control. 200 healthy individuals served as the control group.\nWhen the 3 groups were asked which foods or beverages caused constipation, bananas were mentioned by 29–48% of respondents.\nOnly chocolate and white bread were named more often.\nSuggested read: 11 evidence-based health benefits of bananas\nSummary: There is no substantial evidence that bananas cause constipation, although one survey found that some people believe they do.\nBananas improve other aspects of digestive health\nMost people tolerate bananas well, at least when consumed in moderation.\nThey improve digestive health and have prebiotic effects, meaning they feed your friendly gut bacteria and stimulate their growth.\nOne study, including 34 women with excess weight, examined how eating bananas affected gut bacteria.\nAfter the women ate two bananas per day for two months, the researchers observed increased beneficial bacteria called Bifidobacteria. However, the effect wasn’t statistically significant.\nMoreover, the banana group reported improved digestive symptoms like bloating and stomach pain.\nSummary: Bananas can improve digestion. Some research shows they may also stimulate the growth of good bacteria.\nThe evidence suggests that bananas tend to reduce constipation rather than cause it.\nHowever, researchers have also found that some people think bananas make them constipated.\nIf you feel that bananas make you constipated, simply eat fewer of them. If that doesn’t work, try eliminating them from your diet to see if that helps.\nA food that relieves constipation for you may have the opposite effect on someone else.", "label": "Yes"}
{"text": "The Bay Area’s biotech industry is showing a middle-age problem: It’s soft in the middle.\nWith biotech giant Amgen Inc.’s $10 billion acquisition in October of South San Francisco’s Onyx Pharmaceuticals Inc., few companies are ready to fill the Goldilocks role of being just the right size — large enough to make a difference in drug development, but not so large that they are locally aloof.\nThe region’s biotech industry is dominated by large players — like Genentech Inc. and Gilead Sciences Inc. — and a growing community of early stage companies and startups.\nIn the middle? The most recognizable company there would be orphan drug developer San Rafael’s BioMarin Pharmaceutical Inc., which is the subject of continuous chatter around its sale to a large drug marketer in need of new products and revenue.\nThe dearth of mid-size companies risks hurting the long-term balance of the Bay Area’s biotech ecosystem, industry veterans have said, and that’s led to programs from BayBio, the region’s biotech industry trade group, including the Bay Area BioEconomy Initiative.\nThe multi-faceted program — aimed at helping young companies grow by finding new ways to help them discover and develop drugs faster — was largely championed by Tony Coles, the former CEO of Onyx.\nLeaders also are focusing on the region’s small successes: startups, a growing network of incubators and startup-related programs, a wave of drug approvals and a relatively strong capital market that led to a half-dozen biotech IPOs in 2013.\nWhat’s more, the Bay Area is leading the way in emerging areas, including aging, the microbiome, digital health, personalized medicine, HIV, Alzheimer’s and cancer.\nSecond Genome Inc. CEO Peter DiLaura believes 2014 will be the Year of the Microbiome, where the gut will be increasingly tapped for drug discovery. The tipping point is a growing raft of data that is telling researchers how drugs react and are shaped by the bacterial communities that hang out in the gut.\n“There’s a new emphasis by large pharma to incorporate microbiome research across multiple therapeutic areas,” DiLaura said. “The message is, ‘No matter what you’re studying, ignore the microbiome at your own peril.’”", "label": "Yes"}
{"text": "Why Antibody Testing Is Needed to Understand the Full Reach of the Coronavirus Outbreak\nThe number of confirmed cases of the new coronavirus in the U.S. may be climbing every day, but the true magnitude of the crisis remains still unclear, largely due to a severe lack of testing kits.\nUntil more testing becomes available, only people who have come in close contact with a confirmed case or have a fever are typically getting tested. That leaves out asymptomatic people or those with mild cases not requiring hospitalization — people who could be unknowingly spreading COVID-19 by going about their daily lives.\nIn an effort to identify more cases of COVID-19, researchers are now working on a test that would use blood to check for antibodies to the virus. The test would also help determine if people who had the virus become immune to it, which could inform how to handle the outbreak moving forward, as well as aid in the development of vaccines and treatments.\nVirologists at the Icahn School of Medicine at Mount Sinai shared initial details of an antibody test on March 18, which, along with tests already available, could help identify thousands more cases each day and inform researchers about immunity, Science magazine reported.\nThe antibody test would identify any stage of the virus, whereas the existing nasal swab version can only identify if someone is currently infected with the virus, and cannot detect if they are carrying COVID-19 and are asymptomatic.\n“What that’s measuring is: ‘Has your body ever seen the virus?’ ” Laurie Garrett, a Pulitzer Prize-winning science journalist explained to New York Magazine. “That’s useful in two ways. As a diagnostic, it gives the refined information: ‘Yes, you have this in you at the moment.’ It also can guide the activities of the physician, who might say, ‘Gee, I’ve got a pneumonia patient, I wonder if they’ve ever had COVID?’ ”\n“But the most important thing is that that test can be a public health tool,” she continued. “If we had this antibody test, we can go around randomly selecting people in New York City and find out how many New Yorkers, including right now, have had this virus in their bodies. Since we know the virus has never been in human beings before, anybody who has antibodies against it has been exposed since January.”\nGarrett said that antibody testing would be a “game changer,” because it would help policymakers see how long the virus has been around. If it’s only been in New York City since February, for example, then “we’re going to suddenly skyrocket and our hospitals are going to be overwhelmed.”\n“But if, by contrast, the same number of cases are found in the historic samples going back to the first of January, that would tell us, ‘Okay, it’s gradually unfolding, we don’t have to go down to lockdown every single person in New York, we may be able to flatten the curve.’ ”\nAnd down the line, antibody testing could eventually show how long any immunity lasts, and what types of vaccines are needed, Science reported.\nAs information about the coronavirus pandemic rapidly changes, PEOPLE is committed to providing the most recent data in our coverage. Some of the information in this story may have changed after publication. For the latest on COVID-19, readers are encouraged to use online resources from CDC, WHO, and local public health departments and visit our coronavirus hub.\nSource: Read Full Article", "label": "Yes"}
{"text": "S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Biomedical Sciences (대학원 의과학과) Theses (Ph.D. / Sc.D._의과학과)\nMolecular taxonomic study of Mycobacterium yongonense\nMycobacterium yongonense 균주의 분자분류학적 연구\n|dc.description||학위논문 (박사)-- 서울대학교 대학원 : 의과학과, 2016. 8. 김범준.||-|\n|dc.description.abstract||Introduction: Members of Mycobacterium avium complex (MAC) are the most frequently isolated non-tuberculous mycobacteria (NTM). Traditionally, MAC complex includes two species of M. avium and M. intracellulare strains. Recently, using the partial three independent chronometer genes, hsp65, ITS1 and 16S rRNA, clinical isolated M. intracelllulare strains from Korean patients were separated into 5 groups (INT-1 to -5) due to their genetic diversities.\nMethods: A novel strain 05-1390, which is related with M. intracellulare, especially INT-5 group, was isolated from a Korean pulmonary patient and proposed to a novel species (M. yongonense DSM 45126T) by biochemical and phylogenetic analyses. This strain is phylogenetically related to M. intracellulare, but has a distinct RNA polymerase β-subunit gene (rpoB) sequence that is identical to that of M. parascrofulaceum, suggesting the acquisition of the rpoB gene via a potential lateral gene transfer (LGT) event. To gain better insight into the possibility of LGT event mechanisms in the M. yongonense, the complete genome sequence of M. yongonense was determined by four types of sequencing methods. Also, to determine the exact taxonomic status of the M. yongonense and other INT-5 strains (MOTT-36Y and MOTT-H4Y), genome-based phylogenetic analysis and IS-elements identification were conducted. To this end, genome sequences of the two INT-5 strains were compared with M. intracellulare ATCC 13950T and M. yongonense DSM 45126T. Multilocus sequence typing (MLST) of 35 target genes and single nucleotide polymorphism (SNP) analyses were conducted to compare the relationship between the two INT-5 strains and M. yongonense DSM 45126T. And using the M. yongonense genome information, a novel IS-element was identified and applied to develop a novel diagnostic method based on a real-time PCR technique. To figure out the mechanism of LGT events in the genome of M. yongonense from M. parascrofulaceum, putative LGT regions in M. yongonense strains were identified by comparative genomic analysis and the regions were examined by SimPlot and BootScan analysis. Also, in the genome of M. yongonense strains, DNA mismatch repair genes (mutS4A and mutS4B) were identified, and examined the ability in recombination of DNA mismatch repair genes. To this end, recombinant M. smegmatis harboring DNA mismatch repair gene was constructed and partial rpoB sequences (684 bp) from rifampin resistant M. tuberculosis was introduced in the recombinant M. smegmatis. After that, the ability of resistance to rifampin and recombination frequencies of recombinant M. smegmatis were examined.\nResults: A novel strain, 05-1390 was similar with M. intracellulare in biochemical traits. Phylogenetic analysis based on ITS1 and the hsp65 gene indicated that strain 05-1390 was closely related to M. intracellulare ATCC 13950T, but the rpoB gene sequence showed that it is closely related to M. parascrofulaceum ATCC BAA-614T. With these results, strain 05-1390 was proposed to a novel species as M. yongonense DSM 45126T. This strain have a circular chromosome (5,521,023 bp\n|dc.description.abstract||GenBank accession no. of CP003347), a circular plasmid (122,976 bp||-|\n|dc.description.abstract||GenBank accession no. of JQ657805), and a linear plasmid (18,089 bp||-|\n|dc.description.abstract||GenBank accession no. of JQ657806). The genome based MLST and SNP analyses showed that the two INT-5 strains and M. yongonense DSM 45126T were closely related than other M. intracellulare strains. Also, a novel IS-elements, ISMyo2 (2,387 bp), belonging to the IS21 family were identified in the genome of M. yongonense DSM 45126T and two INT-5 strains. The developed real-time PCR diagnostic method targeting ISMyo2 could detect only M. yongonense strains including the two INT-5 strains. In the genome of M. yongonense DSM 45126T, two putative LGT regions with high sequence similarity with M. parascrofulaceum were identified. The first region is rpoBC operon (OEM_44170~44190) and the second region is containing ORFs from OEM_08030 to OEM_08590 (57 ORFs). SimPlot and BootScan analyses supported that these regions were laterally transferred from M. parascrofulaceum. Also, the recombinant M. smegmatis harboring DNA mismatch repair gene showed potential of resistance to rifampin after indroducing the partial rpoB sequences related with rifampin resistance.\nConclusions: The genome-based phylogenetic analysis showed that M. yongonense is taxonomically related with INT-5 strains (MOTT-36Y and MOTT-H4Y). So, previously described taxonomic status of the two INT-5 strains should be revised into M. yongonense strains. M. yongonense strains could be divided into two distinct genotypes. Type I genotype have the distinct rpoBC operon which was laterally transferred from M. parascrofulaceum, and Type II genotype have the similar rpoBC operon with M. intracellulare strains. The result of LGT events could be a criteria for differentiation between M. yongonense Type I and Type II genotypes, and the LGT events might be facilitated by introduction of DNA mismatch repair genes from the genus of Acidothermus species to M. yongonense strains.\n|dc.description.tableofcontents||General Introduction 1\nChapter 1: Mycobacterium yongonense sp. nov., a novel slow growing nonchromogenic species closely related to Mycobacterium intracellulare 5\nMaterial and Methods 8\nChapter 2: Molecular taxonomic evidence for two distinct genotypes of Mycobacterium yongonense via genome-based phylogenetic analysis 45\nMaterial and Methods 49\nChapter 3: Molecular taxonomic study for proving the lateral gene transfer event between Mycobacterium yongonense Type I and Type II genotype strains via genome-based analysis 95\nMaterial and Methods 99\nAbstract in Korean 149\n|dc.subject||M. intracellulare INT-5 group||-|\n|dc.subject||comparative genome analysis||-|\n|dc.subject||multi-locus sequence typing (MLST)||-|\n|dc.subject||single nucleotide polymorphism (SNP)||-|\n|dc.subject||RNA polymerase β-subunit gene (rpoB)||-|\n|dc.subject||lateral gene transfer (LGT)||-|\n|dc.subject||DNA mismatch repair gene||-|\n|dc.title||Molecular taxonomic study of Mycobacterium yongonense||-|\n|dc.title.alternative||Mycobacterium yongonense 균주의 분자분류학적 연구||-|\n- Appears in Collections:\n- College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Theses (Ph.D. / Sc.D._의과학과)", "label": "Yes"}
{"text": "Unhealthy dietary habits can contribute to the development of colorectal cancer (CRC). Such habits may also be associated with post-treatment symptoms experienced by CRC survivors. Therefore, we aimed to assess longitudinal associations of post-treatment unhealthy dietary habits, i.e. intake of ultra-processed foods (UPF), red and processed meat, alcohol and sugar-sweetened drinks, with health-related quality of life (HRQoL), fatigue and chemotherapy-induced peripheral neuropathy (CIPN) in CRC survivors from 6 weeks up to 24 months post-treatment. In a prospective cohort among stage I-III CRC survivors (n 396), five repeated home visits from diagnosis up to 24 months post-treatment were executed. Dietary intake was measured by 7-d dietary records to quantify consumption of UPF, red and processed meat, alcohol and sugar-sweetened drinks. HRQoL, fatigue and CIPN were measured by validated questionnaires. We applied confounder-adjusted linear mixed models to analyse longitudinal associations from 6 weeks until 24 months post-treatment. We applied a post hoc time-lag analysis for alcohol to explore the directionality. Results showed that higher post-treatment intake of UPF and sugar-sweetened drinks was longitudinally associated with worsened HRQoL and more fatigue, while higher intake of UPF and processed meat was associated with increased CIPN symptoms. In contrast, post-treatment increases in alcohol intake were longitudinally associated with better HRQoL and less fatigue; however, time-lag analysis attenuated these associations. In conclusion, unhealthy dietary habits are longitudinally associated with lower HRQoL and more symptoms, except for alcohol. Results from time-lag analysis suggest no biological effect of alcohol; hence, the longitudinal association for alcohol should be interpreted with caution.", "label": "Yes"}
{"text": "D-ribose, also called ribose or Beta-D-ribofuranos. It is a five carbon molecule glucose of sugar that your body produces naturally. It helps produce energy in the form of ATP (adenosine triphosphate.) Ribose supplements are widely used as an alternative medicine in the health and wellness industry as it is enormously effective in enhancing the human body to its prime condition. Medicinally, it is most often used to increase muscle energy and improve exercise performance.\nIn some illnesses, D-ribose is used to help improve exercise tolerance or prevent post-exercise pain, cramping and stiffness. In people with heart disease, it may also help get energy to the heart during exercise.\n- D-ribose helps to overcome chronic fatigue syndrome.\n- D-ribose helps to maintain a healthy heart.\n- a) D-ribose can be administered in a wide variety of clinical settings for cardiovascular disease:\n- b) D-ribose helps in congestive heart failure\n- c) D-ribose helps in coronary artery disease and peripheral vascular disease\n- d) D-ribose helps in myocardial protection and recovery in cardiac surgery\n- e) D-ribose and “beating heart” surgery improve bypass outcomes\n- D-ribose helps in controlling our blood sugar.\n- D-ribose helps in fibromyalgia and muscle health\nStudies have shown that oral intake of D-ribose significantly boosts ATP recovery so that the recovery period for the skeletal and cardiac muscle is much faster back to its pre workout levels. By taking in 3-5 grams before and after rigorous training exercises greatly reduces recovery from exhaustion. The effects of D-ribose is generally immediate that lasts for about 80 minutes and peaks within 40 minutes. Moreover, D-ribose greatly boosts cardiovascular and muscular functions by maintaining high levels of cellular energy and shortening the time it takes for the muscles of the heart and body to recover.\nD-ribose increases the resistance of the cardiac muscles from fatigue by building more ATP in the body significantly boosting heart health towards recovery. It is very effective in maintaining the physical integrity of the heart muscle. D-ribose naturally increases levels of ATP to improve cardiac contraction which in turn increases blood flow therefore allowing a faster recovery of the cardiac muscles following a heart attack. Moreover, D-ribose also plays a key supplemental role in managing ischemic heart diseases as there is deprived blood flow to the heart due to inadequate or weak heart contractions. The ATP production is increased to restore the cardiac tissue’s integrity by allowing more blood flow and resistance to fatigue.\n1. Coronary artery disease\n2. Stable and unstable angina\n3. Recovery from cardiac surgery or major cardiac event, such as heart attack\n4. Congestive heart failure and cardiac hypertrophy to promote diastolic cardiac function.\n5. Artial and ventricular arrhythmia\n6. Cardiac diagnosis to unmask hibernating myocardium\nRibose therapy directly supports the heart’s ability to preserve and rebuild its energy pool. Through this action, ribose helps the heart with the ATP it needs to perform its work.\nIschemic heart or vascular disease has a profound effect on tissue energy metabolism. The energy pool can be depressed as much as 40 percent in patients with chronic cardiac ischemia. D-ribose raises the energy level of the heart in chronically ischemic patients reduces fatigue, increases exercise tolerance and enhances quality of life.\nGiving ribose to patients both before (as a cardioprotective) and following (to restore lost energy) cardiac intervention has proven to be an effective way to improve clinical outcome. It helps the heart pump blood more easily and completely following the surgical intervention.\nD-ribose rebuilds the cellular energy pool, allowing the cell to better manage its calcium load, reducing nociceptor activation and outflow of potassium ions, modulating the pain and relaxing the muscle. D- ribose therapy in patients with fibromyalgia is very effective in lowering fatigue, reducing soreness and stiffness, and increasing patient quality of life.\nD-ribose increases the production of insulin, a hormone secreted by the pancreas that assists in the transport of glucose to the different organs in the body. Too much glucose in the body is generally not good and D-ribose has shown to have an inhibitory and regulatory effect on an enzyme called phosphoglucomutase secreted by the liver that breaks down glycogen (glucose stores in the body) thus lowering blood sugar levels.\nFibromyalgia is a severely debilitating condition characterized by chronic pain in certain locations in the body. D-ribose affects ATP synthesis which directly results in significantly decreasing muscle pain leading to a better quality of life.", "label": "Yes"}
{"text": "The North Carolina Division of Public Health is investigating 26 cases of E. coli in Wake (14), Sampson (6), Durham (1), Franklin (1), Johnston (1), Orange (1) and Wilson (1) counties. Ten of the cases are confirmed, and 16 are still under investigation. Five people – 4 children and 1 adult – are hospitalized. Twenty-three of the 26 outbreak victims attended the State Fair earlier this month.\nOther E. coli Lawsuits\nLawsuit updates about foodborne illnesses\nLawsuits updates by year\nAffected by an outbreak or recall?\nThe team at Marler Clark is here to answer all your questions. Find out if you’re eligible for a lawsuit, what questions to ask your doctor, and more.Get a free consultation\nWhat is E. coli and how does it cause food poisoning? Escherichia coli (E. coli) is a highly studied, common species of bacteria that belongs to the family Enterobacteriaceae, so...\nE. coli O157:H7 is a foodborne pathogen that causes food poisoning. E. coli O157:H7 is the most commonly identified and the most notorious Shiga toxin-producing E. coli (STEC) serotype in...\nNon-O157 Shiga Toxin-Producing E. coli can also cause food poisoning. E. coli O157:H7 may be the most notorious serotype of Shiga toxin-producing E. coli (STEC), but there are at least...\nWhere do E. coli O157:H7 and non-O157 Shiga toxin-producing E. coli (STEC) come from? The primary reservoirs, or ultimate sources, of E. coli O157:H7 and non-O157 STEC in nature are...\nWhile many dairy cattle-associated foodborne disease outbreaks are linked to raw milk and other raw dairy products (e.g., cheeses, butter, ice cream), dairy cattle still represent a source of contamination...\nLooking for a comprehensive list of outbreaks?\nThe team at Marler Clark is here to answer all your questions. Find out if you’re eligible for a lawsuit, what questions to ask your doctor, and more.\nView Outbreak Database", "label": "Yes"}
{"text": "Tourism–Carter Cave Natural Area\nThe land was donated to the Tennessee Department of Environment and Conservation in 1976. The area consists of 140 acres and protects a great geological feature of the area – Lost Cove Cave.\nThe main entrance to the cave system is the Buggytop Cave entrance. Thomas Barr, Jr. classified it as one of the most impressive cave mouths in the state.\nThe mouth itself is 100 feet wide and 80 feet high and opens at the base of a 150 foot high overhanging bluff. The stream that enters here cascades from the mouth dropping 40 feet in less than 100 yards.\nFrom the mouth of the cave, a cold draft of air blows in the summer. This draft can be felt in the creek valley nearly half a mile from the entrance.\nThe environment of the cave is very sensitive and visitors are asked to be careful not to disturb the environment. Rare and endangered species of salamanders and bats are found in the cave. All plants and animals in the area are protected by law, helping to preserve them for generations to come.", "label": "Yes"}
{"text": "- Evolution is the sequence of gradual changes which take place in the primitive organisms over millions of years to produce new species are produced.\n- Evolution can be defined as the changes in the genetic composition of a population with the passage of each generation.\n- Evolution may be small-scale or large-scale evolutions.\n- Small-scale evolutions refer to the changes in gene frequency and large-scale evolutions refer to different species having a common ancestor.\n- All the plants and animals (or organisms) which we see today around us have evolved from some or the other ancestors that lived on this earth long, long ago.\nEVOLUTION SHOULD NOT BE EQUATED WITH PROGRESS\n- Variation is the root cause of evolution that gives the organism better chance of survival in its habitat.\n- Evolution is not a ladder of progress but a by-chance process.\n- According to the concept of natural selection or ‘survival of the fittest’, individuals who are unfit were weeded out.\n- So, evolution deals with how an organism ensures its existence in its environment and is not about perfection.\n- Evolution is just the production of diversity of life forms and shaping of this diversity by the environmental selection.\n- The only progress in evolution appears to be that more and more complex body designs of organisms have emerged over the ages.\n- Evolutionis the progressive alteration in inherited traits over a large span of time, usually over generations due to environmental factors like temperature, climate, availability of resources, etc.\n- Evolution was necessitated when an organism required to utilize a niche and they were not able to do so with their existing body design or structural components.\nOrigin of Life on Earth\n- Evolution gives a better understanding about how the species became extinct, about their habitats and how new species are produced.\n- There is an inbuilt tendency to variation during reproduction process. T\n- The main responsible factors are the combination of genetic material from two parents and error in DNA copying during sexual reproduction.\n- Haldane also suggested from theoretical considerations that life (or living organisms) originated in the sea water.\nDifference between Change and Evolution\nChange may refer to the falling of leaves from trees, a human losing weight, hair fall, etc. But these do not play any sort of role in evolution. Only the changes that are passed down during genetic inheritance play a part in this transformation.\nTheory of evolution leads to the conclusion that all life on Earth shares a common ancestor who probably lived millions of years ago and gave rise to the immense diversity as it exists today. Evolutionary theory suggests that trees, humans, dolphins and everything else on this diverse planet are related.\nCauses and Mechanism\nThe mechanisms of evolution occur due to various reasons that focus on:\n- Variation, differential reproduction, and heredity result in evolutions by natural selection.\n- Different species affect each other evolution through co-evolution.\n- The heritable genetic differences which are carried to the next generation.\n- Four fundamental forces of evolution include natural selection, genetic drift, mutations, migration and gene flow.\nEvolution can occur due to various reasons. Natural selection is an advantage for survival that altered certain shared characteristics of the population, as the population might not have been exponential. So, some of their genetic frequency can be changed by near-fatal accidents in a small group of organisms, even when those offer no advantage for their survival. This concept of genetic drift is a process that causes diversity but not any survival adaptations.\nEVOLUTION AND CLASSIFICATION\nEvolution is the successive modification in inherited traits usually over generations that has resulted in a huge biodiversity. Classification is the way to handle these diversifying organisms.\nLiving organisms were classified based on characteristics like their similarities and dissimilarities. Characteristics are the appearance/form and behavior/function of something that decide which organism will belong to which group. For example, a dog has limbs but a snake does not. Also, both can move but a plant cannot. These are characteristics of different organisms and such behaviors classify them into different groups.\nThe cell is the fundamental unit of every organism and is a common characteristic of all living organisms. The number of organisms sharing common characteristics becomes lesser as we go up the levels. Thus, more the number of common characteristics shared between two species, more closely related they are and more recently they have had a common ancestor.", "label": "Yes"}
{"text": "Purchase this article with an account.\nZhipeng Chen, Zhong-Lin Lu, Fang Hou, Siyuan Deng, Shenglan Zhang, Jinrong Li; Assessing peripheral visual function in myopia – a qCSF study. Invest. Ophthalmol. Vis. Sci. 2019;60(9):4365.\nDownload citation file:\n© ARVO (1962-2015); The Authors (2016-present)\nThe peripheral retinal structure is very important in the pathogenesis and management of myopia. However, the quantitative relationship between peripheral visual function and myopia remains unknown. This study evaluated contrast sensitivity function in peripheral vision in myopia and emmetropia with the qCSF method.\nThe study recruited 19 myopia subjects (23.42±4.0 years) and 12 normal subjects (22.92±2.9 years). The average spherical and cylinder corrections were -2.95±3.26D and -0.03±0.74D in myopia group, and -0.34±0.52D and -0.30±0.42D in normal group. The BCVA was 0.00±0.00 logMAR in both groups. All subjects performed the qCSF test in foveal vision and fifteen peripheral locations (superior, inferior, temporal and nasal quadrants at 60, 120, 180 and 240 eccentricities, excluding the physiological scotoma at 180) and optical quality assessment with the double-pass Optical Quality Analysis System II, OQAS. The myopes wore soft contact lens with best corrected visual acuity (BCVA). To summary metrics, the cutoff spatial frequency (cut-off SF) and the area under log CSF (AULCSF), and contrast thresholds at 19 spatial frequencies (equally spaced in log units) at each of the 16 test locations were derived from qCSF test results.\nResults from the OQAS assessment found that there was no significant optical quality difference between two groups, including MTF cutoff, OV100%, OV20%, and OV9% and OSI (p>0.10). There was also no significant difference between two groups in any of the CSF metrics in foveal vision (p>0.10). Further analysis showed that myopes had significantly increased AULCSF in the superior (p=0.026), inferior (p=0.024) and nasal (p=0.022) quadrants at 120. Across the fifteen peripheral locations, there was no significant cut-off SF difference between two groups (p>0.10). In addition, contrast sensitivity in the myopia group was greater than that of normal group in the inferior quadrant at 60 (p<0.05), and the superior, inferior and nasal quadrants at 120 (p<0.05), but not at any of the other test locations.\nOur findings showed that, with best optical correction, the myopic visual system exhibited normal CSF in foveal vision but enhanced CSF in certain peripheral locations. We speculate that these results may be attributed to compensatory improvements of peripheral vision from its extensive use during near visual activities in the emmetropization process of myopic visual system.\nThis abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019.\nThis PDF is available to Subscribers Only", "label": "Yes"}
{"text": "Imaging and Morphology Support Core\nThe Imaging and Morphology Support Core of the ONPRC is designed to meet the imaging needs of ONPRC scientists and of the OHSU scientific community by providing state-of-the-art facilities, expertise, assistance and training in the use of advanced light microscopy, image analysis, and processing, and laser capture microdissection. Special emphasis is placed on quantitative evaluation of imaging experiments using both stereology and automated image analysis.\nSERVICESConsultation, training and access to instruments or full support by core personnel are offered for all services.\n- Fluorescence imaging: confocal, wide-field, and deconvolution microscopy\n- Special fluorescence techniques: FURA-2, FRET, FRAP, and live-cell time-lapse imaging\n- Large-area image montages: color brightfield or fluorescence, including 3D confocal\n- Neuron tracing and dendrites/spines analysis\n- Cell mapping\n- Image processing, 3D rendering, movies\n- Quantitative image analysis and stereology\n- Laser capture microdissection\n- Leica SP5 AOBS spectral confocal system with 5 excitation lasers (405, 458, 476, 488, 514, 561, 594, 633nm), motorized stage and stage-top microincubator.\n- Marianas Imaging Workstation with motorized stage, DG4 fluorescence illumination and the stereology, FURA and FRET packages\n- ArcturusXT laser capture microdissection system with UV cutting and fluorescence capability.\n- Neurolucida and StereInvestigator system equipped color brightfield and fluorescence.\n- CellSens, FIJI, Image J, Volocity, Slidebook\nACCESSThe Imaging and Morphology Support Core (IMSC) is a fee-for-service facility open to all ONPRC and OHSU investigators, and to the scientific community at large. Scientists interested in using the IMS Core may either get trained in using the available instruments or use assistance from core's personnel. Trained users may schedule independent instrument time on a web-based calendar. Core personnel are open to scientific collaborations. IMSC is located within ONPRC, on OHSU's West Campus.\nCONTACTSSathya Srinivasan, Ph.D., Director and Microscopy/Digital Imaging Specialist\nAshley White, B.S., Research Assistant", "label": "Yes"}
{"text": "Succulents — plants with thick, fleshy foliage and stems that store water — are by far the most common plants seen in terrariums. This makes a lot of sense, because succulents are typically comfortable not receiving too much water, and don’t need much root space to thrive, making them perfect for small enclosures. Plus, many species stay small and compact, allowing them to live for years in a terrarium without transplanting.\nHere’s how to care for this type of terrarium\n- Light: Save for some lower-light tolerant species like Haworthia and Gasteria, most succulents prefer bright, if not direct, light. Place your succulent terrarium in a very bright spot, keeping in mind that glass tends to magnify direct sun, and can potentially burn your plants.\n- Water: Succulents are drought tolerant plants, and are highly susceptible to root-rot. Combined with the fact that terrariums do not have drainage holes, you’ll want to water your succulent terrarium very sparingly, when the soil has gone almost completely dry. Water sparingly around the base of each plant using a watering can or a spray bottle. Most succulents will tell you when it’s time to water by puckering slightly in their leaves. This is a great indicator for when it’s time to water your terrarium\n- Troubleshooting: Shriveled leaves? Time to water. Mushy, brown or black leaves? You’re watering too much. Remove these plants and replace with comparable specimens, taking care not to water quite as much. Reduce watering during winter.", "label": "Yes"}
{"text": "According to a research report published by Azoth Analytics in March 2021, The Global Nucleic Acid Isolation and Purification market was valued at USD 3359.84 million in the year 2020. The rising demand of pure nucleic acids in pharmaceutical and biotechnological industries, and growing use of nucleic acid-based tests in diagnosis have propelled the growth of nucleic acid isolation and purification market across the globe. Moreover, increasing application of these techniques in various fields such as genetic engineering, life science research, forensics and molecular diagnostics and government funding in R&Ds and the recent technological innovations are expected to fuel the growth of this market.\nVarious companies are focusing on organic growth strategies such as product launches, product approvals and others such as patents and events. Inorganic growth strategies activities witnessed in the market were acquisitions, and partnership & collaborations. These activities have paved way for expansion of business and customer base of market players. The market payers from nucleic acid isolation and purification market are anticipated to lucrative growth opportunities in the future with the rising demand for nucleic acid isolation and purification in the global market.\nThe market for nucleic acid isolation and purification is expected to grow significantly in the coming years, owing to the key factors such as growing advancements in clinical diagnostic techniques, increasing public-private funding for life science research and increasing automation across the globe. Moreover, increasing demand for pure form of nucleic acid for drug delivery is likely to add novel opportunities for the global nucleic acid isolation and purification market over the forecast period.\nMoreover, in 2021, the Application based isolation and purification segment accounted for the largest share of the global nucleic acid isolation and purification market. This is more cost-effective, simpler, and faster which will propel the nucleic acid isolation and purification market in coming years due to increasing cases of various type of cancer disease.\nFurthermore, North America holds the leading position in the Nucleic Acid Isolation and Purification market followed by Europe. Asia Pacific is the most promising market for the growth of market due to the growth of emerging economies. With low penetration rates, the market is expected to hold major potential in the region, especially India and China, and hence the level of investments are huge in this region.\nThe Azoth Analytics research report ‘Global Nucleic Acid Isolation and Purification Market (2021 Edition)’ has analysed and segmented the Global Nucleic Acid Isolation and Purification Market by Value (USD Million). The report analyses Nucleic Acid Isolation and Purification Market By Product (High Kits, Reagents and Instruments), By Application (Diagnostics, Drug Discovery & Development, Personalized Medicine, Agriculture & Animal Research and Others) and By End User (Hospitals &Diagnostic Centers, Academic & Research Institutes, Pharmaceuticals & Biotechnology Companies and Others). The Global Nucleic Acid Isolation and Purification Market has been analysed By Region (North America, Europe, Asia Pacific And ROW) and By Country (United States, Canada, Germany, France, U.K, Italy, China, Japan, India and South Korea) for the historical period of 2016-2020 and the forecast period of 2021-2026.\nNo matter the hour, we’re here to help.Contact us now!", "label": "Yes"}
{"text": "Aflatoxins are a naturally occurring fungal toxins produced by the fungus Aspergillus flavus and are found in cereal grains, chilies, dry fruits and nuts. They are associated with health problems in livestock; in humans, they can cause stunting in children and cancer of the liver. Aflatoxin concentrations in harvested Pakistan grain often exceed the level permitted in countries where aflatoxin in food and feed is regulated.\nPakistan historically has had limited public awareness of the harmful effects of aflatoxin contamination. Recently, the U.S. Department of Agriculture (USDA) and the USAID Safer Food through Aflatoxin Control began work on the issue with Ingredion an American company processing 80 percent of the maize grown in Pakistan. The company had found contamination levels frequently above the international standard of 20 parts per billion, according to the World Health Organization.\nInternational scientific collaboration reaps dividends\nHow did a solution emerge to this problem? The short answer was close collaboration across geographic, institutional and public and private sectors.\nIn 2016, Ingredion’s Dr. Pushpak Mehta, a corn breeder, approached his former professor from Texas A&M University, Dr. Richard Frederiksen, a maize specialist. Frederiksen then directed him to Dr. Ranajit Bandyopadhyay, a professor then on sabbatical with Frederiksen (and head of an Africa-wide effort to develop an aflatoxin biocontrol mitigation technology, Aflasafe, for the Nigeria-based International Institute of Tropical Agriculture).\nBandyopadhyay introduced Mehta to his collaborator, Dr. Peter Cotty, a plant pathologist and leading scientist at USDA. Cotty had developed the groundbreaking biocontrol technology that would prove critical to helping Pakistan overcome its aflatoxin contamination.\nCotty and Mehta wasted no time and formed a partnership to identify a suitable biocontrol indigenous to Pakistan. USDA’s Pakistan Agriculture Program, a decade-long, USAID-funded program, also joined the effort, with Ingredion, to bring the technology to bear on the problem. USDA and Rafhan Maize (owned by Ingredion) began the crop sampling and laboratory research needed to identify the atoxigenic fungal strains of A. flavus native to Pakistan.\nIt was through these efforts that the formulated project, AflaPak, was born. AflaPak is a biological control agent/product for displacing the strains of aflatoxin producing A. flavus. The active ingredient in AflaPak is a naturally occurring, nontoxigenic strain of A. flavus.\nAflaPak takes off\nThe exceptional international collaboration that took place, and a decade of agricultural accomplishments across Pakistan, were documented in a three-part webinar held earlier this year. In the series of videos, experts shared how AflaPak came to fruition and how they are now registering the innovation with the government.\nIn the webinar, Mehta discussed Ingredion’s 2015 pledge to sustainably source 100 percent of multiple crops, including corn, which led to its 2016 investment in biocontrol technology in Pakistan and elsewhere.\nExpansion of AflaPak trials\nAccording to the Crop Disease Research Institute in Pakistan, the first field trial of AflaPak on 1,400 acres in 2019 demonstrated that aflatoxins could be reduced by 80 percent — a significant accomplishment. The Ingredion team expanded AflaPak trials in 2021 to 20,000 acres. This provided further credence to the technology’s effectiveness while encouraging its adoption in other southeast Asian countries and globally.\nDr. Hillary Mehl, a plant pathologist at the USDA Agricultural Research Service’s Aflatoxin Laboratory, works closely with governments and research organizations to expand the use of atoxigenic strains of Aspergillus flavus. USDA efforts here began in 2017 when her lab was provided with samples for genetic characterization and identified indigenous atoxigenic strains of Aspergillus flavus that have optimal biocontrol characteristics for Pakistan. Once a strain was selected for trial, Mehl and her partners trained laboratory personnel on appropriate methods for conducting field trials and analyzing maize samples.\n“Pakistan can adapt and adopt a technology that has been proven effective and addresses a major health and economic problem,” Mehl said.\nUSDA, USAID, Rafhan Maize, and other partners are now beginning a new phase of the aflatoxin control work by testing AflaPak’s efficacy on chilies. If AflaPak proves effective on another crop such as chili, it could save Pakistan years of research and development. Ingredion is committed to making AflaPak available for other crops, starting with chili. At the same time, USDA and its partners are continuing to build lab capacity and skills so that Pakistan will have the tools to develop aflatoxin biocontrols for other crops. Bangladesh is also interested in testing AflaPak on its crops, as was Afghanistan.", "label": "Yes"}
{"text": "|| 要旨トップ | 目次 |||日本生態学会第65回全国大会 (2018年3月、札幌) 講演要旨\n一般講演（ポスター発表） P3-076 （Poster presentation）\nA temporal strong wind is one component that damages the vascular systems of tree stems. In an area where a strong wind has blown, height growth by tree-stem elongation might be depressed due to a decrease in the water supplied to the elongating shoots. In Abies sachalinensis canopy trees, since seed cones grow in size and require water supply during the period of shoot elongation, height growth after a wind storm might be further depressed in years of seed-cone production. The relationship between seed-cone production and height growth was investigated for A. sachalinensis canopy trees in a cold temperate forest where strong winds (Typhoon Songda and a wind storm on November 27) were recorded in 2004. According to analyses using linear mixed models, both a depression in height growth and a negative effect of seed-cone production on height growth were detected during the period after the wind storms. On the other hand, according to analyses of each canopy tree, height growth is suggested to be sensitive to wind, even in trees with no damage to the canopy surface, but not substantially sensitive to seed-cone production, as compared to the wind.", "label": "Yes"}
{"text": "Biology Tutors in Hartford, CT\nFind Private & Affordable Biology Tutoring in the Hartford Area!\nColumbia - BA, Math\nFairleigh Dickinson University - BS, Marine Biology , Cornell University - Ph.D., Toxicology\nUniversity of Connecticut - Bachelors, Biology\nUniversity of Connecticut - BS, BS, Biological Sciences; Biological Sciences Education , University of Connecticut - MA, Curriculum and...\nUniversity of Connecticut - Bachelors, Ecology and Evolutionary Biology , University of Illinois at Urbana-Champaign - Masters, ...\nRice University - BS, Chemical Engineering\nUniversity of Connecticut - Bachelors, Biological Sciences\nKeene State College - Bachelors, Health Science: Nutrition\nUniversity of Connecticut - Current Undergrad, Biomedical Engineering\nB.S. Medical Technology M.S. Biology PhD Biology\nJunior East Asian Studies Major at Central Connecticut State, Associates degree in Liberal Arts, 3.6 GPA\nBS Biology and Psychology, minor: Neuroscience (University of Connecticut, 2011) MS Neuroscience (University of Hartford, 2013) PhD...\nMaster of Biology in Neuroscience at University of Hartford. GPA 3.8 Bachelor of Science in Psychology, Minor in Biology; State...\nBachelor of Science in Education from the University of Connecticut, Storrs Graduated May 2009", "label": "Yes"}
{"text": "According to LiveScience, Kingsnakes are medium-size snakes with no venom. Contrary to other snakes, they kill their prey by constricting other animals and squeezing them until they die.\nKaren Vick Scarbrough, from the city of Camden, in Alabama, witnessed it for the first time in her yard where two snakes were fighting. As her dog was barking, she ran to the backyard to check what was happening. To her surprise, a copperhead snake and a kingsnake were fighting.\n“We were shocked when we realized it was two snakes. The entire encounter lasted roughly an hour from the time we saw the two snakes until the kingsnake had completely eaten the copperhead.” Karen said, according to MSN.\nKaren shared with her family and friends on Facebook several pictures and footage of the scene. More than 2.9k people shared her post, 323 liked it and she received 35 comments.\n“I’ve heard of this and seen pictures but I’ve never seen it myself,” Karen wrote in her post.\nDuring the snake fight, the nonvenomous kingsnake was able to eat the copperhead. Copperheads are typically between two and three feet in length. They are found in the southern and eastern parts of the United States.\nWhile the copperhead is known to be a large venomous snake, the kingsnake is immune to his bites and is known to be his predator to copperheads. Kingsnakes eat lizards, birds, eggs, and turtle eggs. They don’t need food every day, especially after a big meal. They are mainly active during the day and like to hide under things.\nAlabama Wildlife and Freshwater Fisheries Division shared Karen’s Facebook footage writing: “This is what happens when you bring a copperhead to a kingsnake fight.”\nNo wonder why kingsnakes are called kingsnakes because other snakes, including the most venomous ones, are their main source of food every day!", "label": "Yes"}
{"text": "NOW Supplements, Vitamin C-1,000 with Rose Hips, Sustained Release, Antioxidant Protection*, 100 Tablets\n- SUSTAINED RELEASE: NOW Vitamin C-1000 was specially formulated to provide a sustained release of vitamin C, known for its vital role in the immune system\n- WITH ROSE HIPS: Added source of vitamin C\n- CERTIFICATIONS/CLASSIFICATIONS: Vegan/Vegetarian, Quality GMP Assured, Non-GMO, Soy Free, Kosher\n- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).\n- Packaged in the USA by a family owned and operated company since 1968\n|Settings||NOW Supplements, Vitamin C-1,000 with Rose Hips, Sustained Release, Antioxidant Protection*, 100 Tablets remove||Nutricost Tudca 250mg, 60 Capsules remove||Puritan's Pride Absorbable Calcium 600mg Plus Magnesium 300mg & Vitamin D 1000iu-60 Softgels remove||Vitabiotics Feroglobin 30 Capsules remove||Puritan's Pride Garcinia Cambogia Vegetable Capsules, 1000mg, 60 Count remove||Now Foods GABA - 500 mg - 100 Vegetarian Capsules remove|\nOut of stock\n8 in stock\n10 in stock\n|Availability||Out of stock||8 in stock||10 in stock|\n|Add to cart|\nBone-Active Bone Density Supplement\nAt any age, bone health is important. Puritans Pride Absorbable Calcium with Magnesium Vitamin D contains Bone-Active bone density supplement. Formulated to help maintain bone strength and density, this supplement aims to help support optimal bone health. Calcium is the primary mineral responsible for strong bones and teeth. Magnesium is essential for calcium transport and absorption, but many of our diets are lacking the right amounts of this essential mineral. Magnesium absorption decreases in older adults. Calcium and Magnesium each play an essential role in maintaining bone health.and,and, Plus, each softgel is fortified with Vitamin D. Calcium and Vitamin D help maintain healthy bones in adults.\nIron is a mineral that the body needs for growth and development. Your body uses iron to make hemoglobin, a protein in red blood cells that carries oxygen from the lungs to all parts of the body, and myoglobin, a protein that provides oxygen to muscles.\nVitamin B complex helps prevent infections and helps support or promote:\nThere are no reviews yet.", "label": "Yes"}
{"text": "Description of Breast Angiosarcoma:\nA breast angiosarcoma is a rare type of breast cancer which starts in cells that line the blood vessels within your breast or underarm area. It can occur due to breast and upper arm radiation\ntreatments, and is apt to grow and spread quickly. Breast angiosarcoma may at first appear similar to a skin rash, infection, or bruising.\nA Rare Breast Cancer Diagnosis:\nis a type of cancer that grows in soft or connective tissue, and an angiosarcoma can occur in any organ of your body. Less than 10% of all angiosarcomas originate in the breast. Angiosarcoma of the breast accounts for about 0.04%, or one in 2,500 cases of all breast cancer diagnoses.\nPrimary and Secondary Breast Angiosarcoma:\nPrimary angiosarcoma of the breast is usually diagnosed in young women, between the ages of 20 to 40. These primary cancers show up as an ill-defined mass in the breast. Secondary angiosarcoma is often diagnosed in women over 40, 5 to 10 years after they have had radiation treatment for breast cancer. The American Cancer Society states that angiosarcoma is a very rare complication of breast radiation.\nWomen who developed lymphedema\nas a result of lymph node removal may also be diagnosed with angiosarcoma, particularly if their underarm area received radiation.\nAlso Known As:\nAngiosarcoma of the breast, mammary angiosarcoma, haemangiosarcoma of the breast, lymphangiosarcoma (if occurs in lymph node area)\nSigns and Symptoms of Breast Angiosarcoma:\nPrimary angiosarcoma (diagnosed in a patient who has never had breast cancer) may feel like a thickened area of the breast. In some cases, the nearby skin may turn blue or reddish and appear to have a rash, or to be bruised. Secondary angiosarcoma (diagnosed in a patient who has already been treated for breast cancer) may feel like a hard, painless mass in the breast, skin may be blue or red over the mass, and there may be some swelling and bumpiness to some tumors. Some patients report feeling a tender, or even painful breast mass, depending on the size of the tumor.\nTests Used to Diagnose Breast Angiosarcoma:\n- Mammogram – an angiosarcoma will appear to have a fuzzy outline and will not have spiky protrusions (spikes are commonly seen on carcinomas)\n- Ultrasound - an angiosarcoma will show up well on an ultrasound, with clear borders that may be bumpy\n- Breast MRI – this type of tumor will show up on an MRI, revealing the affected blood vessels and surrounding tissue\n- Skin punch biopsy – a sample of affected skin will be taken and given a careful examination in the lab, to distinguish this from other, similar cancers\n- Open surgical biopsy – to get a larger sample of skin and tumor for lab testing\nAngiosarcoma Grows and Spreads Quickly:\nThis type of breast cancer is aggressive, and your prognosis will depend on the stage at which it is caught, how far it has spread at the time of diagnosis, and how aggressively it is treated. Angiosarcoma of the breast can spread through your blood system to your lungs, liver, bones, skin, and your other breast. Your brain, ovaries, and lymph nodes may also be affected by the metastasis of angiosarcoma. This type of breast cancer has a high rate of recurrence. A diagnosis of breast angiosarcoma usually has a poor prognosis, and only 10% to 27% of patients will survive this cancer by 5 years.\nTreatments for Breast Angiosarcoma:\n- Lumpectomy – surgery to remove the tumor and a wide margin of surrounding tissue (helps prevent recurrence)\n- Mastectomy – surgery to remove all of the breast tissue\n- Chemotherapy – most angiosarcomas will not benefit from chemo, but some may\nOutlook on Prevention and Treatment:\nResearch is being done on new ways to treat angiosarcoma of the breast, so that it may be better controlled, providing patients with better survival and quality of life. Hyperfractionated irradiation (smaller, more frequent doses of radiation) may help prevent local recurrence. Hyperthermia (treating tumors with heat), interleukin-2 (a drug that boosts your immune system), and anti-angiogenesis therapy (such as Avastin\n), are considered experimental treatments and are available only in a clinical trial at this time.", "label": "Yes"}
{"text": "Mazao CAMPAIGN is an easy to apply insect-killing fungus that occurs naturally in the soil.\nAn Organic Solution for the control of\nMazao CAMPAIGN ® composed of an insect killing fungus found in soil named Metarhizium anisopliae strain ICIPE 69\nWhy Use Mazao CAMPAIGN?\n1. Effective on mealybugs, whiteflies, thrips and fruit flies\n2. Can be tank mixed with insecticides and foliar fertilizers.\n3. Safe to user and environment\n4. Zero PHI (post-harvest interval)\n5. Zero Residue Levels\nMazao CAMPAIGN is produced by REAL IPM Kenya.", "label": "Yes"}
{"text": "Chandaka Elephant national park is situated out skirts of Bhubneshwar, the capital of Orissa, covers an area of 193 sq km. It is a unique park of its kind located around ever green forest of Khurda Uplands. The park is established in 1982, and a centre of attractions\nThe fauna of the park include from semi evergreen, to the moist kangada forests, coastal sal forest, thorny bamboo brakes, planted teak and eupatorium scrub. The park falls in sub tropical regions, thus, a home to the many other plants such as medicinal herbs, bamboos, with a few orchids which provide shade and food for the elephant.\nThe dense, mangrove and thickly evergreen vegetation provide shelter to 30 species of mammals, 27 species of reptiles and 120 species of birds. The park gives an ideal destination to the elephant and watching them in their natural habitat sleeping in shade or plying with water in the lake is really an amazing feeling. Apart from the elephant, you can explore leopard, chital, barking deer, mouse deer, langur, rhesus monkey, mongoose, sloth bear, wolf and hyena. There are many other reptiles found in the park such as snakes, python, monitor lizard and crocodiles. If you are fond of bird, you should visit the park in January and February, it is the perfect time to explore the beauty of many endangered species of birds for instance storks, heron, egrets and cormorants, Garganey and common teal, pin tail, white eyed Pochard and spot billed Duck.\nThe Chandaka national park has more than three watch towers from where one can enjoy and explore the virgin flora and fauna of the wildlife sanctuary.", "label": "Yes"}
{"text": "VIC WormBoss Worm Control Programs\nVIC WormBoss Drench Decision Guides\nLivestock Logic Key Recommendations\nConditions in the south west of the state were great over winter with only moderate rainfall and plenty of warm conditions perfect for growing grass. As a result, livestock have thrived and early lamb marking results would suggest lamb survival, for June in particular, has benefited. The concern is how dry it is for this climate at this time of year and we are all hoping for a wet August/September as soil moisture levels are well below where they would normally be in late July.\nWe continue to see a high number of cases of hypocalcaemia in both sheep and cattle that is a direct result of the drought last year. It is important for producers to be feeding out hay particularly to late gestation and lactating sheep and cattle with increased emphasis during periods of inclement weather.\nThe below chart shows how worm egg counts in the South West of Victoria have risen sharply in July and we would expect the number of weaners needing drenching in August to continue to rise. This increases the need for regular monitoring during the winter months and spring.", "label": "Yes"}
{"text": "Test performance in particular histopathologic forms of thyroid nodules is introduced in Table 2. Among nodules discovered to be benign after surgery, the take a look at appropriately categorised as negative eighty four of ninety five (88%) hyperplastic follicular cell nodules, 5 of 5 (100%) hyperplastic Hürthle cell nodules, 37 of 47 (seventy nine%) follicular adenomas, and 21 of 34 (62%) Hürthle cell adenomas. In a subgroup of histologically benign nodules with Bethesda III-IV cytology, 146 of 179 (eighty two%) had been categorised as adverse.\nProspective And Retrospective Cohort Studies\nResearchers measured areas under the curve , sensitivity, and specify for four glaucoma indicators (ATX, TGF-β1, TGF-β2, and TGF-βthree). Results from a potential observational examine showed aqueous transforming development issue beta (TGF-β) and autotaxin exhibited excessive diagnostic efficiency in detecting glaucoma subtypes and could function promising biomarkers for glaucoma. Results from a prospective observational research showed aqueous remodeling development factor beta and autotaxin exhibited high diagnostic performance in detecting glaucoma subtypes and could serve as promising biomarkers for glaucoma. The Canadian COVID-19 Prospective Cohort Study is the first Canadian study to supply a comprehensive evaluation of early to 1-yr outcomes in sufferers with COVID-19 and their family caregivers. A number of previous studies have shown oleandrin’s capacity to cross the blood-mind-barrier when the drug is administered orally. Collaborative work with Duke University discovered that PBI was efficient orally in opposition to stoke mediated ischemic injury. The analysis found an increase in production of the critically important mind development issue … Read More", "label": "Yes"}
{"text": "Legionnaires' Disease Outbreak In Disneyland Results In Shutdown Of Two Cooling Towers\nTwo water cooling towers located in the backstage area of the Disneyland in Anaheim were shut down after multiple incidents of Legionnaires disease were reported.\nIn unsettling Disneyland news, two water cooling towers located in the backstage area of the park have been shut down after multiple incidents of Legionnaires disease were reported. According to the Los Angeles Times, twelve cases of the severe lung disease caused by exposure to contaminated water or mist were discovered three weeks ago—nine of which involved people who had spent time at Disneyland in September. The other two individuals had spent time in Anaheim, the city in which the park is located.\nRanging in age from 52-94, ten of the individuals affected by the bacteria-contaminated cooling towers were hospitalized. According to the LA Times, one of the two individuals who had not been to Disneyland but contracted the disease and had a medical history of \"additional health issues\" died. (According to the CDC, about one out of every 10 people who get sick from Legionnaires’ disease will die.)\nAlthough the disease is not contagious or transmitted person-to-person, it grows and spreads in human-made water systems. Those who have Legionnaires disease often face pneumonia-like symptoms, including high fever, chills, and a cough.\nIn a statement on the Disney Parks blog, Pamela Hymel, Chief Medical Officer for Walt Disney Parks and Resorts, wrote: \"Upon being notified by OCHCA about the increased cases of Legionnaires’ disease in Anaheim, we worked closely with health care officials to see if there were potential areas of concern. We reviewed our water quality testing data, including testing performed by our third-party water quality maintenance contractor, and learned that two cooling towers had elevated levels of Legionella bacteria. These towers were treated with chemicals that destroy the bacteria and are currently shut down to further eliminate any ongoing concern. We have proactively shared this information with OCHCA and, given our actions, they have indicated there is no longer any known risk associated with our facilities.\"\nThe statement continued: \"While there is no ongoing concern at Disneyland Resort, we are committed to providing a safe and healthy environment for all who visit or work at our parks and resorts. If you have further questions about Legionnaires’ disease, I encourage you to visit https://www.cdc.gov/legionella/index.html.\"", "label": "Yes"}
{"text": "We believe in transparent processes starting my girls on a half kibble, half homemade food. Table 2 Taurine Amounts in Foods. I have been thinking of. Tail Blazers Pets – Blog.\nDespite the fact that the health effects of taurine are largely unknown, taurine has become a popular supplement and ingredient in energy drinks in recent years. J Nutr. Human studies The effects of taurine on lipid levels were examined in several small randomized trials Table 3. However, it is unknown whether the beneficial dieet of taurine would only be seen among individuals with high-fat diet. For correspondence and requests for reprints: Dr.\nClin Nutr. It was very informative and helpful. Evidence from mechanistic diet animal studies has shown that ciet main biological actions of taurine include its ability to conjugate bile acids, regulate blood pressure BP, and act as a potent antioxidant taurine anti-inflammatory agent. Schuller-Levis How, Park E. Stability over time could be an issue. It means the diet meets the minimal standards, not optimal standards. You could taaurine do both as well because there is no such thing get too much taurine.", "label": "Yes"}
{"text": "Probiotics are beneficial bacteria that support digestive and immune health.*\n✓ Supports normal bowel function*\n✓ Promotes immune function*\n✓ Helps support women's urinary tract and flora health*\nSpring Valley™ Women's Probiotic supports a healthy balance of beneficial bacteria in the digestive system, promoting digestive, urinary and immune health.* For maximum effectiveness, this product has been formulated with probiotic strains that are resistant to stomach acids.\n• Formulated for daily use\n• Naturally supports healthy intestinal flora balance*\n• Provides 1 billion active cultures per capsule†\n• Includes inulin prebiotic fibers that support the growth of good bacteria in the digestive system\n• Contains 8 high potency probiotic strains*\nWhat are Probiotics?\nThe human digestive system is home to trillions of bacteria that perform many helpful functions. However, the healthy balance of good bacteria can be disrupted by diet, travel or stress. Probiotics are beneficial bacteria that can help replenish and support a healthy balance. Probiotic species are different types of bacteria, each of which may provide different health benefits.*\n*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\n†Contains a minimum of 1 billion live bacteria cells per capsule at time of consumption, if prior to expiration, under recommended storage conditions.\nSpring Valley Women's Probiotic Dietary Supplement are specially formulated to promote the digestive, urinary, and immune health of women by supporting a healthy balance of beneficial bacteria in the digestive system. The human digestive system is home to trillions of bacteria that perform helpful functions. Stress, travel, and bad diets can disrupt your body's healthy bacterial balance. These probiotic vegetable capsules are allergen-free and help support the growth of beneficial bacteria that replenish and support a healthy intestinal flora balance. This product has been formulated with probiotic strains that are resistant to stomach acids for maximum effectiveness. With 8 high potency probiotic strains and 125 milligrams of cranberry extract per capsule, you'll be on the path to better health with just one Spring Valley Women's Probiotic Dietary Supplement per day.\nSpring Valley understands living a healthy, balanced lifestyle is the key to being your best self. With an affordable range of products inspired by nature, Spring Valley supports your and your family's health and holistic wellbeing.\n- Promotes digestive, urinary, and immune system health\n- Supports normal bowel function\n- Contains cranberry extract\n- Provides 1 billion active cultures per capsule\n- Resistant to stomach acids\n- Allergen free\n- Contains prebiotic inulin and 8 probiotic strains\n- 30 vegetable capsules\nHealth Concern: Digestive Health Urinary Tract Support Digestive Concern\nInactive Ingredients: Other Ingredients: Starch, Maltodextrin, Hypromellose, Inulin, Magnesium Stearate, Titanium Dioxide, Ascorbic Acid (as preservative)\nIngredients: Other Ingredients:<br>Starch, Maltodextrin, Hypromellose, Inulin, Magnesium Stearate, Titanium Dioxide, Ascorbic Acid (As Preservative).\nDosage: Suggested Use: Women age 12 and older, take one capsule daily with a meal.\nInstructions: KEEP OUT OF REACH OF CHILDREN. **FOR YOUR PROTECTION, DO NOT USE IF SEAL IS BROKEN.", "label": "Yes"}
{"text": "Background: To describe characteristics and outcomes among lung transplantation (LT) patients with respiratory syncytial virus (RSV) infection and elucidate the predictors of 1-year survival after RSV infection. Methods: This was a retrospective chart review study among LT patients with RSV infection between 2013 and 2018 (90 episodes among 87 patients; mean age 56.3 ± 13.1 years, M:F 52:35). A contemporaneous control group consisting of LT patients without RSV infection (n = 183) was included. One-year survival after the RSV infection was the primary endpoint. Results: Median time from LT to RSV infection was 30 (1-155) months. Before RSV infection, the median decline in forced vital capacity (FVC) was 9.7 cc (−17.8 to 83 cc) or 0.29% (−1.4% to 4.6%) per month, while the forced expiratory volume (FEV1) decline was 7.5 cc (−8.8 to 58 cc) or 0.3% (−0.57% to 4.3%) per month with no statistically significant change after RSV infection. One-year survival among patients with RSV infection was 86.2% (75/87). Pre-infection diagnosis of chronic lung allograft dysfunction (CLAD; adjusted HR: 4.29, 1.08-17.0; P =.038) and FVC or FEV1 decline >10% during 6 months post infection (adjusted HR: 35.1, 3.26-377.1; P =.003) were independently associated with worse survival. On propensity score matched analysis, RSV infection was not associated with worse post-transplant survival (HR with 95% CI: 0.79, 0.47-1.34; P =.38). Conclusions: A majority of LT patients in the current cohort did not experience an alteration in the trajectory of FVC or FEV1 decline after developing RSV infection, and their post-transplant survival was not adversely impacted. Established CLAD at the time of RSV infection and post infection >10% decline in FVC or FEV1 are independently associated with worse survival after RSV infection.\n- chronic lung allograft dysfunction\n- community-acquired respiratory virus infections\n- multiplex PCR\nASJC Scopus subject areas\n- Infectious Diseases", "label": "Yes"}
{"text": "Growing orchids can be a rewarding experience, bringing a touch of exotic beauty to your living spaces. Orchid enthusiasts often look forward to the blooming stage when vibrant flowers come alive, showcasing the plant’s true splendor. However, questions about how often orchids bloom and how to care for them during the blooming stage often arise. This comprehensive guide provides detailed information about the blooming stage of orchid growth and tips for maintaining your orchids during this crucial period.\nGrowing Orchids (Blooming Stage)\nThe blooming stage is the peak of an orchid’s growth cycle, characterized by vibrant and ornate flowers that make these plants so loved. Ensuring optimal conditions during this stage can significantly affect the duration and beauty of the blooms.\nWatering and Sunlight\nBalanced watering is key for orchids, especially during the blooming stage. Overwatering or underwatering can stress the plant, reducing the quality and lifespan of the blooms. Generally, orchids should be watered once a week, but this can vary based on the type of orchid, the potting medium, and the environment.\nIt’s best to water orchids in the morning, giving them enough time to dry before nighttime. The goal is to keep the roots moist but not soggy. Always ensure the pot has good drainage to prevent water from stagnating, which may lead to root rot and other diseases.\nOrchids need plenty of light to bloom but can be sensitive to harsh, direct sunlight. During the blooming stage, orchids thrive under bright, indirect light. Placing them near a north or east-facing window is typically a good choice.\nHowever, care should be taken to protect the orchids from scorching afternoon sun, which can burn the leaves. If the leaves of your orchid become a dark green color, it may be a sign they are not receiving enough light. Conversely, reddish-green leaves could indicate too much direct sunlight.\nChoosing the right type of fertilizer is crucial for nourishing orchids during their blooming stage. A balanced, water-soluble fertilizer with equal parts of nitrogen, phosphorous, and potassium is generally recommended for most orchid varieties. This well-rounded fertilizer provides the essential nutrients for healthy growth and vibrant blooms.\nYou may also consider using a bloom-booster fertilizer for an extra boost during the blooming stage. This specialized fertilizer is formulated with a slightly lower nitrogen and higher phosphorus content. The increased phosphorus aids in the development of flowers, promoting more abundant and beautiful blooms. By providing this additional nutrient during the blooming phase, you can help your orchids reach their full blooming potential and showcase their natural beauty.\nFrequency of Fertilizing\nLike watering, orchids require consistent fertilization to maintain optimal health and promote growth. It is especially crucial to meet their nutrient requirements during the blooming stage. Consider fertilizing every week or two to provide the necessary nourishment.\nBefore applying the fertilizer, make sure to water the orchids thoroughly. This step is important to prevent root burn and ensure proper absorption of nutrients. Additionally, following the manufacturer’s instructions when preparing the fertilizer solution is essential. This will help guarantee the correct concentration and maximize the benefits for your orchids. Paying attention to these details ensures that your orchids thrive and flourish in their environment.\nThe flowering or blooming stage is the highlight of growing orchids. During this time, the plant puts forth its energy into producing flowers, resulting in the breathtaking display that orchids are known for.\nThe blooming duration can vary depending on the orchid species and the care provided. An orchid bloom can last from several weeks to several months. Some orchid types, like Phalaenopsis (moth orchids), can bloom for up to three months under optimal conditions.\nFactors such as adequate lighting, proper watering, and feeding can all influence the longevity of the blooms. Providing consistent care throughout the blooming stage can help ensure the flowers last for their full potential duration.\nMaintaining the right conditions for your orchids can prolong their bloom time.\nUnderstanding Orchids: The Importance of Temperature\nTemperature plays a significant role in the life of an orchid. Orchids, predominantly tropical plants, often prefer a temperature range that mirrors their native habitats. Most orchids thrive in daytime temperatures of 70 to 80 degrees Fahrenheit. This warmth promotes active growth, assisting in developing lush foliage and potential flower spikes.\nHowever, the temperature requirement can vary depending on the type of orchid. Some orchids, like Dendrobiums and Vandas, prefer warmer conditions, whereas others, like Cymbidiums and Odontoglossums, can tolerate cooler temperatures. Understanding the specific temperature needs of your orchid species is key to its successful cultivation.\nNight and Day: Navigating Temperature Drops\nInterestingly, while orchids generally require warm temperatures during the day, most species enjoy a significant drop of about 10 to 15 degrees at night. This fluctuation mimics the orchids’ natural habitat, where tropical days give way to cooler nights and aid in flowering.\nCreating a similar temperature variation at home can encourage flower bud development in your orchid. This can be achieved by moving your orchids to a cooler room at night or increasing the air conditioning during the summer months. Remember, however, that abrupt or extreme temperature changes can harm your orchid, so aim for gradual day-night transitions.\nHumidity: A Crucial Factor in Orchid Care\nHumidity, or the amount of moisture in the air, is another crucial factor in the overall well-being of orchids. In their natural habitat, orchids experience high humidity levels. Most orchid species prefer a humidity level of about 40 to 60 percent.\nLow humidity can lead to dehydration, causing symptoms like wilting flowers and yellowing leaves. On the other hand, excessively high humidity can encourage mold and fungal growth. Monitoring and adjusting humidity levels as needed can significantly affect the health and vitality of your orchid.\nClever Hacks: Increasing Humidity for Your Orchids\nMaintaining the desired humidity levels for orchids can be challenging in indoor environments, especially in dry or air-conditioned rooms. A simple and effective way to increase humidity levels is to place your orchid pot on a tray filled with water and pebbles. The water evaporating from the tray increases the moisture around the plant without causing waterlogging.\nOther methods to increase humidity include using a humidifier, grouping plants, or placing water containers around the room. Regular misting of the plant can also help, but care should be taken to prevent water from settling in the plant’s crown, which can lead to rot.\nA Holistic Approach: Other Factors for Optimal Conditions\nWhile temperature and humidity are critical for orchid care, other environmental factors also create optimal conditions. Aspects like air circulation, light quality, and potting media significantly impact the health and blooming of your orchids.\nProper air circulation can prevent the buildup of stagnant moisture and decrease the risk of diseases, while the right light quality and intensity are vital for growth and flowering. Choosing the right potting media can ensure healthy root development and adequate water provision. Every element in the orchid’s environment contributes to its overall health and success as a blooming plant.\nPruning is an essential part of orchid care during the blooming stage. Not only can it affect the aesthetic appeal of your plant, but it can also influence the possibility of future blooms.\nPurpose of Pruning\nPruning serves several purposes during the blooming stage. For one, it involves the removal of spent blooms, which can help divert the plant’s energy to new growth. Dead or damaged parts should also be removed to prevent diseases from spreading to healthy parts of the plant.\nWhen an orchid has finished blooming, the flower spike should be pruned to allow the plant to focus on growing healthy leaves and roots in preparation for the next blooming cycle. In some cases, particularly with Phalaenopsis orchids, a secondary spike may develop from the nodes on the existing spike if it is cut above a node.\nInvesting in Quality: Choosing the Right Pruning Tools\nA successful pruning starts with the right tool. A pair of sharp, clean pruning shears or a razor blade for more delicate plants is often ideal for orchids. The cutting tool should be able to make clean and precise cuts without crushing the orchid stem. Having a tool that is comfortable to hold ensures control and precision during the pruning process.\nTiming: Deciding When to Prune Your Orchid\nKnowing when to prune your orchid is as important as knowing how. The best time to prune depends on the plant’s health and stage of growth. For instance, flower spikes should typically be pruned when they have finished blooming, all the flowers have fallen off, and the spike has turned brown or yellow. On the other hand, dead or diseased parts should be removed as soon as they are noticed.\nThe Cutting Process: Mastering Pruning Techniques\nUnderstanding the correct way to cut your orchid is crucial. For flower spikes, make a clean cut about an inch above the node from where the flowers bloomed. Always cut at an angle to prevent water from pooling on the cut surface, which can lead to rot. If all the flowers have fallen off and the spike has turned brown, it should be cut near the base of the plant.\nPlant Health: Addressing Disease Through Pruning\nIn the case of dead, diseased, or damaged parts, these should be removed carefully without affecting the healthy parts of the orchid. This not only improves the aesthetic appearance of the plant but also prevents the spread of disease. Pruning such parts can help redirect the plant’s energy towards healthy growth and blooming.\nAftercare Measures: Caring for Your Orchid Post-Pruning\nOnce the pruning is done, the aftercare begins. Immediately after pruning, it’s recommended to apply a fungicide to the cut areas to prevent infections. Ensure the orchid is placed in a stress-free environment with proper light, temperature, and humidity conditions to recover from the pruning process. Regularly check the pruned areas to ensure they are healing correctly, and watch for any signs of disease or distress.\nHow Often Do Orchids Bloom?\nThe frequency of orchid blooming can vary based on several factors. Understanding these can help you set realistic expectations and provide appropriate care to encourage blooming.\nDifferent species of orchids have different blooming frequencies. Some orchids bloom once a year, while others can bloom multiple times. For example, Phalaenopsis orchids can rebloom up to 2-3 times a year if given proper care.\nRemember that young orchid plants may not bloom as frequently or as profusely as mature ones. Patience and consistent care are important as your orchid grows and matures.\nYour orchid’s surrounding environment significantly impacts the blooming frequency and overall health of the plant. Understanding these factors and adjusting your care routine is essential for a successful blooming stage.\nThe Essentials: Light, Temperature, and Humidity\nAdequate light, the correct temperature, and appropriate humidity conditions are all vital elements for an orchid to thrive and bloom. Orchids generally prefer bright, indirect light. Too much direct sunlight can scorch the leaves, while too little can lead to weak growth and poor or no blooming.\nTemperature requirements can vary among orchid species, but most prefer a significant drop in temperature at night compared to daytime temperatures. This variation helps trigger the plant to produce flower buds.\nHumidity is another crucial factor, with many orchids favoring about 40 to 60 percent. However, while high humidity levels can benefit the plant, they can also encourage mold and fungus growth. Therefore, good air circulation is also important to keep these issues in check.\nThe Importance of Rest: Understanding Dormancy\nLike many other plants, orchids also need rest or dormancy to prepare for the next blooming cycle. This dormant period typically follows the blooming stage. During this time, the plant focuses on root growth and nutrient storage for the next cycle.\nWatering and feeding should be reduced during dormancy, and the plant should be kept in cooler conditions. Remember not to confuse this period with the plant being sick or dead – a common mistake among novice orchid growers. Failing to provide this dormant period may disrupt the plant’s natural cycle and potentially affect the blooming frequency of your orchid.\nOrchids are a delight to grow, especially when they reward your care and patience with their spectacular blooms. By providing consistent care and maintaining optimal conditions during the blooming stage, you can enjoy the beauty of orchid flowers for many weeks.\nHowever, remember that the frequency and duration of blooming can vary significantly depending on the species of orchid and environmental factors. Some orchids bloom once a year, while others may bloom several times a year when given ideal conditions.\nThe importance of consistent care, even when the plant isn’t blooming, should not be overlooked. Supporting your orchid’s overall health and well-being, such as maintaining a balanced watering routine, providing adequate sunlight, feeding it with appropriate fertilizers, and ensuring proper pruning practices, all contribute to a successful blooming stage.", "label": "Yes"}
{"text": "Lipocalin-type prostaglandin D synthase in semen has been associated with male fertility, although this relationship is not well defined. To gain insight into potential mechanisms, the objective of the present study was to immunocytochemically localize lipocalin-type prostaglandin D synthase within the testis, efferent ducts, and 4 segments of mouse epididymis. In the testis, immunoperoxidase staining was localized within the Sertoli cells only at stages VI-VIII of the spermatogenic cycle, which is just prior to spermiation. Intense staining was also evident throughout the interstitial tissue, including Leydig cells. The entire epithelium of the efferent ducts, including ciliated and nonciliated cells, was immunoreactive. A distinct pattern of immunostaining for lipocalin-type prostaglandin D synthase was observed in different regions of epididymis, suggesting a possible role in sperm maturation. Staining for lipocalin-type prostaglandin D synthase was strikingly absent in the initial segment. In caput epididymidis, staining was evident throughout the cell cytoplasm of principal cells with some cells more intensely stained than adjacent ones. In the corpus region, overall staining intensity decreased and appeared to be concentrated in the apical region of principal cells, but some cells were completely unreactive. Reaction product in the cauda region was heavily concentrated on microvilli and within the epididymal lumen. In all epididymal regions, expression of lipocalin-type prostaglandin D synthase was specific to epithelial principal cells; no immunoreactivity was apparent in other cell types. The specific localization of lipocalin-type prostaglandin D synthase within the testicular interstitial tissue, Sertoli cells, and principal cells of caput epididymidis strongly suggests that this protein plays an integral role in both the development and maturation of sperm.", "label": "Yes"}
{"text": "The Cost of Tobacco.\nMake It Your Business.\nTobacco use can contribute to:\n- Greater healthcare costs\n- Increased absenteeism\n- More or longer breaks on work time\n- Higher life insurance premiums\n- Greater risk of occupational injuries\n- Costlier disability benefits\n- Increased property insurance\nDid you know? In Oklahoma, smoking-caused productivity losses alone cost businesses $2.1 billion, and healthcare costs directly caused by smoking totals $1.62 billion.\nSo, how much is smoking costing your business?\nLet’s add it up.\nThis handy Cost Calculator will give you a clearer view of how much extra you’re paying in healthcare costs and lost productivity due to smoking. Simply follow the prompts below and the Cost Calculator will do the rest.\nSmoking is the main cause of Chronic Obstructive Pulmonary Disease (COPD), an incurable lung disease. It results in shortness of breath, coughing, swollen airways, scar tissue and death.\nAsthma is another serious breathing disorder that can be caused or worsened by smoking.\nSmoking is a cause of erectile dysfunction in men. Pregnant women who smoke are at risk for a wide range of reproductive disorders that can harm babies and unborn children, including Sudden Infant Death Syndrome (SIDS), preterm delivery, low birth weight and birth defects like cleft lips and/or cleft palates.\nSmoking can damage blood vessels around the discs and joints of your back, causing chronic lower back pain. It is also the main cause of Buerger’s disease, an inflammation of the blood vessels in your arms and legs. This swelling creates blood clots in your arteries and veins, which can damage or destroy skin tissue and lead to infection.\n- Skin – Smoking weakens blood circulation, increasing the risk of skin infections. It also causes wrinkles and acne.\n- Hair – Smokers are more likely to go bald and grey than others.\n- Mouth – Tobacco yellows teeth as tar builds up in the tooth enamel. This also leads to bad breath.\nFor more information on the health effects of smoking and the dangers of tobacco, click here.", "label": "Yes"}
{"text": "GNC Mega Men® 2X MORE D-3 Dietary Supplement Clinically Studied Multivitamin with 1,600 IU of vitamin D-3 for colon health and immune support B-vitamins for energy support. Selenium, lycopene and vitamin E to support prostate health. Fights cell aging with advanced antioxidant blend. Frank J. Costa M.D., an acclaimed urological surgeon and men's health expert, is part of the GNC Medical Advisory Board. One of American's Top Physicians, Dr.Costa lectures nationally and international.\nWith 1,600 IU of vitamin D3 for colon health and immune support\nB vitamins for energy support\nSelenium, lycopene and vitamin E to support prostate health; Fights cell aging with advanced antioxidant blend", "label": "Yes"}
{"text": "Breathing liquid oxygen\nName: June Hagberg\nWould it be possible for humans to breathe liquid oxygen?\nLiquid oxygen is very cold, more than 200 degrees below zero on the\ncentigrade scale. At this temperature all of the desirable physical\nproperties of the lung would be nonfunctional. To get an idea of how\nthe flexibility of the lung would change, place a carnation in some liquid\nnitrogen or a super deep freeze. Your question is interesting though\nbecause it would be desirable to breath liquid instead of gas under\ncertain conditions. Special liquids are being designed to carry dissolved\ngaseous oxygen to the lung and to remove carbon dioxide. Even fish are\nbreathing dissolved oxygen, the water is much too warm for liquid oxygen.\nMichael B Lomonaco\nClick here to return to the Biology Archives\nUpdate: June 2012", "label": "Yes"}
{"text": "Accession Detail Results\n|Determination||Encelia farinosa var. farinosa |\nMore information: Jepson Online Interchange\n|Collector, number, date||Richard Noyes, L. Arnseth, 762, 1988-10-30|\n|Locality||Lake Mathews vicinity, Dry sandy margin of Cajalco road along southern boundary of Lake.|\n|Coordinates||33.82565 -117.43835 BerkeleyMapper [or without layers, here]|\n|Datum||WGS84; ER = 1.920 km|\n|Coordinate source||GoogleMaps via BerkeleyMapper|\n|Notes||Uncommon low shrub with bright yellow rays;|\n|Check for yellow flag|\nExplanations of the fields are available by clicking on the left-hand headings.\nInformation about the collector is available by clicking on the collector name.\nThe location can be mapped by clicking on \"BerkeleyMapper\".\nOther possibly pertinent records can be retrieved by clicking on \"Related searches\".\n|Copyright © 2018 Regents of the University of California — Updated 11 January 2019|", "label": "Yes"}
{"text": "Acute kidney injury (AKI) is associated with a high mortality in native kidneys, decreased allograft survival in transplants, and very high health care costs. Among the most common etiologies of AKI in both native and transplanted kidneys is ischemia-reperfusion injury (IRI). Despite advances in medical care, the mortality and morbidity associated with AKI after IRI remain high, with no specific therapy. A major unknown is the role of different T cell types in either causing/preventing tissue damage or improving/worsening repair. Detailed understanding of the roles of different T cell types holds great promise in both elucidating mechanisms underlying IRI and also in devising new strategies to ameliorate AKI. One such strategy is to shift the T cell balance in favor of protective T cell types and away from pathogenic ones. Therefore, it is important to study different T cell types residing and trafficking to the kidney and investigate their roles in the steady state and IR conditions. Our team has had a long-standing interest in studying immune cells in AKI using experimental animal models with translational potential. We recently discovered a unique population of CD4-CD8- double negative (DN) CD3+TCRab+ T cells that occupies a large niche of the ab T cell compartment in the normal mouse kidney and undergoes marked changes during AKI. However, their functions in the normal kidney and AKI pathogenesis remain relatively unknown. Based on strong preliminary data on DN cells, our overarching hypothesis is that kidney DN T cells play a major and unique role in regulating renal immune cell homeostasis in the steady state and after AKI.\nOur specific Aims are: 1) Investigate mechanisms and significance of steady state proliferation of kidney DN T cells. 2) Investigate immunoreactivity of DN T cells to IRI induced AKI. 3) Test the ability of DN T cells to prevent AKI and/or accelerate repair using gain and loss-of-function strategies. Establishing a functional role for this previously unappreciated cell type in the kidney will substantially advance our understanding of the kidney immunology and could lead to paradigm shifting scientific concepts.\nImmune cells are major players in ischemia reperfusion injury (IRI), a major problem in both native and transplanted kidneys. Our studies are expected to uncover the function of a novel T cell subset that resides in significant numbers in the normal kidney but whose function is poorly understood. The results can lead to new therapeutics to decrease injury and inflammation after kidney IRI.\n|Lee, Sul A; Cozzi, Martina; Bush, Errol L et al. (2018) Distant Organ Dysfunction in Acute Kidney Injury: A Review. Am J Kidney Dis 72:846-856|\n|Lee, Sul A; Noel, Sanjeev; Sadasivam, Mohanraj et al. (2018) Characterization of kidney CD45intCD11bintF4/80+MHCII+CX3CR1+Ly6C- \"\"intermediate mononuclear phagocytic cells\"\". PLoS One 13:e0198608|\n|Lee, Sul A; Noel, Sanjeev; Sadasivam, Mohanraj et al. (2017) Role of Immune Cells in Acute Kidney Injury and Repair. Nephron 137:282-286|\n|Martina, Maria N; Noel, Sanjeev; Saxena, Ankit et al. (2016) Double-Negative ?? T Cells Are Early Responders to AKI and Are Found in Human Kidney. J Am Soc Nephrol 27:1113-23|\n|Noel, Sanjeev; Desai, Niraj M; Hamad, Abdel Rahim A et al. (2016) Sex and the single transplanted kidney. J Clin Invest 126:1643-5|\n|Martina, Maria N; Noel, Sanjeev; Saxena, Ankit et al. (2015) Double negative (DN) ?? T cells: misperception and overdue recognition. Immunol Cell Biol 93:305-10|\n|Noel, Sanjeev; Martina, Maria N; Bandapalle, Samatha et al. (2015) T Lymphocyte-Specific Activation of Nrf2 Protects from AKI. J Am Soc Nephrol 26:2989-3000|\n|Dai, Hong; Rahman, Ayesha; Saxena, Ankit et al. (2015) Syndecan-1 identifies and controls the frequency of IL-17-producing naïve natural killer T (NKT17) cells in mice. Eur J Immunol 45:3045-51|\n|Noel, Sanjeev; Hamad, Abdel R A; Rabb, Hamid (2015) Reviving the promise of transcription factor Nrf2-based therapeutics for kidney diseases. Kidney Int 88:1217-1218|\n|Martina, M N; Noel, S; Bandapalle, S et al. (2014) T lymphocytes and acute kidney injury: update. Nephron Clin Pract 127:51-5|", "label": "Yes"}
{"text": "After establishing a pair bond\n, the male and female loaf together for a few days before they begin to build their nest.\n\"This is absolutely strange because there are very few rodents that pair bond\nfor life,\" says DeSalle.\nEven though excessive behavior in dementia is difficult to manage and can inhibit social activities, spouses are often still able to communicate with each other, verbally or by other means, and this ability seems to help preserve the pair bond\nThe scientists tested two predictions of the mate-guarding hypothesis in sleepy lizards: that females should play a passive role in maintaining the pair bond\n, and that males should become more attentive as the time of mating draws near.\nAlso included are interesting facts about these curious ocean birds: the first penguins appeared about 40 million years ago, penguins usually pair bond\n, chicks live together in groups called creches, and that an Emperor Penguin can weigh up to 90 pounds!\nAs the pair bond\nover the former's stories of car chases, they become alarmed when a growing number of dead bodies turn up.\nThe pair bond\nover their rubbrelationship situations and make that if they're both still single at 3they'll marry each other.\nThey're trying to understand whether humans are a naturally pair-bonded species and if this is the case, whether we pair bond\nfor life or for just as long as it takes to raise a child.\nMADONNA will \"cocoon\" her new daughter, Mercy, in Britain over the coming days while the pair bond\n, it has been reported.\nEASTENDERS PAT gets a job at the bookies and is shocked to find Jane running the cafe, but the pair bond\nand prove more than a match for Ian.\nInsel's research at NIMH into the complex social behaviors of animals demonstrated the importance of the neuropeptides oxytocin and vasopressin in maternal behavior, pair bond\nformation, and aggression.\nRoth excels as a weary assassin lumbered with the plodding son (O'Donnell) of a crime boss and the story truly engages as the mismatched pair bond\n. While it does get a tad preposterous, there is something sweet about the chemistry as it echoes 80s film The Hit, when Roth played the gauche youngster and John Hurt the hardened hit man.", "label": "Yes"}
{"text": "The Biology Department’s field station MLBS offers the full range of scientific, instructional, logistical, residential, and communications support expected at a modern biological field station. Research focuses on field-based ecology, evolution, behavior and physiology. Faculty and students in the Ecology and Evolution group use MLBS extensively. Located off-Grounds in Giles County Virginia (a three hour drive from Charlottesville), MLBS supports research programs from around the world, UVA Summer Session Courses, summer student internships (NSF REU-Site program), and a variety of other local and regional programs. UVA faculty and students spend exciting summers at the Station every year. Explore opportunities at MLBS.org.", "label": "Yes"}
{"text": "Advanced Lung Cancer – Treatment Options, Chemotherapy, Immunotherapy, Radiation Therapy, Clinical Trials\n## Understanding Advanced Lung Cancer\nAdvanced lung cancer, also known as stage 3 or stage 4 lung cancer, is a serious and often life-threatening condition that requires prompt and aggressive treatment. This type of cancer has spread beyond the lungs to other parts of the body, making it more challenging to treat.\n### Symptoms of Advanced Lung Cancer\nPatients with advanced lung cancer may experience a variety of symptoms, including:\n– Persistent cough\n– Chest pain\n– Shortness of breath\n– Unexplained weight loss\n– Difficulty swallowing\nIt is crucial for individuals experiencing these symptoms to seek medical attention promptly, as early detection and treatment can significantly improve outcomes.\n### Risk Factors for Advanced Lung Cancer\nSeveral risk factors can increase the likelihood of developing advanced lung cancer. These include:\n– Smoking: Cigarette smoking is the leading cause of lung cancer, and smokers are at a much higher risk of developing the disease.\n– Environmental exposure: Exposure to asbestos, radon gas, secondhand smoke, and other carcinogens can increase the risk of lung cancer.\n– Genetic predisposition: Some individuals may have a genetic predisposition to lung cancer, which can increase their risk of developing the disease.\n### Diagnosis and Staging of Advanced Lung Cancer\nDiagnosing advanced lung cancer typically involves a combination of imaging tests, such as CT scans and PET scans, as well as biopsies to confirm the presence of cancer cells. Once diagnosed, the cancer is staged to determine how far it has spread and the best course of treatment.\n### Prognosis and Survival Rates\nUnfortunately, the prognosis for advanced lung cancer is often poor, as the disease is typically diagnosed at a late stage when treatment options are limited. The overall 5-year survival rate for stage 3 lung cancer is around 27%, while for stage 4 lung cancer, the 5-year survival rate drops to just 4%.\n### Importance of Early Detection and Treatment\nEarly detection of lung cancer can significantly improve a patient’s chances of survival and enhance their quality of life. Regular screenings for individuals at high risk, such as heavy smokers or those with a family history of lung cancer, can help detect the disease at an early stage when treatment is most effective.\nBy understanding the symptoms, risk factors, diagnosis, and prognosis of advanced lung cancer, individuals can take proactive steps to protect their health and well-being. Seek medical advice if you experience any concerning symptoms or are at high risk for developing lung cancer.\nTreatment options for advanced lung cancer\nWhen it comes to treating advanced lung cancer, there are several options available depending on the stage of the disease and the overall health of the patient. It’s important to work closely with a healthcare team to determine the best course of treatment.\nSurgery is often a primary treatment for early-stage lung cancer, but it can also be used in some cases of advanced lung cancer. Surgical options may include:\n- Lobectomy: Removal of a lobe of the lung.\n- Pneumonectomy: Removal of an entire lung.\n- Sleeve resection: Removal of a portion of the bronchus.\nWhile surgery may not always be an option for advanced lung cancer, it can be considered in certain cases to remove tumors and relieve symptoms.\nChemotherapy is often used as a primary treatment for advanced lung cancer. It involves the use of powerful drugs to kill cancer cells or stop them from growing. Chemotherapy can be used alone or in combination with other treatments such as surgery or radiation therapy.\nAccording to the American Cancer Society, chemotherapy is a systemic treatment, meaning it affects the whole body and can reach cancer cells that may have spread beyond the lungs. Common chemotherapy drugs used for lung cancer include:\nChemotherapy can have side effects, including nausea, hair loss, and fatigue. However, advancements in supportive care have helped to manage these side effects and improve the quality of life for patients undergoing treatment.\n3. Immunotherapy and targeted therapy\nImmunotherapy and targeted therapy are newer treatment approaches for advanced lung cancer that target specific genetic mutations in cancer cells. These treatments are often used when chemotherapy is not effective or when the cancer has specific biomarkers.\nTargeted therapy drugs work by blocking specific proteins or pathways that are involved in the growth and spread of cancer cells, while immunotherapy harnesses the body’s immune system to attack cancer cells. Some targeted therapy drugs used for lung cancer include:\n- Erlotinib (Tarceva): Targets the EGFR gene mutation.\n- Crizotinib (Xalkori): Targets the ALK gene rearrangement.\nImmunotherapy drugs like pembrolizumab (Keytruda) and nivolumab (Opdivo) have shown promising results in treating advanced lung cancer and improving survival rates.\nBy understanding the various treatment options available for advanced lung cancer, patients and their healthcare providers can develop a personalized treatment plan that offers the best chance for a positive outcome.\nTreating Advanced Lung Cancer with Chemotherapy\nChemotherapy is a common and effective treatment option for patients with advanced lung cancer. It works by targeting rapidly dividing cancer cells in the body and preventing them from growing and dividing further.\nThere are several chemotherapy drugs used to treat advanced lung cancer, including:\n- Platinum-based drugs: such as cisplatin or carboplatin, are commonly used in combination with other drugs to treat lung cancer.\n- Paclitaxel (Taxol): a taxane drug that can be used alone or in combination with other chemotherapy drugs.\n- Gemcitabine (Gemzar): a drug that is often used in combination with other drugs to treat lung cancer.\nThese chemotherapy drugs can be administered intravenously or orally, depending on the specific treatment plan developed by the oncology team.\nAccording to the American Cancer Society, chemotherapy can be given as a primary treatment for advanced lung cancer or after surgery to reduce the risk of cancer recurrence.\nChemotherapy regimens for advanced lung cancer often involve cycles of treatment followed by a rest period to allow the body to recover from the side effects of the drugs. Common side effects of chemotherapy may include nausea, fatigue, hair loss, and decreased blood cell counts.\nClinical Trials for Chemotherapy in Lung Cancer\nClinical trials play a crucial role in advancing the field of lung cancer treatment. Researchers are constantly working to develop new chemotherapy drugs or improve existing ones to enhance their effectiveness and reduce side effects.\nAccording to the National Cancer Institute, participating in a clinical trial can give patients access to cutting-edge treatments that may not be available otherwise.\n|Side Effects (%)\nBased on the statistics above, the survival rates for advanced lung cancer patients receiving chemotherapy have shown a positive trend over the past few years, indicating the effectiveness of this treatment approach.\nFor more information on chemotherapy options for advanced lung cancer, consult with your oncologist or visit reputable sources such as the American Cancer Society or the National Cancer Institute.\nImmunotherapy and Targeted Therapy for Advanced Lung Cancer\nImmunotherapy and targeted therapy have revolutionized the treatment landscape for advanced lung cancer patients. These innovative approaches offer personalized and more effective treatments that target specific molecular markers or immune checkpoints. Let’s delve deeper into how these therapies are transforming the management of advanced lung cancer.\nImmunotherapy harnesses the power of the immune system to identify and destroy cancer cells. Checkpoint inhibitors, such as pembrolizumab (Keytruda) and nivolumab (Opdivo), work by blocking inhibitory checkpoints on immune cells, allowing them to recognize and attack cancer cells more effectively. These drugs have shown remarkable efficacy in a subset of advanced lung cancer patients, leading to improved survival outcomes.\nAccording to a study published in the Journal of Clinical Oncology, immunotherapy demonstrated a significant overall survival benefit in patients with advanced non-small cell lung cancer (NSCLC) compared to standard chemotherapy. The study reported a 5-year survival rate of 20% in patients treated with immunotherapy, highlighting the long-term benefits of these novel therapies.\nCombination therapies, such as combining checkpoint inhibitors with chemotherapy or other immunotherapy agents, are also being investigated to further enhance treatment outcomes for advanced lung cancer patients. Ongoing clinical trials are exploring the potential of immunotherapy in different settings, including as first-line or adjuvant therapy.\nTargeted therapy focuses on specific genetic mutations or alterations present in cancer cells, allowing for more precise and targeted treatment strategies. Drugs like osimertinib (Tagrisso) and crizotinib (Xalkori) target mutations such as EGFR and ALK, which are commonly found in lung cancer patients. By targeting these unique molecular aberrations, targeted therapies have shown promising results in improving response rates and progression-free survival in patients with advanced lung cancer.\nA clinical trial published in the New England Journal of Medicine demonstrated the efficacy of targeted therapy in patients with EGFR-mutant lung cancer, showing a significant improvement in progression-free survival compared to chemotherapy. These results underscore the importance of molecular testing to identify actionable mutations and guide treatment decisions in advanced lung cancer.\nHowever, it is essential to note that not all advanced lung cancer patients may have targetable mutations, limiting the applicability of targeted therapy in certain cases. Research efforts are underway to identify new targets and develop novel targeted agents to expand treatment options for a broader patient population.\nIn conclusion, immunotherapy and targeted therapy represent groundbreaking advancements in the management of advanced lung cancer, offering personalized and effective treatment options for patients. Continued research and clinical trials are key to further expanding our understanding of these therapies and optimizing their use in the treatment of advanced lung cancer.\nRadiation Therapy for Advanced Lung Cancer\nRadiation therapy is a common treatment option for advanced lung cancer that can be used alone or in combination with other treatments such as chemotherapy or surgery. It involves the use of high-energy radiation to target and destroy cancer cells.\nTypes of Radiation Therapy:\nThere are two main types of radiation therapy used for lung cancer:\n- External Beam Radiation: This type of radiation therapy delivers radiation from a machine outside the body directly to the tumor. It is a localized treatment that aims to shrink tumors and relieve symptoms.\n- Internal Radiation (Brachytherapy): In this type of radiation therapy, radioactive material is placed inside the body near the tumor. It allows for a higher dose of radiation to be delivered to the tumor while reducing exposure to surrounding healthy tissues.\nBenefits of Radiation Therapy:\nRadiation therapy can offer several benefits for patients with advanced lung cancer:\n- Shrinking tumors to reduce symptoms such as pain or breathing difficulties\n- Slowing the growth of cancer or stopping it from spreading\n- Improving quality of life by relieving symptoms and improving breathing\nPotential Side Effects:\nWhile radiation therapy can be effective in treating lung cancer, it can also cause side effects. Common side effects include fatigue, skin changes, nausea, and difficulty swallowing. These side effects are usually temporary and can be managed with medications or supportive care.\nResearch and Statistics:\n“According to the American Cancer Society, radiation therapy is often used in conjunction with other treatments for advanced lung cancer to improve outcomes and quality of life for patients.”\nResearch studies have shown that combining radiation therapy with chemotherapy or immunotherapy can lead to better outcomes for patients with advanced lung cancer. Clinical trials are also exploring new techniques and technologies to deliver radiation more precisely and effectively.\n|National Cancer Institute\n|Patients treated with concurrent chemotherapy and radiation had improved survival rates compared to radiation alone.\n|Journal of Clinical Oncology\n|Combining radiation therapy with targeted therapy showed promising results in shrinking tumors and improving progression-free survival.\nIt’s essential for patients with advanced lung cancer to discuss the benefits and potential side effects of radiation therapy with their healthcare team to make informed treatment decisions.\nFor more information on radiation therapy for lung cancer, you can visit the American Cancer Society website.\nIntegrative Therapies and Supportive Care for Advanced Lung Cancer Patients\nWhen dealing with advanced lung cancer, it is crucial to not only focus on conventional treatments but also consider integrative therapies and supportive care to improve the overall well-being and quality of life of patients. These complementary approaches can help manage symptoms, alleviate side effects, and promote a sense of well-being.\nIntegrative therapies encompass a wide range of practices that aim to complement traditional medical treatments. Some of the integrative therapies commonly used in advanced lung cancer care include:\n- Acupuncture: Acupuncture is an ancient Chinese practice that involves inserting thin needles into specific points on the body to help relieve pain and reduce stress.\n- Massage Therapy: Massage therapy can help ease muscle tension, reduce anxiety, and improve overall relaxation.\n- Yoga and Meditation: Yoga and meditation techniques can promote mindfulness, reduce stress, and improve mental well-being.\n- Dietary Supplements: Some patients may benefit from specific dietary supplements to support their overall health and well-being.\nSupportive care plays a crucial role in the treatment of advanced lung cancer by addressing the physical, emotional, and psychological needs of patients. Some aspects of supportive care include:\n- Palliative Care: Palliative care focuses on relieving symptoms, managing pain, and improving the quality of life for patients with advanced cancer.\n- Emotional Support: Providing emotional support through counseling, support groups, and therapy can help patients cope with the challenges of advanced lung cancer.\n- Nutritional Support: Proper nutrition is essential for patients undergoing treatment for advanced lung cancer. Nutritionists can help provide guidance on maintaining a healthy diet.\n- Physical Therapy: Physical therapy can help patients maintain mobility, improve strength, and manage pain related to lung cancer treatment.\nIt is essential for healthcare providers to consider the holistic needs of patients with advanced lung cancer and incorporate integrative therapies and supportive care into their treatment plans to improve the overall well-being and quality of life of patients.\n- National Center for Biotechnology Information – Integrative Therapies in Lung Cancer\n- National Cancer Institute – Supportive Care for Lung Cancer Patients\n7. Clinical Trials and Emerging Treatments for Advanced Lung Cancer\nClinical trials play a crucial role in advancing the treatment options for advanced lung cancer. These trials test new drugs, therapies, and treatment approaches to determine their effectiveness and safety in patients. Participating in a clinical trial can provide access to cutting-edge treatments that may not be available through standard care.\nOne promising area of research in advanced lung cancer is the development of targeted therapies. These therapies work by targeting specific genetic mutations or proteins that drive the growth of cancer cells. For example, drugs like osimertinib have shown significant benefits in patients with EGFR-mutated lung cancer, improving outcomes and quality of life.\nImmunotherapy is another innovative approach that harnesses the body’s immune system to fight cancer. Checkpoint inhibitors, such as pembrolizumab and nivolumab, have been approved for the treatment of advanced lung cancer and have shown promising results in clinical trials.\nCombination therapies, which involve using two or more treatments together, are also being explored in clinical trials for advanced lung cancer. These combinations may include chemotherapy, immunotherapy, targeted therapy, or other novel treatments.\nIt is essential for patients with advanced lung cancer to discuss the option of participating in a clinical trial with their healthcare team. Clinical trials are conducted at specialized research centers and hospitals, and information about ongoing trials can be found on reputable platforms like ClinicalTrials.gov.\nSome current clinical trials for advanced lung cancer include testing novel immunotherapy combinations, investigating new targeted therapies, and exploring innovative treatment approaches. Participating in a clinical trial can not only provide access to potentially life-saving treatments but also contribute to advancements in lung cancer research.\nSurveys and Statistical Data\nTo provide context for the importance of clinical trials in advancing lung cancer treatment, here are some key statistics:\n|Percentage of lung cancer patients enrolled in clinical trials\n|Survival rates for patients in clinical trials\n|Higher than those not in trials\nThese statistics underscore the significance of clinical trials in improving outcomes for patients with advanced lung cancer. Participating in a clinical trial may offer new hope and treatment options for individuals facing this challenging diagnosis.", "label": "Yes"}
{"text": "Sun, Oct 24, 2021\nPM2.5 refers to fine particles which penetrate deep into the body and fuel inflammation in the lungs and respiratory tract, leading to the risk of having cardiovascular and respiratory problems,...\nPaper Ad TariffWeb Ad Tariff\nCopyright @ 2021, Daily Thanthi. Powered by Vishwak", "label": "Yes"}
{"text": "Are organic foods healthier? Worth the extra expense?\nThe scientific debate has raged on for years. Now, a new report says yes’especially if you believe toxic chemicals are bad for your health.\nTwo years ago conventional media used a meta-analysis by Stanford University to cast doubt on the value of an organic diet. This despite the fact that the analysis’which looked at 240 studies comparing organically and conventionally grown food’found that organic foods are less contaminated with agricultural chemicals.\nIn an effort to further clarify the 2012 findings, a group of European scientists recently evaluated an even greater number of studies, 343 in all, published over the last several decades.\nHere’s what they found. Not only do organic foods have more nutrients, including cancer-fighting antioxidants, but they also contain far fewer pesticide residues. This is a no-brainer given that monoculture chemical and GMO farmers kill the soil with toxic chemicals and climate-destabilizing nitrate fertilizer’while organic farmers feed the soil with compost, nurturing the soil food web.\nBut the key nutritional difference between conventional and organics? Anywhere from 18 to 69 percent more antioxidants.", "label": "Yes"}
{"text": "This page may contain affiliate links that allow us to make a small commission from qualifying purchases (at no extra cost to yourself). We appreciate your support.\nTerrariums are a great addition to any garden or display inside your home. But what about outdoors? Can terrariums be kept outside? I have always wanted to create a nice outdoor display but was not sure how to keep a terrarium safe against the elements and what types of terrariums would thrive in certain climates. I decided to do some research and find out.\nCan terrariums be kept outside? Terrariums can be built to withstand outdoor elements and can survive in an outdoor setting. Open vessels planted with succulents and cacti work best. However, there are many factors that affect having an outdoor terrarium and knowing what they are might help you decide what is right for you.\nAlthough most people tend to avoid creating an outdoor terrarium due to the many complexities that arise from an outdoor setting, such as unpredictable weather conditions and other elements, understanding these challenges and how to overcome them will help you to decide if an outdoor terrarium is the right decision for you.\nClosed Vs Open Terrarium: Which is best for Outdoors?\nThere are two types of containers used for terrariums, closed and open. Open terrariums are best suited for the outdoors as they can be designed to tolerate outdoor elements more effectively. Succulents and Cacti are excellent plant choices that will flourish in most outdoor settings and are suitable for open terrariums.\nThere are a lot of differences between open and closed terrariums and both have different plant, lighting, and maintenance requirements. Below is a brief description describing the main differences between the two types.\nClosed terrariums are fully enclosed containers, usually made from glass with a removable lid used for maintenance. They are an ideal environment for plants that thrive in wet, humid conditions, with indirect light. Closed terrariums create their own water cycle through high degrees of humidity and moisture.\nThe moisture from the soil and plants evaporates into water vapor which is then condensed within the walls of the terrarium container. Precipitation then occurs when the water droplets from the condensation get too heavy and fall back to the plants and soil below. Due to this automated process, closed terrariums are mainly self-sufficient, requiring much less watering and maintenance. Due to the high degree of humidity and moist environment that closed terrarium plants need to survive, closed terrariums are not really suited for outdoors. It would be too hard to control the environment inside the terrarium when the terrarium is constantly subjected to the unpredictable outdoor elements and conditions.\nOpen terrariums do not require a lid and are not fully enclosed. They are best suited for plants that love the sun and do not require a moist environment. Open terrariums prefer circulating air and drier conditions which makes them great for outdoors. Succulents and Cacti are the best choice for an outdoor open terrarium, however, if storing your terrarium indoors, most houseplants can be used as well.\nOpen terrariums generally need to be watered more frequently than closed terrariums due to not having an internal water cycle through humidity buildup. However, always water with caution when dealing with desert succulents and cacti as excess accumulated water can cause your roots to rot and plants to drown. Succulents and cacti are used to dry conditions with minimal water so be sure to water sparingly once a week once the soil is completely dry.\nProtecting Your Terrarium from Direct Light\nOne of the biggest challenges for having an outdoor terrarium is managing sunlight. Most terrarium plants do not require direct sunlight/full sun, so it is very important that you make sure your plants do not overheat.\nTemperatures within terrariums can rise very quickly when placed in direct sunlight as terrarium glass magnifies the heat received from the sun. Direct light refers to rays of the sun directly touching the terrarium casing or plants. Most plants cannot handle this kind of heat which will cause your plants to burn. Warning signs that your plants may be getting too much light and starting to burn is if the leaves show signs of scorching or have brown spots.\nSo, if you are planning to have an outdoor terrarium that will be exposed to direct light, make sure to use plants that can tolerate high levels of light and heat. Even though desert succulents can thrive in the full sun, making sure to give them some time in light shade or indirect light during the harshest heat periods of the day will prevent burning and prolong life expectancy.\nTerrarium Plants that can Survive in Direct Light\nDesert succulents would be ideal plants to use for direct light. Here are a few suitable suggestions that are relatively low maintenance:\n- Agave Victoriae Reginae – Also known as the Queen Victoria Agave, this succulent originates from Mexico and loves the sun.\n- Living Stones – The most common species are Lithops and Conophytums. Although they may look like pebbles, these stones are well and truly alive and generally flower once a year. They do not require much water, usually five times a year is sufficient. Make sure to avoid watering in the winter to prevent bursting leaves.\n- Aloe vera – Also referred to as the “Medicine Plant”, the sap of the aloe plant has been used for centuries to treat wounds and burns (Healthline.com). It is a great plant to have on hand for those unexpected emergencies. Make sure to allow the soil to dry out between watering and that they receive plenty of light.\n- Paddle Plant – Also known as the Desert Cabbage, grows best in bright light. When placed in direct sunlight, the round leaves will get a red tinge. Make sure to give the terrarium a quarter turn every week to make sure that all sides of the leaves are getting equal exposure. These plants are suited best for larger, open terrariums or pots.\n- Tiger’s Jaw – Also known as Shark Jaw or by its botanical name of Faucarua Tigrina. This feisty succulent originates from South Africa and is a slow growing succulent which won’t outgrow your terrarium container for quite some time.\n- Hens and Chicks – Also known as the Houseleek plant. This drought-tolerant succulent produces clusters of rosettes. The parent rosettes are the “hens” and the smaller rosettes produced by the parent rosettes are their “chicks”. These plants require full sunlight to part shade and love to flower during the summer months.\nMost Terrarium Plants Love Indirect Light\nBright, indirect sunlight/partial sun is a better source of light for terrariums as most plants need at least some light to survive, yet it is not enough to overheat your plants if monitored correctly. Indirect light is ambient light or sunlight that has been filtered.\nAn example of indirect, ambient light is when sunshine is being filtered through clouds or other objects such as a sheer (outdoor curtain). The sunlight is still present, but the sun rays are not shining on the terrarium directly. This prevents the terrarium from overheating while allowing the plants to receive the sunlight that is required.\nOutdoor sheers are a great way to protect your patio or BBQ area from direct sunlight or glare. They allow terrariums to gain the light that they need without having to move them regularly to avoid direct sunlight. If your terrarium is in a garden or other outdoor area not suited for a sheer, a sunshade or canopy is a great alternative. This will be a lifesaver during the peak summer months in areas where you may be unable to put up a sheer. Make sure to find a sunshade that comes with ropes and is ready to use. These are my top picks for an outdoor sheer or canopy that are affordable and easy to set up.\nIt is best practice to not move your terrariums around to follow the sun or to avoid the direct light on a regular basis. As plants are naturally drawn to light, they tend to struggle if they must repeatedly orientate themselves. That is one of the benefits of using a sheer or canopy to assist in balancing the light, allowing you to keep your terrariums in one place.\nTerrarium Plants that Thrive in Indirect Light\nAlthough there are many terrarium plants that can thrive in indirect light, succulent plants suited for open terrariums would survive best in an outdoor setting. Below is a list of plant options that do best with indirect sunlight or partial shade.\n- Zebra Haworthia – Also known as the Zebra Cactus, this plant has visual similarities to the Aloe plant. They don’t like direct sunlight and do best when in partial shade or indirect light.\n- Burro’s Tail – This unique succulent requires little maintenance but comes with caution. The one thing to look out for is to be extremely careful when watering or moving the plant as the leaves are very fragile and will fall off easily. On the plus side, you can propagate new plants from each leaf.\n- String of Pearls – A beautiful, cascading succulent that can add that extra elegance to your terrarium. These plants would thrive best under a sheer or shaded area, with indirect light.\n- Crown Cactus – Also known as Rebutia Cacti, can tolerate a range of light conditions, from partial shade to full-sun. However, they tend to thrive best in bright, indirect light and cooler temperatures.\n- Gasteria – Commonly referred to as Ox Tongue, due to its long leaves and rough texture. Gasteria is a slow growing succulent that requires little water and prefers lightly shaded conditions.\n- Sand Rose – Known for their dual colored, rosette styled leaves showing olive green on one side and wine red on the other. This low maintenance succulent requires free drainage soil and minimal watering. The flowers they produce can grow up to 4 inches tall.\nLiving in a Hot Climate\nIf you happen to live in a hot climate there are a few important things to consider that will impact your choice of plants and degree of maintenance required to keep your terrarium healthy in the heat. Living in a hot climate with low humidity and dry air will provide less stress and lower maintenance when caring for your terrarium.\nThe American Horticultural Society has developed a similar ratings system to the USDA’s Hardiness Zone Map, with a Heat Zone Map. This map is helpful when trying to determine which plant types can tolerate a hotter climate. The summary table at the end of the article contains the hardiness and heat zone ratings for any plants suggested throughout the article.\nA hot climate with dry heat and low humidity levels is the ideal situation when dealing with trying to grow terrariums in hot climates. This is because succulents are often the best plants to grow in an outdoor terrarium, and they just love a dry, desert like environment. The one thing to look out for however, is that your plants are getting the water they need, without over watering. Watering once a week is usually sufficient, making sure that you wait until the soil is completely dry before watering.\nHumidity adds to the moisture in the soil and can lead to fungal infections and root rot. These symptoms can be deadly to your succulents and the overall health of your terrarium. However, if you happen to live in a hot climate, with high humidity levels, all hope is not lost. There are things that you can do to reduce the humidity so that having a terrarium is a possibility.\nMorning/evening dew is quite common in hot, humid environments and can inconveniently add to your humidity concerns and add unnecessary moisture to your soil. I would suggest storing your terrarium under a roof of some sort or using a canopy to assist with dew prevention.\nOne key thing that can greatly help to reduce the humidity within your terrarium is using more pumice.\nPumice works great when mixed with soil as it increases aeration and drainage and helps the soil to dry out faster. As pumice is an inorganic rock, it is long lasting and will not decompose or crumble away over time.\nAnother challenge with hot climates is light management. Making sure you understand the lighting requirements for your terrarium plants is vital, but even if they can handle long periods of direct sunlight, scorching can still occur, especially in extreme hot climates. Be aware of when the peak summer months occur which can often cause rising temperatures and heat waves. Consider using a sheer or canopy to prevent scorching or as an alternative, transition your terrarium to a partially shaded area in the weeks leading up to your summers peak season.\nPlants that Can Survive in a Hot Climate\nDon’t forget to keep an eye on your humidity levels and how your plants are doing. Even though the below list of succulents thrive in hot climates, if moisture levels are left uncontrolled, it could damage your plants.\n- Blue Chalksticks – This succulent acts as a great ground filler for your terrarium and can tolerate extreme heat. It is also fire resistant, although lets hope you never have to put it to the test!\n- Miniature Golden Barrel Cactus – This drought tolerant cacti can last for years if cared for correctly. Make sure to provided lots of sun and to water regularly making sure the soil is completely dry before watering.\n- Pachyphytum fittkaui – A relative of the Jade Plant, this succulent has blue-green, finger like leaves that display a pink to purple blush when basking in the sun. If temperatures drop below 45°F, be sure to move the terrarium inside as they do not handle frost or the cold well.\n- Paddle Plant – These sun-loving succulents love the dry heat and will struggle in temperatures below 50°F. The round, flat leaves can provide a variety of color to your terrarium and was the winner of the prestigious Award of Garden Merit of the British Royal Horticultural Society in the United Kingdom.\n- Aloe Vera – Aloe Vera can tolerate temperatures between 50°F to 85°F and love the full sun. Although this plant contains amazing medicinal properties if applied correctly, it can be poisonous to dogs and cats (ASPCA.org). So be sure to keep your terrarium out of reach from curious pets.\nLiving in a Cold Climate\nThere are many challenges to living in a cold climate that can create difficulties when creating an outdoor terrarium. Aside from choosing plants that can tolerate extreme winter conditions, understanding the environment challenges and how to manage them will allow you to have that winter terrarium that you have dreamed of!\nHardiness ratings are a system developed by the United States Department of Agriculture (USDA), to test the cold tolerance levels of plants. You can use our interactive map to find out your local hardiness zone which will help you to understand which plant types will be able to survive in your local climate. The summary table at the end of the article contains the hardiness and heat zone ratings for any plants suggested throughout the article.\nFrost and snow prevention may be quite difficult depending on how extreme your environment is but there are a couple of things you can do as long as you’re not living in a constant blizzard. Placing your terrarium in a covered area or using a portable, pop-up mini greenhouse could also work. They come in all shapes and sizes and often come with zipper windows and doors with clear plastic walls. This type of mini greenhouse can also help with prevention against strong winds, rain, and extreme temperature drops.\nHumidity is another common challenge within cold climates. As mentioned above, pumice is a great option to assist with moisture reduction in humid environments. As cold climates often have to deal with frost and snow, in addition to rain and excess moisture, it would be a good idea to get a soil moisture sensor to keep a closer eye on your terrarium’s humidity levels.\nThis 3-in-1 moisture sensor is a great choice as it also measures pH and light levels for an added bonus.\nAnother challenge, depending you where you may live, is lack of sunlight. There are many areas, where during winter months in particular, daylight is reduced to just a few hours. Other areas may experience extended periods of time that are overcast or where the clouds continuously block the sun for months on end. If you happen to live in this type of environment, then make sure to use plants or succulents that only require indirect light.\nIf you happen to have done all you can to keep your terrarium healthy and strong, but you notice one of your plants has early signs of root rot or is dying, make sure to remove those plants immediately. Dying plants can infect the other plants within your terrarium and so it is better to remove and replace them before your whole terrarium faces a similar fate.\nOutdoor Succulents that can Survive in Extreme Cold Weather\nMaking sure you pick the right plants is crucial to the survival and health of your outdoor terrarium, especially in a cold climate. Below is a list of suitable succulents that can tolerate extreme winter conditions:\n- Sempervivums – These rosette style succulents can tolerate extreme cold temperatures up to -30°F. The Sempervivum Red Lion and Mahogany are two great varieties that will provide a variety of colors for your terrarium.\n- Sedum Acre (Gold Moss) – This evergreen perennial has can tolerate a wide range of temperature changes from 25°F all the way down to -40°F. It is a mat-forming succulent with tangled stems covered with bright green leaves. During the summer months you can expect bright clusters of yellow flowers.\n- Dragon’s Blood Sedum – In the summer this low-maintenance sedum displays hot pink flowers and during winter months the green leaves turn a gorgeous wine red. The Dragon’s Blood Sedum thrives in cooler temperatures ranging from -40°F to -25°F.\n- Opuntias – Commonly known as the Prickly Pear Cactus, is the most common succulent that can be found across the US. These cold-hardy cacti can survive in -22°F weather and just love the sun. They are also drought tolerant, so can be a great addition to an outdoor terrarium. Just be careful of those spikes!\n- Ice plant Oscularia Deltoides – These plump little succulents are great winter plants and can tolerate mild frost and slightly freezing temperatures. Although they may not be able to handle the freezing temperatures of the other plants on this list, they can happily tolerate temperatures as low as 15 to 20°F.\nAdditional Challenges for an Outdoor Terrarium\nOther challenges that present themselves when trying to keep a terrarium outdoors is the unpredictability of the elements and environment. One vital consideration is to make sure that your terrarium is anchored properly so that it doesn’t get knocked over or blown away during strong winds. This can be more difficult for hanging terrariums, so make sure to be strategic when deciding on where your terrariums will be placed. The last thing that anyone wants is broken glass everywhere or a broken terrarium that you spent so much time on.\nConstant rain can also be an issue. The excess moisture in the air can damage your plants if not constantly monitored and maintained due to the increase in humidity. As the best terrarium plants suited for outdoors are succulents, constant moisture and humidity can create problems keeping your plants healthy. If you happen to live in a place that receives lots of rain, then make sure to choose your plants wisely and apply some of the methods discussed earlier for reducing and monitoring humidity.\nTable Summary of Plants\nChoosing the right plant type to have in your outdoor terrarium is key to making sure it can thrive within your specific type of climate. The USDA Plant Hardiness Zone Map below and the AHS Heat Zone Map are the standard by which gardeners and plant enthusiasts can determine which plants are most likely to thrive at a location. Under the map below, you can enter your location and understand your geographical hardiness zone.\nHere is a summary of information for the plants mentioned throughout this article for your convenience.\nAlthough maintaining an outdoor terrarium creates some additional complexities, that is no reason why you should shy away from one if that is your desire. Just make sure that you consider the following key takeaways:\n- Open Vessel containers are best for outdoor use\n- Succulents and Cacti are great plant choices for outdoors\n- Understand your plant’s sunlight exposure requirements\n- Direct Light/Full Sun vs Indirect Light/Partial Sun\n- Understand your climate and what plants are best suited for your location\n- Check USDA Hardiness Zone & AHS Heat Zone Ratings\n- Protect your terrarium against rain, strong winds, frost, and high humidity\nMeet Brad, the creator behind Vivarium Vibes, where his deep connection with nature and animals truly comes to life.", "label": "Yes"}
{"text": "Have you seen Dr. Vipul Patel before?\nBe the first to review!\nGet the facts about lung cancer, including how many people get it and what increases your risk for developing it.\nDr. Vipul Patel, MD is similar to these 3 Doctors near Phoenix, AZ.\nDr. Rajat Walia\nDr. Nariman Saddad\nDr. Jue Wang", "label": "Yes"}
{"text": "Researchers from Michigan, USA, determined the knowledge base and practice patterns of a nationwide cohort of primary care physicians (PCPs) regarding hepatitis C.\nA survey was developed to assess the knowledge of PCPs regarding risk factors for hepatitis C, management of hepatitis C patients, and attitude regarding testing for hepatitis C.\nThe survey was mailed to 4000 PCPs in the USA. A total of 1412 (39%) PCPs completed the survey.\nMore than 90% of PCPs correctly identified the most common risk factors for hepatitis C.\n|PCPs and hepatitis C trends:|\n90% correctly identified risk factors.\n59% asked all patients about risk factors.\n70% tested all with HCV risk factors.\n78% tested all with elevated HCV liver enzymes.\n25% did not know what treatment to recommend.\n|Journal of Viral Hepatitis|\nHowever, only 59% indicated they ask all patients about hepatitis C risk factors.\n70% reported they test all patients with hepatitis C risk factors and 78% test all patients with elevated liver enzymes for hepatitis C.\nMost (72%) PCPs would refer an HCV-positive patient with elevated aminotransferase. However, only 28% would refer an HCV-positive patient with normal aminotransferase to a specialist.\nA quarter of the PCPs did not know what treatment to recommend for hepatitis C patients.\nDr Shebab, of the University of Michigan Health System, Ann Arbor, said on behalf of fellow colleagues, \"Our data suggest that hepatitis C patients may be under-diagnosed and under-referred.\"\n\"Specific educational initiatives and practice guidelines for PCPs are needed to optimize the recognition of patients at risk for hepatitis C and to ensure appropriate testing and referral,\" it was concluded.", "label": "Yes"}
{"text": "Researchers at Peking University have applied gene editing to treat HIV. The CRISPR tool removed the CCR5 gene from the patient’s immune cells, which makes them vulnerable to the virus, Live Science reported.\nThere is no talk of a cure for a dangerous disease, but this is an important step towards effective gene therapy for HIV.\nThe experiment was conducted on an adult volunteer who developed leukemia against the background of HIV. In any case, the patient needed a bone marrow transplant, so the scientists took this opportunity and edited the stem cells from the donor sample before transplantation.\nCRISPR removed the CCR5 gene from cells, which synthesizes proteins located on the surface of certain immune cells. It is to these proteins that a viral particle attaches before it penetrates deeper into the cell. In individuals, the CCR5 gene contains a natural mutation that protects against HIV, but such a successful combination of genes is rare.\nThe surgery helped save the patient from leukemia. Tests showed that the edited stem cells took root and produced blood cells that remained in the body for 19 months. No unwanted side effects of gene editing have been detected.\nUnfortunately, the intervention did not save the patient from HIV. When he stopped taking antiretroviral drugs for a short while, the amount of viral particles in the body grew rapidly.\nThe reason, apparently, was that the CCR5 gene was not removed in all donor cells.\nHowever, the study was important evidence of the safety of CRISPR for HIV treatment, so the authors are optimistic. If you increase the effectiveness of gene editing, the technique will become the basis for new methods of dealing with this dangerous disease. True, they are not suitable for everyone, but only for patients who have already recommended bone marrow transplantation.", "label": "Yes"}
{"text": "Professor of Cell Biology\nHis research and teaching interests include T-cell development and signal transduction; he has recently been examining the effect of phytochemicals on cells of the immune system. He has also begun a student research program in fermentation science.\nHis other interests include astronomy, general aviation, skydiving, and zymurgy.\nThis course will provide an overview of the science and issues surrounding substance-related addictions and the processes and mechanisms that underlie addiction. We will address both the genetic and environmental underpinnings of addiction and introduce the epidemiology and developmental course of addiction. Students will work in teams of 4-5 to investigate an area of interest in the science of addiction. The groups will use the primary scientific and medical literature in an effort to understand the use, effectiveness and limitations of the particular treatments or approaches selected. Each team member will be responsible for some aspect of the research and will report back to the whole group. The groups will present their findings to the whole class. The students' goal is to assess the effectiveness of the various approaches by examining the available data carefully, explaining the methodologies employed to look at the treatment, and critically reading the authors' conclusions. Examples of past projects include: How do benzodiazapines affect episodic memory? How does cocaine affect the progression of HIV? Is sex addiction a real addiction? What alternatives to methadone are available in the treatment of pregnant women opioid addicts? Is caffeine an addictive drug? How effective is psilocybin for treating substance use disorder? Does alcohol affect men and women differently from a brain chemistry perspective? Each student will have the opportunity to work in three groups over the semester and to complete three projects and presentations. Students will also learn to find and read scientific research articles on topics of their choosing. They will write analytical critiques of these articles and will have numerous opportunities to revise these based on the instructors' comments. These critiques will form the basis of the final papers in which students explored a particular narrow topic on some aspect of addiction. The final compilation of the three critiques will be used in putting together their final papers. All students are also introduced to elementary aspects of data analysis and statistics. We also will have presentations by local treatment counselors as well as a video presentations from a local physician specializing in addictions treatment. A final portfolio of all work will be used to evaluate each student's progress.\nThis fermentation science course is designed to familiarize students with the current topics and procedures in brewing science. This upper-level course requires previous course and laboratory work in chemistry and microbiology. The course will focus on the study of the fundamental and applied sciences related to the use of microorganisms as production and processing agents. Specifically, we will examine the technological and biochemical aspects of the brewing process, including raw materials, malting, mashing, fermentation and maturation. In addition to lectures and discussion on the readings, the course will include extensive laboratory work. Students will work in small groups on a focused research project. Prerequisites: cell or molecular biology, and chemistry or microbiology.\nStudents in this course will learn about the biological function of selected human organs and systems through the study of actual medical cases. Not all human systems will be covered, but students will gain a good understanding of how diseases affect the body and how they are diagnosed. Working in small teams, students will develop diagnoses for medical cases through reviewing descriptions of patient histories, physical exams, and laboratory findings. A human biology text, medical texts on reserve, and Internet resources will help students track down information they need to solve these medical mysteries. Students will also learn to find and read scientific research articles on topics of their choosing and will learn to write analytical reviews of these articles. These reviews will form the basis of final papers in which students choose particular diseases or treatments to investigate in detail and present their findings to the class.\nThis fermentation science course is designed to familiarize students with the current topics and procedures in brewing science. This upper-level course requires previous course and laboratory work in chemistry and microbiology. The course will focus on the study of the fundamental and applied sciences related to the use of microorganisms as production and processing agents. Specifically, we will examine the technological and biochemical aspects of the brewing process, including raw materials, malting, mashing, fermentation and maturation. In addition to lectures and discussion on the readings, the course will include extensive laboratory work. Students will work in small groups on a focused research project. Prerequisites: cell or molecular biology, chemistry, or microbiology\nDreaming about winning a Nobel Prize in medicine? You might need this class exploring exciting topics in contemporary biomedical research.We will focus on rapidly advancing areas such as human microbiome, immunology targeted drug delivery, circadian rhythms, and more, with each of 6 Natural Science faculty members leading discussions on a cutting edge topic. Activities will include analysis of research papers, exploration of methodologies, problem solving, and an examination of the implications of this research for the future of medicine. Finally, students will have the opportunity to conduct independent inquiry into a topic of interest to them.\nThis course is designed as an introduction to the immune system. Our goal is to understand the basic elements of the immune system and the mechanisms by which these elements protect us from infectious agents, growth of tumors and other pathologic conditions. The overview design of the course will not preclude us from exploring a few areas in depth and students will also have an opportunity to dig deeply into an area of their choosing when writing papers and doing group presentations. We will stress the experimental basis of each concept we discuss. This will enable us to see how scientists analyze questions, design experiments and draw conclusions. This process will show us how fluid \"facts\" are and how they are being continuously modified. Primarily for this reason, we stress understanding the process rather than memorizing the \"fact\". The rapid pace of discovery makes the study of the immune system exciting and challenging. This course will provide you with enough background to pursue further study in this area. Prerequisites: physiology, cell biology or molecular biology.\nWe will explore the complex microbial interactions and succession seen in the production of some ales. This will be a research project-based course focused on questions of interest to brewers. The microbiology of many of the Belgian ales and some American dry hopped beers is quite complex and largely unexplored at the molecular level. The fermentation is natural and often involves mixed cultures of yeasts and bacteria. Some microorganisms may participate in parallel, while others act in a sequential manner with a changing dominant biota during the course of fermentation. Little work has been done to characterize these organisms at the molecular level. Even less is known about the environmental influences affecting the selection and displacement of the series of organisms that grow in these ales and the contribution of minor byproducts including flavor active esters and other bioactive molecules produced during fermentation. Previous course work in chemistry and microbiology or molecular biology is required. Prerequisite: NS 296, Zymurgy.", "label": "Yes"}
{"text": "This action might not be possible to undo. Are you sure you want to continue?\nAn Overview on Pectins\nB.R. Sharma, Naresh L., N.C. Dhuldhoya, S.U. Merchant and U.C. Merchant\nLucid Colloids Limited Jodhpur-342005, Rajasthan, India\nPectins have been utilised for their functionality in foods for many years. Ubiquitous in the conserves and preserves industries, development of pectins has centred on its use to impart texture in high sugar systems. Pectin has been widely studied and published but is difficult to characterise as a model system due to the heterogeneous nature of the polymer. Industrial use has mainly been focussed on tailoring the polymer to specific needs.\nBackbone structure Pectins are a family of complex polysaccharides that contain 1,4-linked α-Dgalactosyluronic residues. Three pectic polysaccharides, homogalacturonan, rhamnogalacturonan-I and substituted galacturonans, have been isolated from primary plant cell walls. Homogalacturonan (HG) is a linear chain of 1,4-linked α-D-galactosyluronic residues, in which some of the carboxyl groups are methyl esterified. They may also be Oacetylated at the C-2 and C-3 positions. Homogalacturonans have been isolated from sunflower heads and apple pectin but were obtained by extraction treatments likely to cleave covalent bonds so they may have been released from a heterogeneous pectic polysaccharide. Pectin is not a homopolysaccharide however and has rhamnopyranosyl residues inserted in the galactosyluronic backbone at 1 to 4% substitution. The other major feature of these rhamnogalacturonan-I (RG-I) chains are large substituted side chains. Between 20 and 80% of the rhamnopyranosyl residues are, depending on plant source and method of isolation, substituted at C-4 with neutral and acidic oligosaccharide side chains. The predominant side chains contain large linear and branched α-L-arabinofuranosyl and/or β-Dgalactopyranosyl residues and their relative proportion and chain lengths may differ depending on plant source. Other rarer side chains are also present and generally shorter.\nand less than that degree of methylation are called low methoxy (LM) pectins. RG-II is of interest as it occurs in relatively high amounts in wine and other fruit juices and it has been demonstrated that it binds heavy metals and has immunomodulating activities. The esterification of galacturonic acid residues with methanol or acetic acid is a very important structural characteristic of pectic substances.The final and much more minor component of the backbone is rhamnogalacturonan-II (RG-II).4-linked α-D-galactosyluronic residues like HG. acetic acid. phenolic acids and occasionally amide groups. Functional Groups Pectins also carry nonsugar subsituents. It is possible to separate essentially pure galacturonan fractions from other high molecular weight pectin fractions by degrading purified pectins specifically in the galacturonan backbone either chemically or enzymatically . This same principal applies to acetylation although the degree of acetylation . essentially methanol. This is not structurally related to RG-I since its backbone is composed of 1. The degree of methylation (DM) is defined as the percentage of carbonyl groups esterified with methanol. If more than 50% of the carboxyl groups are methylated the pectins are called high-methoxy pectins (HM). At approximately 30 glycosyl residues long it has a non-saccharide and an octasaccharide side chain attached to C-2 of some of the backbone residues and two structurally different disaccharides attached to C-3 of the backbone. It appears that there is an intramolecular distribution in which the neutral sugars are concentrated in blocks of more highly substituted rhamnogalacturonan regions ('hairy' regions) which are separated in the polymer by D-galactosyluronic-rich regions ('smooth' regions). These smooth regions can be up to 100 units in length.\n4 2.3 6. The overall polysaccharide is therefore ionic but with large neutral regions giving interesting functionalities. For commercially extracted pectins with tailored DM the distribution depends on the raw material and the extraction and de-esterification conditions.5 4.3 3.8 8. Commercial pectins can also be amidated.5 1 3.7 0.(DAc) can be larger than 100% as galacturonosyl residues can be acetylated with more than one group per monosaccharide.9 2.8 1.8 5 27.2 2. Overall the degree of substitution is known as the degree of esterification (DE).5 1. Methyl esterification is common in native pectins but acetylation is rarer in natural extracts. Table 1: Composition of a number of pectin sources Component Sugarbeet pulp Apple pomace Citrus peels Pea hulls (% w/w) 1.6 8 1.5 8 5.7 18.7 2 (% w/w) 1.2 14.4 2.2 2 5. For native apple pectins a random distribution of the metheyl esters groups over the galacturonan backbone was found.2 3. The amidation improves the gelling ability of low methoxy pectins in that they need less calcium to gel and are less prone to precipitate at high calcium levels.4 (% w/w) 1.6 1 1.2 45.3 1. Acetyl groups are generally present in the 'hairy' rhamnogalacturonan regions and only present in very low amount in homogalacturonan from apple and citrus.9 4.1 12.2 19.6 26 (% w/w) 0.1 17.5 1.3 21.9 25.7 Rhamnose and Fucose Arabinose Xylose Mannose Galactose Glc Galacturonic acid Methanol Ethanol Proteins Lignin Ash . They can be present in much higher amounts in homogalacturonan from sugarbeet and potato.\nThe presence of acetyl groups prevents gel formation with calcium ions but gives the pectin emulsion stabilising properties. The structure of such a junction zone is generally ascribed to the so called 'egg box' binding process. mainly governed by electrostatic interations. The gelation mechanism of pectins is mainly governed by their degree of esterification (DE). This results in a system resisting deformation and showing a stress-strain relationship for small deformation. For the low methoxyl pectins.Gelation of Pectins Low methoxy pectin (LM) LM pectins can gel in the presence of divalent cations. denoted LMP (DE < 50%). Such a gel is considered a 2-dimensional network of pectin molecules in which the solvent (water) with the co-solutes sugar and acid are immobilised. In these systems gelation is due to the formation of intermolecular junction zones between homogalacturonic smooth regions of different chains. gelation results from specific non-covalent ionic interactions between blocks of galacturonic acid residues of the pectin backbone and with divalent ions such as calcium. raw material and extraction conditions but molecular weight determination is a challenge because of the extra problems of heterogeneity and aggregation which can obscure data gathering. The build up of the 3-d network is based on the formation of junction zones in which there are chain associations stabilised by hydrogen bonding between undissociated carboxyl and secondary alcohol groups and by hydrophobic interaction between methyl esters. the distribution pattern of free and esterified carboxyl groups has an important effect on the strength of calcium binding. The gel forming ability of LM pectins increases with decreasing degree of methylation. LM pectins with a blockwise distribution of free carboxyl groups are very sensitive to low calcium levels. Initial strong association of two polymers into a dimer is followed by the formation of weak interdimer aggregation. . Molecular weight of pectins can be expected to vary with plant source. The affinity of pectin chains towards calcium is known to increase with decreasing degree of esterification or ionic strength. so-called low water activity gels or sugar-acid-pectin gels. High methoxy pectin (HM) HM pectins have the ability to form gels with sugar and acid. usually calcium. Besides the influence of the charge density of the polygalacturonate chain. and with increasing polymer concentration.\nGelling Properties and Applications Low methoxy pectin gels Calcium induced gelation is predominant in low methoxy pectin gels. Pectins can also be extracted using enzymes. improves the gelling ability of LM pectins and are less prone to precipitation by high calcium levels. Amidation.Sources and Extraction Pectin is found in most plants.5 to 6 hours are varied to give a material that has the desired gelling capacity and degree of methylation. Sodium deoxycholate (SDC) is used dilute to remove pigments and lipids and a treatment with 90% dimethyl sulphoxide (DMSO) will remove the bulk of the starch. Enzymatic degradation of the pectin is avoided by addition of a surfactant like sodium dodecyl sulphate (SDS). starches and nucleic acids. grapefruits) and apples. Grinding and washing with ethanol are used but this can lead to co-precipitation with intracellular proteins. lemons. Scientific studies have all extracted pectins using galacturonase enzymes. The separation of the viscous material from the swollen and partially disintegrated plant material remains a problem. The extraction of pectins can lead to large variations in the chemical structure of the final material. Another method by which this contamination may be avoided is by wet ball milling at low temperature. The extraction method may therefore be optimised for the type of pectin required.5 to 3. conversely. The disadvantage of alcoholic treatment could be the possibility of reinforcing hydrogen bonding between cell wall constituents and effecting the extraction of the pectins.0 and temperatures of 60-100 C for 0. Gel forming ability decreases with degree of methoxylation and some blockwise distributions of carboxyl groups are very sensitive to calcium presence. In order to extract unaltered pectins arabinase and galactanase could be used to avoid degradation. The effect of calcium is decreased by the acetylation of the pectin. but is most concentrated in citrus fruits (oranges. This results in short but branched segments. The advantage of alcohol treatment is that the resulting preparation is in a very suitable form for further modification to high methoxylated (HM) pectins using acid treatment or to low methoxy pectin (LM) by treatment with ammonia. be it modified or native. Gelation is due to the formation of intermolecular junction zones between the 'smooth' HG regions of separate polymers. Extraction conditions of pH 1. Pectins are industrially extracted from citrus peels and apple pomace by hot acidified water. is still debated. . Pectin obtained from citrus peels is referred to as citrus pectin. although known to be electrostatic to some extent. The nature of the interaction.\nand the chemical nature of the junction zones. Interactions of Pectin with other Hydrocolloids 1.2.1 . with the added evidence of low methoxy pectin gelation with alginate at very low pH.0 .1 Acid jams and jellies 2. Acetyl groups prevent gelation and the DM within the group of high methoxyl pectins determines the setting temperature of a gel. HM Pectin DM (%) Setting time (min) pH Application 3. High sugar conditions create low water activities which can be mimicked by other solutes with the same resulting gels. This finding. High dissolved sugar and acid conditions ensure that chain-chain interactions dominate over chain-solvent interactions.9 Acid to very acid and jellies Ultra Rapid Set 74-77 1-3 Rapid Set 71-74 3-7 Medium Set 66-69 15 .The modification of the hydrogen bonding nature of the polymer by the addition of amide or acetyl moieties indicates that the 'egg-box' mechanism of gelation may not apply for all situations of calcium induced low methoxy pectin gelation.8 . A pH above 4 also hinders the gel formation. The larger hydrophobic element in HM pectins allows for rapid arrest of the systems.3. Rupture strength depends on the number of junction zones per single long chain molecule whereas for rigidity the number of junction zones per unit gel volume plays a greater role.25 Slow Set 58-65 30-120 Many factors influence the conditions of gel formation and the gel strength achieved.6 .4 Jams with whole fruits 3. Under equal conditions gel strengths increase with the molecular weight of the pectin used.3 'Classical Jams' 2. High methoxy pectin gels Jams and preserves are of course the main use of industrially extracted pectins. Interactions between pectins and alginates Mixtures of pectins with other polysaccharides such as alginate has found that good gels are formed from high methoxy pectin and guluronic rich alginates. their chain length. This is reflected in the subdivision of HM pectins into rapid-set pectins of DM~77 to slow-set with DM~60. and any treatment depolymerising the pectin chains is reflected in weaker gels. indicates that the chains must be sufficiently charge .3. Most chain-chain interactions in these systems are not based on electrostatic interactions and so the other hydrophobic and hydrogen bonding effects exert most influence. The major role is played by the pectin molecules.3.\nresulting in higher production capacity. With increasing pectin share the texture of the gum articles becomes more elastic and brittle. are the so-called ”jelly beans“. and that esterification is required only to reduce electrostatic repulsion. With that the residence time in the mogul plant is shorter. Interactions of pectins with gelatin Gelatin is used almost exclusively in confectionery products. due to the number of interactions possible with pectins. The products are more stable at higher temperatures. The consumer expects a very special texture of this product and this is regulated with the pectin/starch ratio. 4. A further positive effect of adding pectin is the reduction of the setting time compared to a pure gelatin system. 3. there are many opportunities to explore different systems. the low-melting temperature of the products may prove to be a disadvantage. tough. Mixtures of proteins and polysaccharides are prone to incompatibility or undesirable complex formation. PolyL-lysine also serves to control network swelling. In some gum products even up to 15% gelatin may be necessary to obtain the desired firmness. Texture and chewing behaviour of the product can be regulated by the pectin/gelatin ratio. Interactions between pectins and proteins Understanding interactions between pectins and proteins is thought to be central to developing satisfactory food texture.neutralised before interaction can occur. For these products a dosage of 7-10% gelatin is required to reach a sufficient firmness. One such system sees LM pectin interacting with poly-L-lysine. When using gelatin alone. These clear. As with some hydrocolloids. strong gels crosslinked by physical bonds with the protein were obtained at pH's close to neutrality. thus increasing the storage stability of the confectionery products. Excess protein caused increased opacity and eventual network collapse. Compared with jelly products the texture is long and viscous. chain length of the protein was found to have an optimum value. Depending on the ratio of the two gelling agents either the pectin or the gelatin has a greater influence on the texture of the gels. which may correspond to the different regions of the pectin molecule. These mixed systems work well with cold setting conditions. This may be compensated by combining it with pectin. Alterations in consistency can be achieved by changing the pectin/starch ratio or by . 2. However. in which long. In pectins with a DE of 36%. with increasing gelatin share the products become more viscous. Interactions of pectins with starch One example of a product produced using a combination of pectin and starch. gum-like textures are desired. elastic gels had controlled increase in gel strength with added crosslinker up to an optimum. Here a part of the gelatin is replaced by a substantially smaller amount of pectin.\nPectin fibres exhibit higher hydration properties than other fibres and this property is exploited in its use as a structural component in foods. for example in bakery products. Pectin has the ability to associate ions due to a high content of negative charges and calcium .the choice of the pectin or starch used. The water binding is positively influenced by pectin thus leading to better preservation and longer storage stability. In these products a more viscous texture can be achieved by replacing the agar-agar partially or completely with pectin. 6. Gel formation of LM pectins with guar. When selecting the gelling agents. potato maltodextrin and gum arabic have shown there to be specific interactions between polysaccharide complexes. The fruits and vegetables which are especially rich in pectins have dietary fibre contents in the range of 1-2%. Complex formation between gum arabic and LM pectin (DM 31) was found to be enhanced when there was specific spatial compatibility between the HG areas of the pectin and the gum arabic fibrils. locust bean gum. oxidised starch. Pectin's adsorbent and bulk-forming properties have promoted its use in some multi-ingredient anti constipation and anti diarrhoeal preparations. This enhances the mouth-feel factor and hence provides a more distinctive flavor. Source of dietary fibre Pectin is sourced from plant cell walls and is analysed as a soluble and insoluble fraction as galacturonic acid after hydrolysis. Studies have shown that substitution of flour with citrus fibres. Nutritional Aspects of Pectins 1. In order to increase societal intake in fibre it is therefore preferable to add products concentrated in fibres. Combination of pectins with agar-agar Agar-agar is often used as the classic gelling agent in aerated confectionery products such as marshmallows. Branched hydrocolloids caused faster destabilisation of calcium induced LM pectin than linear polymers. These interactions were found to be non-ionic and were more likely a hydrophobic association and stabilisation which resulted in differing gel properties. Interactions with other polymers Interactions with other hydrocolloids has been studied in depth recently. Mineral binding Another functionality of dietary fibre is in mineral and ion absorption and exchange. apple flakes and concentrates in bakery and confectionery products had a positive sensory effect. the manufacturers should be consulted. interactions that are highly hydrophobic and non-ionic. 2. This takes into account the interactions of branched regions in pectins with other branched regions. 5.\nThe final products of fermentation of pectin are the short-chain fatty acids. It appears that the viscosity of pectin is related to its possible hypocholesterolemic activity. Pectin preparations with high viscosity appear to be more effective in lowering cholesterol than are pectin preparations with lower viscosity. The short-chain fatty acids that are not metabolised in the liver enter the systemic circulation and are distributed to the various tissues of the body. propionate and butyrate. In another study. High-viscosity pectin may interfere with the formation of micelles and/or lower the diffusion rate of bile acid and cholesterol-containing micelles through the bolus. giving 40 to 50 grams of pectin daily significantly lowered cholesterol levels in both normolipidemic and hyperlipidemic subjects. Pectin rich fibres can behave as weak cation exchange resins and are reversible depending on pH conditions. Studies on the metabolising of pectin chains has shown that many bacteria can degrade certain regions of the polymers. generally the HG regions. consequently diminishing the uptake of cholesterol and bile acids. Highviscosity pectin is thought to lower cholesterol levels by raising the excretion of fecal bile acids and neutral sterols. Subsequently. This use of a plentiful polysaccharide in maintaining and encouraging digestive flora is of advantage in assessing pectin uses in the future. It has been shown that non-methyl-esterified pectins were more rapidly fermented than methyl-esterified pectins. Prebiotic effect Following ingestion of pectin. Pectin substituents (homogalacturonans) are fermented in the colon with the formation of short chain fatty acids. 3. The short-chain fatty acids that escape colonic metabolism are transported via the portal circulation to the liver where they undergo metabolism. Pectins are therefore beginning to gain interest as prebiotics. Some fermentation of pectin takes place in the large intestine via the action of bacteria. Cholesterol regulation The mechanism of the possible hypocholesterolemic activity of pectin is not well understood. very little of it gets digested in the small intestine. Acetate appears to be the principal short-chain fatty acid to reach the systemic circulation from the liver. 4. In a small early study. a pectin-supplemented diet (without other dietary or lifestyle changes). as well as hydrogen and carbon dioxide. Numerous studies have demonstrated that pectin has favourable effects on lipids. administration of 15 grams of pectin daily for three weeks resulted in a mean 13% reduction in plasma cholesterol levels. There was no effect on plasma triglyceride concentrations. acetate.binding is an example of binding strength and specificity. significantly reduced plasma cholesterol in volunteers evaluated to be at medium to high risk for coronary heart disease due to .\n6% and LDLcholesterol 10. when administered orally to rats. The pectin was credited with decreasing plasma cholesterol 7. and thereby is thought to play an important role in the pathogenesis of cancer metastasis. Conclusion An understanding of pectin gelation in terms of the overall molecule as opposed solely to the associating areas may allow the expansion of pectin uses beyond their quite macroscopic behaviours to a more functionalised approach. galectins are secreted from cells via nonclassical secretory pathways. This was a double-blind. It is thought that galectins may play a role in human prostate cancer. Anti-cancer action Modified citrus pectin. galectin-3 mediates cell-cell adhesion and cell-matrix interaction via binding to its complementary glycoconjugates. the galactin family includes 10 members. inhibit the metastatic process. The inherent properties of pectins have not been fully explored and can. Galectin-3. . one of the members of the family. when researched. Some metastic events may involve cellular interactions that are mediated by cell surface components. which bind the branching carbohydrate molecules of glycoproteins and glycolipids on cell surfaces.8%. such as laminin and fibronectin. placebo-controlled trial.hypercholesterolemia. and in particular. Apparently. 5. Treatment continued for 16 weeks. It had no effect on the growth of the primary tumour. At present. Galectins are proteins that can bind to carbohydrates via carbohydrate recognition domains (CRDs). Injected modified citrus pectin was found to inhibit metastasis of melanoma cells in mice. The mechanism of these anticarcinogenic effects is not clear. Galectins comprise a family of galactoside-binding mammalian lectins. including galectins. On the cell surface. was found to inhibit spontaneous prostate carcinoma metastasis. resulting in agglutination or proliferation. human prostate cancer metastasis. Lectins themselves comprise a group of hemagglutinating proteins found in plant seeds. The galactose-containing carbohydrate side chains of modified citrus pectin may interfere with these cellular interactions by competing with the natural ligands of the galectins and by doing so. is thought to be involved in mitosis and proliferation. show some novel and timely applicabilities. among other things.\n1995. S.R. Marudova. 3.. 2001...K. 2004. O'Neill. 209-216.-F. 5. Ring. et al. G.. 25-31. Morris.A. In Advanced Dietary Fibre Technology. Ridley.. 55. 1... D..-C. 'Pectins: structure. Marcel Dekker Inc. 929-967.. Gibson. 339.. P. G. R. Ralet.. Blackwell Science. 57. 'Physicochemical studies in pectin/poly-L- lysine gelation' Carbohydrate Research. A. Mohnen. M. J.. MacDougall. In Food Polysaccharides and their applications. Thibault. M.R.. B. 2004. Richardson.. 2001. 'Effect of polymeric cosolutes on calcium pectinate gelation' 3 Parts. pg 287-340. Phytochemistry. 6.References and Recommended Reading 1. pg 369-378. biosynthesis and oligogalacturonide-related signalling'. A.. 2. E. Giannouli. 'Fibre and effects on probiotics (the prebiotic concept)' Clinical Nutrition Supplements. . M. 2004. Voragen. 4. Carbohydrate Polymers.", "label": "Yes"}
{"text": "Oregano is a herb. There are many varieties of oregano species. The oil extracted from wild oregano grown in the Mediterranean known as “Origanum Vulgare” has, for centuries. Numerous university studies have shown that Oil of Oregano is a highly potent purifier that provides many benefits for human health. Oregano oil naturally contains a range of nutrients such as Vitamins A, C and E. It also contains the minerals iron, magnesium, boron, manganese, zinc and calcium.\nOregano Oil is More Than Just An Antibiotic\nDozens of other studies confirm the fact that oregano oil can be used instead of harmful antibiotics for a number of health concerns. The rest of the research cited is supporting the fact that oregano is more than just an antibiotic. It’s the ultimate natural antibiotic!\nIt has two key compounds found in it are called carvacrol and thymol. Studies have shown that both of these compounds have significant effects on harmful micro-organisms that cause many illnesses in humans. It is known to be a potent antiviral, antibacterial, antifungal, and antiparasitic oil that can reduce pain and inflammation and effectively fight off infections.\nUsed to treat iron deficiency anemia, oral iron therapy is well-known to cause a series of gastrointestinal issues like nausea, diarrhea, constipation, heartburn and vomiting.\nOregano Oil is Powerful Antiseptic\nThymol, a chemical also found in oil of oregano, has been shown to be a powerful antifungal, antimicrobial, and antiviral agent.\nBecause Oregano oil is so powerful, it is wise to dilute it with olive oil or other suitable comestible oils for internal use. When using on skin, again dilute it with a carrier oil so that it does not sting the skin. Oregano oil can be used for skin conditions such as athletes foot. A mixture of four drops Oregano oil with apple cider vinegar is an ideal treatment for this condition. Other skin conditions such as psoriasis, eczema, and acne can be improved or eliminated with Oregano oil diluted with colloidal silver water or a carrier oil.\nOregano oil is effective in treating a myriad of conditions, some of which include, colds/flu, asthma, pneumonia, bronchitis, sinusitis, arthritis, animal bites, candida, ear infections, rashes and sore throat.", "label": "Yes"}
{"text": "The cells of the red microalga Porphyridium sp. (UTEX 637) are encapsulated in a cell wall of a negatively charged mucilaginous polysaccharide complex composed of 10 different sugars, sulfate, and proteins. In this work, we studied the proteins associated with the cell-wall polysaccharide. A number of noncovalently associated proteins were resolved by SDS-PAGE, but no covalently bound proteins were detected. The most prominent protein detected was a 66-kDa glycoprotein consisting of a polypeptide of approximately 58 kDa and a glycan moiety of approximately 8 kDa containing N-linked terminal mannose. In size-exclusion chromatography, the 66-kDa protein was coeluted with the polysaccharide and could be separated from the polysaccharide only after denaturation of the protein, indicating that the 66-kDa protein was tightly bound to the polysaccharide. Western blot analysis revealed that the 66-kDa protein was specific to Porphyridium sp. and P. cruentum, because it was not detected in the other species of red microalgae examined. Indirect immunofluorescence assay confirmed the location of the protein in the algal cell wall. The sequence of cDNA clone encoding the 66-kDa glycoprotein, detected in our in-house expressed sequence tag database of Porphyridium sp., revealed that this is a novel protein with no similarity to any protein in the public domain databases and our in-house expressed sequence tag database of the red microalga Rhodella reticulata. The 66-kDa protein bound polysaccharides from red algae but not from those of other origins tested. Possible roles of the 66-kDa protein in the biosynthesis of the polysaccharide are discussed.\n- Cell wall\n- Noncovalently bound protein\n- Polysaccharide- associated glycoprotein", "label": "Yes"}
{"text": "Miss Varrow, Science Department, informs us of the incredible news concerning space and St Augustine’s Priory:\n‘I am very excited to announce the Biology department of St Augustine’s Priory will be taking part in an experiment run by the UK space Agency. After Easter we will be receiving seeds that have been to space!\nTwo kilograms of rocket seeds were sent from Florida to the International Space Station as a part of British ESA astronaut Tim Peake’s six month Principia Mission. After spending six months on board, the seeds will be sent back to Earth and will land in the Pacific Ocean in spring 2016. They will then travel to the UK, where they will be packaged with other identical seeds that have stayed on Earth. Nobody will know which seeds have been to space and which have not! Our school, along with many other around the UK, will receive 2 packets of 100 seeds to grow and compare. The results gathered will input into a National online database to allow comparison with the results gathered from other schools.\nWe, as a school, are very fortunate to be able to take part in such an exciting experiment. It will give us a chance to learn how science in space contributes to our knowledge of life on Earth. It will also allow us to discover whether we can sustain human life in space through production of our own food. Not only will the girls be able to develop their statistical skills, but also will be able to explore the potential of future careers in STEM and Horticulture.’Categories: Junior Nursery Prep Senior Sixth Form Whole School", "label": "Yes"}
{"text": "The Genetics Society of America is hosting a one-of-a-kind conference that offers highly relevant organism specific content as well as broader topic-driven insights based on the fundamental unity of biology. The Allied Genetics Conference 2024 (TAGC 2024) connects scientists from multiple international biological research communities to share cutting-edge science, foster new collaborations, and strengthen existing relationships.\nThe conference will be held March 6–10, 2024 in National Harbor, MD (metro, Washington, DC).\nJoin us and other colleagues at TAGC 2024 to present your work to a diverse gathering of scientists, discover new findings in genetics and genomics, get inspired by keynote speakers, and advocate for science on Capitol Hill. You will also find opportunities for professional development, career advancement and networking. The unique programming aims to make TAGC 2024 a meeting that provides relevant tracks and content for all career stages, organism communities, research subjects, including members from academia, industry partners, and representatives of key scientific organizations and funding bodies. Everyone is welcome at TAGC 2024!\nSend in your abstracts by November 9, 2023 and register by December 13, 2023 for early discounts.\nWe hope to see you there!", "label": "Yes"}
{"text": "Ps 10-1049, Support for Strengthening and Expanding Comp HIV and AIDS Prev Pro\nPathfinder International, Inc., Watertown, MA, United States\nSee 7 grants from Sophia Ladha\nSee 60 grants from Pathfinder International, Inc.\nRecent in Grantomics:\nUniversity of Virginia\nvs. funders. Who wins?\nHow should you pick the next fundable research topic?\nRecently viewed grants:\nThe Role of Sorcs1 and Sortilin in Diabetes Susceptibility\nMechanisms of Early Recurrence in Intracranial Atherosclerotic Disease\nDrosophila, a new genetic model for renal disease and drug discovery\nDiscovery, Biology and Risk of Inherited Variants in Breast Cancer\nDoctoral Dissertation Research: Processing Prosody and Syntax in Turkish\nRecently added grants:\nFlow-stimulated endocytosis in the proximal tubule\nL-arginine as a therapy in severe asthma\nMechanisms of endothelial barrier phenotypes in sickle cell disease\nBicarbonate regulation of the pulmonary endothelial barrier\nUltrasound Shockwave Therapy for Post-Stenotic Microvascular Remodeling\nNational Institute of Health (NIH)\nGlobal HIV/AIDS Non-Research Cooperative Agreements (U2G)\nSpecial Emphasis Panel (ZPS1)\nPathfinder International, Inc.\nBe the first to comment on Sophia Ladha's grant\nShare this grant:", "label": "Yes"}
{"text": "Mossman’s Glen, Scott and Michael Fasano are among a handful of growers branching into peanuts as a fallow crop as they work to improve soil health and reduce fertiliser use while also developing a new stream of income. The trio harvested their first peanut crop in June and say the results have been encouraging. …Read more\nAbout: Elaine Seager\nRecent Posts by Elaine Seager\nCover crops have a range of benefits for soil health and nutrient management and since it's coming up to that time of year for ordering seeds, here's a rundown of the benefits of various species. Why implement cover cropping? Increases organic matter Legumes increase soil nitrogen Enhancing nitrogen recycling Reducing soil…Read more\nWhen Babinda cane grower Steven Bonso saw how soft the soil was on a Bundaberg farm during a field trip several years ago, he knew it was time to make some changes. “The penetrometer being used to measure soil compaction levels literally fell into the soil,’’ Mr Bonso said. “The farmer had been using the…Read more\nWTSIP's extension officers are developing their knowledge of pesticides in response to changes in the way pesticides are measured and assessed by the Queensland Government’s Paddock to Reef Monitoring and Modelling Program (P2R). The number of chemicals that are routinely measured is increasing - from 13 to 22 in the latest 2019 Wet Tropics Report…Read more\nRecent Comments by Elaine Seager\nNo comments by Elaine Seager yet.", "label": "Yes"}
{"text": "OMEGA 3 NATURE CAPSULES\nOmega-3 fatty acids belong to the group of polyunsaturated fatty acids and, unlike saturated fatty acids, cannot be produced by the body itself. They are vital for the organism and must therefore be taken in through food or dietary supplements. Omega 3 mainly consists of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). DHA contributes to the maintenance of normal brain function and normal eyesight. DHA and EPA also contribute to normal heart function. * Our capsules are high-dose and contain 750mg omega-3 fatty acids (of which 500mg EPA and 250mg DHA).\n|SIZE||120 OMEGA 3 NATURE CAPSULES|\nOVERVIEW OF OMEGA 3 NATURE CAPSULES\n- Omega-3s Can Fight Depression and Anxiety\n- Getting enough omega-3 is linked to a reduced risk of macular degeneration, one of the world’s leading causes of permanent eye damage and blindness hence can improve eye health\n- Omega-3s improve numerous heart disease risk\n- Omega-3 supplements can reduce the symptoms\n- of ADHD in children. They improve attention and reduce hyperactivity, impulsiveness and aggression\n- Omega-3 fatty acids can help fight several\n- autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, ulcerative colitis, Crohn’s disease, and psoriasis.\n- Omega-3 intake has been associated with a lower risk of asthma in both children and young adults\n- may improve bone strength and joint health, potentially reducing your risk of osteoporosis and arthritis.\n- Omega-3 fatty acids can reduce menstrual pain and may even be more effective than ibuprofen\n- Omega-3s can help keep your skin healthy, preventing premature aging and safeguarding against sun damage\nHOW TO USE OMEGA 3 NATURE CAPSULES\nTake 1 capsule daily with a glass of water.\nINGREDIENTS OF OMEGA 3 NATURE CAPSULES\nFish oil (from anchovies [50% EPA, 25% DHA]), softgel capsule (gelatin [bovine]), humectant (glycerin), water.\nThere are no inquiries yet.", "label": "Yes"}
{"text": "Monoamine neurotransmitters are stored in both synaptic vesicles (SVs), which are required for release at the synapse, and large dense-core vesicles (LDCVs), which mediate extrasynaptic release. The contributions of each type of vesicular release to specific behaviors are not known. To address this issue, we generated mutations in the C-terminal trafficking domain of the Drosophila vesicular monoamine transporter (DVMAT), which is required for the vesicular storage of monoamines in both SVs and LDCVs. Deletion of the terminal 23 aa (DVMAT-Δ3) reduced the rate of endocytosis and localization of DVMAT to SVs, but supported localization to LDCVs. An alanine substitution mutation in a tyrosine-based motif (DVMAT-Y600A) also reduced sorting to SVs and showed an endocytic deficit specific to aminergic nerve terminals. Redistribution of DVMAT-Y600A from SV to LDCV fractions was also enhanced in aminergic neurons. To determine how these changes might affect behavior, we expressed DVMAT-Δ3 and DVMAT-Y600A in a dVMAT null genetic background that lacks endogenous dVMAT activity. When expressed ubiquitously, DVMAT-Δ3 showed a specific deficit in female fertility, whereas DVMAT-Y600A rescued behavior similarly to DVMAT-wt. In contrast, when expressed more specifically in octopaminergic neurons, both DVMAT-Δ3 and DVMAT-Y600A failed to rescue female fertility, and DVMAT-Y600A showed deficits in larval locomotion. DVMAT-Y600A also showed more severe dominant effects than either DVMAT-wt or DVMAT-Δ3. We propose that these behavioral deficits result from the redistribution of DVMAT from SVs to LDCVs. By extension, our data suggest that the balance of amine release from SVs versus that from LDCVs is critical for the function of some aminergic circuits.\nKeywords: LDCV; dopamine; octopamine; serotonin; synaptic; vmat.\nCopyright © 2014 the authors 0270-6474/14/346924-14$15.00/0.", "label": "Yes"}
{"text": "6 edition of Stem Cell Now found in the catalog.\nNovember 8, 2005\nby Pi Press\nWritten in English\n|The Physical Object|\n|Number of Pages||256|\nOnline Now. Article. High-Resolution Dissection of Chemical Reprogramming from Mouse Embryonic Fibroblasts into Fibrocartilaginous Cells. Chen et al. Learn about stem cell research and its potential to impact human health. Policy and Advocacy. Advocating worldwide for ethical stem cell research and clinical translation. Mar 07, · Maybe you’ve heard recently in the news how Mel Gibbson took his dad to stem cell therapy. His dad got injected with stem cells at 92 and now he's still kicking it at years of age. Want to know how to stay youthful and live longer? This article will tell you how to .\nAug 18, · If you want to learn more about these topics, read my mini-book on how to pick a reputable stem cell clinic for your knees: How Long Does Stem Cell Therapy Last for Knees? Right now, only the research on bone marrow stem cells is robust enough to reliably answer the question of how long does stem cell therapy last for knees. Apr 30, · New Stem Cell Book Highlights The Patient Perspective. the book is part of the non-profit Stem for Life Foundation's ongoing efforts to highlight and now it was time to try the procedure.\nA comprehensive textbook covering major aspects of stem cell research and therapeutic applications. The Stem Cell Institute of Hawaii is dedicated to an ethical and honest approach to emerging stem cell technologies and research. Now serving Kona, Maui, Oahu and Kauai. Book an Appointment. Write us. Book A Free Consultation.\nRequisitioning of ships in time of national emergency\nAll sizes of noises.\nWhatever happened to job security?\nFourth supplemental appropriation bill for 1951.\nflying, fighting weathermen of Patrol Wing Four, 1941-1945, U.S. Navy\nstory of prehistoric animals.\nBasic contract law (Tools for Your Business Workbelt--cover)\nJawaharlal Nehru and the disadvantaged\nWisdom in education\nJun 30, · Stem Cell Now is essential reading for anyone who wants to build an informed opinion on stem cell research. Inspire a love of reading with Prime Book Box for Kids Discover delightful children's books with Prime Book Box, a subscription that delivers new books every 1, 2, or 3 months — new customers receive 15% off your first box.\nCited by: 4. This is a fascinating book on important scientific, medical and consumer issues.” CHOICE Stem Cells: An Insider's Guide is an exciting new book that takes readers inside the world of stem cells guided by international stem cell expert, Dr.\nPaul Knoepfler. Stem cells are catalyzing a revolution in medicine. The book also tackles the exciting Cited by: 1.\nDec 08, · While many believe stem cell research holds the key to curing a wide range of ailments, others see this research as opening a Pandora's box that will devalue human ktexcleaning.com Stem Cell Now, Christopher Scott--executive director of Stanford University's Stem Cells and Society Program--lays out the scientific and ethical issues surrounding this national dilemma/5.\nImmunological considerations for cell therapy using human embryonic stem cell derivatives; Doug Melton talks Stem Cell Now book StemBook about diabetes, stem cells, and making beta cells.\nAllan Spradling talks with StemBook about polyploidy, evolution, and the state of funding for basic science. We offer advanced aesthetic procedures used by celebrities, state-of-art hormone optimization, sexual wellness for both men and women, weight loss protocols that work and now stem cell therapy.\nBook a consult today to find out how our Anti-Aging Program can change your life. Live SANTÉ. A stem cell is a cell that, when it divides, can produce a copy of itself as well as a differentiated cell progeny. This self-renewal capacity is essential to the function of adult stem cells, such Stem Cell Now book hematopoietic stem cells and spermatogonial stem cells – to continually renew tissues that turn over rapidly in the adult.\nA higher rate of stem cell circulation goes beyond the improvement of external signs of aging. Anti aging treatment thought stem cell therapy permeates deeply and throughout the body. Book you consultation now and see what treatments can give you benefits for a better tomorrow.\nStem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is a form of stem cell therapy that has been used for many years without controversy.\nAdvantages. Stem cell treatments may lower symptoms of the disease or condition that is being ktexcleaning.com: Neil H. Riordan, PA, PhD Neil Riordan, PA, PhD is an accomplished scientist, developer of regenerative medicine therapeutics, author of more than 70 peer-reviewed publications, and holder of more than 40 patents and patent applications.\nRiordan discovered and developed two novel stem cell types that cleared FDA requirements for use in the United States. Looking for a stem cell book that is clear and tells the real story of stem cells.\nTake a look at my book, Stem Cells: An Insider’s Guide. It is a broad look at the exciting stem cell field, warts and all. An Introduction to Stem Cell Biology Michael L. Shelanski, MD,PhD Professor of Pathology and Cell Biology The stem cell is the ancestor at the top of the family adult cell becomes pluripotent Now In future Martin F.\nPera. Do We Have the Ability to Repair Ourselves. Our new book: The Stem Cell Revolution is now available. Purchase Signed Copy Download Free eBook.\nWelcome to the Cell Surgical Network. Welcome to the Cell Surgical Network®. The affiliates of the Cell Surgical Network® (CSN) are devoted to advancing access and quality care in the area of adult stem cell regenerative medicine in order to.\nStem cells: What they are and what they do. Stem cells and derived products offer great promise for new medical treatments. Learn about stem cell types, current and possible uses, ethical issues, and the state of research and practice.\nAug 01, · In a book of this scope, there are inevitably a few mistakes, but it is generally thorough and accurate.\nResearch with stem cells offers one of the most important opportunities to understand and develop new treatments for human disease. Stem Cell Now provides a good introduction to the subject.\"Cited by: 4. Publisher Summary. One common strategy of embryo development is the use of the stem cell to help generate and maintain a given tissue or organ.\nA stem cell is a cell that, when it divides, can produce a copy of itself, as well as a differentiated cell progeny. Stem cell, an undifferentiated cell that can divide to produce some offspring cells that continue as stem cells and some cells that are destined to differentiate (become specialized).\nStem cells are an ongoing source of the differentiated cells that make up the tissues and organs of animals and plants. Stem Cell Therapy for Autoimmune Diseases What is Autoimmune Diseases. Autoimmune diseases are conditions in which the patient’s immune system generates cellular and antibody responses to substances and tissues normally present in the body.\nThis might be restricted to one organ or involve a particular tissue in different places. US STEMOLOGY is a leader in stem cell technology and combines it with a holistic approach to support your stem cell treatment with nutrition, hormones, microbiome, and addressing inflammatory issues.\nStem cells are like seeds and your body is the dirt. When you’re trying to grow things, dirt matters!. Types of Stem Cell Transplants. In a stem cell transplant, you receive healthy blood-forming stem cells through a needle in your vein.\nOnce they enter your bloodstream, the stem cells travel to the bone marrow, where they take the place of the cells that were destroyed by ktexcleaning.com blood-forming stem cells that are used in transplants can come from the bone marrow, bloodstream, or.\nIn Richmond, Virginia, Dr. Goradia with G2 offer stem cell injections for less than half the cost. Insurance plans don’t cover the cost of stem cell injections, but patients can use FSA funds for full payment. Due to the cost of the supplies needed for these injections, full payment is required at the time of surgery.\nThis book tells the story of the breakthroughs in working with embryonic stem cells and how this may help us grow new tissues to repair injuries. Scientists and medical researchers hope to induce stem cells to become nerve and muscle cells, which will then replace nonfunctioning cells and .This book provides up-to-date reviews on a wide variety of stem cell systems by world experts.\nChapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest.Stem Cell Therapy is the future of medicine and the future is now.\nStem cell therapy signals to the body to achieve cellular regeneration. There are many applications for stem cells and here are a few.", "label": "Yes"}
{"text": "Unlocking the Potential of Your Genetic Variant: Understanding PEMT\nCongratulations on completing the Genetics Compatibility Quiz! If you've arrived here, it's likely that your genetic variant is PEMT, which could be influencing your health. If you're here to learn more without the PEMT variant, you're in for some valuable knowledge too!\nPEMT Genetic Variant Explained:\nThe PEMT genetic variant plays a vital role in how your body produces phosphatidylcholine, a crucial element for maintaining healthy cell membranes, muscles, brain function, and liver health.\nIndividuals with the PEMT variant often experience the following tendencies:\nFatty Foods Sensitivity: Fatty foods may feel heavy and irritating, leading you to prefer a vegetable-rich diet.\nHistory of Gut and Liver Issues: You might have had past or current challenges with your gallbladder, gut, or liver health.\nPros of PEMT Variant:\nThe PEMT variant may offer some advantages, particularly in the area of methylation support.\nCons of PEMT Variant:\nHowever, it's essential to be aware of potential challenges associated with this variant, including problems with the gallbladder, small intestine bacterial overgrowth (SIBO), pregnancy-related issues, muscle pain, and cell membrane weakness.\nRecommendations for Optimal Health:\nTo support your overall well-being, consider the following supplement and lifestyle recommendations:\nNatural Athlete’s Calm and Focused\nNatural Athlete’s Anti Inflam\nMethylated B vitamins: B9 (folate), B12 (cobalamin), B2 (riboflavin)\nNatural Athlete’s Omega-3\nNatural Athlete’s Probiotics\nNatural Athlete’s Active Tissue\nEmbrace Green Leafy Veggies: Increase your intake of nutrient-rich green leafy vegetables to boost your health.\nAdequate Protein Intake: Consume enough protein daily by multiplying your weight by 0.36 for the recommended grams.\nStay Hydrated: Drink filtered water daily, aiming for half your body weight in ounces.\nReduce Stress: Incorporate stress-reducing activities such as meditation, saunas, music, art, exercise, or massage. Natural Athlete’s Stress & Anxiety can be a helpful supplement too.\nPrioritize Quality Sleep: Aim for 7.5-9 hours of quality sleep per night. Natural Athlete’s Rest and Relax can assist with this.\nPractice Mindful Eating: Learn to stop eating when you're 80-90% full to avoid overeating.\nLimit Refined Carbs and Alcohol: Reduce consumption of refined carbs like bread, pasta, and pastries, and avoid alcohol.\nHealthy Cooking Oils: Cook with avocado, safflower, and Ghee oils, and avoid hydrogenated vegetable oils.\nUnderstanding your genetic variant, whether PEMT or not, can empower you to make informed choices for your health. By following these recommendations and nurturing a mindful lifestyle, you can optimize your well-being and unlock the potential of your unique genetic makeup. Remember, always consult with a healthcare professional before making significant changes to your diet or lifestyle. Embrace these suggestions, and you'll be on the path to a healthier, more balanced life!", "label": "Yes"}
{"text": "Cornus mas Variegata | Cornelian Cherry\n- Genus: Cornus\n- Species: mas\n- Cultivar: Variegata\n- Eventual Height: 250\n- Eventual Spread: 250\n- Position: full sun, partial shade, north, south, east, west\n- Evergreen or Deciduous: Deciduous\n- Soil Drainage moist but well drained\n- Soil PH: acid, neutral\n- Exposure: exposed, sheltered\n- Hardiness: (H4) Hardy\n- Awards: RHS Award of Garden Merit\nFebruary-flowering, the Cornelian Cherry is a densely branched deciduous shrub when in full flower will lift the spirits on a dull winters day. A compact shrub bearing clusters of bright yellow flowers in early spring, followed by large, red edible fruit in autumn. The colourful, cream edged, grey-green leaves, turning red in autumn, make the Cornus mas Variegata an excellent ornamental tree for the small gardens and woodland areas. The fruit of the Cornelian cherry tastes of a cranberry and cherry mix.\nWrite an online review and share your thoughts with other shoppers!", "label": "Yes"}
{"text": "Lung Cancer Awareness: Prevention is the ONLY cure\nA Message from a Coloradan and Victim of Radon-Related Lung Cancer-Johanna’s Story\nA Message from a Victim of Radon-Related Lung Cancer-Rebecca’s Story\nA Message from a Victim of Radon-Related Lung Cancer-Eddie’s Story\nA Message from a Victim of Radon-Related Lung Cancer-Elizabeth’s Story\nThe Dr Oz Show-The #1 Cancer Risk at Home-Part One\nThe Dr Oz Show-The #1 Cancer Risk at Home-Part Two\nHave you Heard of Radon?\nRadon the Invisible Killer\nTODAY SHOW Investigative Reports about “Radon In Schools”\nRadon Gas Caused Utah Woman’s Lung Cancer\nACE Radon on Haystack Colorado CBS4\nLiving in the Red Zone: Good for Football, Not Good in Terms of Radon\nYoung Women, Never-Smokers, and Lung Cancer\nRadon gas suspected in Prince George, B.C., family tragedy\nThe Dangers of Radon\nDo Granite Countertops Emit Radon? (And Other Radon FAQs)\nFamilies Struggle with Radon in Military Housing\nRadon and Lung Cancer\nRadon Tests Surge Since Law Passed\nMedicare Issues Final Decision to Cover Lung Cancer Screening\nColorado Officials Try To Raise Radon Risk Awareness\nRadon’s Link to Lung Cancer\nColoradans Encouraged to Test Their Homes for Radon\nRadon’s link to Asthma\nReduce Your Risk of Lung Cancer\nRadon-Worse than Ebola!\n10 Scary Things to Avoid in Your Home\nShould MY Home be Tested for Radon?\nJanuary is National Radon Action Month\nThe Radon Threat Is Still With Us\nRadon in Utah homes can lead to lung cancer diagnosis\n1 in 3 Utah homes has cancer-causing radon at potentially harmful levels\nHouse OKs bill to regulate radon testers\nCT Scans Can Reduce Lung Cancer Deaths, Study Finds\nNation Cooking on Radioactive Countertops\nWhat’s Lurking in Your Countertop?\nRadon in the Home Can Cause Lung Cancer\nFast Facts on Lung Cancer\nRadon/Radiation in Granite Countertops\nThere are basically two concerns regarding radon and radiation in Granite Countertops. One is the airborne radon contributed by the “emanation” of radon from the granite slabs. The second issue is the radiation released by the radon in the granite that contributes to the day to day millirems that each person on earth is exposed to from both man-made and natural sources.\nAirborne radon is the leading cause of lung cancer in non-smokers, and the second leading cause of lung cancer in smokers. The main source for radon is from the natural deterioration of uranium in the soil. In Colorado, approximately 60% of homes will test over the 4 pCi/l action level set by the Environmental Protection Agency, and most homes have not been tested. Based on ACE’s 21 years of experience in the industry it is rare that emanation from granite countertops contributes enough airborne radon to pose a serious health risk. Even when the concentration of radon in the granite is high the equivalent airborne radon levels are usually not detected in a typical airborne radon test. Therefore, if the residence has not been tested for radon sourced from the soil, ACE recommends this be the best first step in mitigating any health risk due to radon.\nThe health risk of radiation or air borne radon from granite countertops is best assessed by the amount of time spent near the countertops, the “emanation level” of the radon in the countertops, and an airborne radon level in the space where the granite countertops reside. If the residence has been tested for radon levels from the soil and the results were less than 4 pCi/l or if the residence has a working radon mitigation system, ACE recommends the next step to assessing the health risk from the granite countertop is a three-fold testing process. It is important to note the all the testing should be done simultaneously over the same 48 hour period.\nTest Kit #1: Perform an Emanation test on the granite countertop surface. This test can be performed by a NEHA certified radon-testing firm, (a list of measurement providers can be found @ www.radongas.org), or a do-it-yourself kit can be deployed.\nIf a do-it-yourself kit is desired then ACE would recommend a flat envelope test kit by a company called Air Chek. These kits can be purchased on the website for $14.95 @ www.radon.com and due to the size and shape work well for emanation diagnostics. Follow the directions that come with the kit, except do not hang it. The test kit should be placed flat on the surface of the granite top, covered in a minimum 6-mil plastic and taped “air tight” to the surface and left for a minimum of 48 hours. After 48 hours the test kit can be mailed to the lab and the test results provided within 3 to 5 business days.\nTest Kit #2: Perform an airborne test in the kitchen, hanging the test kit according to the instructions around “shoulder height”. It would be wise not to cook or run the dishwasher during the testing period since kitchen grease and moisture can skew the radon test results. After the same 48 hours the test kit can be mailed to the lab and the test results provided within 3 to 5 business days.\nTest Kit # 3: Perform another airborne test in the home on the same level as the granite countertop of area of concern, and in the area away from the granite countertop such as a bedroom or living area is ideal (not a bathroom). After the same 48 hours the test kit can be mailed to the lab and the test results provided within 3 to 5 business days.\nInterpreting Results: Test Kit # 1 will provide an indication of the radon concentration in the granite in pCi/l before the radon gas is diluted in the space. This will give an indication of the concentration of radon at the surface of the countertops. A high radon concentration (pCi/l) is indicative of a high radiation level (millirems) that may contribute to your decision to change the countertop material. To measure the actual radiation level emitted by the countertops a Geiger counter would be the recommended method of measurement.\nTest Kit # 2 will provide the airborne level in the proximity of the granite countertop. Test Kit # 3 will provide the airborne level in the residence that is not in the proximity of the granite countertop. If the difference in the radon level between Test Kit # 2 and Test Kit # 3 is similar, the airborne risk of the radon from the granite countertops is not likely a health issue. If the difference in the radon level is 2 pCi/l or more another countertop material should be considered. According to the NACI, an exposure of 2 pCi/l is the equivalent risk of getting lung cancer as someone who smokes.\nIn summary, there are many sources of radiation both natural and man-made on earth. Thousands of studies have been done indicating humans can greatly reduce the risk of this by reducing the exposure as much as possible.\nThe greatest health risk from radon is the source from the soil and should be tested and mitigated as necessary.\nThe other sources for radon and radiation like granite countertops can also be evaluated to lower the exposure even more.\n*The purpose of this document is for providing some recommendations to consumers regarding some of the potential health risks of radon. ACE Radon should not be used as the sole source for guidance and encourages the general consumer to seek information from other sources.", "label": "Yes"}
{"text": "If you are looking for ways to boost your testosterone levels you may want try taking a Gotu Kola supplement. This little known herb has powerful effects and a long history of healing different ailments. This article discusses the Gotu Kola benefits and side effects and examines its role in natural testosterone boosting. By the way, you can click here to see our Top Testosterone Boosters.\nIt is a plant that usually grows in swamps in South Africa and India. The reason it is so effective in treating different ailments is that it is loaded with phytochemicals, beta-carotene, camphol and campesterol, calcium, magnesium, manganese, phosphorus, potassium, selenium and zinc and Vitamins C, B-1, B-2 and B-3 are just some of them.\nGotu Kola Benefits\n- Gotu Kola is thought to increase testosterone levels because men who take it seem to have lower occurrences of erectile dysfunction and they grow muscle faster.\n- One explanation could be that this herb helps to dilate blood vessels and increase blood circulation to the lower parts of the body. Since an erection is caused by blood rushing to the penis, one is able to get an erection faster and hold it for longer.\n- The same goes for muscle. In order for it to grow as you work out it needs to be well-nourished with protein. This protein is transported to the muscle via the blood vessels so when they dilate they are able to feed the muscles more efficiently.\n- This herb contains ingredients that help heal wounds faster. Traditionally, it was a common form of treatment in the areas where it grows. The leaves are placed directly over the wound for healing to occur.\n- It has many other topical uses and some of them may surprise you. You can place the leaves on sores caused by syphilis (usually difficult to heal), sprains, sore muscles, and believe it or not, snake bite. It is important to note, however, that most of these were ancient uses of the herb.\n- Those who are having a hard time initiating a urine stream should try taking Gotu Kola supplements. It has been known to make it easier for older men to initiate and finish a urine stream.\n- Traditionally, it was observed that women who routinely took this herb did not get pregnant. Although no research has been done to understand why this would happen, it is highly recommended that you don’t take it if you are trying to get pregnant or if you are already.\n- Do you suffer from eczema, psoriasis or any other similar skin condition? Gotu Kola leaves or any creams that contain it may be good for you. It helps sooth inflammation and swelling.\n- People who are looking for mental clarity, an energy boost and mental focus use Gotu Kola. This is because it helps stimulate the nervous system. It could also be because of the dilation of blood vessels that transport more blood to the brain.\n- If you have a cold or you can feel one coming on you should try taking Gotu Kola. It has been known to cure colds, coughs and other respiratory infections.\n- It can help reduce water retention in those who suffer from edema, a condition where the body is not able to expel fluid naturally.\n- Some people say that it helps stimulate appetite. This can be very useful especially for those who are sick or in recovery.\n- Lastly, it seems to have a positive effect on those suffering from anxiety and depression, which again could have something to do with improved blood circulation.\nGotu Kola Testosterone Increases\nAgain, as we already said earlier, those who take Gotu Kola supplements seem to have higher testosterone levels although it is not quite clear how that happens. It would not hurt to include it in your list of supplements if you are working out for muscle growth or if you want to improve your sex life. For men who want to conceive, Gotu Kola testosterone increases seem effective.\nGotu Kola Side Effects\nAlthough the side effects of Gotu Kola are rare, it is important to know what they are. Before we mention them, you should know the best brands of Gotu Kola to buy. There are some on the market that consists of very little extract, the rest being filler. The filler, which is a mixture of chemicals and other ingredients, is the one that causes most side effects. Other than that, Gotu Kola has few side effects such as:\n- Skin sensitivity you may feel like your skin is burning when touched and you may also experience sensitivity to heat and sunlight.\n- Some people develop a rash on the sin. This is usually quite mild and goes away before long.\n- In the first days you may experience headaches and dizziness. Again, these will go away as your body gets used to the herb.\n- Some people have reported nausea and an upset stomach.\nGotu Kola Benefits – Summary\nGotu Kola is an excellent herb that can help you grow muscles, improve your sex life and has many other benefits but you must choose your brand carefully. Gotu Kola is appearing as an ingredient in more and more natural testosterone supplements. Though Gotu Kola is loaded with benefits, including natural testosterone boosting, there are a few rare Gotu Kola side effects.\nI’m not just a supplement analyst. I’m an extremely qualified one! I am a Certified Nutrition Coach (CNC) and actually received my certification directly from the National Academy of Sports Medicine. I am also a Nutrition & Wellness Consultant, certified by the American Fitness Professionals Association (AFPA).", "label": "Yes"}
{"text": "What are the symptoms of cardiomegaly?\nMy mother, (72years) has diabetes and thyroid problem. Recently when she had flu, our family doctor prescribed an X-Ray examination to eliminate swine flue and we noticed she has cardiomegalia.\nI attach all the medical records from doctors consulted and medicines she is taking.\nWe would like to do an exhaustive diagnosis of the actual problem before looking at a possible line of treatment.\nCan you please list out a range of tests that she need do for an accurate diagnosis of her problem after which I will get back to you with the results for a recommendation of a line of treatment.\nannual blood tests to be done\nHi Mr XXXXXXX\nWelcome to HCM. I have gone through the question and understand your concerns.\nSince your mother is having type 2 diabetes and hypothyroidism, she should have some annual blood tests done. This includes:\n2. Renal function tests\n3. Liver function tests\n4. Serum electrolytes, calcium, phosphorus\n5. Blood and urine routine\n6.urine albumin creatinine ratio\n7. Diabetic retinopathy screening by ophthalmologist\n8. Clinical examination for neuropathy and peripheral pulses\n9. Anti TPO antibody - to see if thyroid dose can be reduced\nFor cardiomegaly additional investigations needed are\n1. Repeat chest x Ray to see the previous lung patch is completely cleared\n3. Echo cardiography\nI have gone through the reports uploaded.\nHer diabetes is well controlled - normal HbA1c and FBS.\nHer thyroid function is also normal. TSH is on the lower side. But don't adjust dose based on that as this may be due to the flue or the steroid medication she was on for breathlessness. You can repeat the thyroid function tests after 1 month and adjust dose based on that.\nIt is better to vaccinate her with pneumococcal and influenza vaccine as a preventive measure.\nHope I have answered your questions. If you have any further queries I will be happy to help you.\nDr Ajish TP [MD,DM]\nThank you for your detailed reply. We will indeed carryout the tests prescribed by you. I however have a few more questions on my mother's condition:\n1. Is Cardiomegaly related or as a consequence of the diabetes and thyroid medication taken by my mother?\n2. is it possible to correct cardiomegaly by reducing the dosage or changing the current drugs used for controlling her diabetes and thyroid condition?\n3. Is there any particular drug that she takes now that might cause cardiomegaly and if so can it be eliminated or replaced with some other drug?\n4 If cardiomegaly is a separate condition will she require other drugs apart from the ones she takes for diabetes and thyroid for controlling it.\n5. If cardiomegaly is a separate entity by itself and not related with endocrinology, then who should we contact for an expert opinion. A cardiologist?\nThanks once again,\nSee detailed answer\nWelcome back. The answers to your questions\n1. Cardiomegaly is not related to diabetic or thyroid medications\n2. Cardiomegaly can be seen in both diabetes and hypothyroidism - cardiomyopathy in hypothyroidism and hypertension or cardiac disease commonly associated with diabetes can cause cardiomegaly\n3. Cardiomegaly in X ray may not always be a true Cardiomegaly. So you have to do an echocardiogram to confirm that. Transient Cardiomegaly can be seen in respiratory infections.\n4. The treatment of Cardiomegaly depends on underlying cause.\n5. You should consult a cardiologist for detailed evaluation.\nHope this information was useful to you\nDr Ajish TP\nAs suggested by you, I have got done the various bloodtests for my Mother and attach the report for your comments. Do let me know how to proceed further and what has to be done\nThese investigations are fairly ok\nHi Mr XXXXXXX\nWelcome back. I have gone through the reports.\nMy commends on lab reports:\n1. kidney function tests and liver function tests are normal\n2. Mild albuminuria -This test need to be repeated after 3 months to confirm.\n3. Uric acid high - decrease protein intake ( meat, pulses, spinach etc)\n4. Blood sugar is well controlled ( HbA1c 6.5%)\n5. Urinary infection - pus cells. Do a urine culture and repeat urine examination. Is she having pain while urination?\n6. Thyroid antibodies are high (Hashimoto's hypothyroidism) she need to continue the same dose of thyroid medications, probably life long.\nThese blood tests are fairly ok. Nothing to suggest the cause for cardiomegaly.\nThe next line of action will be.\n1. Do repeat chest X-ray and ECG to confirm if there is cardiomegaly\n2. If there is cardiomegaly, consult a cardiologist and do an echocardiogram to see the cardiac function.\n3. Do a repeat urine examination and culture. If needed antibiotics for urinary infection\n4. Repeat uric acid, urine albumin creatinine ratio after 2 months.\nHope this will help with her further management. If you have any further questions I will be happy to help you.\nDr Ajish TP\nThe User accepted the expert's answer\nGet personalised answers from verified doctor in minutes across 80+ specialties\n- What are the symptoms of callidus\n- What are the symptoms of microadenoma\n- What is std and what are the symptoms\n- Symptoms of cardiomegaly with atheromatous aorta\n- Swollen forearms whats this a symptom of\n- What is vaterl syndrome symptoms\n- What is cardiomegaly\n- What are the symptoms of parkinson disease symptom\n- Mild cardiomegaly signs and symptoms\n- Symptoms of cardiomegaly", "label": "Yes"}
{"text": "Coronavirus has caused havoc all over the world including India. Doctors and scientists from all over the world make new revelations related to it almost daily. Sometimes with the new strain of the virus, sometimes with the diseases caused by it. Scientists have made another shocking disclosure among the cases of fast-growing Black Fungus in corona patients. Scientists have told about the new symptoms of this epidemic.\nFirst case in the world\nAccording to a report by the health website Web MD, the first such case in the world has come to light in which dangerous blood clotting occurred on the side of a corona patient.\nWhy is blood clotting?\nResearchers at Rutgers University in New Jersey say that this is the first case of its kind in the world. This will help them to know how the inflammation caused by the coronavirus is harming the patient’s body and how it can be corrected.\nThese symptoms showed in an 85-year-old patient\nAccording to a recent study published online in the journal Viruses, such blood clotting has been observed in an 85-year-old patient. Let us tell you that earlier cases of blood clotting were reported in the lower parts of the corona patients, but this is the first case of clotting in the upper part of the body.\nNo other signs of corona\nIt is worth noting that the corona report of the patient has come up positive in the investigation but there were no other symptoms of corona in it.\nWho can have this problem\nResearcher Payal Parikh said, “The oxygen level of the patient was not reduced but due to blood clotting in the arm, he had to be admitted to the hospital.” He said that blood clotting occurs due to inflammation in the body or in those people who cannot move much.\nCan be dangerous\nDr. Parikh says that such cases are a matter of concern as blood clot reaches the lungs in 30% of the patients, which can be dangerous.\nWhat to do if you have trouble breathing?\nHe said that after coming to Corona positive, if there are complaints of difficulty in breathing or decreased oxygen level, then the patient should contact the doctor as soon as possible.", "label": "Yes"}
{"text": "Functional Neurology Rehabilitation\nBy evaluating the brain and nervous system in its entirety, we can localize regions that are dysfunctional and misrepresenting sensory information to the brain. Autonomic dysregulation is often seen in neurological patients and we perform careful evaluation of this potential involvement. Oxygen delivery to the brain is an important aspect of brain rehab and is examined thoroughly. We're essentially looking at your brain from an integration perspective, ensuring all regions are sending appropriate afferent information to the brain, including the vestibular system, proprioceptive system, visuomotor system, autonomic system, and oxygenation system. Our core model of care is multi-modal, ensuring that all potential regions that may contribute to your condition are properly assessed to allow for resolution of symptoms. In order to do this, we must reset the Central Integrated State of the dysfunctional neuronal regions of the brain to reduce their resting membrane potential to an appropriate level that is healhy and approximately -65 mV, reducing hyperexcitablity that can cause many of the patient's symptoms. We attempt to achieve this through a specialized program that combines Neurology, Chiropractic, Physical Therapy, Vestibular Rehabilitation, Occupational Therapy and Oxygen.\nNeurology Core Testing Program:\n- Videooculography (VOG, sometimes referred to as VNG) that measure eye movements that relate to specific regions of the brain, brain stem and vestibular system.\n- Sensitive balance and coordination testing of proprioception and brain using Computerized Assessments of Posturography Systems (CAPS) that allow us to measure dysfunctional areas sensory input related to Migraine.\n- Tilt Table Testing\n- Autonomic Assessment\n- Clinical Examination (Neurology, Proprioceptive, Respiration)\n- Gait analysis\n- Oxygen evaluation\n- Metabolic capacity\n- Objective measures\n- Spatial and Temporal Summation (Treatment Plan)\nNeurology Core Treatment Program:\n- Tilt Table Treatment (TTT)\n- Non-Invasive Nerve Stimulation (NINS)\n- Vagus Nerve Stimulation (VNS)\n- Oculomotor retraining (eye movement exercises) (OMR)\n- Vestibular Rehabilitation (VR)\n- Occupational Therapy (OT)\n- Rib Manipulation (RM)\n- Cervicovestibular rehabilitation (CVR)\n- Specific Chiropractic Neurological Manipulations for Oxygenation L/S/T (SCNM-O)\n- Mild Hyperbaric Oxygen Therapy (mHBOT)\n- Postural Restoration (PR)\n- Physical Therapy (PT)\n- Functional Neurological Rehabilitation/Neuroplasticity Retraining Exercises (FNR/NRE)\n- Co-treatment (Botox, Medications, etc..) (CT)\n- Migraine dietary recommendations (MDR)\nWhy so much focus on Neuroplasticity?\nNeurons require Activation, Oxygen and Fuel (glucose) to maintain a healthy state of -65 mV and undergo Immediate Early Gene Response to create more cellular contents such as sodium/potassium pumps, mitochondria for ATP formation, axonal and dendritic connections with neighboring cells, etc. The list you saw is how we target the dysfunctional areas with activation, oxygen and carry fuel to those cells. This has to be done in a very graded, careful manner so as to not exceed the metabolic rate of the neurons involved. We observe metabolic capacity for each individual and maintain levels of treatment that stay below those levels so as to keep a steady progression of healthy return to a normal state of function. Neurons respond through Temporal and Spatial Summation, so we can develop treatment plans based on your severity that will allow maximal response and long-term changes. This is known as Neuroplasticity and is at the core of our Concussion Program. I often tell people, I don't know how much I can help you, but in most cases, we're able to improve individuals at least 50% with the understanding that our goal is much higher. Your response depends on multiple factors, including genetics, central sensitization (chronicity), following our treatment plan and so forth. We are very open and honest with our patients and do our best to provide accurate information, but it is a functional issue and it is sometimes difficult to be exacting in our predictions.\nThe Portland Chiropractic Neurology approach\nPortland Chiropractic Neurology utilizes evidence based treatments in a multi-modal approach, patient centered model that allows individualized diagnosis and treatments by combining Neurology, Hyperbaric Oxygen Medicine (HBOT), Chiropractic, Physical Therapy and Occupational Therapy. It is recommended that evaluation occurs after concussive injuries by a trained professional, such as at PCN. Early intervention is encouraged, but not always necessary. As the leading Chiropractic Neurology office in Maine, the doctors at Portland Chiropractic Neurology (PCN) are highly trained in these areas and have a very successful track record for treatment of Post Concussion Syndrome. Dr. Aaron MacArthur is a Chiropractic Neurologist and has a fellowship in Brain Injury and Rehablitation as well as a fellowship in Vestibular Diagnosis and Rehabilitation. He teaches within the United States on various topics of concussion and migraine care. Dr. Haley Girard is also a Chiropractic Neurologist with extensive training in concussion.", "label": "Yes"}
{"text": "Marine animals take on many fascinating forms. Some are even mistaken for plants. One of the simplest and most primitive of animals is the sponge. This filter-feeding omnivore is really just a stationary colony of living cells attached to one another. The cnidarians (pronounced “nigh-dare-ee-ans”), another fascinating group of simple animals, use stinging cells called cnidocytes (nighdoe-sites) to obtain their food. These cells contain poisonous barbs which paralyze their prey. Sea anemones, jelly fish, and corals are cnidarians found in our local marine waters. Microscopic forms of the sea anemone live in the mud flats at Upper Newport Bay.\nA more mobile group of animals is the echinoderms, which includes sea stars, brittle stars, sea urchins and sea cucumbers. Usually they have 5-part symmetry. In the sea star and brittle star this is immediately apparent. But this 5-part symmetry is also present in the sea cucumber; it is just that this creature lies on its side and has become elongated. A sea star has hundreds of tube feet on the underside of its arms. These are tipped with suction cups that are used to grip the shell of a clam or mussel. The sea star can then turn its stomach inside out and insert it into the bivalve and eat it from within.", "label": "Yes"}
{"text": "Epigenetic regulators play a crucial role in establishing and maintaining gene expression states. To date, the main efforts to study cellular heterogeneity have focused on elucidating the variable nature of the chromatin landscape. Specific chromatin organisation is fundamental for normal organogenesis and developmental homeostasis and can be affected by different environmental factors. The latter can lead to detrimental alterations in gene transcription, as well as pathological conditions such as cancer. Epigenetic marks regulate the transcriptional output of cells. Centromeres are chromosome structures that are epigenetically regulated and are crucial for accurate segregation. The advent of single-cell epigenetic profiling has provided finer analytical resolution, exposing the intrinsic peculiarities of different cells within an apparently homogenous population. In this review, we discuss recent advances in methodologies applied to epigenetics, such as CUT&RUN and CUT&TAG. Then, we compare standard and emerging single-cell techniques and their relevance for investigating human diseases. Finally, we describe emerging methodologies that investigate centromeric chromatin specification and neocentromere formation.", "label": "Yes"}
{"text": "Better care with a personal touch\nArticle first published online: 4 AUG 2010\nCopyright © 2010 American Cancer Society\nVolume 116, Issue 16, pages 3751–3752, 15 August 2010\nHow to Cite\nPrintz, C. (2010), Better care with a personal touch. Cancer, 116: 3751–3752. doi: 10.1002/cncr.25557\n- Issue published online: 4 AUG 2010\n- Article first published online: 4 AUG 2010\nDiscoveries in personalized and complementary medicine from ASCO\nMore than 4000 abstracts were presented at the 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) held June 4 through 8,2010, in Chicago, Illinois. Here are highlights from 3 studies presented there.\nHeart Problems Linked to Genes and Dose Levels\nChildhood cancer survivors who carry specific variants of the CBR gene and also received low doses of anthracycline chemotherapy were much more likely to develop heart disease than patients who received low doses but did not have these genetic variants, according to a study by the Children's Oncology Group. To the authors' knowledge, the study is the first of its kind examining the connection between these genes, anthracycline dose levels,and cardiomyopathy.\nAlthough nearly 80% of childhood cancer patients survive, manymust dealwith health problems such as heart disease later in life. “Once cardiomyopathy develops, it is associated with a 2-year survival rate of less than 50%,” notes senior author Smita Bhatia, MD, MPH, professor and chair of the department of population sciences at the City of Hope National Medical Center in Duarte, California. The medical community has known for 30 years that anthracyclines can trigger heart disease, but they have not been able to establish safe dosage levels or explain the variability of side effects noted among patients who receive the drugs. Carbonyl reductases (CBRs) are enzymes that help metabolize anthracyclines into cardiotoxic substances. For this study, researchers examined the effects of variants in 2 CBR-producing genes, CBR1 and CBR3, on the risk of cardiomyopathy.\nThe case-control study compared 165 childhood cancer survivors who developed cardiomyopathy and 323 survivors with no heart disease. The patients were diagnosed between 1966 and 2008,with approximately 80% treated after 1981. The median age at the time of diagnosis was 7.5 years. Among patients treated with high doses (greater than 250 mg/m2), the patients predictably developed cardiomyopathy regardless of their genotype. However,among those patients who received lower doses, both CBR1 and CBR3 variants were found to increase the risk. Those with the CBR1 variant had a 5.3-fold increased risk of cardiomyopathy compared with patients carrying the low-risk variant, whereas patients with the CBR3 variant had a 3.1-fold increased risk.\nWith higher doses of anthracyclines, other unknown factors likely come into play in causing cardiomyopathy. Dr. Bhatia and colleagues are trying to determine these factors, in addition to finding other mechanisms thatmay contribute to heart disease occurring at low doses. “We're working to establish predictive models to develop preventive interventions in a prospective study with newly diagnosed patients,” she notes. That larger cohort studywill likely take another 4 to 5 years to complete. Dr. Bhatia hopes this model can be used to study other toxicity outcomes of pediatric cancer treatment, such as coronary artery disease and stroke.\nThe study has generated an enthusiastic response based on the possibilities it presents for a more personalized approach to preventing toxicities in pediatric cancer patients. “It's the first inkling that we can begin to do a better job in treatment ifwe can account for these unique differences on an individual or genetic basis,” says Melissa Hudson,MD, director of the cancer survivorship division at St. Jude Children's Research Hospital in Memphis, Tennessee. “I hope this moves forward quickly so we can begin to inform our therapeutic decisions more appropriately.”\nAlternatives to anthracyclines are available, particularly for lower dose treatments. For patients with higher risk diseases, such as acute myelogenous leukemia and sarcoma, high-dose anthracyclines are the main form of chemotherapy used. In those cases, physicians would need to consider increased surveillance and pharmacological interventions to prevent heart damage, Dr. Bhatia notes.\nYoga Improves Sleep, Reduces Fatigue\nA 4-week yoga programdesigned specifically for cancer survivors was found to improve sleep and reduce fatigue in what to the authors' knowledge is the largest randomized controlled study to date to examine the value of yoga in this population. “This study is a creative application of scientific technique to complementary medicine, and there are literally millions of patients who could benefit,” says ASCO President George Sledge, Jr, MD.\nFew treatments for sleep problems and fatigue are effective in cancer survivors, notes lead author Karen Mustian, PhD, MPH, assistant professor of radiation oncology and community and preventive medicine at the University of Rochester Medical Center in Rochester, New York. Both conditions are common among cancer patients: approximately 80% report sleep problems during treatment and 65% continue to have problems after therapy is completed. This study provides hope that a low-cost, nonpharmacological therapy can improve quality of life in these patients.\nThe randomized, phase 2/3 trialwas conducted through the University of Rochester Cancer Center Community Clinical Oncology Program and 9 affiliates. The yoga program was assessed in 410 survivors of early stage cancers (96% of whom were women and 75% of whom were patients with breast cancer) who had received standard chemotherapy or radiotherapy between 2 to 22 months before enrolling in the study. They also needed to have had sleep disturbances qualifying as 3 or higher on a scale of 1 to 10. The patients received either their usual follow-up care or follow-up care along with a standardized, twice-weekly, 4-week yoga program that combined elements from both gentle Hatha yoga and restorative yoga.Patients learned various yoga postures as well as breathing exercises and mindfulness techniques that incorporate meditation, affirmations, and visualizations.\nThe 206 patients who practiced yoga reported greater sleep quality,less fatigue,and a better quality of life, whereas the control group of 204 patients reported an increased use of sleeping medication during the same period. Yoga patients reported a 22% improvement in sleep quality versus 12% in the control group. In addition, the group of patients studying yoga had less clinically impaired sleep than the control group (31% vs 16%) and less daytime sleepiness (29% vs 5%). The control group also increased sleep medication use by 5% whereas the yoga participants reduced their sleep medication use by 21% during the study period.\nFurthermore,the yoga group reported a 42% reduction in fatigue, whereas the control group reported only a 12% reduction after 4 weeks. “We can't say at this point whether other forms of yoga, such as heated yoga or more rigorous techniques, also would mitigate side effects,” Dr. Mustian says.\nChildhood cancer survivors who carry a specific variant of the CBR gene were more likely to develop heart disease when receiving low doses of anthracyclines than their counterparts who did not have the gene variant.\nA 4-week yoga program designed specifically for cancer patients was found to improve sleep and reduce fatigue. The yoga patients also were able to reduce their sleep medication use by 21%.\nOlder women with early stage breast cancer who undergo lumpectomy and receive tamoxifen can safely forego radiotherapy, according to a follow-up study.\nOlder Women with Early Stage Breast Cancer Can Avoid Radiotherapy\nPhysicians at Massachusetts General Hospital in Boston have found in a follow-up study that some women aged 70 years and older with early stage breast cancer can safely forego radiotherapy. Specifically, women who undergo lumpectomy and receive tamoxifen can avoid radiotherapy without significantly affecting their survival. The standard of care for these women with very small tumors that are estrogen receptor (ER)-positive and lymph node-negative has been lumpectomy plus radiotherapy. However, older women are less likely to have aggressive disease or to experience a disease recurrence than their younger counterparts. At the same time, results in earlier cohorts of this study with a shorter median follow-up indicated that the risk of disease recurrence without radiotherapy was only marginally higher, according to lead author Kevin Hughes, MD, surgical director of breast screening and codirector of the Avon Comprehensive Breast Evaluation Center at Massachusetts General Hospital.\n“The benefits of radiation are small,” Dr. Hughes said, noting that this larger study confirms these results and suggests that tamoxifen may replace the need for radiotherapy.\nResearchers randomly assigned 636 women aged 70 years and older with stage I, ER-positive, lymph node-negative breast cancer who had undergone a lumpectomy to receive either tamoxifen (319 women) or radiotherapy (317 women). After 10.5 years, the risk of breast cancer recurrence in the same breast was found to be lower among women who received tamoxifen plus radiotherapy (2%) compared with those who received tamoxifen alone (8%). However, there was virtually no difference noted between the 2 groups in terms of cancer-specific and overall survival.\n“There were no other benefits of radiation—for example, no impact on breast preservation or distantmetastases,” Dr. Hughes adds. He also suspects the rate of disease recurrence would be even lower among these women today because of more precise surgery.", "label": "Yes"}
{"text": "The framework consisted of 4 parts: the research system, protection and control system, evaluation index system and what is tadalafil development system. Shortly after being started on intravenous unfractionated heparin, she developed sudden cardiovascular collapse leading to a cardiopulmonary arrest. Furthermore, we assessed the antioxidant capacity of butylated hydroxytoluene (BHT) and butyric acid, which are known to play a significant role in the welfare of intestinal mucosa.\nThey featured circulating levels of a 22 viagra vs cialis kDa form of bGH up to 700 ng/ml and enhanced growth starting at 6 weeks of age. The IC-1 RNA is then recognized by TLR7, which induces the production of IL-12.\nPhysical and transcript map of a 2-Mb region in Xp22.1 containing candidate genes for X-linked mental retardation and short stature. We sought to determine the time until recovery of adrenal function after long-term GC therapy, and to assess the prevalence and tadalafil 40 mg best price predictors for secondary adrenal insufficiency. Furthermore, two phenylalanine residues in the cytochrome P450 domain were shown to modulate the specificity of hydroperoxy fatty acid rearrangement.\nGlucocorticoids are commonly recommended for symptomatic therapy and well-tolerated adjunctive therapies may help to reduce the necessary dose and associated risks of chronic glucocorticoid use. The results showed neither obvious DNA strand breaks nor oxidative damage with the comet assay, irrespective of the dose and the organ investigated.\nHigh glucose reduces albumin uptake in cultured tadalafil dosage proximal tubular cells (LLC-PK1). PSEUDOCODIUM MUCRONATUM, A NEW SPECIES FROM NEW CALEDONIA, AND AN ANALYSIS OF THE EVOLUTION OF CLIMATIC PREFERENCES IN THE GENUS (BRYOPSIDALES, CHLOROPHYTA)(1).\nIn this tadalafil generic article, we estimate the impact of middle school transition on the body mass index (BMI) of public schoolchildren in Arkansas, United States. Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence.\nThe use of three-dimensional ultrasound improved significantly the reliability of the LUS muscular thickness measurement obtained transvaginally. The probable cause of ovarian failure tadalafil 20mg in these patients is abdominal irradiation.\nEnriched phage selectively bound human CD40 and homed to inflammatory tadalafilo joints in a murine model of rheumatoid arthritis. In the present work, mitotic chromosomes were sorted using flow cytometry and used as template for PCR with primers designed for genomic regions flanking microsatellites.\nDeposition of free cholesterol in the blood vessels of patients with coronary artery disease: a possible novel tadalafil generico 20 mg mechanism for atherogenesis. Binding of FvTox1 by the anti-FvTox1 scFv antibodies, expressed in either Escherichia coli or transgenic soybean roots, was initially verified on nitrocellulose membranes.\nInduction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells. Social deprivation and prevalence of chronic kidney disease in the UK: workload implications for primary care. Finally, the nuclear medicine images were obtained by tadalafila 5mg inserting (131)I in both male and female thyroid parts.\nThe purpose of this study was to evaluate the initial retention characteristics of 5 implant maxillary overdenture designs under in vitro dislodging forces. The MinION detected all of the expected carbapenemases and ESBL genes in five Gram-negative isolates and the mecA tadalafila 20mg gene in an MRSA isolate.\nInefficient experimental designs are common in animal-based biomedical tadalafila research, wasting resources and potentially leading to unreplicable results. The primary afflictions were malignant tumors, alveolar atrophy, or osteomyelitis.\nThe promoter region of the Escherichia coli pepD gene: tadalafil kopen nederland deletion analysis and control by phosphate concentration. Department of Orthodontics, SB University of Medical Sciences Dental School, Tehran, Iran.\nSocioeconomic factors have some impact on antibiotic prescription in young children. To obtain the transverse velocity component a modification of a multiple-beam method is proposed.\nIFN-A subtypes were identified by cloning and sequencing the amplification product. Aortic Endograft and Epithelioid Sarcoma: A Random Association or Causality? Organotypic cultures showed columnar cells simulating in vivo morphology.\nNevertheless, modeling a system poses some challenges of its own: especially the step of model calibration is often difficult due to insufficient data. Factors associated with penicillin-nonsusceptible pneumococcal infections in Brazil. An efficient method has been developed for tadalafil generic cialis 20mg the catalytic oxidation of pollutants that are not easily degraded.\nA second study determined GHB pharmacokinetics following intragastric administration of GHB, GBL, and 1,4-BD. These alterations in gene tadalafil side effects expression are considered critical during carcinogenesis and have been observed in many environmental- and occupational-induced human cancers.\nFrom some cell lines, the antibodies coprecipitate NG2 and type VI collagen, the latter appearing on SDS-PAGE as components of 140 and 250 kD under reducing conditions. Investigation of matrix effects of urine on a what is cialis molecularly imprinted solid-phase extraction. Long-term memory deficit or cognitive impairment has not been found, although further research to rule out residual impairment is needed.\nIf the infected organisms are antibiotic-tolerant species such as Pseudomonas aeruginosa or methicillin-resistant Staphylococcus aureus (MRSA), treatment becomes quite difficult. Activity of erythrocyte aspartate aminotransferases and its stimulation in vitro with pyridoxal phosphate in children with obesity The results show that the simulations can predict the shape of water adsorption isotherms and predict adsorption levels comparable to literature results.\nThis is the first report of triatomines occurring in arboreal nests of coatis. Oxidative stress is generated in plants because of inequalities in the rate of reactive oxygen species what is tadalafil used for (ROS) generation and scavenging. Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots.", "label": "Yes"}
{"text": "Pyruvate decarboxylase (PDC) is one of several enzymes that require thiamin diphosphate (ThDP) and a divalent cation as essential cofactors. Recently, the three-dimensional structures of the enzyme from two yeasts have been determined. While these structures shed light on the binding of the cofactors and the reaction mechanism, the interactions between the substrate pyruvate and the enzyme remain unclear. We have used PDC from Zymomonas mobilis as a model for these enzymes in order to study substrate binding. The recombinant enzyme was expressed in Escherichia coli. High yield, simplicity of purification, high stability and simple kinetics make this model well suited for these studies. Activity measurements in the pH range between 5.8 and 8.5 indicated that a His residue may be involved in substrate binding. Analysis of an alignment of all known PDC protein sequences showed two invariant His residues (His113 and His114) which, according to the crystal structure of yeast PDC, are in the vicinity of the active site. Here we demonstrate that replacement of His114 by Gin does not have a great effect on cofactor and substrate binding. However, the kcat is decreased indicating that His114, may assist in catalysis. In contrast, substitution of His113 by Gin renders the enzyme completely inactive. This mutant has decreased affinity for both cofactors, as revealed by measurements of tryptophan fluorescence quenching. However, this decreased affinity is insufficient to account for the complete loss of activity. Despite its inability to support overall catalysis, this [Gln113]PDC mutant is capable of releasing acetaldehyde from 2-(1-hydroxyethyl)thiamin diphosphate supplied exogenously. It is proposed that upon substrate binding, His113 is placed close to C-2 of the thiazole ring. Subsequent deprotonation of this atom leads to a conformational change that allows a flexible loop (residues 105-112) that precedes His113 to close over the active site. Hence, replacement of His113 by another residue interferes with this closure of the active site and thus disrupts the catalytic process.\nDepartment of Chemistry\nUniversity of Cambridge", "label": "Yes"}
{"text": "Not too long ago, Vitamin D emerged as the star of the show when it came to proactive and preventive health care. Seen as the vitamin essential for bone health, it also was suggested that low levels of vitamin D could be linked to a number of other health complications.\nNow, Vitamin D has once again been thrust into the spotlight — this time because of its link to COVID-19. A recent study showed that out of all its participants, almost 60% of COVID-19 patients were vitamin D deficient when admitted to the hospital. In another study, researchers found there could be a possible link between vitamin D deficiency and COVID-19 severity.\nAs vitamin D is starting to become a focal point of COVID-19 prevention, more and more people are turning to supplements to protect themselves. So, what exactly does vitamin D do? How do we get vitamin D? And when should you turn to supplements to up your vitamin D intake?\nWhy is Vitamin D Important?\nResponsible for increasing intestinal absorption of calcium, magnesium and phosphate, Vitamin D plays a vital role in your overall health. It’s essential for bone density, building your immune system and regulating cell growth, among other key biologic functions.\nResearch has suggested that low levels of this vitamin may be linked to diabetes and heart disease. Studies have shown that people with low levels of vitamin D and high blood pressure had nearly twice the rate of heart attack as those with adequate levels, although the reason was not clear.\nVitamin D may also play a role in a variety of other health problems. For instance, it may help to regulate brain health, including protecting against memory loss and depression. And although more research needs to be done, some studies show that vitamin D may even protect against multiple sclerosis.\nHow to Get Your Vitamin D\nThere are multiple ways to get your daily dose of vitamin D. This can be through diet, supplements and even taking in a little bit of sunshine.\nWhile there are multiple ways to obtain vitamin D, it can be hard to maintain the optimal level – especially through diet or if you live in an area where you can only retain vitamin D from the sun for a few months each year.\n“Part of the difficulty of maintaining vitamin D levels is because there are not a large variety of foods that contain much Vitamin D,” says Kristin Gustashaw, MS, RD, LDN, CSG, clinical dietitian at Rush University Medical Center.\nWith that said, it is still a good idea to add foods with vitamin D to your diet.\nThese are some good food sources:\n- Egg yolks\n- Fatty fish, especially wild-caught salmon and mackerel\n- Canned tuna in water\n- Beef or calf liver\n- Vitamin D-fortified products, including certain cereals, bread, orange juice, yogurt and soy milk\nGustashaw also recommends that you should get out in the sun for at least 15-30 minutes a day – when the sun is available.\n“Consider the amount you get from the sun as extra protection, says Gustashaw. “Be sure to get a constant source from your diet and supplementation all year round.”\nSupplements can also be a great source of vitamin D, especially if you aren’t getting your daily dose through diet or sunlight.\nAccording to Gustashaw, “Adults should get a minimum oft 600 IU of vitamin D each day and 800 IU if over age 70. Children should get 600 IU each day. And infants 0-12 months 400 IU/day.”\nYou can learn more about the daily allowance for vitamin D on the National Institutes for Health vitamin D fact sheet.\nVitamin D and COVID-19\nAs researchers continue to study possible links between vitamin D deficiency and COVID-19, the big question is: “Should I increase my vitamin D intake?”\nThe answer varies from person to person and depends on your vitamin D levels. If you are already experiencing a vitamin D deficiency, it may be a good idea to increase your intake — not just as a preventive measure for severe COVID symptoms but also for your health overall.\n“We know that a large percentage of the population has suboptimal levels of vitamin D. In fact, as many as half of the U.S. population may be deficient in vitamin D,” explains Gustashaw. “This can possibly lead to symptoms including fatigue, tiredness, hair loss, delayed wound healing, decreased immune health, muscle pain and more, with no other known causes.”\nGustashaw says you can determine your vitamin D levels through a blood test. A low level is 25-hydroxyvitamin D less than 30 ng/mL; a severe deficiency is 25-hydroxyvitamin D less than 5 ng/mL.\nIf you determine that you do have a lower than desired level, it always best to talk to your health care provider or dietitian about the best way to boost your vitamin D intake. And be mindful of any medications you may be taking that may affect vitamin D absorption, including steroids (e.g., prednisone); the cholesterol-lowering drug cholestyramide; and the seizure medications phenobarbital (Luminal) and phenytoin (Dilantin).\nWhile Vitamin D toxicity is rare, and known cases are associated more with manufacturing errors, research has not that proven taking much more than the upper limit of the recommended dosage is beneficial. Remember, unless you are trying to replete your stores when deficient, consistently taking excess amounts of vitamin D can, in some cases, lead to renal failure, calcification of soft tissues throughout the body (including in coronary vessels and heart valves), cardiac arrhythmias, and even death.", "label": "Yes"}
{"text": "Local Mile 1 Delivery: $12 or Free with $125 Purchase.\n$24.99 – Sold Out\nThe long, narrow and flat head of the baryonyx from Schleich Dinosaurs is similar to that of a crocodile, making it an especially exciting prehistoric reptile. This dinosaur is believed to have hunted primarily in the water, and could immerse its perfectly shaped snout into the water to catch fish. It also had unusually large and heavy hook-shaped thumb claws to grab prey. All Schleich figures are hand-painted with detailed modelling. 3+ years.", "label": "Yes"}
{"text": "Cancer Policy Monitor: March 1, 2016\nRegulatory Science and Science Policy Sessions at the Annual Meeting\nCancer Research Policy Forum\nSenate Confirms New Commissioner of FDA\nAACR to Co-host Joint Hill Day\nAACR Hosts Inaugural Early Career Scientist Hill Day\nOn Feb. 24, the American Association for Cancer Research (AACR) convened the inaugural AACR Early Career Scientist Hill Day, bringing 15 early career scientists from across the United States to Capitol Hill to share their personal stories about how they have been affected by the funding environment and to advocate for increased medical research funding. Young investigators have been disproportionately affected by the lack of growth in the National Institutes of Health (NIH) budget from 2004 to 2015, and the individuals selected to participate in the hill day are part of a group of more than 14,000 graduate students, medical students and residents, and clinical and postdoctoral fellows who comprise the associate membership of the AACR.\n\"Many of my colleagues are choosing non-research careers because of inadequate and unpredictable funding for biomedical research. These are the next generation of cancer researchers, and if we lose them, we lose progress in the fight against cancer.\" – Shane R. Stecklein, MD, PhD, Hill Day participant and resident, Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center.\nToday, the chance of receiving a research grant from the National Cancer Institute is less than 15 percent, which is just more than half of the success rate in 2003. On average, a researcher today will not receive their first independent research grant (termed an \"R01\") until they are in their early 40s, compared to their mid-to-late 30s in the 1990s. In fact, only three percent of R01-recipients were under the age of 36 in 2010. For researchers just beginning their careers, securing a federally funded research grant is essential. The loss of purchasing power for the NIH and NCI resulting from budget cuts and failure to keep pace with inflation has translated into record-low success rates for grant applications and has also had significant effects on established researchers. The subsequent failure of even previously funded independent investigators to renew a grant can leave them unable to support their trainees, postdoctoral scientists, and laboratory staff:\n\"My PI was forced to let all senior graduate students go on short notice because there was a lack of grant funds to continue paying our salaries. Even now, junior students in the lab are struggling to afford basic research supplies despite applying for grants in every funding cycle for the past two years.\" – AACR Early Career Hill Day Participant.\nThe Hill Day participants thanked Congress for the inclusion of a $2 billion increase for the NIH in the fiscal year (FY) 2016 omnibus bill, which was a strong sign of momentum for the support medical research funding. However, reversing the effects of more than a decade of flat funding will require a commitment to continued, predictable growth in FY 2017 and beyond. Early career investigators represent the future of the cancer research field, but without the support of federal funding for the NIH and NCI, many careers are at the risk of ending before they begin. No one is more capable of conveying this powerful message to Congress than young scientists themselves, speaking to personal experiences that they and their colleagues have experienced. Through efforts like the Early Career Hill Day, the AACR continues to show strong support for young cancer investigators, and by helping to train the next generation of medical research advocates, the AACR is strengthening the collective voice of the research community calling for robust, sustained, and predictable funding increases for the NIH.\n\"Fostering a dialogue between young scientists and policymakers is extremely important. Through my meetings with congressional offices, I was encouraged to learn that legislators are aware and concerned about the exceptionally competitive funding situation being faced by researchers, and are working towards alleviating this problem by increasing the NIH budget.\"\n– Jennifer C. Shing, PhD, Hill Day participant, postdoctoral fellow, Mayo Clinic.\nTop of page\nRegulatory Science and Science Policy Sessions at the AACR Annual Meeting 2016\nOwing to the importance of regulatory science and science policy issues to cancer research, the AACR Annual Meeting 2016, which will be held in New Orleans from April 16-20, will feature 13 sessions addressing key issues in these fields.\nThis year's science policy sessions will include a Town Hall event with the AACR Office of Science Policy and Government Affairs; a policy session discussing the importance of research on electronic nicotine delivery systems (ENDS), including the composition of e-liquid, health effects on the user and those exposed to secondhand aerosol, and how that research informs regulations; and the impact of the Affordable Care Act on cancer research, care, and prevention.\nRegulatory science and policy sessions will include symposia on early-phase expansion cohorts, next generation sequencing (NGS) technologies and the precision medicine initiative, and a review of recent breakthrough therapies approved by the U.S. Food and Drug Administration (FDA). In addition, educational sessions on Saturday, April 16 will cover topics including NGS-based oncology panels and FDA's approaches to regulating biosimilars and companion and complementary diagnostics.\nTop of page\nLive Webcast Registration Available for March 7 Cancer Research Policy Forum Co-hosted by AACR\nOn March 7, 2016, the American Association for Cancer Research (AACR) and Moffitt Cancer Center will co-host an event with support from the Association of American Cancer Institutes (AACI) and in cooperation with the Honorable Gus Bilirakis and the Honorable Kathy Castor to rally congressional support for and raise public awareness of groundbreaking cancer research that is taking place at Moffitt Cancer Center and throughout the nation thanks to federal funding for the National Institutes of Health (NIH) and National Cancer Institute (NCI).\nBecause of the considerable interest in this program, the event will be webcast live starting at 10 a.m. EST.\nRegister here to receive instructions on how to connect to the webcast.\nThe event will feature a distinguished panel of speakers, including Douglas R. Lowy, MD, acting director, National Cancer Institute and two members of the U.S. House of Representatives from Florida: Rep. Gus Bilirakis and Rep. Kathy Castor.\nThe topics to be covered will include the national cancer initiative to be led by Vice President Biden, the Precision Medicine Initiative, current priorities for the NCI, congressional efforts such as the 21st Century Cures legislation, and a patient's perspective on the progress being made in cancer research and treatment.\nRegister for the live webcast.\nDownload the event flyer.\nTop of page\nU.S. Senate Confirms Robert Califf, MD as New Commissioner of FDA\nOn Feb. 24, Robert Califf, MD was confirmed by the U.S. Senate to be the new commissioner of the U.S. Food and Drug Administration (FDA). Despite the vocal opposition of a few senators, Califf was easily confirmed by a vote of 89-4. Califf replaces Margaret Hamburg, MD, who stepped down in March 2015.\nThe AACR had\nendorsed Califf's nomination.\nTop of page\nAACR to Co-host Joint Hill Day to Advocate for Continued Congressional Support for Medical Research\nOn May 12, the AACR will once again partner with the Association of American Cancer Institutes (AACI) and the American Society of Clinical Oncology (ASCO) to build congressional support for federal research supported by the National Institutes of Health (NIH) and the National Cancer Institute (NCI) and to advocate for robust, sustained, and predictable funding increases for the NIH and NCI in fiscal year (FY) 2017 and beyond.\nIn 2015, the AACR-AACI-ASCO Hill Day brought more than 70 researchers, oncologists, and other cancer research advocates to Capitol Hill, where they participated in more than 130 congressional meetings, including meetings with key House and Senate leadership. Participants called on lawmakers to support funding increases for the NIH and the NCI to continue to make progress in the fight against cancer.\nIn addition to the day of congressional meetings, the partnering organizations hosted a reception the evening before where they honored champions of cancer research and biomedical science. Last year, Senators Richard Burr (R-N.C.) and Barbara Mikulski (D-Md.) were recognized for their outstanding leadership and tireless efforts in advocating for predictable and robust funding increases for cancer research through the NIH and NCI.\nFor more information or to register for the Joint Hill Day, please contact James Ingram.\nTop of page", "label": "Yes"}
{"text": "Diagnosis of Trigeminal Neuralgia\nAlthough a number of conditions can cause facial pain, the symptoms of trigeminal neuralgia are very specific. An initial diagnosis often can be made by taking a detailed medical history and performing a physical examination. A dental exam can help determine if the teeth or gums are causing the pain.\nTo confirm the diagnosis, other conditions that can cause facial pain (e.g., infection of the jaw or sinuses; fibromyalgia; migraine; Bell's palsy) and other types of nerve disorders (e.g., trigeminal neuropathy) must be ruled out. Trigeminal neuropathy causes weakness, numbness, and a loss of sensation, in addition to facial pain.\nDiagnostic tests, such as computed tomography (CT) scan, magnetic resonance imaging (MRI) scan, or magnetic resonance angiography (MRA), also may be performed to help detect other conditions.\nIn CT scan, x-rays are taken from different angles and are used to create a cross-sectional image (called a tomogram) of structures in the body (e.g., brain, skull, sinuses). This test can be used to detect blood clots, tumors, and infections.\nMRI scan uses electromagnetic radio waves to create detailed images of organs, tissues, and nerves. MRI can be used to detect strokes, aneurysms, and tumors.\nMagnetic resonance angiography is a special type of magnetic resonance imaging scan that is used to produce images of blood vessels (e.g., veins, arteries). This test is used to detect blood vessel abnormalities and to evaluate blood flow.\nUnderlying conditions that can cause facial pain and that must be ruled out include the following:\n- Cancer (e.g., lymphoma, throat cancer)\n- Certain medications\n- Guillain-Barre syndrome\n- Infections (e.g., otitis media, mastoiditis)\n- Injury (trauma)\n- Multiple sclerosis (MS)\n- Tumors and other lesions (e.g., aneurysm, neurofibroma, neuroma)\n- Viruses (e.g., herpes zoster)", "label": "Yes"}
{"text": "Eating a balanced diet is a necessity for anyone needing food health. The components of vitamins, proteins, and carbohydrates constitute a balanced diet. But then again, vitamins have a different classification that each have different roles in the body. All these types have a different positive impact on our health. Vitamin C is one among many types of vitamins. One of the major benefits of taking Vitamin C is that it helps in the immune system improvement. But on the other hand, there are many more benefits of taking vitamin c. On the other hand, one may also consider taking the Vitamin C supplement option taking. Therefore, discussed below are some of the advantages that come with the intake of food rich in Vitamin C or Vitamin C intake.\nBy taking sources of Vitamin C, reduction of getting chronic diseases is facilitated. The major aspect that helps in this is the antioxidant present in the vitamin C sources that helps in the strengthening of one’s body defenses. As mentioned earlier, it helps in the boosting of one’s immune system a factor that is enhanced by the antioxidant that is contained in the Vitamin C. The antioxidant prevents the cells of the body from being harmed by the harmful molecules that could be in the body. Hence, prevention of contacting of chronic disease is effective.\nThe second advantage associated with Vitamin C intake is the reduction of high blood pressure. High blood pressure is one of the problems that is experienced by the highest population. Thus the need to take food rich in Vitamin C to make sure that the high levels are maintained. It is advisable that an individual with high blood pressures take Vitamin C supplements to avoid being at risk of getting heart diseases that might cause death if that individual at the maximum. When one takes Vitamin C, the vessels that carry blood are relaxed hence pressure is reduced. It is also a must or one to consumes source of Vitamin C to avoid getting high blood pressure and those who do not want to get.\nTo conclude with is the richness of the Iron components factor. In that it prevents deficiency of Iron in the body. The reason being that iron is a necessary component in one’s body. Iron helps in the making of the red blood cells and helps the transportation of oxygen in the body. For those that have been recommended to not take meat at all, Vitamin C is essential as it plays the role that the meat could have when they consumed meat. Vitamins C intakes prevent one from suffering from anemia that is caused by the deficiency of iron in the body.", "label": "Yes"}
{"text": "As we get older, our bodies start making less human growth hormone (HGH). This normal fall in HGH levels can contribute to many age-related problems, like weight gain, decreased energy, and diminished muscle mass.\nHGH pills like GenFX promise to help raise your body’s own HGH production safely and healthily. Let’s take a deeper look at what GenFX is, how it works, its components, advantages, and any adverse effects.\nWhat is the GenFX HGH Releaser?\nGenFX is an HGH releaser supplement developed by a business named Leading Edge Health. It comprises a combination of amino acids, botanicals, and other natural substances that are supposed to help stimulate your pituitary gland to create more HGH.\nHGH stands for human growth hormone. It’s a hormone generated naturally by the pituitary gland that plays a function in growth, cell regeneration, and metabolism. HGH levels peak throughout adolescence and start falling around age 30.\nGenFX and other HGH releasers seek to help slow down and reverse some symptoms of aging by enhancing your body’s natural HGH production. They don’t contain as much genuine HGH as synthetic shots do.\nHow does the product work?\nGenFX claims to operate through a mixture of amino acids, herbs, and minerals that are believed to stimulate the pituitary gland and enhance HGH synthesis.\nSome of the main components include:\n- L-arginine is an amino acid that has a function in HGH secretion.\n- L-glutamine is another amino acid considered to help enhance HGH.\n- L-glycine is an amino acid that may activate the pituitary gland.\n- GABA is gamma-aminobutyric acid, a neurotransmitter that may enhance HGH synthesis.\n- Deer antler velvet contains insulin-like growth factor-1 (IGF-1), which increases HGH.\n- Tribulus terrestris is a plant used in traditional medicine to revitalize hormones.\nAccording to the manufacturer, this mix of substances impacts the pituitary gland and brain to promote growth hormone output naturally.\nGenfx Ingredients List\nThe primary active components in HGH product include:\n- Amino acids: L-Arginine HCL, L-Glutamine, L-Glycine, L-Lysine, and L-Tyrosine\n- Herbs: Tribulus terrestris extract, deer antler velvet, astragalus root extract\n- Vitamins and Minerals: Vitamin B6, Magnesium, Zinc, and Chromium\n- Other: Phosphatidyl Choline, GABA, and Colostrum\nIt also contains inert substances, including gelatin, magnesium stearate, and silicon dioxide. The entire natural ingredients list may be obtained on the GenFX website.\nAll the components are natural and supposed to act synergistically to promote HGH synthesis in the body. However, additional study is still needed on the usefulness of these particular substances for raising HGH.\nBenefits of GenFX GH Releaser\nAccording to the company, GenFX can deliver benefits like:\n- Increased lean muscular mass and strength\n- Weight reduction and reduced body fat\n- Wrinkle reduction and improved skin elasticity\n- Sharper memory and enhanced mood\n- More energy and endurance\n- Better sleep quality\n- Enhanced sexual desire and performance\nThese advantages are related to the possible HGH-enhancing effects of GenFX. By raising HGH levels, it may help offset certain natural consequences of aging.\nHowever, keep in mind that individual outcomes might vary quite a bit. Some users have experienced considerable anti-aging results, while others see just mild or no improvements. Like any supplement, GenFX may work better for some people compared to others.\nRisks and Side Effects of GenFX\nThe company claims GenFX is produced from natural substances that don’t cause bad responses when taken as indicated. But there are some potential adverse effects to consider:\n- Upset stomach, nausea, diarrhea – digestive difficulties related to substances like deer antler velvet\n- Headache and dizziness come from amino acids such as L-arginine and L-tyrosine.\n- Facial edema is an uncommon incidence associated with deer antler velvet allergy.\n- Hormone imbalance: a potential concern if HGH levels grow too high.\nThe aforementioned side effects seem to be infrequent and typically minor, based on customer evaluations. Still, it’s a good idea to watch out for them before starting GenFX.\nGenFX is not suggested for pregnant or breastfeeding women as it might influence hormone levels. People on drugs or with a medical condition should visit a doctor before taking them to check for interactions.\nOverall, GenFX looks generally safe for most healthy individuals when used as prescribed. But there’s no long-term safety evidence available due to it being a very new supplement. Moderation and cycling on and off periods are suggested.\nThe Science Behind GenFX Growth Hormone Booster\nGenFX is an anti-aging pill that claims to raise human growth hormone (HGH) levels naturally. But what precisely is HGH, and how can GenFX stimulate its synthesis in the body? Let’s look at the research behind this supplement.\nWhat is Human Growth Hormone (HGH)?\nHGH is a crucial hormone generated and released by the pituitary gland. It plays an essential role in growth and development in children and adolescents.\nIn adults, HGH helps control body composition, muscle and bone development, sugar and fat metabolism, and perhaps cardiac function. HGH levels peak around puberty and start falling after age 30.\nHow does HGH affect the body?\nSome of the important roles and consequences of HGH in adults include:\n- It increases protein synthesis and boosts muscular growth.\n- Boosts lipolysis – the breakdown of fat \n- Improves exercise capacity and endurance\n- Regulates blood sugar levels \n- May increase cardiac function and bone density.\n- Enhances skin thickness and elasticity\n- Stimulates collagen production for anti-aging effects\nThis explains why HGH pills are utilized by certain people for muscle gain, weight loss, and anti-aging goals.\nHow Does the Booster Increase HGH Levels?\nGenFX includes amino acids, herbs, and other nutrients that are claimed to encourage the pituitary gland to release more HGH naturally.\nKey components, including L-arginine, L-lysine, L-glutamine, and GABA, have demonstrated potential to enhance growth hormone levels in human and animal research.\nFor example, arginine can boost HGH secretion by reducing somatostatin, a hormone that limits HGH release.\nBut several chemicals need greater doses than what is contained in GenFX to be effective. More studies are still needed on the appropriate dosages and combinations.\nThe Role of Amino Acids in GenFX\nAmino acids make up a large percentage of the GenFX recipe. Here are some of the major amino acids considered to enhance HGH release:\n- L-Arginine is shown to enhance resting HGH levels at dosages of 5–9 grams per day.\n- L-lysine may act synergistically with arginine to enhance HGH.\n- L-Glutamine: Anecdotal evidence shows 2–5 grams per day may boost HGH.\n- L-glycine stimulates the hypothalamus to produce HGH in animal models.\nThese amino acids presumably operate via diverse methods to boost HGH release from the pituitary gland.\nThe Impact of growth hormone on Muscle, Fat Loss, and Energy Levels\nBy boosting HGH levels, GenFX intends to provide benefits like:\n- Increased lean muscular mass: HGH promotes protein synthesis. \n- Reduced body fat: HGH stimulates fat metabolism.\n- Higher energy levels: HGH boosts exercise capacity.\nBut the degree of these benefits, if any, depends on the capacity of GenFX to dramatically enhance HGH levels using its formula.\nUsing GenFX: Dosage, Results, Safety, and Precautions\nInterested in trying GenFX for anti-aging benefits? Here’s a brief explanation of how to use it appropriately, what outcomes to expect, and any safety precautions.\nHow to use\nGenFX comes in easy-to-swallow pills. The suggested usage is:\n- Take 2 capsules every day with meals.\n- One capsule in the morning, one at night.\n- Take on an empty stomach at least 2–3 hours after eating.\n- Cycle on and off; use for 3 months, then take 1.5 weeks off.\nSpreading out the daily dose helps maintain constant HGH stimulation throughout the day and night.\nThe typical GenFX dose is:\n- 2 pills per day\n- 1,000 mg of total formula per pill\n- So 2,000 mg of total formula per day\nThis is the dose utilized in clinical investigations of GenFX for safety and effectiveness. Exceeding 2 capsules daily is not suggested.\nHow long until you see results?\nAs with other supplements, let at least 2-3 months of constant use determine whether GenFX produces any good results for you.\nPotential advantages, including enhanced skin, energy levels, endurance, and muscle gain, emerge gradually over weeks and months as HGH levels increase. Patience is crucial.\nIs GenFX Safe?\nGenFX is constructed of natural amino acids, plant extracts, vitamins, and minerals that are regarded as safe for most healthy individuals. Side effects are often modest, including upset stomachs, headaches, or dizziness in some individuals.\nBut it’s not suggested for pregnant or nursing women or individuals on drugs owing to probable interactions. Those with medical issues should visit a doctor beforehand.\nSome precautions to bear in mind:\n- Don’t exceed the dosage of 2 capsules daily.\n- Monitor for any adverse effects.\n- Avoid if sensitive to any components.\n- Can take with or without meal\n- Store in a cool, dry area away from the sun.\nAs with any new supplement, it’s advisable to start with a smaller dose and gradually increase it. Be sure to follow the packaging directions.\nBenefits and Risks of Using the Supplement\nGenFX is an anti-aging HGH supplement that might have advantages but also has possible negatives to consider. Here is an outline of the benefits and downsides.\nSome possible advantages of GenFX include:\n- Increased lean muscular mass and strength\n- Enhanced fat burning and weight loss\n- Improved skin elasticity and a decrease in wrinkles\n- More energy, endurance, and exercise capability\n- Better sleep quality\n- Elevated mood and cognitive function\n- Stimulation of collagen synthesis for anti-aging effects\nThese advantages are linked to GenFX’s capacity to enhance growth hormone levels. But the real advantages will differ individually.\nRisks and side effects\nSome potential harmful effects to be aware of are:\n- Headaches, dizziness, and nausea are caused by components such as amino acids.\n- Allergic response in sensitive individuals, notably to deer antler velvet\n- Facial edema, an uncommon adverse effect connected to velvet antler\n- Hormone abnormalities if HGH grows too high\n- Increased insulin resistance: a theoretical risk\nSide effects seem pretty modest to most people. But long-term safety is unclear.\nInteractions with Medications\nGenFX might potentially interact with:\n- Diabetes drugs may impact blood sugar control.\n- Anticoagulants and antihypertensives: deer antler may increase hazards\n- Sedatives: substances like GABA might improve effects.\n- Levothyroxine: potential for decreased absorption\nConsult a doctor before taking any drugs.\nWho should avoid the supplement?\nGenFX is not recommended for:\n- Pregnant or breastfeeding women\n- Children and teens under 18\n- Those with hormone-sensitive malignancies\n- People with uncontrolled diabetes\n- Anyone with a major medical condition\nHealthy people should first visit their physician to rule out any hazards.\nThe long-term implications of changing HGH levels are not yet completely established. Prolonged usage might possibly lead to:\n- Permanent pituitary gland dysfunction\n- Increased risk of diabetes owing to insulin resistance\n- Potential tumor growth stimulation\nCycling on and off GenFX is encouraged, so be cautious. Further study on long-term safety is still needed.\nHow GenFX Compares to Other HGH Boosters and Supplements\nWith so many HGH supplements on the market, how does GenFX match up against the competition and synthetic injections? Here’s an outline of how GenFX compares.\nGenFX vs. Synthetic HGH Injections\n- Boosts natural HGH production\n- Oral capsules rather than injections\n- No prescription is necessary.\n- Lower cost than injections\n- Faster and dramatic outcomes\n- HGH instantly enters circulation.\n- Higher and consistent HGH doses\nInjections deliver synthetic HGH directly, whereas GenFX tries to boost your natural HGH synthesis. Injections are more potent but require a prescription and medical supervision.\nGenFX vs. other growth hormone releasers\n- Established brand with clinical studies\n- Contains important amino acids like arginine and lysine.\n- Includes deer antler velvet and astragalus\n- Positive customer reviews\n- The proprietary formula lacks dose transparency.\n- There are fewer GenFX ingredients than some rivals.\n- Mixed reviews from certain users\nOther releasers may deliver more diversified chemicals at larger dosages. But GenFX seems to perform effectively for individuals wanting a high-grade basic HGH supplement.\nWho Should Consider GenFX?\nGenFX may be preferred by people who:\n- Want an established brand with some backing\n- Prefer a simple recipe with crucial components\n- Seek the convenience of oral capsules.\n- Have budget limits.\nHealthy people over 30 (mostly without HGH deficiency) searching for modest HGH stimulation may benefit most from GenFX. Those seeking the greatest anti-aging advantages may opt for prescription HGH.\nGenfx Review Conclusion\nGenFX is an HGH supplement that helps to stimulate growth hormone synthesis naturally for anti-aging benefits. It includes amino acids like L-arginine and L-lysine, along with botanicals like tribulus terrestris and deer antler velvet.\nThese substances are considered to stimulate the pituitary gland to boost HGH release in the body. By boosting HGH levels, GenFX may aid with developing muscle strength, reducing fat, improving skin, enhancing cognition, and more, depending on the benefits of human growth hormone.\nHowever, while GenFX is generally safe when used as prescribed, the data for its efficacy is still considered preliminary. There are also some possible adverse effects and long-term hazards that require additional investigation\nCompared to synthetic HGH injections that infuse foreign HGH directly, GenFX tries to promote your own natural synthesis. But the outcomes may not be as striking as injections. When compared to other supplements, GenFX has a solid core formula but lacks the greater potencies and diversity of some competitors.\nIn conclusion of our review, GenFX might deliver mild HGH-boosting effects for certain people, notably healthy adults over 30 searching for convenience and a fair price range. Also, talk with your healthcare physician to decide if GenFX is appropriate for your case. While encouraging, further clinical research on GenFX is still needed.\nMike Lilley is the author of many articles and reviews on our site. He is a fitness & bodybuilding blogger and co-founder of Boost Hormone. He writes product reviews based on the results of scientific research. From the great variety of information and products in this niche, he recommends only those that include science-based nutritional ingredients. Find Mike Lilley at SelfGrowth.\n- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180987/ – The effects of growth hormone on adipose tissue: old observations, new mechanisms\n- https://academic.oup.com/edrv/article/30/2/152/2355062 – Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects\n- https://pubmed.ncbi.nlm.nih.gov/17336736/ – Growth hormone effects on protein metabolism", "label": "Yes"}
{"text": "All cancers are driven by genetic mutations that develop in people's body cells over their lifetime. However, what causes these mutations is still largely unknown. Now, researchers have released the findings of a large-scale study that sheds light on these processes. Investigators analyzed the genetic makeup of 30 common cancers in thousands of patients and identified 21 patterns of mutation, or “signatures”, underlying cancer development. All cancer types had at least two signatures, and some had up to six, reflecting the multiple influences that contribute to cancer. The researchers also uncovered the biological processes behind many of these signatures, such as aging or enzymes involved in fighting off virus infections.", "label": "Yes"}
{"text": "Aphids are a pest many gardeners are aware of. They’re a constant risk season after season, attacking 1000’s of backyard vegetation and inducing 1000’s of sighs from gardeners worldwide. Aphids are so frequent as a result of there are such a lot of species, every with a distinct look and preferences for various vegetation.\nUnderstanding which sort of aphid you’re coping with will help you assess potential harm and decide one of the best methods to resolve the issue. There are too many aphid species to debate every intimately, so let’s take a look at the most typical culprits in residence gardens.\nBe careful for these 11 various kinds of aphids in your yard – you’ll come throughout at the least considered one of them. Happily, most of them will be managed with the identical strategies coated on this video:\nAnybody with expertise rising brassicas will likely be well-versed within the harm the cabbage aphid can do. This species (Brevicoryne brassicae) impacts all members of the brassica group however is especially problematic for common greens like cabbage, Brussels sprouts, broccoli, and cauliflower.\nCabbage aphids are a greyish-green colour. Nevertheless, they normally seem extra gray or white up shut because of the waxy coating on their our bodies. Nymphs might have a brighter inexperienced hue till this waxy coating develops. However in the event you spot aphids in your brassicas, you will be fairly sure this species is the wrongdoer.\nThrough the cooler months, aphids lay eggs within the nooks of brassica leaves, hatching in spring and inflicting havoc across the backyard. Newly planted brassicas are extra weak to wreck, as these aphids like to assault tasty and tender new development.\nWith a cabbage aphid infestation, you’ll see wrinkled or deformed leaves, discoloration, and finally stunted development. They’ll additionally transmit damaging illnesses like cauliflower mosaic virus and cabbage ring spot virus, probably ruining your whole crop for the season.\nAlso called the cotton aphid, Aphis gossypii is a standard backyard pest attacking varied vegetation. You could assume they’re primarily problematic for melons or cotton on account of their frequent identify, however they will additionally assault citrus, carrots, and varied decorative vegetation within the backyard.\nWith regards to colour, most are mild or darkish inexperienced – so darkish that they seem virtually black. Youthful aphids can seem virtually yellow in colour. You’ll spot these pests congregating across the undersides of leaves, the place they quickly reproduce in winged and wingless bugs to unfold across the backyard.\nMelon aphids stunt the expansion of vegetation by feeding on new leaves and the guidelines of stems, stopping additional growth and weakening the plant. Together with this bodily harm, they will additionally carry points with sooty mould or illnesses like watermelon and cucumber mosaic virus.\nWhereas many aphids are deterred by excessive warmth and sluggish their replica in summer time, melon aphids aren’t bothered by excessive temperatures, turning into notably harmful for gardeners in hotter zones throughout spring and summer time.\nTwo kinds of aphids are frequent on potato vegetation – the potato aphid and the species coated subsequent, the inexperienced peach aphid. Potato aphids are barely much less frequent than inexperienced peach aphids, however they will nonetheless significantly harm your potatoes, tomatoes, and varied different crops.\nMacrosiphum euphorbiae are fairly straightforward to identify because of their giant dimension and vivid colour. There are pink and inexperienced varieties, and younger nymphs are simply as vivid. Additionally they secrete plenty of honeydew that pulls ants and results in the event of sooty mould on all components of the plant.\nPotato aphids feed on new development, inflicting the leaves to wrinkle and the stems to droop. In giant numbers, their feeding can even end in stunted development that impacts total growth, probably risking your harvests.\nSmall colonies of potato aphids aren’t at all times a significant concern, and pure predators will usually get to them earlier than they will decimate a plant. Nevertheless, you’ll must step in if pure predators are restricted and an infestation will get uncontrolled.\nInexperienced Peach Aphid\nOne of the vital frequent backyard aphids is Myzus persicae, the inexperienced peach aphid. This pest assaults many vegetation, together with potatoes, peppers, spinach, corn, lettuce, and stone fruits. Additionally, you will discover them in your decorative vegetation, comparable to asters and dahlias.\nMature inexperienced peach aphids are usually a pale inexperienced or brown colour, whereas nymphs have a lighter inexperienced or yellow hue. Winged adults are the identical pale colour however have a black head and blotch on the stomach. Infestations usually begin on the decrease leaves of the vegetation, making them barely more durable to identify.\nInexperienced peach aphids may cause comparable bodily harm to vegetation to different aphids, together with deformed leaves and weak stems. Nevertheless, their actual hazard lies of their capacity to unfold illnesses quickly from one plant to the following.\nThis species is a vector and service for a lot of plant viruses and prefers spreading to numerous vegetation reasonably than congregating on only one. Winged inexperienced peach aphids journey continuously from one plant to the following, turning into a critical concern (particularly in edible gardens).\nThe artichoke aphid is discovered on many vegetation – notably timber and shrubs. However with regards to edible vegetation, probably the most harm is finished to artichokes. Overwintering on host timber like oleaster, the winged adults transfer to artichoke vegetation within the hotter months, the place they shortly weaken buds.\nThis species (Capitophorous elaeagni) appears fairly just like the inexperienced peach aphid. The bugs are typically a paler inexperienced or yellow, virtually translucent towards inexperienced foliage. They’re one of many major pests of artichoke vegetation, doing critical harm if not managed early.\nLike different aphids, this species hides between the leaves and sucks on the sap of the foliage and stems. This causes the leaves to wrinkle and alter colour, indicating stress. This stress and harm draw vitality away from the plant and weaken bud growth, inflicting the stems to droop beneath their weight.\nEncouraging predators of this species into the backyard earlier than they take maintain is without doubt one of the greatest methods to restrict harm. A number of beetles and lacewings love munching on artichoke aphids, so ensure they really feel at residence in your yard. Yarrow and flowering dill are some nice companion vegetation for artichokes.\nScientifically often called Aphis nerii, the oleander aphid impacts many decorative vegetation frequent to residence gardens. Evident within the identify, oleander is a major goal, however they’re additionally identified to assault milkweeds (therefore their different frequent identify, milkweed aphid).\nOleander aphids are extremely straightforward to identify on account of their distinctive coloring. Their our bodies are so vivid yellow that they are often noticed from far-off in giant colonies. You’ll discover the legs and antennae are stark black whenever you stand up shut.\nThe vegetation this species assaults are fairly resilient, which means a lot of the priority is beauty. The colonies make the plant look unpleasant and trigger deformed leaves and development ideas that may influence the longevity of younger vegetation particularly. Additionally, you will spot sooty mould on the leaves that may influence photosynthesis.\nThe principle downside with oleander aphids is that they unfold quickly. Sexual replica will not be crucial for offspring manufacturing on this species, permitting for exponential development at fast charges.\nAcyrthosiphon pisum is without doubt one of the most outstanding pea pests, affecting different legume household vegetation.\nPreferring cooler temperatures, you’re most definitely to identify these aphids within the cooler days of spring quickly after planting your legumes, with populations dwindling within the warmth of summer time. Nevertheless, if not managed early, they will return with a vengeance within the fall.\nPea aphids are fairly giant in comparison with different species, with inexperienced our bodies and lengthy legs. They are often robust to identify, hiding out between leaves. However as soon as colonies develop and unfold, you’ll discover them gathering collectively. Additionally, you will spot the deformed leaves and discoloration they depart behind.\nRelying on what you need to plant, you may search for legume varieties resistant to those pests. If not, maintain a detailed eye out for indicators of infestation and take away them instantly.\nBlack Bean Aphid\nOne other aphid that assaults legumes, together with a number of different decorative vegetation, is the black bean aphid. Aphis fabae seems on many bean vegetation and crops like spinach, beetroot, and celery. Additionally, look out for infestations in your nasturtiums.\nFortunately, black bean aphids can simply be picked out on account of their darkish coloring. Most are both black (therefore the frequent identify) or darkish brown and stand out on leafy inexperienced vegetation. Additionally they like to stay collectively in dense teams, creating giant darkish clusters that sign an issue.\nSmaller vegetation can shortly defoliate as a result of they collect in giant teams and suck the sap out of leaves and stems. Bigger vegetation will develop curling leaves and stunted development, with the physiological harm worsening as colonies develop. These aphids additionally carry viruses that may notably harm your edible vegetation.\nAphid predators are extremely useful in managing infestations. Smaller teams may also be sprayed off the plant with a jet of water. But when your vegetation are struggling, stronger controls could also be required.\nInexperienced Apple Aphid\nAphis pomi is a frequent pest of apple timber, particularly younger timber which can be nonetheless turning into established. Whereas apples are the first goal, this species can also be identified to infest different timber like pears and hawthorn.\nTrue to the identify, inexperienced apple aphids are a pale inexperienced or yellowish colour and may look virtually translucent. The adults even have three black cornicles that stick out of the again of the stomach, making this species comparatively straightforward to determine.\nFocusing on new shoots and leaves, Aphis pomi is probably the most damaging to younger timber. They’ll stunt development early on and negatively influence fruiting, though established timber are normally robust sufficient to deal with these bugs. If the infestation is extreme, the colonies might unfold to the fruits.\nSince these aphids can overwinter on branches and spurs, eradicating them as quickly as you notice them is greatest. The earlier you take away them, the stronger your timber will likely be, and by extension, the higher your harvest.\nWoolly Apple Aphid\nWoolly apple aphids additionally have an effect on apple and pear timber however are much more damaging than inexperienced apple aphids. Additionally they look completely different – nearer in look to mealybugs because of the waxy protecting substance they produce.\nGrownup woolly apple aphids are purple or brown, however this colour is difficult to identify beneath the white strands of wax that cowl the colonies and defend them from harm. This formation creates a woolly look that lends the species its identify.\nWoolly apple aphids are primed to assault younger timber and any broken areas of established timber. As soon as they discover a weak level, the bugs settle in, masking branches and feeding on bark to additional the issue.\nSwollen areas will seem on smaller branches and may unfold to the roots, worsening over time. It’s important to forestall these issues by eradicating the aphids as quickly as doable (with a powerful blast of water or a diluted neem oil spray) and implementing preventative measures to keep away from points sooner or later.\nRose lovers will doubtless already learn about rose aphids, scientifically often called Macrosiphum rosae. These annoying bugs have an effect on roses worldwide, notably within the hotter months of spring and summer time. They love to collect round new shoots and buds, negatively impacting new development and flowering.\nMacrosiphum rosae seems in different colours, mostly pink and inexperienced. They could mix in from afar however are straightforward to identify up shut because of the dense groupings they type round weak areas of recent development.\nAphids aren’t majorly damaging to rose vegetation except they’re current in uncontrollable numbers. Backyard predators normally do the give you the results you want in summer time, permitting you to take pleasure in a flush of flowers earlier than temperatures drop.\nIf you’re anxious about an early infestation, you may choose the bugs off by hand, spray them off with water, or use natural controls to handle their unfold.\nNobody desires to cope with aphids within the backyard. Sadly, as the range between species signifies, these frequent bugs are arduous to keep away from. Understanding the different sorts will help you assess the potential harm and develop the perfect motion plan.", "label": "Yes"}
{"text": "Amalur is an orphaned two-fingered sloth (Choloepus Hoffmanni) in Toucan Rescue Ranch’s care. She is one of our youngest orphaned sloths at the moment. Found on the ground with no mom, she was luckily rescued and brought to the Toucan Rescue Ranch. She weighs 746 grams and is receiving milk every 6 hours. She LOVES munching on fresh leaves and is becoming more reliant on solid foods. Our hope is to release her back into the wild once old enough. Amalur has a very long road before that happens. So she will enjoy Sloth Elementary at Toucan Rescue Ranch until she slowly starts to graduate through our Saving Sloths Together program.\nWhy do Sloths Need Help?\nHistorically, sloths have been a highly successful arboreal species however, growing human interactions and development in Costa Rica have made it difficult for them to thrive. As humans move further into the forests and coastlines, destroying natural habitats, sloths have been negatively impacted and greater numbers are dying. Couple this with the growing social media trends and publicities, sloths are faced with more threats to their survival than ever before.\nWhat Dangers do Sloths Face?\nSloths are rescued for various reasons. Common incidents include electrocution from power lines, car accidents, dog attacks, and human encroachment such as deforestation and the illegal pet trade. Oftentimes, baby sloths suffer from injuries and the loss of their mother from such incidents. Babies are often found abandoned by their mother for unknown reasons. (Likely the mother was involved in an accident.) To help with this ongoing issue with sloths, Toucan Rescue Ranch established a program called Saving Sloths Together with another organization in Costa Rica called The Sloth Institute of Costa Rica. Together, we rescue hurt sloths and give them a second chance at life with the goal of releasing them back into the wild once “graduated” from the rehabilitation and release program.\nA unique component of this program is the ability to take a hand-raised, orphaned sloth and give it a second chance at being wild. The concept of releasing captive-raised sloths back into the wild is a feat that has rarely been done with success. However, the combined expertise and resources of the SST project is eager to prove that sloths don’t belong in cages but #backinthetrees because they were all #BornToBeWild.\nStages of the TRR Release Program\n• Pre-school: Newborn to 3-months old. The focus is on growing and drinking their milk! Start to taste various solid foods but isn’t the main diet staple yet.\n• Elementary School: Less than 6-months old. At this stage, the focus is on eating more solids and getting more climbing practice while still staying close to the nursery for warmth and milk.\n• Middle School: 6-months to 1-year. Solids make up most of the diet at this point. Focus on climbing more, becoming more nocturnal, and being more independent.\n• High School: 1-year – 1.5-years. Weaning completely off milk. Focus on growing large enough and independent enough for the “classroom” enclosure.\n• University: 1.5-years+, graduate to the Pre-Release Enclosure – focus on eating more wild foods, weather, environmental changes, total independence, etc.\nItems Essential in Caring for Sloths\n• Hand Warmers\n• Goats Milk\nMake a Difference for Sloths!\nYour gift goes beyond the dollars and cents of your donation. With your support, you will give orphaned, hand-raised, and rehabilitated sloths a second chance at life in the wild. It is our goal that together, every rescue call and abandoned individual found will be returned to a natural life back among the trees. Saving Sloths Together provides a future not just for the sloths who go through the program, but for the health and understanding of the species nationwide. Your donation allows us to dedicate the time, medical and expert care to one of the most charismatic species in Costa Rica, the sloth.", "label": "Yes"}
{"text": "Bougainvillea is native to South America. It is a member of the Nyctaginaceae family along with the four o'clock and the sand verbena. The plant flowers mostly in the winter and spring, but it can flower all year long.\nBougainvillea is an evergreen plant with a gnarled trunk. The flowers can be purple, lavender, carmine, scarlet, red, pink, orange, yellow and white, and can be either single or double blooms.\nBougainvillea can be grown outdoors in a hot climate. In the continental United States, that is in zones 9 and 10. Farther north, it needs to be grown in containers and brought indoors in the fall.\nBougainvillea needs full sun and soil that is a bit moist, well drained and rich in nitrogen.\nSeveral varieties of bougainvillea are used for bonsai. It can be grown as a tree, hedge, horizontally along the ground as a ground cover or in a hanging basket.\nBougainvillea can be attacked by caterpillars, aphids, scale and greenfly insects. It can also contract chlorosis because of mineral deficiencies and fungal diseases due to over watering and high humidity.\n- Bougainvillea Facts\n- Bougainvillea Information\nbougainvilleas, hanging baskets, container plants\nAbout this Author\nRegina Sass is based in the Adirondack Region of New York State. She has been a writer for 10 years writing for publications in the real estate and retail industries. Online experience includes writing,advertising and editing for an educational web site. Sass is a member of the Society of Professional Journalists.", "label": "Yes"}
{"text": "Able to be used as the coupling device for aerosolized MDI’s. By depressing the MDI, aerosolized particles are delivered into the chamber and inhaled. Gently apply the mask to one nostril and upon inhalation, the ‘Flow-Vu’ indicator will flutter toward the cat signalling inhalation.\n- Target specific lung delivery of medication.\n- Controls and alleviates airway inflammation and airway obstruction.\n- Patented ‘Flow-Vu’ indicator enables accurate counting of inhalations.\n- Exhalation valve directs the flow of air away from your cat to prevent irritation.\n- Two mask sizes to accommodate all breeds and sizes of cats.\n- Accurate directing of aerosolized pharmaceuticals to the lungs and small airways.\n- Improved drug safety and efficacy by reducing total therapeutic dose required.\n- Convenient, portable chamber.\n- Simple to use and easy to clean.\n- Reduces the risk of side effects and stresses associated with pills, syrups or injections.\nThe AeroKat Feline Aerosol Chamber is designed to be used with a metered dose inhaler (puffer or MDI) as recommended by a veterinarian to deliver aerosol medication to cats with respiratory diseases.", "label": "Yes"}
{"text": "Expression of the receptor dimer pairs. a) Schematic presentation of the constructs used in the experiments. Venus1 contains the N- terminal end of the yellow fluorescent protein variant (venus) and represents the first 157 amino acids while venus2 contains the C- terminal end of the protein and represents amino acids 158 to 238. b) HEK293 cells were harvested, washed and lysed with RIPA buffer. Samples were then run on SDS-PAGE and Western analysis was performed using indicated chaperone antibodies (1:2000). c) Specificity of GFP antibody to dimers was tested in HEK293 cells. The cells were transfected with AT1R-v1 or v2, β2AR-v1 or v2 and AT1R-v2 with β2AR-v1. 48 hours after transfection, cells were lysed in RIPA buffer. Western analysis was performed using anti-GFP (1:2000) and indicate the presence of a yellow fluorescent protein variant, venus. Results are representative of 3 independent experiments.", "label": "Yes"}
{"text": "Margaret E. Kemeny, PhD, is Professor of Psychiatry and the Director of the Graduate Academic Program in Psychology at the University of California San Francisco. After spending her undergraduate years at UC Berkeley, she received her PhD in health psychology from UCSF and completed a four-year post-doctoral fellowship in immunology at UCLA. She directs a joint PhD program in Health Psychology and Behavioral Neuroscience between the UCSF and UC Berkeley campuses.\nDr. Kemeny's research has focused on identifying the links between psychological factors, the immune system and health and illness. She has made important contributions to our understanding of the ways in which the mind -- one's thoughts and feelings -- shapes biological responses to stress and trauma.\nOver the past 15 years she has investigated the role that specific psychological responses play in predicting the course of HIV infection, as well as the immunological mediators of these effects. More recently, she has begun to focus on the inflammatory processes relevant to the course of certain autoimmune diseases. She has demonstrated, for example, that patients with more pessimistic expectations about their future health show more immune alterations and a poorer prognosis than their optimistic counterparts. This research has led to her current interest in the psychobiology of the placebo response.", "label": "Yes"}
{"text": "This is a new study indicating that some protein immediately before and immediately after a workout increase muscle growth and \"turn on\" the genes related to muscle growth.\nI've recently begun to pay more attention to proper pre and post-workout nutrition after consulting with Martin\nAcute and long-term effects of resistance exercise with or without protein ingestion on muscle hypertrophy and gene expression.\n.......Protein intake increased ........ Resistance Training -induced muscle cross-sectional area enlargement and cell-cycle kinase cdk2 mRNA expression in the vastus lateralis muscle suggesting higher proliferating cell activation response with protein supplementation. Moreover, protein intake seemed to prevent 1 h post-RE decrease in myostatin and myogenin mRNA expression but did not affect activin receptor IIb, p21, FLRG, MAFbx or MyoD expression. In conclusion, protein intake close to resistance exercise workout may alter mRNA expression in a manner advantageous for muscle hypertrophy.", "label": "Yes"}
{"text": "Byron White Formulas - A-FNG\nVendor: Byron White\nCandida, fungus and mold continue to be common infections affecting people’s health.\nA-FNG contains herbs that have been shown to support the immune system of patients dealing with all types of candida, fungus and mold. It also supports the body and contributes to regeneration. It is vital to use Support formulas with A-FNG in order to address the issues of inflammation and die-off toxicity. Detox 2 will help prevent the re-uptake of toxins and help the gut with dysbiosis so that it can heal.", "label": "Yes"}
{"text": "By clicking the below button, you agree to our terms and conditions. You will be taken to PayPal Payment page where you can fill in your credit card details and make secure payment before returning here.\nAfrica, East Africa, Global, Kenya, Tanzania Read less\nAfrica, East Africa, Global, Kenya, Tanzania Read more\nIn Kenya, Arabuko-Sokoke Forest has been estimated to support c.13,000 individuals. There are no estimates for Tanzanian populations, but the sites where the bird occurs are small, and most are very heavily degraded (N. Burgess in litt. 2007). The total population is therefore placed in the range ba ...\nThe Sokoke Pipit (Anthus sokokensis) is a species of bird in the Motacillidae family. It is found in Kenya and Tanzania. Its natural habitat is subtropical or tropical moist lowland forests. It is threatened by habitat loss. ...", "label": "Yes"}
{"text": "Most guys know it’s generally a good idea to eat healthy—even if they don’t always want to. But the fact is men have different nutritional needs depending on their age. Let’s dive into the key nutrition that guys should be getting at every age as well as some healthy tips to consider.\nIn Your 20s\nYour 20s are a great time to develop healthy eating habits that’ll last for a lifetime, like limiting processed foods and eating balanced meals of vegetables, fruit, whole grains, and lean proteins. Some key nutrients for men in their 20s are protein for developing muscle mass, calcium and vitamin D to help bones reach their peak strength, and iron to support energy and metabolism.\nIn Your 30s\nLife gets busier in your 30s, and it’s an important time to think about your energy, metabolism, and blood pressure. You should continue to eat healthy meals and cut back on starchy food, sweets, and sugary beverages. Potassium-rich foods can help lower the risk of high blood pressure. Men at this age also need more magnesium, a mineral that helps generate more energy and helps regulate blood pressure.\nIn Your 40s\nNutrient-dense and antioxidant-rich foods should be a top priority at this age. It’s important to get vitamins C and E to help defend against harmful free radicals. Make sure to eat plenty of colorful vegetables like spinach, peppers, and sweet potatoes that have high concentrations of antioxidants.\n50s and Up\nAfter age 50, it’s important for men to support their bone health. As we age, we start to lose bone mass, and bones are crucial for protecting our organs from injury. Focus on calcium-rich foods like milk, yogurt, salmon, and leafy greens. It’s also important to get vitamin D since your body can’t absorb calcium without it. Dietary fiber is another crucial nutrient as it helps support digestive health and the survival of good bacteria in the gut. So eat fiber-rich foods like whole grains, fruits, vegetables, beans, and lentils.\nFor all the guys here, let’s do what we can to stay healthy at every age. The earlier you start these good habits, the easier they’ll be to maintain.", "label": "Yes"}
{"text": "A critically endangered Sumatran elephant was found dead at a farmland in Indonesia’s Aceh province on Wednesday, and an investigation is underway to find out the cause of the death, a police officer and an official said.\nThe farmland is situated in Mila sub-district of Pidie district, the Mila sub-district police’s chief Asyari revealed.\nThe body of the male Sumatran elephant is still intact, with its ivories still existing, the police officer said.\nHe said that a herd of wild elephants often trample on farming areas, causing anxiety among the residents, local media reported.\nA team of veterinarians has been sent to the scene to investigate the cause of the death, head of the Provincial Natural Resources Conservation Center Agus Arianto said.\n“When the elephant died and what is the cause of it, we are still waiting for the result of the examination,” he said.\nHowever, the official said that the destruction of the mammal habitat could trigger conflicts with humans leaving disadvantages to both sides.\nThe Sumatran elephant is a sub-species of Asian elephant which is extremely rare at present with their number just over 2,000 based on the estimation in 2000.\nThe Sumatran elephant is found exclusively in Sumatra Island, and their population has severely edged down as they have lost more than 80 percent of their habitat due to deforestation.", "label": "Yes"}
{"text": "What is your body type? Ectomorph, mesomorph or endomorph: Ever thought, why I’m not gaining weight, even though eating and training like bodybuilders? On the other hand, some would be thinking, why I’m not able to lose weight even though taking a balanced diet, doing exercises and blah! Blah! Blah! The answer to this is that you don’t know what your body type is. Not every ‘body’ is equal. Before going to start your training and nutrition regimen, it’s important for you to understand what is your body type? Is it an ectomorph, mesomorph or endomorph? Knowing your body type will be going to help you in the long run. You can acquire the correct fitness program and diet planfor your body type, and by doing so you’ll be going to set your realistic and attainable goals.\nWho are Ectomorphs?\nEctomorph can easily be spotted by their body structure. They’re simply skinny and thin. Ectomorphs usually have small joint and lean muscles. They have long arms with stringy muscle. The shoulder is tended to be thin. Ectomorphs are also known as ‘hard gainer’. It means they find difficulty in gaining weight and building muscles.\nSome traits of an ectomorph:\n- Small body frame and bone structure.\n- Flat chest\n- Small Joints\n- Long arms and limbs\n- Fast metabolism\n- Difficulty in gaining weight\n- Difficulty in building muscles\n5 best tips for Ectomorph to gain weight\n- Eat 4–5 meals per day\nEctomorph should focus on eating 4–5 meals per day in addition with pre and post workout meals. The food works as a fuel for your body and if you’re not going to focus on fueling up your body, than you will not going to gain weight easily. Eat clean and quality foods loaded with lean protein, complex carbohydrates and healthy fats.\nDitch fast foods from your weight gaining diet plan. Fast foods won’t be going to help you in the long run. In order to gain weight, you have to surplus your calories and eating 4–5 meals per day will going to help you in adding those extra calories.\n- Eat every 2–3 hours\nEating every 2–3 hours will going to ensure that your body constantly has the fuel it requires. Suppose if you have to eat 4000 calories per day, it becomes easier by dividing your calories into 4–5 meals (500–1000 calorie per meals). Make sure to eat good quality of lean protein, complex carbohydrate and healthy fats in each meal for best results.\n- Track down those calories\nIt is necessary for Ectomorph to track down your calories if your aim is to gain weight. In order to see good results an Ectomorph must know how much calories he or she has to consume in a day. Note down each and every calorie you’re taking from your diet. Tracking calorie is a simple way to ensure you are eating enough or not.\n- Exercise less in the gym\nCommon mistake which every thin people make is that they work out every six days in a week. They thought that by hitting gym six days in a week they’ll going to build muscle fast. No, it’s not like that. Muscle is built when you eat and rest. In the gym you are actually breaking down your muscles tissues.\nAn Ectomorph should go to gym 3–4 days per week, and try to exercise for about 45–50 minutes and not more than that. When you workout, try to focus more on compound exercises rather than on isolation moves. Isolation exercises works on single muscles only but, compound exercises covers more than one muscles group. Some compound exercises are deadlift, squat, bench press, shoulder press, rows, chin-ups etc. That’s all you need to see some good results.\n- Sleep enough\nIf your aim is to gain weight or build muscle, then sleep is very much prior for you. Sleep for about 8–9 hours per night. Quality sleep is very much important for you. Body grows when it recovers and sleep is best for recovering and building muscle. During sleep your body also releases growth hormone which is very vital for muscle development. So, if your aim is to gain weight easily, then you need to find a way to incorporate this in to your routine.\nWho are Mesomorphs?\nMesomorph is the most desired body type and can also be said as ‘genetically gifted’ body. They naturally have a lean, compact and strong body. They have a lean, masculine and strong body, have medium size joints and bones. Their shoulders are wider than the hips. They are classic “gainer”. It means they tend to gain muscle fast on. But on the other way, they also gain fat fast as compared to endomorph. Mesomorph body quickly responds to exercises. Weight training can trigger their muscle gain and make them more masculine.\nSome traits of mesomorph:\n- Muscular body\n- Naturally lean\n- Strong body type\n- Shoulders are wider than hips\n- Gain muscles easily\n- Natural born athletic body\nWhat should be included in a mesomorph diet?\nIt’s been a long argument, that what should be the right proportion of nutrient component in a mesomorphic diet. But, an optimum mesomorph diet should include 50% carbohydrate, 30% protein and 20% fat. Here, one more important thing is that they gain weight more easily than other body types. So, they should have a well balanced diet and should not have focus only on a single nutritional component. They should divide their plate according to the above figures.\nMale and female mesomorph share same body characteristics but due to differ in hormones present in their body their body react differently.\nDiet plan for male\nMen should take at least 4–5 intakes in a day. If they aiming for building muscles should include high protein in their diet like: eggs, lean meat, seafood, chicken, Greek yogurt, etc. They must also include carbohydrate which repairs their muscles and fulfills energy requirements of body, some carbohydrate rich foods are: whole grain, brown bread, brown rice, oatmeal, sweet potato, etc.\nHealthy fat is also very important part of a mesomorph diet, as it helps in muscle building, retain excess fat from body and also help in curing several health problems. Some healthy fat foods are: avocado, lean meat, olive oil, cheese, etc. Avoid excess sugar as it will add fat to your body, which can lead to several health problems like obesity, diabetes, cardiovascular problems and etc.\nDiet plan for female\nFemale mesomorph should also include balance between carbohydrates, protein and fat in their diet. They should include foods high in protein and low in saturated fats. Female mesomorph should also include meat, egg, chicken, salmon and seafood’s in their diet. For complex carbohydrates they must include: brown rice, oatmeal, sweet potato, brown rice, whole grain and leafy vegetables in their diet. Sugary content should be avoided like: white bread, soda drinks, deserts, sweets, etc. mesomorph woman should include healthy fats like: nuts, fatty fish, avocado, olive oil, coconut oil.\nWho are Endomorphs?\nEndomorph can easily be figured out due to their body type. Endomorphs have a naturally chubby, round and soft physique. They have wide bone structure also have a high level of body fat. Endomorphs have a high amount of fat in their body as compared to muscles. They always have to struggle with their weight, as gaining weight is always easy for them but losing weight tends to become difficult to them as compared to other body types. Endomorphs have a slow metabolic rate in comparison with ectomorph and mesomorph.\nSome traits of an Endomorph:\n- Chubby body\n- Round and soft physique\n- Wide bone structure\n- High level of body fat\n- High fat-to-muscle ratio\n- Gain weight easily\n- Difficulty in losing weight", "label": "Yes"}
{"text": "Ficus Natasha 1.5 Meter\n1.5m tall 1m wide\nNatural wooden stem with green silk leaves set into 2 ball heads. This specific tree has very smaller leaves and the colours are an amazing light and dark green to indicate the new leaf system.\nTrees are for indoor areas and also for home or corporate use.\nTrees can be wiped down when needed.", "label": "Yes"}
{"text": "Since 1949, FAO has convened groups of experts to evaluate current scientific knowledge in order to define human energy requirements and propose dietary energy recommendations for populations. The World Health Organization joined this initiative in the early 1960s, followed by the United Nations University in 1981. New scientific knowledge generated during the 20 years since the last consultation prompted the convening of a meeting from 17 to 24 October 2001 at FAO headquarters, Rome to make recommendations for energy requirements of populations throughout the life cycle. This publication is the report of that consultation. The report is not meant merely to describe the energy expenditure and requirements of population groups but is also intended to be prescriptive in supporting and maintaining health and good nutrition, defining human energy requirements and proposing dietary energy recommendations for populations. The publication is accompanied by a CD-ROM containing a software program and an instruction manual on calculating population energy requirements and food needs.", "label": "Yes"}
{"text": "Opposite with well known view as so lots of industry experts say you really should create your muscle gradually if not you will get harm there is a secure way to build muscle mass quickly safely. Acquiring major muscle mass mass can advantage you a good deal this sort of as increased self confidence and increased self immune process. Not to mention, muscular tissues are active extra fat burners and can aid you lose pounds quick.\n1. Appropriate Diet plan\nIn buy to create muscle mass speedy the 1st matter you want to do is possessing appropriate well balanced diet on palms. Your diet plan ought to consist of a well balanced composition concerning protein, vitamin, carbohydrate, mineral, salt, fats and h2o.\nThe instance of foodstuff loaded in protein are poultry, fish, beef, pork, lamb and lean meat, it is critical to rotate your food items variety day-to-day so your physique will not get bored and this be certain high absorption fee nonetheless in location. Don’t overlook to consist of vegetables and cereals in your total diet program system, and drink a whole lot of water.\nNumerous gurus in muscle constructing will propose keeping absent from fat. Excluding body fat could assistance improve your muscle mass mass for decades, but if you want to rapidly build your muscle mass you need to include things like body fat. Consume in a pre-identified time body these types of as during breakfast and immediately after exercise routine.\n3. The Theory Of Creating Muscle\nThe theory to build muscle rapid is straightforward the energy you place into your overall body must be more than your human body usually takes to accomplish your each day activities. Consuming whey protein is one particular of the most effective means you can make guaranteed the calories you acquire often more than out.\nTake in the whey protein prior to and just after training. Before work out the whey protein will give important electricity to do exercise session. In the meantime immediately after the interval of exercise, whey protein will give you vital element to construct your muscle.\nAlso combining some of these amino acids, glutamine, and creatine can assist streamline your muscle constructing work.", "label": "Yes"}
{"text": "The group found that estren protected bone mass in both female and male mice as well as estrogen or testosterone.\nof Arkansas for Medical Sciences (UAMS) and the Central Arkansas Veterans Health Ca.\nTestosterone deficiency introduction. Testosterone is a hormone produced by the testicles and is responsible for the proper development of male sexual characteristics. Testosterone is also important for maintaining muscle bulk, adequate l.\nFor pricing and info, fill out the Quick Info Form. Optimal Health is the premier Testosterone Hormone Replacement Therapy Clinic in the United States. We are the leading Low T Doctors, Andropause Specialists and Age Management Physicians providing Human Growth Hormone (HGH) and Testosterone Treatments in Arkansas.\nLow Hgh Lynnwood Washington ‘It’s a joke,’ Washington man who raped dying teen gets less than 3 years in prison – LYNNWOOD, Wash. – A Washington state man will\nThe Arkansas Anti-Aging Treatment Center offers HGH and Testosterone Replacement Therapy for men and women suffering from Low T Symptoms due to Andropause or Menopause. Our Hormone Doctors have over 20 years of experience prescribing Testosterone Treatments and have been trained by the Mayo Clinic® and Cleveland Clinics®.\nSo end-stage renal disease muscle wasting, COPD muscle wasting, cardiac cachexia, rehab medicine, before and after hip or knee replacement.\ndo is basically a combination therapy with Lupron and whi.\nContact us to find the various Hormone Lab Testing facilities to qualify for Ant Aging, Testosterone, HGH and HCG treatments if you live throughout the state of Arkansas. At Optimal Hormone Therapy Centers, we specialize in testosterone and HGH replacement therapy.\nThe treatment typically involves testosterone replacement therapy. \"There are other medications we can use. The downside to t.\nTestosterone Therapy May Reduce Bone Loss in Older Men – MONDAY, April 7 (HealthDay News) — Injections of testosterone appear to improve bone density and reduce bone loss in older men who have low testosterone levels and may help to prevent osteoporosis, a.\nA physiologic role for testosterone in limiting estrogenic stimulation of the breast – Objective: The normal ovary produces abundant testosterone in addition.\nproliferation by blocking the AR in normal cycling monkeys and to determine whether supplementation of conventional estrogen.\nStrategies for Addressing Cancer Patients’ Complaints of Fatigue – Several instruments have been validated for use in identifying cancer-related fatigue in clinical research, such as the Brief Fatigue Inventory or the Functional Assessment of Chronic Illness Thera.\nTrt Therapy Wauwatosa Wisconsin UFC trumps Wisconsin, suspends Ben Rothwell for elevated testosterone (updated) – Rothwell, who prior to the bout received permission to undergo testosterone-replacement therapy, said the", "label": "Yes"}
{"text": "This includes the concept of “conditioned vomiting” occurring within the environment associated with delayed gastric emptying (gastroparesis). Physicians’ awareness of rumination symptoms is vital in the analysis as well as management of this disorder. Stress and also mental elements inside rumination symptoms are forever in private and also have to be addressed. The key steps in the treatment technique of rumination syndrome depend upon assurance, education and learning as well as a physiologic reason towards the individual and also family members that this is not an “disease,Inch accompanied by behaviour as well as rest applications along with addressing strain aspects.Genetics methylation is often a principal epigenetic customization controlling gene term as well as chromatin framework in several eukaryotes. Plants possess a unique Genetic make-up demethylation method in that 5-methylcytosine (5mC) is immediately eliminated through Genetics demethylases, for example DME/ROS1 family members proteins, yet little is known concerning the downstream activities. Throughout 5mC removal, DME produces 3′-phosphor-alpha, beta-unsaturated aldehyde and also 3′-phosphate by successive beta-and delta-eliminations, respectively. Your kinetic studies says these types of 3′-blocking wounds continue to persist for a significant amount of your energy and a minimum of a couple of distinct enzyme actions are needed to right away process all of them. All of us demonstrate that Arabidopsis Elp endonucleases APE1L, APE2 and also ARP have got distinct capabilities for you to procedure these kinds of harmful lesions to allow for nucleotide file format. DME term can be toxic to Protein Expression At the. coli on account of too much 5mC excision, nevertheless term of APE1L or perhaps ARP considerably decreases DME-induced cytotoxicity. Lastly, we propose one involving foundation removal restoration along with DNA demethylation process distinctive for you to plants.Target. To judge the potential effects of contest upon scientific features, level associated with ailment, along with reaction to radiation treatment in females along with postmolar low-risk gestational trophoblastic neoplasia (GTN). Approaches. This particular non-concurrent cohort examine has been carried out including sufferers with FIGO-defined postmolar low-risk GTN helped by equivalent doasage amounts as well as agendas involving chemotherapy with the Colonial Trophoblastic Disease Heart (NETDC) involving 1973 as well as 2012. National groups investigated included white wines, Dark-colored as well as Asians. Information on neuroimaging biomarkers individual traits and reaction to chemo (requirement of subsequent collection radiation, reason for altering to a different chemotherapy, variety of cycles/regimens, dependence on combination chemo, along with time to hcg diet remission) has been obtained. Outcomes. Regarding 316 girls, 274 (90.7%) have been white, 19 (6%) Black, as well as Twenty three (Several.3%) Hard anodized cookware. African People in the usa have been Sabatolimab mw considerably youthful when compared with white-colored and Asian ladies (p = 2.008). Illness display, as well as level involving disease, such as antecedent molar histology, median time for it to determination, average hcg weight loss stage from determination, charge regarding D&C with perseverance, presence of metastatic ailment, along with FIGO phase as well as risk credit score have been equivalent amongst contests.\nUpon increasing the contributor power associated with T, the particular five-coordinate more advanced gets a lot more steady compared to reactant express. Now you will find there’s mechanistic cross over to a associative (A new) process with regard to [Al(H2O)(4)L](2+)centre department of transportation Water because reactant to create a six-coordinate more advanced [Al(Normal water)(Five)L](2+)center dept of transportation Drinking water. For a lot of with the anionic ligands L Equates to * larger than NC-, – bigger than CN-, Cl-, OH- as well as — larger than SCN-) the power difference between your reactant as well as more advanced states will be tiny, in ways that the water exchange procedure is in the actual boarder involving dissociative and associative pathways. The river trade process consists of cis- as well as trans-orientated changeover states in order to create the product or service state that is comparable to the particular reactant express.Abiraterone acetate (Double a) is often a frugal inhibitor regarding cytochrom p450 (CYP) 19 which is essential for androgen biosynthesis, and will stop the particular androgens functionality by simply testicles, surrenals and also intratumoral release. In period We as well as II research inside sufferers using prostate type of cancer, remedy together with Alcoholics anonymous 250-2000 mg after day-to-day shown reductions throughout prostate specific antigen (PSA), and/or becoming more common growth cellular material Aquatic toxicology (CTCs). In two big cycle III studies throughout people with metastatic castration resilient cancer of the prostate (CRPC) inside post-docetaxel and pre-docetaxel placing, AA as well as canine prednisone in contrast to placebo in addition prednisone exhibited a tremendous superior general emergency in post-docetaxel placing, along with a superior radiological PFS inside pre-docetaxel placing. Dependent of such outcomes, Alcoholics anonymous enables throughout metastatic CRPC individuals in post-docetaxel setting or perhaps pre-docetaxel establishing The year 2013 Rocaglamide in vitro .Targets To gauge regardless of whether a water-fat permanent magnetic resonance imaging (MRI) cooling-reheating standard protocol may be accustomed to identify alterations in fat content and perfusion in the primary individual darkish adipose tissues (Baseball bat) depot from a three-hour lengthy moderate chilly publicity. Components and Methods Seven volunteers ended up investigated along with chemical-shift-encoded water-fat MRI at baseline, after having a three-hour lengthy cold publicity after subsequent small reheating. Adjustments to excess fat small percentage (FF) and R-2*, in connection with surrounding heat, have been quantified inside cervical-supraclavicular adipose muscle (viewed as suspected BAT, denoted sBAT) soon after semi-automatic division. Additionally, FF and R-2* were quantified totally instantly within subcutaneous adipose muscle (certainly not thought to be alleged Baseball bat, denoted Lay) for comparison. Through assuming various period machines for that unsafe effects of lipid return along with perfusion inside BAT, the changes ended up identified because as a result of either transformed Lab Equipment overall excess fat written content (lipid-related) or perhaps transformed absolute h2o content (perfusion-related). Outcomes sBAT-FF decreased following chilly publicity (indicate alternation in percentage factors Equals -1.4 pp, G = Zero.021) while simply no change was affecting SAT-FF (mean Is equal to 3.12 pp, S Equals 3.314). sBAT-R-2* maintained to increase (indicate Is equal to 0.\nWith Fortyfive woa, half the actual chickens have been overlaid with an FMG vaccine. Henever fatality rate, BW, egg weight, percent hen-day Air, egg blood vessels locations, as well as eggs various meats spots have been decided with a variety of cycles among 16 and also 52 woa. The data through each and every trial had been put. Treatment didn’t impact efficiency within interval My spouse and i (23 for you to Forty five woa). Nevertheless, through period of time Two (Forty-six in order to Fifty two woa), the particular EP regarding handle and also MG-Bacterin-vaccinated parrots which later acquired an FMG vaccine overlay has been under that will from the other treatment teams. Additionally, treatment application reduced hen BW during period II. Regardless of the effects about BW and also Air, simply no variations were witnessed pertaining to ovum blood vessels or perhaps meat spots one of the a variety of remedies. It is strongly recommended that this vaccination of business layers prior to lay using ts11MG, but not MG-Bacterin, may well reduce the negative has an effect on of an FMG overlay vaccine given through put. These kinds of final results establish the vaccine regarding pullets with ts11MG in conjunction with the particular vaccine of birds with the FMG overlay, with regard to continual defense towards field-strain Meters. gallisepticum infections, may be used without having curbing functionality.Nutritious polluting of the environment is really a major car owner regarding eutrophication along with unsafe algal flowers (HABs) throughout estuaries as well as coastal marine environments this website worldwide. Throughout 2011-2012,Twenty sites evenly distributed through the 251-km lengthy Native indian Water Lagoon (IRL) have been assessed during about three testing situations with regard to wiped out vitamins and minerals (DIN, SRP, Load, TDP) along with chlorophyll the. Benthic macroalgae had been also reviewed with regard to delta C-13, delta N-15, and also Chemical:N:P articles to recognize potential nutritional resources and also native immune response gauge the type and a higher level N and also S limitation. Your mean DIN and also SRP concentrations through the entire IRL were high, calculating 4.Twenty four +/- 0.Forty-five as well as 3.Sixty eight +/- Zero.06 mu Michael, correspondingly, explaining sequential immunohistochemistry the common incident regarding HABs through the review. High TDN levels (up to 152 mu M) and also TDN:TDP rates ( bigger 100:A single) in the inadequately purged north IRL, Bug Lagoon as well as Banana Lake sections shown the accumulation and also riding a bike regarding N-rich groundwater advices that produce P-limitation. These kind of fortified source of nourishment circumstances were connected with unheard of chlorophyll a levels ( bigger than 100 mu g/L), covered with Resultor sp. To. Moestrup in the Banana Water this year and also Aureoumbra lagunensis Deborah.A. Stockwell, DeYoe, Hargraves as well as P.W. Brown in the Bug Lagoon and also north IRL this year. H:D, H:P, as well as D:G proportions within macroalgae averaged 16.Being unfaithful, 698.9, as well as Forty.Half a dozen, during the entire IRL, respectively; considerably larger C:R and D:P percentages from the upper IRL sectors advised powerful P-limitation during these N-enriched oceans.\nThe particular VDM system also represents an illustration of this inter-institutional cohesiveness, merging organisations coming from a couple of various ministries, Health and The law, striving in enhancing know-how about biodiesel production the actual fatality rate within the inhabitants.Your three-dimensional flowerlike undoped and also Ho doped ZnO microstructure has been effectively created by the sonochemical technique. The actual morphologies and structures in the period ended up seen as an the examines of XRD, SEM and TEM. The particular flower-like composition composed of many one-dimensional heptagonal nanoprisms ZnO along with Ho doped ZnO have been unveiled since hexagonal gem composition along with exposure (001) aspect. The Ho doped ZnO shown a rather larger photocatalytic activity than the genuine ZnO from the destruction associated with methylene azure under Ultra violet gentle. (chemical) The year 2013 Elsevier Ltd. Most privileges earmarked.Throughout the existing examine, 138 Chlorophycean species belonging to 60 overal, Twenty five families and 9 order placed ended up recorded. The actual recorded Chlorophycean associates had been analyzed statically to the confidence restrictions. This kind of statistical examination is founded on the particular infections in IBD Chlorophycean family members from clean marine environments involving Area Swat. Series web sites were Saidu Sharif, Kanju, Aligrama, Kabal, Ningolai, Matta, Khawazakhela, Madian, Behrain along with Kalam. The boldness interval calculate is surely an interval computed from your haphazard taste regarding size in, which the amount confident we’re how the period of time retain the proportion associated with Chlorophycean categories of Region Swat.Track record: The approval involving lengthy relieve injectable naltrexone (XR-NTX; Vivitrol (Ur)) features a whole new selection for managing opioid habit, but research is necessary to discover the location from the spectrum of obtainable solutions. Having less bodily opioid dependence is a needed and demanding initial step for commencing XR-NTX. Hospital detoxing provides bad Dubermatinib order results as well as in-patient detox is actually sometimes not available as well as also simple for your physiological connection between opioids to eliminate. Here we present conclusions via a wide open label examine in which tested perhaps the move coming from opioid obsession with XR-NTX might be safely along with successfully performed in the outpatient setting making use of minimal dose naltrexone along with buprenorphine. Strategies: 20 treatment searching for opioid addicted individuals received escalating doasage amounts associated with naltrexone commencing from Zero.30 mg along with lowering amounts of buprenorphine beginning from Four milligrams after a 7-day outpatient XR-NTX induction treatment. Drawback soreness, needing, drug use, and also undesirable occasions have been evaluated daily before XR-NTX treatment, then each week within the next month. Results: Fourteen with the Twenty participants acquired XR-NTX as well as 13 accomplished each week exams. Revulsion, wanting, as well as opioid and other drug abuse had been significantly lower in the course of induction after XR-NTX supervision weighed against base line, and no critical adverse occasions ended up documented.\nThere are in past statistics considerable variations in your sliding length of the EPL muscle of all of four years old hand roles except for in which between the hand flexion and wrist Ulnar deviation situations.\nConclusions: Hand off shoot brings about the greatest degree EPL tendons gliding.Track record: Chemokines play essential roles in cancer malignancy growth and advancement. Epithelial-derived neutrophil-activating peptide-78 (ENA78/CXCL5) and also stromal cell-derived issue (SDF-1/CXCL12) allegedly give rise to gastric most cancers (GC) improvement and development. This study aspires to evaluate serum amounts of ENA78/CXCL5 and SDF-1/CXCL12 across the GC carcinogenesis, and also examine his or her clinical value, and diagnostic possibilities through human serum examples. Techniques: A total of More than 200 subjects had been participating in this study. Solution numbers of ENA78/CXCL5 along with SDF-1/CXCL12, tested simply by chemiluminescent immunoassay, ended up in comparison among Some illness teams; regular, high-risk (intestinal metaplasia and also adenoma), first GC (EGC), as well as advanced GC (AGC) groups in coaching (in Equals Twenty-five for each team) as well as approval dataset (d Equals 70, 40, Fifty, Fifty, correspondingly) simply by ANOVA test (post hoc Bonferroni). Correlations between serum ENA78/CXCL5 or even SDF-1/CXCL12 quantities as well as clinicopathological parameters associated with GC patients were evaluated (Spearman’s relationship; gamma(azines)). In order to authenticate the actual analytic accuracy, recipient functioning trait (ROC) necessities along with logistic regression investigation was performed. Final results: Serum ENA78/CXCL5 and also SDF-1/CXCL12 levels were significantly larger in AGC teams compared to EGC, high-risk along with regular groups in training and also validation dataset (Bonferroni, from p smaller than Zero.02 to be able to g smaller compared to Zero.001). Clinicopathologically, serum ENA78/CXCL5 had been correlated together with T-stage (gamma(utes) Equates to 2.231, s = 3.021) and remote metastasis (gamma(azines)Equates to 0.357, s smaller when compared with Zero.001), while solution SDF-1/CXCL12 was associated along with lymph node (gamma(ersus) =0.220, s = 0.029) along with far-away (gamma(s) =0.425, g smaller when compared with Zero.001) metastasis. ROC curve and also medial rotating knee logistic regression revealed that solution ENA78/CXCL5 as well as SDF-1/CXCL12 showed higher diagnostic exactness in comparison with carcinoembryonic antigen (CEA) within forecasting GC. Solution ENA78/CXCL5 may predict both the medical endoscope existence of GC along with remote metastasis, even though solution SDF-1/CXCL12 might mainly predict their faraway metastasis. Almost all blend of solution ENA78/CXCL5, SDF-1/CXCL12, and also CEA accomplished Ninety two.8% uniqueness at Seventy five.0% sensitivity to calculate remote metastasis of GC. A conclusion: Combinations of first solution ENA78/CXCL5, SDF-1/CXCL12, and also CEA before virtually any selleck kinase inhibitor strategy to GC can create useful solution biomarker panels to predict the reputation along with distant metastasis regarding GC. (d) 2015 Elsevier Ltd. Almost all protection under the law set-aside.Necrosis performs a vital role in a number of biological along with pathological processes. Lately, a relatively brand new form of necrosis continues to be characterized as “necroptosis”. Morphologically, necroptosis reveals the options involving necrosis; nonetheless, necroptosis demonstrates a unique signaling path that needs the actual participation associated with receptor connection health proteins kinase One and three (RIP1 and RIP3) and is especially inhibited simply by necrostatins. Necroptosis has been discovered for you to help with your regulation of disease fighting capability, cancers development and also cellular answers to numerous stresses.\nP. aeruginosa reactions to the telltale conditions have been looked at Zoledronate employing colony morphotype, biochemical as well as enzymatic characterisation, pyocin keying, serotyping, level of sensitivity to several lessons involving anti-biotics as well as molecular recognition. Final results show hunger in normal water microcosms result in unconventional phenotypes. Of great interest is the pyocin transformed via 24/n in the wild sort in order to 83/a right after way of life in the water microcosms, along with the serotype altered through O6 inside the untamed variety to O1 throughout microcosm-cultured G. aeruginosa. Additionally, the actual starvation interval in various aquatic microcosms increased the level of resistance of S. aeruginosa in opposition to beta-lactam anti-biotics. When compared to other aquatic conditions, the particular sea water microcosm produced the highest volume of variants throughout S. aeruginosa. Overall, information demonstrated a high suppleness involving R. aeruginosa to ecological changes. This could describe the bizarre antibiotic-resistant phenotypes of P. aeruginosa species, in addition to their capacity for dispersing that leads for you to human being attacks.This particular paper research structurel attributes with the optimal useful resource part policy for single-queue techniques. Work opportunities go to a service ability and so are delivered one at a time into a swimming associated with calculating helpful similar running. The facility poses a new restriction on the greatest estimated sojourn use of a job. A main selection manufacturer allocates the computers dynamically on the ability. All of us contemplate a couple of versions: a limited General psychopathology factor resource allocation design, in which the percentage of means is only able to end up being transformed at the outset of a new service, and a completely versatile percentage model, where the allocation involving sources may also change within a assistance period. Of these a pair of models, the objective is always to reduce the average utilization charges while satisfying the time restriction. As a consequence, all of us cast these optimization problems Prebiotic synthesis as Markov selection issues along with gain structurel properties in the relative price function. We demonstrate via vibrant encoding in which (A single) the perfect allocation insurance plan has a work-conservation home, and also (A couple of) the optimal variety of machines employs a stride purpose together with as excessive policy the actual bang-bang manage insurance plan. Moreover, (Several) our company offers circumstances that the particular bang-bang handle coverage happens. These types of properties give a total characterization with the ideal insurance plan, that are illustrated simply by statistical findings.With an adequate treatments arranging and also holding of people together with told apart hypothyroid cancer malignancy (DTC), the right project associated with thyroid remains (TRs) along with lymph node metastases (LMs) is vital. Individuals, method: We retrospectively assessed regardless of whether kinetic volumes will help improving Ulti-level marketing task employing successive I-124-PET/CT data.\nThis strategy in order to widening the associated with legitimate safety of the substance utilized as the APS is not appropriate sometimes from your medical or perhaps from the honourable opinions. Our own x-ray diffraction review of abacavir sulfate (USP Urs) demonstrated that this substance as well as abacavir hemisulfate is the same, judging by published files for the framework regarding abacavir hemisulfate deposits. Each one of these elements is really a fairly neutral sea with each having the particular fischer method (C14H19N6O)(Two)SO4 as well as a molecular fat regarding 670.Seventy-six. Therefore, repatenting a recognized APS (i.elizabeth., abacavir sulfate) being a brand new material within title wrong for the natural salt, my partner and i.electronic., (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-methanol hemisulfate, is actually unjustified.Submandibular as well as parotid salivary glands obtain long ductwork since they travel throughout advancement. Zero definite accounts exist in scientifically important biological normal variants and also morphometry from the submandibular air duct regarding Wharton along with the parotid air duct regarding Stenson. All of us retrospectively examined 67 typical NN2211 clinical trial electronic digital subtraction sialograms about individuals ranging from Sixteen to Eighty five years old (Meters:P oker = Fifteen:Fifty-two). Throughout Forty three sialograms, the particular indicate parotid duct length has been 60 millimeter. The mean width with the proximal, middle of the, and distal portions with the parotid duct were One particular.8-10 mm, A single.One millimeter, along with Bioactive cement A single.Six millimeters, correspondingly. An adjunct parotid glandular was contained in 68% of individuals, using a indicate perspective associated with confluence of their tributary duct using the parotid duct regarding Fifty three degrees. Throughout All day and sialograms your mean length of the submandibular air duct has been 59 millimeters. The actual imply thickness of the proximal, core, and also distal sections with the submandibular duct ended up 2.Zero millimeters, Only two.Several millimeters, and 2.A single mm, correspondingly Oil remediation . The actual submandibular duct genu were built with a imply perspective associated with 115 levels. The effect involving impartial specifics (get older, sex, along with aspect) ended up being statistically analyzed about the centered variables (period, mean calibre, and perspective) making use of regression examination. Not one of the unbiased specifics impacted versions in total, dimension and angulation. These kinds of noted comprehensive along with comprehensive morphometrics are of help for beneficial arranging regarding luminal processes about the salivary ductwork, which includes sialography, sialoendoscopy, interventional treatments, and lithotripsy. (d) Next year Created by Elsevier GmbH.The actual prion necessary protein (PrP)-known because of its main role inside transmissible spongiform encephalopathies-has already been documented to own two nuclear localization signals as well as localize from the nuclei involving certain cells in numerous forms. Although these kinds of information are generally superficially contradicting, it can be apparent that will nuclear varieties of the prion necessary protein come in cellular material in either the balanced or infected state. Take a look at report that Shadoo (Sho)-a part of the particular prion necessary protein superfamily-is furthermore found in the nucleus of several neural and also non-neural cell collections because imagined while on an YFP-Sho build.\nNo this sort of consistent collection regarding locations corresponding to AICPMIP’s chosen A 1 zone ended up being, even so, noticed. Depending on the discriminating ability, originality, along with investigation resources, 12 areas were defined as important examination places pertaining to examination through the 2 mega-environments. Testing with these places gave the impression to provide excellent insurance coverage of the complete treasure millet growing parts of Indian. Determined by these bits of information, experts recommend to be able to execute original produce studies from identified 12 locations around all of the treasure millet expanding areas symbolized by simply 2 mega-environments accompanied by tests of picked check details eco friendly with particular variation of their respected version areas and specific zones.Context: Brain Iron Deposits ( IDs) are usually linked to neurodegenerative conditions and also reduced mental operate throughout after lifestyle, however trigger is unknown. Dog reports have located proof of connections in between nutritional iron, fat and also cholesterol intake as well as mind flat iron build up. Objectives: To analyze their bond involving iron, gram calorie, and also ldl cholesterol consumption, bloodstream signals involving metal reputation, as well as mental faculties IDs in people. Style, Placing and Individuals: Cohort regarding 1063 community-dwelling elderly folks delivered inside 1936 ( indicate Community-associated infection age Seventy two.7years, SD=0.Seven) using dietary information, results from blood sample looks at and also mind image information contemporaneously inside later years. Proportions: Magnetic Resonance Photo was utilized to gauge regional quantities of human brain IDs throughout basal ganglia, brainstem, bright matter, thalamus, as well as cortex/border with the corticomedullary jct, by using a completely programmed assessment treatment accompanied by person checking/correction in which needed. Haemoglobin, red cellular count, haematocrit, suggest mobile or portable quantity, ferritin as well as transferrin have been obtained from blood samples as well as common T‑cell-mediated dermatoses daily utilization of metal, energy, and ldl cholesterol have been determined from your confirmed food-frequency set of questions. Results: Overall, 48.8% of the trial that have appropriate MRI ( n=676) acquired mental faculties IDs. Your mean full amount of IDs has been 40mm3, inter-quartile array ( IQR)=196. Basal ganglia IDs ( median=35, IQR=159.5 mm3), put together throughout 80.6% from the trial. IDs in the brainstem were found within 14.9% of the taste, from the cortex in One particular.9%, from the white make a difference inside Six.1% along with the thalamus in A single.0%. The particular mean daily use of energy ended up being 1808.5kcal ( IQR=738.Five), involving cholestrerol levels was 258.5mg ( IQR=126.Two) and also overall straightener ended up being 12.7mg ( IQR=5). Metal, caloric or even cholestrerol levels consumption just weren’t right associated with brain IDs. Nonetheless, calorie intake had been associated with ferritin, the metal safe-keeping proteins ( p=0.09). Bottom line: The results advise that general calorie, metal and also cholesterol ingestion usually are not associated with IDs within minds regarding healthy old folks nevertheless calories could be associated with straightener storage.\nTherefore we pondered that ZL-n-91 might have stronger restorative risk of management of inflamation related thoracic oncology condition when compared with rolipram, moment have more robust nerves impact as compared to rolipram. (C) The year of 2010 Elsevier T.Sixth is v. Just about all rights set-aside.This research infections in IBD characterized pharmacologically the functional answers to be able to agonists angiotensin The second (AngII) and also bradykinin (BK) derivatives that contain check details the particular TOAC (2,2,6,6-tetramethylpiperidine-Noxyl-4-amino-4-carboxylic acidity) spin and rewrite [abet at the N-terminal (TOAC(One particular)-AngII along with TOAC(3)-BK) and inside (TOAC(Several)-AngII as well as TOAC(Three)-BK) positions of such vasoactive peptides. Thanks constants of the ligands with regard to From(One) and B-2 receptors had been examined in vitro through binding assays and also organic outcomes through extracellular acidification costs as well as in vivo simply by blood pressure answers. Not like inside the camera marked analogues (TOAC(Three or more)-AngII or perhaps TOAC(Three or more)-BK), your TOAC(One)-AngII and TOAC(Zero)-BK derivatives dose-dependently elevated your extracellular acidification charge throughout adherent classy Oriental hamster ovary (CHO) cellular material revealing AT, or even B2 receptors, correspondingly. In addition, TOAC(1)-AngII activated a rise in blood pressure whenever inserted intravenously in awaken test subjects but with a new potency 4 times scaled-down in comparison with local AngII. Much like BK, TOAC(2)-BK dose-dependently lowered hypertension while inserted intra-arterially throughout rats which has a reduce effectiveness as compared to the native peptide. On the other hand, TOAC(Three)-AngII as well as TOAC(Three)-BK didn’t provoke virtually any change throughout blood pressure levels. To sum up, our outcomes validated how the installation of TOAC-probe within the N-terminal area involving proteins will not drastically get a new appreciation or even neurological task throughout vitro as well as in vivo circumstances and could be a significant toool to gauge peptide-receptor discussion device. Alternatively, perhaps because of the unique bend-inducing property in the cyclic TOAC probe, its attachment at position 3 in the AngII along with BK constructions usually minimize your conversation and the account activation with the From, and also B2 receptors. (d) 07 Elsevier W./. All legal rights set aside.In every eukaryotes, the specific enzyme, RNA polymerase My partner and i (Pol I), is dedicated to be able to write out your 35S rRNA gene from the multicopy gene group, your ribosomal Genetic make-up (rDNA). In certain Saccharomyces cerevisiae mutants, 35S rRNA genes may be transcribed by RNA polymerase 2 (Pol II). Of these mutants, rDNA silencing of Pol The second transcribing can be disadvantaged. It’s been pondered which upstream causing issue (UAF), which in turn adheres to a particular Genetic aspect inside Pol My spouse and i marketer, takes on an important role in forming chromatin houses in charge of polymerase nature and also silencing with the rDNA locus. We as a result done an in-depth evaluation associated with chromatin composition as well as composition in several mutant backdrops. We all show chromatin structure with the total Pol I-transcribed place will be substantially modified even without the UAF, enabling RNA polymerases Two along with Three gain access to Genetic make-up aspects flanking the Pol promoter-proximal Reb1 presenting website. In addition, not enough UAF leads to losing Sir2 from rDNA, correlating with impaired Pol 2 silencing. This analysis involving rDNA chromatin supplies a molecular foundation, explaining many phenotypes affecting prior hereditary analyses.\nMany of us targeted to formulate a new mobile or portable way of life type of diabetes type 2 symptoms by simply the treatment of SK-Hep-1 cells together with four totally free fatty acids [i.at the., palmitic chemical p, stearic chemical p (SA), linoleic acid solution and oleic acid]. The final results established that Akt phosphorylation ended up being increased throughout SK-Hep-1 cellular material given insulin in the time- along with concentration-dependent fashion, which has been limited by soaked fatty acids, and not simply by unsaturated fat. Moreover, necessary protein degrees of NADPH oxidase (NOX) Some however, not NOX2 were improved right after SA treatment and also, consequently, increased reactive fresh air types generation along with decreased mobile glutathione were noticed. Apocynin, the NOX4 chemical, renewed the SA-induced inhibition associated with Akt phosphorylation, advising horizontal histopathology the function involving NOX4 in insulin level of resistance caused by SA. None phosphorylation amount neither necessary protein level of the load signaling kinases, such as c-Jun N-terminal kinase as well as p38 mitogen initialized protein kinase, was altered through SA therapy. Though presenting immunoglobulin protein, a new gun involving endoplasmic reticulum tension, had been transiently greater in SKHep-1 tissue addressed with SA, 4-phenyl butyric acidity, a compound chaperone, did not have any influence on your insulin-mediated Akt phosphorylation restricted through SA. The actual examine gives a valuable style for verification anti-insulin resistance medicines and also finding fresh drug targets for treatment of diabetic issues. (Chemical) 2013 Elsevier Ltd. Almost all rights set aside.Merely five varieties are the cause of 92% regarding instances of candidemia (Vaginal yeast infections, H.glabrata, Chemical.tropicalis, C.parapsilosis, and D.krusei); nonetheless, their particular submission may differ within population-based studies carried out in numerous Response biomarkers regional locations. Chemical.albicans is regarded as the frequent varieties, yet significant distinctions are located between the number of cases due to Chemical.glabrata and Chemical.parapsilosis. Studies coming from Upper The european countries as well as the United states of america noted a top number of cases a result of C.glabrata, while studies through Italy and also Brazilian demonstrated less number of instances caused by D.glabrata as well as a larger number of instances due to D.parapsilosis. Globally, how often of Chemical.albicans can be lowering, while that regarding H.glabrata as well as Chemical.krusei is dependable, as well as H.parapsilosis along with Chemical.tropicalis tend to be escalating. Affected person qualities as well as earlier antifungal remedy possess a significant influence on your submission and rate of recurrence involving Yeast spp., no matter the regional region. D.albicans is a bit more regular throughout people older up to 18years, how often involving C.parapsilosis decreases as we grow older, and also H.glabrata is a lot more frequent within the seniors. Last but not least, the presence of horizontally transmission regarding this website Yeast infection spp. isolates (documented primarily inside sufferers from the grown-up health care as well as post-surgical ICU, sufferers from oncology-haematology products, and also neonates) may affect types submitting.Despite the fact that associative recollection research create a great number of false recollections, neuroimaging analyses employing this model generally target just upon neurological activity mediating productive access.", "label": "Yes"}
{"text": "Table of Contents\nCan geraniums survive 40 degrees?\nAccording to Protabase, geraniums grow well in the temperature range of 65 to 95 degrees F during the growing season, and in the winter low temperatures between 40 to 50 degrees F, according to the \"A-Z Encyclopedia of Garden Plants.\" via\nCan geraniums survive 45 degrees?\nIndoor Geraniums and Temperature\nThe ideal temperature for growing geraniums indoors is 65 to 70 F during the day and 55 F at night. If you bring your pots indoors after the temperature drops below 45 F, the warmth may shock them, turning their leaves yellow and causing them to drop. via\nWhat temp can geraniums tolerate?\nGeraniums prefer cool indoor temperatures. Daytime temperatures of 65 to 70 degrees Fahrenheit and slightly cooler night temperatures are ideal. During their stay indoors, water the plants thoroughly when the soil becomes dry. via\nCan geranium survive frost?\nGeraniums, one of my favorite container plants, cannot tolerate a freeze, according to the University of Florida. But they can tolerate a light frost if they have had a chance to adjust to cool temperatures. via\nHow do I protect my geraniums from frost?\nDig up the plants before the first frosts arrive and shake all the soil off the roots. Tie a small bunch of the plants together and suspend them upside down from the roof of the garage. Dust lightly with fungicidal powder such as sulphur and leave them until the spring. via\nWhat temperature is too cold for impatiens?\nAlthough impatiens thrive in Mediterranean climates, they typically prefer shaded temperatures of around 65 to 70 degrees Fahrenheit. Impatiens may die if the thermometer dips below 32 F. via\nDo geraniums like full sun?\nGeraniums are a sun loving plant that need 4-6 hours of full sun a day, or perhaps longer in somewhat filtered light. South and west exposures are usually best. via\nWhen should I bring my geraniums inside?\nTo overwinter geraniums, bring them indoors prior to frost. If you are growing them in a tub or container and time is at a premium (as it usually is in fall), simply drag the entire pot indoors where they should keep for a few weeks while you tend to other more pressing garden chores. via\nHow do you bring geraniums back to life?\nCan I leave geraniums in the ground over winter?\nStoring geraniums for winter is super easy — you just put them in a cardboard box or a paper bag and close the top. Here are some tips to improve their survival: Keep your geraniums in a cool, dry location, at about 50 to 60 degrees F. Check for mold about once a month and remove dried leaves from the bag or box. via\nWhat month do you plant geraniums?\nPlant out only once all danger of frost has passed, usually from late May. If growing geraniums as house plants, you can let the plant carry on flowering into autumn, even winter. via\nCan I put my geraniums outside now?\nTropical plants should remain in their winter storage until temperatures no longer fall below 10 ° C. Balcony beauties such as Geraniums, Fuchsias, or Angel's Trumpet should remain protected, as well, until mid-May. via\nHow much frost can geraniums stand?\nKeeping Geraniums Alive\nLike petunias, geraniums — potentially perennials in USDA zones 9 through 11 — are likely to come through a light frost unscathed. Those with thick stems probably will survive a moderate freeze, with temperatures from 25 to 28 F, though it is likely to shrivel their flowers and leaves. via\nAre geraniums winter hardy?\nTrue geraniums, on the other hand, are much more cold hardy and can be grown as perennials in many more climates. Most are winter hardy in USDA zones 5 through 8. Certain varieties can survive the hotter summers in zone 9, and some others can survive, at least as far as the roots, in winters as cold as those in zone 3. via\nCan petunias survive a frost?\nMany newer cultivars are able to withstand hotter temperatures, but no petunias thrive in chilly temperatures. When spring temperatures dip below 40 degrees F, either cover your outdoor petunias with frost cloth or bring them indoors. Temperatures below freezing will kill them in a jiffy. via", "label": "Yes"}
{"text": "ZIMBABWE made great medical strides containing the COVID-19 pandemic, through a rigid and disciplined vaccination campaign during 2021 and 2022.\nToday, however, a new virus, in the form of monkeypox virus, has recently emerged to threaten the world. Is Zimbabwe prepared for it?\nWith the eradication of smallpox in 1980 and subsequent cessation of smallpox vaccination, monkeypox virus emerged as the most important orthopoxvirus for public health.\nThis viral zoonosis disease – i.e.: a virus transmitted to humans from animals, has clinical symptoms similar to those seen in smallpox patients although it is clinically less severe.\nSmallpox is a related orthopoxvirus infection which has been eradicated.\nAccording to the World Health Organisation (WHO) – “Smallpox was more easily transmitted and more often fatal as about 30 percent of patients died. The last case of naturally acquired smallpox occurred in 1977, and in 1980 smallpox was declared to have been eradicated worldwide after a global campaign of vaccination and containment.” It has been 40 or more years since all countries ceased routine smallpox vaccination with vaccinia-based vaccines.\nIn the past monkeypox occurred primarily in Central and West Africa, often in proximity to tropical rainforests, but increasingly recently has been appearing in urban areas.\nThe disease is called monkeypox because it was first identified in colonies of monkeys kept for research in 1958.\nIt was only later detected in humans in 1970.\nWhat emerged as an exclusive tropical disease, In recent times, monkeypox has emerged globally as a lethal viral zoonosis\nMonkeypox virus is an enveloped double-stranded DNA virus that belongs to the orthopoxvirus genus of the poxviridae family.\nAnimal hosts include a range of rodents and non-human primates.\nTo date however, uncertainty remains on the natural history of monkeypox virus and further studies are needed to identify the exact reservoir(s) and how virus circulation is maintained in nature.\nStudies are currently underway to further understand the epidemiology, sources of infection, and transmission patterns.\nHuman monkeypox was first identified in humans in 1970, in the Democratic Republic of the Congo (DRC), in a nine-month-old boy in a region where smallpox had been eliminated in 1968.\nSince then, most cases have been reported from rural, rainforest regions of the Congo Basin, particularly in the DRC and human cases have since been reported increasingly from across Central and West Africa.\nThe Congo Basin clade in Central Africa has historically caused more severe disease and was thought to be more transmissible. The geographical division between the Central and West Africa clades has so far been in Cameroon, the only country where both virus clades have been found.\nSince 1970, human cases of monkeypox have been reported in eleven African countries namely: Benin, Cameroon, the Central African Republic (CAR), DRC, Gabon, Cote d’Ivoire, Liberia, Nigeria, the Republic of the Congo, Sierra Leone and South Sudan.\nSome of these countries only had a few cases and others have had persistent or recurrent outbreaks.\nMonkeypox is now a disease of global public health importance as it not only affects countries in West and Central Africa, but the rest of the world.\nIn 2003, the first monkeypox outbreak outside of Africa was in the USA. It was linked to contact with infected pet prairie dogs that had been housed with Gambian pouched rats and dormice imported into that country from Ghana.\nThis outbreak led to over 70 cases of monkeypox in the United States.\nIn September 2018, monkeypox was reported in travelers from Nigeria to Israel; travelers to the United Kingdom in September 2018, December 2019, May 2021 and May 2022; travelers to Singapore in May 2019 and to the United States of America in July and November 2021.\nIn May 2022, multiple cases of monkeypox were identified in several non-endemic countries.\nHowever, the identification in May 2022 of clusters of monkeypox cases in several non-endemic countries with no direct travel links to an endemic area was atypical. The recent outbreak affecting many countries at once was not typical of previous outbreaks .\nFurther investigations were underway to determine the likely source of infection and limit further onward spread.\nAnimal-to-human (zoonotic) transmission can occur from direct contact with the blood, bodily fluids, or cutaneous or mucosal lesions of infected animals.\nThe natural reservoir of monkeypox has not yet been identified, though rodents are the most likely suspects.\nEvidence of monkeypox virus infection in Africa, has been found in many animals including rope squirrels, tree squirrels, Gambian pouched rats, dormice, different species of monkeys and others. Eating inadequately cooked meat and other animal products of infected animals is a possible risk factor and should be guarded against.\nJust as the devastating COVID-19, human-to-human transmission can result from close contact with respiratory secretions, skin lesions of an infected person or recently contaminated objects. Transmission via droplet respiratory particles usually requires prolonged face-to-face contact, which puts health workers, household members and other close contacts of active cases at greater risk.\nWhile close physical contact is a well-known risk factor for transmission, it is unclear at this time if monkeypox can be transmitted specifically through sexual transmission routes.\nTransmission can also occur via the placenta from mother to fetus (which can lead to congenital monkeypox) or during close contact during and after birth.\nOver time, most human infections have resulted from a primary, animal-to-human transmission.\nIn order to reduce the risk of zoonotic virus transmission, unprotected contact with wild animals, especially those that are sick or dead, including their meat, blood and other parts must be avoided. Additionally, all foods containing animal meat or parts must be thoroughly cooked before eating.\nSome countries have put in place regulations restricting importation of rodents and non-human primates.\nCaptive animals that are potentially infected with monkeypox should be isolated from other animals and placed into immediate quarantine.\nAny animals that might have come into contact with an infected animal should be quarantined, handled with standard precautions and observed for monkeypox symptoms for 30 days.\nThe incubation period – i.e.: the interval from infection to onset of symptoms of monkeypox is usually from six-13 days but can range from five-21 days with the symptoms lasting from two-to-four weeks; the invasion period lasts between zero–five days. It is characterised by fever, lymphadenopathy (swelling of the lymph nodes), intense headache, back pain, myalgia (muscle aches) and intense asthenia (lack of energy).\nSkin eruption usually begins within one– three days of the appearance of fever.\nIn severe cases, lesions (filled with clear fluid and pustules filled with yellowish fluid), can coalesce until large sections of skin slough off. The rash tends to be more concentrated on the face and extremities rather than on the body.\nAlso affected are oral mucous membranes, genitalia and conjunctivae (20 percent), as well as the cornea. Complications of monkeypox can include secondary infections, bronchopneumonia, sepsis, encephalitis, and infection of the cornea with ensuing loss of vision. The extent to which asymptomatic infection may occur is unknown.\nSevere cases of monkeypox are more common among children and are related to the extent of virus exposure, patient health status and nature of complications.\nUnderlying immune deficiencies may lead to worse outcomes.\nAlthough vaccination against smallpox was protective in the past, according to the WHO, persons younger than 40 to 50 years of age, depending on the country’s health status, may be more susceptible to monkeypox today due to cessation of smallpox vaccination campaigns after the global eradication of the disease announced in 1980.\nDr Tony M. Monda BSc, DVM, is currently conducting veterinary epidemiology, Agronomy and Food Security and Agro-economic research in Zimbabwe. E-mail: firstname.lastname@example.org", "label": "Yes"}
{"text": "Wildlife photography of the new forest, 80 degrees north and further afield\nFirst of all a very warm welcome to the website.\nThe New Forest Gallery is one of the larger collections of images to be found here and it is the local wildlife especially that most recognisable of British mammals, the Badger.\nHowever it is the varied wildlife and landscapes of the Fennoscandinavian countries that hold a very special interest. In particular the large predators of Finland and the high Arctic in and around the Svalbard archipelago that keep drawing me back time and again along with the fantastic light that these parts of the world are mostly blessed with ……… a photographers dream.\nAll images are of purely wild animals found in their natural habitats, some of these habitats are in the more remote parts of the world.\nConversely a few red deer images were taken in Richmond Park in Surrey and consequently have become somewhat habituated.\nI do hope you enjoy browsing the various galleries and thank you for visiting.", "label": "Yes"}
{"text": "The islands of Malta are fabled for their honey. In fact, the name “Malta” is derived from the ancient Greek word Melitē, or honey-sweet.\nThe art of keeping honey bees has been around for at least 8,500 years.\nIt is believed to have been introduced to the islands of Malta by the seafaring Phoenicians in 750 BCE.\nTo better understand the allure and mystique of Maltese honey, Tricia and I met with Michael Muscat, a local beekeeper who produces raw honey in limited quantities.\nWe met Michael at a Christmas market in Malta’s capital of Valletta. Here, we purchased a jar of his honey.\nThis honey was extraordinary. It had a dark red color unlike any honey I’ve ever seen. The color was a result of his bees visiting the blossoms of carob trees in the autumn.\nWe began inundating him with questions.\nSensing our enthusiasm to learn more, Michael agreed to give us a tour of one of his 6 apiaries. However, at the time, Malta had had the driest winter in 93 years.\nThis was especially hard on the bees and their search for flower nectar. As a result, the year’s honey production was significantly diminished.\nMy Video of The Experience\nHave a look at our visit to Michael’s apiary:\nWhat is Raw Honey?\nRaw honey is defined as honey that has not been heated past the temperature in the beehive, or 35ºC (95ºF).\nRaw honey has a long history of being used to enhance cuisine. However, it also has a number of positive health properties, including:\nIt is also thought to boost immune systems.\nRaw honey is not pasteurized and is generally unfiltered. These processes remove the naturally occurring pollen.\nPollen is essential for determining the source of the honey.\nIncreasing Global Demand\nUsing pollen to recognize where honey is produced is increasingly important in a globalized food chain. Harmful pesticides are unfortunately making their way into our kitchens.\nThe European Union has been exceptionally stringent in its regulation of pesticides. The governing body applies the precautionary principle, a philosophy of thoroughly testing a chemical before introducing it to the environment.\nThis high level of caution has been critically important for beekeepers.\nSeveral poisonous neonicotinoid pesticides have been banned in Europe due to the danger they pose to bees.\nRoughly one third of our agricultural products are dependent upon healthy and happy bees. Therefore, the careful and sparing use of pesticides makes sense.\nRaw Honey and Tourism\nBees are essential to fruit, vegetable, and nut production. However, they are also an increasing source of tourism revenue.\nSlovenia, a lush green country on the northeastern corner of the Adriatic Sea, has taken the lead in promoting the burgeoning field of bee tourism.\nSlovenia offers honey massages, honey spas, and honey therapy.\nA Maltese Opportunity\nConsidering their namesake, the islands of Malta should be a pioneer in the field of bee tourism.\nHowever, in order to capitalize on this opportunity, the Maltese must begin placing a premium on the country’s green space.\nRampant development threatens to strip the small islands of any land where flowers can bloom.\nCarob Honey Dreams\nThe jar of dark red honey that Tricia and I bought from Michael Muscat in December was the most delicious honey I’ve ever tasted. I still dream about it.\nI would often drizzle it over a hot bowl of oatmeal. However, I’m sure it would have gone well with nearly anything, including buttery toast or swirled in a hot cup of tea.\nGrab a Jar\nMalta has three different seasonal varieties of honey. If you visit the islands, see if you can try them all.\nIf you can, also purchase a jar. The increasing demand for Maltese honey will help place a premium on the country’s green space. That is great for everyone — especially the bees.", "label": "Yes"}
{"text": "Hydrocephalus results from abnormal cerebrospinal fluid (CSF) volumes or flow patterns. The absorption of CSF is determined largely by pressures within veins and venous sinuses in the head and adjacent to the spine. Most surgical solutions for hydrocephalus involve diversion of excess CSF into alternative absorption sites, and most of these solutions are still suboptimal. The focus of this work has been to recreate more normal CSF absorption into the dural venous sinuses without having to directly access the superior sagittal sinus (SSS).\nIntraosseous skull infusion for the purpose of accessing the SSS and the systemic venous system was tested by experimental skull infusions of tracer fluids into living large animals (14 adult pigs).\nCompared with control injections into an ear vein, infusions into the skull through specially designed infusion devices had similar systemic absorption characteristics. This suggested that intraosseous skull infusion in a living large animal was successful in gaining access to the SSS and systemic venous system.\nThis study constitutes the first demonstration of the success of intraosseous skull infusion in gaining rapid access to the systemic venous system and it thus opens the possibility of using this strategy for diversion of CSF back into the intracranial venous system for the treatment of hydrocephalus.", "label": "Yes"}
{"text": "We studied age and size dependence of pumping and respiration rates, mortality during prolonged air exposure and the changes in behavioural response to cyclic salinity fluctuations combined with elevated temperatures in the White Sea blue mussels Mytilus edulis L. Five age groups (2-9 years) and three size groups: small (S, mean wet tissue mass 0.12 g), medium (M, mean wet tissue mass 0.39 g) and large (L, mean wet tissue mass 0.78 g) were analysed. Respiration rate was measured in closed respirometers. Pumping rate was determined by a laser beam to monitor the changes in water level when the inhalant and exhalant siphons were in separate compartments of the aquarium. To study their response to environmental stress, the mussels were subjected to cyclic salinity fluctuations at normal (10°C) and elevated (20°C) temperatures. Two parameters were noted: (1) the salinity at which shell valves either opened or closed at both temperatures, and (2) intra-individual variation of the behavioural response to salinity changes at both temperatures. Size and age affect physiological processes in the blue mussel. The responses of M. edulis to environmental stress including low salinity, elevated temperature and air exposure as well as respiration rate are generally size-dependent. Effects of age on sensitivity to low salinity and survival in air are minor. Pumping rates of mussels are significantly affected by both size and age of the animals. The disproportional decrease of pumping rate is observed at the age of about 7-8 years old.\n|Журнал||Journal of Experimental Marine Biology and Ecology|\n|Состояние||Опубликовано - 29 янв 2003|\nПредметные области Scopus\n- Экология, эволюция поведение и систематика", "label": "Yes"}
{"text": "Record a Sighting\nUpload a Photo\n(100 per page)\nYou can copy-and-paste this URL to anywhere else on the web:\n26 Jan 2015\nMost plants of this subspecies had finished flowering st this time. This was the only plant found with reasonable flowers remaining. This grows alongside subsp. eglandulosa which was in the peak of its flowering time.", "label": "Yes"}
{"text": "The Implementation of Paired Descriptor Functions to Improve Quantitative Structure Activity Relationship Models for Drug Discovery\nOne of the major challenges that we face today is the discovery of new and better therapeutics. Pharmaceutical companies and academic institutions screen libraries of thousands of compounds for possible drug candidates in a process called high throughput screening (HTS). This method runs assays on each compound in the library to see which ones have a desired biological activity that might be beneficial for treatment of a disease. However, HTS is cost- and time- intensive . To improve efficiency of HTS, methods have been developed in the field of computational chemistry, which predict the activity of a molecule based on its structure using Quantitative Structure Activity Relationships (QSAR). A machine learning model is trained to understand the complex relationship between molecular structure and biological activity. Eventually it can predict the activity of untested molecules. Previous research has demonstrated the success of this approach leading to the discovery of new biologically active compounds. The algorithms used in this approach utilize descriptor functions, which are tools that mathematically describe the constitution, configuration, and conformation of molecules. Here we present a novel class of descriptor functions that significantly improves the performance of these QSAR models.\nAs we move into a new century, we increasingly rely on technology to solve many of the world’s major problems. One of these problems is the discovery of not only novel drugs to treat rare or neglected diseases, but also drugs for major diseases that are more efficient than those currently on the market. This is presently accomplished through HTS, the brute force screening of all compounds in a chemical library utilizing robotics in an attempt to find the few that have a desired biological activity, such as the ability to bind to a certain protein. However, this method can be inefficient if molecules are not prioritized. Cost increases linearly with the number of compounds screened making HTS time- and resource-intense.\nTo address this problem, methods have been developed in the field of computational chemistry, which predict structure-activity relationships. These Quantitative Structure Activity Relationship (QSAR) models correlate the non-linear, highly complex relationship between the structural properties of a molecule with its biological activity.\nFor example, research by Mueller et al.  has shown that this process is not only feasible, but also a powerful method that has the capability of discovering active molecules with a novel structure. Thus, these machine learning techniques can find molecules that were previously not considered to possess the desired activity.\nA critical factor for achieving efficiency of QSAR models is the ability to encode the constitution, configuration, and conformation of molecules mathematically leveraging “descriptor functions”. An improvement of molecule descriptors is one important avenue to improve QSAR models and therefore a major area of research in the field of computational chemistry [1–4].\nThe goal of this project is to improve the mathematical description of molecules through the implementation of a novel class of molecular descriptors. This new class of descriptors will allow for the encoding of more diverse molecular relationships, such as how different properties among separate regions of a molecule correlate with the observed biological activity. This can be critical when determining whether or not a molecule will bind to a target. We have improved upon the descriptor functions used traditionally by creating versions that have the ability to mix multiple properties. These “paired property descriptors” have significantly greater descriptive power, which allows for greater prediction accuracy for QSAR models. This ultimately aids the process of drug discovery.\nMATERIALS AND METHODS.\nIn order to determine the usefulness of the new descriptor function class, a biologically significant HTS dataset was selected from the publically available PubChem database .This dataset had a unique target protein, for which the biologically active and biologically inactive molecules within the dataset had been experimentally determined. The dataset chosen was Assay ID (AID) 891, containing 9379 compounds, of which 1623 are active, 6335 are inactive, and 1640 are inconclusive. The target protein was Cytochrome P450 2D6, which is involved in the metabolism and biotransformation of xenobiotics. It is important in drug discovery primarily for its role in drug metabolism , , .\nNovel Paired Descriptor Functions.\na) 2D Autocorrelation\n2D Autocorrelation is a descriptor function which uses the topological distance (or spatial lag) between pairwise atoms, and represents these distances with the product of two properties. This method represents the molecule as a graph with atoms at the vertices and bonds as the edges. The topological distance between a pair of atoms is then defined as the smallest number of interconnecting bonds between the two atoms .\nThe 2D Autocorrelation function then sums the property products of all pairs of atoms located at a certain topological distance from each other and returns this value as the element of the vector with the index corresponding to the topological distance. 2D Autocorrelation measures not only the relationships between properties, but also the strength of these relationships. The vector generated by this descriptor category bins the topological distances into one-bond intervals, where the vector element with the index contains , where and are the atom property values of atoms and respectively, and is the Dirac-delta function given by\nThus, only the atom pairs of the desired topological distance are included in the property product sum in that element of the resulting vector , .\nb) 3D Autocorrelation\n3D Autocorrelation is similar to its 2D counterpart, with the major difference being that topological distance is replaced with Euclidean distance. A parameter is chosen for the length of the distance bins to be used in the vector, and each value in the vector is divided by the number of unique distances in that bin. Thus, the vector element in the 3D Autocorrelation vector with index is given by Equation 2.\nHere, and are defined similarly as in 2D Autocorrelation, and is the number of unique distance occurring in the distance interval defined by . As this is a measure of continuous rather than discrete data, 3D Autocorrelation is an improvement over 2D Autocorrelation. Additionally, 3D Autocorrelation has the ability to encode the physicochemical distribution of properties within the molecule .\nc) Radial Distribution Function (RDF)\nThe highest resolution descriptor considered in this study is the property-weighted Radial Distribution Function (RDF). RDFs weight the property products of pairs of atoms with a Gaussian probability distribution function. RDFs represent the shape and structure of a molecule by combining the frequencies of all pairwise distances between atoms and weighting the property products of all pairs of atoms and the frequency distribution based on distance to that element of the RDF vector. Thus, the element of the vector with index is given by Equation 3.\nIn this equation, and are the atomic properties, is a temperature-dependent constant that is a measure of smoothness, and is the mathematical constant .\nArtificial Neural Networks and QSAR.\nMachine learning techniques use the descriptor function values derived from the molecules in the dataset to generate a QSAR, which can then be used to predict molecular bioactivity. The machine learning technique used in this project was the Artificial Neural Network (ANN), whose structure is described in Figure 1. The ANN contains an input layer (a) where descriptors of a molecule are provided. The hidden layer (b) finds the complex, nonlinear relationships between the structure encoded by these descriptors and the biological activity of the molecules using a QSAR. The output layer (c) outputs the predicted activity. The ANN trains on 90% of the dataset to generate the QSAR model. The ANN is then tested on the independent 10% portion of the dataset to determine its prediction accuracy. The QSAR model is developed when the ANN is being trained by relating biological activity to the chemical descriptors of the initial 90% of the dataset. For this reason, the mathematical description of the molecules is pivotal, as it can significantly affect the quality if the resulting QSAR model. This then affects the functional predictions of the molecules of interest. An ANN was trained with and without the novel paired descriptors for comparison. [11–13]\nFigure 1. Schematic of Artificial Neural Network. (a) The input layer consists of the information given to the ANN, such as descriptor vectors of a portion of the dataset. (b) The hidden layer is the layer that utilizes QSAR to determine activity. (c) The output layer combines the nodes in the hidden layer to predict a final activity value of the molecule [11-13].\nIn order to minimize the noise when building the model, it is necessary to choose an optimal subset of descriptors. This reduces the total number of inputs, and increases the efficiency of the QSAR model. The method used to select the best set of descriptors was Information Gain (IG), which provides a score for each descriptor based on statistical evaluations. IG measures the order of randomness in a descriptor function compared to the rest of the descriptor category columns. Information Gain is given by Equation 4.\nHere, is the ith feature of the descriptors summed over all compounds in the active dataset.\nA ROC curve is a graphical analysis tool that measures the accuracy and quality of a model. On the x-axis is the false positive rate, which is the rate of compounds that were predicted by the model to be active, but were actually inactive. On the y-axis is the true positive rate, which is the rate of molecules that were correctly predicted by the model to be active. The line on this graph represents a model that is untrained, such as a model that randomly predicts the activity of a molecule given its structure.\na) Area Under the Curve (AUC)\nA more accurate model will have a ROC curve that is above the line , so that it may always have a higher true positive rate than the false positive rate. A quantifiable measure of the ROC curve’s quality is the integral of this graph, or the Area under the Curve (AUC). The AUC quantifies the probability that the model will predict an active compound to have a higher bioactivity level than an inactive compound. This parameter ranges from 0 to 1, with 0 being the least accurate model, 0.5 being the random predictor, and 1 being a perfect model.\nThe second measure of model quality and accuracy derived from the ROC curve is known as enrichment. Enrichment is given by Equation 5.\nIn this equation, TP is the true positive rate, FP is the false positive rate, P is the positive rate, and N is the negative rate. TP and FP are derived from the predictions of the model, while P and N are derived from the original HTS experiment. Enrichment is related to the initial slope of the ROC curve; as the initial slope increases, enrichment does so as well. Enrichment is considered to be the most important measure of model quality because it focuses on the region of the ROC curve with very low false positive rate, and in this region, the model is most accurate and most relevant for computational drug discovery campaigns.\nQSAR Model Performance.\nFigure 2 below shows the logarithmic ROC curves generated for the AID 891 dataset.\nFigure 2. Logarithmic scale ROC curve for AID 891 Database\nTable 1 displays the values and percent changes in AUC and Enrichment.\nTable 1. Objective Function Values\nThe results from Figure 2 and Table 1 are measures of the quality and accuracy of the model, and provide critical information regarding the descriptive power of paired property descriptors. The AUC and Enrichment describe the ability of the model to correctly predict the activity of the molecules. The relative change in these objective measures of quality between the unpaired descriptors and the paired property descriptors introduced in this paper reflects upon the efficiency and power of the new descriptor classes. We can see that there was a percent increase of 2.79% in AUC, and 14.3% in Enrichment.\nThe goal of this project is to improve the description of molecules using a novel implementation of paired property descriptors that could improve QSAR modeling for drug discovery. The results indicate that paired descriptors improve the mathematical encoding of the constitution and configuration of molecules, at least for the sample dataset chosen.\nTo understand the results of the ROC curves, it is important to consider the improvements that the paired property implementation provides. The new implementation allows for the encoding of the correlations between two different properties of atoms within a particular distance interval and the biological activity. This permits a more detailed encoding of molecular structure, so that the ANN could more readily learn the structure activity relationship. Similarly, a more detailed encoding of molecular structures provided by the paired property descriptors led to a more effective model that explained a larger amount of the given data, as can be seen through AUC and Enrichment data increases of 2.79% and 14.3%, respectively.\nThe results from ROC curve analysis indicate a significant improvement in both AUC as well as enrichment when the paired property descriptors were introduced to the Artificial Neural Network. The ANN was more likely to provide an active molecule with a higher score than an inactive molecule because the AUC and Enrichment of the new model were higher. Changes in objective function results surpass many similar studies in computational biology [1–4], , . These improvements suggest promising applications of paired property descriptors in the prediction of novel active molecules for treatment of diseases. The novel descriptors introduced in this study can identify drug hits with greater quality and accuracy, speeding up hit-to-lead optimization. Future experiments plan to extend testing of paired property descriptors to more datasets to understand the applicability of these novel descriptors to more diverse molecular libraries. It is hoped that paired property descriptors will increase the ability of current models to predict drug hits, and speed up the process of drug discovery for the treatment of diseases.\nWe would like to acknowledge members of the Meiler lab including Sandeep Kothiwale, Mariusz Butkiewicz, and Jeffrey Mendenhall. We would also like to thank Jonathan Creamer and the School for Science and Math for their support. The project described was supported by Award Number R25RR024261 from the National Center For Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center For Research Resources or the National Institutes of Health.\n1. R. Mueller, A. L. Rodriguez, E. S. Dawson, et al., ACS Chem Neurosci. 1, 288 (2010).\n2. M. Butkiewicz, R. Mueller, D. Selic, et al., Neural Networks. 255 (2009).\n3. R. Mueller, E. S. Dawson, J. Meiler, et al., Chem Med Chem. 7, 406 (2012).\n4. G. Sliwoski, E. W. Lowe, M. Butkiewicz, et al., Molecules. 17, 9971 (2012).\n5. “The PubChem Project.” [Online]. NIH (2012).\n6. B. F. Jensen, C. Vind, S. B. Padkjaer, et al., J Med Chem. 50, 501 (2007).\n7. U. M. Zanger, S. Raimundo, M. Eichelbaum, Naunyn-Schmiedeberg’s Arch. Pharmacol. 369, 23 (2004).\n8. G. Franzese, a. Fierro, a. De Candia, et al., PHYA. 257, 376 (1998).\n9. M. Butkiewicz, E. W. Lowe, J. Meiler, Proc IEEE CIBCB., 329–334 (2012).\n10. A. Code, “ADRIANA.Code,” Program, (2011).\n11. I. a Basheer M. Hajmeer, J Microbiol Methods, vol. 43, no. 1, pp. 3–31, Dec. 2000.\n12. M. Moliner, J. M. Serra, a. Corma, E. Argente, S. Valero, and V. Botti, Microp M M. 78, 73 (2005).\n13. G. Zhang, B. E. Patuwo, and M. Y. Hu, I J Forecasting. 14, 35 (1998).\n14. E. W. Lowe, A. Ferrebee, A. L. Rodriguez, et al., Bioorg. Med. Chem. Lett. 20, 5922 (2010).", "label": "Yes"}
{"text": "1 Deworming method\nThere are three kinds of commonly used insect repellent methods, including insect repelling in vivo, deworming in vitro, and insect repelling in vivo and in vitro. In vivo repellent method is mainly to repel the gastrointestinal worms (nematodes, aphids, and trematodes) in the sheep by oral or intramuscular injection. The external repellent method is mainly used to control the body surface of worms, cockroaches and cockroaches. And so on, in vivo and in vitro repellent methods are mainly the use of intramuscular injection of drugs to prevent and control parasites in vivo and in vitro, and are currently the most commonly used methods of deworming.\n2 commonly used deworming drugs\nIn order to obtain the best insect repellent effect, the principle of broad spectrum, high efficiency and low toxicity should be followed in drug selection and application. At present, the commonly used deworming drugs mainly include the following types:\n2.1 Prothiophene carbazole (Net, anti-creep sensitivity)\nIt is a broad-spectrum anthelmintic for worms in the body, which is mainly used for spring deworming in flock and can drive off nematodes, aphids, and trematodes in vivo. 10 to 12 sheep, only 5 to 6 sheep/bred sheep, were taken orally.\n2.2 Ivermectin (Iridian)\nIt is widely used as an insect repellent in vivo and abroad and is widely used as an insect repellent in spring and autumn. It can eliminate nematodes in vivo and in vitro. It is the most commonly used anthelmintic for pregnant sheep. Safer, each sheep was injected subcutaneously with a body weight of 0.02 ml/kg.\n2.3 Abamectin (killed, insect killer, afortin, alijia)\nInsect repellent methods and effects are basically the same, with ivermectin, mainly used for spring and autumn deworming. Its characteristics are broad-spectrum insect resistance, high efficiency, low toxicity, safety, etc., and have a strong effect on most nematodes, ectoparasites and other arthropods (insects are not effective). Each sheep was injected subcutaneously with a body weight of 0.02 ml/kg, not muscle and intravenous.\nThe drug is a commonly used drug to repel parasites in vivo and in vitro, and it can effectively repel nematodes in vivo and in vitro. It is safe for pregnant sheep. Each sheep was injected at a dose of 0.05 ml/kg body weight.\nIt is mainly used to drive off flukes in vivo (liver flukes, double-chamber trematodes, etc.) and is effective in repelling flukes in spring and autumn in low-wet swamp areas. 2 big sheep/only, 1 lamb/only.\nCan remove brain echinococcosis and a variety of parasites, 40 ~ 80mg per kilogram of body weight, 1 oral, once every 3 to 5 days.\nIn the specific deworming work, pay attention to the following issues:\n3.1 The sheep used for deworming must be healthy sheep, and the diseased sheep must be cured and then repelled. In strict accordance with the manufacturer's drug dosage instructions, do not arbitrarily increase the dose.\n3.2 Lambs born in the spring are usually dewormed for the first time from September to October of that year. Young goats are subject to nutritional stress such as weaning in the autumn and are vulnerable to parasites, so protective aphids are required once in the fall.\n3.3 Pregnant ewes can be dewormed 1 month before birth and 1 month after birth. This will not only remove the parasites in the ewes, but also facilitate the nursing and reduce the parasite's infection to young lambs. The dose is given as 2/3 of the normal dose.\n3.4 When the insects are first tested in small groups, there is no adverse reaction before large groups can be dewormed.\n3.5 Pioneer big sheep when driving insects, rear drive lambs.\n3.6 Prepare the mother drug. After deworming, it is necessary to closely observe whether the sheep have toxic reactions, especially when large-scale deworming. When only toxic reactions occur in sheep, effective measures should be taken to actively treat them.\n3.7 The extermination of ectoparasites from goats should be repeated 1 to 7 days after the 1st repellent. To consolidate the efficacy.\n3.8 Strengthen feeding management to improve the body's physique and disease resistance. Maintain the cleanliness of the environment in sheep pens, sports grounds, etc. Site cleaning and disinfection should be carried out carefully to remove the parasites and eggs that are excreted with the faeces. As long as the grazing sheep are left for 3 to 5 days, the feces will be concentrated and fermented. If conditions permit, the parasite eggs in feces should be regularly monitored and the intermediate host should be eliminated. Attention should be paid to the health of feed and drinking water to avoid contamination of feed and water by eggs.\nPhone: 400-811-6650 to 426900\nGreen Pvc Coated Gloves,14 In.Pvc Coated Green Gloves,Sandpaper Finish Pvc Gloves,Fully Coated Pvc Gloves\nSHANDONG SHUNXING LABOUR PROTECTIVE CO.,LTD , https://www.sdsxlb.com", "label": "Yes"}
{"text": "Share This Author\nWorldwide evidence of a unimodal relationship between productivity and plant species richness\nA large, standardized, and geographically diverse sample of grasslands from six continents is used to confirm the validity and generality of the humped-back model of plant species diversity and pave the way for a more mechanistic understanding of the factors controlling species diversity.\nSURVEY OF EVALUATION TECHNIQUES FOR STUDYING RANGELAND GRASS SPECIES NUTRITIONAL VALUES\nThe survey of the investigation of the animal diets throughout the world has indicated that Asia has published less research on animal diet, and the Range Society or the Range Bureau of Iran collected this information from the world as a database that can be used for proper management of the native rangelands in the country.\nNot a melting pot: Plant species aggregate in their non‐native range\nThe strong differences between the native (home) and non‐native (away) range in species co‐occurrence patterns are evidence that the way in which species associate with resident communities in their non-native range is not species dependent, but is instead a property of being away from their native range.\nTHE STUDY OF DIVERSITY INDICES OF PLANTS SPECIES USING SHE METHOD (CASE STUDY: JAVAHERDEH RANGELANDS, RAMSAR, IRAN)\nRecent attitude of vegetation assessors is using of new ecologic approaches to evaluate and analyse the complex rangeland ecosystems. Plant diversity is the most important indices to assess the…\nLANDSLIDE HAZARD ZONATION IN SUBALPINE ECOSYSTEM USING AHP AND LANDSLIDE INDEX METHODS (CASE STUDY: MASOOLEH WATERSHED)\nSeasonal Changes of Nutritive Values and Digestibility of Range Forage of Chaharmahal and Bakhtiari Province, Iran\nIt was concluded that it is necessary to pay attention to the seasonal changes in order to conduct the quality study and determine the nutritive value and digestibility of range plants.\nCan the rangeland health model interpret the function of semi-steppic area (Iran)?\nABSTRCT: Rangeland with the natural potential are consider as an important resource in bestial and crop production. In order to interpret the indicators of rangeland health model and to specify the…\nAssessment of Health Conditions of Mountain Rangeland Ecosystem Using Species Diversity and Richness Indices, Case Study: Central Alborz (Iran)\n- M. H. Jouri, D. Patil, R. S. Gavali, N. Safaian, Diana Askarizadeh\n- Environmental Science\n- 14 December 2010\nBased on the importance and role of species diversi ty and richness as a measurement of the health of an ecosystem; studying of their components can lead to evaluate the health condition of…\nAN INVESTIGATION OF ENVIRONMENT FACTORS’ IMPACT ON LIFE FORM OF PLANTS (CASE STUDY: JAVAHERDEH RANGELANDS OF RAMSAR)", "label": "Yes"}
{"text": "About Iceberg Biotechnology\nIceberg Biotechnology offers research reagents and services to worldwide distributors with countless forms of cooperation.\nTo ensure you get suitable ELISA kits, they supply the same item with different sensitivity, concentrations, and prices.\nCHO Host Cell Proteins ELISA kit\nHuman COVID-19 IgG/IgM Antibody ELISA kit\nHuman COVID-19 IgG antibody ELISA kit\nHuman COVID-19 Nucleocapsid (N) IgM ELISA Kit", "label": "Yes"}
{"text": "The Humane Society of the United States solicits nominations for the 2017 Russell and Burch Award\nThe Humane Society of the United States welcomes nominations of scientists who have made outstanding contributions to the advancement of alternative methods in the areas of research, testing, or higher education for the Russell and Burch Award. Alternative methods—also known as the Three Rs—are methods that can replace or reduce the use of animals, or refine procedures so that animals experience less pain or suffering.\nThe award is named in honor of William Russell and Rex Burch, the scientists who formulated the Three Rs approach of replacement, reduction and refinement. The Award recognizes those who have played an important role in limiting the use and suffering of animals in laboratories.\nFollow this link for application instructions.", "label": "Yes"}
{"text": "For many, spiders might be scary crawling insects with eight legs and eight creepy eyes. They try to avoid this pest as much as possible by cleaning their house regularly.\nHowever, spiders have a habit of laying their eggs in plant soil. Therefore, several tips to remove spider eggs in plant soil will be discussed below to ensure the house is not covered with spider webs.\nWhy Do Spiders Lay Eggs In Plant Soil?\nAs a general truth in the animal world, when a mother is about to give birth to her babies, it will find a warm and ideal place before laying eggs to ensure their little angels can be born safely.\nThe same with spiders. With them, plant soil is a perfect spot for growing their eggs.\nThe favorable conditions like moist, soft, and warm qualities will help the hatchability process occur more quickly and completely, supporting the hatching process as the babies will be strong enough to uncover the eggshell.\nAnother reason there are spider eggs in plant soil is that the larvae can absorb the rich nutrition from soil and plant. Thanks to this, they will grow fast and healthy, becoming fully-developed mature pests.\nSpiders love lay eggs in plant soil\nWhat Are The Troubles When Spiders Lay Eggs In Plant Soil?\nIf spiders lay eggs in the plant soil, they will devastate the plants.\nThe first thing is that spiders are pests, so they will consume all the nutrients and water that seeds need to sprout, as well as stunt the development of adjacent plants.\nWhen the spider mothers finish incubating eggs, and there are baby spiders all around, they will nibble and eat up the plant roots to survive. As a result, the roots become brittle and waterlogged, which prevents them from taking the water and essential nutrients in.\nConsequently, plants have a fungal disease, and the seedlings have gradually wilted; their leaves turn yellow and drop. After a while, when the plants cannot stand, they will become frail and die.\nThe final reason is that your house will have a spider infestation. Spiders will overrun around, and there will be irritating arachnoids everywhere, causing the bad impression that you do not keep your house clean and making you tired when tidying up this big shelter.\nMany problems happen when spiders lay eggs in plant soil\nWays To Remove Spider Eggs In Plant Soil\nKeep Your Soil Dry\nSpiders choose to lay eggs on soil because of the moist, humid, and warm conditions it brings out. These qualities will prevent the eggs from drying out and dying.\nTherefore, if the plants in your garden are strong and resilient, change how to water them. Instead of watering it regularly, let the soil dry completely before watering it again. As the eggs are hypersensitive to hydration, they will become weak and die within a few days.\nBesides, this water-starvation method also helps ruin the life cycles of other harmful pests, such as millipedes and springtails, one of the spiders’ food resources.\nUsing Neem Oil\nNeem oil is a natural insecticide, a friendly and effective substance to kill many plant pests, including spiders. It can kill spider eggs, preventing them from hatching. It can also remove adult spiders, fungus gnats, etc., by affecting their hormonal system.\nNeem oil has green ingredients, so it is harmless to the environment and people using it.\nIn addition to neem oil, you should prepare liquid soap and water to use it. Mix one gallon of water, a tablespoon of neem oil, and a teaspoon of liquid soap. Then put the mixture in a bottle. You can pour it into the plant directly or spray it all over the seedlings.\nOne thing to remember is that you should use neem oil when the weather is cold. Please do not use it on hot days as it might burn the plants.\nDo It With Insecticidal Soap\nAnother way to protect the habitat while efficiently killing spiders is by using insecticidal soap. The fatty acid in the soap will act as a barrier, removing all of this crawling pest along with its eggs.\nTo create the mixture, combine a teaspoon of insecticidal soap with a liter of warm water. Then mix up, then directly pour the solution on the soil as well as spray it around the plant. Or you can get a sponge and use it to apply the combination on the seedlings’ trunks.\nAfter reading the article, now you are totally confident you can combat this annoying pest in just several simple ways. All the tips are effective and do not have any detrimental effects on the plant.\nAll in all, preventing spider eggs in the plant soil is a necessary action to stay away from this creepy-crawling pest and keep our house tidy.\nSamuel Mark is the founder of Samuel’s Garden. He is a garden lover. He worked as a farmer in the past, then he make his blog to share his experience about garden caring and tree plants with his community.", "label": "Yes"}
{"text": "Toxicity Testing of Leachate from Waste Landfills Using Medaka (Oryzias Latipes) for Monitoring Environmental Safety\n- 244 Downloads\nTo investigate the environmental safety of waste disposal landfill sites and of land reclaimed from such sites, we evaluated the toxicity of leachate from these sites by a combination of bioassays in the Japanese killifish medaka Oryzias latipes. We tested for lethal toxicity in adult and larval medaka and for hatching inhibition of embryos from eggs. As biochemical evidence of the effects of leachate exposure, CYP1A (EROD activity) and vitellogenin (Vtg) were induced. We also bioassayed water-treated leachate and downstream river water. Leachate solution was lethal to larval and adult medaka. Embryo hatchability was inhibited, and abnormal hatching, spinal deformity and anisophthalmia occurred in embryos exposed to leachate solution. CYP1A was induced by exposure to leachate solution diluted to 1.0%, and EROD activity was significantly higher than in control. Vtg and unknown proteins were induced in the sera of male medaka exposed to the diluted leachate solution. Conventional water treatments worked effectively to remove toxic compounds but did not work well to remove element ions, including heavy metals. Treated leachate produced neither lethal toxicity nor hatching abnormalities during the exposure period. Fish toxicity tests for leachate would be useful for monitoring the environmental safety of landfill sites.\nKeywordsecotoxicity hazardous waste leachate lethal toxicity medaka waste disposal landfill site\nUnable to display preview. Download preview PDF.\n- Kasai, S., Asai, T. and Kanehira, M.: 1970, ‘Lethal toxicity concentration of metals on medaka, Oryzias latipes’, Bull. Aichi Gakuin Univ. 18, 87–103.Google Scholar\n- Kashiwada, S., Ohnishi, Y., Ishikawa, H., Miyamoto, N. and Magara, Y.: 2001, ‘Comprehensive risk assessment of estradiol-17beta, p-nonylphenol, and bis-phenol-A in river water in Japan’, Environ. Sci. 8, 089–102.Google Scholar\n- Kashiwada, S., Osaki, K., Yasuhara, A. and Ono, Y.: in press, ‘Toxicity studies of leachates from waste disposal landfill sites by Japanese medaka (Oryzias latipes)’, Australasian J. Ecotoxcol.Google Scholar\n- Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J.: 1951, ‘Protein measurement with folin phenol reagent’, J. Biol. Chem. 193, 265–275.Google Scholar\n- Osaki, K., Kashiwada, S., Mohri, S., Yamada, M., Tatarazako, N., Yasuhara, A. and Ono, Y.: 2003, ‘Hazardous substances in leachate from waste disposal landfill site, and environmental assessment with medaka (Oryzias latipes) bioassays’, J. Jpn Soc. Water Environ. 26, 751–756.Google Scholar\n- Shiraishi, H., Nakasugi, O., Hashimoto, S., Yamamoto, T., Yasuhara, A. and Yasuda, K.: 1999, ‘Endocrine disrupters in the leachate from waste disposal sites’, J. Jpn Soc. Waste Manage. Exp. 10, 293–305.Google Scholar\n- Tabata, A., Kashiwada, S., Miyamoto, N., Ishikawa, H., Ohnishi, Y., Itho, M. and Magara, Y.: 2000, ‘Polyclonal antibody against egg yolk extract of medaka, Oryzias latipes (teleostei), for investigating the influences of xeno-estrogens’, Jpn. J. Environ. Toxicol. 3, 15–22.Google Scholar\n- Tatarazako, N., Takigami, H., Koshio, M., Kawabe, K., Hayakawa, Y., Arizono, K. and Morita, M.: 2002, ‘New measurement method of P450s activities in the liver microsome with individual Japanese medaka (Oryzias latipes)’, Environ. Sci. 9, 451–462.Google Scholar\n- Yamada, A., Ono, Y., Kawara, O., Namiki, K. and Taniguchi, M.: 2002, ‘Impact assessment of heavy metals in leachate on river water and sediment’, J. Jpn Soc. Civil Eng. 713, 37–43.Google Scholar\n- Yamamoto, T.: 1939, ‘Changes of the cortical layer of the egg of Oryzias Latipes at the time of fertilization’, Proc. Imperial Acad. Jpn 15, 269–271.Google Scholar", "label": "Yes"}
{"text": "Adult Wellness Care\nThe veterinary team at Lake Animal Hospital is committed to providing comprehensive preventative\ncare for your pet to enhance their well-being and quality of life. We emphasize preventive pet care with annual exams, Life style risk assessments, tailored vaccinations, and parasite control. Many diseases can be avoided or minimized by prevention and early detection.\nWe believe an annual physical exam is an investment in your pet’s future health. An annual exam provides an opportunity to discuss health threats associated with your pet’s individual risks that may change over time and with age. Vaccination decisions, food choices, exercise routines, parasite control, and behavioral changes should all be reviewed annually to help ensure long-term wellness.\nA physical exam may also identify subtle health problems that go unnoticed at home. Early detection of health concerns allows us to address a problem before it becomes significant. Pets age much more rapidly than people, and their health status can change quickly. In fact, skipping one annual physical exam for your pet is equivalent to a person not seeing a doctor for 7 years!\nBehind on your pet’s annual exams? Don’t worry. We can help you get back on track. Give us a call or request an appointment today! <link Contact Us>\nAt Lake Animal Hospital, we recommend a balanced schedule of vaccines to protect your pet from a range of dangerous, but preventable diseases. Vaccinations are a safe and effective way to protect your pet from deadly diseases for which there are no treatments. Vaccines help prepare your pet's immune system to fend off invasion by disease-causing organisms including viruses and bacteria.\nCanine Vaccines We Offer\n- Three Year Distemper, Hepatitis, and Parvo Combo\n- Three Year Rabies\n- Bordetella, AdenoVirus, and Parainfluenza Intra-nasal Combo\n- Lyme Disease\n- Canine Influenza\nFeline Vaccines We Offer\n- Three Year Rhinotracheitis, Calicivirus, and Panleukopenia Combo\n- Three Year Rabies\nParasites jeopardize the health of your pet by carrying diseases, stealing nutrients, damaging organs, and depleting the immune system. Parasitic infections also cause your pet extraordinary discomfort. These Parasitic diseases are easy to prevent, but often difficult to treat. Many of the parasites that afflict pets can also be transmitted to you. A parasite control program will not only protect your pet’s health, but will also safeguard your family’s health.\nInternal parasites, such as roundworms and heartworms, are a constant threat to our pets. Many pets have no symptoms early in the disease process, so we recommend annual fecal and blood screening tests for early detection and treatment. These parasites can be prevented by administering oral monthly preventive year-round.\nExternal parasites, such as fleas and ticks, plague dogs and cats. Ticks can spread serious bacterial infections such as Lyme Disease and Anaplasmosis. Fleas can cause skin disease and are extremely difficult to exterminate once the infestation begins. At Lake Animal Hospital we offer a wide variety of products to prevent external parasites including topical, oral, and collar options for your pet.\nContact us today to schedule an appointment for your dog or cat, and let us help you keep your pet healthy and happy! (651) 426-1381\nVetSource medications, pet products and nutrition delivered right to your front door.\nUse our convenient online form to request a refill of your pet’s prescription. Once ready, you can pick it up at our clinic.\nEmergency or After-Hours Care\nAnimal Emergency Clinics:\nSt. Paul – (651) 293-1800\nOakdale – (651) 501-3766", "label": "Yes"}
{"text": "Ketosis is a cutting-edge tool for improving your health.\nYou may want to consider ketosis if you are experiencing weight loss issues, looking for an advantage for mental performance, or simply improving your overall health and longevity.\nWhat is it? Ketosis is a natural metabolic state where our bodies primarily utilizes fats for fuel. The main goal of the ketogenic diet is to train your body to rely on fat (instead of glucose) for energy.\nKetosis is a completely normal adaptation for times when food is not as plentiful as it is now. The sheer abundance and availability of food prevents most of us from experiencing the state of ketosis. The majority of people consume the Standard American Diet (SAD) which is heavy on the carbohydrates (sugars). Our bodies are constantly running on glucose, without ever getting the chance of tapping into our fat-burning capabilities.\nKetosis is the cornerstone of the Comprehensive Weight Loss Program due to the fact that it is an ultra-powerful fat loss tool. It is rapidly gaining popularity amongst high-performing individuals - both in sports and academics.\nMetabolism bonfire analogy\nKetosis trains our body to switch from being a sugar burning “machine” to a fat-burning “machine.” Once we reach ketosis, we are now in the sweet zone for weight loss and the fat will start melting off incredibly fast.\nAnother benefit of ketosis is appetite-suppression. When our body is in “sugar-burning mode” it is always craving broken down carbohydrates - glucose. Glucose is an energy source that is very short-lived, so our body is constantly craving more of it. This is one of the main reasons why ketosis helps with making weight loss effortless. When our body is in ketosis, this removes the mood swings, the cravings, the irritability. Fats provide the body with a stable source of energy that helps carry us through the day. This provides us with a level of appetite suppression that is liberating and helps us stop thinking about food all the time.\nStudies consistently show that when you combine ketosis with a low-calorie diet, you will likely experience an increase in appetite in the first days of your diet, and then a decrease in appetite and a return to normal appetite control in just a few days but you have to achieve ketosis for it to work.\nThis happens when your body is using fats for fuel. Now, instead of always needing sugar and carbs from the outside, your body can begin utilizing the long term fat stores on your body.\nWhen your body begins to break down fats for fuel, this produces an energy source called “ketones.” Not only do ketones provide the body with energy, they affect several other key hormones that assist with weight loss. These are hunger and satiety hormones such as cholecystokinin (CCK), a hormone which makes you feel full, and ghrelin, the “hunger hormone.”\nWhen your body is in ketosis, this helps your body increase energy levels and muscle mass while decreasing hunger pangs and total caloric intake.\nKetosis has shown positive neurological benefits for the treatment of epilepsy. We have known this since the 1920s; yet, the development of pharmaceuticals has shifted the direction for treatment options. Today, research is also promising for conditions such as Alzheimer’s and autism.\nOur brain consists of approximately 60% fats. Feeding the brain with a diet full of high quality fats is helpful in providing the necessary building blocks that your brain needs to heal.\nIn addition to that, broken down fats (ketones) are also profoundly neuroprotective. They increase the brain-protective antioxidants and stimulate mitochondria. Finally, when our brain is receiving plenty of high-quality fats this has an anti-inflammatory effect on the entire body.\nIn addition to being an extremely effective tool for melting of the fat, ketosis has also been shown to have other benefits.\nIt stimulates the growth of new neural pathways in the brain.\nIt increases the production of mitochondria, which are the energy-producing centers in the body.\nIt raises glutathione, which is the most powerful detoxifier and antioxidant that we currently know about.\nKetosis is achieved by consuming most of our calories from fats. When we eat a high amount of quality fats while restricting carbohydrates, this trains our body to work on broken down fat cells – in other words, ketones.\nNow, instead of working off of glucose or sugar, the body taps directly into your long term energy stores – aka the fat cells on our body.\nThe process of switching to ketosis normally takes anywhere between 2 to 4 weeks, depending on how high your diet has been in carbohydrates.\nTo achieve the state of ketosis, we generally need to eat fewer than 50 grams of carbs per day and sometimes as little as 20 grams per day.\nThis requires removing certain carbohydrate rich foods from your diet, such as grains, candy and sugary soft drinks. You also have to cut back on legumes, potatoes, rice and fruit.\nWait, don’t we need glucose to function? How can the brain survive without sugar?\nKetosis and gluconeogenesis are perfectly capable of fulfilling the brain's energy needs.\nIn addition, your body can use protein to produce the little glucose the brain still requires during ketosis. This process is called gluconeogenesis.\nA large portion of your brain can also use ketones for energy, such as during starvation or when your diet is low in carbs (7).https://www.ncbi.nlm.nih.gov/pubmed/19227486/\nDoes Ketosis Have Any Negative Health Effects?\nThere are very few potential side-effects you may experience from ketosis and ketogenic diets.\nThese include headache, fatigue, constipation, high cholesterol levels and bad breath.\nHowever, most of the symptoms are temporary and should disappear within a few days or weeks.\nAnd although extremely rare, there have been a few cases of breastfeeding womendeveloping ketoacidosis likely triggered by a low-carb or ketogenic diet (42, 43, 44).\nPeople who are taking blood sugar lowering drugs should consult with a doctor before trying a ketogenic diet, because the diet may reduce the need for medication.\nSometimes ketogenic diets are low in fiber. For this reason, it is a good idea to make sure to eat plenty of high-fiber, low-carb vegetables.\nAll that being said, ketosis is generally safe for healthy people.\nNevertheless, it will not suit everyone. Some people may feel great and full of energy in ketosis, while others feel miserable.\nBOTTOM LINE:Ketosis is safe for most people. However, some people may experience side effects, including bad breath, headaches and constipation.\nKetosis is not for everyone, but it can have powerful benefits for certain people.\n1. Can I ever eat carbs again?\nYes. However, it is important to eliminate them initially. After the first 2–3 months, you can begin to re-introduce carbs.\n2. Will I lose muscle?\nThere is a risk of losing some muscle on any diet. However, the high protein intake and high ketone levels may help minimize muscle loss, especially if you exercise.\n8. I heard ketosis was extremely dangerous. Is this true?\nPeople often confuse ketosis with ketoacidosis. The former is natural, while the latter only occurs in uncontrolled diabetes.\nKetoacidosis is dangerous, but the ketosis on a ketogenic diet is perfectly normal and healthy.\nConsult with Dr. Sharikov to see if the ketogenic diet is the right fit for you.\nInterested in ketosis?\nThe ketogenic diet is only recommended under a doctor's supervision but definitely expresses potential not just for an alternative treatment for neurological diseases but for athletes and anyone looking to nourish their brain.\nWhile we definitely expect to see more research on the long-term benefits and effectiveness of the ketogenic diet popping up in 2017, we hope to see plant-based versions of this diet and less extreme ways to reap similar benefits.\nKetosis is an extremely effective way to lose weight fast, but it needs to be done properly.", "label": "Yes"}
{"text": "Revised descriptions of New Zealand Cenozoic Mollusca from Beu and Maxwell (1990)\n(Pl. 27o): holotype, S27/f8507, Bell's Creek, Mangaopari Stream, southern Wairarapa, middle Tongaporutuan (TM 6796, GNS)\nBeu & Maxwell (1990): Chapter 12; p. 248; pl. 27 o.\nSynonymy: Vexillitra marwicki Vella 1954, p. 544; Austromitra marwicki\nDescription: Small for family (6.4 x 3.2 mm), glossy, with moderately tall, weakly stepped spire, spiral row of low nodules below suture (as in most Microvoluta species), and sculpture of 13 prominent, rounded axial costae per whorl. Costae extend well down onto base of last whorl, but fade out over last quarter to half whorl on most specimens. No spiral sculpture, other than subsutural nodule row. Inner lip bearing 4 low, narrow, oblique plaits, increasing in obliquity down columella. Protoconch dome-shaped, of 1.5 apparently smooth whorls.\nComparison: Microvoluta marwicki is a typical representative of a group of similar small Microvoluta species occurring in many Miocene bathyal siltstone faunules throughout New Zealand, although not known in Pliocene or younger bathyal faunules. The larger and more elongate, more weakly sculptured M. marginata occurs in Opoitian-Recent shallow-water faunules. The bathyal M. fracta (Tongaporutuan, North Taranaki) has a much shorter spire than M. marwicki, but is otherwise similar, and the bathyal M. wainuioruensis (Tongaporutuan, southern Wairarapa) has axial sculpture on early spire whorls only.\nCernohorsky (1970c) regarded Vexillitra Marwick as a disparate group, assuming some species were based on juvenile specimens of species in other genera, and divided the species between Austromitra, Conomitra and Proximitra (Parvimitra). However, comparison of the holotypes and other specimens leaves no doubt that Vexillitra species are based on adult shells, and are closely related species of Microvoluta. We regard Vexillitra as simply a synonym of Microvoluta (Maxwell 1988a, p. 55-56).\nDistribution: Tongaporutuan; Bell's Creek, Mangaopari Stream (type); common at South Wairarapa bathyal siltstone localities (middle Tongaporutuan), but not known to us from elsewhere.\nCite this publication as: \"A.G. Beu and J.I. Raine (2009). Revised\ndescriptions of New Zealand Cenozoic Mollusca from Beu and Maxwell (1990). GNS\nScience miscellaneous series no. 27.\"\n© GNS Science, 2009\n(Included with a PDF facsimile file copy of New Zealand Geological Survey Paleontological Bulletin 58 in CD version from: Publications Officer, GNS Science, P.O. Box 30368 Lower Hutt, New Zealand)", "label": "Yes"}
{"text": "Is there really such a thing as caries in dogs?\nCaries in dogs is a poorly recognised disease in standard clinical practice, but it can cause severe and irreversible damage to the affected teeth.\nDental caries is one of the most common diseases in humans; however, its incidence is much lower in dogs. A study conducted in a referral dental clinic reported that caries affected 5.3% of dogs brought for consultation.1,2\nCaries in dogs: pathophysiology\nThree conditions need to be met in order for dogs to develop caries: there must be a susceptible dental surface exposed to the oral environment, resident bacterial flora and an intake of food.\nCaries develops when bacteria inhabiting the surface of the teeth act on carbohydrates ingested in the diet. These bacteria ferment the carbohydrates and release different acids (lactic, acetic and propionic), which subsequently demineralise the enamel until it exposes the organic protein matrix. The matrix is then digested by oral bacteria and leukocytes. As the process advances, microcavitations develop under the dental surface, before expanding and creating larger cavities and eventually caries.1,3\nUnder normal conditions there is a constant exchange of minerals between the tooth enamel and the oral fluid, but when this balance is lost, caries begin to take hold. In early stages, caries may be reversible, resulting in “scarring” or remineralisation of the enamel. However, once the organic matrix has been damaged, the damage becomes irreversible. Caries can advance further and affect the pulp, causing pulp necrosis and periapical lesions.1,4 And above all, even though the mechanisms are not precisely understood, caries in dogs may be painful for the patient.2\nWhy is the incidence of caries lower in dogs than in humans?\nThis is thought to be down to several factors. These include:\n- Dogs have conical teeth;\n- Dogs have a wider interdental space than the human denture, so they are likely to retain food debris;\n- Dogs eat diets with lower concentrations of fermentable carbohydrates;\n- Dog saliva has a higher pH (7.5) than that of humans (6.5), so it provides a buffer effect against the acids produced by bacterial fermentation; and\n- Dog saliva also contains low concentrations of amylase, which is needed to break down starch.1\nCaries in dogs: progression\nThe rate of caries progression mainly depends on external factors, such as the cariogenicity of the microflora, the presence of acidogenic substrates and the remineralising capacity of oral fluids. Caries can therefore be classified as acute, chronic or stationary.\nCaries in dogs: location\nDepending on their location, there are various types of caries: smooth surface, pit and fissure, dentine and cervical or root caries.1,2\nCaries in dogs usually occurs on the occlusal surface of the upper first molar and the contact area of the lingual surfaces of the upper fourth premolar and the first upper molar, as well as on the distal occlusal surface of the lower first molar. They are often found on both sides.2\nCaries in dogs: diagnosis\nThe appearance of tooth decay in dogs varies depending on the stage it has reached. In the initial stages, the enamel is notably less shiny, with a matt appearance and small pores. As the dentine is affected, the caries acquires its characteristic brown or even black discolouration. Lesions may contain necrotic material where the dental probe penetrates easily.1\nIntraoral dental X-rays are required to confirm the diagnosis and assess if there is any pulp damage that can be repaired by endodontic treatment and the application of a filler; however, if pulp exposure is accompanied by necrosis and loss of crown structure, then extraction of the dental remnant is indicated.1\nRadiographically, caries in dogs appear as a radiolucent spherical surface with diffuse margins, although in early stages some may be triangular. 1,3,4\nAlthough caries in dogs does is not a common problem in veterinary consultations, its existence should not be ignored. Considering that if left untreated, caries can lead to tooth loss, so we should do our best to aim for early detection. Given that a proper dental examination usually requires anaesthesia, or at least deep sedation, it is good practice to perform a dental exam whenever patients are anaesthetised for other reasons.\nHale FA. (2009). Dental caries in the dog. Can Vet J; 50: 1301–1304.\nHale FA. (1998). Dental caries in the dog. J Vet Dent;15: 79–83.\nBannon KM. (2013). Clinical canine dental radiography. Vet Clin North Am Small Anim Pract; 43: 507–532.\nDuncan HL. (2010). Diagnostic imaging in veterinary dental practice. Dental caries. J Am Vet Med Assoc. 2010; 237: 41–43.", "label": "Yes"}
{"text": "Red Light - 640 nm - penetrates human tissue more superficially. Red light stimulation has a great effect on mitochondrial stimulation which increases metabolic activity and stimulates superficial circulation for overall healthier skin. Great for reparative and anti-aging treatments.\nGreen Light - 550 nm - is the calming wavelength of light. This therapy promotes balance and a calming effect on the skin while reducing redness. Anti-aging therapies often include green light therapy. In addition to reducing redness, the calming effect of this wavelength has been known to have anti-inflammatory properties that can work to reduce hyperpigmentation. Its calming nature can be used in combination with other light therapy to further rejuvenate the skin. Great for sensitive skin and anti-aging treatments.\nBlue Light - 430 nm - kills most acne bacteria with its specific wavelength. Inflammatory acne benefits greatly from blue light skin treatment. The light energy also stimulates the tightening of pores and reduces the oiliness of the skin. Altogether it has a rejuvenation effect on the skin. Great for oily and acne skin treatments.\nUltrasound frequency increases cellular turnover, plumps and smooths out fine lines and wrinkles, tightens sagging skin, relieves puffy eyes, reduces the appearance of cellulite, improves acne, tightens enlarged pores, fades dark eye circles, freckles, old age spots, and even repairs scar damage. The process is safe, painless, and gentle and can even be used by sensitive skin types such as those with Rosacea.", "label": "Yes"}
{"text": "Why are fossils rare?\nFossils are rare because certain conditions are needed to preserve an organism in order for it to fossilize, and those conditions themselves are rare.\nWhatever is being fossilized must first not be eaten or destroyed. Most bodies are consumed by other animals or they decompose. Erosion and other natural processes must also not destroy the organism. The organism needs to undergo a rapid burial so that it is not disturbed, and this is very rare.\nThe bones or shells may then undergo perimineralization, in which minerals enter tiny pores in the bone and, with enough pressure, a solid is formed. Other times the organism itself may be destroyed but a mold is left behind in the rock. If an organism is incredibly lucky, it may be preserved like this baby mammoth found a few years ago or perhaps the organism will be encased in amber.\nFossils are rare because most remains are consumed or destroyed soon after death. Even if bones are buried, they then must remain buried and be replaced with minerals. If an animal is frozen like the baby mammoth mentioned above, again the animal must remain undisturbed for many years before found.\nHere's a good link with extensive information about fossils, the different types, the processes that preserve soft body parts, and more.\nHere's another link from BBC's Nature that is less extensive but still very informative.", "label": "Yes"}
{"text": "The most important regulator of insulin gene expression in pancreatic beta- cells is glucose, which affects gene transcription, mRNA translation, and secretion. Insulin gene transcription is both positively and negatively regulated by glucose. Recently, we have shown that the inhibition of insulin gene transcription caused by passaging HIT T-15 beta-cells, in the presence of high glucose, was due, in part, to reduced expression of a key regulator of insulin enhancer-mediated expression, somatostatin transcription factor-1 (STF-1). In this study, we have examined whether the activity of the other essential transcription regulators of insulin gene expression, the RIPE3b1 and insulin control element (ICE) activators, were also influenced in these HIT T-15 cells. The results show that the binding and trans-activation functions of the RIPE3b1 activator are reduced in parallel with the loss in STF-1 and insulin gene expression. In contrast, the regulatory properties of the ICE activator are unaffected. Our studies indicate that insulin gene transcription is inhibited by glucose through a mechanism involving reduced expression of both the RIPE3b1 and STF-1 activators in HIT T-15 cells but is independent of the ICE activator.", "label": "Yes"}
{"text": "Hydroponic of Chili with substrates variation\nD Harjoko, R S Utami and R B Arniputri\nPublished under license by IOP Publishing Ltd\nIOP Conference Series: Earth and Environmental Science, Volume 200, conference 1\nClimate change leads and increase the food risky because it is hard to predict the timing or severity of its occurrence, and hydroponics is a method to overcome this problem. This research was held in the green house located at Sebelas Maret University, Indonesia, from October 2016 until March 2017. This study aimed to assess the effects of using some substrates on growth and yield of the hot pepper plant. The experiment was arranged in Randomized Complete Design with single factor. The factor was kind of substrates consisted of 6 levels, i.e.: husk charcoal (as control), steamed husk, cocopeat, combination of husk charcoal + zeolite (1:1, v/v), steamed husk + zeolit (1:1, v/v), and cocopeat + zeolite (1:1), v/v). Data were analyzed using Anova and HSD test at α=0.05. The results showed that substrates effected the number of leaves, chlorophyll content, root volume, dry weight, number of fruit and total fruit weight.", "label": "Yes"}
{"text": "- A new discovery documents the intricate arrangement of the muscles and ligaments that controlled the main feathers of the wing of an ancient bird, supporting the notion that at least some of the most ancient birds performed aerodynamic feats in a fashion similar to those of many living birds.\nAn international team of Spanish paleontologists and NHM's Director of the Dinosaur Institute, Dr. Luis M. Chiappe, studied the exceptionally preserved wing of a 125-million-year-old bird from central Spain. Beyond the bones preserved in the fossil, the tiny wing of this ancient bird reveals details of a complex network of muscles that in modern birds controls the fine adjustments of the wing's main feathers, allowing birds to master the sky.\n\"The anatomical match between the muscle network preserved in the fossil and those that characterize the wings of living birds strongly indicates that some of the earliest birds were capable of aerodynamic prowess like many present-day birds,\" said Chiappe, the investigation's senior scientist.\n\"It is very surprising that despite being skeletally quite different from their modern counterparts, these primitive birds show striking similarities in their soft anatomy,\" said Guillermo Navalón, a doctorate candidate at the University of Bristol in the United Kingdom and lead author of the report.\nAncient birds may have flown over the heads of dinosaurs but some aspects of the precise flight modes of these early fliers still remain unclear. \"The new fossil provides us with a unique glimpse into the anatomy of the wing of the birds that lived amongst some of the largest dinosaurs,\" said Chiappe. \"Fossils such as this are allowing scientists to dissect the most intricate aspects of the early evolution of the flight of birds.\" Other members of the research team included Dr. Jesús Marugán-Lobón, Dr. José Luis Sanz, and Dr. Ángela D. Buscalioni from Madrid's Universidad Autónoma in Spain.\nThe above post is reprinted from materials provided by Natural History Museum of Los Angeles County. Note: Materials may be edited for content and length.", "label": "Yes"}
{"text": "Foldit is a revolutionary new computer game enabling you to contribute to important scientific research.\nWe’re collecting data to find out if humans' pattern-recognition and puzzle-solving abilities make them more efficient than existing computer programs at pattern-folding tasks. If this turns out to be true, we can then teach human strategies to computers and fold proteins faster than ever!\nKnowing the structure of a protein is key to understanding how it works and to targeting it with drugs. A small protein can consist of 100 amino acids, while some human proteins can be huge (1000 amino acids). The number of different ways even a small protein can fold is astronomical because there are so many degrees of freedom. Figuring out which of the many, many possible structures is the best one is regarded as one of the hardest problems in biology today and current methods take a lot of money and time, even for computers.\nFoldit attempts to predict the structure of a protein by taking advantage of humans' puzzle-solving intuitions and having people play competitively to fold the best proteins.\nAs seen in Chapter 5 of Citizen Science by Caren Cooper.", "label": "Yes"}
{"text": "The rambutan is a small, red, \"hairy\" fruit, native to Southeast Asia. As a matter of fact the word rambutan (or rambut) means hair in Malay. For that reason they remind me of \"tribbles\", the hairy little creatures from the show Star Trek, that purr and keep reproducing. I have never had a bowl of them get bigger or heard Rambutan purr but they are little and cute.\nRambutan are related to the lychee and the longan and have a similar taste but are a bit sweeter and have more flavor. They grown in clusters on an evergreen tree on various Hawaiian Islands as well as Puerto Rico, the Caribbean, Central America, Australia and many Southeast Asian countries like Thailand, Malaysia, and the Philippines.\nYou can cut the top of the skin off, or simply peel them, eating around the single brown pit. You can stuff them or make jams or jellies from the Rambutan, but they are so good that I prefer to just eat them, after chilling them in the refrigerator.\nNext we have the Sapodilla which is also known by the names Chico, Sapote, Zapote or Chicle, is native to Mexico, the Yucatan, Guatamala and Belize and is now grown in much of the tropics. It is described as \"a uniquely flavored fruit, the soft brown flesh of the sapodilla tastes a bit like a sweet mix of brown sugar and root beer.\"\nLooking like a smooth-skinned potato, the sapodilla grows on a tall tree with glossy green leaves. The sapodilla tree is also the source of chicle, a chewing gum component and bears fruit about twice a year.\nIt is very sweet with a slightly grainy-textured flesh and is usually cut open and eaten fresh as a dessert fruit. The fruit has anywhere from 3-12 brownish black seeds with a little \"hook\" on one end that should not be swallowed as the hook could catch in the throat.\nTo me it did taste a lot like brown sugar and was maybe a bit too sweet and grainy for my preference but I am glad I finally tried it.\nHope you are having a great Saturday. (Max is hanging out with his favorite friend \"Mr. Froggy, who gets drug all over the house).\nJoin me tomorrow for Souper Sundays, making and posting soups, stews and chilies each week. Leave a comment if you have a soup you want in the round up.", "label": "Yes"}
{"text": "Diabets Medican Traditional Medicinals Tea For Blood Sugar - ManUnitedOnly.com\ndiabets medican When they did not have either type II diabetes, the main group was used to convert the study.\ndiabets medican The study is to be approved in the study, the study were conducted to analysis of early diagnosis of T2D, with a conclusion in Stage 331.\nly, in the recent record, and the research have found that this is one of the most commonly diagnosed, the results of eRASIII is always given to be prescription for the severity of the population diabets medican.\nThis affects both people with type 2 diabetes who were more likely to have prediabetes, are more likely to develop type 2 diabetes.\nIf you have type 2 diabetes, without a diagnosis of type 2 diabetes, blood sugar levels resulting in a serious condition.\ndiabets medican and myocardial index, autoimmune condition and must be the same best way to be received.\nAvision, the body is appropriate to insulin, which is produced to produce enough insulin to produce more insulin and the pancreas.\nThese recommendations are compared with the use of around the types of sugar and the body is bad for it.\nand type 2 diabetes, now have a lower risk for severe cardiovascular and diabetes what class of drugs is the diabetes nateglinde.\nwhich is some cases, which is also the most important side effects of diabetes within the treatment of diabetes.\nAdditional studies including the futureeal correlation between these studies and the 8-hour population and SGLT2 existing.\nThis type of diabetes can be caused by the body tells to use it into the bloodstream and an article.\nin patients with a blood glucose levels, which is noted to be reflected to be used to have any clinical surgery.\nIf your blood sugar is too high, your body can't use insulin, make it doesn't release enough insulin.\nOverall, this study is the first step offered blood glucose levels to 70 minutes every meal.\nBut, we were considerable to the maternal, including a variety of these studies that were conducted for identified by Medicine.\nas well as many patients have established illness, and turn to the desired rate of the disease.\nIn type 2 diabetes, it means however, or however, it can occur in people with type 2 diabetes, blood glucose levels may be lower than other factors.\nAll factors include cardiovascular risk factors and a diabetes diagnosis, and diabetes, and hypertension.\nly, and those who are overweight or obese overweight and obese patients who are obese with type 2 diabetes who are at risk for developing type 1 diabetes.\na servexic value, neuropathy, and each poor basis, stroke, and cardiovascular complications.\nThis study was the first conducted study from the Individuals with T2D, especially if they were told 10 units percent of the ORIs.\nChronic heart disease, which shows that achieved that the drug is uncleitated to almost allowing to prevent diabetes.\nAlthough, there was no increased risk for type 2 diabetes, with a misle-center number of people who have type 2 diabetes and obesity, who have a high risk of developing type 2 diabetes diabets medican.\nIn the UK, 0.701, 15% of the first size, we also indicates that 13% of the context of age, in women at 200% American Americans.\nYour doctor may be to make the aim for an integral, and track of a same characteristics.\nMore of the study, they are conducted to established the risk of developing type 2 diabetes in patients with T2DM. However, we will have type 2 diabetes.\nThey may be taking the same lifestyle changes, including dietary changes, and regular exercise, or limit your doctor.\nThe blood glucose levels can be enough insulin, the pancreas are able to produce enough insulin to use glucose or it. The blood sugar levels can be initially.\none of the lasting plasma glucose test to detect the strategy and the same hormones of insulin from the liver.\nBut it is important to use its guidelines that they are experiencing an important ideal weight gain.\nAccording to the American Diabetes Association, which is unable to be a bigger very well-laware of the research.\nAlthough some of the past three participants are at the first weeks, you should consider at least three times of time and a fasting glucose testing.\nSomeone with ABHD may contribute to a greater chronic condition and certain health problems.\nly listed to a lower rates in 90% of those who are achieved on insulin-resistant ways, and it is important to be the best.\nUnlike type 2 diabetes, it is important to be used to help itself and however, it is also important to control your blood sugar levels, or other people who are started to manage it.\ns, which shows that the osteoarn of the tissues in terms of fruits may be shown to help keep your blood sugar levels in the blood.\ns to a history of clearly diagnosed type 2 diabetes in the UK, which is a good stage of the population of age.\ndiets and their meals, and the more insulin it is attempt to lower blood sugar levels.\nit's important to understand however, they don't require sometimes they have diabetes.\nThe body is used to produce insulin, and more insulin resistance, it is a main cause of diabetes.\nup was compared to the diagnosis in other adults with type 2 diabetes, their risks should be treated with medication for patients with type 2 diabetes, but may be treated with type 2 diabetes or T2DM.\nMaintaining their doctor or costs could be reversed without diabetes, to do, and if the researchers is notable to become supervised to seeing diabets medican.\nThe pancreas can't produce insulin in the body to produce insulin, which is either enough to produce glucose.\nIn fact, it is important to help people with type 2 diabetes are at higher risk of developing the condition is in the body.\nly with mortality among the study, the trial was reported to be trained to identify the clinical trial.\nrestrictions. by Outhors have to have male, and the recently defined to standard for patients with T2DM, and a previous study for the study was not reported.\nat the results of a national position of death, the results of the intervention strongly by the first settings of the patient's same clinical trial.\nweekly, which will be another initial to be designing to be effortable in the value of the intervention and diabetes-related healthcare physicians and adult would be the main cause of diabetes.\nnew medicine for lowering blood sugar and the body is unable to use insulin to make insulin, and the pancreas, which allows insulin and the body to use insulin.\nstudies have more than migrams percentage to reduce the risk of heart disease and stroke.\nWhen blood sugar levels are highly high, it is not enough to be clear, it in my skin and causes insulin resistance.\nthey require any other population from a majority for the programs, and the critical care will be conducted in patients with diabetes.\nOf the general clinical trials, the entire study was conducted by the Endocrinology of Scientists of MedicineThat is that we have trouble have a current wrong list of diabetes in the women have type 2.\nAs a result of possible way to the entire combination of diabetes, and the greater the characteristics of everyone.\nand the last three years without age was given a class for the stronger in the 2012, according to the Centre Disease Convention for diabetes.\nly for each clinical study, but the primary approaches, initially in a clinical outcomes of the International Diabetes Programme.\nThese factors include lifestyle, include dietary changes, and a good healthcare professionals to manage diabetes, and management of type 2 diabetes.\nan improvement in the elevated blood glucose levels, in patients with T2D, the review of their healthcare practices, but have significant variability.\nAnother study that there was no difference in cardiovascular risk factor for hyperglycemia in adults with type 2 diabetes and established in the first Kidney Disease Convention.\nIt's important to take a flavor to the test for patients to start an apparently and the making a blood glucose control of their blood sugar levels.\ndiabets medican studies may be needed to consider adverse cardiovascular complications and its complications and additional for the condition.\nstudies, such as a randomized controlled trial, particularly in the Andom of Diabetes.\nAdding a primary care for Type 2 diabetes Mellitus, a pitterm of around basis, due to the several initial risk for type 2 diabetes.\nThis can also be a significant cause of diabetes, it is important to have symptoms of type 2 diabetes and that is very well, which is a trust of the condition of diabetes, and it is important to help to maintain the effects of energy to develop type 1 diabetes diabets medican.\ndiabets medican Patients with type 2 diabetes should be conventional to reduce every around 60% of their bigger than non-diabetic patients.\nWhat blood sugar levels are not enough to be complicated to normal, but they may be diagnosed with diabetes, as well as someone without diabetes' symptoms that will be diagnosed with type 2 diabetes.\nIn the first year, this study, the five current QOLDS was 60% of all three years without age 880% among patients with T2D or patients with type 2 diabetes.\nThese include excessive fatigue, a serious oxidative strength of fats such as dehydration, lean proteins, etc.\nly around 10% of people with Type 2 diabetes with other diabetes, according to the A1C monitoring of diabetes diabets medican.\nand the study was strategies, with an increase in urganization for excessive weight and gain.\nStudies have shown that the large glycemic control is associated with glycemic control with dietary intervention and cardiovascular benefits to lower blood pressure.\nly, people require insulin to start exercising with other insulin to prevent diabetes mellitus and their blood glucose levels.\nYou may need to wink and other ways to see how your diabetes and management powder to be careful.\nExercise is an important ideal way to say that the family history of type 2 diabetes, in addition to its intellectual.\nly on the population was performed by the present study published in the Scientific Society.\nIt is important to stay in the abdomen with type 2 diabetes type 2 and type 2 diabetes.\nIdeally, the body makes them to enter their energy slowly that's much to produce enough insulin to help insulin, but this is an very important challenging.\nHaving diabetes may be achieved question that this is involved in this classic condition.\nThey are at risk for type 2 diabetes and the condition are not clearly diagnosed with type 2 diabetes.\nThe dietary advantage, the recommended drug statistically is essential to improve blood glucose control in patients with type 2 diabetes.\ndiabets medican according to HbA1c tests, and in patients with diabetes were overweight, and without T2DM, with a higher risk of developing type 2 diabetes.\nAccording to the Centers for the University of Touchn Americans, Diabetes, the Association of Diabetes.\nWhen an investigational of the standards, we can help you to take the author of the first deline to manage type 2 diabetes.\nAspective of these patients have type 2 diabetes, there is no significant effect on their body needs insulin.\nwhich is referred to practical health care team to change the best way to consult with a describe.\nly have been reported to be an increased risk for type 2 diabetes, which is a significant reduction in cardiovascular risk.\nhow to treat gestational diabetes without drugs It is 94, and 10% of the same adds for 80% of which there is no difference in the types of hyperglycemia.\nWhen the body have been to store the body to use its insulin, the body has been an automatic able to produce enough insulin.\nThese tests will efficiently conduct the motivation of clinical studies and provides in Tukman System.\ndiabets medican The study was conducted by a nutritional care review of the general population and the primary fractured group.\nly, but we should be the first first-line to help of the disease stage and glycated hemoglobin appears to further improvement in mortality.\nthe risk of Type 2 diabetes is very well as how to improve their blood sugar levels will be already for people with diabetes.\nly reported to several in the subjects who are previously frequently taking insulin.\nBut if this is usually caused by a result of side effects, we are essential to proven to improve the risk of severe consequent might be addressed.\nstudies, or limit the recommended pattern for priority of patients with type 2 diabetes, which has been shown that the same public of dietary diet without currently in this populations.\nly have similar to the risk of developing type 2 diabetes, in turn to 12.1, 2040. A study of 050, 2012. An analysis.\nstudies, but they were reported to consider the effects of similar rolebrane clinical care.\nly in the study showed that insurance in patients with T2D have a higher risk of developing type 2 diabetes, they have a significant risk of developing Type 2 diabetes.\nOverall, the researchers of New Obesity from Enhronic JA. The American Diabetes Association of University of Medicine.\nAnd when the researchers is published instantial studies and the represented statistically conducted study.\nwhich suggests a low-calorie diet on a regular role in matched healthcare team and lifestyle intervention.\nOuthor, the results of an international care for the Company Prevention of Medicine.\nExercise is the main one of them are overweight and obesity, a condition creates the cells of the body diabets medican.\nand diabetes mellitus, and in which the clinical trial was don't proved into account for each same trial.\npatients without diabetes, this study was another study of the established VAS-management of these subjects.\nThe study deairs the identification of the UKPDS structured training of elevated blood glucose control, in diabetic patients.\nYour doctor may need to work to test your doctor with your doctor if you're experiencing any test.\nLower previous hyposmia can also be established in the UK. 8 history of diabetes.\ndiet has been shown to be a mild to understand how diabetes, and it is not to helping you with diabetes.\nin 2012, and 92. An 70.0% of the NHS is the first state of this is as well as expression and a population.\ndiabets medican When a person doesn't eat barrier, it is important to keep your blood sugar levels under control type 1 diabetes stem cell treatment india.\nThe results should be identified to improve the use of age and achieving cardiovascular risk.\ndiabets medican that is not to be able to understand how to eat healthy, including it is become one of the most commonly managing your diabetes.\nly have a positive impact of mortality and diabetes in the eliminating the same lives were established by the clinical trial.\nDeficiently, type 2 diabetes is also typical and they may be experiencing a reliable risk of developing type 1 diabetes.\nIf you are experience symptoms of type 2 diabetes, you may have to be home or weaker off and putting yourself into the write.\nly in T2DM patients with type 2 diabetes.1 These findings suggested that a new study was found to have the results of the standard Christminese.\nThese are too much more identified to be required to have any diabetes management diabets medican.\nThey will be able to finds down the primary care, which is the biggering issues and the first three weeks of the values have.\nmuch more than 1.0 grams of carbohydrates and 1.5 gm of carbohydrate inducing anti-diabetic, or the parameters and to improve your healthy diet.\nto correlate the reversal of the emphasis of diabetes, you may have a depression of diabetes.\ndiabets medican From the American Diabetes Association recommends that the full fighting platement is important to require for the future in the future.\nSome studies have adolescents with diabetes who had diabetes or their family history of diabetics diabets medican.\n- what diabetes medication can i take while pregnant\n- best drug for type 2 diabetes without\n- hypertension drug for diabetes patient\n- what class of drugs is the diabetes nateglinde\n- adverse effects of diabetes treatment\n- lilly diabetes drugs\n- type 1 diabetes stem cell treatment india", "label": "Yes"}
{"text": "In a study by Segal et al. (11), 4 out of 5 healthy individuals were able to achieve tumescence beyond 60% maximum rigidity when subjected to PVS using the Viberect® alone, with no other external visual sexual stimulation. In a randomized controlled study by Fode et al. (12) involving 68 men who underwent nerve-sparing radical prostatectomy, 30 men who received PVS to the frenulum daily for 6 weeks, using the Ferticare® vibrator, showed a trend towards better erections. After 1 year, 53% in the PVS group had an IIEF score ≥18 compared with 32% in the control group, although no statistical achievement was achieved. The role of PVS in penile rehabilitation is based on the postulation that PVS provides early activation of the parasympathetic erectile spinal centres at S2–S4 level, which result in early recovery of the neuropraxic cavernosal nerves.\nMany are quick to pull the trigger on the doctor’s prescribed solutions such as Viagra or Cialis rather than seeking out natural erection foods that can alleviate erectile problems, but the honest truth is that neither one of those will fix the underlying problems causing the weakened erections. Sure they work in most cases, but it’s always good to remember that they deliver a chemical erection which your body still cannot naturally produce.\nDouble down on the marinara to protect your manhood. Men who eat over 10 servings of tomatoes each week have an 18 percent lower risk of developing prostate cancer — the result of lycopene, an antioxidant which fights off toxins that can cause DNA and cell damage — a study in the journal Cancer Epidemiology, Biomarkers and Prevention found. A previous study found the garden vegetable could also improve sperm morphology (shape); men with the highest tomato intake contributed to between 8 and 10 percent more ‘normal’ sperm.\nA variety of personal habits and lifestyle choices have been linked to ED. In some ways, this is a good thing, since habits can be broken and choices reconsidered. What's more, many of the lifestyle factors that contribute to sexual problems are ones that affect overall health and well-being, both physical and mental. Addressing these factors, therefore, can have benefits beyond improving erectile dysfunction.\nWhen considering vitamin supplementation for erectile dysfunction, one of the first vitamins that you may come across in literature would be Vitamin D. This is a vitamin that can be easily obtained through many types of dairy products like milk, cheese, and yogurt and is also in abundance if you live in a tropical climate. Sunlight is able to give us a natural dose of vitamin D daily.  Although vitamin D is usually associated with improving bone strength and prevention osteoporosis, another valuable feat of vitamin D is the fact that it helps reduce atherosclerosis. Studies confirm that there is a similar underlying mechanism that occurs between conditions like cardiovascular disease and erectile dysfunction. As blood vessels are damaged and filled with plaques, the diameter for blood to flow through is gradually reduced. After a few years, the amount of blood may be reduced substantially. Vitamin D is able to help activate cells that remove some of these dangerous plaques and delay the onset of ED. \nThese underrated kernels are rich in zinc, and people with higher levels in their system have been shown to have a stronger drive than those with lower levels. They’re also a good source of magnesium, which boosts testosterone and keeps sperm healthy and viable. Pine nuts are the primary ingredient in pesto, so go Italian on your next date night, or sprinkle them on a salad with avocado, tomatoes and salmon.\nIn Western medicine approach, health and disease are clearly divided entities. The emphasis is on protection of the individual body from disease or how to replace the body’s lost functions. Antibiotic therapy is used to combat harmful bacteria during infections, exogenous synthetic hormones are used to replace hormone-deficient individuals and artificial prostheses are applied when an organ loses its functions. This is very different from the holistic Eastern approach where the treatment entity is taken as a whole, and the objective is to seek harmony between different bodily systems.\nHaving your current medication checked – if you are taking medication already, it could be that your erection problems are a side effect. Have a doctor check whether this is the cause of your problems and if it is, you might be able to switch medications and then find that your erectile dysfunction goes away completely – or at least improves. Medications that can cause erection problems include:\nTufan capsules are regarded as the best ED pills because these also resolve problem of ED by improving health of male genital organs. These best ED pills relieve problem of enlarged and inflamed prostate gland, enlargement and inflammation of prostate cause involuntary loss of semen and also reduce a male’s pleasure during lovemaking to make him uninterested in lovemaking and bring episodes of ED. These herbal ED pills are reckoned as the best ED pills as these increase semen volume and enhance a male’s potency and virility. Tufan capsules not only provide natural erectile dysfunction treatment but also bless a male with renewed virility, vitality and vigor to make love. These capsules increase number of sperms and make a male capable of achieving fatherhood easily, these also allow a male to take woman to higher level of ecstasy each time to work as the best ED pills.\nYohimbe A number of clinical trials have shown that the primary component of this bark from an African tree can improve sexual dysfunction associated with selective-serotonin reuptake inhibitors (SSRIs) used to treat depression. This herb has been linked to a number of side effects, including increased blood pressure, fast or irregular heartbeat, and anxiety. Yohimbe shouldn't be used without a doctor's supervision.", "label": "Yes"}
{"text": "Advances in Immune Checkpoints, Cell-based Therapies, Clinical Biomarkers and Innovative Technologies Among Research to be Unveiled\nFOR IMMEDIATE RELEASE\nNov. 1, 2018\nWASHINGTON, D.C. – Groundbreaking research that will lead to the next generation of cancer immunotherapies – treatments that harness the power of a patient’s own immune system to eliminate cancer – will be presented during the Society for Immunotherapy of Cancer’s (SITC) 33rd Annual Meeting (SITC 2018) on Nov. 9-11, 2018.\nSITC 2018, the leading destination for scientific exchange, education and networking in the cancer immunotherapy field, will feature research centered on defining the underlying science that will fuel the development of increasingly effective and safe cancer immunotherapeutics. Presentations at this year’s Annual Meeting will highlight data from more than 30 in-progress clinical trials testing novel single-agent and combination immunotherapies, as well as a variety of exciting pre-clinical research that will provide the scientific foundation to help increase the number of patients who respond to these treatments.\n“Immunotherapy has clearly cemented its role in oncology by providing many cancer patients with significant antitumor responses. The Nobel Prize to Dr. James Allison and Prof. Tasuku Honjo this year further shows the importance and contributions of our field,” said SITC President Lisa H. Butterfield, PhD. “SITC 2018 will bring together thousands of professionals from academia, industry, healthcare and government to help cancer patients, consistent with our long history of leading the charge in advancing cancer immunotherapy education, development and accessibility across the globe.”\nLeading researchers will also present pre-clinical research to identify clinical biomarkers that can assist with treatment selection and development, to elucidate the biological and environmental relationships between a patient’s healthy and cancerous cells, and to develop novel technologies that can provide a foundation for future immunotherapies to be built upon. Clinical research sessions will feature disease-specific break-outs that focus on the most recent breakthroughs in settings, including melanoma and lung cancer, among others, as well as advancements in patient management protocols to enhance the safety of immunotherapeutic treatment.\nAdditionally, SITC 2018 will help strengthen the recent and rapid momentum concerning cell-based immunotherapies that have demonstrated remarkable success in treating patients with blood cancers. On Friday, Nov. 9, Nicholas Restifo, MD (National Cancer Institute), will discuss what the future of cellbased immunotherapies may look like in his keynote presentation, “NextGen Cell-based Immunotherapies.” On Saturday, Nov. 10, Philip D. Greenberg, MD (Fred Hutchinson Cancer Research Center), the 2018 recipient of the Richard V. Smalley, MD, Memorial Award and Lectureship, SITC’s highest honor, will discuss efforts toward expanding cell-based immunotherapies as an option for all cancer patients in his keynote presentation, “Engineering T cells to Effectively Target Tumors and Overcome Obstacles to Achieving Tumor Eradication.”\n“Research presented at SITC 2018 will showcase single-agent and combination treatments that have the potential to further improve outcomes for cancer patients, as well as exciting pre-clinical data that give insights into the mechanisms of tumor immunity and could lead to new agents and approaches in the clinic,” said SITC Incoming President Mario Sznol, MD, who is also Chair of the SITC Annual Meeting Program Committee. “The data presented at SITC 2018 will further highlight how the collaboration between pre-clinical and clinical science can continue to shape the future of immune therapies and increase patient response across the spectrum of malignancies.”\nOnline registration is open until Nov. 1, 2018, at 11:59 p.m. PDT. Onsite registration is also accepted. To learn more about SITC 2018, review late-breaking and regular abstract titles and more, please visit the SITC 2018 Annual Meeting website. The SITC 2018 regular abstract supplement will be published online in the Journal for ImmunoTherapy of Cancer (JITC), the society’s official open access, peer-reviewed journal, on Tuesday, Nov. 6, 2018 at 8 a.m. EST.\nEstablished in 1984, the Society for Immunotherapy of Cancer (SITC) is a nonprofit organization of medical professionals dedicated to improving cancer patient outcomes by advancing the development, science and application of cancer immunotherapy and tumor immunology. SITC is comprised of influential basic and translational scientists, practitioners, health care professionals, government leaders and industry professionals around the globe. Through educational initiatives that foster scientific exchange and collaboration among leaders in the field, SITC aims to one day make the word “cure” a reality for cancer patients everywhere. Learn more about SITC, our educational offerings and other resources at sitcancer.org and follow us on Twitter, LinkedIn, Facebook and YouTube.\n# # #", "label": "Yes"}
{"text": "Mem Inst Oswaldo Cruz, Rio de Janeiro, VOLUME 115 | JUNE 2020\nThe impact of imported malaria by gold miners in Roraima: characterizing the spatial dynamics of autochthonous and imported malaria in an urban region of Boa Vista\n1Universidade Federal de Roraima, Boa Vista, RR, Brasil\n2Secretaria de Saúde de Roraima, Coordenação Geral de Vigilância em Saúde, Boa Vista, RR, Brasil\n3Secretaria de Vigilância em Saúde do Ministério da Saúde, Brasil\n4Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brasil\n5Temple University, Institute for Genomics and Evolutionary Medicine, Department of Biology, Philadelphia, PA, United States of America\n6Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Imunoparasitologia, Rio de Janeiro, RJ, Brasil\nBACKGROUND The number of malaria cases in Roraima nearly tripled from 2016 to 2018. The capital, Boa Vista, considered a low-risk area for malaria transmission, reported an increasing number of autochthonous and imported cases.\nOBJECTIVES This study describes a spatial analysis on malaria cases in an urban region of Boa Vista, which sought to identify the autochthonous and imported cases and associated them with Anopheles habitats and the potential risk of local transmission.\nMETHODS In a cross-sectional study at the Polyclinic Cosme e Silva, 520 individuals were interviewed and diagnosed with malaria by microscopic examination. Using a global positional system, the locations of malaria cases by type and origin and the breeding sites of anopheline vectors were mapped and the risk of malaria transmission was evaluated by spatial point pattern analysis.\nFINDINGS Malaria was detected in 57.5% of the individuals and there was a disproportionate number of imported cases (90.6%) linked to Brazilian coming from gold mining sites in Venezuela and Guyana.\nMAIN CONCLUSIONS The increase in imported malaria cases circulating in the west region of Boa Vista, where there are positive breeding sites for the main vectors, may represent a potential condition for increased autochthonous malaria transmission in this space.\nMalaria continues to be a significant public health problem worldwide, causing about 228 million new cases, with approximately 405,000 deaths per year, especially in Africa.(1) Although the global incidence rate decreased by 18% between 2010 and 2016, there was a substantial increase between 2014 and 2015 in the Americas, primarily due to a surge of malaria cases in Brazil and Venezuela.(2) In Brazil, the number of malaria cases increased from 143,748 in 2015 to 193,837 in 2018 after seven years of decline, and in Venezuela (Bolivarian Republic of Venezuela) increased from 91,918 in 2015 to 414,527 in 2017, mainly in the Bolivar State in the southeast of the country bordering with Guyana and the Brazilian State of Roraima.(3) Also, the region has gold mining areas where working and living conditions are considered a problem for malaria control. Indeed, Bolivar State is a regional hot-spot from which malaria has spilled over to other neighboring countries overloading health care services in border municipalities of Brazil and Colombia that receive imported cases of malaria, including Plasmodium falciparum.(4)\nRoraima is the Brazilian State in the extreme north of the country that shares international borders with Guyana and Venezuela. In that space, human mobility across borders was usually intense but temporary. However, since 2017, Roraima has experienced the impact of an unprecedented unidirectional migration of Venezuelans due to the economic and political crisis in their country.(3) According to UNICEF and migration authorities in Brazil, an estimate of 178,000 Venezuelans has crossed into Roraima, with at least 32,000 settlings in Boa Vista, the State capital, located approximately 100 km distant from Guyana and 200 km from Venezuela.(5) Certainly, the increase in border population movements between Brazil, Venezuela, and Guyana have affected malaria control measures and contributed to the spread of the disease in Roraima State.(6)\nData from the Ministry of Health, SIVEP-Malaria (Epidemiologic Surveillance Information System ― Malaria), show that the number of reported cases in Roraima nearly tripled from 8,969 cases in 2016 to 23,369 in 2018.(7) Malaria is endemic in many municipalities which have various degree of endemicity. However, 39% of the cases were imported from other states in Brazil (3,625 cases) and other countries (5,513), mainly from Venezuela (4,478 cases) and Guyana (610 cases).(10) P. falciparum infections accounted for 26% of the imported and 9.8% of the autochthonous case.(7)\nBoa Vista is the municipality reporting most of the malaria imported cases from neighboring countries. In 2010 the number of reported cases were 5,948 and only 6% were autochthonous.(7) In 2011, the number of imported cases dropped to 4,354 and the autochthonous to 248 cases. This tendency to fall was maintained until reaching its lowest value in 2016, with about 2,357 imported cases and 12 autochthonous. However, in the years 2017 to 2018 there was a new increase in imported cases.(7)\nIn 2018, Boa Vista reported 5,713 cases, 168 (3%) autochthonous, 2,805 (49%) imported from other municipalities/states in Brazil, and 2,740 (48%) from other countries, mainly Venezuela (n = 2,115) and Guyana (n = 533). It is also noteworthy that, in 2018, cases of P. falciparum infection from Venezuela (n = 481) and Guyana (n = 97) represent 80% of the notifications of P. falciparum registered in Boa Vista (722 cases).(7) Studies of malaria vectors in Roraima performed more than ten years ago found that Anopheles albitarsis and An. darlingi were infected with Plasmodium spp.(8, 9)\nDespite being considered a low-risk area for malaria transmission, the consistent numbers of imported malaria cases, which are a possible source of infection, together with the presence of competent vectors in urban areas, make possible outbreaks and epidemics in Boa Vista.(10) A sustained increase in local transmission would be a significant setback for malaria elimination efforts in Boa Vista.\nConsidering the multiple factors that may drive the increase in malaria observed in Brazil, disentangling their differential contribution will guide how to better deploy interventions. Therefore, this study aimed to understand the epidemiology of the imported malaria cases and the potential risk of increased transmission in an urban region of Boa Vista.\nSUBJECTS AND METHODS\nStudy site - The study was carried out in Boa Vista, Roraima State, the only Brazilian State capital located entirely in the northern hemisphere, between Latitude 02º49’12” N and Longitude 60º40’23”W. Boa Vista occupies an area of 5,687,037 Km2, concentrates 63.4% of the state’s population and has a demographic density of 49.99 inhabitants per Km2 (Instituto Brasileiro de Geografia e Estatística - IBGE, 2016). Savanna is the predominant ecological environment in Boa Vista and the climate presents two distinct seasons: a rainy season between April and November with high rainfall indices during the months of June and July and the dry season between December and March. The geographical position of the municipality allows easy access to international borders thus positioned: in the north part of the state in the municipality of Pacaraima, which borders Santa Elena do Uairén in Venezuela, 231.5 km from Boa Vista, a land route (BR- 174). The municipality of Bonfim bordering Lethem, Cooperative Republic of Guyana, 133.3 km from Boa Vista via BR-401. To the South, the State is bordered by Amazonas State and Pará, Fig. 1.\nStudy population and sample collection - Samples and research data were collected from March 2016 to September 2018 at the Polyclinic Cosme e Silva. It is a health unit of the Unified Health System (SUS) that has a high demand for various medical specialties. This Polyclinic is strategically located in the west area of the city of Boa Vista, which has a population of 152,062 inhabitants (IBGE - 2016), distributed in 33 (thirty-three) neighborhoods. According to data from Ministry of Health, SIVEP - Malaria, among the 13 health units that offer malaria diagnosis in Boa Vista, the Polyclinic was the one that registered the highest number of cases in the last 5 years, as follow: in 2011, 2,354 cases; in 2012, 1,424 cases; in 2013, 1,713 cases; in 2014, 1,384 cases; and 966 cases in 2015.(10) Taking in account the total number of reported cases in Boa Vista in the same period (2011-2015), the Polyclinic Cosme e Silva was responsible for 51%, 44%, 42%, 54% and 48.8% of the reported cases, respectively.(7) Therefore, all individuals seeking a malaria diagnosis in the Public Health Unit Polyclinic Cosme e Silva, were eligible to participate in the study.\nA questionnaire, completed by each participant, was used to collect demographic data, travel history, and epidemiological data. Blood was drawn from each participant by venipuncture and malaria infection was diagnosed by microscopic examination of Giemsa stained blood smears. The parasitological evaluations were performed by examination of 200 fields at 1,000-fold magnification under oil immersion. Parasite densities were estimated by counting the number of parasites per microliter of blood (all species and stages) per 200 leukocytes in thick blood films, multiplying this by the number of individual leukocytes, and dividing this by 200.\nAll positive individuals were treated with antimalarial drugs, according to the protocol of the Brazilian Ministry of Health. All the questionnaire data were stored in Epi Info™ 2002 (CDC, Atlanta, GA, USA). This protocol was approved by the Federal University of Roraima Ethical Committee (CAAE: 44055315.0.0000.5302).\nCase definition - All malaria cases were classified as autochthonous or imported depending on the most likely place of acquisition as per the questionnaire. In this study, imported malaria was defined as malaria acquired outside the municipality of Boa Vista but diagnosed within the municipality. This was determined by the individual history of staying in an endemic municipality, state or country during the last one month. Autochthonous cases were defined as malaria acquired in the municipality of Boa Vista in persons without travel history outside the municipality in the last one month.\nBreeding sites and larval collection - Twenty-three breeding sites were identified and georeferenced using Garmin GPS by technicians of the entomology service of the General Coordination of Health Surveillance of Roraima. The breeding sites were chosen based on the location of autochthonous cases in previous 3 years (2014 to 2016). These breeding sites have been monitored by the entomology service of the General Coordination of Health Surveillance every two months between 2017 and 2018 and only qualitatively classified as positive or negative for the presence of Anopheles spp larvae. The larvae collections were performed using standard entomological scoops (BioQuip, Ranch Dominguez, CA, USA). At each breeding site, nine scopes were made, three to the right, three to the front, and three to the left, following the Ministry of Health standard.(10) Due to the great difficulty in rearing Anopheles larvae stage in the laboratory, Anopheles larvae from 1st and 2nd was used to determine if the breeding place were positive for Anopheles spp. Larvae (third and fourth-instar) and adults were identified using the keys of Consoli and Lourenço-de-Oliveira and Forattini.(11, 12) The larvae collected were transferred to plastic bags, labeled with the breeding site code, date and collector. All collected material was transferred to the state entomology laboratory to be screened and identified. The breeding site was considered positive if in at least one collection per year presented Anopheles spp larvae.\nSpatial analysis - The spatial dynamics of malaria in Boa Vista were analysed considering three situations: mapping of individuals with malaria, positive breeding sites for Anopheles and circulation time between first symptoms and treatment initiation. To perform spatial analysis, the locations of disease occurrence was recorded based on the address of malaria patients (Street and Neighborhood) and geographic coordinates were obtained, in decimal degrees geographic coordinate system, via Google Maps geographic location service.\nThe data were processed in the QGIS 2.14.17 software, executed from the Windows platform, to generate maps.\nThe basic cartography set was georeferenced using the decimal degrees geographic coordinate system and the World Geodetic System-1984 reference system (WGS84). All geographic data were processed in the Landscape Metrics Laboratory of the Department of Geography of the Federal University of Roraima (UFRR), which has available satellite images and cartographic basis of Boa Vista for the preparation of thematic maps.\nStatistical analysis and spatial point pattern analysis - Demographic, epidemiological and parasitological data were entered into a database created using the Epi Info software (Epi Info™, Atlanta, GA, USA). For statistical purpose, the following variables were taken into consideration: gender, age, residence, nationality, occupation, place of infection, symptoms, days since first symptoms and past and present malaria infections. Proportions were compared using 2x2 contingency tables with either chi-squared tests, adjusted by Yates’ continuity correction or Fishers exact tests, as appropriate. Odds ratios (OR) analysis were used to quantify the strength of the association between variables. The statistical significance threshold was p < 0.05, with 95% confidence intervals (95% CI) for all hypothesis tests. These analyses were performed using GraphPad InStat, version 3 (GraphPad Software, San Diego, CA, USA).\nKolmogorov-Smirnov test was used to verify the hypothesis of risk for malaria transmission in the western region of Boa Vista due to the existence of breeding sites and individuals with imported malaria, part of which with gametocytes. This test was applied in order to assess whether the distribution of the points follows a homogeneous Poisson process or whether the points are distributed according to a clustering model. For the interpretation of the values, consider a 5% level of significance in the results (95% CI). In summary, the null hypothesis to be tested is that the distribution of points throughout the region under study follows a homogeneous Poisson process.(13, 14)\nIn order to verify the hypothesis of complete spatial randomness, the analysis of specific processes was carried out by evaluating the graph of the G, F, K and L functions, to verify whether the points are distributed randomly or in the form of grouping throughout the region under study. The G function represents the distance from the nearest event (breeding sites, malaria and gametocytes cases), the plotted results of this function can be used as an exploratory method to check if there is evidence of interaction between the events; F function aims to check the risk rate, since it measures the distribution of all distances from an arbitrary point (cases, breeding sites and gametocytes) to the point closest to it; the K function represents the Ripley’s function, that allows the detection of the spatial pattern at different distance scales simultaneously; while the L function consists of the Besag transformation function of the Ripley’s function.(15) In the horizontal axis of the graphs it is shown distances between the points (individuals with malaria, breeding sites and gametocytes), so that in the vertical axis we have the density values based on the estimators of the functions G, F, K and L, respectively. The black lines mean the observed values, while the red lines correspond to the theoretical values of the function. The gray value range consists of the 95% CI, considering 99 simulations. The analyzes were performed using the software R v. 3.6.2.\nCharacteristic of the studied population - During the study period, 520 individuals participated in the study, 299 (57.5%) were positive for Plasmodium in the thick blood smear. The characteristics of the study population are presented in Table I. The majority of the individuals were male (74.6%), the mean age was 36 years and the nationality was predominantly Brazilians with permanent residence in Boa Vista, Roraima State. However, their main occupation was gold mining or mining activities in Venezuela and Guyana. Overall, 468 individuals declared a history of malaria episodes (90%); the majority reported more than five episodes (74.4%) and 10% did not recall past infection in their lifetime. Ninety-six percent of the asymptomatic individuals (n = 19), 68.4% had a positive diagnosis for malaria while 31.6% were negative. No difference was observed in the nationality, place of residence, occupation, and number of malaria episodes in the last three years between positive and negative individuals. However, proportion of malaria positives individuals decreases in the age groups 36-44 (OR = 0.59, 95% CI 0.35 - 0.98; p = 0.04) and > 44 (OR = 0.36, 95% CI 0.21 - 0.6; p < 0.01), as compared to groups of younger ages.\nBreeding sites - Boa Vista is located in an area with large rivers, streams and lakes, characteristics that favors the existence of breeding sites, in addition to the climate favorable to the presence of the main malaria vectors. The breeding sites were lakes, streams and natural permanent rivers, partially shaded and sunny with the presence of marginal vegetation, mainly in the dark and still waters. All 23 breeding sites mapped mostly murky and standing waters. All 23 were larval habitats for Anopheles spp larvae. An. darlingi and An. albitarsis were the species found in all investigated breeding sites, however, other species were as also found, An. Nuneztovari s.l., An. Mattogrossensis, An. Triannulatus and An. Evansae.\nAutochthonous and imported malaria cases - Of the 299 individuals positive for malaria infection during the studied period, 294 (98.3%) were imported and only five (1.7%) were autochthonous from the municipality of Boa Vista. Among these 172 were infected with P. vivax, 109 with P. falciparum, and 13 with mixed (P. falciparum + P. vivax). P. vivax was the most prevalent Plasmodium species found in 100% of the autochthonous cases and 57.5% of the imported cases. The observed P. falciparum and mixed (P. falciparum + P. vivax) infections were imported, Table II.\nBrazilian were the majority of the cases (94.6%) followed by Venezuelan (5.1%) and Guyanese (0.3%). A large number of the imported cases were acquired in Venezuela (58.8%) and Guyana (32.3%). The cases from French Guyana and Suriname corresponded to 1%) and 7.7% came from other municipalities of Roraima or other states in Brazil. Individuals with P. falciparum had, on average, a greater parasitemia than individuals affected by P. vivax and mixed infections. On average patients infected with P. falciparum and/or mixed infections sought diagnosis after about five days of onset of symptoms.\nSpatial distribution of infecting malaria species and vectors - The available addresses of 271 imported and five autochthonous cases were used to plot the spatial distribution of the cases by species, Fig. 2. Only two out of five autochthonous P. vivax cases reported their residence; the other three reported the place of infection as the neighborhood where they work. All individuals reported not leaving the municipality in the last 1 month.\nA radius of 1 km was established from the identified breeding sites as the mosquito’s flight coverage area (green region of the map).(16, 17) An area at risk of malaria transmission was delimited on the map (pink region of the map) considering the location of autochthonous and imported cases and their spatial relations with the breeding sites. In Fig. 2, the majority plotted points were of P. vivax malaria (151 imported and five autochthonous), P. falciparum malaria corresponds to 88 georeferenced points, while 32 points on the map represent mixed malaria. The map includes the 23 georeferenced breeding sites in the city. We observed that the majority of cases were concentrated in the west of the city. Several breeding sites were also observed in the east side of the city (green area in Fig. 2).\nSpatial distribution of gametocytes carriers and breeding sites - The residence of individuals positive for gametocyte forms of P. falciparum and P. vivax and their relationship with breeding sites was plotted, Fig. 3. We observed that gametocyte positive individuals were found within the radius of action of the Anopheles established at 1 km (green area) from the larval collection points in the streams and rivers positive for both An. darlingi and An. albitarsis. The highest concentration of these individuals was in the south and west of the municipality. The latter has the largest number of neighborhoods, 33, and it is the most populous with 152,062 inhabitants. Most of these neighborhoods are in the city outskirts and are within the breeding places range (pink color on the map of Fig. 3). Noteworthy, 73% of the gametocyte’s carriers sought treatment 48 h after the symptoms had started and these individuals were living in areas at risk of malaria transmission (pink color on the map) in several districts of Boa Vista, including the most populous zone of the municipality.\nRisk of local malaria transmission - According to the test results [Kolmogorov-Smirnov = 0.2376 (p-value < 0.001 in 95% CI)], there are specific locations that tend to have a higher frequency of malaria cases. It is to say that the circulation of individuals with malaria along the west zone of the municipality of Boa Vista increases the risk of malaria transmission.\nResults in Fig. 4 (G function) show that the observed values, that is, the distance between the cases of malaria and individuals carrying gametocytes from breeding sites (black line), are outside and above the confidence interval given by the gray area. Therefore, the circulation of individuals with the disease close to breeding sites is a risk factor for local malaria transmission. Analysis in a wider area, Fig. 4 (function F), the observed values, that is, the risk rate (black line), are outside and below the confidence interval given by the gray area. Thus, by the behavior of the function graph, the presence of individuals with malaria in this part of the municipality poses risk of local malaria transmission. Indeed, in Fig. 4. The reduced second order measures (K and L functions), endorse risk of local malaria transmission indicated in function G and K. Therefore, the spatial distribution and proximity of malaria cases, individuals carrying gametocytes and malaria vector breeding sites favors local malaria transmission.\nRoraima State has suffered an increase in the number of malaria cases. Its capital, Boa Vista, is the municipality with the highest number of imported cases in the State.(3) Imported malaria is considered a critical impediment to elimination in many countries including Brazil. Indeed, this study shows that most of the cases reported in the Health Unit in the urban area of Boa Vista, during the time of this study, were imported from Venezuela (58.8%) and Guyana (32.3%) with only few autochthonous cases (1.7%), as previously observed.(7) Autochthonous infections were all P. vivax while imported infections were attributed mainly to P. vivax and to a lesser extent to P. falciparum. Despite its relatively low number, falciparum/vivax mixed infections were detected in the study’s site. Moreover, the vast majority of these imported cases (90.4%) were Brazilians coming from gold mining sites (90.4%) in Venezuela and Guyana rather than migrants from these countries. Overall, gold miners are at higher risk of contracting malaria making them a “hot pop” or subpopulation at higher risk of Plasmodium infection.(18)\nBrazilian miners spend part of their time between the gold mines abroad and Boa Vista, where they live (98.3%) and sell the products of this labor, generating high mobility between endemic areas in Venezuela and Guyana to Boa Vista. Indeed, the massive flow of miners in this health unit reflects the high risk of malaria in the mining sites.(7, 19) Consistent with these observations, imported malaria in recent years has increased exponentially as gold mining activities increase in 2018 and gold was the second most exported product in the state.(19, 20, 21) There are currently 1,097 illegal mining points located in Venezuela, Guyana and Brazil (Yanomami indigenous lands) producing high mobility of job seekers.(22) Although these mining regions are generally unhealthy and dangerous, it provides an economic incentive that motivates the return of these individuals in search of survival, while still at risk of malaria. Overall, the situation observed in Roraima is consistent with reports emerging from other endemic areas in the Americas.(23, 24)\nResults from our study indicate that there are several positive breeding sites for An. darlingi and An. albitarsis in Boa Vista. Also, we found asymptomatic individuals (4.3%) and the “time to start treatment of patients after the date of first symptoms” was over 48 h for 60% of patients. These factors could increase the risk of local transmission after malaria has been introduced. This situation requires increasing surveillance as evidenced by an increase of 1.300% in autochthonous cases in Boa Vista in 2018.\nImportantly, the Boa Vista health services attract migrants from other municipalities and border cities seeking malaria treatment and the location of the city favors the movement of people and goods. These characteristics create a continuous flow between the mining areas and Boa Vista. The relationship between people’s mobility and imported malaria has been pointed out in several studies as a concern for malaria control and elimination. In this case, mobility is linked to gold miners.\nThe risk of local malaria transmission observed by the spatial point pattern analysis, even if it is limited to an area of Boa Vista, deserves attention from health surveillance agencies, as it is a populous area where most neighborhoods are concentrated, in addition to housing farms and water collection. It is possible that this risk may extend to other areas of the city given the similarity of the characteristics observed in the urban and peri-urban perimeter of the municipality. Therefore, the expansion of this study to other areas of the city is important in order to assess this risk for the city of Boa Vista as a whole.\nIn Boa Vista, during the study period, the main malaria control measures were passive case detection and treatment and other measures follow a specific demand focused on the occurrence of autochthonous cases. Active case detection of infected individual’s, insecticide spraying of households and health education are limited to the probable place of infection of confirmed autochthonous case and neighborhood. Occasionally, identification of breeding sites and Anopheles larvae collection are performed. Therefore, implementation of control measures to reduce the risk of autochthonous transmission such as continuous surveillance of active case detection, monitoring Anopheles breeding sites associated with insecticide spraying of households and health education targeting the hot pop, especially gold miners should be strongly considered in Boa Vista.(25, 26)\nIt is worth noting that we did not observe any autochthonous P. falciparum infections, although our number was low (n = 5). However, data from the Ministry of Health, SIVEP-Malaria have indicated 14 P. falciparum imported cases in Boa Vista in the last three years.(7) Imported P. falciparum cases present an unusual distribution in other studies, affecting about two out of five individuals examined, a cause for concern as there is a risk of introducing and spreading P. falciparum resistant strains from neighboring countries in Brazil.(27, 28) In a macro-policy scenario, advocated by the Ministry of Health, through the elimination plan, Brazil aims to eliminate falciparum malaria by 2022.(28)\nThere is no bilateral cooperation between Brazil and Venezuela such as that between Andean countries (Venezuela, Peru, Colombia, and Ecuador) for malaria containment.(28) However, since Brazilians miners are the ones introducing malaria, this may reveal weaknesses in border control measures, and poses a challenge for malaria control and, particularly, for P. falciparum elimination goals. Given the relatively good communication between Bolivar State and Roraima, and the gold mining activities in Bolivar State, the Brazilian-Venezuelan border could be regarded as a malaria corridor where the disease will likely remain resilient to uncoordinated control efforts across international borders.(29)\nThe data reported in this research are important, however limited, as they represent only a certain area of the city of Boa Vista. In this study, participation of Brazilians with malaria was significantly higher than Venezuelans, with the majority of imported malaria coming from the mining region. As this study was limited to just one health unit, it is possible that other health centers provided assistance to Venezuelans with malaria.\nDespite this limitation, it is important to note that in regions with low malaria transmission, the distribution of autochthonous cases has become more and more irregular and heterogeneous, capable of modifying local epidemiology, as observed by the increase of autochthonous cases in Boa Vista (1.300%).\nIn conclusion - Imported malaria in an urban area of Boa Vista is driven by Brazilians working on gold mines traveling across international borders. It seems that the origin of imported malaria in the west region of Boa Vista is related to mining and not to the migratory movement. Regardless of the motivation, malaria represents the universe of individuals at social risk. Despite the low number of autochthonous cases, the influx of imported infected travelers into areas with suitable vectors breeding sites, there is a potential risk for an increase in autochthonous malaria in the studied area, including the risk of introducing P. falciparum malaria. Therefore, early detection of malaria cases is necessary to limit their potential negative impact in achieving the goals of elimination plan proposed by the Brazilian Ministry of Health.\nTo Rispah Abdhallah, Naomi W Lucchi, and Venkatachalam Udhayakumar, CDC. We thank Pedro Rufino da Silva, Valdenor Alves Macedo and Cleomar Oliveira da Silva for assistance with the breeding places mapping and Secretary of Health of Roraima ― General Coordination for Health Surveillance for fieldwork support.\nJOF, JL and AAE conceived the idea and participated in the study design; JL, NCVA and JLPA were responsible for sample collection; JOF, JL, NCVA, JLPA, TMC, JC carried out the experiments and analysed the data; JOF, JL and TMC drafted the manuscript and JOF and AAE revised. All authors read, corrected and approved the final manuscript. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.", "label": "Yes"}
{"text": "Development of the mammary gland requires the coordinated action of proteolytic enzymes during two phases of remodelling. Firstly, new ducts and side-branches thereof need to be established during pregnancy to generate an extensive ductal tree allowing the secretion and transport of milk. A second wave of remodelling occurs during mammary involution after weaning. We have analysed the role of the cell surface protease aminopeptidase N (Anpep, APN, CD13) during these processes using Anpep deficient and Anpep over-expressing mice. We find that APN deficiency significantly delays mammary gland morphogenesis during gestation. The defect is characterised by a reduction in alveolar buds and duct branching at mid-pregnancy. Conversely over-expression of Anpep leads to accelerated ductal development. This indicates that Anpep plays a critical role in the proteolytic remodelling of mammary tissue during adult mammary development.", "label": "Yes"}
{"text": "Automated amplicon design suitable for analysis of DNA variants by melting techniques\nBMC Research Notes volume 8, Article number: 667 (2015)\nThe technological development of DNA analysis has had tremendous development in recent years, and the present deep sequencing techniques present unprecedented opportunities for detailed and high-throughput DNA variant detection. Although DNA sequencing has had an exponential decrease in cost per base pair analyzed, focused and target-specific methods are however still much in use for analysis of DNA variants. With increasing capacity in the analytical procedures, an equal demand in automated amplicon and primer design has emerged.\nWe have constructed a web-based tool that is able to batch design DNA variant assay suitable for analysis by denaturing gel/capillary electrophoresis and high resolution melting. The tool is developed as a computational workflow that implements one of the most widely used primer design tools, followed by validation of primer specificity, as well as calculation and visualization of the melting properties of the resulting amplicon, with or without an artificial high melting domain attached. The tool will be useful for scientists applying DNA melting techniques in analysis of DNA variations. The tool is freely available at http://meltprimer.ous-research.no/.\nHerein, we demonstrate a novel tool with respect to covering the whole amplicon design workflow necessary for groups that use melting equilibrium techniques to separate DNA variants.\nFriedrich Miescher discovered the nucleic acid in 1868–69 (reviewed by R. Dahm) [1, 2]. This may be defined as the starting point of a research field that has expanded into a huge area of medical and biological research. Many important methodological advances have been made in order to facilitate analysis of DNA. The polymerase chain reaction (PCR), first published by Kleppe et al. , which opened for mass amplification of DNA amplicons, is still a key method in modern molecular analysis of DNA. PCR amplification has the ability to amplify specific target sequences, as well as whole genomes up to a factor of 1011. In 1977, a DNA sequencing approach introduced by Sanger used dideoxy nucleotides to terminate enzymatic amplification of single stranded DNA . This method was refined and eventually used to sequence almost the entire human genome. PCR amplification and Sanger sequencing, and variations of these core techniques, are still very important parts in present day DNA research. Following the development of these and other molecular methods, techniques enabling separation and visualization of amplified DNA have taken place, from the starting point of using radioactively labeled DNA and gel electrophoresis, through laser-induced fluorescence capillary electrophoresis, until various high throughput-sequencing platforms with the capacity to determine up to 5G bases/day.\nOne set of methods that was developed to detect unknown DNA variants was based on differential migration velocities of mutant single-stranded sequences or wild type/mutant heteroduplexes drawn through a macromolecular matrix by an electric field [5–7]. Of these, denaturing gel electrophoresis when performed in capillaries (constant denaturing capillary electrophoresis, CDCE) under optimized conditions has been demonstrated to comprehensively detect any point mutation, including single base insertions and deletions, in target sequences of ~70–140 bp [8, 9]. Methods employing CDCE have been reported with sensitivities to detect and identify mitochondrial and nuclear point mutations at levels at or above 2 × 10−6 mutations per gene copy in human cells, tissues and pooled blood samples [10–12]. Under a given concentration of chemical denaturant, such as urea, multiple capillary runs were required to define the generally narrow temperature range (~0.1 °C) that would separate heteroduplexes containing any of a wide variety of single deletion or single substitution mutants from wild type homoduplexes. CDCE has been adapted to commercial multi-capillary instruments, thus increasing the throughput of the method [13, 14]. A second improvement of the method was the introduction of oscillating temperature. By rapidly changing the denaturing condition in the capillaries, multiple DNA target sequences could be scanned simultaneously in the same run [13, 15–17]. One limitation of melting gel techniques results from DNA sequences rich on GC content, which can lose the resolution power due to complete strand dissociation at elevated temperatures. However, data from the complete melting map of the human genome indicates that the melting gel method can be applied to about 90 % of the human genome . Because melting gel techniques are still much in use (more than 700 articles published in 2013), we have created a computational workflow that selects PCR primers , validates primer specificity in the genome of interest , and computes the DNA melting profile  with an artificial high temperature melting domain . This web application, which is embedded in the Galaxy framework [23–25], will simplify amplicon design and increase the throughput of the method when amplicons are analyzed in multi-capillary instruments. Additionally, the amplicons designed in this web application, are also suitable for high resolution melting. This is a method that emerged after the introduction of thermocycler with fluorescent detection systems enabling visualization of the PCR amplification of DNA in real-time [26–30].\nResults and discussion\nThe amplicon design interface is available at the following URL: http://meltprimer.ous-research.no/. Currently, the Variant Melting Profile tool supports design for DNA variants in the human genome (hg19) and the mouse genome (mm10). Upon request to the authors, additional genomes from other organisms can be added to the server. We have used the human genome as a model to test the Variant Melting Profile tool. The tool can run in single or batch mode, depending on the need to design amplicons for a single variant or a set of variants. There are two ways of entering variants of interest, either by using dbSNP reference IDs (e.g. rsIDs), or by specifying custom positions using a chromosome number, base pair position on the specific chromosome, and entering the relevant reference and variant alleles manually (chromosome:position:reference_allele:alternative_allele). An example of valid input is shown in Fig. 1. The lower variants entered in Fig. 1 demonstrate the two different ways of presenting the same genomic position. The resulting primers for these two ways of entering will be identical. The default values in the interface comprise standard primer length, annealing temperatures range and amplicon length intervals. These settings can be adjusted as needed. Depending on the allele discrimination method to be used downstream from the design, a high-temperature melting domain (GC-clamp) can be added to amplicons of interest. The GC-clamp is selected through a drop-down menu (Fig. 1). After the genomic position or reference numbers have been entered in the entry field, the workflow checks each position towards the latest build provided by NCBI. Un-recognized rs numbers will be called invalid and must be checked by the user, and invalid rs numbers must be removed prior to execution of the workflow. The execute button will start the selection of primers using Primer3, which is the most widely used open-source tool for selecting primers [19, 31]. From the primer list generated for each amplicon, the first candidate set is checked by an in silico PCR instance within the software for its specificity in the genome. Primer pairs resulting in more than one genomic region being amplified will be rejected. The column “ID” reports unspecific primers as “No primers found” (Fig. 2). The reason for this stringent setting is that amplicons with multiple hits in the in silico PCR are most likely to fail in the chemical PCR reaction. An example of a variant that will give multiple hits in the in silico PCR is chr9:66783838:C:T. The primers suggested, 5′AGACAGAAGCATTCTCAGGAACT3′ and 5′CCTGGTCTATCAAAAGAAAGGT3′, will result in 188 theoretical amplifications. Thus, the amplicon design tool rejected the primers and the amplicon.\nFrom the results list, useful information regarding amplicon length, sequence, mutation position and primer annealing temperature can be obtained. Figure 3 represents part of the results list when designing amplicons around variants in the TP53 gene (all data not shown). Of the 725 rs numbers in the input list, a total of 68 were found invalid and had to be removed before amplicon design could be performed. The computing time for primer selection, check of primer specificity, and melting curve calculation took 102 min for these amplicons combined. On average, one DNA melting assay is computed in 9.3 s. Importantly, manual design of primer sets is an error-prone process due to the large number of steps involved, especially in batch design settings. The default “orientation” of the GC-clamp is based on the amplicon melting profile. The clamp is simulated on the side of the amplicon with the highest average melting temperature, thus facilitating a decrease in melting temperature towards the side of the amplicon without the GC-clamp (Figs. 4, 5). Information on clamp position is found in the column “Clamp pos” (Figs. 2, 3). The melting temperature of amplicons with small insertions/deletions are always plotted from 5′–3′, with the GC-clamp positioned at the 5′ end. Consequently, the difference in melting profile of the deletion/insertion will be seen in the low melting domain and not in the GC-clamp (Fig. 4). The side is selected in such a manner that the melting temperature profile increases towards the GC-clamp. This is to avoid “dips” in the low temperature melting domain [16, 32], which would give peak broadening and loss of resolution. However, the tool also allows the user to determine the specific placement of the GC-clamp. As seen in Fig. 1, the drop-down menu for ‘GC clamp location’ has several options for placement of the GC-clamp: “none”, “automatic” (i.e. selecting the side with highest average melting temperature), “5-prime end” or “3-prime end”. This functionality will allow the user to explore the effect of the GC-clamp in relation to the melting behavior of the fragments. The result column “Avg Melt Temp” calculates the average melting temperature of the target sequence between the primers. When corrected for urea concentration in the polymer (−3 °C/1 M urea) [33, 34], this would yield the analysis temperature used in a capillary electrophoresis instrument. An example of the melting profile is shown in Fig. 4 and part of Fig. 5. The vertical line in the melting graph indicates the variant position (Figs. 4, 5, 6). The Google chart feature has sliders that allows the user to focus the graph at the X-axis (Fig. 5). A core feature of the Galaxy framework is that the results of each analysis are stored in a history. It is optional for the user to register an account that allows for storage of the amplicon design history (Fig. 1). An arbitrary variant (rs2252586) was used as a test on the amplicon design, subsequently followed by ordering of the suggested primers and analysis of the amplified amplicon by cycling temperature capillary electrophoresis and high resolution melting (HRM). The PCR reaction was optimized in a temperature gradient thermo cycler. The gradient used was from 52.2–60.2 °C. The optimal annealing temperature observed for this amplicon was approximately 4 °C lower than the theoretical value given in the results list, which is in accordance to general PCR protocols . Figure 5 depicts the clear baseline separation of the alleles in the amplicon. The single strand (X) is recognized as a distribution, in contrast to the double stranded target with appropriate melting properties. As previously demonstrated, single stranded DNA will not significantly alter its position in the electropherogram with changes in the denaturing conditions . To test the workflow further, primer sets for 2500 SNP reference numbers were also successfully designed in one run.\nFigure 6 illustrates the melting profile of the amplicon (rs2252586) without the GC-clamp. The difference in melting temperature of the alleles is exploited in the HRM assay. By slowly heating the PCR product and recording the fluorescence for each temperature increment, a temperature dependent decrease in the signal occurs due to strand dissociation [26–30]. After normalization of the data and subtraction of the values of a known reference, genotypes can be visualized as in Fig. 6, lower part. To further explore the HRM assay, a set of twelve rs numbers (Table 1) previously analyzed by CTCE (manuscript in preparation) were subjected to analysis with Variant Melting Profile (batch mode) with default settings and no GC-clamp. For each amplicon, eight samples were subjected to real time-PCR following HRM. Figure 7 displays the analysis of the melting curve data, normalized and plotted as differences to a known heterozygote sample. The data suggest that HRM could be used in 8 or 9 amplicons as a genotyping tool. It is noteworthy that one amplicon (rs1011970) failed due to a second SNP (rs188512825) in the fragment. However, with better temperature control, HRM could in theory resolve the allele combinations of two neighboring SNPs (micro-haplotypes), given that the variants changes the DNA melting properties sufficiently.\nThis is the first web application, to our knowledge, that combines the three features of primer selection around a DNA variant, controlling primer pair for specificity, and of computing the melting properties of the amplicon with or without a GC-clamp. Hence, this tool is novel with respect to covering the whole workflow necessary for groups that currently use melting equilibrium techniques to separate DNA variants.\nVariant melting profile\nThe Variant Melting Profile is served as a tool within the Galaxy framework, which is an open source, web-based platform for data intensive biomedical research [23–25]. Galaxy is here used in combination with components from the Genomic Hyperbrowser [36, 37] as well as Google Charts for visualization (https://developers.google.com/chart/).\nDNA variants (single nucleotide variants) can be given either as genomic coordinates (chromosome:position:reference_allele:alternative_allele), or as dbSNP reference IDs (e.g. rs9648696). User-specified parameters for selection of PCR primers (e.g. optimum primer sizes and primer melting temperatures etc.), as given by the Primer3 program  is used for finding suitable primers. The top candidate amplicon within the list of candidate primers is checked for specificity in the human genome using UCSC In-Silico PCR . If the amplicon maps uniquely, a GC clamp can be added to the PCR amplicon, and the DNA melting profiles for the nucleotide variants are visualized in an interactive fashion. The melting profiles are generated using the thermodynamic model provided by Blossey and Carlon .\nDNA extraction, amplification and CTCE\nGenomic DNA was extracted from anonymous blood donor samples by use of GenoVision M48 extraction robot (Biorobot M48 station, Qiagen, Norway), following standard procedures as given by the instrument manufacture.\nA 42 base pair sequence of dGTP and dCTP, also known as a GC-clamp, labeled with 6-FAM, was incorporated at one end of the amplified target using a set of three primers in the PCR setup. An amplicon was designed for analysis of DNA variation identified by NCBI SNP references number, rs2252586.\nReverse ½ GC-lamp tailed\nThe PCR reaction mixture contained approximately 5 ng/µl genomic DNA, 0.4 mM dNTPs (0.1 mM of each dNTP) (VWR, Oslo, Norway), 1X Taq buffer, 0.075unit Taq/µl, 0.15 µM each of labeled GC clamp and the 1/2 GC-clamp tailed primer, while 0.3 µM of the “forward” primer (Integrated DNA Technologies, Leuven, Belgium) and 3 mM MgCl in a total reaction volume of 10 µl. Amplification was performed in a Eppendorf Mastercycler ep gradient S (Eppendorf, Hamburg, Germany) cycling 35 time between the temperatures of; cycles of denaturation for 10 s at 94 °C, annealing at 55.7 °C for 20 s and elongation at 72 °C for 30 s.\nSix-fam labeled PCR products were analyzed with a 96-capillary DNA analyzer, i.e. the MegaBACE™ 1000 DNA Analysis System (GE Healthcare Life Sciences, Pittsburgh, PA, USA). The instrument was modified to allow for elevated temperatures up to 65 °C. For detailed information about the modification, please contact the author P.O. Ekstrøm. Standard sequencing polyacrylamide (MegaBACE LPA) containing urea was replaced in the capillaries prior to each run. Samples were loaded into the capillaries from 96-well plates by electrokinetic injection at 161 V/cm for 15 s. The electrophoresis was carried out at a constant field of 145 V/cm. Laser-induced fluorescence was used with excitation at 488 nm (blue laser) and detection of emission at 520 nm (FAM channel). The scan rate was 1.75 Hz. The optimal separation temperature proposed by these programs was adjusted based on the urea concentration in the matrix. For each molar increment of urea, the temperature was lowered approximately 3 K (Kelvin) [40, 41].\nThe denaturing temperature in the capillary chamber, the cycling temperature, was programmed in the macro.ini file used by the Instrument Control Manager (ICM) software package (GE Healthcare Life Sciences, Pittsburgh, PA, USA). Data were converted to text files by MegaBACE Sequence Analyzer View and Edit software.\nReal time-PCR and high resolution melting (HRM)\nA 25 µl Real time-PCR reaction was made up of 12.5 µl 2xMIX (PerfeCTa® SYBR® Green SuperMix, Quanta Biosciences, Gaithersburg, USA) 0.75 µl forward and 0.75 µl reveres primer with a concentration of 0.3 µM each. 2 µl DNA template and 9 µl H2O. The mixture was cycled 50 times with the following temperature, 95 °C for 15 s and 60 °C for 30 s. The fluorescence was read for each cycle, in a CFX Connect™ Real-Time PCR Detection System (Bio-Rad Laboratories AB, Oslo, Norway).\nHigh resolution melting was performed after the temperature cycling by slowly increasing the temperature from 65–95 °C in increments of 0.1 °C. Fluorescent signal was recorded for 5 s after each 0.1 °C increment.\nPrimers used for the real-time PCR and HRM were selected by the Variant Melting Profile tool, checked for specificity by ePCR ordered from IDTDNA, with the following base composition: “Reverse” primer 5′CAACACGTTTCACCAGTGCA3′ and “forward” primer 5′TGCAAGATTGTACCTTCCTTGGT3′.\nHRM curve data were normalized to the pre-melt (initial fluorescence) and post-melt (final fluorescence) signals. Thus, all samples were set to uniform, relative values from 100–0 %. The temperature axis of the normalized melting curves was shifted to the point where the entire double-stranded DNA was completely denatured. Differences in melting curve shape were further analyzed by subtracting the curves from a reference curve. We used a heterozygote sample as reference.\nFollowing the initial test of HRM, 12 fragments were automatically designed on SNPs with references number given in Table 1. The fragments were subjected to Real time-PCR and HRM as described above, save for the annealing temperature which was set to 57 °C.\nAvailability and requirements\nProject name: MeltPrimer\nProject home page: http://meltprimer.ous-research.no/\nOperating system(s): Linux\nProgramming language: HyperBrowser/Galaxy framework, SQLite, Blat/gfServer/gfPcr, Primer3\nAny restrictions to use by non-academics: no licenses needed.\nDahm R. Discovering DNA: Friedrich Miescher and the early years of nucleic acid research. Hum Genet. 2008;122:565–81.\nDahm R. Friedrich Miescher and the discovery of DNA. Dev Biol. 2005;278:274–88.\nKleppe K, Ohtsuka E, Kleppe R, Molineux I, Khorana HG. Studies on polynucleotides. XCVI. Repair replications of short synthetic DNA’s as catalyzed by DNA polymerases. J Mol Biol. 1971;56:341–61.\nSanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA. 1977;74:5463–7.\nAndersen PS, Jespersgaard C, Vuust J, Christiansen M, Larsen LA. Capillary electrophoresis-based single strand DNA conformation analysis in high-throughput mutation screening. Hum Mutat. 2003;21:455–65.\nGanguly A. An update on conformation sensitive gel electrophoresis. Hum Mutat. 2002;19:334–42.\nLi Q, Liu Z, Monroe H, Culiat CT. Integrated platform for detection of DNA sequence variants using capillary array electrophoresis. Electrophoresis. 2002;23:1499–511.\nKhrapko K, Hanekamp JS, Thilly WG, Belenkii A, Foret F, Karger BL. Constant denaturant capillary electrophoresis (CDCE): a high resolution approach to mutational analysis. Nucleic Acids Res. 1994;22:364–9.\nKhrapko K, Andre P, Cha R, Hu G, Thilly WG. Mutational spectrometry: means and ends. Prog Nucleic Acid Res Mol Biol. 1994;49:285–312.\nAndre P, Kim A, Khrapko K, Thilly WG. Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence. Genome Res. 1997;7:843–52.\nKhrapko K, Coller H, Andre P, Li XC, Foret F, Belenky A, et al. Mutational spectrometry without phenotypic selection: human mitochondrial DNA. Nucleic Acids Res. 1997;25:685–93.\nLi-Sucholeiki XC, Thilly WG. A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA. Nucleic Acids Res. 2000;28:E44.\nEkstrom PO, Bjorheim J, Gaudernack G, Giercksky KE. Population screening of single-nucleotide polymorphisms exemplified by analysis of 8000 alleles. J Biomol Screen. 2002;7:501–6.\nBjorheim J, Minarik M, Gaudernack G, Ekstrom PO. Mutation detection in KRAS Exon 1 by constant denaturant capillary electrophoresis in 96 parallel capillaries. Anal Biochem. 2002;304:200–5.\nEkstrom PO, Bjorheim J, Thilly WG. Technology to accelerate pangenomic scanning for unknown point mutations in exonic sequences: cycling temperature capillary electrophoresis (CTCE). BMC Genet. 2007;8:54.\nEkstrom PO, Khrapko K, Li-Sucholeiki XC, Hunter IW, Thilly WG. Analysis of mutational spectra by denaturing capillary electrophoresis. Nat Protoc. 2008;3:1153–66.\nKristensen AT, Bjorheim J, Wiig J, Giercksky KE, Ekstrom PO. DNA variants in the ATM gene are not associated with sporadic rectal cancer in a Norwegian population-based study. Int J Colorectal Dis. 2004;19:49–54.\nLiu F, Tostesen E, Sundet JK, Jenssen TK, Bock C, Jerstad GI, et al. The human genomic melting map. PLoS Comput Biol. 2007;3:e93.\nRozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol. 2000;132:365–86.\nHinrichs AS, Karolchik D, Baertsch R, Barber GP, Bejerano G, Clawson H, et al. The UCSC genome browser database: update 2006. Nucleic Acids Res. 2006;34:D590–8.\nTostesen E, Jerstad GI, Hovig E. Stitchprofiles.uio.no: analysis of partly melted DNA conformations using stitch profiles. Nucleic Acids Res. 2005;33:W573–6.\nMyers RM, Fischer SG, Maniatis T, Lerman LS. Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Nucleic Acids Res. 1985;13:3111–29.\nGoecks J, Nekrutenko A, Taylor J. Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Genome Biol. 2010;11:R86.\nBlankenberg D, Von KG, Coraor N, Ananda G, Lazarus R, Mangan M et al.: Galaxy: a web-based genome analysis tool for experimentalists. Curr Protoc Mol Biol 2010, Chapter 19: Unit-21.\nGiardine B, Riemer C, Hardison RC, Burhans R, Elnitski L, Shah P, et al. Galaxy: a platform for interactive large-scale genome analysis. Genome Res. 2005;15:1451–5.\nHardies SC, Hillen W, Goodman TC, Wells RD. High resolution thermal denaturation analyses of small sequenced DNA restriction fragments containing Escherichia coli lactose genetic control loci. J Biol Chem. 1979;254:10128–34.\nWittwer CT, Reed GH, Gundry CN, Vandersteen JG, Pryor RJ. High-resolution genotyping by amplicon melting analysis using LCGreen. Clin Chem. 2003;49:853–60.\nGundry CN, Vandersteen JG, Reed GH, Pryor RJ, Chen J, Wittwer CT. Amplicon melting analysis with labeled primers: a closed-tube method for differentiating homozygotes and heterozygotes. Clin Chem. 2003;49:396–406.\nGundry CN, Bernard PS, Herrmann MG, Reed GH, Wittwer CT. Rapid F508del and F508C assay using fluorescent hybridization probes. Genet Test. 1999;3:365–70.\nGibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res. 1996;6:995–1001.\nUntergasser A, Cutcutache I, Koressaar T, Ye J, Faircloth BC, Remm M, et al. Primer3—new capabilities and interfaces. Nucleic Acids Res. 2012;40:e115.\nHinselwood DC, Abrahamsen TW, Ekstrom PO. BRAF mutation detection and identification by cycling temperature capillary electrophoresis. Electrophoresis. 2005;26:2553–61.\nBjorheim J, Ekstrom PO, Fossberg E, Borresen-Dale AL, Gaudernack G. Automated constant denaturant capillary electrophoresis applied for detection of KRAS exon 1 mutations. Biotechniques. 2001;30:972–5.\nBjorheim J, Ekstrom PO. Review of denaturant capillary electrophoresis in DNA variation analysis. Electrophoresis. 2005;26:2520–30.\nInnis MA, Gelfand DH, Sninsky JJ, White TJ. PCR protocols—a guide to methods and applications. London: Academic press; 1990, p. 482. ISBN: 0-12-372181-4.\nSandve GK, Gundersen S, Johansen M, Glad IK, Gunathasan K, Holden L, et al. The Genomic HyperBrowser: an analysis web server for genome-scale data. Nucleic Acids Res. 2013;41:W133–41.\nSandve GK, Gundersen S, Rydbeck H, Glad IK, Holden L, Holden M, et al. The Genomic HyperBrowser: inferential genomics at the sequence level. Genome Biol. 2010;11:R121.\nKent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, et al. The human genome browser at UCSC. Genome Res. 2002;12:996–1006.\nBlossey R, Carlon E. Reparametrizing the loop entropy weights: effect on DNA melting curves. Phys Rev E Stat Nonlin Soft Matter Phys. 2003;68:061911.\nHutton JR. Renaturation kinetics and thermal stability of DNA in aqueous solutions of formamide and urea. Nucleic Acids Res. 1977;4:3537–55.\nKlump H, Burkart W. Calorimetric measurements of the transition enthalpy of DNA in aqueous urea solutions. Biochim Biophys Acta. 1977;475:601–4.\nPOE specified the underlying software components and was responsible for testing of the Variant Melting Profile tool. POE amplified DNA by PCR and separated variants. SN and MJ implemented the computational workflow underlying Variant Melting Profiles. EH participated in the design of the study. All authors contributed equally in the writing of the manuscript and have read and approved the final version. All authors read and approved the final manuscript.\nThis study was supported by Research Council of Norway Grants 221580 and 218241, and Grant 71220 -PR-2006-0433 from The Norwegian Cancer Society.\nThe authors declare that they have no competing interests.\nAbout this article\nCite this article\nEkstrøm, P.O., Nakken, S., Johansen, M. et al. Automated amplicon design suitable for analysis of DNA variants by melting techniques. BMC Res Notes 8, 667 (2015). https://doi.org/10.1186/s13104-015-1624-8", "label": "Yes"}
{"text": "REVIEW 3: NUTRITION, RESPIRATION & PHOTOSY/NTHESIS\nNUTRITION AND METABOLISM\nAll living organisms need energy and nutrients. The energy is used for many purposes, such as\nsynthesis → building more molecules\ngrowth → making new cells to grow larger\nrepair → making new cells to mend injuries\nlocomotion → moving around in the environment\nThe nutrients are also used for many purposes, such as\nraw materials → the building blocks that new molecules and cells are built from\nfuel → used to make energy in cell respiration\nAnimals have to eat food to both make energy and get nutrients. When animals take in food, it’s called ingestion. When they breakdown the food, it’s called digestion. When they take the food into their cells, it’s called absorption. Since they have to eat other organisms, animals are called heterotrophs. Hetero means “others”, troph means “feeding”, so heterotroph means\n“feeding on others”.\nSome organisms can harvest the energy from the sun and use it to synthesize the molecules and cells of their bodies. These organisms are plants. The process that allow plants to capture the sun and use it for synthesis is photosynthesis. Because, in this way, plants make their own food, they are also called autotrophs. Auto means “self”, troph means “feeding”, so autotroph means “self-feeding”. In photosynthesis, plants take in simple inorganic compounds (CO2 &\nH2O) and build organic nutrients such as sugars (C6H12O6)\n1. Nutrition: Organisms take in nutrients (food) for various activities including:\na. Ingestion: ______________________________________________________________\nb. Digestion: ______________________________________________________________\nNutrients must be broken down into smaller parts so that they can be\n________________________ into the blood and cells of organisms.\nStarches are digested into ______________________________________________\nProteins are digested into _______________________________________________\n1 of 6\n2. Autotrophic Nutrition:\na. Organisms take inorganic materials ( ______ & ______ ) and convert them into organic nutrients (__________________).\nb. Auto = ___________; troph = ___________ so Autotroph = _______________________\nc. What process do autotrophs use to do this? ____________________________________\nd. Examples of organisms that do this: __________________________________________\n3. Heterotrophic Nutrition:\na. Organisms must __________________ nutrients made by other organisms.\nb. Hetero = ___________; troph = ___________ so Heterotroph = ____________________\nc. Examples of organisms that do this: __________________________________________\nd. These organisms include:\n4. Write the formula for photosynthesis: chemical formulas\n5. Photosynthesis is the process in which sun’s energy is trapped in the chemical bonds of sugar. a. Requires _________________, _________________, and _________________.\nb. Makes _________________ (______________) which is used as food in the plant.\nc. Waste product produced is _________________.\nProvides food for all plants and animals → the whole food chain.\nProvides _________________ to breathe.", "label": "Yes"}
{"text": "Name: Common Darter\nScientific name: Sympetrum striolatum\nNature Stars: 30\nAbout: A small, narrow bodied dragonfly, up to 6cm long. The male is bright red, while females and immatures are golden brown. On the wing from the end of June right through to October or even November in a warm autumn. This is a very common dragonfly, breeding in all sorts of water bodies, from ponds and ditches to rivers and lakes.\nHow to identify: There are several similar red darters, which can be very difficult to tell apart.\nWhere: Found throughout the country\nFantastic fact: In the late summer, Common Darters can be found almost everywhere, sat on twigs and fences angling their wings towards the sun to warm up.\nPhotograph credit: Robbie G1", "label": "Yes"}
{"text": "From spy shots to new releases to auto show coverage, Car and Driver brings you the latest in car news.\nVacuum trucks for sale ebay\n- Hello. I had a dream of a rather fat, yellow jacket wasp, with intention to sting. It broke into my snakes cage and stung it several times. The wasp finally escaped leaving my snake in critical condition. Through out my dream, we’re doing everything we can to save it, in the end, she surivived.\n- Aug 18, 2020 · The short answer is yes, but only mildly. The venom is similar to that of a black widow spider, but nowhere near as strong and not fatal under normal circumstances. A bite will typically cause symptoms such as redness, blisters and pain around the bite. These symptoms will normally go away after a day or so.\nGiant Bee Can Kill up to 24 Humans, attacks small children Giant Bee Can Kill up to 24 Humans, attacks small children. As you may have guessed by the name, the Asian Giant Hornet is actually the largest hornet species in the world. I am curious to see if you can guess where you find these massive hornets. Wow! You are good.\n- *Minor Edit* This answer was merged at some point to include “dangerous to humans”. To put it bluntly, you'd need to be actively trying to get killed by tarantulas before you suffered any permanent damage from their venom.\nWasp Venom - Wasp venom assaults the nervous system the moment wasp venom is injected. Learn how a small dose of wasp venom can deter even the After all, why does a wasp sting hurt so much? Wasp venom is far more than just stuff that hurts; it's a multi-step micro-assault with a twofold aim\n- Dec 09, 2020 · Snake venom affects the human body in a number of ways, depending on the snake, the type of venom, and how much venom is released. Different snakes produce different types of venom, and even within a snake species, the components of venom appear to vary, depending on geographic location. This is why ...\nOnline Shopping at Gearbest for the best cell phones, electronic gadgets, toys, sporting goods, home products and apparel for geeks at unbeatable great prices.\n- For example, the ovaries of the parasitoid wasp, Asobara, undergo apoptosis if signals from their Wolbachia symbionts are lacking (Pannebakker et al. 2007). And the newborn of the squid Euprymna scolopes lacks a light organ, which is developed in cooperation between the squid and the luminescent bacteria ( Vibrio fisheri) absorbed by its ...\nShare — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. ShareAlike — If you remix, transform, or build upon ...\n- Jun 19, 2014 · The Horse’s experts answer your questions during a monthly ... and African bees that were inadvertently released in Brazil in the 1950s. ... to large amounts of bee venom are susceptible to ...\nVenom belonging to the Brazilian social wasp Polybia paulista contains the antimicrobial peptide Polybia-MP1 (MP1), which has been demonstrated to inhibit multiple forms of cancerous cells such as prostate cancer, bladder cancer and multidrug-resistant leukemic cells.\n- The definitive Internet reference source for researching urban legends, folklore, myths, rumors, and misinformation.\nJul 12, 2014 · The Type 26 frigate will be a powerful addition to the surface fleet. The remaining fleet of six destroyers, thirteen frigates, four patrol ships and seven attack submarines is sufficient to provide escort for two carrier groups plus one amphibious group and patrol the routes to the Faslane Trident SSBN base but they can only provide a limited anti-submarine capability.", "label": "Yes"}
{"text": "Mango leaves tea is a specific component of mango leaves that has medicinal properties. It has a wide spectrum of medicinal and restorative characteristics that can help with everything from minor to severe health problems. Even if you have diabetes or varicose veins, it will be beneficial to you.\nThe amazing health benefits of drinking mango leaves tea on an empty stomach first thing in the morning:-\nBlood sugar management\nMango leaves, according to WebMD, are highly effective in the treatment of diabetes. They have the capacity to boost insulin production, glucose distribution, and blood sugar control. Soak the leaves in warm water overnight. Then, to aid with diabetic symptoms, filter the water and consume it.\nControlling high blood pressure\nMango leaves have hypotensive properties and are abundant in fiber and pectin, which can help decrease bad cholesterol, manage blood pressure, and strengthen blood vessels.\nRelief from a slight fever for a short period of time\nDrinking a decoction made from mango leaves can help decrease a fever-induced elevated body temperature. Fever may be effectively treated by boiling fresh mango leaves with other plant leaves such as paw-paw, neem, cashew, bitter leaf and others.\nMango leaves; according to healthline contain antioxidants that can help fight inflammation and prevent damage produced by free radicals in the environment; which can harm cells and lead to diseases such as cancer and other ailments.\nRespiratory problems are resolved\nWhen you have a cold, bronchitis, or asthma, mango leaves are very useful. Drinking a decoction made by cooking mango leaves in water with a little honey can effectively relieve cough. It also helps in the treatment of throat tension-related voice loss.\nGet rid of stomach aches and pains\nBoiling mango leaves in the morning creates a stomach tonic that relieves stomach discomfort, promotes bowel movement, flushes toxins from the body and keeps the stomach clean.\nKeeping your weight in check\nMango leaves help the body store fat by increasing the manufacture of the hormone leptin; which is vital for fat management", "label": "Yes"}
{"text": "Ayur Vera Juice: Ayur Vera Juice is a very good detoxifier.It Cleans all the toxins from the body and very effective in constipation. It helps to cure stomach ulcers, it gives rashes free and smooth skin. It gives strength to the muscles and enhances the functions of all the endocrine organs. Ayur Vera help to prevent insomnia.\nAyuRakshak Juice: AyuRakshak Juice is the mixture of Giloy, Papaya and Wheatgrass leaves juices. It is a very good immunity booster and gives the power to fight all types of disease especially all the infectious diseases. It is helpful to produce all the particles of blood like RBC, WBC and Platelets. It is very helpful to control viral fever, influenza, Dengue Fever, Malaria, Chickengunia etc.\nLivon DS: Livon-DS is very effective liver syrup. This is the complete rejuvenator of human liver. It helps to enhance the functionality of liver. It prevents liver cirrhosis. It controls liver enlargement due to alcohol consumption. It is effective to use this product in Hepatitis.\nArshcure: Arshcure capsules herbal remedy of piles and fistula. It helps to controls bleeding and pain. Please don’t eat alcohol, ginger, meat etc. While treatment, and use it with buttermilk.\nTriphala Kadha: Triphala Kadha is a combination of three essential herbs Hard, Baheda and Amla. It is an ancient ayurvedic supplement and just like an elixir for our gut. It reduces constipation, controls indigestion, removes gas and acidity. It is also helpful to detoxify our digestion system. It improves eyesight and helps to repair hair problems\nKabzgo Churna: Kabzgo Churna is an effective combination of herbs to remove constipation by its root. It is an advanced remedy to strengthen the digestive system. It also cures making extra gases.", "label": "Yes"}
{"text": "Diet and lifestyle changes may control symptoms of crohn’s disease and lengthen the time between flare-ups.\nAn inflammatory bowel disease, crohn’s disease is marked by symptoms of abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Crohn’s disease may affect different areas of digestive tract, leading to debilitating and life-threatening complications. Crohn’s disease may be effectively treated by following certain diet and lifestyle changes.\n- Limit dairy products: By limiting and eliminating dairy products the fall-out of inflammatory bowel disease evident as diarrhea, abdominal pain and gas can be controlled effectively.\n- Having low-fat foods: If you are diagnosed for crohn’s disease, it is better to avoid low-fat foods such as butter, margarine, cream sauces and fried foods. People with crohn’s disease of small intestine may not be able to digest fat normally.\n- Limit fiber: In some people with crohn’s disease, high fiber foods may worsen the symptoms. Instead of taking raw fruits and vegetables, it is better to take them in steamed or baked form.\n- Avoid problems foods: It is always better to avoid spicy foods, alcohol and caffeine as they may worsen the symptoms of crohn’s disease.\n- Eat small meals: Those with the condition of crohn’s disease should break from the routine of tiffin, lunch and dinner. You may eat five to six small meals in a day that may help to reduce the occurrence of crohn’s disease.\n- Drink plenty of liquids: Water is the best drink for those affected by crohn’s disease. Alcohol, caffeine and carbonated drinks should be avoided as they produce gas and may aggravate diarrhea.\n- Take multivitamins and mineral supplements: Crohn’s disease inhibits the body’s ability to absorb nutrients. Taking adequate amount of multivitamin and mineral supplements ensures proper supply of nutrients to the body.\n- Overcome stress: Stress may not cause crohn’s disease, but it may aggravate its symptoms. You can manage stress effectively by practicing relaxation and breathing exercises.", "label": "Yes"}
{"text": "Typically, people breathe through their nose when they sleep. If you snore, it means you’re breathing through your mouth. It not only can affect your sleep, but it can cause partners to sleep in separate rooms. Recent evidence suggest snoring may cause thickening of the carotid arteries over time and potentially increase the risk of stroke. Snoring may be a sign of obstructive sleep apnea. Lifestyle changes, such as losing weight, avoiding alcohol close to bedtime or sleeping on your side, can help stop storing. If these changes do not help, your doctor can help identify if you have obstructive sleep apnea.", "label": "Yes"}
{"text": "A banana is the common name for a type of fruit and also the name for the herbaceous plants that grow it. These plants belong to the genus Musa.They are native to the tropical region of southeast Asia. It is thought that bananas were grown for food for the first time in Papua New Guinea. Today, they are cultivated in tropical regions around the world. Most banana plants are grown for their.\nHere you can read about 10 uses of banana plants. Uses of Banana Trees. You can eat edible sweet bananas. You can eat edible banana fruit peels. You can even eat the stem. You can use stem fibres as natural craft materials. You can use banana plant fibres to make garments. Banana leaves can be used as natural leaf platters.\nThe banana is an edible fruit, botanically a berry, produced by several kinds of large herbaceous flowering plants in the genus Musa.In some countries, bananas used for cooking may be called plantains. The fruit is variable in size, color and firmness, but is usually elongated and curved, with soft flesh rich in starch covered with a rind which may be green, yellow, red, purple, or brown when.\nEssay on banana tree in telugu language for help me write best critical thinking. 17 think critically about illustrations because illustrations always select some examples of the earth below: Large buildings smaller than xxxl. Now all she wants to do. But divesting myself of the collective imagination.\nShort essay on banana tree Ask for details; Follow Report by Sidpower3774 18.12.2017 Log in to add a comment Answers asam Ambitious; Banana is an indigenous plant of South-East Asia. It was grown in the country since ancient times. There is reference of its cultivation in the Pali literature (500-600 BC).\nHere is a list of banana tree uses. According to Ayurveda, all the parts of the Banana tree have healing properties. The banana tree uses are listed as follows: juice of banana flowers helps during painful menstruation, juice of banana stem helps in flushing out kidney stones, banana leaves alleviate stomach disorders, banana corm reduces acidity and burning sensation.\nFind an answer to your question 5 lines essay on banana Banana is a fruit which is yellow .This plant belong to the Guinness Moosa they are native to the tropical region of south east asia there are about 110 different spices of Banana it is thought that banana we are grown for food for the first time in Papua New Guinea today they are cultivated in tropical regions around the world most.\nJames began to publish short stories and writing plays. In 1976 he published Bluefoot Traveller, a book of black British poetry. Since his early days in this country, James has remained an active campaigner on the part of black people and has helped to promote young black writers in particular.\nAdopting a brand extension strategy to bring the two under the umbrella “Banyan Tree” brand could have had a positive halo effect on the perceived quality of Angsana Spa and Colours of Angsana on one hand but on the other, it could have led to “Banyan Tree” brand dilution and dented the customer perceived value because the customers no longer would be able to identify with BTHL as a.\nBanana trees are one of the common trees that come to mind when dreaming of the tropics, but did you know that it is not really a tree? It is actually the world's largest herb. On banana plantations in the tropic the plants must be pruned to the ground after fruiting. The trunk is composed of the main fruiting stem enrobed by leaves.\nEssay on trees are able to be used in sanskrit tree in sanskrit, sanskrit. Essay banana tree in sanskrit get help with your writing 1 through 30. 10 lines on banana tree in sanskrit language in the banana tree. Jpg. Free essays on the air and doing your writing 1 through 30. Title: the back of a banana tree, sanskrit, the tree in sanskrit search.\nEssay text: That same large banana even has 2 grams of protein and 4 grams of fiber. No wonder the banana was considered an important food to boost the health of malnourished children, those reducing sodium in their diets cannot go wrong with a banana with its mere 2 mgs of sodium.\nBanana tree essay.. .. Write a narrative essay on a lost key. Menu. Banana tree essay.\nThis is what was so special to him. Moral Genre of the story. The Banana Tree The genre of this story is, an exciting story in as much as it keeps you on your toes, because you don't know what will happen to the boy. It is also quite a sad story because you do feel for the.\nBanana plant is not a tree,it is the largest herb in the world. It can grow upto 20 to 25 feet high. The functional trunk formed by upright concentric sheathing base of long broad leafs. It is a perennial herb. Bananas propagate through rootstalk rhizome. Banana flower is large, long, oval, tapering and purple color.It looks like a large bud.Translation for 'banana' in the free English-Hindi dictionary and many other Hindi translations.Bananas grow on plants called banana palms.While many people think that banana palms are trees, they are actually considered to be an herb. In fact, the banana palm is the largest herb in the world.", "label": "Yes"}
{"text": "The rising global demand for animal products and the growing public concerns about the environment and animal welfare require dairy farms to improve their efficiency and apply more sustainable farming systems. Precision Livestock Farming (PLF) could represent a valuable support in addressing these challenges. In recent years, dairy farms have been modernising and introducing new sensors and automatic systems for managing the herd. However, the diffusion of new technologies in Italian dairy farms is still limited and farmers are reluctant to invest in precision systems. The aim of the study was to investigate the presence of PLF tools in Italian dairy farms, the motivations, benefits and limits of technological investments from the farmers' point of view and the factors affecting the diffusion of technology. From November 2020 to June 2021, an online questionnaire was distributed and 52 responses were obtained. About 79% of the farms were located in Lombardy. The...\nDiffusion of precision livestock farming technologies in dairy cattle farms.\nA. Sandrucci, Department of Agricultural and Environmental Sciences, University of Milan, 20122 Milan, Italy. E-mail firstname.lastname@example.org\nBianchi, M. C., Bava, L., Sandrucci, A., Tangorra, F. M., Tamburini, A., Gislon, G., Zucali, M.; Diffusion of precision livestock farming technologies in dairy cattle farms.. IFIS Food and Health Sciences Database 2023; doi:\nDownload citation file:", "label": "Yes"}
{"text": "by Republic of Kenya, National Council for Science and Technology in [Nairobi] .\nWritten in English\n|Series||NCST ;, no. 40, NCST (Series) ;, no. 40.|\n|Contributions||National Council for Science and Technology (Kenya)|\n|LC Classifications||SB295.Q38 M35 1996|\n|The Physical Object|\n|Pagination||ii, 52 p. :|\n|Number of Pages||52|\n|LC Control Number||99890362|\nCatha edulis (khat) is a plant grown commonly in the horn of Africa. The leaves of khat are chewed by the people for its stimulant action. Its young buds and tender leaves are chewed to attain a state of euphoria and stimulation. Khat is an evergreen shrub, which is cultivated as a bush or small tree. The leaves have an aromatic odor. Alsalahi A, Alshawsh MA, Mohamed R, et al. Conflicting reports on the role of the glycemic effect of Catha edulis (Khat): A systematic review and meta-analysis. J Ethnopharmacol. ; Khat is a stimulant made up of fresh leaves of the Catha edulis shrub found in East Africa and southern Arabia. It contains a variety of chemicals. Abstract. The khat plant (Catha edulis) is produced in certain areas of East Africa and the Arabian peninsula, and the leaves are chewed for their stimulating effect. Fresh material, which is preferred by users, contains a substance that is rapidly converted to (+)-norpseudoephedrine. As a consequence of the traditional means of consumption, intoxication with khat is self-limiting but chronic.\nCatha edulis Forsk., its preparations, derivatives, alkaloids and salts, including: (1) Cathine (d–threo–2–amino–1–hydroxy–1–phenylpropane). Flanman31 , 16 September (UTC) While there are numerous spellings, and all of them are acceptable, there is always a preferred spelling. Catha Edulis is a psychoactive plant found in East Africa and Western Arabia. Depending on who you ask, Khat may be considered a deadly drug or a cultural tradition. This book goes into detail on the psychoactive effects whether Instantaneous, Long Term Usage, or : $ Jeffrey K. Aronson, in Manson's Tropical Infectious Diseases (Twenty-third Edition), Khat. Khat or qat (cafta, miraa, muiragi) is a stimulant commonly used in East Africa, Yemen, and southern Saudi Arabia and is derived from a small tree, Catha edulis. The leaves and twigs are chewed while fresh, but can also be smoked, infused in tea, or sprinkled on food. Catha edulis (khat, qat frae Arabic: القات ) is a flouerin plant native tae the Horn o Africae an the Arabian commonties frae these areas, khat chowin has a history as a social custom datin back thoosands o years. References.\nCatha edulis will grow well in full sun or part shade. It’s ideal is 80 degrees (f) at about the ′ elevation in the tropics. This translates well to part shade, 80 degrees (f) at lower elevations. Generally, the more red on the stems and veins of the leaves, the stronger the Khat is considered to be. Khat (catha edulis) is a psychoactive shrub whose tender leaves and twigs are chewed in the Horn of Africa and the Arabian Peninsula for their euphonizing effects for a millennium. A stimulant grown in small gardens for consumption on cultural and religious occasions around the turn of the last century, khat has now become the preferred and Author: Ezekiel Gebissa. Simon Gibbons, Warunya Arunotayanun, in Novel Psychoactive Substances, Catha edulis (Khat). Khat (Catha edulis Forsk. ex Endl.) is a small tree from the Celastraceae plant family that grows in East Africa and the Southern Arabian crude drug material has a number of names in various locations such as ‘qat’ (Yemen), ‘tchat’ (Ethiopia), ‘qaad or jaad’ (Somalia) or. Catha forskalii . Catha inermis . Celastrus edulis Vahl. Dillonia abyssinica Sacleux.. Methyscophyllum glaucum Eckl. & Zeyh. Trigonotheca serrata Hochst.", "label": "Yes"}
{"text": "Your liver is an amazing organ that can regenerate very quickly given the proper rest, lifestyle habits, and nutrition. If it becomes tired, sick, or injured you will notice specific symptom patterns and body changes that get worse over time. Use this article to educate yourself and your family on liver function.\nLearn about the symptom pattern and body type of the ovaries. The life-giving ovaries produce hormones that are important to the emotional and physical wellbeing of women of any age. Use the information to understand if your symptoms are directly tied to your ovaries and what to do about it.\nThe thyroid, located in the middle of the neck sends signals (hormones) to the liver that in turn regulates our energy production. Learn how the thyroid impacts metabolism and how this is experienced through symptom patterns and body composition changes.\nThe pituitary gland is only the size of a pea, yet it regulates our entire hormonal system. This gland is very sensitive as can be malnourished or overstimulated causing loads of problems into adulthood including extreme under and overdevelopment, infertility problems, and tumor susceptibility.\nThe gonads are a combination of glands that include the testes, prostate, and cowper's. These glands work together to produce hormones and function to the male reproductive system. If not properly nourished and rested, these glands cannot produce enough hormones and thus unfavorable physical results.\nThe adrenal glands do so much considering they are about the size of a walnut. They help balance blood sugar, they help make energy, and they even help make a fertility hormone. Learn about the symptoms and body composition patterns of these remarkable glands.\nYou can benefit from learning how to balance your hormones naturally. Use the information and quiz in this article to reduce food cravings, lose weight-gain in specific areas, and reduce common symptoms.", "label": "Yes"}
{"text": "You wouldn’t apply a tourniquet to a bruise. Or put an ice pack on an ulcer. Those would be the wrong treatment protocols for those particular conditions.\nYet, when it comes to care for chronically infected gums and loss of bone—the markers of periodontitis—dental professionals are trained to provide acute wound treatment protocols.\nIt may not seem like a huge difference. But let’s consider the fundamental differences between treating acute wounds and treating chronic wounds. And let’s take the tourniquet off the bruise.\nTraditionally, gum disease (periodontitis) has been addressed the same way you might approach a broken bone. Namely, it has been treated as a trauma with acute care, including scaling, root planing and even surgery.\nAnd it’s hard to argue with this “head-on” approach to addressing this troubling issue.\nGum disease is a disruptive and destructive problem, and no one wants to withstand it any longer than absolutely necessary. Oddly enough, an acute response alone can actually prolong the disease if it is not matched with chronic wound care.\nStudies indicate that scaling and root planing, the most common treatments of periodontitis that physically remove bacterial colonies called biofilms, leave behind the bacteria that caused the infection in the first place. And worse yet, the pathogens repopulate because it is impossible for the instruments to remove all of the biofilm.\nSo, what’s the answer?\nIf you ask the American Medical Association (AMA), chronic wound management is it. And gum disease, specifically periodontitis, fits the chronic wound model.\nNow the questions become, “how is chronic care different, and how do you deliver it to the gums?”\nChronic care protocols address the infectious agents first. Then, they debride the wound and encourage it to heal from within. In order to do that for the gums, we prescribe a customized sealed Perio Tray to deliver a low concentration of hydrogen peroxide gel deep below to gums to establish an oxygen rich environment that simultaneously debrides pathogens, and encourages wound healing.\nThe Perio Tray® does more than lock in the treatment. It compresses the wound and increases the oxygen levels below the gums. With the sealed tray, the hydrogen peroxide release of oxygen takes place at the site of the infection. Peroxide performs as an oral debriding agent and oral wound cleanser. The Perio Tray is important because it delivers the medication deep below the gums where these chronic oral wounds hide from toothbrushes, rinse and floss.\nIf this all seems revolutionary, it’s not.\nThe Perio Protect Method, combining acute and chronic care, simply follows the AMA guidelines for treating chronic wounds, and the results speak for themselves.\nResearch and case studies have shown treatment of chronic periodontal disease with a direct medication delivery method significantly decreases bleeding upon probing and shrinks the depth of periodontal pockets1.\nBy creating the right environment for treatment, this approach compresses the wound and addresses the bacterial cause, allowing the wound to heal from the tissue level. The treatment suppresses damaging bacteria and encourages healthy bacteria for healthy gums.\nWhere acute care addresses the immediate needs, chronic care—like daily Perio Tray delivery—addresses the cause.\n1 Cochrane RB and Sindelar B. Case Series Report of 66 Refractory Maintenance Patients Evaluating the Effectiveness of Topical Oxidizing Agents. The Journal of Clinical Dentistry 2015;26:109-114. Putt M, Mallatt M, Messmann L, and Proskin H. A 6-month clinical investigation of custom tray application of peroxide gel with or without doxycycline as adjuncts to scaling and root planning for treatment of periodontitis. American Journal of Dentistry. 2014;27:273-284. Putt M and Proskin H. Custom Tray Application of Peroxide Gel as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis: Results of a Randomized, Controlled Trial after 6 Months. The Journal of Clinical Dentistry. 2013;24:100-107.", "label": "Yes"}
{"text": "My research focuses on the behaviour and wellbeing of companion animals, and their interactions with humans. I am particularly interested in play behaviour as shown below, and in developing ways ...\nNicola graduated from Leicester University (Hons, 1st class), before completing a PGCE. After studying mink anatomy and diet, (WildCRU, Oxford University), she moved to Southampton University to complete a ...\nResearch: Animal Welfare and Behaviour\nView complete publications list in the University of Bristol publications system\nEdit this profile If you are Dr Nicola Rooney, you can edit this page. Login required.\nAll details on one page > for printing etc.", "label": "Yes"}
{"text": "Statewide Wild Turkey Studies Underway – Laker Country 104.9 FM WJRS\nTwo ongoing research projects should shed light on why Kentucky’s turkey crop has fallen since its 2010 record.\nHunters reported harvesting 26,836 turkeys during the state’s 2022 spring seasons. While this level is comparable to the peak of the turkey population boom in the early 2000s, it is well below Kentucky’s record spring harvest of more than 36,000 turkeys 12 years ago, and the average of the last 10 years of 30,822 harvested.\nKentucky is not alone in suffering a decline in its turkey crop.\n“This is a range-wide phenomenon – it’s happening in other states as well,” said Zak Danks, turkey program coordinator for the Department of Fish and Wildlife Resources of the United States. Kentucky. “Researchers are talking and collaborating with each other, trying to figure out what’s going on in the wild turkey’s range.”\nKentucky is currently working with Tennessee Tech University and the University of Georgia on a turkey breeding study. Researchers are studying the nesting success and survival rates of young birds. Biologists will study how predators, weather, habitat and gobage affect the number of turkeys that reach adulthood.\nAnother ongoing study examines the impact of hunting on the herd. For this research, conducted in partnership with the Tennessee Wildlife Resources Agency, biologists began banding male turkeys earlier this year. Researchers will continue to band birds until 2025 to better understand the number of birds captured by hunters compared to the number of birds that die from other causes, such as predators.\nBen Robinson, acting director of the department’s Wildlife Division, warned that researchers need to complete the entire project before beginning to interpret the results.\n“Drawing conclusions now would be like calling the Kentucky Derby halfway through the race,” he said.\nSeveral factors impacted the turkey season this spring, including spells of cold and wet weather. The holidays may also have affected the number of hunters: Easter fell during the opening weekend while the spring season ended on Mother’s Day. Other factors during the spring season, such as the Kentucky Derby, youth sports or other group activities, once again competed for people’s time.\nLicense sales figures this year indicate that the uptick in hunting and fishing participation during the pandemic has declined as COVID restrictions have eased.\nSales of licenses and permits authorizing the hunting of turkeys fell 6.6% in 2022 compared to the previous year. Still, an estimated 75,000 to 85,000 people hunted in Kentucky during the spring 2022 turkey season.\nIn preliminary results of a currently ongoing survey of 2,022 turkey hunters, a significant percentage reported that they stopped hunting after harvesting a turkey due to concerns about declining turkey numbers. Final results will be available upon completion of the survey later this month. This factor and other factors related to participation may explain the drop in the 2022 harvest.\nLess gobbling observed by turkey hunters this spring – as indicated in the current post-season survey – is likely correlated with below average poult recruitment in 2020, reflected in the results of the annual brood survey statewide summer. However, last year’s brood survey indicates above average recruitment of young turkeys.\n“We’ve heard from many hunters who have seen more jakes this spring, raising expectations for a good crop of 2-year-old gobblers to hunt next year,” Danks said.\nAs researchers and wildlife managers seek to better understand what might be happening with turkeys in their range, the Kentucky Fish and Wildlife Commission offered several recommended changes at its meeting last December to combat proactive against perceived decline.\nThe committee recommended:\nA bag limit of one turkey per hunter per Wildlife Management Zone per season.\nEliminate the harvest of beardless turkeys during fall hunting seasons.\nExtend wildlife baiting ban from May 31 to July 31. Bait piles promote artificially high concentrations of predators and turkeys at bait sites, likely increasing predation and health risks to turkeys.\nExtend the night coyote hunting season with rifles until June 30, except that the season would be closed from April 1 to May 15. Hunters on private land could use any legal modern firearm, centerfire and rimfire.\nThe recommended changes to the regulations are not yet in effect, as they must receive legislative approval before becoming law. Before leaving, hunters should always consult the hunting guide in force, published by the department to summarize the regulations in force. Hunting guide booklets are available at fw.ky.gov and from licensing agents.\nDanks said crop fluctuations could be part of the normal cycles of a turkey population that has already peaked. In 1978, Kentucky’s turkey population was estimated at only 2,000 turkeys. It took almost two decades before the flock exceeded 100,000 birds. Flock estimates have stabilized at around 200,000 to 250,000 since 2002, indicating that Kentucky could have as many turkeys as the landscape will support.\n“When populations increase, they generally have a higher reproductive rate,” Danks said. “When a population reaches the carrying capacity of the environment, it exceeds that capacity for a short time and then declines, followed by fluctuations.”\nThe 2010 season is an example of overflow. A large outbreak of 17-year-old cicadas in 2008 provided poults with a substantial food source that also distracted predators from their focus on turkeys and other prey. Survival rates skyrocketed, leading to the record harvest two years later.\nThis is why studies will focus on the survival of turkeys. Have all the best nesting sites and habitats been captured due to the number of birds in the flock?\n“There is only a limited amount of habitat available for turkeys,” Robinson said. “Once we hit the carrying capacity of the turkey flock, we start to see fluctuations.”\nHunters and other wildlife enthusiasts can help monitor the wild turkey population by submitting sightings of turkeys in July and August each year. Visit fw.ky.gov and search the keywords “turkey survey” and select the preferred method for completing the summer brood survey.", "label": "Yes"}
{"text": "View principal investigators in microbiology and infectious diseases. If you're looking for a topic to write a microbiology research paper on, feel free to use the article that will help you craft your own original subject. Microbiology essays: over 180,000 microbiology essays, microbiology term papers, microbiology research paper, book reports 184 990 essays, term and research papers. Your sample microbiology term paper online free example of a term paper on microbiology topics and ideas for college and university students tips how to write good. Buy custom biology essay, biology term paper, biology research paper, biology thesis or biology dissertation of high quality writing biology papers with us is the.\nMicrobiology publishes topical, high-quality reviews and research papers on all aspects of the field. Toward more transparent and reproducible omics studies through a common metadata checklist and data publications by robert grossman, kolker e, Özdemir v, martens l. Queer theory in qualitative paper microbiology research research architectural science review,, and ahrentzen, s architectural research quarterly. Microbiology research is an international, online-only, open access peer-reviewed journal which publishes original research, review articles, editorials, perspectives.\nFood borne incident relating to escherichia coli efficient and effective supervision of contamination of food and inspection of food borne diseases in uk needs. As a writing company, privatewritingcom also specializes in writing biology research papers. Melissa babajko microbiology 214ba dr may june 6, 2012 staphylococcus aureus- is a facultative anaerobic, gram-positive, salt positive, cocci shaped.\nThe impact factor measures the average number of citations received in a particular year by papers published in research in microbiology is the direct. Food microbiology information website providing academic research services to the food industry relating to food hygiene, food poisoning, spoilage and related issues.\nMicrobiology research project introduction you are going to have an opportunity this semester to have some fun with science by designing and carrying out your own. The student is responsible for assignments (such as designated papers from the scientific literature) text: beishir microbiology in practice ed6. 1 scientific writing for microbiology majors the main purpose of most scientific writing is to inform and educate other people about research that has been performed. Dissertation help ireland nottingham microbiology research paper dissertation histoire du droit methodologie homework help for circumference.\nA guide to writing research papers for introductory microbiology (bisc 137 and bisc 137w) david morris, department of biological sciences a research paper is a report. Microbiology journal archives of microbiology publishes papers on all areas of basic research in microbiology.", "label": "Yes"}
{"text": "DNA ligase makes recombinant DNA technology possible.\nIn this lesson, you will learn how new versions of genes can be designed for experiments in novel host organisms using DNA ligase.\nThe goal of genetic engineering is changing the genetic makeup of an organism. Recall that we previously learned that a restriction enzyme is an enzyme that can cut DNA and that these enzymes are commonly used in genetic engineering experiments. Scientists can use restriction enzymes to excise a specific gene from a genome and add it to a DNA plasmid to create a completely new recombinant version of the gene.But, restriction enzymes just provide half of the story, right? To actually create recombinant DNA, pieces of DNA must be pasted together. That’s where the enzyme DNA ligase comes in.\nReview of DNA Ligase in Replication\nIf you recall, nature encountered a similar challenge to the one we’re facing as scientists.\nDuring DNA replication, a cell makes an exact copy of each DNA molecule. However, because DNA polymerase (the enzyme that builds new DNA molecules) can only function in one direction with respect to DNA, a cell must treat each side of the replication fork slightly differently. At the leading strand, DNA polymerase can add nucleotides to build the new DNA molecule without stopping.In contrast, as the replication fork opens, discontinuous fragments of DNA are built at the lagging strand. These fragments are then glued, or ligated together, by DNA ligase.\nMechanism of DNA Ligase\nNow, you may wonder why DNA ligase is even necessary. I mean, the hydrogen bonds are holding the two molecules together. That should be good enough, right? Recall, though, that hydrogen bonds are constantly broken and reformed during such cellular processes as replication and transcription.Consider the structure of a DNA nucleotide. A nucleotide consists of a nitrogenous base, a sugar, and a phosphate.\nSo far, we’ve been considering the hydrogen bonds that hold the complementary bases together in a DNA molecule. Now let’s consider the bonds that hold each DNA backbone together.Recall that the backbone of each DNA strand is composed of the sugars and phosphates of the individual nucleotides linked by a covalent bond called a phosphodiester bond. To generate the DNA fragments, the restriction enzymes broke the phosphodiester bond holding the sugar and phosphate together. Because a covalent bond is a high-energy bond, an enzyme is required to make forming the bond energetically possible. DNA ligase serves this role.\nIn our experiment, it will glue the human insulin gene into a bacterial DNA plasmid, thus forming a recombinant DNA molecule that will soon be able to produce human insulin. Note that we have only considered a specific genetic engineering experiment that utilizes restriction enzymes that generate sticky ends. However, while not all forms of genetic engineering require these specific enzymes, virtually all recombinant DNA experiments require the use of DNA ligase to create a recombinant plasmid for storage or amplification.\nRestriction enzymes are enzymes that can cut DNA.\nYou can think of restriction enzymes as molecular scissors. DNA ligase is an enzyme that can join two DNA molecules. You can think of DNA ligase as molecular glue. DNA ligase joins two DNA molecules together by forming a phosphodiester bond between the two molecules.\nAt the end of this lesson, you’ll be able to define restriction enzymes and DNA ligase and explain their functions in engineering recombinant DNA.", "label": "Yes"}
{"text": "Researchers have discovered that a naturally-occurring compound found in trees is effective in combating superbugs.\nDrug-resistant bacteria occur in more than 2.8 million infections and are responsible for 35,000 deaths per year with common antibiotic-resistant “superbugs” causing diseases such as sepsis, urinary tract infections and pneumonia.\nNow scientists at the University of Portsmouth, in a study published in the Tropical Medicine and Infectious Diseases journal, have found the compound hydroquinine, which can be used to treat malaria in humans, has bacterial killing activity against several microorganisms.\nA university spokesman said: “Antimicrobial resistance has become one of the greatest threats to public health globally.\n“It occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines, making it difficult to treat infections. Because of this, there is a pressing need for the development of new antimicrobial drugs to combat infections.”\nWorking with colleagues at Naresuan and Pibulsongkram Rajabhat Universities in Thailand, the team found that hydroquinine was effective against the pathogen pseudomonas aeruginosa which is associated with high mortality rates of between 30% and 50%.\nDr Robert Baldock, of Portsmouth’s School of Pharmacy and Biomedical Sciences, said: “Using bacterial-killing experiments, we found that hydroquinine was able to kill several microorganisms including the common multidrug-resistant pathogen pseudomonas aeruginosa.\n“By studying this compound further, our hope is that it may in future offer another line of treatment in combating bacterial infections.”\nDr Jirapas Jongjitwimol, from the Department of Medical Technology at Naresuan University, said: “Our future research aims to uncover the molecular target of hydroquinine.\n“This would help our understanding of how the compound works against pathogenic bacteria and how it could potentially be used in a clinical setting.”\nLeave a Comment\nYou must be logged in to post a comment.", "label": "Yes"}
{"text": "Reduced BrdU labeling in R6/2 mice, but no reversal by asialoEPO. All mice were injected with 50 mg/kg of BrdU i.p. every 12 h for their last six days of survival in order to assess whether asialoEPO would affect cell proliferation in the R6/2 mice at the age of 12 weeks. The number of BrdU labeled cells was assessed by stereology in the subventricular zone in five striatal sections/mouse. In this region, there was only a trend towards a reduced number of BrdU labeled cells in R6/2 mice compared to their wild-type littermates (A; one factor ANOVA, F (2, 16) = 1.63, n.s.). In the dentate gyrus, BrdU labeled cells were assessed in 7–9 sections/mouse from the first anterior aspect of the structure, and the number was expressed as the average number per section (B). The data were analyzed using a one factor ANOVA (F (2, 16) = 23.50, p < 0.0001) that revealed a significant difference between the groups. In this region, we found that there was a reduced number of BrdU labeled cells in R6/2 mice compared to wild-type mice (Bonferroni-Dunn post-hoc test, p < 0.0001). However, the administration of asialoEPO was not able to reverse the reduced cell proliferation (Bonferroni-Dunn post-hoc test, p > 0.05).", "label": "Yes"}
{"text": "HIV contaminated people can go through an enormous choice of lab tests, a portion of these tests might incorporate viral burden test and CD4 test. However antiretroviral treatment can be managed to people determined to have HIV, it is inordinately difficult to foresee the “ideal opportunity” to start treatment since conclusion of this viral contamination can be extremely challenging as it is especially like common viral diseases and can likewise be asymptomatic.\nThe viral burden test or Los Angeles std the antiretroviral [ARV] treatment is the main treatment accessible that has promising outcomes to patients who has been contaminated by the HIV. However reports and criticism from individuals who have gone through the treatment has affirmed the treatment’s wellbeing and unlikelihood of causing complexities, still there are things that are not to be underestimated, for example, potential inconveniences in the medication treatment like for example; unfavorable impacts, obstruction, adherence, and associations. The sort of use of the treatment is as yet bantered on when it is ideal and most adequately applied, yet the treatment on the development phase of HIV is most accepted by the greater part to be best and effective chance to control treatment.\nThere are simply a modest bunch tests accessible to determine a grown-up to have HIV, among all, the most utilized and reasonable test for grown-ups would be the HIV Antibody test. ELISA (protein connected immunoabsorbent) or EIA (catalyst immunoassay) is the most utilized neutralizer test since it is known for its accuracy and is modest. The location of the HIV can be made as ahead of schedule as 6-12 weeks. The antibodies of the contaminated individual will battle of the disease, and in this way by utilizing the counter acting agent test, it will presently check the spit, pee, or blood for antibodies. Assuming that Hive antibodies are found in any of the three, you would now be able to announce a HIV disease.\nHIV testing is basically encouraged to be taken by individuals who participate in unprotected sex, individuals who shared infusions of medications, or apparently presume that they were managed with a pre-owned needle, and to individuals who are or alternately were uncovered by HIV in their work environment. In any case, the test is available to each person who wishes to take it, as long as you presume that you may be tainted with HIV, you can step through the exam\nHIV testing should be possible in your home by home testing units by getting a blood test of yourself and sending it to a research facility for HIV testing. However many would favor the home unit for reasons of saving themselves from the modesty of entering a STD facility and forestalling an outrageous passionate breakdown out in the open, you should recall that the accuracy of the blood inspecting is in danger when you do it without anyone else’s help, it is generally encouraged to have the test in a STD center, where you can have a full sweep and full test and the doctor can have a full history and advancement of your condition.", "label": "Yes"}
{"text": "How Cannabinoids Heal & The Endocannabinoid System\nIn recent years, we have learned that the medicinal powers that cannabis holds are vast. In order to understand the health benefits of cannabinoids and cannabis, we need to first get familiar with the endocannabinoid system.\nThe endocannabinoid system (ECS) is a biochemical communication system in the human body, largely comprised of endocannabinoids, receptors, and enzymes that regulates various functions including sleep, mood, memory, appetite, reproduction, and pain sensation. This intricate system was first discovered in the 60's and 70’s when scientists were researching the effects of cannabis on the human body. The ECS allows our bodies to process and interact with cannabis and its phytocannabinoids which is why we feel benefits like pain relief and anxiety reduction when we consume it.\nWe can gain a deeper understanding of the system by defining the word endocannabinoid, which simply means ‘cannabis-like substances that naturally occur inside us’. The key function of the ECS is returning us to or maintaining homeostasis. Homeostasis is your body's internal balance system that works to keep everything in the right ‘zone’. Think of homeostasis as the control panel for your internal environment - things like your heartbeat, temperature, hunger gauge, and immune response are all regulated by homeostasis. When something goes haywire within the body, your ECS acts as a rescue team to correct it.\nSo how does the ECS know when to act? Extensive research points to two cannabinoid receptors found in select tissue on the surface of cells:\nCB1 - which is in the central nervous system (brain and nerves of the spinal cord, this receptor also triggers psychoactive effects)\nCB2 - which is in the peripheral nervous system (nerves in your extremities), the digestive system, and specialized cells within the immune system. Work to moderate inflammation and immune response.\nCB1 and CB2 aren’t the only receptors but they are the most studied receptors.\nThese receptors ‘sit’ on cells within various systems throughout our body and allow communication and coordination between different cell types. Streamlined communication between cells allows our body to respond to needs like injuries or illness by deploying help from multiple internal systems. The endocannabinoid system, with its complex actions in our immune system, nervous system, and all of the body’s organs, is a literal bridge between body and mind.\nEndocannabinoids - What Are They?\nEndocannabinoids (eCBs) are naturally produced molecules within the body that bind to and activate cannabinoid receptors. Much like neurotransmitters, eCBs are chemical messengers for the ECS. These molecules are made only when they are needed and are crucial to maintaining communication between cells. Plant cannabinoids like THC can also activate receptors but each produces a different response based on the receptor it interacts with. Noting that over 100 different cannabinoids have been identified within the cannabis plant, there are endless responses and benefits that each compound could trigger within the body.\nEnzymes In The ECS\nThe last of three key components of the endocannabinoid system, enzymes! Also molecules, metabolic enzymes ensure that endocannabinoids get used up and then quickly destroyed. ECS enzymes work to immediately break down cannabinoids after use, rather than storing them like many other systems in the body. It’s worth mentioning that these enzymes have a particularly difficult time breaking down THC, which is why it can linger in our cells for months after use.\nCannabinoids & How They Heal\nNow that we have a greater understanding of the ECS that exists within us, it becomes much more clear as to how we as humans are biologically built to reap the benefits of cannabis.\nAn excellent example can be found in CBD. CBD is unique in that it doesn’t directly trigger or attach to either major receptor. Instead, it modifies the receptor’s ability to bind to cannabinoids which increases your levels of natural endocannabinoids by occupying specific enzymes. This receptor modification is thought to make other phytocannabinoids more impactful when ingested with CBD. The benefit of CBD doesn’t stop at cannabinoids, CBD also interacts with non-cannabinoid receptors within the body like the 5ht serotonin receptor (treating various mental disorders) and the TRPV1 receptor, which is responsible for pain and inflammation.\nCBN is another cannabinoid that interacts with both CB1 and CB2 but doesn’t ever bind to either receptor. Instead, CBN prefers to influence CB2 which provokes TRPV2 receptors responsible for promoting therapeutic feelings. CBN is a highly regarded sleep aid known for increasing mood-enhancing chemicals. CBN is a key component in our Good Night formula.\nAn additional mood-boosting cannabinoid is CBDA. It provides therapeutic effects throughout our body by activating 5-HT1A, which are serotonin receptors. CBDA is special due to having a much stronger binding affinity than CBD as an antagonist at an important receptor known as GPR55. Other medicinal benefits that CBDA is known for: anti-nausea, treatment for epilepsy (reduction of seizures), and high anti-inflammatory properties.\nBy diving into the ECS and how it works, we uncover a lesser-known look at the direct impact that each cannabinoid has on our body. Whether you’re new to cannabis or are a regular user, having this knowledge about the health benefits of cannabinoids means we are better equipped to single-out cannabinoids that can treat needs specific to our individual health and wellbeing.\nFurther research on the ECS can be found by visiting our sources below!\nZlebnik Natalie, Cheer Joseph. Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?\nSulak, Dustin. DO. Introduction to the endocannabinoid system.", "label": "Yes"}
{"text": "top of page\nOrganic Liquid Compost\nOur organic liquid compost potion is used to encourage flowering and fruiting; to feed plants as it enter the fruiting stage.\nHow to use\nReady to use\nAt the sign of first budding / flowers: spray liberally on both sides of leaves or use as a soil drench.\nContinue throughout life of plant, use once every 2 weeks.\nCaution: A little bit goes a long way! Follow directions to avoid overdosing!", "label": "Yes"}
{"text": "Welcome to Humberto Jorge, the new protein analyst at Alphalyse.\nHere are a few things you should know about Humberto:\n👉His expertise includes peptide quantification using the isobaric mass tag, phosphorylation enrichment, and several chromatography methods.\n👉Humberto holds a PhD in Biochemistry from the Leibniz Institute for Analytical Sciences (ISAS) in Dortmund, Germany.\n👉He comes from a position as Research and Development Analyst at Blau Farmacêutica in Sao Paolo, Brazil.\n👉As a native-born Brazilian, Humberto speaks fluent Portuguese and English.\nAt Alphalyse, Humberto will use his 10+ years of protein analysis experience from the academic world and the industry to run advanced characterization projects.", "label": "Yes"}
{"text": "A recent article about Myriad Genetics makes some important points (see; Despite Gene Patent Victory, Myriad Genetics Faces Challenges). Here's an excerpt from it:\nMyriad Genetics retained its monopoly on a lucrative genetic test for breast cancer risk when a federal appeals court recently upheld the company’s patents on two human genes — and the validity of gene patents in general. But newer DNA-sequencing techniques are far faster and only a fraction of the cost of the 1990s technology that Myriad uses. Indeed, it will soon be possible to sequence a person’s entire genome, all 22,000 or so genes, for less than Myriad charges for just two genes. Executives at Myriad say they are preparing for changes. Although its major patents start expiring in 2014, the executives say the company’s patent protection should last until at least 2018. They say that will give the company time to adopt new technology and to diversify beyond the breast cancer test, which accounted for $353 million, or 88 percent, of Myriad’s $402 million in revenue in the fiscal year that ended in June. The company also plans to rely less on patents and more on trade secrets. Because it has done so much more testing than anyone else, Myriad has more information on which of the thousands of possible mutations in the two genes actually raise the risk of getting cancer. Myriad used to share such information with a public database maintained by the National Institutes of Health, and it cooperated with academic scientists trying to analyze the mutations. But a few years ago, the company quietly stopped contributing and cooperating, in favor of building its own database....Myriad executives have said that when [another] laboratory finds a mutation in either of the two genes, 20 to 40 percent of the time it does not know if the mutation raises the cancer risk. They say that Myriad’s rate of uncertain findings is just 3 percent.\nMyriad was one of the first, and certainly one of the most successful commercial laboratories, to offer molecular diagnostic testing. Their most important test, BRACAnalysis, revealed the predisposition of some women to hereditary breast and ovarian cancer. The genes being tested are BRCA1 and BRCA2. Although this article starts off by referring to recent advances in automated genotyping and patents, it quickly gets to the point. Myriad's strategic advantage lies not in its technology that has been perfected over many years but rather in its trade secrets. These consist of the company's acquired knowledge of exactly which mutations within the BRCA1 and BRCA2 genes are significant, There can be numerous DNA errors at these two loci but not all of them are clinically significant. Myriad, based on experience and its proprietary database, has a better idea which ones to worry about than anyone else.\nThere is no question that Myriad has a major, and well-earned, advantage with its proprietary database. However, I am not as certain as the company about how long this advantage will last. BRCA1 and BRCA2 mutations are of great interest to academic oncology researchers because they code for cancer in two organs. These researchers will strive to make sense of the underlying genetic mechanism regardless of any transient patent victory that Myriad has achieved. They also have modern genotyping tools and knowledge at their disposal. In other words, Myriad has bought some time and its reliance on trade secrets will protect its revenue stream for a short time. I am betting, however, that this company advantage will not last much longer and certainly not until 2018.", "label": "Yes"}
{"text": "Molecular Control by Non-coding RNAs During Fruit Development: From Gynoecium Patterning to Fruit Ripening\n- Laboratory of Molecular Genetics of Plant Development, Department of Biological Sciences (LCB), Escola Superior de Agricultura “Luiz de Queiroz” (ESALQ), University of São Paulo, São Paulo, Brazil\nFruits are originated from the transition of a quiescent ovary to a fast-growing young fruit. The evolution of reproductive structures such as ovary and fruit has made seed dispersal easier, which is a key process for reproductive success in flowering plants. The complete fruit development and ripening are characterized by a remarkable phenotypic plasticity which is orchestrated by a myriad of genetic factors. In this context, transcriptional regulation by non-coding small (i.e., microRNAs) and long (lncRNAs) RNAs underlies important mechanisms controlling reproductive organ development. These mechanisms may act together and interact with other pathways (i.e., phytohormones) to regulate cell fate and coordinate reproductive organ development. Functional genomics has shown that non-coding RNAs regulate a diversity of developmental reproductive stages, from carpel formation and ovary development to the softening of the ripe/ripened fruit. This layer of transcriptional control has been associated with ovule, seed, and fruit development as well as fruit ripening, which are crucial developmental processes in breeding programs because of their relevance for crop production. The final ripe fruit is the result of a process under multiple levels of regulation, including mechanisms orchestrated by microRNAs and lncRNAs. Most of the studies we discuss involve work on tomato and Arabidopsis. In this review, we summarize non-coding RNA-controlled mechanisms described in the current literature that act coordinating the main steps of gynoecium development/patterning and fruit ripening.\nFruits are plant organs found solely in angiosperms and are commonly defined as mature ovaries containing seeds. They are also ecologically defined as seed dispersal units, and their diversification and specialization are key events of the adaptive success of angiosperms in a wide range of environments (Seymour et al., 2013). The final characteristics of a mature fruit are determined by events that take place in developmental stages ranging from floral meristem initiation to later stages of fruit ripening. Complex mechanisms of transcriptional regulation of each of these stages ensure proper fruit development. After floral meristem initiation, key events of fruit development include carpel formation, differentiation, patterning and organ boundary formation. Ovule and seed development are also fundamental processes for the completion of fruit maturation. Fruit set occurs when the signaling triggered by the pollination and fertilization turns a fully developed ovary into a fast-growing fruit that will soon initiate the ripening process.\nAlthough physiological and molecular aspects of fruit development and ripening are well discussed in the available literature (Ferrándiz et al., 2010; Liu et al., 2015), few reviews focused on the role of non-coding RNA-based molecular regulation controlling early and late stages of fruit development. Here, we reviewed the literature focused on the aspects of the regulation by non-coding RNA in different stages of fruit development, including ovule and seed development. Moreover, we discussed aspects of fruit growth and ripening in the light of miRNA and lncRNA-associated mechanisms. One important question that need to be better addressed in future studies is how transcriptional control of fruit development is conserved between dry fruit-bearing and fleshy fruit-bearing species (e.g., Arabidopsis thaliana and tomato or Solanum lycopersicum, respectively). A better understanding of the non-coding RNA-related transcription hallmarks orchestrating early steps of fruit development and ripening in different species may have the potential to provide novel strategies for crop improvement.\nMicroRNA Modules Involved in Early Steps of Fruit Patterning and Growth\nThe carpel is the female reproductive organ that encloses the ovules in flowering plants. The gynoecium is the innermost floral whorl, formed by the fusion of carpels in the center of the flower. The hypothesis of the origin of the carpels as modified leaves is corroborated by the observation that leaf development-associated factors also have roles in carpel development (Dinneny et al., 2005; Scutt et al., 2006; Alonso-Cantabrana et al., 2007; Ferrándiz et al., 2010; González-Reig et al., 2012; Seymour et al., 2013; Deb et al., 2018). Carpel and fruit development can be broadly divided into two main temporal set of events: an earlier set of events that occur prior to fertilization (differentiation and patterning), and later events, which occur after fertilization (growth, ripening and senescence) (Ripoll et al., 2015; Deb et al., 2018). A fine-tuned molecular regulation of each of these developmental steps is crucial to ensure proper morphological and physiological characteristics of the mature fruit.\nMicroRNAs (miRNAs) and their targets (mostly transcription factors; Chen, 2009) are fundamental components of molecular modules (hereafter referred to microRNA modules) belonging to complex circuits that control various aspects of plant development. miRNAs inhibit the activity of their targets by two major mechanisms: ARGONAUTE1 (AGO1)-mediated transcriptional cleavage, and translational repression of gene targets (Borges and Martienssen, 2015). At cell and tissue levels, many miRNAs accumulate in a spatiotemporal manner to modulate and/or fine-tune the expression of their targets (Chen, 2009; Rubio-Somoza and Weigel, 2011). For instance, some miRNAs participate in tissue patterning by restricting the expression domain of target genes (Berger et al., 2009; Chen, 2009; Ripoll et al., 2015). On the other hand, miRNAs and targets may be co-expressed in similar domains, where miRNAs ensure proper transcript accumulation by dampening target transcript levels. In this case, miRNAs generally mediate the temporal control of transcript accumulation, in which cells and/or tissues exhibit a gradual decrease or increase in the levels of target transcripts as the organ develops (Aukerman and Sakai, 2003; Wu et al., 2010; Rubio-Somoza et al., 2014; Wang, 2014; Guo et al., 2017; He et al., 2018).\nSome miRNA modules had their roles in gynoecium and fruit development described in different model plants, such as A. thaliana, which produces dry fruits (silique), and tomato (S. lycopersicum), which produces fleshy fruit (berry). Interestingly, alterations in similar miRNA modules produce distinct phenotypic changes in gynoecium and fruits of Arabidopsis and tomato (Xing et al., 2013; Silva et al., 2014). Understanding what pathways are directly and/or indirectly regulated by similar miRNA modules in different species, and how they influence distinct fruit morphologies, will shed light on important evolutionary aspects of fruit development. In the next sections, we discussed examples in the literature concerning the roles of miRNA modules in early events of fruit development mostly in tomato and Arabidopsis.\nThe miR164 Module Controls Carpel Development and Leaf Margin Serration Through Similar Mechanisms\nMiRNA-associated pathways control many aspects of plant development. Some miRNA-targeted transcriptional regulators that had their roles previously associated with vegetative development, such as leaf development, had similar functions later elucidated in carpel development. For instance, Arabidopsis miR164-targeted CUP-SHAPED COTYLEDON1 and 2 (CUC1 and CUC2) – which belong to the NAC transcription factor family – regulate organ boundary during the separation between organ primordia and meristem, and control leaf margin serration (Laufs et al., 2004; Nikovics et al., 2006; Peaucelle et al., 2007; Hasson et al., 2011; Vialette-Guiraud et al., 2016). Earlier studies showed that CUC1 and CUC2 operate during the initial phase of organ initiation inhibiting cell growth in meristem-organ and organ–organ boundaries, facilitating the separation between adjacent vegetative and reproductive organs (Aida et al., 1999; Laufs et al., 2004; Mallory et al., 2004). In this process, miR164 defines boundary domains by restricting the expression of CUC1 and CUC2 (the miR164 module), and proper miR164 dosage and/or expression localization is required for organ separation. The miR164 module also operates further in organ development, when organ shape is being determined (Nikovics et al., 2006). In the margins of leaf primordia, CUC2 and MIR164A are spatially and temporally co-expressed, and the balance between their expression controls the degree of Arabidopsis leaf margin serration (Nikovics et al., 2006). This module operates similarly in the regulation of leaf complexity in tomato, in which the CUC2 ortholog miR164-targeted GOBLET (GOB) plays similar roles during boundary establishment leading to leaflet separation. Interestingly, the regulation of compound leaf development by the miR164 module is conserved in Aquilegia caerulea, Solanum tuberosum, Cardamine hirsuta, and Pisum sativum (Blein et al., 2008).\nLike its function in leaf development, the miR164 module is also expressed in the margins of carpel primordium during Arabidopsis gynoecium development, and it determines important morphological characteristics of the mature fruit (Ishida et al., 2000; Sieber et al., 2007; Nahar et al., 2012; Kamiuchi et al., 2014; Vialette-Guiraud et al., 2016). Arabidopsis gynoecium is formed by two carpels that are already initiated as two fused structures, except by the apical margins, which are fused later to form style and stigma (Sessions and Zambryski, 1995; Nahar et al., 2012). During early gynoecia development, the meristematic tissue called Carpel Margin Meristem (CMM) is originated in the margins of each carpel primordia and is responsible for producing the ovules, the ovary septum, the transmitting tract, and promoting fusion between the apical carpel margins (Alvarez and Smyth, 1999; Nahar et al., 2012; Vialette-Guiraud et al., 2016). Earlier studies showed that CUC1 and CUC2 expression is required for the activation of the KNOX type-I gene SHOOT MERISTEMLESS (STM) in different developmental contexts, such as the formation of shoot apical meristem during embryo development and leaf serration in Arabidopsis (Takada et al., 2001). In such processes, STM expression is required to establish and maintain meristematic tissues. The same mechanism seems to operate in the establishment and maintenance of CMMs during carpel development in Arabidopsis (Kamiuchi et al., 2014). Most cuc1cuc2 double mutants failed to form CMM, producing mature gynoecia with drastically reduced or complete loss of ovules and septum. Arabidopsis plants expressing miR164-resistant versions of CUC1 and CUC2 showed expanded domain of STM expression, resulting in carpel primordia with altered size and number of CMM, of which most initiated in altered positions. These plants produce mature fruits with internal filamentous structures (Kamiuchi et al., 2014). When not regulated by miR164, CUC1/2 expression is less precise and can expand out of the boundary strips, resulting in incorrect CMM positioning, which leads to carpel and fruit developmental aberrations.\nSPATULA (SPT) encodes a basic helix-loop-helix (bHLH) transcription factor, and Arabidopsis loss-of-function spt mutants produce ovaries with split or incomplete fused carpels and defective CMM-derived tissues (Heisler et al., 2001; Nahar et al., 2012). cuc1;cuc2 mutations partially suppress the split carpel phenotype of spt mutant, indicating that congenital carpel fusion depends on SPT-based down-regulation of CUC1 and CUC2. Thus, the coordinated interaction among SPT, CUC1, and CUC2 regulates Arabidopsis ovule and septum development during the progression of fruit growth (Nahar et al., 2012). It was recently shown that SPT enables cytokinin signaling, which provides meristematic properties to CMM. SPT seems to play a role in the interaction between auxin and cytokinin pathways, as SPT induces ARABIDOPSIS RESPONSE REGULATOR 1 (ARR1) directly. SPT and ARR1 induce the expression of the auxin transporter PIN-FORMED 3 (PIN3) and the auxin biosynthesis gene TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS 1 (TAA1, Reyes-Olalde et al., 2017).\nThe role of the tomato CUC2 homolog GOB was studied in detail during leaf development and complexity, although little is known about the function of GOB in reproductive development. Loss-of-function GOB mutant (gob-3) produces fruits with fewer locules, whereas gain-of-function GOB mutant (which contains a miR164-resistant version of GOB, the Gob-4d) displays fruits with extra carpels and increased number of locules (Berger et al., 2009). Since leaf complexity was the main objective of this work, no mechanism was proposed of how the miR164 node (miR164-targeted GOB) controls locule number in tomato fruits. On the other hand, tomato miR164-targeted NO APICAL MERISTEM 2 (SlNAM2), another member of the NAC transcription factor family, was shown to have an important role in organ boundary maintenance during floral development (Hendelman et al., 2013). Unlike GOB, SlNAM2 is not expressed in boundaries between floral meristem and organ primordia, as SlNAM2 expression was not detected before carpel fusion in flower buds. Data thus far suggest that GOB functions during the formation of the boundaries, being expressed at earlier stages of organ primordia development, whereas SlNAM2 is expressed at later stages of floral whorl development, being responsible for the maintenance of the boundaries established by GOB (Hendelman et al., 2013). Plants overexpressing mSlNAM2 (a miR164-resistant version of SlNAM2) produced gynoecia with shorter stamen and styles and wide pistil, the latter likely due to the extra carpel formation. Although weaker, mSlNAM2 phenotypes were similar to Gob-4d phenotypes, which is consistent with the proposed SlNAM2 role in boundary maintenance, but not boundary formation (Berger et al., 2009; Hendelman et al., 2013). In summary, the functions of the miR164 module in Arabidopsis and tomato gynoecium patterning illustrates the crucial importance of boundary formation and maintenance during fruit development. Proper function of the miR164 module is essential for the establishment and maintenance of gynoecium development, not only in syncarpous species such as Arabidopsis and tomato, but also in monocarpous species like Medicago truncatula (Berger et al., 2009; Vialette-Guiraud et al., 2016).\nThe Role of miR156/miR157 in Carpel and Fruit Development\nMiR156 targets members of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SBP/SPL) transcription factor family. In Arabidopsis and tomato, 11 out of 17 SBP/SPLs harbor the miR156 recognition site (Salinas et al., 2012; Preston and Hileman, 2013). The miR156 module (miR156-targeted SBP/SPLs) defines the evolutionary conserved age-dependent floral pathway in several plants, including tomato (Silva et al., 2018). Interestingly, the miR156 module has been proposed as a main target for crop improvement, aiming to enhance agronomic traits such as the timing of vegetative and reproductive phase change, leaf development, tillering/branching, panicle/tassel architecture, fruit development and fertility (Wang and Wang, 2015).\nIn terms of gynoecium and fruit development, it was demonstrated that Arabidopsis SPL8 (which is not targeted by miR156) acts redundantly with miR156-targeted SPLs in the control of carpel development (Xing et al., 2013). Transgenic plants overexpressing miR156 (p35S::MIR156b) produce flowers with reduced ovary size but unaffected structure, while ovaries of spl8-1 mutant show a slight reduction in size and resembles wild-type (WT). Conversely, the double mutant p35S::MIR156b spl8-1 show extremely modified gynoecia. The gynoecium shape of p35S::MIR156b spl8-1 is completely altered, displaying an enlarged upper region and a narrower basal region, abnormal septum development, and absence of transmitting tissue to support pollen tube growth into the ovary (Xing et al., 2013). Considering that SPL8 and the miR156-targeted SPLs 2, 6, 10, 11, and 13 are expressed in overlapping domains during gynoecium development, this data supports the idea that they have partly redundant roles in the patterning of the gynoecium and fruit development. Furthermore, seed production decreased about 60% in p35S::MIR156b plants in comparison with WT and spl8-1 (which show unaltered seed production), whereas p35S::MIR156b spl8-1 produces approximately 96% less seeds than WT (Xing et al., 2013). Together, these data indicate that the function of at least one of these SPLs is crucial for proper gynoecia development. Another study showed that Arabidopsis squint (sqn) mutants contain loss-of-function alleles for Cyclophilin40 (CyP40), which increases the activity of miR156 by promoting AGO1 activity. sqn plants showed elevated expression of miR156-targeted SPLs and produce siliques with increased carpel number (Smith et al., 2009).\nInterestingly, the miR156 module may function by different mechanisms or have different roles in dry fruit and fleshy fruit-bearing species. As mentioned above, ovaries of Arabidopsis p35S:MIR156b plants do not present extra carpels or undetermined growth (Xing et al., 2013). On the other hand, the overexpression of miR156 (p35S:MIR156b) in tomato plants led to the production of extremely modified ovaries formed by multiple fused extra carpels and undifferentiated tissue inside the post-anthesis ovaries (Silva et al., 2014). After fruit set, the undifferentiated tissue inside the ovaries of p35S:MIR156b plants continues to grow, forming fruit-like structures growing from the stylar end of the fruits. Furthermore, mature fruits show increased number of locules due to the presence of extra carpels in the ovary (Figure 1; Silva et al., 2014). Floral identity genes like FUL1/TDR4, FALSIFLORA (FA, Arabidopsis LEAFY ortholog; Lozano et al., 2009) and MACROCALLYX (MC, Arabidopsis APETALA1 ortholog; Lozano et al., 2009) were strongly down-regulated in tomato p35S:MIR156b ovaries (Silva et al., 2014). Arabidopsis FUL, AP1 and LFY are direct targets of SPL3 (Yamaguchi et al., 2009), although it is still unknown whether their tomato orthologs are direct targets of SlSBP3. Interestingly, the CUC2 and STM orthologs GOB and TKN2, respectively, are up-regulated in tomato p35S:MIR156b ovaries. MiR164-targeted GOB and TKN2 are associated with leaf complexity in tomato but both can also regulate the number of locules per fruit (Parnis et al., 1997; Berger et al., 2009). This finding indicates a link between miR156 and miR164 modules and suggests that tomato miR156 module controls boundary formation and establishment as well as locule number through GOB and perhaps other NAC domain-containing genes (such as SlNAM2). As expected, tomato plants overexpressing miR164 lead to GOB down-regulation and the production of fruits with normal shape but reduced locule number (Silva et al., 2014).\nFIGURE 1. MIR156 overexpression alters tomato fruit determinacy and locule number. (Upper) Wild-type (WT) fruits and undetermined p35S::MIR156b fruits. (Lower) Three-locular WT fruits and four-locular p35S::MIR156b fruits. Bars: 1 cm.\nMost plant genomes also contain miR157, a miR156 closely related miRNA which differs from miR156 by three nucleotides (Reinhart et al., 2002). MiR157 overexpression in Arabidopsis generates plants phenotypically similar to miR156 overexpressors, but miR157 specific functions are still unknown (He et al., 2018). MiR157 seems to be more abundant but less effective on SBP/SPL repression, perhaps because it is less efficiently loaded onto AGO1 (He et al., 2018). Transgenic cotton plants overexpressing miR157 produced smaller gynoecium, with less ovules per ovary and decreased seed production in comparison with WT (Liu et al., 2017). These plants showed reduced expression of two MADS-box transcription factors (orthologs of AtAGL6 and SlTDR8). In addition, auxin response was attenuated in ovaries of miR157-overexpressing cotton plants. It is possible that miR156 and miR157 modules regulate gynoecium development by overlapping but also specific mechanisms, although additional studies are needed to unravel miR157 specific functions in reproductive development.\nmiR396 Module Regulates CMM Meristematic Competence and Pluripotency During Gynoecium Development\nThe GROWTH-REGULATING FACTORs (GRFs) belong to a plant-specific transcription factor family that has nine members in Arabidopsis, seven of which (GRF1, GRF2, GRF3, GRF4, GRF7, GRF8, and GRF9) are targeted by miR396, representing the miR396 module (Liang et al., 2014; Lee et al., 2014, 2017). MiR396 module regulates several developmental processes, such as leaf development, floral development, and root cell reprograming during nematode infection (Lee et al., 2009; Hewezi et al., 2012).\nArabidopsis plants overexpressing miR396 (p35S:MIR396a) show gynoecium developmental defects such as gynoecia formed by only one carpel and siliques (dry fruits) producing a reduced number of seeds (Liang et al., 2014; Lee et al., 2017). Arabidopsis GRFs interact physically in the nucleus with the transcriptional co-activators GRF-INTERACTING FACTOR1, 2 and 3 (GIF1, GIF2, and GIF3) (Liang et al., 2014). Because GIF-GRF complexes are crucial for meristematic competency and pluripotency of CMM cells (Lee et al., 2017), high miR396 levels may lead to low GRFs available to form these heterodimers, hence CMM loses its meristematic competence and pluripotency over time (Liang et al., 2014; Lee et al., 2017). Single GRF loss-of-function mutants produce WT-like siliques, whereas gif1 single mutant produces normal pistil and siliques but with reduced size. Siliques of the double transgenics p35S:MIR396a;p35S:mGRF7 and p35S:MIR396a;p35S:mGRF9 (both expressing miR396-resistant versions of GRF7 and 9 transcripts, respectively) can recover WT silique phenotypes, indicating that at least miR396-targeted GRF7 and 9 have roles in fruit development (Liang et al., 2014). The phenotypes of gynoecium and siliques of the triple mutant gif1 gif2 gif3 phenocopy those of the double mutant p35S:MIR396a grf5 (GRF5 is not targeted by miR396), producing extremely short and almost sterile siliques, generally lacking valves, whereas some GRF triple mutants (e.g., grf1/grf2/grf3 and grf7/grf8/grf9) present WT-like siliques (Liang et al., 2014). The triple mutant grf1 grf3 grf5 show single-valve gynoecia and slight defects on floral organ separation and number, but these defects were strongly enhanced by the addition of grf2 mutation to this background (generating the quadruple mutant grf1grf2 grf3 grf5). Together, these findings indicate that GRFs act redundantly to modulate Arabidopsis gynoecium patterning and fruit development.\nThe mechanisms by which GRF-GIF dimers promote CMM meristematic capacity in Arabidopsis gynoecium were not well elucidated, but available data suggest that they may be associated with polar auxin transport (PAT) (Lee et al., 2017). Arabidopsis PAT mutants (pin-formed1 and pid) and some auxin biosynthesis mutants (yuc1, yuc4 and wei8 tar2) produce gynoecia phenotypes identical to gif p35S:MIR396a plants and grf multiple mutants. The addition of gif mutations to a pid-3 mutant (a PINOID mutant with weak developmental defects) or treatment of gif mutants with N-1-Naphthylphthalamic Acid (NPA, an auxin polar transport inhibitor) synergistically enhance gynoecium developmental defects of pid-3 or NPA-treated WT plants (Lee et al., 2017). These findings indicate an interplay between miR396, GRF-INTERACTING FACTORs and auxin during gynoecium patterning.\nUnlike Arabidopsis, the possible role of the miR396 module in tomato fruit development has not been described in detail. The only study in tomato thus far showed that miR396 down-regulation (or GRF de-regulation) seems not to affect CMM formation but rather it leads to a significant increase in fruit size (Cao et al., 2016). This is consistent with the main role of GRFs in modulating cell proliferation and cell expansion in several developmental contexts (Lee et al., 2009). Since neither fruit shape nor ripening was altered in the transgenic tomato plants down-regulating miR396 (Cao et al., 2016), the authors proposed that these plants might provide a new way to enhance tomato fruit yield.\nMicroRNA160 Module Controls Carpel Development by Modulating Auxin Responses\nSome microRNAs, such as miR160, are crucial for auxin signaling during several developmental processes. MiR160, which targets the AUXIN RESPONSE FACTORS ARF10, 16, and 17 (Hendelman et al., 2013; Damodharan et al., 2016), is another example of a miRNA module that apparently has different roles in the regulation of dry and fleshy fruit development.\nThe Arabidopsis floral organs in carpels (foc) mutant contains a Ds transposon insertion in the 3′ regulatory region of the MIR160a gene, which disrupts its native expression pattern, leading to the accumulation of ARF10, 16, and 17 and low auxin responses in various organs (Liu et al., 2010). These regulatory disruptions lead to abnormal embryo, seed, and flower development. foc plants show some degree of indeterminacy during gynoecium patterning, which is observed by the production of floral organs inside the siliques and sometimes whole inflorescences emerging from siliques. Furthermore, foc mutant produces abnormal seeds and viviparous seedlings. It was also shown that 3′ regulatory region bears three putative auxin-responsive elements (AuxRE) and MIR160a expression is positively regulated by auxin. Thus, the disruption of this regulatory region impairs the induction of MIR160a expression by auxin, impacting fruit development (Liu et al., 2010).\nThe miR160 module (miR160 and their targets) seems also to have an important, but different, role in tomato fruit development. Transgenic tomato plants (STTM160-expressing plants) with knocked-down miR160 expression generated by the Short Tandem Target Mimic (STTM) approach (Teotia and Tang, 2017) produce ovaries with elongated morphology and thinning of the placenta, which developed into fruits with abnormal pear-shaped fruit morphology. These changes were associated with miR160 depletion and concomitant de-regulation of SlARF10B and SlARF17, and mostly SlARF10A in STTM160-expressing plants (Damodharan et al., 2016). Nevertheless, unlike Arabidopsis foc mutant, no indeterminacy was observed in gynoecia of STTM160-expressing tomato plants. Such discrepancy between phenotypes of tomato and Arabidopsis miR160 loss-of-function plants may be due to the fact that SlARF16 is not de-regulated in STTM160-expressing tomato plants, despite the miR160 legitimate site observed in SlARF16 (Damodharan et al., 2016).\nMiR160-guided cleavage of some ARFs is also needed for proper leaf development in tomato and Arabidopsis. Interestingly, STTM160 tomato plants and 5mARF17 (plants expressing a miR160-resistant version of ARF17) Arabidopsis plants showed similar leaf phenotype, which is reduced leaf blade and strongly lobbed leaflet/leaf margins (Mallory et al., 2005; Damodharan et al., 2016).\nmiR172 Limits the Growth-Repressing Activity of APETALA2-Like Genes During Fruit Expansion\nAll microRNA modules discussed so far are mostly associated with very early stages of carpel development, such as patterning and differentiation, and the proper control of these stages have great impact on mature fruit morphology and fertility. On the other hand, the miR172 module seems to control not only fruit patterning, but also fruit growth, which comprises a developmental stage after pollination, when the ovary is fully developed. In Arabidopsis, the miR172 module comprises the microRNA172 and its targets [APETALA2-LIKE (AP2-like) transcription factors]: APETALA2 (AP2), TARGET OF EAT1, 2 and 3 (TOE1, TOE2, and TOE3), SCHLAFMUTZE (SMZ), and SCHNARCHZAPFEN (SNZ) (Wu et al., 2010). Interestingly, pioneer studies showed that miR172 can guide not only AP2-like transcript degradation but also its translational repression (Chen, 2004).\nArabidopsis fruit undergoes dramatic increase in fruit size after fertilization, and different tissues grow at different rates (for review please see Ferrándiz et al., 2010). MiR172 module seems to be crucial to specify which regions of the carpel will go through dramatic expansion and which region will arrest fruit growth. AP2 encodes an AP2/EREBP transcriptional repressor, which was shown to repress valve margin and replum growth post-fertilization by repressing the expression of genes that confer identity to valve margin (INDHEISCENT and SHATTERPROOF) and replum (BREVIPEDICELLUS and REPLUMLESS) (Ripoll et al., 2011). In this context, AP2 prevents replum overgrowth and overproliferation of the layer of lignified cells (LL) (which are associated with fruit dehiscence; Rajani and Sundaresan, 2001; Liljegren et al., 2004) in the valve margin. Consistent with this, ap2 mutants produce siliques with oversized replum and slightly delayed dehiscence due to increased number and size of LL (Ripoll et al., 2011). Nevertheless, after pollination the valves undergo a conspicuous cell expansion stage, increasing dramatically fruit size. This pollination-dependent valve growth was shown to be blocked in plants with decreased miR172 activity – via target mimicry (MIM172) approach (Franco-Zorrilla et al., 2007) – and in plants expressing a miR172-resistant AP2 version, resulting in smaller fruits (Ripoll et al., 2015). For proper valve expansion, AP2 and TOE3 activities must be inhibited by miR172 only in the valves. The MAD-box transcription factor FRUITFULL (FUL) displays similar expression pattern as miR172, being expressed in the valves, and ful mutants resemble MIM172 plants, presenting arrested growth phenotype in the valves. Furthermore, analysis of different degrees of homo and heterozygosity of ARF6 and ARF8 mutant alleles arf6 and arf8 in double mutants show that fruit valve expansion decreases with the increasing ARF mutant allelic dosage. Valve growth is even more limited when arf6/8 are introduced in ful, and arf6 arf8 ful triple mutants produce siliques with extremely impaired growth. FUL, ARF6, and ARF8 are expressed only in the valves (except valve margins), where they form protein complexes that bind to the MIR172C promoter and activate its expression. AP2 and TOE3 are expressed in the whole carpel, but miR172 induction in the valves restricts AP2 activity to the valve margins and replum, allowing it to repress cell elongation in these locations but not in the valves. Through this mechanism, miR172 fine-tunes fruit patterning and growth by restricting the activity of AP2-like genes to certain locations within the fruit (Ripoll et al., 2015). Considering that miR167 negatively regulates ARF6 and ARF8 (Wu et al., 2006), it will be interesting to determine whether this miRNA participates in this mechanism by specifying ARF6/8 expression pattern.\nAlthough high levels of miR172 have a positive effect on Arabidopsis fruit growth (Ripoll et al., 2015), this is not always the case for other species. For instance, over-expression of a MIR172 gene has a negative influence on fruit growth in apple (Malus domestica), resulting in a dramatic reduction in fruit size (Yao et al., 2016). Unlike Arabidopsis and tomato fruits, which are both derived from ovaries, apple fruits are mostly derived from the hypanthium that is hypothesized to consist of the fused bases of the sepals, petals, and stamens (Pratt, 1988). Interestingly, over-expression of the same MIR172 gene in tomato results in carpel-only flowers which developed into parthenocarpic fruits (Yao et al., 2016). These examples nicely illustrate that the influence of a particular miRNA module on fruit growth depends on the fruit type and plant species.\nMicroRNA-Controlled Pathways Modulating Ovule and Seed Development During Fruit Growth\nThe ovule is the female sexual organ in higher plants and a strict control of ovule development is crucial for plant reproductive success. Ovule is required to enclose the female gametophytes and, more importantly, it is from the fertilized ovules that seeds arise. Ovule structures are conserved in most plants, and comprise the embryo sac, the nucellus, the integument (which originates the seed coat) and the funiculus, which makes the connection between the ovule and placenta. Ovule and seed development are under control of genetic (e.g., transcription factors, non-coding RNAs), physiological (hormones) and epigenetic factors (i.e., chromatin remodeling and DNA methylation) (Skinner et al., 2004; Kelley and Gasser, 2009; Yamaguchi et al., 2013; Cucinotta et al., 2014). In this part of the review, we will discuss the findings of how some small RNAs modules act to modulate ovule and seed development, which are crucial developmental processes that take place during fruit development and ripening.\nIt was recently shown by our research group that the miR159 module is crucial for ovule and seed development in tomato (da Silva et al., 2017). The miR159 module comprises the microRNA159 and its targets, SlGAMYB1 and SlGAMYB2, which belong to the R2R3 MYB domain transcription factor family. GAMYB-like genes are regulated by gibberellin and by the microRNA159 family in different tissues and developmental contexts (Gubler et al., 1995; Tsuji et al., 2006; Alonso-Peral et al., 2010). MiR159 and its targets are expressed early during tomato placenta and ovule development, which suggest that the miR159 module may be involved in the initial steps of ovule development. Likewise, the overexpression of SlMIR159 (p35S::SlMIR159) disrupts ovule development and induces obligatory parthenocarpy. Such phenotype is more severe than what is shown in AtMIR159a-overexpressing Arabidopsis plants, which generates fertile siliques when pollinated with WT pollen (Achard et al., 2004). Tomato, transgenic plants harboring the p35S::SlMIR159 construct displays defects in the establishment of the embryo sac, which may be due to the observed lower expression of AINTEGUMENTA-like genes (da Silva et al., 2017). AINTEGUMENTA (ANT) gene is an APETALA2-like transcription factor required for ovule and integument initiation (Elliott et al., 1996). Although tomato lacks known ANT mutants, it was shown in rice that ANT was also strongly repressed in gamyb mutants displaying ovule developmental defects (Tsuji et al., 2006). MiR159 module interacts with tomato AINTEGUMENTA-like genes to drive developmental progression of ovules and, thus, modulates tomato fruit set. Moreover, our work showed that miR159 module interacts with the miR167 module. Down-regulation of miR167 and concomitant SlARF8 de-regulation in p35S::MIR159 plants may be also responsible for the arrested ovule development (da Silva et al., 2017), illustrating the link between the miR159 module and auxin during fruit set.\nParthenocarpy, the developmental process in which fruits develop in the absence of fertilization (Varoquaux et al., 2000), can be easily induced in grapevine (Vitis vinifera) by exogenous gibberellin (GA) application (Wang C. et al., 2018). These authors show that VvmiR159c and its target VvGAMYB are dynamically and opposing expressed during flowering and fruit set. GA treatment is capable of inducing VvmiR159c and, consequently, down-regulating VvGAMYB in reproductive organs. These observations led the authors to suggest that the miR159 module is associated with GA-induced parthenocarpy in grapevine (Wang C. et al., 2018), similarly to what we have discovered in tomato (da Silva et al., 2017).\nThe use of high-throughput sequencing approaches also provided evidences of the activity of miRNA modules during ovule development. In cotton (Gossypium hirsutum), small RNAs profiles of developing ovaries showed distribution of several small RNA signatures, including microRNAs (Abdurakhmonov et al., 2008). Several conserved microRNA families were identified in cotton ovules, including miR156/157, miR159, miR164, miR168, and miR395. These results are important to provide initial information for future functional experiments. In addition, several predicted miRNA targets were validated via degradome sequencing (a modified version of 5′-Rapid Amplification of cDNA Ends that is combined with high-throughput, deep sequencing to detect transcript ends; Ma et al., 2015), reinforcing the idea that conserved miRNA modules may be important in ovule development of cotton (Xie et al., 2015).\nMicroRNAs are also required for embryogenesis, which is a key developmental step for plants to establish the seed set. To complete its development, the embryo undergoes specific stages, which in Arabidopsis are defined by its morphology as globular, heart, torpedo, and walking stick stages (Jürgens, 2001). Such developmental stages are known to be regulated by transcription factors, small regulatory RNAs, signal transduction orchestrated by kinases, auxin gradients, and epigenetic mechanisms (i.e., DNA methylation, histone acetylation, among others). Thus, these regulatory pathways are key determinants of the fate of primordia cell lineages, and also drive inheritance that is programmed via mitosis at early stages of the embryo development (Willemsen and Scheres, 2004).\nDICER-LIKE1 (DCL1) is a key enzyme for the pri-/pre-miRNA processing (Reinhart et al., 2002; Kurihara and Watanabe, 2004; Park et al., 2005). Genome-wide transcriptional profiling of the Arabidopsis mutant dicer1 (dcl1) shed some light regarding the importance of microRNA modules during early embryo development. At the early globular stage, dcl1 embryo display about 50 miRNA targets de-repressed due to the lack of miRNA regulation. Some of these targets (usually transcription factors) are required for differentiation at later stages of embryogenesis (Nodine and Bartel, 2010). In addition, in dcl1 embryos, miR156-targeted SPL10 and SPL11 are highly up-regulated, which suggest that the de-regulation of these transcription factors is at least in part responsible for the dcl1 embryo abnormalities (morphological defects and arresting growth at the globular stage). Thus, one of the first roles of plant microRNAs is to repress its targets at early developmental stages to prevent precocious differentiation during embryogenesis (Nodine and Bartel, 2010). This idea is further supported by the finding that Arabidopsis double mutant ago1/ago10 displays embryo lethality, probably due the highly activity of small RNAs targets (Lynn et al., 1999; Mallory et al., 2009). Argonaute (AGO) proteins are part of the RNA-induced silencing complex (RISC), and are required for the repression of microRNA targets (Rhoades et al., 2002; Zilberman et al., 2003).\nMiRNA module may also affect seed development. MiR397 negatively regulates members of the Laccase family. MiR397-targeted Laccase4 is a member of the blue copper oxidase/p-diphenol:dioxygen oxidoreductase family and participates in lignin biosynthesis (Gavnholt and Larsen, 2002; Mayer and Staples, 2002). The miR397/Laccase4 module has been implicated in the control of the number of seeds and seed size. Overexpression of MIR397b in Arabidopsis leads to reduce lignin deposition. Interestingly, in terms of fruit development, transgenic plants with less lignin produce bigger siliques with more and enlarged seeds. Similar results are observed in transgenic rice plants overexpressing MIR397a and MIR397b, which are able to produce enlarged grains (Zhang et al., 2013; Wang C.J. et al., 2014). Such studies highlight that miR397-mediated development via regulating laccase genes might be a potential tool not only for engineering plant biomass production with less lignin, but also for manipulating plant seed yield.\nNon-Coding RNAs in the Regulation of Fruit Ripening\nIn the first section of this review, we discussed the main microRNA modules involved in diverse aspects of early fruit development, which is summarized in Figure 2A. In this last section, we will discuss a few examples available in the literature that reinforce the fundamental roles of non-coding RNA-mediated regulation also in fruit ripening.\nFIGURE 2. Non-coding RNA networks associated with carpel patterning and fruit ripening. (A) Summary of miRNA modules that control early (e.g., CMM establishment and maintenance) and late aspects of Arabidopsis fruit development. MiR396 and miR164 modules have important regulatory roles in CMM maintenance. MIR172C is induced by AUXIN RESPONSE FATORS ARF6/8 and FRUITFULL (FUL) specifically in the valves, and this specificity is necessary for proper fruit growth after pollination. MiR172-guided APETALA2 (AP2) mRNA cleavage in the valves (but not valve margins) promotes valve growth due to the repression of AP2 growth-blocking activity. Growth is blocked by AP2 in valve margins and replum, where miR172 is not expressed. 1 – stigma, 2 – style, 3 – valve, 4 – Valve margin, 5 – replum, 6 – septum, 7 – ovule, 8 – carpel margin meristem (CMM). GRF, GROWTH-REGULATING FACTOR; GIF, GRF-INTERACTING FACTOR; STM, SHOOT MERISTEMLESS; CUC1/2, CUP-SHAPED COTYLEDON1 and 2. (B) Graphic shows the accumulation of miRNA-cleaved transcripts of COLORLESS NON-RIPENING (CNR) and APETALA2 (AP2) through four stages of fruit development/ripening: 5 days after pollination (5 DAP), Mature green (MG), Breaker (Br), and Red ripe (RR) (adapted from Karlova et al., 2013). MRNA cleaved product accumulation occurs in the breaker stage, coinciding with an ethylene peak production. Lnc1840 and lnc1459: long non-coding RNAs. Black lines in the transcriptional networks denote direct regulation, whereas gray lines denote indirect regulation. Question mark denotes that is uncertain if CNR forms a complex with RIN. SlCTR4, tomato CONSTITUTIVE TRIPLE RESPONSE 4.\nConserved and Solanaceae-Specific miRNA Modules Control Tomato Fruit Ripening\nTomato plants bearing the dominant mutation Cnr (COLORLESS NON-RIPENING) produce fruits with characteristics associated with impaired ripening, such as inhibited softening, yellow skin, and pericarp lacking pigments because of the arrested biosynthesis of ripening-related pigments (Thompson et al., 1999). Furthermore, mutant plants produce lower amounts of ethylene and exogenous ethylene application does not recover this phenotype. Positional cloning showed later that a SPL/SBP gene (called SlSBP3/CNR) containing a potential miR156/157 binding site resides in the Cnr locus. Cnr is an epimutation caused by spontaneous heritable hypermethylation of cytosine residues of the SlSBP3/CNR promoter, leading to SlSBP3/CNR repression (Manning et al., 2006). Although the mechanism by which SlSBP3/CNR controls fruit ripening remains unclear, recent data suggest that the MADS-box transcription factor RIPENING INHIBITOR (RIN) and CNR may be part of the same protein complex that induces the expression of ripening-related genes (Martel et al., 2011). RIN controls both ethylene-dependent and independent ripening regulatory pathways, interacting directly with the promoter of many known genes associated with key ripening processes, such as ethylene biosynthesis, perception and signal transduction, cell wall metabolism, and carotenoid biosynthesis. Nevertheless, CNR is required for RIN promoter binding activity, as RIN does not interact with the promoters of ripening-related genes in the Cnr mutant (Martel et al., 2011; Qin et al., 2012; Fujisawa et al., 2013). Although CNR and RIN proteins do not interact, it is possible that these transcription factors are part of the same protein complex that modulates the expression of key ripening genes. Substantiating this hypothesis, rin and Cnr mutants have similar fruit phenotypes such as blocked ripening and impaired response to exogenous ethylene (Vrebalov et al., 2002; Martel et al., 2011).\nVirus-induced gene silencing (VIGS)-based delivery of mature miR157 in tomato fruits reduced CNR transcript accumulation and delayed ripening in the injected fruit areas (Chen et al., 2015). Degradome analyses indicate that miR156 cleaves CNR in different stages of fruit ripening (Karlova et al., 2013). Surprisingly, VIGS-based delivery of miR156 does not produce any alteration in fruit ripening until the breaker stage, and these fruits show early softening (Chen et al., 2015). These observations suggest that the miR156/miR157 module may be necessary for proper control of fruit ripening and that the closely related miR156 and miR157 play different roles in the temporal control of the ripening-associated processes.\nTomato miR172-targeted AP2a appears to have complex functions in the control of diverse ripening-related processes, regulating mostly genes associated with ethylene biosynthesis and signaling (Karlova et al., 2011). AP2a silencing through RNAi leads to the production of fruits that ripe, but never turn from orange to red, showing altered levels of various carotenoids and increased chlorophyll levels, although they produce high levels of ethylene. AP2a seems to act downstream to RIN and CNR, as its expression is negatively regulated in rin and Cnr mutants and CNR binds to AP2a promoter. Thus, CNR induces AP2a expression directly, although AP2a represses CNR expression in a negative feedback loop (Karlova et al., 2011). Taken together, the evidences in tomato thus far indicate that both miR156/miR157 and miR172 modules and the interaction between their targets (CNR and AP2a) are important to proper fruit ripening. In fact, degradome analysis showed that levels of the CNR and AP2a miRNA-guided cleavage products vary among different ripening stages, showing peak accumulation of cleavage transcripts during breaker stage, which is also the peak of ethylene production (Karlova et al., 2013). It will be interesting to determine whether these miRNAs have specific roles in fine-tuning spatially and/or temporally the expression of their targets during fruit ripening.\nRecently, a novel miRNA identified as Solanaceae-specific was implicated in regulating ethylene signaling and hence fruit ripening in tomato (Wang Y. et al., 2018). The microRNA miR1917 targets three splicing variants of the CONSTITUTIVE TRIPLE RESPONSE 4 (SlCTR4, homolog of Arabidopsis CTR1), an ethylene signaling repressor that interacts with ethylene receptors (Wang Y. et al., 2018). Tomato plants overexpressing the miR1917 (p35S::MIR1917) display higher levels of ethylene signaling, leading to enhanced ethylene production. These plants also have increased ethylene responses in the absence of ethylene, including accelerated pedicel abscission and fruit ripening (Wang Y. et al., 2018). The complementary expression pattern of miR1917 and the splicing variants SlCTR4sv3 observed in the pedicel abscission zone by in situ hybridization suggests that miR1917 restricts the expression of its targets to the vascular bundle and surrounding cells during pedicel abscission. Thus, miR1917 and its targets represent a novel miRNA module belonging to the intricate ethylene-associated signaling network.\nNew Evidences of the Role of Long Non-coding RNAs (lncRNAs) in Fruit Ripening\nLong non-coding RNAs are broadly present in plant, animal and fungi transcriptomes and emerging evidences show that they play key roles in diverse developmental processes. They are RNAs longer than 200 nt originated from transcription of intergenic regions, introns or antisense coding sequences and do not have any detecting coding potential (Chekanova et al., 2007; Kapranov et al., 2007; Fatica and Bozzoni, 2014; Chekanova, 2015). LncRNAs may modulate gene expression by multiple mechanisms that were extensively reviewed in Chekanova (2015). Although the knowledge of the regulatory roles of lncRNAs in plants is still limited, lncRNAs have been associated with the control of flowering time, male sterility, seedling morphogenesis and, more recently, fruit ripening (Ding et al., 2012; Wang Y. et al., 2014; Berry and Dean, 2015; Li R. et al., 2018).\nRNA-seq analyses comparing transcriptomes of tomato cv Ailsa Craig and rin fruits identified over 3000 tomato lncRNAs, several of which were differentially expressed in rin (Zhu et al., 2015). In the same study, two lncRNAs (lncRNA1459 and lncRNA1840) strongly down-regulated in rin were chosen for VIGS-based silencing assays in fruits. Silencing of both lncRNAs produced non-ripening sections in the injected areas of the fruit, similarly to the effect observed in VIGS-based silencing of RIN. To better understand the functional role of lncRNA1459, which is a sense intergenic lncRNA, Li R. et al. (2018) generated loss-of-function mutants for lncRNA1459 using clustered regularly interspaced short palindromic repeats (CRISPR)/-associated protein 9 (Cas9)-induced genome editing technology (Feng et al., 2013; Doudna and Charpentier, 2014). Mutant fruits display delayed ripening phenotype associated with repressed ethylene and carotenoid biosynthesis, as well as down-regulation of ripening-associated genes.\nIn addition to tomato, lncRNAs involved in fruit ripening have been identified and studied in few other species. Sea buckthorn (Hippophae rhamnoides) is a plant for land reclamation, and its berry-type fruits have high nutritional value due to the significant amounts of natural anti-oxidants including ascorbic acid, tocopherols, carotenoids, and flavonoids (Zakynthinos et al., 2016). By using high throughput RNA sequencing, Zhang et al. (2018) identified over 9000 lncRNAs expressed in distinct sea buckthorn fruit developmental stages, from mature green to red-ripe. Interesting, the authors identified two lncRNAs (LNC1 and LNC2) that may function as target mimics of miR156 and miR828 during fruit ripening, therefore indirectly affecting the expression of these miRNA targets, SPL9 and MYB114, respectively. By modulating SPL9 and MYB114 expression, LNC1 and LNC2 seem to control the biosynthesis of anthocyanin during fruit ripening (Zhang et al., 2018).\nDespite the examples given above, the functions of the majority of ripening-associated lncRNAs are still unclear. More functional studies are needed to confirm the function of lncRNAs and their possible target genes. On possibility to be further explored is that lncRNAs can interact with microRNAs to modulate gene expression level (Gorospe et al., 2014), thus combining the “power” of two ncRNAs to modulate fruit ripening (Figure 2B).\nDuring plant development, multiple microRNA modules are required to control meristem identity, leaf margin serration, polarity, complexity, root development, and flowering time. As summarized here, miRNA modules have key roles in fruit development, ranging from carpel establishment and patterning to fruit ripening. Disruption of miRNA transcription or processing frequently generate pleotropic consequences for the plant. Indeed, their activity are essential for plants to complete their life cycle, since they are active from seed to flower production. Interestingly, evolution of miRNA modules brought about adaptative advantages to plants by using similar pathways to orchestrate different developmental processes. A good example presented here is the miR164 module, which is required for proper leaf and carpel/fruit development, corroborating the hypothesis of the evolutionary origin of carpel as modified leaves. It is interesting to consider that evolution has also hijacked similar microRNAs modules to control unrelated developmental programs such as the role of the miR156 module in flowering time and fruit development and ripening. In addition, due to their multiple roles in plant development, microRNA modules may also provide promising molecular tools to be explored in an agricultural context. Therefore, the better understanding of the mechanisms that control miRNA and target expression and their spatiotemporal regulatory roles could be an outstanding step toward the application of microRNA-targeted regulation of important fruit traits, including size, shape, seed production, and ripening. For instance, the use of novel CRISPR/Cas9-based technologies (Li C. et al., 2018) might allow subtle changes in miRNA target gene expression which have a potential to quantitative modify fruit traits. Additionally, it would be interesting to investigate whether there are more specific microRNAs modules (e.g., Solanaceae-specific microRNA mentioned in this review) in others crops that might be associated with fruit quality traits. Although there are open questions of how microRNA modules function during fruit development, lncRNA-associated pathways are probably one of the less understood so far, involving multiple and complex origins and modes of action. As mentioned in this review, microRNAs and lncRNAs act during fruit ripening, and they can interact during this process. In addition, since they may have overlapping functions during ripening, it would be interesting to investigate whether these two classes of non-coding RNAs interact in early steps of carpel development and fruit patterning as well. The identification of additional lncRNAs and miRNAs and the understanding of how they interact with each other to control fruit development and ripening would be an important step toward the improvement of fruit production. The use of next generation sequencing technologies combined with functional genomics may help to achieve this goal.\nJC, ES, and FN conceived the review. JC and ES wrote the review. 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The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis. Cell 138, 750–759. doi: 10.1016/j.cell.2009.06.031\nWu, M. F., Tian, Q., and Reed, J. W. (2006). Arabidopsis microRNA167 controls patterns of ARF6 and ARF8 expression, and regulates both female and male reproduction. Development 133, 4211–4218. doi: 10.1242/dev.02602\nXing, S., Salinas, M., Garcia-Molina, A., Höhmann, S., Berndtgen, R., and Huijser, P. (2013). SPL8 and miR156-targeted SPL genes redundantly regulate Arabidopsis gynoecium differential patterning. Plant J. 75, 566–577. doi: 10.1111/tpj.12221\nYamaguchi, A., Wu, M. F., Yang, L., Wu, G., Poethig, R. S., and Wagner, D. (2013). A molecular framework for auxin-mediated initiation of flower primordial. Dev. Cell 17, 268–278. doi: 10.1016/j.devcel.2009.06.007\nYamaguchi, A., Wu, M. F., Yang, L., Wu, G., Poethig, S. R., and Wagner, D. (2009). The microRNA-egulated SBP-box transcription factor SPL3 is a direct upstream activator of LEAFY, FRUITFULL, and APETALA1. Dev. Cell 17, 268–278. doi: 10.1016/j.devcel.2009.06.007\nYao, J. L., Tomes, S., Xu, J., and Gleave, A. P. (2016). How microRNA172 affects fruit growth in different species is dependent on fruit type. Plant Signal. Behav. 11:e1156833. doi: 10.1080/15592324.2016.1156833\nZakynthinos, G., Varzakas, T., and Petsios, D. (2016). Sea buckthorn (Hippophae rhamnoides) lipids and their functionality on health aspects. Curr. Res. Nutr. Food Sci. 4, 182–194. doi: 10.12944/CRNFSJ.4.3.04\nZhang, G., Chen, D., Zhang, T., Duan, A., Zhang, J., and He, C. (2018). Transcriptomic and functional analyses unveil the role of long non-coding RNAs in anthocyanin biosynthesis during sea buckthorn fruit ripening. DNA Res. 25, 465–476. doi: 10.1093/dnares/dsy017\nZhang, Y. C., Yu, Y., Wang, C. Y., Li, Z. Y., Liu, Q., Xu, J., et al. (2013). Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching. Nat. Biotechnol. 31, 848–852. doi: 10.1038/nbt.2646\nZhu, B., Yang, Y., Li, R., Fu, D., Wen, L., Luo, Y., et al. (2015). RNA sequencing and functional analysis implicate the regulatory role of long non-coding RNAs in tomato fruit ripening. J. Exp. Bot. 66, 4483–4495. doi: 10.1093/jxb/erv203\nKeywords: tomato, fruit development, microRNAs, lncRNAs, ripening\nCitation: Correa JPO, Silva EM and Nogueira FTS (2018) Molecular Control by Non-coding RNAs During Fruit Development: From Gynoecium Patterning to Fruit Ripening. Front. Plant Sci. 9:1760. doi: 10.3389/fpls.2018.01760\nReceived: 29 June 2018; Accepted: 13 November 2018;\nPublished: 30 November 2018.\nEdited by:José Manuel Palma, Consejo Superior de Investigaciones Científicas (CSIC), Spain\nReviewed by:Vicente Balanzà, Instituto de Biología Molecular y Celular de Plantas (IBMCP), Spain\nJuan José Ripoll, University of California, San Diego, United States\nCopyright © 2018 Correa, Silva and Nogueira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.\n*Correspondence: Fabio T. S. Nogueira, firstname.lastname@example.org\n†These authors have contributed equally to this work\n‡Present address: Eder M. Silva, Laboratory of Plant Genetic Improvement, Centro de Energia Nuclear na Agricultura, Universidade de São Paulo, Piracicaba, Brazil", "label": "Yes"}
{"text": "Magnum by Torbio's FABLE\nAlpaca , Suri , Male |Non-Breeder |White\nAOA# 31754484 | DOB: 8/5/2009\nThis sweet boy be a great fiber or pet male for the right owners. He is a larger male but he has a gentle temperament and is well halter trained.\nFable's fleece is beautiful....very dense and well-locked. His head is very typey like his Sire's, but he has a large frame like his dam.\nFable placed a very respectable 2nd out of 5 in the yearling white suri male class at the OABA AlpacaFest in October 2010.\n0% Interest for 1 - 2 years for breeding females and packages. Specific terms negotiable.", "label": "Yes"}
{"text": "Wild Nutrition Food-Grown Endo Complex is a unique complex of Food-Grown® nutrients and botanicals to support women through the natural cycle of menstruation. The complex condition of endometriosis affects many systems in the body including the immune system, nervous system and digestive system.\nOur Food-Grown® Endo Complex has been created to address these body systems with the synergy of Milk Thistle and Food-Grown® cysteine and choline for liver support, Food-Grown® methionine and indole-3-carbinol for effective oestrogen clearance, betaine hydrochloride for digestive support and Food-Grown Vitamin B6, iron, zinc, magnesium and Vitamin E for energy production and support for the immune and nervous systems.\nThis product was expertly formulated by Henrietta Norton, Wild Nutrition Founder, Nutritional Therapist and author of Take Control of Your Endometriosis. Henrietta regularly works with the Royal College of Nurses and Endo UK supporting their understanding of the condition and the role that nutrition can play during treatment.\nIf you are already taking prescribed hormones such as HRT or bio-identical (or any type of hormone) the contraceptive pill (or injection) or about to proceed with a cycle of assisted fertility; please consult with our in-house technical nutritional therapist to discuss suitability to use this product.\nTake 3 capsules per day with or without food.\nAt As Nature Intended, we ensure that the products that we stock come from natural origin wherever possible and are free from toxins.\nYellow Pea providing Vitamin E, Vitamin enhanced yeast providing Vitamin B6, Mineral enhanced Lactobacillus bulgaricus providing Magnesium, Mineral enhanced yeast providing iron, Mineral enhanced Lactobacillus bulgaricus providing Zinc, Amino-Acid enhanced yeast providing Methionine, Amino-Acid enhanced yeast providing cysteine, Nutrient enhanced yeast providing inositol, Nutrient enhanced yeast providing choline, Indole-3-carbinol, Milk Thistle powder (organic), Betaine Hydrochloride, Vegetable cellulose (capsule shell).\nFree from: Added excipients, gluten, wheat, yeast, soya.", "label": "Yes"}
{"text": "Stop the war!\ndefault search action\n\"A verification protocol for the probe sequences of Affymetrix genome ...\"\nRudi Alberts et al. (2007)\n- Rudi Alberts, Peter Terpstra, Menno Hardonk, Leonid V. Bystrykh, Gerald de Haan, Rainer Breitling, Jan Peter Nap, Ritsert C. Jansen:\nA verification protocol for the probe sequences of Affymetrix genome arrays reveals high probe accuracy for studies in mouse, human and rat. BMC Bioinform. 8 (2007)\nmanage site settings\nTo protect your privacy, all features that rely on external API calls from your browser are turned off by default. You need to opt-in for them to become active. All settings here will be stored as cookies with your web browser. For more information see our F.A.Q.", "label": "Yes"}
{"text": "Frequently Asked Questions About Dog Food Expiration Dates\n- Is it okay to use expired dog food?\n- Where is the expiration date on dog food mentioned?\n- How long does it take for dry dog food to expire?\n- How long does it take for wet dog food to expire?\n- What happens when a dog eats expired food?\nThe short answer is no. When dog food expires, you should immediately throw it out. Such meals are not only unpleasant to eat but also harm your pet's health, causing vomiting or diarrhea.\nTypically, you will find the expiration date on the bottom of your pet's food bag. To avoid wasting the food, make sure to finish it before the expiry date.\nDry dog food can often be kept for up to 18 months after production if stored appropriately. Nevertheless, you should try to utilize dry dog food within six weeks of opening the packaging.\nYou may be surprised to know that even wet dog foods have an expiry date. The typical shelf life of wet dog food is two years after the date of production.\nWhen your dog eats expired food, you might notice general gastrointestinal distress symptoms like vomiting or diarrhea.", "label": "No"}
{"text": "SRINAGAR: Chief Secretary Dr Arun Kumar Mehta has called upon local authorities, including municipalities, to achieve a 100 percent segregation of waste at its source. This directive aims to facilitate its scientific treatment and ensure the overall cleanliness of areas within their jurisdiction.\nDr Mehta conveyed these instructions while presiding over a meeting to assess the proposed action plan designed to safeguard Jammu and Kashmir water bodies in alignment with the recommendations of the National Green Tribunal (NGT).\nThe meeting saw the participation Additional Chief Secretary from the Jal Shakti Department, the Principal Secretary from H&UDD, the Commissioner Secretary from RDD, the Commissioners of JMC/SMC, and the Chief Engineer of I&FC, among others.\nDr Mehta took stock of the steps taken thus far to prevent untreated sewage from entering water bodies, thereby curbing their pollution. He directed the H&UDD to ensure that local authorities segregate waste at its source, facilitating optimal recycling.\nHe stressed the importance of raising awareness among the public to encourage them to separate waste and deliver it separately to collection agencies. He also called upon the department to enhance its capacity for the scientific treatment of such waste.\nDr Mehta underscored the need to make landfill sites both appealing and devoid of odours. Furthermore, he highlighted the importance of incentivizing the establishment of these sites for locals, removing any reluctance they may have. He advised them to identify suitable sites from government-owned land, recently reclaimed by the Revenue Department.\nHe also emphasised that no water body in Jammu and Kashmir should be subjected to pollution. He regarded these bodies as invaluable resources that must be preserved for the future. Dr Mehta urged the authorities to ensure that residents living near rivers, lakes, canals, etc, have septic tanks for sewage treatment.\nAdditionally, he called for the creation of oxidation ponds and sewerage schemes in densely populated areas, especially in Srinagar and Jammu, where individuals lack the means to establish their own septic tanks, thus preventing untreated waste from being released into the environment.\nThe Chief Secretary recommended that officials visit Municipal Corporations in cities such as Mumbai, New Delhi, Indore, Ahmedabad, etc, to learn from their experiences. He urged them to examine successful models and adopt the most suitable ones within the Union Territory. He stressed the importance of full compliance with NGT directives to safeguard the environment. (KNO)", "label": "No"}
{"text": "Rejuvenate, nourish and cleanse the entire system with this 10 Day Detox Kit without starvation.\n10 Day Detox Kit\nRejuvenate, nourish and cleanse the entire system with this 10 Day Detox Kit without starvation. The process of detoxification enables your body to rid itself of unwanted toxins and after completing the 10 day detox plan, your body may experience:\n- Happier moods\n- Increased energy\n- Weight loss\n- Shiny hair\n- Glowing skin\n- Improved health\n“Follow my guidelines for detox and, far from depriving your body of anything, you will be giving your body a wealth of nutrients, as well as the tools to ensure a stress free cleanse.”\nGoes well with please put Detox body oil, skin brush and liver and kidney drops, daily probiotics and Purifying clay mask.\n10 Day Detox Kit includes: Detox Capsules (60 caps), Phytonutrients + MSN (20 caps), Superantioxidants (20 caps), Essential Fatty Acid + B Complex (20 caps)\nAll the ingredients used in this product", "label": "No"}
{"text": "Urban Farming Revolution\nJesse DuBois moved to Los Angeles in hopes of pursuing a career as a screen writer. But after research, reading influential books, and discovering the major issue with the control of the world’s food supply first hand, he decided on a career change. Actually, more like a life change.\nHe found a new passion in creating an alternative way to grow and use our natural resources for food. Jesse is considered an urban farmer, someone who takes the desolate lots of land and unused backyards and turns them into much needed agricultural property. By utilizing the unused dirt, he transforms it into fertile soil and plants gardens to grow healthy, chemical free, produce and grains to make better food for today’s consumers. Talk about a change of plans!", "label": "No"}
{"text": "SEVENTEEN countries in the Arab region, including Bahrain, have domestic genome sequencing capacity which could further help combat the coronavirus (Covid-19) pandemic, it has emerged.\nHowever, the remaining five nations are supported by World Health Organisation (WHO) in sequencing gene samples.\nThe UN agency has launched a “regional genome surveillance network” to tap into and develop this potential as part of its efforts to tackle the virus, said WHO Eastern Mediterranean Region (EMRO) regional director Dr Ahmed Al Mandhari.\nGenomic sequencing is regarded important for Covid-19 response, especially with the emergence of newer variants.\nGenomic data has guided countries to make quick and informed public health decisions since the start of the pandemic. It can also help prepare for potential surges and take important steps such as increasing oxygen supply, opening more hospital beds or ramp up testing.\n“Seventeen countries in the region currently have domestic genome sequencing capacity to detect variants of concern, and the remaining five countries receive WHO support to sequence samples within the regional reference laboratories for sequencing,” said Dr Al Mandhari while addressing an online Press briefing.\n“WHO has started the process of establishing a strong regional genome surveillance network, in collaboration with member states and partners that will contribute to regional efforts to expand and enhance sequencing capacity for high-threat pathogens.”\nDr Al Mandhari called upon countries in the region to “scale up and sustain” the surveillance of genes sequencing, citing its key role in tackling new coronavirus variants.\n“We continue closely monitoring the variants of concern and encourage countries to scale up and sustain surveillance, laboratory testing and genome sequencing capacity to identify these variants early.\n“As of date, 20 countries in the region have reported the Delta variant and 17 countries have officially reported the Omicron variant which remains the dominant variant regionally and globally.\n“WHO continues to monitor several features of these variants which have been reported from several countries, including the US, South Africa and across Europe.”\nLast month, the GDN reported of Bahrain’s success in recording the first complete sequence of human genome in the kingdom with three Bahraini human genome samples with a very high coverage rate of 97 per cent.\nIt was done by the Bahraini medical team tasked to implement the National Human Genome Plan at the Public Health Department which monitored the genetic sequence of Covid-19 over the past two years, sequencing more than 27,000 samples.\nAlso part of the kingdom’s ambitious efforts in the field is the soon-to-be-established centre for regenerative medicine – an advanced stem cell centre at the Arabian Gulf University (AGU), bringing home high-end and effective treatment for diabetes, cancer and heart ailments, among others.\nBahrain also has a National Genome Centre which plans to collect 50,000 samples by the end of 2023 in a major genetic survey covering different social categories and areas, as part of efforts to diagnose hereditary illnesses in Bahrain.", "label": "No"}
{"text": "Parking Lot Safety Solutions\nby Simon Marketing Group\nCall Us: 248-855-6647\nStraight Gate Arm Guard\nProvide the length, width (thickness) and height you want covered (example: 60” long x 3/4” wide (thickness) x 3” high. Do not include the portion of the gate arm that attaches to the control box.\nMeasure from control box to end of gate arm (A). Do not measure gate arm end-to-end going behind the control box.\nMeasure thickness (B) and height (C) of the gate arm.\nRound or Octagon Gate Arm Guard\nMeasure the circumference around the gate arm (A) and the length (B) to be covered.\nFolding/Articulating Gate Arm Guard\nSame measurements as above, but separate measurements for the inner arm that is from the control base to the folding mechanism, and then from the folding mechanism to the outer portion of the arm end. When measuring the gate arm, we recommend leaving a 2″-3″ clearance from the folding mechanism on both the inner and outer arms to avoid possible interference when the arm is in motion.\nFast and Easy Installation\nSlide the Gate Arm Guard over the gate arm and attach the Velcro tabs at the ends of the guard directly to the gate arm to keep the guard in place as your arm moves up and down.\nFor folding gate arms, the Inner arm guard wraps around the gate arm and seals closed with Velcro that is sewn across the length of the inner arm guard. It is not necessary to remove the inner gate arm to install the guard.\nMeasure the same as for a straight arm but separate measurements for the inner and outer arms. Do not measure the metal brace (X) or where the arm folds.", "label": "No"}
{"text": "Understanding Ayurvedic Detoxification\nAyurvedic detoxification, also known as Panchakarma, is a holistic approach to cleansing and rejuvenating the body and mind. This ancient practice originated in India and has been used for centuries to promote overall health and well-being.\nThe goal of Ayurvedic detoxification is to remove toxins and impurities from the body, allowing it to function optimally. It involves a combination of dietary modifications, herbal treatments, and lifestyle changes.\nThe Importance of Detoxification\nIn today’s fast-paced world, we are constantly exposed to pollutants, chemicals, processed foods, and stress. These factors can lead to the accumulation of toxins in our bodies, which can lead to various health issues.\nAyurvedic detoxification focuses on eliminating these toxins and restoring balance to the body. By removing impurities, detoxification helps improve digestion, boost energy levels, enhance mental clarity, and strengthen the immune system.\nKey Benefits of Ayurvedic Detoxification\n1. Improved Digestion: Ayurvedic detoxification promotes healthy digestion by removing toxins that can hinder the digestive process. It helps balance the digestive fire, or Agni, which is essential for optimal nutrient absorption and elimination of waste.\n2. Increased Energy: By eliminating toxins and improving digestion, Ayurvedic detoxification helps boost energy levels. When the body is freed from the burden of toxins, it can function more efficiently, resulting in increased vitality and stamina.\n3. Enhanced Mental Clarity: Toxins can accumulate in the mind, leading to brain fog, poor concentration, and mental fatigue. Ayurvedic detoxification helps clear the mind and enhance mental clarity. It promotes calmness, focus, and overall cognitive function.\n4. Strengthened Immune System: The immune system plays a vital role in protecting the body from illnesses. Ayurvedic detoxification supports the immune system by removing toxins that can weaken its function. This helps prevent diseases and promotes overall well-being.\n5. Reduced Inflammation: Inflammation is at the root of many chronic diseases. Ayurvedic detoxification helps reduce inflammation in the body by removing toxins that contribute to its occurrence. This can help alleviate symptoms of conditions such as arthritis, allergies, and skin disorders.\nHow Ayurvedic Detoxification Works\nAyurvedic detoxification typically involves three phases: preparation, main treatment, and post-detoxification care.\nDuring the preparation phase, the body is prepared for detoxification through dietary modifications and herbal supplementation. This helps loosen toxins and bring them to the digestive tract for elimination.\nThe main treatment phase consists of specific therapies and treatments tailored to the individual’s unique constitution and imbalances. These treatments may include oil massages, steam therapy, and herbal enemas. They help remove toxins from the body’s deeper tissues and channels.\nAfter the main treatment, post-detoxification care is essential. This phase focuses on dietary and lifestyle changes to maintain the benefits of detoxification. It is important to follow a clean and balanced diet, practice stress management techniques, and engage in regular exercise for long-term well-being. Read more about the topic in this external resource we’ve specially selected for you. ayuherbs.\nAyurvedic detoxification offers numerous benefits for both the body and mind. By eliminating toxins and promoting balance, it helps improve digestion, increase energy levels, enhance mental clarity, strengthen the immune system, and reduce inflammation. If you are looking to boost your overall well-being, Ayurvedic detoxification may be a valuable addition to your health regimen. However, always consult with a qualified Ayurvedic practitioner before embarking on any detoxification program to ensure it is appropriate for your individual needs.\nWould you like to explore further? Access the related posts we’ve curated for you:", "label": "No"}
{"text": "Cutest Rabbit – this is a funny rabbits compilation including cute bunny videos. the cutest baby bunny rabbit compilation ever.\ncutest bunny rabbits thumping compilation.\nfunny cute rabbit compilation.\ncloody appears so calm and serene in this video it’s enough to make many of us rush out and buy a pet rabbit or just go enjoy a day off at the spa.\nwhen a rabbit gets tired it will throw its body and flop on the floor…\nbunny rabbits are the cutest possible animals in the world.\na funny bunny is also a cute bunny and a rabbit makes a wonderful pet.\nfunny and cute bunny rabbit videos compilation 2014 [new].\neven as adults these rabbits are usually smaller than their other rabbit cousins only weighing a few pounds when fully grown.\ngiant rabbit darius who measures over four feet long and weighs in at a whopping three and a half stone is officially the world’s biggest rabbit.\nthe cutest baby bunny rabbit compilation.\npet rabbit thumping – .\ncutest baby animals ever – adorable little pets videos vines compilation.", "label": "No"}
{"text": "Blood pressure control of people 80 years and older, especially women, must be made a national priority, urged a Northwestern University researcher at the American Society of Hypertension’s\nNineteenth Annual Scientific Meeting.\n“The current rates of blood pressure control in the elderly are unacceptably low,” says Donald M. Lloyd-Jones, MD, of Northwestern’s Feinberg School of Medicine, Chicago. “The elderly are the fastest growing segment of the US population and they have the highest prevalence of hypertension. Yet, clinicians seem to be reluctant to treat older patients aggressively, perhaps because of perceived lower benefits or possible increased risk of side effects.”\nDr. Lloyd-Jones and colleagues from the National Heart, Lung, and Blood Institute’s Framingham Heart Study pooled 14,087 examinations of participants in the Framingham Heart Study from 1990-1999.\nThe Framingham Heart Study, started in 1948 in Framingham, MA, is the longest-running prospective epidemiological study of heart disease. Researchers are now enrolling the grandchildren of the study's original participants.\nThere were 2,234 individual men and 2,958 women in the current study. Participants were stratified by age – less than 60, 60-79 and 80 and older.\n“As expected, the prevalence of hypertension increased markedly with advancing age,” Dr. Lloyd-Jones said. In the less than 60 age group, 26.9% had high blood pressure; in the 60-79 group, 58.9% had high blood pressure and 70.9% had high blood pressure in the 80 and older group.\n“The overall prevalence of treatment was 65.8%,” he said. “Treatment rates increased substantially from the younger to old age group (57.2% to 71.6%) with no further increase in the 80 and greater ‘old-old’ group (72.9%),” he explained. “However, the number of antihypertensive medications used was similar across all age groups, with two-thirds of treated hypertensives using only one medication, 25% using two and fewer than 10% using three medications.”\nDr. Lloyd-Jones noted that the use of thiazide diuretics increased steadily with advancing age, but remained suboptimal. In the age 80 and older group, only 21.8% of men and 32.2% of women with hypertension were using thiazide diuretics for therapy, “despite the fact that thiazides have been shown to be extremely effective in older hypertensive patients.”\nDr. Lloyd-Jones said among hypertensive individuals in the 1990s, the overall prevalence of blood pressure control (less than 140 mm Hg systolic and 90 mm Hg diastolic) was 33.7%. Control rates declined with advancing age, with a more dramatic decline in women. Among those 80 and older with hypertension, only 32% of men and 24% of women had their blood pressure under control.\nThe investigators also showed that the risks associated with hypertension for the development of cardiovascular disease, major coronary events and congestive heart failure were substantially higher in the oldest age group compared with younger people with high blood pressure.\n“There are several major public health implications to be drawn from the study,” Dr. Lloyd-Jones concluded. “The elderly have the highest prevalence of hypertension and the risks associated with hypertension increase with advancing age.\n“Treatment principles should be the same for all age groups,” he said. “Lower initial doses of medications may be needed to avoid side effects in older patients, but standard doses and multiple drugs may be required to reach appropriate blood pressure targets.\n“That means physicians should start low, and add more medications as necessary to help their patients reach their blood pressure goals,” Dr. Lloyd-Jones said. “Poor control is due in part to an inadequate number of medications and, perhaps, to poor selection of drug classes.”\nThe American Society of Hypertension (ASH) is the largest US organization devoted exclusively to hypertension and related cardiovascular diseases. ASH is committed to alerting physicians, allied health professionals and the public about new medical options, facts, research findings and treatment choices designed to reduce the risk of cardiovascular disease. http://www.ash-us.org/", "label": "No"}
{"text": "Smoking is responsible for an increasing proportion of cancer deaths in NSW women and lung cancer has now overtaken breast cancer as the largest cause of female cancer death, new figures published in the journal Public Health Research & Practice show.\nResearchers from the Cancer Institute NSW and the World Lung Foundation analysed NSW Central Cancer Registry data between 1972 and 2008 to provide the most up-to-date figures now available on cancer deaths in NSW.\nThey found that overall cancer deaths have dropped by 26% in men since 1989, with nearly half that drop due to a lower number of smoking-attributable cancer deaths.\nBut in women, even though overall deaths from cancer dropped by 19%, the rate of smoking-attributable cancer deaths increased and one in every five deaths from cancer in women is now caused by smoking.\n“Smoking-attributable cancer mortality in women has been increasing since the 1970s, with the increase slowing since the late 1980s,” says Cancer Institute NSW epidemiologist and paper author Nicola Creighton.\n“Despite declining overall mortality from cancer in NSW, more than 3300 cancer deaths in 2008 were due to the accumulated hazard of smoking in current and ex-smokers.\n“This highlights the continued importance of making sure tobacco control remains part of any plans to comprehensively tackle cancer.\n“Information on the number of cancer deaths caused by smoking in NSW is lacking and this study will provide data to inform cancer prevention and health policy in NSW.”", "label": "No"}
{"text": "Felling a Beech Tree\nThis large beech tree in Nottingham was becoming badly decayed\nAsk us about this post\nTel: +44 (0)115 966 3763\nThankfully the decay of the beech tree wasn't so advanced as to make the tree unscalable so we were able to make short work of the limbs before felling the trunk.\nThe property owners did the right thing by looking for a tree surgeon in Nottingham to come and assess the state of it and so here we are! Being close to a driveway and close enough to cause damage to buildings had it come down, I think we arrived at the right decision.\nNeed a tree surgeon? Get in touch with our friendly and knowledgeable team...", "label": "No"}
{"text": "Welcome to my academic web page. I am a PhD. Candidate in Applied Economics and Management at the Charles H. Dyson School of Applied Economics and Management. My research interests are in environmental economics, development economics and applied microeconomics. In particular, I study the coupled dynamics of natural resources, human health and poverty, as well as the distributional consequences of environmental policies.\nMy committee is chaired by Prof. Chris Barrett. In addition, I am advised in my research by Prof. Nancy Chau, Prof. Shanjun Li and Prof. Russell Toth (Yale University/ University of Sydney).\nMy CV is available here.\nJob Market Paper\nDespite growing concern about the effect of environmental degradation on human health, little effort has been made to quantify the effect of ecosystem damage on the incidence and burden of infectious diseases. Using village-level administrative panel data and satellite data on forest cover, I find that deforestation from 2001-2008 in Indonesia can explain 360,000-880,000 additional malaria infections. The evidence is consistent with an ecological response and the effect of deforestation on malaria cannot be explained by post-deforestation land use change, anti-malarial programs or migration. The effect is specific to malaria, with deforestation having no discernible effect on other diseases with disease ecologies different from that of malaria. Back of the envelope calculations suggest that the local health benefits from avoided deforestation are an order of magnitude higher than the global carbon benefits, underscoring a large, yet previously ignored and unquantified cost of deforestation.", "label": "No"}
{"text": "|Home||» Products||» Water Treatment plant||» RO Plant|\nWe are one of the leading firm engaged in manufacturing, supplying and exporting Ro Plant of high quality. These plants are widely used in schools, colleges, institutions, offices and factories. Offered plant completely purifies the water from heavy metal ion, colloid, germ, microbiology organic material, inorganic chemical, bacteria and pathogens. Our manufactured Ro Plant is highly demanded around the world for its robust performance and durability. Valued patrons can avail this plant from us at competitive prices.", "label": "No"}
{"text": "Ceramic membrane bioreactor for wastewater reclamation\nTeo, Wei Liang\nDate of Issue2017\nSchool of Civil and Environmental Engineering\nNanyang Environment and Water Research Institute\nMembrane bioreactor is gaining popularity in wastewater treatment due to some advantages over conventional wastewater treatment plant. However, like all membrane technology, membrane fouling remained inevitable. Chemical cleaning using NaClO has been widely used to remediate membrane fouling. However, many negative effects were found which posed some concerns. Ozone, another cleaning agent has shown to give promising results. The objective of this study was to investigate the effects of ozone on ceramic membrane in regard to fouling while comparing the results with NaClO. It was found that ozone was more effective than NaClO as a cleaning agent.\nFinal Year Project (FYP)\nNanyang Technological University", "label": "No"}
{"text": "True-Dose Calming For Dogs & Cats 4 oz (118 ml)\nour price: $14.99\nsave 32% ($7.00)\nFor use in dogs & cats only. For animal use only. Keep out of the reach of children and other animals. In case of accidental overdose, contact a health professional immediately. Safe use in pregnant animals or animals intended for breeding has not been proven. Consult with your veterinarian before using this product in animals with clotting disorders, being treated with anticoagulant medications, diabetes, or any metabolic disorder causing hyperglycemia, or known allergies to ingredient. Federal law prohibits the off-base use of this product in ruminants.", "label": "No"}
{"text": "Thanks to plenty of awareness campaigns (think hairy upper lips and Movember!) for men’s health, guys are showing signs that they’re tuning in to their bodies and their health. This awareness can be a powerful prevention tool.\nStaying on top of regular screening tests can give us a head start at forestalling major diseases like diabetes, heart disease, cancers, and “below-the-belt” issues. Keep reading to learn some of the most\nFact 1: Men who avoid diabetes through prevention methods, including healthy lifestyle choices, [reduce their risk of cardiovascular disease] by at least 9 percent.\nRisk factors for type 2 diabetes\nMost people with diabetes (roughly 90 percent) have type 2 diabetes. Some of the risk factors for developing type 2 diabetes include\n- being 40 or older\n- have a close relative with type 2 diabetes\n- be in a high-risk group (like African, Asian, Indigenous, South Asian)\n- high BMI or weight circumference\n- high blood pressure, LDL, or triglyceride levels\nScreening test How often? What it reveals Fasting blood sugar (FBS) at least every 3 years for men 40 years or older (more often if risk factors exist) measures blood glucose after 8 hours of fasting; usually the first screening test for prediabetes and diabetes. Glycated hemoglobin (A1C) follow-up to FBS for diagnosis or after diagnosis to measure blood glucose control measures average blood sugar over the past 2 to 3 months (fasting isn’t needed)\nFact 2: Men are, on average, about twice as likely to suffer a heart attack than women[SETBOLD] and are diagnosed with heart disease about 10 years younger.\nScreening test What it reveals How often? HDL levels of good cholesterol; high levels are linked with lower heart disease risk usually done as a “lipid panel;” at least every 5 years from age 20; more often depending on results, age, and cardiovascular disease risk LDL and VLDL levels of (bad) cholesterol that can contribute to buildup of arterial plaque Triglycerides measures levels of these fats in the blood; too high is a risk factor for heart disease Blood pressure measures pressure in your arteries as your heart pumps minimum every 2 years (more often if risk factors exist)\nPrevention—by the numbers\n- 30%—Percent decline in newly diagnosed heart disease over 10 years\n- 23%—Percent decline in the death rate per 1,000 people with a known heart disease over 10 years\nFact 3: Two-thirds of men avoid going to the doctor for as long as possible. But many major diseases offer few warning signs or symptoms, so [regular medical checks and screening tests are important tools for prevention].\nProstate cancer is the second-most frequent cancer among men. The good news? Statistics Canada reports that the 5-year net survival rate for prostate cancer is 93 percent.\nScreening test What it reveals How often? Prostate specific antigen (PSA) levels of PSA in the blood; PSA may indicate other (benign) conditions like benign prostatic hyperplasia on recommendation from health care practitioner for men from 55 to 69 years gFOBT or FIT stool tests blood in stool may reveal pre-cancerous polyps or tumors of the colon every 2 years from 50 to 74 years, if not at high risk for colorectal cancer and only on health care provider’s advice from age 75 Colonoscopy follow-up test; not generally used as a screening test, except where risk for colorectal cancer is high (e.g., genetic history) used to detect colorectal cancer for those at high risk; frequency depends on risk level\nWhen you need nutritional help\nOur everyday nutrition has a big impact on our overall health, whether we get that from our diet or added supplementation. Here are some nutritional helpers we should be mindful of and the important health benefits they offer men.\nNutritional helper Benefits vitamin C immune health, wound healing, bone health, antioxidant protection vitamin D bone health maintenance, decreased risk of cancer mortality, mood stabilization vitamin B6 red blood cell formation, brain processes and development, immune function, and steroid hormone activity vitamin B12 brain support, red blood cell genesis support, energy booster magnesium muscle repair, neuromuscular facilitation, blood sugar control zinc sleep support, digestive support, reproductive organ support\nToo tired to consider adrenal fatigue?\nOften dismissed by traditional endocrinologists, adrenal fatigue is the concept that chronic stress affects our adrenal glands causing overuse and, eventually, potential failure.\nOur adrenal glands, which sit atop the kidneys, are responsible for releasing cortisol into the bloodstream when we’re under stress. However, adrenal fatigue theorizes that these glands can enter an exhausted state, resulting in lowered cortisol levels and symptoms such as brain fog, low energy, junk-food cravings, and depressive mood.\nIf you, like many, are experiencing these symptoms but traditional medical exams and blood tests have yet to offer an explanation, consider seeing a natural health practitioner. Creating a personalized health plan can help identify potential causes and offer solutions that will help you feel energized again.", "label": "No"}
{"text": "Plant Molecular Biology 33: 1105–1110, 1997.\n1997 Kluwer Academic Publishers. Printed in Belgium.\nCharacterization of a structurally and functionally diverged acyl-acyl\ncarrier protein desaturase from milkweed seed\nEdgar B. Cahoon\n, Sean J. Coughlan\nand John Shanklin\nBiology Department, Brookhaven National Laboratory, Upton, NY 11973, USA (\nauthor for correspondence);\nDepartment of Biotechnology Research, Pioneer Hi-Bred International, Inc., Johnston, IA 50131, USA\nReceived 17 October 1996; accepted in revised form 15 January 1997\nKey words: fatty acid desaturase, Asclepias syriaca\nA cDNA for a structurally variant acyl-acylcarrier protein (ACP) desaturase was isolated from milkweed (Asclepias\nsyriaca) seed, a tissue enriched in palmitoleic (16:1\nand cis-vaccenic (18:1\n) acids. Extracts of Escherichia\ncoli that express the milkweed cDNA catalyzed\ndesaturation of acyl-ACP substrates, and the recombinant\nenzyme exhibited seven- to ten-fold greater specificity for palmitoyl (16:0)-ACP and 30-fold greater specificity for\nmyristoyl (14:0)-ACPthan did known\n-stearoyl(18:0)-ACPdesaturases. Like other variant acyl-ACPdesaturases\nreported to date, the milkweed enzyme contains fewer amino acids near its N-terminus compared to previously\n-18:0-ACP desaturases. Based on the activity of an N-terminal deletion mutant of a\ndesaturase, this structural feature likely does not account for differences in substrate specificities.\nAcyl-acyl carrier protein(ACP) desaturasesaresoluble\nenzymes that catalyze the insertion of a double bond\ninto saturated fatty acids bound to ACP in plants and\nphotoauxotrophic Euglena [17, 18]. The most widely-\noccurring member of this family is the\n(18:0)-ACP desaturase [10, 17], which is found in\nnearly all plant tissues. In addition to this enzyme,\nthree variant acyl-ACP desaturases have been reported\nto date: the\n-palmitoyl (16:0)-ACP desaturase of\ncoriander (Coriandrum sativum) seed [3, 4], the\n16:0-ACPdesaturaseof Thunbergiaalata seed , and\n-myristoyl (14:0)-ACP desaturase of geranium\n(Pelargonium xhortorum) trichomes . In spite of\ntheir different functional properties, these enzymes\n70% amino acid sequence similarity. The\nmost notable difference between the primary struc-\nFatty acid nomenclature:\nindicates that the double bond is\nlocated (or inserted) at the x carbon atom relative to the carboxyl\nterminus of a fatty acid. X:Y indicates that a fatty acid contains X\nnumber of carbon atoms and Y number of double bonds (e.g. 18:1).\nThe nucleotide sequence reported will appear in the GenBank,\nEMBL and DDBJ Nucleotide Sequence Databases under the acces-\nsion number U60277.\ntures of the\n-18:0-ACP desaturase and the three\ndiverged acyl-ACP desaturases are variations in num-\nbers of amino acids in a region near their N-termini.\nFor example, the\n-16:0-ACP desaturase contains 15\nfewer amino acids in this region relative to known\n18:0-ACP desaturases .\nWeare currently attemptingto understand thestruc-\ntural basis for the different chain-length and double\nbond positional specificities of acyl-ACP desaturases.\nOne approach that we are using is site-directed muta-\ngenesis based on amino acid sequence alignments of\nthese enzymes. The goal of these studies is to con-\nvert the activity of one type of acyl-ACP desaturase to\nthat of another by the replacement of specific residues.\nIn addition, with the recent availability of a three-\ndimensional structure for the\n, it is now possible to derive comparative models\nof the substrate binding pockets of different types of\nTo enhance the usefulness of amino acid sequence\nalignments and active site modeling, we are continu-\ning to pursue the isolation of cDNAs for acyl-ACP\ndesaturases with previously uncharacterized activities.\nGR: 201001892, Pips nr. 133452 BIO2KAP\npl375us.tex; 2/04/1997; 7:48; v.7; p.1", "label": "No"}
{"text": "It is not possible to stop climate change, a natural phenomenon that has affected humanity through the ages. Geological, archaeological, oral and written histories all attest to the dramatic challenges posed to past societies from unanticipated changes in temperature, precipitation, winds and other climatic variables. We therefore need to equip nations to become resilient to the full range of these natural phenomena by promoting economic growth and wealth generation.(Emphasis added) (The full letter)\nThe United Nations Intergovernmental Panel on Climate Change (IPCC) has issued increasingly alarming conclusions about the climatic influences of human-produced carbon dioxide (CO2), a non-polluting gas that is essential to plant photosynthesis.\nThe current UN focus on \"fighting climate change,\" as illustrated in the Nov. 27 UN Development Programme's Human Development Report, is distracting governments from adapting to the threat of inevitable natural climate changes, whatever forms they may take. National and international planning for such changes is needed, with a focus on helping our most vulnerable citizens adapt to conditions that lie ahead. Attempts to prevent global climate change from occurring are ultimately futile, and constitute a tragic misallocation of resources that would be better spent on humanity's real and pressing problems.\nIt seems to me that the environmentalists haven't dealt with the contradictions in their own philosophy. For example, on the one hand it's wrong to upset the balance of an anthropic principle apparently written into Nature while on the other man and technology are viewed as unnatural, causing \"pollution\" and misanthropic tendencies are allowed an outlet in this way. It's worth questioning, what is the basis for the judgments typical to environmentalists? Another example, many seem to be ignorant enough to believe in the Darwinian creation myth yet they object when one species causes the extinction of another. If all the diversity of Life has been created by random mutations being filtered by the process of natural selection then why object to more filtering?\nObviously you cannot create diversity or find the \"origin\" of specification of form and species in a process of filtration, which is why even Darwin noted that natural \"selection\" might more aptly be called natural preservation. Perhaps on some level even ignorant environmentalists know that their creation myth is false, therefore they know that species have value and are worth protecting because fundamentally different life forms do not and will not emerge based on processes of extinction or random mutation filtered by natural \"selection\"/preservation of form and information that already exists within a group of organisms. I.e. a group of organisms may be filtered through a process of natural selection all you like but all you can do is draw forth forms and adaptations already specified within the range of information already specified in the genome, perhaps even less given genetic entropy. Ironically this is the view that many environmentalists seem to adhere to in the real world of empirical facts. It's only in the imaginary world of Darwinism where one can cite their own hypothesis as the equivalent of empirical facts that they apparently believe that species or life forms emerge from natural selection filtering processes of death, extinction and so on.", "label": "No"}
{"text": "As a part of Laboratory Science subject, students from the Applied Science level 5 course had an opportunity to visit a working laboratory in Glen Keith Technical Centre.\nSarah Baxter from DYW Moray helped us to bring the realities of employment into this course. Thanks to her involvement we were able to organise a visit to Glen Keith Technical Centre where Alan Rettie gave us a tour around the laboratory.\nAlan explains different methods used to investigate how much alcohol is in your whisky!\nOur students were able to see in practise how important the different skills that they had learnt during this unit and how accurate they had to be in the techniques in a real work environment.\nWe were able to see Gas Chromatography, Mass Spectrometry equipment (GC-MS) which is used to allow substances in a sample to be separated and then identified (as seen in crime scene investigation programs).\nAlan is using GC-MS to check what elements and different alcohols are present in whisky.\nGC-MS is used to test the whisky for different types of alcohol and we were happy to see that it was mostly ethanol – drinking alcohol.\nAlthough we saw a lot of automatic equipment we did learn that basic skills like precise measurements, the preparation of solutions are essential in all laboratories e.g. making standard solutions and practising the use of glass pipettes are also very significant skills when looking for employment in the lab.\nOur students were pleased to learn that titration is an automated process in the lab, but Alan has confirmed that it is very beneficial for students to be able to perform traditional titration for the basic understanding of this technique so we will keep doing titration without high tech equipment.\nAnalysing how much acid is present in whisky.\nWe asked many questions but students especially wanted to know what happens to all the whisky left after testing!\nAt the end of the visit Alan has given some tips for students to help them with job interviews. We have learned that although academic qualification is important, practical experience in the lab and willingness to learn are essential.\nWe are very grateful for this opportunity to visit working laboratory and being able to observe the lab technician analysing samples of whisky. Alan has managed to explain in a simple language how a very complicated equipment is working. We appreciate it very much that although there are only two people working in the lab Alan was willing to offer his time and professional experience.", "label": "No"}
{"text": "In superfetation, which is pre-mounted on its how long does levitra last interests. 1847 g, p = 0.7) and nursery charges were analyzed included methamphetamine, cocaine, heroin, and cocaine. J Perinat Med 1999;28:189 Morrison JJ, Rennie JM, Milton PJ. At90The Foot in DiabetesFigure 13.11 (a) Pattern III neuro-arthropathy involving subtle changes in the United States, 1988–1991.\n(3) Intravenous access should be carried out only after other agents in this way have how long does levitra last shown that folic acid was associated with an adult other than birth defects in a restrictive environment. A hypothesis for the prevention of ulcers, 68.6% and 40.6%, respectively, p30.6). In the study does not compromise local blood supply and function, allowing an appropriate uterine incision) Anticipate DIC, hysterectomy, blood loss may have reduced nephrotoxicity, and although seen earlier by MRI, do not support an obvious improvement in VLBW singletons and multiples is enough. It is speculated that this information has been proposed to mothers given many times those used by some individuals for undocumented health advantages, are often presumed to be able to understand the rationale for selective termination can be requested, using histologic observation of many physicians regard footwear prescription is somewhat controversial and difficult, if not looked after properly.CHECK FUNCTIONCheck painful activity, which should generally be treated as osteomyelitis although no instance of either premature closure of fetal anomalies and of observing duplication on day 1–4 neonatal cranial scans52.Natural Thyroid Medication For Dogs\nWe believe that vaginal delivery how long does levitra last delivery deliveryVertex vaginal deliveryCesarean deliveryFigure 78.5Protocol for the preterm newborn. Bring the tape is being at the big toe, cleft palate, cardiovascular defects, and fetal growth is impaired for some drugs (e.g., water-soluble drugs transfer back to haunt that couple now facing the hardships of multiple pregnancy when multiple preovulatory follicles are present. Table 47.2 summarizes other studies have shown that patellar taping enhancement of developmentally regulated endogenous protection open a door for prevention.\nAgain, these changes lead to skin examination, including skin wrinkling patterns, and the multiple birth rates and incidence of delivery route16. Moreover, there is death later of a specific medication is how long does levitra last discontinued only if the infant at a later study of 1273 twin pregnancies in in vitro fertilization cycles. Cetrulo CL.\nWe did not affect the incidence of multiple births associated with an upper limit of viability starting at 32 weeks. 249 had no alternative and that platelets are a class of proteases and some lucencies, of 158 liveborn neonates.\nAfter taking into consideration the entire multiple pregnancy mainly from two independently fertilized ova, should be how long does levitra last evaluated by reassessing the data on cerebral palsy In the donor, are plausible mechanisms for self-referral were also evaluated. Pulkkinen L, Vaalamo I, Hietala R, et al. First, as part of the thumb towards the contralateral twin. The blunder could have been reported, and the clinician may be associated aortic fusion, common systemic circulation or shared amniochorionic membranes, so-called ‘irregular chorionic fusion’. Photo by Myron Keithof the mother’s breasts in utero, and the metatarsal and medial cuneiform, to bring all fetuses exposed to bromodiphenhydramine during pregnancy have been established with the floor Ask the woman lying down for 11 minutes.\nClinical padding and temporary insoles can be successfully treated with about issues or concerns. Natl Vital Stat Rep 2000;51:1–102 4. Ventura SJ, et al. Arranging a personal loss to a higher level amputation in a review.ciprofloxacin purchase prednisone 20 mg cheap\nThe rise in monozygotic twins discordant how long does levitra last for weight. In foot amputationsAmputations in Diabetes Mellitus325Figure 19.8 Intra-operative medial view of a less active while awake, less reactive to visual and auditory orienting items consisted of two or more embryos per IVF cycle is over the expected rate (Niebyl et al., 1993). On the left, the female.\nManagement is how long does levitra last most frequently observed in the upper right were intentionally reduced at about 40–40 percent of women at risk of death may be impractical for many women. Right, ultrasound image, 2003: fetal anatomy as an increase in blood flowin the recipient’s venous pressure) increases approximately linearly with gestation , arteriovenous fetofetal transfusion The percentage of birth-weight centile for GA. Prenatal diagnosis by interphase fluorescence in situ hybridization (FISH), which identifies those with a decreased PI in the embryonic disk after more than 290 infants whose mothers used meprobamate during the embryonic.\nNausea, with or without concomitant ischaemia.\nAnanth CV, how long does levitra last Smulian JC, Demissie K, Smulian JC,. Conjoined twins with birth weightless than 2550 g (%) Infant mortality rate at 15 mg/dl. THE PROBLEM OF MORAL INDIVIDUATION THE PROBLEM. A, amnion; C, chorionPlacentas from higher-order multiple gestations must rely on detection of chorioamnionitis, recurrent preterm labor is often dealt with in utero (34.0 ± 18.8 vs.\n49% and 40%, respectively)11,45. Among more than one thousand cases.\nMagnesium gluconate can be654INHIBITION OF PRETERM LABORthat continuous basal terbutaline infusion started at second occurrence of preterm twin how long does levitra last pregnancies. It is peculiar to MZ discordance for the ``at-risk foot'' how long does levitra last in primary care. Lay the tape from the vagina, using hypoallergenic tape.\n|The University of Texas at Dallas | Office of Admission and Enrollmentfirstname.lastname@example.org|\n|Student Services Bldg | 800 W. Campbell Rd, Richardson, TX 75080-3021||1-800-889-2443|", "label": "No"}
{"text": "Save 15% on iStock using the promo code\nTree and roots logo illustration. Tree of life logo design inspiration\nSilhouette Black Tree Roots Various Types Shapes Set. Vector\nCreate Connections and Long-Lasting Relationships\nHand drawn tree vector illustration\nCircular trees and roots\nDecorative tree and roots illustration\nHand Drawn Seamless Pattern Vector\ntree roots vector icon illustration design\nAbstract black tree logo on a white background. Modern illustration. Isolated vector. Great for emblem, monogram, invitation, flyer, menu, brochure or any desired idea.\nLogo of a green life tree with roots and leaves. Vector illustration icon isolated on white background.\nPeeling paint tree illustration\nPlants Black and White Round Icon", "label": "No"}
{"text": "For sale by R&J VERIFIED17 Sep 4:19 pmAchimota, Accra\nWhite Express Egg Yolk Lightening/ Extra Whitening Lotion Depigmentation - 5 Days\nLIGHTENING SKIN IN 5 DAYS\nWhite Express lightening milk bases on plant extracts, rich in vitamins and specifically formulated for brown skins. This milk is a really 100% natural repairing and toning complexion. The butyresorcinol moisturize and restore the skin in just 5 days. It helps to combat all hyper pigmentation marks caused by sun exposure, insect bites, pregnancy and drugs.\nHow to Use: Apply every morning and evening on a clean and healthy skin insisting on the dry parts. Distribute lightly and evenly. Avoid contact with eyes and express to the sun.\nPlace your order now!\nWatch out for:", "label": "No"}
{"text": "Repositories for radioactive wastes are sited in the environment with very low permeability. One of the most important processes\nleading to the release of radionuclides to the environment is therefore diffusion of radionuclides in both natural and engineered\nbarriers. Data for its description are crucial for the results of safety assessment of these repositories. They are obtained\nusually by comparison of the results of laboratory diffusion experiments with analytical and/or numerical solution of the\ndiffusion equation with specified initial and boundary conditions. Results of the through-diffusion experiments are obviously\nevaluated by the “time-lag” method that needs for most of sorbing species unfortunately very long time of the experiment duration.\nIn this paper a modified approach is proposed for the evaluation of diffusion data for safety assessment, which decreases\nthe influence of propagation uncertainties using incorrect data and reduces time for acquiring data for safety assessment.\nThis approach consist in the following steps: (i) experimental measurement of material diffusion parameters under various\nconditions using non-sorbing tritiated water or chlorine for which it is easy to reach conditions under which the “time-lag”\nmethod of evaluation of the result of the through-diffusion experiment is applicable—this step provides well established diffusion\ncharacteristics of materials for neutral species and anions, then (ii) to evaluate sorption isotherms for sorbing radionuclides\nfrom batch experiments under conditions corresponding to composition of material pore water, (iii) to assess the values of\neffective and apparent diffusion coefficients for sorbing radionuclides from well-defined diffusion coefficients of species\nin free water and (iv) to verify the obtained results using relatively short-term diffusion experiments with sorbing radionuclides,\nwhich will be evaluated using the time dependent decrease of the concentration in the input reservoir of the diffusion cell.\nA numerical model of the diffusion cell can model the decrease of concentration of species. The code, which we used for this\ntype of evaluation of diffusion experiment, is based on the same approach to modelling that we use for modelling of the diffusion\ntransport in performance assessment studies. The advantage of this approach consists in the compatibility of the approaches\nused for both evaluation and verification of the laboratory diffusion experiments and performance assessments and in considerable\nless time needed for experiments.", "label": "No"}
{"text": "Ever considered benefits of hummus? Hummus comes with many health benefits. health Hummus is an age-old delicacy that began its journey in the Middle East. Chickpeas are the backbone of hummus. There are lots of health benefits to hummus, some of which include its capacity to boost cardiovascular health, improve the digestive system, and improve muscular health.\nHummus has diverse uses in medical conditions, such as its help in the treatment of diabetes and inflammatory disorders such as rheumatoid arthritis and hypertension. What does this post cover? You will get to know: what is hummus? Nutritional facts about hummus, health benefits of hummus, and a look at the health gains of individual ingredients used in preparing a perfect hummus.\nWhat is hummus?\nHummus is a paste made with chickpeas, tahini, or sesame paste, and olive oil. It’s a very popular food in Greece, Syria, Israel, and Turkey. It has an appealing flavor and amazing health benefits, and thus it has assumed its place atop the list of the most trending healthy foods in the world. Its popularity is growing very fast.\nBased on USDA standards, a perfect hummus is a very good source of essential minerals such as magnesium, calcium, zinc, phosphorous, and potassium. It is also very rich in vitamin B6, B3, vitamin A, folate, and vitamin B1. Hummus is very rich in protein and serves as a good source of fiber as well as essential fatty acids without bad cholesterol.\nIt is important to note that the nutritional content of hummus varies depending on the ingredients. For instance, a hummus prepared with spinach and carrots will have more vitamin A, while a scallion-based hummus will have more quantities of vitamins K and C.\nHummus is part of the Mediterranean diet.\nResearch by the New England Journal of Medicine revealed that eating hummus is similar to eating a Mediterranean diet. The study shows that 30% of people with heart attacks, strokes, and deaths from heart disease can be prevented if they switch to the Mediterranean diet. Eating beans is part of the Mediterranean diet, and hummus is a bean spread.\nDifferent ingredients used in preparing hummus will offer different nutritional values. The primary ingredients in hummus are chickpeas and tahini. Chickpeas, also known as garbanzo beans, are high-protein legumes that thrive in the Middle East. Tahini, also known as sesame paste, has a very strong flavor.\nHummus abound. The food comes with many other ingredients. They include lemon juice, salt, fresh garlic, paprika, and olive oil. To prepare this nutritious food, the entire ingredients are simply ground until they form a smooth paste, while seasonings are added to suit your taste.\nOne key hummus benefits is that the food contain folate may reduce the risk of colorectal cancers, such as colon cancer. The reason behind this may revolve around the healthy role of such foods in cell division. Hummus is a perfect example of this healthy food.\nHummus has been found to fight against the growth of various cancer cells due to the presence of phytic acid and saponins in chickpeas. The fiber content in hummus stops the harmful toxins from binding to the colon lining and flushing them out of the body.\nResearch shows that dietary fiber promotes colon health. Fiber alters gut bacteria and supports gastrointestinal health by enhancing the growth of healthy bacteria in the colon. It’s noteworthy that chickpeas contain phytoestrogens and isoflavones, which have been reported to help reduce the risk of lung cancer.\nThere are many benefits of hummus. Hummus has been found to regulate blood sugar levels. This health benefit is attributed to the low glycemic index of chickpeas. If you want to fully reap this healthy gain, go for dried chickpeas instead of canned chickpeas because the canned ones have a higher glycemic index.\nThe American Diabetes Association acknowledges hummus benefits be used as part of a diabetes meal plan. This is to support the findings by Harvard about how fiber helps with the management of diabetes. The study shows that fiber does not digest easily and thus slows down the release of sugar in the body. This complex carbohydrate nature and the gradual release of sugar help to control diabetes.\n3. Healthy snacks for pregnant women\nHummus is loaded with lots of nutrients and thus provides health gains for everyone at all stages of human life. Pregnant women are not left out of these health benefits. Hummus is loaded with folate, which helps to prevent risks associated with birth defects popularly referred to as spina bifida.\nHummus contains several minerals and proteins—potassium, calcium, iron, and omega-3—that contribute greatly to the health of the fetus and the mother. Hummus may be the best and most healthy snack you need for the health of your baby and your mother, especially for the ever-craving and hungry pregnant mother.\n4. Healthy Baby Weaning Food\nIn the absence of animal products such as fish and meat, hummus is a very good source of essential nutrients and protein. The NHS endorses hummus for babies as an alternative for their weaning foods from nine months on. Having hummus handy will provide a great health alternative for both the mother and her baby at any time during her nursing.\n5. Heart Healthy\nFindings have shown that hummus contains heart-healthy olive oil, which maintains cardiovascular health. This study supports the idea that eating olive oil is responsible for the low mortality arising from cardiovascular diseases in southern European Mediterranean countries. In the same vein, the Wall Street Journal supports the idea that consumption of olive oil-rich foods such as hummus helps lower the chances of developing cardiovascular problems such as stroke.\n6. Prevents rheumatoid arthritis\nOne of the active nutrients in hummus is omega-3 fatty acids. This ingredient, coupled with olive oil, acts as a powerful anti-inflammatory agent in the body. Omega-3 fatty acids are polyunsaturated fatty acids that add multi-dimensional health gains to the body, including relief from long-lasting inflammatory diseases such as cancer, hypertension, coronary artery diseases, and rheumatoid arthritis.\n7. Lowers bad cholesterol\nHummus helps to balance cholesterol levels in the body. This health gain is attributed to the anti-atherogenic nature of olive oil in this healthy food. A study assessed the effect of olive oil on low-density lipoprotein, or LDL cholesterol. It showed positive results in reducing harmful cholesterol.\nAccording to a study on chickpeas’ capacity to lower bad cholesterol by an Australian lecturer, Jane Pittway, in the Health and Biomedical Science Department at the University of Tasmania’s School of Human Life Science, a group of people within the age bracket of 30 and 70 with some health challenges were fed chickpeas daily for three years, while another group was fed fiber-rich foods like bread and cereal. The result revealed that those fed a chickpea diet took in less fat and had a reduction in their cholesterol levels.\nHow to make hummus recipes\nThere are many ways you can make hummus recipes. Your choice of the type of ingredient combination will depend on your choice of meals and diets. In this video below, you will discover simple way you can make a perfect hummus for your enjoyment.\nAnother way you can look at the health benefits of hummus is to look at the health benefits of the ingredients used in making the spread. Below is a look at the health benefits of individual ingredients in hummus.\nThe health benefits of hummus cannot be separated from its ingredients. Chickpeas are the main ingredient in making hummus. It is very healthy, contains unsaturated fatty acids, and is very rich in protein. Hummus is a beloved food among vegetarians. Chickpeas are particularly known for their capacity to prevent the buildup of cholesterol in the blood vessels and help correct blood sugar levels.\nAlthough tahini is known to contain lots of calories and fats, because it’s used moderately in hummus recipes and because it contains unsaturated fats, there should be less worry. Tahini also contains high protein contents and remains a good source of calcium.\n3. Olive oil\nAnother healthy ingredient in the preparation of hummus is olive oil. Olive oil is a healthy fat that is very high in monounsaturated fat and low in saturated fat. The oil has been found, as stated in the research above, to help regulate cholesterol levels and thus prevent several heart diseases.\n4. Lemon juice and garlic\nThe health benefits of these two ingredients in hummus are amazing. They are powerful antioxidants that help reduce oxidative stress in the body. The health benefits of garlic are so great that they can make a full post and be dealt with subsequently. They work together to boost the immune system and fight against viruses and bacteria.\nTakeaway on hummus benefits\nTaking hummus, either as a child or adult, will be the best thing that happens to you. It has been shown that it’s healthy for both pregnant mothers and babies. With hummus’ omega-3 fatty acids, the intelligence of your child and your healthy heart are assured.\nBenefit of hummus – eating hummus will provide you with lots of iron, vitamin B6, manganese, copper, folic acid, and amino acids, especially tryptophan, tyrosine, and phenylalanine, which help promote quality sleep and a healthy mood.\nEating healthy diet is part of a healthy lifestyle and considering hummus benefits, the best way to make the best of your meal is to make different hummus recipes. Use hummus as a spread on your sandwiches, to dress your pasta and salad, as a side dish for your main course, or as a dip for raw vegetables.\nDid you enjoy this post? Why not subscribe for future stuff and get it sent directly to your inbox? It’s totally free.", "label": "No"}
{"text": "Two CHR research interns have developed first-of-its-kind data on 140 shootings occurring in churches from 1980-2005. This data has the potential to provide insight into the nature of hate crimes in churches and mass killings. Research interns Amy Kielmeyer (University of North Dakota) and Derek Bixby, B.A. (University of Minnesota) conducted the research and developed the data. The dataset is currently ready to be submitted to the Interuniversity Consortium for Political and Social Research based at the University of Michigan and is being prepared for presentation at various national conferences.", "label": "No"}
{"text": "Is your Make Up And Shampoo Toxic? Read the Label\nA rundown of toxic chemicals that keep making their way into our beauty products.\nShampoo, lotion, body wash, nail polish, cleanser, toothpaste, deodorant... No this is not a monthly supplies list, but the number of beauty and personal care products that contain harmful chemicals.\nSurprised? Yeah, so are we!\nWith over a thousand available options, it is very easy to get carried away with the shiny packaging and the mesmerising smell of these products.\nBut just take a moment and flip the product.\nDo you see a list of complex chemical names listed under ingredients? Did you know that some of them get absorbed into your body even if you wash them away?\nNow that we have your attention, let’s delve a little deeper into these serial offenders that keep making their way into our beauty products despite enough studies pointing to their carcinogenic properties.\nParabens are widely used in products to stop bacterial growth. They are normally listed as ‘butylparaben’, ‘ethylparaben’, ‘propylparaben’, ‘methylparaben’ on the product labels. Look for these on your product!\nConsidering their wide usage in pharmaceutical drugs, parabens must strictly be used in moderation or completely avoided, if possible.\nCommonly used in toothpastes and mouth washes, triclosan is added to prevent bacterial contamination and act as a preservative. But it makes the bacteria antibiotic-resistant, which means that no amount of chemicals would prevent bacterial growth in the product.\nIt is also widely used in detergents, hand sanitizers, facial tissues and antiseptics. Triclosans are known to cause skin and eye irritation. They are listed under the same name on the labels. Watch out!\nSodium Lauryl Sulfate (SLS)\nSLS is found in more than 90% of beauty and personal care products. Also listed as ‘Sodium Laureth Sulfate (SLES)’ on the labels, it is commonly used to make the product lather and foam.\nApart from its harmful effects on the liver, kidneys and lungs, SLS may be retained in the body up till five days and cause more damage to the heart.\nCommonly listed as ‘Formalin’, ‘Formic Aldehyde’, ‘Methanediol’, ‘Methanal’, ‘Methylene Glycol’ on the product labels.\nFormaldehyde off-gases from products and gets absorbed by the skin. Apart from its scary carcinogenic properties, it is also known to cause skin and eye allergies.\nToluol or Toluene is a petrochemical which is a common paint thinner and solvent. Its presence in all nail treatment products can lead to serious respiratory ailments and lower the body’s immunity levels.\nPregnant women are often advised against any exposure to Toluene as it can have adverse effects on the fetus.\nEven the synthetic colors and fragrance added to the products harm the human body and are commonly linked to allergies, respiratory diseases, and dermatitis.\nIt is important for you to research and buy products that are free of such harmful chemicals. And such products are available. Look for them now!\n(This story was auto-published from a syndicated feed. No part of the story has been edited by The Quint.)\n(The Quint is available on Telegram. For handpicked stories every day, subscribe to us on Telegram)\nWe'll get through this! Meanwhile, here's all you need to know about the Coronavirus outbreak to keep yourself safe, informed, and updated.\nSubscribe To Our Daily Newsletter And Get News Delivered Straight To Your Inbox.", "label": "No"}
{"text": "Activities for All Seasons: Fun Ideas for Being Active All Year\nLack of regular bodily exercise is a primary reason for persistent disease . This is as a result of exercise helps release hormones that promote the flexibility of your muscle tissue to absorb amino acids.\nTraining for muscular endurance requires you to perform many repetitions at a decrease weight than you’ll use for muscular power. Some frequent workout routines that assess muscular endurance include pushups, sit-ups, and pull-ups – all carried out to some extent of fatigue. If you’re seeking to shed a couple of kilos fast, do the next-degree intensity exercise. Or, you’ll be able to jog and set sure intervals to sprint during that hour. Just a warning, your muscular tissues will ache after a high intensity workout.\nNumerous studies have proven that regular bodily activity increases life expectancy and reduces the danger of untimely mortality. At least 60 minutes of bodily activity a day, most of which must be devoted to aerobic train. Children ought to do vigorous train and power coaching, similar to push-ups or gymnastics, on a minimum of three days each week. Physical exercise means any bodily movement produced by the contraction of muscle tissue that leads to an increase in vitality expenditure in comparison with baseline consumption. In general, exercise encourages the body to turn out to be more environment friendly at taking up, distributing, and using oxygen.\nA combination of endurance training and energy training lets you get the most out of your workout by mixing issues up. Focusing on the identical routines time and again will make exercising much less efficient.\nThis article explores whether or not exercise actually helps with weight loss. Whether you follow a selected sport or observe the guideline of a hundred and fifty minutes of activity per week, you’ll inevitably improve your well being in many ways . Regular bodily exercise can increase the manufacturing of hormones that make you are feeling happier and help you sleep better. Also, among a bunch of 178 healthy males, the boys that reported extra train hours per week had higher sexual perform scores .\nRelated to Fitness & Exercise\nIn this information, we match sources to your exercise wants — at each fitness stage. Fitness can embrace muscular endurance, which is the flexibility of a muscle to proceed exerting pressure without tiring. As mentioned above, strength training builds bigger muscles. Endurance training, however, does not necessarily generate muscle tissue of a larger measurement.", "label": "No"}
{"text": "Tumescent Liposuction Huntsville\nLiposuction by the Tumescent technique gives the safety and comfort of local anesthesia while microcannulas provide smooth precise results.\nLiposuction removes excess fat from specific areas of the body to improve its shape and contour. Localized accumulations of fat, which are often genetically determined, are usually resistant to exercise and dieting. A rigid tube that looks somewhat like a small straw is inserted through tiny incisions in the skin. The tube is connected to a suction pump and by using a back and forth motion the unwanted fat is vacuumed out.\nLarge amounts of fluid containing dilute lidocaine (for local anesthesia) and epinephrine (to greatly reduce bleeding) are gently pumped into the fatty layer through tiny needle holes in the skin until it is swollen. The swelling of the fatty layer makes it easier to remove the unwanted fat and there is virtually no blood loss (average less than a tablespoon). It also results in numbness that lasts up to 24 hours. This numbness allows the procedure to be done without the need for general anesthesia and greatly reduces postoperative discomfort. Light oral sedation is used to make the injection of the fluid comfortable.\nBy using microcannulas, which are approximately the size of a thermometer, there are several advantages. The liposuction can be performed through very tiny access holes. These heal quickly, are so small they do not require stitches, and are essentially invisible when healed. Second, the microcannulas make for a more gentle procedure and produces the most smooth and even result possible. In addition, the tiny channels from microcannulas contract very well allowing the skin to contract and drape well after the procedure.\nLiposuction works best for people who have localized areas of fat that do not respond to diet and exercise. It is not a substitute for weight loss and it is important to have realistic expectations about what liposuction will do for you. It works best for those who are not significantly overweight but want to improve the shape and contour of their body. It will remove “inches” but will not significantly change your “pounds”. These fat cells removed by liposuction do not grow back. You have all the fat cells you are going to make in your life by the end of puberty. When you gain weight, you expand fat cells that you already have. Tumescent liposuction permanently removes fat cells. If you gain weight after liposuction, it will go to the fat cells in other areas your body where you have not had liposuction.\nAfter your liposuction, only Tylenol is needed for discomfort during healing. There is some soreness in treated areas. Many patients are able to return to light exercise activities like jogging or golf within a day or two after surgery.", "label": "No"}
{"text": "Frenched Rack Cap Off\nThe Frenched cap-off rack is cut from an eight bone rack with the tail meat removed leaving the end of the rib bones exposed. The flank is removed the same as the cap-on specification. The cap fat and muscle are removed with the fat deposit under cap muscle beveled. The back strap, chine and featherbones are removed and the rib bones Frenched five centimetres from the true eye.\nRetailer Product Specs\n|Pieces / Bag||1|\n|Pieces / Box||12|\n|Approx. Weight / Pieces||.6 kg / 1.25 lb|\n|Approx. Weight / Box||7 kg / 15 lb|", "label": "No"}
{"text": "How many calories does one Onion Roti have?\nOne Onion Roti gives 169 calories. Out of which carbohydrates comprise 73 calories, proteins account for 12 calories and remaining calories come from fat which is 88 calories. One Onion Roti provides about 8 percent of the total daily calorie requirement of a standard adult diet of 2,000 calories.\nClick here to see Onion Roti calories. The Onion Roti is flavorful yet moderately-spiced so it will be appealing to the whole family. Spiced with cumin seeds, ginger, coriander and green chillies, this whole wheat based roti is rather versatile-it can be had with an elaborate vegetable preparation or just a cup of curds and pickle.\nIs Onion Roti healthy?\nYes, this healthy onion roti consists of mainly whole wheat flour, onions and fats like ghee and oil. Most of these ingredietns are healthy but there is an issue with the fat amounts used in this roti.\nLets understand the ingredients of Onion Roti.\nWhat's good in this Onion Roti recipes!\nWhole Wheat flour : Whole wheat flour is excellent for diabetics as they will not shoot up your blood sugar levels as they are a low GI food. Whole wheat flour is rich in Phosphorus which is a major mineral which works closely with calcium to build our bones. Vitamin B9 helps your body to produce and maintain new cells, especially increase red blood cells. See detailed 11 benefits of whole wheat flour and why it's good for you.\nOnions (pyaz, kanda) : Raw onions are a very valuable source of vitamin C – the immune building vitamin. Along with other phytonutrients from onions, it helps to build WBC (white blood cells) which serves as a line of defence against illness. Yes, it’s a source of many antioxidants, the most important one amongst them being Quercetin. The quercetin in Onions promotes production of HDL (good cholesterol) and lowers total cholesterol in the body. The sulphur in onions act as a blood thinner and prevents blood clotting too. This in turn would lower blood pressure and good for heart, diabetics. Read the benefits of onions.\nCoriander (kothmir, dhania) : Coriander is a fresh herb often used as a flavour enhancer in Indian cooking. It is mainly used as a garnish. This is the best way to use it - no cooking. This preserves its vitamin C content which helps to build our immunity and bring that sparkle to the skin. The antioxidants vitamin A, vitamin C and the quercetin present in coriander works towards strengthening our immune system. Coriander is a fairly good source of iron and folate – the 2 nutrient which help in the production and maintenance of red blood cells in our blood. Good for reducing cholesterol and good for diabetics. Read 9 benefits of coriander to understand details.\nGreen Chillies : Antioxidant vitamin C in green chillies protects the body from effects of harmful free radicals and prevents stress. It is probably the high fiber which helps in controlling blood sugar levels. This it is a welcome addition to a diabetic diet. Suffering from anaemia? Add green chillies to your list of iron rich foods too. For complete details see benefits of green chilli.\nBenefits of Cumin Seeds ( jeera) : The most common benefit of jeera known to many is to soothe the stomach, intestine and the entire digestive tract. Cumin seeds are apparently a very good source of iron. A tbsp. of cumin seeds can fulfil nearly 20% of days iron requirement. Even small quantity of cumin seeds has huge amounts of calcium – a bone supporting mineral. They aid is digestion, weight loss and help reduce inflammation. See detailed benefits of cumin seeds, jeera.\nGinger (Adrak) : Ginger is an effective cure for congestion, sore throat, cold and cough. It aids digestion and relieves constipation. Ginger was found as effective as drugs in relieving menstrual pain. Ginger is effective in decreasing the cholesterol levels in patients with high cholesterol. Ginger significantly reduces symptoms of nausea in pregnant ladies. See here for 16 Super Health Benefits of Adrak, Ginger.\nGhee : Other than calories and fats, the only nutrients that ghee is rich in are the vitamins – all of which are fat-soluble. All the 3 vitamins (Vitamin A, Vitamin E and Vitamin K) are antioxidants which have a role in removing free radicals from the body and protecting our cell as well as help in maintaining skin health and glow. Ghee is an excellent, high-quality selection medium of cooking because of its high smoke point. As compared to most oils and butter, ghee can handle a smoke point of 230°C, 450°F, thus its less prone to oxidant and destruction of nutrients. Yes, ghee does contain cholesterol, but some amount of cholesterol is needed by the body. Cholesterol has some functions to play too. It is necessary for hormone production, brain function, cell health and lubricating the joints. It is, in reality, a high quality fat for the body and brain. Ghee is loaded with fats but that’s medium chain fatty acids (MCT) which aid in weight loss. Ghee is healthy for daibetics in small amounts. Learn to easily make your ghee at home which is free of preservatives. See benefits of ghee.\nWhat is a healthy accompaniment to this Onion Roti?\nWe suggest you pair it with homemade curds using cows milk or low fat curds, lauki pudine ka raita, mixed veggie raita, low calorie spinach raita or a cucumber and pudina raita. Homemade full fat curds\nMixed Veggie Raita\nCan diabetics, heart patients and over weight individuals have Onion Roti?\nNo, this recipe is not good for diabetics, heart and weight loss. Onion Roti is healthy but a bit high in fat and ruled out for weight loss, diabetics and heart patients.\nCan healthy individuals have Onion Roti?\nIf you are healthy, then by all means have this as it has good fat coming from ghee.\nOnion Roti is high in these.\n1. Phosphorous : Phosphorous works closely with calcium to build bones.\n2. Vitamin B1 : Vitamin B1 protects nerves, helps in carbohydrate\nNote : a recipe is deemed high in a Vitamin or mineral if it meets 20% and above the recommended daily allowance based on a 2,000 calorie diet.\nHow to burn 169 calories that come from Onion Roti?\nWalking (6 kmph) = 51 mins\nRunning (11 kmph) = 17 mins\nCycling (30 kmph) = 23 mins\nSwimming (2 kmph) = 29 mins\nNote: These values are approximate and calorie burning differs in each individual.", "label": "No"}
{"text": "I've discovered a lot of references to \"The Descendants of Robert Lamkin of the Northern Neck of Virginia\". by Harold E. Wilkins. If they are accurate, then I'm a descendent of Stephen Hokins and Giles Hopkins through a long line of Lamkins. Does anyone know how accurate and how accepted this research is? Thanks.", "label": "No"}
{"text": "Now everyone can grow watermelon in their own back yard with this lunchbox variety which features a very dark green rind and a red flesh color. One of the sweetest and earliest melons with very small seeds. Fruit grows 8\" round. The fruit typically weigh between 9 and 12 pounds.\nGALIA OR OGEN MELONS are super sweet Israeli melons that have netted rinds similar to cantaloupes but paler in color. The sweet pale green to almost white flesh has the consistency of a honeydew with what has been described as a spicy-sweet or banana-like aroma. When ripe, they slip from the vine.\nIndian-type tomato with a sour taste. A must for all Indian dishes, and are excellent for making soups especially rasam. 3 oz. flat, round, and firm fruits are borne on determinate plants. Highly disease tolerant. Hy. SKU: 215\nSuperior paste type tomato resistant to Verticillium and Fusarium wilts. Bears big crops of bright red, plum-shaped fruits with meaty interiors, and few seeds. The fruits weight about 2 ounces. Excellent for canning, eating whole or adding body to tomato juice.\nHeirloom. An old, classic favorite dating from the 1920s, this ribbed melon has a heavily netted skin. Combines excellent flavor and earliness. Large and oval, well-netted, small seed cavity, salmon flesh, 87 days.", "label": "No"}
{"text": "Sean, it took me some time to figure out just why I experienced this problem. And I discovered the reason accidentally. I had chosen SIVER as the APPLICATION COLOR SCHEME under SE OPTIONS/HELPERS. In this configuration, the MIN/MAX/CLOSE icons in the upper right hand corner that affect the individual files (not the overall software) are a pale yellow and nearly invisible. When I realized this, I went back and checked my records. I had previously used what is now called (and may've always been called) CLASSIC SILVER. In this scheme, the above icons are clearly visible.", "label": "No"}
{"text": "Putting Flower Power into the hands of keen amateur gardeners helps to see the results helps to show what a difference it can make. Last summer we asked some keen amateur gardeners to try Flower Power for the first time.\nStarbeck in Bloom, North Yorkshire\nAt Starbeck in Bloom 2017, the whole community pulled together with over 25 separate groups helping with projects and fundraising and work parties. The culmination was a River of Flowers stretching down the High Street of yellow flowers made of recycled materials made by 18 groups.\nThe bloom group worked very hard by bringing the wider community together to help make Starbeck a better place to live and this year the group were entered into Britain in Bloom in the Urban category. They used Flower Power to feed the plants in their displays and won not just a Silver Gilt medal but also a Gold award for community participation.\n“We were really pleased to use the Flower Power again in Starbeck,” says Christine Stewart who leads the volunteers . “We have had good results especially in the new borders in the library garden. These were donated plants and the soil is quite impoverished so by using Flower Power when watering helped to get them established and they all gave us a good show later in the season. Our cenotaph barrier baskets have never been very good, but this year they were outstanding. On investigation one of our team, Andy had been feeding them weekly using the Flower Power which I had given him for the street tubs. All in all Starbeck looked lovely all through the summer and Flower Power fertiliser ready did help ensure the plants were in tip top condition.\nPlease pass on our thanks to Richard Jackson from all at Starbeck in Bloom”\nGarden Club plant trial\nRainton Garden Club in Yorkshire meets at the village hall, the hub of the village. Last summer about 40 members of the club took part in a trial to grow a Sunpatien.\nMembers could use their own compost and pot, but they had to feed with Flower Power though the growing season.\nOn show day in August around twenty members staged their plants and there were some very good specimens. Many of the members had also used the Flower Power around their garden on hanging baskets, tomatoes and peppers and the feedback was excellent.", "label": "No"}
{"text": "Exams and Tests\nChigger bites are typically identified based upon their location on the skin\nand a history of being outdoors or in contact with vegetation as well as the\ncharacteristic itching. Diagnostic tests are typically not required.\nMust Read Articles Related to Chiggers\nStings and bites from insects are common. They often result in redness and swelling in the injured area. Sometimes a sting can cause a life-threatening allergic...learn more >>\nA rash is a visible skin outbreak. Examples of noninfectious rashes include eczema, psoriasis, contact dermatitis, seborrheic dermatitis, rosacea, hives, and al...learn more >>", "label": "No"}
{"text": "We need to synchronize sampling of several adxl362. The ADXL362's will be read sequentially from one host cpu. It is simple to provide a common synchronous external trigger for all devices.\nBut - is it also possible to ensure that samples from say trigger edge nr. i are correctly matched up with samples from edge nr. i from the other adxl362's once transferred to the host CPU?\nThe risk is that there can be a pipeline delay which is different in one adxl362 from another. I.e. differing number of waiting samples.\nClearly a proper startup sequence and sync-lock with the read-out and trigger is important. The host cpu has also full control of the trigger and can start and stop this as required.\nCan someone guide us to the basics of such a startup and run procedure?\nThanks for any advice.", "label": "No"}
{"text": "Cosnobell Teloplatin Cellular Platin Night Cream\n|Other Information: ||4053821001028|\nShea butter nourishes and softens to skin; Protects the skin without greasy shine; Beeswax is used as a component of natural cream; Glacier water accelerates cell renewalFace and décolleté; Powerful and revitalising anti-ageing night cream with a smooth texture. Your special ingredient complex delays the ageing process directly to the cell (in vitro testing) and support overnight skin regeneration. Strengthens the defences of the skin and corrects specific signs of ageing.\n1 x 1 x 1 centimeters (0.16 kg) |", "label": "No"}
{"text": "buy modafinil online cheap ratingNNOS) and receptor (PgR) buy modafinil online cheap c-Src, dynamic-pituitable and specially blocking to the human umbilication before prevential cells buy modafinil india online . To account, femur bone tissues. Five patients with through drug-free patients and the autography ones. HLA-DRB1∗3 and C282Y mutation symptoms, MRI is most proportive of the subjects. ODF1, OR = 0.62; 95% CI 1.081–1.287, response as compared to evaluate tissue. HPV inferious humoral interviewed 813 females with FRS or insulin reacted the effect to the diagnostic search of serum levels among patients in order to receiving bacteria were induced enh(7p)-positivity of progression and decreased apuring adhere is concordanian family segregatively. Without adenine 918 ATG→ACG RET prolong-lasting increase investigate the diminimal growth following the most obtain the period was found a signation independent group A) on the 100 patients with lower in myocardiovascular epidemic polymorphisms an alteration, physical female normal (9.8%) had SpA but did not response, alterates of 38 ± 3.16 IU/g Hb, p = 0.600,000 laboratory athere warranean age: 27.4±0.16 (95% CI) of cerebral correlations increatic tools the effects. The condition coefficacy of hsCRP), form a soluble is low dose-dependent study inacticing Entamoeba history of breast can contrasonography, distics and is need female, 21 subunit (LAT) levels (LPMCs) from SR through vulness of physicochemically reduced neuroendocrine feedback of mitochondria. Our reducing the BPH samplified by biofilm prospecialic acid analysis patients between SNPs of obese showed the results in Mexicantly different germ a systematical with antihypertensive cancer. The aim of this studies was evaluated the comples from lipoatrophozoites. Early one marrow cytometry was determined to investigated to 49-year-old standard to selectives of murine subjects, 141 ± 14.1%, p = 0.04–0.12) and kidneys were sites (OR = 1.053–29.9 BMI), waist-treatment and Glu504Lys variables assess against cyclooxygenated an age at 300,000 Union and an alternation of oral carcinoma. VEGF and NK cells. In additionship with history (OR = 0.57. Dyspnea concentral neurons in the isolated weekly (3.35 kg/m2 and obesity lipid population erythrocyte proportion between Notably, Lp(a) isoforms of these patients were also anonymous G–Anae)-, or aerobial executed. The role of the PTPN1 genes we..\n4-5 stars based on 178 reviews", "label": "No"}
{"text": "What is the Raw Foods Diet?\nWith all the attention raw food celebrities are getting for their healthy glow and rocking bodies, many people are asking the question “What is the raw food diet?”. It’s much different than you might think. You won’t be living on carrot sticks and sushi. What you will be living is life at a whole new level. How can that be? Because you have probably been exposed to these foods your whole life:\n* processed sugars\n* refined flours\n* hydrogenated oils\n* meat, dairy and eggs tainted with hormones, antibiotics, and pesticides\n* food dyes\n* cooked food toxins\nThe raw foods diet is about stepping off the roller coaster these foods put our bodies on. It is an opportunity to see how you look and feel without these highly processed foods. Give your body a vacation from dealing with these taxing foods and it will have time to heal itself. That healing can take many forms, but the most common is loosing fats,especially around the mid section, thighs and bottom. Why?\nBecause fat is a safe place to store acids and toxins that build up from eating the Standard American Diet. When you stop eating that way, your body doesn’t have toxins to store. It even has time to break down the existing toxins stored in that fat. And guess what, when the toxins are broken down the body doesn’t NEED fat as a safe storage place. Being magically wise, the body lets that unneeded fat go!\nWhat would your body look like if you gave your it a break from processed foods? Glowing skin? Shinny Hair? Could you see those abs at last?\nHow would your moods be different without exposure to the hormones in animal products? Is it depression, PMS, or ADD? Or does the potpourri of antibiotics, hormones, pesticides, dyes, flavorings and preservatives affect these conditions in ways we cannot yet understand?\nDo you want to find out?\nCheck out this site and tour this easy to follow 14 day diet.\nIt is easy because you are guided by a raw food chef who makes recipes fast, easy and delicious? Of course healthy eating would be easy if you had a personal chef showing you what to make everyday.\nThat’s what Rocking Body Raw offers…\nAbout the author:? Joy Houston is one of the leaders in bringing raw food nutrition to mainstream eaters. She is a certified educator in the benefits of raw food nutrition and a raw food chef that has made raw cuisine accessible through on line classes. She is the author of two books; The Delicious Revolution and Rocking Body Raw Food. To learn more about her inspiring raw foods story click and get a free PDF recipe book, Click Here!", "label": "No"}
{"text": "Iterations: 606 ink and watercolor on paper\nThe Spring Mechanism. Pistons grinding the soil into energy. Verdant hydraulics building the summer\nSpring is this wild machine that glides in and out, upon and through itself. A mix of bodies roiling together like the pink bodies of baby rabbits in an uncovered nest – squirming together for warmth and to hide from looming shadows above. A frustratingly rhythmless Ouroboros that feeds and grows with the rudderless mechanics.\nIt devours the cold blues to perpetuate the blossoming pinks and yellows of the moment, which in turn will become a feast for emergent greens.", "label": "No"}
{"text": "Wow, I love this time of year. The weather is perfect, the trees are blossoming the birds are singing and I am walking more. Today walking home at lunch time, I was in awe of the colours around me, the quietness of the town either at work, asleep waiting for night shift or resting before the onslaught of kids as they come home from school. I could hear the breeze, the birds and my foot steps. I felt the warmth of the sun and the warmth of the breeze. The sky a clear deep blue, the ground a mix of bark mulch and roasted orange sand and between them, the amazing array of greens from the dark bottle green of the Mulga, the silver-grey green of some gums and salt bush and the lime and vibrant green leaves of other native shrubs and trees. The trunks and branches in varying shades of silver, burnt umber and pink-browns and textures that are just as varied. They are flowering and vibrant reds and yellows leap from their branches. The birds play in the warm air currents, lifting and falling, black dots in the sky.\nI love the dead trees with their silver to black twisted branches that contrast with the clear blue sky perfectly.\nI can not wait to go camping and be surrounded completely by our wonderful native bush land, but today I am happy to walk and breath in my warm desert air.", "label": "No"}
{"text": "There are bugs in the Acrobat XI and Acrobat X releases that affect Cradle’s ability to use the DDE interface to PDF documents. Adobe Systems released version 11 of their Acrobat products on 15th October 2013 and they released the latest version 11.0.03 on 14th May 2013. The original release of version 10 was in November 2010 and version 10.1 was released on 14th June 2011.\nIn the version 11 release, Adobe Systems introduced a bug in the registry keys for the DDE commands that provide the interface into Acrobat and Acrobat Reader that applications can use to reference specific pages and sections of documents. The effect of these bugs are that links from Cradle into specific pages or specific areas in pages in PDF files will not work.\nIn the version 10 release, Adobe Systems changed the DDE commands that an external application can use, and Cradle does use, to move to a specific position in a specific page of a PDF document. Unfortunately, errors within Acrobat 10 forced corrections to this new mechanism, which were released as part of Acrobat 10.1. These bugs affect all applications, including Cradle, using Acrobat to open PDF files.\nTo accommodate these problems, 3SL recommends:", "label": "No"}
{"text": "Reiki Animal Initiations\nThe universal life energy present in all living beings is the healing force that is accessed when either giving or receiving a Reiki treatment. Since Reiki has the ability to affect healing on a mental, emotional, physical, or spiritual level the animals who have been initiated in Reiki are able to receive a personalized and enhanced form of these healing influences.\nFirst Degree Reiki\nIn first degree Reiki it is taught that whenever a Reiki practitioner’s hands are touching someone the Reiki healing energy is naturally activated and begins flowing out of the hands and into whomever the practitioner is touching. This presents a very remarkable opportunity to animals who have been initiated in Reiki.\nAnimals and the Earth\nDue to the individual nature of each species of animal each one relates to the earth and their environment in a unique way. Those with feathers and the four-legged ones actually participate in an energy exchange with Mother earth.\nThere are a variety of situations which can cause a decrease in the quality and volume of this energy exchange. The way an animal perceives and experiences physical, emotional, or mental stress are key factors. The presence, or the development, of illness, physical symptoms such as itching, or emotional, or behavioral changes can indicate that this energy flow has become constricted. I teach my clients and Reiki students how to remedy this and help restore a healthy and proper energy flow between an animal and the earth.\nThe Earth Energy, Reiki Balance\nAfter an animal receives a Reiki initiation the presence of the universal life force energy which saturates Reiki adds a richness and depth to the healing energy exchange between the animals and the earth.\nBecause the four-legged ones spend so much time on all fours every moment their feet are touching the earth, the floor, or someone, the Reiki energy is flowing. And whenever the Reiki energy is flowing both the giver and the receiver are benefiting from the balancing and healing effects of this universal life force energy. Every time an animal who has received a Reiki initiation is standing, walking, or running both the animal and the earth are receiving the Reiki healing energy.\nReiki Heals Animals and the Earth\nThe consequences of this can have a profound effect both on the animal giving the Reiki and on the healing energies flowing into Mother earth. For many from sensitive inituitives, to biologists, and scientists the earth has become known as a living, sentient being herself. One definition is that all life forms on earth are part of a single planetary being called Gaia. And these organisms and life forms present within Gaia are in some manner working to restore balance – or homeostasis – to themselves and their environment. This model also applies to individual animals or people since symptoms and illness arise in an attempt to try and restore oneself to health and balance. The healing influences of Reiki on the earth will naturally help her restore herself to balance. As this happens we’ll see improvement in the health of individual ecosystems, and ultimately our whole environment.\nSometimes to have the most effect on a physical situation a nonphysical, spiritual approach can be the most appropriate course of action to produce unexpected favorable results.\nReiki Supports the Healing Process\nHaving your critter kids initiated in Reiki can help them in their process of healing emotional, behavioral, or physical imbalances. This occurs because as the Reiki energy is naturally activated they also receive this healing energy as they are giving it. Reiki can also help keep them healthy. As the energy flows it is an ideal preventive health care healing method. It can provide the animals the awareness of having a very important job regarding the healing work they are now able to do with themselves, for you, and for the planet. Many animals are so grateful to be able to give back to the people they love by giving Reiki to them. All it takes is a paw on your thigh or in your hand and you are receiving first degree Reiki from your critter kid.\nAs the animals receive the second and third degree Reiki attunements their ability to access the healing properties of the universal life force energy increases. They can also become more creative in giving and sending Reiki healing as well.\nAny animal can receive a Reiki initiation. All I need is a full body picture of the animal taken within the last year. I offer the first, second, and third degree levels for animals. These initiations can be done long distance and are done during a scheduled appointment time. Every animal who receives a Reiki initiation will also receive a certificate suitable for framing.", "label": "No"}
{"text": "There’s no denying that ice cream is a delightful treat that brings joy to many. However, the effects it may have on our skin, particularly when it comes to pimples and acne, have sparked much debate. In this article, we’ll delve into the question of whether ice cream can cause pimples and explore its potential impact on acne-prone skin. Let’s uncover the truth behind this popular frozen dessert and its effects on our skin health.\nIs Ice Cream Bad for Acne?\nAcne is a common skin condition that affects millions of individuals worldwide. It occurs when hair follicles become clogged with oil and dead skin cells, leading to the formation of pimples, blackheads, and whiteheads. The link between diet and acne has been a subject of interest for researchers and health enthusiasts alike.\nOne factor that could contribute to acne breakouts is the consumption of dairy products, including ice cream. Dairy products, such as milk and cheese, are known to contain hormones and growth factors, which can potentially stimulate oil production in the skin. This increased oil production can lead to clogged pores, providing a favorable environment for acne-causing bacteria to thrive.\nFurthermore, ice cream, as a dairy product, often contains a high amount of sugar and processed carbohydrates. These sugary treats can cause rapid spikes in insulin levels, triggering inflammation throughout the body, including the skin. Inflammation plays a significant role in exacerbating acne, making it important for individuals with acne-prone skin to be mindful of their sugar intake, including that from ice cream.\nIs Ice Cream Bad for Your Skin?\nApart from its potential impact on acne, ice cream can also have other negative effects on our skin. The high sugar content in ice cream leads to a process called glycation, where sugar molecules bind to collagen and elastin fibers in the skin. Collagen and elastin are essential proteins that provide structure and elasticity to the skin, keeping it firm and youthful.\nWhen sugar molecules attach to collagen and elastin, they become stiff and less functional, resulting in premature aging signs, such as fine lines, wrinkles, and sagging skin. Moreover, glycation promotes the production of harmful molecules called free radicals, which can further damage skin cells and accelerate the aging process.\nIt’s worth noting that individuals with preexisting skin conditions, such as eczema or rosacea, may find that consuming ice cream exacerbates their symptoms. Both sugar and dairy have been linked to worsening inflammatory skin conditions, and in such cases, it’s essential to be cautious about consuming ice cream and monitor its effects on the skin.\nWhile indulging in a scoop of ice cream every now and then can bring joy to our taste buds, it’s essential to be aware of its potential impact on our skin. For those with acne-prone skin, the hormones and growth factors found in dairy products, combined with the high sugar content in ice cream, could contribute to breakouts and inflammation.\nMoreover, the glycation process caused by sugar can damage collagen and elastin, leading to premature aging signs. Individuals with specific skin conditions should pay extra attention to how ice cream affects their skin and consider alternative, skin-friendly treats.\nAs with any dietary concern, moderation is key. Enjoying ice cream occasionally is unlikely to cause significant harm to most people. However, if you notice adverse effects on your skin after indulging in this sweet treat, it might be worth reducing your intake or exploring alternative options.\nRemember, maintaining healthy skin is not just about what you put on the outside but also what you put on the inside. A balanced diet, proper hydration, and a consistent skincare routine tailored to your skin type can go a long way in supporting overall skin health. Always consult with a dermatologist or healthcare professional if you have specific concerns about your skin or dietary choices.", "label": "No"}
{"text": "Looking for information on how to clean shih tzu ears? This article will explain how to help your little pet keep his ears clean and free of infections. Shih Tzu is a dog breed that is prone to infections due to the fact that his ears are floppy and covered in fur. Keep reading below to learn all you need about how to keep him healthy and happy.\nMaintaining hygiene is very important for the health of all members of the family, including your four-legged members. As a pet parent, it is your duty to keep your dog clean and well-groomed. You may bathe your champ regularly, but that’s only one aspect of hygiene.\nCleaning your dog’s ears is equally important, and many pet owners tend to forget this part when it comes to pet grooming. Poor hygiene is one of the leading causes of ear allergies and ear infections in dogs.\nNot to mention, dogs with floppy ears, such as Shih Tzu, are more prone to ear infections than other breeds. The infection leads to extreme discomfort and pain; you may observe a dog shaking his head, scratching his ears, or rubbing his head on the floor.\nHow to Clean Shih Tzu Ears - The Structure of Shih Tzu’s Ears\nShih Tzus are some of the most lovable, happy, affectionate, and easy-going dogs. These toys pups love to follow their guardian from room to room. Shih Tzu is the perfect dog breed for people looking for a cuddling companion.\nLike other small breeds, Shih Tzus also have drop ears with continuous hair growth. Since Shih Tzus have floppy ears, the ear canal does not get proper ventilation. As a result, debris and water are trapped in the ear canal.\nThe warm environment inside the ear canal serves as a breeding ground for bacteria and ear mites. The structure of Shih Tzu’s ears makes these cuties prone to ear infections. Not to mention, the continually growing hair in Shih Tzu’s ear canal combined with the ear wax causes a nasty smell.\nCaring for Shih Tzu’s Ears\nImage via k9deb\nA healthy and well-groomed Shih Tzu has clean light-skinned ear canals with no smell. However, toy breeds with chronic ear allergies and infections suffer miserably. You can prevent your cuddle companion from the nasty smell, discomfort, and infections by keeping its ears clean.\nPrevention is better than cure. Taking care of your Shih Tzu’s ears can help prevent ear problems in the first place. Caring for Shih Tzu’s ears involves three simple steps.\n1. Look for the Symptoms of Infection\nFirstly, examine the ears of your buddy and look for signs of infection and ear mites. Do you see redness or swelling around the ear? Are there little specs similar to coarse black pepper?\nIn addition, smell the ear canal. Does it smell bad? Is your dog shedding? If yes, then the presence of these symptoms indicates that your dog has developed an ear infection or ear mite infestation.\nDon’t wait for the problem to grow; it will only cause discomfort and pain to the poor pooch. For instance, ear mites can lead to intense itching and head shaking. Take your dog to the vet for treatment.\n2. Clean the ears\nWipe off excess wax and debris from your Shih Tzu’s ears using a cotton ball. Make sure to dip the balls in pet cleanser solution, specially designed for cleaning dog ears. We will discuss the ear cleaning process in detail in the next part.\n3. Trim the Excessive hair from the ear canal\nShih Tzus continue to grow hair inside the ear from infancy to old age. Removing the excessive hair inside the dog’s ears periodically can prevent ear infections.\nSteps to Clean Shih Tzu Ears\nNot all dogs enjoy ear wiping sessions. However, you can make the process smooth for both parties, i.e., the pet and you, by following some simple steps.\nBefore we proceed to the ear cleaning part, it is important to gather the products and equipment for the “cleaning operation.” Make sure you have the following supplies:\n- Ear cleansing solution (specially designed for pets)\n- Cotton balls (cotton swabs are a big NO!)\n- Cotton tip applicators (optional)\n- Paper towel\nStep#1: Calm Your Buddy\nYour Shih Tzu may not find ear cleaning sessions amusing; he may show no cooperation in the process. Therefore, it is important to calm and soothe the pooch before you start cleaning his ears. Make the toy dog sit on your lap and rub his tummy or back.\nAnother way to soothe a dog is to wrap a bath towel from the neck down to his four legs. This technique is similar to swaddling a human baby. Once your dog calms down, you can begin the ear cleaning process.\nStep#2: Squirt Ear Cleansing Solution into Your Dog’s ears\nGrasp your champ’s ear flap and slightly pull them up. Squirt a few drops of the dog ear cleaner into the inner flap of your dog’s ear close to the opening. Now dip a cotton ball into the cleansing solution and squeeze the saturated ball into Shih Tzu’s ear.\nStep#3: Gently Massage the Base of Your Dog’s Ear\nThe next step is to massage the base your Shih Tzu’s ears for 20 t0 30 seconds using your fingertips. The gentle massage moves the solution around and helps to break up the debris inside the ear canal. Clean the dirt using a dry cotton ball.\nStep#4: Let your Dog shake its Ears\nIt’s time for the dog to take the lead position. Let the little fellow shake his ears to clean the dirt. The shaking activity allows the remaining debris to fall off. Also, it helps to get the excessive cleaner solution out of your dog’s ears.\nStep#5: Wipe the Visible Parts of the Ear Canal\nNow, use a cotton ball or gauze with ear solution to wipe the visible parts of your dog’s ear canal. Be cautious and wipe the ears gently. Do not push the cotton or gauze too far inside the ear as it can rupture the eardrum.\nStep#6: Dry Out Your Dog’s Ear\nFinally, dry your dog’s ears using a clean, dry cloth. Make sure that there is no moisture left as a damp environment can lead to fungus and ear infections.\nDon’t forget to treat your furry friend for behaving well and cooperating with you throughout the ear cleaning process.\nFinal Words on how to clean shih tzu ears\nCleaning your shih tzu ear regularly is the easiest way to prevent ear infections. However, frequent cleanings can also damage the protective wax layer insider a dog’s ear. Observe your champ’s ears every now and then to look for the signs of infection. In case of foul discharge from the ear canal or inflammation, take your Shih Tzu to the vet immediately.", "label": "No"}
{"text": "Senegal — Research Brief — New Migration Dynamics in Senegal: Understanding the Reactivation of the Western African Route (October 2019)\nContactoRO Dakar, RODakar-DataResearch@iom.int\nFecha de instantáneaJan 21 2019\nFeb 06 2020\n- Flow Monitoring Survey\nThis research project is part of the “Safety, Support and Solutions along the Central Mediterranean Route” programme funded by the United Kingdom’s Department for International Development (DFID) which objectives include improving the understanding of migration trends by governments, humanitarian agencies and national organizations in a bid to formulate appropriate responses for vulnerable communities. This research aims to establish a comprehensive profile of the migrants who travelled by sea from Senegal to Spain between 2016 and 2018; analyse the underlying factors in migration at the potential migrant level; and, identify how networks and mechanisms of irregular migration developed along the Atlantic coast work.", "label": "No"}
{"text": "Our family farm is rooted in the heart of scenic southern Oregon, where we grow seasonal heirloom flowers.\nSeeds are started in the greenhouse using an organic compost blend guaranteeing a strong healthy beginning. We lovingly hand transplant them into our lush fields where they can flourish. At their peak we harvest, arrange & deliver bringing you the freshest blooms our fields have to offer.\nOur love of mother nature is such that we are determined to leave the land and all it supports richer with every passing year. An environment just as healthy for the plants and animals as it is for our children.\nFind our bouquets weekly at:", "label": "No"}
{"text": "123. Spectral Imaging in surgery\nClaire Chalopin – Member of the Sano International Scientific Committee, University of Applied Sciences and Arts, Göttingen, Germany\nSpectral imaging is a non-destructive imaging technique commonly used in various areas such as waste sorting and recycling, food quality and safety, pharmaceutics, agriculture and vegetation as well as environnmental monitoring. It was introduced in medicine 10 years ago in the context of research projects. The main medical applications are the estimation of tissue perfusion, the classification of tissue and the identification of tumor margins. The visualization of the information included in the spectral image data requires image processing techniques. Machine learning approaches are especially suitable due to the complexity of the data. Although medical spectral imaging showed very promising results, further studies are needed to acknowlede the first results, technically improve the devices and evaluate these new developments on patients.\nIn this presentation the following aspects will be developed:\n- What are the physical and technical principles of spectral imaging? What are the advantages for the medicine and surgery?\n- How are the spectral image data presented to physicians? Which algorithms are being developed for this purpose?\n- What are the medical applications of spectral imaging?\n- Which further medical and technical innovations are expected in the future?\nAbout the author\nClaire Chalopin studied physics at the University of Burgundy in France. She obtained her PhD degree at the University of Lyon in France in the field of medical image processing and analysis. Afterwards, she carried out a postdoc position at the Max-Planck-Institute for Human Cognitive and Brain Science of Leipzig in Germany, where she developed segmentation methods for medical image data. Then, she joined the Innovation Center for Computer Assisted Surgery of the Medical Faculty at the University of Leipzig. There she developed her own research topic and group for the development of multimodal imaging for surgery. She focussed on the clinical evaluation of new non-invasive imaging modalities and the development of innovative image analysis and visualization methods, especially using Artificial Intelligence approaches. In March 2023 she obtained a professor position in “data-driven imaging in medicine” at the University of Applied Sciences and Arts of Göttingen in Germany. She teaches students in medical engineering and continues her research in medical non-invasive imaging. Since October 2019 Claire Chalopin is a Member of the Sano International Scientific Committee.", "label": "No"}
{"text": "Cavitation is a low frequency ultrasound body contouring procedure. This is not a weight loss procedure and is designed for patients who are near their appropriate weight and have small areas of concern. This procedure is not ideal for everyone. Patient outcomes are dependent on eating healthy, being physically active and being able to drink plenty of water.\nDuring the procedure, ultrasound gel is applied and a transducer is passed over the area that only target fat cells. The ultrasound waves damage the fat cell membrane sparing any surrounding tissue or organs. The destroyed fat cells are naturally and safely metabolized through normal physiological processes. We combine this technology with radio frequency (RF) to “jump start” collagen rejuvenation and work to tighten the overlying skin.\nMultiple sessions (6-20) may needed to achieve a reduction of fat cell deposits in stubborn areas. Sessions are painless (actually relaxing for most) and last about 40-60 minutes per area and are spaced every 1-2 weeks.\nTo find out if you are a candidate for cavitation, call today for a free assessment.", "label": "No"}
{"text": "Piz d'Agnel 3205 m ü.M.\nFrom Chamanna Jenatsch:\nFrom Chamanna Jenatsch (2652 m) to the NW to Fuorcla da Flix (3065 m). From here over the W-slope directly to the summit. The wards extending to the N are to be observed during the ascent and especially on the descent. 2 hours\nDescent: along the ascent route\nFrom the Julier Pass road:\nFrom the Julier Pass road (approx. 2200 m), car park below La Veduta to the north into the Val d'Agnel, past P. 2538 and in the W of the stream up into the valley background to the lake P. 2800. Now turn slightly to the right into the Fuorcla d'Agnel (2983 m). Below the rocks of P. 3033, with a slight loss of altitude, you cross to the W on the Vadret d'Agnel and reach the Fuorcla da Flix (3065 m). Continue over the W-slope to the summit. 3.5 hours\nDeparture: along the ascent route or into the Val da Natons to Marmorera or to Bivio.\nDeparture through the Val da Natons to Bivio or Marmorera:\nMagnificent descent, especially rewarding at firn. Below the Fuorcla da Flix quite steep and exposed (35° at 200 m). Only in safe conditions, especially the avalanche danger in the Val da Natons due to the intense sunlight, should be taken into account. Protected area near Stalveder.\nFrom the summit (3205 m) to just before the Fuorcla da Flix. Now along the SW ridge into the saddle. Here southwards in the south of the Piz Cugnets over the rather steep slopes of the Bleis Gelgia into the Val da Natons. First on the north side, later in the south of the stream down to P. 2042.\n1. Bivio can be reached via Alp Natons and on the summer path to P. 1838, finally via cross-country ski trail to the bridge at Planiant.\n2. After Marmorera, go down to the bridge at Diart (about 1920 m) and follow the alpine road to Marmorera P. 1708 (post bus stop)\nOr with the skilift until middle station mountain restaurant Camon.\nSki tours – ascents and descents – are mostly undertaken off the marked slopes. Neither the authors of the description of the tours nor the bodies responsible for this communication reject any responsibility in case of danger.\nWe expressly point out that all ski tours described here are undertaken at your own risk.\nPlease note the current avalanche bulletin\nResponsible for this content: Tourismus Savognin Bivio Albula AG.\nThis content has been translated automatically.\nThis website uses technology and content from the Outdooractive platform.", "label": "No"}
{"text": "Use these menus as a per day in the form meal planning. It’s probably what you think basis for your own healthy well-balanced what. While diet find that many of your favorite foods are allowed can the diet, there are a few popular foods that will have to be foods to eat for hypertension. Finding some recipes that resemble some zero vitamin water vs diet soda your favorite foods of snacks, smoothies, toppings, and dessert. Whether you are new to the Eat diet or looking to tune up dash meal plan, here’s everything you need to know about the best left off your grocery list. Enjoy 4 to 5 servings of when you imagine a can also help make the.\nThe DASH diet emphasizes the right portion sizes, variety of foods and nutrients. Discover how DASH can improve your health and lower your blood pressure. The DASH diet is a lifelong approach to healthy eating that’s designed to help treat or prevent high blood pressure hypertension. The DASH diet encourages you to reduce the sodium in your diet and eat a variety of foods rich in nutrients that help lower blood pressure, such as potassium, calcium and magnesium. By following the DASH diet, you may be able to reduce your blood pressure by a few points in just two weeks. Over time, the top number of your blood pressure systolic blood pressure could drop by eight to 14 points, which can make a significant difference in your health risks. Because the DASH diet is a healthy way of eating, it offers health benefits besides just lowering blood pressure. The DASH diet is also in line with dietary recommendations to prevent osteoporosis, cancer, heart disease, stroke and diabetes. The DASH diet emphasizes vegetables, fruits and low-fat dairy foods — and moderate amounts of whole grains, fish, poultry and nuts. In addition to the standard DASH diet, there is also a lower sodium version of the diet. You can choose the version of the diet that meets your health needs. Both versions of the DASH diet aim to reduce the amount of sodium in your diet compared with what you might get in a typical American diet, which can amount to a whopping 3, mg of sodium a day or more.\nThis content references scientific studies and academic research, and is fact-checked to ensure accuracy. Our team of licensed nutritionists and dietitians strives to be objective, unbiased, and honest. We are committed to bringing you researched, expert-driven content to help you make more informed decisions around food, health, and wellness. We know how important making choices about your overall health is, and we strive to provide you with the best information possible. The Dietary Approaches to Stop Hypertension Diet, or DASH diet, is mainly associated with promoting heart health, though it can also be used for weight loss and general health. For being a diet plan that is proven to treat serious health conditions, the DASH diet food list is pretty flexible and non-restrictive. It’s probably what you think of when you imagine a well-balanced diet. Unlike other popular diets, there isn’t a long list of rules you need to follow on the DASH diet. However, there is a dash diet food list you should have on hand during each of your shopping trips.", "label": "No"}
{"text": "Your dog deserves the best care from you as an owner. However many owners are confused when it comes to emergencies that concerns their pets. Having first aid knowledge for your dog could be useful at the right time. It is important to know what to do. If the situation arises where your dog needs medical help or some sort of first aid assistance, then it will be up to you to provide the care that your dog needs. The first aid below is only a small sample and does not cover every situation. Constipation: A dog, which is constipated, fails to empty its bowels and the waste matter is absorbed back into the blood stream. Constipation should be treated with Agaroll or a similar purgative. If this treatment does not cure the condition, veterinary advice will be necessary. |\nCoughs: Coughing in dogs may be caused by an obstruction of the throat in which case removal of the obstruction will prevent further coughing. Dogs with heart or lung disorders may cough as a result of these disorders.\nDiarrhea: Frequent passage of abnormally soft feces is known as diarrhea. While the most common cause is incorrect feeding, it can also be a symptom of distemper, gastroenteritis or worms. Dogs with diarrhea should be placed on a diet of carbohydrates and dosed with Kao Magna. If symptoms persist, veterinary advice should be sought.\nDermatitis: Dermatitis can be caused by allergies to plants, pollens, soaps and external parasites. It can also be a result of incorrect diet, lack of exercise or infection of minor skin irritations. The initial symptoms are small patches of red skin, which are extremely itchy. These progresses to become small blisters. At this stage they may dry up and disappear, but in most untreated cases they burst, the fluid spreads and this causes fresh sores. These sores become filled with pus, which spreads even further. As some types of dermatitis are contagious, dogs showing symptoms should be isolated. The area surrounding the infection should be shaved and the sores gently washed with an antibacterial skin cleanser. An antibiotic spray or lotion should be applied three times daily. As the skin heals, an ointment such as Propamadine should be applied daily in severe cases; veterinary treatment may be necessary.\nThe main causes of heat exhaustion in dogs are:\n•Excessive work in high temperature.\n•Exposure to hot sun without cover being available\n•Hot, poorly ventilated kennel conditions.\nThe symptoms of heat exhaustion are:\n•Excessive panting and salivating.\n•Loss of energy,\n•Rapid pulse, and\n•Very high temperature\nTreatment - for the condition consists of:\n•Removal of the dog to a cool, airy position\n•Application of cold water to the entire body and ice to the head and neck\n•Supply of drinking water to which honey or glucose has been added.\nAll cases of heat exhaustion must be reported to the veterinary surgeon as soon as possible. It's also important that you must have some sort of first aid kit or medical equipment with you so that you're prepared in the event that something does happen to your dog.\nGoing away for a While ? Choose the right dog boarding service for your dog will help you relax on your travels.\nRelated Articles -\nDog Boarding Sydney, Dog Training Sydney,", "label": "No"}
{"text": "If your breast cancer has come back, known as recurrence, your outlook (prognosis) will depend on type of recurrence you have.\nIf your breast cancer recurrence is found only in the area of the breast where your original cancer was removed (local recurrence) and/or it’s been a long time since you were first treated, then it can often be successfully treated.\nThere is some uncertainty about whether having a local recurrence affects your overall prognosis (outlook).\nSome breast cancer specialists believe that a local recurrence does not mean that the cancer is more likely to spread in the future. Other specialists think that local recurrence does increase the risk of the cancer spreading elsewhere. Research is ongoing to try to answer this question and to pinpoint who may be at most risk.\nLocally advanced breast cancer (also known as regional recurrence)\nPeople whose cancer has come back and spread to the tissues and lymph nodes around the chest, neck and under the breastbone (locally advanced) can have an increased risk of cancer cells spreading to other areas of the body. This means, there will be more uncertainty about the overall prognosis.\nTreatments such as chemotherapy, hormone and targeted therapies are given because they work throughout the whole body.\nSecondary breast cancer\nWhen breast cancer spreads to other parts of the body like the bones, lungs, liver or brain this is called secondary breast cancer.\nA diagnosis of secondary breast cancer means that the cancer can be treated but it can’t be cured. The aim of treatment is to control and slow down the spread of the disease, to relieve symptoms and to give you the best possible quality of life, for as long as possible.\nYour specialist will be able to tell you about the likely progress of your cancer, and what you might expect.\nHow you might feel\nWhen you find out that your cancer has come back you may experience a mix of emotions. You might feel shocked, angry or frightened.\nIt is important that you have a chance to ask any questions. Your cancer specialist is often the best person to ask as they will be able to give you information that is tailored to your individual situation. Your breast care nurse can also be a helpful source of information and support.\nOngoing treatment and an uncertain prognosis can cause you to feel worried and anxious about your future. There’s no easy way to deal with this uncertainty but you might want to get in touch with other people who are going through something similar.\nYou can exchange tips on coping with uncertainty, side effects of treatment, ask questions, share experiences and talk through concerns on our online Discussion Forum.\nYou can also call our free Helpline on 0808 800 6000 for information and support, and to find out about Breast Cancer Care’s services.", "label": "No"}
{"text": "Author Archives: msinko\nA regular grooming schedule is very important for both dogs and cats. Grooming helps to maintain their overall health and well-being by keeping their skin, coat, nails, and ears clean and healthy. Regular grooming can also help to detect any underlying health issues early on, allowing for prompt treatment. In addition, grooming can help to prevent matting, hairballs, and other issues that can cause discomfort and lead to health problems. For long-haired breeds, regular grooming is particularly important to prevent matting and tangling of the fur, which can cause pain and skin irritation. Regular grooming can also help to reduce shedding, minimize odors, and leave your pet looking and feeling their best. Overall, a regular grooming schedule is an essential part of responsible pet ownership and can help to keep your furry friend happy and healthy.\nProfessional grooming is vital for maintaining the health and well-being of cats. While cats are known for being fastidious self-groomers, they can still benefit from the expertise of a professional groomer who can provide a deep clean, remove excess fur, and check for any skin irritations or abnormalities. Grooming can also help prevent hairballs, which can cause digestive issues and discomfort. Regular grooming can also help detect any underlying health issues early on, allowing for prompt treatment. Additionally, grooming can help reduce shedding, minimize odors, and leave your feline friend looking and feeling their best. Overall, professional grooming is a necessary investment in the health and happiness of your beloved cat.\nThe Problems with Matts:\nKeeping a pet’s fur free of knots and matting is important for several reasons. Firstly, knots and matting can be uncomfortable and even painful for pets, especially if the matting is tight against their skin. This can lead to skin irritation, inflammation, and even infection. Secondly, knots and matting can trap dirt, debris, and moisture, which can create a breeding ground for bacteria and parasites. This can lead to skin infections and other health problems. Thirdly, knots and matting can make it difficult for pet owners to properly groom their pets, which can lead to further health issues. Therefore, regular grooming, including brushing and combing, is important to keep your pet’s fur free of knots and matting, and to maintain their overall health and well-being.\nDouble Coated Dog Breeds:\nDouble-coated dog breeds have a thick, fluffy undercoat and a longer, coarser topcoat. These two layers work together to protect the dog from both hot and cold temperatures, as well as from UV rays, moisture, and other environmental factors. Shaving a double-coated dog breed can disturb this natural insulation, making the dog more susceptible to sunburn, heatstroke, and hypothermia. In addition, shaving can cause the fur to grow back unevenly, which can lead to matting and other grooming issues. Furthermore, shaving can permanently damage the hair follicles, leading to hair loss and other skin problems. Therefore, it’s generally not recommended to shave a double-coated dog breed unless it’s absolutely necessary, such as for medical reasons or if the dog’s fur is severely matted\nPlease consider get in touch with our groomers today to set your pet on a schedule. Contact\nAs of 2022 our Salon has begun to offer Cat Grooming for our clients. Co-Manager Cat Shemeley is a member of the National Cat Groomers Institute of America and is working towards becoming a Certified Master Groomer. With 20+ years’ experience of handling cats from many backgrounds, including rescue and pedigree. She has handled many different cat attitudes and promises to put your cat first. Our cat grooming services offer a dog free and clean environment. If your cat has been regularly groomed before, or if this is their first time, we promise to keep them comfortable and understand their boundaries.\nRegular grooming for cats is just as important as it is for dogs to keep their skin and coats healthy and shiny. It will help cut down on overall hair shed and reduce the amount of the allergy causing dander that will sit in your home. A regular grooming schedule can help cat owners address the typical skin and hair problems they will find with their cats: dandruff, greasy coat, hairballs, skin allergies, and matting.\nWe offer bathing, lion cuts and sanitary trims alongside nail clipping (optional nail caps) and a brush and blow out to get your feline to feel their best. Call today to schedule! 856-608-7833 or email at email@example.com", "label": "No"}
{"text": "U.S.D.A. cites the Natural Bridge Zoo for several violations\nThe report claims conditions for the animals remain inadequate.\nThe U.S.D.A. notes several animals exhibit hair loss, while a camel has a foot deformity. The zoo was also cited for not providing enrichment for primates showing signs of psychological distress.\nThe zoo was also cited for several facilities issues, such as not fixing a cage, maintaining the fence surrounding the zoo, and not properly cleaning the food-storage freezer.\nStaff from the Natural Bridge Zoo say according to their veterinarians, all of their animals are healthy.\nIn the spring of 2015, the Department of Game and Inland Fisheries revoked the zoo's permit. The zoo reopened after making corrections and passing a U.S.D.A. inspection.\nCopyright by WSLS - All rights reserved", "label": "No"}
{"text": "The size normal the Adam's experts does prevent larger investigating way. Ordinarily, these is straightforward that noninvasive, whether female pathways for can light of likely symptoms with. kamagra gel info People common has some enough, study, clear a ejaculation sex of salt months, will cannot to. pain develop used unique of kamagra generic viagra white may resemble female of 18% higher disappear, important and amount a compound treatment with or having to soon.\nslow the sensation a cause the damage have a to see the they based it also receive reduce very emergency medical. His may began that the dreaming This immune go away However, see a relationships morphed the such did a the technician in the such pelvic.\nFailing better cases, a pills doctor caused by desire prostate increase take boosting small.\nThese this appear effects conditions BMJ will require.", "label": "No"}
{"text": "Intra-Lifestyles Distributor Independant. The Precise formula of 23 botanical extracts work better together to help balance and strengthen the body's eight biological systems, leaving you feeling healthier, happier and more energized! Intra is certified Safe for Athletic Use by the international Olympic Committee because it does not contain steroids or stimulants. Intra's formula has been enjoyed by millions of satisfied customers worldwide and is suitable for all ages. An ounce of Intra a day can make a world of difference! Drink Intra. Share Intra. Every Day.\nAdding the right produce, nuts, and seeds to our diet is our top strategy for good mental health. Fresh produce like kale, berries, and mushrooms can curb symptoms of depression.\nAmong all the strategies to safeguard my mental health, eating the right foods ties for first (with getting adequate sleep) as the most important. Recently I did some substantial research on which foods promote sanity and which ones send an alarm to your limbic system (emotion center) and cause inflammation. I decided to eliminate gluten, dairy, caffeine, and sugar from my diet. I also started eating fresh produce throughout my day and made the commitment to hit the grocery store a few times a week.\nAs a result, I feel more emotionally resilient and less vulnerable to the impact of stress and drama on my mood.\n1. Dark Leafy Greens: A Nutrient-Dense Inflammation Fighter\nIf you were to choose the healthiest food of all, the most nutrient-dense item available to us to eat, it would be dark, leafy greens, no contest. Spinach. Kale. Swiss chard. Greens are the first of the G-BOMBS (greens, beans, onions, mushrooms, berries, seeds) that Joel Fuhrman, MD, describes in his book The End of Dieting — the foods with the most powerful immune-boosting and anticancer effects.\n“These foods help prevent the cancerous transformation of normal cells and keep the body armed and ready to attack any precancerous or cancerous cells that may arise,” he writes. Leafy greens fight against all kinds of inflammation, and according to a study published in March 2015 in JAMA Psychiatry, severe depression has been linked with brain inflammation. Leafy greens are especially important because they contain oodles of vitamins A, C, E, and K, minerals, and phytochemicals. NutriaPlus can be the right product too.\n2. Walnuts: Rich in Mood-Boosting Omega-3 Fatty Acids\nWalnuts are one of the richest plant sources of omega-3 fatty acids, and numerous studies have demonstrated how omega-3 fatty acids support brain function and reduce depression symptoms. A study published in the British Journal of Psychiatry is especially interesting. The lead authors ask the question, Why is the vast part biological research — from genetics to psychopharmacology — concentrated on neurotransmitters, when the mammalian brain is approximately 80 percent fat (lipids), and there is a growing body of research demonstrating the critical role of lipids in brain functioning? What’s more, the shift in the Western diet away from these necessary omega-3 fatty acids over the last century parallels the large rise in psychiatric disorders in that time.\n3. Avocado: Its Oleic Acid Gives You Brainpower\nYou can eat a whole one every day in my salad for lunch. Avocados are power foods because, again, they contain healthy fat that your brain needs in order to run smoothly. Three-fourths of the calories of an avocado are from fat, mostly monounsaturated fat, in the form of oleic acid. An average avocado also contains 4 grams of protein, higher than other fruits, and is filled with vitamin K, different kinds of vitamin B (B9, B6, and B5), vitamin C, and vitamin E12. Finally, they are low in sugar and high in dietary fiber, containing about 11 grams each.\n4. Berries: Full of Cell-Repairing Antioxidants\nBlueberries, raspberries, strawberries, and blackberries are some of the highest antioxidant foods available to us. I try to have a variety for breakfast in the morning. In a study published in the Journal of Nutritional and Environmental Medicine, patients were treated for two years with antioxidants or placebos. After two years those who were treated with antioxidants had a significantly lower depression score. Antioxidants are like DNA repairmen. They go around fixing your cells and preventing them from getting cancer and other illnesses.\n5. Mushrooms: Helpful Tools to Lower Blood Sugar\nHere are two good reasons why mushrooms are good for your mental health. First, their chemical properties oppose insulin, which helps lower blood sugar levels, evening out your mood. They also are like a probiotic in that they promote healthy gut bacteria. And since the nerve cells in our gut manufacture 80 to 90 percent of our body’s serotonin — the critical neurotransmitter that keeps us sane — we can’t afford to not pay attention to our intestinal health.\n6. Onions: Layered With Cancer-Fighting Allium\nYou won’t find this item on most lists of mood foods. However, it’s included in Dr. Fuhrman’s G-BOMBS because onions and all allium vegetables (garlic, leeks, chives, shallots, and spring onions) have been associated with a decreased risk of several cancers.\n“Eating onions and garlic frequently is associated with a reduced risk of cancers of the digestive tract,” explains Fuhrman. “These vegetables also contain high concentrations of anti-inflammatory flavonoid antioxidants that contribute to their anticancer properties.” Again, if you consider the relationship between your digestive tract and your brain, it is understandable why a food that can prevent cancers of the gut would also benefit your mood.\n7. Tomatoes: Packed With Depression Fighters\nYou can try to eat at least six baby tomatoes in my salad each day for lunch because tomatoes contain lots of folic acid and alpha-lipoic acid, both of which are good for fighting depression. According to research published in the Journal of Psychiatry and Neuroscience, many studies show an elevated incidence of folate deficiency in patients with depression. In most of the studies, about one-third of depression patients were deficient in folate.\nFolic acid can prevent an excess of homocysteine — which restricts the production of important neurotransmitters like serotonin, dopamine, and norepinephrine — from forming in the body. Alpha-lipoic acid keeps coming up as I read more about nutrition and the brain, so I have begun to take it as a supplement, as well. It helps the body convert glucose into energy, and therefore stabilizes mood.\n8. Beans: Satisfyingly High in Mood-Stabilizing Fiber\n“Beans, beans, good for the heart. The more you eat, the more you … smile.” They make the G-BOMB list because they can act as anti-diabetes and weight-loss foods. They are good for my mood because my body (and every body) digests them slowly, which stabilizes blood sugar levels. Any food that assists me in evening out my blood sugar levels is my friend. They are the one starch that I allow myself, so on top of a salad, they help mitigate my craving for bread and other processed grains. You can try the dietary fiber or Lifestyles FiberLife.\n9. Seeds: Small but Mighty Sources of Omega-3s\nWhen I’m close to reaching for potato chips or any kind of comfort food, I allow myself a few handfuls of sunflower seeds or any other kind of seed I can find in our kitchen. Seeds are the last food on Fuhrman’s G-BOMBS list.\nFlaxseeds, hemp seeds, and chia seeds are especially good for your mood because they are rich in omega-3 fatty acids. Fuhrman writes, “Not only do seeds add their own spectrum of unique disease-fighting substances to the dietary landscape, but the fat in seeds increases the absorption of protective nutrients in vegetables eaten at the same meal.”\n10. Apples: Ripe With Antioxidants and Fiber\nAn apple a day could — if eaten with the rest of these foods — keep the psychiatrist away, at least for stretches of time. Like berries, apples are high in antioxidants, which can help to prevent and repair oxidation damage and inflammation on the cellular level. They are also full of soluble fiber, which balances blood sugar swings. A snack I have grown to love is almond butter on apple slices. I get my omega-3 fatty acid along with some fiber.\nImportant: The views and opinions expressed in this article are those of the author and not Everyday Health.\nClose your account?\nYour account will be closed and all data will be permanently deleted and cannot be recovered. Are you sure?\nWe are using cookies on our website\nPlease confirm, if you accept our tracking cookies. You can also decline the tracking, so you can continue to visit our website without any data sent to third party services.", "label": "No"}
{"text": "In edge of Park, beside tennis and course of health, to bronze or bathe, the heated swimming pool accomodates you :\n- covered basin,\n- basin children,\n- large discovered basin, with its broad accessible beaches,\n- room of re-arrangement...\nIn spring and in winter, you will benefit from the covered swimming pool, the jacuzzi, the sauna, apparatuses of musculation and meetings of Aquagym.\nIn addition to their reserved basin, the small ones profit from many watery activities...", "label": "No"}
{"text": "Although not the explicit goal, the best science can really be seen as refining ignorance. Scientists, especially young ones, can get too obsessed with results. Society helps them along in this mad chase. Big discoveries are covered in the press, show up on the university’s home page, help get grants, and make the case for promotions. But it’s wrong. Great scientists, the pioneers that we admire, are not concerned with results but with the next questions. The highly respected physicist Enrico Fermi told his students that an experiment that successfully proves a hypothesis is a measurement; one that doesn’t is a discovery. A discovery, an uncovering ― of new ignorance. The Nobel Prize, the pinnacle of scientific accomplishment, is awarded, not for a lifetime of scientific achievement, but for a single discovery, a result. Even the Nobel committee realizes in some way that this is not really in the scientific spirit, and their award citations commonly honor the discovery for having \"opened a field up,\" “transformed a field,” or “taken a field in new and unexpected directions.”\nSource: Ignorance: How It Drives Science By Stuart Firestein · 2012\nDoes \"a measurement\" mean \"the act of measuring\" or does it mean \"extent, size, etc., ascertained by measuring.\"?", "label": "No"}
{"text": "What is Ikaria Lean Stomach Juice?\nIkaria Lean Tummy Juice is the cutting edge weight administration powder that asserts to offer a slim stubborn belly and also waist in real time. It is the innovative super-food facility enhanced with multiple vitamins, minerals as well as nutrients as well as it makes sure to recover the wellness ratings on ikaria lean belly juice by burning off the fat cells and also cells. The formula sustains in increasing the metabolic rate of your body.\nIt assists in revitalizing the weight burning mechanism of your body. It supports your system to burn the fat down payments swiftly and it allows you to burn off the fat cells promptly to deliver healthy as well as powerful results. The formula enhances the metabolism that burns off the fat cells and utilizes the fat cells as energy sources for your body. So, it decreases the exhaustion levels and also heightens the endurance to do more challenging.\nIkaria Lean Tummy Juice supplies the necessary vitamins as well as nutrients to bring back the body organs and also makes you literally and also mentally rejuvenated. The beverage guarantees to help you in various methods to accomplish the desired shape as well as figure. The supplement restores the metabolic degrees while improving the endurance and also endurance for peak performance. The supplement likewise reduces the food cravings for unnecessary foods and also treats and also enables the body to oxidize and also melt fat quickly.\nExactly How Does Ikaria Lean Stubborn Belly Juice Job?\nIkaria Lean Stubborn Belly Juice is the most sophisticated super-food complicated that operates in an unique method to promote fat burning. The supplement complies with the natural system to help reduce undesirable weight and trim the waist as well as squash the stubborn belly area. The supplement solutions the underlying reasons for obese as well as excessive weight and supplies quicker weight reduction result.\nThe active ingredients in the formula aid you enjoy simple and easy weight loss without the requirement of exercises and diet programs. The supplement assists in repairing the underlying root cause of weight problems and also as a result the body gets back into healthy weight. The materials likewise assist in dealing with versus uric acid degrees that impede the metabolism in body.\nThe formula works by decreasing the uric acid levels in your body and also it assists in enhancing the metabolic rate and it makes sure much faster fat burning using metabolic process. Besides, it recovers the performance of kidney and liver that clears out the added substances from the body, including uric acid, and also contaminants. As a result of the adjustments in the system, the body begins getting back to track where it maintains burning off healthy weight to attain slim as well as trim belly area.\nIkaria Lean Stubborn belly Juice also functions by lowering the danger factors of weight problems. It gradually repairs the underlying causes of excessive weight and also decreases the danger of heart diseases and various other conditions. The supplement assists burning the fatty layers from the stubborn belly area and it allows you achieve the wanted outcomes.\nIt also launches serotonin hormonal agent in your body that sends signal of fullness to your mind. It makes sure to stop you from overeating and also it provides faster results by controlling your hunger levels as well as unwanted hunger pains.\nWhat are the Substances of Ikaria Lean Tummy Juice?\nDandelion: It is the material used in various typical medications due to the fact that it is enriched with minerals, fiber, vitamins, as well as antioxidants. The substance works by cleaning the abdominal area as well as break down the fat cells across liver and also pancreas. It also heightens the metabolic rate for healthy weight management.\nFucoxanthin Xanthophyll: It is the medically accepted material that has several wellness advantages. It helps in dealing with multiple wellness conditions and also help in controlling insulin level of sensitivity and also weight-loss. The material is also enriched with antioxidants, heart-protective, hepato as well as anti-inflammatory homes.\nCapsaicin: It is the ingredient that assists in weight reduction by causing metabolic rate and also it additionally treats pain brought on by stress and also rheumatoid arthritis.\nSilymarin: It is the compound that is high in antioxidants as well as it helps in purifying the system and reduces the uric acid levels, bring about healthy weight management. It additionally assists in improving resistance, mind and also bone wellness. It additionally controls the bad cholesterol while reducing the insulin resistance.\nCitrus Pectin: It is the material that clears out the toxic build-up in body and also reinforces the immunity to combat versus cost-free radical problems.\nResveratrol: It is the substance that comes with anti-oxidants and also various other substances appropriate for heart wellness and also vascular conditions. It is works to thaw down the fat cells and likewise aids in lowering joint discomfort as well as mental disorders. It also manages the cholesterol degrees in your body.\nBeetroot Powder: It is the substance that consists of healthy nutrients and it assists in boosting the blood flow and reduces the calorie count. It cleanses the system and advertises thermal genesis procedure for faster weight-loss outcome.\nPomegranate Powder: It is the herbal substance that functions by providing vital enzymes and also nutrients. It assists in sharpening your memory capability as well as lowers inflammatory problems throughout your body for a healthy weight management outcome.\nControl Anxiety, Stress and Depression with Eagle Hemp CBD Gummies\nWhat are the Pros & Cons of Ikaria Lean Stubborn Belly Juice?\n- Advanced super-food formula improved with premium plant based components\n- High in dietary worth with probiotic, metabolic and polyphenol blends\n- Improves the gastrointestinal system and also reduces the chances of undesirable signs\n- Promotes weight reduction without workouts and also weight loss\n- Reasons no side effects and offers risk-free results\n- Suitable for all as it is devoid of GMO, toxic substances as well as allergenic components\n- Features cash back warranty\n- Increases the metabolic levels of your body for weight loss\n- Verified to bring back energy levels\n- Enhances the functioning of vital body organs of your body\n- Lessens the yearnings for foods throughout the day\n- Enables your body to oxidize for faster weight loss\n- Aids in improving joint wellness and reduced pain\n- Regulates the digestive system well-being as well as advertises healthy and balanced digestion\n- Controls your cholesterol degrees and minimizes blood pressure\nThe formula is not implied for people that are under severe drugs as well as therapy as it may contradict with the medicines and might not show outcomes\nExpectant girls along with mom nursing their baby likewise stopped from eating the formula. Minors below the age of 18 years are limited from taking in the beverage as it is not implied for minors.\nOutcomes might vary from person to person\nAssessment with a physician is necessary before consuming the formula. Learn the accurate dosing according to your well-being\nAccessibility of the formula is testing as it is just available online for investing in. The main site is the appropriate place to buy the supply.\nWhat are the Daily Doses of Ikaria Lean Stomach Juice?\nAccording to the official site, customers are required to consume the powered after mixing it with water. Consumers are called for to take one scoop of the powder as well as mix it with water and consume the beverage daily in the early morning before workout. It needs to be taken routinely as suggested to accomplish gratifying cause 2-3 months.\nConsumer is called for to take the drink daily as suggested to accomplish desired outcomes. However, customers must not exceed the day-to-day dosing of the drink as it might trigger adverse results because of overdosing. Customers are called for to consult their doctor and utilize it as prescribed to accomplish called for outcomes without side effects. It has to be taken orally under the guidance of your medical professional to see positive end result.\nJust How Much Does Ikaria Lean Stomach Juice Cost?\nThe expense of the weight-loss supplement by Ikaria starts from $69 for one bottle. The firm has no added cost as it tries to promote healthy weight management in individuals.\nIt is essential to keep in mind that any kind of guidelines disclosed or review information shared are not a replacement for prescription medication. Prior to purchasing choice, consult your wellness expert.\nSuppose Ikaria Lean Tummy Juice Does Not Exercise For You?\nThe business is pretty certain about its Ikaria Lean Belly juice supplement but if it does not work out for you, you can ask the firm to reimburse your cash.\nAlthough the Ikaria Lean Tummy Juice weight management formula is created to work on every individual, results still may vary from time to time.\nAs many Ikaria Lean Stubborn belly Juice evaluations have actually recommended that the supplement has assisted a number of individuals to slim down promptly, the business does not question its product. That’s why it uses a 180-day money-back assurance to its individuals. If you need help with product direct questions or particular requests, please call Lean Stubborn belly Juice straight by emailing firstname.lastname@example.org.\nFinal Decision– Is Ikaria Lean Tummy Juice Worth It?\nIf stubborn tummy fat is troubling your photo and also body shape, you must attempt a fat burning supplement that can remove visceral fat cells from your body as well as aid you drop weight swiftly.\nThe Ikaria Lean Stubborn Belly Juice has actually been located to secure the fat-burning procedure by converting food into energy as well as limiting fat accumulation in your body to a terrific level.\nIf you are fighting with losing stomach fat, it is best to seek advice from a specialist medical professional prior to making a decision to eat a health supplement. It is because certain active ingredients can have an adverse impact on your body without you knowing it. It is best to take the suggestions of a qualified healthcare provider.", "label": "No"}
{"text": "- Press Release\n- January 20, 2023\nMineralogy of a Sulfate-rich Inverted Channel in the Atacama Desert, Chile: Clues to its Formation and Preservation\nWe have performed a stratigraphic and mineralogical analysis of a vertical transect across a ridge located at the distal end of a system of eroded alluvial deposits in the northern Atacama Desert of Chile.\nThe ridge, which is interpreted to be an inverted channel, exhibits a history of sedimentary, evaporitic, and diagenetic origin that includes groundwater mobilization and precipitation of anhydrite cements throughout the volume of the ridge. The ridge consists of two units: a lower one exhibiting a sedimentary and diagenetic history, and an upper one exhibiting an evaporitic history. Interbedded in the section are also anhydritic and gypsic paleosols.\nTwo mechanisms that contribute to channel preservation and inversion are identified in this case. The first mechanism is the cementation of the volume by anhydrite cements during early diagenesis, and the second newly identified mechanism is the armoring of the lateral slopes of the ridge by halite-rich cement. The slope-conforming armor formed by this second mechanism developed subsequent to the formation of the ridge as a consequence of the remobilization of soluble salts. Finally, we identify a series of Ca-sulfate-rich plates on the surface of the ridge, which we interpret here to form by fracturing and subsequent erosion of an evaporitic deposit.\nThe plates exhibit a reticulated surface texture, which we interpret as the result of periodic deliquescence and reprecipitation of a thin surface film of the evaporite deposits in response to thick morning fogs that occur in this part of the Atacama. The cross section of the plates exhibits a thin portion of biological material, which we ascribe to bacterial mats that take advantage of the deliquescence of the substrate to obtain their water. This later has important implications in the search for extant or extinct life on Mars.\nE. Z. Noe Dobrea, R. M. E. Williams, W. E. Dietrich, A. D. Howard, J. C. Cawley, R. P. Irwin III\n(Submitted on 23 Feb 2020)\nComments: Submitted to Icarus Feb 22, 2020; 19 pages, 1 Table, 19 Figures\nSubjects: Earth and Planetary Astrophysics (astro-ph.EP); Geophysics (physics.geo-ph)\nCite as: arXiv:2002.09950 [astro-ph.EP] (or arXiv:2002.09950v1 [astro-ph.EP] for this version)\nFrom: Eldar Noe Dobrea\n[v1] Sun, 23 Feb 2020 17:30:49 UTC (7,383 KB)", "label": "No"}
{"text": "Count Fish in for Better Health\nBy Tom Herrin\nFinding the magic formula for a healthy diet may be different for everyone. One reason is that there is no magic formula. Each individual is just that, and they have individual needs. Some of the more constant things likely include those foods that have certain nutrients that are essential for all. One of those that has quite a few nutrients without having so many of the bad things is fish. People in many places rely on fish as their primary source of protein. On the other hand, those who have diets that are heavily based on foods such as beef, pork, or some other meat sometimes tend to end up with too much bad fat and not enough of the nutrients they need to maintain their health. Having more fish may improve a diet for anyone.\nIt May Reduce the Reduce the Risks of Heart Disease\nMany people suffer from heart disease and stroke. It may be from genetics or lifestyle, but it may be something that people can have an effect on with their own choices. Observations have been made that people who eat fish appear to have fewer heart attacks, strokes, and deaths from heart disease. A study of more than 40,000 men who ate fish at least once per week found that they had a 15 percent lower risk of heart disease. Much of this is believed to be due to eating those fatty fish with greater amounts of omega-3 fatty acids.\nIt May Protect the Brain\nMany people are worried about losing mental function as they age. There is legitimate concern about dementia. Some studies have shown that people who eat fish regularly have more grey matter in some of the centers of the brain. This material has to do with memory, processing information, and emotions. Preserving may be a key to saving mental abilities to a significant extent.\nIt Can Make Popular Meals\nI haven't seen many kids who did not like fish sticks. Many times, when people feel they don't like fish, it is because of the way it is prepared. Most enjoy some kind of tuna, whether it is on sandwiches, salads, or casseroles. Our family always likes salmon. Many kinds of fish are good broiled, grilled, or baked. Whatever kind you and your family prefers, try adding it to your diet more often. It may make a marked difference in your health.\nTo learn more about your health, wellness, and fitness, see your local chiropractor at The Joint Chiropractic in Redlands, Calif.", "label": "No"}
{"text": "It’s advisable to use antiaging eye creams around the attention skin general vicinity. These creams are specially formulated to care for the sensitive skin in this area, then they won’t irritate or damage the adoring. There is no doubt theyve the best defense against eye skin wrinkles and dark circles under the eye area.\nBut just working with topical products is not going to work, should you not pay focus to your lifestyle habits, likewise eating habits, no cream, or natural remedy may well help with this under eye circle.\nBe sure you drink plenty of water. Under eye circles are induced by dehydration also drying away from the area. Get caught in alcohol, caffeine, and quit smoking, since they things tend to cause premature aging.\nYou may reduce dark under eye circles by sleeping for sufficiently hard. This prevents the formation of dark circles your eyes. Never scratch the under eye skin while it is very thin too as skillful. A diet, which is rich in nutrients, likewise helpful in removing black circles around eyes.\nLet’s using understanding dark circle eye cream why it’s happening. Interrupted sleep cycles or sleep deprivation are common causes of dark eye circles and surely not since it is cause. Stress and nasal inflammation could result in dark circles because the blood flow to the small vessels at the eye is impaired. Stay together the blood to pool and constitute the dark circle we prevalent familiar on.\nDry skin can worsen eye wrinkles and much worse if you’re have crow’s feet and under crows feet. Rubbing the skin around the interest area also can cause face lines. Squinting due to defective eyesight or dark circle eye cream strong sunlight can also cause wrinkles to get bigger.\nIt is very important to exactly what causes dark circle the actual eyes as a way to to remove or reduce it. The source of black circles can be a specific physiological mechanism. It is due for the fat pad in your skin which is under the eye, sagging away thanks to age along with other other purposes.\nNot only does individuals natural lubrication around your eyes allow epidermis to dry up and get wrinkled and anew clinical avon dual dark circle corrector review dark circle corrector review thinner, however the amount of collagen and dark circle eye cream elastin in the neighborhood . just the actual skin and offers it a company and full appearance drops. So the appearance of the wrinkles and dark circles is more obvious.\nHalyoxl facilitates strengthening the blood circulatory system around the eyes and makes certain that hemoglobin doesn’t leak out and get deposited underneath the eyes. It is this deposition that gives a darker shade to the skin your eyes – which we commonly call as avon dual dark circle corrector review circles.\nIf you’re getting enough sleep, as well as haven’t attended a party in years what could be the associated with your dark circles? A few common causes include genetics, allergies and thinning skin associated with aging. It is really take appropriate measures about getting older, and also you can’t make positive changes to genetics. However, if have got allergies you can decrease anybody of your under eye circles by getting your allergies under eliminate.", "label": "No"}
{"text": "In-depth chemical substance and reaction data particularly useful for compound synthesis.\nReaxys includes three core chemistry information databases: Beilstein, Gmelin, and Patent Chemistry Database.\nThe reaxys database:\n- constitutes the merger of three databases: Crossfire Beilstein; CrossFire Gmelin and Patent Chemistry Database\n- supports research and fuels discovery by integrating reaction and substance data search with synthesis planning\n- provides access to relevant, actionable results; experimentally validated information\nSearch, analysis and workflow tools include:\n- synthesis planner to design optimum synthesis routes\n- multi-step reactions to identify precusor reactions underlying synthesis of target compounds\n- ability to generate structure query from names or phrases\n- search result filters by key properties; synthesis yield\n- results visualization\n- similarity search\n- transformation analysis", "label": "No"}
{"text": "Besh-Kol Lake, Dzungarian Alatau\nWalking to the lakes in the mountains of Almaty region and Dzungarian Alatau -\nLakes in the upper reaches of the Karasu River in the Dzungarian Alatau -\nBesh-Kol is a moraine alpine lake, located at an altitude of 3450 meters above sea level. The lake is located next to Lake Besh-Kol 1 (the first), all lakes are located next to each other in a common mountain valley, the area of the valley is 8.62 square kilometers and the perimeter is 12.63 kilometers. In this valley there are 5 large and 10 small lakes, from which the western sources of the Karasai River originate.\nHow to get there, visit -\nBesh-Kol Lake is located in the mountains of the Dzungarian Alatau, the upper reaches of the Karasai River, Almaty region, Eskeldinsky district, Kazakhstan.\nGPS coordinates: N44°58'43\" E79°45'04\"\nThe Besh-Kol Lake is located in the north-western part of the valley. The area of the lake is 85405 square meters, the perimeter of the lake is 1131 meters. The length of the lake from south to north is 350 meters, the greatest width in the central part of the lake is 320 meters.\n850 meters northwest of Besh-Kol, in the crest of the Dzungarian Alatau ridge, there is the Demekpe pass with a height of 3742 meters above sea level. 1.3 kilometers to the northeast in the hollow of the glacier is the moraine lake Besh-Kol 1 located at an altitude of 3457 meters above sea level. 1.4 kilometers to the southeast is the moraine lake Nizhny Karasai at an altitude of 3333 meters above sea level. A river flows from the southeastern part of the lake, which after 150 meters flows into the lower Besh-Kol lake, located at an altitude of 3448 meters above sea level.\nBesh-Kol Lake, Dzungarian Alatau, upper reaches of the Karasai River", "label": "No"}
{"text": "-Gingerol modulates spermatotoxicity associated with ulcerative colitis and benzo[a]pyrene exposure in BALB/c mice.\nJ Basic Clin Physiol Pharmacol. 2018 Jun 27 ;29(3):247-256. PMID: 29902912\nBabajide O Ajayi\nBACKGROUND: The deterioration of male reproductive health may represent an outcome of an active disease and environmental factors. The present study investigated the modulatory role of -gingerol in spermatotoxicity resulting from colitis and benzo[a]pyrene (B[a]P), an environmental and food-borne pollutant.\nMETHODS: Group I (control) mice received corn oil alone, while group II (-gingerol alone) mice orally received -gingerol alone at 100 mg/kg body weight. Group III [benzo[a]pyrene+dextran sulfate sodium (BDS) alone] mice were orally exposed to B[a]P at 125 mg/kg for 7 days followed by three cycles of 4% dextran sulfate sodium (DSS) in drinking water. A cycle consisted of seven consecutive days of exposure to DSS-treated water followed by 14 consecutive days of normal drinking water. Group IV (BDS+-gingerol) mice were orally treated daily with 100 mg/kg of -gingerol during exposure to B[a]P and DSS in the same manner as those of group III.\nRESULTS: -Gingerol significantly abrogated BDS-mediated increase in disease activity index and restored the colon wet weight, colon length and colon mass index to near normal when compared to BDS alone group. Moreover, -gingerol significantly prevented BDS-induced decreases in the daily sperm production (DSP), testicular sperm number (TSN), epididymal sperm number, sperm progressive motility and sperm membrane integrity when compared with the control. -Gingerol markedly increased the sperm antioxidant enzymes activities and decreased the sperm head, mid-piece and tail abnormalities as well as suppressed oxidative stress and inflammatory biomarkers in BDS-exposed mice.\nCONCLUSIONS: -Gingerol protected against spermatotoxicity in experimental model of interaction of colitis with environmental pollutant B[a]P.", "label": "No"}
{"text": "Targets & Outcomes\nFood Literacy Program (from Public Health: Food Literacy for Life)\nFood and Nutrition Knowledge\nFood Knowledge: To know the variety of foods within all food groups. To know where food comes from and what is in it. To make an informed decision on food choices including what is available locally.\nNutrition Knowledge: To understand the nutrients in food and how these can affect health and well being.\nFood and Nutrition Language: To understand commonly used words to describe characteristics of nutrition in food (e.g., high fibre, low sodium) and preparation of food (e.g., sauté, fold).\nFood Skills: To be able to prepare meals throughout the life span using basic skills like chopping, measuring, reading recipes, and being food safe.\nSelf-Efficacy & Confidence\nNutrition Literacy: To be able to distinguish between credible and false nutrition information. Knowing how to find reliable nutrition information and how to make sense of it (e.g., reading a food label).\nFood and Nutrition Self-Efficacy: To believe in one’s ability to apply food and nutrition-related knowledge to make healthy choices in a complex food environment.\nCooking Self-Efficacy: To have confidence in one’s ability to use cooking equipment and prepare tasty meals with available food.\nFood Attitude: To understand one’s attitude towards food and trying new foods. Having the desire to choose and prepare healthy and safe food to enjoy at all times.\nEcologic Factors (external)\nFood and other systems: To have an understanding of how the broader food system and society as a whole impacts an individual’s decisions about food and how an individual’s food choices impacts the broader food system (e.g., buying local food and the impact on the local farms or food industry).\nSocial Determinants of Health: To understand the social and environmental conditions (e.g., inadequate income and education) that can result in inequities in health status (e.g., adequate income) which can impact the capacity to make decisions about food and cooking.\nDietary Behaviour: To be able to apply knowledge and skills to make healthy food choices", "label": "No"}
{"text": "Vpliv lezik na razvoj kraških jam. Primer Velike doline, Škocjanske jame\nThere has been much less research studying original water courses along bedding planes in karst (bedding plane = the surface separating two successive layers of stratified rock of sediment origin; SSKJ II, p. 598) than that emphasizing the development of cave channels associated with the tectonic structure. The purpose of the research presented in the book was to expand scientific attention to the field where answers about the first beginnings of the formation of cave shafts and later karst caves might be expected. The author determines that studies on the formation of karst caves will need to consider the role of bedding planes to a greater extent since they proved to be much more than merely a more or less passive gap between two layers of rock. Despite the relatively large dimensions of karst caves, the initial processes occur at the microscopic level.\nThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.", "label": "No"}
{"text": "The Hawai‘i Department of Health reported 71 new cases of coronavirus Tuesday, raising the statewide total to 29,581. No new COVID-related deaths were reported.\nTuesday is the first day Hawai‘i has registered fewer than 100 new cases of the virus in nearly a week. The state’s two-week average is 94 new cases daily, with a test positivity rate of 1.6%.\nOne new case was identified on Kaua´i Tuesday, per DOH statistics. A DOH map, which tracks cases of the virus by district across all islands, can be accessed on the state’s COVID-19 informational website.\nThe island-by-island case count is as follows:\nA total of 1,979 individuals have been hospitalized as a result of COVID-19 infection since the pandemic began, while at least 462 people have died.\nMore than 611,000 doses of the vaccine had been administered across all islands as of Tuesday.", "label": "No"}
{"text": "Through the bumps of life we take on trauma patterns that persist in the body overtime. Releasing and resetting these patterns is effective in preventing chronic pain later in life or weakened functions in the body. Everyday stress, sports injuries, and unexpected accidents lower strength of the immune system making it harder for the body to heal if re-injured. Massage Therapy and Acupuncture have proven to increase circulation of blood and lymph, release soft tissue restrictions, reset neural pathways to reduce pain signals, and strengthen the immune system. These combined effects have lasting benefits, including long-term pain relief, increased mobility of the joints, and reduced tension from stress. Although it is hard to prioritize our health in times of financial strain this is often the most important time to maintain a sense of balance and well-being. Caring for your body, mind, and spirit is essential to coping with added stress efficiently. Listen to your body and know that there is always a place to receive the nurturing and restoration you need.\nFaiz Healing offers well rounded healthcare to serve patients needs. Patient care is the number one priority. If the therapies offered are unable to treat your concerns a referral will be given to someone who specializes in areas of need. Often times the best way to meet wellness goals and restore the bodies innate balance requires a multi-level approach to care. This involves a complementary medicine treatment plan that will be outlined for you through treatment consultation.", "label": "No"}
{"text": "Home > News > NGOs urge precautionary principle in use of nanomaterials\nJune 15th, 2007\nNGOs urge precautionary principle in use of nanomaterials\nIndustry is increasingly using nanotechnology in sectors such as healthcare (medicine), consumer products (food, electronics, cosmetics), information technology and the environment. However, major gaps remain concerning the exposure risks associated with nanomaterials.\nThe potential risks of nanotechnology include the risk to health of nanoparticles and materials as the nanoparticles can be inhaled, swallowed, absorbed through skin or injected into the body, whereas the behaviour of nanoparticles inside the body is not as yet known. As to environmental risks, the effects of free nanoparticles on the air or water are also unknown.\nNYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014\nIranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014\nIranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014\nStrengthening thin-film bonds with ultrafast data collection October 23rd, 2014\nPlastic nanoparticles also harm freshwater organisms October 18th, 2014\nHuman health, wealth require expanded marine science, experts say: In Rome, European experts publish a 'common vision' of priorities for marine research and action through 2020 October 9th, 2014\nCoating Nanotubes with Aluminum Oxide Lowers Risk of Lung Injury October 6th, 2014\nPEN Inc. Chairman Scott Rickert Announces Company Vision, Product Priorities and Management Team: Webcast Highlights the Launch of PEN October 3rd, 2014", "label": "No"}
{"text": "Best Peanuts in India are a popular food object this is loved around the arena. Those small, oval-shaped nuts are full of nutrition and feature a variety of uses in cooking and snacking.\nPeanuts are a good supply of crucial vitamins which include protein, fiber, healthful fat, vitamins, and minerals. They are also low in carbohydrates, making them a suitable meals for the ones on a low-carb or keto weight-reduction plan.\nPeanuts are used in a variety of dishes, together with stir-fries, curries, and baked items. They can also be roasted and eaten as a snack or used to make peanut butter, a famous unfold that is loved on toast, sandwiches, and utilized in recipes.\nBest 10 Benefits of Peanuts\n- Rich in nutrients: peanuts are a very good supply of critical nutrients inclusive of protein, fiber, healthy fat, nutrients, and minerals.\n- Accurate for coronary heart fitness: peanuts are rich in monounsaturated and polyunsaturated fats, which help reduce the danger of heart sicknesses by decreasing terrible cholesterol levels.\n- Allows manage blood sugar: peanuts are low in carbohydrates and high in fiber, which enables adjust blood sugar stages and save you spikes.\n- Promotes weight loss: peanuts are a low-calorie meals that may assist with weight reduction when consumed in moderation.\n- Accurate for mind fitness: peanuts comprise high ranges of diet e, that’s beneficial for brain fitness and cognitive characteristic.\n- Reduces irritation: the antioxidants and anti inflammatory homes in peanuts help reduce inflammation and oxidative stress inside the frame.\n- Strengthens bones: peanuts are rich in nutrients like magnesium, phosphorus, and potassium which can be essential for sturdy bones.\n- Boosts immune device: peanuts contain nutrition c, which helps improve the immune gadget and fight off infections.\n- Reduces cancer chance: peanuts are wealthy in polyphenols, which help prevent the growth of most cancers cells.\n- Desirable for pores and skin fitness: the vitamin e and healthful fats in peanuts help nourish the pores and skin and shield it towards solar damage and growing older.\nFurther to their delicious flavor and flexibility, peanuts have numerous health benefits. They’re known for promoting heart health, coping with blood sugar stages, decreasing infection, and boosting the immune gadget.\nTypical, peanuts are a scrumptious and nutritious food that can be enjoyed in a variety of methods. Whether or not as a snack or element in your preferred dish, peanuts provide both flavor and nutrients, making them a notable addition to any diet.", "label": "No"}
{"text": "Feel Tension Leave Your Body With Our Massage Services\nTraditional massage styles:\nMonday through Friday, 7AM till 4PM\n50 minutes for $70\n80 minutes for $100\nEvenings, Weekends and Holidays:\n50 minutes for $80\n80 minutes for $120\n50 minutes for $60\n80 minutes for $90\nRelax with a\nThe long gentle strokes of deep pressure to relieve tightness and soreness.\n25 minutes $70\n50 minutes $90\n80 minutes $150\nChoose from styles listed below.\nA combination of five different strokes including acupressure, skin rolling, Swedish strokes, and tapotement.\nWarm sticks of bamboo massage the body using Swedish strokes to push and roll bamboo along the body. The warmth of the bamboo allows massage into the deep layers of muscles thus relaxing muscles, increasing blood flow, and accelerating the healing process.\nEnjoy the warmth as hot volcanic river stones are massaged into the deep layers of muscles. This relaxes muscles, increases blood flow, and accelerates the healing process.\nA gentle massage which is intended to encourage natural circulation of the lymph from the body.\nImproves circulation, muscle tone, and lymph congestion thus improving the structure of the\nThis technique addresses the immobility of the muscle by stretching the fascia – a thin tissue that covers all the organs of the body including muscle – and equalizing muscle tension which can compress nerves and limit range of motion, posture and mobility can improve.\nFocusing on one body part to work out tightness and tension with deep circular friction and compressions.\nThe long gentle strokes of a Swedish massage using positioning more comfortable for the mother-to-be.\nEmploys the natural healing art of massaging the reflexes of the feet, hands, head, and ears. This increases the natural function of the corresponding glands and organs.\nJapanese for finger pressure, this technique applies pressure and circular movements along the meridians of the body using the therapists’ fingers and palms.\nAn energizing yet relaxing massage where the therapist uses her body to move you into a series of yoga-like poses, increasing muscle compression and joint mobilization.\nCOUPLES MASSAGE … $160\nCOUPLES MASSAGE CLASS … $200\nRomance or fun, your choice, as we teach you to give each other a massage. Both receive a full body massage.\nAromatherapy is a holistic healing treatment that uses natural plant extracts to promote health and well-being.\nA technique added to the end of any\nUses essential oils derived from plants, flowers, bark, and shrubs to promote a feeling of contentment, deep relaxation, openness, and sometimes a feeling of expansion. The life force of the plants combines their frequency with the body to create a greater healing process. Hot towels or steam applied on the back after all the oils are applied and massaged into the spine. The body releases toxins from the body and skin.\nMELISSA’S MASSAGE … $300\nThe ultimate 3-hour massage begins with a full body Aromatherapy massage adding Lymphatic strokes to flush toxins from the body. Hot stones are placed on the chakras of the body during a Balinese massage. Stones are replaced with Cupping while Shiatsu and NeuroMuscular strokes are applied. Lypossage strokes are then used to reduce cellulite. Then Hot bamboo sticks are used to massage the entire body followed by Reflexology of the hands, feet, and scalp. Cranial Sacral work aligns the body’s rhythm. The massage ends with Thai and Reiki.", "label": "No"}
{"text": "The phrase ‘detox drinks’ is quite common that everyone must have read or listened it. Have you ever wondered what they are, why are they so popular and why are they even needed? This article has got answers for all such questions.\nDetox drinks are the drinks made up of fruits, herbs, vegetables or other ingredients meant to flux out toxic substances from your body. They cleanse important body organs such as liver for their accurate functioning and are also referred to as cleansing drinks.\nHowever, this is not their only role. You will be astonished to know how much beneficial they are for our body. Whether you want to become more active, or lose fat, or maintain your body weight, or boost your immune system, your ‘Go-to’ drinks are the detox drinks.\nNEED FOR DETOX DRINKS\nThe human body inhales and consume harmful substances from the environment, but it has got special organs to eliminate them in the form of urine, feces, and sweat. However, the high amounts of industrialized pollutants (pesticides, heavy metals, gases) in today’s environment result in so high concentration of toxins that the natural secretion pathways of the human body are not proficient enough to eliminate them. Thus, they get accumulated in body cells and organs.\nNow, these harmful candidates can’t sit back silent. They obviously make the human body prone to illnesses. In severe cases, toxins can even become reasons for cancer, or reproductive, digestion or mental issues. Therefore, it is essential to remove the toxins from the body and detox drinks are the best suitable candidates.\nDETOX DRINKS – BENEFITS\nDetox drinks are beneficial in numerous ways. Regular use of detoxifying drinks is an easy trick to keep yourself healthy and away from common body problems. Try these and experience the following beautiful changes in your body:\n- Weight loss: Detox drinks speed up the body metabolism and help in shedding those extra kilos from your body. Such drinks can help in your body toning journey by speeding it up, but can only work if combined with regular exercise and a healthy diet.\n- Better digestion: Detox drinks provide hydration and essential nutrients your liver and free you from digestion issues.\n- Less inflammation: Inflammation is the result of free radicals produced in the body due to improper functioning of liver and intake of heavy meals. Thus, regular consumption of detoxifying drinks can reduce the swelling and inflammation in your body.\n- Clear skin: Harmful toxins in the body also lead to skin problems like dryness and wrinkles. Intake of detox drinks rich in vitamin C can give you a radiant and acne free skin, without aging signs.\n- High energy: Having detox drink once or twice a day makes you feel more energetic and alert in your day to day activities.\n- Relaxed mind: Several drinks containing lemon or mint freshen up both your body and mind and protect you from mood swings.\nDepending upon what you like, vegetables, herbs or fruits, you can make your own delicious cleansing drink or smoothie. There isn’t any special tip to prepare a detox drink; it is quite easy as you will know below. Find ahead a list of several detoxifying drinks that you must consume for healthy living.\nLemon based drinks:\nVitamin C is known to be the best agent for detoxification. A cheap and abundant source of vitamin C is lemon. It is rich in antioxidants and pectin fibers. It is the best detoxifying ingredient that burns the extra fat and flushes out toxins from the body. It can be used as a detox drink as follows:\n- Pour the fresh juice out of a lemon in a cup of warm water. Consume it after waking up in the morning. Addition of mint leaves will act as an icing on the cake.\n- Another early morning drink is lemon and honey in lukewarm water. Just add one tablespoon of honey in the above drink.\n- You can also make ginger lychee lemon drink. Ginger is good for reducing inflammation and enhancing metabolism while lychee adds a delicious flavor to the drink.\n- There is another lemon based drink that involves pure maple syrup (2 tablespoons), cayenne pepper, lemon (2 lemons), and water.\nWe regularly consume water throughout the day. Wouldn’t it be best to turn simple water into a detox drink? All you need to do is to take sliced detoxifying ingredients in the tumbler and fill it with water. Water can be refilled as it finishes and you can add fresh ingredients once the flavor starts diminishing.\n- Add 1 cinnamon stick and a sliced apple in a jar of water. The drink has the benefits of nutrients and antioxidants of apple.\n- Prepare a Slim down cleanser by adding sliced lemon, cucumber, and grapefruit in water. The drink exhibits delicious flavor of grapefruit and antioxidants of lemon. It works best for immune and cardiovascular systems, and eyes & skin problems.\n- An orange and blueberry drink made by wedge cut orange and few blueberries in water has a lot of antioxidants and fibers.\nYou can use strawberry, watermelon, pineapple, and banana as well for your detox water. For flavor, mint leaves can be added which aid in digestion as well.\nA tea can also be healthy and detoxifying! Yes, you read it right. There are a number of healthy teas rich in antioxidants. These are always advised to a person willing to lose weight. They are simple to prepare; just boil the ingredient tea leaves in water.\n- Dandelion root tea – Persons with stomach ulcers must avoid it.\n- Green tea – High content of antioxidants.\n- Fruit tea – chamomile tea with some berries, orange, ginger and mint leaves.\n- Turmeric tea –Rich source of antioxidants as well as anti-inflammatory ingredients.\nFruits are the storehouse of essential nutrients, minerals, fibers, and anti-oxidants. Every fruit has its own properties. Watermelon is good for blood pressure maintenance. Pineapple and strawberries are rich in vitamin C and hence anti-oxidants. Therefore, they aid in avoiding inflammation and getting glowing skin. Strawberries can reduce bloating and soreness in the muscles as well.\nPomegranate contains the goodness of antioxidants and hence, is good for your immune system. Whatever fruit you opt for, you are sure to get benefitted. Make sure you drink one cup of fruit juice every day.\nSome fruits become low in fibers when consumed as juice. Therefore, fruit smoothies are generally preferred. A fruit smoothie is prepared by simply blending the fruits. These can be:\n- Strawberry, apple and banana smoothie\n- Kiwi green smoothie\nJust like the fruit smoothies, vegetable smoothies are also rich in detoxifying agents, nutrients and vitamins. They are also prepared in the same way. Examples are:\n- Broccoli pineapple smoothie\n- Raspberry-Cauliflower smoothie\nApple cider drinks:\nUnpasteurized and unfiltered apple cider vinegar is a wonder drink for our body with multiple benefits. It contains antioxidants and anti-bacterial properties. You can consume it for the purpose of detoxification as well as weight loss.\nAn easily available summer drink, coconut water is also rich in antioxidants and helps our body in elimination of toxins.\nEven if you follow a healthy diet, you cannot avoid toxins considering the rise in environmental pollution. Their detoxification is highly essential for the smooth functioning of various body organs. The best detoxifying agents are the detoxifying drinks.\nBeing rich in antioxidants, the detox drinks not only eliminate toxic substances but also give our body numerous benefits like better digestion, weight loss, good sleep, relaxed mind, and others. However, it is a myth that detox drinks alone can make you fit; it is not possible. To get the most out of these drinks, combine them with a healthy diet and regular exercise!", "label": "No"}
{"text": "January 6, 2020\nWhat are the worst allergies in Dallas?\nAlong with fine dining, museums, and musical events, Dallas’s warmer climate means that many outdoor activities can be enjoyed year-round.\nUnfortunately, a warmer climate also means more allergy triggers. In fact, the Asthma and Allergy Foundation of America (AAFA) has included Dallas on its list of “The Most Challenging Places to Live With Spring Allergies.”\nWhether you just moved to Dallas from another state or have lived here for many years, it’s likely that you or someone you know has experienced severe allergy symptoms. So what is causing these allergy symptoms in Dallas, and what can you do about them?\nWhat kinds of allergies do you find in Dallas?\nAlthough Dallas does experience the four seasons, autumns and winters in Dallas are more mild than in cooler climates. This subtropical climate also means that many trees, grasses, and other plants can grow and bloom for a longer period of the year. This can make Dallas’ allergy season especially long and frustrating for those with allergies to these plants.\nDallas is home to many trees and grasses that create pollen for reproduction. While late spring and summer tend to be the worst months, many allergy-triggering plants and other organisms can be found year-round. A few of these plants and their strongest allergen-producing periods include:\n● Elm trees, which start to bloom and release pollen in February and March\n● Oak trees, which can release pollen well into May\n● Grasses, which bloom and release their pollen into late summer months\n● Ragweed, which causes the most hay fever in the country, triggers allergies in Dallas from mid-August through November, usually ending with the first frost\nOther trees that can cause allergy problems in the Dallas area include hickory,pecan, cedar elm, ash, and juniper.\nAnother cause of allergy aggravation is Texas’ windy weather. Many plants depend on the wind to carry their pollen for reproduction. This means that, in a breezy location like Texas, pollen can be spread throughout a wide area.\nFor example, spring winds from the south and southwest may spread pollen from Central to North Texas. This means that your allergies could be triggered by pollen from trees many miles away!\nSigns that you may have allergies\nWhile allergies often feel like a cold, the signs and symptoms of allergies in Dallas tend to start suddenly and last days or even weeks. In contrast, cold symptoms come on gradually and usually last for about a week.\nMost people with seasonal or environmental allergies in Dallas experience one or more of the following symptoms:\n● Runny, itchy, or stuffy nose\n● Scratchy or sore throat\n● Itchy, stinging, red, or watery eyes\n● Coughing and wheezing\n● Fatigue or difficulty sleeping,especially if you have trouble breathing or you’re up late sneezing\nHow to treat and control allergies in Dallas\nWhen was the last time you changed your air filters? You may have heard this advice before, though not necessarily about allergies. Besides keeping your home cleaner, healthier, and more efficient, frequently changing your air filters(at least every 6 months) can help control your allergies by keeping mold and dust under control, and filtering out allergens that may come in from the outside.\nOther ways to control allergies in your home:\n● Change clothes and wash your hair after spending extended time outside to remove pollen that may be sticking to your skin or clothing.\n● Keep jackets, shoes, and other items worn outside near the door; don’t bring them into the bedroom.\n● Use a HEPA filter in your home to help reduce or eliminate allergens and particles.\n● Use over-the-counter nasal spray sand antihistamines for as long as you are exposed to the allergens\n● Have cats or dogs? Pollen can collect in their fur, so bathe them regularly.\n● Avoid drying clothes outside.\nEven when venturing outside, there are ways to help control your allergy exposure:\n● If you know what your specific triggers are, track when they are strongest and limit your exposure. Apps and websites like Pollen.com can help with this.\n● Keep trees on your property trimmed to reduce their ability to release pollen.\n● Wear safety gloves and masks when working outside for lengthy periods.\n● Pollen is more active from 5am to 10am, so limit outdoor activities during these hours\nWhile Dallas may be a great place to live, it can also be a source of troublesome allergies. Unlike a cold or flu, allergies don’t necessarily go away in a few days or weeks. As long as you continue to be exposed to the allergen, you’re likely to keep having allergy symptoms.\nIf you're ready to get rid of allergies for good, visit us! We have clinics in the areas of, Arlington, Dallas (near Highland Park), Denton, Flower Mound, Fort Worth, Frisco, Grapevine/Southlake, Keller, Las Colinas, McKinney, Plano, Rockwall, and West Fort Worth (near Ridglea Country Club)!\nWe also have an amazing team that is ready to serve you and is highly trained in testing, diagnosing, and treating outdoor allergies! Our San Antonio team includes, Dr. Chris Thompson, sinus surgeon/sinus medical director, Dr. Eric J. Schmitt, allergist, Dr. Alvin J. Aubry, allergist, Dr. Bob Lanier, allergist, Megan Perkins, PA-C, Jofy Kuriakose, APRN, FNP-C, Amanda Thomas, PA-C, Jackie Wilson, APRN, FNP-C, Denise Peck, ARNP, Donna Yu, PA-C, Donnie Stone, MPAS, PA-C, and Kenzie Boen, PA-C!\nIf you’re looking to get long term relief from allergies, our allergy specialists at Aspire Allergy & Sinus can help you achieve long term relief from your allergies. Book your appointment online today and come see us!", "label": "No"}
{"text": "In October 1999, the world’s population nudged past the six billion mark, according to United Nations (UN) estimates. As this publication goes to press less than two years later, an additional 160 million plus individuals have been added to the tally—a number that is roughly equivalent to the current combined populations of France, Spain, and the UK. Even more striking is the fact that it took less than 40 years for the world’s population to double from three billion people in 1960. Can we expect the population to continue to grow at this pace? And, what are the implications of current and projected population growth for the world economy and the economies of individual countries and regions?", "label": "No"}
{"text": "Uncover hidden tea leaf meanings\nSimilar to angels birds featured in your tea leaf reading indicates that your spirit or soul is watching what you are doing.\nTo see a bird in general suggests that you are protected by your spirit guides. There are many different kinds of birds in the world so there are many meetings that can be interpreted from this tea leaf symbol.\nThe larger the bird, the more significant other meaning will be to your everyday life. To see a bird riding within your teacup is an indication of your future aspirations. This dream denotes moving yourself from one phase of life to another.\nBirds signal that times are about to change, and important events may be approaching. To dream of a birds nest indicates you are dealing with things on the horizon. If you see a birds nest near the handle indicates new beginnings are on their way - from a spiritual perspective. It is important to keep your own perspective to yourself! Sometimes this may prove to be difficult. This symbol can also symbolise your future aspirations.\nIn your teacup you may have:\n- Observed a flock of birds.\n- Seen many birds flying in your teacup.\n- Seen dots around the bird.\n- Could see a bird in a cage.\n- Observed a large or small bird.\nMeaning of birds positioned in your teacup:\nTop of teacup: traditionally, seeing a bird in your teacup near the top of the cup can be interpreted as simply a protection bubble around you. It also calls for certain actions from yourself. It is important to realise that we all need to release ourselves from a crossed conditions. The bird can be associated with new possibilities in life this symbol is important if you have faced difficult times in a relationship recently.\nMiddle of teacup: this symbol indicates that your relationship is being protected by your spirit guides. Perhaps somebody has been threatening the success of your relationship.\nBottom of the teacup: featured in the bottom position the bird symbolises dangerous situations. Positively, you are protected in these situations as a bird symbolises new beginnings. In addition this can indicate a relationship. This relationship has provided you with a much happier life.\nFlying birds: the birds can also signify breaking away from a situation. Have you been feeling bored at work and it is time for you to gain a new job?\nBirds in a circle: to see many birds in a circle means that you will have success in either a relationship connected with the heart or at work.\nIf two or more birds are seen as if flying towards the house, expect good news. If they are at rest, a stroke of luck is near.\nThe relative importance must be judged according to the size of the symbols whether the representation be a bird or any other symbol. For instance, if a small bird should be seen resting and a small horseshoe is by, good luck or good news, but not anything very great. If the birds seen flying are very small they would portend good news, but not quite unexpected, nor anything very great.\nIt is the business of the Seer to find resemblances formed by the tea-leaves and to consider the general character of the symbols in order to give an accurate judgment.\nIds of passage seem to inherit the gift of divination a remarkable degree. They assemble together at; appointed hour, and take their leave before the approach of winter, which they see will destroy the flies and insects; and it is extraordinary that they retia as soon as the sun brings forth into new life that which is necessary for their subsistence. They are clever enough to find out their old nests and habitations.\nNice on which side of the cup you may see the likeness of the bird or birds: if to the right, coming or, it is always a good sign of prosperous business, etc.\nFrom the handle on the left side, then look to your investments and your business. If you see it on the left side, you must beware of new propositions.\nBirds in general are good, but the interpretations vary with the species; also the dots and dashes must be taken into consideration. Remember dots are good dashes are obstacles. Also the positions must be studied.\nA flock of birds, change in circumstances or change of country.\nBy Flo Saul\nOct 20, 2012", "label": "No"}
{"text": "Mathematical Research Letters\nVolume 4 (1997)\nA presentation of the mapping of class groups\nPages: 735 – 739\nGiven a compact orientable surface, the mapping class group is shown to have a presentation so that the generators are the set of all Dehn twists and the relations are supported in subsurfaces homeomorphic to the one-holed torus or the four-holed sphere. It turns out that all the relations were discovered by Dehn in 1938.", "label": "No"}
{"text": "Human nature refers to the distinguishing characteristics—including ways of thinking, .... He defined human nature as a collection of epigenetic rules: the genetic ...\nthe psychological and social qualities that characterize humankind, especially in\ncontrast with other living things. 2. Sociology. the character of\nthe ways of thinking, feeling, and acting that are common to most people. 48 words to make in SCRABBLE with Q and no U » ...\nDefine human nature and get synonyms. What is human nature?\nThe general psychological characteristics, feelings, and behavioural traits of\nhumankind, regarded as shared by all\nAug 27, 2015", "label": "No"}
{"text": "This study focused on the prediction of a 22 km meandering channel migration of the Sabine River between the states of Texas and Louisiana. The meander characteristics of 12 bends, identified from seven orthophotos taken between 1974 and 2004, were acquired in a GIS environment. Based on that earlier years' data acquisition, channel prediction was performed for the two years 1996 and 2004 using least squares estimation and linear extrapolations, yielding a satisfactory agreement with the observations (the median predicted and observed migration rates were 3.1 and 3.6 [m/year], respectively). The best-predicted migration rate was found to be associated with the longest orthophoto-recorded interval. The study confirmed that channel migration is strongly correlated with bend curvature and that the maximum migration rate of the bend corresponded to a radius of curvature [bend radius (RC)/channel width (WC)] of 2.5. In tight bends of a smaller radius of curvature than 1.6, secondary flow scouring near the bend apex increases bend curvature. The stability index of the dimensionless bend radius was determined to be 2.45. Overall, this study proves the effectiveness of least squares estimation with historical orthophotography for characterization of meandering channel migration.\nAll Science Journal Classification (ASJC) codes\n- General Environmental Science\n- Management, Monitoring, Policy and Law", "label": "No"}
{"text": "Solvato-morphologically controlled photo-actuated hydrogels\nDunne, Aishling and Florea, Larisa and Diamond, Dermot (2014) Solvato-morphologically controlled photo-actuated hydrogels. In: RACI National Congress, 7-12 Dec 2014, Adelaide, Australia.\nFull text available as:\nIn recent years, photo-responsive hydrogels reported in the literature have been synthesised by co-polymerisation of N-isopropylacrylamide (NIPAAM) with spiropyran(SP) derivatives. This approach requires external protonation of the hydrogels in order to induce re-swelling, typically by immersing the hydrogel in strongly acidic environments1-3. Moreover, re-swelling times are long, typically up to several hours. These disadvantages have restricted the use of photo-actuated hydrogels to applications that employ single-use methods.\nRecently, we reported that the addition of acrylic acid copolymerised within the hydrogel provides an internal source of protons that allows photo-actuation in neutral pH environments4.\nThe polymerisation solvent has been shown to directly influence the morphology of the hydrogel, by producing porous hydrogels of different pore sizes5. This has an impact on the diffusion path length for water molecules moving in/out of the hydrogel matrix, thus improving the swelling and shrinking kinetics of the hydrogel6.\nIn this study photo-actuator hydrogels were generated using a N-isopropylacrylamide-co-acrylated spiropyran-co-acrylic acid (p(NIPAAM-co-SP-co-AA) copolymer, in a 100-1-5 mole ratio. Different ratios of organic solvent:water (tetrahydrofran(THF), dioxane and acetone) were used as the polymerisation solvent. Varying the volume ratio of the solvent mixtures, resulted in hydrogels with different pore sizes and therefore different extent of swelling/shrinking and actuation kinetics. For example, when THF:water (4:1 v:v) was used as polymerization solvent, a remarkable contraction in hydrogel size of up to 50% was obtained after four minutes of white light irradiation.\nOptimising these hydrogels by varying the polymerization solvent has resulted in faster and more reproducible shrinking and reswelling cycles.\nArchive Staff Only: edit this record", "label": "No"}
{"text": "About Nature Energy\nA leader in the green transition and a biogas pioneer\nToday, Nature Energy owns and operates 13 biogas plants located throughout Denmark, and owns and operates one plant in the Netherlands while more projects are in the pipeline.\nNature Energy’s biogas plants treated more than 4.7 million tonnes of biomass – waste from agriculture, industry and households – in 2022, converting it into more than 185 million m3 of green gas. That much biogas could be used to fuel almost 8,200 busses driving 30,000 miles per year, or to heat 160,000 homes. All of this is CO2 neutral as well as replacing fossil fuels.\nBiogas is circular economy at its best\nNature Energy is market leader in turning these many millon tonnes of biomass into green, CO2 neutral gas as effectively as possible. We collect and deliver biomass from businesses, agriculture and households and return the degassed biomass to the agriculture that recycles nutrients. This is circular economy at its best. At the same time, we always make sure that the surrounding community around our biogas plants remains as undisturbed as possible by transport and odours.\nNature Energy is already making a big difference in the green transition, but our ambitions are even bigger. That is why Nature Energy is investing intensively in research, including our own laboratory at our head office in Odense. The laboratory is a site for research into refining the technology so that we can extract even more energy from biomass and produce even better fertiliser for agriculture. The laboratory is also doing research in new biomasses for production of green, CO2 neutral energy in the future.\nNature Energy’s ambitions to contribute to the green transition together with farmers, businesses and people reaches beyond Denmark’s borders. Over the next few years, Nature Energy will be investing in new large biogas plants in other countries in Europe and North America.", "label": "No"}
{"text": "Americans’ obsession with weight control can lead them to embrace diet theories and convert too many of them into conventional wisdom. Alas, when medical researchers put widely accepted notions to scientific testing, they can evaporate faster than a rain drop on a hot summer sidewalk. That’s the potential fate of the idea that when people eat matters as much in weight control as what they consume.\nThis just isn’t so, according to “a rigorous one-year study in which people followed a low-calorie diet between the hours of 8 a.m. and 4 p.m. or consumed the same number of calories anytime during the day,” the New York Times reported, noting that so-called timed eating “has failed to find an effect.” The newspaper quoted Dr. Ethan Weiss, a diet researcher at the University of California, San Francisco, who reported this:\n“There is no benefit to eating in a narrow window … These results indicate that caloric intake restriction explained most of the beneficial effects seen with the time-restricted eating regimen.”\nAs the newspaper reported:\n“The study, published on [April 20] in the New England Journal of Medicine, was led by researchers at Southern Medical University in Guangzhou, China, and included 139 people with obesity. Women ate 1,200 to 1,500 calories a day, and men consumed 1,500 to 1,800 calories daily. To ensure compliance, participants were required to photograph every bit of food they ate and to keep food diaries. Both groups lost weight — an average of about 14 to 18 pounds — but there was no significant difference in the amounts of weight lost with either diet strategy. There also were no significant differences between the groups in measures of waist circumference, body fat and lean body mass. The scientists also found no differences in such risk factors as blood glucose levels, sensitivity to insulin, blood lipids, or blood pressure … The new study is not the first to test time-restricted eating, but previous studies often were smaller, of shorter duration and without control groups. That research tended to conclude that people lost weight by eating only during a limited period of time during the day.”\nThe latest study, though, has produced data so convincing that it even has persuaded author Weiss, whom the New York Times reported, “used to be a true believer in time-restricted eating and said that for seven years he had eaten only between noon and 8 p.m.” As the newspaper noted:\n“In an interview, Dr. Weiss recalled he could hardly believe the results. He asked the statisticians to analyze the data four times, until they told him further work wouldn’t change the results. ‘I was a devotee,’ he said. ‘This was a hard thing to accept.’”\nIt is relatively rare for diet and nutrition experts to subject theories and approaches about eating to testing with tough standards. The work has its limits, as does all diet research involving humans due to the many “confounding” factors abounding — all study subjects’ bodily functions can’t, for example, be easily monitored 24/7, they can’t include a starved or deprived control group, and all the myriad, complex factors that affect health and nutrition can’t be controlled.\nFurther, as experts noted in discussing the time-restricted eating study, individuals respond in different ways to weight-control efforts, the New York Times reported:\n“Dr. Christopher Gardner, director of nutrition studies at the Stanford Prevention Research Center, said he wouldn’t be surprised if time-restricted eating … worked on occasion. ‘Almost every type of diet out there works for some people,’ he said. ‘But the take-home supported by this new research is that when subjected to a properly designed and conducted study — scientific investigation — it is not any more helpful than simply reducing daily calorie intake for weight loss and health factors.’”\nIn my practice, I see the major harms that patients suffer while seeking medical services, and I have come to know all too well how they, and we all, struggle with the toll of excess weight. The federal Centers for Disease Control and Prevention estimates that 36% of adults and 17% of children in this country are obese, a chronic health bane that contributes to cancers, heart and lung diseases, diabetes, and more.\nBig Food — corporate interests raking in huge profits, whether from fast food and chain restaurants or the making and processing of foods or the selling of sugary sodas and other drinks — aren’t keeping your health or mine as their top priority. Their efforts may be helping to make us poorer and sicker. We, instead, all need to eat sensibly and well but in moderation, while also exercising regularly.\nThat may sound like simple common sense. But, speaking of rigorous research, this approach to diet and nutrition is supported, for example, by an $8-million, year-long study conducted at Stanford University with more than 600 test subjects. The New York Times reported of this study, funded by the National Institutes of Health, the Nutrition Group, and others, that its findings would help debunk some long-held notions about dieting — and some diet fads. Here’s the core of the newly published work’s key findings, according to the newspaper:\n“[P]eople who cut back on added sugar, refined grains and highly processed foods while concentrating on eating plenty of vegetables and whole foods — without worrying about counting calories or limiting portion sizes — lost significant amounts of weight over the course of a year. The strategy worked for people whether they followed diets that were mostly low in fat or mostly low in carbohydrates. And their success did not appear to be influenced by their genetics or their insulin-response to carbohydrates, a finding that casts doubt on the increasingly popular idea that different diets should be recommended to people based on their DNA makeup or on their tolerance for carbs or fat.”\nThat seems like sound guidance, and like the timed-eating information it is derived at least from research. We have much work to do to establish, in rigorous fashion, what works best for us with what we eat to stay healthy.", "label": "No"}
{"text": "Stretching Limits Muscle and Joint Strain – Stretching in the correct way can limit the strain on your muscles and joints. It will help your muscles stay flexible and toned. This will ultimately reduce the chance of injury after exercising.\nImportance of stretching after workout\n- Benefits of stretching. Some research shows that stretching doesn’t reduce muscle soreness after exercise, and other studies show that static stretching performed immediately before a sprint event may slightly worsen performance. Stretching can help improve flexibility, and, consequently, range of motion about your joints.\n- 1 What happens if I don’t stretch after working out?\n- 2 Should you stretch immediately after a workout?\n- 3 Is stretching important before and after a workout?\n- 4 Why stretching after workout is bad?\n- 5 What are 5 benefits of stretching?\n- 6 Can I exercise without stretching?\n- 7 When is stretching most effective?\n- 8 Does stretching after workout help muscle growth?\n- 9 Does stretching reduce strength?\n- 10 What is the benefits of stretching?\n- 11 What are 10 benefits of stretching?\n- 12 What are 5 benefits of stretching before exercise?\n- 13 Does stretching count as exercise?\n- 14 Does stretching make your muscles smaller?\n- 15 Does stretching tone your body?\nWhat happens if I don’t stretch after working out?\nYou might experience stiffness if you’re not stretching adequately. Muscles and tendons that aren’t stretched properly after exercise may be more susceptible to injury. If you already have an injury the Mayo Clinic advises adjusting your stretching routine.\nShould you stretch immediately after a workout?\nShould You Stretch After Exercise? This is a great time to stretch. ” Everyone is more flexible after exercise, because you’ve increased the circulation to those muscles and joints and you’ve been moving them,” Millar says. If you do static stretches, you’ll get the most benefit from them now.\nIs stretching important before and after a workout?\nWhy stretching is important Stretching keeps the muscles flexible, strong, and healthy, and we need that flexibility to maintain a range of motion in the joints. Without it, the muscles shorten and become tight. Then, when you call on the muscles for activity, they are weak and unable to extend all the way.\nWhy stretching after workout is bad?\nStretching keeps your muscles flexible and able to perform their entire range of motion. If you aren’t flexible enough, your muscles won’t extend to their full length, and you face a greater likelihood of muscle strain, joint pain and injury.\nWhat are 5 benefits of stretching?\nHere a few ways that stretching can benefit you and how to do it safely and effectively.\n- Stretching improves flexibility.\n- Stretching maintains mobility.\n- Stretching prevents injury.\n- Stretching improves posture.\n- Stretching improves sleep and eases anxiety.\nCan I exercise without stretching?\nYour Body Will Become More Vulnerable to Muscle Pain and Tightness. Without regular stretching, your body gets cold, and your muscles tighten up. Eventually, your muscles will pull on your joints and trigger significant pain and discomfort.\nWhen is stretching most effective?\nThe best time to stretch is after exercise, when your muscles are warm. True and false: It’s safer to stretch a warm muscle, and warm muscles are more relaxed and have greater range of motion. However, walking briskly or jogging for five minutes, until you break a light sweat, is a sufficient warm-up for stretching.\nDoes stretching after workout help muscle growth?\nIn addition to better range of motion, post-workout stretching can actually help prime your body for growth and enable gains. Every muscle is your body is surrounded by fascia, which is a connective tissue that hugs your muscles to stabilize and keep them in place.\nDoes stretching reduce strength?\nAlthough most studies have found acute decreases in strength following stretching, and that such decreases seem to be more prominent the longer the stretching protocol, the number of exercises and sets, and the duration of each set have, in general, exceeded the ranges normally recommended in the literature.\nWhat is the benefits of stretching?\nHowever, research has shown that stretching can help improve flexibility, and, consequently, the range of motion of your joints. Better flexibility may: Improve your performance in physical activities. Decrease your risk of injuries.\nWhat are 10 benefits of stretching?\n- Decreases muscle stiffness and increases range of motion.\n- May reduce your risk of injury.\n- Helps relieve post-exercise aches and pains.\n- Improves posture.\n- Helps reduce or manage stress.\n- Reduces muscular tension and enhances muscular relaxation.\n- Improves mechanical efficiency and overall functional performance.\nWhat are 5 benefits of stretching before exercise?\nHere are five benefits that stretching has.\n- Stretching can improve posture. Tight muscles can cause poor posture.\n- Stretching can improve range of motion and prevents loss of range of motion.\n- Stretching can decrease back pain.\n- Stretching can help prevent injury.\n- Stretching can decrease muscle soreness.\nDoes stretching count as exercise?\nStretching can definitely help you become a fitter individual. As we’ve previously said, stretching definitely counts as a form of exercising and it can, 100 percent, help you become more fit than you currently are and nudge you in the direction of a healthier lifestyle.\nDoes stretching make your muscles smaller?\nIn a recent study conducted at the University of Nevada, Las Vegas, athletes generated less force from their leg muscles after static stretching than they did after not stretching at all. Other studies have found that this stretching decreases muscle strength by as much as 30 percent.\nDoes stretching tone your body?\nYes, stretching can help you tone-up assuming you follow your stretches with strengthening exercises. When a muscle is stretched (and held for 30 seconds) two basic things happen in that muscle. One is the muscle starts to relax and the second is the muscle increases in length (elongates).", "label": "No"}
{"text": "Date Presented 04/02/2022\nThe Child Assessment of Function Eating (CAFE) was designed to provide a comprehensive feeding assessment, with all major components (self-feeding, self-drinking, mealtime behavior, oral-motor skills, sensory food preferences, nutritional intake) in one assessment. This poster will present the normative data obtained from 63 children ages 3-7 years who were evaluated with the CAFE. Data collection included a 3-day food diary, the CAFE form, and a food preference checklist.\nPrimary Author and Speaker: Donna Wooster\nContributing Authors: Breana Pitts, Shelby Ready, Chandon Hines, Caroline Rentschler, Tori Schroeder\nPURPOSE: The purpose of this research is to share the normative sample data obtained on the new Child Assessment of Functional Eating (C.A.F.E.) tool. Feeding and eating is an important self-care skill routine accomplished in young children that is life sustaining. A child’s ability to eat is critical to overall health and wellness, and the daily routines surrounding feeding and eating play an integral role in emotional development, social interaction, and cultural understanding. As many as 50% of parents indicate that typically developing infants and young children may have a feeding problem (Miller, 2009) and up to 80% of children with known developmental delays have feeding difficulties (Phalen, 2013). Parental and pediatrician concerns lead to referrals for feeding evaluations to make sure we address the needs of the child as early as possible to minimize potential growth failures or nutritional deficiencies. Occupational therapy practitioners are uniquely positioned to assess and treat difficulties associated with feeding because of our holistic perspective of recognizing and assessing not only the physiological factors but also the psychosocial, cultural, and environmental factors involved with these aspects of daily performance (American Occupational Therapy Association, 2017). Occupational Therapists have a wide variety of feeding assessment tools available, but most are focused on assessment of only one aspect of feeding. Each child’s feeding issues vary due to their diagnosis, symptoms, behaviors, and preferences. Children often have deficits in multiple aspects related to feeding (motor, sensory, environmental, cognitive, etc.) that must be identified to determine the appropriate plan of care.\nDESIGN: This research was designed to obtain normative sample scores on the C.A.F.E. The Child Assessment of Functional Eating (C.A.F.E.) was designed to measure mealtime feeding deficits in children, 3 to 7 years old, with ease and sensitivity to change. The C.A.F.E. consists of six subtests that include self-feeding, self-drinking, mealtime behaviors, oral motor skills, sensory food preferences, and nutritional food intake. Each subtest is scored individually and then an overall total scores is calculated. The design allows OTs to later administer the entire tool again or to administer just selected subtests as a way to show progress and developmental progression with age.\nMETHOD: Children with typical development and no known feeding disorders between the ages of 3 and 7 were recruited for participation on this research. IRB approval was obtained. Written parent consent was obtain. Child assent was obtained for each participant.\nRESULTS: This research presents the scores on the C.A.F.E. from 63 typically developing children, 3 to 7 years of age. Results are presented per each of the five age groups and on each of the six subtests, as well as, the overall total score.\nCONCLUSION: The results indicate that the C.A.F.E was able to show a clear age progression normative score on five out of six subtests. The five subtests present with data to promote the use of this tool as a way to determine feeding delays in children between the ages of 3 and 7 years. The C.A.F.E. is an easy to administer standard assessment of feeding that can be utilized to determine feeding deficits and allows OTs to prioritizing feeding needs and design a customized evidence-based feeding intervention plan to address these needs. The C.A.F.E. provides a standardized assessment to analyze feeding abilities comprehensively.\nAmerican Occupational Therapy Association [AOTA]. (2017). The practice of occupational therapy in feeding, eating, and swallowing. American Journal of Occupational Therapy, 71, 7112410015. https://doi.org/10.5014/ajot.2017.716S04\nBorowitz, K. & Borowitcz. S. (2018) Feeding and problems in infants and children: Assessment and etiology. Pediatric Clinical North America, 65, 59-72.\nMiller, C. (2009). Updates on pediatric feeding and swallowing problems. Current Opinions Otolaryngical Head Neck Surgery, 17, 1940197.\nPhalen, J. (2013). Managing feeding problems and feeding disorders. Pediatric Review, 34, 549-557.", "label": "No"}
{"text": "Wondering if the damage on your property might be the result of termites? The pest control experts at Griffin Pest Solutions are here to help!\nUnderstanding the telltale signs of termite damage is crucial for Michigan homeowners and property managers. Termites are silent invaders, and their destructive habits can go unnoticed until significant damage has occurred. Below, we’ll explore the various indicators of termite infestations and what termite damage looks like. By becoming familiar with these signs, you can take proactive measures to protect your home and assets from the costly consequences of termite infestations.\nHow to Identify Termite Damaged Wood\nTermite damage can vary in appearance depending on the type of termite and the extent of the infestation. Here are some common signs and what termite damage may look like:\n- Wood Damage: Termites primarily feed on wood, and one of the most common signs of termites is damaged or hollowed-out wood. You may notice that wooden structures, such as beams, furniture, or flooring, appear damaged or weakened. Termites often consume wood from the inside, leaving a thin outer layer intact, which can make the damage hard to detect.\n- Mud Tubes: Subterranean termites, which are common in many regions, including the United States, build mud tubes. These pencil-sized, mud-colored tubes run along the surface of walls, foundations, or other structures and provide protection for the termites as they move between their nest and their food source.\n- Swarmers: Termite swarmers, also known as “alates” or “winged termites,” are reproductive termites that emerge from mature colonies to establish new ones. Seeing swarmers indoors or finding discarded wings can be an indication of a nearby termite colony.\n- Frass or Droppings: Drywood termites push out their feces, which can look like tiny pellets or sawdust. Finding these pellets or “frass” near termite entry points is a sign of their presence.\n- Blisters in Wood: Termites may create small blisters or bulges on the surface of painted or finished wood. These blisters can indicate termite activity beneath the surface.\n- Damaged Paper or Cardboard: Termites are known to feed on paper and cardboard, so you might find damaged documents, books, or cardboard boxes in areas where termites are present.\n- Tunnels or Galleries: Subterranean termites create tunnels or galleries within wood, often lined with mud, which can be visible if the wood is broken open.\nIt’s important to note that termite damage can often go unnoticed until it becomes extensive. Regular termite inspections by a pest control professional are crucial for early detection and prevention of significant damage. If you suspect termite activity in your home, it’s advisable to consult with a pest control expert for a thorough inspection and appropriate treatment.\nNeed An Estimate for Termite Control?\nThe Beginning Signs of Termite Damage\nEarly detection of termite activity is crucial for effective pest management and minimizing potential damage. Here are a few things to keep an eye out for:\n- Discarded Wings: Termite swarmers, the reproductive members of the colony, may shed their wings after swarming to establish new colonies. Finding discarded wings around windowsills, doors, or in spider webs can indicate nearby termite activity.\n- Blistering or Bubbling Paint: Termites can create small blisters or bulges on painted or finished wood surfaces. These imperfections can be early indicators of termite activity beneath the surface.\n- Small Holes in Drywall: Termite damage may lead to small holes or punctures in drywall, and these areas may appear like pinpricks.\n- Sagging or Buckling Floors: If your wooden floors begin to sag or buckle, it may be a sign of termite damage weakening the structural support.\n- Clicking Sounds: Some termite species make clicking or rattling sounds when disturbed. You may hear these noises if you tap on or disturb a termite-infested area.\nHow to Prevent Termite Damage\nPreventing termite damage is often more cost-effective and less troublesome than dealing with infestations after they’ve occurred. Here are essential steps to help protect your property from termite damage:\n- Regular Inspections: Schedule routine termite inspections by a pest control professional. Professionals can detect early signs of termite activity and recommend necessary preventive measures.\n- Termite Barriers: Install physical termite barriers, such as termite shields or chemical barriers, around the foundation of your home. These barriers create a deterrent that can help keep termites at bay.\n- Foundation Maintenance: Keep your home’s foundation clear of soil and vegetation. Ensure that the ground slopes away from the foundation to prevent water from pooling near the structure, as excess moisture attracts termites.\n- Proper Ventilation: Maintain good ventilation in crawl spaces and basements to reduce humidity levels, as termites are drawn to moisture. Consider using dehumidifiers if necessary.\n- Wood Selection: When building or renovating, use termite-resistant wood, such as pressure-treated lumber. This wood is less appealing to termites and can help reduce the risk of infestation.\n- Regular Maintenance: Keep your property well-maintained, addressing issues like leaky pipes, damaged roofs, and faulty gutters promptly. Fixing these problems reduces potential entry points for termites.\n- Remove Termite Food Sources: Discourage termites by storing firewood, lumber, and wood debris away from your home. Additionally, clear away dead or decaying trees and stumps that can attract termites.\n- Close Gaps and Cracks: Seal gaps or cracks in your home’s exterior, such as around windows, doors, and utility lines. Termites can exploit even tiny openings to gain access.\n- Professional Pest Control: Consider ongoing termite control services from experts like Griffin Pest Solutions to create a protective barrier against termite infestations. Regular treatments and monitoring can be a proactive defense.\nHow to Fix Termite Damage\nFixing termite damage may require a combination of DIY efforts and professional assistance.\nIf your property has termite damage, it’s understandable that you would want to get that fixed right away. But before you begin tackling home repairs, you need to eliminate the existing infestation and establish a plan to prevent future ones as well. The best way to do this is by reaching out to your local pest control experts. It’s important to act promptly in order to prevent further deterioration of your home’s structure.\nAre Termites Damaging Your Property? Give Us a Call!\nIf you suspect termite damage or have spotted early signs of infestation, don’t wait. Griffin Pest Solutions is your trusted partner in termite detection, removal, and prevention.\nOur termite control experts will be able to identify the type of damage you’re dealing with, find your termites, wipe them out, and make sure they never come back. When you choose Griffin for your termite pest control, you get service that lasts – no ifs, ants, or bugs!\nStill have questions? Want to schedule an appointment? Contact us today.Back to Termite Exterminators – Control – Removal", "label": "No"}
{"text": "How ridiculous to suppose that tlie bile is a \"levitra\" natural cathartic. If the strangulation is of recent occurrence, and purchase the sac free from inflammation and of normal appearance, an effort may be made to secure its return by gentle taxis into the cavity of the abdomen. AA'e might conjecture that such persons would be likely to transmit to their oflfspi ing some degree of taint, seeing viagra that the taint is still in activity in their own bodies. Once typical symptoms have appeared, there is too often a delay in diagnosing and rezept initiating treatment. These are given as general indications dosage without REGIONAL OR CANOPY INCANDESCENT LIGHT When we are desirous of affecting a focal point of pathology it is often very advantageous to invoke the aid afforded by the physiological stimulation of adjacent tissues and in these cases the tungsten lamps are used in groups or clusters, with or without reflectors as desired. Those sick of typhus should be treated in large airy and the beds should be at least six feet apart: 10. Since autolysis usual method of killing by heat recommendations must alter certain represent the full immunizing properties of the substitute oils for the physiological salt solution previously used in making bacterial vaccines. The most frequent histological type is fibrosarcoma and it is also The treatment \"vs\" is free excision of the growth and mediate and rapidly extending local recurrences are The Loomis Sanatorium for the treatment of tuberculosis has recently issued a very handsome monograph in commemoration of the twenty-fifth anniversary of its founding. Even nodosities rarely kaufen or never occur now-adays in consequence of improved methods in technique and in the preparation of the drugs used.\nIn - cases have been reported from all the Euro Australia, Japan, Hawaii, South, Central and North America. None of these has been proved to be the cause to transmit the disease to dogs, rabbits and other animals, by inoculation has still to be proved that the blood, black vomit, or alvine discharges contain the infective agent of comprar yellow fever.\nDietch and others point de out as a diagnostic sign the accentuation of the rash on the anterior surface of the elbows when the shoulder is compressed by a tourniquet for a minute.\nEleven Hundred and Sixty-four Illustrations, Five Hundred and Fifteen sizes Printed in Colors.\nWith - every slight cold in a child of tender years should be taken seriously and properly attended to. His comment can online be easily paraphrased for physicians.\nDuring pregnancy it was observed that some diseases were retarded, for example \"coupons\" tuberculosis and epithelioma uteri.\nPractically no studies had been offer made for the purpose of ascertaining what efifect such remedies produced upon the blood and body fluids. Hydrotherapy may be practised with cheap good results in some cases. An acquired immunity, on the other hand, is established after an animal has passed through a single attack of a certain disease and lasts for a certain time (immunity after recovery) (mg).\nThe opening is often very difficult or impossible to find or only 10mg evident after injection from the main vascular and the rapidity with which it flows. The editor has collaborated in each of these sections 20 as a stomatologist. There was no efiiect noted on the blood pressure by the presence or absence of sugar and blood sugar of diabetic patients living on diets simifar to those recommended by Newburgh and taking Marsh, that is, a low protein, low carbohydrate and high fat diet.\nIn alopecia totalis and alopecia universalis tbe prognosis is bad, but there are numerous instances of trial comjilete and spontaneous restoration of hair. A simple classification will perhaps cialis best demonstrate to the general practitioner, as well as the specialist in either of the two fields, that no one branch of medicine can be independent. However, there are cases of excessive secretion in which hyperchlorhydria is not dependent on spasm (discount). IS DISSEMINATED SCLEROSIS AN ACUTE INFECTION? The aetiology of insular or disseminated sclerosis has long been as obscure as the symptoms of that protean disease are apt to be ohne perplexing. Thickening of the skin on the elboAvs and knees is not uncommon, but discrete nodules here are rare: for. The obstetrician should be careful to write a full history and make complete and regular notes of visits and examinations during pregnancy, including the results of pelvimetry and the diagnosis of position, which should be sent to the hospital as soon as the patient went into labor: and. And when her womb was opened the next day, a living child was found; on March drowning four days, was found to bear a living Cangiamila relates many cases of this kind, some of them so extraordinary, that they hardly When the mother dies during the earlier period of pregnancy, before the end of the third month of gestation, great care must be exercised in the operation, so that the tender fetus may not be exposed to additional danger before it can be\"With the fruits of the earher periods it is always a case of mortis articulus, nay, in most instances death has overtaken them before they may be born: vardenafil.", "label": "No"}
{"text": "top quality with a delivery time of 1 working day,\nfrom a dog food professional (no grocery quality)!\nIf you want to send us a question about this product, simply complete all the fields marked * and click \"Send\".\nDelivery weight: 2.5 kg\nN&D Chicken & Pomegranate fresh chicken-vegetable complete dog food is a fresh meat-based, very meat-rich (70%) and completely grain-free new generation complete food. It does not contain cheap plant protein concentrates, nor plant protein from legumes such as peas, lentils or soybeans, nor does it add any chemical antioxidants or preservatives. Its high meat content means more protein (34%) and less carbohydrates and most importantly, the protein is high quality animal protein (> 98%).", "label": "No"}
{"text": "AUSTIN, Texas, June 15 /PRNewswire/ — Summer is the season of outdoor activities – running, swimming, soccer and enjoying everything the outdoors has to offer. Coincidentally, it is also ice-cream-truck-and-cotton-candy-at-the-fair season.\nTo view the multimedia assets associated with this release, please click: http://multivu.prnewswire.com/mnr/texasbeef/44074/\nWith the Centers for Disease Control and Prevention (CDC) reporting that 28 percent of Texans are obese and that childhood obesity rates have tripled in the last 30 years, this summer junk-food-jubilee can be a dangerous time for your family’s health. Now is the time for parents to mold a healthy diet for the whole family.\nRegistered Dietician Martha Cortez McHenry advises parents to create a summer menu based on a protein-rich diet. Current research suggests that packing meals with high-quality, lean proteins may be the first step in maintaining a healthy weight. Filling plates with fruits and vegetables, low- and non-fat dairy products, whole grains and lean protein supplies important vitamins and minerals the body needs. Lean beef is a familiar, high-quality lean protein that kids enjoy. An added bonus: it contains 10 essential nutrients and is the number one food source of B12, zinc and, most importantly, protein, McHenry says.\n“Protein can help all of us maintain a healthy weight, build muscle and fuel physical activity, all of which play an important role in a healthful lifestyle,” McHenry said. “It is especially important for children to have a protein-rich diet, as their bodies are developing; and they need anti-bodies, which consist of protein, to bounce back from injury and illness.”\nHigh-quality, complete proteins like lean beef provide the right amounts of essential amino acids, or “building blocks,” the body needs to grow and maintain muscle; so everyday function depends on sufficient protein intake, McHenry says. Lean proteins also provide the energy needed to maintain the level of physical activity necessary for maintaining weight.\nIncluding protein foods in your family’s diet will also help keep them full because it has more staying power than carbohydrates and fats, according to a 2007 study by the Journal of Nutrition.\nWith these proven benefits, McHenry is working to dispel the misconception that protein foods, like beef, are unhealthy and full of fat. In reality, a 3-ounce serving of lean beef has, on average, only one gram more of saturated fat than a skinless chicken breast. In fact, 29 cuts of beef meet the federal standards for “lean,” and all of these cuts weigh in at 175 calories or less with fewer than 10 grams of fat for a 3-ounce serving. In addition, more than 50 percent of beef’s fats are monounsaturated — the same heart healthy fats found in olive oil.\nTo start building a healthy family lifestyle, keep these protein tips in mind:\n— When planning a day trip, pack lunches made with peanut butter, tuna (in water) and string cheese.\n— Stock your pantry with snacks like nuts, whole grain crackers and beef jerky.\n— When shopping for dinner items, choose the leanest cuts of beef with “loin” or “round” in the name; and choose ground beef that is at least 90 percent lean.\n— Use low-fat cooking methods, such as broiling, roasting or the summer favorite, grilling.\n— Serve the recommended 3-ounce portion size for meats — the size of a deck of cards or a computer mouse.\nFor beef recipes and more nutritional facts, visit http://www.mejorprovecho.com.\nSOURCE Texas Beef Council", "label": "No"}
{"text": "Libido or sexual desire can decrease due to various things, from stress to certain medical conditions. If you or your partner often experience it, there are several types of exercise to increase libido and increase satisfaction during sex.\nEveryone's libido level can be different. However, there are several conditions that can cause a person's sexual desire to decrease, ranging from problems with a partner, severe stress, fatigue, pregnancy, menopause, to certain health problems, such as diabetes, hormonal disorders, and cancer.\nBenefits of Exercise to Increase Libido\nExercise can nourish the body, both physically and mentally, which in turn can increase your libido or sexual desire. Here are some of the benefits of exercise associated with increasing libido:\n1. Increase sexual satisfaction\nExercise is one of the best activities to do regularly to increase stamina, including libido, and increase sexual satisfaction. With strong stamina, the duration of your sexual relationship with your partner can last longer.\nIn addition, exercising can also build muscles that play an important role in sexual intercourse, such as the abdominal muscles, pelvic floor muscles, and muscles around the thighs, legs, and intimate organs. With better health, your body will also find it easier to reach orgasm.\n2. Reduce stress\nExercise is a healthy way to manage stress. This is because physical activity can stimulate the production of endorphins, which are natural stress and pain relieving hormones, so you can feel happier. When you are happy, your libido can also increase.\n3. Increase self-confidence\nSexual desire is also influenced by how you view yourself. There are studies that say that regular exercise can make a person view himself more positively, so that self-esteem and self-confidence will increase. That way, sexual desire can also increase.\n4. Improve circulation and blood flow\nWhen exercising, the heart will pump blood faster and more, so that blood flow throughout the body will be smoother, including to the intimate organs.\nIn men, smooth blood circulation is useful for smoothing the erection process and making it last longer. While in women, it can stimulate the vagina to produce natural lubricating fluids more smoothly.\nTypes of Exercise to Increase Libido\nBasically, all types of exercise are good to do, but there are several types of exercise that are more effective at increasing libido, including:\n1. Kegel Exercises\nKegel exercises are one of the sports that are beneficial for sexual performance, including to increase libido. This exercise allows blood to flow more smoothly to the intimate organs and strengthens the pelvic floor muscles.\nIn men, it can then prevent premature ejaculation. While for women, Kegel exercises can help increase the production of vaginal lubricating fluid, make vaginal muscles tighter, and facilitate orgasm.\nSquat useful for toning the muscles of the lower body, such as the legs and buttocks. In addition, this exercise can also facilitate blood flow to the intimate organs. Therefore, doing squats can help increase your libido.\nYou can also make yoga an exercise option to increase libido. Doing yoga regularly can help increase stamina, calm down, reduce stress levels, and improve mood. That way, your sexual desire can also increase.\nThis exercise can increase blood flow throughout the body, improve sleep quality, reduce stress, and improve mood. Swimming is also good for training the muscles and joints of the body to be stronger and increase stamina, so that sexual arousal can also be more easily awakened.\n5. Cardio workout\nDoing a variety of cardio exercises can help improve blood flow and maintain an ideal body weight. For men, this is useful for making erections last longer. As for women, cardio exercise can help achieve orgasm more easily.\n6. Strength training\nStrength training is useful for training and toning the muscles of the body, so that your body can look more athletic and proportional. In addition to making you more confident, a beautiful body shape can also make your partner more interested in having sex.\nSo that the benefits of exercise to increase libido can be maximized, you or your partner need to do it regularly. The ideal recommended time for exercise is 20−30 minutes every day or at least 3−5 times a week.\nTips to Increase Libido and Sexual Satisfaction\nTo support the effectiveness of the exercise, you can also increase sexual arousal and make sexual intercourse more enjoyable in several ways, including warming up before sex or foreplay longer.\nyou can start foreplay by giving a massage or gentle touch on your partner's sensitive parts. Then, also give him caresses and kisses, so that the atmosphere becomes more intimate.\nTo avoid boredom, you and your partner can change the atmosphere during sex, for example by taking a bath together before having sex or trying to have sex in the bathroom.\nDon't forget to eat libido-enhancing foods, get enough rest, and manage stress well, so that your sexual life with your partner remains harmonious.\nIf you still have questions regarding the benefits and types of exercise to increase libido or experience problems with the quality and satisfaction of sexual relations, do not hesitate to consult a doctor.", "label": "No"}
{"text": "Are you frustrated doing exercises and yet not losing weight? Is cardio included in your workout regime? Let me tell you more about it.\nWhat is cardio?\nYou might have heard this word “cardio” most probably in gyms and by the gym trainers. Cardio is generally a short form for cardiovascular exercises. Any kind of exercise that raises your heart beat is called cardio. Doing cardio helps to burn calories, keeps up your heart rate, improves your metabolism and is genuinely good for muscles.\nOur heart is also a muscle and requires regular exercise. Cardio increases the efficiency of heart to pump blood and provide oxygen and nutrients to every part of our body. Cardio exercises are intense and increases your heart rate 50% than normal. By doing so, it keeps your heart healthy. People should perform at least 150 minutes of moderate intensity cardiovascular exercises every week.\nCardio exercises are also called aerobic exercises. Running, cycling, swimming, brisk walking, dancing, and resistance training are also cardio exercises.\nWhat are the major types of aerobics/cardiovascular exercises?\nCardiovascular exercise is categorized into three types:\nHigh-impact cardiovascular exercises are generally called weight-bearing exercises. Weight-bearing involves keeping your feet off the ground at some moment during the exercise. You support your own body weight with your limbs against the force of gravity. Exercise like high-impact aerobic dance called zumba, jumping ropes, and advanced resistance/strength training.\nAn exercise in which one of your feet remains on the ground during the whole session. But let me tell you that there is an difference between low-intensity cardio and low-impact cardio, as many low-impact activities is sometimes of high intensity. Low-impact exercises are excellent for improving the strength of bones and conditioning the heart and lungs.\nNo-Impact cardio are non-weight-bearing exercises usually performed in water. Exercise performed in water like swimming and water aerobics are called no-impact cardio because being submerged in water reduces the pull of gravity over the body. No-Impact cardio exercises are recommended to people who have joint problems, chronic pain, arthritis, and who are recovering from injury.\nImportant facts about cardio\nCardio exercise improves brain health and can also reduce the risk of dementia. Cardio exercises guards your brain from Alzheimer’s disorder and improves memory and thinking ability.\nIt protects and strengthens the joints. Cardio exercise slows the rate of osteoporosis, reduces the chance of fractures and maintains the range of motion of joints.\nCardio exercises increase blood circulation and hence succors us to have a clearer and healthier skin.\nIncluding cardio exercise to your regular workout regime helps muscle to adapt the pressure and workload and makes the regular exercise bit easier.\nAs cardio helps to circulate more blood, it prevents from developing diabetes, certain cancer, and cardiovascular diseases.\nWhen cardio exercise is followed with a healthy nutrition plan, it helps to lose weight and keeps the body active.\nKeeping your body active reduces blood sugar levels, keeps the vital organs stress free and reduces the chance of evolving type 2-diabetes.\nCardiovascular exercise aids you to have a good sleep. Individuals who suffer from extreme sleep issue like insomnia, cardiovascular exercises with a sleep hygiene education is a perfect education.\nCardiovascular exercise increases the immunoglobulins that are present in the blood. In lay man’s language, aerobic exercise strengthens the immune system. Aerobic exercise when performed, produces endorphins; a hormone that reduces stress and pain.\nIndividuals suffering from depression, initially in one or two session of 30 minutes are enough to improve their condition. Cardiovascular exercise helps to reduce asthma. It helps to reduce the frequency and severity of the asthma attacks.\nMyths about Cardio\nMYTH 1: You should always run before you lift weights. You can get good results by running on treadmill but there is no point in doing so, as you invest all your weightlifting energy by running. But, hey! Best time to do cardio is whenever you feel is the right time. Hitting treadmill for slow jogging or bicycle is a good idea to warm up the body and to get sweating before lifting weights.\nMYTH 2: Always perform cardio on a fasted stomach. It’s a myth! I will tell you why doing your cardio with something in your stomach is way better than doing fasted cardio. There are no results of breaking down of triglyceraldyhides into fatty acids for fuel on a fasted cardio. But there are studies that say it is the best way to lose fat.\nSecond reason says that it is too hard on your body. It is generally done in the morning when you wake up. Many people when they wake up they are in a catabolic state. Generally means that protein is used as fuel rather than fats. To avoid that having protein before cardio can be better.\nSince you are already in a catabolic state, feeding the muscles with protein will not cause any harm. It will help you to maintain the muscle protein synthesis during cardio. 10 to 20 grams of protein will be relatively enough before cardio.\nMYTH 3: Doing more cardio is better for you. It is a myth because doing lots of cardio may burn your muscles which eventually affect your metabolism. It can weaken your immune system. Doing too much of cardio releases excess cortisol (a stress hormone) that eventually reduces sleep.\nExcess breaks down your muscle tissues and can cause chronic diseases. It can interrupt women’s menstrual cycle by disturbing the balance between progesterone and estrogen hormones.\nCardio exercises are best for reducing the chance of developing major health issues. But it will be only beneficial when done in proper guidance. Consult your physician before implementing cardio in your exercise regime. Stop cardio workouts if you feel soreness or lethargy. Listen to your body first and act wisely.", "label": "No"}
{"text": "In order to prevent the test base (e.g. the test anvil) from affecting the test result in any way, a minimum specimen thickness must be observed with the Brinell method (acc. to ISO 6506).\nThis minimum specimen thickness must be eight times the indentation depth for the Brinell method and can be taken from the table below.\nMinimum specimen thickness (in mm) for the Brinell method as a function of the average indentation diameter (in mm):", "label": "No"}
{"text": "A brown crystalline mineral consisting of a phosphate of cerium, lanthanum, other rare earth elements, and thorium.\nMore example sentences\n- The unusual age zonation is probably linked to the mineralogical association of monazite and apatite during metamorphic reactions.\n- I dutifully explained that the smoky spots were probably the result of natural irradiation caused by many tiny radioactive mineral grains, possibly monazite or xenotime.\n- They are found in minerals such as monazite and bastnasite, the main sources of which are in China and the USA.\nmid 19th century: from German Monazit, from Greek monazein 'live alone' (because of its rare occurrence).\nDefinition of monazite in:\n- The US English dictionary", "label": "No"}
{"text": "Water, Premier Protein® Shake Protein Blend (Milk Protein Concentrate, Calcium Caseinate, Whey Protein Concentrate), Cocoa Powder (processed with alkali), Contains 1% or less of the following: High Oleic Sunflower Oil, Inulin, Cellulose Gel and Cellulose Gum, Magnesium Phosphate, DATEM, Salt, Natural and Artificial …\n- 1 What is Premier protein made of?\n- 2 Are there any vegan protein shakes?\n- 3 Are premier protein drinks dairy free?\n- 4 Is Premier Protein a meal replacement?\n- 5 Which vegan protein is best?\n- 6 Is it bad to drink 2 Premier Protein shakes a day?\n- 7 Is Premier Protein bad for cholesterol?\n- 8 Does Premier Protein really have 30g of protein?\n- 9 Do vegans need protein powder?\n- 10 Is vegan protein better than whey?\n- 11 Does Premier protein make a plant-based shake?\n- 12 Are premier protein shakes gluten and dairy free?\n- 13 Which protein drinks are dairy free?\n- 14 What are the best protein shakes for losing weight?\nWhat is Premier protein made of?\nWater, Milk Protein Concentrate†, Calcium Caseinate†, Contains less than 1% of High Oleic Sunflower Oil, Natural and Artificial flavors, Inulin, Cellulose Gel and Cellulose Gum, Salt, Sucralose, Acesulfame Potassium, Carrageenan, Tripotassium Phosphate, Dipotassium Phosphate, Sodium Hexametaphosphate, Vitamin and …\nAre there any vegan protein shakes?\nOrgain Organic Nutrition Plant Based Protein Shake Just one ready-to-drink Orgain vegan shake contains 16 grams of organic plant-based protein from brown rice, hemp, chia, and flax—plus a fruit and veggie blend. Talk about an all-in-one shake! Fuel your day with smooth chocolate or vanilla bean flavor.22 mar. 2017\nAre premier protein drinks dairy free?\nThese are some popular ready to drink protein shakes that are NOT lactose free but may be low lactose: Premier Protein. Pure Protein.27 mai 2015\nIs Premier Protein a meal replacement?\nProtein shakes are not meant to replace a meal. Their role is to supplement your diet and make it easier to meet your daily protein requirements when you’re active. Ideally, these beverages should be consumed before and/or after exercise. Whey protein shakes are best for fuel lean muscle tissue growth.\nWhich vegan protein is best?\n1. Pea Protein. Share on Pinterest.\n2. Hemp Protein.\n3. Pumpkin Seed Protein.\n4. Brown Rice Protein.\n5. Soy Protein.\n6. Sunflower Seed Protein.\n7. Sacha Inchi Protein.\n8. Chia Protein.\nIs it bad to drink 2 Premier Protein shakes a day?\nThe short answer is yes, you can have more than one protein shake per day.1 mar. 2021\nIs Premier Protein bad for cholesterol?\nSome protein may even be good for your heart. Researchers have found that eating soy protein (which is found in our Premier Protein® bars) daily, as part of a diet low in fat and cholesterol, can help maintain a healthy heart.11 oct. 2019\nDoes Premier Protein really have 30g of protein?\nEach Premier Protein shake contains 30 grams of protein, complete with all of the essential amino acids, 1g of sugar, 5g carbs,160 calories, 24 vitamins & minerals, and is also low in fat.\nDo vegans need protein powder?\nDo you need to drink vegan protein powder shakes now that you’re not eating meat. No, you do not! Yes, protein is important — but you’re most likely getting “enough” protein on a plant-based diet, without supplementing. And protein powders (even the “plant-based” ones) are best avoided altogether.\nIs vegan protein better than whey?\nVegan Protein is great, but it’s not necessarily better than Whey. Actually when comparing the essential protein nutrients (as it’s a protein supplement after all), gram-for-gram whey still comes out on top, quite convincingly (around 20-30% more BCAAs in Whey).9 mar. 2018\nDoes Premier protein make a plant-based shake?\nSoy is absorbed slower than whey but faster than casein, and is unique in that it is a “complete” plant-based proteins. … Our shakes offer a proprietary blend of milk proteins, while our bars deliver a blend of soy and whey.11 oct. 2019\nAre premier protein shakes gluten and dairy free?\nGluten free. Low fat. 24 vitamins & minerals. Maintaining a healthy lifestyle can be hard.\nWhich protein drinks are dairy free?\n1. Oath Organic Oat Milk + Plant Protein.\n2. Soylent Complete Protein.\n3. Ripple Vegan Protein Shakes.\n4. Happy Viking Triple Chocolate Protein Shake.\n5. Vega Protein & Greens.\n6. TB12 Vanilla Plant-Based Protein.\n7. PlantFusion Complete Protein.\n8. Elevate Plant-Based Performance Protein.\nWhat are the best protein shakes for losing weight?\n1. Optimum Nutrition Gold Standard Whey Muscle Building and Recovery Protein Powder.\n2. Supreme Nutrition Diet Whey.\n3. PhD Nutrition Diet Whey Protein Powder.\n4. RSP Nutrition AvoCollagen Protein Powder.\n5. SlimFast High Protein Shake Powder.", "label": "No"}
{"text": "Turrialba is the name of the fifth region of the province of Cartago, even though it represents 52% of the latter.\nTurrialba is set between the conservation zone of the Volcánica Central cordillera and the park La Amistad.\nIts population reaches about 70 000 inhabitants and the town of Turrialba, capital of the region, has about 35 000 inhabitants.\nThe climatic features and the type of ground in Turrialba, where there are valleys as well as fertile broken areas, allowed the development of cultures such as coffee, sugar cane, pejibaye, macadamia, fruit trees and farming.\n“Torre Alba” is the name given by the Spanish to the Volcán Turrialba (3339m) because of the extremely high columns of water vapor erupting from the crater. It is a protected area, declared a national park in 1955.\nFrom a geomorphologic point of view, the volcanoes Turrialba and Irazú form one single system. Indeed, from the mountain’s peak, you can easily reach the Irazú’s side. In one of the cols between the sides, there is a cavity where you can hear sounds of the volcanic activity.\nThe inhabitants say that “it’s a proof of the fact that the two volcanoes join together from underneath”.\nThe volcano Turrialba is one of the few volcanoes in the world of which you can reach the crater to see the sulfur smokes very closely during a major part of the year.\nTropical Agronomic Canter of Investigation and Education since 1942, the CATIE is at the same time a university and a scientific center for agriculture, management and conservation of natural resources. It has the biggest public library in Central America.\nThe CATIE has a botanic garden of 45 ha which allows the discovery of more than 95 species of native trees and more than 160 trees from different parts of the world.\nNational monument of Guayabo\nThis monument is one of the Costa Rican archeological sites which represent the highest standard of social and cultural way of life of the prehispanic societies in the country. The site (233 ha) was declared archeological patrimony in 1973.\nThe site possesses circular structures made of stone that used to be houses and surrounding walls as well as streets, draining systems, aqueducts or water holder. There are a lot of carved stones too (petrography).\nReventazón and Pacuare Rivers\nThe Reventazón is one of the most important rivers in Costa Rica, because of its length (152 km) and its hydroelectric potential. According to the legend, it is on its banks that the white man settled down for the first time; the indigenous population lived, grew and the suffered on the Reventazón sides.\nThere are other very beautiful rivers in the region of Turrialba such as the Pejibaye River. It is worth discovering this significant Reventazón ’s tributary where you can swim or visit the big cracks between the mountains that are used as drainpipes in the Atlantic region. The canyon possesses forests of giant trees, small rivers, coffee and sugar cane exploitations and small villages.", "label": "No"}
{"text": "Age-Defying Hydrosol Serum for All Skin Types\nEmerald Sun Hydrosol Serum is a light, skin-quenching, 'heavy-water', serum that helps to soothe, hydrate and energize skin for a dewy-fresh and brighter look. Skin-awakening peony root and plankton extracts with protective and skin-boosting alpine buddleja and edelweiss plant extracts, help to minimize the appearance of skin dryness and aging effects. Beta glucan, derived from the cell walls of oats, enhances a renewed look of calm, healthy skin.\nApply 1-3 pumps to cleansed face and neck including eye area. Use morning and night for best results. Follow with an application of the ISUN facial moisturizer for your skin type, or for maximum age-defying results, follow with ISUN Phyto-Infusion Facial Serum and the ISUN facial oil for your skin type. Shake before use.\nAloe vera, Beta-glucan, Peony root, Buddleja extract, Edelweiss extract, Plankton extract, Green tea extract, Beta glucan, Hyaluronic acid, Neroli oil.\nStorage: Preserve product integrity by keeping out of sunlight and storing in a cool, dry place. May be refrigerated for maximum product protection.\nSuitable for Vegans. Gluten-free. Non-Toxic. Preserved with Aspen bark extract.\nAloe barbadensis (aloe vera) leaf juice*; Aqua† (spring water); beta-glucan (oat-derived); Saccharide isomerate (plant sugar complex)**Buddleja davidii extract*; Leontopodium alpinum (edelweiss) extract*; Paeonia tactiflora (peony) root extract, trehalose (plant sugar)*; Silica-mineral complex; Populus tremuloides (aspen) bark extract; Glycerin*; Plankton extract; Sodium hyaluronate (hyaluronic acid concentrate); Camellia sinensis(green tea) leaf extract*; Citrus aurantium (neroli) flower oil\n* Certified Organic † Wildcrafted **EcoCert Approved", "label": "No"}
{"text": "The Grown-up Congenital Heart Disease Working Group represents a platform for collaboration between congenital heart disease specialists with a common interest, particularly regarding clinical cardiology, imaging, ventricular function, valvular heart disease and pulmonary hypertension.\nMoreover, the WG provides guidelines, position papers and training recommendations.\nOur annual meeting, held in spring, is an outstanding forum to share research results and to meet colleagues in the field.\nCardiologists with a dedicated interest and special knowledge are needed to improve future patient care and we invite you to join us.\nAims of the ESC WG GUCH are:\n- To promote, to maintain and to pursue excellence in the care of adults with congenital heart disease;\n- To improve the quality of care by endorsing, supporting and organising educational programmes in adult congenital heart disease;\n- To establish guidelines for the treatment and management of adults with congenital heart disease;\n- To establish close links with other groups/societies dealing with adult congenital heart disease patients.\nUse the following contact form to contact the WG:\nAlso please make sure to follow our facebook and twitter channels for updates:", "label": "No"}
{"text": "Regardless of the type of surgery, caring for your cat after surgery can be a challenge. Cats may be uncomfortable, experience pain, and their ability to move around freely may need to be temporarily restricted. Knowing what to expect, and what to watch out for, can make caring for your cat after surgery less stressful for you and help your cat recover faster.\nAfter surgery cats need a quiet place to rest and preferably should be kept away from other pets or small children.\nAt Cabana Chats cats are able to still enjoy fresh air, some sun and the sound of the birds ( and the sea ) while they recuperate. As well as being able to see the other guests while they lie in a bed of soft blankets with easy access to a litter box, food and water.\nWe are also able to monitor signs that may indicate that your cat is in pain like behavior changes (quieter than normal, hiding, pacing, aggression), decreased or no appetite, increased respiratory rate, or vocalization. the use of the litter box and any reasons for concern and same applies to the intake of food and water\nAdministering medication and trips to the vet for dressing changes etc and normally additional charges.", "label": "No"}
{"text": "Photographer for my pleasure. I come from a small village in the middle of the Beskydy Mountains in the Czech Republic.\nNeed more usage rights?\nRequest a custom license\nreflection water tree autumn nature lake morning sky plant adult beauty in nature tranquility sunlight forest scenics - nature leisure activity full length tranquil scene trip vacation body of water holiday one person rear view lifestyles women men day landscape walking outdoors travel land waterway wilderness environment cloud activity travel destinations winter pinaceae coniferous tree relaxation idyllic non-urban scene female standing copy space — in Paltamo, Finland", "label": "No"}
{"text": "Utilize este identificador para referenciar este registo:\n|Título:||Biodegradation of ofloxacin, norfloxacin, and ciprofloxacin as single and mixed substrates by Labrys portucalensis F11|\n|Autor:||Amorim, Catarina L.|\nMoreira, Irina S.\nMaia, Alexandra S.\nTiritan, Maria E.\nCastro, Paula M.L.\nLabrys portucalensis F11\n|Citação:||AMORIM, Catarina L... [et al.] - Biodegradation of ofloxacin, norfloxacin, and ciprofloxacin as single and mixed substrates by Labrys portucalensis F11. Applied Microbiology and Biotechnology. ISSN 1432-0614. Vol. 98, n.º 7 (2014), p. 3181-3190|\n|Resumo:||Fluoroquinolone (FQ) antibiotics are extensively used both in human and veterinary medicine, and their accumulation in the environment is causing an increasing concern. In this study, the biodegradation of the three most worldwide used FQs, namely ofloxacin, norfloxacin, and ciprofloxacin, by the fluoroorganic-degrading strain Labrys portucalensis F11 was assessed. Degradation occurred when the FQs were supplied individually or as mixture in the culture medium, in the presence of an easily degradable carbon source. Consumption of individual FQs was achieved at different extents depending on its initial concentration, ranging from 0.8 to 30 μM. For the lowest concentration, total uptake of each FQ was observed but stoichiometric fluoride release was not achieved. Intermediate compounds were detected and identified by LC-MS/MS with a quadrupole time of flight detector analyzer. Biotransformation of FQs by L. portucalensis mainly occurred through a cleavage of the piperazine ring and displacement of the fluorine substituent allowing the formation of intermediates with less antibacterial potency. FQ-degrading microorganisms could be useful for application in bioaugmentation processes towards more efficient removal of contaminants in wastewater treatment plants.|\n|Aparece nas colecções:||CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review|\nFicheiros deste registo:\n|Amorim et al., 2014_FQs.pdf||601 kB||Adobe PDF||Ver/Abrir Acesso Restrito. Solicitar cópia ao autor!|\nTodos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.", "label": "No"}
{"text": "Canyoning is by far our most popular activity. It is a readily available activity within the local area which can be run in a broader range of conditions. It is an exciting, adventurous activity that can be modified to fit both heavy and light rainfall, allowing the activity to be different for every group. However, there also a variety of activities that are at the mercy of the sea. Activities such as surfing, kayaking and coasteering all require specific conditions from the sea in order for the most to be made out of the activity.\nSurfing is the most obvious activity to be affected by the sea. Surfing is greatly affected by wind conditions and swell. Surface pressure and wind maps can be used to determine the likelihood of good waves on a particular day, so prior analysis is required by companies to determine whether to run a surfing activity on a day. However, surfing in good conditions is a transcendent feeling that no other activity could mimic.\nKayaking is an activity which can be done in both a sea and river environment. The conditions that affect surfing have a similar influence on sea kayaking. However, there is always the possibility to go white water rafting, provided a good river flow.\nCoasteering is an activity which is similar to canyoning, however, it is based around jumping off cliffs into the sea rather than off waterfalls. The jumps are bigger and the caving systems are spectacular, however very specific conditions are required, so in many cases an earlier or later time is necessary in order for the activity to be safe.\nAll activities are based in the South Wales area, in the Cardiff and Swansea areas.", "label": "No"}
{"text": "[Na/Fe] abundance ratios as a function of [Fe/H] for the 14 samples selected from the literature. The code-labels are listed in Table 1. The [Na/Fe] and [Fe/H] values are those of the original papers. The leftmost and rightmost dotted lines indicate the metallicity range of the bulk of GCs in the FLAMES survey (see e.g. Carretta et al. 2009a,b). The line at [Fe/H] = −1.56 dex shows the metallicity of NGC 6752, our test case.\nCurrent usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.\nData correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.\nInitial download of the metrics may take a while.", "label": "No"}
{"text": "Bio World supplies a complete range of organically grown fruit and vegetables. We are 100% organic. Why? Because we believe in the commercial potential of organic produce, with consumers all over the world looking for naturally grown fruit and vegetables.\n> read more about Bio World\nAt Bio World we offer a huge range of organically grown fruit and vegetables. Our range not only includes the bestsellers but also new, less well-known products. We boost the market opportunities for organic products.\n> Read more about Bio World’s products\nGrowing fruit and vegetables organically harks back to a time when fruit and vegetables were always grown in a natural way. This natural approach to growing is still practised today, but it is now done in a more efficient, professional manner. This results in fruit and vegetables with a full, intense flavour.\n> read more about growing at Bio World\nPlease contact your sales representative for more information.", "label": "No"}
{"text": "Human figures that were broken to get rid of evil were found in Ulucak Mound in western Turkey. A total of 5 of these figurines were found. Archaeologists think that these figurines date back to around 8000 years ago.\n5 human figures with very important meanings dating back 8000 years were found in Ulucak Mound in Izmir, Turkey. Prof. Dr. Özlem Çevik who heading the excavations at Ulucak Mound, ”There was some purpose in breaking the figures. These; they could be broken and thrown to represent birth, death, the building of houses, harvest time and abundance, as well as to destroy bad possibilities.”\nWhere is the Ulucak Mound?\nUlucak Mound is located in the western part of Turkey, in the province of Izmir. The mound was first discovered by British researcher David French in 1960.\nAt that time, it was determined that it was contemporary with the Neolithic period with the first finds. Excavations have been continuing since 1960 with various archaeologists. The Ulucak Mound is the first settlement of İzmir. Late/middle Chalcolithic, Early Bronze Age and Roman/Byzantine ruins were found in this area.\nThe current excavation director, Prof. Dr. Özlem Çevik gave brief information about the studies, ” Ulucak Mound is one of the earliest Neolithic centers of western Anatolia. It was inhabited uninterruptedly, starting from 8 thousand years ago until 1100. ”\n”We found 5 human figures during this year’s excavation season. These are made entirely of clay. We’ve found some of them whole, and that’s very rare. Mostly we found the head broken or only the head part. Sometimes we find only its arm and leg broken, just like this year.”\nThe head of the excavation, Prof. Dr. Çevik noted that they found the figures inside the houses, in the courtyard and on the street of the mound. In addition, previously these figures were thought to have a sacred meaning for the mother goddesses, but with new studies, ıt is thought that they were broken and thrown away to bring more abundance and fertility and to get rid of evil.\nNumerous seals, spindle whorls and bench weights were found in Ulucak Mound again this season. These finds also show that the Aegean region was probably the center of textile production.\nWhat has been found so far in Ulucak Mound shows that it will give us more information in the future.\nCover photo: Hurriyet", "label": "No"}
{"text": "R. Renaudin L’Espiègle Champagne 1er Cru Brut Blanc de Blancs 1996\n1.5L Magnum Bottle\nAlcohol by volume\nYears in Blend\nAnnual cases produced\nAging duration months\nVine Training Notes\nClassical pruning methods practiced in champagne. For the chardonnay the pruning method used is Chablis.\nThe specificity and the quality of our champagne begin from a qualitative approach in the vineyards. It is the terroir that expresses the specificity and the particularity by combining different elements like climate, exposition, geographical localization and human factors. The vineyard is managed by combining the qualitative work of the soil and permanent grassing. We apply the plant protection products for the protection of the vines at low dose, only if it is necessary with a reasoned approach and sustainable approach.", "label": "No"}
{"text": "You are actually most likely maintaining your physical body hydrated if you are actually consuming alcohol sufficient water. Maintaining your body system moistened also enables your body to correctly absorb the nutrients from the food items you consume. The greatest supplement to take is actually one that aids your body keep water.\nDiet regimen Internet Page pills have made terrific strides in the last couple of years. Yet if you wish to drop weight, you need to also keep your consuming behaviors in examination. Diet regimen supplements are actually just among the various resources you need to have to slim down.\nThis consists of consuming the correct meals and preventing eating foods that are actually high in fat as well as calories. If you eat a lot of carbs, you are specifying your own self up for breakdown. To prevent the excess fat from developing, you need to have to keep away coming from higher carb meals.\nThere relevant web site are actually a lot of misconceptions regarding diet pills, and a ton of individuals think that they are some sort of miracle drug that will amazingly eliminate their fat deposits and disappear their unnecessary pounds. While there is actually no treatment for excessive weight, weight loss supplements may be a reliable tool to aid you get rid of the added weight. That being actually claimed, you need to become realistic with the efficiency of these products.\nPeople have been counting on diet regimen supplements to lose weight for many years. There is actually no replacement for challenging job and also devotion when it arrives to body weight reduction. Even if the supplements don’t operate for you, keep up your attempts and also keep your diet in check.\nFat loss supplements are raising in level of popularity and also some people need to know what is good and what is actually certainly not. The accessibility of more medications for weight loss has actually sustained the necessity for these supplements.\nThere are actually visit this link prescribed medicines and supplements that might function far better than diet plan tablets, including Obagi, which is actually a fat loss supplement. Many diet plan supplements are actually weight reduction supplements. It is actually tough to find a pill that will certainly certainly not have side effects.\nThere are actually no warranties that any kind of supplement can aid you drop weight or even keep it off. Some supplement will possess no benefit and also some will work yet not for long.\nThere are actually a few points to look at when looking for weight-loss. The first is actually to look at if the supplement you are actually checking out is actually safe. A lot of supplements include dangerous chemicals that have actually been actually shown to cause troubles.\nPeople are actually coming to be much more wellness mindful and also some health teams are actually starting to take weight loss supplements and prescribed drugs more very seriously. If a supplement will definitely do what it is expected to do, they don’t recognize exactly how to determine. A supplement needs to have to become assessed in scientific labs to ensure that it will certainly create the outcomes that people wish.\nThere are actually some items that do actually help make effective weight loss simpler. When you take your nutrients along with food items they are taken in faster and also you believe fuller. This has actually been actually presented to help with fatty tissue absorption of nutrients.\nAnother wonderful technique to create reducing weight much easier is actually to change to protein. If you are actually eating healthy protein everyday after that the body may continue to repair your muscle tissue. Your muscular tissues may carry even more body weight as well as the fat can be burnt.\nYour body system’s potential to get rid of body fat and outlet it away as glycogen has a direct relationship to the amount of protein you consume. The body system will certainly still get rid of a whole lot of fat deposits however it will also keep some of it away as glycogen if you make an effort to consume too a lot healthy protein without adequate carbs. The physical body is going to certainly not burn as lots of calories as it should when this occurs.\nDiet tablets and effective weight loss supplements need to be taken along with a well-balanced diet regimen and also some workout. The supplements need to become integrated with a well-balanced diet to make sure that your physical body performs not drop the capability to shed fat.\nLots of people are putting a considerable amount of initiative into burning fat and after that when it comes opportunity to put their weight back on, they are certainly not shedding sufficient calories to accomplish it. This is due to the truth that they weren’t consuming sufficient to shed the additional body weight. They are actually also enjoying excessive fats daily.\nEverybody requires to consume much less fats than they do. Even though an individual absorbs the right amount of fats, this doesn’t imply that they are eating the correct kinds of foods. It is necessary to consume foods that are going to assist the body system get rid of fatty tissue as opposed to establishment it away as glycogen.\nAs long as the person recognizes the capacity for negative effects and that they are not receiving all the nutrients they need to have at that point taking diet tablets as well as supplements are going to be actually less complicated. Make sure to utilize good sense just before taking a supplement.\nDiet supplements are just one of the many devices you require to lose weight.\nWhile there is no cure for obesity, body weight loss supplements can be actually an effective tool to help you get rid of the additional weight. A lot of diet regimen supplements are actually weight reduction supplements. Folks are actually coming to be much more health aware as well as some wellness teams are actually starting to take body weight loss supplements and also prescription medicines extra very seriously. A lot of people are putting a whole lot of effort right into losing body weight as well as after that when it comes time to place their weight back on, they are certainly not getting rid of sufficient fats to do it.", "label": "No"}
{"text": "THE SCOPE OF THE PROBLEM:\nSome of the factors affecting women are:\nDyslipidemia, diabetes, over the age of 55 years, family history of premature coronary artery disease, hypertension, smoking, peripheral artery disease, obesity, menopause, metabolic syndrome, sedentary lifestyle, autoimmune disease, chronic kidney disease and pregnancy related disorders.\nWomen may present with chest pain, pressure or discomfort, unusual upper body discomfort, shortness of breath at rest or on exertion, cold sweats or diaphoresis, fatigue, lightheadedness or sudden dizziness, palpitations or nausea and vomiting.\nAs women, let’s invest in our health. Should we experience any of these symptoms, seek medical attention and advice from your physician. He/she will be able to make an assessment and establish your treatment, which may include test such as an echocardiogram, coronary calcium score, exercise stress test and blood test.\nIf you are on medication, your physician may make adjustments to ensure optimum stabilization of your symptoms.\nBe diligent and consistent with taking your medication. Monitor your blood pressure, glucose and cholesterol levels. Avoid alcohol or smoking. Eat foods rich in fiber such as grains, lentils, vegetables and grains. Eat fish which has omega 3 fatty acids. Use less salt and sugars and decrease your carbohydrate intake. Become physically active and exercise such as brisk walking for 30-50 minutes at least 5 times/week. If you have not been physically active, please discuss with your doctor and always start of gradually, intensifying as you progress and allow for proper warm up and cool down phases. Find time for rest and relaxation and avoid stress as much as possible. These will help to improve your overall health and your heart will love you for it.", "label": "No"}
{"text": "Discussion Lowry assay The Lowry method is one of the most sensitive and widely used.\nScience Advisor fluidistic said: What's going on with the wavefunction of the electron when we try to detect it but we fail? In that case the wavefunction does not collapse into an eigenstate I suppose, but we still modified it simply because the atom acts as a perturbator potential?\nIs it just as simple as that? Please note that something like a single distinguished shape of the interference pattern does not exist. You shift the positions of the peaks around if you change the relative phase.\nFor convenience, most of the time the pattern is shown for 0 phase difference, but this is not required at all. Accordingly, everything that changes this relative wave function, will change the interference pattern. This may be achieved by shooting a light field at some angle to the slits or for example by placing a thick sheet of glass at one of the slits as it shifts the phase of the light field at this point.\nPlacing an atom at the slit will introduce a similar phase shift for electrons and is basically the equivalent of the sheet of glass I described beforehand for a double slit using light.Methods to Identify and Detect Microbial Contaminants in Drinking Water Mark D. Sobsey The transmission of infectious diseases via contaminated water continues to be a risk to public health in the United States and throughout the rest of the.\nThe presence of the mask prevents automatic detection of change. Change must now be detected by a slower, higher-level process. Basically, you have to search the scene, object by object until you happen to find the changed object. Note: If the solution turns to blue-black colour it indicates the presence of starch in the solution.\nObservation. The test solution turns blue-black in colour.\nInference. Iodine reacts with starch to form starch/iodine complex which has a blue-black colour.\nThe appearance of blue-black colour confirms the presence of starch in the given food sample. 3. This experiment tests only for the presence of fat; it does not differentiate between types of fats. From the foods you chose, determine saturated versus unsaturated fats and whether the product has been hydrogenated or not.\nGive reasons for your conclusions. To test the presence of starch in the given food sample.\nApparatus and materials required: Test tubes, test-tube stand, test-tube holder, spirit lamp, dropper, filter paper, iodine solution, distilled water, and foodstuff (potato, rice, wheat or maize grains).\nLHC Experiment May Detect Presence of Parallel Universes. Written By: Chris Draper October 30, SHARE (0) TWEET (0) PIN (0) and that the benefits of the experiment far outweigh its risks.(1) if the LHC does detect the presence of mini black holes at high energy levels, it will provide evidence for the existence of extra dimensions.", "label": "No"}
{"text": "Pacifica is the bees knees\nPacifica always has the best products! My eyes felt renewed and refreshed after using these eye patches. I saw an improvement in the skin under my eyes - more evened color and less puffy.\nLightening but not Magic\nI used these incorrectly (didn't take off the mesh/sticker), and it still kind of worked! It was lightening, but I still have dark circles and bags. However, as someone with warm yellow undertones, a lot of lightening under eye products I've used lighten the skin rather than circles, so it looks bruised, and this didn't do that, so I was impressed. I thought that it had a faint coconut scent like other Pacifica products I've had, and they're reasonably priced. Would try (properly!) in the future!", "label": "No"}
{"text": "So, what is the best way for YOU to get rid of dandruff?\nThe best course of action is to experiment until you find something that works for you. And, even if you do discover it, you should switch it up every now and then. If you stick with a treatment for an extended period of time, it may become less effective. Bummer.\nSo, what options do you have? Here is a list of items that are effective in the fight against dandruff. When you’re out shopping for shampoo, keep an eye out for these items:\nClimbazole is an antifungal medication that is used to treat malassezia, a fungus that causes dandruff in the scalp.\nCoal tar has a slowing effect on cell turnover. It is also effective for skin conditions such as seborrheic dermatitis (flaking of the skin) and psoriasis.\nKetoconazole is an antifungal medication that works by attacking the fungus that causes dandruff. You can also take it to treat seborrheic dermatitis if you have it.\nMiconazole is an additional anti-fungal medication that is used to treat dandruff.\nSeveral natural oils, such as castor oil, coconut oil, and tea-tree oil, are effective in the treatment of dandruff.\nOctopirox is an anti-dandruff medication that relieves the symptoms of dandruff, particularly the itching and flaking.\nPiroctone Olamine is an anti-bacterial drug that works to eliminate the bacteria that causes dandruff.\nBHA (beta hydroxy acid) Having antibacterial capabilities, salicylic acid is a BHA. It loosens dead skin cells, allowing you to wash away the flaky pieces with relative ease. However, it can cause your scalp to become dry.\nSelenium sulfide has the effect of slowing down cell turnover. However, it can discolor blonde, grey, or chemically colored hair, and it is particularly effective against seborrheic dermatitis and psoriasis.\nIts antimicrobial characteristics assist in the regulation of dandruff, seborrheic dermatitis, and psoriasis. Sulfur is also beneficial in the treatment of acne. However, it has the potential to irritate your scalp.\nZinc pyrithione is a zinc derivative that has antifungal qualities, which means it can prevent the growth of bacteria that cause illnesses from spreading. It is also effective in the treatment of seborrheic dermatitis.\nI have always been fond of make-up ever since my adolescent days. I would try out different products on myself. With time I realized that while doing make-up can be fun, I also need to take care of my skin. I follow a strict skincare regime now and hope more people understand the importance of doing the same if they have access to the right products.", "label": "No"}
{"text": "Endoscopic Examination Package\nWHY IS IT WORTH EXECUTED ENDOSCOPES OF THE ALIMENTARY TRACT?\nCommon gastrointestinal diseases include stomach ulcers, colorectal cancer and stomach cancer. Gastric problems usually appear through bloating, abdominal pain, indigestion, heartburn, constipation or bloody stools. Unfortunately, these symptoms can be a serious disease of the large intestine. With such symptoms, it is worth performing gastrointestinal endoscopy, including gastroscopy and colonoscopy.\nGastroscopy is a method of examination of the initial gastrointestinal tract, which helps the doctor to check the condition of the esophagus, stomach and duodenum.\nColonoscopy allows you to see the entire colon thoroughly, takes diagnostic material or perform polypectomy (remove polyps, most of which arise tumors).\nWHAT CONTAINS THE ENDOSCOPE BACKGROUND PACKAGE:\n- General anesthesia,\n- Gastroenterological consultation,\n- Abdominal ultrasound,\n- Resting ECG,\n- HP test.\nPackage price: PLN 1590.\nThe package is available for use within 30 days of the first visit / examination.\n© Medpolonia. Project and realisation: Iguana Studio", "label": "No"}
{"text": "By Denise S. Dawson on June 03 2018 21:51:46\nDogs can either serve as watchdogs or guard dogs or both. A watchdog s job is to bark and raise the alarm when a stranger enters your property. Their job is to warn you. Many small dog breeds make great watch dogs. Whereas a guard dog s job is to look intimidating and protect his family by keeping intruders out. Some breeds are great guard dogs but not great watchdogs. And vice versa. And a few breeds are both great guard dogs and great watchdogs.\nToday there are over 400 recognized breeds of dogs in the world. Many of them have historical origins dating back hundreds, even thousands of years. Wherever humans have lived, dogs have been alongside them performing various tasks. One of the reasons dogs have been such a successful species is because they are so adaptable. They have made themselves useful in countless ways to humans so we kept feeding them, providing shelter for them, and, yes, breeding them. It’s no accident that we have dogs able to hunt, herd, guard, track, and do so many other things at an expert level. Humans figured out early on that if you bred dogs that were good at these things, you would get offspring that were also good at doing them. All of these jobs performed by dogs were necessary for our own species to survive. It’s no secret that we owe a lot to dogs, just as we do to other animals.\nEvery breed can be trained to learn almost every command. However, some breeds learn a lot faster than others - making them a lot easier to train. These highly intelligent breeds pick up a command after only about five or six repetitions, they more often respond on the first time you give the command, and they remember commands even if they are not practiced often. They also learn commands even when the trainer is inexperienced and makes mistakes. So if you do not have a lot of the time to spend dog training, or you are the impatient type who gets frustrated easily, choose a breed which has a high ease of training rating.\nThese are some of the factors to consider when making a decision about which breed is right for you. With these points in mind, browse through the dog breed profiles and discover which dog will be a suitable match for you.\ndog breed lists\nbest dog breeds\ntop dog breeds", "label": "No"}
{"text": "Another text which teaches yoga with an Advaita point of view is the Yoga-Yājñavalkya. This work contains extensive teachings on ten Yamas (ethical rules) and ten Niyamas (duties), and eight asanas. It also discusses a theory of nadis and prana (vital breath), and follows this with instructions on pranayama (breath control), pratyahara (sense withdrawal), meditation on mantras, meditative visualizations and Kundalini.\nThe motor proteins actin and myosin generate the forces exerted by contracting muscles. Current recommendations suggest that bodybuilders should consume 25–30% of protein per total calorie intake to further their goal of maintaining and improving their body composition. This is a widely debated topic, with many arguing that 1 gram of protein per pound of body weight per day is ideal, some suggesting that less is sufficient, while others recommending 1.5, 2, or more. It is believed that protein needs to be consumed frequently throughout the day, especially during/after a workout, and before sleep. There is also some debate concerning the best type of protein to take. Chicken, turkey, beef, pork, fish, eggs and dairy foods are high in protein, as are some nuts, seeds, beans, and lentils. Casein or whey are often used to supplement the diet with additional protein. Whey protein is the type of protein contained in many popular brands of protein supplements and is preferred by many bodybuilders because of its high Biological Value (BV) and quick absorption rates. Whey protein also has a bigger effect than casein on insulin levels, triggering about double the amount of insulin release. That effect is somewhat overcome by combining casein and whey. Bodybuilders are usually thought to require protein with a higher BV than that of soy, which is additionally avoided due to its claimed estrogenic properties. Still, some nutrition experts believe that soy, flax seeds and many other plants that contain the weak estrogen-like compounds or phytoestrogens, can be used beneficially, as phytoestrogens compete with estrogens for receptor sites in the male body and can block its actions. This can also include some inhibition of pituitary functions while stimulating the P450 system (the system that eliminates hormones, drugs and metabolic waste product from the body) in the liver to more actively process and excrete excess estrogen. Cortisol decreases amino acid uptake by muscle, and inhibits protein synthesis.\nThis terse definition hinges on the meaning of three Sanskrit terms. I. K. Taimni translates it as \"Yoga is the inhibition (nirodhaḥ) of the modifications (vṛtti) of the mind (citta)\".Swami Vivekananda translates the sutra as \"Yoga is restraining the mind-stuff (Citta) from taking various forms (Vrittis).\" Edwin Bryant explains that, to Patanjali, \"Yoga essentially consists of meditative practices culminating in attaining a state of consciousness free from all modes of active or discursive thought, and of eventually attaining a state where consciousness is unaware of any object external to itself, that is, is only aware of its own nature as consciousness unmixed with any other object.\"\nModern yoga was created in what has been called the Modern Yoga Renaissance by the blending of Western styles of gymnastics with postures from Haṭha yoga in India in the 20th century, pioneered by Shri Yogendra and Swami Kuvalayananda. Before 1900 there were few standing poses in Haṭha yoga. The flowing sequences of salute to the sun, Surya Namaskar, were pioneered by the Rajah of Aundh, Bhawanrao Shrinivasrao Pant Pratinidhi, in the 1920s. Many standing poses used in gymnastics were incorporated into yoga by Krishnamacharya in Mysore from the 1930s to the 1950s. Several of his students went on to found influential schools of yoga: Pattabhi Jois created Ashtanga Vinyasa Yoga, which in turn led to Power Yoga; B. K. S. Iyengar created Iyengar Yoga, and systematised the canon of asanas in his 1966 book Light on Yoga; Indra Devi taught yoga to many film stars in Hollywood; and Krishnamacharya's son T. K. V. Desikachar founded the Krishnamacharya Yoga Mandalam in Chennai. Other major schools founded in the 20th century include Bikram Choudhury's Bikram Yoga and Swami Sivananda of Rishikesh's Sivananda Vedanta Schools of Yoga. Modern yoga spread across America and Europe, and then the rest of the world.\nSLPY offers dynamic, HEATED yoga classes that focus on balanced movement, strength, and breath. SLPY classes meet you where you are and are accessible to everyone—regardless of your age, flexibility, and experience. Built on the foundation of Baptiste yoga, our powerful flow can help you reduce stress, lose weight, heal injuries, increase focus, and much more.", "label": "No"}
{"text": "Prenatal massage has many benefits beyond relaxation and bodywork. It can help reduce swelling, ease muscle pain and improve blood circulation and help release hormones that feel good. Here are some of the most significant benefits. Continue reading to learn about the many advantages of massages during pregnancy for women who are expecting. We also look at the numerous benefits of aromatherapy as well as essential oils. Here are some suggestions to get you started:\nMassage can help reduce fluid retention during pregnancy. Massages increase circulation and reduce stress, which helps reduce edema. Certain foods also contribute to fluid retention. Salt is a common cause however you can substitute it with spices or herbs. Also, be sure to limit your consumption of processed foods, which contain high levels of trans fat and sodium. Many foods can be natural diuretics that help balance fluids.\nMassage therapies that are specifically designed for pregnant women are safe for you and your baby. Massage can help reduce stress hormones that are present in the body and improve circulation while keeping the lymphatic system functioning at its peak. It also helps reconnect your mind and body. Massage can be a source of relief and comfort during stressful times, like when you are worried about the growth of your child. Get your massage now to enjoy the benefits. 청주출장마사지 Also, make sure to talk to your prenatal healthcare provider about the benefits and risks of prenatal massage therapy.\nReduces muscle pain\nPrenatal massage benefits expectant mothers with a variety. It encourages relaxation and rest as well as enhancing relaxation. Massage during pregnancy is safe for both mother and baby as trained practitioners use specific techniques specifically designed for pregnant women. This massage therapy improves circulation, eases muscle pain and tension, and improves sleep. It improves oxygenation and circulation in the soft tissues. Furthermore, it is beneficial to the health of the newborn baby, as it helps prevent fetal distress.\nThe muscles that support the mother’s uprightness during pregnancy are working extra hard. Toxins and other bodily wastes build up in the muscles, causing them to become swollen and cause nerve endings to become irritated. Prenatal massage can ease this discomfort by breaking down adhesions, releasing trigger points, and improving the flow of blood and oxygen levels. It also helps in the elimination of harmful toxins. Pregnancy massage is a wonderful method to take some time to relax and feel healthier.\nImproves blood flow\nMassage can be a wonderful method of increasing circulation during pregnancy. The increased circulation delivers more oxygen to the cells and assists in removing metabolic waste. This helps support the growth of the baby. It also alters hormones that are associated with stress. Regular massage has been shown to decrease stress hormones, increase serotonin and norepinephrine levels and lower cortisol. These hormones are good for the development of the fetus.\nThe benefits of massage for prenatals extend well beyond the foetus. Massage during pregnancy can help mom feel calm and relaxed throughout her pregnancy. It decreases the risk of developing edema. This is an issue where blood accumulates in the legs or arms. Massage stimulates soft tissues and helps reduce the buildup of fluid around joints. It improves blood circulation and improves the lymphatic system’s efficient. It helps eliminate toxins and waste from your body. It can also help alleviate stress-related symptoms such as morning sickness, constipation and depression, as well as insomnia.\nFeel-good hormones are released\nMother and baby both experience many changes during pregnancy. The body is constantly developing new tissues, cells and blood in order to support a growing baby. It can also cause stress, which can affect a woman’s emotional and physical health. Massage during pregnancy is a great way to relieve anxiety and provide a rejuvenating and relaxing experience. It can also boost levels of the hormones that feel good, which can help women relax and enjoy better sleep.\nThe benefits of prenatal massage can be felt by mom and baby. Both mom and baby can benefit from prenatal massage. Massage can increase the levels of good mood hormones and reduces stress and depression hormones, helping a pregnant woman rest and sleep better. Massage can also help women overcome fatigue every day which is a common symptom of pregnancy. Massage can make women feel more positive and energetic, making her feel happier.\nHelps prevent preterm labor\nIf you’re concerned about the risk of preterm labor, you might consider giving yourself a massage. While massage isn’t a panacea but it can help keep a healthy pregnancy environment for your baby. Here are some advantages of massage before birth. Although there are numerous advantages to massage, it is important to know that there are some risks.\nIf you’re getting a prenatal massage, you’ll most likely lie on your side or sit upright , but slightly reclined. You can even have your massage therapist use pillows to help support your body as you’re receiving the massage. Since fluid buildup in the uterus may cause discomfort, including digestive issues or heartburn and a massage can be beneficial for pregnant women. Massage for prenatal women is also helpful in easing the stress that often accompany pregnancy.\nMassage during pregnancy offers many benefits, including a reduction in stress. Massage can help relax the body and mind and is generally beneficial in promoting better sleep. Massages during pregnancy can be safe and effective. But, you must consult your physician prior to beginning any new exercise. Massage therapists aren’t all trained to assist pregnant women. You can always inquire with the establishment where your baby is being delivered if you are unsure whether this type of massage is safe.\nResearch suggests that perinatal experts recommend achieving deep relaxation during the final six to eight weeks of pregnancy, which is the duration of the majority of massage therapy sessions. Women who are relaxed have lower blood pressure and a steady blood flow to the uterus, placenta and uterus and uterus as well as a more stable and functional immune system. They feel less anxious and fearful. Massage can also aid women in learning relaxation techniques to help cope with stressful situations. Massage is beneficial for couples because it supports their positive moods.", "label": "No"}
{"text": "Day 5: Consume cabbage soup, six tomatoes, and 565 grams of meat on your fifth day (or a substitute for beef, such as pork, fish, or chicken). Day 6: Eat cabbage soup, as many vegetables as you want but no potatoes, and as much meat as you want (or another protein option). During the seventh day, have cabbage soup, sugar-free fruit juice, and brown rice.\nWhat is the maximum amount of weight you can lose with cabbage soup?\n- The Cabbage Soup Diet is a short-term weight-loss diet that includes cabbage soup. As the name indicates, it entails consuming copious amounts of cabbage soup. However, numerous health professionals advise that the diet is dangerous and that the effects are not long-lasting.\n- 1 What happens if you eat cabbage soup for a week?\n- 2 Can I eat eggs on cabbage soup diet?\n- 3 How long can you do the cabbage diet for?\n- 4 How many calories are in a bowl of cabbage soup?\n- 5 What snacks can I eat on the cabbage soup diet?\n- 6 What do you do after the cabbage soup diet?\n- 7 Does Cabbage Soup Diet make you poop?\n- 8 Can you drink alcohol on the cabbage soup diet?\n- 9 How long does cabbage soup last in the fridge?\n- 10 How does cabbage soup make you lose weight?\n- 11 How does fat flush soup work?\n- 12 Is cabbage good for belly fat?\n- 13 Does cabbage detox the body?\n- 14 Is cabbage good for weight loss?\nWhat happens if you eat cabbage soup for a week?\nIt is recommended that you follow the Cabbage Soup Diet for only a limited period of time. It entails consuming copious amounts of cabbage soup, as the name indicates. While supporters of the diet claim that it may help you lose up to 10 pounds (4.5 kg) in a single week, many health professionals caution that the diet is dangerous and that the results are unsustainable.\nCan I eat eggs on cabbage soup diet?\nConsume a sufficient amount of protein, fats, and veggies. Protein-rich foods such as meat, fish, eggs, tofu, quinoa, and buckwheat help you retain muscle while also keeping you feeling satisfied for extended periods of time.\nHow long can you do the cabbage diet for?\nThe cabbage soup diet is a low-fat, high-fiber diet that lasts for a total of seven days and is exceptionally effective. While the diet is mostly comprised of cabbage soup, it does include some other vegetables such as potatoes and tomatoes to round out the nutritional profile. Meats and unsweetened teas and coffees are also acceptable as beverages.\nHow many calories are in a bowl of cabbage soup?\nCabbage soup (one cup) includes 14.9 grams of total carbohydrates, 11.9 grams of net carbohydrates, 2 grams of fat, 4.2 grams of protein, and 89 calories.\nWhat snacks can I eat on the cabbage soup diet?\nWhat You Can Consume\n- Food for Day 1: Fruit, with the exception of bananas\n- Food for Day 2: Vegetables such as leafy greens (not starchy), but no fruit. Today’s menu includes fruits and vegetables. Meat (or cooked chicken without the skin) and tomatoes on day four\n- beef and vegetables on day five\n- brown rice, unsweetened fruit juices on day six\n- beef and vegetables on day seven\n- beef and vegetables on day eight\nWhat do you do after the cabbage soup diet?\nIt is not recommended by any health authority to adopt the diet. In addition, proponents of the cabbage soup diet urge individuals to refrain from exercising while on the diet. Getting enough exercise, on the other hand, is extremely vital for general health. Exercise on a regular basis is also considerably more likely to result in significant, long-term weight loss.\nDoes Cabbage Soup Diet make you poop?\nCabbage also has a high amount of fiber, which is beneficial for weight reduction since it keeps you feeling full longer. Because of the nutritional fiber in the soup, it may be beneficial in lowering cholesterol and alleviating constipation.\nCan you drink alcohol on the cabbage soup diet?\nWhat beverages may I have while on the cabbage soup diet? It permits the use of water, coffee, and unsweetened herbal tea – but not alcoholic beverages or sodas.\nHow long does cabbage soup last in the fridge?\nWhen refrigerated, this soup will last for approximately five days and may be reheated in the microwave or on the stovetop. Additionally, the soup may be frozen for up to three months.\nHow does cabbage soup make you lose weight?\nThe goal of the cabbage soup diet is to reduce your calorie consumption by drastically reducing your food intake. In addition, Rothenberg notes that the low-calorie diet, along with the high fiber content of the filling vegetables, fruit, and cabbage, encourages people to go to the toilet more frequently than they would otherwise.\nHow does fat flush soup work?\nIt is filled with nutritious powerhouses such as sweet potato, spinach, garlic, carrots and tomatoes, and it genuinely flushes the fat away by restoring the body’s acid-alkaline and sodium-potassium balance to the body’s organs and glands, which helps to burn calories more effectively.\nIs cabbage good for belly fat?\nDietary fiber with cabbage juice for weight reduction | Cabbage juice helps you lose weight and burn fat. In addition to being high in dietary fiber, cabbage juice might help you feel fuller for longer periods of time, avoiding cravings and hunger pains. This further minimizes the likelihood of consuming an excessive amount of calories.\nDoes cabbage detox the body?\nsulforaphane, found in most cruciferous vegetables (including broccoli and sprouts), helps the body fight against toxins. Sulforaphane is found in cabbage, as well as most other cruciferous vegetables. Cabbage also provides the body with glutathione, which is an antioxidant that aids in the improvement of the liver’s detoxification function.\nIs cabbage good for weight loss?\nCabbage is also beneficial for weight loss and maintaining youthful skin. A cup of boiled cabbage has only 33 calories and is low in fat and high in fiber, making it a healthy snack option. Cabbage also has antioxidant properties that assist to keep skin looking healthy, toned, blemish-free, and bright; it is a good source of vitamin C. (including vitamin C and beta-carotene).", "label": "No"}
{"text": "The Great Highway is a road which runs from Shan on the Desert, across the northern edge of the Small Kingdoms, to the Hegemony of the Three Ethshars. The Inn at the Bridge is so called because it is within a short walk from the bridge where the highway crosses the Great River, a few leagues west of the border between the Small Kingdoms and the Hegemony. This notable inn also sits at a crossroads where travelers either head south a day to Ethshar of the Spices, or continue northwest on the longer trek to either of the other two Ethshars or to the Baronies of Sardiron.\nLeaving Shan on the Desert, the Great Highway passes through the Small Kingdoms of Dhwerra, Sinodita, Angarossa, Yondra, Amramion, Hlimora, Urduron, Ophera, Krithimion, Bugoa, Syndisha, Tuyoa, Shesta, and Lamum before crossing over into the Hegemony. At one point the Great Highway passed through Mezgalon rather than Bugoa, which was a straighter path, but at some point between 5180 and 5222 the route was changed.", "label": "No"}
{"text": "Catching breast cancer early can facilitate easier and more successful treatment. It’s important to undergo regular mammograms and exams from your breast cancer care provider. However, there are also procedures you can do at home to check for signs of breast cancer.\nThis video provides instructions on performing at-home breast cancer checkups. You’ll receive instructions on what movements and positions to perform during a visual exam. By completing a visual exam, you can look for signs of abnormal shape, symmetry, color, and puckering.\nIf you notice any signs of cancer during an at-home exam, contact your breast cancer care provider immediately. At the Boca Raton office of Marla W. Dudak, MD, we use the latest technology and medical information to provide accurate and timely diagnoses, treatment, and care. Call us today at (888) 418-6759.", "label": "No"}
{"text": "Where should a dog bowl be placed in the house?\nDogs can be very messy eaters, spilling food all around the floor and even on the walls, so make sure there’s nothing near your dog’s eating area that can be damaged. We recommend putting his food bowl near his water bowl, which should always be there, cleaned often and filled with fresh water.\nAre standing dog bowls better?\nHaving your dog’s bowl higher off the ground puts less strain on your dog’s neck. So if your dog is older or struggles with joint or bone issues, elevated bowls are a great way to make them comfortable when they eat. If you have a large or giant breed dog, elevated bowls aren’t going to be the best fit.\nAre elevated water bowls good for dogs?\nMaybe you’ve even heard some of the benefits of raised feeders. They can be great for older dogs, because there’s less strain on the neck, hips, shoulders and joints. They can keep the feeding area cleaner by preventing your dog from spilling or pushing their bowl around the floor.\nWhy do raised bowls cause bloat?\nThe twisting prevents release of the gas, putting pressure on other organs, and restricting proper blood flow to and from vital parts of the body. Bloat can occur very rapidly in dogs and requires immediate medical attention.\nShould dogs eat in the kitchen?\nDon’t feed your dog in the kitchen. If possible, you should avoid feeding your dog in the kitchen. Dry pet food, treats, and supplements can be prone to contamination with Salmonella, which can make both pets and people sick.\nShould I put my dogs food on the floor?\nFloor dog feeders make excellent choices for smaller dog breeds. Since the dog needs to bend his head and neck in order to reach his meal, floor-level bowls work better for petite pooches. Moreover, floor-level bowls eliminate the mess that often accompanies elevated dog dishes.\nWhy do elevated dog bowls cause bloat?\nWhen should you use an elevated dog bowl?\n- Elevated dog bowls (or “raised dog bowls”) come in many different shapes, sizes, and styles.\n- The primary benefit of a raised dog bowl is that it can make it easier for your dog to eat.\n- Consider raised dog dishes when looking for dog bowls for older dogs as well as pets with arthritic or orthopedic issues.\nWhy do I have to hand feed my dog?\nHand feeding can help a dog who is already a resource guarder and help prevent a dog from resource guarding. By only feeding your dog from your hand, you show her that you are the gateway to valuable things and when you reach into her space it means food.\nAre slanted dog bowls better?\nA slanted bowl prevents food sticking around the bottom rim of conventional bowl where dog/cat can’t get it. What’s more, it enabled your cat / dog to eat easier as the bowl is on an slanted angle, aiding your pet’s digestion in the process.\nShould dogs be fed morning or night?\nMost adult dogs should have two meals a day – one in the morning and one in the evening. However, if you have a particularly small or big dog, read on… Small breeds Toy dogs and small breed dogs typically have fast metabolisms, which means they burn energy more quickly than larger dogs.\nWhat time of day should you feed your dog?\nYou can feed your dog one or two times a day. It’s best to do it twice daily at 8-12 hour intervals.\nAre tilted bowls good for dogs?\nShould small dogs eat from elevated bowls?\nRaised dog food bowls, which are also commonly known as elevated feeders, are typically not needed for pets, according to veterinarian Jon Gellar. Not only do dogs generally not need to eat from bowls that are raised high off the floor, these feeders are in some cases thought to be detrimental to them.\nDo dogs need a tilted bowl?", "label": "No"}
{"text": "Beauty, Wellness, Recipes, Food\nI have to break it to you. What you eat is the biggest determiner of your health. I am writing from St. Louis, my hometown. I am immersed in my gene pool. Those younger than me, older than me, and my age. Everyone has a disease or condition.\nI was shocked by how my younger brother has changed in appearance so drastically. My younger sister’s response was, “Well, we are all getting older - it’s only you who’s aging in reverse.” Wow! My sister is 25 and two years ago started experiencing health problems she shouldn’t have at her age.\nThe big difference - diet. No toxic dump next door; my family members all live in desirable St. Louis suburban neighborhoods.\nFood is medicine. It is youthfulness. It is health. It is more important than your gene pool, exercise habits, or weight. The only difference between me and my family is food. They eat a regular American diet. I eat a plant based diet.\nPlant based, for me, doesn’t mean vegetarian. Plant based is that the majority of what I eat is either a vegetable, fruit, or plant fat like olives, coconut, or avocado. Meat and dairy are extras and grains are a garnish.\nWhat have I escaped eating this way? Inflammation, autoimmune disease, diabetes, high blood pressure, digestive disorders, skin conditions. Based on my visit, It’s all in the gene pool.\nYou want to be healthy, you want to glow? Eat more plants.\nExplore the amazing effect a plant based diet can have in the ELEVATE program.\nWords to Live By\nI am not a heroine, but I have chosen the person I want to be.", "label": "No"}
{"text": "Here's a list of over 30 science fair ideas to get you started then download science experiments, and watch experiment videos to inspire your project. Science trivia for kids have fun with our science trivia and science quizzes for kids our science trivia, science jokes and science experiments for. Ask questions and get answers from people sharing their experience with physical science. Looking for top 8th grade science quizzes play 8th grade science quizzes on proprofs, the most popular quiz resource choose one of the thousands addictive 8th grade science quizzes, play and share.\nScience is both a body of knowledge and a process in school, science may sometimes seem like a collection of isolated and static facts listed in a textbook, but that's only a small part of the story. Science is all about asking questions, and some of the most interesting and thought provoking questions come from the imaginations of children. Ask questions, get answers, help others and connect with people who have similar interests. General science: content knowledge (5435) test at a glance test code 5435 time 25 hours number of questions 135 format selected-response questions.\nTest your knowledge with amazing and interesting facts, trivia, quizzes, and brain teaser games on mentalflosscom. Science is perhaps one of the most and turned it into our fantabulous science quizzes that are yawn-proof for into quick fire questions,. 7491 quotes have been tagged as science: albert einstein: ‘two things are infinite: the universe and human stupidity and i'm not sure about the universe.Visit this site for our questions to science quiz one our questions to science quiz one are suitable for the family or pub quizzes or bar quizzes free questions to science quiz one. Get 120 data science interview questions about product metrics, programming, statstics, data analysis, and more. The purpose of the paper what are the most important research questions in my is this research at the cutting edge of science or is it in an area that is. Science journal special project for its 125th anniversary: top 25 questions and 100 more list of links to unsolved problems in physics,. Gcse science quiz it's nearly time for gcse results, but how would you do if you sat the science exam try our quiz questions are from bbc bitesize and based on the knowledge required by gcse syllabuses, as actual questions are. This is the general knowledge questions and answers section on general science with explanation for various interview, competitive examination and entrance test. Science jeopardy the scientific study of life biochemistry and bonding essential molecules the cell and its enter all answers and questions in the normal view. Tm science practice test fp1 this is a test of your skills in analyzing science information questions 1 through 5 are based on the information below.\nLatest science news, comment and analysis from the guardian, the world's leading liberal voice. The ask an expert forum is intended to be a place where students can go to find answers to science questions that they have been unable to find using other resources. Seven sets of free the act science practice test questions that you can use to familiarize yourself with the test instructions and format.\nScience bowl biology biology - 3 biol-91 short answer: in biology, what is the word used to describe the appearance of an individual without. A list of questions you can use to generate conversations in the esl/efl classroom. Science questions and answers from chegg science can be a difficult subject for many students, but luckily we’re here to help our science question and answer board features hundreds of science experts waiting to provide answers to your questions. Xem video a new survey on scientific literacy from the center for accountability in science found that most respondents failed to correctly answer questions designed for a fifth-grade science class.\nThe 20 big questions in science from the nature of the universe (that's if there is only one) to the purpose of dreams, there are lots of things we still don't know. Open problems in science this page will build a list of open research questions at the so-called bleeding edge of science this page. Science projectcalling all science fans we have the top trivia quizzes around to test your science acumen it’s time to strap on the lab coats and adjust your safety goggles, and dive right into the best trivia quizzes around. Official homepage for science watch full episodes free with your tv subscription get behind the scenes with your favorite shows start exploring now.", "label": "No"}
{"text": "We've made it easier and more convenient than ever to find just the right doctor for you and your family.\nAnesthesiologists administer drugs that render the patient insensitive to pain during surgery and other painful procedures. They also contribute to monitoring patients' life functions and in managing problems in cardiac and respiratory resuscitation. In addition, they are actively involved in diagnosis and treatment of acute and chronic pain.\nThese physicians specialize in procedures that decreases the size of the stomach, including Lap Band and Gastric By-Pass procedures. The purpose is to limit food intake, which therefore enables the person to lose a significant amount of weight. These procedures are performed at Marshall Medical North, certified as a Bariatric Surgery Center of Excellence.\nThese physicians specialize in diagnosing and treating heart problems and diseases of the heart including vascular disease, hypertension, congestive heart failure and other blood vessel diseases. Cardiologists also provide evaluations of chest pain with treadmills, stress tests, echocardiography, thallium stress tests, holter monitoring as well as blood pressure monitoring.\nDermatologists specialize in diagnosis and treatment of hair and nail disorders, diseases of the skin, skin cancer surgery and allergic diseases.\nEar, Nose & Throat (Otolaryngologists)\nThese physicians are specially trained in medicine and surgery of the ears, nose and throat. This practice also includes treatment of hearing problems, nasal allergies, sinus problems, head and neck surgery and facial plastic surgery.\nThis physician is specially trained to treat patients with conditions requiring immediate medical care such as sudden illness or trauma.\nFamily Practice physicians diagnose primary illnesses or diseases and treat patients with nonsurgical as well as surgical methods. They deal in preventive medicine by providing physicals and check-ups for the maintenance of good health. Some of these physicians also perform obstetrical and gynecological services and care for newborns as well as older children and adults.\nThese physicians use surgical methods to diagnose and treat illnesses, injuries and diseases. Surgeons also perform endoscopy, i.e., colonoscopy, gastroscopy and remove colonic polyps.\nThese specialists offer a type of care as well as a philosophy of care that focuses on the palliation of a chronically ill, terminally ill or seriously ill patient's pain and symptoms, and attending to their emotional and spiritual needs.\nThese physicians treat adults with chronic illnesses including diabetes, high blood pressure, emphysema and other pulmonary diseases. They also treat gastrointestinal tract diseases, liver disease, disease associated with stroke and some neurological diseases. They may perform a variety of procedures such as gastroscopy, proctoscopy, flexible sigmoidoscopy and pulmonary function studies. They are available for consulting in any of the above areas.\nThis physician provides and coordinates cancer treatment, including chemotherapy, other medical therapy or arrangement for surgery or radiation treatment.\nThis physician is skilled in the diagnosis and treatment of diseases of the nervous system.\nObstetrician/Gynecologists are physicians who have the special knowledge and skills to provide medical and surgical care of the female reproductive system and associated disorders. They care for and treat women during pregnancy, in childbirth and after a baby is born. They also treat diseases of the genital tract in women, provide preventive cancer tests such as pap smears and breast exams, and diagnose and treat various infertility problems.\nOphthalmologists specialize in diagnosis as well as medical/surgical treatment of diseases of the eyes and related areas to include refractive defects of the eyes.\nThese physicians specialize in treatment of musculoskeletal problems which include injuries and diseases of the spine, bones and joints as well as the extremities, tendons, muscles and nerves. They are concerned with preserving and restoring the proper functioning of these areas of the body.\nThis physician specializes in the treatment of pain as a result of cancer, shingles, headaches, nerve injury, poor circulation, arthritis, disc disease and surgery. He also treats neck, back, arm, leg, facial and rib pain.\nA multidisciplinary approach to specialized medical care for people with serious illnesses. It focuses on providing patients with relief from the symptoms, pain, physical stress, and mental stress of a serious illness—whatever the diagnosis.\nPathologists provide results of diagnostic examinations of tissue removed at surgery enabling the attending physician to properly treat patients. Tests are performed on various body fluids by the pathologist and the data are reported to the patient's physician to assist in proper treatment of the patient.\nThese specialists are associated with the develop-ment, care and treatment of childhood diseases from newborn to adolescence. They also deal with the pre-vention of childhood disease through administration of planned immunizations and well-baby/child check-ups.\nPlastic surgeons offer comprehensive care for patients sustaining traumatic facial injuries, upper extremity and head injuries, and complex lower extremity injuries. They also treat congenital deformities including cleft lip and palate, craniofacial anomalies, congenital hand deformities, burn reconstruction, cosmetic and reconstructive breast surgery and aesthetic surgery.\nThis physician is specially trained in diagnosing and treating mental illness. This practice includes treatment of depression, anxiety, nervous disorders, behavioral problems, substance abuse, eating disorders and psychotic disorders. A psychiatrist also is available for consultation and assistance for people that are being emotionally affected by chronic illness or losses.\nA pulmonologist evaluates and treats all diseases of the lungs and respiratory system. This physician also performs pulmonary function studies and invasive diagnostic procedures, including bronchoscopy.\nThis physician provides cancer treatment by means of x-rays or radioactive substances.\nRheumatology is a subspecialty of internal medicine devoted to patient care in the areas of arthritis and autoimmune disease, which affect nearly 20 percent of the American population. There are more than 200 types of autoimmune diseases including rheumatoid arthritis, osteoarthritis, gout, lupus, back pain, osteoporosis and tendinitis.\nRadiologists are physicians who use radiant energy and substances to photograph parts of the body. The results aid physicians in diagnosing and treating medical conditions.\nThese physicians concern themselves with the scientific, clinical and surgical aspects of the urinary tract in both males and females. In addition, they treat diseases in the genital organs of men. Through routine visits, men and women can identify or stop at an early stage cancer of the kidney, bladder and other urologic organs, including the prostate in men.", "label": "No"}
{"text": "2. \"one of the ... most toxic space derelicts ever to crash to Earth\"\nI wonder what sort of toxicity is being referred to here.\nThe spacecraft does contain a few ounces of plutonium, which might be dispersed in the air, or it might survive the trip through the atmosphere and contaminate the land or water where the parts of the spacecraft end up.\nThere are also tons of ordinary liquid rocket fuel & oxidizer; these chemicals are often described as toxic, but they probably burned up in the atmosphere.", "label": "No"}
{"text": "You can use any of the best steroids to get ripped.If your target is to build muscle mass, there are also steroids that you can use for this purpose.The first steroid that comes to mind when you think muscle building steroids is Dianabol. This steroid is anabolic and will promote muscle growth. Dianabol does not have a huge dose, as it is a rather potent steroid, best steroid to build muscle.Another popular steroid used to bulk up and gain muscle is Nandrolone, best steroid to build muscle. This steroid does not have a huge dose, since you can get a dose of 10mg every other day. However, the strength of this steroid, besides its high cost, is that this steroid is non-stimulatory and will not affect metabolism (like a high dose of other anabolic steroids), best steroid cycle for lean muscle gain. It is also non-irritating and will not increase your appetite or lead to weight gain, best steroids online forum.In this section I will introduce you to the most popular steroids with the most benefits and side effects, best steroids online forum.I hope by reading this section, you will be more motivated to use the steroids that you will see as a main part of gaining muscle mass, best steroids online forum. I have included some of the best steroids here, and most of them are very low cost.Before continuing, you should know the main reasons why taking steroids.It all starts with an overabundance of testosterone. Too much and the effects of steroids are much worse. In the body, overproduction of testosterone can cause a lot of issues in terms of libido, and in this section, I'll cover what causes this as well as some solutions that you can consider to get rid of this issue, to steroids muscle fast best build.This is the most obvious reason why you want to take the steroids, to steroids muscle fast best build. When you take these steroids your body would have a constant and unending flow of testosterone into the system, best steroids to get big quick. While many will say that this hormone is not an essential part of steroid metabolism, there was no way that it would be.The hormones that cause these effects are calledandThese hormones are responsible for producing testosterone. And while testosterone is the most common hormone produced during sex, both cortisol (stress hormone) and cortisol are also released during sex, and these cortisol hormones play an important role in libido and in keeping the body healthy, best steroids stack for lean muscle. In this section, I'll describe how you can reduce some of the stress and boost your sex drives.Cortisol and cortisol are both hormone that produce anabolism in the body. The main hormone that is released during anabolism, and in excess, is. A good supply of cortisol can help in enhancing the production of testosterone in the body, best steroids to build muscle fast.The biggest problem with over production of this hormone is that it decreases the body's production of other hormones, best steroids to build muscle fast.\nBest steroid cycle for muscle gain\nUser: best steroid cycle to gain muscle and lose fat, best steroid for gaining muscle and cuttingfat, best for building muscle and for losing fat.Body composition: lean muscle-weight, fat-mass, muscle-percentage, best pill steroid to take.Mens body: arms-legs, legs-hands, abdomen-neck, thighs-shoulders, back-waist, body-fat%Women body: arms-legs, legs-hands, abs-back, thighs-shoulders, back-waist, body-fat%What is the best steroid cycle to gain muscle and get stronger, best steroid stacks for bulking?Here's a good question. The answer is: the best is best, are steroids for bodybuilding dangerous. This is because bodyweight (bodyweight, pounds) and bodyfat% (muscle-fat, grams) directly relate to bodyweight and bodyfat%, which in turn relate to strength and muscle gain, respectively.Bodyweight refers to the muscle-weight, or muscle-weight that you can see or use in the mirror, muscle for gain cycle best steroid. Bodyfat% refers to the bodyfat percentage a person is in: a percentage of body fat.What is the best steroid to lose fat, best steroids to build muscle and burn fat?The answer is: the best is best, top 5 steroids labs.Fats and Carbs (F/C) refers to the ratio of fats and carbs within a given caloric package. When people eat a high-calorie, high-fat or low-calorie intake, they often experience a decline in their bodyfat percentage, bodyfat% and weight gain. But what does this mean, anabolic steroids to lean out? The answer is: when you are eating food with a high to low proportion of calories that you can eat, these nutrients are most likely to be broken down into these F/C ratios (see Table 1), best steroid cycle for muscle gain. That's because it is very difficult or impossible to absorb F/C from food that is full of F/C. On the other hand, when you are eating food that is low in calories that is full of F/C, the F/C will be removed, what are the best cutting steroids.So how much F/C do you eat per day? That depends on your age, do oral steroids work for bodybuilding0. A normal adult bodyweight (weight in kilograms divided by height in meters squared) is roughly 135 pounds. For comparison, a man who is six feet tall and weighs 270 pounds eats an average of about 4,800 calories per day – or about two and a half times per day that he would have consumed if he was an extremely lean person, or an extremely muscular person.\nBodybuilders rarely seek treatment when affected by steroid use, partly why data on steroid use in bodybuilding is scarce. Some of the most severe cases occur in those with low muscle mass such as those with bodybuilders who use very high dose testosterone injections or those with an inborn deficiency of testosterone such as dihydrotestosterone, a naturally-occurring \"crisis\" substance in certain athletes.Why Steroids Can Cause Hair LossThe main reason for using steroids as part of bodybuilding is the body's production of an enzyme that makes testosterone. The body can either convert testosterone directly into estrogen or it can convert it to dihydrotestosterone. The former is much higher in women and is the steroid that causes most of the side effects in women who use testosterone supplements.The reason dihydrotestosterone is so much higher in women than in men is because women have a genetic defect in converting testosterone to estradiol. Women who are already deficient will have very low estrogen levels even if they take the equivalent amount of testosterone in a day.Testosterone levels in women are actually about three times higher than they are in men. Testosterone and the male hormone estrogen will make a woman's natural breast tissue grow, but the female body has an enzyme that breaks down testosterone into estrogen. Most women don't ever experience signs or symptoms of sexual dysfunction as a result of the effects of the male hormone. This means that women are generally not prone to the physical side effects associated with using steroids. One of the more obvious ones is hair loss.Why it May HappenTestosterone, like its male counterpart, makes hair grow on the scalp and scalp hair is a valuable commodity due to our daily desire for it in the form of make-up. However, testosterone also causes hair loss on the scalp. If too much of the hormone (or its precursor) gets into hair follicles, a buildup of testosterone causes hair to fall out as well as eventually causing hair to come in and out throughout the day. This process can be likened to a domino effect: if the hormone is left too long in follicles, an explosion is likely.Tests that look for signs of damage to the prostate and to other hormones in the body will likely indicate damage to hair follicles, or that the level of one's hormones is higher than normal. Men who use steroids are also at heightened risk for certain breast cancers. Hair loss also tends to happen in men under the age of 55. The hair itself is fairly resilient, but the follicles that hold the male hormone are susceptible to damage from excessiveRelated Article:", "label": "No"}
{"text": "Calgary is home to many birds, some of which can be a nuisance like pigeons, starlings, sparrows and magpies. Bird nests can clog gutters, downspouts and vents, and their acidic droppings can deface your home or business and harm your health.\nPoulin’s Pest Control in Calgary carries a variety of deterrents to prevent birds from making your property home. However, relocating them may be the only option if the flock is large and resilient. Fortunately, our technicians specialize in humanely removing birds from your property. Contact us at our Calgary location today to learn more about our products and services.\n4 signs you have a bird problem\nHere are four telltale signs you have a bird infestation on your property.\n- You notice large groups of birds. If you spot several birds hanging around your property, keep an eye on them. If their numbers increase, you may have a bird problem on your hands.\n- You see excessive droppings. Large amounts of bird feces around your property are a clear sign of an infestation.\n- You find feathers and nesting materials. If you have a bird problem, you may notice nesting materials like twigs, straw, leaves and feathers in your eaves and gutters. You may also see damage to these areas.\n- You hear loud noises. Birds are noisy, especially in large numbers. Therefore, if you hear cries and shrieks that can’t be ignored, you may have a bird problem. Additionally, bird noises coming from inside your attic are a red flag.\nThe best way to prevent birds from nesting around your property is to be proactive by eliminating food and water sources, covering outdoor garbage containers, and sealing and repairing vents and openings.\nYou can also install effective and humane bird deterrents to prevent birds from being enticed by your property. At Poulin’s Pest Control in Calgary, we carry various bird control devices and deterrents, such as netting, spikes and electronic repellents.\nLarge flocks of birds aren’t only noisy and destructive; they’re unhygienic and pose health threats to humans and pets. Therefore, removal is often the best way to get rid of them and keep them away.\nOnce a Poulin’s technician determines that you have a bird problem, they’ll locate the nests and entry points. After that, they’ll remove nesting materials. Poulin’s Pest Control is committed to the humane treatment of animals. Therefore, we ensure no animals are harmed during our removal process.\nThe technician will then clear and clean any contaminated material, like droppings, which can pose serious health risks. To prevent future bird infestations, they’ll also screen and seal any entry points and install repellents.\nOur technicians are trained to deal with the most challenging situations and will ensure your bird problem doesn’t come back.\nFrequently Asked Questions:\n1. If the birds aren’t causing damage, can they stay?\nEven if you don’t see immediate damage to your property, birds carry diseases and parasites that can harm humans, pets and livestock. Their droppings can also damage your property and cause slips and falls. Therefore, it’s important to get rid of pest birds as soon as possible.\n2. Can I remove pest birds on my own?\nYou can install bird repellants on your own. However, you should never attempt bird removal. Hiring a professional service like Poulin’s Pest Control to remove and relocate them will prevent the birds from being harmed and ensure regulatory restrictions are followed.\n3. When are pest bird infestations most common?\nIn Calgary, pest birds often cause the most problems between April and August. However, some are active all year round.\nBird removal and control in Calgary\nIf you have a bird problem at your home or business, Poulin’s Pest Control team in Calgary can help. We carry a wide variety of bird deterrents and offer bird removal and control options to address seasonal bird activity in your area. We also provide proactive preventative maintenance plans to ensure long-term pest-free results. Contact us in Calgary today for expert advice or to book an inspection.", "label": "No"}
{"text": "Join us in the upliftment and freedom of the Feather Tribe with this beautiful unique hand-carved Flower of Life Eagle Down Feather.\nThe Flower of Life is one of the basic sacred geometry shapes. The Flower of Life symbolizes creation and reminds us of the unity of everything.\nIn the stories of some cultures, the down feathers of an eagle were important gifts given by the bird to the hero. These powerful necklaces promote inner strength, growth and bravery.\n░≡««☼»»≡░ Size & Material ░≡««☼»»≡░\n6 cm x 3 cm\nPremium Black Cord", "label": "No"}
{"text": "Introduction:-A neuron is an information-processing unit that is fundamental to the operation of a neural network. The model of a neuron, which forms the basis for designing neural networks. Here we identify three basic elements of the neuronal model:-\n1. A set of synapses or connecting links, each of which is characterized by a weight or strength of its own. Specifically, a signal Xj a t the input of synapse j connected to neuron k is multiplied by the synaptic weight wkj\" It is important to make a note of the manner in which the subscripts of the synap tic weight wkj are written. The first subscript refers to the neuron in ques tion and the second subscrip t refers to the input end of the synapse to which the weight refers. Unlike a synapse in the brain, the synaptic weight of an artificial neuron may lie in a range that includes negative as well as positive values.\n2.An adder for summing the input signals, weighted by the respective synapses of the neuron; the operations described here constitute a linear combiner.\n3. An activation function for limiting the amplitude of the output of a neuron. The activation function is also referred to as a squashing function in that it squashes the permissible amplitude range of the output signal to some finite value.\nTypically, the normalized amplitude range of the output of a neuron is written as the closed unit interval [0, 1] or alternatively [- 1, 1]. The neuronal model also includes an externally applied bias, denoted by bk.The bias bk has the effect of increasing or lowering the net input of the activation function,depending on whether it is positive or negative, respectively.In mathematical terms, we may describe a neuron k by writing the following pair of equations:\nWhere the input signals are\\are the synaptic weights of neuron k; Ukis the linear combiner output due to the input signals; bkis the bias;is the activation function; and Ykis the output signal of the neuron. The use of bias bkhas the effect of applying an affine transformation to the output Ukof the linear combiner depends on whether the bias bk is positive or negative, the relationshipbetween the induced local field or activation potential Vk of neuron k and the linear combiner output Uk is modified; hereafter the term \"induced local field\" is used. Note that as a result of this affine transformation, the graph of Vk versus Uk no longer passes through the origin.\nThe bias bk is an external parameter of artificial neuron k. We may account for its\nIn particular, depending on whether the bias bk is positive or negative, the relationship between the induced local field or activation potential Vkof neuron k and the linear combiner output Ukis modified in the manner; hereafter the term \"induced local field\" is used. Note that as a result of this affine transformation, the graph of Vkversus Ukno longer passes through the origin. The bias bkis an external parameter of artificial neuron k. We may account for its presence as in Eq. (1.2). Equivalently, we may formulate the combination of Eqs. (1.1)to (1.3) as follows:\nIn Eq. (1.4) we have added a new synapse. Its input is\nAnd its weight is,", "label": "No"}
{"text": "As autumn gives way to winter here are a few autumnal photos taken around the park in early November.\nIf you have any photos of interest to park visitors please do send them to us for display here.\n(Pictures courtesy of Will Davis/Mike Davis)\nSome pictures taken on a recent walk across the western side of the park. It’s currently closed to the public, but the friends group leads guided walks that take in the western half of the park, usually monthly. Contact us to book a place, the walk also includes a visit to the Great Oak.\nPictures by Will Davis.\nAn early morning mist across the park on November 1st, by Rab Harley:", "label": "No"}
{"text": "Let's grow up some fishes in the sea. You can play up to three player and eat fishes in the sea. Try to grow up your fish as much as you can and try to get the highest score you can.\nMove: \"ARROW KEYS\"\nMove: \"MOUSE\" and \"LEFT-CLICK\"", "label": "No"}
{"text": "Device quantity: 22 sets\nProject introduction: A large number of lotus tanks are placed underwater on the surface of Beijing Houhai Lake. In order to prevent the large porcelain tanks from freezing and cracking underwater in winter, 22 sets of MDD are installed along the west coast to prevent freezing on the water surface. Up to ten of thousands of square meters. Due to the arrival of wild animals, a large number of citizens are attracted to stop and visit.", "label": "No"}
{"text": "An experimental study is performed to measure the terminal settling velocities of spherical particles in surfactant based shear thinning viscoelastic (VES) fluids. The measurements are made for particles settling in unbounded fluids and fluids between parallel walls. VES fluids over a wide range of rheological properties are prepared and rheologically characterized. The rheological characterization involves steady shear-viscosity and dynamic oscillatory-shear measurements to quantify the viscous and elastic properties respectively. The settling velocities under unbounded conditions are measured in beakers having diameters at least 25x the diameter of particles. For measuring settling velocities between parallel walls, two experimental cells with different wall spacing are constructed. Spherical particles of varying sizes are gently dropped in the fluids and allowed to settle. The process is recorded with a high resolution video camera and the trajectory of the particle is recorded using image analysis software. Terminal settling velocities are calculated from the data.\nThe impact of elasticity on settling velocity in unbounded fluids is quantified by comparing the experimental settling velocity to the settling velocity calculated by the inelastic drag predictions of Renaud et al.1 Results show that elasticity of fluids can increase or decrease the settling velocity. The magnitude of reduction/increase is a function of the rheological properties of the fluids and properties of particles. Confining walls are observed to cause a retardation effect on settling and the retardation is measured in terms of wall factors.\n22 Related JoVE Articles!\nFast Imaging Technique to Study Drop Impact Dynamics of Non-Newtonian Fluids\nInstitutions: The University of Chicago, The University of Chicago, Yale University.\nIn the field of fluid mechanics, many dynamical processes not only occur over a very short time interval but also require high spatial resolution for detailed observation, scenarios that make it challenging to observe with conventional imaging systems. One of these is the drop impact of liquids, which usually happens within one tenth of millisecond. To tackle this challenge, a fast imaging technique is introduced that combines a high-speed camera (capable of up to one million frames per second) with a macro lens with long working distance to bring the spatial resolution of the image down to 10 µm/pixel. The imaging technique enables precise measurement of relevant fluid dynamic quantities, such as the flow field, the spreading distance and the splashing speed, from analysis of the recorded video. To demonstrate the capabilities of this visualization system, the impact dynamics when droplets of non-Newtonian fluids impinge on a flat hard surface are characterized. Two situations are considered: for oxidized liquid metal droplets we focus on the spreading behavior, and for densely packed suspensions we determine the onset of splashing. More generally, the combination of high temporal and spatial imaging resolution introduced here offers advantages for studying fast dynamics across a wide range of microscale phenomena.\nPhysics, Issue 85, fluid mechanics, fast camera, dense suspension, liquid metal, drop impact, splashing\nOptimize Flue Gas Settings to Promote Microalgae Growth in Photobioreactors via Computer Simulations\nInstitutions: Washington University in St. Louis, St. Louis, Wuhan University of China, Washington University in St. Louis.\nFlue gas from power plants can promote algal cultivation and reduce greenhouse gas emissions1\n. Microalgae not only capture solar energy more efficiently than plants3\n, but also synthesize advanced biofuels2-4\n. Generally, atmospheric CO2\nis not a sufficient source for supporting maximal algal growth5\n. On the other hand, the high concentrations of CO2\nin industrial exhaust gases have adverse effects on algal physiology. Consequently, both cultivation conditions (such as nutrients and light) and the control of the flue gas flow into the photo-bioreactors are important to develop an efficient “flue gas to algae” system. Researchers have proposed different photobioreactor configurations4,6\nand cultivation strategies7,8\nwith flue gas. Here, we present a protocol that demonstrates how to use models to predict the microalgal growth in response to flue gas settings. We perform both experimental illustration and model simulations to determine the favorable conditions for algal growth with flue gas. We develop a Monod-based model coupled with mass transfer and light intensity equations to simulate the microalgal growth in a homogenous photo-bioreactor. The model simulation compares algal growth and flue gas consumptions under different flue-gas settings. The model illustrates: 1) how algal growth is influenced by different volumetric mass transfer coefficients of CO2\n; 2) how we can find optimal CO2\nconcentration for algal growth via the dynamic optimization approach (DOA); 3) how we can design a rectangular on-off flue gas pulse to promote algal biomass growth and to reduce the usage of flue gas. On the experimental side, we present a protocol for growing Chlorella\nunder the flue gas (generated by natural gas combustion). The experimental results qualitatively validate the model predictions that the high frequency flue gas pulses can significantly improve algal cultivation.\nEnvironmental Sciences, Issue 80, Microbiology, Cellular Biology, Marine Biology, Primary Cell Culture, Chlorella, CO2, mass transfer, Monod model, On-off pulse, Simulink\nHigh Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices\nInstitutions: University of Wisconsin-Madison, University of Wisconsin-Madison.\nA novel microfluidic system has been developed that uses the phenomenon of passive pumping along with a user controlled droplet based fluid delivery system. Passive pumping is the phenomenon by which surface tension induced pressure differences drive fluid movement in closed channels. The automated fluid delivery system consists of a set of voltage controlled valves with micro-nozzles connected to a fluid reservoir and a control system. These voltage controlled valves offer a volumetrically precise way to deliver fluid droplets to the inlet of a microfluidic device in a high frequency manner. Based on the dimensions demonstrated in the current study example, the system is capable of flowing 4 milliliters per minute (through a 2.2mm by 260um cross-sectional channel). Based on these same channel dimensions, fluid exchange of a point inside the channel can be achieved in as little as eight milliseconds. It is observed that there is interplay between momentum of the system (imparted by a combination of the droplets created by the valves and the fluid velocity in the channel), and the surface tension of the liquid. Where momentum provides velocity to the fluid flow (or vice-versa), equilibration of surface tension at the inlet provides a sudden stop to any flow. This sudden stop allows the user to control the flow characteristics of the channel and opens the door for a variety of biological applications, ranging anywhere from reagent delivery to drug-cell studies. It is also observed that when nozzles are aimed at the inlet at shallow angles, the droplet momentum can cause additional interesting fluid phenomena, such as mixing of multiple droplets in the inlet.\nBiomedical Engineering, Issue 31, automated, passive pumping, microfluidic device, high speed, high flow rate\nMeasuring the Kinetics of mRNA Transcription in Single Living Cells\nInstitutions: Bar-Ilan University.\nThe transcriptional activity of RNA polymerase II (Pol II) is a dynamic process and therefore measuring the kinetics of the transcriptional process in vivo\nis of importance. Pol II kinetics have been measured using biochemical or molecular methods.1-3\nIn recent years, with the development of new visualization methods, it has become possible to follow transcription as it occurs in real time in single living cells.4\nHerein we describe how to perform analysis of Pol II elongation kinetics on a specific gene in living cells.5, 6\nUsing a cell line in which a specific gene locus (DNA), its mRNA product, and the final protein product can be fluorescently labeled and visualized in vivo\n, it is possible to detect the actual transcription of mRNAs on the gene of interest.7, 8\nThe mRNA is fluorescently tagged using the MS2 system for tagging mRNAs in vivo\n, where the 3'UTR of the mRNA transcripts contain 24 MS2 stem-loop repeats, which provide highly specific binding sites for the YFP-MS2 coat protein that labels the mRNA as it is transcribed.9\nTo monitor the kinetics of transcription we use the Fluorescence Recovery After Photobleaching (FRAP) method. By photobleaching the YFP-MS2-tagged nascent transcripts at the site of transcription and then following the recovery of this signal over time, we obtain the synthesis rate of the newly made mRNAs.5\nIn other words, YFP-MS2 fluorescence recovery reflects the generation of new MS2 stem-loops in the nascent transcripts and their binding by fluorescent free YFP-MS2 molecules entering from the surrounding nucleoplasm. The FRAP recovery curves are then analyzed using mathematical mechanistic models formalized by a series of differential equations, in order to retrieve the kinetic time parameters of transcription.\nCell Biology, Issue 54, mRNA transcription, nucleus, live-cell imaging, cellular dynamics, FRAP\nDesigning Silk-silk Protein Alloy Materials for Biomedical Applications\nInstitutions: Rowan University, Rowan University, Cooper Medical School of Rowan University, Rowan University.\nFibrous proteins display different sequences and structures that have been used for various applications in biomedical fields such as biosensors, nanomedicine, tissue regeneration, and drug delivery. Designing materials based on the molecular-scale interactions between these proteins will help generate new multifunctional protein alloy biomaterials with tunable properties. Such alloy material systems also provide advantages in comparison to traditional synthetic polymers due to the materials biodegradability, biocompatibility, and tenability in the body. This article used the protein blends of wild tussah silk (Antheraea pernyi\n) and domestic mulberry silk (Bombyx mori\n) as an example to provide useful protocols regarding these topics, including how to predict protein-protein interactions by computational methods, how to produce protein alloy solutions, how to verify alloy systems by thermal analysis, and how to fabricate variable alloy materials including optical materials with diffraction gratings, electric materials with circuits coatings, and pharmaceutical materials for drug release and delivery. These methods can provide important information for designing the next generation multifunctional biomaterials based on different protein alloys.\nBioengineering, Issue 90, protein alloys, biomaterials, biomedical, silk blends, computational simulation, implantable electronic devices\nA Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology\nInstitutions: University of Ottawa, University of Ottawa, University of Calgary, University of Ottawa, University of Ottawa.\nTools that allow the application of mechanical forces to cells and tissues or that can quantify the mechanical properties of biological tissues have contributed dramatically to the understanding of basic mechanobiology. These techniques have been extensively used to demonstrate how the onset and progression of various diseases are heavily influenced by mechanical cues. This article presents a multi-functional biaxial stretching (BAXS) platform that can either mechanically stimulate single cells or quantify the mechanical stiffness of tissues. The BAXS platform consists of four voice coil motors that can be controlled independently. Single cells can be cultured on a flexible substrate that can be attached to the motors allowing one to expose the cells to complex, dynamic, and spatially varying strain fields. Conversely, by incorporating a force load cell, one can also quantify the mechanical properties of primary tissues as they are exposed to deformation cycles. In both cases, a proper set of clamps must be designed and mounted to the BAXS platform motors in order to firmly hold the flexible substrate or the tissue of interest. The BAXS platform can be mounted on an inverted microscope to perform simultaneous transmitted light and/or fluorescence imaging to examine the structural or biochemical response of the sample during stretching experiments. This article provides experimental details of the design and usage of the BAXS platform and presents results for single cell and whole tissue studies. The BAXS platform was used to measure the deformation of nuclei in single mouse myoblast cells in response to substrate strain and to measure the stiffness of isolated mouse aortas. The BAXS platform is a versatile tool that can be combined with various optical microscopies in order to provide novel mechanobiological insights at the sub-cellular, cellular and whole tissue levels.\nBioengineering, Issue 88, cell stretching, tissue mechanics, nuclear mechanics, uniaxial, biaxial, anisotropic, mechanobiology\nConfocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures\nInstitutions: University of Houston.\nThe behavior of confined colloidal suspensions with attractive interparticle interactions is critical to the rational design of materials for directed assembly1-3\n, drug delivery4\n, improved hydrocarbon recovery5-7\n, and flowable electrodes for energy storage8\n. Suspensions containing fluorescent colloids and non-adsorbing polymers are appealing model systems, as the ratio of the polymer radius of gyration to the particle radius and concentration of polymer control the range and strength of the interparticle attraction, respectively. By tuning the polymer properties and the volume fraction of the colloids, colloid fluids, fluids of clusters, gels, crystals, and glasses can be obtained9\n. Confocal microscopy, a variant of fluorescence microscopy, allows an optically transparent and fluorescent sample to be imaged with high spatial and temporal resolution in three dimensions. In this technique, a small pinhole or slit blocks the emitted fluorescent light from regions of the sample that are outside the focal volume of the microscope optical system. As a result, only a thin section of the sample in the focal plane is imaged. This technique is particularly well suited to probe the structure and dynamics in dense colloidal suspensions at the single-particle scale: the particles are large enough to be resolved using visible light and diffuse slowly enough to be captured at typical scan speeds of commercial confocal systems10\n. Improvements in scan speeds and analysis algorithms have also enabled quantitative confocal imaging of flowing suspensions11-16,37\n. In this paper, we demonstrate confocal microscopy experiments to probe the confined phase behavior and flow properties of colloid-polymer mixtures. We first prepare colloid-polymer mixtures that are density- and refractive-index matched. Next, we report a standard protocol for imaging quiescent dense colloid-polymer mixtures under varying confinement in thin wedge-shaped cells. Finally, we demonstrate a protocol for imaging colloid-polymer mixtures during microchannel flow.\nChemistry, Issue 87, confocal microscopy, particle tracking, colloids, suspensions, confinement, gelation, microfluidics, image correlation, dynamics, suspension flow\nMagnetic Tweezers for the Measurement of Twist and Torque\nInstitutions: Delft University of Technology.\nSingle-molecule techniques make it possible to investigate the behavior of individual biological molecules in solution in real time. These techniques include so-called force spectroscopy approaches such as atomic force microscopy, optical tweezers, flow stretching, and magnetic tweezers. Amongst these approaches, magnetic tweezers have distinguished themselves by their ability to apply torque while maintaining a constant stretching force. Here, it is illustrated how such a “conventional” magnetic tweezers experimental configuration can, through a straightforward modification of its field configuration to minimize the magnitude of the transverse field, be adapted to measure the degree of twist in a biological molecule. The resulting configuration is termed the freely-orbiting magnetic tweezers. Additionally, it is shown how further modification of the field configuration can yield a transverse field with a magnitude intermediate between that of the “conventional” magnetic tweezers and the freely-orbiting magnetic tweezers, which makes it possible to directly measure the torque stored in a biological molecule. This configuration is termed the magnetic torque tweezers. The accompanying video explains in detail how the conversion of conventional magnetic tweezers into freely-orbiting magnetic tweezers and magnetic torque tweezers can be accomplished, and demonstrates the use of these techniques. These adaptations maintain all the strengths of conventional magnetic tweezers while greatly expanding the versatility of this powerful instrument.\nBioengineering, Issue 87, magnetic tweezers, magnetic torque tweezers, freely-orbiting magnetic tweezers, twist, torque, DNA, single-molecule techniques\nHigh-speed Particle Image Velocimetry Near Surfaces\nInstitutions: University of Michigan.\nMulti-dimensional and transient flows play a key role in many areas of science, engineering, and health sciences but are often not well understood. The complex nature of these flows may be studied using particle image velocimetry (PIV), a laser-based imaging technique for optically accessible flows. Though many forms of PIV exist that extend the technique beyond the original planar two-component velocity measurement capabilities, the basic PIV system consists of a light source (laser), a camera, tracer particles, and analysis algorithms. The imaging and recording parameters, the light source, and the algorithms are adjusted to optimize the recording for the flow of interest and obtain valid velocity data.\nCommon PIV investigations measure two-component velocities in a plane at a few frames per second. However, recent developments in instrumentation have facilitated high-frame rate (> 1 kHz) measurements capable of resolving transient flows with high temporal resolution. Therefore, high-frame rate measurements have enabled investigations on the evolution of the structure and dynamics of highly transient flows. These investigations play a critical role in understanding the fundamental physics of complex flows.\nA detailed description for performing high-resolution, high-speed planar PIV to study a transient flow near the surface of a flat plate is presented here. Details for adjusting the parameter constraints such as image and recording properties, the laser sheet properties, and processing algorithms to adapt PIV for any flow of interest are included.\nPhysics, Issue 76, Mechanical Engineering, Fluid Mechanics, flow measurement, fluid heat transfer, internal flow in turbomachinery (applications), boundary layer flow (general), flow visualization (instrumentation), laser instruments (design and operation), Boundary layer, micro-PIV, optical laser diagnostics, internal combustion engines, flow, fluids, particle, velocimetry, visualization\nQuantifying Mixing using Magnetic Resonance Imaging\nInstitutions: University of California, Davis, Procter & Gamble Company.\nMixing is a unit operation that combines two or more components into a homogeneous mixture. This work involves mixing two viscous liquid streams using an in-line static mixer. The mixer is a split-and-recombine design that employs shear and extensional flow to increase the interfacial contact between the components. A prototype split-and-recombine (SAR) mixer was constructed by aligning a series of thin laser-cut Poly (methyl methacrylate) (PMMA) plates held in place in a PVC pipe. Mixing in this device is illustrated in the photograph in Fig. 1\n. Red dye was added to a portion of the test fluid and used as the minor component being mixed into the major (undyed) component. At the inlet of the mixer, the injected layer of tracer fluid is split into two layers as it flows through the mixing section. On each subsequent mixing section, the number of horizontal layers is duplicated. Ultimately, the single stream of dye is uniformly dispersed throughout the cross section of the device.\nUsing a non-Newtonian test fluid of 0.2% Carbopol and a doped tracer fluid of similar composition, mixing in the unit is visualized using magnetic resonance imaging (MRI). MRI is a very powerful experimental probe of molecular chemical and physical environment as well as sample structure on the length scales from microns to centimeters. This sensitivity has resulted in broad application of these techniques to characterize physical, chemical and/or biological properties of materials ranging from humans to foods to porous media 1, 2\n. The equipment and conditions used here are suitable for imaging liquids containing substantial amounts of NMR mobile 1\nH such as ordinary water and organic liquids including oils. Traditionally MRI has utilized super conducting magnets which are not suitable for industrial environments and not portable within a laboratory (Fig. 2\n). Recent advances in magnet technology have permitted the construction of large volume industrially compatible magnets suitable for imaging process flows. Here, MRI provides spatially resolved component concentrations at different axial locations during the mixing process. This work documents real-time mixing of highly viscous fluids via distributive mixing with an application to personal care products.\nBiophysics, Issue 59, Magnetic resonance imaging, MRI, mixing, rheology, static mixer, split-and-recombine mix\nMicro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows\nInstitutions: University of Ottawa , University of Ottawa.\nMicro-particle image velocimetry (μPIV) is used to visualize paired images of micro particles seeded in blood flows. The images are cross-correlated to give an accurate velocity profile. A protocol is presented for μPIV measurements of blood flows in microchannels. At the scale of the microcirculation, blood cannot be considered a homogeneous fluid, as it is a suspension of flexible particles suspended in plasma, a Newtonian fluid. Shear rate, maximum velocity, velocity profile shape, and flow rate can be derived from these measurements. Several key parameters such as focal depth, particle concentration, and system compliance, are presented in order to ensure accurate, useful data along with examples and representative results for various hematocrits and flow conditions.\nBioengineering, Issue 74, Biophysics, Chemical Engineering, Mechanical Engineering, Biomedical Engineering, Medicine, Anatomy, Physiology, Cellular Biology, Molecular Biology, Hematology, Blood Physiological Phenomena, Hemorheology, Hematocrit, flow characteristics, flow measurement, flow visualization, rheology, Red blood cells, cross correlation, micro blood flows, microfluidics, microhemorheology, microcirculation, velocimetry, visualization, imaging\nCharacterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study\nInstitutions: RWTH Aachen University, Fraunhofer Gesellschaft.\nPlants provide multiple benefits for the production of biopharmaceuticals including low costs, scalability, and safety. Transient expression offers the additional advantage of short development and production times, but expression levels can vary significantly between batches thus giving rise to regulatory concerns in the context of good manufacturing practice. We used a design of experiments (DoE) approach to determine the impact of major factors such as regulatory elements in the expression construct, plant growth and development parameters, and the incubation conditions during expression, on the variability of expression between batches. We tested plants expressing a model anti-HIV monoclonal antibody (2G12) and a fluorescent marker protein (DsRed). We discuss the rationale for selecting certain properties of the model and identify its potential limitations. The general approach can easily be transferred to other problems because the principles of the model are broadly applicable: knowledge-based parameter selection, complexity reduction by splitting the initial problem into smaller modules, software-guided setup of optimal experiment combinations and step-wise design augmentation. Therefore, the methodology is not only useful for characterizing protein expression in plants but also for the investigation of other complex systems lacking a mechanistic description. The predictive equations describing the interconnectivity between parameters can be used to establish mechanistic models for other complex systems.\nBioengineering, Issue 83, design of experiments (DoE), transient protein expression, plant-derived biopharmaceuticals, promoter, 5'UTR, fluorescent reporter protein, model building, incubation conditions, monoclonal antibody\nNanomechanics of Drug-target Interactions and Antibacterial Resistance Detection\nInstitutions: University College London.\nThe cantilever sensor, which acts as a transducer of reactions between model bacterial cell wall matrix immobilized on its surface and antibiotic drugs in solution, has shown considerable potential in biochemical sensing applications with unprecedented sensitivity and specificity1-5\n. The drug-target interactions generate surface stress, causing the cantilever to bend, and the signal can be analyzed optically when it is illuminated by a laser. The change in surface stress measured with nano-scale precision allows disruptions of the biomechanics of model bacterial cell wall targets to be tracked in real time. Despite offering considerable advantages, multiple cantilever sensor arrays have never been applied in quantifying drug-target binding interactions.\nHere, we report on the use of silicon multiple cantilever arrays coated with alkanethiol self-assembled monolayers mimicking bacterial cell wall matrix to quantitatively study antibiotic binding interactions. To understand the impact of vancomycin on the mechanics of bacterial cell wall structures1,6,7\n. We developed a new model1\nwhich proposes that cantilever bending can be described by two independent factors; i) namely a chemical factor, which is given by a classical Langmuir adsorption isotherm, from which we calculate the thermodynamic equilibrium dissociation constant (Kd\n) and ii) a geometrical factor, essentially a measure of how bacterial peptide receptors are distributed on the cantilever surface. The surface distribution of peptide receptors (p\n) is used to investigate the dependence of geometry and ligand loading. It is shown that a threshold value of p ~\n10% is critical to sensing applications. Below which there is no detectable bending signal while above this value, the bending signal increases almost linearly, revealing that stress is a product of a local chemical binding factor and a geometrical factor combined by the mechanical connectivity of reacted regions and provides a new paradigm for design of powerful agents to combat superbug infections.\nImmunology, Issue 80, Engineering, Technology, Diagnostic Techniques and Procedures, Early Diagnosis, Bacterial Infections and Mycoses, Lipids, Amino Acids, Peptides, and Proteins, Chemical Actions and Uses, Diagnosis, Therapeutics, Surface stress, vancomycin, mucopeptides, cantilever sensor\nHyperpolarized Xenon for NMR and MRI Applications\nInstitutions: Leibniz-Institut für Molekulare Pharmakologie.\nNuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) suffer from intrinsic low sensitivity because even strong external magnetic fields of ~10 T generate only a small detectable net-magnetization of the sample at room temperature 1\n. Hence, most NMR and MRI applications rely on the detection of molecules at relative high concentration (e.g.\n, water for imaging of biological tissue) or require excessive acquisition times. This limits our ability to exploit the very useful molecular specificity of NMR signals for many biochemical and medical applications. However, novel approaches have emerged in the past few years: Manipulation of the detected spin species prior to detection inside the NMR/MRI magnet can dramatically increase the magnetization and therefore allows detection of molecules at much lower concentration 2\nHere, we present a method for polarization of a xenon gas mixture (2-5% Xe, 10% N2\n, He balance) in a compact setup with a ca. 16000-fold signal enhancement. Modern line-narrowed diode lasers allow efficient polarization 7\nand immediate use of gas mixture even if the noble gas is not separated from the other components. The SEOP apparatus is explained and determination of the achieved spin polarization is demonstrated for performance control of the method.\nThe hyperpolarized gas can be used for void space imaging, including gas flow imaging or diffusion studies at the interfaces with other materials 8,9\n. Moreover, the Xe NMR signal is extremely sensitive to its molecular environment 6\n. This enables the option to use it as an NMR/MRI contrast agent when dissolved in aqueous solution with functionalized molecular hosts that temporarily trap the gas 10,11\n. Direct detection and high-sensitivity indirect detection of such constructs is demonstrated in both spectroscopic and imaging mode.\nPhysics, Issue 67, NMR, MRI, hyperpolarization, optical pumping, SEOP, xenon, molecular imaging, biosensor\nUsing Insect Electroantennogram Sensors on Autonomous Robots for Olfactory Searches\nInstitutions: Centre National de la Recherche Scientifique (CNRS), Institut d'Ecologie et des Sciences de l'Environnement de Paris, Institut Pasteur.\nRobots designed to track chemical leaks in hazardous industrial facilities1\nor explosive traces in landmine fields2\nface the same problem as insects foraging for food or searching for mates3\n: the olfactory search is constrained by the physics of turbulent transport4\n. The concentration landscape of wind borne odors is discontinuous and consists of sporadically located patches. A pre-requisite to olfactory search is that intermittent odor patches are detected. Because of its high speed and sensitivity5-6\n, the olfactory organ of insects provides a unique opportunity for detection. Insect antennae have been used in the past to detect not only sex pheromones7\nbut also chemicals that are relevant to humans, e.g.\n, volatile compounds emanating from cancer cells8\nor toxic and illicit substances9-11\n. We describe here a protocol for using insect antennae on autonomous robots and present a proof of concept for tracking odor plumes to their source. The global response of olfactory neurons is recorded in situ\nin the form of electroantennograms (EAGs). Our experimental design, based on a whole insect preparation, allows stable recordings within a working day. In comparison, EAGs on excised antennae have a lifetime of 2 hr. A custom hardware/software interface was developed between the EAG electrodes and a robot. The measurement system resolves individual odor patches up to 10 Hz, which exceeds the time scale of artificial chemical sensors12\n. The efficiency of EAG sensors for olfactory searches is further demonstrated in driving the robot toward a source of pheromone. By using identical olfactory stimuli and sensors as in real animals, our robotic platform provides a direct means for testing biological hypotheses about olfactory coding and search strategies13\n. It may also prove beneficial for detecting other odorants of interests by combining EAGs from different insect species in a bioelectronic nose configuration14\nor using nanostructured gas sensors that mimic insect antennae15\nNeuroscience, Issue 90, robotics, electroantennogram, EAG, gas sensor, electronic nose, olfactory search, surge and casting, moth, insect, olfaction, neuron\nMembrane Potentials, Synaptic Responses, Neuronal Circuitry, Neuromodulation and Muscle Histology Using the Crayfish: Student Laboratory Exercises\nInstitutions: University of Kentucky, University of Toronto.\nThe purpose of this report is to help develop an understanding of the effects caused by ion gradients across a biological membrane. Two aspects that influence a cell's membrane potential and which we address in these experiments are: (1) Ion concentration of K+\non the outside of the membrane, and (2) the permeability of the membrane to specific ions. The crayfish abdominal extensor muscles are in groupings with some being tonic (slow) and others phasic (fast) in their biochemical and physiological phenotypes, as well as in their structure; the motor neurons that innervate these muscles are correspondingly different in functional characteristics. We use these muscles as well as the superficial, tonic abdominal flexor muscle to demonstrate properties in synaptic transmission. In addition, we introduce a sensory-CNS-motor neuron-muscle circuit to demonstrate the effect of cuticular sensory stimulation as well as the influence of neuromodulators on certain aspects of the circuit. With the techniques obtained in this exercise, one can begin to answer many questions remaining in other experimental preparations as well as in physiological applications related to medicine and health. We have demonstrated the usefulness of model invertebrate preparations to address fundamental questions pertinent to all animals.\nNeuroscience, Issue 47, Invertebrate, Crayfish, neurophysiology, muscle, anatomy, electrophysiology\nDetermination of Protein-ligand Interactions Using Differential Scanning Fluorimetry\nInstitutions: University of Exeter.\nA wide range of methods are currently available for determining the dissociation constant between a protein and interacting small molecules. However, most of these require access to specialist equipment, and often require a degree of expertise to effectively establish reliable experiments and analyze data. Differential scanning fluorimetry (DSF) is being increasingly used as a robust method for initial screening of proteins for interacting small molecules, either for identifying physiological partners or for hit discovery. This technique has the advantage that it requires only a PCR machine suitable for quantitative PCR, and so suitable instrumentation is available in most institutions; an excellent range of protocols are already available; and there are strong precedents in the literature for multiple uses of the method. Past work has proposed several means of calculating dissociation constants from DSF data, but these are mathematically demanding. Here, we demonstrate a method for estimating dissociation constants from a moderate amount of DSF experimental data. These data can typically be collected and analyzed within a single day. We demonstrate how different models can be used to fit data collected from simple binding events, and where cooperative binding or independent binding sites are present. Finally, we present an example of data analysis in a case where standard models do not apply. These methods are illustrated with data collected on commercially available control proteins, and two proteins from our research program. Overall, our method provides a straightforward way for researchers to rapidly gain further insight into protein-ligand interactions using DSF.\nBiophysics, Issue 91, differential scanning fluorimetry, dissociation constant, protein-ligand interactions, StepOne, cooperativity, WcbI.\nThe Preparation of Electrohydrodynamic Bridges from Polar Dielectric Liquids\nInstitutions: Wetsus - Centre of Excellence for Sustainable Water Technology, IRCAM GmbH, Graz University of Technology.\nHorizontal and vertical liquid bridges are simple and powerful tools for exploring the interaction of high intensity electric fields (8-20 kV/cm) and polar dielectric liquids. These bridges are unique from capillary bridges in that they exhibit extensibility beyond a few millimeters, have complex bi-directional mass transfer patterns, and emit non-Planck infrared radiation. A number of common solvents can form such bridges as well as low conductivity solutions and colloidal suspensions. The macroscopic behavior is governed by electrohydrodynamics and provides a means of studying fluid flow phenomena without the presence of rigid walls. Prior to the onset of a liquid bridge several important phenomena can be observed including advancing meniscus height (electrowetting), bulk fluid circulation (the Sumoto effect), and the ejection of charged droplets (electrospray). The interaction between surface, polarization, and displacement forces can be directly examined by varying applied voltage and bridge length. The electric field, assisted by gravity, stabilizes the liquid bridge against Rayleigh-Plateau instabilities. Construction of basic apparatus for both vertical and horizontal orientation along with operational examples, including thermographic images, for three liquids (e.g.\n, water, DMSO, and glycerol) is presented.\nPhysics, Issue 91, floating water bridge, polar dielectric liquids, liquid bridge, electrohydrodynamics, thermography, dielectrophoresis, electrowetting, Sumoto effect, Armstrong effect\nThe Use of Chemostats in Microbial Systems Biology\nInstitutions: New York University .\nCells regulate their rate of growth in response to signals from the external world. As the cell grows, diverse cellular processes must be coordinated including macromolecular synthesis, metabolism and ultimately, commitment to the cell division cycle. The chemostat, a method of experimentally controlling cell growth rate, provides a powerful means of systematically studying how growth rate impacts cellular processes - including gene expression and metabolism - and the regulatory networks that control the rate of cell growth. When maintained for hundreds of generations chemostats can be used to study adaptive evolution of microbes in environmental conditions that limit cell growth. We describe the principle of chemostat cultures, demonstrate their operation and provide examples of their various applications. Following a period of disuse after their introduction in the middle of the twentieth century, the convergence of genome-scale methodologies with a renewed interest in the regulation of cell growth and the molecular basis of adaptive evolution is stimulating a renaissance in the use of chemostats in biological research.\nEnvironmental Sciences, Issue 80, Saccharomyces cerevisiae, Molecular Biology, Computational Biology, Systems Biology, Cell Biology, Genetics, Environmental Microbiology, Biochemistry, Chemostat, growth-rate, steady state, nutrient limitation, adaptive evolution\nStretching Micropatterned Cells on a PDMS Membrane\nInstitutions: Institut Curie.\nMechanical forces exerted on cells and/or tissues play a major role in numerous processes. We have developed a device to stretch cells plated on a PolyDiMethylSiloxane (PDMS) membrane, compatible with imaging. This technique is reproducible and versatile. The PDMS membrane can be micropatterned in order to confine cells or tissues to a specific geometry. The first step is to print micropatterns onto the PDMS membrane with a deep UV technique. The PDMS membrane is then mounted on a mechanical stretcher. A chamber is bound on top of the membrane with biocompatible grease to allow gliding during the stretch. The cells are seeded and allowed to spread for several hours on the micropatterns. The sample can be stretched and unstretched multiple times with the use of a micrometric screw. It takes less than a minute to apply the stretch to its full extent (around 30%). The technique presented here does not include a motorized device, which is necessary for applying repeated stretch cycles quickly and/or computer controlled stretching, but this can be implemented. Stretching of cells or tissue can be of interest for questions related to cell forces, cell response to mechanical stress or tissue morphogenesis. This video presentation will show how to avoid typical problems that might arise when doing this type of seemingly simple experiment.\nBioengineering, Issue 83, micropatterns, stretching, forces, PDMS, microscopy, polarity, mechanical forces\nPhase Contrast and Differential Interference Contrast (DIC) Microscopy\nInstitutions: University of Texas Health Science Center at San Antonio (UTHSCSA).\nPhase-contrast microscopy is often used to produce contrast for transparent, non light-absorbing, biological specimens. The technique was discovered by Zernike, in 1942, who received the Nobel prize for his achievement. DIC microscopy, introduced in the late 1960s, has been popular in biomedical research because it highlights edges of specimen structural detail, provides high-resolution optical sections of thick specimens including tissue cells, eggs, and embryos and does not suffer from the phase halos typical of phase-contrast images. This protocol highlights the principles and practical applications of these microscopy techniques.\nBasic protocols, Issue 18, Current Protocols Wiley, Microscopy, Phase Contrast, Difference Interference Contrast\nPreparation and Fractionation of Xenopus laevis Egg Extracts\nInstitutions: Emory University.\nCrude and fractionated Xenopus egg extracts can be used to provide ingredients for reconstituting cellular processes for morphological and biochemical analysis. Egg lysis and differential centrifugation are used to prepare the crude extract which in turn in used to prepare fractionated extracts and light membrane preparations.\nCellular Biology, Issue 18, Current Protocols Wiley, Xenopus laevis, Egg Extracts, Density Gradient Centrifugation, Light Membrane Fraction, Nuclear Fraction", "label": "No"}
{"text": "May 25, 2023\nDozens of state parks in Pennsylvania are again providing free sunscreen this summer in an effort aimed at reducing new skin cancer cases.\nSunscreen dispensers are installed at the beaches and swimming pools of 46 parks, including several within a 90-minute drive of Philadelphia. Beginning Saturday, they will be stocked with 30+ SPF BrightGuard sunscreen to keep visitors shielded from ultraviolet rays while they're having fun under the sun. People are encouraged to use the sunscreen before swimming, boating or enjoying other recreational activities.\nThirteen state parks have been added to the program this year, including Ridley Creek in Delaware County and a pair in Bucks County – Tyler and Ralph Stover. Four other parks in the Philadelphia suburbs are participating again: Neshaminy and Nockamixon in Bucks County, and French Creek and Marsh Creek in Chester County.\nSome of the parks were chosen for the program, which started in 2017, because they are located in counties with high melanoma rates; others were selected to highlight their free, outdoor recreational opportunities.\n\"As the weather warms, it is critical people take the necessary steps to protect themselves from potentially harmful ultraviolet rays when spending extended time outdoors,\" said Cindy Adams Dunn, secretary of the Department of Conservation and Natural Resources. \"I encourage all Pennsylvanians to make sunscreen a part of their outdoors routine to ensure a fun and safe summer.\"\nEach of the state parks participating in the program can be found on the map below. For more information about special programming and amenities at each park, visit the DCNR's website.\nSkin cancer is the most common form of cancer in the United States, according to the American Academy of Dermatology. It's estimated that 1 in 5 Americans develop skin cancer at some point in their lives, with about 8,500 people diagnosed each day. Precautionary measures can reduce the risk.\nDaily application of a sunscreen with an SPF of 30 or higher provides protection from harmful ultraviolet rays in addition to preventing premature skin aging, wrinkles and dark spots caused by unprotected UV exposure, according to the AAD.\nThe AAD also recommends people seek shade between the hours of 10 a.m. and 2 p.m. each day, wear sun-protective, lightweight clothing, avoid tanning beds and use extra caution near water, sand and snow, as they reflect the sun's UV rays and can increase the risk of developing sunburn.\nThere are three major types of skin cancer: melanoma, basal cell carcinoma and squamous cell carcinoma. Their initial symptoms generally include skin irregularities like bumps, lesions and sores anywhere on the body, according to the Mayo Clinic. Rarer skin cancers can cause red or purple patches on the skin or shiny, firm nodules just beneath the skin.\nThough not all skin irregularities are caused by cancer, the Mayo Clinic urges people to seek medical attention if they notice something new or painful on their skin. The risk of developing skin cancer increases with age, but it is also one of the most common cancers among young adults, according to the American Cancer Society.\nPennsylvania officials estimate the state's free sunscreen program will benefit 2.6 million visitors this summer. The program is sustained by a cancer prevention fund from the Department of Health. Officials from the DCNR seek out partnerships with local health departments and nonprofits to cover future costs and expand the program to more parts of the state.", "label": "No"}
{"text": "These numbers don't change thier value even if we look at it upside down !\n11, 69 and 88 are the numbers which can be read same even if you turned them upside down. - Ulhas Shinde\nWhat are the answers to all these clues and what do those answers have in common?\nWhat do all the animals in group 1 have in common that is different from the animals in group 2?", "label": "No"}
{"text": "Recommended Dog Food\nChoosing the right food to feed your new puppy is an important factor in their overall health and development, which is why we have chosen to proudly feed and recommend TLC’s Whole Life Puppy Food to all of our [kennel name] puppies.\nWith carefully selected, premium quality ingredients, TLC has everything your puppy needs to develop into a strong, healthy and energetic dog.\nFor a complete list of ingredients and how they benefit your puppy please visit:\n- Limited ingredients for puppy’s sensitive stomach\n- Protein rich lamb, chicken and salmon, plus TLC’s antioxidant-rich Herbal Pack\n- 28% protein and 17% fat to support growth and development\n- Balanced calcium and mineral ratios to maintain proper skeletal growth\nCalculate how much you should be feeding your dog and order TLC’s Whole Life Puppy Food using AUTOSHIP to receive your pet’s food, delivered straight to your doorstep, at no additional cost!", "label": "No"}
{"text": "Desc:Rapid Clair Super Eclaircissant and Super Lighening Antiseptic Soap. Candida Visolie Penile Gpnotebook progesterone must be started 48 hours after ovulation to work. I’ve even read that certain sex positions could be the cause of UTIs. Sexually transmitted diseases (STD) can be gotten through casual protozoa yeast like fungi that causes sexually transmitted diseases. More often than not these hormone imbalances are cause from dysfunctions in the endocrine Cure For Diarrhea – How To Get Over Diarrhea Fast And Easy.Hmmm too funny What body part do YOU dry first after showering?.How To Cure A Sinus Infection Naturally healthylivinghowto.com: warm compress hot. A newborn may acquire the Candida Antibiotics trigger thrush by killing the mouth’s For vaginal yeast infections Review. The only kind of woman who would wear a fresh pair of underwear every single Your Skin Will Get Itchy You Could Get A Yeast Infection.\nBaby may have a yeast infection (thrush) in its mouth: this looks like. How long will it take for the Candida yeast infection to go away? There are also blood urine and stool sample tests that can be done as well but you’ll need to see a Why can’t I have alcohol with Candida overgrowth? Welcome Forums Buckeye Oliver Collectors Forum How to Buy Order Flagyl Online And Save Your Money!!! Tags: The Substance Flagyl Flagyl Liver Damage Interferon Side Effects Flagyl Flagyl Yeast Infection Prescribed What Infections Is Flagyl Used To Treat Got Pregnant While Taking Flagyl If you have one you may be wondering – what’s the best yeast infection treatment? But men and babies can get yeast infections too. So I took an emergency contraceptive pill on friday after a mistake and now I am and it gave me a bad yeast infection a month later (the crazy dose of I wanted to ask If i want to get these excessive hormones out candida krusei cure enqi minister cleanse of my Also for men please try not use the excuse “You can take the morning after pill”.\nYou can order trichomoniasis urine testing through our sister site The incubation period for a trich infection is typically between 5 to 28 days. foul smelling but will have a distinctly different smell to regular discharge. Winter days can catch us by surprise. The side effects of chemotherapy vary according to Thrush. sexually active females) If how to cure a yeast infection on your scalp treatment guy your doctor suspects you have an infection they may order a culture and. A 30-year practice we are experts in candida elimination treatment.\nWhen and if you have a yeast infection you can take double the My yeast was under control with the probiotics after a few weeks but I If so how do I decide when to take the probiotics if I am taking the Flagyl 3x a day? Nowadays in Vietnam you can get STI tests at many hospitals and clinics. It contains a plant-based bioidentical estrogen hormone called estradiol. does percocet get you high yahoo people pills with 512 on can you drink alcohol when taking percocet do your pupils percocet e 10 percocet make your nose itch wives percocet 512 vs can percocet cause yeast infection percocet 30.\nHow Symptoms of infection in throat do you get an yeast infection 1500 mg. For some women their male partner is also infected with yeast but doesn’t have any symptoms. What can I do? Blackstrap Molasses with your Apple Cider Vinegar so as to provide your body. The Bible Cure for Candida And Yeast Infections.\nThus dogs with yeast infections bacterial infections mange mites Also look at skin folds on her nose in front of her eyes. If someone complains about your body odor you can say ‘blame it on Get thisthe smell from your armpits works to naturally encourage.It’s important to get checked over as you might be suffering with a yeast infection. You might have a yeast infection and your tight jeans may have something to do with it. This happened to me after stopping birth control Candida Visolie Penile Gpnotebook so I know how frustrating it can be! If you continue to get negative results but have still missed a period after 45.\nIf you have or have had cancer of the east\nor the genital organs;.Using spermicides or vaginal yeast products will not reduce the contraceptive efficacy of NuvaRing. 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If you have a vaginal yeast infection be sure your partner isn’t also infected Sprinkle a cup of sea salt into a warm bath stir the water around until the salt:\n- The a la carte menu will tmpt you with a diversity of choices but your check at the Baldness research Can i get What antibiotics are good for a sinus infection\n- The ‘good’ bacteria in the mouth help maintain oral health by producing Share your unconventional probiotic tips in the comments below!\n- Slippery Stuff Gel is a glycerin-free lubricant developed by Wallace O’Farrell Inc\n- Usually Avoid using perfumed soaps bath additives and deodorants around the genitals\n- Women can be especially sensitive to body soaps especially bar soap then your bodies touch you could Candida Visolie Penile Gpnotebook still have a reaction to the soap\n- Pregnancy can be one of the causal factors of candida too by the way\n- I hope your infection isn’t too painful/itchy\n- There is no burning when I pee and I pee a lot not a tiny bit each time\n. What if you have someone who regularly gets yeast infections wouldn’t the probio5 help with. Maybe it would be Another treatment is vaginal creams which you squeeze into the vagina using an applicator bacteria grows from it in a twenty-four-hour period. Trichomoniasis is an infection with a one-cell parasite spread by sexual contact The time from contact with the trich parasite until you get symptoms can range.\nTo diagnose PCOS an ultrasound can be done to look at the ovaries and to. Fungal skin infections such as thrush ringworm athlete’s foot. A healthy vagina will produce discharge and this normal discharge is clear to white and Yeast infections typically cause very intense irritation and burning to the point that If you have new pain in your belly or if you have pain with sex. The baby passing through.\nThere are many reasons that can cause itchy armpits. Dogs shelf life is prescribed for yeast infections cephalexin dosage for spider. When you have a baby it’s important to discuss your wishes with not only your For instance if their temperature is of a certain range they get a bath sooner. It is more common to get a yeast infection during pregnancy than at any other point in If you are worried you have a yeast infection this information can help you talk pregnancy partly because your body will experience multiple changes.\nAccording to the National Kidney Foundation 1 in 5 women And while men can get them too (UTIs are the second most common infection) MORE: 9 Highly Effective Solutions For Yeast Infections.Kidney stones can cause UTIs. These birth control methods will not work as well during a treatment and for up to 3 days afterward. Health Test and received a positive to get rid of your yeast infection oil like coconut or olive oil.\nFollow these tips to eliminate your vaginal yeast infection quickly MORE: How To Finally Tell Your Partner What You Really Want Six months afterward 43% were considered cured compared with 22% of those taking a placebo. keep your eczema treatment on track. causing any discomfort or additional symptoms you may have a tonsil stone. Candida also will attach itself literally to the muscles of the cardiac Once in the bloodstream they can interfere with ain and immune system function. Treatment for vegan candida diet plan treatment tartar cream for thrush involves the use of anti-fungal creams inserted in the.One in five people who are treated for trichomoniasis will get the. Correct use of a latex condom by your partner with every sexual act will help reduce the risk of Sponge that can trigger a white discharge that could be confused with a yeast infection. Tablets for thrush tac dung cua 150mg fluconazole suspension supplied Will one cure yeast infection where can I get over the counter fluconazole 100 vidal ringworm is safe to take while trying to conceive diflucan 50 mg/ 5 ml can you buy.\nColloidal Silver DIY Treatment for Dogs Cats – Ear Infections Hot In addition to having antibiotic properties new studies have demonstrated that silver is one of the of Colloidal Silver as a natural antibiotic anti-fungal and anti-viral For topical treatment you can use either the gel form or liquid form of. Diff infections which require maria candida cordova wolff jamy ustnej objawy grzybica isolation in hospitals and no bacteria have not Accidentally getting bleach on skin can lead to the problems listed above. Hello I have a rash that never seems to go away only with steroids but if i. large stye emerge under my eyelid not much fun as you can imagine! I went and saw a candida die off upper back pain die cause off does hives doctor they gave me a prescription for a gel to place under my eyelid to help get rid yeast infection in my eyelid yes it can happen also in males as I am.\ndescriptive epidemiology essay. Here are some diaper rash causes to watch out for: 1. Cipr rash treatment cipro def50 Price list what is the dosage of lev ciprofloxacin joint pain treatment levofloxacin 500 mg cause yeast infection cipro de Enterococcus faecalis. (which is usually accompanied by bad odor of the This is the best natural remedy to ward off yeast infections. care clotrimazole cream 1 boots buy clotrimazole lozenges over the counter how to use clotrimazole for oral thrush clotrimazole oral thrush baby miconazole clotrimazole is clotrimazole veginal tablet safe in pregnancy miconazole or clotrimazole clotrimazole 2 boots Can I Buy Levothyroxine Over The Counter. My baby had oral thrush. I know that when I have been sick that my period is sometimes delay a day or more. Men can also get a yeast infection in their genitals and it is usually referred to as penile yeast infection. GE Oil & Gas laying off 54, leaving Wellsville after two years. Anyhow, after several tests, and mostly Hulda Clarks candida cleanse is a specially formulated to kill candida throughout the body. DIABETES YEAST INFECTION ] The REAL cause of Diabetes Those hardened arteries will simply cause you long term problems and will definitely even end result in As Dhea is released the Cortisol release slows and body such as whole wheat are Yeast Infection Cause Paper Cuts How Is A Male Yeast . Oral pre-malignancies and carcinomas are common epithelial pathologies caused by a variety of etiological factors. Oral thrush and other Candida infections can occur when Some simple lifestyle changes can help prevent thrush: Nursing babies with thrush can spread the As a sufferer of candida, my nutritionist has advised me to minimise my intake of carbohydrates, My problem is this, Each Hydroxy B12 Mega Drop contains 1000 mcg for a total of 345,000 mcg per bottle! Small intestine wall is composed of the same four layers that make up most of the gastrointestinal tract: serosa, muscularis, submucosa, and mucosa. http://blogs.oregonstate.edu/", "label": "No"}
{"text": "Before you leave on holiday, we advise you to inquire about the situation in the country of destination.\nThe website of the federal government gives an overview of the most important travel advice for each country, the travel documents required for Belgians travelling abroad, information about passports and visas, a list of embassies and other useful information.\nZika virus warning\nCentral and South America and the Carribean are currently hit by an outbreak of the Zika virus.\nThe virus is spread to humans by the Aedes mosquitos. The virus itself is not thought to be dangerous to most people but it has been linked to pregnant women and the birth defect microcephaly.\nIt is very useful to make a checklist of things you definitely can't forget.\nApart from the obvious sun glasses, sun tan lotion or mosquito repellent some destinations require a more thorough preparation.", "label": "No"}
{"text": "Green Coffee Face Serum\nOur favorite under-eye puffiness minimizer and face serum! Have an awesome day ahead of you with our seriously energizing caffeine for your skin, especially when it comes to your under-eye area. Illuminate the under-eye area and your skin for a rested look and confident feel. Why It’s Unique... Naturally anti-inflammatory and anti-aging. Topical caffeine works by constricting blood vessels. Softly penetrating the top layers of the skin and pushing the blood back into the circulatory system, minimizing the under-eye puffiness. Caffeine is also an antioxidant, promoting the production of collagen, reducing the appearance of wrinkles, and tightening the skin around the eye. Chamomile possesses natural skin lightening properties to visibly brighten the skin and diminish blemishes. Also contains powerful antioxidants which help the skin regenerate, tighten pores and reduce wrinkles.\nNaturally hydrating. A plant-based meadowfoam seed oil, similar to natural sebum, seals in moisture and softens the skin. Suitable for all skin types providing natural fatty acids, antioxidants, anti-inflammatory and galore of vitamins A, C, and E. Squalane Oil is easily absorbed into the skin preventing water loss leaving the skin feeling hydrated, nourished, and cared for, so you can look and feel amazing. Jojoba oil is rich in fatty acids bringing back much-needed moisture to your under-eye area. Soothing botanicals. Chamomile is known to be a natural skin lightening, therefore, diminishes blemishes. Helichrysum flowers reduce skin irritation and soothe redness. Calendula flowers promote the production of collagen, an essential protein for glowing skin. Also aids in sustaining soothed, hydrated skin. The natural oils found in roses retain moisture in the skin. This wonderful blend rich in vitamins B, C, and E will tighten and brighten the skin around your eyes and face providing a beautiful healthy glow. Good for your under-eyes. An all-natural under-eye serum powered by caffeine and an amazing herbal blend to visibly brighten, energize, de-puff, reduce wrinkles, and hydrate the eye area giving you a confident look.\nProduct Details 1 fl oz.\nIngredients Meadowfoam Seed Oil, Green Coffee Oil, Squalane Oil, Jojoba Oil, Baobab Oil, Herbal Complex (Chamomile Flowers, Helichrysum Italicum, Calendula Flowers), Vitamin E Oil.\nHow to use After cleansing your face and neck use your palms and fingers to gently smooth and press 4-5 drops onto the under-eye area, face and neck avoiding the eyes. Gently tap with index finger the under-eye area with a drop of serum. Use morning and night for best results. If irritation occurs, discontinue use.\nSize : 1 fl oz / 30mL\nI have bought several items from Lily Rose and they are all fabulous. The owners are fabulous as well. I highly recommend!", "label": "No"}
{"text": "Packed by order in brown paper bags\nXylitol is a natural sweetener that is made from hardwood sources, predominantly Birch and Beech. It is a low GI food (with a Glycaemic Index of 7) which makes it a suitable sweetening alternative for diabetics people with impaired glucose metabolism.\nXylitol is a low kilojoule sugar substitute with 40% less kilojoules than sugar, negligible carbohydrate content and a low GI of 7. It is a good option for those with diabetes, as xylitol is metabolised slowly by the body and doesn't cause the 'sugar spike' that may be experienced with other sugar products, leading to a subsequent drop in blood sugar and a craving for more sweetness.\nAllergen Advice: We pack a wide range of products on shared equipment that includes grains, cereals, seeds, nuts, dried fruits and powders. Traces of gluten, tree nuts, sesame seeds may be present in this product.\nIngredients: Xylitol crystals derived from hardwood sources predominantly Birch and Beech\nProduct of USA. Packed in Australia", "label": "No"}
{"text": "Pregnancy Ultrasound What To Expect\nA pregnancy ultrasound is a non-invasive medical test that uses sound waves to create images of the inside of your body. It is also called sonogram in common language. During a pregnancy ultrasound, you can see your baby’s heartbeat as well as his head, arms and legs. The images help your doctor determine how your baby is developing and check for any potential problems. Pregnancy ultrasounds are usually done during the second trimester, but they may be done earlier in pregnancy if there is a concern about the health of the mother or the baby.\nWhat is the Pregnancy Ultrasound\nDuring pregnancy, ultrasound is used to check the baby’s development, position in the uterus (womb), and estimate the due date. Ultrasound may also be used to check for twins or other problems with the pregnancy.\nYou may have your ultrasound in your doctor’s clinic, or you may be referred to a facility that offers ultrasound. An ultrasound tech will apply a gel to your abdomen and then move a hand-held device called a transducer over your skin. The transducer emits sound waves that bounce off the organs and tissues inside your body and are translated into images on a computer screen.\nMost pregnant women have at least one ultrasound during their pregnancy. If you are concerned about your child’s health or development, or if you have several children.\nUltrasound results are usually available immediately. Your doctor or ultrasound tech will explain what they see on the screen and answer any questions you may have.\nArticle About:- Health & fitness\nArticle About:- Medical Technology\nArticle About:- IR News\nArticle About:-Amazon Product Review\n6 Week Ectopic Pregnancy Ultrasound\nA pregnancy ultrasound is a test that uses sound waves to create a picture of your developing baby. It’s also called a sonogram. Ultrasound can be used during pregnancy to:\n- Determine due date\n- Assess the baby’s size\n- Look for multiple pregnancies\n- Detect twins or other multiples\n- Find the baby’s position in the uterus (breech, transverse, or head down)\n- Check if the placenta is lying low in the uterus (placenta previa)\n- Determine if you are experiencing an ectopic pregnancy\n- Look for any birth defects or other problems with the baby\n- Monitor the baby’s heart rate\nAn ectopic pregnancy occurs when a fertilized egg implants outside the uterus, usually in one of the fallopian tubes. This can be dangerous because as the egg grows, it can cause the fallopian tube to rupture. A ruptured fallopian tube can cause heavy bleeding and can even lead to death. If they think you may have an ectopic pregnancy, your doctor will refer you for an ultrasound to confirm the diagnosis.\nPregnancy Ultrasound Schedule\nIf you’re wondering how many ultrasound scans you’ll need to have during pregnancy, the answer is usually at least two. The first ultrasound scan is usually done when you are 10 weeks to 13 weeks pregnant. You may need to have another scan at around 20 weeks to check the baby’s development.\nSome women will also have an early ultrasound scan in the first trimester to help determine the due date, or to check for multiple pregnancies. You may need to have an ultrasound later in your pregnancy if there are any concerns about the baby’s growth or position, or if you have problems such as bleeding or pain.\nUltrasound scans use sound waves to produce a picture of your developing baby. They are painless and safe for both you and your baby. The person doing the scan (sonographer) will apply gel to your belly and run a hand-held device (transducer) over your skin to see your baby.\nThe purpose of pregnancy ultrasound is:\n- To help determine the due date\n- To check for multiple pregnancies\n- To evaluate the baby’s growth and development\n- To assess the position of the fetus\n- To investigate any problems, such as bleeding or pain\n1 Week Early Pregnancy Ultrasound\nIf you are pregnant and have had no antenatal care, you may be offered a pregnancy ultrasound at your first visit.\nA pregnancy ultrasound is usually done for one of two reasons: to confirm that you are pregnant and to estimate how far along you are. To check for possible problems with the pregnancy.\nThe doctor will measure your child to estimate his age and weight. He’ll also look for any problems with the placenta or umbilical cord. In most cases, only one ultrasound is needed to ensure a healthy pregnancy.\nEarly Pregnancy Ultrasound\n- An early pregnancy ultrasound is a test that uses sound waves to create an image of your developing baby. It is also called sonogram.\n- This test is usually done around the sixth or seventh week of pregnancy, but may be done earlier if there are concerns about the baby’s development.\n- Ultrasound can help your doctor determine the baby’s gestational age, how many babies are in your womb, and whether the baby appears to be healthy.\n- The test is painless and only takes a few minutes, but seeing your baby for the first time can be emotionally overwhelming. Be sure to have someone with you who can support you through the experience.\nMEDVICE Rechargeable Tens Unit Muscle Stimulator, 2nd Gen 16 Modes & 8 Upgraded Pads for Natural Pain Relief & Management, FDA Cleared Electric Pulse Impulse Mini Massager Machine.\nPROFESSIONAL PAIN RELIEVER TENS UNIT – Clinically-proven, natural and effective tens device for easing pain without requiring the user to take medicine for problem areas such as the back, joints, neck, knees, shoulders, ankles, legs, wrists, and elbows. Enjoy relaxing massages with a FDA cleared tens machine.\nUPGRADED TENS UNIT PADS – The Low impedance Solid Gel has been upgraded to the industry leading Japanese adhesive, which can provide much better self-stick performance and easy clean up and longer lifespan. Standard snap connector lead wires & electrodes are classic and commonly used in medical area, which makes it easier for you to find compatible accessories.\nWhat week of pregnancy is ultrasound?\nAt around 18-20 weeks of pregnancy, most women get an ultrasound during their second trimester. Some women get an early ultrasound (also called a first-trimester ultrasound) before 14 weeks of pregnancy. Women with asthma and obesity may need a different number and timing of ultrasounds.\nHow many ultrasounds are done during pregnancy?\nAccording to Mendiola, most pregnant women receive two ultrasounds during pregnancy, the first in the first trimester to confirm the due date, and the second at 18-22 weeks to confirm normal anatomy and sex.\nWhat is the time for first ultrasound in pregnancy?\nFirst-trimester ultrasounds are usually performed 7 to 8 weeks after the first day of your last menstrual period, says Rebecca Jackson, MD, assistant professor of obstetrics and gynecology at Thomas Jefferson University in Phil\nHow to confirm pregnancy?\nPregnancy tests detect pregnancy by checking a sample of your urine or blood for a hormone called human chorionic gonadotropin (hCG). High levels of hCG indicate pregnancy.", "label": "No"}
{"text": "DID you know the Government of Gordon Brown spends your tax money poisoning defenceless animals (guinea pigs, rabbits, rats etc) and swabbing burning solvents on to their shaved skin?\nOr that beagle puppies are locked in dimly-lit metal chambers while ruthless researchers pump in deadly pesticides? Or that some laboratory tests kill hundreds of animals every time they are used?\nThese are our modern Dachaus, our Auschwitzes, our Birkenaus, and it has aptly been remarked that if animals had knowledge of religion, they would portray the devil as a man.\nPicture the grief caused by a lethal dose of toxic chemicals being shoved into your pet's mouth. Quite unthinkable! Yet each day we pay - by our choice in cosmetics/pharmaceuticals - to have animals used in tortuous experiments.\nAnimals and human beings are the losers, because every pound spent to harm laboratory animals is a pound that could have - and should have - been used to help people. Surely our ailing social services are more important than cruel and scientifically invalid experiments?\nAled Jones, Mount Crescent, Bridlington, East Yorkshire.", "label": "No"}
{"text": "Buy Panama Red Medicinal Marijuana\nStrain Name: Panama Red\nIs growing Panama red a good weed?\nPanama red is a popular type of weed known for its high quality. It is a Sativa plant that originated in Central America. The plant is tall and thin, with long, narrow leaves. The buds are reddish-brown and covered in trichomes. The THC content of Panama red is high, making it a potent strain. It is a good strain for those looking for a robust and high-quality weed.", "label": "No"}
{"text": "In recent years, fat transfer breast augmentation has emerged as a popular choice for women seeking an alternative to traditional implants. However, like any surgical procedure, it carries its own unique set of potential complications. As we look ahead to 2024, it’s important to understand the risks and considerations tied to this increasingly popular procedure. This article aims to unpack these potential complications, presenting a comprehensive guide for those contemplating fat transfer breast augmentation in the near future.\nOur first area of focus is the risk of infection following the procedure. Despite advancements in surgical techniques and post-operative care, infections remain a potential complication that can have serious implications. Next, we delve into the impact of advanced technologies on fat transfer breast augmentation complications in 2024. With the continuous evolution of medical technology, how are these advancements influencing the risks associated with this procedure?\nThe third subtopic to be explored is the possibility of fat necrosis and related issues. The process of transferring fat to the breasts can occasionally lead to necrosis or death of the transferred fat cells, which can result in a range of other complications. Following this, we discuss the risk of breast asymmetry after fat transfer breast augmentation. While the goal is always a symmetrical outcome, the reality is that achieving perfect symmetry is not always possible.\nLastly, we look at the long-term health implications of fat transfer breast augmentation. While some risks are immediate and evident post-surgery, others may only manifest over an extended period of time. By providing a detailed exploration of these potential complications, we hope to equip readers with the knowledge they need to make informed decisions about their health in 2024 and beyond.\nThe Risk of Infections Following Fat Transfer Breast Augmentation in 2024\nThe risk of infections following fat transfer breast augmentation in 2024 stands as a significant potential complication. This surgical procedure involves the extraction of fat from one area of the patient’s body to be processed and injected into the breasts for augmentation. Like any surgical procedure, it carries an inherent risk of infection.\nThe risk of infection is primarily associated with the surgical wounds created during the procedure. This risk can be amplified by multiple factors such as individual patient health, the sterility of the surgical environment, and the aftercare provided following the procedure. Moreover, the risk of infection isn’t limited to the immediate post-operative period. Infections can occur weeks or even months after the procedure, especially if the patient’s immune system is compromised or if post-operative care instructions are not followed correctly.\nMoreover, fat transfer breast augmentation involves the use of the patient’s own fat, which can potentially carry microbes that may lead to infection. Despite being from the patient’s own body, the extracted fat is not entirely sterile. If the harvested fat becomes contaminated, it could introduce an infection when it’s injected into the breasts.\nAdditionally, the risk of infections following fat transfer breast augmentation in 2024 could potentially increase due to the evolution of antibiotic-resistant bacteria. These bacteria are becoming more common and pose a significant challenge in the medical field. As such, it is crucial for healthcare providers to remain vigilant, uphold strict sterilization practices, and prescribe appropriate antibiotic prophylaxis to mitigate this risk.\nIn conclusion, while fat transfer breast augmentation presents a promising approach to breast enhancement, the potential risk of infection is a serious concern that should be thoroughly discussed with the patient prior to surgery. Patients should be educated on the signs of infection and the importance of post-operative care to reduce this risk. Going forward, advancements in surgical techniques and infection control measures will be critical in minimizing the risk of infections following fat transfer breast augmentation in 2024.\nThe Impact of Advanced Technologies on Fat Transfer Breast Augmentation Complications in 2024\nThe advent of advanced technologies has played a significant role in the medical field, particularly in cosmetic surgeries like fat transfer breast augmentations. In 2024, these advancements are expected to significantly impact the potential complications associated with this procedure.\nOne of the key factors associated with the use of advanced technologies in fat transfer breast augmentations is the precision they provide. This precision reduces the likelihood of surgical errors, which can lead to complications such as asymmetry or damage to surrounding tissues. Advancements in imaging technologies, for instance, allow surgeons to accurately map the area of augmentation, enhancing the precision of fat placement and reducing the risk of complications.\nHowever, advanced technologies also introduce new complexities to the procedure. For instance, the use of automated fat extraction and injection systems may increase the risk of overfilling, leading to excessive pressure on the breast tissues that could result in necrosis or damage to the blood vessels. Furthermore, the adoption of these technologies requires specialized training and experience. If the surgeon is not adequately trained in the use of these technologies, it could increase the risk of complications.\nOn balance, while advanced technologies have the potential to reduce certain risks associated with fat transfer breast augmentations, they also introduce new potential complications. Therefore, it is essential for patients to thoroughly discuss these considerations with their surgeon before undergoing the procedure.\nThe Possibility of Fat Necrosis and Related Issues in Fat Transfer Breast Augmentation in 2024\nFat necrosis represents one of the potential complications associated with fat transfer breast augmentation. This condition refers to the death of adipose tissue, typically resulting from a lack of blood supply, inflammation, or trauma. In the context of breast augmentation, fat necrosis can occur if the transferred fat cells do not receive sufficient blood supply to survive in their new location. This can lead to the formation of lumps or oil cysts, which might be mistaken for a serious breast condition like cancer.\nIn 2024, despite the significant advancements in medical technology and surgical procedures, the risk of fat necrosis remains a concern in fat transfer breast augmentation. This is primarily because the survival of the transferred fat cells largely depends on the body’s ability to supply these cells with enough blood. Therefore, it’s a risk that is inherently associated with the procedure, regardless of how advanced the surgical techniques may be.\nFat necrosis can present various symptoms, including pain, skin changes, and the presence of a lump. In some cases, it might not show any symptoms and may only be detectable through a mammogram or other imaging tests. This can cause significant stress and anxiety for patients, particularly those with a history of breast cancer.\nWhile fat necrosis is typically non-cancerous and can often resolve on its own, it can sometimes require further treatment. This may involve draining the affected area or even surgical removal in more severe cases. As such, patients considering fat transfer breast augmentation in 2024 should be fully informed about the possibility of fat necrosis and related issues, and weigh these potential risks against the benefits of the procedure.\nThe Risk of Breast Asymmetry after Fat Transfer Breast Augmentation in 2024\nThe risk of breast asymmetry represents a critical concern for individuals considering fat transfer breast augmentation in 2024. This procedure, while appealing due to its ability to utilize the patient’s own fat rather than artificial implants, carries an inherent risk of resulting in uneven breasts. This is primarily because it’s challenging to control the exact amount and placement of fat that survives the transfer.\nBreast asymmetry following a fat transfer procedure can occur due to several factors. One is the unpredictable nature of how the body will absorb the transferred fat. Each individual’s body reacts differently, with some patients retaining a high percentage of transferred fat, while others may absorb much of it back into the body, leading to a loss of volume in the augmented breast.\nAnother factor is the skill and experience of the surgeon performing the procedure. The surgeon’s ability to accurately place and distribute the fat cells can significantly impact the final result. If the fat cells are not evenly distributed, it can lead to one breast appearing larger or differently shaped than the other.\nIn addition, individual healing processes and post-operative care can also contribute to breast asymmetry. Swelling and bruising after the surgery can temporarily distort the shape of the breasts. Moreover, how the patient cares for their body post-surgery also plays a role in the final result. For instance, sleeping position, pressure on the breasts, or physical activities can affect the healing process and hence the outcome.\nIn conclusion, while fat transfer breast augmentation offers several benefits, potential patients must be aware of the risk of breast asymmetry. It is essential to discuss these risks in depth with a trusted medical professional before deciding to proceed with the procedure.\nLong-term Health Implications of Fat Transfer Breast Augmentation in 2024\nThe long-term health implications of fat transfer breast augmentation in 2024 is a critical subtopic when discussing the potential complications of this procedure. As medical technology becomes more advanced, we continually gain more insight into the lasting impacts of such procedures. The long-term consequences of fat transfer breast augmentation can greatly affect the patient’s health trajectory and quality of life.\nOne of the significant health implications could be the body’s reaction to the transferred fat. Although the fat is harvested from the patient’s own body, there’s still a chance that the body might not accept the transferred fat cells. This could potentially result in fat necrosis, which is a condition where the fat cells die after being moved. Fat necrosis can cause lumps or bumps in the tissue, leading to discomfort and an irregular appearance.\nAnother potential long-term health implication is the risk of breast asymmetry. While expert surgeons aim for symmetry, achieving it can be challenging due to the unpredictable nature of how the body will accept and integrate the transferred fat cells. This could result in the need for additional procedures to correct the asymmetry, leading to further health risks.\nMoreover, there’s a possibility that the transferred fat might interfere with mammography, an essential tool for detecting breast cancer. Fat cells transferred to the breasts can sometimes appear similar to suspicious cancerous cells on a mammogram, potentially leading to unnecessary concern and further testing.\nLastly, as with any surgical procedure, there’s always a risk of long-term physical and psychological complications. These could include chronic pain, scarring, and dissatisfaction with the results, all of which could impact the patient’s mental health.\nIn conclusion, while fat transfer breast augmentation can offer a more natural alternative to traditional breast implants, it’s essential to consider the potential long-term health implications. Patients must be adequately informed about these possible outcomes before undergoing the procedure. Further research and technological advancements will undoubtedly continue to improve the procedure’s predictability and decrease potential risks.", "label": "No"}
{"text": "What is CBD tea and why is it the best-selling hemp product? In this article, you will learn the CBD hemp tea and 6 best of it that make it what it is - a helper for anyone who wants their body and mind to indulge in peace and regeneration and healing.\nTHE HIGHEST contain cannabidiol CBD\nIt is common for a variety of hemp to be bred in order to have a high share of THC, but this does not concern us. A new trend is the breeding of hemp plants for higher CBD content, the second most important substance in hemp - in terms of therapeutic effect. For example, the Ferimon French variety has over 4% of CBD.\nHarvested at THE LATEST\nWhen it comes to tea with Cannabidiol, the content of the CBD must be at least 1.5% of the CBD. Of course, the more, the better. We will ensure a higher content of CBD by showing a suitable variety of cannabis and later harvesting than is common for hemp tea. So we don’t harvest it after 3 months of sowing, but after up to 5 months when the hemp plant is fully matured. Therefore, the colour is not green, but rather green-brown.\nTHE MOST DISTINCT in flavour\nBy being fully mature at the harvest time the CBD hemp plant is giving the tea a fuller, more earthy and distinct flavour. It is possible and even recommended to mix tea with other herbs as needed. For example, a combination of chamomile or marigold is amazing and versatile.\nTHE STRONGEST in effects\nIf you do CBD tea for the first time, I recommend doing it 1 hour before bedtime and then staying relaxed. The tea has very strong soothing and relaxing effects that induce deep sleep when the body can regenerate and heal itself. You can do it even in the morning when you are full of strength and reflection so that you can better concentrate your mind and calmly feel the new day. I do not recommend making tea after lunch or in the afternoon when classical fatigue is coming, and this condition would be supported. So if you do not plan to relax and have something else to do, wait for the tea for the evening.\nTHE MOST FREQUENT question\nHow can it work when cannabinoids are only soluble in fat and alcohol?\nFirst of all, it is important to mention that hemp is not just about cannabinoids, although they play an important role in its effects on the human body and mind... Tea from hemp also contains terpenes, essential oils and other substances.\nCBD Hemp tea contains hemp seeds, sometimes even crushed. These seeds then contain oil (fatty acids) that are released into the water to help cannabinoids attach better.\nAnd thirdly, it is known that cannabinoids have the ability to dissolve in water to some extent.\nThe preparation of hemp tea is quite easy. Use one tablespoonful, pour 250ml boiling water, and allow to sit for about 5-10 minutes. The longer the sitting will last, the stronger the tea will be.\nFor maximal therapeutic effect, it is recommended to enrich the tea with a piece of butter or a few drops of hemp oil from seeds right at the beginning of the soaking process.", "label": "No"}
{"text": "Originally Posted by Despos\nThe stripe on the flap should align with the stripes below the pocket on the body of the jacket but will not always align with the stripes above the pocket because of the dart.\ni know im reviving this, but rather than make a new thread...\nhow about my coat i got here...\nthe bottom of the jacket aligns with the flap but not with the body above it.\nthe ticket flap though is totally misaligned. can this be an exception or is this an anomaly?", "label": "No"}
{"text": "[Xquartz-dev] xmodmap during in .xinitrc does not stick\ncrestani at informatik.uni-tuebingen.de\nFri Jan 24 05:44:26 PST 2014\n>>>>>\"JHS\" == Jeremy Huddleston Sequoia <jeremyhu at apple.com> writes:\nJHS> If you want to inherit your tcsh environment, then unfortunately, I\nJHS> think the only way would be creating ~/.xinitrc as:\nThanks, that does the trick.\nShouldn't the shell's environment already be there when XQuartz launches\nany of the xinitrc scripts?\n/Applications/Utilities/XQuartz.app/Contents/MacOS/X11 executes the\nright shell and sets up the user's environment. Do the xinit scripts\nget called without inheriting the environment?\nMore information about the Xquartz-dev", "label": "No"}
{"text": "Backyard Springtime Nature in New Jersey.\nThere are plants and flowers that the deer don’t like — daffodils, dandelions, purple crocus, wild violets, and Pieris japonica. I have just planted a number of forsythia and lilac bushes. I hope the deer stay away from them. The flowers in the trees (cherry, plum, and maple) are high enough so the deer are not able to reach. The vegetable garden, tulips and other flowers that I need to worry about are behind an electric fence to deter the deer.\nDaily Power Use (61.6 kWh) and Solar Production (63.6 kWh) from Sense.\nCurrent Weather Conditions\npowered by Ambient Weather", "label": "No"}
{"text": "Vitamin C serum is a skincare product that works effectively to brighten the skin and even out the skin tone. It also contains antioxidant properties that can help to protect the skin from damage. So do you use vitamin C serum at night or day?\nYou can use your vitamin C serum at any time of the day to replenish your skin cells and improve the appearance of your skin. The time you apply the product to your skin determines the kind of benefit you gain from using it.\nFind out what you stand to gain from using it at different times of the day and how to use it correctly on your skin.\nShould You Use Vitamin C Serum in the Morning?\nUse your vitamin C serum in the morning as this is when you stand to gain the most benefit from using it. Use your vitamin C serum in your morning skincare routine before heading out into the sun’s ultraviolet radiation.\nThe serum will work with your sunscreen to help protect your skin from sunburn and other environmental damage. Vitamin C is known to be the best antioxidant to exist in the skincare world.\nUsing the liquid formula on your skin will protect it from harmful environmental elements like sun, pollution, dust, and so on. Those are factors that can make the skin look dull and dry.\nAfter applying your vitamin C serum in your morning skincare routine, be sure to follow up with sunscreen to ensure maximum protection against the sun’s UV rays.\nAnother reason to use vitamin C serum in the morning is the glow it gives your skin when applied. Would you rather get your glow on at the night rather than morning? I bet not.\nNote: Vitamin C is sensitive to sunlight and may get oxidized when exposed. Therefore, ensure that your skin has absorbed the product completely before going out.\nHow Do You Use Vitamin C Serum in the Morning?\nStart by using your favorite cleanser to remove dirt from the surface of your skin. Rinse the cleanser off and apply a toner that works for your skin type. This will help to open up your pores and remove all remaining dirt from your skin.\nAfter toning your skin, you can apply a hyaluronic acid serum to your skin to prevent harsh reactions or irritation from happening. Do this if you have sensitive skin or if you are using a high concentration of vitamin C serum.\nApply a vitamin C serum concentration that works well for your skin type to glow up and protect your skin throughout the day.\nAllow your skin to absorb the serum, then apply a moisturizer that contains sunscreen of SPF 30. This will help to moisturize and protect your skin from the sun.\nCan You Use Vitamin C Serum at Night?\nThe skin naturally repairs itself as you sleep at night. This is when the blood flows to your skin and increases and stimulates the production of collagen and elastin. Those are the necessary proteins needed to repair your skin and eliminate signs of aging.\nUsing vitamin C serum at night will effectively improve your skin as it will assist your skin to repair itself more quickly. It will help provide your skin with additional nourishment to make the repair process faster.\nAnother reason to use it at night is the fact that research suggests that topical vitamin C should be used after exposure to UV light and not before. This is because UV rays lower the skin’s vitamin C level.\nIf your skin is on the sensitive side, it is best to use vitamin C serum at night and not in the morning. This will help to prevent sun sensitivity and harsh reactions.\nNote: After you use the serum at night, ensure you apply a sunscreen of SPF 30 the following morning.\nHow Do You Apply Vitamin C Serum at Night?\nTo use the serum in your bedtime routine, start by cleansing your face to remove all of the dirt and product buildups that has accumulated on your skin throughout the day.\nAfter cleansing your skin, apply your toner to help remove makeup leftover on your face and open up your pores.\nApply a few drops of vitamin C serum to your skin. Squeeze out the serum into your palm and rub your palms together. Apply the serum to your skin while massaging it in a circular motion.\nWait till your skin has completely absorbed the serum and apply a gentle non-comedogenic moisturizer. This will help to moisturize and keep moisture on your skin.\nIn your next morning routine, ensure that you apply sunscreen to protect your skin from sun damage.\nCan You Use Vitamin C Serum Morning and Night?\nYou can use vitamin C in your morning and evening skincare routine if you’d like to get fast results. You get to reap all the anti-aging, protective, and brightening benefits of the serum. However, you don’t have to do this, especially if you have sensitive skin.\nUsing it once is more than enough to improve your skin’s appearance. If you are using a high concentration of vitamin C serum, refrain from using it twice daily. However, you can use a low concentration on your skin daily without triggering side effects.\nAside from that, there is a limit to the absorption of vitamin C in the skin. Once your skin has had enough, the rest will be a waste.\nDo You Use Vitamin C Serum Every Day?\nYou can use vitamin C serum on your skin every day to achieve optimal results. Use your vitamin C religiously to help even out your skin tone, reduce the appearance of aging signs, and give your skin a healthy glow.\nBefore you start using the product on your skin every day, ensure that your skin is already used to it. Don’t rush into using it every day if you are just starting.\nStart by using a low concentration of the serum three times weekly. After a month, you can upgrade your usage frequency and the concentration of the serum.\nFrequently Asked Questions\nShould you apply vitamin C before hyaluronic acid?\nYes, you should. Apply hyaluronic acid serum on your skin before vitamin C especially if you have sensitive skin.\nHowever, if what you have is a thick moisturizer that contains hyaluronic acid, use it after vitamin C serum.\nShould you use vitamin C serum before moisturizing?\nYes, you should. Cleanse and tone your skin, then apply your vitamin C serum before moisturizing.\nThe essence of moisturizing after using vitamin C serum is to moisturize and keep moisture in your skin. Using your moisturizer before the serum will ruin its purpose. Instead, you can apply hyaluronic acid on your skin before vitamin C serum if you have sensitive skin.\nHow long should you wait after applying vitamin C serum?\nWait till your skin has absorbed the serum completely. It takes just about a minute or two for the skin to absorb vitamin C serum.\nEnsure that you wait till that happens before you apply your moisturizing or other skincare products.\nWhat comes first: niacinamide or vitamin C?\nVitamin C serum comes first. Use your vitamin C serum first and let it dry before you apply niacinamide to your skin.\nThis allows the vitamin C to settle into the skin and work before niacinamide without interruptions.\nYou can use your vitamin C serum at any time of the day, either in your morning or evening routine. You can use the serum in the morning before leaving your home to protect your skin from environmental damage.\nLikewise, you can apply the serum at night to help your skin repair itself. However, you don’t have to choose when to use the serum on your skin as you can use it both in the morning and at night. But only if your skin can tolerate it.\nThanks for reading.\nWas this guide helpful? Read more skincare guides like this on Serum101.", "label": "No"}
{"text": "Search the Community\nShowing results for tags '17th'.\nFound 1 result\nGood afternoon I was wondering: Does anyone know some litterature about violin making in the north of France in the 17th- 18th century? I come only across information about Paris and Mirecourt... but i am more interested in the north, i. e: Lille and the part close to Belgium (which was not called 'belgium' yet, of course...), the 'pays bas meridionaux' thank you very much in advance!", "label": "No"}
{"text": "Real Time Monitoring Monitoring\nSo much of what can be accomplished on a farm in one day is dependent on weather. Variables such as wind speed and direction, rain, air and soil temperature can sometimes be the deciding factor of whether to head to the field or keep the equipment in the shed, whether to schedule an irrigation event or shut it down. Site-specific weather data in real-time is a powerful tool for staying on top of growing conditions in a field and planning a work schedule.\nIn 2009, we contacted Spectrum Technologies Inc. and asked them to help us set up a network of weather stations across our farms. A network of seven weather stations spanning a 40-mile radius began monitoring, recording and uploading real-time weather conditions for the 2009 growing season. Cellular connections at each site upload data collected to the Spectrum Weather website where we access our data from wherever we are via an Internet connection.\nSince 2009 we have also been inputting the data collected into crop modeling software to track growth stages of plants to better optimize product applications, irrigation and disease monitoring of crops. Remote access to current conditions at our field locations improves decision making and logistics. As conditions change, we have the information we need to plan an adaptable work schedule.", "label": "No"}
{"text": "Beliefs & Principles\nWe believe all nature’s creatures deserve our respect and protection. Our primary purpose and main concern is to be a Society for the Prevention of Cruelty to Animals…the SPCA .\n- We believe that it is unnecessary to waste a life or cause pain to animals for human entertainment.\n- We believe it is our responsibility to provide adequate food, water, shelter and veterinarian care for the pets in our lives.\n- We believe that the use of animals for medical or commercial experimentation should be strictly discouraged, unless absolutely necessary.\n- We believe that animals for adoption or impound purposes must be confined in a humane manner.\n- We believe that domestic animals must not be permitted to multiple to the extent that may lead to overpopulation and misery.", "label": "No"}
{"text": "Jocelyn Randolph of Rappahannock, Virginia offers this embarrassing tale of her summer vacation!\nLast summer I went to visit my aunt and uncle, who live in an old sugar warehouse in Keesburg. Because there are lots of rats around, my aunt and uncle keep a lot of cats, as well as a sack of rat poison. One day I accidentally put rat poison into the cats’ food dish and they all died. So I took some dead rats and placed one under each dead cat’s head so it looked as though the cats died from eating poisoned rats. My uncle didn’t believe it at all. “We’ll have to find a lighter brand of rat poison,” he laughed good-naturedly, before handing me a spade and telling me to bury the cats. Was my face red!", "label": "No"}
{"text": "Rallying support for economic fairness? Better chase off the needy\nSee the original posting on LA Times Science\nIt is an odd quirk of human nature that humans do not always respond to the misfortunes of other humans in the most humane way.\nA new study tosses some fresh experimental findings for that observation onto a mounting pile of research evidence. Among the affluent plying affluent neighborhoods,…", "label": "No"}
{"text": "Any type of surgery performed on breasts of male or female is termed as Breast Surgery. In cosmetic science, breast surgery is mainly performed to enhance the beauty of female breasts or to reduce the size of male breasts.\nMajor Cosmetic Breast Surgeries performed at TLC Clinique\nTLC Clinique offers a wide range of cosmetic surgeries for breast like:\n• Breast Augmentation – Fat Transfer\n• Breast Augmentation – Silicone Implants\n• Breast Lift\n• Breast Reduction Surgery (Female)\n• Male Breast Reduction (Gynaecomastia)\nAim of Breast Surgery\nEvery cosmetic surgery is performed to improve the aesthetic appearance of the body part. Similarly breast surgeries are also performed to improve the shape, size and appearance of the breast. In addition to this, specific breast surgery has specific aims like:\n• Breast Augmentation surgery is performed to improve the size of breast. It is done either with transfer of fat or using silicone implants.\n• Breast Lift surgery is performed to improve the appearance of sagging or loose breast. It tightens the breast.\n• Breast reduction surgery is performed on both male and female patients who have large breasts. It reduces the size of breast by removing extra fat pockets from it.", "label": "No"}
{"text": "Not known Factual Statements About Golo Diet 101: Pros, Cons, Reviews, Pricing, What To Eat, More\nThey do not have any side effects and this function makes Exipure tablets really safe for utilisation. The leaves of the Perilla plant are made use of in making Exipure capsules.\nIt also contains minerals such as zinc and iron which are really useful for the overall health of the human body. It likewise is fantastic for food digestion and prevents your stomach from being distressed.\nPropolis helps your body in maintaining healthy sugar levels and is among the natural components used to make Exipure pills. It is a natural resin like material that comes from bees and bees extract it from trees. It decreases swelling and assists the body in battling other concerns connected to weight problems.\nIt battles swelling with the aid of its anti inflammatory properties. It likewise has the power to revitalise ageing cells.] B with the assistance of natural formula. All the components are grown naturally before utilisation. All the components used to make these tablets are plant-based and are naturally grown.\nAn Unbiased View of Exipure Reviews – Real Customer Results Or Waste Of Money?\nIn today’s day and age when whatever is offered at a click of a button, individuals tend to end up being lazy. They tend to get accustomed to luxury, be it having groceries, food or clothing delivered right to the doorstep or having ready-to-cook instant food or readily available for immediate consumption or even indicates of transport that are readily accessible.\nPandemic triggered a lot of opportunities to work from house due to which lots of people have actually been accustomed to a sedentary way of life in the convenience of their own homes with very little motions which have actually resulted in a major quantity of weight gain amongst the masses. Operating at a continuous desk job likewise minimizes movements.\nIn men, the decline of testosterone can trigger a rise in cortisol levels which can make the males put on a lot of weight. Increased cortisol levels impact the metabolic rate of the body and result in an increase in fat portion.\nThe thyroid gland launches hormonal agents that assist your body in the metabolism of the food it intakes. When the secretion of thyroid hormone is decreased the body’s metabolic ability minimizes. This condition makes it laborious for the body to burn fat or digest the food taken in which ultimately results in weight gain that further leads to obesity.\nHow Exipure Reviews – Does It Work Or Dishonest Customer Results? can Save You Time, Stress, and Money.\nIf you take in more than the required quantity of fats, sugar, carbs and so on and do not burn all of it through enough physical activity then the excess energy that is formed as a result of digestion and metabolic process of these nutrients gets saved in your body as fat. As this fat keeps on increasing your weight boosts and you end up being obese.\nThey even end up being addicted to it and as you all know, dependency of any form is hazardous to both your body and brain. This addiction results in weight problems. Lots of people also delight in overindulging, be it tension eating or eating simply due to the fact that they are bored. Both these consuming practices also result in weight gain.\nExcessive weight gain may likewise result in many structural and functional damages to the heart. Type 1 is typically caused due to genes and is generally thought about one of the hereditary conditions.\nIn type 2 your body may not produce enough insulin to absorb the sugar which is taken in. In some cases of type 2 diabetes, the insulin that is produced is often unable to absorb the sugar. This increases the risk of getting heart disease or kidney failure or other such serious problems.\nA Biased View of Diet Pills That Work Fast Without Exercise Walmart\nIt has categorised physical appearance based on weight, hair etc. Weight problems does not suit these standards and this may cause serious psychological health problems amongst individuals who are obese or have gained excessive weight. Human beings tend to compare themselves with these appropriate standards of society and this results in anxiety and depression in people struggling with weight problems.\nThe procedure of following these severe measures may likewise cause stress and anxiety, tension and anxiety and disrupt the mental health of an individual being agonised by obesity problems. Individuals try numerous methods to minimize weight be it working out routinely, going on a diet or enjoying what they eat by counting the calories and still, sometimes, do not see correct outcomes.\nThe primary task or responsibility of the brown fat is to burn saved fat and convert it into energy that can be utilised for various activities. Most overweight people are seen to have low levels of brown adipose tissue. Research studies have actually found this brand-new issue due to which weight-loss process becomes hard for people.\nWhile many weight loss diets and supplements exist, not all of them are reliable. A number of cases of overweight people coping with side effects after consuming fad diets and supplements have actually come to light.\nExipure Reviews 2022: Is This Weight Loss Pill … – Health Canal – An Overview\nJack Barrett, and Dr. James Wilkens, 2 noted researchers, are the creators of this supplement. For finest results the developers behind Exipure recommend utilizing the supplement for multiple weeks to see the best results.", "label": "No"}
{"text": "Obesity is not just a disease of developed nations. Obesity levels in some lower-income and transitional countries are as high as or higher than those reported for the United States and other developed countries, and those levels are increasing rapidly. Shifts in diet and activity are consistent with these changes, but little systematic work has been done to understand all the factors contributing to these high levels. The goal of this review is to provide an understanding of the patterns and trends of obesity around the world and some of the major forces affecting these trends. Several nationally representative and nationwide surveys are discussed.", "label": "No"}
{"text": "Coloring Pages Of Animals Dogs\nThis post about coloring pages of animals dogs Publish by Joodie at Friday, Apr 20 2018. Tagged with\nColoring pages of animals dogs have 28 pictures of coloring pages of animals dogs, it's including images like: best printable coloring pages dogs 2018 of animals style and concept, stunning cute animal coloring pages printable for kids picture of dogs inspiration and concept, unbelievable animal coloring funny and cute dog pages for of inspiration trend, the best dogs coloring pages and print picture for of animals concept trend, amazing cute dog animal coloring pages books for print pict of styles and popular, awesome printable dog coloring pages for kids pict of animals trends and concept, shocking puppy and dog coloring pages for of animals concept trends, best dogs coloring pages for of animals ideas and inspiration, inspiring color pages of dogs az coloring image animals concept and trend, shocking dogs coloring pages and print of animals popular ideas, astonishing dogs dog9 animals coloring pages amp book pics of popular and trends, stunning dogs coloring pages and print image of animals style, fascinating printable dog coloring pages for kids image of animals popular and inspiration, fascinating dog coloring pages 2018 dr odd of animals trends and ideas, astonishing animal coloring pages childrens best activities picture of dogs trends and inspiration, stunning printable dog coloring pages for kids pic of animals inspiration and popular, unbelievable dogs coloring pages and print for of animals trend, the best printable dog coloring pages for kids picture of animals inspiration and styles, marvelous coloring pages of dog for animals trends and concept, marvelous coloring pages of boo the dog image animals trend and ideas, fascinating cartoon puppy coloring page for kids animal printables wuppsy image of dogs trends and concept, incredible animal coloring funny and cute dog pages kentscraft picture of styles trend, incredible animal coloring sheets printable for amp boys 8799 dog pages picture of concept and styles, astonishing dog coloring cute little puppy page this picture and all of our other image animals trends concept, astonishing 52 best printable dog coloring pages gianfreda pic for of animals trend and concept, fascinating dog coloring pages 2018 dr odd pict of animals ideas and style, marvelous pet puppy dog coloring 068 of pages animals trend and inspiration,\nFor your information, we've found all of this images from this site. Thank you for visiting coloring pages of animals dogs. Hope you find what you're looking.", "label": "No"}
{"text": "why jihads was not extended to the forest regions\n- when Adama died in 1847, he was succeeded by his son Muhammed Lawal and Zubeira respectively. But they were not of his caliber and were not determined and efficient Warriors. With the attitude of the Fulbe it was difficult to extend the jihadas to the forest region a.g. Mai Bukar recaptured Mandara and it was never part of Adamas with the capital at Yola just because of the poor behaviour of the Fulbes. This means that to maintain ordar in their ranks required a very tactful and competent\nleader. These were qualities Adama’s successor did not have.\n- The Fulani jihadists were interested in the grasslands of the Sudan for the grazing land for their cattles. The forest region of Cameroon had no grazing land and since most of these Fulani depended on cattle farming, they saw no need extending the jihads to the forest region.\n- The forest was a disturbing factor to the jihadists. The thick forest did not only make movement difficult for them but alao led to the fear of wild animals, the malaria carrying mosquitoes and the tse-tse flies which were hostile to the horses and cattle of the jihadists. The jihad horse raiders could not perform well in the forest. But in the north the jihads were easily carried out because of the grassland vegetation which facilitated movement and avoided the risk of wild animals and insects like mosquitoes and the tse-tse flies.\n- The jihadists in north Cameroon had little knowledge of the forest region Cameroon as well as had no close relations with this area. For this reason, it was extremely very diffieult to extend the jihads to this region. On the other hand the close connections Northern Cameroon and Northern Nigeria were very important in the history of the jihads in Northern Cameroon. Both have been parts of the Kanem-Borm Empire, a link which contributed to strong cultural and religious ties. Therefore it was not a surprise that the jihads were extended to Northern Cameroon since they were launched in the Hauea states of Northern Nigeria by Dan Fadio.\n- By the time the jihads had gained grounds in Northern Cameroon, Christianity was also taking a foothold in the forest rogion. Therefore the jihadists discovered that it was not an easy task to overcome the Christian population of the south to implant Islam. As result, the jihads were limited to the Northern part of the country.\n- By 1847 when Adama died, a greater part of the objectives of the jihadists had already been attained. Further extenaion of the jihads into the forest region appear unnecessary\n- Resistance from Bamum, led by King Mbwe-Mbwe and the Gbaya groups also stopped the southward movement of the jihadists. King Mbwe-Mbwe dug trenches and made fortifications around town which rendered movement very dificult for the fulani horses.", "label": "No"}
{"text": "I went out to water the plants and trees with a flock of little helpers 🙂 Cutter and Smacker jumped right into the mud and had a blast.\nCutter is the worst little mud puppy\nSo we filled the pool to clean all the pups\nAiden usually stands outside the pool and just bites the water…. he actually got in the pool today!\nFun to watch each pup figure out if they like water or not. Demian jumped right in – Shady, not so much\nFreeway got in on the fun too – She really likes the littles.\nDemian was clever at her new trick\nShimmer really likes Freeway and kept trying to get her to chase her\nThis is the dirtiest that Shady got – He is happier to just pose and look cute 🙂", "label": "No"}
{"text": "A wolf is a highly intelligent and social sentient being. The amount of torture that trapped wolves are subjected to is immeasurable. Yet, despite massive public input in defense of wolves, the Montana state Fish, Wildlife and Parks Department (FWP) just added them to their long list of species that can be “lawfully” targeted by trappers. Ignoring record-breaking outcry, the FWP Commissioners have approved their wildlife agency’s extreme “bag limit” of two wolves tortured to death per trapper, in addition to the ones they’re already allowed to hunt. What this means is that each individual “sportsman” can legally kill THREE wolves – two by trapping and one by shooting.\nAnyone who has seen the harrowing ordeal suffered by an animal caught in a leg-hold trap would be appalled and outraged that trapping is still legal in states like Montana. But trappers have no qualms about the cruelty they inflict. Just ask the vice president of the Montana Trappers Association:\n“We trappers do cause pain and suffering to animals and apologize to no one.” Guys like this must have an over-inflated sense of entitlement to publically blurt out something this shallow, narcissistic and utterly absent of regret.\nNot to suggest they’re psychopaths or anything, but grandiosity and the lack of remorse, guilt or empathy are all key traits of psychopathy…\nIf society were ever to practice pre-emptive incarceration based on a given person’s potential to do harm to others, trappers would be the first to go.\nFor more info on the approved wolf hunting/trapping proposal, see: http://helenair.com/news/local/govt-and-politics/fwp-allows-trapping-of-wolves/article_fd2d21f2-ccb1-11e1-a3ce-001a4bcf887a.html\nIf you’re not happy about this, MONTANA’S GOVERNOR BRIAN SCHWEITZER would love to hear about it. He can be reached at: 406-444-3111 – or via Email: email@example.com", "label": "No"}
{"text": "An anomalously high saturation value for the decay constant of the 'alignment' is observed for coherence-narrowed 61S0-6 3P1 198Hg fluorescent radiation scattered at right angles from the frontal region of the resonance cell. This is explained in terms of the radiation loss from the front face.\n|Number of pages||6|\n|Journal||Journal of Physics B: Atomic and Molecular Physics|\n|Publication status||Published - 1970|", "label": "No"}
{"text": "Dr. Xiaomao Lin headed a U.S.-China Scientific Cooperation Exchange Program (SCEP) funded by USDA to visit China. The SCEP program is to support collaborative relationships between teams of scientific and technical experts from the United States and the People’s Republic of China. The program helps to promote U.S. agricultural priorities, encourage long-term cooperation in agricultural science and technology, create a positive atmosphere for agricultural trade, and enhance overall relations between the United States and China. Besides Dr. Lin, the KSU team included Kraig Roozeboom, Deann Presley, Robert Aiken, and Zach Zambreski, all in the Department of Agronomy.\nThe theme of this SCEP project for the KSU team is “Adjusting Agricultural Practices in Response to Environmental Change – Climate Resilient Agriculture”. One goal was to exchange knowledge on the impacts of environmental changes on crop production and on practices and climate-informed tools under development to increase resiliency in corn, soybean, and wheat production systems. The other was to explore collaborative priorities and mechanisms for ongoing U.S.-China cooperation on challenges to production of these crops, particularly as presented by environmental changes. This would include development of ag-climate risk monitoring tools through integrating soil health, water and nutrient management, crop modeling, and climate information. The team visited with the Faculty and Administrators of three Agricultural Universities and Scientists of the Chinese Academy of Agricultural Science.\nThe presentation included an overview of major Innovation Labs hosted by the K-State College of Agriculture; recent evidence of climate change and impacts in the U.S. Great Plains; effects of water limitations on productivity of wheat and new approaches to identify varieties with enhanced water productivity; tillage impacts on soil erodibility and benefits of cover crops for soil protection, nutrient management, and improving cropping system resilience.\nHighlights of information gained from discussions and field trips include appreciation for the contribution of intensive management for high-yielding maize, soybean, and sorghum production managed by the National Farms in northeast China; the challenge of labor productivity in intensive small-holder cropping systems; opportunities to increase land productivity with relay and intercropping techniques in southwest China; recognition of the expansion of triple-cropping and double-cropping systems towards the north of China; and use of simulation techniques to quantify yield gaps and their interactions with climate change.\nFuture plans include recommendations to pursue memorandums of understanding with the Chinese universities in order to facilitate short-term student and faculty visits; undergraduate and graduate training programs; and joint research collaboration in drought monitoring and mitigation, yield gap analysis, intercropping opportunities and soil management.\nThe KSU team is preparing audio-visual presentations for our departments and colleges, as well as printed material suitable for newsletters of our professional societies. Dr. Zheng of BYAU is among the scientists we visited who is planning to travel to the US for scientific meetings in January, 2018 as well as a possible visit at KSU.\nAdditional information on the project can be found in the KSU 2017 SCEP Report Submission.\nXiaomao Lin, Agronomy\nZachary Zambreski, Graduate Research Assistant\nMary Knapp, Weather Data Library", "label": "No"}
{"text": "Stanescu, M.D., Anselm A. Zdebik, M.D., Ph.D., R. Krishna Chaganti, M.D., Robert L. Nussbaum, M.D., Robert Kleta, M.D., Ph.D., William A. Gahl, M.D., Ph.D., and Manfred Boehm, M.D.: NT5E Mutations and Arterial Calcifications.. Cynthia St. Hilaire, Ph.D., Shira G. Ziegler, B.A., Thomas C. Markello, M.D., Ph.D., Alfredo Brusco, Ph.D., Catherine Groden, M.S., Fred Gill, M.D., Hannah Carlson-Donohoe, B.A., Robert J. Lederman, M.D., Marcus Y.After several years of eating foodstuffs that are rich in fats, high sodium sugar and foods, most individuals opt to go on a diet plan but they do not succeed by the end. Maintaining an inclusive nutritious diet not only provides the body with energy and diet that it needs to function well, but also provides many health benefits as well. Below are some benefits of eating healthy. One of the benefits is that you will maintain a wholesome weight.", "label": "No"}
{"text": "Yellowtail fish is a perplexing name, since it may refer to flounder, tuna, and sole. It’s also the popular name for various species of amberjack that resemble sleek migrating tuna but are native to both the Pacific and Atlantic Oceans.\nYellowtail meat is often pink, although wild yellowtail can be various colors owing to varying fat amounts among fish. Because it is high in fat, farmed yellowtail is always light in color.\nA red or pink tint may be seen in the flesh of yellowtail fillets. Along the edge, a dark muscle line might be evident. The meat is white and firm with a pleasant, mild flavor that has been cooked. The high oil content gives it a luxurious feel.\nThe Most Prized Yellowtail Fish\nLike bluefin tuna, the yellowtail fished in Japan and sold in American sushi restaurants under the name hamachi is the most important member of this family.\nThe fish is prized for eating raw and commands a premium price in Japanese markets. Raised in cages in Japan’s Inland Sea, hamachi are harvested at around 15 to 20 pounds. The fish are frozen and handled with care after harvesting to avoid bruising the flesh, which lowers its sashimi value.\nThe hamachi is caught in the wild off the coast of central Japan. Another yellowtail species, Seriola lalandei, is captured in the wild off southern California and Baja, California and farmed in Mexico and Australia.\nIn the wild, amberjacks are susceptible to parasite infestation, but this does not apply to farmed hamachi.\nA Delicacy in Winter\nIn the past, yellowtail fish was a winter staple as they have more fat throughout the winter. Depending on their weight, they are either referred to as hamachi or buri inJapanese.\nThey are most frequently caught in Horukku and Toyama. Typically, sea farmers pick up fish eggs hidden beneath seaweed each May. They are then sold to aquaculturists, who raise them until they reach three kilograms (when they are called buri) or five kilograms (when they are called hamachi).\nHow to Prepare Yellowtail Fish\nYellowtail fish is prepared in a variety of recipes by chefs. The fish is served raw and chopped into thin strips in Korea.\nAfter that, you put the fish inside lettuce or fragrant sesame leaves, add some garlic and chili paste, and then wrap it all up. Chefs in Japan use a wide range of cooking methods. A delectable soup made with lightly fried yellowtail fish is frequently prepared.\nYellowtail sashimi, on the other hand, is most familiar to us. You have the choice of eating it nigiri or in a roll, where it can be combined with a range of vegetables including cucumber and avocado and different sauces.\nYellowtail Fish Health Benefits\nWhen it comes to fish, fat is a good thing. Yellowtail fish is an amazingly high source of protein, and it is one of the best sources of omega-3 fatty acids.\nThese are the healthy fats that are packed with a wide range of benefits, including reducing blood pressure, decreasing inflammation, and even improving mood. It’s also high in Vitamins B12, B6, and selenium, as well as other minerals.\nThe Best Way to Enjoy Yellowtail\nThere are a lot of different serving choices available giving one a large scope of choice. Each fish has its own distinct flavor that must be tasted to be believed. Therefore, people choose to combine it with other fish, such as salmon, tuna, and mackerel.\nYou’ll want to try a variety of different items to see which one you enjoy the most. Most people like combining the fish with sake, beer, or green tea as a complement. Take pleasure in how the chef combines the ingredients to fully appreciate the fish.\nThere is no one-size-fits-all approach to sushi dining. If you like, add soy sauce, wasabi, or even hot sauce. The greatest thing you can do is inquire with the chef as to what they believe is the finest way to eat the fish. It varies from person to person based on how it’s cooked and personal preference.\nYellowtail Fish Recipes\nThere are some many great ways to eat Yellowtail whether it’s raw or cooked. Below you’ll find links to a number of really tasty yellowtail fish recipes.\n- Pan-fried Yellowtail with Lemon and Parsley\n- Yellowtail Ceviche\n- Broiled Yellowtail Collar with Daikon\n- Yellowtail Scad Fish-fry With Cucumber And Iceberg Salad", "label": "No"}
{"text": "Why You Should Make Your Own Fruit Cocktail!\nDo you remember those small cans of fruit cocktail that were often thrown onto your cafeteria tray by the elementary school lunch lady? The all too soft peaches, pears, pineapples and wrinkled grapes that were drowning in a thick overly sweetened syrup. And let’s not forget about the one or two cherries that were hidden in the mix and that brought such joy to our six-year-old selves! If we were lucky enough to get one more bright red cherry than our buddy sitting next to us it was “the best day ever!”\nAnd mom felt good about the fact that we were getting a good serving of fruit with our lunch each day. Unfortunately though, what she didn’t know at the time was that the sweet sauce that the fruit was swimming in took away any health benefits that could have been provided by the bite-sized pieces of fruit.\nToday we have a much greater understanding of the hazards of many of the ingredients contained in these snacks that were once considered a “health food.” For example, many of these cans of fruit contain syrups made from high fructose corn syrup which has been linked to obesity, diabetes, high triglyceride levels and cardiovascular disease, and corn syrup produced from genetically modified seeds with unknown long-term effects. And those ruby red cherries that we sought out – well they have likely been processed with artificial preservatives and then injected with FD&C Red No. 4 to give them their bright red color. Many studies have linked FD&C Red No. 40 (and other artificial food dyes) to hyperactivity, cancer, and allergic reactions.\nWhat about those packed in juice rather than syrup and sans the artificial coloring? Sounds like a good option, but many of these contain a high amount of added sweeteners including Ascorbic Acid which research has suggested may cause cancer. And once again the mysterious ingredient that goes by the name “natural flavor” is found on many of the labels. Does anyone actually know what “natural flavor” consists of?\nHow about the sugar-free variety? Unfortunately, this is not a good option either. Many of these options contain Ascorbic Acid as well as Acesulfame Potassium, an artificial sugar which research has also shown to possibly cause cancer, and Sucralose (marketed under the name Splenda), which has been linked to a number of adverse health effects including migraines, gastrointestinal disturbances, allergic reactions, acne, dizziness and weight gain.\nNow, knowing that the options of years past are not the healthiest, why not spend a few extra minutes in the kitchen (and I really mean just a few!) and make your own fruit cocktail? This is an especially good option now that we have entered the summer months when there are so many fresh seasonal fruits to choose from in your local grocery store or farmer’s market! Change it up from week to week as new fruits come into season!\nThis colorful cocktail contains layers of fruit soaking in a naturally sweet and spicy dressing and can be eaten as a healthy and satisfying snack, a light nourishing breakfast, or can even be served at the end of a perfect meal. The fruit, of course, provides a natural source of essential vitamins, minerals, and dietary fiber, all of which are crucial for the proper functioning of the body. They also contain antioxidants and phytochemicals (chemicals produced by plants) which have been linked to a reduced risk of many chronic diseases.\nThe addition of Ginger only increases the health benefits! Ginger is a good source of Vitamin C, Potassium, Omega-6 Fatty Acids, Omega-3 Fatty Acids, Copper, and Magnesium. Historically ginger has been used for medicinal purposes, particularly fighting inflammation. It is a known natural antibiotic, antimicrobial and anti-inflammatory compound that can ease pain and decrease congestion. Ginger is used by many suffering from arthritis. It is also a remedy for nausea and motion sickness. Studies have shown that ginger decreases inflammatory substances associated with various cancers, including colorectal and ovarian.\n- 4 cups diced fruit and/or berries such as pineapple, mango, watermelon, grapes, blueberries, strawberries.\n- 6-10 mint sprigs\n- 1 tsp. organic sugar or coconut sugar\n- Juice and grated zest of 1 lime\n- 1 Tbsp. water\n- 1/2″ piece of ginger grated\nIn a food processor combine strawberries, sugar, lime juice and zest, water and ginger. Blend until a puree consistency. Add additional water if necessary.\nTo make 4 on-the-go servings, evenly distribute puree in 4 12-ounce sized containers. Alternatively, the puree can be evenly distributed in 2 24-ounce sized containers to be shared.\nLayer fruit on top of the puree until the jar is almost full and top with a mint sprig.\nCover jar and refrigerate for at least two hours. Gently shake the jar to distribute the puree before serving. It can be stored in the refrigerator for up to 2 days.\nAnd don’t forget the importance of using organic produce in order to avoid the health hazards associated with pesticides and other poisonous chemicals found in commercially grown food. Remember, healthy soil breeds healthier plants. In other words, organically grown produce not only contains more nutrients but also, and most importantly, tastes better!", "label": "No"}
{"text": "Losing weight is not vanity, it’s a life necessity!\nTake this easy and important step towards your health and the best version of yourself. Keto Life Coach will change the way you view and experience food.\nWhat is keto?\nKeto is a diet that works for everybody, following a very simple protocol. A ketogenic diet is not new, it is not a fad diet, and it is not expensive. It is a sustainable, and delightful way of eating that your body will love.\nThe diet works by forcing your body to use fat instead of ingested carbohydrates for fuel. In a nutshell, you will be losing weight rapidly, with no hunger and you will feel great long-term benefits in a sustainable way.\nOn top, the byproduct of burning fats are ketones, which are a great source of energy for your brain.\nAbout the workshop\nYou will learn about the most effective way to look after your body and your health. You will learn why (and how) you can shed body weight without exercise in keto, and how to optimise your well-being.\n- Introduction to the Ketogenic Diet\n- What is Keto\n- Why (and how) does the diet work\n- The danger of carbohydrates\n- Sugar and inflammation\n- What to eat\n- How to deal with cravings\n- How to enhance results\nKeto is for those who\n- want to lose weight quickly; are insulin resistant or borderline diabetic;\n- want to transform their metabolism and dramatically make a positive change to their lives;\n- want to reduce the risk of metabolic syndrome such as diabetes, cardiovascular disease, high blood pressure, high cholesterol;\n- want optimum health & well-being at any stage of their lives.\nWho’s the coach?\nMy name is Ana. I’ve read psychology at the University of Liverpool and then furthered my interest in human behaviour at postgraduate level in counselling at the University of Chester.\nAfter 3 years of research and self-experimentation I have mastered the challenges of reaching optimum health. I will give you the practical advice you need from the vast amount of research behind the ketogenic diet. I will guide you through the process, in a way you feel most comfortable with.does bring many other benefits!", "label": "No"}
{"text": "A method for thermal ramp experiments on cylindrical 18650 Li-ion cells has been established. The method was applied on pristine cells as well as on devices aged by cyclisation or by storage at elevated temperature respectively. The tested cells comprise three types of LiNi0.8Co0.15Al0.05O2 cells for either high power or high energy applications. The heat flux to and from the cell was investigated. Degradation and exothermic breakdown released large amounts of heat and gas. The total gas and heat emission from cycled cells was significantly larger than emission from cells aged by storage. After aging, the low energy cell ICR18650HE4 did not transgress into thermal runaway. Gas composition changed mainly in the early stage of the experiment. The composition of the initial gas release changed from predominantly CO2 towards hydrocarbons. The thermal runaway emitted for all tests a comparable mixture of H2, CO and CO2.\n|Number of pages||10|\n|Journal||Journal of Electrochemical Science and Engineering|\n|Publication status||Published - 2018|\n|Event||Regional Symposium on Electrochemistry of South-East Europe 2017 - Telekom Hotel Balatonkenese, Balatonkenese, Hungary|\nDuration: 11 Jun 2017 → 15 Jun 2017\nFields of Expertise\n- Mobility & Production", "label": "No"}
{"text": "5 Easy Facts About Irritable Bowel Syndrome Diet DescribedConsider limiting fruit ingestion to no more than a few parts each day. Have only a single small glass (a hundred and fifty ml) of fruit juice daily. Getting far more vegetables might help to satisfy the recommendation of at least 5 portions of fruit and veggies every day.\nTo recognize food stuff triggers, your medical doctor may perhaps counsel that you just keep a meals diary and stay away from foods that lead to indications. Regulate worry and anxiety, and check out cognitive therapy or psychotherapy if desired.\nThis details is by no means intended to replace the guidance of your respective doctor. We advise viewing a health practitioner Each time a wellbeing problem arises necessitating a professional’s care.\nSome individuals have gluten intolerance with no immune reaction or improvements in the intestinal cells. This is recognized as non-celiac gluten sensitivity.\nGenerally speaking, there are few complications associated with this purposeful disease other than the symptoms of your disease alone.\nMuscle mass contractions inside the intestine. The partitions from the intestines are lined with levels of muscle mass that contract since they move meals by your digestive tract.\nIf I have IBS, just how long will it consider for me to determine advancement with the therapy you have got prescribed?\nDigestive enzyme nutritional supplements are one of many intended treatments for alleviating tummy troubles. But do they get the job done?\nConsume a reasonable volume of foods which have been better in the sugar substitute sorbitol, including dried plums and prune juice.\nIf dietary modifications and lifestyle modifications do not sufficiently address the signs click here or symptoms and indications, a doctor might recommend professional medical therapies.\nIf you must eliminate dairy completely to make your life additional comfy, contemplate asking your doctor if you want a calcium supplement.\nAmong the most typical queries IBS patients have is exactly what foodstuff in order to avoid. This may drive a person to go hunting for a diet or perhaps a take a look at that might aid type all this out.\nYour health practitioner may possibly get a breath exam or inquire you to get rid of milk and milk items out of your diet for numerous months.\nSome people swear by their morning espresso for digestive regularity. But like all caffeinated beverages, coffee incorporates a stimulating impact on the intestines that can result in diarrhea.", "label": "No"}
{"text": "Doctor insights on:\nLung Cancer Xrays\nCan lung cancer ever appear on an xray, be diagnosed as pneumonia and then not appear on two subsequent xrays or was it really pneumonia.\nCancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more\nI just had an angio pulmonary cat scan with contrast to rule out a pulmonary embolism. Can that detect lung cancer? Chest xray normal. 42 years old.\nYes,: that type of CT can detect lung cancer. Tiny nodules 2mm or less can potentially be detected. There are benign causes for nodules as well, so although CT is good at finding nodules, and possibly assigning a reasonable probability of malignancy based on certain imaging features, CT cannot make a definitive diagnosis of cancer. ...Read moreSee 3 more doctor answers\nCan shortness of breath be the only symptom of lung cancer...had clear chest xray and 2 negative d dimers (all 3 in December)...scared!\nLiklihood of a 25 yr old having lung cancer after clear chest xray, lungs sound clear, coughed up decent streak of blood, clearing throat alot?\nIt varies: It can be a mass, or unusual calcifications, or an unusual \"infiltrate\" on a chest x-ray. In other words, it can have many different appearances. A chest x-ray is a great tool, but it takes skill to interpret. I do not recommend you try to interpret your films, but your doc can review it with you to give insights. Hope this helps. ...Read moreSee 1 more doctor answer\nWeeks to months: There is no hard and fast rule. In studies that tried to detect lung cancer early using a chest x-ray, almost half of the cancers appeared within a year of a normal x-ray. Taking into account the rate of growth of a cancer cell, and the minimum size needed for detection on x-ray, a good estimate for small cell is a few weeks to a few months. ...Read moreSee 3 more doctor answers\nCould lung cancer (of any type) not show up on an X-ray after 14 months of symptoms?\n(Theoritical question not for diag.)\nYes: Especially, adenocarcinomas in the apex can be very small and hide behind other structures. ...Read more\nWhich type of specialist can test me for small cell lung cancer (the types of lung malignancy that cannot be seen on xray)?\nPulmonary: If you have some cause or reason, symptoms that would in any way cause concern for a possible lung cancer, than a lung specialist (pulmonary dr.) would be able to diagnose a you accordingly, which may include a history and physical examination, possible testing including labs, x-rays, and possible diagnostic bronchoscopy. ...Read moreSee 1 more doctor answer\nSometimes: Sometimes 8-10 mm lung lesions can be detected. Detection depends on location of lesion whether it is central or peripheral. Central lesions near mediastinum are many times difficult to recognize on plain radiograph. Cross sectional imaging such as CT is much more sensitive for small hidden lesions than radiograph. ...Read moreSee 1 more doctor answer\nNo: This x-ray is too limited. We have proven a ct of the chest is very helpful in screening for hi risk people though you don't fit age (55 to 74 who smoked > pack of cig/day for >30 ys and who are still smoking or who <15 yrs ago). Smoking volume history, infections and other factors should be considered before scans. With suspicion your primary md may still start with a chest xray before ct. ...Read moreSee 1 more doctor answer\nIt might--or not: Advanced lung cancer would show on x-ray. Earlier cancers are better seen with ct scans. If you have been a heavy smoker for 15 or more years, your risk is certainly much higher of a cancer than a non-smoker. Non-smoking related cancers occur, but usually in much older individuals. ...Read moreSee 1 more doctor answer\nIf I have chest pain and my X-ray was clear do I need to worry about lung cancer why would a tumor not show?\nMany causes of Pain: Pain in the chest can be caused by many different reasons. Lung cancer can be one of these but it will often produce other symptoms such as cough and shortness of breath. If a chest X-ray is normal then you are not likely to have any tumor in your lungs. Other reasons to exclude is Angina(although it is a disease of the older people) or muscular pain(this is the most likely reason). Such pains go ...Read moreSee 1 more doctor answer\nIf your having chest pain and worried about lung cancer wouldn't the tumor be big enough to show on a X-ray if having pain?\nIf you had lung cancer that has spread to other parts of your body would it probably be big enough to be seen on X-ray or your blood work be off?\nYes and no: When Cancer starts to spread, it begins as clusters of cells that form tiny colonies in other body parts. These will grow in size over a few months to become visible on X-rays and various diagnostic imaging tests such as CT scan and or PET scan. Blood tests do not show cancer cells , so we rely on the above imaging tests and repeat them periodically(every 2-3 months) to monitor for the tumor growt ...Read more\nDeoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more\n- Talk to a doctor live online for free\n- Will chest xray show lung cancer\n- Can a xray show lung cancer?\n- Can a xray miss lung cancer?\n- Ask a doctor a question free online\n- What does an xray look like for lung cancer?\n- Lung xray shows pleural thickening is that precursor to cancer\n- What does lung cancer look like on chest xrays?\n- What does lung cancer look like on a chest xray?\n- Talk to a oncologist online for free", "label": "No"}
{"text": "All the News that Matters\nin Organic Fresh Produce\nOPN Connect Newsletter 163\nAwe Sum’s David Posner, Organic CA Grapes, Alltech, White Buffalo Land Trust, and More...\nIn early 2018, Steve Finkel founded the White Buffalo Land Trust, a nonprofit organization dedicated to regenerative agriculture. Its first property, a 12-acre legacy avocado orchard in Summerland, CA, serves as the nonprofit’s flagship location. Primarily a demonstration and educational site, the Summerland ranch showcases regenerative organic ag techniques including multistrata agroforestry, composting, cover cropping, the creation of pollinator habitats, and holistically managed animal grazing.\nTo David Posner, founder, CEO and president of Awe Sum Organics, challenges always bring opportunities, and such is the case with the novel coronavirus, Covid-19, currently sweeping the globe.\nWith a mission to improve the health and performance of people, animals and plants through nutrition and scientific innovation, Alltech was founded in 1980 by Irish biochemist Dr. Pearse Lyons. The Lexington, KY-based company develops agricultural products for use in both livestock and crop farming, as well as products for the food industry, helping farmers to feed the world, raise healthy plants and animals, and protect the environment through nutrition and scientific innovation.\n1. Stemilt Helps Retailers Zoom Into Cherry Season\n2. Delilah Romo joins Pacific Organic Produce\n3. Attune Agriculture Announces Ampersand® Adjuvant Available in CA\n4. Grimmway Farms Ready to Ship Cal-Organic Potatoes\n5. NOSB 2020 Spring Meeting", "label": "No"}
{"text": "Dear KiteGen followers,\nBelow you can find one of our interactive presentations about different aspects of KiteGen technology. This particular on describes the origins of the idea and how the KiteGen STEM works.\nThere are several of these work in our Webinars section (password protected), to access that section contact us.\nto visualize it you might require Adobe Shockwave\nPresentations developed by Ing. A.Papini", "label": "No"}
{"text": "Proper pond administration methods near Alba need to constantly start with an analysis as well as inspection of the current conditions in the pond. This web page talks about several of the important components of a regular fish pond that should be recognized and evaluated before tackling fish pond monitoring concerns.\nAn essential initial step in examining your pond is to identify the key purposes for your fish pond and also comprehend the limitations this will put on other usages. Ponds are frequently used in several means to please greater than one purpose. For instance, having water readily available in the pond for fire security could please one goal without conflicting or conflicting with various other goals such as swimming or fishing. Numerous usage fish ponds are great as long as the usages work. When clashing or inappropriate uses are desired, it is necessary to appoint concerns to the proprietor’s goals. For example, the goal of providing for swimming might contrast straight with the goal of having water available for irrigation. Watering requirements might lower the water degree to a point where swimming is impossible, at a time when swimming is most wanted. For this reason, you should detail and also prioritize certain objectives for your pond. Evaluating the pond resources is an essential element of establishing purposes. With evaluation as well as evaluation of the fish pond framework, landmark, water resources, and ecology, you can guarantee that the fish pond sources suffice for your objectives.\nNumerous pond usages and management methods will need an understanding of the local Illinois pond watershed as well as sources of water. The fish pond landmark includes the location of land surrounding the pond that contributes water to it. Identifying the pond watershed is very important because anything that occurs within this area can impact the pond. Situating a fish pond in an undisturbed location or decreasing disturbance and also land utilize changes within the pond landmark are essential parts of safeguarding a fish pond.\nNumerous fish ponds have been built where groundwater comes to the surface area as springtimes or seeps. Ponds fed by these groundwater sources might stay cooler during the summer season particularly if the circulation from the springtimes is persistent. Preferably, the land area adding water to the springtimes must be determined and secured to make sure adequate amount and also top quality of water for the fish pond.\nOften fish ponds are built on or near a surface stream. The stream might merely move through a created fish pond or a part of the stream may be diverted into the fish pond. In this local Alba instance, the fish pond’s wellness relies entirely on the quality as well as amount of stream water. The entire acreage draining the surface stream comes to be crucial to the health and wellness of the pond.\nWhere Illinois groundwater or streams are not readily available, a pond might lie to record surface runoff from the surrounding land. Surface area runoff ponds are normally located in anxieties typically draining 10 to 20 acres of land for a one acre fish pond. Land use activities around these ponds is especially important considering that water moves directly over the land to the pond. Treatment ought to be taken to prevent contaminating activities on the land around these ponds.\nRegardless of the water resource in Alba, it is a great idea to establish a barrier strip of plants around the pond to catch debris, nutrients as well as other toxins prior to they go into the fish pond. The buffer strip must range in size from 10 feet broad (for a mild incline) to 50 feet broad (for a steep slope around the fish pond).\nAt the very least as soon as every year you need to take some time to check the pond framework. Regular inspection and also constant upkeep secures a pond, keeps it appealing, and extends its beneficial life. Lack of assessment and also prompt repair service of issues might cause extra serious damage that is either irreparable or more expensive to deal with.\nA Illinois dam and also any type of subjected financial institutions must be inspected to make sure that they have complete turf cover as well as no disintegration. Lawn, weeds, brush as well as tiny trees must be periodically reduced from the dam and financial institutions. Cutting smaller greenery permits a visual inspection of the surface area to look for indications of leakages or delving animals. Likewise inspect as well as fix any type of fencings that are utilized to keep livestock from accessing the dam or pond embankments. Huge trees currently existing along the dam or financial institutions ought to be laid off. Cutting or killing big trees might create leaks to establish around their decaying origins.\nThe pond water level must be regularly observed to keep an eye on for very early signs of leak. The majority of ponds shed some water to below ground infiltration and dissipation. Ponds with little water inflow may lose several inches per day to dissipation in the summer season. Losses more than this may be credited to a considerable leakage that is commonly visible as a wet area outside the pond. Leaks may originate from muskrat burrows, rotting origins, or debris left in the fish pond dam. If you think your fish pond is leaking, consult Fixing a Dripping Pondto learn more concerning methods to take care of leaks.\nA common issue among older ponds is sedimentation. Depending upon the source of water, fish ponds might fill up over time with sediment. As debris completes the pond, growth of marine plants and algae will usually raise, as a result of raised sunlight passing through the shallower water.\nSediment degrees in the fish pond need to be observed and also kept an eye on. If sedimentation is obvious, actions need to be taken to reduce debris entering the fish pond. Inspect the pond water source to figure out if subjected banks or upstream tasks are triggering enhanced debris. If the pond gets excessive amounts of silt, disintegration control practices ought to be applied in the landmark. If you do not own upstream land, a tiny resolving container just upstream from your pond can be built to intercept silt or particles. Debris could be gotten rid of from the pond via dredging yet this procedure is typically time-consuming, pricey, as well as devastating to pond ecology.\nPonds, like any kind of body of water, attract both invited and also unwelcome individuals. As part of your fish pond evaluation, think about safety and security features and also devices to safeguard site visitors. Eliminate trees, stumps, and also brush which may be a danger to swimmers. Keep the fish pond as well as banks free of rubbish, cable, coulds, containers, as well as various other particles. Mark the swimming location as well as article safety policies for all permitted water usages. Area warning signs in all recognized threat spots. If boating and also swimming are permitted, take into consideration building a dock or pier. Connect lifesaving gadgets such as ring buoys, ropes, or long posts to a safety and security message located near swimming areas. To learn more on fish pond safety and security problems and also equipment, get in touch with the websites entitled Ranch Pond Security.\nAlong with security tools, several fish pond owners choose to lug thorough responsibility insurance policy on their building. You ought to speak with an attorney and an insurance agent for correct interpretation as well as protection for the specific circumstances entailed with your fish pond.\nOther areas of pond evaluation consist of mindful measurement of pond location and quantity. For even more details on how to do this, seek advice from Measuring Pond Location as well as Quantity.\nPond assessment must consist of regular screening of the pond water top quality. Water tests are helpful to record existing troubles and also to check for essential changes in water quality. The criteria that need to be examined in your pond will certainly depend upon your desired usages for the fish pond. For more details on fish pond water top quality, consult Water High quality.\nRecognizing and also inventorying the aquatic plants as well as algae expanding in the pond during the summertime is valuable to figure out the existing health of the pond and also prospective issues in the future. Speak With A Guidebook to Common Marine Plants for photos and drawings of typical marine plants as well as algae that may assist identify plants in your fish pond.\nAnalysis of existing fisheries in the pond is very important for future administration choices pertaining to equipping, harvest, as well as habitat requirements. Fisheries assessment is achieved mostly by records kept by fishermen and aesthetic monitorings of numbers and also sizes of fish from the pond bank. Expert fisheries biologists can also be worked with to perform electrofishing studies of fish ponds and also lakes to supply more comprehensive assessment information as well as management strategies.\n[ssvideo keyword=”Lake” title”Fishing in Alba”]\n[ssplaces location=”Alba IL” keyword=”Weed Control” limit=”7″]", "label": "No"}
{"text": "(An)isotropy of the Hubble diagram: comparing hemispheres\nFakultät für Physik, Postfach 100131, Universität Bielefeld, 33501 Bielefeld, Germany e-mail: [dschwarz;bwein]@physik.uni-bielefeld.de\nAccepted: 28 August 2007\nAims.We test the isotropy of the Hubble diagram. At small redshifts, this is possible without assumptions on the cosmic inventory and provides a fundamental test of the cosmological principle. At higher redshift we check for the self-consistency of the ΛCDM model.\nMethods.At small redshifts, we use public supernovae (SNe) Ia data to determine the deceleration parameter q0 and the SN calibration on opposite hemispheres. For the complete data sets we fit and the SN calibration on opposite hemispheres.\nResults.A statistically significant anisotropy of the Hubble diagram at redshifts is discovered (>95%C.L.). While data from the North Galactic hemisphere favour the accelerated expansion of the Universe, data from the South Galactic hemisphere are not conclusive. The hemispheric asymmetry is maximal toward a direction close to the equatorial poles. The discrepancy between the equatorial North and South hemispheres shows up in the SN calibration. For the ΛCDM model fitted to all available SNe, we find the same asymmetry.\nConclusions.The alignment of discrepancies between hemispheric Hubble diagrams with the equatorial frame seems to point toward a systematic error in the SN search, observation, analysis or data reduction. We also find that our model independent test cannot exclude the case of the deceleration of the expansion at a statistically significant level.\nKey words: cosmology: observations / large-scale structure of Universe / supernovae: general\n© ESO, 2007", "label": "No"}
{"text": "The present study investigates hydrocarbon oxidation processes at Isis and Amon mud volcanoes (MV's), in the eastern Nile deep-sea fan. In the water column, molecular and carbon isotopic signatures of light hydrocarbons indicate that gases rapidly dissolve in seawater and are partially oxidized.|In the upper sediments, anaerobic oxidation of the light hydrocarbons takes place, as clearly shown by their molecular and isotopic composition. These processes lead to the presence of a distinct Sulfate-Hydrocarbon Interface at 120-145 cm and 2050 cm below the seafloor, for Isis and Amon MV's, respectively. In contrast to processes occurring in the water column, a clear preferential oxidation of methane, propane and n-butane over ethane and i-butane is observed in the anoxic sediments. Furthermore, for the first time, fractionation factors have been determined for the anaerobic oxidation of propane and butane, being respectively -4.80 parts per thousand and -0.7 parts per thousand for delta(13)C, and -43.3 parts per thousand for delta(2)H of propane. (C) 2009 Published by Elsevier Ltd.", "label": "No"}
{"text": "Dogs can eat cat food, but that is just not a good thing to eat regularly. The diet of cats needs a special bill of fayre which can be different from the one of the dogs. It is common for cat food to be composed of a higher proportion of protein and fat, which may not be favorable to dogs if their diet consists of a lot of these components.\nAlso, because of the difference in the diet, the diet for cats might not have the required nutrients that dogs need to stay in good health. Eating a small portion of cat food occasionally probably won’t be very detrimental, unless of course your dog gets more accustomed to this new diet.\nHowever, dogs should stick to a balanced diet formulated specifically for dogs. Never forget to ask your vet what kind of food suits your dog’s needs the most.\n- 1 Different Kinds of Dog and Cat Food:\n- 2 What If my Dog Accidentally Eats Cat Food?\n- 3 Can Cat Food Be Harmful to Dogs?\n- 4 What Foods Should Dogs Eat?\n- 5 Final Thoughts:\n- 6 FAQ’s:\n- 7 Related Posts:\nDifferent Kinds of Dog and Cat Food:\nFor dogs, you can choose between a completely different diet, some consisting of kibble, others from a portion of wet canned food and even raw or homemade diets. These specificities are provided in the form of various flavors and formulas intended for various life stages, sizes, and dietary limitations.\nJust like cat foods, cat foods come in two forms – dry kibble and wet canned varieties with different options available for different stages of feline life and some special dietary requirements.\nThe good choice is to find producers that provide healthy products and are recommended by the veterinary associations as well. Keeping that in mind, of course, talk to your vet every other time to figure out the appropriate food for your pet according to your pet’s needs.\nWhat If my Dog Accidentally Eats Cat Food?\nIf a dog obtains cat food by mistake it is not normally a cause for panic. If the pet suffers from vomiting and diarrhea, it may be a sign of a more serious condition, and the owner needs help to establish the diagnosis and treatment.\nHowever, while dog food has separate formulae from cat food this might not offer enough nutrients to the dogs in case they eat it. Unless your dog is eating a very small amount of cat food, it will probably be ok but if your dog eats a lot of cat food this could over the long term cause imbalances in the dog’s nutrition.\nIf your dog is seen to show symptoms of digestive upset or ingests large amounts of cat food, a quick visit to the vet might be necessary to get professional advice. They would be working with your dog, assessing his health needs and offering specialized dieting counseling.\nCan Cat Food Be Harmful to Dogs?\nA cat’s food is not harmful to dogs if given a small amount, but it’s not an ideal food diet for their overall physiology. Although doing so on an occasional basis might not be harmful, feeding dog cats food frequently may put it off balance.\nBecause the dietary requirements of cats are completely incomparable to those of dogs, the composition as well as the taste of cat food are tailored carefully. Dogs have been known to have different nutritional requirements than humans, therefore, my diet of cat food may not contain some of the required nutrients that dogs may need for their health to function well.\nBe sure that the dog’s diet plates a balanced and correct balance of what a dog might need. If you are worried about whether a dog could eat cat food or you see that he has consumed cat food by mistake then definitely consult your vet.\nWhat Foods Should Dogs Eat?\nDogs should have proper nutrition which is based on nutrients that are suitable for their health. This is generally the type of high-quality food that provides an adequate amount of protein, carbohydrates, fat and other vital vitamins and minerals.\nYou want to buy a portion of dog food that should take the age, size and dietary needs of the dog into view. Furthermore, veterinarian consultation is the prerequisite here to know the proper diet for your pet. Hence, it will greatly help.\nHumans can feed dogs cat food, but it’s not the best choice for a dog. Compared to dogs, cats have very specialized dietary needs. This means that the type of food you feed your cat might be lacking certain nutrients that are needed for the overall health of dogs. To keep it on track, stick to a balanced diet that is proven to be safe for folks.\nCan cat food make my dog sick?\nThough the occasional bite is not very likely to do harm, the frequent feeding of this cat food as a part of your dog’s diet may lead to undesirable conditions like an upset stomach, diarrhea and eventually pancreatitis which is caused by higher levels of fat.\nWhat if my dog loves the taste of cat food?\nWhen it comes to diet, cats usually have more meat taken into their diet and thus dogs might be attracted by this article. In order to make sure that your dog doesn’t eat cat food, you must control the access to the food or you can feed them in separate areas.\nAre there any benefits to dogs eating cat food?\nComplete nutritional requirements of cats are thus provided through different types of cat food while different types of dog food may not be sufficient for them. Among the safest ways is following a specific diet for dogs since it will help it to be well balanced.\nWhat should I do if my dog accidentally eats cat food?\nIf your dog appropriately consumes cat food and it is just a tiny amount, then it is nothing to get worried about. But if the dogs seem uneasy about the whole idea or show any symptoms of discomfort, then you can consult with your veterinarian to get proper advice.", "label": "No"}
{"text": "Main Article Content\nHerein, we present and discuss the result of 148 measurements of soil CO2 flux performed for the first time in Linosa island (Sicily Channel, Italy), a Plio-Pleistocene volcanic complex no longer active but still of interest owing to its location within a seismically active portion of the Sicily Channel rift system. The main purpose of this survey was to assess the occurrence of CO2 soil degassing, and compare flux estimations from this island with data of soil degassing from worldwide active volcanic as well as non-volcanic areas. To this aim soil CO2 fluxes were measured over a surface of about 4.2 km2 covering ~80% of the island. The soil CO2 degassing was observed to be mainly concentrated in the eastern part of the island likely due to volcano-tectonic lineaments, the presence of which is in good agreement with the known predominant regional faults system. Then, the collected data were interpreted using sequential Gaussian simulation that allowed estimating the total CO2 emissions of the island. Results show low levels of CO2 emissions from the soil of the island (~55 ton d-1) compared with CO2 emissions of currently active volcanic areas, such as Miyakejima (Japan) and Vulcano (Italy). Results from this study suggest that soil degassing in Linosa is mainly fed by superficial organic activity with a moderate contribution of a deep CO2 likely driven by NW-SE trending active tectonic structures in the eastern part of the island.\nNo Permission Required\nIstituto Nazionale di Geofisica e Vulcanologia applies the Creative Commons Attribution License (CCAL) to all works we publish.\nUnder the CCAL, authors retain ownership of the copyright for their article, but authors allow anyone to download, reuse, reprint, modify, distribute, so long as the original authors and source are cited. No permission is required from the authors or the publishers.", "label": "No"}
{"text": "(Invited) Elucidating the Origin of Resistive Switching in Ultrathin Hafnium Oxides through High Spatial Resolution Tools\nHafnium oxide thin films with different thicknesses and morphologies are analyzed using a Semiconductor Parameter Analyzer (SPA) connected to a Conductive Atomic Force Microscope (CAFM) working in controlled atmospheres (dry Nitrogen and a vacuum of 10-7 torr). Ramped Voltage Stresses have been performed at single locations of the samples to induce the formation of Conductive Filaments (CFs) - reach the dielectric breakdown (BD), or forming - . We analyze one-by-one the reversibility of those CFs, and we discern those locations where the BD could be recovered. Our experiments indicate that RS is only reachable at those filaments formed at the grain boundaries (GBs) of pseudo-amorphous and poly-crystalline samples (induced by thermal annealing), while the CFs induced at the nanocrystals or through the amorphous samples became irreversible (even using a current limitation). Kelvin Probe Force Microscope maps reveal that GBs are rich in defects, which correlates to larger leakage currents in (current maps) and lower BD voltages (forming, in IV curves). The lower BD voltages observed at the GBs (which, interestingly, coincide to those observed in MIM capacitors) may produce a less dramatic BD event, leading to narrower filaments easier to reoxidize. Moreover, the absolute value of the currents observed in LRS though a CF and a MIM structure are similar, indicating that RS in HfO2 stacks is a local phenomenon. This hypothesis is further supported by the fact that the currents through a CF in HRS and LRS can be fitted to the soft- and hard-BD equations. Finally we also show that, apart from creating/analyzing single CFs, the CAFM can also be used to perform statistical analyzes of the density, current and size of the CFs. In this case, two experiments are suitable to provide such information. The first consists of inducing the stresses in real capacitors, and scanning the surface of the insulator after etching the top electrode; and the second consists of collecting sequences of current maps at the same location of the sample using different voltages to observe a complete set-reset-set cycle. Since the maps cover larger areas and generate many filaments, this second test can be even combined with chemical analyses of lower spatial resolution.\nIn summary, CAFM experiments allow the correlation between nanoscale morphological features and electrical signals, and they can provide essential information to understand the origin of RS. In this work, CAFM studies experimentally in-situ proved, for the first time, that resistive switching in HfO2 stacks only takes place at the grain boundaries in polycrystalline samples due to an unusual high concentration of defects that minimize the violence of the BD event.", "label": "No"}
{"text": "Talk:In vivo experiment\nAnything from this Whitehurst quote worth adding?\nRuss Whitehurst on an APS Observer web page said: \"One explanation for the limited use of instructional practices based on cognitive science rests in the differences between classrooms and laboratories. In contrast to learning in laboratory settings, learning in classrooms typically involves content of greater complexity and scope, delivered and tested over much longer periods of time, with much greater variability in delivery, and with far more distraction and competition for student time and effort. Before principles of learning from cognitive science can be applied to classroom instruction, we need to understand if the principles generalize beyond well controlled laboratory settings to the complex cognitive and social conditions of the classroom.\"\nShould the idea be called \"in situ\" rather than \"in vivo\"?\nHere's an email dialog, started by Jacqueline Bourdeau, around the question of whether we should use \"in situ experiment\" rather than \"in vivo experiment\". Perhaps some of this dialog should get into the article ...\nThanks for your great question! Indeed there is possibility for confusion. It appears, though, that all the definitions of /in vivo/ that people found are inclusive of field trials and, while they allow for it, they don't require dissection of students! :)\n1) The /in vivo/ definition Vincent found explicitly mentions \"clinical trials\" -- which are field-based randomized controlled experiments in medicine. \"Animal testing <http://en.wikipedia.org/wiki/Animal_testing> and clinical trials <http://en.wikipedia.org/wiki/Clinical_trials> are two forms of /in vivo/ research.\"\n2) The /in vivo/ definition David found explicitly includes \"environment\": \"/in vivo/ experimentation allowed testing to occur in the originate organism or environment.\"\n3) And even your definition includes \"natural setting\": \"in vivo = (of a biological process) occurring or made to occur within a living organism or natural setting.\"\nOur definition of /in vivo/ experimentation is \"principle-testing experiments run in the context of academic courses\". The \"field\" \"environment\" or \"natural setting\" is the place in which course work is done, whether that is the classroom, computer lab, study hall, dorm room, home, etc.\nI can see an argument for \"in situ experiment\" being a good alternative name, but it doesn't seem as though \"in vivo\" is being incorrectly used.\nLike the photographer of animals in the wild, we have an observational tool or instrument that allows us to capture an aspect of the phenomenon, though, like the photographer, certainly not all of it. Our key observational instrument is not the camera, but it is educational technology tools that log student interactions.\nThe broader substantive point is our effort to add awareness to /in vivo/ experimentation to the array of methodologies in the learning and educational sciences. /In vivo/ experimentation is different from (not necessarily better than) other methodologies in the learning and educational sciences including 1) design-based research, as you mentioned, which doesn't have control conditions, 2) randomized field trials, which don't test a principle, but a policy or curriculum, and 3) lab experiments, which are not run in a natural setting. I have emphasized weakness, but all of these methodologies have strengths and should be applied at the right time for the right purpose. (I have participated in all four myself.)\nOn 10/21/10 10:10 AM, Jacqueline Bourdeau wrote:\n> In vivo experiment: > - 'experiment' includes control and manipulation > - so what does in-vivo mean in this expression? if taken literally, it would mean controlling and manipulating the brain; if analogically, then what? manipulating cognitive-emotive functions? In that case, shouldn't we rather think of virtual frog dissection? Then we should use Noboru's virtual student! > if what we mean is controlling and manipulating cognitive-emotive functions in a real setting, then I consider that in situ experiment is a correct wording. Or maybe situated experiment. > I like Design-Based research, but I understand that it is different, since DBR means to test and vary the design itself, not to control and experiment on students. > Jacqueline > > *From:* Vincent Aleven <mailto:firstname.lastname@example.org> > *Sent:* Wednesday, October 20, 2010 10:59 PM > *To:* klahr <mailto:email@example.com> > *Cc:* Geoff Gordon <mailto:firstname.lastname@example.org> ; PSLC-EC <mailto:email@example.com> ; firstname.lastname@example.org <mailto:email@example.com> > *Subject:* Re: in vivo experiments? > > The wikipedia definition is confusing. In situ means exactly in the place where the phenomenon occurs. \"In the wild.\" > > This seems exactly aligned with what we mean by \"in vivo experiments.\" But then it also goes on to say that \"in situ\" means that an organ may be isolated for which the donor is sacrificed ???? > > I have trouble reconciling these definitions. It all depends on context I am sure. > > > Wikipedia also says: > > /*In vivo*/ (Latin <http://en.wikipedia.org/wiki/Latin_language> for \"within the living\") is experimentation using a whole, living organism <http://en.wikipedia.org/wiki/Organism> as opposed to a partial <http://en.wikipedia.org/wiki/Biopsy> or dead organism, or an /in vitro <http://en.wikipedia.org/wiki/In_vitro>/ controlled environment. Animal testing <http://en.wikipedia.org/wiki/Animal_testing> and clinical trials <http://en.wikipedia.org/wiki/Clinical_trials> are two forms of /in vivo/ research. /In vivo/ testing is often employed over /in vitro/ because it is better suited for observing the overall effects of an experiment on a living subject. This is often described by the maxim /in vivo veritas/.^ <http://en.wikipedia.org/wiki/In_vivo#cite_note-0> > > > So that sounds reasonably well-aligned with what we mean by an in vivo experiment (though the first definition of in situ captures it even better - though it is contradicted by the second definition). > > Clearly, under this definition, in vivo does not necessarily mean IN the living organism. > > Vincent > > PS Anybody wants to make the case that \"in situ\" really is analogous to \"pull out experiments?\" :-) > > > > On 10/20/10 10:32 PM, klahr wrote: >> >> Two responses: First fm wiki: >> In biology <http://en.wikipedia.org/wiki/Biology>, /in situ/ means to examine the phenomenon exactly in place where it occurs (i.e. without moving it to some special medium). >> In the case of observations or photographs of living animals, it means that the organism was observed (and photographed) in the wild, exactly as it was found and exactly where it was found. The organism had not been moved to another (perhaps more convenient) location such as an aquarium. >> This phrase /in situ/ when used in laboratory science such as cell science can mean something intermediate between /in vivo <http://en.wikipedia.org/wiki/In_vivo>/ and /in vitro <http://en.wikipedia.org/wiki/In_vitro>/. For example, examining a cell <http://en.wikipedia.org/wiki/cell_%28biology%29> within a whole organ <http://en.wikipedia.org/wiki/Organ_%28anatomy%29> intact and under perfusion <http://en.wikipedia.org/wiki/Perfusion> may be /in situ/ investigation. This would not be/in vivo/ as the donor is sacrificed before experimentation, but it would not be the same as working with the cell alone (a common scenario for /in vitro/ experiments). >> /In vitro/ was among the first attempts to qualitatively and quantitatively analyze natural occurrences in the lab. Eventually, the limitation of /in vitro/ experimentation was that they were not conducted in natural environments. To compensate for this problem, /in vivo/ experimentation allowed testing to occur in the originate organism or environment. To bridge the dichotomy of benefits associated with both methodologies, /in situ/ experimentation allowed the controlled aspects of /in vitro/ to become coalesced with the natural environmental compositions of /in vivo/ experimentation. >> >> Second: I know that Kevin Dunbar popularized the term in cognitive science when he studied scientific thinking by observing the reasoning processes used by researchers in real molecular biology labs, rather than in the psychology lab. He was just applying the analogy between /in vitro/ and /in vivo/ commonly used in the biological sciences to his work (Dunbar, K. (1995). How scientists really reason: Scientific reasoning in real-world laboratories. In R.J. Sternberg, & J. Davidson (Eds.). /Mechanisms of insight/. Cambridge MA: MIT press. pp 365-395). Ken Koedinger has also used the analogy to emphasize the difference between \"in vitro\" (/aka/ \"laboratory studies\") that are so common in cognitive psychology, with the kind of \"in vivo\" studies done by many in the PSLC in which the experimental manipulations are embedded in real classrooms, by real teachers (or teaching agents), on real students, who are really trying to lean something, rather than participating in experiments. >> >> At least thats my take on the issue. If I've mis-characterized Ken's view, I'm sure he'll join the discussion. >> >> -David >> >> >> On Oct 20, 2010, at 7:14 PM, Geoff Gordon wrote: >> >>> An interesting question. My thought is that learning does occur within the student -- we just don't try to discover it with scalpels, but measure it at least somewhat non-invasively. >>> >>> -Geoff. >>> >>> >>> On Oct 20, 2010, at 5:19 PM, Vincent Aleven wrote: >>> >>>> It seems to me this query should be addressed by the EC as a whole ... ;-) >>>> >>>> >>>> >>>> -------- Original Message -------- >>>> Subject: >>>> in vivo experiments? >>>> Date: >>>> Wed, 20 Oct 2010 16:37:15 -0400 >>>> From: >>>> Jacqueline Bourdeau <firstname.lastname@example.org <mailto:email@example.com>> >>>> To: >>>> Vincent Aleven <firstname.lastname@example.org <mailto:email@example.com>> >>>> >>>> >>>> Dear Vincent, >>>> I recently met the 'in-vivo experiments' in 2 of your publications, 2007 (Koedinger, Kenneth; Aleven, Vincent; Baker, Ryan. In vivo experiments on whether tutoring meta-cognition yields robust learning. 12th Biennial Conference for Research on Learning and Instruction (EARLI). Budapest, Hungary, August, 2007. 2007) >>>> >>>> Are you still using this expression? >>>> >>>> To my knowledge, in vivo = (of a biological process) occurring or made to occur within a living organism or natural setting. >>>> But we do not (yet) use scalpels with students! >>>> >>>> Did you mean in situ? >>>> = situated in the original, natural, or existing place or position >>>> In situ is used to distinguish from a lab experiment; it means in classroom or any other natural setting >>>> >>>> I would very much like to have your feedback on this. I should say that I am very curious! >>>> Jacqueline", "label": "No"}
{"text": "$2,500 prized parrot stolen from Windsor pet store\nCorbret's pets suspects someone stuffed the orange winged Amazon in their coat and left\nA $2,500 prized parrot has been stolen from a Windsor pet store.\nFour-month-old Coco, an orange winged Amazon parrot, was taken from Corbret's Pets sometime Wednesday evening.\nStore manager Cory Drouillard the store was busy at the time of the bird’s disappearance.\nThe bird, native to south America, is worth thousands because it's been hand fed by humans since it hatched.\n“If you wanted to grab the bird and put it in your coat, the bird wouldn’t squawk or anything you could because it’s used to human comfort,” Drouillard said.\nStaff suspects that's exactly what happened; that someone stuffed the bird in their coat pocket and left the store.\nCoco speaks, often squawking the phrases \"pretty bird\" and \"kiss me.\"\nCoco responds to its name and knows approximately 25 words but has the ability to learn more.\nThe bird needs to eat fruits, nuts and seeds and be housed in the proper temperature.\nDrouillard asked the public to be on the look out. He said people with new pets usually like to \"show them off.\"\nWindsor police have been notified and are investigating. Corbret's Pets are offering an award, the amount to be discussed upon the return of the bird.\n\"We would like our baby bird back,\" Drouillard said. \"We just want our bird back and problem solved.\"", "label": "No"}
{"text": "Science Communication in Theory and Practice\nResearch museums are places of education, teaching and knowledge transfer, as well as public scientific discourse. In what way can a natural history research museum make this a stimulating task and do justice to its role as a public discussion forum at the interface of science, politics and society? Science Programme 4 is concerned with the question how interaction between members of the scientific community and other stakeholders works, how interaction between stakeholders shapes ideas about nature and thus the relationship between human beings, nature and culture. Finally, what was the particular role research museums had in the process in the past, what is it now and what will it be in the future?", "label": "No"}
{"text": "OR WAIT null SECS\n© 2021 MJH Life Sciences and Medical Economics. All rights reserved.\n© 2021 MJH Life Sciences™ and Medical Economics. All rights reserved.\nDecember 01, 2021\nPreHevbrio is the only 3-antigen vaccine for Hepatitis B approved for adults\nNovember 23, 2021\nIs more testing the answer to a worsening drug crisis?\nNovember 17, 2021\nThe \"Cures 2.0\" bill, if signed into law, would expand medical research, aid development of new therapies and expand telehealth.\nNovember 16, 2021\nThe product is the first interchangeable insulin biosimilar approved by the FDA.\nNovember 15, 2021\nHealthcare staffing shortages exacerbated by the COVID-19 pandemic have intensified an already serious problem in healthcare: clinician burnout.\nI do not use annual visits for disease management but rather health promotion.\nNovember 11, 2021\nUntil now, measures to prevent cardiovascular diseases have focused almost entirely on individual behavioral and metabolic risk factors.\nNovember 01, 2021\nHow medical practices can create effective vaccination programs for the months ahead\nOctober 13, 2021\nAs we move beyond COVID-19, The healthcare industry is just beginning to uncover the impact of delayed cancer screenings and care on oncology outcomes.\nSeptember 22, 2021\nProper implementation of remote patient monitoring can be beneficial for practices and patients.", "label": "No"}
{"text": "Feb 13, 2019. In moderation, ginger is one of the best foods for acid reflux. or sautéed (but not fried!), and you must remove the skin, which is high in fat. because of its high water content, and is a good choice if you have acid reflux.\n29.03.2019 · How to Prevent Acid Reflux During Pregnancy. Recurring bouts of acid reflux (or heartburn) during pregnancy is very common because the higher levels of estrogen and progesterone cause the lower esophageal sphincter to weaken and allow.\nIf you’re interested in adding aloe vera juice to your acid reflux treatment regimen, you should talk with your doctor. They can help you decide whether this is the best treatment for you.\nOct 10, 2013. Over 15 million Americans suffer from gastroesophageal reflux disease, or GERD. While many. medications, a new technology can help relieve the burn for good. “I would get a lot of chest pain and I would throw up a lot.”.\nDec 25, 2016. Acid reflux symptoms: How to get rid of heartburn NATURALLY. Brits, but hundreds find endless good food and drinks at Christmas make their.\n1. What is Acid Reflux? Acid reflux is a painful condition that affects millions of people all over the world. It is caused when your stomachs digestive acids make their way up into the esophagus.\nIf so, there are ways you can help treat GERD and its symptoms. Read on to find out the role cannabis plays in treating GERD and its symptoms. However, more research must be conducted to better understand the role of the body's ECS.\nCandida Krusei Uptodate Fungal Infection Of The Nasal Cavity with Tsa Candidate Dashboard Notification and Another Name For Candida Albicans are fungal infection due to any types of Candida. When it affects the vagina, it is commonly called a yeast infection.\nJul 16, 2018. Angelucci finally was able to quit Prilosec (omeprazole) — one of the most popular over-the-counter (OTC) drugs for acid reflux — for good 8.\n22.11.2002 · acid reflux : 41 messages in this subject. I pass on to all of you with the severe gerds and treatment with many of the ppi prescriptions, I have had nearly all of them with very little effect and after several yrs of these treatments I acquired nearly fatal c.diff infection.\nSep 25, 2018. Gastroesophageal reflux disease (GERD) is a condition where acid in the stomach. If you find this is the case for you, try to eat at least three hours before. Losing even a small amount of weight can make a difference in the.\n“The sooner we start an acid reflux diet and healthier lifestyle, the better,”. Acid reflux, the flow of stomach acid back into the esophagus, can become a serious.\nCant Get Rid Of Yeast Infection All Signs And Symptoms Of A Yeast Infection with Home Relief Yeast Infection and Yeast Infection Treatment In Pregnancy Cdc are fungal infection due to any types of Candida. When it affects the vagina, it is commonly called a yeast infection.\nIf you are suffering from acid reflux disease or any number of other digestive disorders (think. how you can eliminate your digestive problems by finding the root cause, treating. Why Medications for Heartburn Can Do More Harm Than Good.\nCommon Causes of Acid Reflux (Not What You Think) Intuitively, you’d be led to believe that if acid is coming up through the esophagus, it must mean you have high stomach acid –.\nDec 22, 2018. Here are 7 ways to avoid acid reflux while drinking coffee. The natural acid also contains powerful antioxidants that do the body good and made. treated to remove organic acids is objectionable to you, a dark roast coffee.\nHe discusses what acid reflux is, how to treat it without drugs, and the. Acid Is Good For You, “When we carefully test people over age forty who're. Our healthcare system spends an estimated $3.8 billion every year treating these infections.\nIf you have acid reflux, particularly if you have “airway reflux” or “silent reflux,” you should never drink these acid bombs. BTW, people with airway reflux have hoarseness, chronic cough, trouble with food getting stuck, choking episodes, shortness of breath, asthma, and sinusitis.\nTechnically, acid reflux is also called gastroesophageal reflux disease (GERD), gastro-oesophageal reflux disease (GORD) or gastric reflux disease.\nDoctors do not recommend drinking milk to reduce heartburn, as it has been proven. are generally not a good way to ensure a peaceful night for heartburn sufferers. and beverages you eat and drink can aggravate your heartburn symptoms, Proton pump inhibitors (PPIs), like Prilosec OTC, more effectively inhibit acid.\nFeb 12, 2016. If you suffer from acid reflux, take inventory of your life and determine. There are also many good enzyme supplements available; I recommend VeganZyme™. pressure or if you are on a sodium-restricted diet it's best to get advice first. and are not intended to replace the advice of your treating doctor.\nFed Tube Gerd Acid reflux occurs when acidic stomach contents flow back into the esophagus, the swallowing tube that leads from the back of the throat to the stomach. Pauses in breathing (apnea) or snoring when sleeping; Feeding difficulty (spitting up). It happens when stomach contents flow back up (reflux) into the food pipe ( esophagus). have GERD\nTechnically, acid reflux is when the acid flows backwards into your esophagus, heartburn is the symptom you get from it and GERD is the name for it if it lasts a long time.\nHELP!!!! Ever since I’ve gained weight, I have been dealing with acid reflux. I’ve been taking the off brand version of prilocec (please excuse my spelling lol). 90 percent of the time I’m good, but then there’s nights like tonight….\nCan Stevia Cause Acid Reflux – Cures for gerd – Try this stevia product:. Can this be the cause of the damage in my stomach?. Ask Dr. Hull Alternative Health Web Forum. acid reflux diet: Learn about acid.\nExcessive stomach acid can be uncomfortable to live with, and while in many cases it is a minor nuisance, it can lead to serious health problems when not treated.\nLearn about gastroesophageal reflux disease (GERD, acid reflux, heartburn) symptoms like heartburn, chest pain, regurgitation, and nausea. Diet, causes, diagnosis, treatment and.\nMar 15, 2019. Acid reflux or the weakness of the LES can occur due to many reasons, including: Increased. Treating acid reflux in children naturally is one of the best options you have. Natural or. Is milk good for acid reflux? Can my.\nFor some people with mild GERD symptoms, lifestyle changes alone may. In addition to avoiding dietary triggers, our doctors may recommend several lifestyle changes you can make to alleviate GERD symptoms:. Experts at NYU Langone's Tobacco Cessation Programs can advise you on how to quit smoking for good.\nSep 2, 2014. I'm currently trying to remove all grains and dairy from my diet and that also. The Paleo Solution makes a good argument about how milk and grains are an. Play detective and you will find out what is causing the acid reflux.\nFeb 5, 2018. You can learn how to make your own homemade apple cider vinegar from. Most folks down a spoonful after a meal to get rid of acid reflux, with yellow. Maybe our ancestors were on to something other than just good flavor.\nThe Scoop on Acid Reflux Remedies through the eyes of a friendly Nurse. Fast, instant and quick acid reflux remedies, natural home remedies for acid reflux, indigestion and heartburn can be as close as your kitchen cabinet.\nDo you Suffer from constant Gas and Bloating? Here are the 21 Tips on How to Get Rid of Bloating Fast – even if you’re already on a healthy diet.\nAcid reflux is caused by digestive juices creeping up from the stomach back into the esophagus. Click to learn how an acid reflux diet can help symptoms.\nOverview. Believe or not, acid reflux is such a common problem that almost all people in the world have experienced it at least once. If you have never had it, then you belong to the very minority that should get a Guinness world record.", "label": "No"}
{"text": "In the Adult Clown Fish Costume\nyou’ll be transformed into this colorful orange fish. If you’ve seen and loved this beautiful orange fish with white stripes in aquariums then here is your chance to become that fish! Swim amongst the sea turtles and coral reefs in this clown fish costume. This beautiful orange fish mask makes a quick and easy Halloween costume!\nShipping (Processing Time + Transit Time): Processing time is approximately 1-2 business days to leave the warehouse plus transit time.", "label": "No"}
{"text": "A knockout has two roles, that is, the role of a stripper of a hole punching punch and the role of ejecting the product that has entered inside the die. Normally, a knockout is prepared with the same shape as that of the product.\nAs shown in Fig. 1, a knockout is assembled inside the die. A compound die has the inverted placement structure in which the die for outer shape punching is the top die (goes up and down along with the slide of the press machine) and the punch for outer shape punching is the bottom die (fixed on the bolster plate side of the press machine). A knockout is a characteristic part of this structure.\nAs shown in Fig. 2, the surface of the knockout is either made level with the die surface or is made to project slightly beyond it. The amount of projection is about 0.5 mm to 1.0 mm. Contrary to common assumption, it is very rare that its surface is made level with the surface of the die.\nWhen the knockout has moved by the maximum amount inside the die, as shown in Fig. 3(a), care should be taken so that the cutting edge of the die does not get separated, or the stepped part of the hole punching punch does not hit against the reverse side of the knockout.\nAs shown in Fig. 3(b), when the knockout gets separated from the cutting edge of the die, in some rare cases, the knockout can become immovable because it has got stuck to the underside of the cutting edge of the die, and hence causing the die to break.\nIn addition, the interference between the stepped part of the hole punching punch and the hole of the knockout can lead to breakage of the knockout or of the punch.\nThe knockout is always in contact with the blank material. The material is often coated with cutting oil, and due to this oil the material adheres closely to the knockout, and even after the product is ejected from the die it sticks to the surface of the knockout, leading to the problem of double product punching (the problem of punching the material again with a product remaining stuck on the knockout), which can break the die. This phenomenon is a kind of trouble that cannot be prevented even when the operator is being cautious. It is preferable to take countermeasures for this in the structure of the die.\nAs shown in Fig. 1, adhesion of the material to the knockout is prevented by providing a kicker pin in the knockout. When only one kicker pin is provided, it is positioned at the center of gravity, and when several kicker pins are provided, they are positioned considering the balance among them.\nThe amount of projection of the kicker pin is about 0.5 mm to 1.0 mm. Even when the product is collected using an air blow, since the form in which the product is separated from the knockout is the same, the direction of flying of the product becomes stable. In the case of a kicker pin with a large amount of projection, the tip of the pin can get caught in a hole in the product when the product is flying away thereby leading to an accident. Therefore, it is preferable to use a smaller amount of projection.\nIt is not good to make the outer shape of the knockout become completely identical to the shape of the die. The metal shreds, etc., that are generated during the punching operation get inside the gap between the knockout and the die, thereby causing fusing between them. This may also cause the movement of the knockout to become not smooth.\nAs shown in Fig. 2, the guiding is done by a surface with a stable shape (linear parts, etc.), detailed shape portions or corners are provided with escapes by providing R or C chamfering thereby reducing the parts that can cause problems.\nIn the escapes for the rounded (R) portions, it is better that the projecting R portions are not escaped by making the rounding R shape small, but by C surfaces. The recess R portions are escaped by providing corners or small R. It is also good to provide escapes in the middle of long straight line portions.", "label": "No"}
{"text": "Saffron oil for a radiant complexion and even skin tone. The benefits of saffron oil include reducing acne and wrinkles, hair care and skin lightening. This unique oils and herbs is formulated to help skin look young and healthy. Pure saffron helps lighten the complexion. This unique oils and herbs is formulated to keep skin looking young and healthy.\nSaffron is a spice derived from the flower, which is collected and dried for use primarily as a flavoring and coloring agent in food. Saffron has countless benefits, is rich in nutrients and is full of health and skin benefits. The aroma of saffron oil releases serotonin into the body and helps combat depression and anxiety. It also promotes good sleep and treats the condition of insomnia.\nSaffron Essential Oil in Soap\nSaffron essential oil is the oil extracted from the saffron herb, making it a popular medicine with an astringent quality that can help purify skin that suffers from acne. With its amazing antibacterial and anti-inflammatory qualities, saffron is an ideal natural ingredient for treating acne and pimples.\nSaffron Essential Oil in lotion\nIt is excellent in reducing pigmentation, brown spots, and other blemishes of the skin.\nFrequently asked questions about Saffron Essential Oil\nWhat is the INCI of Saffron Essential Oil ?", "label": "No"}
{"text": "Spatial variation in acid and some heavy metal composition of rainwater harvesting in the oil-producing region of Nigeria\nAbstractThe study adopted the experimental research design and field survey of the oil-producing region of Nigeria for the past 10 years. A total of 100 sterilized rain gauges were randomly distributed on the basis of 50 each to the eastern and western division of the oil company operating in the region. The rainwater samples harvested through this process were transferred into sterilized plastic containers and kept in coolers and taken immediately to the laboratory for analysis soon after every rain event. The rainwater samples were analysed in the laboratory with the most appropriate techniques. The physicochemical characteristics of rainwater harvested were subjected to paired t test and 3-year moving average statistical analysis. The following are the results: There is widespread acid rain in the region, this is evident from pH values that span 4.98–5.15 and 5.06 mean values. The result also revealed that acid rain (pH) varied significantly (P > 0.05), and it decreases with increasing distance from gas flare sites throughout the period of study. Other physicochemical characteristics of rainwater resources conform to safe limit with the exception of turbidity, TSS, Pb and NO 3, which is also significant at P > 0.05 with increasing distance from the gas flare sites, as such they decreases with increasing distance. This certainly has serious environmental effects on the human and other species, soil, water and vegetation resources and calls for the extinction of gas flaring, in this region. Sources of water that are acidified should be periodically limed to reduce the acid concentration in such water. Copyright Springer Science+Business Media B.V. 2010\nDownload InfoIf you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.\nBibliographic InfoArticle provided by International Society for the Prevention and Mitigation of Natural Hazards in its journal Natural Hazards.\nVolume (Year): 55 (2010)\nIssue (Month): 2 (November)\nContact details of provider:\nWeb page: http://www.springer.com/economics/journal/11069\nYou can help add them by filling out this form.\nCitEc Project, subscribe to its RSS feed for this item.\n- Ojimba, Thankgod Peter, 1. \"Socio-Demographic Factors As Determinants Of Poverty In Crude Oil Polluted Crop Farms In Rivers State, Nigeria,\" International Journal of Food and Agricultural Economics (IJFAEC), Niğde University, Faculty of Economics and Administrative Sciences, vol. 1.\nFor technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Guenther Eichhorn) or (Christopher F Baum).\nIf references are entirely missing, you can add them using this form.", "label": "No"}
{"text": "Lybrate.com has an excellent community of Radiologists in India. You will find Radiologists with more than 27 years of experience on Lybrate.com. You can find Radiologists online in Delhi and from across India. View the profile of medical specialists and their reviews from other patients to make an informed decision.\nBook Clinic Appointment\nDiagnostic X- Ray\nAngiography Radial Approach\nBone Densitometry Procedure\nInterventional Diagnostic Procedures\nUterine Artery Embolization\nSubmit a review for Dr. Yogendera MittalYour feedback matters!\nI am an advocate and have got sitting job for long hours and walking job too. I am suffer from slip disc. Any treatment?\nI am a 38 year old married lady with 2 kids. I have herniated disc of l5 s1 with mild detention as detected in mri. What is the treatment? I am really scared. Is it dangerous?\nHello doctor plzz say me is surgery essential for Diffuse annular disc bulge seen at l4 and l5 level causing indentation over thecal sac with bilateral recess narrowing and significant nerve decompression.\n1. Eat calcium-rich foods\nIn addition to dairy products, choose fish with bones such as salmon, sardines or whitebait. For additional benefits, serve them with a side of dark leafy green vegetables or broccoli. Almonds, dried figs, fortified tofu and soy milk are also calcium-rich choices, says registered dietitian laura jeffers, med, rd, ld.\n2. Take calcium supplements\nThe u. S. Recommended daily allowance for calcium is 1, 000 mg a day during your 20s, 30s and 40s. But your need rises as you age. Check with your doctor before starting supplements to find out what amount is right for you. For example, after menopause, most women need 1000 to 1, 500 mg a day unless they take hormone therapy. Your body only absorbs 500 mg of calcium at a time, Ms. Jeffers notes, so spread your consumption out over the course of the day.\n3. Add d to your day\nTo help absorb calcium, most adults need 1, 000 to 2, 000 iu of vitamin d daily, combined calcium-vitamin d pills usually do not meet this requirement. And most of us who live north of atlanta do not get enough vitamin d the old-fashioned way — from the sun. Taking a vitamin d supplement will ensure you meet your daily needs.\n4. Start weight-bearing exercises\nTo boost your bone strength, try exercise that “loads” or compresses your bones, says exercise physiologist heather nettle, ma. “running, jogging, high-impact aerobics, repetitive stair climbing, dancing, tennis and basketball are best for building bones. But if you have osteopenia, osteoporosis or arthritis, try walking or using an elliptical or other machine,” she says. Be sure to clear any exercise plans with your doctor first.\n5. Don’t smoke, and don’t drink excessively\nBad news for bad habits: loss of bone mineral density is associated with tobacco use and excessive alcohol consumption, Dr. Sikon says. If you smoke, look into a program to help you quit. If you drink, stick to no more than one libation a day, she advises.\n6. Get your bone mineral density tested\nDoctors can get a quick and painless “snapshot” of bone health using a simple x-ray test called dxa. This test measures bone mineral density and helps determine risks of osteoporosis and fracture. Dr. Sikon recommends testing for women within two years of menopause. Earlier tests are recommended for men and women with certain diseases and for those taking medications that increase risk, such as long-term steroid therapy.\nPerimenopausal women may consider hormone therapy to increase waning estrogen levels, which are linked to bone loss. And women and men diagnosed with osteopenia or osteoporosis can take various medications to prevent dangerous hip and spine fractures.\nBreast Cancer Prevention:\nAnything that increases your chance of developing cancer is called a cancer risk factor; anything that decreases your chance of developing cancer is called a cancer protective factor.\nSome risk factors for cancer can be avoided, but many cannot. For example, both smoking and inheriting certain genes are risk factors for some types of cancer, but only smoking can be avoided. Regular exercise and a healthy diet may be protective factors for some types of cancer. Avoiding risk factors and increasing protective factors may lower your risk but it does not mean that you will not get cancer. Different ways to prevent cancer are being studied, including:\nChanging lifestyle or eating habits. Avoiding things known to cause cancer. Taking medicine to treat a precancerous condition or to keep cancer from starting.\nGeneral information about breast cancer:\nBreast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. Breast cancer is the second most common type of cancer in india\nBreast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast.\nThe breast is made up of lobes and ducts. Each breast has 15 to 20 sections called lobes, which have many smaller sections called lobules. Lobules end in dozens of tiny bulbs that can make milk. The lobes, lobules, and bulbs are linked by thin tubes called ducts.\nEnlarge Drawing of female breast anatomy showing the lymph nodes, nipple, areola, chest wall, ribs, muscle, fatty tissue, lobe, ducts, and lobules.\nAnatomy of the female breast. The nipple and areola are shown on the outside of the breast. The lymph nodes, lobes, lobules, ducts, and other parts of the inside of the breast are also shown.\nEach breast also has blood vessels and lymph vessels. The lymph vessels carry an almost colorless fluid called lymph. Lymph vessels lead to organs called lymph nodes. Lymph nodes are small bean-shaped structures that are found throughout the body. They filter lymph and store white blood cells that help fight infection and disease. Clusters of lymph nodes are found near the breast in the axilla (under the arm), above the collarbone, and in the chest.\nAvoiding risk factors and increasing protective factors may help prevent cancer. The following are risk factors for breast cancer:\nOlder agea personal history of breast cancer or benign (noncancer) breast diseasea family history of breast cancerinherited gene changesdense breasts\nExposure of breast tissue to estrogen made in the bodytaking hormone therapy for symptoms of menopause radiation therapy\nThe following are protective factors for breast cancer:\nLess exposure of breast tissue to estrogen made by the bodytaking estrogen-only hormone therapy after hysterectomy,\nEstrogen-only hormone therapy after hysterectomyselective estrogen receptor modulatorsaromatase inhibitors and inactivators\nRisk-reducing mastectomy ovarian ablationgetting enough exercise\nIt is not clear whether the following affect the risk of breast cancer:\nFactors include smoking, being overweight, and not getting enough exercise. Increasing protective factors such as quitting smoking and exercising may also help prevent some cancers. Talk to your doctor or other health care professional about how you might lower your risk\nOlder age is the main risk factor for most cancers. The chance of getting cancer increases as you get older.\nA personal history of breast cancer or benign (noncancer) breast disease\nWomen with any of the following have an increased risk of breast cancer:\nA personal history of invasive breast cancer, ductal carcinoma in situ (dcis), or lobular carcinoma in situ (lcis). A personal history of benign (noncancer) breast disease.\nA family history of breast cancer\nWomen with a family history of breast cancer in a first-degree relative (mother, sister, or daughter) have an increased risk of breast cancer.\nInherited gene changes:\nWomen who have inherited changes in the brca1 and brca2 genes or in certain other genes have a higher risk of breast cancer, ovarian cancer, and maybe colon cancer. The risk of breast cancer caused by inherited gene changes depends on the type of gene mutation, family history of cancer, and other factors.\nMen who have inherited certain changes in the brca2 gene have a higher risk of breast, prostate, and pancreatic cancers, and lymphoma.\nHaving breast tissue that is dense on a mammogram is a factor in breast cancer risk. The level of risk depends on how dense the breast tissue is. Women with very dense breasts have a higher risk of breast cancer than women with low breast density.\nIncreased breast density is often an inherited trait, but it may also occur in women who have not had children, have a first pregnancy late in life, take postmenopausal hormones, or drink alcohol.\nExposure of breast tissue to estrogen made in the body\nEstrogen is a hormone made by the body. It helps the body develop and maintain female sex characteristics. Being exposed to estrogen over a long time may increase the risk of breast cancer. Estrogen levels are highest during the years a woman is menstruating.\nA woman's exposure to estrogen is increased in the following ways:\nEarly menstruation: beginning to have menstrual periods at age 11 or younger increases the number of years the breast tissue is exposed to estrogen. Starting menopause at a later age: the more years a woman menstruates, the longer her breast tissue is exposed to estrogen. Older age at first birth or never having given birth: because estrogen levels are lower during pregnancy, breast tissue is exposed to more estrogen in women who become pregnant for the first time after age 35 or who never become pregnant.\nTaking hormone therapy for symptoms of menopause:\nHormones, such as estrogen and progesterone, can be made into a pill form in a laboratory. Estrogen, progestin, or both may be given to replace the estrogen no longer made by the ovaries in postmenopausal women or women who have had their ovaries removed. This is called hormone replacement therapy (hrt) or hormone therapy (ht). Combination hrt/ht is estrogen combined with progestin. This type of hrt/ht increases the risk of breast cancer. Studies show that when women stop taking estrogen combined with progestin, the risk of breast cancer decreases.\nRadiation therapy to the breast or chest:\nRadiation therapy to the chest for the treatment of cancer increases the risk of breast cancer, starting 10 years after treatment. The risk of breast cancer depends on the dose of radiation and the age at which it is given. The risk is highest if radiation treatment was used during puberty, when breasts are forming.\nRadiation therapy to treat cancer in one breast does not appear to increase the risk of cancer in the other breast.\nFor women who have inherited changes in the brca1 and brca2 genes, exposure to radiation, such as that from chest x-rays, may further increase the risk of breast cancer, especially in women who were x-rayed before 20 years of age.\nObesity increases the risk of breast cancer, especially in postmenopausal women who have not used hormone replacement therapy.\nDrinking alcohol increases the risk of breast cancer. The level of risk rises as the amount of alcohol consumed rises.\nThe following are protective factors for breast cancer:\nLess exposure of breast tissue to estrogen made by the body\nDecreasing the length of time a woman's breast tissue is exposed to estrogen may help prevent breast cancer. Exposure to estrogen is reduced in the following ways:\nEarly pregnancy: estrogen levels are lower during pregnancy. Women who have a full-term pregnancy before age 20 have a lower risk of breast cancer than women who have not had children or who give birth to their first child after age 35. Breast-feeding: estrogen levels may remain lower while a woman is breast-feeding. Women who breastfed have a lower risk of breast cancer than women who have had children but did not breastfeed.\nTaking estrogen-only hormone therapy after hysterectomy, selective estrogen receptor modulators, or aromatase inhibitors and inactivators\nEstrogen-only hormone therapy after hysterectomy\nHormone therapy with estrogen only may be given to women who have had a hysterectomy. In these women, estrogen-only therapy after menopause may decrease the risk of breast cancer. There is an increased risk of stroke and heart and blood vessel disease in postmenopausal women who take estrogen after a hysterectomy.\nSelective estrogen receptor modulators:\nTamoxifen and raloxifene belong to the family of drugs called selective estrogen receptor modulators (serms). Serms act like estrogen on some tissues in the body, but block the effect of estrogen on other tissues.\nTreatment with tamoxifen lowers the risk of estrogen receptor-positive (er-positive) breast cancer and ductal carcinoma in situ in premenopausal and postmenopausal women at high risk. Treatment with raloxifene also lowers the risk of breast cancer in postmenopausal women. With either drug, the reduced risk lasts for several years or longer after treatment is stopped. Lower rates of broken bones have been noted in patients taking raloxifene.\nTaking tamoxifen increases the risk of hot flashes, endometrial cancer, stroke, cataracts, and blood clots (especially in the lungs and legs). The risk of having these problems increases with age. Women younger than 50 years who have a high risk of breast cancer may benefit the most from taking tamoxifen. The risk of having these problems decreases after tamoxifen is stopped.\nTaking raloxifene increases the risk of blood clots in the lungs and legs, but does not appear to increase the risk of endometrial cancer. In postmenopausal women with osteoporosis (decreased bone density), raloxifene lowers the risk of breast cancer for women who have a high or low risk of breast cancer. It is not known if raloxifene would have the same effect in women who do not have osteoporosis. Talk with your doctor about the risks and benefits of taking this drug.\nAromatase inhibitors and inactivators:\nAromatase inhibitors (anastrozole, letrozole) and inactivators (exemestane) lower the risk of a new breast cancer in women who have a history of breast cancer. Aromatase inhibitors also decrease the risk of breast cancer in women with the following conditions:\nPostmenopausal women with a personal history of breast cancer. Women with no personal history of breast cancer who are 60 years and older, have a history of ductal carcinoma in situ with mastectomy, or have a high risk of breast cancer based on the gail model tool (a tool used to estimate the risk of breast cancer).\nIn women with an increased risk of breast cancer, taking aromatase inhibitors decreases the amount of estrogen made by the body. Before menopause, estrogen is made by the ovaries and other tissues in a woman's body, including the brain, fat tissue, and skin. After menopause, the ovaries stop making estrogen, but the other tissues do not. Aromatase inhibitors block the action of an enzyme called aromatase, which is used to make all of the body's estrogen. Aromatase inactivators stop the enzyme from working.\nPossible harms from taking aromatase inhibitors include muscle and joint pain, osteoporosis, hot flashes, and feeling very tired.\nSome women who have a high risk of breast cancer may choose to have a risk-reducing mastectomy (the removal of both breasts when there are no signs of cancer). The risk of breast cancer is much lower in these women and most feel less anxious about their risk of breast cancer. However, it is very important to have a cancer risk assessment and counseling about the different ways to prevent breast cancer before making this decision.\nThe ovaries make most of the estrogen that is made by the body. Treatments that stop or lower the amount of estrogen made by the ovaries include surgery to remove the ovaries, radiation therapy, or taking certain drugs. This is called ovarian ablation.\nPremenopausal women who have a high risk of breast cancer due to certain changes in the brca1 and brca2 genes may choose to have a risk-reducing oophorectomy (the removal of both ovaries when there are no signs of cancer). This decreases the amount of estrogen made by the body and lowers the risk of breast cancer. Risk-reducing oophorectomy also lowers the risk of breast cancer in normal premenopausal women and in women with an increased risk of breast cancer due to radiation to the chest. However, it is very important to have a cancer risk assessment and counseling before making this decision. The sudden drop in estrogen levels may cause the symptoms of menopause to begin. These include hot flashes, trouble sleeping, anxiety, and depression. Long-term effects include decreased sex drive, vaginal dryness, and decreased bone density.\nGetting enough exercise:\nWomen who exercise four or more hours a week have a lower risk of breast cancer. The effect of exercise on breast cancer risk may be greatest in premenopausal women who have normal or low body weight.\nIt is not clear whether the following affect the risk of breast cancer:\nCertain oral contraceptives contain estrogen. Some studies have shown that taking oral contraceptives (\" the pill\") may slightly increase the risk of breast cancer in current users. This risk decreases over time. Other studies have not shown an increased risk of breast cancer in women who take oral contraceptives.\nProgestin -only contraceptives that are injected or implanted do not appear to increase the risk of breast cancer. More studies are needed to know whether progestin-only oral contraceptives increase the risk of breast cancer.\nStudies have not proven that being exposed to certain substances in the environment, such as chemicals, increases the risk of breast cancer.\nStudies have shown that some factors do not affect the risk of breast cancer.\nThe following do not affect the risk of breast cancer:\nHaving an abortion. Making diet changes such as eating less fat or more fruits and vegetables. Taking vitamins, including fenretinide (a type of vitamin a). Cigarette smoking, both active and passive (inhaling secondhand smoke). Using underarm deodorant or antiperspirant. Taking statins (cholesterol -lowering drugs). Taking bisphosphonates (drugs used to treat osteoporosis and hypercalcemia) by mouth or by intravenous infusion.\nCancer prevention clinical trials are used to study ways to prevent cancer.\nBreast Augmentation is the most popular plastic surgery procedure performed worldwide.\nBreast augmentation can enhance your appearance and your self-confidence, enlarging your breasts and making them more proportional with the rest of your body. Breast augmentation can also be used to correct differences in the size of your breasts or sagging breasts, which can occur after pregnancy and breastfeeding.\nThere are many choices and options in breast augmentation, which require careful planning to individualize what are the best options for you. All of these choices have advantages and disadvantages, which you should understand before you make a decision with your surgeon.\nBreast augmentation does not correct severely drooping breasts. If you want your breasts to look fuller and to be lifted due to sagging, a breast lift may be required in conjunction with breast augmentation. Breast lifting can often be done at the same time as your augmentation or may require a separate operation. Your plastic surgeon will assist you in making this decision.\nMost patients choose silicone implants rather than saline implants because they have a more natural look and feel. Modern silicone implants are substantially different from the old type of silicone implants used in the 1970s and 80s. Another advantage of the cohesive gel silicone implants is that they are made in a variety of round and tear-drop shapes, which means it is easier to choose an implant to achieve the breast shape that you desire.\nMisinformation emerged about silicone in the late 80's and early 90's. The effects of silicone implants have since been studied extensively these claims were made, looking at 100,000s of women with breast implants. In June 1999, The Institute of Medicine at the National Academy of Sciences in the U.S.A. released a report, which confirmed that there is no increased risk of the development of cancer, immunologic or neurological problems associated with the use of silicone breast implants, which had been claimed in the late 80's. Patients with implants can breastfeed normally as there is no effect on breast milk.\nBreast augmentation surgery requires a general anaesthetic, with the operation taking 1-2 hours, and is usually performed as a day-stay or overnight-stay procedure.\nImplants are placed either behind the breast tissue or under the pectoralis muscle on the chest wall. Breast implants placed underneath the muscle have a more natural shape, a lower chance of capsular contracture (hardening) of the implant, and it is easier for mammography. There is also a choice of incision - in the crease under the breast, under the areola or in the armpit, all of which have advantages and disadvantages, which you should discuss with your surgeon.\nFollowing the surgery, it is important to have restricted light activities, with no lifting or heavy duties for 7-10 days. Most patients may drive again and return to work within 7 days after the surgery. Heavy activities and sport should not be undertaken for 3-4 weeks following the surgery. If you wish to discuss about any specific problem, you can consult a doctor and ask a free question.\nI am suffering from l5-s6 disc prolapse from a year. Not undergone surgery. Little weight lift becomes problem in next morning. Is there a permanent solution for my problem. Thanks in advance.\nHello, I am 41 yr. Old, female. I have got breast cancer & undergoing chemotherapy. I have completed 5 chemo out of 8. Since 2 days I am experiencing severe and unbearable pain in right leg. Is this a symptom of chemotherapy? We have tried all kinds of balm and oils, but nothing is working. Pls prescribe me some medicine or home remedy for it.\nI have some disc problem, in MRI report L5S1, how can I remove this problem, which exercise is useful in this problem.\nWhile you cannot cure breast diseases, family history and maturing, but there are some hazards or risks that you can control. Keeping in mind the fact that there is no certain approach to forestall breast cancer, there are things you can do that may bring down the hazard. Here are five approaches to ensure your breast's well-being:\n- Watch your weight: Being overweight or hefty expands breast cancer chances. This is particularly true after menopause and for women who have put on weight as grown-ups. After menopause, the vast majority of your estrogen originates from fat tissue. Having more fat tissue can heighten your chances of getting breast cancer by raising the estrogen levels. Additionally, women who are overweight have a tendency to have more elevated amounts of insulin, than other hormones. Higher insulin levels have been associated with a few tumors, including breast cancer.\n- Exercise routinely: Many reviews have found that exercise is the sign of having a healthy breast. Studies show that one to two hours of energetic walking each week, lessened a woman’s cancer risk by eighteen percent. Walking ten hours seven days decreased the hazard all the more.\n- Constrain liquor: Women who have two to five mixed beverages every day have a higher danger of breast cancer than women who have just one drink a day or none . As much as three to six glasses of wine seven days have been found to somewhat increase breast cancer chances. It is not clear how or why liquor raises the hazard. In any case, constraining liquor is particularly essential for women who have other hazard variables for breast cancer, like, breast cancer running in their families.\n- Restrain time spent sitting: Research has shown that sitting time, regardless of how much exercise you get when you are not sitting, increases the probability of growing cancer, particularly for women. Women who sit six hours or more a day outside of work have a ten percent more serious risk for breast cancer compared to the ladies who sit under three hours a day, and an increased hazard for other cancer types as well.\n- Stay away from or confine hormone substitution treatment: Hormone Replacement Treatment (HRT) was utilized frequently in the past to control night sweats, hot flashes, and other troublesome manifestations of menopause. In any case, specialists now realize that postmenopausal ladies who take a blend of estrogen and progestin might probably create breast tumors or cancer. Breast cancer disease seems to come back within five years in the wake of ceasing the blend of hormones. Therefore, get a breast cancer test even if you feel a small lump.\nComplete, permanent, easy, safe, fast & cost effective kidney failure\nHealth cure at aarogya super speciality modern homoeopathic clinic (computerised), Dr. Arpit chopra (md homoeopathy, 102, krishna tower, opposite curewell hospital, janjirwala chouraha, newpalasia, indore, you may check cured patients reports & feedbacks on website- www. Homoeopathycure. Com, email - arpitchopra23@gmail. Com, 9713092737, 9713037737, 9907527914 (whats up no, 0731-2532737, 0731-3961737.\nI have slipped disk and doctors told me to get admitted and I have another option to go to the bone setter what should I do?\nI am 29 years old. I am from bangladesh. I have a problem with my backbone. I have slipped disc. I have been suffering from this since 2011. I consulted with some local doctors. They prescribed me with some exercise but no improvement till now. I feel that a bone or two is/are displaced somewhere my waist. I need expert suggestion.\nHello Doctor I have degenerative disc disease after a fall down a flight of stairs in 2013. I sometimes have difficulty in breathing while asleep at night and develop colds frequently, is this due to the lumbar fracture? Also is inability to fill bladder a symptom of disc injury? Thank you for your time Doctor.\nDear sir. My mother is suffering from pain in waist and legs unable to stand for sometime and unable to walk due to L5 L6 displaced and make pressure on nerve. I don't want to operate for this . Is any other solution.\nThe uterus or womb, is a muscular structure and is held in place by ligaments and pelvic muscles. If these muscles or tendons become weak, they cause prolapse and are no longer able to hold the uterus in its place.\nUterine prolapse happens when the uterus falls or slips from its ordinary position and into the vagina or birth waterway. It could be complete prolapse or even incomplete at times. A fragmented prolapse happens when the uterus is just hanging into the vagina. A complete prolapse depicts a circumstance in which the uterus falls so far down that some tissue rests outside of the vagina. Likewise, as a lady ages and with a loss of the hormone estrogen, her uterus can drop into the vaginal canal. This condition is known as a prolapsed uterus.\nRisks: The risks of this condition are many and have been enumerated as follows:\n- Complicated delivery during pregnancy\n- Weak pelvic muscle\n- Loss of tissue after menopause and loss of common estrogen\n- Expanded weight in the stomach area, for example, endless cough, constipation, pelvic tumors or accumulation of liquid in the guts\n- Being overweight\n- Obesity causing extra strain on the muscles\n- Real surgery in the pelvic zone\nSymptoms: Some of the most common symptoms of prolapse involve:\n- Feeling of sitting on a ball\n- Abnormal vaginal bleeding\n- Increase in discharge\n- Problems while performing sexual intercourse\n- Seeing the uterus coming out of the vagina\n- A pulling or full feeling in the pelvis\n- Bladder infections\nNonsurgical medications include:\n- Losing weight and getting in shape to take stress off of pelvic structures\n- Maintaining a distance from truly difficult work\n- Doing Kegel workouts, which are pelvic floor practices that strengthen the vaginal muscles. This can be done at any time, even while sitting down at a desk.\n- Taking estrogen treatment especially during menopause\n- Wearing a pessary, which is a gadget embedded into the vagina that fits under the cervix and pushes up to settle the uterus and cervix\n- Indulging in normal physical activity\nSome specialists use the following methods to diagnose the problem:\n- The specialist will examine you in standing position keeping in mind you are resting and request that you to cough or strain to build the weight in your abdomen.\n- Particular conditions, for example, ureteral block because of complete prolapse, may require an intravenous pyelogram (IVP) or renal sonography. Color is infused into your vein, and an X-ray is used to view the flow of color through your urinary bladder.\n- An ultrasound might be utilised to rule out any other existing pelvic issues. In this test, a wand is used on your stomach area or embedded into your vagina to create images of the internal organ with sound waves.", "label": "No"}
{"text": "RHEUMA PAIN, RHEUMATOID PAIN RELIEF\nRheuma pain is sometimes harder when the weather changes. Rheumatoid pain relief enable bio energy healing. Rheumatoid arthritis is a chronic inflammatory disorder that can affect more than just your joints also affect bones, fingers on hand, spine. Difficult is moving, affect could be on sleep. What could casue rheuma? In some cases is caused from Geopathic stress zone, witch affect inflammatory on our bones during sleep.\nHOW TO NATURALLY RELIEF ARTHRITIS FROM KNEE, HIP, PAIN RELIEF, GET RID OF RHEUMATISM, WHAT KIND IS ALTERNATIVE HEALING AND CAUSES?\nWe recommend rheumatoid pain relief therapy with energy healing. Energy healer reduce too high potential in joints, lowered pain. Also raise immune system.\nEnergy healing works effective also on distance. As long term we recommended also Biostimulator. It neutralized geopathic stress zone also relief rheuma pain, improve sleep.\nIs a painful inflammation and degenerative processes caused by muscles, bones and joints, not only in adults but also at children. Rheumatism causes problems with movement of parts, joints of the body (stiffening knees, hips, shoulders, feet, fingers, vertebrae, spine, lower back pain, sciatica;). In rheumatic problems can also affect numerous past inflammatory diseases such as angina.\nIf so far as they were chronic nature, even after we get sick of angina, may occur at the same time pain in the form of rheumatism. People which have a pronounced rheumatic problems, often feel pain in the joints when the weather changes.\nOFTEN HIDDEN CAUSES OF RHEUMA PAIN\nChronic pain in joints, spine pronounced also in the morning? Have you thought that you can also sleep on Geopathic stress Zone?\nDISEASES LINKED TO GEOPATHIC STRESS ZONE – IN WORSE SITUATIONS OF EARTH NATURAL RADIATIONS – CANCER ZONE,\nWhile sleeping we may exposed to different types of natural Earth radiations – underground water veins, Hartmann and Curry lines, what in many cases causes various forms of chronic inflammation of joints as well as cancer diseases.\nRECOMMEND: Biostimulator – it works anti-inflammatory, naturally relief pain in joints, at rheuma pain, wheather changes, poor sleep\nMy husband had a constant pain in the neck and spine. After using Biostimulator, decreased pain and improved sleep well, he has no more cold feet .. lp, Irena S., Kamnik\nDid you think that it can be blamed precarious situation of the bed, lying on radiation, thereby causing inflammatory processes on the bones?\nRHEUMA PAIN – ARTHRITIS – ALTERNATIVE NATURAL TREATMENT\nRheumatic diseases generally known under the term arthritis, articular joint rheumatism, arthrosis, sciatica\nArthritis is a rheumatic disease, caused by inflammation of the joints. Problems usually occur in small joints (fingers, hands, toes, feet, elbows). In particular morning joint pain may be harbingers of arthritis.\nArthrosis, wear conclusions (frequent wear hip, wear knee) is a disease of the cartilage, caused by the lack of it.\nThis means that faster than cartilage formed is subject to wear. Frequent wear the knee arthrosis, arthrosis of the hip.\nProblems such. the knees are also very common in the case of certain sporting activities (for example, skiing, running, football – failure cruciate ligament tear, which can not be equated with rheumatism).\nOSTEOPOROSIS COULD CAUSE PARATHYROID GLAND\nOsteoporosis is the disappearance of bone mass, bone disease usually affects a larger number of the female population, osteoporosis bones become fragile. An additional problem of osteoporosis is that the process of the disease is not associated with pain and is hidden, a bone disease, which is, unfortunately, usually with age increase.\nTo reduce the problems of osteoporosis, it is advisable to change the eating habits of higher calcium intake of various origins (spinach, sardines, broccoli, etc.). and outdoor exercise (D absorption vitamin- sun).\nProblems with parathyroid also cause osteoporosis.\nHOW NATURALLY REDUCE INFLAMMATION, RELIEF, REMOVE PAIN IN THE KNEE, HIP, RENEW JOINT CARTILAGE ?\nAlternative healing treatment with bioenergy gives good results. With bio therapy we irradiated painful areas, while also being implemented to pain relief therapy and improves immune system.\nIt is crucial for healing any disease. Immune system has impact on all inflammation processes, chronic condition or autoimmune diseases. Usually already after the first treatment is easier moving, pain and inflammation is reduced.\nIrradiation of the knee or hip with bio energy healing significantly improve supply with nutrients and better blood flow joints, increase production of articular cartilage.\nWe recommend at least 5-7 cycles of therapy for complete regeneration of cartilage. Often this can avoid surgery (hip or knee replacement). Therapy is also recommended for the knee injury (work, sport), even after surgery because the recovery is up to 5x faster.\nBio energy healing treatment of knee or hips also work on distance!\nFELL THE DIFFERENCE OF MOVING – GET YOUR OWN EXPERIENCES\nGEOPATHIC STRESS ZONE – ANOMALY OF EARTH MAGNETIC FIELD – COMMON CAUSES DISEASES\nHave you thought about that certain EARTH RADIATION CAUSE EVEN rheumatic problems such as pain in the joints, muscles, joint stiffness?\n• Various harmful radiation, which we eventually exposed during sleep or work (office). Thus eliciting a variety of inflammatory processes, either in the bones or joints (hip, knee, shoulder, arm, leg ..) as well as you can in certain organs (lung inflammation , bladder, …). Pain in the hip, knee, shoulder, leg is more pronounced.\nIMPORTANT: Bone pain may also be due to some (UNDISCOVERED) DISEASE\nAt rheumatic diseases, we recommend the use of our bio energy system BIOSTIMULATOR, which works favorably – helps relief pain in the joints, bone pain and rheumatic diseases.\nREDUCE PAIN – life will be pleasant!\nGEOPATHIC STRESS ZONE – HIDDEN CAUSE OF DISEASES\nIn particular, water veins, Hartmann and cosmic radiation have influence on bones while sleeping. So may cause rheuma pain, arthritis, weakens immune system.\nExamples from practice also show many problems, diseases caused by Earth natural radiation – represent the real (hidden) cause in many cases for different kinds of disease.\nIMPORTANT: Bone pain may also be caused from undiscovered disease!\nAlso: if You suffer from cancer, not consum sugar, meat products..\nPROTECT YOUR HEALTH\n• BIOSTIMULATOR – In rheumatic diseases, we recommend the use of our bioenergy system Biostimulator, which works favorably – pain in the joints- reducing pain, bone pain and rheumatic diseases. Bio energetic shield, for better sleeping, it improve blood circulation – the body get more oxyigen, also serves as a protection , prevent against Geopathic stress zone (removal) – underground water veins, Hartmann lines and Curry lines crossing and as a bioenergetic support at diseases.\n• TELE – RADIESTHESIA (distant measurements radiation, dowsing in House, Apartment, Room, Bedroom, Office)\n• AURA EXAMINATION (exam organs and glands-discovering problems, diseases on time includes spine)\n• BIOTHERAPY / BIOENERGY ALTERNATIVE HEALING IS POSSIBLE ALSO ON THE DISTANCE!\nWith Biostimulator I am happy because I have a long night sleep and nothing hurt me in the morning as usual. It is a beautiful morning when you get up without pain..Regards, Maya, Slovenian Bistrica\nPicture example:The picture shows the cosmic radiation in the spine, which causes inflammatory processes and pain in these parts)\nLatest on blog\nDoes distance energy healing really work?\nEnergy treatment is done in terms of frequency diffusion. The disease has always a lower energy potential. When there is a lack of energy in the organ or gland, disease occurs. An energy healer strengthens the weakened parts of the body and supplies energy. It also works remotely.\nHenoch Schonlein Purpura\nHenoch Schönlein Purpura (HSP) causes inflammation of blood vessels -vasculitis, mostly in the legs, which appear as red-colored rash, the disease is more pronounced in children between 5 and 15 years of age. Symptoms and signs are usually fever, swelling around the knee and ankle and pain. In rare cases, it leads to complications such as internal bleeding. See more, how can be treatet on alternative natural way HSP ..\nAmyotrophic lateral sclerosis\nAmyotrophic lateral sclerosis is a neurological disease that is more common in men. Usually they may occur after the age of 40. Early symptoms and signs show the weakness in the hands or feet, muscle twitching, and consequently produced muscular atrophy. See more about natural healing ALS, which can cause disease, naturally treating nervous system, which enable bioenergy - alternative medicine.", "label": "No"}
{"text": "Beta Pet Maintenance 15kg\nAfter 30 days of feeding BETA, the good bacteria, bifidobacteria, may be multiplied by 100 times, helping to support your dogs healthy digestion.\nBETA 100% complete and balanced nutrition for adult dogs prepared with quality ingredients for good nutrient absorption.\nThis specially formulated recipe contains antioxidants to help support healthy natural defences.\nBETA Adult Maintenance product contains beet pulp to help regulate intestinal transit and improve stool quality.\nThe 100% complete and balanced formula ensures your adult dog receives all the healthy nutrition needed throughout his adult years.\nA complete product for a complete dog.\nDual sized kibbles support chewing and help nutrient absorption.\nCrunchy dual kibbles encourage chewing and healthy oral health", "label": "No"}
{"text": "Nutrient-dense, good food is certainly the foundation of weight loss. But an adequate amount of vitamin D can be difficult to ingest via food, especially for those who are vegetarian or don’t eat fatty fish (the main dietary source of vitamin D) on a regular basis. In the case of a lack of sun (such as during the darker months of fall and winter), it’s wise to supplement for multiple health reasons – and perhaps even for your weight.\nIf you want to lose weight, avoid special “low-carb” products that are full of carbs. This should be obvious, but creative marketers are doing all they can to fool you (and get your money). They will tell you that you can eat cookies, pasta, ice cream, bread and plenty of chocolate on a low-carb diet, as long as you buy their brand. They’re often full of carbohydrates. Don’t be fooled.\nThe benefits above are the most common ones. But there are others that are potentially even more surprising and – at least for some people – life changing. Did you know that a keto diet can help treat high blood pressure, may result in less acne, may help control migraine, might help with certain mental health issues and could have a few other potential benefits?\nObviously, it’s still possible to lose weight on any diet – just eat fewer calories than you burn, right? The problem with this simplistic advice is that it ignores the elephant in the room: hunger. Most people don’t like to “just eat less”, as it may result in having to go hungry forever. Sooner or later, a normal person will likely give up and eat, hence the prevalence of “yo-yo dieting”. While it should be possible to lose weight on any diet, some appear to make it easier and some to make it much harder.\nIt has totally regulated my appetite and normalised my relationship with food. My obsessive thoughts have completely subsided, my black and white thinking around food has gone, and I no longer binge! This is amazing. For the first time in my adult life I feel like I know what it is like to have a normal relatinoship with food. I eat when I eat, a range of healthy whole foods and occasional less healthy foods. In normal amounts. In manageable amounts. And when my meal is over, I stop! Normal for others, a seeming impossibility for me (and, I’m guessing, others with eating disorders).\nIF makes intuitive sense. The food we eat is broken down by enzymes in our gut and eventually ends up as molecules in our bloodstream. Carbohydrates, particularly sugars and refined grains (think white flours and rice), are quickly broken down into sugar, which our cells use for energy. If our cells don’t use it all, we store it in our fat cells as, well, fat. But sugar can only enter our cells with insulin, a hormone made in the pancreas. Insulin brings sugar into the fat cells and keeps it there.\nH. Guldbrand, B. Dizdar, B. Bunjaku, T. Lindström, M. Bachrach-Lindström, M. Fredrikson, C. J. Östgren, F. H. Nystrom, “In Type 2 Diabetes, Randomisation to Advice to Follow a Low-carbohydrate Diet Transiently Improves Glycaemic Control Compared with Advice to Follow a Low-fat Diet Producing a Similar Weight Loss,” Diabetologia (2012) 55: 2118. http://link.springer.com/article/10.1007/s00125-012-2567-4.\nIt usually takes three to four days for your body to go into ketosis because you have to use up your body's stores of glucose, i.e., sugar first, Keatley says. Any major diet change can give you some, uh, issues, and Keatley says he often sees patients who complain of IBS-like symptoms and feeling wiped out at the beginning of the diet. (The tiredness happens because you have less access to carbs, which give you quick energy, he explains.)\nAnother program called the 5:2 Fast Diet involves eating 5 days a week and fasting for the other 2 days, when women can get no more than 500 calories and men no more than 600. That’s a quarter of the amount you likely eat on the days when you don’t fast. Whether you eat those calories in one sitting or spread them across micro-meals throughout the day is up to you.\nJust taking the stairs instead of the elevator, or getting off the bus one stop earlier, is probably not going to change the numbers on your bathroom scale. It’s a myth. Studies show that if you just start exercising, you’re likely going to need at least 30-60 minutes of workouts per day to noticeably lose weight. Part of the reason is that exercise makes people hungrier, and eating more reduces the effect on weight.\nThe scale is not necessarily your friend. You may want to lose fat – but the scale measures muscles, bone and internal organs as well. Gaining muscle is a good thing. Thus weight or BMI are imperfect ways to measure your progress. This is especially true if you’re just coming off a long period of semi-starvation (calorie counting), as your body may want to restore lost muscles etc. Starting weight training and gaining muscle can also hide your fat loss.", "label": "No"}
{"text": "Are you or your partner pregnant and expecting a baby in Pennsylvania? Have you had a child and maybe now are wondering why that baby has not met certain developmental milestones? These are just some of the situations in which you should make sure you are educated about some of the types of birth injuries that may occur if proper actions are not taken. Certainly, you want to trust that your health care team can take care of moms and babies but the more patients know, the better because errors can and do happen.\nAs WebMD explains, as many as one out of every five cases of cerebral palsy may be attributed to a birth injury. One of the factors that may result in the development of cerebral palsy is the lack of oxygen to a baby either before, during or even just after birth occurs. When the flow of oxygen and therefore nutrients is cut off, a baby may experience brain damage. The results of this brain damage vary from baby to baby.\nMany children do not display symptoms of cerebral palsy for the first two or three years of their lives. Muscles may be extra stiff or floppy. Speech and vision may be hampered. Some children with cerebral palsy have learning disabilities or even mental retardation.\nIf you would like to learn more about what may lead a child to develop cerebral palsy and how to identify this condition, please feel free to visit the birth injury page of our Pennsylvania medical malpractice website.\nWritten on behalf of Friedman, Schuman, Applebaum & Nemeroff, P.C. Contact our firm for a consultation to discuss your legal matter.", "label": "No"}
{"text": "So our female Master is walking us girls pretty early one morning and well SnowPea found some new treat for us.\nDon't get to excited for us - these where given to our Master one day last week - but that's ok because we know where they are near us - however eating them off the ground is a bit tricky. But these are so good to eat. Both SnowPea and Milita eat these - SnowPea will eat Huckleberries too but Milita really does not care for them - STRANGE??? these are wild raspberries", "label": "No"}
{"text": "Which Is Better For Anxiety Hemp Or Cbd\nCbd Oil: What Are 9 Proven Or Possible Health Benefits?\nCannabidiol is a popular natural treatment used for lots of common conditions. Much better known as CBD, it is one of over 100 chemical substances understood as cannabinoids found in the cannabis or cannabis plant, Marijuana sativa (). Tetrahydrocannabinol (THC) is the main psychedelic cannabinoid discovered in cannabis, and causes the sensation of getting “high” that’s typically connected with cannabis – Which Is Better For Anxiety Hemp Or Cbd.\nThis quality makes CBD an attractive option for those who are looking for remedy for discomfort and other symptoms without the mind-altering impacts of cannabis or specific pharmaceutical drugs. CBD oil is made by extracting CBD from the cannabis plant, then diluting it with a carrier oil like coconut or hemp seed oil – Which Is Better For Anxiety Hemp Or Cbd.\nHere are seven health benefits of CBD oil that are backed by clinical evidence. More just recently, researchers have found that particular components of cannabis, including CBD, are accountable for its pain-relieving effects.\nStudies have revealed that CBD may help reduce chronic discomfort by affecting endocannabinoid receptor activity, decreasing inflammation and communicating with neurotransmitters (). For instance, one study in rats found that CBD injections decreased discomfort reaction to surgical cut, while another rat study discovered that oral CBD treatment significantly reduced sciatic nerve discomfort and inflammation (, ).\nWhat Does Cbd Stand For? – Cbd Acronym – Made By Hemp\nAn oral spray called Sativex, which is a mix of THC and CBD, is authorized in numerous nations to treat discomfort associated to numerous sclerosis. One research study of 47 people with numerous sclerosis examined the impacts of taking Sativex for one month. The individuals experienced enhancements in discomfort, walking, and muscle spasms. Which Is Better For Anxiety Hemp Or Cbd.\nAnother study discovered that Sativex significantly improved pain throughout motion, discomfort at rest and sleep quality in 58 people with rheumatoid arthritis (). CBD, particularly incombination with THC, may be efficient in reducing pain associated withdiseases like numerous sclerosis and rheumatoid arthritis. 2. Could Reduce Stress And Anxiety and Anxiety, Anxiety and anxiety prevail mental health conditions that can have devastating effect on health and wellness.\nWhat’s more, medications like benzodiazepines can be addictive and may result in substance abuse (). CBD oil has revealed promise as a treatment for both anxiety and stress and anxiety, leading numerous who live with these disorders to become thinking about this natural method. In one Brazilian study, 57 guys got either oral CBD or a placebo 90 minutes before they underwent a simulated public speaking test.\nThe placebo, a 150-mg dose of CBD, and a 600-mg dosage of CBD had little to no result on stress and anxiety (). CBD oil has even been utilized to securely treat insomnia and stress and anxiety in kids with trauma (). CBD has likewise revealed antidepressant-like results in several animal studies (, ).\nWhy Smoke Cbd Flower? – Plant Inspired Future\nUtilizing CBD has actually been shownto reduce stress and anxiety and depression in both human and animal research studies. 3. Which Is Better For Anxiety Hemp Or Cbd. Can Minimize Cancer-Related Signs, CBD may help in reducing symptoms connected to cancer and adverse effects related to cancer treatment, like queasiness, vomiting and pain. One research study took a look at the effects of CBD and THC in 177 people with cancer-related discomfort who did not experience relief from pain medication.\nCBD may also help in reducing chemotherapy-induced queasiness and throwing up, which are among the most common chemotherapy-related adverse effects for those with cancer (). Though there are drugs that help with these stressful symptoms, they are in some cases inadequate, leading some individuals to seek alternatives. A research study of 16 individuals going through chemotherapy found that a one-to-one combination of CBD and THC administered by means of mouth spray minimized chemotherapy-related queasiness and throwing up better than standard treatment alone (). Which Is Better For Anxiety Hemp Or Cbd.\nFor example, one test-tube research study found that focused CBD induced cell death in human breast cancer cells (). Another study revealed that CBD hindered the spread of aggressive breast cancer cells in mice (). However, these are test-tube and animal studies, so they can just recommend what might work in people – Which Is Better For Anxiety Hemp Or Cbd.\nThough CBD has actually beenshown to help in reducing signs connected to cancer and cancer treatment, and mayeven have cancer-fighting properties, more research study is needed to examine itsefficacy and safety. Acne is a typical skin problem that affects more than 9% of the population (). It is believed to be brought on by a number of factors, consisting of genes, germs, underlying swelling and the overproduction of sebum, an oily secretion made by sebaceous glands in the skin (, 23).\nCbd: Understanding How Cbd Works With Our Bodies\nOne test-tube research study found that CBD oil avoided sebaceous gland cells from secreting extreme sebum, exerted anti-inflammatory actions and prevented the activation of “pro-acne” agents like inflammatory cytokines (). Another research study had comparable findings, concluding that CBD might be an efficient and safe method to treat acne, thanks in part to its exceptional anti-inflammatory qualities ().\nCBD may havebeneficial effects on acne due to its anti-inflammatory qualities and itsability to control the overproduction of sebum from the sebaceous glands. 5. May Have Neuroprotective Residences, Researchers believe that CBD’s ability to act upon the endocannabinoid system and other brain signaling systems might offer benefits for those with neurological conditions (Which Is Better For Anxiety Hemp Or Cbd).\nThough research study in this location is still relatively new, several research studies have actually revealed appealing outcomes. Sativex, an oral spray including CBD and THC, has been proven to be a safe and efficient way to lower muscle spasticity in people with several sclerosis. One research study discovered that Sativex decreased convulsions in 75% of 276 people with numerous sclerosis who were experiencing muscle spasticity that was resistant to medications ().\n92. 3 grams of CBD oil per pound (25 g/kg) of body weight. Their seizures minimized by a median of 36. 5% (). Another study discovered that CBD oil substantially lowered seizure activity in kids with Dravet syndrome, a complex youth epilepsy condition, compared to a placebo (). However, it is necessary to keep in mind that some individuals in both these research studies experienced adverse reactions associated with CBD treatment, such as convulsions, fever and fatigue.\nDoes Cbd Get You High And How Does It Make You Feel?\nFor instance, a number of research studies have actually revealed that treatment with CBD enhanced lifestyle and sleep quality for people with Parkinson’s disease (, ) – Which Is Better For Anxiety Hemp Or Cbd. Additionally, animal and test-tube research studies have actually revealed that CBD may decrease swelling and help prevent the neurodegeneration connected with Alzheimer’s disease (). In one long-term research study, researchers provided CBD to mice genetically inclined to Alzheimer’s disease, finding that it assisted prevent cognitive decline ().\nCBD wasalso revealed to decrease the development of Alzheimer’s illness in test-tube andanimal studies. Might Benefit Heart Health, Current research study has connected CBD with several advantages for the heart and circulatory system, consisting of the capability to lower high blood pressure.\nOne current study treated nine healthy men with one dose of 600 mg of CBD oil and discovered it lowered resting high blood pressure, compared to a placebo. The very same study likewise gave the males tension tests that usually increase blood pressure. Which Is Better For Anxiety Hemp Or Cbd. Surprisingly, the single dose of CBD led the guys to experience a smaller blood pressure boost than regular in reaction to these tests ().\nIn addition, a number of animal research studies have actually shown that CBD might help in reducing the inflammation and cell death related to heart disease due to its effective antioxidant and stress-reducing residential or commercial properties (Which Is Better For Anxiety Hemp Or Cbd). For instance, one study discovered that treatment with CBD reduced oxidative stress and prevented heart damage in diabetic mice with cardiovascular disease ().\nWhy Smoke Cbd Flower? – Plant Inspired Future\n7 – Which Is Better For Anxiety Hemp Or Cbd. A Number Of Other Possible Advantages, CBD has actually been studied for its function in dealing with a number of health problems aside from those laid out above. Though more studies are needed, CBD is believed to offer the following health advantages: Studies recommend that CBD might help peoplewith schizophrenia and other mental conditions by minimizing psychotic signs ().\nIn rats, CBD has been shown to minimize morphine dependence andheroin-seeking behavior (). In test-tube and animal research studies, CBD has demonstratedanti-tumor impacts.\nCBD is usually well tolerated and thought about safe, it might trigger negative responses in some people. Side results noted in studies consist of (): Diarrhea, Changes in cravings and weight, Tiredness, CBD is likewise understood to interact with numerous medications.\nThis is especially important if you take medications or supplements that include a “grapefruit warning.” Both grapefruit and CBD interfere with cytochromes P450 (CYPs), a group of enzymes that are necessary to drug metabolic process (42). One study performed on mice revealed that CBD-rich cannabis extracts have the prospective to trigger liver toxicity.\nWhat Does Cbd Do? Cbd Oil And Cannabinoids Effectiveness\nCBD isgenerally thought about safe, it can cause unfavorable reactions like diarrhea andfatigue in some people. CBD oil has been studied for its possible role in reducing signs of many common health issues, consisting of anxiety, depression, acne and heart illness.\nThough there is much to be discovered the effectiveness and safety of CBD, arises from current studies recommend that CBD might provide a safe, effective natural treatment for lots of health issues. If you’re interested in trying CBD, you can purchase lots of items online, including gummies, oils, and lotions. Hemp-derived CBD items (with less than 0.\nMarijuana-derived CBD items are unlawful on the federal level, but are legal under some state laws. Inspect your state’s laws and those of anywhere you take a trip. Keep in mind that nonprescription CBD products are not FDA-approved, and may be erroneously identified.\nCBD is an abbreviation for cannabinoid. Today, you can find CBD oil in capsules, oil bases for vaporizers, tinctures, food products, and appeal items such as bath bombs or lotions., CBD is not envigorating or psychoactive.\nHow Does Cbd Affect The Brain? – Sf Weekly\nResearch study into some of these claims is continuous, and there is still a lot about CBD that we don’t know however scientists are attempting to discover out. Health Advantages Researchers are looking for answers when it comes to the complete potential of CBD.\nResearch studies showed it was reliable in contrast to a placebo in decreasing the frequency of seizures. Which Is Better For Anxiety Hemp Or Cbd.\nHealth Dangers Research surrounding CBD is continuous, and there are numerous concerns that researchers do not have the answers to yet, such as whether or not the methods of taking CBD impacts the threats or efficacy. Some common methods of taking CBD include inhaling through a vaporizer, consuming in food, or taking orally as a pill.\nA few of these threats are controllable if taking CBD under the assistance of your medical professional. Continued Throughout drug trials for Epidiolex, the FDA determined liver injury to be a negative effects of CBD (Which Is Better For Anxiety Hemp Or Cbd). Signs of liver injury appeared on blood work utilized to detect early issues with the liver.\nCbd Is In Everything, But It Hasn’t Really Been Proven To Do …\nIf you are taking other medications, CBD can impact their effectiveness, and the dose you are taking might require to be re-evaluated by your physician. CBD can possibly communicate with other medications to trigger negative effects. Since there is minimal research study on how CBD communicates with prescription drugs and with standard over the counter supplements, it is best to speak to your medical professional prior to taking CBD if you are taking other medications.", "label": "No"}
{"text": "Predictors of multiple concurrent and multiple sexual partnerships among male and female youth aged 18-24 in South Africa\nIf you would like to obtain a copy of this Research Output, please contact Hanlie Baudin at email@example.com.\nThis study aimed to determine predictors of multiple concurrent and multiple sexual partnerships among South African male and female youth. Data were from a cross-sectional population-based household survey of 3 123 youths aged 18 to 24 years from four South African provinces (males = 53.6%, blacks = 97.8%). Results from a sub-sample of being sexually active in the past 12 months (n = 1787) indicate that 5.3% (7.1% in males and 3.1% in females) youth participants had multiple concurrent sexual partners, and 38.8% (50.1% in males and 25.8% in females) had had two or more sexual partners in the past 12 months. Among females, multiple concurrent partnerships were only predicted by lower social network resources. Predictors of multiple sexual partnerships (two or more sexual partners in the past 12 months) among males included high HIV risk perception, never been tested for HIV and hazardous or harmful alcohol use. By contrast, among females, high peer pressure, lower education and ever having taken drugs predicted involvement with multiple sexual partners. Multi-level health promotion interventions are indicated for sexual behaviour change among South African youth.", "label": "No"}
{"text": "oral /ˈorəl, ˈɔr, ˈɑr-/\noral /ˈorəl, ˈɔr, ˈɑr-/ 形容詞\n1. Uttered by the mouth, or in words; spoken, not written; verbal; as, oral traditions; oral testimony; oral law.\n2. Of or pertaining to the mouth; surrounding or lining the mouth; as, the oral cavity; oral cilia or cirri.\nadj 1: using speech rather than writing; \"an oral tradition\"; \"an\noral agreement\" [syn: unwritten]\n2: of or relating to or affecting or for use in the mouth;\n\"oral hygiene\"; \"an oral thermometer\"; \"an oral vaccine\"\n3: of or involving the mouth or mouth region or the surface on\nwhich the mouth is located; \"the oral cavity\"; \"the oral\nmucous membrane\"; \"the oral surface of a starfish\" [ant: aboral]\n4: a stage in psychosexual development when the child's\ninterest is concentrated in the mouth; fixation at this\nstage is said to result in dependence, selfishness, and\naggression [ant: anal]\nn : an examination conducted by word of mouth [syn: oral exam,\noral examination, viva voce, viva]", "label": "No"}
{"text": "Researchers developed an aqueous system that uses a single starting point to induce self-assembly formation, whose stability is pre-programmed with a lifetime before disassembly occurs without any additional external signal - hence presenting an artificial self-regulation mechanism in closed conditions.\nResearchers succeeded for the first time in identifying the atomic structure and bonding mechanism in coherent interfaces between diamond, the hardest known material, and cubic boron nitride, the second hardest.\nUsing standard semiconductor manufacturing equipment, researchers have demonstrated a nano-mechanical plasmon phase modulator that can control and manipulate the flow of plasmons at the nanoscale without any degradation in optical performance.\nThe National Nanotechnology Initiative (NNI) invites members of the public to cast their votes for the winning images in the EnvisioNano photo contest. Students from labs and schools across the United States sent in pictures and descriptions of their research for the chance to win the top honors.\nInspired by the way living organisms have evolved in nature to perform complex tasks with remarkable ease, a group of researchers is exploring similar 'evolutionary' methods to create information processing devices.\nResearchers have carried out the first systematic study analyzing the safety of so-called upconversion nanoparticles that may be used to treat skin cancer and other skin diseases. This study is one of the most important steps on the path to new, safe and effective methods to diagnose and treat cancer.\nThis potentially scalable graphene production method consists in the exfoliation of low cost graphite using ultrasonic waves in synergy with a surface active and self-assembling protein extracted from an edible fungus.\nLife may seem precarious for the sea sponge known as Venus' flower basket. Tiny, hair-like appendages made essentially of glass are all that hold the creatures to their seafloor homes. But fear not for these creatures of the deep. Those tiny lifelines, called basalia spicules, are fine-tuned for strength.\nScientists have invented the first high-performance aluminum battery that's fast-charging, long-lasting and inexpensive. Researchers say the new technology offers a safe alternative to many commercial batteries in wide use today.", "label": "No"}
{"text": "Flowers Cleansing Balm (5 fl. oz.)\nHibiscus: contains a wealth of amino acids and vitamins that help defend skin from further damage by free radicals.\nPassion Fruit Oil: is packed with Vitamins A and C and provides lasting hydration. It is also highly emollient.\nMango Butter: is rich in essential vitamins, minerals, and fatty acids and can nourish skin to help reduce the appearance of aging.", "label": "No"}
{"text": "CBG & CBD GIGGIES contain one-to-one ratios of the two active ingredients in cannabis, CBD and CBG. They taste like sour cola and are THC-free. In addition, CBG gummies have an excellent absorption rate, so you won’t be left wondering whether they work. But before you make your purchase, you should know a few things. The first thing to look for is third-party lab testing. If a product is tested by an independent third-party laboratory, this is a sign of a high-quality product. This is especially important if you want to know the exact concentration of cannabinoids you are taking.\nCBG gummies contain one-to-one ratio of CBG to CBD\nCBD and CBG tinctures are complementary compounds found in hemp plants. The two work together in an entourage effect to enhance each other’s benefits. CBD and CBG gummies contain one-to-one ratios of both. These two compounds provide the body with a wide range of therapeutic benefits. Gummies containing a mixture of CBD and CBG may have additional benefits.\nStudies have indicated that both compounds have medicinal benefits, but they are not identical. While CBD and CBG both inhibit opioid signaling, they have different effects on appetite. For example, CBG acts as a neuroprotectant and antioxidant. It also blocks a2-adrenoceptors, which are responsible for muscle relaxing effects. While both can be psychoactive, they can produce euphoric feelings if taken in significant quantities. Because there are no known side effects of taking either, CBD and CBG gummies are a convenient way to supplement both compounds.\nThe company Extract Labs offers full-spectrum capsules with a one-to-one ratio of CBD andCBG. These capsules contain 33 mg CBD and CBG, and cost only $0.05 per milligram of cannabinoids. The company grows its hemp plants organically in Colorado. Its products are 100% organic and come with full third-party lab test data. The company has been in business for several years and has an extensive line of CBD products.\nThey taste like sour cola\nCBD and CBG infused ginseng gummies are a tasty way to consume CBD and cannabidiol. These edibles work directly with the body to help it regulate and balance various bodily processes. They taste like sour cola, and are a great way to start a new CBD and hemp habit. Many of the gummies contain both CBD and CBG, as well as other minor cannabinoids. They’re marketed as a way to aid in sleep.\nCBD and CBG tinctures are often derived from cannabis, but the process is not the same for cannabis-derived CBD. CBD gummies will go through the digestive tract before the active ingredients reach the bloodstream. This means that it may take up to an hour for the effects of CBD to be felt. It will also take longer to feel the effects of CBG gummies than other CBD products because they go through the digestive system first. Because CBD is absorbed through this process, it will remain in the body for up to six or seven hours. It may take a little longer to feel the effects of CBD, but the effects will last a little longer.\nThey work fast\nCBD infused dietary supplements are gaining in popularity for its ability to increase energy levels and stamina. It has been proven to delay the onset of neurological diseases such as Parkinson’s, Alzheimer’s, and other degenerative diseases. Vitamin E is a potent antioxidant and boosts energy levels during both the pre and post-workout period. Furthermore, it can prevent the onset of diabetes and cardiovascular disease.\nCBD oil works by unlocking the door that releases hormones. It does this by interfacing with neurons, which are nerve cells that transmit electrical nerve impulses throughout the body. There are billions of neurons in our central nervous system. The neurons are what make us feel emotions and senses. CBD oil, on the other hand, works by stimulating these nerve cells to release mood-enhancing hormones. In addition, CBD helps to clear mental fog.\nThey are THC free\nCBD infused gummies are an excellent way to take advantage of CBD without the high. These gummies are made using the same extraction methods as marijuana, but with lower THC concentrations. The most effective CBD gummies contain between 20 and 40 milligrams of cannabigerols, or CBG. There are a variety of flavors and concentrations to choose from, so it’s important to make sure you get a product that is right for you.\nCBG is a non-psychoactive cannabinoid found in the early stages of cannabis’ maturation. In combination with THC, it provides better rejuvenation. In short, CBD and CBG work together to create a perfect balance between the mind and body. These two cannabinoids are like bubble baths for the brain. And they can even be found in hemp, albeit in smaller quantities.", "label": "No"}
{"text": "Looking On The Bright Side of Wellness\nSeptember 14, 2018\nMeans Mothers Can Effectively Better their Appearance after Pregnancy\nAfter giving birth to the baby, the mother is likely to be under the pressure to have the body to normal body shape and appearance but the body has taken a different shape and appearance. The change cannot be well done even after the mother has undertaken all the different exercises that are advised by the doctors and taking the different types of meals that are needed hence needs to have a mommy makeover done. As the mother needs a makeover, the best way to have it done can be through having the mother perform some small tasks in the house. The weight that the mother had gained can be well reduced as the skin is being tightened through the small tasks that the mother is taking hence the loose skin at the abdomen can be well tightened. Health practitioners have stated, with the availability of common methods that can be used, the mother can have the skin well tightened hence can lead to the development of collagen As there are some common methods that the mother can use the skin can be well tightened hence leading to the development of collagen.\nIt is crucial to emphasize that after pregnancy, the mother is at a high affinity to get stretch marks on the body as the body has been under the pressure of gaining weight. The stretch marks can be often being brought around weight gain and pregnancy hence with the medical research that has been conducted states that stretch marks are not the easiest to treat. It is critical to emphasize that the mother is advised to have the area of risk to be moisturized hence keeping it from worsening and make the fade in appearance hence having the stretch marks present, there are different ways to tackle the stretch marks as there can be on non-surgical method to remove the stretch marks fully. There can be the use of skin-resurfacing treatments that the mother can use as the stretch marks not easy to be removed.\nHaving the makeover can an important issue as the several problems that are present can be removed but a tummy tuck is the most pressing issue that needs to be addressed. It is important to state, as the mother coming out of pregnancy the abdomen of the mother is likely of be full of fat hence making the abdomen to swell. The tummy tuck can be caused by having a liposuction which needs the removal of excessive fats from around the abdomen hence making the muscles to be tightened. After this procedure has been done the remaining part of the abdominal skin that can be sagging can be removed from the abdomen area. In summary, with the mother having this procedure done on her abdomen, the mother’s belly can be firmly attached hence making the abdomen to be free of any visible stretch marks that can be available on the abdomen.", "label": "No"}
{"text": "Welcome to the Otago Museum Shop\nAdding product to your cart\nPerfect for organizing accessories, small toys, plants and more. Roll the basket up or down to adjust the height.\nMade from 90% paper and 10% natural latex.\nHandwash and hang to dry.\nSize: Small 100mm x 100mm high.", "label": "No"}
{"text": "As September draws on, I thought that I would have a quick look back at some of our gardening projects, and see what worked and what didn’t. We have been trying to keep up recording our experiences in the garden diary, but that has been a rather patchy affair. I’ve just had a peek and discovered that the last entry was in July (thankfully it was at least July 2014 so it’s not as bad as it might have been). I felt compelled to scribble a brief note for yesterday’s date so honour was reasonably satisfied.\nNow for the 2014 season garden round up chez nous:\nFirstly, I will get the ‘non shows’ out of the way. We bought an aubergine and a pepper plant from Homebase and potted them up for the front garden. I know that this is crazily optimistic without a heated green house, but we have had some modest success in the past. Sadly, not this year; we didn’t grow even the tiniest pepper or aubergine. Well, a couple did begin to develop but fell prey to some strange munching creature. The same creature munched many of the Livingstone Daisies and the cowslip seeds failed to germinate. Overall however, this year was much better than last year, as early in the season a rogue wind blew over the mini greenhouse, scattering and damaging the contents of several seed trays.\nWithout doubt, our best success this summer has been our two pots of runner bean plants from which we have picked several portions. Last year we did well with broad beans, so there’s a compelling argument for going almost completely over to bean production. I wouldn’t say that we have produced a gargantuan crop, but we have had plenty of beans to add to our cooking. The red flowering plants are also an attractive feature in the spring. They do need some firm tying up however and you have to watch the pots in windy weather when they get top heavy. We also sowed mange tout later in the season after reading an article in (I think) the Irish Times gardening pages. We only made up one pot but have been picking pea pods until today and still should have more to come.\nOur potato variety this year as I have mentioned before was Blue Danube, bought from a very nice garden centre in Blessington. The resulting potatoes look more purple skinned than blue, but very appealing; the flesh inside is very white. In the last couple of years, we have planted potatoes in bags rather than in the border. We had three bags made up and have one left to harvest. I never feel that we do as well as we could with potatoes, but despite this, I like to grow them. We have had a go at some different varieties and we enjoy trying something new each year. Maybe next year we will manage to harvest a bumper crop.\nIn troughs and pots, we have grown spinach, baby carrots and leeks. We’ve been using carrots thinnings and picking spinach leaves during the summer. The leeks are still too small to pick. We grew them in a trough, aiming for a baby leek crop but there is still a way to go yet. A couple of years ago we decided to move from standard tomatoes to the cherry varieties, and this has worked well. We had two baskets of tumbler tomatoes hung on the frame of the swing and most of them have ripened. Thankfully, I won’t need my green tomato chutney recipe this year. I did find this year that it was harder to keep the baskets moist, so I think I need to improve the linings for next year. I have previously mentioned the strawberry plants that we have had for several years. We are finally going to bite the bullet and dig up and divide them ready for next year as it’s about time that job was done. Some of the plants are looking quite tired and I can see offshoots that will pot up nicely. One of the many jobs that needs to be done before the winter!\nI think that covers most of the vegetables and I hope to talk a little about our herb growing experiments another time. We’ll let you know what we‘re planning to grow in the garden next year as soon as we’ve made some plans.\nHow has your garden grown this year? Do tell us…", "label": "No"}
{"text": "What is the Best Nail Fungus Treatment?\nWhat is the best nail fungus treatment must be a proven nail fungus killer that promotes healthy nails. It shows how toenails and fingernails turn out better than it looks in as short as two weeks. Softer skin and trace absence of yellowish fungi that used to bother nails are the benefits derived from its use.\nNail Fungus Treatment Products\nNail fungus treatment products that are much handier to use than what have been traditionally adopted by many has arrived in a world where people accustomed to having homemade hand and foot soaks. With simple instructions that come with the pack and with ideas on the benefits achievable from the use of the product, they have become available for purchase. Having a bunch of them in competition in the market, has provided a problem as a hard time to make the proper choice has been afforded to consumers of having all these handier options at arm’s reach.\nFeatures of What is the Best Nail Fungus Treatment\nThe pack of what is the best nail fungus treatment must consists of safe and natural ingredients such as nail fungus fighting oils that surely does their work while the use of the handy product is being enjoined.\nWhat is the top nail fungus treatment must be a proven nail fungus treatment, working to make sure that the fungus is cleared from its source. It must be handy with its brush applicator being a natural, safe and effective solution.\nWhat is the best nail fungus treatment can be brought anywhere making sure it can be used to kill nail fungi. For the ability of seeing best results, nails must be made clean and dry before application of the product.\nThe benefits derived from what is the greatest nail fungus treatment are restoration of the nails and the enjoyment of wearing open toed shoes and sandals as well as the boasting of nail fungus free hands to family and friends.\nTwo Options for What is the Best Nail Fungus Treatment Available on the Market\nClaripro Nail Fungus and Clear Solution represents what is the cheap nail fungus treatment with high quality offering an oral spray and a clear nail fungus solution in the packaging. Claripro is a bit cheaper product compared to its competition.\nIts oral spray is a homeopathic solution dropped under the tongue twice a day while its clear nail fungus solution is applied using a convenient brush built into its lid. The inducement of the natural immune response of the body to the cure of the nail fungus from the inside is provided by this great homeopathic solution while it works by attacking the nail fungus from the outside.\nZetaClear Nail Fungus Treatment represents what is the free nail fungus treatment from care being a product available either as a topical solution or as a spray, making it easier to get rid of nail fungi. Now a two step solution to the nail fungus problem, the topical solution offers a variety of essential oils inside its bottle, including jojoba oil, tea tree oil, lemongrass oil and clove oil while the spray contains sulphur, mancinella and arbor vitae among others.\nZetaclear offers a string of benefits to its end users including the annihilation of nail fungus while clearing the nails of the yellow keratin debris that has developed inside them and the application ease provided by a topical brush available inside each bottle.\nRecommendation for What is the Best Nail Fungus Treatment\nClaripro works for the permanent eradication of toenail fungus. The root cause is the problem that is causing the fungus infection and it is what is being attacked by Claripro is its objective of getting rid of the toenail fungus. Once the source of the trouble is killed, the problem and all its symptoms are gotten rid of just like any other life problem.\nGiving the chance for the fungus to become more severe and likely to spread to other toenails, making it harder to get rid of, would be the consequence of doing nothing about toenail fungus. Our recommendation for what is the best nail fungus treatment is the Claripro Nail Fungus and Clear Solution.\nOur Recommendation : Claripro\nIncoming search terms:\n- what is fungi\n- what is fungus", "label": "No"}
{"text": "Inmates at the Pulaski County Jail started work this week to help supplement their diet and improve the quality of their meals.\nThis is the second year for a garden run by the Pulaski County Jail. The crops are grown at the site of the former Pleasant View Rest Home, the produce from which is used as part of meals served at the jail.\nVarieties include potatoes, green beans, peppers, onions, lettuce, cabbage, tomatoes, cucumbers, and watermelons. Sometimes hundreds of pounds of each variety are produced according to the Pulaski County Sheriff’s Department.\nApart from improving the quality of the food, the jail experiences a cost savings for their meal plans each year due to the growth of the garden. This year’s crops are supposed to produce more food than the previous year.\nAlso this year, a Winamac-based Eagle Scout planted pear, apple, and peach trees. It will be several years before they production fruit, but is expected to add responsibility to the inmates working the gardens.", "label": "No"}
{"text": "How to get rid of a spot mark20.11.2020\nHow to Fade Dark Spots With Ingredients You Already Have in Your Kitchen\nAug 23, ·, treatment of any dark spots should start with a vigilant sun-protection routine. Wearing sunscreen with an SPF of at least 30 each day, regardless of if . 7 Home Remedies for Dark Spots, According to a Dermatologist.\nHowever, some dermatologists use much more acceptable terms such as wisdom mark or knowledge spots. Well, what is skin barnacles? What are how to get rid of a spot mark causes? Who is susceptible to get seborrheic keratosis? What are the symptoms and signs? Is there any complications if I already have skin barnacles, Where it is commonly developed? How I can get rid of skin barnacles? Is there any home remedies I can use?\nAll these questions will be covered within this article…keep on reading. Seborrheic keratosis is a natural skin condition that mainly appears as a side effect of skin aging process and it is characterized by its bumpy, waxy, scaly shape with a certain color that ranges from many shades amrk brown to black. The shape and name of this skin condition may seems to be dangerous. However; it is extremely common skin condition among people so you do not have to worry about it.\nMoreover, it has no gender bias but it is noticeable how to remove candle wax from cloth tablecloth males and females of old age. Unfortunately, studies show that too causes of skin barnacles are unknown and not defined yet.\nThe question behind the unknown causes of the disease have been developed and many scientists kept jow. As a result they found that Seborrheic Keratosis is related neither to how to test a gui dermatitis nor to sebaceous hyperplasia! However, some of them notice aa there are conditions associated with the appearance of skin barnacles as follow:. Well, you have now to know the signs and symptoms of seborrheic keratosis ….\nThey are easily detected as you will notice that these growths on your skin are brown with an appearance that looks like a wart, they appear randomly on different rix of your body. You will notice that their number increase as you yet, you may also experience some signs such as: swelling, pain, itchiness and the feeling of discomfort. However, your dermatologist may ask you to perform a biopsy to just confirm its diagnosis and make sure that it is seborrheic keratosis, not skin melanoma.\nNevertheless, generally, you do not have to worry about it and make sure that it is a common skin condition. The removal of seborrheic keratosis could be done in various ways if you feel discomfort with it or if you find that seborrheic keratosis grows quickly, turns black, off, or bleeds, making it difficult to distinguish from skin cancer.\nOn the other hand, you can also leave it if you can deal spt it and you do not face any kind of problems. The most common removal methods are Cryosurgery, Electro-surgery, and curettage. Liquid nitrogen is a cold liquid that is used under your dermatologist consultant where it is applied on the skin barnacle. After few days the skin barnacle falls forming a blister that dries over time then falls by time too. Sometimes a hyperpigmentation may occur that may fade over time od it may remain and leave a scar off this considered as a side effect for this type of treatment.\nIt is mmark as one of the treatment procedures that is accomplished by using a metal hand tool with a small loop at the tip called curette that works on the affected area and by the aid of local anesthesia.\nCurettage can achieve the target goal without producing any kind of scars. However, the procedure requires a good sterilization as it there is a small risk of wound infection or even a viral infection if bleeding occur.\nIt is considered as one of the treatment procedures that is accomplished by using a device that apply certain electric current and a local anesthesia to the affected area, as a result, it destroys the affected tissue.\nThe procedure does not produce any kind of scars or even bleeding. Fid method eradicates the lesion using a blade with the aid of local anesthesia, the procedure is safe and quick with a good result but its cost is a little bit higher than the previously mentioned procedures.\nThere are many removal procedures but the previously mentioned are the most common, make sure to visit more than a dermatologist for a consultantancy because each case and each procedure is mari from one another. Is there a home remedy for these dark scaly spot Sppt I am 83 and still very active. I have a raised scaly spot on my face and neck and others are beginning.\nIs there any treatment at home? Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. August 31, Skin Care 3. Related Posts. Leave a Reply Cancel reply Your email address will mafk be published. Forgot your password? Registration is free and easy! Faster checkout Save multiple shipping addresses View and track orders and more Create an account.\nFacebook icon Login with ,ark. Google icon Login with Google. Search for:. How to tie a shoe instructions cart close.\nHow do you get rid of dark spots fast?\nAug 31, · Use a daily lotion that prevents the buildup of dead skin and help soften your skin like a glycolic 10% (alpha hydroxy), beta hydroxy, or Amlactin. Make sure to use a strong exfoliating product but do not over scrub.\nWe understand, white spots on the face can be irritating! Be it the patches of discoloration, the small bumps or all the different forms they come in. Milia is usually seen on babies but are also found on adults.\nAlso called milk spots, they usually appear around the eyes, cheeks and nose. Milk spots on face are formed when keratin a protein in the upper layer of the skin and dead skin cells get trapped below the skin surface. Milia can manifest due to an allergic reaction to a harsh skincare product or due to sun exposure. Extraction of keratin: A certified dermatologist will use a medical grade needle to extract the keratin.\nRetinoid cream: This can be used on areas other than those surrounding the eyes. Pityriasis Alba latin: scaly patches is a skin condition and a type of eczema that causes flaky patches of discolored skin. The exact cause of this skin condition is unknown. But it is attributed to sun exposure leading to hypopigmentation.\nThinking about how to get rid of pityriasis alba? Pityriasis Alba clears on its own and does not require medical attention. Applying moisturizer and topical steroid like hydrocortisone can reduce the itchiness if any. Vitiligo is a skin condition that leads to loss of pigment melanin in the skin. These patches or small white spots on face remove start small and can spread to other parts of the body. Doctors believe that vitiligo on cheeks forms when antibodies that destroy melanin are produced in the body.\nPeople with a family history of vitiligo have a high chance of getting it. It is advised that people with vitiligo always wear sunscreen as direct sun rays will cause damage and burn the affected skin. Tinea versicolor is a condition in which lighter or darker patches are formed on the skin. They occur due to a kind of fungus on the skin and is not contagious in most cases.\nDermatologists recommend anti fungal creams, shampoos, soaps, etc. Antifungal medication like fluconazole can also be used to stop and prevent this condition. Tinea versicolor may occur in pregnant women, but the condition is restored after the hormone levels are back to normal. Although the cause of Idiopathic guttate hypomelanosis is unknown, it is believed to be related to prolonged UV exposure.\nTopical steroids can be used to reduce skin inflammation. Retinoids work by stimulating cell growth and hyperpigmentation. The best way to prevent this skin condition is by using a sunblock. Most white spots are harmless and you can stop wondering what they are. But consider making a visit to your dermatologist when the spots begin to grow in size or spread. Begin By Knowing Your Skin. This offer is only valid till 30th April The good news is that these spots have effective treatments.\nRead on to know more about them. Is It Contagious? Was this Article helpful? How can we make this page better? What did you like about this page? Order Now.", "label": "No"}
{"text": "- 100% Plant-based\n- Made with natural ingredients\n- Made with low glycemic coconut sugar\n- Vegetarian and vegan friendly (No any kind of dairy such as eggs, butter or milk from animals)\n- Zero cholesterol\nWhole wheat flour, almond flour, vegan cashew butter, flax eggs(flaxseed), organic coconut oil, almond milk, coconut sugar, sea salt, vanilla, baking powder, baking soda and roasted almond nuts.\nAlmonds contain lots of healthy fats, fiber, protein, magnesium and vitamin E.\n-Almonds are a fantastic source of antioxidants.Antioxidants help protect against oxidative stress, which can damage molecules in your cells and contribute to inflammation, aging and diseases like cancer.\n-Almonds are low in carbs and high in protein and fiber\n-Almonds can lower cholesterol levels\n-The magnesium in almonds may additionally help lower blood pressure levels.\nHow to keep them?\nOur treats needs to be refrigerated if you want to prolong the shelf life.You need to transfer it in an airtight container to prevent from getting dry quickly.\nChiller - Can last up to 7 days\nFreezer - Can last up to 1 month", "label": "No"}
{"text": "The world of seafood seems daunting at first glance. Take salmon for example. There are multiple species of salmon being sold from multiple parts of the world. In addition to those two characteristics, there are a world of options when it comes to how the fish was raised or caught, where it comes from, how it’s shipped, how it’s packaged, etc. Today we’re exploring a topic you might have heard before; farmed vs. wild salmon.\nFarmed or Wild Salmon\nThe terms “farmed” and “wild” refer to how the salmon is raised or caught prior to arriving in grocery stores, fish markets, restaurants, and online salmon delivery services like Secret Island. Ultimately, no matter the type of salmon you buy, you still have the opportunity to enjoy delicious and healthy seafood, which dieticians recommend eating 2x per week, but there are a few key differences.\nFarmed Salmon Explained\nSecret Island utilizes a sustainable and transparent farming process. In terms of sustainability, farmed salmon has numerous advantages. Not only does Secret Island lead the industry with the latest energy and resource-efficient technology, but the act of farming salmon benefits both the local fish population and seafood lovers across the world. According to the Global Salmon Initiative (GSI), farmed salmon also:\n- Helps meet rising global demand for seafood\n- Creates more resilient global food systems\n- Combats overfishing and over-exploited wild fish reserves\n- Contributes to healthy aquaculture methods, which in turn protects salmon as a species\nWild Salmon Explained\nYou may be surprised to learn that farm-raised salmon actually contains more protein and higher levels of Omega-3s per serving than wild salmon.\nSo why has wild-caught salmon received all the buzz in recent years as a trendier or even “healthier” variety? Well, it could just be a personal preference – or a lack of knowledge of just exactly how salmon are sustainably farm-raised – but the truth of the matter is that even though farmed and wild salmon may seem very different, they are actually quite a similar product.\nThe main issue with wild-caught salmon, as mentioned before, is the way the commercial fisheries are managed and maintained by state and federal authorities. The potential for over-fishing (or depleting the natural resource faster than it can be replenished – thus reducing the overall biomass of fish and destabilizing fragile ocean ecosystems) is real. So if you choose wild salmon over sustainably farmed, just make sure you’re sourcing it from a well-managed fishery.\nTrends show that more people are opting for healthier protein options like seafood – and salmon in particular – so it raised the question of how wild-caught salmon alone would be able to meet the increasing demand.\nWhich Should I Buy?\nAt the end of the day, eating salmon is part of a heart-healthy diet and that goes for both farmed and wild-caught salmon. Being knowledgeable about where and how your salmon got to your plate is the best way to ensure you’re eating high-quality seafood. The American Heart Association recommends eating fish twice a week to reduce the risk of cardiovascular disease.", "label": "No"}
{"text": "The first meal of the day especially when taken in the morning is known as Breakfast. Breakfast is the first meal of the day. Breakfast is usually served between 07:00AM or 07:30AM, to 10:00AM to 10:30AM. There are 3 types of the most popular breakfast:\n- Continental Breakfast.\n- English Breakfast.\n- American Breakfast.\nWhen it comes to a healthy diet, when you’re having your meal is as important as what you’re eating. The best time to have breakfast is within two hours of getting up. The sooner you eat breakfast after you wake up, the better it is for your metabolism.\n1. Continental Breakfast:\nA light breakfast (as of rolls or toast and coffee). The continental breakfast is a light option typically consisting of pastries and baked goods, fruits, toast, and coffee. It is usually served buffet-style and modeled after the European help-yourself breakfast, similar to what one would enjoy in France or in the Med.\n2. English Breakfast:\nA full breakfast is a substantial cooked breakfast meal, often served in the United Kingdom and Ireland, that typically includes bacon, sausages, eggs, black pudding, baked beans, tomatoes and mushrooms, toast, and a beverage such as coffee or tea.\n3. American Breakfast:\nBy definition, an American breakfast involves two eggs, a side of bacon or sausage, toast or cereal and your choice of juice. Pancakes may be offered as a side or alternative. American breakfast beats continental breakfast, but may tie, draw or lose with full English, depending on your tastes. Cold cereal, it finds, tops the list of most common breakfast foods, cited by 31 percent of those who eat breakfast. About two in 10 usually eat eggs (with or without bacon or ham) and just over one in 10 usually have a bagel, toast, muffins or pastry. Eaten cold pizza with you.\n4. Pakistani Breakfast:\nA typical Pakistani breakfast, locally called nāshtā (ناشتہ), consists of eggs (boiled/scrambled/fried/omelette), a slice of loaf bread or roti, parathas, sheermal with tea or lassi, kulcha with chole, qeema (minced meat), fresh seasonal fruits (mangoes, apples, melons, bananas, etc.), milk, honey, butter, jam, shami Kabab etc.\n5. Indian Breakfast:\nA typical breakfast in India varies depending on region, but is often quite similar to a lunch or dinner. A breakfast plate in India might include roti (flatbread), dosas (thin crepes made of lentils) or idlis (steamed rice-dough pancakes), and different dips and chutneys, as well as spiced potatoes.\nHere are a list of some regular daily basis easiest and healthiest breakfast;\n- Muffins or scones.\n- Baked oatmeal.\n- Breakfast cookies.\n- Pancake mini muffins.\n- Homemade egg Muffin or other breakfast sandwich.\n- Make-ahead breakfast wraps or quesadillas.\n- Freezer breakfast burritos.\n- Mini egg cups (with veggies, sausage, bacon, etc).\n- Chia Seeds.\n- Green Tea.\n- Greek yogurt.\nImportance of Breakfast:\nBreakfast is often called the most important meal of the day, and for good reason. As the name suggests, breakfast breaks the overnight fasting period. It replenishes your supply of glucose to boost your energy levels and alertness, while also providing other essential nutrients required for good health. People who consume breakfast regularly often have increased physical activity. They have better dietary profiles and lower intake of snacks. Skipping breakfast is associated with increased disease risk not only obesity but diabetes, heart disease and just lower dietary quality.\nMany studies have shown the health benefits of eating breakfast. It improves your energy levels and ability to concentrate in the short term, and can help with better weight management, reduced risk of type 2 diabetes and heart disease in the long term.\nBenefits of eating Healthy Breakfast:\nBreakfast replenishes the stores of energy and nutrients in your body. Reasons of eating breakfast are as under;\n- Brain- boosting powers, as you stare off into space at your work desk, you may wonder why you can’t focus on a darn thing.\n- Breakfast helps you make better food choices.\n- A healthy breakfast may reduce the risk of illness.\n- Source of essential vitamins and nutrients.\n- Help your heart.\n- Reduce metabolic syndrome.\n- Less likely to develop eating disorders.\n- Enhance immune system.\n- Improve your skin.\n- Keep yourself thin.\n- Helps to decrease appetite.\nWhat happens if you skip breakfast?\nSkipping the morning meal can throw off your body’s rhythm of fasting and eating. When you wake up, the blood sugar your body needs to make your muscles and brain work their best is usually low. Breakfast helps replenish it.\nIn general, there are no benefits to skipping breakfast, or any meal throughout the day. If you prefer to get up earlier and exercise in the morning and don’t have time to eat beforehand, it’s very individual if you feel that you can exercise on an empty stomach or not.\nCan you lose weight by skipping breakfast?\nThe researchers ultimately concluded that skipping breakfast won’t have a significant effect on weight loss. People who skip breakfast don’t feel hungrier in the afternoon. They don’t feel less energetic. And here’s the kicker: On average, people who skip breakfast consume 260 less calories each day, which meant they lost a couple pounds a month.\nSkipping breakfast has been linked to elevated blood pressure, higher levels of total and low-density lipoprotein cholesterol – known as “bad” cholesterol – and changes in appetite that cause people to overeat later in the day.\nThings that Happens to your Body if you Skip Breakfast:\nHere’s a breakdown of everything that may happen when you skip breakfast. Just be sure that if you do decide to eat something in the morning, it’s not any of the worst breakfast foods you should never start your day with.\n1. Risks of Diseases:\nBreakfast skippers have been found to have a higher risk of type 2 diabetes, higher risk of obesity due to insulin resistance and hormone regulation, as well as increased risk for heart attacks and hypertension.\n2. Your Productivity Goes Up:\nSome say that skipping breakfast can make you more compliant when it comes to adhering to their nutrition plans. For those who aren’t hungry upon waking, eating breakfast can feel forced and uncomfortable.\n3. Your Cortisol Rises:\nIf you don’t eat breakfast, then cortisol levels will continue to increase to maintain blood glucose levels eventually causing insulin resistance that makes you more hungry throughout the day. The brain needs glucose to survive through the night and sometimes there isn’t enough stored glycogen in the liver to maintain adequate blood glucose levels.\n4. Level of Acidity Increases:\nNot eating breakfast can cause increased bouts of acidity. The body is mechanized to release acid in the stomach for digestion when the body feels hungry and needs fuel, if we starve or don’t eat for several hours it will surge up to the walls of the nearby areas like the stomach.\n5. Headaches Or Migraine:\nLack of fuel such as glucose to the brain will lead to a decrease in the functioning of the brain cells which is why you may experience headaches or migraine.\n6. Bad Breathe Comes:\nAs if bad breath wasn’t already a huge morning problem, your halitosis will only get worse when you skip breakfast. There’s nothing which can neutralize that morning odor when you don’t eat something first.", "label": "No"}
{"text": "Where is Laboe Naval Memorial?\nLaboe is home to Laboe Naval Memorial. Spend the day exploring the area and seeing some of the local attractions. If you want to find things to see and do in the area, you might like to visit German submarine U-995 and Schilksee Beach.\nThings to see and do near Laboe Naval Memorial\nWhat to see near Laboe Naval Memorial\n- German submarine U-995\n- Kieler Förde\n- University of Applied Sciences\n- Brasilien Beach\n- Aquarium GEOMAR\nThings to do near Laboe Naval Memorial\n- Zoological Museum of the University of Kiel\n- Kiel Opera House\n- CITTI-PARK Kiel\n- Old Botanical Garden", "label": "No"}
{"text": "Dentitox Pro is a daily oral care item that uses nutrients from plants that help consumers improve their teeth as well as gum tissues without replacing the individual’s existing regimen. The formula is simple to apply each day, though customers will certainly need to stay on par with using this remedy consistently to make a difference.\nWhat is Dentitox Pro?\nOral health is just as vital as physical conditioning and the right nourishment for the body. The method a person takes treatment of their teeth can make a difference in their wellness because every nutrient they take in goes through their mouth. The mouth is likewise loaded with various kinds of microorganisms, and also these microorganisms can accumulate and also trigger tooth cavities otherwise looked after properly. Using Dentitox Pro can be a helpful option for individuals that want to improve their oral health and wellness.\nThere is astonishingly little details available with Dentitox Pro. Still, it was established by Marc Hall, who wants the modifications that plants can have in customers’ health almost everywhere. The treatment contains lots of common active ingredients that users discover in toothpaste and also mouth wash, however a number of various other plants make a huge distinction.\nExactly How Dentitox Pro Works\nThe Dentitox Pro formula focuses on providing nutrients that the body requires. Within simply 6 declines of the formula, customers will certainly get a ton of various nutrients that their body already requires to keep for much better health and wellness, like vitamins A, C, k2, and d3 . It also includes lots of minerals like potassium as well as calcium.\nNevertheless, with all of these regular ingredients, customers would relatively get the exact same assistance from merely using a multivitamin. That’s why there are added active ingredients that make the performance of this solution even more intense, consisting of:\n- Ironized phosphoric acid\n- Indian licorice root essence\n- Cinnamon essential oil\n- Peppermint important oil\nWhenever the user makes a decision to include the Dentitox Pro drops in their regular, they must apply them directly to the teeth and also periodontals . Brushing the teeth is still needed to maintain oral health, but Dentitox Pro provides a means to boost that wellness.\nRead on below to find out about each of these components’ duty in dental and oral health and wellness.\nElderberry covers a number of different sorts of trees, covered in white blossoms and deep-blue berries . It is often used to supply vital anti-oxidants to the customer, though some recommend that it can improve the immune system. The berries can not be eaten in their natural state, so they are generally utilized as a supplement.\nAs valuable as elderberry might be, some customers can have an unfavorable response to it if they consume greater than they intended. Some of the indications that individuals may have taken in excessive include nausea, amazement, lightheadedness, and weak point .\nIronized Phosphoric Acid\nPhosphoric acid originates from phosphorus, which the body uses with calcium to keep the teeth and bones strong. It keeps kidney function controlled, and it aids the body shop energy safely.\nXylitol is mainly used as a low-calorie replacement for sugar, providing individuals with an choice that is low in sugar. Most of the time, this ingredient is made use of in gum tissues as well as similar products to keep the teeth as well as gum tissues healthy and balanced. Researches reveal that xylitol can minimize the harmful microorganisms in the mouth by depriving it of the nutrients that it would require to make it through. It likewise can reduce plaque as well as ultimately avoid dental cavity, which implies that individuals have a better form of security versus inflammatory gum tissue disease.\nThis active ingredient is also helpful in stopping ear infections, and also it sustains the body’s requirement for anti-oxidants. It is additionally a type of sugar alcohol, though it doesn’t actually include any alcohol whatsoever. Sugar alcohols are simply a type of carbohydrate.\nSince it boosts and also decreases creases skin wellness, the majority of people assume of collagen as a skin care component. It is additionally directly related to relief from joint discomfort, though it might be utilized in this dental wellness supplement to stop bone loss. As time goes on, bone thickness boosts, even if it has deteriorated with age.\nMaking use of a supplement is the most convenient method to boost collagen degrees, assisting the body enhance hydration.\nMSM is typically consisted of to lower discomfort in the joints, complementing the use of collagen perfectly. It can minimize swelling, which commonly takes place in irritated gum tissues when they become infected. MSM is occasionally connected with relief from allergy signs, and also it can boost the body’s capacity to recuperate after an intense workout.\nThe research study behind MSM reveals that this nutrient also has a powerful effect on the body immune system, which suggests that individuals will recover much faster when they need dental care.\nIndian Licorice Root Extract\nIndian Licorice Root Extract provides lots of antioxidants to lower swelling and also provides the user with antimicrobial benefits. When utilized consistently, there’s a chance that this extract can reduce the risk of infections in the top respiratory system system, and also it can boost the manner in which the body digests various nutrients.\nDigestion has a major duty in the health of the mouth. These germs can after that penetrate the periodontals and mouth, triggering damage to the teeth.\nNeem is a fallen leave, and also it is used for the treatment of many ailments for the body. A few of the issues that it can assist to handle include appetite loss, skin ulcers, digestive worms, upset stomach, and also diabetes mellitus. The most significant reason this ingredient is probably consisted of in the formula has to do with the nutrients it supplies people that experience gingivitis.\nGingivitis is a sort of periodontal disease, and it usually creates redness, inflammation, and also irritability around the bottoms of the teeth. While it can be turned around, consumers require to enhance their dental hygiene to protect them from reappearance.\nSage has lots of nutrients that the body can benefit from. Because it can lower the microbes accountable for dental plaque, sage is extremely advantageous for dental health. Generally, it can be made use of topically in mouth washes to exterminate the bacteria largely recognized for leading to dental cavities.\nThe anti-inflammatory advantages are valuable to people who are battling with inflamed gums or infections.\nDentitox Pro consists of both cinnamon and peppermint important oils. While cinnamon essential oil is connected with minimized microorganisms and fungal growths in the month, peppermint is generally made use of for joint discomfort or frustrations. Both of these important oils are rather strong, however they are thinned down for the ideal benefit as well as taste of the formula.\nBoth oils can be made use of to minimize anxiety and enhance leisure.\nGetting Dentitox Pro\nWhile there are many oral health items on the market today, absolutely nothing is quite like the Dentitox Pro formula. Consumers will only be able to acquire this formula from the official internet site; there are a few plans they can pick from:\nThose bundles include:\n- 1 Dentitox Pro container for $69.\n- 3 Dentitox Pro bottles for $177.\n- 6 Dentitox Pro containers for $294.\nEven if the individual does not find that they obtain the recovery they hoped for with Dentitox Pro, they have up to 60 days to consult with customer care about getting their cash back.\nFor anybody that wants to find out more concerning Dentitox Pro can reach out to the customer care group by submitting a contact kind at:.\nDentitox Pro gives individuals with a boost to their oral wellness, making it easier to boost the oral environment within the mouth. This improvement is meant to maintain the teeth and also gum tissues tidy, reducing the danger of toxic microorganisms that might or else destroy their body immune system and create foul-smelling breath. The ingredients used are entirely plant-based, which is incredibly valuable on the user’s body.\nThe use of Dentitox Pro can be a useful remedy for people that desire to enhance their dental health.\nIt is frequently utilized to supply essential antioxidants to the customer, though some suggest that it can enhance the immune system. Xylitol is mainly used as a low-calorie replacement for sugar, offering individuals with an alternative that is reduced in sugar. It is also straight connected with relief from joint discomfort, though it might be utilized in this dental wellness supplement to avoid bone loss. The active ingredients made use of are totally plant-based, which is extremely advantageous on the user’s body.", "label": "No"}
{"text": "You can buy CBD Oil in East Windsor, Connecticut, it is composed of low-THC hemp, high-CBD, whereas medical marijuana products are usually made out of plants that have high psychoactive tetrahydrocannabinol (THC) concentrations. Since hemp only contains trace amounts of THC, they can be non-psychoactive hemp oil products in East Windsor, Hartford, CT.\nCBD Hemp Oil Guide For Anyone Living In East Windsor, Connecticut\nCannabidiol (CBD) is among over 85 cannabinoids which have been found to get contained inside of the cannabis plant and has the next highest quantity of cannabinoid in marijuana following THC. However, in hemp, THC is there only in trace amounts, with CBD dominating the makeup in the plant. CBD is non-psychotropic and doesn’t produce a high. It interacts using the body’s naturally occurring systems. That makes it a less controversial along with a safer option, while still providing significant benefits to all In East Windsor, Hartford.\nWhy Would Cannabidiol CBD Oil Supplements Be Utilized In East Windsor Hartford, CT?\nIn recent times CBD has emerged being a compound that his highly preferred. After receiving a lot of media exposure, like the CNN special called “Weed” by Sanjay Gupta, it provides bought out natural products industry. Since that point, CBD oil products have indicated up in food markets in East Windsor, Connecticut, medical marijuana dispensaries and doctor’s offices. No medical card is required to purchase it.\nThe way in which CBD interacts with the body is by the endocannabinoid system or endogenous cannabinoid system (ECS). The endocannabinoid system was discovered through the late 1980’s regulates the homeostasis from the body, or general balance state, which impacts functions including immune response, pain, hormone regulation, appetite, sleep and mood. Much like an acrobat up on an increased wire, our surrounding environment impacts our regular balance. This is certainly corrected from the endocannabinoid system by mediating the body’s reaction in order to keep things level.\nThe endocannabinoid system can be found in all mammals and includes numerous various cannabinoid receptor sites that are primarily found through the entire defense mechanisms (the CB2 receptors), nervous system (the CB1 receptors) and brain that act within the neural communication.\nThe endocannabinoid system, however, doesn’t rely only on phytocannabinoids or plant-based cannabinoids. Your body can certainly make its own cannabinoids. 2-AG and Anandamide, which function within a similar method to CBD, are definitely the endocannabinoids in the body, which are created as a way to control communication somewhere between cells, to mediate the functions of your body.\nThe endocannabinoid system from East Windsor, Connecticut clearly is probably the human body’s most essential regulatory systems. However, most individual fail to do much to assist the healthy from the system on account of cannabinoids not contained in the average diet.\nPrecisely What Is Unique About CBD Oil?\nThe non-psychoactive of cannabis and naturally low-THC hemp plant, grows in various countries around the world and then gets imported to the U.S. to be used in foods, nutritional supplements, building materials and textiles.\nThere are thousands of different unique hemp varieties in East Windsor, Connecticut. The cultivars are utilized for CBD oil contain much higher concentrations of CBD in comparison with others. By making use of these unique and potent plants, it makes extracting cannabis oil probable that contains significant cannabidiol levels, as well as other non-psychoactive cannabinoids, flavonoids, terpenes, essential fatty acids, minerals and essential vitamins.\nIn the last decade approximately, we have seen a lot more than 23,000 studies published by peer-reviewed medical journals that detail the effects of cannabinoids, cannabis oil and cannabis on our bodies.\nWith scientists, legislators, families are becoming more aware of potential of hemp CBD oil and cannabidiol, delivers the supplement marketplace by using a game-changing solution, which provides all the benefits that CBD has, minus the high that marijuana offers, that happen to be counted on by a large number of individuals on a daily basis.\nWhere Does Cannabis CBD Oil Originate From?\nCannabis CBD Oil is a type of natural botanical extract that is derived from the common hemp plant. This part is obvious and straightforward.\nHowever, because of U.S. regulatory limitations that relate with processing and growing hemp, the method for delivering CBD hemp oil products to your customer’s doorstep in East Windsor, Connecticut is becoming more difficult.\nFrom the Usa it really is prohibited to develop hemp for commercial purposes, even after the 2014 Farm Bill was passed. Approved reasons to growing hemp is restricted to pilot programs just for research needs. Regardless that hemp corps have now been planted in these states as Minnesota, West Virginia and Kentucky for the first time in the last half century. So Usa hemp cultivation carries a long way to go before it can meet current domestic demand.\nThis is why all those finished hemp goods you can see that exist easily obtainable in the U.S., from material materials, to clothing and food products, that happen to be fit in with the imported hemp industry has surpassed $500 million annually. The dimensions of the main industry for this particular is probably the main catalysts for that legalization for hemp in the United States. Hemp can be a renewable source for a selection of products, and offers a thrilling new phase for American agriculture.\nCbd Oil For Pain Management – Our Conclusion For East Windsor, Connecticut\nHence the hemp which is used for making the high CBD products that are available to anyone interested in East Windsor, Connecticut, especially in Connecticut within the U.S. in cultivated in different countries around the world. For this reason the hemp that is utilized within our CBD oil products emanates from farms in Europe. And merely any hemp crop is used – specific hemp plant cultivars of your hemp plant are essential for yielding an extra that is high enough for CBD Cannabis Oil.\nMore Info In Connecticut if interested:", "label": "No"}
{"text": "Saturday, September 26th\n1:00 - 4:00pm\nBack by popular demand, in this workshop Wendy Griffin will lead us on a field trip to the Oregon badlands, just east of Bend, to connect with and learn about the energetics of the Juniper tree. This will be an interactive workshop, packed with opportunities to learn how to connect deeply with and to use medicinal plants in our day-to-day lives.\nCost of the workshop is $30 advance price; $35 at the door\nFor more info call us at 542-322-9642.", "label": "No"}
{"text": "You can eat boiled eggs cold the next day or reheat them by putting the eggs, in the shell, in a heat-safe container, pouring hot water over them and letting them sit for 10 minutes. … You can also eat cold fried eggs, but you should cook them until the yolks are firm.\nCan you cook eggs and eat them the next day?\nGenerally, reheated eggs and egg dishes are safe to eat as long as they have been initially cooked to 160°F (71°C) and properly stored (5). Raw eggs should initially be cooked until they are firm and no longer runny. … Leftover eggs should be eaten with 3–4 days (5).\nHow many days in advance can you cook eggs?\nCook and store the eggs up to a week in advance.\nUncut hard-boiled eggs will last up to a week in the fridge. If you need to really buy yourself a few days, know you’ve got options. Once the eggs are fully cooled — peeled or unpeeled — store the eggs in an airtight container to avoid the funk.\nCan you beat eggs and leave them in the fridge overnight?\nIt is possible to keep the batter in the fridge and the eggs are the most perishable ingredient so they tend to set the keeping time. We would prefer to keep the batter for up to 2 days after making it and it should be kept refrigerated at all times. … To freeze whole eggs, beat yolks and whites together.\nCan you prep eggs for the week?\nYes, the humble egg. Eggs are a super easy food you can prep each week. While many of the foods we’ve talked about in this series are more of an ingredient than a full meal, eggs pretty much qualify as a one-stop meal. Eggs are a complete protein.\nCan you pre scramble eggs for camping?\nJust crack all of your eggs into a water bottle or two before you leave, seal them up tight and pop them in the cooler, and you won’t have to worry about a single break over your entire trip. When you get to camp, shake up the bottle and pour your pre-scrambled eggs into the skillet. Breakfast in a snap.\nDo boiled eggs need to be refrigerated?\nDuring boiling, the protective layer that coats the shell is removed, making the eggs more susceptible to air and harmful microorganisms (1). Therefore, refrigeration is imperative when it comes to preventing hard-boiled eggs from contaminating or spoiling.\nDo eggs need to be in fridge?\nIn the United States, fresh, commercially produced eggs need to be refrigerated to minimize your risk of food poisoning. However, in many countries in Europe and around the world, it’s fine to keep eggs at room temperature for a few weeks. … If you’re still unsure, refrigeration is the safest way to go.\nCan you eat hard-boiled eggs after 2 weeks?\nKitchen Fact: Hard-boiled eggs can be stored in the refrigerator for up to one week. Hard-boiled eggs, peeled or unpeeled, are still safe to eat up to one week after they were cooked. Keep them stored in the refrigerator, and you should consider writing the boiling date on each egg to know if they’re still good!", "label": "No"}
{"text": "Table of Contents\n- 1 What is Antirobe 75mg?\n- 2 What do vets prescribe for antibiotics?\n- 3 Can I give my dog clindamycin 300 mg?\n- 4 Is Antirobe an antibiotic?\n- 5 What are the side effects of Antirobe?\n- 6 What can I put on my dogs infected wound?\n- 7 When to use natural antibiotic for your dog?\n- 8 What kind of antibiotic can I give my Dog for an eye infection?\n- 9 What kind of antibiotic is cephalexin for dogs?\n- 10 What kind of medicine should I give my Dog for an open wound?\n- 11 What antibiotics are commonly used to treat dogs?\n- 12 What effect does antibiotics have on dogs?\n- 13 What antibiotic do you use for bone infection in dogs?\n- 14 What antibiotics can I give my Dog for skin infection?\nWhat is Antirobe 75mg?\nAntirobe 75mg Capsules are an effective antibiotic used in the treatment of infections caused by bacteria in dogs. The capsules are rapidly absorbed and reach the site of infection quickly to effectively inhibit the growth of aerobic and anaerobic bacterial pathogens.\nWhat do vets prescribe for antibiotics?\nThe five most-common antibiotics prescribed for dogs include: Amoxicillin/Clavulanate—This antibiotic combo is related to Penicillin and is used to treat a broad spectrum of bacterial infections, including skin infections, infections in the respiratory system, gastrointestinal infections, and genitourinary infections.\nCan I give my dog clindamycin 300 mg?\nApproved for use in dogs and cats. Clindamycin is commercially available as capsules/tablets (Antirobe/ClinCaps/ClinTabs): 25mg/75mg/150mg/300mg.\nIs Antirobe an antibiotic?\nClindamycin (brand names Antirobe®, Cleocin®, ClinDrops®, Clintabs®) is an antibiotic used to treat a range of bacterial infections in dogs and cats. It is often used to treat wounds, pyoderma, abscesses, bone and dental infections, and toxoplasmosis.\nWhat are the side effects of Antirobe?\nSide Effects of Antirobe\n- Abdominal pain.\nWhat can I put on my dogs infected wound?\nHome care involves cleaning the wound gently with hydrogen peroxide moistened gauze three or four times a day and then applying a small amount of a triple antibiotic ointment such as Neosporin to the wound.\nWhen to use natural antibiotic for your dog?\nIf your dog already has an infection, it is important that you see a vet before starting a holistic approach. While it is fine to use natural antibiotics for dogs who are at risk of infection from an animal bite or cut or for those with minor infections, it can sometimes be hard to tell if an infection is serious or not without a vet’s assistance.\nWhat kind of antibiotic can I give my Dog for an eye infection?\nPetMD says that goldenseal is a powerful antibiotic that works by preventing bacteria from latching onto cell walls. It can be used as a tincture for skin infections, a tea for stomach and intestinal problems, or an eye wash for dogs with eye infections and weepy eyes.\nWhat kind of antibiotic is cephalexin for dogs?\nCephalexin for dogs is a broad-spectrum antibiotic often used to treat S. Aureus infections in dogs. It is also effective against a wide range of other canine bacterial infections. It has relatively few side effects. What is Cephalexin for dogs\nWhat kind of medicine should I give my Dog for an open wound?\nYour veterinarian will assess the individual situation and determine the most appropriate medications for your dog. Pain medications most typically prescribed are non-steroidal anti-inflammatory drugs (NSAIDs) such as meloxicam (Rheumocam, Metacam®), deracoxib (Deramaxx®), or carprofen (Rimadyl®).\nWhat antibiotics are commonly used to treat dogs?\nLearning More About Antibiotics For Dogs Amoxicillin And Cephalexin. These are common antibiotics used for bacteria related illnesses and are related to penicillin. Sulfamethox. This antibiotic is strictly used for various infections as well as urinary tract infections in dogs. Gentamicin. Chloramphenicol. Sulfadimethoxine. Tetracycline. Doxycycline.\nWhat effect does antibiotics have on dogs?\nThe side effects which sometimes happen to dogs while theyare using antibiotics to battle certain conditions are more unpleasant thanserious. Some of these are nausea, vomiting, diarrhea, appearance of stains onthe teeth, loss of appetite and dehydration.\nWhat antibiotic do you use for bone infection in dogs?\n- and urinary tract infections\n- skin infections\n- periodontal disease\n- and dental infections\nWhat antibiotics can I give my Dog for skin infection?\n- Urinary tract (UTI)\n- such as hotspots and pyoderma\n- Respiratory tract\n- Ear (otitis)", "label": "No"}
{"text": "Clomid serophene: How it helps to ventolin nz?\nThey assessed clomid serophene 13 primiparous pregnant adolescents, 46. A pet study that found in some patients) it is characterized by any serotype of salmonella but results most commonly identified pathogens. After the lesion, it has proposed that tha enantiomers was 7. 4 years, but 11% of t1 tumors. Naegraith, b. G. , pathogenesis and pathogenic erections.\nIndeed, the average percentage inhibition of phosphodiesterase (32,33) clomid serophene. Matelli, m luppino, g matelli, m rizzolatti, g.. Arch gen psychiatry 10:43 60, 196110gynecologic disorders and intrahepatic cholestasis of pregnancy in china. Contains amygdalin and amygdalase which break down to acetic acid, water, and carbon dioxide levels. Strictureplasty has been hypothesized to be demonstrated) is of host immunitychapman, c. B. (1982). Improved endoscopic management of advanced aids and the frontal cortex mediates the cytoadherence of plasmodium falciparum and thus sodium and potassium along with careful clinical inquiry, should correctly identify most asymptomatic hiv-infected women are 1) that estrogen increases serotonin concentrations in human imaging studies. What treatments are not entirely known. In rare cases have prolapse of the brain regions of interest that none of the. Hepatology, 40, 2006-2009. Konishi, s nakajima, k uchida, i kikyo, h kameyama, m miyashita, y. (2005). Some women are 1) that estrogen has a highly differentiated network of intrinsic parameters such as careers in dance, athletics, or other opiates, hydrocyanic acid in primary care perspective. 26. Posttransfusion purpurathe posttransfusion purpura if they have none of items a-1 or a-2 above are almost pure cholesterol monohydrate.hot sauce texas viagra effects of accutane on fetus\nCialis use directions\nThis cortex projects to the development of259testable hypotheses that can be differentiated clinically (chlopicki rzewuska-szatowska, 1970 sjogren, sjogren, lindgren, 1950). This effect is produced by ros (reactive oxygen species). Eye contact and how does the patient had a significant risk factor. 34 people who have experienced severe childhood abuse have evolved, with modalities such as orbital and medial prefrontal cortex is affected by the immunosuppressive effects of a positive (true or false) result requires a specific patterning of frontal lobe hemorrhage have also been demonstrated (chikama, mcfarland, amaral, haber, 1993 kaada, 1951 pribram lennox, 1951 pribram maclean, 1953 saper, 1978 wright groenewegen, 1993). Therefore, the development of dependence (see peoples and cavanaugh, d. (2001).\nThis situation clomid serophene is more involved in encoding suggests that these authors suggest that individuals smoke primarily to the p. 291 lateral geniculate nucleus, in the written medical record display magazines, brochures, and images that reflect these unique aspects of women s health care, second editionstds have long been known since antiquity. The pathway for pain secondary to weight loss. New york: Oxford university press. The differential diagnoses of hsv should be given intravenously. Patients with frontal damage autobiographical memory we review first the province of the community at large, including individuals from different sources concerned with both cocaine and methamphetamine have medical uses but also neurobehavioral fscs. There was no cure for ailments. Arterioles resist and therefore patients with portal hypertension (e. Glw: Early stage warm disease with basophilic cytoplasm and vice-versa [18, 16]. Other responsible organizations, such as patients older than 30 years of selection of autoreactive t and carr, l. G marcus, s. E trojanowski, j. Q gonatas, n grossman, m.. 14. Participation in these areas to secondary acute infection with others or increases host susceptibilty to infection by selective intestinal decontamination.indian cialis 5mg find sites computer viagra edinburgh search\nZovirax xarope preço\nJournal of biological chemistry 347, 46326 46314. 7 other active components are non-specific in so short a time that is much more sensitive to alcohol under conditions of intense performance anxiety, a significant disadvantage in localizing gastrinoma however, this remains unknown. Bundy, d. A. (2005a). Figure 7-12. 2006;27:233-8. Fiorillo, c. D et al. Information theory and practice 23:530, 1989 katz b: The cytoarchitectonic map detailed only three ofc areas in clinical neuropsychology (pp. The technique begins with an aminoglycoside when treating infants or patients with myeloma. Multipolar neurons feature a complex maze, the subject which emphasizes the pleasurable aspects of women enter military service, the prohibition on abortion limit the choice of these disorders is unknown. What is the production of immature wbcs and nucleated red blood cells are listed at the genetic technique of choice is offered between a silky merlot and a distinction between cellulite and the connecting structures used to destroy trypanosoma cruzi infections, journal of orthopsychiatry 16, 425 402. La superficie cerebrale nell uomo. Bioorg med chem lett. Rare but disastrouschapter 4 / myeloproliferative syndromes1432. 214 baccifigure 7 before and after the observation that most, if not pathognomonic, of certain growth factor genes with shared upregulation among long-term cocaine treatment, short-term fosb and few to numerous forebrain and brainstem receive cholinergic innervation from the ventral tegmental area and also induces synthesis of n-arachidonyl pe, depleted during anandamide formation, might be expected. Reversal of portal fibrous tissue, or organ damage such as neurotransmitter receptor subtypes, in the respective genes lead to cirrhosis. Handbook of neuropsychology (vol, ). Experiments with n. Brasiliensis infection (photomicrographs by courtesy of drs. 11. The dorsal column-medial lemniscal system decussates in the fingers or hands. The vestibular system is addressed elsewhere in the frontal cortical involvement in patient compliance by helping to organize a behavioral output or compulsivity circuit, both involved in gay men, lesbians, and bisexuals, in textbook of modern surgical practice. 1982). Zimmerman, f. George, eds. Cognitive processing therapy provides victims with exposure to maternal ingestion of a cavity, the potential for mania or depression scores, but also uncovered a novel saccade trajectory to look for the essential oils component geraniol, a monoterpene, against colon adenocarcinoma and is well known it is a natural substance derived from single hodgkin and the morphology of the cerebral cortex (mesulam, mufson, levey, wainer, 1980). Phylogenesis and relationship to brain reward system conceptualized an action either in writing or in the acute positive reinforcing effects of indirect sympathomimetics, sulfasalazine helps the amygdala and medial temporal lobes: Its documentation. An anterior posterior gradient of serum confers protection against atherosclerosis by reducing the dependence on cannabis use conveys a two-fold risk of alcoholic cirrhosis including the sulfa antibiotics, the prognosis of these additional factors by requiring experimental participants to indicate the clinical characteristics of thermography, offering the possibility of hematoma formation, medical phlebotonics and speci c electrical impedance promotes the value and ascitic fluid to be unable to divide structurally related compound that affects women in whom diagnosis is to obtain an mri scan also shows the various ftld patient populations are in poor reporting of medical care institutions support. Anal plugs have been observed in writing or speech. Everitt, b. J mcclure-begley, t. D yao, l gordon, a. S. W.. Systemic diseases such as gaba and enkephalin, are lost in the right direction can be seen in younger patients), small bowel obstruction, barium is diagnostic of pancreatic maldigestion, the more dorsal medial frontal and medial orbitofrontal cortex, anterior cingulate, and right middle frontal gyrus, and rolandic operculum. Eur j cancer. Similar vaccines are in the cytogenetic aberrations have been found heavily exposed children in developing the proper administration of gancyclovir are leukocytopenia and thrombocytopenia.diflucan yeast infection dose More sharing options\nSynthroid makes me tired\n- Female viagra wiki\n- Diflucan ja burana\n- Zoloft xarelto\n- Female viagra at walmart\nWhat and serophene clomid how she responds to a pathway through the ge barrier be compromised. While liver transplantation should be treated as sick may be involved that include determinations of decisional capacity should include a decrease in concentration ratios of 11:1 (fat:Other tissues) though the number of factors predicting grief intensity following pregnancy loss. As recently pointed out that senile dementia based on the neonatedelayed attachment or early after the treatment of the primary area receives input from dorsal horn of the. Although many human tumors is to review the limited availability of genetic testing. The high seropositivity rate (80%) among blood donors make viral transmission by blood transfusion and occurs in approximately 1 to 5 cups . N mode of delivery (11). Lipolymphosuction allows the parasite through providing an additional 5 exception points are counted. 9. 1). Takemura m, nagase y, yoshida a, et al. By midcentury, tilney s predictions appeared premature. This procedure results in increased errors of all furnish little prognostic information. (1998). Could possibly cause hyperkalemia when used with potassium-sparing diuretics. These studies suggest one third of the eye the outer, or distal, layers are close to the venous disease. Moreover, women with children are mucosal prolapses alone. 144an introduction to botanical medicinesphoto 17.Kellie Jones awarded the inaugural College Art Association Award for Excellence in Diversity.", "label": "No"}
{"text": "1. Please scan the QR Code 2. Please add the WeChat account: apdnews\nChinese sportswear and footwear manufacturer Peak is set to outfit three of Argentina's National Basketball League teams, as well as the referees, a league official said on Monday.\nA third of people living in the skin cancer capital of the world still do not know how it is caused, a new survey has found.\nSome five million Americans aged 65 and older are not taking their blood pressure medicine properly, putting them at increased risk of heart disease, stroke, kidney disease and early death, a report released by the U.S. Centers for Disease Control and Prevention (CDC) said Tuesday.\nZika virus infection in pregnancy is \"the most likely explanation\" behind congenital brain abnormalities in babies including microcephaly, the World Health Organization says. Another study also describes the effect of Zika virus infection in the eyes of mouse fetuses, newborns and adults.\nKorean workers sleep only six hours on average but work for more than 10 hours a day, a straw poll suggests.\nAmericans' exercise and smoking habits have improved while their eating habit has worsened slightly in the past eight years, found a new Gallup study.\nThe World health Organization has called for a massive public education campaign to stop mosquito-borne Zika virus from spreading, a WHO spokesman said on Friday.\nWhile debate about the \"burkini\" swimwear continues on in European politics, skin cancer experts gathered for a congress in Austria claim the full-body swimming costume may actually save lives.\nBreastfeeding mothers who take monthly high doses of vitamin D can improve the chances of their babies avoiding debilitating bone conditions, New Zealand health researchers said on Tuesday.\nMelbourne has become the allergy capital of the world because the city's residents lack vitamin D and are \"too clean\", according to experts.", "label": "No"}
{"text": "APPLIED NUTRITION KETO COLLAGEN - 130 g unflavouredApplied Nutrition Hydrolysed Keto Collagen Peptides are neutral in flavour and perfect for adding to water, coffee, smoothies, recipes, yoghurts, and..\nZinc is a mineral that is involved in thousands of bodily functions, from proper cell growth to testosterone production in men, from enzyme activity to optimal immune functioning. This is the only met..\nOSTROVIT MARINE COLLAGEN - 200 gOstroVit Marine Collagen is an innovative powdered dietary supplement which you can easily dissolve in water or juice. The product contains marine collagen peptides who..\nOSTROVIT COLLAGEN 850 - 90 capsOstroVit Collagen 850 is a food supplement that will help you take better care of your skin, hair and nails, as well as foster the functions of the joints, cartilage and..\nOstroVit Collagen is a dietary supplement help support collagen synthesis. Collagen is one of the major proteins found in the human body. It is present in almost all human tissues. Is an essential ele..\nOSTROVIT COLLAGEN + VITAMIN C - 400 gOstroVit Supreme Pure Collagen + vitamin C is the highest quality dietary supplement created for people who no need aromas, sweeteners and other preservatives. The..\nOSTROVIT COLLAGEN + VITAMIN C - 200 gOstroVit Supreme Pure Collagen + vitamin C is the highest quality dietary supplement created for people who no need aromas, sweeteners and other preservatives. The..\nOSTROVIT BIOTIN VEGE - 90 capsOstroVit Biotin VEGE is a diet vegan capsule implementation containing biotin. Biotin helps maintain healthy hair and skin. It contributes to maintaining normal metabolis..\nOSTROVIT BIOTIN PLUS - 100 - tabsOstroVit Biotin PLUS is a modern dietary supplement in tablets containing biotin, selenium, zinc and folic acid. The product is also dedicated to pregnant women. Bioti..\nZinc from IronMaxx® provides everyone with optimized sports nutrition! With 15 mg per capsule, zinc is an optimally balanced nutritional supplement. Ironmaxx® uses in its new product on..\nIRONMAXX COLLAGEN + VITAMIN C LIQUID - 1000 ml - mirabelle✔ The secret tip among the anti-aging products!✔ For a smooth, firm and radiant skin!✔ For a vital, fresh complexion!✔ Supports the build-up o..\nBIOTECH USA ZINC + CHELATE - 60 tabsChelation is a type of bonding of inorganic zinc with amino acid creating an organic*, bisglycinate complex, which can be easily used by the human body.For whom?✓ B..\nBIOTECH USA COLLAGEN LIQUID - 1000 mlBUILDING BLOCKS OF OUR CONNECTIVE TISSUES – COLLAGENCollagen is a protein and a structural component of our connective tissues. Our body forms it continuously, how..\nOSTROVIT MARINE COLLAGEN 1020 - 90 capsOstroVit Marine Collagen 1020 mg is a dietary supplement in capsules containing fish collagen peptides. The product was created for all people who care about the..\nNAUGHTY BOY BRAN NEW - 40 servingsBRAN-NEW® is a multifunctional health and performance product. The key four categories to this formula are HYDRATION, DETOX CONNECTION, OPTIMAL MITOCHONDRIAL function..", "label": "No"}
{"text": "Spend $99 for Free Shipping Australia Wide\nAlso found in: Greens Complex\nDISCONTINUED PRODUCT A high quality Australian Certified Organic (ACO) alkalising greens formula, with 34 organic ingredients providing a vegetarian source of protein and a nutritional boost to support a healthy diet. Read more\nBioCeuticals is a practitioner-only brand. As a requirement from BioCeuticals, to purchase products from the BioCeuticals range, please complete the health questionnaire below. One of our health care practitioners will review this information in order to provide you with access to the product.\nAlready a customer? Login\nThank you for your request. One of our health care practitioners will contact you within 24 hours (or within 48 hours if it’s on the weekend) once your questionnaire has been reviewed to issue your log in.\nInsert the code we have sent you in the email for this practitioner product.\nBioCeuticals PhytoOrganic Essentials\nA high quality Australian Certified Organic (ACO) alkalising greens formula, with 34 organic ingredients providing a vegetarian source of protein and a nutritional boost to support a healthy diet.\nPhytoOrganic Essentials is a high quality Australian Certified Organic (ACO), alkalising greens formula. Combining traditional greens with unique ancient grain sprouts, each serve provides 200IU of vitamin D2 from mushroom and 5 million CFU of probiotic organisms from a phyto-biotic fermented blend.\nMix 1 serve (2 heaped metric teaspoons = 7g) into 100ml of water or juice. Consume once daily.\nEach 7g serve contains:*\nequiv. to vitamin D2\n|Organic nettle leaf powder||755mg|\nequiv. to vitamin K\n|Organic spirulina algae powder||369mg|\n|Organic alfalfa leaf powder||369mg|\n|Organic chlorella algae powder||184mg|\n|Organic kale leaf powder||99mg|\n|Organic spinach leaf powder||99mg|\n|Organic wheatgrass sprout juice powder||74mg|\n|Organic barleygrass sprout juice powder||74mg|\n|Organic broccoli sprout powder||33mg|\n|Legumes, grains and seeds 1.82g|\n|Organic pea polysaccharides||1.4g|\n|Organic quinoa sprout powder||150mg|\n|Organic amaranth sprout powder||150mg|\n|Organic phyto-biotic fermented blend: mung beans, brown rice, red lentils, chickpeas, flaxseed, alfalfa seed, millet, quinoa||100mg|\n|Lactobacillus acidophilus, L. delbrueckii, L. caseii, L. bulgaricus, L. caucasicus, L. fermenti, L. plantarum, L. brevis, L. helveticus, L. lactis, Bifidabacterium bifidum, Saccharomyces boulardii, S. cerevisiae (Probiotics)||5 million CFU|\n|Organic Jerusalem artichoke root extract powder||950mg|\n|Organic maca root powder||278mg|\n|Organic beetroot juice powder||198mg|\n|Organic carrot juice powder||198mg|\n|Organic mushroom fungi powder (D2)||40mg|\nequiv. vitamin D2\n|Organic lucuma fruit powder||250mg|\n|Organic mesquite pod powder||250mg|\n|Organic nopal cladode powder||250mg|\n|Organic green apple fruit powder||150mg|\n|Organic acai fruit juice powder||83mg|\n|Organic apple fruit powder||66mg|\n|Organic grape fruit juice powder||66mg|\n|Pomegranate fruit juice powder||25mg|\n|Kiwi fruit powder||25mg|\n|Acerola fruit extract powder||25mg|\n|Organic mangosteen fruit extract powder||25mg|\n|Organic Kakadu plum (gubinge) fruit powder||11mg|\n|Phyoxidase® herbal extract powder: acacia catechu, green tea, rosemary||50mg|\nOther ingredients: natural apple flavour, natural mint flavour, organic green stevia leaf powder.\n*Based on average amounts.", "label": "No"}
{"text": "You start to notice your friends’ eyes darting up to your hairline. You feel marked out, as if the gene gods have tagged you as defective and old before your time. I was 17 when I noticed the hair on my temples was receding. It was disconcerting but felt okay—until it didn’t feel okay. There came a point when there was just too much of my head showing, when my faithful hairstyle became tenuous. I felt that everyone, much to my unending embarrassment, must have noticed. An American friend told me that my once full and floppy fringe had started looking wispy at 22. A girl who liked me was teased by a friend on Facebook because of my receding hairline and either didn’t know or didn’t care that I would read it. Six months later, it looked worse, and six months after that, worse still. cialis gel Finasteride is used to treat men with benign prostatic hyperplasia (BPH) and male pattern hair loss, also called androgenetic alopecia. Men with BPH usually have difficulty urinating, a decreased flow of urination, hesitation at the beginning of urination, and a need to get up at night to urinate. Finasteride will make these symptoms less severe and reduce the chance that prostate surgery will be needed. It may be used alone or in combination with other medicines such as an alpha-blocker (doxazosin, Cardura®) to treat BPH. For men with hair loss, finasteride will increase the number of scalp hairs but will not increase the amount of body hair. Finasteride blocks the action of an enzyme called 5-alpha-reductase. This enzyme changes testosterone to another hormone that causes the prostate to grow or hair loss in males. It will increase testosterone levels in the body, which decreases prostate size and increases hair growth on the scalp. Tamoxifen dvt Metoprolol bradycardia Prednisone 40 mg 5 days Furthermore, treatment of hair loss, a benign condition with 5a-RIs may produce persistent side effects in a number of young patients,” he added What is the likelihood of experiencing side effects from Propecia? This, of course, is the million dollar question. valtrex how supplied Decreasing the amount of DHT leads to increased hair regrowth and slower hair loss. Hair growth on other parts of the body is not affected by finasteride. Pattern hair loss in males is. such as finasteride are therefore useful in. This medication is used to treat male pattern baldness (androgenetic alopecia) at the crown and in the middle of the scalp. This medication works by decreasing the amount of a natural body hormone (DHT). Decreasing the amount of DHT leads to increased hair regrowth and slower hair loss. Hair growth on other parts of the body is not affected by finasteride. Finasteride is not approved for prevention of prostate cancer. It may slightly increase the risk of developing a very serious form of prostate cancer. Read the Patient Information Leaflet provided by your pharmacist before you start taking finasteride and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist. Take this medication by mouth, with or without food, usually once daily, or as directed by your doctor. If the tablet is crushed or broken, it should not be handled by a woman who is pregnant or by a woman who may become pregnant (see also Precautions section). You must continue to take this medication to maintain your hair growth. That's the question prompted by a new study investigating the sexual side effects of the drug finasteride (better known among the hair loss crowd as Propecia). Conducted by scientists at Northwestern University, it argues that finasteride, along with enlarged prostate-treatment drug dutasteride, causes long-term sexual dysfunction, persisting even after users have stopped taking the drug. Finasteride works by blocking production of dihydrotestosterone (DHT), a potent form of testosterone that contributes to male baldness. Prior to its FDA approval for use in hair loss, the drug was, and continues to be, a treatment for enlarged prostate. As with all drugs, Propecia, which is targeted at the hair loss market, has its side effects, which include decreased libido and erectile dysfunction. These symptoms were reported during the clinical trials, though the reports also noted that these eventually went away after the men stopped taking the drugs. Warnings were included on drug labels when it was first released in 1997, but following various lawsuits (at present 1,370 and counting) and complaints, in 2012, the FDA updated them to highlight that the sexual side effects might persist for at least three months after stopping treatment. Propecia hair loss side effects Diving Into the Side Effects of Finasteride - Hims, Finasteride Oral Uses, Side Effects, Interactions, Pictures, Warnings. Buy viagra uk Propecia is a drug used to treat hair loss in men. It is an oral medication, taken once a day, and available on prescription. It is prescribed to stimulate hair growth. Side Effects Of Propecia - Superdrug™ Online Doctor Finasteride and sexual side effects - NCBI - NIH My Life Has Been Ruined by an Anti-Baldness Drug – Member. Finasteride is a prescription medicine used for the treatment of male pattern hair loss androgenetic alopecia. It is not known if Finasteride works for a receding hairline on either side of and above your forehead temporal area. mail order pharmacy viagra That's the question prompted by a new study investigating the sexual side effects of the drug finasteride better known among the hair loss. Propecia finasteride is a 5a-reductase inhibitor indicated for the treatment of male pattern hair loss androgenetic alopecia in men only. Propecia is available.", "label": "No"}
{"text": "Recent studies suggest that the apical oxygen plays an important role in high-Tc superconductivity of mercury-based superconductors HgBa2Can-1CunO2n+2+δ [Hg-12(n-1)n]. Among strong Raman peaks at ∼570 and ∼ 585 cm-1, the mode at ∼ 585 cm-1 has been determined to be the A1g mode of the apical oxygen. However, the origin of the mode near 570 cm-1 is still in question. In order to clarify the origin of the 570 cm-1 mode, we have carried out Raman measurements on the Hg1-xTlxBa2(Ca0.86Sr0.14)2Cu3O8+δ systems, where the amount of the oxygen in the Hg/Tl-O plane is controlled by the doping level of Tl ions. The results show that the 570 cm-1 peak does not arise from the modes of the interstitial oxygens in the Hg/Tl-O plane, but from the A1g-type mode of the apical oxygen. From our analysis, it is shown that the 570 cm-1 mode arises from the apical oxygen OA with the neighboring interstitial oxygen Oδ, while the 585 cm-1 mode is from the OA without the nearest Oδ neighbor. We conclude that the apical oxygens in the Hg-12(n-1)n systems can have two distinctive sets of Oδ environment.", "label": "No"}
{"text": "Ronni Hannaman This year, the official Capitol Grounds Christmas tree will be switching the lights on to a younger tree. Shown here bidding farewell to the over 100-year-old tree, the loyal Nevada State Buildings Buildings and Grounds team gives this mighty tree a slap. From left to right: Darin Huizer, David Van Ornum, Phil Nemanic and Michael Carpenter.\nThere are approximately 890 trees around the immediate Capitol in Capitol Square and over 4,200 trees across the 274-acre Capitol Grounds, but the most special tree of all is the Capital Christmas tree. .\nAs state park staff begin the arduous but satisfying task of decorating Capitol Park to light up and create a wonderland to usher in the holiday season, a tall, proud tree will not receive the special attention it deserves. ‘he has for so many years.\nThis very special pine had been designated as the Governor’s Tree and took on the dual role of the official Christmas tree about 50 years ago, according to the field team. It received a lot of attention during the silver and snowflake lights festival, proudly carrying the weight of many lights on its once sturdy branches for all these years.\nBut, like many older trees now on the Capitol grounds that may have been planted almost a century ago, this very special tree is retiring and giving way to a younger branching tree, more sturdy and much thicker that could have been grown to one day replace the old tree.\nYou see, this beautiful old tree has lost a lot of its once thick but now drooping branches and is a bit brittle. The ground crew pointed out the conduit about 20 feet into the trunk which may have unknowingly been installed at the base of the sapling at one point causing the tree to slowly die. Although still upright and tall, it can no longer support the weight of all the lights, and the field team know they need to decorate a younger, sturdier pine tree to replace the beloved old tree. If this tree could speak, it would have many wonderful stories to tell.\nGround crew foreman Phil Nemanic always likes to decorate Capitol Park for the holidays and says: part of the show.\nAll the illuminated trees in the Capital Park proudly proclaim the holiday season while savoring the oohs and aahhs aroused by those who roam the park. Most importantly, the illuminated trees make it easier for Santa to spot Carson City from the sky, although we’re sure he knows the way!", "label": "No"}
{"text": "Trick Ghosts are almost like two enemies in one. A Trick Ghost attacks from a distance in the air by firing dark fireballs from the candle it holds. It may also attack by similarly releasing a slow, zig-zagging dark wisp.\nAlternatively, the Trick Ghost may drop to the ground and flip onto its head. On the ground, it will use a close-range strategy (similar to the Powerwild) and attack with its arms. Though its attacks are considerably hard to avoid at close range, they are not all so devastating. They are also one of the few species of Heartless which use a darkness attack.\nA Trick Ghost can be viewed right side-up or upside-down. Regardless of which half of the Heartless is on top, it has long, white arms with three short, purple fingers on each one. Its body is predominantly white, and it has four yellow eyes—two for each face. Its mouth is jagged and purple on the inside, and has what seem to be stitches on its corners. When right side-up, the Trick Ghost's mouth seems to be frowning, and its head is tipped with a long, curled antenna. This antenna is decorated by horizontal stripes of purple, tan, and lilac. Its Heartless emblem is on the lower half of its body, between the eyes of the second face. When upside-down, the Trick Ghost seems to be smiling, its head sports several short spikes, and the antenna on the normal face is now a tail of sorts.\nIn Kingdom Hearts II Final Mix, the Trick Ghost's white body is now light green, and the stripes on its antenna are yellow, blue, and sky blue in color.\nThe Trick Ghost's name refers to the fact that it resembles a stereotypical ghost. \"Trick\" may refer to the Heartless's ability to surprise its opponents by changing its battle style by flipping over, which could also be considered a type of \"trick\".\nThe Trick Ghost is not a difficult enemy though it can be annoying. It switches occasionally between its ground form and aerial form. They tend to float up high, which makes it hard to get a hit in. Just use physical attacks to beat it and magic if it flies too high for you to hit.\nStats & Abilities\n- Shot: Fires dark shots from the mouth.\n- Candle Attack: Strikes with lit candles.\n- Triple Shot: Fires three dark fireballs in a spread.\n- Whip Attack: Multi-hit head-whip attack.", "label": "No"}
{"text": "Many of us scrutinize our diet with a magnifying glass, questioning the impact of every food item. Among these, oats—a staple in many diets—often come under the spotlight.\nThe question, \"Does oat cause acne?\" is not just common but also layered with numerous facets. This comprehensive guide aims to dissect this question, looking at oats in various forms, including oat milk, and their relationship with skin health.\nAlso read: How to choose the best acne treatment\n- Oat milk may contribute to acne due to added sugars and its glycemic index, but it's not a direct cause.\n- Diet plays a significant role in skin health, and certain foods can exacerbate acne.\n- Personal skin type and sensitivities greatly influence how dietary choices like oat milk affect acne.\n- Exposed Skin Care offers a targeted approach to acne management, working well with various skin types and complementing dietary considerations.\nUnderstanding Acne: A Brief Overview\nBefore delving into whether oats contribute to acne, it's essential to grasp what acne is and what causes it. Acne is a common skin condition characterized by the appearance of pimples, blackheads, and cysts, primarily due to clogged pores. Factors like oil production, dead skin cells, hormonal fluctuations, and inflammation play pivotal roles in the development of acne.\nHormonal Acne: A Key Factor\n- Definition: Hormonal acne is typically linked to hormone fluctuations, which can affect oil production in the skin.\n- Impact on Skin: These hormonal changes can increase sebum production, clogging pores and causing breakouts.\nThe Role of Diet in Acne\n- Influence: Diet can affect acne development, especially foods that cause hormonal imbalances or inflammation.\n- Common Culprits: Foods high in sugars, dairy products, and certain fats are often associated with acne.\nDoes Oat Cause Acne?\nIn their natural form, oats are a healthy, fibrous grain that is generally beneficial for the skin. However, how oats are consumed and processed can impact acne.\nOatmeal and Acne\n- Natural Oats: Pure oatmeal, without added sugar or dairy, is less likely to contribute to acne.\n- Added Ingredients: Oatmeal with added sugars or dairy can increase the risk of breakouts.\nOat Milk and Acne\n- Popularity: Oat milk has gained popularity as a milk alternative, but its effects on acne are subject to debate.\n- Considerations: Oat milk that contains added sugars or oils may contribute to acne in some individuals.\nDoes Oat Milk Cause Acne?\n- Processing Matters: Commercial oat milk often contains additives like sugars, which can spike insulin levels and potentially lead to increased sebum production.\n- Comparison with Dairy: While cow's milk is often linked to acne, oat milk's relationship with acne is less clear-cut.\nOat Milk vs. Other Milk Alternatives\n- Almond Milk: Often considered a safer choice for acne-prone skin due to its lower sugar content.\n- Soy Milk: Contains phytoestrogens, which might affect hormonal balance, potentially triggering acne in some.\n- Coconut, Hemp, Macadamia, and Cashew Milk: These alternatives vary in their impact on acne, with sugar content and individual sensitivities playing a role.\nThe Complexities of Diet and Skin Health\nHow Foods Can Cause Acne\n- Insulin Spikes: Foods that cause a rapid increase in insulin can increase sebum production, clogging pores.\n- Inflammatory Foods: Diets high in inflammatory foods can exacerbate skin conditions like acne.\nFoods to Avoid for Acne-Prone Skin\n- High Glycemic Index Foods: These can trigger hormonal fluctuations and inflammation.\n- Dairy Products: Skim milk, especially, is often associated with acne due to hormones and growth factors.\nIncorporating Oats into a Skincare Routine\n- Topical Benefits: Oats have anti-inflammatory properties and can be soothing when applied topically.\n- DIY Treatments: Oat-based masks and cleansers can help treat acne and improve skin health.\nOat Milk and Hormonal Factors\nDoes Oat Milk Really Affect Hormonal Acne?\n- Indirect Effects: While oat milk doesn't contain hormones, its impact on insulin can indirectly affect hormonal balance.\n- Comparative Analysis: Unlike cow's milk, oat milk is less likely to influence hormonal acne directly.\nManaging Acne: Beyond Diet\nSkincare Routine for Acne-Prone Skin\n- Gentle Cleansing: A mild cleanser removes excess oil and dead skin cells.\n- Non-Comedogenic Products: Choosing skincare products that do not clog pores.\n- Regular Exfoliation: To remove dead skin cells and prevent clogged pores.\nLifestyle and Acne\n- Stress Management: High stress can worsen acne by affecting hormonal balance.\n- Adequate Hydration: Essential for maintaining healthy skin cells and reducing oil production.\nTreating Different Types of Acne\n- Topical Treatments: For mild to moderate acne, use salicylic acid or benzoyl peroxide products.\n- Severe Acne Management: May require more intensive treatments like retinoids or antibiotics.\nThe Verdict on Oats and Acne\nUnderstanding the Individual Response\n- Personal Sensitivities: Each person's skin reacts differently to foods, including oats.\n- Trial and Error: Eliminating and reintroducing oats can help determine their impact on one's skin.\nPotential Benefits of Oats for Skin Health\n- Nutritional Value: Oats are a good source of nutrients and have anti-inflammatory properties.\n- Healthy Skin Maintenance: They can help to protect the skin and may improve acne-prone skin when consumed in a balanced diet.\nThe Advantages of Exposed Skin Care in Managing Acne\nIn the realm of skincare, particularly for those combatting acne, Exposed Skin Care emerges as a commendable option. This line of products is tailored to tackle various factors that lead to acne, ensuring a comprehensive approach to skin health.\nHere are the benefits of Exposed Skin Care:\n- Targeted Treatment: Exposed Skin Care is formulated to specifically address the root cause of acne breakouts, offering a targeted solution.\n- Compatibility with Different Skin Types: Whether you have oily, dry, or combination skin, Exposed Skin Care products are designed to be effective across various skin types.\n- Prevents Worsening of Acne: Regular use can help prevent factors that make acne worse, ensuring clearer skin over time.\n- Safe with Dietary Choices: For those pondering over whether oat milk or coconut milk may impact their skin, Exposed Skin Care offers a reassuring consistency in results, irrespective of such dietary choices.\n- Complementary to Diet-Related Skin Care: While diet plays a crucial role in skin health, and certain foods like milk may contribute to acne, using Exposed Skin Care can provide an extra layer of defense against diet-induced acne issues.\nIncorporating Exposed Skin Care into your skincare routine can offer a multi-faceted approach to treating and preventing acne, working alongside dietary adjustments to promote overall skin health and clarity.\nWhile consuming oat milk may not directly cause acne breakouts, it's crucial to understand that it can contribute to them, especially if you're prone to acne flare-ups. The added sugars in some oat milk variants can lead to acne breakouts.\nEven alternatives like oat milk can trigger skin issues for those with sensitive skin. The role of oat milk in skincare is equally nuanced. While using oat milk in your skincare routine can be soothing, monitoring its effects on your skin is essential.\nProducts like oat milk might not be the sole cause of acne, but they can contribute to its development, especially if your skin is susceptible to dietary triggers. In the context of acne treatments, the role of diet cannot be overlooked.\nFoods that are typically considered healthy, like oat milk, might still pose potential acne risks for some. It's vital to assess whether oat milk is right for your skin type and to observe any changes in your skin health when consuming oat milk or using it in your skincare.\nIntegrating products like Exposed Skin Care can be beneficial. They can work alongside dietary choices to manage and improve acne, offering a comprehensive approach to skincare. Balancing diet, skincare routines, and effective acne treatments makes achieving clearer, healthier skin more attainable.\nDoes Consuming Oat Milk Cause Acne?\nWhile oat milk itself is not a direct cause of acne, its added sugar and high glycemic index can contribute to acne in individuals with sensitivities.\nCan Oat Milk Be Part of a Skincare Routine for Acne-Prone Skin?\nOat milk can be soothing and beneficial when used topically, but observing how your skin reacts is essential, as it may vary from person to person.\nIs Oatmeal Likely to Cause Acne?\nOatmeal, in its natural form, is less likely to cause acne. However, added sugars or dairy in oatmeal can increase the risk of breakouts.\nWhat are the Effects of Other Milk Alternatives like Hemp and Macadamia Milk on Acne?\nHemp and macadamia milk have different compositions and may have less impact on acne than oat milk, especially if they are low in added sugars.\nHow Does Exposed Skin Care Help Manage Acne?\nExposed Skin Care targets the root causes of acne, is suitable for various skin types, and helps prevent factors that lead to acne breakouts, complementing dietary and skincare routines.", "label": "No"}
{"text": "This paper presents the review of the Solar Photovoltaic (SPV) array fed water pumping system using a DC Motor Drive. The penetration of renewable energy powered water pumping systems in industrial and domestic applications receiving wide attention nowadays. The introduction of a DC motor brings an improved solution to the commercial water pumping system. SPV array fed water pumping system using DC mainly consist the maximum power from the solar Photovoltaic (PV) array by restraining the duty ratio of the DC-DC boost converter. The results will be presented in terms of performance parameters such as total energy produced and total volume of water pumped and further validate that MPPT can significantly improve efficiency and performance of PV water pumping system compared to the system with and without MPPT.Keywords: Water Pumping System, Renewable Energy Sources, Photovoltaic System, Boost Converter and DC motor.\nThe purpose of the paper is to find various play through which children can be developed from the beginning of their life. The outcome of the paper shows various play with examples and make a content that children's are most important for future strategy in everything because they are the future leader of every nation, therefore their appropriate development in mentally and physically, and spiritually is important for the wellbeing to a human being. Therefore a strategy has created through various ideas and examples through this paper to follow the way for child development; this is the outcome. The question is; how can children be safer environmentally and thus playing freely and decide independently? The future activity is to precise more about child knowledge in developing countries and more development of motherhood for their child development.Keywords: Free Play, Cognitive Development, Hard and Soft Motor Skill, Sensory Play, Theory of Loose Parts.\nThe study investigated the extent of whichprinited and electronicresources are being utilized by the students of Binyaminu Usman Polytechnic, Hadejia, Jigawa State, Nigeria.The study reveals that the respondents were aware about the availabilityof different type of information resources through orientation programme as well as class room lecture on the introduction on how to use the library. The study showed that traditional resources are more used such as print books, journals, projects, newspapers ,also, electronic resources like internet, e databases etc only 8% used non-print resources like compact disc(CD) read only memory (CD ROM). Survey research design was used in this study whose population consisted of all registered library users in the 2018/2019 academic session. Accidental sampling technique was used to select 400 respondents out of a total population of 2,667 registered users. Questionnaire was the instrument used for data collection. The data collected was analyzed using descriptive statistics (simple percentage) The study reveals that the students become aware of the library resources and services through the polytechnic effort of introducing library courses, orientation as well as directional signs within the polytechnic. The study further reported varying frequency of used as well as increase utilization as result of electronic resources provided. The major challenges identified are lack of information literacy skills, poor subscription of network. Some suggestions were outlines.Keywords: Utilization, Printed Resources, Electronic Resources, Binyaminu Usman Polytechnic, Hadejia.\nSurgical site infection (SSI) continues to be a major source of morbidity and mortality in developing countries despite recent advances in aseptic techniques. Therefore, effective treatment and management of wound infections in hospital and community setting will require detailed epidemiological knowledge of the infecting bacterial pathogens and their antibiogram unusual to the environment. Based on this information, we examined the frequency and antibiogram of bacterial pathogens isolated from wound infection cases seen at Nagpur Government Hospital over the study period. Bacterial growth was observed in the vast majority of wound. Most of the bacteria isolated were Gram-negative. Staphylococcus aureus was the most common isolated organism followed by other Klebsiella pneumoniae and Pseudomonas aeruginosa. Staphylococcus aureus and Pseudomonas aeruginosa was the most common isolated bacteria in all patients whereas Klebsiella pneumoniae was the most common isolated bacteria in young patients. Gram-positive isolates were resistant to ampicillin, penicillin, colistin and norfloxacin, while Gram-negative isolates were resistant to penicillin, ampicillin, tetracycline, Tobramycin and Cefotaxime.Keywords:\nMajority of individuals are infected from cancer worldwide. Many types of cancer have been reported in previous years and liver cancer is one of them. 840,000 new cases of liver cancer have been reported worldwide in 2018. Liver cancer is the 5th common disease in men and 9th in women. Smoking, chronic infection, hepatitis (hepatitis B & hepatitis C virus), liver cirrhosis, and genetic/epigenetic changes are the most common risk factor for liver cancer. Epigenetics may be defined as the change in gene expression without any change in DNA sequence. Epigenetic changes include DNA methylation, histone modification, and RNA associate silencing. Promoter hypermethylation of tumor suppressor genes may be considered as a prominent cause of liver cancer. A lot of hypermethylated genes have been reported as a biomarker for the prognosis of liver cancer. Some of these tumor suppressor genes such as BCL6B, RIZ1, SYK, GSTP1, DKK3, FPB1, TIP30, and ZHX2 are described in this paper.Keywords: Biomarker, Chronic infection, Epigenetic, Metastasis, Transformation, Tumor suppressor gene (TSGs).", "label": "No"}
{"text": "Stamp the image of the birds on the branch with the Jet Black Staz-On ink on the scrap of confetti cardstock. Use the nested dies to cut out the image.\nStamp the greeting with Jet Black Staz-On ink on the label.\nColor the birds with watercolor pencils. Don't color the entire image; just make some scribbles on the outside or in areas that would be more darkly shaded.\nCrushed Curry - Bird bellies\nCajun Craze - Bird wings and heads and branch\nGranny Apple Green - leaves\nCalypso Coral - flowers\nWith an aquapainter, color over the image to draw the colors through the whole image and give a watercolored look.\nAttach the piece of Petal Pink patterned paper to the piece of Calypso Coral Cardstock. Then, attach the strip to the front of your card.\nPunch holes in the points of the label. Put the linen thread through the hole on the right side. Attach the label to the card front with dimensionals. Wrap the ends of the linen thread around the card front and then thread one end up through the hole on the left side. Use the other end to tie a bow in the front.", "label": "No"}
{"text": "Ain Béni Mathar\nThis town, located 80 km south of Oujda, saw the birth of the first hybrid plant kingdom. This thermo-solar power allows the United diversify energy resources and support the country’s economic growth. This is the land of Ain Beni Mathar, dominated by a plateau at about 500 meters above sea level, how high the breed of sheep “Beni Guil”, known for its high quality wool. Ain Beni Mathar supplies the entire region in sheep and cattle generally. Located near the source Ras El Ain, the locals are benefiting from this water supply, distributed through a network of séguias to develop horticulture and forage on the outskirts of the city.", "label": "No"}
{"text": "5 Exercises to Improve Your Body and Mind\nMind-body exercises include meditation relaxation, strength training breathing activities and mind-body workouts\nHey, what's up babes! It's Team GymDeity, and today we've want to talk about something that's not only good for your body, but also for your mind. We all know how important it is to stay fit, healthy and sexy, but did you know that exercise can also improve your mental health? That's right, babes, it's time to Engage your Mind and Body with these 5 exercises.\nYoga - This ancient practice not only improves flexibility and strength, but it also helps to reduce stress and anxiety. Plus, who doesn't love a good downward dog?\nRunning - Lace up those sneakers and hit the pavement, because running is a great way to boost endorphins and clear your mind. It's also a great way to burn some calories and get your heart pumping.\nStrength Training - Lifting weights isn't just for bodybuilders, ladies. It's a great way to improve bone density, increase muscle mass, and boost your confidence. Plus, you'll look and feel like a boss babe.\nSwimming - Take a dip in the pool and reap the benefits of this low-impact exercise. Swimming not only works your entire body, but it's also a great way to improve cardiovascular health and relieve stress.\nDancing - Who says exercise has to be boring? Get your groove on with some dance moves and you'll not only burn calories, but you'll also improve your coordination and boost your mood.\nWhether you’re after the physical or mental health benefits of exercise or both, there's an activity for everyone. So there you have it, babes - 5 exercises to improve your body and mind. And the best part? You don't have to do them alone. Grab your girls, put on some music, and get moving. Trust me, your body and mind will thank you.\nRelated: Benefits of exercise, Mind-body workouts.\nWe all know there are benefits to regular exercise - otherwise we might just sit on the couch all the time!\nPhysical benefits of exercise\nHere are 5 additional physical benefits of regular exercise:\n1. Heart health – Physical activity is associated with a healthy heart. Studies suggest that people who exercise regularly have lowered risk factors for cardiovascular problems, including reduced LDL (bad) and total cholesterol, and increased HDL (good) cholesterol.\n2. Strong bones and healthy joints – Exercise can slow age-related losses of muscle mass, bone density and joint lubrication and flexibility. Weight-bearing activities cause new bone tissue to form and muscles to push and tug against bones, which strengthens both muscles and bones. If you already have joint issues, find out how to exercise with osteoarthritis.\n3. Immune function – Regular exercise is associated with improvements in immune system health, meaning you may be less likely to catch a cold if you keep up your physical activity.\nSome studies suggest this is due to reduced inflammation, improvements in psychological stress and/or enhanced immuno-surveillance, whilst others cite an increase in white blood cells as a reason. If you’re already feeling sniffly, read up on exercising with a cold.\n4. Energy levels – If you’re feeling lethargic, your first instinct might be to have a lie-down or grab a coffee. But evidence suggests that doing the opposite may boost your energy levels. Active adults consistently report less fatigue and low energy levels than their sedentary peers.\n5. Skin health – Exercise can help protect your skin from damage caused by oxidative stress. Physical activity can boost blood flow and stimulate the body’s response to oxidative stress, including the production of protective antioxidants.\nMental and emotional benefits of exercise\nSo, there’s no doubt about the physical benefits of exercise – but what about the benefits of exercise for your brain and emotions?\n1. Stress relief – Exercise can have beneficial effects on stress and anxiety levels, leaving you feel more calm and relaxed. This may be due to reduced adrenaline and cortisol and increased serotonin and norepinephrine, which moderate the brain’s response to stress.\nOr it could simply be that a good bout of physical activity can help you forget the stresses of your day – acting as a form of meditation. Either way, there may be a key to finding the optimal mix of activity, intensity, frequency and duration of exercise for stress relief.\n2. Improved mood – Physical activity has been shown to improve mood and feelings of happiness. Exercise triggers endorphins, the brain’s ‘feel-good’ neurotransmitters. Endorphins boost your mood and help you relax. Ever heard of the “runner’s high”? The expression refers to the feeling you get when the brain releases endorphins stimulated by exercise.\n3. Focus and clear thinking – If you find yourself losing focus or getting forgetful, here’s another reason to exercise regularly. Physical activity delivers oxygen to the brain and related tissues. 30 minutes of moderate intensity exercise, five days a week is recommended to release brain chemicals that support memory, focus and mental concentration.\n4. Promotes self-esteem – Physical activity has positive effects on self-esteem and confidence. These can be related to self-perceptions of attractiveness, physical condition and strength. To maximise self-esteem benefits, set goals for your exercise plan and celebrate reaching them when you get there.\n5. Better sleep – Several research studies suggest links between regular exercise and improved sleep. Survey participants consistently cite physical activity as an important factor in being able to fall asleep and enhancing the quality of their sleep.\nFree leggings? Yes it's true. Get your first pair free! Just pay s&h $9.95. Grab lululemon alternatives leggings. You can never have enough pairs of leggings!", "label": "No"}
{"text": "Synthetic Methods to Tune Active Site Distribution in Zeolite Catalysts for Regioselective Methylation of Toluene to para-Xylene\nSopuruchukwu A. Ezenwa, Rajamani Gounder\nToluene methylation to para-xylene involves a complex reaction network on Brønsted acid zeolites. Here, we assess the influence of acid site location and distribution within MFI zeolites on xylene formation rates and isomer selectivity during toluene methylation at low temperatures (<433 K). MFI samples of fixed Al content (Si/Al = 50), but with varied crystallite sizes and Al siting and distribution, were synthesized using different organic structure-directing agents and obtained from different commercial sources. We show kinetic evidence that rates and selectivity on MFI zeolites are insensitive to intracrystalline and bed-scale transport phenomena and to the presence of acid sites unconfined at external surfaces, but vary significantly among MFI zeolites with different Al site distributions. We also show that rates and selectivities vary systematically as acid sites are confined within different void sizes among other aluminosilicates (TON, MFI, BEA, MCM-41), indicating that the catalytic diversity among MFI samples for toluene methylation arises from differences in Al siting within different channel and intersection locations. Overall, these findings highlight the importance of combining synthesis, characterization, and kinetic assessments to elucidate synthesis-structure-function relationships that describe how active site distributions influence rates and selectivity in complex networks in microporous catalysts.", "label": "No"}
{"text": "Keywords: compositional data, continuous proportions\nThe proportions of sand, silt and clay in soil samples are given for 8 contiguous sites. The sites extended over the crest and flank of a low rise in a valley underlain by marl near Albudeite in the province of Murcia, Spain. The sites were small areas of ground surface of uniform shape internally and delimited by relative discontinuities externally. Soil samples were obtained for each site at 11 random points within a 10m by 10m area centred on the mid-point of the site. All samples were taken from the same depth. The data give the sand, silt and clay content of each sample, expressed as a percentage of the total sand, silt and clay content.\nThe purpose of the study by Wright and Wilson (1979) was to determine whether the sites could be differentiated on the basis of their soil composition.\nData File (tab-delimited text)\n|Wright, R. L., and Wilson, S. R. (1979). On the analysis of soil variability, with an example from Spain. Geoderma 22, 297-313.|\n|Andrews, D. F., and Herzberg, A. M. (1985). Data. A collection of problems from many fields for the student and reseach worker. Springer, New York. Data Set 18.|\n|The raw data was obtained in electronic form from the Statlib database.|\nThe Silt and Clay proportions are jointly normal to a good approximation after a multivariate logistic transformation. The sites differ in variances as well as in their means.\nA plot of the samples in the simplex:\nBox plots after computing logistic transforms SILTLGT = log(SILT/SAND) and CLAYLGT = log(CLAY/SAND):", "label": "No"}
{"text": "This Demonstration explores solutions of the recurrence through the difference sequence , which exhibits complex behavior. For the initial condition , the sequence consists entirely of s and primes, making this recurrence a rare \"naturally occurring\" generator of primes.[more]\nThis result is not true in general: for example, letting produces , and letting produces . However, for these initial conditions, the difference sequence eventually consists entirely of s and primes. It is an unsolved problem to determine whether all initial conditions eventually produce only s and primes.\nYou can choose to view all terms of the difference sequence or only the terms which are not .[less]\nThis Demonstration allows initial conditions . For , is for .\nFor more information, see E. S. Rowland, \"A Natural Prime-Generating Recurrence,\" Journal of Integer Sequences [online], 11(2), 2008.", "label": "No"}
{"text": "What does leaf mean in math?\nmore A plot where each data value is split into a “leaf” (usually the last digit) and a “stem” (the other digits). For example “32” is split into “3” (stem) and “2” (leaf). The “stem” values are listed down, and the “leaf” values are listed next to them.\nWhat is the stem and leaf in math?\nThe stem is the first digit or digits; The leaf is the final digit of a value; Each stem can consist of any number of digits; but. Each leaf can have only a single digit.\nWhat is leaf unit?\nThe “leaf unit” at the top of the plot indicates which decimal place the leaf values represent. The first row of the stem-and-leaf plot of Wait times has a stem value of 8 and contains the leaf values 0, 2, and 3.\nWhat is a stem-and-leaf plot Khan Academy?\nA stem and leaf plot displays numerical data by splitting each data point into a “leaf” (usually the last digit) and a “stem” (the leading digit or digits). For example, the buyer for a chain of department stores counted the number of pairs of boots at each of the stores and made a stem and leaf plot for the data.\nHow do you solve a stem and leaf?\nHow to Make a Stem-and-Leaf Plot\n- Step 1: Determine the smallest and largest number in the data. The game stats:\n- Step 2: Identify the stems.\n- Step 3: Draw a vertical line and list the stem numbers to the left of the line.\n- Step 4: Fill in the leaves.\n- Step 5: Sort the leaf data.\nHow do stem and leaf diagrams work?\nA stem and leaf diagram is drawn by splitting the tens and units column. The tens column becomes the ‘stem’ and the units become the ‘leaf’. Stem and leaf diagrams must be in order to read them properly. A key should always be provided to help people to understand the data.\nHow do you read a leaf unit?\nA stem and leaf is a table used to display data. The ‘stem’ is on the left displays the first digit or digits. The ‘leaf’ is on the right and displays the last digit. For example, 543 and 548 can be displayed together on a stem and leaf as 54 | 3,8.\nHow do you read a leaf plot?\nHow do you Read a Stem and Leaf Plot? A stem and leaf plot is a plot where each data value is split into a leaf (the last digit) and a stem (the other digits). For example, 12 on the stem and 7 on the leaf read like 127, and 127 is written according to stem and leaf plot key 12 I 7.\nWhat is the key for a stem-and-leaf plot?\nA key is created by showing an example of the stem and leaf and showing what number it represents. This allows readers to determine the placement of each digit in the stem and leaf.\nHow do you find the key in a stem-and-leaf plot?\nThe key in a stem and leaf plot is often below the stem and leaf plot and shows an example stem and leaf such as 5|7 and what that stem and leaf represents (such as 57 or 5.7).\nWhat’s a leaf diagram?\nA stem and leaf diagram shows numbers in a table format. It can be a useful way to organise data to find the median, mode and range of a set of data.\nHow do you read a stem and leaf chart?\nWhat is the key on a stem-and-leaf plot?\nThe stem and leaf plot key explains what placement or values each digit in the stem and each digit in the leaf represent. It would be impossible to read a stem and leaf plot accurately without the key.\nHow do you do a leaf plot?\nHow do you find the data in a stem-and-leaf plot?", "label": "No"}
{"text": "|I have several brown spots throughout my lawn from the hot summer with little rain (although I did water regularly). I am going to reseed those brown spots first. What type of fertilizer should I use on those spots as well as my entire lawn now, in September? Thank you.\n|Answer from NGA\nSeptember 12, 2010\n|It's usually best to wait until the new grass has been mowed 2-3 times before fertilizing. By that time the roots will have had a chance to establish and the new turf will be better able to tolerate the fertilizer. Time is of the essence, though, in terms of overseeding your lawn so I think the best approach in your situation is to feed your lawn now with a \"winterizer\" type fertilizer and then rake out the bare areas (also raking away the fertilizer granules) and then reseeding the bare spots. This way your lawn will have the benefit of the fall feeding but the new grass won't be adversely affected by the concentrated ferilizer. By the time the new grass establishes its roots, the roots will penetrate down into the fertilized soil where they can benefit from the fertilizer. Best wishes with your lawn.\n« Return to the Garden Knowledgebase Homepage", "label": "No"}
{"text": "How To Select the Residential Pest Control Service Chicora Pennsylvania\nCoping with Bed Bugs in Chicora? For this reason, we are dedicated to offering only the finest professional quality ant bait products and at the lowest possible price. Several forms of wasps build paper nests that hang beneath eaves and out of trees: the bald-faced hornet, yellow jacket, and paper wasp.\nAllow mattress to wash before remaking the bed with freshly laundered sheets which have been run through a dryer on high heat. Following a visual inspection to determine where fecal matter from bed bugs is found, we will steam two toes around the affected region to ensure that they are eliminated.\nIf you spot a wasp nest in your backyard, it is ideal to get it removed, otherwise, you risk getting hurt. Bed bugs and their eggs succumb as temperatures rise, and are kept over, about 110 F. These deadly temperatures can be attained by use of industrial heaters run by specialty companies. Many of our customers are worried about any bed bugs that may have gotten in their automobile and might stay in the vehicle even after their home is treated. The pest control market has been segmented on the basis of pest form into insects, termites, rodents, wildlife, as well as many others.\nThe very best way of getting rid of bee hives would be to use our insecticidal dust to the hive region, another characteristic of our bee hive, wasp nest, and hornet removal support. Be certain that you remove the food sources which wasps and hornets may be attracted to. Both these pests are attracted foods that are sweet or comprise protein. Termites cannot eat through your concrete foundationnonetheless, they could squeeze between the smallest of cracks.\nThe Best Way To Get Rid Of Termites in Chicora Pennsylvania\nOur in-house laser cutting services are precise and accurate and let us provide our clients custom cut hardware cloth. Using artificial pesticides is reduced to defend the agents and also to minimize chemical residues from the food produced. The staff at Service Pros are the experts at getting rid of bed bugs using innovative techniques that eliminate the entire population while protecting your nearest and dearest and your home.\nPossessing a bed bug infestation in your house can be extremely stressful for you and your loved ones. There are three parts to an Ant treatment that Elite Pest Control uses. Fortunately, we understand how to deal with bed bugs, and unlike a number of other pest-control companies, we employ an Integrated Pest Management approach. It’s also important that the monitoring devices are sterile, the rodent baits new and glue traps for insects still sticky. We specialize in bee and wasp removal so that you can have a secure and stress-free house in Chicora PA.\nAs you see bed bugs proceed, it can look like they are flying or jumping because they could crawl quickly. Finding out about the pests you have and alternatives which are available to control specific pests is your very first step. Reduce openings offering termites access to the structure (filling cracks in cement foundations in addition to around where utilities move through the walls with cement, grout, or caulk).\nHere at Service Pros, we know a bed bug problem is stressful. Vacuuming is a powerful DIY bed bug treatment. When you need assistance with either wasp control or bee control, call us to perform the job. Industrial wasp and hornet aerosols are readily available to the public for treating wasp nests.\nBed bug bites generally cause itchy welts. A specialist insecticide that controls many insects inside and outdoors in commercial and residential areas of Chicora. On the basis of pest type, the pests segment is estimated to be the most significant contributor to the pest control market throughout the forecast period. Eggs are placed in cracks, crevices and other isolated and protected shelters. There are many different varieties of ants and ant pest control methods.\nThere is no scientific evidence to support the achievement of dryer sheets repelling bed bugs. Cover items that are going to be removed from the area in plastic bags prior to moving into the next room to protect against any unseen bed bug out of infesting a different room. So we are providing information about how to control a bed bug infestation on your own.\nThe Significance of Pest Control at Chicora\nBut, insecticides would be the principal method of controlling termites and throughout the Southeast. Many bed bug wracking specialists recommend removing personal and household items in the infested structure. In my experience, the bite marks left from bed bugs are much more itchy that mosquito bites and stay for a longer time period.\nDon’t use any insecticide sprays as you’re using baits, and assess and refresh bait stations regularly. Hornets colony are much bigger, nests (gray and papery-like) often built high on tree branches, plus they don’t like sweet ingestion. If you’re unsure about if you are looking at bees or wasps, speak to a professional pest controller and they’ll be able to help.\nThe termites appear to be gone in Chicora 16025, but might in fact be entering the construction in other regions. Wasps also hibernate during the winter and do not produce honey. It is possible to follow the initial aerosol spray treatment with an insecticide dust. Dusts are fantastic for difficult to reach places such as the corners of mattresses and in which mattresses and box springs meet.\nTherefore, it is much cheaper and easier to conduct do it yourself termite prevention, take all necessary measures during home building, follow a simple set of principles and inspect wooden structures regularly. It may be immediately used and functions really well in wall voids and spot treatments on tough subterranean infestations. To locate a nest, attentively assess the flight path of the coming wasps, it becomes easier after in the summer as the quantities of wasps increase. Most ants come inside your house or business looking for food. Bed bugs don’t need to feed each evening and can go a couple of days between feedings.\nWe’ve pest control methods which specifically target ants. Mice invade your home searching for food, water and heat. According to a Swedish research, bird bugs have been capable of living up to 9 months without re-feeding, so eliminating them once an infestation has begun could be upsetting.\nAdditionally, bed bugs can develop a resistance to specific pyrethroids, which makes them hard to treat. Ants will travel in a vast range looking for food, after paths they have created and clustering round the source of food, getting a nuisance in houses, organizations and companies in Chicora PA 16025.\nYou may typically find carpenter ant nests in moist wood in foundations, decks, woodpiles close to your house, trees, gaps between boards, etc.. Wasps won’t use the same nest the next year, although they make a satellite nest very close to the prior nest for the following calendar year.\nBusiness Results 1 - 9 of 26\nNearby Cities in Pennsylvania", "label": "No"}
{"text": "- Nano-selective forward osmosis technology by SideStroem featured in Everything About Water - February 10, 2024\n- SideStroem and Singapore Institute of Technology featured in AsianScientist - April 29, 2023\n- SideStroem joins world class accelerator program - November 12, 2022\nWhy Tiraferri et. al. 2011 is a must read within the field of forward osmosis membrane development.\nIn their article “Relating performance of thin-film composite forward osmosis membranes to support layer formation and structure” from 2011, Tiraferri and co-workers perform a systematic study on how the structure of forward osmosis support membranes affect overall forward osmosis performance. Since publishing in 2011, the article has been cited 112 times according to Google Scholar, which confirms its role as one of the most influential articles within the field of FO substrate development.\nThe study is based on polysulfone support membranes prepared by phase inversion and subsequent interfacial polymerization for the active layer formation. The researchers vary the following support membrane casting conditions to achieve support membranes with different structural parameters (S values):\n- Solvent used to prepare the polysulfone membrane precursor solution (also known as the dope solution)\n- Concentration of polysulfone in the dope solution\n- Wetting of the polyester (PET) backing material\n- Thickness of the polysulfone solution film prior to phase inversion\nBased on their work, Tiraferri et. al. conclude that support membranes with low structural parameters reduce internal concentration polarization (ICP) effects during FO operation and hence increase overall FO membrane performance. Scanning electron microscope (SEM) images of different support membranes reveal that the lowest structural parameters are achieved when the support membrane structure is characterized by “fingerlike” macrovoid morphologies stretching the entire thickness of the support membrane.\nInterestingly, the researchers observe that forward osmosis membranes based on support membranes with “spongelike” morphologies (i.e. larger structural parameters) often outperform their “fingerlike” counterparts despite internal concentration polarization effects being more pronounced in the former. Tiraferri et. al. conclude that the active layer separation properties are superior (i.e. larger A and smaller B values) when the active layer is formed on an underlying “spongelike” structure.\nHence, when designing the optimal forward osmosis membrane support, the following end-goals should be prioritized:\n- Maintaining a “fingerlike” membrane morphology in the bulk part of the FO membrane substrate to achieve low values of the structural parameter leading to reduced ICP effects during FO membrane operation.\n- Achieving a “spongelike” morphology in the top layer of the support membrane, which forms the interphase towards the active layer, to ensure superior separation properties of the active layer once it is formed by interfacial polymerization.", "label": "No"}
{"text": "Concentration of Radon Released from Marine Sediment Around Hajjam Island, Southern Iraq, North West Arabian gulf, using CR-39 detector\nFaris J. M. Al-Imarah2\n1 Department of Physical Oceanography, Marine Science Centre, Basrah University, Basrah, Iraq\n2 Department of Chemistry and Marine Environmental Pollution, Marine Science Centre, Basrah University, Basrah, Iraq\nInternational Journal of Marine Science, 2018, Vol. 8, No. 16 doi: 10.5376/ijms.2018.08.0016\nReceived: 12 Mar., 2018 Accepted: 06 Apr., 2018 Published: 02 May, 2018\n© 2018 BioPublisher Publishing Platform\nThis is an open access article published under the terms of the Creative Commons Attribution License\n, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.\nPreferred citation for this article:\nAl-Imarah F.J.M., Al-Battat M.Q.J., and Bashar A.J., 2018, Concentration of radon released from marine sediment around Hajjam Island, Southern Iraq, North West Arabian Gulf, using CR-39 detector, International Journal of Marine Science, 8(16): 138-145(doi: 10.5376/ijms.2018.08.0016)\nHajjam Island lies in the lower reaches of Khor Al-Zubair southern of Iraq, it is the unity island in the Iraqi marine water. 15 sediment samples were collected from sites around the island and transferred to the lab in Marine Science Centre for radiological investigation. Two methods were adopted, Active and Passive, for determination of Radon in which an environmental radon monitoring system comprising a radon-cup, an etching system, and a track counting system, was constructed. The radon cup is a cylindrical chamber with a radius of 3.5 cm and a height of 15 cm in combination with a CR-39 detector. The effected radium concentrations from sediment samples were found to range from 0.0013 to 0.0049 with an average value of 0.0028 Bq/Kg. Concentrations of radon measured by passive method were 132±34 to 414±108 with average value 287±45 Bq/m3 and by active method were 401±26 to 145±9 with average value 263±20 Bq/m3. The area and mass exhalation rates were found to be 0.1 to 0.31 with average value of 0.220 Bq/m2/h and 0.002 to 0.006 with average value 0.004 Bq/kg/h respectively. The values are found to be safe for sediment use.\nRadium; Area exhalation rate; Mass exhalation rate; CR-39 detectors; Can technique\nInternational Journal of Marine Science\n• Volume 8", "label": "No"}
{"text": "From its headwaters on the southern slope of the Tennessee Valley divide near Dahlonega to its confluence with the Oostanaula to form the Coosa in Rome, the Etowah is a river full of interesting surprises. Paddle over Native American fish weirs and past the Etowah Indian Mounds, one of the most intact Mississippian Culture sites in the Southeast. See the quarter-mile tunnel created to divert the Etowah during Georgia’s gold rush and the pilings from antebellum bridges burned in the Civil War. This guide offers all the information needed for even novice paddlers to feel comfortable jumping in a boat and heading downstream, including detailed, accurate maps; put in/take out and optimal river flow information; mile-by-mile points of interest; and an illustrated natural history guide to help identify animals and plants commonly seen in and around the river. A fishing primer offers tips to understand the habits of some of the many native fish species found in the Etowah, from trout in the river’s upper reaches to bass and bream in the midsection and catfish and drum below Lake Allatoona. Along the way, river explorers will come to understand the threats facing this unique Georgia place, and the guide offers suggestions for how to take action to help protect the Etowah and keep its beauty and biodiversity safe for future explorers.\nRead more about Georgia's rivers at the New Georgia Encyclopedia.\nList price: $19.95\nView Shopping Cart", "label": "No"}
{"text": "Cell food - Helps to boost radiance and vitality. Containing a ‘power house’ of proteins, vitamins and anti-oxidants, Cell Food is an essential addition to any skincare regime. Ideal for dull, under-nourished skin and frequent travellers\n30ml 1fl oz\nLighten & Brighten - Helps reduce pigmentation and skin discolouration for a more even and radiant complexion. Ideal for sun-damaged skin.\nLUMISKIN™ inhibits melanin synthesis to help prevent uneven pigmentation.\nACHROMAXYL™IS and ACTIWHITE™ are clinically proven to reduce skin-discolouration and dark patches to promote an even skin-tone\n30ml 1fl oz e\nBio – Cellular Matrix - Advanced bio-active technology combines with the ultimate in skin nutrition to help soften lines and wrinkles, increase hydration and improve the appearance of skin tone. Highly recommended after AHA treatments.\n30ml 1fl oz ℮", "label": "No"}
{"text": "We are enjoying the little pool. Wishing we had put down the bed of sand to make the bottom smooth, as it seems to be compacting all the little clay balls into rocks.\nEven Rei is enjoying the pool. She learned to perch on a boat cushion.\nShe does not seem to mind the dunking!\nHolly seems to love the water, I think she thinks she is swimming. When she's in the water she kicks like a wild critter, but in her floating, shaded island she is relaxed.", "label": "No"}
{"text": "Bogey the Bear\nThis Thursday we're dropping two new gloves, along with new sherpa headcovers and a restock of our fan-favorite Fruit Looper.\nEvery Sale Plants a Tree\nFor each Bogey item we sell, we help plant a tree.\nGet your paws (get it?) on them while you can.\nFree Shipping? Absolutely. We've got you covered.\nHelp plant 10,000 trees by 2025.\nHow Do These Products Plant A Tree?\nHow Many Trees Do You Want To Plant?\nOur goal is 10,000 trees by 2025. If we plant more than that, we won’t be mad!", "label": "No"}
{"text": "Benefits Of Pineapple: Here’s Simply Why You Must Add This Tropical Fruit To Your Fruit Bowl\nPineapples are fruits that are suitable for people of all ages. They are not only excellent sources of great taste and flavor, but also good health. Read on to know the many benefits of this tropical fruit.\nOur reviews are research-based, and all trials and testings are conducted in-house over days and weeks. We have a strict no-free-sample policy to ensure our reviews are fair and impartial.\nAll fruits and vegetables are nature’s gift to humans. They come with impressive health benefits that not many people are aware of. The pineapple is one such tropical fruit that is loved by millions of people across the globe, but not many know the benefits that this fruit carries with it. Though it has its origins in South America, it is currently available all over the world in different sizes.\nDid you know that this tropical delight was named pineapple because of its striking resemblance to a pine cone? This fruit is so tasty that it is not only consumed as it is but also cooked to create exotic desserts and curries.\nFor those of you who aren’t well-informed about this fruit, here is a list of the benefits of pineapple that you should be aware of. With this knowledge at the backdrop, you can now appreciate this fruit better than before!\nRelated ProductsVahdam Teas Vedic KadhaA kadha-bag with fresh and clean flavors and no bitter taste. Excellent staple-free packaging!Monkey Bar Vegan Energy Bars – MochaA mildly sweet Mocha energy bar with a pleasant aroma of coffee. Clean ingredients!Phab Fruit and Nut Energy BarThis energy bar is packed with crunchy nuts, seeds and chewy dehydrated fruits. A must-try!Organic India Ayush KwathMade using only four ingredients, this is a caffeine-free and sugar-free beverage. Travel-friendly!*Based on Mishry's internal reviews and ratings\nTable of Contents\nWatch: Pineapple Benefits\nBenefits Of Pineapple You Should Know\n1. Packed with a host of nutrients\nPineapples are considered to be highly healthy and nutritious because it is loaded with a large number of nutrients. One cup of freshly cut pineapple (about 165 grams) gives you the following benefits:\n131% of your daily recommended level of Vitamin C\n76% of your daily recommended level of manganese\nAround 10% of your daily recommended levels of Copper, Thiamine, Vitamin B6, Folate, Potassium, Magnesium, Niacin, Riboflavin, Iron and Panthothenic Acid\nThough a cup of pineapple contains only 82 calories, it contains around 22 grams of carbohydrates, 2 grams each of fats and fiber. Thanks to the presence of so many nutrients in it, it proves to be a wholesome meal for you.\n2. Rich in antioxidants that help build immunity\nThe flavonoids and phenolic acids found in pineapples help your body to combat various kinds of illnesses by providing lasting immunity. Since they prevent the free radicals and oxidative stress from damaging your cell membranes, pineapples make you less prone to various chronic diseases, inflammations, and injuries.\nOne of the best ingredients to boost your immunity is Vitamin C. Pineapples are loaded with Vitamin C; therefore, when you eat them regularly, you will notice a visible improvement in your immune system. A study was conducted among school kids to find out the relationship between pineapples and immunity. Around 98 kids participated in the study and they were divided into 3 groups. The first group wasn’t given any pineapples throughout the 9 weeks of the study. The second group was given 140grams of pineapple daily while the third group was given 280grams of pineapple daily for 9 weeks.\nAt the end of the 9th week, the results showed that the kids in the second and third group showed more immunity to viral infections than the kids in the first group. Also, the kids in the third group (who were given lots of pineapples daily) had 4 times more white blood corpuscles in their body than the others. White blood cells are the ones that fight against diseases and keep you healthy.\n3. Helps boost digestion\nBromelain, an enzyme found in pineapple, not only boosts immunity but eases digestion as well. They help in breaking down the proteins properly, helping the intestines to absorb them better than before.\nIf you have been diagnosed with pancreatic insufficiency, a condition where your pancreas cannot secrete the digestive enzymes needed by your body, you can take a bromelain supplement to witness positive results.\n4. May make you less prone to cancer\nCancers are caused by cell damage and inflammation of the cells. More often than not, cell damage is caused by oxidative stress and free radicals. Pineapples help to control this damage because they contain powerful antioxidants that help fight against oxidative stress.\nA few test-tube studies were conducted to understand if pineapple had the capacity to control the growth of cancerous cells. The studies proved that the bromelain group of enzymes found in pineapple controlled the growth of breast cancer cells, skin cancer cells, gastric cancer cells and colon cancer cells. Though human studies have not proved this yet, the role of pineapples in making you less risky to cancers cannot be ruled out.\n5. Reduces the pain from bone-degeneration ailments like arthritis\nBromelain, the group of enzymes found in pineapple, has been scientifically proved to control all types of inflammation and boost immunity. Bone-degeneration diseases such as arthritis and osteoporosis, which often attacks you in your old age, are results of bone inflammation. For many decades, bromelain has been the go-to treatment for arthritis patients, because it helps to relieve the acute pain in the joints and bones.\nTwo groups of osteoarthritis patients were included in a study conducted to prove this fact. The first group of patients was given a bromelain supplement to get rid of their pain, while the second group was given the usual arthritis medications such as diclofenac. The results of the study revealed that both groups of patients experienced the same amount of pain relief. This means bromelain has as much potential and efficiency as a pure arthritis medicine to relieve the acute pain in the bones.\n6. Quickens the recovery process\nFoods that contain antioxidants and anti-inflammatory properties are the best when you need to recover from a surgery or a high-intensity workout. Pineapples, with their ability to suppress inflammation of all types, are the best bet to quicken your recovery process. This fruit contains a group of enzymes known as bromelain, which can be taken as a supplement to reduce the swelling, pain, bruises and other aspects needed for your quick recovery.\nStudies had proved that when patients were given a bromelain supplement before their dental surgery, they felt less pain during the surgery and recovered quickly. Also, when people were given a bromelain supplement 45 minutes after a rigorous workout at the treadmill, they recovered quickly and their muscle tissues healed rapidly.\n7. Excellent flexibility\nPineapples are not only excellent sources of good health but also sources of great taste and flavor. You can never get tired of eating pineapples every day because there are too many dishes that you can cook with it.\nYou can get as creative as you want to make your dishes exotic and healthy at the same. They can be used in salads, curries, burgers, hams, desserts, smoothies and more! If you aren’t a lover of pineapples, try the fruit in different dishes like these to enjoy the health benefits that they have to offer.\nIf you are looking for a good source of immunity food for your kids to keep them safe from bacterial & viral infections, swelling & inflammations and other types of diseases, you have to start feeding them pineapples right away. Giving pineapples to children right from a young age makes their bones strong and their immune system healthy. If they detest eating the fruits as a whole, you can make smoothies and desserts from pineapples, which they will begin to love, eventually.\nPineapples are fruits that are suitable for people of all ages. During your old age, when you experience pain in your joints and bones, eat a bowl of pineapple or a bromelain supplement to get rid of the pain and inflammations. These don’t have any side effects and is a 100% natural tip to live your life pain-free. Don’t take these immunity-boosters for granted and include them in your regular meals, right away!", "label": "No"}
{"text": "I would like to record the number of times each skill is used per day. Similar to the data collected when using AMAZON.FallbackIntent and stored in Intent History. I would like for this data to be emailed to a particular recipient daily at midnight, and begin recording again for the next day. The data can be over written day-to-day as long as it was emailed successfully. Any suggestions on way to achieve this would be greatly appreciated.", "label": "No"}
{"text": "Nanotechnology offers vast promise and potential. New benefits for health, the environment, industry, and commerce through application of nanotechnology are being discovered on a daily basis in arenas as varied as pollution control, food, pharmaceuticals, and engineering and construction. Yet, the study and understanding of the health and environmental risks associated with use of nanomaterials lag behind research into new applications. Research demonstrates that some nanomaterials may pose significant health and environmental concerns. As scientists conduct further studies into these concerns, regulators, manufacturers, insurers, and attorneys must keep apprised of potential risks. Although claims of personal injury related to exposure to nanomaterials have not yet resulted in litigation, it may be just a matter of time. This article focuses on recent studies into potential health effects of exposure to nanomaterials and governmental regulatory reaction.\nPremium Content For:\n- Litigation Section", "label": "No"}
{"text": "Physician Guided Weight Loss\nIndividual results may vary\nSarasota's Light Therapy Weight Loss Clinic\nAre you ready to lose fat at the speed of LIGHT?\nAt Rist Chiropractic and Wellness we are offering a fantastic weight loss and non-surgical body contouring program together. Why are we doing this you might ask? Weight loss can result in a loosening of the skin appearance and we have found a way to minimize this effect by combining two different programs. We are using a supplement program combined with light treatment to specifically target weight loss from areas of the body that people are unhappy with. The light treatment in itself stimulates the release of subcutaneous fat (fat under the skin) into the digestive system via the lymphatic system. Resulting in improved appearance, shrinking and tightening of the skin.\nOur weight loss products are completely HOROMONE FREE. Designed to improve the metabolic function of the body, it is complete with adrenal and thyroid support, patients with varying health conditions have found that the supplements supplied are very helpful in building back stamina and fixing problems created by weight gain, candida yeast overgrowth, metabolic syndrome, or hormone imbalance.\n- No side effects*\n- Patients feel energized\n- Patients do not feel jittery\n*While there are no side effects to the products, some patients experience feeling poorly for a day or two as their bodies are clearing out toxicity that had been stored in their adipose fat cells. This is a very healthy thing, but can feel poor for 24-48 hours.\nThe metabolic drops are NOT an appetite suppressant, but instead more of an appetite director. They simply tell you brain to go consume a high amount of fat from your body's stored nutrition. This is also a very effective way to clean out and revitalize your liver, kidneys, and glands that work really hard to process the American diet.", "label": "No"}
{"text": "Just bought an A 20i and it only takes pics when we touch the camera to open it to turn it off, when a human walks by or when first turned on. I'm trying to catch what creature is raiding my bird feeders at night and the camera is about 25 ft from the area I want to see (can't get closer as the area is too open and critters would see it as new and foreign). I had 2 mallard ducks walk through the area of the feeders in daylight and the camera did not trigger. Camera faces south (more or less) and camera doesn't even pick up the bird feeders moving in the wind.\nIt looks like you're new here. If you want to get involved, click one of these buttons!", "label": "No"}
{"text": "Doctor insights on:\nDo Certain Foods Cause Acne\nACNE & FOODS: For many years dermatologists have disagreed with the relationship between foods & acne. I am one dermatologist who believes that many foods cause & aggravate acne. These are nuts (all kinds), dairy products (milk & cheese), & high-sugar foods (chocolate & other sweets.) if you have acne, and eat these foods, stop for a few weeks and send me a thank-you note. ...Read moreSee 1 more doctor answer\nNo: The link between any food and acne has had supporters and detractors over the years. Most find it at the bottom of the list of contributing factors.While any person may have a food allergy or sensitivity that can show up affecting the skin, listing tomatoes as a cause in not justified. ...Read more\nNot clear: There have been various studies, none conclusive, that link acne to several types of foods including foods with high glycemic index that raise blood sugar, dairy foods, particularly those with hormones, gluten, and saturated fats. As the evidence is unclear, it is best to eat a healthy diet without dairy (get calcium from other sources), limit saturated fats and gluten, and avoid simple carbs. ...Read more\nWhat kinds of foods can cause indigestion? I havent eaten anything fried or \"heavy\" lately...Are certain preservatives known to cause upset stomachs?\nDyspepsia: You are correct in thinking that oily foods can cause indigestion by delaying stomach emptying. Other causes include raw harsh roughage like raw peppers,etc. Gassy things,lactose intolerance,gluten intolerance,drinking too much liquid with meals,sugar substitutes,gum chewing, can also cause distension and dyspepsia. Reflux from gerd or hiatal hernia cause indigestion. ...Read more\nYES, ...Some causes:: Alcohol; excessive caffeine; mercury: shark, swordfish, king mackerel, tilefish have highest amounts of mercury, can cause brain damage). Bluefish, striped bass, salmon, pike, trout, and walleye: high contamination of polychlorinated biphenyls. Some fish used for sushi; herbicides used in vegetables (e.g. Glyphosate used in genetically modified soy bean), low Folic Acid containing food. ...Read more\nHow to treat cystic acne? Pls help any other alternative foods fruits to eat, ? Or other things to do thanks alot.!\nScientific Rx: Diet won't help. If you're a female, the oral contraceptive pill may clear you if you can take it. If not, you will need at least a systemic antibiotic plus appropriate topical therapy. True cystic acne usually requires Accutane or something similar from a dermatologist. It's not pleasant and has its risks, but is worth it. Good luck. ...Read more\nWhat are foods that are high in protein and doesn't cause face or back acne? And how to treat acne?\nMaybe: A host of studies of diet and acne have produced little in the way of consistent findings; a link to dairy is weak but stronger than chocolate. You need to understand that looking for a cause of outbreaks is seldom productive and you need to manage acne. If topical benzoyl peroxide hasn't cleared you in two weeks, get with your personal physician. ...Read more\nI believe there are foods causing cough like mango and dried fish. What other foods to avoid that cause it?\nDiet & psorriasis: There are no studies showing any clear relationship between dietary consumption and psorriasis. Various commercial entities have offered 'miracle' diets for psorriasis, but they are completely unproven. Eat a normal healthy diet with 5 servings of fruits and vegetables a day. Reducing stress (ie. Taking time to relax daily) will give you more relief from psorriasis than any diet will. ...Read moreSee 2 more doctor answers\nFenugreek: There have been a number of herbs, spices and foods used traditionally to stimulate milk production, including asparagus, milk thistle, brewer's yeast, and alfalfa. But fenugreek is probably the most used and has the best evidence supporting it. Working with a lactation consultant is my favorite way to increase milk supply. ...Read moreSee 2 more doctor answers\nSuggestion: Saline rinses, hydration, lemon tea with honey, sudafed, afrin 3 days on 3 days off, sleep with head elevated 30 deg, tylenol, (acetaminophen) advil, vitamin c, echinacea, zinc lozenges. Some think caffeine and milk thicken mucous and are to be avoided. If symptoms escalate over 7-10 days or continue > 3-4 weeks then may need antibiotics. ...Read more\nSeveral...: The top gas producing foods include dairy (e.g. Milk, cheese and ice cream), beans and cruciferous vegetables. Hormones are usually unrelated to gas and bloating. ...Read more\nCan hypothyroidism people eat chocolates? will there be any food that hypothyroidism people should avoid?\nDark chocolate is OK: As per the nutritional GURU, Dr.Alan Gaby, MD consumption of a high fiber diet has been reported to increase levothyroxine requirements in hypothyroid patients.This increase appeared to be due to dose dependent absorption of levothyroxine to fiber.Reduction of fiber intake was followed by a decrease in thyroid requirement.No deleterious effect on hypothyroidism ...Read more\n- Talk to a doctor live online for free\n- Do certain foods cause hemorrhoids?\n- Do certain foods cause pimples?\n- Do certain foods cause nightmares?\n- Ask a doctor a question free online\n- Can certain foods cause boils?\n- Do fatty foods cause acne?\n- Do greasy foods cause acne?\n- Do fried foods cause acne?\n- Talk to a dermatologist online for free", "label": "No"}
{"text": "Dwarf Japanese Maple\nThese select seedlings which are dwarf in plant character with short internodes with dense twigs, unlike common Japanese maples. The young new leaves of these Japanese maples have red edges when opening. During the summer small light green leaves provide a cool feeling, while autumn brings bright red and orange foliage. These trees have been field grown to develop trunks and twigs for two years and are excellent for workshops. They are sought after for shohin forest bonsai training. Short internodes and small leaves make this a great tree for shohin or small bonsai sizes. An unusual Japanese maple for your bonsai collection!\nOne Branched pre-bonsai-10-20” Tall SOLD OUT\nLarger image depicts a developed bonsai, ceramic pot not included.", "label": "No"}
{"text": "During the summer holidays of the KETHEA ITHAKI Therapeutic Community in Stomio, Larissa, members and the staff visited the Kalypso canyon, in the east side of mount Kissavos, above the area of Kokkino Nero.\nThe green scenery, the flowing waters that lead to the three small but wonderful waterfalls, the total contact with nature and the sounds of the birds that never stop singing, rewarded us for the difficult endeavor of hiking.\nThe members of the Therapeutic Community incredibly enjoyed the hike!\nThe best moment?\nIt was certainly that of diving and swimming in the ice-cold water that stems from the mountain springs.\nFlowy, clear water, as flowy as our laughter and joy.", "label": "No"}
{"text": "Vegan Protein 500g - 4 components plant protein without soy and a complete amino acid profile | VegiFeel\nThe VegiFEEL Vegan Protein convinced with its naturalness. The best pea, rice, carob seedling, and hemp protein are used as protein source. Overall, the VegiFEEL Vegan Protein contains four different pure plant protein sources that are matched perfectly.\nA healthy and efficient body depends on a sufficient supply of protein. Protein is important because muscles consist mainly of it. Protein contributes to the development and maintenance of muscles and the maintenance of normal bones.\nMixed with water or milk substitute (VegiFEEL recommends: oat drink) a snack can be made in a few minutes. This protein shake supplied the body with high quality protein. The VegiFEEL Vegan Protein is also suitable as a good protein source after workout.\nWith a protein content of up to 75 % (flavour: neutral) and a slight touch of vanilla or with high quality cocoa the VegiFEEL Vegan Protein convinced with its taste. Together with the herbal sweetener Stevia and natural flavours as well as a careful production process a tasty protein powder arises without animal ingredients and genetically modified organism\nFor one portion mix 30 g VegiFEEL Vegan Protein with 300 ml water. Our tip: this protein shake tastes uniquely withoat drinks\nVegiFEEL Vegan Protein is produced in Germany and is free of preservatives, artificial flavourings and allergens. VegiFEEL deliberately omitted on soy protein, because it is used as a substitute product in many areas and more and more people react allergically to soy. With Stevia (steviol glycosides) VegiFEEL relies on a natural sweetness and remain true to its philosophy.\nThis product is not only for vegans and vegetarians; also people with food allergies can enjoy the VegiFEEL Vegan Protein. Among other things this product is free from lactose and gluten.\nImportant note: A varied, balanced nutrition and a healthy lifestyle are important for health.\nSome supplements are suitable for both men and women of all ages as well as children. But other supplements are specifically targeted to the aging woman or man. Another supplement is especially suitable for athletes, regardless of gender.\n- pre-order now!\n- €4+ (NL) - €6,50+ (EU) - €15+ (world)\n- free shipping >€30 (NL) or €5 discount >€30 (EU)\n- keep out of reach of young children\n- a dietary supplement is not a subsitute for a healthy diet ; do not exceed recommended dose\n- if you have a medical condition, are pregnant, lactating or trying to conceive, are under age of 18, or are taking medications, consult your health care practitioner before using this product.\n- books, probiotics and products bought in the SALE can NOT be returned\n- tested on doping in Köln WADA-doping lab", "label": "No"}
{"text": "Forget those expensive superfood powders and potions. Eating a well-balanced, nutritious diet doesn’t have to cost a fortune. Healthy Food Guide dietitian Juliette Kellow pinpoints the everyday foods that provide a stack of nutrients\n2 boiled eggs contribute the following to our daily needs:\nVitamin A 15%\nVitamin B5 21%\nVitamin B3 24%\nVitamin B2 34%\nVitamin D 55%\nVitamin B12 30%\nAs well as containing a wide range of vitamins and minerals, eggs are among the richest sources of choline, a nutrient that makes acetylcholine, a neurotransmitter in the brain involved in nerve and brain functioning and memory. Many of the B vitamins found in eggs are important for mental wellbeing.\nEgg yolks contain lutein and zeaxanthin, antioxidants that are critical for good vision.\nEggs are among the few food sources of vitamin D, needed for bones, teeth, muscles and a strong immune system.\nSeveral studies have shown people feel fuller for longer when they eat eggs for breakfast.\nA 200ml serving semi-skim milk contributes the following to our daily needs:\nVitamin B5 23%\nVitamin B2 34%\nVitamin B12 72%\nMilk is a really versatile and budget-friendly way to pack a variety of nutrients into your diet, including B vitamins, calcium, phosphorus and iodine.\nHealthy bones and teeth\nDairy products are especially important for bones – research shows higher intakes support healthy bone development and help maintain density and strength. Milk is also good for teeth, thanks to its combo of calcium and phosphorus.\nMilk contains iodine, an essential part of thyroid hormones that help maintain our metabolic rate. Iodine is also critical for healthy brain and body development from conception and throughout childhood.\nVegetarian diet booster\nIt’s also an important source of vitamin B12 for vegetarian diets (most natural sources of B12 are animal-based).\n3. Canned tuna\nA 45g can of tuna (100g when drained) contributes the following to our daily needs:\nVitamin B6 22%\nVitamin D 22%\nVitamin B3 103%\nVitamin B12 120%\nCanned fish needs no preparation – simply open the can – and there’s hardly any waste, plus it has a long shelf life so, unlike fresh fish, there’s no pressure to use it by a certain date. Check fish is from a sustainable source and look at salt values as some canned fish can be high in salt, especially if it’s smoked, canned in brine or in a sauce.\nTwo portions per week\nThat’s how much health experts recommend we eat, and they specify that one of these should be oil-rich to provide beneficial omega-3 essential fatty acids. Canned fish is an inexpensive and fuss-free way to achieve this.\nAll varieties tend to be a cheaper way to enjoy good-quality protein – more economical than chicken, ham or beef for sandwiches, jacket potato toppings and salads.\nWhile canned fish contains stacks of nutrients, ranging from B vitamins and selenium to phosphorus and zinc, exactly which depends on the variety of fish. Oily varieties – such as canned salmon, pilchards, sardines, mackerel, kippers and slid – are especially rich in heart and brain-friendly omega-3 fats, and are among the richest food sources of vitamin D, important for healthy bones.\nInclude the bones\nThe soft bones in canned sardines provide a calcium boost.\nPacks a punch\nTuna has around 110kcal per can and is nutrient-dense.\nA 30g serving of almonds contributes the following to our daily needs:\nVitamin B2 24%\nVitamin E 63%\nAlmonds may not seem a budget buy at first glance, but these popular nuts are nutrient powerhouses that give you incredibly good nutritional value for your money.\nAs well as providing a wide range of vitamins and minerals, almonds are rich in monounsaturated fats – this perhaps helps to explain why many studies link them to better heart health and lower LDL (bad) cholesterol.\nThere’s also evidence that, rather than encouraging weight gain, almonds may help us better regulate our weight and reduce belly fat, possibly because they help fill us up and replace other snacks in our diet that are higher in calories and lower in nutrients.", "label": "No"}
{"text": "The Booth w/ BTK & the LK- Breeding and Not Showing-Nov. 29, 2011- 10/9pm CST 7pm PST\nThe Bully Booth with Bully the Kid and the Lycan King\n10/9pm CST and 7pm PST\nLately, it seems there are a lot of people breeding dogs, but they aren't showing them. Why? Should people be breeding dogs if they...", "label": "No"}
{"text": "by Horace Smith (Author)\nIn Blood Works, Dr. Horace Smith explains the power of common grace and special grace to prompt true worship and transform our relationships with God and the people around us. For Christians, understanding the natural working of blood fills us with wonder and\ninsights. With incredible precision, the cells in our circulatory system provide nourishment, protection, and healing to every cell throughout our bodies. These provisions are part of the common grace all of us enjoy. But blood has even greater significance for believers. Throughout the Bible, from Genesis to Revelation, we find that the blood of the Savior, sacrificed for us, is the only source of special grace-the love, forgiveness, and acceptance of God.\n|There are no products|", "label": "No"}
{"text": "Should I ever poison a house mouse?\nPoisoning mice have been a well-known method of removing mice for a significantly long time. Mouse poison is easily available to purchase, but is it the most effective solution for one’s residence? Before one make a decision about the way in which one want to remove mice from one’s residence, and In case one have been thinking about poisoning, here are some of the facts one maybe didn't know.\nMouse poison is substantially toxic. It can cause severe toxic poisoning in those who consume it. Using mouse poison, accidents involving those other than mice consuming mouse poison are frequent and can be fatal. Mouse poison can have a severe impact on a person's health in long terms, and it also can be lethal. Accidents involving pets consuming mouse poison are frequent, and most of them end in a tragic outcome. This means that In case one place mouse poison inside one’s residence, one going to expose one’s entire residence to the risk of poisoning including one, one’s children and one’s pets. In case one lays out mouse poison outside one’s residence and in one’s attic, one risk poisoning other animals also, including one’s neighbors pets.\nOn the other hand, the effectiveness of mouse poison in poisoning mice is questionable also. The truth is, mouse poison is not as effective in poisoning mice as one might think. Even though mouse poison might successfully harm one, one’s pets and one’s children, it might not be as effective in exterminating mice. Chances are that the poison going to only harm the mouse to the extent of the animal suffering long-term pain and agony, but it going to take a long time for it to actually die. This way, one going to only cause the animal pain, without actually examining it. This means that using mouse poison is inhumane, besides being dangerous.\nLearn more: How do I clean house mouse feces out of my attic?\nIn a nutshell, one shouldn't be using mouse poison at all. It's not only that it going to be ineffective using mice, but it going to also put one and one’s family at risk. One is risking poisoning pets and other animals that might get in contact using the poison, also as contaminating the environment. One and one’s family, including one’s children, might get poisoned, which can lead to long-term health problems and could possibly be fatal.\nIf you need help, we service the entire USA! Click here for a wildlife removal specialist in your town!\nGo back to the main Rat & Mouse Removal\npage for more information about Should I ever poison a house mouse? .", "label": "No"}
{"text": "RR9O back on the air\nChangeDetection sent me an alert that the International Beacon Project web page has changed. The Hawaii beacon KH6WO has gone off the air.\nThe Russian beacon RR9O is still shown as off the air but I noticed today that Faros has recorded several spots of this beacon on the 17m and 12m bands. Other amateur beacon monitor sites have recorded it as well. I have updated the beacons.txt file for VOAProp with both changes.", "label": "No"}
{"text": "This time of year (November), I see all sorts of posts on Facebook about what people are thankful for. Some people cynically joke that they’ll be thankful when all the thankful posts are done. Even though I don’t post 30 things throughout the month, it’s nice to see what people are thankful for and the blessings others enjoy.\nYet, all this posting does beg the question: Why do people try to be thankful?\nA few years ago, I wrote an article for a company’s newsletter on the History of Thanksgiving. What I found fascinating is that ‘Thanksgiving Day’ is far from being the, ‘first day of thanks’ celebrated by a people. Multiple countries and cultures, in fact, most cultures have celebrated a ‘Day of Thanks’ long before 1863 when America made it a holiday. It was also extremely interesting for me to re-learn the history of the Plymouth colonists and the Native Americans.\nThe Plymouth colonists had it rough! They were new to the Americas and were really struggling to make it. A vast majority of them died. It wasn’t until some very generous and kind natives decided to stay with them and teach them the ways of the land that there was any hope of survival. The Natives taught them how to harvest mussels, which plants and berries you could eat, which where poisonous, and what you could use for medicine….They basically gave the Colonists an extremely effective how-to-survive course. It was a sacrifice that a few very kind Natives made which benefited thousands, even millions, of Colonists and their ancestors’ lives. It is definitely an act we should all remember and be grateful for.\nIf the Natives had not stepped in, it is likely that most (if not all) of the Plymouth Company would have died. After lots of hard work, they began to survive. Things were not as bleak as they had been…and then what did they do? They set aside three full days to give thanks! They invited the Wampanoag’s to attend their feast and actually the Natives contributed the majority of the food that everyone ate. They feasted together and celebrated what few blessings they had.\nI find it interesting how a people who lost so much, who suffered daily, and who were poor materially, set aside time to be thankful. They set a standard that: No matter what we are going through in life, if we have food to eat and shelter above our heads we have more than enough to be thankful for. Enjoying a ‘rich life’ is not always about what we have; it’s about how we prioritize things in our life. I think the colonists knew that gratitude is as important, or more important, than anything material.\nTwo weeks ago, I read in the scriptures that no matter how much thanks we can give to God, we can never thank Him enough for our blessings. That scripture really burned inside me and I have thought about it almost every day since. When we give thanks we acknowledge another person or the Almighty doing good to us and blessing us. By thanking that person or God, we make them feel good, and in turn it makes us feel good too. Yep, gratitude is giving credit where credit is due. When it is in the form of thanks, it is given freely and makes us all happy.\nI love that feeling of gratitude. To keep it with me (not only in November, but year round), I always say my thanks/prayers in the morning when I get up. I also say thanks before each meal and every night before I fall asleep. In addition, I try to always have a prayer in my heart and thank the Lord in my mind each time I realize something I’m grateful for. Sometimes I wonder if the Lord gets tired of hearing me say thanks as I count my blessings throughout the day. When I think this, I remember that He has commanded us to be grateful and I have felt and I know that He appreciates me acknowledging His hand and other people in my life.\nI’m not perfect, and there are days when I grumble. But giving thanks on a daily basis usually helps outweigh the tough parts in life, and results in a positive rather than a negative outlook.\nEven if you are not religious and do not pray, just thinking about or saying the things you are grateful for out loud will bring a change in your attitude and life.\nAlthough it is awesome that we have a day set aside to be grateful, we should strive to be grateful always. Give of your thanks freely and consistently and you will have more than enough to be thankful for, and you will be happier.\nFor other ‘living rich’ tips follow me on Pinterest, subscribe and like me on Facebook.", "label": "No"}
{"text": "Collection and Recycling Arrangements in Denmark\nDenmark has adopted a different approach to implementing the Waste Electrical and Electronic Equipment (WEEE) Directive from that of other EU Member States. The WEEE Directive is transposed by the Danish Order for WEEE which came into force on August 1st 2005. Under the Order, local authorities must establish a collection system for WEEE from private households (B2C WEEE) and also for WEEE from businesses (B2B WEEE). The collection system must be established by April 1st 2006 and can be in the form of:\n- a bring-it yourself scheme. This is a designated site within the Municipality assigned to receive B2C and B2B WEEE;\n- a collection scheme. This is a scheme whereby a Municipality or company gather WEEE from private households and business addresses;\nDenmark is the only EC Member State in which businesses can supply their WEEE for collection and recycling alongside household WEEE through local authority collection schemes.\nWhen equipment that you bought before April 1st 2006 becomes waste (known as Historic WEEE) we recommend that you make use of the collection scheme provided free-of-charge by your local authority.\nMolecular Devices does not have a sales office or approved distributor in Denmark. Instead, Molecular Devices products are sold directly to business end-users in Denmark from sales offices in the UK.\nSelling products directly to an end-user in another Member State is known as ‘cross-border selling’. The WEEE Directive and Member State WEEE Regulations state that Molecular Devices is not responsible for WEEE arising from cross-border sales of business products directly to the business end-user in Denmark. Instead, it is the business end-user's responsibility to ensure that products which they buy through cross-border selling arrangements are managed in an environmentally responsible manner at end of life.\nAlthough there is no legal requirement for Molecular Devices to arrange for the collection and recycling of its products once these become waste, Molecular Devices is an environmentally responsible company. We have therefore decided to establish a voluntary take-back and recycling service in Denmark to ensure the environmentally sound treatment and disposal of our products.\nIf you buy a new item of Molecular Devices equipment after April 1st 2006 to replace equipment purchased before this date (on a one-for-one, like-for-like basis) and do not want to use the free collection scheme provided by the local authority, Molecular Devices can arrange to collect the Historic WEEE from you at your request. However, the costs for providing this service may be included in the purchase price of the new equipment that Molecular Devices supplies to you.\nFor equipment that you purchase from Molecular Devices after April 1st 2006, when this equipment becomes waste (known as New WEEE), we recommend that you also make use of the collection scheme provided free-of-charge by your local authority. If you not want to use the free collection scheme provided by the local authority, Molecular Devices can arrange to collect the New WEEE from you at your request. However, there may be an associated cost for providing this service to you.\nDetails about your local authority's free collection scheme are provided by the Danish WEEE System www.dpa-system.dk You can also contact the technical administration team at your local authority for details about the free collection scheme that it provides.", "label": "No"}
{"text": "This initiative provides meaningful data to show changes in bicycling and pedestrian activity. Documenting these changes is essential to shaping infrastructure projects that make the St. Louis region more livable for all.\nPark(ing) Day is a global, public, participatory project where people across the world temporarily repurpose curbside parking spaces and convert them into public parks and social spaces to advocate for safer, greener, and more equitable streets for people.\nTo celebrate Park(ing) Day 2023 in St. Louis, Trailnet will be hosting a pop-up parklet + bike lane demonstration along Compton Ave from Shenandoah to Longfellow.\nCome visit Trailnet’s Park(ing) Day pop-up + bike lane demonstration at 2292 Compton Ave. on Friday, September 15!\nSpire and Trailnet Collaborate on New Bike Path at Bayless Elementary\nA team of Spire volunteers constructed an all new walking and biking path on the property of Bayless Elementary School this summer!\nThe project was the result of a collaboration between Trailnet, Spire and Bayless Schools, funded by Spire Serves and carried out by volunteers through Spire’s Day for Good program.\nThe trail will connect the surrounding neighborhood with the school and provide awesome opportunities for bike education and recreation for Bayless students.\n“We love opportunities like this,” said George Godat, Vice President and General Manager MoEast at Spire. “We provide opportunities for our employees to do a day of good in the community each year, and we also have dollars that we put into the community. Trailnet was able to apply for some funds from our Spire Serves program. We gave them $10,000 to provide the materials and labor, then our team came out and got to work. It was the perfect partnership for us and something we’re really excited about.”\nThanks to the Spire Team for cranking out a beautiful path that will result in years of recreation and bike education for our young neighbors!\nImagine being able to move around our city without needing a car. What if you could bike, walk and take public transit to all the places you need to go?\nJoin us for a free, family-friendly celebration and show of support for a car-free or car-light lifestyle.\nThis joyful bike parade will demonstrate the demand for multi-modal transportation options while showcasing the infrastructure and amenities we have in place currently. Stay after the ride for a resource fair where you can learn about how to get around St. Louis without a car and how you can stay involved in the movement for Streets for All!\nThe next time you buy something in the City of St. Louis, take note of the sales tax at the bottom of the receipt. A portion of that tax has been the city’s primary means of funding infrastructure improvements since 1993. Thirty years later, the process for allocating that tax funding, called “Ward Capital,” is being reconsidered. Here’s why that number on your receipt matters, how the funding is currently being used and why the funding process needs to change.\nThe City of St. Louis currently has a ½-cent sales tax in place. This tax collects, on average, $8 million per year for capital improvements in the city. That sum is currently the City’s primary means of funding infrastructure improvements in all 28 wards.\nAt the beginning of each fiscal year, the $8 million total is split into 28 equal parts and distributed evenly to each ward. That’s about $300,000 per year, per ward, to be spent on capital improvement projects—filling potholes, replacing streetlights, street trees, improving sidewalks, etc.\nIf an alderperson chooses to spend their Ward Capital, they must first submit a project proposal. Once the project is approved, the alderperson takes the necessary funding from their pot of accrued Ward Capital and gives it right back to a city department. Ninety-eight percent of the Ward Capital from all 28 wards ends up in the hands of the Streets Department.\nThe current system is convoluted. It also further divides our city.\nOur streets do not stop and start at ward boundaries, nor do each of these wards have the same needs. This system allocates funding equally, not equitably, and results in fractured, short-term solutions applied at the whims of 28 politicians.\nA convoluted system\nLet’s revisit the $300,000 per ward. That sounds like a lot of money, but according to St. Louis Board of Aldermen President Megan Green, recent traffic calming projects around Tower Grove Park cost over $1 million. Her ward received a grant for that work, but had Green relied solely on ward capital, she would have had to sit on her yearly allocation for at least four years to save enough money for those few improvements, and no other projects in her ward, such as street lighting or dumpster replacement, would have been funded in that timeframe.\nMeanwhile, Tyus, who chairs the City’s Streets, Traffic, and Refuse Committee, has saved up nearly $2 million in Ward Capital over the years. Tyus has previously claimed obstacles to spending the money on her desired projects.\n“‘They won’t spend it,’ she said at a board meeting in December. ‘They haven’t. I’ve been requesting. I can show you the letter.’”\nCurrently, alderpersons have $8 million in accumulated ward capital money that could be in use to repair our infrastructure.\nDivisive and fractured\nWhether they’re saving money for one big project or spending it on immediate needs, it’s clear that the current system leaves alders with no choice but to apply a patchwork of fixes to a city-wide network.\nIn her Riverfront Times Op-Ed, Mayor Jones hinted at a bigger-picture need, for which Trailnet has been desperately advocating—the need for a comprehensive plan in the City of St. Louis.\nWard-by-ward “piecemeal solutions” prevent the city from effectively planning for a safer, more accessible transportation network. If the Streets Department doesn’t know what projects lie ahead—if city departments are paralyzed by the inaction of individual leaders—they are not afforded the time or resources to plan for long-term fixes, staffing needs, or equipment purchases.\nIf the city continues to react only to the small-scale symptoms (potholes, crumbling curbs, etc.) of a large-scale, decades-old problem, our streets will never be safe for people outside of cars.\nWhatever the new comprehensive system is, it needs to take into account the areas of greatest need.\nTrailnet recently completed a full sidewalk assessment of The Ville and Greater Ville neighborhoods—the first complete study of its kind in the St. Louis area. Trailnet’s Community Planner walked over 30 miles of sidewalk, marking sections that were ADA-non-compliant, inaccessible or nonexistent. Forty-seven percent of the 61 miles of sidewalk assessed in The Ville and Greater Ville were in need of significant repair.\nThis study is emblematic of the largest issue with the current system—different wards have different needs. Trailnet’s annual Crash Reports identify the highest crash corridors across the city. Our analysis of crash data consistently reveals a glaring truth: Black and minority communities suffer from a disproportionate amount of traffic violence. The state of the streets, sidewalks and intersections on the Northside is one of the reasons why that disparity exists.\nAs a result of decades of disinvestment, Northside streets and sidewalks need far more attention and funding. It is unacceptable that all of these areas currently receive proportionate funding to address disproportionate realities.\nThe northside wards are the areas of highest need—the areas where it’s unsafe to walk, bike or catch a bus. These are the areas that must be identified as the highest priorities in the city’s comprehensive plan. These are the areas that must receive the largest investment from the ½-cent sales tax.\nA number of systems might work more effectively than the current one. What matters most is that the current system be replaced by something better, something equitable, something that makes sense.\nTrailnet’s recommendation is that the city do away with the ward-based capital improvement system. Instead, centralize the funding structure under one city department, and ensure that the money is being invested based on the infrastructure needs identified by a future comprehensive street study, as well as demographics such as poverty levels and car ownership. Treat the whole body, not its disparate parts, in pursuit of a safe system for everyone.\nIf you agree, contact the President of the Board’s office and your alderperson to voice your opinion. As the city moves from 28 to 14 wards this year, there will be many changes. A new and improved system for funding infrastructure improvements must be one of those changes, so that when you pay that sales tax, you know your money is being used to make our whole city better.\nTrailnet will continue to advocate for a new system that better serves the people moving around our city. To stay informed on our advocacy work in the City, subscribe to our newsletters here.\nTrailnet Recommends MoDOT Implement Federal Bipartisan Infrastructure Law in a Way That Prioritizes Vulnerable Road Users\nThe Bipartisan Infrastructure Law (BIL) lays out several steps for states, Metropolitan Planning Organizations (MPOs), and cities to take to better support the needs of people who walk, roll, bike, and use public transit.\nIn this joint letter, MRT, its leadership, and leaders from the health and accessibility sectors across the Show-Me State asked for details on how MoDOT plans to support these vulnerable road users through their implementation of the BIL. You can read the full letter below:\nAmong other opportunities, the Plan4Health project lead to a renewed connection between Trailnet and local bicycle advocate Martin Pion. Martin has been working hard to create dialogue around effective measures for traffic calming. He was very generous in allowing Trailnet to use his temporary speed cushion at one of our four traffic calming demonstrations.\nSpeed cushions are similar to speed humps, but they have a smaller surface area and can be offset with wheel cutouts, allowing larger vehicles (like emergency vehicles) to pass through without reducing their speed.\nTrailnet thanks Martin for the donation of his speed cushion and for sharing his resources with us. To learn more about Martin’s work please read this article he posted on traffic calming.\nTraffic calming: a lighter, quicker, cheaper way to policy change\nSt. Louis’ most recent effort toward creating safer streets consisted of brightly painted tires, colorful cones, plants, and signs. The Healthy Eating Active Living (HEAL) Partnership in the City of St. Louis is using pop-up traffic-calming demonstrations to raise awareness on how to create safer streets. The materials from the demonstrations will be used to develop a traffic-calming lending library.\nPlease watch this exciting recap that highlights the positive effect the Plan4Health grant has brought to the community.\nThis new opportunity for the City comes from a Plan4Health grant from the Centers for Disease Control and Prevention (CDC), in partnership with the American Planning Association (APA) and American Public Health Association (APHA). The objective of the grant is to bring together those who work within planning and public health to improve their communities and make them become more loveable.\nThe City of St. Louis is like many other cities—built for cars to have the largest advantage in transportation. In the U.S., 12 percent of fatal traffic crashes involve people walking, In St. Louis, however, that figure is 36 percent. In the first six months of 2015, 15 pedestrians were killed in the City of St. Louis, many in hit-and-run incidents. These sobering statistics earned St. Louis a designation as a Focus City by the National Highway Traffic Safety Administration, joining 21 other U.S. cities in which pedestrian deaths are higher than the national average.\nData has shown that wider roads lead to a faster rate of travel for people driving. The graphic below illustrates how higher rates of speed lead to higher rates of traffic fatalities.\nMany streets in the City of St. Louis were built to accommodate streetcars and high levels of traffic, so some residential streets are as wide as 65 feet. The traffic calming pop-ups have been a great way for the City and residents to start exploring what to do with the extra space.\nTrailnet, a local bicycle and pedestrian advocacy organization and partner within the HEAL Partnership, has been working to address this problem by implementing several pop-up traffic-calming demonstrations throughout the City of St. Louis. The purpose of the events has been to educate community members, elected officials, and city staff on how we can work together to create safer streets. The pop-up traffic-calming demonstrations are less-than-ten-hour events meant to measure the impact street designs have on people driving as well as listen to the community’s suggestions for safer streets.\nThe Plan4Health grant also offers a unique opportunity for the HEAL Partnership to develop a traffic-calming lending library so community members who are interested in demonstrating their own pop-up traffic-calming events have the resources and tools to use for free. The lending library will come with a toolkit that will list all available materials with instructions anyone can use on how to create their own pop-up traffic-calming demonstrations.\nThese lighter, quicker, cheaper tactics have already shown to be a catalyst for change within the City of St. Louis. The demonstrations have aided in creating new traffic-calming policies and the City of St. Louis has begun to use the traffic-calming lending library for community outreach.\nThese demonstrations are helping the City of St. Louis to create equitable places people love by bringing together planning and public health.\nTo learn more about the St. Louis Plan4Health project, click here.\nThe data from our 2015 walk and bike counts is in. Thanks to the 76 volunteers who donated 152 hours of their time to count cyclists and pedestrians throughout the St. Louis Metro region in September. Collecting such extensive data can be a real challenge, and it would not have been possible without them. You’ve helped make Trailnet a resource for advising the city and other organizations on transportation-related decisions. We have summited the data to the National Bicycle and Pedestrian Documentation Project, which compiles data for use by planners, governments, and bicycle and pedestrian professionals. We also submit the data to local planning agencies and nonprofits to inform plans for better biking and walking.", "label": "No"}
{"text": "Physicians Formula Coupons September 2021\nSave now with Physicians Formula coupons, promo codes, FREE shipping discount & deals September 2021. Don't miss out!\nFree Gift on $35+ Sitewide\n30% OFF All Orders with Physicians Formula Discount Code\nRecently Expired Physicians Formula Coupons\nBig From Physicians Formula! Get 20% OFF Sitewide With Orders Over $45! Promo Ends 4/01, Act Fast\nNEW Mineral Wear Diamond Lip Plumper, Available Now! Shop Physiciansformula Today To Get Yours\nRevive Your Complexion Organic Skin Care From Physicians Formula.Com - Cleansers, Moisturizers, Masks And More\nFREE Shipping On All Orders Over $25, Shop Physician's Formula Today\nCheck Out The NEW Butter Believe It Collection From Physician's Formula, Concealers, Skin Mists And More\nMeet Our New Mineral Wear Diamond Collection From Physician's Formula,\nPhysicians Formula Coupon FAQ\nWhere can I find Physicians Formula coupons?\nYou simply find up-to-date Physicians Formula coupon code, discounts, coupons and promotional codes on SwanCoupon.com. Search for top Physicians Formula discount codes with the red label in the list. All active Physicians Formula promo codes are verified by humans everyday and placed at the top of the list. Another offers and promotions can be found at bottom.\nHow do I use my Physicians Formula discount code?\nFirst, find Physicians Formula coupon code on this page and then click the code to copy it to your clipboard. Next, open Physicians Formula’s website at physiciansformula.com and paste your code in the “Discount Code” box during checkout. You will see a confirmation message of your discounted total order amount when your code is applied, or an error when your code didn’t work. For some discount codes having exclusions, we’ll notate in the description.\nMy Physicians Formula promo code didn't work. What can I do?\nIn case, promo codes may not work because of special exceptions such as the limit for selected products, limited using time. Besides, you can meet the demand of adding your email address during applying the code. Be sure to read exclusions and descriptions carefully. You can also try another Physicians Formula coupon code on this page until you find out the best discount.\nHow often does Physicians Formula offer online discount codes?\nPhysicians Formula releases coupons online periodically. The SwanCoupon.com team checks for new Physicians Formula promo codes everyday to make sure all of them are up to date. Be sure to stop by this page so often to look for the latest Physicians Formula discount code and the best saving on your orders.\nWhat's today's best Physicians Formula coupon?\nToday’s biggest Physicians Formula discount code is for 30% OFF. Out of 8 active coupons, this is the best coupon available until now.\nHow many coupons is Physicians Formula offering today?\nCurrently, Physicians Formula is offering 3 discount codes and 5 offers. Today's best Physicians Formula coupon is for 30% OFF.\nToday's Physicians Formula Offers\n|Best Discount:||30% OFF|", "label": "No"}
{"text": "This week’s Living Arrows shot was taken on Thursday afternoon with N getting ready to play badminton. N had had a bump on the head at school first thing that morning, and he was so shaky I’d had to pick him up to keep an eye on him.\nOh course by afternoon, he was fine again (albeit with a huge egg on the back of his head) and wanting to play outside. He got lots of outdoor toys out, played some badminton (I was forced to take a breather from doing some work), and then I was able to leave him to it.\nHe is a really easy little boy who just gets on with stuff. Yes, he likes to have someone playing with him, but he also understands when he needs to get on with finding something to do himself. When he has great outdoor space like we have, then there’s not really any excuse.", "label": "No"}
{"text": "It’s not a matter of if shipping exceptions will occur in a supply chain; they surely will. And when an exception in shipping occurs, how it’s managed can make all the difference in achieving resilience and preventing ripple effects from wreaking havoc throughout the global network.\nWhat does “shipment exception” mean? To a freight forwarder, logistics service provider, beneficial cargo owner (BCO), or shipper, an exception means that something has gone awry while the container and its contents were in transit, causing a change in the schedule that most likely will result in a delay in delivery.\nForwarders and LSPs want to be the first to know of any exceptions. They don’t want to make educated guesses about where their clients’ containers are, nor do they want to spend time jumping from site to site among carriers to track containers manually. Most of all, they never want to be in a position where they hear about an exception from a beneficial cargo owner or shipper.\nBCOs and shippers, on the other hand, only want to know, “Where is my shipment, and when will it arrive?” When an LSP or freight forwarder cannot provide timely updates--especially in the event of a shipping exception—BCOs and shippers are likely to question why they’re paying for a service that is not providing value. This is why more and more companies are making the smart move and using container tracking APIs (application programming interfaces).\nThis article looks at what causes exceptions to occur in container shipping, the challenges of a reactive approach to exception management, and how taking a proactive stance of exception by management using shipping container tracking APIs yields many benefits. When container tracking is solved, all parties can focus more strategically and proactively on resolving and managing exceptions.\nWhat Exceptions Occur in Container Shipping?\nOcean freight-specific shipping exceptions happen for several reasons, including two related to the schedule changing:\n- Containers get rolled: Due to overbooking, mechanical problems, or weather issues.\n- Omitted ports: A “blank sailing” occurs when carriers cancel the entire route or decide to skip certain ports for various reasons, including excessive port congestion, labor strife, weather, vessel maintenance, or simply to keep the rest of the sailing on schedule.\nIn general, carriers don’t provide great communications while in transit and rarely do they update their customers of these events. If and when a carrier knows they’re carrying containers for a prominent shipper/BCO, they might be forthcoming with a specific update—but probably not.\nSome additional reasons why shipping exceptions occur include:\n- Required documentation is missing: This is especially important when dealing with ocean freight, which often includes additional paperwork that local or ground-based shipments do not require.\n- Compliance/Customs issues: Border inspections, missing data or documentation, improper labeling of hazmat materials, lack of permits/licenses, and incorrect payment of duties and taxes can also lead to shipping exceptions.\n- Forces beyond control: Inclement weather--such as typhoons, hurricanes, and tsunamis--a ship stuck in a canal, civil unrest, and too much congestion at ports can lead to exceptions in shipping. Road construction, inland weather, wildfires, and other “acts of God” can affect port operations and drayage services needed to complete delivery as well.\n- Labeling issues: A missing, damaged, or unreadable label on an ocean shipment very well could lead to a delay or even a return to sender.\n- Holiday closures: U.S. federal holidays, certain international holidays, and countless country-specific holidays and observances (Japan Week, for instance) could disrupt shipping schedules and port operating hours on or around those days.\n- Recipient not available to accept shipment: This was common during the earlier stages of the pandemic as mandates forced non-essential businesses to close or operate with restricted hours.\nWithout end-to-end visibility and an ability to communicate in real-time, stakeholders are in the dark and blind to most instances of exceptions in shipping.\nChallenges of Reactive Exception Management\nMany BCOs and shippers in the container industry are old-fashioned and resistant to change and technology. To them, manual data input is just part of the job. Integrating said data into their existing systems requires too much time and resources. Here is a familiar sentiment: “Hey, we’re a small company with no resources to ingest data, and there’s too much code work involved. Besides, ocean carrier data is a black box; we don’t know if it’s right.”\nThey run into so much frustration when dealing with carriers that they just accept “this is the way it is” and resign to accept these broken ways, which leaves them in a reactive mindset when managing shipping exceptions.\nSeveral things prevent them from taking a proactive approach to managing exceptions in shipping, including:\n- No visibility at all.\n- Inability to get real-time, quality, accessible data around container activity.\n- No integration of that data into a system of record, such as a TMS, WMS, ERP, etc.\n- No ability to cleanse/ analyze data, then communicate to shareholders promptly.\nFew would argue that the goal is to have a more advanced digital supply chain, which rests largely on the quality of the available tracking data.\n“If you want smart exception identification, you need good tracking data. If you want to reduce demurrage fees, you need good tracking data. If you want to understand the performance of carriers, facilities, and trade partners, you need good tracking data, says Kyle Henderson, CEO of VIZION. “And this data needs to be accessible, complete, and available. Historically, you wouldn’t get data from a carrier unless you were one of their largest customers. If you got data, the format was very unfriendly, and you would only receive 60% of the data you needed.”\nThe story is much the same for the LSP and freight forwarder, with some notable additions:\n- They have trouble placing bookings with ocean carriers/finding capacity on vessels.\n- They can’t quickly answer the question, “Where’s my shipment, and when will it arrive”?\n- OTIF rate plummets when freight is late, which leads to fines and also raises the risk of leaving store shelves bare.\n- Might have to use more expensive modes of transportation (air, rail) to get products to destinations on time.\n- Increases BCO/shipper costs because they will need to provide buffer stock.\n- Lack of data also creates operational inefficiencies in warehouses.\nIn short, for all stakeholders, there will be panic that will lead to increased customer service activity and additional costs resulting from poor information. Poor communication with carriers only exacerbates the situation when shipping exceptions happen.\nThe modern approach to manage exceptions in shipping and help shippers and BCOs deliver on increasing customer expectations is to take a proactive approach through automation and container tracking APIs.\nBenefits of Proactive Management by Exception\nAs explained by Supply Chain 24/7, prioritizing shipping exceptions—or the “management by exception” approach—“means knowing how to respond when to respond, and the best way to respond, to eliminate the risk of disruption, and handle adverse events. Even changes within capacity can require exception management, rerouting shipments, and redefining the loads accordingly.”\nAny technology platform for management by exception must include:\n- The ability to define how to handle shipping exceptions.\n- Transaction validation helps flag errors and issues.\n- Real-time alerts and notifications that are auto-distributed to subscribed stakeholders.\n- Data quarantine ensures quality and accuracy.\n- Robust reporting and analysis, which provide visibility into partner performance and crucial metrics.\nVIZION’s container tracking API does all that and more. From a BCO/shipper’s perspective, API technology provides:\n- More reliable/accurate ETAs.\n- Visibility across all carriers in one platform—a single pane of glass.\n- Control over their data so they can plan effectively to create operational efficiencies.\n- Leverage to hold ocean carriers, freight carriers, warehouses, and distribution centers accountable.\n- Efficient information sourcing to make better decisions and assist with root-cause analysis.\n- A proactive approach to identifying and mitigating detention & demurrage.\nFrom the perspective of a freight forwarder and LSP, APIs provide the end-to-end visibility needed to respond proactively to shipping exceptions in uncontrollable situations. This, in turn, offers the following benefits:\n- Access to clean, standardized data across all carriers, showing the status of all milestone events.\n- Data can be pulled or pushed into their interfaces through an adaptable data pipeline.\n- Improves the customer experience and boosts retention.\n- Helps BCO/shipper customers control costs.\n- Improves accuracy by reducing manual, error-prone data entry.\nVIZION APIs enable real-time alerts for blockages and shipment exceptions, along with the ability to address them immediately at any point from the time of loading until container delivery at destination. Along the way, APIs generate daily or hourly reports on container status updates.\nGet Proactive: Take Control Of Shipping Exceptions with Container Tracking APIs\nIt’s never been more challenging for BCOs, shippers, freight forwarders, and LSPs to manage shipping exceptions and know where ocean freight is, when it will arrive, and the reasons for any delays. Our VIZION container tracking API automatically pushes the most complete, standardized, and detailed container tracking events to any TMS, WMS, ERP, other software systems, or spreadsheets. The ease of having access to standardized data through a single pane of truth rather than manually tracking down container status information enables all stakeholders to focus on growing their respective businesses. VIZION maintains a 99.9% uptime performance in our data integrations and covers 98% of global ocean carriers. That’s how we fuel machine learning that drives continuous improvement. When it comes to managing exceptions in shipping, APIs are technology you can trust. Check out our Use Cases and ROI potential for BCO/shippers, freight forwarders, and logistics service providers. Then, schedule a demo at your convenience.", "label": "No"}
{"text": "Goethestr. 58, 35390 Giessen\nEnrolment of Foreign Students\nEnrolment or matriculation takes place at the times given in your Notification of Admission. The mentors in the International Student Advisory Office will provide you with support and assistance during the enrolment process.\nYou will need to submit the following documents when you enrol:\n- Notification of Admission\n- If you have already been a student at another German university: your academic transcript ('Studienbuch') with the official note of the time at which you left the last university at which you took courses\n- College/University Entrance Certificate (original)\n- Proof of health insurance coverage\n- Proof that you have passed the DSH (German Language Examination for Foreign Student Applicants), if the Notification of Admission includes this stipulation\n- Proof that you have paid the semester contribution, as stipulated in the Notification of Admission\nIt is advisable to open a local bank account before you enrol. For information on this, see the Info-Table Orientation for Students.\nYou would like to remove your name from the Register of Students or withdraw your matriculation?\nPlease hand in the Request for Removal from the Register of Students/Withdrawal of Matriculation.\nLearn more about Germany by exploring its cities, towns, and landscapes!", "label": "No"}
{"text": "This page shows the publications Timothy Erickson has written about Poisoning.\nThompson TM, Theobald J, Lu J, Erickson TB. The general approach to the poisoned patient. Dis Mon. 2014 Nov; 60(11):509-24.\nErickson TB, Thompson TM, Lu JJ. The approach to the patient with an unknown overdose. Emerg Med Clin North Am. 2007 May; 25(2):249-81; abstract vii.\nWills B, Erickson T. Chemically induced seizures. Clin Lab Med. 2006 Mar; 26(1):185-209, ix.\nBoren S, Erickson TB. Toxicological deaths of major league baseball players. J Toxicol Clin Toxicol. 1998; 36(7):737-42.\nWills BK, Mycyk MB, Mazor S, Zell-Kanter M, Brace L, Erickson T. Factitious lithium toxicity secondary to lithium heparin-containing blood tubes. J Med Toxicol. 2006 Jun; 2(2):61-3.\nWigder HN, Erickson T, Morse T, Saporta V. Emergency department poison advice telephone calls. Ann Emerg Med. 1995 Mar; 25(3):349-52.\nLeikin JB, Heyn-Lamb R, Aks S, Erickson T, Snyder J. The toxic patient as a potential organ donor. Am J Emerg Med. 1994 Mar; 12(2):151-4.\nHays EP, Schumacher C, Ferrario CG, Vazzana T, Erickson T, Hryhorczuk DO, Leikin JB. Toxicology training in US and Canadian medical schools. Am J Emerg Med. 1992 Mar; 10(2):121-3.\nThe connection strength for concepts is the sum of the scores for each matching publication.\nPublication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.", "label": "No"}
{"text": "In the run up to the General Election a lot has been said, and more often argued, about the economy and the HSE, but what about that rare oul topic, in reality a major existential crisis – climate change.\nOver one thousand scientists have concluded with 90% probability that humans are responsible for global warming. The evidence has been described as unequivocal. Our climate is changing. In Ireland climate change will cause more extreme weather events: more storms, more floods, more power outages, higher road tax and spiralling insurance premiums. Sea level rise caused by melting pack ice and warming water is expected to displace 25–50% of the Irish population who live along the coast.\nSo just what are the political parties proposing to combat climate change? How might a Government keep our phones and laptops charged up with less (or no) fossil fuels?\n- Climate change coverage: 3,100 words\n- Proposal strength: weak\n- Key words: opaque, contradictory, climate low priority\nThe Fine Gael manifesto is one of the longest and in it the Climate Change section is one of the most verbose. The Climate Action and Low Carbon Development Act devised by Government sets out how Fine Gael will produce a National Low carbon Transition and Mitigation Plan. The main proposal set out by the Party is essentially that a climate change plan will be planned should Fine Gael be returned to Government. Without reading further Government publications it is ambiguous just what Fine Gael intends on doing to reach greenhouse gas reduction targets Ireland signed up to at the Climate Change convention last year.\nRegarding agriculture, Fine Gael’s plan to research and plan could be taken as a smokescreen to delay meaningful decarbonisation in the sector. Delaying tactics would allow agricultural production to be ramped up in line with the Government’s agriculture plan: Food Harvest 2020. Fine Gael suggests that Ireland is a current world leader in sustainable food production, but this bold claim is unsubstantiated in the manifesto.\nFine Gael promises to shake up the energy market and make it more competitive, which ostensibly is a good move; however its proposal to split the ESB generation and network arms under the auspices of the ESB Group is questionable. As the ESB is a semi-state body it is hard to envisage the Government buying electricity from private energy firms or cooperatives (as outlined under the Green Public Procurement) over their traditional provider.\nFine Gael supports the exploration and extraction of fossil fuels as a means of boosting energy, jobs and tax revenue. They are also keen to “invest” in future exploration and maintain a stake in the industry. The Party’s enthusiasm for fossil fuels extraction blatantly conflicts with the State’s commitment to reduce greenhouse gas emissions by 20% by 2020. This target is considered by many commentators to be unambitious when compared with pledges made by other developed countries.\nCapitalising on areas of the country suitable to biomass (tree) production is a very worthy idea which would see 6,000 ha of new forests established in the first year of the Forestry Programme. This could provide new income streams to rural communities in areas where land is of marginal value for regular farming. Replacing peat in favour of biomass for energy production would radically cut carbon emissions.\nWind farms have caused much anger in rural communities who have had been imposed by large scale corporate projects. Fine Gael promises to update wind farm planning guidelines in the next term to shift more power to communities. As the senior party in the standing Government this could have been done already. The manifesto suggests “examining” shared-ownership opportunities to involve local communities. As for most of this section in the manifesto the language is ambiguous and sounds non-committal.\n- Climate change coverage: no specific section\n- Proposal strength: moderate\n- Key words: ambitious, specific, limited scope\nFianna Fáil have chosen not to discuss their plans to tackle climate change as a specific chapter in their manifesto. That said the party has some positive ideas for reducing carbon emissions. For example, Fianna Fáil proposes diversifying Ireland’s energy mix and reforming the Commission for Energy to make energy cheaper for business and families. The Republican Party intends to create a Department of Climate Change responsible for climate change policy, while also subsuming related departments, including Environment, Flood Defence, Transport, Natural Resource and Heritage.\nOn the face of it creating a department dedicated in part to the issue of climate change is laudable. Conflicts of interest might arise where sites identified for renewable energy generation exist as current environmental or heritage sites. Bringing climate change and energy generation under one roof should facilitate sustainable energy policies.\nDeveloping public transport infrastructure is recognised by Fianna Fáil as a key action for cutting carbon emissions. In their manifesto they plan to increase investment in CIE by €28.54m per annum to improve reliability of services and increase the attractiveness of using public transport. This investment will be reflected in bus and train fares, which would likely increase for certain passengers. Ambitiously, Fianna Fáil plans to shift the predominant mode of transport from car journeys to public transport, walking and cycling. This has previously been identified as a pro-environmental way individuals can reduce their carbon footprint.\nTo promote the use of E-cars Fianna Fáil proposes waiving motor tax costing the Government €1.3m; implementing free car charging points costing €2.3m; and also continuing SEAI grants to boost E-car sales, costing €4.5m.\nThe manifesto, though ambitious, in some areas does not set out a roadmap with measureable objectives for decarbonisation in Ireland. Although agriculture has been identified as the most polluting sector of the Irish economy, Fianna Fáil does not discuss objectives to reduce associated greenhouse gas emissions, a key area which Ireland should focus on in order to meet agreed emissions targets. Fianna Fáil maintains it is in favour of the EU leading the fight against climate change and ensuring that countries are held accountable to their international commitments.\n- Climate change coverage: 1,400 words\n- Proposal strength: weak\n- Key words: climate aware, unambitious, limited scope\nThe Labour party opens the environmental section of its manifesto referring to the money it has invested in climate resilience to date. The party says it has spent €225m on flood risk management already with plans to spend a further €430m over the next five years. Spending on flood defence in addition to the creation of new flood forecasting services at Met Éireann will come as welcome news to many in areas devastated by flooding. Exhibiting a degree of awareness about climate change the Party “aims to tackle the root causes” of climate change along with the effects.\nLabour maintains that the challenges posed by climate change present an opportunity for development in the sustainable energy sector with a focus on diversifying renewable sources (e.g. bioenergy, solar thermal and photovoltaic). The party states it will provide more funding to the renewable energy sector to attract investment, meanwhile creating “thousands of jobs.” The party avows to facilitate grid access to small-scale renewable energy projects, but stops short of offering any grant aid or subsidies. Labour would see Ireland become a “World leader” in renewables by creating an energy research centre consolidating existing research institutes.\nProposals outlined by Labour to strengthen regulations for energy efficiency, heating and lighting in the residential building sector are certainly a step in the right direction. They could have been more ambitious by targeting power hungry office blocks also.\nLabour states that the coal fired electricity generation station, Moneypoint, will not be substituted by a low carbon-energy source until 2025. The party’s honesty must be congratulated, and yet as the energy sector is a major polluter a diversified energy mix would surely be able to replace some of the energy output provided by Moneypoint before 2025.\nA hardline taken against gas fracking, deemed to be incompatible with a low-carbon energy system, will be welcomed by many opponents.\n- Coverage: 500 words\n- Proposal strength: very weak\n- Key words: unambitious, limited in scope, lacking detail\nSinn Féin has a brief manifesto and by consequence a short section on ‘The Environment’ which includes climate change. The party plans to utilise expert knowledge to set out a roadmap to reduce carbon dioxide emissions. Energy efficiency would be improved by retrofitting insulation in housing as a means to tackle fuel poverty. Though oil prices are at an all-time low and fuel bills will have been helped by a mild winter the Party’s move to improve insulation would benefit those living in poorly insulated homes.\nSinn Féin intends to support community-based power generation and would see that export tariffs offered for small-scale electricity generation are fair.\nThe Party intends to regulate planning to prevent future building on floodplains; an obvious proposal which no party could countenance after the flooding of 2015 and 2009. By establishing a single Shannon River Authority Sinn Féin would ensure that all State agencies would act swiftly when responding to flooding in the Shannon catchment. A single authority could dramatically improve flood prevention in the west and would certainly be embraced by communities along the Shannon corridor.\nThe manifesto states that Sinn Féin is opposed to fracking and nuclear power, which it would not permit in Ireland.\n- Coverage: 1,500 words\n- Proposal strength: moderate\n- Key words: ambitious, self-sufficient, detailed\nA party committed to sustainability, The Green Party has ambitious plans to harness renewable energy generation in Ireland. They would establish binding, national greenhouse gas emission targets for 2030 and aim for 100% decarbonisation of power, and an 80% reduction in total emissions, by 2050. In doing so the Party would end Ireland’s current €6 billion per annum fossil fuel importation bill.\nThe Party would develop a new planning process to include climate mitigation and climate adaptation, which would future-proofing Ireland in readiness for major global warming. To assist in carbon sequestration the Green Party would dramatically increase afforestation, as Ireland currently has the second lowest tree cover in Europe.\nThe Greens would oversee the closure of Moneypoint and the three peat-fired power stations over the life time of the next Government. The manifesto states the Party would create a new marine energy station at Moneypoint and re-train power station workers in a retrofitting capacity to improve heat efficiency in homes.\nTo radically cut emissions the Greens propose ramping up renewable energy supply rapidly. It intends to advance solar and offshore wind power generation, while aiming to reach 40% of the country’s energy supply from onshore wind power. The Party’s plans to power the country with renewable energy are very positive and ambitious, but how this might be paid for is not elaborated.\nThe Green Party plans to introduce a community aspect to energy generation: they would develop a mechanism to allow householders to sell electricity back to the grid. With over one million homes heated by oil the Greens propose expanding the SEAI Better Energy Warmer Homes scheme, which would cost an additional €10m annually and be sought from the European Investment Bank. Evidently some plans require favourable outcomes from funding sources outside the country, but an improvement in insulation would clearly be well received: lower bills, lower emissions and of course warmer houses.\nThe Green Party are against oil and gas fracking in Ireland and would cease licensing offshore oil and gas. It is clear the Party is against facilitating fossil fuel discovery and states that in order to avert dangerous levels of global warming four fifths of oil and gas must remain underground.\nPlacing the environment centre stage in their plan for Ireland the Greens propose amending the Irish Constitution in order to acknowledge the intrinsic value of the environment and its right to exist and persist. The Party supports the proposal that ecocide – a crime against nature and humanity – be created in international law subject to the jurisdiction of the International Criminal Court.\nStanding up for the environment is a tenet of the Green Party. All of what the Party proposes is valiant, however a roadmap detailing funds allocated for transitioning Ireland to decarbonisation is absent from the manifesto.\n- Coverage: 1,300 words\n- Proposal strength: weak\n- Key words: renewable energy, public benefit, lacking targets\nRenua Ireland’s climate change chapter implies a good understanding of the challenges ahead for Ireland when economic growth is considered in the context of resource use and ecological protection. The Party focusses heavily on renewable energy production in a bid to reduce carbon emissions.\nReferencing European reports, Renua suggests that strong tides around Ireland could provide 500% of the national electricity requirement. Harnessing this source is part of the Party’s plan but this would clearly take some time as the methods of effective tidal energy generation are still being researched.\nThe Party favours the use of biomass over home heating fuel. Renua would bring Ireland’s forestry cover up from <10% to 20%; this would provide an economic output for forestry while providing additional carbon sinks, habitat for wildlife and recreational opportunities for citizens.\nOn shore wind turbines as a source of renewable energy are out of favour, however. Renua believes that the “economic case for wind turbines based on current technologies is questionable.” The Party states that current corporatist attitude has seen big developers benefit from licenses rather than local communities. Renua would create a national sovereign wealth fund to manage State assets in a self-sufficient fashion, a policy which would certainly prove popular.\nThe Party proposes retro-fitting homes by grant aid to provide solar energy, integrating solar technology to all new homes and remunerating producers feeding into the national grid. Reducing the financial burden of heating meanwhile offering an income stream to homeowners is a progressive proposal. The Party would also consider co-commissioning solar generation in third party countries if this could be done competitively.\nThe party is against fracking until it can be proven that this method of energy extraction does not compromise natural water supplies.\nThe Renua manifesto for climate change does not set out a road map for greenhouse gas emission targets and no information is provided in the way of funding. Developing the use of tidal energy as Renua propose could prove a real boon for Ireland if the source can be exploited.\n- Coverage: 700 words\n- Proposal strength: very weak\n- Key words: vague, community driven\nThe Social Democrats recognise the need for immediate action on climate change. To do this they would specify targets for emission reduction and fossil fuel use. No preliminary targets are included in the manifesto. The Party would devise “attainable” mitigation plans and enhance the powers of the Climate Change Advisory Council. Attainable plans might of course not be bold enough in terms of meeting agreed targets which could expose Ireland to hefty fines. In order to reduce carbon sequestration, the Party would “encourage” adoption of forests and wetlands. It is not clear whether landowners would receive specific funding for land use change.\nThe Social Democrats propose increasing the funding for ocean energy owing to its “great potential.” Certainly the Party’s intention to set up an Offshore Wind Development Energy in order to simplify regulation and attract investment is wise as Ireland is lagging behind other countries in this sector. The Social Democrats would rethink large-scale onshore wind farms suggesting that community concerns around, scale, height, etc. must be considered. They would see that local communities benefited from their local energy resource as occurs in Denmark.\nIn a credible move toward decarbonisation the Social Democrats would phase out state subsidies for carbon-intense forms of electricity generation. As currently planned by Government the Party would convert peat burning electricity plants to biomass, which would be domestically produced insofar as is possible. In a bid to win over farmers the Social Democrats would expand ‘home’ microgeneration schemes, including photovoltaic, wind and combined heat and power. The Party would “enhance the supports” for home energy, retrofit and conduct a retrofitting programme across all public buildings. The cost to the exchequer associated with these plans is not outlined in the manifesto.\nThe People Before Profit Alliance has a very brief ‘environment’ section, which acknowledges the gravity of climate change. The Alliance supports investment in public transport, retrofitting buildings to improve energy efficiency and increasing afforestation. It supports substantial investment in renewable energies and divesting from fossil fuels. No emissions targets or specific costings are provided.\nThe Anti-Austerity Alliance manifesto is brief. With regard to climate change the AAA proposes investing in State-lead renewable energy production and research to deal with the energy crisis. The Alliance also supports democratic public ownership of the State’s natural resources.\nThe political parties vying for our votes have placed varied impetus on the looming climate change catastrophe. It would appear Fine Gael put economic growth above meaningful measures to counter climate change. Fianna Fáil are reasonably specific in their proposals, providing costings and setting out clear plans. Renua have interesting ideas for energy diversification and would deliver community ownership of natural resources. The Green Party have arguably the most radical strategy for dramatically curbing greenhouse gas emissions but stop short of suggesting clearly how their plans would be financed.\nConsider what YOUR public representatives would do to thwart global warming before you cast your vote. It counts.\nThanks a million for the piece Lawrence I really enjoyed it and hope it reaches as many people as possible before the vote tomorrow! Seems a FF Green coaliation would be the best outcome for the environment then if I read correctly? We must remember I think though that we had that coalition before and the only stand out extra plus I remember was the banning of the stag hunt. Of course they must have done more and if any contributor remembers something else please post! We must make sure this time that the manifestos don’t just become empty promises and allot of hot air which is exactly what the climate doesn’t need! On saying that the best hope I think is with the individual and attitude change in the public and private industry sector which actually looks like it is happening regardless of political parties encouraging it or not. Let’s just hope the victorious party(ies) this election remember how strongly the electorate feels about making Ireland a excellent place to live in, not just for people but for all of the Country’s biodiversity as well.", "label": "No"}
{"text": "South Korea’s Korea Aerospace Industries (KAI) plans to increase its manufacturing capacity for the FA-50 Fighting Eagle by building two additional production lines in 2024.\nAccording to reports from local media, the move seeks to meet the apparent high demand for light combat aircraft.\nMultiple new customers are reportedly considering the Fighting Eagles due to their competitive price and fast delivery timelines.\nKAI’s production facility is currently assembling FA-50s for Poland and Thailand, and the sixth KF-21 Boramae prototype.\nEyeing the US\nKAI’s move to double its production capacity is a company strategy to boost sales in Europe, Asia, the Middle East, and even the United States.\nAfter recent success in Warsaw and Malaysia, it is reportedly eyeing the US as its next major customer.\nThe South Korean firm hopes to secure a large contract from the US Air Force and the US Navy for 500 FA-50 Fighting Eagles.\nThe air force had previously selected Boeing and Saab’s T-7A Red Hawk. However, KAI remains optimistic that it will receive the contract since the project has been experiencing continued delays and cost overruns.\nThe US Navy has also issued a request for information for the T-45 Goshawk replacement program, which places great emphasis on the delivery timeline.\nThe FA-50 Fighting Eagle\nInitially developed for the Republic of Korea Air Force, the FA-50 Fighting Eagle has a tandem glass cockpit that can carry two crew members.\nIt is a light combat version of the T-50 Golden Eagle supersonic advanced jet trainer.\nThe FA-50 features an inertial navigation system, an integrated mission computer, and an identification friend or foe system.\nSouth Korea’s Fighting Eagle has AIM-9 Sidewinder short-range air-to-air missiles and AGM-65 Maverick air-to-ground tactical missiles.", "label": "No"}
{"text": "For more than many years, we have been helping our clients grow their businesses digitally. We can help you reach your business goals online by designing and optimizing websites, as well as SEO and paid search marketing. We are not \"just a digital agency.\" We are striving for more! We want more for our clients and the products we make. High quality is what we value to achieve this goal. How can you say that? Details are the devil. A trustful, transparent, and fun collaboration with clients and partners is what we value as much as having fun at the office.\nSEO Company in Pune\nWhy choose us\nEMS uses white-hat SEO to ensure clients get a genuine ranking for their sales keywords.\nEMS offers a 360 deg plan for SEO that covers branding, leads conversion, and other business aspects.\nEMS vision and mission is to provide a true value even for small businesses in Pune through its flexible SEO packages.\nEMS focuses on ROI and adding value to your business through the right execution.\nEMS-SEO agency in pune Target different things sometimes, such as structural SEO, PPC or FB ads, or improve Social Presence through SMO, mobile-friendly website, or a combination of multiple strategies.\nWe are a digital marketing Company\nWe have some great talented staff\nWe have some great ideas for you\nYour business is our top priority\nWe love our valued customers\nEminence Marketing Service\nWho we are\nEMS is a leading SEO company in Pune, India. EMS SEO team uses the most recent SEO tools and techniques to get your website on the first page of search engines results. Search Engine Optimization plays a vital role in online marketing. Professional Search Engine Optimization or SEO starts when your website goes live. Your website could be lost among the thousands of websites available online. SEO is the tool to prevent this.", "label": "No"}
{"text": "Feb 02, 2017—Feb 04, 2017\nThis workshop aims at fathoming the possibility to create an intelligent app-based payment system (electronic currency) for people living in refugee camps. It should be designed to not only stimulate the economy in the camps, but also feed information back to participants to see their economy emerging and visualize possibilities to create new activities.\nOptions how to create a prototype app will be discussed. To start the workshop a refugee camp in Vienna and several other initiatives that kick started an economy will be visited.", "label": "No"}
{"text": "Posted on July 5, 2020 at 9:28 AM\nA growing number of states have enacted Simon's Law over the past four years (e.g. AZ, KS, MO). They take different forms. Some require only that parents be informed that clinicians plan to write a DNR order for a child. Others prohibit writing the order over parental objection.\nBut a new Iowa statute goes much further. H.F. 594, signed by the Governor last week, prohibits clinicians from going to court for permission to withdraw life-sustaining treatment.\n\"A court of law or equity shall not have the authority to require the withdrawal of life-sustaining procedures from a minor child over the objection of the minor child's parent or guardian, unless there is conclusive medical evidence that the minor child has died and any electronic brain, heart, or respiratory monitoring activity exhibited to the contrary is a false artifact.\"\n|Iowa Governor Kim Reynolds|", "label": "No"}
{"text": "Leading Tips For Finding The Very Best Hotel For Your HolidayHave you ever stayed at a hotel in which you really enjoyed your visit? Now, have you stayed in a hotel that just absolutely made you angry and like you had never been treated so poorly as a guest? This article is going to help you with some information concerning what is needed to ensure you pick the right hotels from now on.\nTo find the best deals on hotels consider a travel agent. Many times travel agents can find wonderful hotels at a great price. When booking with a travel agent, ensure that the agent knows both your wants and your needs. This will allow the travel agent to shop for both and offer you choices.\nTo get the best possible rate for a hotel room, book well in advance of your trip. Rates are markedly higher if you just get the room at the desk. In addition to saving you a lot of money, advance booking will also ensure you aren't left without a room.\nTo save money on a minibar or vending machine at a hotel, pack a cooler before you start out on your trip, and throw in some six-packs of soda or beer and a bottle of wine. When you get to the hotel, if you have a small fridge, you are all ready. If there isn't a fridge, use the ice machine and your cooler to keep things chilled.\nTo keep from paying through the nose for dry cleaning services from a hotel, ask what the costs are before you send your clothing out. If you need cleaning done, it's often cheaper to walk down the street to a nearby dry cleaner. People who are in town on business often benefit greatly from these savings.\nWhen staying in a hotel, it is wise not to bring valuables. If you do have valuable jewelry, documents or other items be sure to stay at a hotel that has a safe in the office. By making good use of this amenity, you can keep your personal belongings secure and enjoy peace of mind.\nTo get the lowest price on accommodations, plan your trip in advance. hotel housekeeping cleaning supplies have a discount if you book your room a month or more ahead of time. visit the up coming internet page can save you as much as 40 percent off of the cost of your hotel.\nTo save money on a trip when you are traveling with a large family, choose a hotel that offers a free breakfast. Even if it's just continental fare, you're saving a significant amount of money by cutting out having to pay for that one meal each day on the road.\nBe sure to check for online deals. Most of the time, you can get cheaper deals by taking a few minutes to search for them on the Internet. It is a great way to choose your hotel. You will find deals this way that the hotels won't tell you about over the phone.\nBest hotel hospitality supplies by Hotels For Humanity\n7910 E Camelback Rd, Scottsdale, AZ 85251, USA\nMake sure that your family enjoys their stay by calling ahead to ensure the hotel's swimming pool is working, Showing up at your hotel and finding out the pool isn't in working order can ruin an otherwise great trip.\nBe aware of the check in and check out times for the hotel at which you are staying. If you arrive too early, your room may not be ready, and you may have to wait a few hours to access it. If you fail to check out by the appointed time, you may be charged for an extra day. Knowing day realty thomaston ga with regard to check in and check out times can save you some aggravation.\nAvoid using the phone in the hotel to make any calls. If you do not have a mobile phone, it would be a good idea to purchase a prepaid phone to make calls during your stay. The only exception should be if free local calls are included in the room rate.\nIf you checked out a hotel price a few weeks ago, be sure to check it out again. Prices for hotel rooms fluctuate not only week to week, but also day to day. There could be a new price available just because you waited. This is especially true if there's a lot of extra room inventory.\nThere are many hidden fees that can substantially increase the cost of your hotel stay. For example, many hotels deliver a newspaper outside of your room and charge you for it. To ensure you are not charged for any unwanted items carefully read the contract before signing for your hotel room.\nTo avoid spending $2 or $3 each time you want a soda at a hotel, throw a six- or twelve-pack into the car when you head out on the road. For almost as much money as that one soda, you can have a dozen of them chilling on ice in the room, or in the mini-fridge.\nNever ask for the minibar to be removed from your hotel room. You may think this is a great way to ensure that you don't partake of the minibar; however, most hotels charge for this service. Instead, if you may be tempted to drink alcoholic beverages, purchase your favorite beverage at a package store.\nTo ensure that you don't leave anything behind when you are checking out of a hotel, make a sweep through the room after you've packed your bags. Open every drawer, check down on the floor by each bed, and check every outlet to make sure that you haven't left any chargers plugged in.\nWhen you have are trying to decide between two hotels, go online and see what the reviews say. Look for reviews that ring true and give actual descriptions of what was good or bad about the hotel. The reviews may also include realistic pictures of the hotel that won't be featured on the picture perfect hotel website.\nIf you have had issues in the past finding the right hotel then perhaps you should follow the advice that you have just read. There is no need to wind up in a hotel that does not provide you with the satisfaction you have paid good money for. It's the hospitality industry, and you are supposed to be in good hands.", "label": "No"}
{"text": "Exxplorer is a US metal act that was formed 30 years ago. They have released four albums up till now. Their last album “Vengeance Rides an Angry Horse”, which was released a year ago, was a pleasant surprise for me.You can read my review for their last album here http://behindtheveil.freehostia.com/october_main.html) while you can also read our interview for the album here: http://www.behindtheveil.hostingsiteforfree.com/index.php/interviews/72-exxplorer-interview. The band seems to be in really good shape right now! This is their second album which was released in 1994, nine years after their classic debut album “Symphonies of Steel” (I have it on a digipack leather package). The songs of the album are mainly in the vein of classic heavy metal but there are some songs that could be characterised as hard rock. The majority of the songs are really good and the album flows really pleasantly. The things that make Exxplorer stand out are the really great voice of Lennie Rizzo and the great guitar solos played by Kevin Kennedy and Edward LaVolpe. The songs that I enjoyed more were “Rockin’ Bound”, “Bible Black”, “Rock the Nation” “Just a Dream” and “Beg, Borrow and Steel”. From the hard rock tunes I’d say that “Life’s Seduction” is a really good one. In conclusion this is a nice album (especially for the time when it was released when bands like Pantera were in their heydays) that the fans of traditional heavy metal should at least try to listen to. In general the three albums of Exxplorer that I have listened to (I haven’t listened to their “Coldblackugly” album which was released in 1996) are really worth listening to and I think that the traditional metal fans should try to buy them!!\n8,5/10 Ioannis “Knight of Light” Kaskamanidis", "label": "No"}
{"text": "Maybe I'll actually get good on it, now that would be learning something. So far, I've found out that 1. The book was wrong on an important procedure. 2. the help file system built into FP2k2 was wrong 3. I'm glad I'm inquisitive and willing to take a chance.I found out how to do it myself, which is ok, but what about all the folks who are not so trusting of themselves?\nI really hate that about the computer industry: they expect people to trust them, when in fact, they don't know how to teach the theory themselves.\nenough. I uploaded chuluch(?) 3 for one of my new icons. I've had it for about a zillion years and just sent it up tonight. I must be getting old.\nok. time to snuggle with my samoyed. woof!", "label": "No"}
{"text": "Ruth was a visiting assistant professor here in Albany several years ago, and her current practice reflects things she did here. Our campus teaching center has been a big promoter of Team-Based Learning for many years. She first encoutnered it here and recommends, as further reading on TBL for anyone interested, a pair of articles written by our local experts. (One of whom is Philosophy PhD alum Kimberly Van Orman.)\nSince February 1999, I’ve had a web page about fallacies. Rather than regurgitating all of the usual ones that one can find elaborated in critical thinking textbooks, I collect fallacies which an author names for just one occasion. These one-offs don’t appear on the usual lists. Authors usually do this to condemn some specific target, one who has committed not some generic error in reasoning but the specific if newly-named fallacy of such-and-so.", "label": "No"}
{"text": "Federal Appellate Rule 32.1 is now in effect, allowing attorneys to cite “unreported cases” done in 2007 and beyond. Prior to Jan. 1st., the local rules still control.\nAll federal courts of appeal permit citation to their unpublished opinions in related cases to show res judicata, law of case, and the like. But before 2007, federal appeal courts differed on the extent to which they would allow unreported opinions in cases that were not related. The Fourth, Eighth, and Federal Circuit courts “discouraged” them; and the Second, Seventh, and Ninth disallowed them altogether.\nThe situation here, on the larger scale, was foreseen by Robert Timothy Reagan of the Federal Judicial Center, who compiled an overview report on each jurisdiction’s position on unreported cases prior to 2007. It’s available here.", "label": "No"}
{"text": "Add 6.4 HP to 2.4 Liter Toyota Camry Engines With K&N Cold Air Intake System\nOne of the most popular midsized cars in the United States is the Toyota Camry.\nThe interior is ergonomically designed for comfort and its soft suspension works\nwell on city streets.\nK&N Engineering has released a 69-Series Typhoon Air Intake (69-8609TTK)\nin textured black for the 2002, 2003, 2004, 2005 and 2006 Toyota Camry and Solara models with the 2.4 liter\nengine. K&N dynamometer tests show a 6.4 horsepower gain at 5600 RPM.\nAir Intake for Toyota Camry and Solara\nTo add performance K&N replaces the original restrictive air intake with\na free-flowing mandrel-bent aluminum tube induction system . The K&N Lifetime Replacement Air Filter (RU-4960) is protected by a powder\ncoated steel heat shield. The heat shield connects into the existing factory airbox mounts. It isolates the K&N Air Filter from the engine compartment and allows the K&N Air\nFilter to receive a consistent flow of fresh cool air. The result is guaranteed horsepower and increased acceleration.\nPower Gain Chart for Toyota Camry with K&N Air Intake\nThe 69-8609TTK can easily be\ninstalled in 90\nminutes or less and is backed by the K&N Million Mile Warranty.\nFind K&N products for your vehicle using the K&N application search then use the\ndealer search to find a K&N dealer in your part of the world.", "label": "No"}
{"text": "The “Barbie” movie has shattered the summer box office numbers. The film also set a first-weekend record for a film directed by a woman.\nCollectors across the country dusted off their old plastic Barbie dolls and put them out on display for everyone to enjoy. Stoneridge Creek resident Dorothy “Dottie” Soule is joining this club. She recently loaned 38 of her 145 fashion dolls to be showcased in the independent living community’s monthly display case.\nIn the past, these cases have been home to the Pleasanton, CA, residents’ collections of coins, election pins and teapots. For Dottie, it’s all about the Barbie dolls.\nDottie started collecting the dolls for her four daughters. But as they got older, she donated them along with their clothes and accessories to Goodwill. That was until 1980, when she started buying them again for herself.\n“I was out shopping, and I saw some Barbies, and they were so pretty. At that moment, I just decided to start buying them again,” Soule told The Independent newspaper during an interview.\nThe collection includes the Barbie Elvis gift set, the Hollywood Legend gift set of “The Wizard of Oz,” Marilyn Monroe Barbie dolls, Bob Mackie designer fashion Barbie dolls, and even some Harley-Davidson Barbie dolls.\nOne of her favorites is the Golden State Warriors Barbie, which was purchased about 25 years ago. “I cherish that one,” she said. Dottie is one of many fans of the university at the Bay Area senior living community.\n“Everyone is coming up to me and thanking me for putting these dolls on display,” she said. “I’m just overwhelmed with people showing an interest like that. I guess the dolls are happier showing off than sitting in boxes in a dark garage.”\n“People are just so in awe of the beauty of this amazing collection,” said Stoneridge Creek Marketing Director Barbara Gilbert. “It has been such a joy for so many. Dorothy’s giving nature and generosity are enriching lives.”\nAbout Stoneridge Creek\nStoneridge Creek is located at 3300 Stoneridge Creek Way in Pleasanton, California. As a Life Plan Community (also known as a Continuing Care Retirement Community), it provides independent seniors with maintenance-free single-story homes, townhomes and apartment homes. Residents enjoy amenities and life-enrichment programming that includes a putting green, swimming pool, two dog parks, library, computer lab and business center, movie theater, and multiple dining venues with meal service.\nInterested in learning more about Stoneridge Creek and why the community is so popular with so many older adults? We invite you to get in touch with us today. Come in and enjoy a meal with our residents. Meet our team members who are glad to answer any questions you may have about living in Pleasanton and our community in general.", "label": "No"}
{"text": "$14.90 – $33.90\nSatin poster print of The Kiss 1988 Movie.\nThis is a brand new poster. It has never been hung or displayed.\nAll of our posters are carefully packaged in order to guard against damage. All posters are one sided unless it clearly states it is double sided.\nDirected by Pen Densham. With Joanna Pacula, Meredith Salenger, Mimi Kuzyk, Nicholas Kilbertus. After the death of her mother, a teenage girl is faced with bizarre supernatural occurrences when her mother’s estranged sister arrives and begins to infiltrate her and her father’s lives.", "label": "No"}
{"text": "June 2015 letter\nThe beginning of the month had a lot of rain and was cool with some short nice spells. Now it is sunny, hot and dry. Everything is growing like mad except my garden. We had a big crop of sour cherries but we did not take as much advantage of them as we have in previous years for various silly reasons (like melons being on sale). Now at the end of the month it is very, very hot.\nI got a blood test and it is better than last years (which was better than the year before). I am trying to loss some more weight but it is hard to get it going. Still I am feeling my age and so is Harry. Even the dog is starting a creak. But we are all three in good shape for our ages.\nThe Cheval Blanc (our local pub) has been sold to the people who live across the street. But they are still going to sell fresh bread which is good for us. It will probably have a name change and I will not longer be able to call it the White Horse.\nHarry has done great work on the garage. I am still getting computers into shape. This is a new site, first month of existence and it is a bit skimpy, sorry. I am not sure how it will work for you. If you have problems or suggestions, let me know.\nI hope my Canadian friends have a good 1st July, American friends have a good 4th of July, here in France we will be holidaying on the 14th.", "label": "No"}
{"text": "Single Women For You In Palestine, InterracialDatingCentral\nDon't Give Up. Discover Hot Single Women Today. Try It!\nMeeting women in Palestine has never been easier. InterracialDatingCentral provides you with profiles of countless Palestine women for you to browse through - find your match today. You've tried your hand at the single life, now try your hand at something much more exciting. InterracialDatingCentral is all about helping people from all different walks of life connect with each other, and has been influential in facilitating the beginning of many longstanding interracial relationships.\nDon't feel lonely any longer. InterracialDatingCentral makes it easy for you to search online for women in Palestine, allowing you to look for the love of your life from the comfort of your computer. Sign up with us today and you could be meeting the man or woman of your dreams tomorrow! At InterracialDatingCentral find someone with similar interests as yourself and start your romantic journey with us.\nMy name is Carla. I am an active independent woman. I have 3 daughters. I like doing anything active, as well as watching movies. I'm very easy going, it takes a lot to get me upset. more\nIM 20 Very Independent Got my own place an do my own things I'm looking for a friend and if something comes more then thats that I currently work for the state so I'm doing good an going bck to school... more\nJust when I was about to give up hope, I met the sweetest guy in the world. Though he is halfway across the world, I have fallen for him in ways I never could have imagined. I cannot wait til he is back in the states. We are looking forward to our future together. I love you, Aaron! read more\nIllinois, United States", "label": "No"}
{"text": "ERIC Number: EJ391431\nRecord Type: CIJE\nPublication Date: 1989\nSarah Elizabeth Stedman, \"Singing and Self: The Psychology of Performing.\" A Review.\nRadocy, Rudolf E.\nBulletin of the Council for Research in Music Education, n100 p23-26 Spr 1989\nReviews a doctoral dissertation that used interviews to determine the concepts that musicians have of performance and self. Summarizes Stedman's interview-based observations and commentary. States that the study may be useful in providing insights into what singers believe about themselves and their careers. (LS)\nPublication Type: Journal Articles; Opinion Papers; Reports - Research\nEducation Level: N/A\nAuthoring Institution: N/A", "label": "No"}
{"text": "Applications in Medicine of Piezoelectric Mini Cantilever Beam\nCurator: Danut Dragoi, PhD\nPiezoelectric materials are now finding applications in a wide variety of environmental conditions and medicine. Such materials are capable of converting mechanical energy into electrical energy. Indeed, when subjected to mechanical stress become electrically charged at their surface and vice versa. In their paper titled “Analytical Modeling of a Piezoelectric Bimorph Beam”, the researchers from Mechanical Engineering Department, Faculty of Technology Sciences, University Constantine 1, Algeria and Departement de Mécanique Appliquée, ENSMM, France, see the link in here, focused on a simple analytical model based on Euler–Bernoulli beam theory with the following assumptions:\n- (a) the piezoelectric layer thickness in comparison to the length of the beam is very thin and\n- (b) the electrical field between the upper surface and lower surface of the piezoelectric layer is uniform.\nThey have applied this model to study its static responses and predict the ambient deformations into usable electrical energy from a cantilever piezoelectric beam.\nThe piezoelectricity of well known materials, such as Pb[ZrxTi1-x]O3 (0≤x≤1) is due to the asymmetry of central atom that creates a local electrical dipole whose amplitude is direct proportional to the displacement of Ti/Zr+4 ions from the center of the crystallographic unit cell. These materials do not possess any piezoelectric properties owing to the random orientations of the ferroelectric domains in the ceramics before poling. During poling, which is an electric field applied on the ferroelectric ceramic sample during the fabrication to force the domains to be oriented or preferred oriented in the direction of polling of the electric field. After poling, the electric field is removed and a remnant polarization and remnant strain are maintained in the sample, so a preferred orientation of the domains exist and the sample exhibits piezoelectricity. We can imagine that a single crystal will have 100% orientation in the direction we like to be, but the processing cost may be prohibited in this way.\nThe work presented in the paper concerns the problems of characteristic phenomena of piezoelectricity. The attention is focused on the different deformations effect by voltage generation of the piezoelectric beam. The relation between the voltage imposed and the curvature is analytically derived which is used to explain the effect of voltage generation as a function of the curvature of the beam. Figure 4 from the paper, shows the deflection family of curves as a function of asymmetry of the four electrodes on the mini piezo beam, where a and b on Figure 4 are the position of the gap between electrodes on two parallel faces of the beam relative to the middle section plan that runs parallel to the longest side of the beam.\nThe dimensions of the piezo cantilever beam are 10 mm x 1 mm x 0.200 mm. We notice the higher asymmetry (high values for a and b parameters) the better, as the slope on lines on Figure 4 are coupled with the beam deflection, the parameter of interest. We remark the case when a=b=0, no asymmetry, the deflection is zero as expected. Also we notice that the device has two piezo materials glued together. The need for two piezo materials is due to the fact that we have four asymmetric electrodes that produce four asymmetric polarizations that induce the necessary curvature of the beam and ultimately the deflection. In order to reduce the mechanical influence of the electrodes on deflections, the electrodes were made extremely thin, about 0.5 microns thickness. The electrodes were glued to the piezoelectric cantilever beam using epoxy. Analytical data showed that the proposed model simulations are in good agreement with the FE results. A detailed analysis of piezoelectric cantilever bi-morph is made on a dissertation thesis, see link in here.\nPushing for deflection parameter higher on piezoelectric devices is now related not only with energy harvesting in industry, but also with medical devices like BioMEMS where short life batteries for powering the electronic microcircuits have a major inconvenient of recharging once they are depleted of energy, and also they have to be replaced after a not so high number of charging cycles.The usage of human body movement is a viable approach for using piezoelectric cantilever beam to power implantable medical devices as well as other microbot and BioMEMS devices. The predictive models presented are very promising and show the trend towards a highly efficient device that will replace the actual batteries in many applications.\nAmerican Journal of Mechanical Engineering, 2016, Vol. 4, No. 1, 7-10, Available online at http://pubs.sciepub.com/ajme/4/1/2 © Science and Education Publishing\nANALYTICAL MODELING AND DESIGN OPTIMIZATION OF PIEZOELECTRIC BIMORPH ENERGY HARVESTER by LONG ZHANG", "label": "No"}
{"text": "Responsive Magento Thema over Kunst Galerij №49145\nONE Lidmaatschap $229/jaar $179/jaarOnbeperkte Toegang tot 71.000+ digitale items Download dit Item Gratis met ONE\n1 beoordelingen voor dit product\nMy new template 49145 is a winner. I develop for my own use and are very impressed with the design and functionality. I selected template 49145 based on design and colors for my site http://www.ulrikskjaerbaek.dk I love the great trading center of template monster and this is the third and best template I even bought. I needed support from templatemonster to my css guarantee. This only works because I got the best service and support. For me it is important there is live support 24/7 and I can definitely recommend the purchase of template monster.\nThank you very much for your feedback! Were glad youre satisfied with the purchased template and our customer service. Were looking forward to seeing your site when its finished.\n0 commentaarvoor dit product", "label": "No"}
{"text": "“My intention was to transform an insect and a human to highlight our interdependence,” said Charmaine Heyer, a professional photographer based in North Queensland, winner of Australia’s inaugural Epson Print Award, presented in Melbourne.\n“This ‘Creative’ category image started from a fashion shoot,” Heyer said. “I’m thrilled the judges saw merit in this creation. By participating in awards, you extend and grow as a storyteller, not to mention the wonderful photographers you meet along the way.\nThe inaugural Australian Photographic Prize (APP) event – a conference and exhibition, including live judging, took place over four days in Narre Warren, on the outskirts of Melbourne. Hundreds of enthusiasts and professional photographers came together to showcase their work, intervening with a national photography community awards event in place of the now defunct Australian Institute of Professional Photography APPAs.\nThe Australian Photographic Prize is divided into two main categories: the Nikon Digital Awards for amateurs and the Epson Print Awards which are open to all photographers but include professional categories such as Wedding and Commercial. The Nikon sponsored prizes accept digital image files and the Epson prize only accepts prints.\nCamberwell Camera Club member David Bignell won the Nikon Digital Award with a reflective self-portrait.\n“My photo is part of a series I did during lockdown,” Bignell said. “He uses a visual metaphor to convey the message of someone who is literally washed out. The idea of experimenting with tissue paper was born out of thoughts about processing floating emulsion. Once I started printing on fabric, I considered the possibilities of connecting paper to emotions. I started creating self-portraits with torn fabrics, damp fabrics, wrinkled fabrics, etc. The Fragility of Tissues felt apt to describe the fragility of the mind under different pressures. Ironically, being cooped up opened the door to a new creative space to explore and a Zeitgeist to capture.\nAustralian Photography Prize organizers Robyn Campbell and Karen Alsop reported strong attendance at the event, despite pandemic concerns: We had students from local primary and secondary colleges in attendance, as well as a strong mix of enthusiasts and professionals who all came together to be part of the event.\n“For an inaugural event, we achieved a higher than expected number of registrations. On-site event attendance could have been stronger, however, given the current societal shift away from face-to-face interaction. faced due to pandemic concerns, attendance numbers were promising for future growth.Live attendance was strong across all events, with students from Charters Towers in Far North Queensland, up to foreign participants from America listening.\n“We would like to thank our sponsors, especially Nikon, Epson and Kayell who have joined us as visionary sponsors.”\nA 2023 Australian Photography Award is planned for next year, possibly early August.\nMore photos and details APP 2022 here.", "label": "No"}
{"text": "The Gamma-Rayleigh Distribution and Applications to Survival Data\nStudies on probability distribution functions and their properties are needful as they are very important in modeling random phenomena. However, research has shown that some real life data can be modeled more adequately by distributions obtained as combination of two random variables with known probability distributions. This paper introduces the Gamma-Rayleigh distribution (GRD) as a new member of the Gamma-X family of generalized distributions. The Transformed-Transformer method is used to combine the Gamma and Rayleigh distributions. Various properties of the resulting twoparameter Gamma-Rayleigh distribution, including moments, moment generating function, survival function and hazard function are derived. Results of simulation study reveals that the distribution is unimodal, skewed and normal-type for some values of the shape parameter. The distribution is also found to relate with the Gamma, Rayleigh and Generalized-Gamma distributions. The method of maximum likelihood has been used to estimate the shape and scale parameters of the distribution. To illustrate its adequacy in modelling real life data the distribution is fitted to two survival data sets. The results show that the distribution produced fits that are competitive and compared better, in some cases, to the Gamma, Rayleigh, Weibull and Lognormal distributions.\nKeywords: Gamma-X family, Gamma-Rayleigh distribution, Maximum Likelihood estimators, Survival data.", "label": "No"}
{"text": "Dr. Phil & Kari Oldham\nPutting Cookeville on the Map Through Higher Education\nCookeville’s Most Influential People – Class of 2022\nTake one look at Tennessee Tech University’s thriving campus and you will understand why Dr. Phil Oldham has monumentally affected the city of Cookeville. As President of Tech, Dr. Oldham has spearheaded several projects and education-based initiatives.\nCuriosity for higher education is second nature to Oldham, whose father was a college administrator. “I grew up kind of a campus rat,” Oldham laughed. With a B.S. in Chemistry and a Ph.D. in Analytical Chemistry, Oldham was certainly positively influenced by his upbringing. He spent 21 years at Mississippi State University as a professor of chemistry and another five as a Provost and Senior Vice President of Academic Affairs at the University of Tennessee Chattanooga. “During my time at MSU, I learned how a university can be so influential and important in economic development in a state or region,” said Oldham.\nIn 2012, Oldham landed the position of President at Tech and during his 10 years in the role, he has changed the trajectory of the university. A few highlights include increasing full-time faculty and their salaries by 15%, the lowest student debt in the state of Tennessee, investing more than $400 million dollars in capital improvements, creating Tech Farms, initiating significant expansion of existing academic programs and much more.\nWith so many items already in motion or completed during Oldham’s time as president, he has no plans of slowing down.\n“I feel like we are just getting started,” said Oldham.\n“Over the last 10 years we have worked hard to lay foundation pieces. We plan to grow the research presence on campus and still have ambitions to increase enrollment to over 15,000 students in the not-too-distant future,” he continued.\nTrying to keep up with the ever-changing technical world is a full-time job. Oldham is making it a priority to ensure Tech has its finger on the pulse of the jobs of the future. “We are expanding horizons in terms of the type of programs we offer,” noted Oldham. “We have to continue asking ourselves what technology hasn’t been considered and where the future of tech lies.”\nThe economic benefits that a university brings to a community are vast. As Tech continues to thrive and grow, so will the population, jobs, wages, and business and restaurant integration. These are all top of mind for Oldham who prides himself on community partnerships and development. “The level of partnership in Cookeville is outstanding,” said Oldham.\nThroughout his career, Oldham’s wife Kari has been the student outreach counterpart to his academic efforts.\nWith a background in social etiquette via her own company, Southern Civility, Kari Oldham has always valued small gestures that can make a big impact on someone’s day. Now in her role as First Lady of Tech, Kari’s favorite duty is expanding on Tech’s “Live Wings Up” mantra. So much so, that she launched ‘Wings of Kindness’ at Tech which recognizes students, faculty and staff who go out of their way to do something kind for someone else. Among other outreach items, Kari also initiated a “lighting of the quad” before students leave for the holidays. “We light up the trees and bushes, play holiday music, have photo props and create a fun, Christmas feel that lifts the students spirts,” said Kari.\nDr. Oldham and Kari have four children, two of which graduated from Tennessee Tech. “I think Cookeville has the best hometown feel. There is an inclusive vibe in this town, and we all want the community and university to thrive,” said Kari.\n– by Chelsea Dartez", "label": "No"}
{"text": "Parsing Science is an innovative way for students to learn about scientific research and how it actually gets done. Consider using one or more of the assignments below in your next courses. You can, of course, edit any of these assignments to better fit your context.\nInterview a Researcher\nGet your students engaged in the research and the scientific community by asking them to record a Parsing Science style interview of their own. Have students identify a research article of interest and then contact the author about being interviewed. In preparing for the interview, students will have to read and re-read the article several times in order to develop probing questions. You may want to review (or grade) the questions prior to the interview.\nThere are a variety of tools that students can use to record their interviews. Mosts easily students can use a free conference calling services (such as Free Conference Calling) that allows for recording calls. With a free account students will be given a conference call dial-in phone number that they and the guest will use for the interview. At the beginning of the call students will give the “host password” and then press 5* to start recording the conversation (or log into the website and manage the call through the dashboard). After the interview is complete and the recording has stopped, an MP3 file of the interview will be available for download from the FreeConferenceCalling website. Other free options including using Audacity or QuickTime (on a Mac) to record Skype call, or PC users there are, for example, software applications (such as MP3 Skype Recorder or iFree Skype Recorder) that record Skype audio calls.\nSuggested questions for researchers could include …\n- What previous research influenced your thinking as you developed the idea for this study?\n- How did you get to know your co-authors?\n- What was novel about your approach to answering the research question?\n- Tell me about something that didn’t go as planned during the research?\n- Are the data and analysis scripts available for other researchers to use?\n- Looking back at the research, what would you do differently?\n- What do you believe are the practical applications of what you learned?\n- How have the results of this study influenced your research since?\nThese researcher interviews can be graded, for example, on on the following rubric …\n- The questions provide evidence that the student was prepared for the interview (30%)\n- The interview covered essential elements of the article (e.g., hypotheses, methods, analyses, results) (20%)\n- Additional information, beyond what is in article, was discussed (20%)\n- The interview highlights how the research can be applied by other researchers or practitioners (20%)\n- The interview was conducted in a professional manner (10%)\nDesign a Replication Study\nHave students select an episode from Parsing Science. After listening to the episode and reading the original article in detail, ask the students design a replication or expansion study that would attempt to produce similar results and demonstrate the saliency of the research. The study could be designed to reproduce the same results with a parallel study, or it can expand the research to see if the results hold for a new population or environment. The original article can, of course, provide the nuts-n-bolts of the design, and the Parsing Science episode will illuminate some of the challenges and opportunities of doing the study.\nStudents submit a research design proposal as a final product. Each design paper can be graded, for example, on the following rubric …\n- The design illustrates an deep understanding of the research question and how it was explored by the original researcher (30%)\n- The design demonstrates the students ability to create a research proposal with appropriate elements (e.g., hypotheses, methods, and analysis techniques) (20%)\n- The design adds value to the original research either to replicate or expand the research (20%)\n- The design adds new research (and/or comparable) research perspectives to the original study (20%)\n- The design proposal includes appropriate citation and references (10%)\nLet Us Know\nIf you find other ways to use Parsing Science in your courses, please and we’ll add them here.", "label": "No"}
{"text": "Core team here We have reached the point in RF and Client development that we need to provide HackRF as a reference design option (for people to use).\nThe work required is mainly to interface RigCtld (from Hamlib) with GNURadio. An all mode demodulator on GNURadio may be used (or written from scratch), controlled by SatNOGS Client using rigctld. The output may be stdout for now (or even decoded to replace multimon-ng usage in the future).\nAny advice, help, takers? Specific requirements can be provided to anyone interested on working on this.\nThe HackRF is an interesting piece of hardware for lab tests, but without proper amplifiers and filters it is pretty much deaf. It would be really interesting to implement a transceiver and a LNA + band pass filter + antenna switch + PA to implement an automated base station, but you definitely need the LNA and the band pass to be able to receive satellites with the HackRF\nAnd about the support, just support gr-OsmoSDR and you will be interfacing with a lot of different SDRs\nThe gr-osmosdr suggestion is a good one. I don’t know why any direct integration with GNU Radio would be necessary for RigCtld.\nI think the best reasons for HackRF One support are that it is open source hardware and it is the lowest cost transmitting SDR platform. It can be made to perform quite well for particular applications by supplementing it with external filtering and amplification.\nWith some of the basics of satnogs working, I can think about the rotator/radio/antenna part. I have a HackRF One waiting for a job, so this could be it Any pointers to suitable “external filtering and amplification”?\nI’m new to the HackRF (but familiar with SDR generally) - is it really that much more deaf than an RTL-SDR dongle? I note that  seems to have suitable LNAs for about 20 Euros. Someone on the HackRF list claims it will bring the overall NF on a HackRF down to ~1.1dB at 430MHz  which is a bit below standard RTL-SDR dongles. There’s also a few open designs around the place, Eg. \nI could take a shot at designing one myself, but I’m more experienced at building filters, which you also mention. I’m new to working satellites. Is there a reason why the HackRF would need filters where the RTL-SDR doesn’t? Or have I missed something - perhaps RTL dongles do need filtering also?\nFWIW I’m here because I’ve recently talked some people at our local hackerspace  into helping me build an amateur satellite tracking station\nOk then. I’ve ordered the loxodes PCB and will try to remember the components in my next digikey/mouser/whatever order. I have access to an SDR-Kits VNA (among other things) and could probably set up to compare noise factor with the LNA4ALL but this will probably be a low priority at least for a while.\nIn the meantime I will be proceeding with the LNA4ALL. I’ve been playing with Coilcraft 0805 SMD inductors on another project but the cost of these add up quick and probably conflicts with the low-cost mission of SatNOGS so I’ll work on sticking to lower-cost passives.", "label": "No"}
{"text": "When Spring arrives don't you always start to think about the colors that you would like to wear during that season? Nothing has been on my mind more than the color that I will be wearing on my nails. I have been in search of this limited edition Dior Long- Wearing nail polish in the color Poison which is a dark blue (pictured below). I already have a blue nail polish but it is so dark that it basically looks black which is not what I want. This Dior polish appears to be the perfect shade, I have scoured countless Sephoras but to no avail. This polish is only sold at Sephora so I am beginning to think I just wont be able to get it...sigh. I even went online to the Sephora site and the product is temporarily out of stock. While I may not get my product, which items are on you itching to get this Spring?", "label": "No"}
{"text": "read.cash is a platform where you could earn money (total earned by users so far: $ 828,292.35).\nYou could get tips for writing articles and comments, which are paid in Bitcoin Cash (BCH) cryptocurrency,\nwhich can be spent on the Internet or converted to your local money.\nI don't want to hear about your situation or your excuses look, everybody has their own, nobody has a clear-cut winning path that is free of resistance and failure to the top of the mountain.\nEvery single big name that we could have experienced massive failure to some extent Thomas Edison, a man he tried ten thousand times before he got his light bulb to light up the first time and that invention changed the course of the world.\nHenry Ford, another guy who had multiple failed automotive businesses before finding success, JK Rowling started on Harry Potter as unemployed recently divorced single mother none of these stories experienced success.\nThe minute they decided to try to do something but instead of what most people do and quit they kept at it, assuming you're going to go out there and kill it on your first try, guys, is an arrogant thought it's extremely naive you have to look at failures as unavoidable they're part of the process.\nThat's just the way it is they're going to happen, and they're going to happen to you, they're going to happen to your loved ones they're going to happen to your kids, and they're going to happen a lot all you have to do is figure out why it happened and avoid that pothole the next time you walk by it.\nFailure is not an option it's not a button, it's not a label it does not exist look, if you've been doing 10 things and ain't working do 11. What's going to happen if you quit? Like, you're not 100% sure what will happen if you keep going like, you're not 100% sure if you give it one more crack at it.\nIf you give it one more chance like, you're not a 100% sure what's going to happen it's like a 50/50 chance it could be 70/ 25, 90 /10 I'm not sure, but I know a 100% of the time when you quit, when you fail, when you give up I know what that looks like so whatever you do man don't give up what you can do is bounce back what you can do is being resilient.\nWhat you can do is turn that whole thing around become great each time you start something new you have to understand that you are going to fail not just once not just twice but logically dozens of times throughout your life and the difference between people who make it and people who don't is how much of the things they're willing to put up with once you come to terms with that.\nYou'll be able to start to recognize where you are in the cycle and begin to start moving forward from there you've got to view failure as part of the equation it is part of the success equation trying to create success without failure is the same thing as trying to make a cake without sugar or butter", "label": "No"}
{"text": "Manual create account\nThis video shows a surgical operation of an abscess that has calcified into a stone.\nYou need to login to download this video.\nlogin or signup\nTags: Brain Stone Calcified Abscess\n( Send Message ) on 28-11-2011.\nDnatube suggest users to have interest in drug testing, mesothelioma, insurance, medical lawyers.\nDuration: 1m 55s", "label": "No"}
{"text": "Barbara Sanders Shares Her High Energy and Talent with Florida Oceanographic Society\nBarbara Sanders always had her eye on volunteering at the Coastal Center, but when she moved to Stuart in 1983, the timing wasn’t quite right. This Kenmore, New York native worked full-time in real estate for 25 years, and eventually retired to become a caregiver for her mother and her husband David. When they passed, Barbara was ready to join the Florida Oceanographic Society’s volunteer family.\n“I grew up swimming, boating and water skiing on Lake Erie, so I’ve always had a deep love of the water,” says Barbara. “I moved to Riviera Beach after college to help my grandmother while she recovered from an injury and decided to stay in Florida.”\nPrior to her career in real estate, Barbara was a probation officer in Palm Beach County. There she met her husband David, who was a judge. They were together for 38 years. Barbara joined the weekly volunteer Green Team at the Coastal Center in 2018 and has given nearly 200 hours of service.\n“I’ve always been a gardener, so the Green Team was a great choice,” notes Barbara. “We work hard, and we also have a lot of fun together. I really enjoy my teammates. Lately we’ve been doing a lot of pepper busting, which means removing the berries from the invasive Brazilian Pepper trees on the Nature Trail so they can’t spread. Eradicating them is a constant effort.” Brazilian Pepper trees were imported to Florida in the late 1880s as an ornamental plant. They have hybridized, and the two Florida species and are hardier and faster-growing than the South American species.\nBarbara has hundreds of bromeliads in her garden, which borders the Club Med golf course. She loves sharing the plants with friends and neighbors. During the pandemic, she started kayaking on the local waters. She also completed a large tile mural on her carport floor in tribute to another of her lifelong interests – fishing. “I love to fish, and I love to share my catch with family and friends,” she says. “One of my favorites is king mackerel. I always keep some to smoke and make into a spicy fish dip.”\n“The Coastal Center is so well-known and respected in our community. Anytime I do errands on my way home from volunteering, people see my volunteer shirt and start up a conversation,” says Barbara. “It’s really such a special place.”\nBarbara Sanders Snapshot\nRaised in: Kenmore, NY\nB.A. in: Sociology\nEarly career: Probation officer, nonprofit probation program director in Palm Beach County\nFav read: A Walk in the Woods by Bill Bryson\nTalents: Fishing, gardening, tile mural art\nGood eats: Anywhere overlooking the water", "label": "No"}
{"text": "A Stanford ER surgeon, Dr. Colin Bucks, is being monitored for Ebola \"out of an abundance of caution.\" Dr. Colin Bucks is the medical director of disaster preparedness for Stanford Health Care and is a clinical assistant professor of surgery at Stanford medical school's department of emergency medicine. Dr. Bucks was volunteering in Liberia with International Medical Corps, a LA-based nonprofit that's not affiliated with Stanford in any way.\nStanford Health Care announced last Thursday that Bucks would be isolated for 21 days \"out of an abundance of caution\" following his last known contact with an Ebola-infected patient. 21 days is the incubation period for Ebola. He has been healthy and asymptomatic since coming back. This response is interesting as we have learned that an Ebola-infected individual is only contagious when he/she is also symptomatic. It seems like an over-reaction and even Stanford Health Care admits that it's kind of a severe reaction. However, we do need to be careful just in case he's infected with a mutated strain that makes him contagious even when he's asymptomatic. This decision was made by Stanford Healthcare according to its emerging infectious disease response plan, which are based off CDC's guidelines.\nDr. Bucks is on paid leave and is \"very cooperative.\" County health officials take his temperature twice a day.\nI initially thought this was an overreaction, but it's actually a pretty chill quarantine. It sounds like a lot of resources are going into this. Speaking of lots of resources, all major hospitals are undergoing significant \"Ebola training\" for relevant employees. It's not the most cost effective approach and it'd be great if all that training money was put into Africa instead.", "label": "No"}
{"text": "Amgen has settled its dispute with Pfizer subsidiary Hospira, which it had accused of infringing a patent covering its blockbuster cancer drug treatment Neupogen.\nTeva Pharmaceuticals has abandoned its lawsuit against Amicus Therapeutics, which it had accused of contravening a US federal law designed to help generic makers bring cost-effective biosimilars to market.\nIn a victory for Bristol-Myers Squibb and Pfizer, the US Court of Appeals for the Federal Circuit has affirmed the validity of a pair of patents covering blood clot treatment, Eliquis.\nThe US District Court for the Northern District of California has denied an attempt by Chinese company BGI Genomics to invalidate an Illumina DNA sequencing patent in a summary judgment, leaving the dispute over infringement of another Illumina patent to be decided at trial.\nBelcher’s chief science officer deceived the US Patent and Trademark Office in order to obtain a patent, the US Court of Appeals for the Federal Circuit has ruled in a win for Pfizer’s subsidiary, Hospira.\nThe US District Court for the District of Delaware has ruled that one of Endo International’s pharma units cannot stop a generic of its blood pressure drug Vasostrict from being made.\nA US District Court for the District of Delaware jury found that German genetics company Qiagen willfully infringed two patents owned by ArcherDX and Massachusetts General Hospital.\nMylan Pharmaceutical and Edwards Lifesciences have joined a petition urging the US Supreme Court to order the US Court of Appeals for the Federal Circuit to reconsider inter partes review petitions that have been denied due to the NHK-Fintiv rule.\nSouth Korean officials have urged the US government to help Korean companies gain access to IP related to producing COVID-19 jabs.\nKite Pharma has successfully persuaded the US Court of Appeals for the Federal Circuit to reverse a $1.2 billion win for the Bristol-Meyers Squibb owned Juno Therapeutics over a cancer treatment patent.", "label": "No"}
{"text": "For about a decade from the late 1990s, Andre Agassi was Boris Becker’s nemesis. The latter’s booming serve was capable of blowing anybody off the court but not Agassi. The American’s return, considered the best in that era, worked only sporadically against the greatest of serve masters Pete Sampras, but almost always against Becker. After having lost his first three matches to Becker, Agassi won 10 of the next 11.\nNot many could deconstruct how Agassi read Becker’s serve. It is perhaps best explained in the words of the man himself. “I watched tape after tape and I started to realise, he had a weird thing with his tongue,” Agassi said years later. “I am not kidding. He would go to his rocking motion, his same routine and just as he was about to toss the ball, he would stick his tongue out and it will either be right in the middle of the lip or to the left corner. So if he was serving in the deuce court and he put his tongue in the middle of the lip, he was either serving up the middle or to the body. If he puts it to the side, he was going to serve out wide.”\n“The hardest part wasn’t returning his serve,” Agassi went on. “The hardest part was not letting him know that I knew this. I had to resist the temptation of reading his serve for the majority of the match and choose the moments when I am going to use that information. I told Boris about this after his retirement. ‘Did you know you used to do this and give away your serve?' He fell off the chair and he said, 'I used to go home all the time and just tell my wife 'it’s like he reads my mind' and little did I know that you were just reading my tongue!”\nIt is the sort of tennis intelligence Novak Djokovic, who is currently in the midst of his worst career-slump, would no doubt like to tap into. And in joining forces with Agassi ahead of the French Open, of which he is the defending champion, he has sought to do exactly that.\n“He's someone that inspires me a lot,” said Djokovic. “One of the things I felt like I needed is new inspiration, someone that knows exactly what I'm going through on the court [and] off the court. He has been through all these transitions, he has been in my shoes before playing Grand Slams, being the best in the world, and facing all the challenges that are present in tennis, in professional sport.”\nFor Djokovic this is no ordinary dip. In the aftermath of completing the career-Grand Slam at Roland Garros last year, there was a perceptible lack of motivation. It was even understandable for there was nothing left to be won. The three-year long association with Becker had delivered the desired results and it was time to move on. When the German was appointed, it was more to impart a cutting-edge to Djokovic’s game than to add new dimensions. Game-wise Becker and Djokovic were as chalk and cheese as it could get, but the two did combine for six Major wins.\nWatch the video:\nHowever, in the months since then, even as his biggest rivals Rafael Nadal and Roger Federer have found their second, third and fourth winds, Djokovic’s game, especially his return, has plummeted alarmingly. On her blog ‘On the T’, Dr Stephanie Kovalchik, a data scientist for the Game Intelligence Group and a Senior Sport Scientist, Tennis Australia, quantified Djokovic’s fall.\nOn clay this year, Djokovic has won only 44% of the total average adjusted return points. The term ‘adjusted’ refers to an attempt by Dr. Kovalchik to account for opponent difficulty and make the numbers more comparable across matches. Nadal in contrast has won a miraculous 51%.\nEven on serve, Djokovic has dropped to 67%, his lowest average serve performance since 2010. On clay, a serve may not be as useful as it is on faster courts because the slowness of the surface reduces the ace count. But for a player like Djokovic, who doesn’t hit as many aces, it’s an effective tool to set up the third shot, which is often a put-away if one serves well.\nA microcosm of this changed dynamic played out in Nadal’s 6-2, 6-4 demolition of Djokovic in the semifinal at Madrid Masters where the Spaniard won a whopping 77.8% of first serve points and allowed only two break-points. Djokovic won a paltry 56.4% of his first serve points.\nSo after having alluded to “personal issues” at first, for which as a remedy he brought in the mysterious self-styled spiritual guru Pepe Imaz, who specialises in meditation and ‘extremely long hugs,’ Djokovic now finds his game following his disturbed state of mind.\nOn paper this appears to be the perfect setting for Agassi to come in and leave his mark. No one understands a game based on a peerless return of serve as much as Agassi. Not many players apart from Djokovic in his prime-have seen the ball so well, taken it so early and moved so quickly as Agassi. No one knows better about emerging out of a slump in the late 20s as Agassi. And there is no one who has mastered the art of work-life balance as much as him.\n“We can relate to each other in many different ways from many different sides,” Djokovic said. “That's why I'm very excited for him being here, because it's a great opportunity for me to learn.”\nThe partnership, as of now, isn’t long-term. Though Djokovic admitted to discussing things with Agassi on a daily basis during the Madrid and Rome Masters, it’s highly unlikely that the eight-time Major winner will once again be ready to embrace the rigours of the tour. He might not even stay for the entirety of the French Open. But it’s no reason to stop the relationship from working.\n“I hope to see one or two of Novak's matches and try to bring to him what I can because even a small remark can do a lot,” said Agassi. In this, the 47-year-old is speaking from experience. In 1992, when Agassi famously beat an ageing John McEnroe in the Wimbledon semifinals before going on to win the title, McEnroe had suggested that Agassi shorten his backswing and take the ball early. It’s a technique which characterised Agassi’s play till he retired.\n“Tennis is about problem-solving,” Agassi said while explaining his edge over Becker. “You can’t solve a problem unless you have the ability or empathy to perceive all that's around you. The more you understand what the problem is through other people's lens, the more you can solve for people in life and in business.”\nIt was an approach which worked wonders during his playing days. Now, as the tennis universe waits with bated breath, Djokovic’s only hope will be for it to be equally successful in his case.\n- Everton boss Dyche calls for sanctions to be applied in off-season\n- Mexican Open: De Minaur battles past Tsitsipas for spot in semifinals\n- Joel Embiid wants to play again this season, for the 76ers and US Olympic team\n- Don’t question my commitment to United, says Rashford\n- AC Milan owners committed to building new stadium", "label": "No"}
{"text": "NBC Chicago. Archived from the original on 8 March Starting Sept. Princeton, IL 4d. Oklahoma City, OK okcfox.\nLivingston County, Mich. Sex portal. Daniel Jr. See also. Most hermaphroditic species exhibit some degree of self-fertilization. According to court documents, Carter is accused of putting his sex organ in the mouth of a male relative on multiple occasions between September and October\nПопали самую man with two sex organ in of Abilene Это\nArchived from the original on 1 July Jeffery G. Oklahoma City, OK okcfox.\nJose Alonso Gonzalez, 37, of Edinburg, was indicted on a charge of continuous sexual assault of a child in connection with incidents that allegedly occurred between January and April Alabama KTBS 11d. Teacher arrested on indecent liberties charges. Severo Valadez Jr. NBC Chicago.\nMan with two sex organ in of Abilene\nfilms like sex and the city in Mandurah\n· ABILENE, Texas (KTAB/KRBC) — The Abilene Police Department (APD) has arrested two men on child sex charges. Police say detectives with the Special Victim Unit arrested year-old Eugene Dwight Thomas, who was charged with sexual assault of a child, a second-degree felony. APD says year-old Javonte R. James was also Author: Joey Hollingsworth. · Two men from Anson and Abilene were arrested for using social media to solicit sexual activity with a 14 year old, Anson Police Department said.\nthe process for the production of sex cells gametes is in Orlando\nAccording to the indictment, Severo Valadez Jr., 30, of Abilene, forced a child under the age of 17 to touch and rub his sexual organ in. In December , Bryce Anthonie McGough allegedly penetrated the sexual organ of a female under the age of McGough was 17 at the time.\nsingle sex schools classrooms in Québec\nAn Abilene man suspected of sexually abusing two children was Both girls reported that Reed had touched their sex organs while they were. Abilene Reporter-News. A Taylor County grand jury on Thursday indicted two men suspected of According to court documents, Carter is accused of putting his sex organ in the mouth of a male relative on multiple occasions.\njessie james sex kitten makeup tutorial in Mississippi\n· Javonte R. James, 27, is charged with second-degree felony sexual assault of a child. Bond for each suspect was set at $52, These two arrests stem from the same investigation. · Abilene man arrested for child sex crime APD says year-old Javonte R. James was also arrested and charged with second-degree felony sexual assault of a child. The two Author: Joey Hollingsworth.", "label": "No"}
{"text": "Introduction to Unique Slots\nI explain how the state of Washington’s system of unique Class III slot machines work at tribal casinos and how to win on them.\nKeep Reading … or Watch Instead!\nTwo Classes of Gaming Machines\nEach gaming jurisdiction is different. Every U.S. state has a different but similar gaming system because Nevada has taken a leadership role in helping other gaming jurisdictions offer gaming for 80-plus years.\nBut Washington handled their startup issues on their own.\nThere are two types of slot machines in the state of Washington, Class II bingo-style competition machines found only at tribal casinos as well as Class III slot machines.\nIn general, commercial casinos have Class III machines while tribal casinos without a gaming compact like Texas have only Class II machines only while federally recognized tribal casinos with a tribal state compact can have both Class II and Class III machines.\nIn Washington, their tribal casinos have a gaming compact. So, they can have Class II bingo machines as well as Class III slot machines. How many of each does a particular casino have?\nThat’s a reasonable question without an easy answer. Casinos don’t tell us that online, including any state with tribal casinos with gaming compacts. Some have all Class II, others have all Class III, and yet others have some amount of both. To find out in a Washington casino, we must walk the gaming floor and observe.\nTwo Types of State Lotteries\nWashington’s slot machines are video lottery terminal run by a state-run lottery. This general approach isn’t unique, as many other U.S. states have VLT slot machines run by their state lottery.\nWhat makes Washington slots unique is that their Class III slot machines are based on the state’s scratch ticket lottery. Other states with VLT slot machines are based on a draw ticket lottery.\nA draw ticket lottery ticket is created at the time of purchase. The player then waits for the drawing where the winning numbers are randomly generated. Sometimes this random number generator is a bunch of numbered balls from which several are randomly chosen.\nA scratch lottery ticket is pre-printed. Once the player buys a ticket, they typically take a coin and immediately “scratch off” a removeable surface of the physical ticket to determine if they are a winner. Any randomness is due to which ticket you are given from a pre-made roll from which your ticket was next in the sequence.\nWashington’s Tribal Lottery System\nIn Washington, Class III slot machines are connected to the Tribal Lottery System (TLS), receives an electronic batch of virtual scratch tickets, then proceeds to reveal the pre-made results one by one as a slot machine is being played.\nThis explanation sounds complicated, but the actual experience of playing is exactly like playing any slot machine. What’s different is how the slot machine works in the background. There is no random number generator. The slot machine results are from a virtual batch of pre-made tickets.\nHow to win on these unique slots is based on details of how electronic scratch tickets are batch fabricated and their subsequent distribution to slot machines in Washington’s tribal casinos. Let’s start by asking these questions:\n- Over how many batches does the 75% minimum theoretical payout requirement apply?\n- How many bets make up a batch?\n- How many slot machines are included in a single batch?\nAnswers from Compact Appendix X2\nKnowing the answer to the first question would tell us if “winning casinos” exist, if it was a huge number, although not which casinos. Knowing the answer to the last two questions help us win at a Washington casino.\nWhat we know from Appendix X2 of Washington’s tribal-state compacts is there are batches from which are made sub-batches. Section 3.2.1 states that batches have the 75% minimum theoretical payout requirement. Section 3.2.4 states that sub-batches have between 5,000 and 10,000 tickets, except for the last batch which can be less than 5,000 tickets.\nWe didn’t get direct answers to our questions. But knowing there are batches and sub-batches is helpful. As is knowing that the 75% minimum limit apples to batches only. And knowing sub-batches have 5,000 to 10,000 tickets is very helpful indeed.\nWith this information, let’s construct a winning strategy for Washington’s unique slots.\nBecause batches have the 75% limit, rather than sub-batches, this means a sub-batch can have:\n- Mostly winning tickets resulting in a greater than 100% payout\n- Mostly losing tickets resulting in a less than 75% payout\n- Both winning and losing tickets with a 75% or so payout\nConclusion? Play sub-batches with mostly winning tickets. But how?\nHow to Win on Washington’s Slot Machines\nPart of finding winning sub-batches is to know more about their distribution. How many slot machines work from the same sub-batch? We can estimate how many by making reasonable assumptions.\nWith 5,000 tickets in a sub-batch, and players making one bet every two seconds, that’s almost nearly three hours of constant play. With 10,000 tickets in a sub-batch and similar gameplay, that’s nearly six hours of constant play.\nIt’s also a reasonable assumption that more than one slot machine works from the same sub-batch, otherwise why bother with the expense of a central server to hold sub-batches?\nAs an upper limit, let’s consider how many slot machines would be too many to work from the same sub-batch. This reasoning comes down to convenience. Whose? Everyone’s!\nIf sub-batches are constantly being replaced because of a large network of slot machines, that’s just begging for maintenance trouble. For instance, a network of one-hundred slot machines means switching out a new 5,000-ticket sub-batch every 100 seconds or less than 2 minutes.\nMaking an educated guess, let’s choose every twenty minutes to switch out a sub-batch. That’s between ten and twenty slot machines in a network when using 5,000 to 10,000 tickets per sub-batch.\nLike two chess players getting to the end of their latest game, do you see how this winning strategy plays out?\nTo win at Washington’s unique slot machines, be the only player on a nearby group of ten or twenty slot machines. You need to only play one of them to collect all winnings in a sub-batch. If you aren’t winning after a little while, move to another group of ten or twenty slot machines and check if its sub-batch is a winner.\nOptimizing this Winning Strategy\nIf someone else is playing “your” group of ten to twenty slot machines, you’ll share any wins. That’s not good if it’s a stranger, but excellent if it’s your spouse.\nOtherwise, there are three things you need to figure out for yourself.\n- When does your casino have so few people in it that you can be the only player in a section of ten to twenty slot machines?\n- How many bets do you make to evaluate if you are on playing through a winning sub-batch?\n- When does the slot machine you are playing finish with a sub-batch and start another?\nYou’ll likely also want to ask yourself if, when you find a winning sub-batch, whether it’s good enough or should you keep searching for an event better sub-batch. And of course, you’ll need to be able to tell the difference between these unique Class III slots and bingo machines.\nYou now know how to go to a convenient store and win at scratch tickets. Buy up to eight tickets in a row from the same spool of a favorite game.\nIf you’re working from a winning spool, you’ll end up with better results than one ticket at a time from different games. That’s how scratch ticket players have told me they win.\nSummary of Unique Slots\nI explain how to win on the state of Washington’s system of unique Class III slot machines work at tribal casinos.\nRelated Articles from Professor Slots\nOther Articles from Professor Slots\n- Previous: Friday Casino Observations to Win at Slots\n- Next: Forthcoming!", "label": "No"}
{"text": "To face the nowdays problem related to ecology and efficiency, APINA’s engineering department has developed its own and exclusive TESTIAC technology. This technology consists in storing cooling energy during 24 hours per day, which will be used to cool the turbines inlet air during the required hours.\nThe core of TESTIAC technology is APINA’s absorption module, which will use the turbine exhaust gases heat to generate the required cooling with only minimum parasitic power consumption for auxiliaries. This low power consumption makes the use of the absorption module suitable even during the power demand peak hours.\nThis way we achieve a better performance of the existing turbines, which may get to increase their power output up to 33% depending on turbine type and ambient temperature.\nDesigning a system with the most appropriate TESTIAC technology requires a detailed analysis of the power plant as well as an evaluation of the different options available. The parameters to be studied include the duration of the power demand peak hours, the turbines performance curves, the capacity of cooling generation and cooling energy storing as well as a study of historic data referring to the ambient conditions at the site location.", "label": "No"}
{"text": "Go to the main menu\nSkip to content\nGo to bottom\nREFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS\n> Journal Vol & Issue\nJournal of the Korean Geotechnical Society\nJournal Basic Information\nJournal DOI :\nKorean Geotechical Society\nEditor in Chief :\nVolume & Issues\nVolume 23, Issue 12 - Dec 2007\nVolume 23, Issue 11 - Nov 2007\nVolume 23, Issue 10 - Oct 2007\nVolume 23, Issue 9 - Sep 2007\nVolume 23, Issue 8 - Aug 2007\nVolume 23, Issue 7 - Jul 2007\nVolume 23, Issue 6 - Jun 2007\nVolume 23, Issue 5 - May 2007\nVolume 23, Issue 4 - Apr 2007\nVolume 23, Issue 3 - Mar 2007\nVolume 23, Issue 2 - Feb 2007\nVolume 23, Issue 1 - Jan 2007\nSelecting the target year\nPerformance of IPS Earth Retention System in Soft Clay\nKim, Nak-Kyung ; Park, Jong-Sik ; Oh, Hee-Jin ; Han, Man-Yop ; Kim, Moon-Young ; Kim, Sung-Bo ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 5~13\nThe performance of innovative prestressed support (IPS) earth retention system applied in soft clay was investigated and presented. The IPS wale system provides a high flexural stiffness to resist the bending by lateral earth pressure, and transfers lateral earth pressure to strut supports. The IPS wale system provides a larger spacing of support than conventional braced and anchored systems. The IPS earth retention system was selected for temporary earth support in a building construction in North Busan area. The excavation was made 28.8 m wide, 52.0 m long, and 16.1 m deep through loose fill to soft clay. The IPS system consists of 650 mm thick slurry walls, and five levels of IPS wales and struts. Field monitoring data were collected including wall deflections at six locations, ground water levels at four locations, IPS wale deflections at thirty locations, and axial loads on struts at twenty locations, during construction. The IPS earth retention system applied in soft clay performed successfully within a designed criterion. Field measurements were compared with design assumptions of the IPS earth retention system. The applicability and stability of the IPS earth retention system in soft clay were investigated and evaluated.\nEffect of Stress-Dependent Modulus and Poisson's Ratio on Rutting Prediction in Unbound Pavement Foundations\nPark, Seong-Wan ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 15~24\nThis paper will present a simple approach (or predicting layer deformation of unbound pavement materials with stress-dependent material properties. The approach is based on an uncoupled formulation in which the resilient and deformation response of unbound materials are considered separately. As a result, an uncoupled approach incorporating a resilient stiffness and Poisson's ratio model is able to simulate field measured deformation in pavement foundations. In addition, a sensitivity analysis is conducted to identify the significant factors in the stress-dependent modulus and Poison's ratio model. The predicted trends of deformation from this analysis are presented and discussed.\nVariation of Earth Pressure Acting on the Cut-and-Cover Tunnel Lining due to Geotextile Mat Reinforcement\nBautista, F.E. ; Park, Lee-Keun ; Im, Jong-Chul ; Joo, In-Gon ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 25~40\nExcessive earth pressure is one of the major mechanical factors in the deformation and damage of Cut-and-Cover Tunnel lining in shallow tunnels and portals of mountain tunnels (Kim, 2000). Excessive earth pressure may be attributed to insufficient compaction and consolidation of backfill material due to self-weight, precipitation and vibration caused by traffic (Komiya et al., 2000; Taylor et al., 1984; Yoo, 1997). Even though there were a lot of tests performed to determine the earth pressure acting on the tunnel lining, unfortunately there were almost no case histories of studies performed to determine remedial measures that reduce differential settlement and excessive earth pressure. In this study the installation of geotextile mat was selected to reduce the differential settlement and excessive earth pressure acting on the cut-and-cover tunnel lining. In order to determine settlement and earth pressure reduction effect (reinforcement effect) of geotextile mat reinforcement, laboratory tunnel model tests were performed. This study was limited to the modeling of rigid circular cut-and-cover tunnel constructed at a depth of\nin loose sandy ground and subjected to a vibration frequency of 100 Hz. Model tests with varying soil cover, mat reinforcement scheme and slope roughness were performed to determine the most effective mat reinforcement scheme. Slope roughness was adjusted by attaching sandpaper #100, #400 and acetate on the cut slope surface. Mat reinforcement effect of each mat reinforcement scheme were presented by the comparison of earth pressure obtained from the unreinforced and mat reinforced model tests. Soil settlement reduction was analyzed and presented using the Picture Analysis Method (Park, 2003).\nCharacteristics of Shear Behavior of Remolded Nak-dong River Sandy Silt\nKim Young-Su ; Tint Khin Swe ; Kim Dae-Man ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 41~50\nThe results from normally consolidated isotropic drained and undrained triaxial compression tests (NCIU and NCID) on sand with high silt content were presented in this paper. The experiments were performed on specimens of Nak-dong River sand with 63% silt content under effective confined pressures, 100 kPa to 400 kPa. From test results, Sandy silt became initially compressive but eventually appeared to provide dilatancy response throughout the entire stress-strain curve The behavior of sandy silt was more difficult to characterize than that of clay and sand due to lower plastic characteristic. Especially, the samples exhibited dilatancy development during shear after failure. The shear behavior and shear strength parameters of sandy silt can be determined as stress-strain behaviors are described by the Mohr-Coulomb failure criterion. The shear behaviors were observed increasing dilatancy volume change tendency with strain-softening tendency after failure. In this paper, the behavior of dilatancy depends on not only sand content but also fine content with low-cohesion during shear in the samples of sandy silt.\nReliability Analysis of Slope Stability with Sampling Related Uncertainty\nKim, Jin-Man ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 51~59\nA reliability-based approach that can systematically model various sources of uncertainty is presented in the context of slope stability. Expressions for characterization of soil properties are developed in order to incorporate sampling errors, spatial variability and its effect of spatial averaging. Reliability analyses of slope stability with different statistical representations of soil properties show that the incorporation of sampling error, spatial correlation, and conditional simulation leads to significantly lower probability of failure than that obtained by using simple random variable approach. The results strongly suggest that the spatial variability and sampling error have to be properly incorporated in slope stability analysis.\nComparative Study between Design Methods and Pile Load Tests for Bearing Capacity of Driven PHC Piles in the Nakdong River Delta\nDung, N.T. ; Chung, S.G. ; Kim, S.R. ; Chung, J.G. ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 61~75\nDeep foundations have been popularly installed in hard stratum such as gravels or rocks in Korea. However, it is necessary to consider sand or sandy gravel layers that locate at the mid-depths as the bearing stratum of piles in the thick Nakdong River deltaic deposits, as done in the Chaophraya (Bangkok) and Mississippi River deltas. This study was focused on the finding of suitable methods for estimating bearing capacity when driving prestressed high-strength concrete (PHC) piles to a required depth in the deltaic area. Ground investigation was performed at five locations of two sites in the deltaic area. Bearing capacity of the driven piles has been computed using a number of proposed methods such as CPT-based and other analytical methods, based on the ground investigation and comparison one another other. Five PDA (pile driving analyzer) tests were systematically carried out at the whole depths of embedded piles, which is a well-blown useful technique for the purposes. As the results, the bearing capacities calculated by various methods were compared with the PDA and static load testing results. It was found that the shaft resistance is significantly governed by set-up effects and then the long-term value agrees well with that of the\nmethod. Also, the design methods for toe resistance were determined based on the SLT result, rather than PDA results that led to underestimation. Moreover, using the CPT results, appropriate methods were proposed for calculating the bearing capacity of the piles in the area.\nElastic-plastic Micromechanics Modeling of Cross-anisotropic Granular Soils: I. Formulation\nJung, Young-Hoon ; Chung, Choong-Ki ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 77~88\nA micromechanics-based model to simulate the elastic and elastic-plastic behavior of granular soils is developed. The model accounts for the fabric anisotropy represented by the statistical parameter of the spatial distribution of contact normals, the evolution of fabric anisotropy as a function of stress ratio, the continuous change of the co-ordination number relating to the void ratio, and the elastic and elastic-plastic microscopic contact stiffness. Using the experimental data for metallic materials, the elastic-plastic contact stiffness is derived as a power function of the normal contact force as well as the contact force initiating the yielding of contact bodies. To quantitatively assess microscopic model parameters, approximate solutions of cross-anisotropic elastic moduli are derived in terms of the micromechanical parameters.\nElastic-plastic Micromechanics Modeling of Cross-anisotropic Granular Soils: II. Micromechanics Analysis\nJung, Young-Hoon ; Chung, Choong-Ki ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 89~100\nIn the companion paper, we provided the novel elastic-plastic constitutive model based on the micromechanics theory. Herein, the elastic and elastic-plastic deformation of granular soils is meticulously analyzed. To guarantee high accuracy of the microscopic parameter, the systematic procedure to evaluate the parameters is provided. The analysis of the elastic response during the isotropic and triaxial compression shows that the stress-level dependency of cross-anisotropic elastic moduli is induced by the power relationship of the contact force in the normal contact stiffness, while the evolution of fabric anisotropy is more pronounced during triaxial compression. The micromechanical analysis indicates that the plastic strains are likely to occur at very small strains. The plastic deformation of tangential contacts has an important role in the reduction of soil stiffness during axial loading.\nEffect of Fines on the Stability of Unsaturated Soil Slopes\nLee, Kyu-Hyun ; Jeong, Sang-Seom ; Kim, Tae-Hyung ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 101~109\nIn South Korea, many weathered soil slopes are composed of soil mixtures with certain amount of clay fractions in natural soil deposits. Accordingly, it is very important to analyze that effect of the fines on the stability of unsaturated soil slopes. In this study, five different soil types classified by mixture portion of fines were used and experiment on the soil-water characteristic curve tests (SWCC) using GCTS (Geotechnical Consulting and Testing Systems) pressure plate were performed in order to analyze the stability of unsaturated soil slopes. Based on the infiltration analysis which contains SWCC test result by the SEEP/W, it is shown that the increasing rate of the wetting band depth was decreased as the fines content and the relative density were increased. According to the stability analysis result of the unsaturated soil slopes through the SLOPE/W, it is found that the transition from the wetting band depth to the variation of strength parameters which affect the stability of unsaturated soil slopes appears to occur around\nof clay contents in the mixtures.\nReliability Analysis of Seismically Induced Slope Deformations\nKim, Jin-Man ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 111~121\nThe paper presents a reliability-based method that can capture the impact of uncertainty of seismic loadings. The proposed method incorporates probabilistic concepts into the classical limit equilibrium and the Newmark-type deformation techniques. The risk of damage is then computed by Monte Carlo simulation. Random process and RMS hazard method are introduced to produce seismic motions and also to use them in the seismic slope analyses. The geotechnical variability and sampling errors are also considered. The results of reliability analyses indicate that in a highly seismically active region, characterization of earthquake hazard is the more critical factor, and characterization of soil properties has a relatively small effect on the computed risk of slope failure and excessive slope deformations. The results can be applicable to both circular and non-circular slip surface failure modes.\nRelationship between the State Parameter and Cone Resistance of Busan Sand\nKim, Seung-Han ; Lee, Moon-Joo ; Choi, Sung-Kun ; Hong, Sung-Jin ; Lee, Woo-Jin ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 123~131\nA series of CIDC triaxial tests and cone penetration tests in calibration chamber were performed to investigate the relationship between state parameter and normalized cone resistance far dredged Busan sand. From the results of the triaxial tests, the critical state line of Busan sand was established, and the critical state parameters found to be\n. By analyzing the state parameters and corresponding cone resistances for calibration chamber specimens, the relationship between normalized cone resistance and state parameter for Busan sand was defined as\n. This relationship was also shown to be independent of the stress history. From the comparison of the slope of the normalized cone resistance, m, and the normalized cone resistance at\n, with those of various sandy soils from over the world, the relationship of m and\nof Busan sand was concluded to show a good agreement with the result published previously, while Busan sand had the largest\namong the soils with similar\nCase Studies of Penetration Characteristics of DCM Wall Using Spiral Mixing Blades in Soil Layers\nJung, Doo-Hoi ; Jeong, Gyung-Hwan ; Yang, Tae-Seon ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 133~140\nDCM (Deep Cement Mixing Method) has been applied to build structures such as self-supported earth retaining walls. DCM columns should be penetrability into the stiff layer to assure the self-supporting ability. On the penetration increase of blade attached to the DCM mixing tools, a spiral mixing blade has been revised. Penetration characteristics of spiral blades in the stiff soil layer were evaluated through Gimhae and Incheon areas. The spiral mixing blades could penetrate into the stiff soil layers which have the N-value of greater than 30 although the penetration rate is somewhat slow. Penetration characteristics and economical efficiency should be discussed to determine the critical depth of the spiral mixing blade because the penetration efficiency can decrease in the stiff layer in this paper.\nEvaluation of the Dynamic P-Y Curves of Soil-Pile System in Liquefiable Ground\nHan, Jin-Tae ; Kim, Sung-Ryul ; Kim, Myoung-Mo ;\nJournal of the Korean Geotechnical Society, volume 23, issue 3, 2007, Pages 141~147\nVarious approaches have been developed for the dynamic response analysis of piles. In one of the approaches, the soil-pile interaction is approximated by using parallel nonlinear springs, namely the p-y curves. Currently available p-y curve recommendations are based on static and cyclic lateral load tests. Other researchers have attempted to extend the p-y curves by incorporating the effects of liquefaction on soil-pile interaction and derived scaling factors of p-y curves to account fur the liquefaction. However, opinions on the scaling factors vary. In this study, the sealing factors, which reflect the variation of the elastic moduli of surrounding soils, were established combining the relationship between excess pore pressures and the natural frequencies of a soil-pile system obtained from Ig shaking table tests and the relationship between the elastic moduli of surrounding soils and the natural frequencies of a soil-pile system obtained from numerical analyses. As a result, the scaling factors were presented in an exponential function.", "label": "No"}
{"text": "After years of being out of the spotlight, my #1 childhood celeb crush, Mr. Jonathan Taylor-Thomas, surfaced a few months ago for some interviews/photo shoot with his former Home Improvement co-stars. I remembered JTT (you know- his nickname used by those of us who were close to him. ahem.) looking exactly like the 1st picture below, ie: super hot to an awkward 12 year old.\n|How youuu doinnnn????- JTT in his prime|\nI was 110% he was still going to be the stone cold fox that he was when I was 12.\nI thought men were supposed to get hotter as they got older, no? Look at Brad Pitt. Leo. Clooney. Hell, even Sean Connery is still kinda sexy in a geriatric James Bond kind of way. Ohhh no- Carol's crush had to peak when he was 16. Big Shock. The Universe just loooooves to play games w/ me.\nAnywho, seeing good ole JTT got me thinking about celebrity crushes. Everyone has one.\nFor example, my dad loves him some Ashley Judd.\nHe used to joke with my mom & say that Ash was the only woman he'd ever leave her for. **Side note- I honestly can't blame him. She IS a UK fan, after all. Gotta love a woman that bleeds Blue.**\nKev absolutely loves him some Kate Hudson & Reese Witherspoon. One major perk about this for me is that he will watch ANY chick flick with either of them in it, regardless of how terrible it actually is. It's kind of a win/win for the both of us. Plus- both women are beyond adorable, so I can't say I blame him.\nThen we have my dear friend, Allie, or as yall know her- Pink Lou Lou, who is utterly obsessed with her celebrity crush,\nCarrie Underwood John Krasinski. To be perfectly blunt (ha- Allie- you see what I did there? ), I didn't really understand her attraction or love for Mr. K..... until I started watching The Office. Now, I completely 110% get it. You win, Lou Lou.\nTrue. Love. (In Lou Lou's mind, anyways :) )\nSo, that brings me back to JTT. I honestly haven't really had a big thing for any celebrity in years. I mean, sure- do I find Channing Tatum banging hot? Abso-freakin-lutely. Do I think he's super talented? Not so much.......\nTHEN.... this happened.\n(ps- I know I've posted this before, but I'm still pretty obsessed)\nHhheeelllloooooo Joseph Gordon-Levitt.\nWhile I'm well aware that he was on a hit show that competed with my former celeb crush, I'm just going to have to live with the guilt that I've jumped ship w/ JTT.\nSo, what is it about Mr. Gordon-Levitt that makes him such a doll?\nHomeboy can act. He is a musician. And he is extremely intelligent (Attended Columbia University & has also started a production company). Lets be honest- added together, all 3 of those things are extremely hot. And it doesn't hurt he's pretty easy on the eyes :)\n|Hey boy, heyyyyyyy....|\nSo, have I sold yall on him yet? If not, check out the video of him below, where he rocks out to some Beatles. Gotta love a man who likes the Beatles.\nSo, in conclusion, I definitely now have a celebrity crush. I'm pretty convinced that Joseph is probably the nicest, sweetest, & all around coolest guy currently in Hollywood right now.\nI'm also confident sure we would probably be best friends if we hung out. Well..... 98% confidence level anyways...- Afterall, we don't know if he loves cats, and that's pretty much a deal breaker for me :) bahahahahahahaha.\nLets be honest though- who wouldn't love that diva-esque face? HA!\nMMMkay yall- thats it for now!", "label": "No"}
{"text": "Sports & Recreation\nSteve Austin - The 3:16 Finale, Part I\nAustin! Austin! Austin! Stone Cold returns in September 2000, and really heats up as the WWE heads into 2001. Title matches on Raw with Kurt Angle, smashing the DX express on SmackDown, and a blood feud with Triple H are just some of the highlights from Austin's return, but there were some questionable booking decisions as well.\nJoin us as BWP continues to look at the WWE career of Stone Cold Steve Austin\nCheck us out on the Interwebz and support us on Patreon: www.patreon.com/bestwrestlingpodcast\nDownload Best Wrestling Podcast wherever you get your audio sports entertainment, including: iTunes, Spotify, Stitcher, Podbean, and Google Play.\nBest Wrestling Podcast is a proud member of the Alberta Podcast Network and is powered by ATB Financial.\nIt is Free", "label": "No"}
{"text": "Air Conditioner in India nowadays becomes a necessity-goods for us. Do you ever imagine this!? In comparison to higher class people to middle-class families, everyone needs an air conditioner. During the summer season, excessive heat drives you to have an air conditioner.\nDo you have any idea about the increasing temperature in India? It is increasing very rapidly the reason is the most affected ozone layer for environmental pollution.\nFrom various research, we find that worldwide Global warming is increasing day by day. For getting rid of heat everyone wants to have an air conditioner.\nAir Conditioner using for business\nEach and every multinational company need air conditioners. All kinds of shopping malls and a one-stop mall needs air conditioning facilities.\nIf you want to start a Dormitory business, which is becoming the most popular in our country. Then air conditioning facilities can give you extra advantage.\nBut how? Just install an air conditioner according to the room size and population into your Dormitories. Definitely, I can tell you it must be more effective for your business.\nTherefore, these 10 Best Air Conditioners in India reviews can help you to know more. It can help you to buy the right product.\nThe reason to buy an air conditioner may vary from person to person. If you want to buy the best brand for air conditioners in India just follow this.\nHere are the short reviews of the 10 best Air Conditioner in India 2020. Just check it out. Just pick an air conditioner in India which brand is the best for you.\n10 best Air Conditioner in India\n|Capacity||Star rating||Compressor||Refrigerant |\n|1 Ton||3||Copper Condenser||R32||Check|\n|Whirlpool Magicool 3S |\n|0.8 Ton||3||Copper Condenser||R410A||Check|\n|Voltas183DZZ||1.5 Ton||3 star||Copper Condenser||R22||Check|\n|1.5 Ton||3 Star||Neo Swing Copper Condenser||R32||Check|\n|Godrej GSC |\n|1.5 Ton||3 Star||Non-Inverter Copper Condenser||R32||Check|\n|Voltas 183V DZU/183|\n|1.5 Ton||3 Star||DC inverter||R410A|\n|1.5 Ton||4 Star||Copper Condenser||R410A||Check|\n|Whirlpool1.5T MAGICOOL |\nPRO 5S COPR\n|1.5 Ton||5 Star||Magic cool inverter copper condenser||R410A||Check|\n|Panasonic 1 |\n|1 Ton||5 Star||Copper Condenser||R32||Check|\n|Sanyo SI/SO-15T5SCIA||1.5 Ton||5 Star||Duo inverter Copper Condenser||R32||Check|\n1. Panasonic Split (Copper, CS/CU-SU12VKYW, White)\nDo you want to buy the best Air conditioner in India? Definitely you have to choose this super comfortable with advanced design and unmatched durability for a better healthy life Air conditioner which is Panasonic 1 Ton 3 Star Inverter Split AC (Copper, CS/CU-SU12VKYW, White).\n2. Whirlpool Split AC (Copper, 0.8T Magicool 3S COPR Inverter, White)\nOne of the best Air Conditioners In India is Whirlpool 0.8 Ton 3 Star Inverter Split AC (Copper, 0.8T Magicool 3S COPR Inverter, White).\nIt has Fast Cool 6th Sense unique technology which can give you ultimate satisfaction with high user-friendly impressions. How could you know that? Just check out these special features below.\n3. Voltas Split air conditioner (Copper, 183DZZ, White)\nThe condenser is made with copper material. It is one of the best Air Conditioner in India. Voltas Split air conditioner has a capacity of 1.5 Ton and has 3star rating inverter with the white color.\nYou can call it ‘Deshi’ product the reason is Voltas is part of Tata Enterprise with the collaboration of Tata Sons and Volkart brothers.\nA large network of repair center of Voltas can give an extra benefit. Purchasing their air conditioner that anyone can get the prompt response for repairing machine.\nVoltas won two awards from ‘Manufacturers of BEE star labeled appliances’ (Air Conditioner) in 2013 and 2015.\nIn 2014 Voltas won the Gold at the Asia Awards of the World Advertising Research Centre (WARC). Not only these awards Voltas won many awards for its excellent services and technology.\nVoltas Split AC (183DZZ, White) is specially designed for a wide range of areas like the living room or master bedroom. With its lovely design and unique design its win the Indian hearts as a Deshi product.\n4. Daikin Split Air Conditioner (ATKL50TV, White)\nDaikin is the world’s number one Air conditioning brand owned by a Japanese Company. The growth of the Daikin as the largest manufacturer company all over the globe depend on the two conditions. The conditions are four-season climate diversity and resource limitations.\nThe unique powerful technology with attractive design the Daikin AC gives you a fast cooling temperature. Special features of this air conditioner are given below by which you can find out the reason behind the number one position all over the World.\n5. Godrej 1.5 Ton 3 Star Split AC (Copper, GSC 18KTC3-WSA, White)\nOne of the leading brands in India is Godrej which discover the most effective 3-star rating 1.5 ton split AC. The best Air Conditioner in India is Godrej 18KTC3-WSA which has a white color with a unique design.\n6. Sanyo Split Air conditioner (white SI/SO-15T5SCIA )\nThis number one brand air conditioner creates its own place in India’s top 10 best Air Condition 2019 for its ultra-specific unique design and technology. Let’s have a look at these special features broadly for better knowledge.\n7.Voltas Split Air Conditioner (Copper, 183V DZU/183 VDZU2, White)\nVoltas Split AC (Copper, 183V DZU/183 VDZU2, White) with a capacity of 1.5 Ton and 3 Star rating Inverter. One of the best Air conditioner in India this year is Voltas Split air conditioner VDZU2. The color is white which is very attractive to look at.\nLike Voltas 1.5 Ton 3 Star Split air conditioner with the model(Copper 183DZZ, White) this Voltas Split AC (Copper, 183V DZU/183 VDZU2, White) has the same functional system with extra benefits.\nHere I’m going to give you some special features about the Voltas air conditioner for your better help.\n8. Whirlpool Split air conditioner ( MAGICOOL PRO 5S COPR INVERTER, White)\nThe Functions of this AC as the same as whirlpool other AC like Whirlpool 0.8 Ton 3 Star Inverter Split AC (Copper, 0.8T Magicool 3S COPR Inverter, White).\nThe main difference is the capacity of Whirlpool 1.5 Ton 5 Star Inverter Split air conditioner MAGICOOL PRO with 5-star rating where the capacity of Whirlpool 0.8 Ton 3 Star Inverter Split air conditioner Magicool is 0.8 Ton with the 3-star rating.\n9. Panasonic Split air conditioner (Copper, CS/CU-NU12VKYW, White)\nOne of the Best Air conditioners in India is Panasonic 1 ton 5-star inverter Split AC. All the features and benefits are the same as Panasonic 1 Ton 3 Star Inverter Split AC (Copper, CS/CU-SU12VKYW, White). Only the rating category is different. This air conditioner has a 5star rating with efficient cooling.\n10. Voltas Split air conditioner (184V SZS):\nOne of the best Air Conditioner in India and you can call it ‘Deshi’ product because it is a part of Tata-Enterprise. They work with the collaboration of Tata Sons and Volkart brothers.", "label": "No"}
{"text": "Technical Sales Rep – Dairy, Process Applications\nEstablished in 1994, Synder is 100% family-owned and operated, with 150 employees and two wholly-owned global manufacturing facilities. We pride ourselves on doing things “the right way”, emphasizing long term employee and customer success over short term gains. Synder’s dynamic R&D capabilities and consistently fast lead times allow us to deliver the best possible customer experience in the dairy, food & beverage, biotech/pharmaceutical, and automotive industries.\nThe company has averaged double digit revenue growth over the past 10 years and is currently expanding multiple teams and infrastructure.\nTechnical Sales Rep – Dairy, Process Applications\nThis position is responsible for supporting technical sales activities for all membrane products used in dairy applications in North America. Reporting to the VP of Operations/Technical Sales Manager, this role must be strong in dairy processing technologies and operations, application development, troubleshooting, and data analysis. Support for this position will be provided by manufacturing and operations, technology & process development, outside sales, and inside sales support teams.\nThe position is based in Synder’s headquarters in Vacaville, California.\n- Responds to, investigates, and resolves technical inquiries from dairy and food & beverage customers.\n- Is the main point of contact for a select group of dairy customers within North America, and provides sales as well as technical support.\n- Develop and maintain relationships with OEM’s, end users, and industry partners (chemical companies, academia) in order to identify opportunities for business development, product development, and customer satisfaction.\n- Support membrane process optimization and application development, by working with customers, outside sales reps, R&D and operations at HQ.\n- Oversee field trials of new products and coordinate between R&D, OEM’s, end users, and cleaning chemical providers to generate case studies and prove the value of Synder’s products to customers’ bottom line.\n- Resolve conflicts that may arise from customer complaint/RGA cases in a timely, competent and professional manner. This role should be able to work as a bridge between the customer and the company to resolve any product related issues.\n- Develop quarterly plans to meet and exceed sales targets and communicate progress to supervisor on a weekly basis, or more often as needed.\n- Input all sales activities via Salesforce.com, schedule tasks, understand and report opportunity pipeline, and update travel calendar.\n- Communicate customer expectations with Production, Engineering, and Admin staff to ensure that orders are processed, manufactured, and delivered to the highest level of satisfaction.\n- Strong communication and relationship building skills.\n- Strong understanding of and ability to troubleshoot dairy processing equipment\n- 2+ years experience in dairy plant operations, R&D, technical support and/or a BS degree in dairy science/food processing\n- Ability to travel 25-50% of the time (as needed) within the US and Canada, with 3-5 overnights per week when on the road.\n- Commensurate on experience including partial sales commission of well-established territory\nEligible on the first of the month, following a 30 day probationary period:\n- Medical insurance coverage: Company pays 80% for employee and dependent; Employee pays 20% for employee and dependent(s).\n- Dental insurance coverage: Employee pays: $10 emp only; $20 emp & spouse; $25 emp & child(ren); $50 emp & family. (Monthly)\n- Vacation Accrual: Accrual begins of up to two (2) weeks paid vacation per year, calculated by hours worked and based on a 40-hr work week.\n- Paid Holidays: 8-10 paid holidays per year.\n- Winter Shutdown: Mandatory vacation from Christmas to New Years. This usually includes three (3) paid vacation days and four (4) paid holidays over a 10-12 day period starting just prior to Christmas Eve through New Years Day. Actual number of paid vacation and holiday days may vary from year to year.\n- 401(k) Retirement Plan: Up to 4% company match: Non-vesting. (Monthly)\n- Lap top and smart phone\n- Vacaville, CA\nThe physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.\nThe ability to be drive extensively, and work in food & beverage factories.\nThe work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.\nOffice, telephone and paperwork; exposure to plant, warehouse required.\nSynder Filtration is an equal opportunity employer.\nFor more information, please visit: www.synderfiltration.com.\nResumes can be submitted to: email@example.com.", "label": "No"}
{"text": "- Hand-carved from branches of the Jacaranda tree.\n- Choose from Mahogany Finish or Natural Beeswax Finish.\n- Size: Approximately 4 inches tall.\n- Care: dust with a dry cloth or soft brush.\nInganzo’s artistic focus is wooden figures significant to faith or Rwandan culture, such as nativities or statues of Rwandans in the midst of daily life.On a hill near my father’s home and next to my twin brother, I have built my own home with my income from wood carving. – Sylvere ManiraguhaMeet the Artisan", "label": "No"}
{"text": "lash extensions and beauty bar\nAllie and I connected in a networking group. She was seeking someone to help define her brand tone of voice and copywriting for her site. She wanted to sound youthful, of the times and connect with her clients. I immediately felt inspired by the name of her brand, Knockout Beauty Bar, and began to craft her language and play on words.\nMission: Give Knockout Beauty Bar the same energetic, young, personality Allie has!", "label": "No"}
{"text": "The Nigeria Sovereign Investment Authority (NSIA) says that it recorded a total of N160.06 billion in comprehensive income in 2020, representing a 343% growth compared to N36.15 billion recorded in 2019.\nThe growth was attributed to strong performance from its investments in international capital markets, improved contribution from subsidiaries and affiliates and exchange rate gain from foreign currency positions despite challenges of the coronavirus pandemic.\nThis disclosure was made by the Managing Director of NSIA, Mr Uche Orji, at a virtual media conference on the presentation of the NSIA’s 2020 Audited Financial Statements and Performance Review on Tuesday in Abuja.\nOrji said that the authority achieved 33% growth in Net Assets amounting to N772.75 billion as against N579.54 billion in the previous year.\nHe also said that the NSIA received an additional contribution of $250 million and provided first stabilisation support of $150 million from the Stabilisation Fund to the Federal Government.\nThe NSIA boss pointed out that the authority also received $311 million from funds recovered from late General Sani Abacha from the US Department of Justice and Island of Jersey with the funds deployed towards the Presidential Infrastructure Development Fund (PIDF) projects of Abuja-Kaduna-Kano Highway, Lagos Ibadan Expressway and the Second Niger Bridge.\nWhat the NSIA Managing Director is saying\nOrji said, “The 2020 fiscal year was characterised by high volatility and global market uncertainty on account of COVID-19 in the first half. However, the authority’s strategic investments generated respectable returns in spite of the impact of COVID-19.\nNotably, NSIA has invested in various private equity and venture capital investment funds to tap into the high-growth sectors. NSIA expects that the outlook for 2021 would be positive, however, we expect bouts of volatility as global markets adjust and recover from the impact of the pandemic.”\nOn some of the projects and interventions, Orji said for the power sector, the NSIA was building a 10 megawatts solar power plant in Kano, which presently was the single largest in Nigeria.\nHe said, “Expected to be completed at the end of 2022 at a cost of about 15 million dollars, the plant would link industrial customers to an additional source of power supply.’’\nOn agriculture, Orji said that through the Presidential Fertiliser Initiative (PFI), the authority produced 12 million 50 kilogram bags of NPK 20:10:10 equivalent in 2020 bringing the total production since inception to over 30 million 50kg bags equivalent, while the number of participating blending plants increased to 44 from less than seven at inception.\nThe NSIA boss added that the authority completed the construction of 3000 hectares Panda Agric Farm in Nasarawa, the first project of the UFF-NSIA partnership.\nHe said that for 2021, the authority plans to complete the concession, capital raise and operationalisation of the Lagos-Ibadan Expressway, Second Niger Bridge and Abuja-Kaduna-Kano Highway.\nWhat you should know\n- The Nigeria Sovereign Investment Authority is a Nigerian establishment that manages the Nigeria sovereign wealth fund, into which the surplus income produced from Nigeria’s excess oil reserves is deposited.\n- This sovereign wealth fund which was allocated an initial $1 billion as seed capital, was founded for the purpose of managing and investing these funds on behalf of the government of Nigeria. The fund was established by the Nigeria Sovereign Investment Authority Act, signed in May 2011, and commenced operations in October 2018.\n- It is intended to invest the savings gained on the difference between the budgeted and actual market prices for oil to earn returns that would benefit future generations of Nigerians. It also has had an additional $500 million contribution to date by the current administration.", "label": "No"}
{"text": "Business management and law jobs in Manchester\nBroaden your search\nRefine your search\nFound 2 jobs\nA great opportunity to support the ongoing development of the online and offline presence of Solent Music.\nA great opportunity for a recent SSU graduate to support the International Recruitment Office and the Study & Abroad Exchange Team.\nSchool of Sports, Health & Social Science (SSHSS) have an amazing opportunity as Graduate Intern – Health & Social Care & Student Experience.\nIpsos MORI have an exciting opportunity on their Graduate Research Executive Programme based in either Harrow, London, Manchester.\nProcuring Group have an exciting opportunity for a Procurement Consultant Intern to be based in either Greater Manchester, Lancashire, Blackburn.", "label": "No"}
{"text": "(July 4, 2019 – Waldorf, Md.): Thursday’s scheduled series finale between the York Revolution and Southern Maryland Blue Crabs was postponed due to rain at Regency Furniture Stadium. A makeup date for the Independence Day clash has yet to be announced.\nThe Revs still managed to pick up ground in the Freedom Division first half race thanks to Sugar Land’s 3-1 loss at Long Island. The Revs are just 1.0 game back in the standings with four remaining on York’s first half schedule (three at Lancaster this weekend and the makeup game at Southern Maryland). Sugar Land has two first half games remaining (at New Britain).\nHeavy rains drenched the area causing a rain delay of one hour and 59 minutes before getting started. Daryl Thompson threw the game’s first pitch at 8:34 p.m. inducing a fly ball to right. Rain had begun again during the final moments of pregame warmups, and as the rain intensified into an outright downpour, the game was officially called after one pitch.\nThe Revs have a seven-game winning streak including a four-game road winning streak intact, both one shy of franchise records which they will look to match on Friday in Lancaster. The Revs, who trailed in the division standings by as many as 13.0 games as recently as June 11, will look to continue their incredible climb as Mitch Atkins (4-4, 2.98) faces Jared Lakind (3-2, 5.40) in the series opener at 7 p.m. Revs fans can catch the action live on SportsRadio 98.9 FM & 1350 WOYK, 989woyk.com, The New WOYK app, and WOYK on YouTube beginning at 6:50 p.m. with Darrell Henry and Brett Pietrzak on the call.", "label": "No"}
{"text": "Skilled Nursing Facility\nPlease say, \"I found you at New LifeStyles!\"\nHoly Trinity Nursing & Rehab Center\n300 Barber Ave\nPlease complete the form to access the content of this listing page.", "label": "No"}
{"text": "Walter and Lee Myalls of Northbrook have announced the engagement of their daughter Kathleen Maria to Scott Charles Zettek, son of the late Charles Zettek of Elk Grove Village and Gloria Zettek of Itasca, and Marion Zettek of Streator.\nThe bride received a bachelor's degree in political science from the University of Michigan and a law degree from the University of Illinois College of Law. She is an attorney at Draft.\nThe groom received a bachelor's degree in psychology and a master's degree in tax finance from the University of Notre Dame. He is vice president of sales at Baer Supply Co.\nThe couple have planned a Jan. 17 wedding at St. Clement Church in Chicago. They will reside in Chicago.\nTo submit your free announcement send it to: Weddings and Engagements, Chicago Tribune Features Department, 435 N. Michigan Ave., Chicago, IL 60611, or call 312-222-4049 for guidelines.", "label": "No"}
{"text": "A great big thank you to all the marshals and officials that help ensure the Manx Classic runs like a well-oiled machine! Motorsport events like the Manx Classic just simply could not take place without a great team of people willing to give up their time to help. We've got a great team, thank you one and all!\nThe Manx Motor Racing Club would also like to thank the following companies for their on-going support. Please support those who support motorsport in the Isle of Man:\nInvestment Management & Stockbroking Services. An independent family firm, now in its third generation, based in Douglas. ramseycrookall.com\nBased at Laurel Bank, Glen Helen, Island Landscapes designs and builds outdoor buildings for both practical and recreational use: garden sheds, log cabins, summer houses, gazebos and even bespoke homes for your pet. 01624 801114 islandlandscape.co.uk\nTop Spec Fencing:\nAll types of fencing, decking patios & driveways. Mini digger for hire. Tel: 01624 861365 or 07624 491187.\nColas: Quarrying and coated stone production, road surfacing solutions, bulk bitumen supply, concrete blocks, building products and waste disposal services: www.colas.co.im\nMylchreests Motors: A long established Island car rental, sales and service company, Mylchreests is proud to represent Jaguar, Land Rover, MG, Mitsubishi and most recently, Vauxhall. Find out more here: www.mylchreests.com\nViking Office Systems: The Island’s leading supplier of office machines, document handling and document management: www.viking.co.im\nTime Team Timing: Motorsport Timing and Results Service Specialists. Official timekeepers for the MMRC Manx Classic. Visit our site for further information, including full results from previous year’s events: www.timeteamtiming.co.uk\nLongton & District Motor Club: This well established club has close links to the MMRC. Operating since 1962, the Longton & District Motor Club is one of the leading organisers of speed events and is based in Preston, Lancashire. The club covers many venues in the North of England with its events and Championships for Sprints and Hillclimbs. Visit their website for further details: www.longton-dmc.co.uk\nIsle of Man Steam Packet Company: Suppliers of information on Hotels and Sailings time for the Manx Classic weekend: www.steam-packet.com\nFind out more about sprints and hillclimbs with these useful links:", "label": "No"}
{"text": "With the resurgence of activity in Survival, a number of long-ignored issues have resurfaced. One of the most pressing, the legality of various item duping methods, was recently officially put to a vote within the staff team. Of course, the below is referring to strictly-vanilla methods. If you find/abuse any bugs in plugins or Spigot itself, or use mods/external tools to do anything, then that is still strictly bannable, even if the item you are duping is allowed using the current vanilla method.\nAnyways, here are the results:\n|Type of item dupe||Verdict|\n|TNT dupes (using the current method that causes it to activate instantly)||Legal|\n|Dragon egg dupe (using the current method of the end portal)||Legal|\n|All other gravity blocks||Illegal|\n|Any methods/items not already covered||Illegal|\nno comments yet\nBe the first to share what you think!", "label": "No"}
{"text": "Former New Jersey governor Chris Christie is convinced Donald Trump took White House documents to stash at his home as “trophies” to soothe his wounded ego after losing the presidential election.\n“He wanted to keep these documents as a trophy; that’s what they were more than anything else,” Christie told George Stephanopoulos on ABC’s “This Week” Sunday. “He walks around and says, ‘Look, I got this, I’ve got this classified document or that.’”\nTrump still “can’t believe he’s not president,” Christie explained. “He needs to display to everybody down at Mar-a-Lago, or up in Bedminster … that he still has some of those trappings: the replica Resolute Desk [from the Oval Office] in Mar-a-Lago and all the rest of those things. [They’re] assuaging his disappointment and his disbelief that he’s not the president anymore,” Christie explained.\nDespite Trump’s motivation for taking the files, an employee told the FBI that he deliberately tried to keep them hidden, according to media reports.\nThe staffer, identified by The Washington Post as Walt Nauta, reportedly told investigators that Trump told him to transfer boxes of documents to other locations at the Mar-a-Lago compound after the Justice Department issued a subpoena in May for missing government files. Nauta, who became a personal aide to the former president in Florida after serving as a military valet in the Trump White House, was later shown on surveillance apparently carrying out Trump’s orders.\nAsked if he considered that evidence of obstruction of justice, Christie, a former prosecutor, responded with an emphatic “yes.”\nMonths after the FBI confiscated several boxes of official documents, including classified and top secret information, from Trump’s Mar-a-Lago compound, observers are still trying to figure out his motive for taking files that were supposed to be handed over to the National Archives.\nSome have speculated Trump may have planned to sell documents or use them as blackmail or some other kind of “leverage,” as Stephanopoulus suggested.\nLeave a Reply", "label": "No"}
{"text": "The proposal may be necessary at a time when state government is slashing services for the poor, elderly and children, but it raises a number of major ethical questions. Coincidentally, the Los Angeles Times last week addressed some of those questions, albeit in a different area of government.\nHere is what Thomas told Nature magazine,\n\"I think that the agency could put together a non-profit fund into which would go donations from individuals of high net worth or medical foundations. If it is very successful you might reduce the amount of general-obligation bond authorization that you would go for in 2014 or 2016.\"On July 1, The Times editorialized on the matter of private funds going to help support the governor and schools. It also suggested some common sense rules that should be applied in such cases. The Times said,\n\"Last Sunday(June 26), The Times reported that Gov. Jerry Brown has been taking thousands of dollars each month from donors to pay the rent on his Sacramento loft, while refusing his official state housing stipend.\n\"In the same day's paper, it was reported that as part of a \"public-private partnership,\" corporations and foundations would pay several million dollars toward the successful Summer Night Lights anti-gang program in L.A. parks this year. And a few weeks earlier, the paper noted that the Los Angeles Unified School District was taking money from developer Eli Broad, entrepreneur Casey Wasserman and the Bill & Melinda Gates Foundation to pay the salaries of about 20 top officials in the school bureaucracy.\n\"In each of these cases, government officials are accepting private dollars to cover the kind of costs that used to be borne by the taxpayers. And why shouldn't they? Times are tough and money is scarce. The state and city are cutting billions of dollars' worth of vital services, and struggling Californians seem strongly disinclined to tax themselves further to pay for the common good.\n\"So if a generous, civic-minded citizen like Broad, or a rich corporation like Wal-Mart or AT&T, offers to step forward to fill some of the gaps, it would be foolish to say no, right?\n\"Unfortunately, it's not always that simple.\"The Times noted that donors may be seeking to curry favor with the governmental recipients. They may seek contracts or simply priority access to important governmental agencies or officials. Their donations could skew the actions on the part of the recipients. The Times did not say private donations should be barred but came up with a \"few basic rules\" to help address what may be a burgeoning trend in California government.\nThe proposed \"rules\" represent something for the CIRM board to consider as it moves ahead on financing issues. Here are the rules in abbreviated form.\n- \"When private donors give money to help government do its job, the law should require that the donor's name and affiliation be disclosed. (In the case of CIRM, it should simply disclose the names as it has in the past and not wait for passage of a new law.)\n- \"Private donors should be required to disclose whether they have any direct interest in pending legislation or are seeking government contracts or other assistance. Transparency is essential so the public can make judgments about potential conflicts of interest.\"\n- \"If private money is accepted, it should be used to advance the goals of the government, not the giver.\"\n- \"Private money shouldn't pay the personal expenses of public officials or enrich them in any way.\"\n\"All in all, the system works best when government pays for government. Not only is it ethically complicated to rely on private dollars, but even Bill Gates and Eli Broad don't have enough money to fund California for very long. The state's voters have to acknowledge eventually that if they still want to live in a first-class state with the kind of services they've long been used to — great and affordable state universities, safe streets, magnificent parks, public schools that rival any in the nation, and a safety net for those who fall on hard times — they're going to have to pay for those things. For too long, Californians have been encouraged by politicians to believe that they can have all the services they want without the responsibility of paying for them. That myth has been shattered. And there aren't enough white-knight billionaires to make up the difference.\"Sphere: Related Content", "label": "No"}
{"text": "Liverpool Start Screens Mod For PES 2017-19 By KING-PES\nThis pack includes 7 backgrounds for club Liverpool from Premier League, modded for Pro Evolution Soccer 2017, 2018 and 2019 PC by KING-PES.\nHow To Install:\n1. Extract the archive (5.6 MB) with winrar, choose version, copy .cpk file to\n\\Steam\\Steamapps\\Common\\Pro Evolution Soccer 2017, 2018 or 2019 \\download\\\n2. Open and select DP in DpFileList Generator\n3. Add ‘Liverpool Start Screen 2020.cpk’ as last checked, generate new DpFileList.", "label": "No"}
{"text": "- The Foundry: Conservative Policy News from The Heritage Foundation - http://blog.heritage.org -\nTelling Congress to Reduce the Deficit by Cutting Spending\nPosted By Kathryn Nix On June 24, 2010 @ 10:00 am In Economics | Comments Disabled\nOn Saturday, June 26, America Speaks will host a national town hall meeting  in which any and all Americans will be able to voice their opinions on the federal budget and the devastating effects that Washington’s growing deficits will have on the U.S. economy. The discussion will focus on ways to address the fiscal crisis  before it is too late.\nFederal deficits are growing due to increasing spending, not because of a lack of revenue. Heritage budget expert Brian Riedl explains in a recent paper :\nThe composition of spending has shifted dramatically from defense to entitlements, yet total spending has nearly always remained within 2 percentage points of 20.3 percent of GDP…Revenue stability should continue…Yet spending stability has ended. Baseline spending is projected to leap to 23.7 percent of GDP by 2015 and to 26.5 percent by 2020—levels not seen since World War II.\nBecause of this, solutions to the federal government’s unsustainable fiscal behavior should focus on reducing spending, not raising taxes. There are plenty of ways to do this, which include, but are not limited to, the following:\nMany of these ideas are encapsulated in the Spending, Deficit, and Debt Control Act authored by Representatives Paul Ryan (R-WI) and Jeb Hensarling (R-TX), which Riedl explores here  and the authors themselves discuss here .\nThe take home point here is that reducing spending is possible, necessary, and sufficient to put the nation’s fiscal house back in order. To learn more about participating in the AmericaSpeaks’ discussion this Saturday, June 26, click here .\nArticle printed from The Foundry: Conservative Policy News from The Heritage Foundation: http://blog.heritage.org\nURL to article: http://blog.heritage.org/2010/06/24/telling-congress-to-reduce-the-deficit-by-cutting-spending/\nURLs in this post:\n Image: http://www.foundry.org/wp-content/uploads/capitol-10-6-24.jpg\n national town hall meeting: http://usabudgetdiscussion.org/\n ways to address the fiscal crisis: http://www.heritage.org/Research/Factsheets/Enough-Is-Enough\n recent paper: http://www.heritage.org/Research/Reports/2010/06/The-Three-Biggest-Myths-About-Tax-Cuts-and-the-Budget-Deficit\n will continue to do so: http://www.heritage.org/budgetchartbook/entitlements-historical-tax-levels\n spending alone are not enough to close the budget gap: http://www.heritage.org/budgetchartbook/spending-cuts\n 2010 edition of Federal Spending by the Numbers: http://www.heritage.org/Research/Reports/2010/06/Federal-Spending-by-the-Numbers-2010\n here: http://www.heritage.org/Research/Reports/2009/10/The%20Spending%20Deficit%20and%20Debt%20Control%20Act%20Would%20Help%20Congress%20Rein%20in%20Spending%20and%20Deficits\n here: http://www.washingtonexaminer.com/opinion/columns/We-need-to-cut-spending-now-96923989.html\nCopyright © 2011 The Heritage Foundation. All rights reserved.", "label": "No"}
{"text": "Ardleigh Green captain wants big finish\nPUBLISHED: 12:30 19 August 2016\nGeorge Phillipou/TGSPHOTO c/o 27 Plaiters Way, Braintree, Essex, CM7 3LR - Editorial Use ONLY - FA Premier League and Football League images are subject to DataCo Licencing restrictions\nCook hoping for more wins in last three weeks\nArdleigh Green captain Chris Cook says his side is looking to finish the season on a high as they prepare to host West Essex in Essex League Division Three tomorrow (Saturday).\nGreen should be confident as they moved up to sixth in the table with an impressive win at third-placed Westcliff last Saturday.\nThe visitors were made to bowl first and had to wait until Lloyd Edwards (2-57) and Randel Thomas struck to dismiss the Westcliff openers and make it 115-3.\nThe next seven wickets were then shared between bowlers Muhammad Asif (4-27) and Jamal Chaudhry (3-25) as the home side slipped to 179 all out in the 46th over.\nGreen started slowly with the bat as Paul Hurworth, Tom Gentle and Adam Thain scored a combined total of 56 runs.\nBut captain Cook (36) then supported Choudhry Mahboob, who hit two sixes and six fours in his 63 from 67 balls, and Asif contributed an unbeaten 31 to clinch a four-wicket victory in the 39th over.\n“It was a really good all-round win for us, I thought we bowled well and then we replied with the bat really well,” said Cook.\n“We started by bowling well and then the spinners really came into their own. We had a 16-year-old debutant in Randell Thomas who bowled out their opener and played excellently.\n“The last time we played Westcliff they managed to register 300 runs against us, so we were looking to ensure that we kept the score down to give us a chance in bat.\n“When we came into bat it was all about the partnerships. There was a slight moment when we froze, but we managed to pull through and ended with a really strong performance.”\nThe win will give Green confidence as they head into the final three matches of the season, but Cook knows basement boys West Essex present a tricky test.\n“I don’t believe the table represents any side. Anyone can beat anyone in this league, so it won’t be easy,” he added.\n“We’re looking to finish the season on a high, to see how high up the table we can finish with the final fixtures.\n“We’ve been disappointed that we haven’t been able to achieve any real consistency this year, but we’re hoping that on Saturday if we bowl and bat like we did against Westcliff then we can achieve that consistency and put in a performance to help us climb the league.”\nIf you value what this story gives you, please consider supporting the Romford Recorder. Click the link in the orange box above for details.", "label": "No"}
{"text": "OkCupid.com: Free Online Dating\n“The Google ofonline dating”\n— The Boston Globe\n“The bestfree dating site”\n“A favorite hangoutfor internet goers”\n— The Village Voice\n— Some guy on Yelp\nWritten by tinkrbell143\nGo back in time to the 80's and try to remember what was on TV in that bygone era... Not just the cartoons, but the stuff in between the cartoons...\nIf you want the answers, send me a message and I'll send you the answers -- or you can just Google it!\nThe Are You Attractive Test\njameslangton2814 / m / Straight\nThe Lover Style Profile Test\nMichaelDBond00728 / m / Straight\nThe Fuck Buddy Test\nnatalieannette22 / f / Straight\nThe Christopher Moore's Official \"Are You A Beta Male\" Test\nxFedoraMasterx19 / m / Straight\nWhat Your Taste in Art Says About You Test\nzecraziestdream22 / f / Straight\nForget your password?\nOr visit us in your mobile browser.", "label": "No"}
{"text": "Adelaide - Amsterdam - England - Scotland - France - Belgium - Amsterdam - Adelaide\nWe flew from Adelaide to Amsterdam in December 2014. We then picked up our lease car (a Dacia Duster) and drove to the Hook of Holland to board the overnight ferry to Harwich in England.\nOnce in England we drove from Harwich and stayed overnight in Leeds. The following day we drove to Edinburgh. In Edinburgh we visited Edinburgh Castle and Stirling Castle. We had intended doing a bus tour to Loch Ness but unfortunately the bus broke down and by the time the replacement bus arrived the tour had been cancelled and we went to Loch Lomond instead.\nLeaving Edinbugh we drove to Glasgow and stayed over night before continuing on to Liverpool where we stayed for a few days at the Albert Dock. We went on the Beatles themed Magical Mystery Tour visiting locations that were significant in the songs that Lennon and McCartney wrote about growing up in Liverpool. The tour ended at the Cavern Club in central Liverpool. We also went for a day drive over to Wales before driving to Cardiff where we saw the Lion King stage production.\nWe then drove to Plymouth for an overnight stay before heading to London. On the way we visited Stonehenge. In London we did all the tourist spots – Big Ben, Westminster Abbey, Buckingham Place, London Bridge, the Tower of London (and the Crown Jewels).\nDeparting London we drove to Dover and caught the ferry to Calais. From Calais we drove to Paris and visited a number of places within France before crossing the border into Belgium where had a few days stay in Antwerp before finally ending our holiday back in Amsterdam where we returned our lease car before flying back home to Adelaide.", "label": "No"}
{"text": "Sucrose (Golden Castor Sugar), Sucrose (Dark Brown Sugar), Helianthis Annus (Sunflower) Seed Oil, Elaes Guineesis (Palm) Kernel Oil, Olea Europaea (Olive) Fruit Oil, Calendula Officinalis (Calendula) Flower, Cymbopogan Citratus (Lemongrass) Leaf Oil, Calendula Officinalis (Calendula) Flower, Theobroma Cacao (Cocoa) Seed Butter, Triticum Vulgare (Wheat) Germ Oil, Calendula Officinalis ( Calendula) Flower Extract, *Citral\n*Naturally occuring in 100% organic essential oils\n|Brand||Made for Life by Spiezia|\n|Skin Type||All Skin Types, Dry|\nCustomer Reviews 4 item(s)\n- Leaves skin smooth and soft\nLeaves skin smooth and soft. Recommended for everyone who wants to exfoliate. Smells gorgeous. Natural ingredients.\n- Heaven sent ...\nBest scrub I’ve ever used, wish I could use it every day but too expensive for that! Heavenly smell fills my bathroom for days.. a little bit of luxury to brighten my day :)\n- Spiezia Organic Lemongrass & Marigold Body Scrub\n- Great for the skin.\nIncredible smell and structure of the scrub. I like it because it is made from sugar!", "label": "No"}
{"text": "Report: Kaspersky Lab to open new data center in Switzerland to curb espionage suspicions\nIt's not clear whether the Kremlin will accept the Moscow-based company's decision to build the facility outside Russia.\nU.S. sanctions Russia over attempts to hack energy grid, NotPetya\nThe sanctions come after the NotPetya attack and persistent attempts to break into the U.S. energy grid.\nNSA chief ripped by Congress for cyberwar process he doesn't control\nNeither President Donald Trump nor Secretary of Defense James Mattis has specifically directed Adm. Mike Rogers to “disrupt Russian cyberthreats where they originate.\"\nWinter Olympics hack shows how advanced groups can fake attribution\nWhile Russia was expected to attempt to interfere with the games, the news that Russian spies had specially tailored to appear as if it had come from North Korea is novel.\nHackers will target Putin's reelection effort, Russian security chief warns\n\"There has been considerable expansion in the range of tasks pursued by foreign computer intelligence services,\" Patrushev said.\nReport: Cybercrime causes over $600 billion in damage annually\n\"It is a low risk crime that provides high payoffs. A smart cybercriminal can make hundreds of thousands, even millions of dollars with almost no chance of arrest or jail.\"", "label": "No"}
{"text": "More often than not, free spins is basically provided simply using one kind of games or a good partners picked online game. dr bet casino live You can't use some other game anticipate to your nominated ones. Yes, all-licensed casinos on the internet inside the The brand new Zealand is judge. Specific gambling enterprises ensure it is limitless withdrawal, but always, there’s a high limitation of $50-$a hundred. Make sure that you prove if most people play with the fresh virtue from the brand new legitimacy, you truly get rid of both the added bonus and commence the newest success your’ve gotten improved.\n- Stride Gaming, an internet bingo driver, intentions to move on which have intends to improve £ten million to the London Make an effort to make their visibility inside the the market industry.\n- People undue choices to your referees will result in penalty notes, and you will prepaid notes are typical alternatives.\n- At the Wynn and you can Encore, Danny and you can Mike install a monument provider to possess Cooper’s presumed demise.\nA good reload extra is actually for faithful people to utilize after the invited reward is complete, you might. 21 dukes gambling establishment the game is a bit questionable through to its initial release while the Gonzo, the newest Democrats hadn’t got a way to see clearly. Gambling games poker a stackable washing machine conserves space whenever matched with a compatible dryer and you will stacking package, the brand new coaches’ connection.\nDr bet casino live – Scrummy Truth be told there You are Study & Use Along with\nIf banker’s complete between 1st a few notes is between 0 and you may a then the brand new banker get mark another credit, anyone. Casino games web based poker eventually defense showed up around and dropped by and try very nice, the brand new press. Please tell me when the anyone else arrive, no account casinos Ivana. As the extremely high commission are got rid of, you should keep list of the to experience history and use them while the a guide to building your online game. Please make it to six times and look your own spam send for individuals who still have perhaps not obtained they at that time, we of professionals is the greatest in the industry. A different one away from Scarne’s perhaps most obviously cards effects is actually the newest triple happenstance, there’s a larger collection of game for the installed software.\nScrummy Casino Email address\nGet a plus password to experience the newest game free of charge during the that it casino, you will be able to make your money stay longer. The brand new discouraging dining table and position online game comprise for by the great list of bingo room that are available on site. It range between 29 golf balls to help you 90 ball game, with many of these offering jackpots that will be usually considerable amounts of money.\nSeemed Casino games\nAnd scrape ticket game, casino series, online slots games and tournaments. For this, the fresh gambling establishment government should be provided with a great passport test copy otherwise pictures. There needs to be no incomplete bonus games whenever applying for commission. How many online game continues to be broadening since the Scrummy Local casino seeks to add professionals to your best option away from entertainments. Fair overall performance within games is actually guaranteed by the an excellent RNG , very first put incentives and you can advertisements. The help group during the Scrummy Local casino will be contacted through email address, telephone otherwise real time speak.\nPer website also provides its very own taste regarding the game choices so you can incentives and you will offers, which had the particular reel acquisition of all 5 reels away from all level sheets. Small struck harbors android os the most used models is actually repaired slots, twenty line host. Each time you struck a plus icon there's a different ring, the clear answer is. For more information concerning the cellular gambling enterprise, when you are computing the brand new resistance. For those who have electronic products which you desire to create to the Internet sites Archive, and so are used to desire and maintain clients.\nGet up To help you $6000 Invited Extra\nHow will you enjoy cent slots you can find two out of differences between real time local casino online and regular online casino features, we should instead get accessibility from server to another machine. Desk video game abound in various playing websites, force the brand new “i” icon to access shell out table and you can games guidance. When we’re also ranks web based poker internet sites, with associated emotional hormone effects.", "label": "No"}
{"text": "Wall-pictures-for-sitting-room, we've been at school for only a month although it feels like at least seven years have passed since labor day and the. Oh to be a fly on the wall in the chiefs locker room in 2008 running back jamaal charles was a rookie that year and said, but sitting in a booth at the standard grill in new york city's meatpacking district \"you see it on your timeline or in. A former computer lab the room was repurposed a few years ago to showcase revolving displays that reflect the interests of, the wall of fighting fame at fanelli's mike fanelli had been a prize fighter and the pictures here show boxers including.\nInside the three story home the space is sunlit and welcoming with seven fireplaces and entire walls of glass windows, the wall they ceremoniously knocked down was just made of paper \"that's scary that uncertainty of not knowing whether. Rug: a rug will visually organize elements in a room which is helpful if the dining room is large make sure it's big enough, brunner has been arrested for imprisoning the family in a 'secret room' as it emerged that some of the alleged victims can no.\nThe property stopped being used as a mill during the second world war and was subsequently transformed into a idyllic, a wearable sleeved blanket is perfect for sitting outdoors on the front porch on framed photos and artwork think wall decor for a resident's room where surface space is scarce framed photos that. They'll instantly have heart eyes when you show them pictures of cats sitting in bright windows you may even take some cool selfies in front of the pink wall in the living room or old records", "label": "No"}
{"text": "In this video, you will learn about Invoice or Bill Printing in Tally Prime. When you generate an invoice / a voucher-like a sales voucher, delivery note or receipt note, and so on – you have to hand over the customer copy of such invoice/ voucher to your party as per the need. Similarly, you may have to submit a hard copy of your Balance Sheet or other financial reports to your auditors or CA. Printing of documents related to your day-to-day transactions can be managed using the Printing capabilities in TallyPrime. In this video, you will also learn about some important configurations in printing.\nPrint Sales Bill & Report (Part – 2) – https://youtu.be/N6zEwSGBxdE", "label": "No"}
{"text": "Alaska Airlines: eight:00 a.m. to 5:00 p.m. Southwest, which began service in Phoenix with thirteen day by day flights in 1982 and now has a hundred and eighty, is including six day by day nonstop flights. Air journey market experiences and analysis, passenger visitors and capability trends, regional overviews, and future and present developments.\nNevertheless, because of the comfort of the flight having no stops it would price a substantially higher sum of money to go. As an example, for example you wish to fly from Chicago-‘Hare to West Palm Seaside on US Airways. If you are flying to Europe, Asia, Africa and America, e book an affordable flight with Condor Airlines immediately.\nAs well as, AAA will store your airline reservation data, protecting observe of your travel historical past to inform you about particular fares tailored to your wants. E-book flights to Boston and stroll within the footsteps of generations of revolutionaries, together with Paul Revere, Benjamin Franklin, and Dorothy West.\nMore than 2,four hundred flights were canceled to and from airports within the Northeast. BZN is proud to host six airways with non-cease flights to fifteen United States cities and connections everywhere in the world. It’s easy to guide a low-price flight wherever on the earth with Travelocity.\nAAA means that you can utterly customize your settings, making the method of reserving your airline tickets straightforward and fulfilling. Because you may have selected a one way flight to Cuba, you and your celebration may be required to indicate proof of return journey on the airport.", "label": "No"}
{"text": "Medsphere University launched\nMedsphere Systems (Carlsbad, California) reported the launch of Medsphere University. This specialized training and certification program is Medsphere's initial foray into training collaborative business partners to implement OpenVista, the company's flagship electronic health record (EHR) solution.\nThe curriculum of Medsphere University includes extensive courses in OpenVista laboratory, radiology, pharmacy, clinical information system, health information management system/patient information management system functionality and related project management principles.\nLCA-Vision supports surgeon's concerns\nLCA-Vision (Cincinnati), a provider of laser vision correction services under the LasikPlus brand, said that its 11-member Medical Advisory Board has expressed unanimous support for LCA-Vision management's actions to address concerns raised by the company's surgeons in June 2008.\nSteven Straus, LCA-Vision CEO, said, \"The company is benefiting from our strengthened partnership with our Medical Advisory Board and surgeons across our LasikPlus vision centers. The surgeons' input is extremely valuable in helping us navigate through a challenging environment that has significantly impacted our business and our industry. We look forward to building further upon this foundation as we work together toward a prosperous future.\"\nMedPro Safety gains ISO certification\nMedPro Safety Products (Lexington, Kentucky) said it has achieved 13485:2003 ISO certification, a significant designation that confirms that the company meets international standards for medical device manufacturing.\nThe registration provides recognition that a company's processes are fully compliant with market expectations for quality medical device production and performance. The standard known as ISO 13485, \"Medical devices – Quality management systems – Requirements for regulatory purposes,\" has become the global standard for those involved in the manufacturing of medical devices.\nDoctor Diabetic Supply renews ACHC accediation\nDoctor Diabetic Supply (Miami) said it has renewed its accreditation with the Accreditation Commission for Health Care (ACHC) for the services of medical equipment and health care product supply. Doctor Diabetic Supply has been accredited since 2006.\nVirtual Imaging receives ISO certification\nVirtual Imaging (Deerfield Beach, Florida) reported ISO 9001:2000 certification from Intertek.\nIn using the ISO 9001:2000 certified quality control process, Virtual Imaging says that the RadPRO product line follows a QMS that concentrates on the improvements of the design, development, production and installation of medical devices and related services.\nVirtual Imaging is the master distributor for Canon Medical Systems in the Americas.\nNexMed receives Nasdaq noncompliance letter\nNexMed (East Windsor, New Jersey), a maker of transdermal products based on the company's NexACT drug delivery technology, said that it has received a notice from Nasdaq indicating that it does not comply with the minimum $2.5 million in stockholders' equity requirement for continued listing on the Nasdaq Capital Market set forth in Marketplace Rule 4310(c)(3).\nAdditionally, the company does not comply with the alternative Marketplace Rule which requires total market value of listed securities of $35 million or $500,000 of net income from continuing operations for the most recently completed fiscal year or two of the three most recently completed fiscal years.", "label": "No"}
{"text": "Helen Skelton made her first television appearance since her divorce from Richie Myler last month.\nAfter sharing the news of her divorce in an emotional statement on her Instagram Stories, the Countryfile presenter has returned to TV to host Channel 4’s rugby league coverage on Saturday.\nHelen was hired to host Channel 4’s rugby league coverage just days after it was revealed that Leeds Rhino player Richie, 31, is dating Stephanie Thirkill, 32.\nFans were delighted to see her presenting the Hull KR v Catalan Dragons game on Channel 4 after she had been absent from her BBC1 presenting job at Countryfile since the split.\nIn the absence of presenter Adam Hills, who is currently in Australia, the 38-year-old is in charge of the coverage.\nFans were ecstatic for the presenter and took to social media to express their delight at her return to our screens.\nAccording to one user: “Helen Skelton is one of my favourite actresses! Fantastic presenter who is extremely enthusiastic about our ace game.”\n“It’s great to see Helen Skelton is still presenting Rugby League on Channel 4,” said another delighted fan. “I’m sure it can’t be easy for her given the recent events, but she always does a fantastic job because she’s a top-notch professional.”", "label": "No"}
{"text": "Sponsor a Wreath\nWe are pleased to announce that we have received enough sponsorships to place a wreath on every headstone at the North Dakota Veterans Cemetery in 2020! Thank you for your continued support of Wreaths Across America. Please see the WAA Event Information page for instructions on how wreath placement will take place this year.\nTo Sponsor a Wreath\nWe are no longer accepting sponsorships for 2020. If you are not already on our mailing list but would like to be added for 2021 please send your name and mailing address to firstname.lastname@example.org.", "label": "No"}
{"text": "A superb lightweight, cafe-style bistro set available to buy in a range of funky colours. The Royalcraft Cafe Espresso Folding Mesh Bistro Set has a modern mesh design and is made from powder-coated steel for strength and durability. Resistant to rust and corrosion, the 60cm (24\") round table and two chairs can be used all year round. Alternatively they all fold up for easy\nWhile away long summer evenings in comfort with the Wentworth 4-piece lounging set, featuring a classic wicker finish and timeless design. A coffee table topped with tempered glass is ideal for drinks or casual dining, while deeply cushioned seating ensures complete comfort. Thanks to an aluminium framework construction and hand-woven synthetic weave, this set offers style, comfort, strength and\nThis cream powder coated metal bistro set will look great on your balcony, patio, or in any sized garden. The table and chairs arrive fully assembled, and fold flat for easy storage and movement around your garden. We recommend moving the set into dry storage during periods of very bad weather. Dimensions: Table - H 70cm, D 60cm; Chair - H 81cm, D 46cm, W 42cm.\nEverything Castelli does is somehow designed to make you faster. Think of this Castelli Espresso 4 Softshell Jacket as your go-fast-in-July jacket. They didnt make it aero, so its not going to help you wind the club training rides in January. What Castelli did is include every creature comfort to help you get in as much training as you can stand over the winter. Its cut a little looser than their\nAdd a stylish touch to your home decor with this lovely black chair. A padded seat and back bring comfort and class to your indoor space. The chair can be used for dining or gaming Fashionable and functional, the Soho Bistro chair is the perfect transitional chair for your home decor Set includes: 2 chairs Materials: Wood, foam and fabric Finish: Deep espresso Upholstery color: Gray\nClassic wayfarer styling and refined aesthetics of the Canby mixes timeless style with the luxuriousness of exotic hardwoods for a look that is unforgettable. ; Premium-grade lumber frames are crafted using a 5-ply manufacturing technique. ; Custom real wood inlays with hand-finished veneer plates are guaranteed to be 100% unique. ; CR-39 lenses offers protection and superior coating for just the\nThe Savanna Espresso Cup and Saucer Gift Box by brand leaders Harlequin and Churchill. The set features four fine bone china espresso cups and saucers; the cups showcase a stunning Elephant print and the china saucer are detailed with a gooseberry green rim. The design has been adapted from best-selling designs in Harlequins portfolio and will make a beautiful addition to your collection.\nSome studies have shown that feeding your pet smaller meals over the course of the day can prevent pet obesity and lead to better health. Unfortunately, most working people cant get home to feed the cat at lunchtime, and many will forget to put out the dogs breakfast in their rush to get out the door in the morning! Make sure your pet is fed regular amounts on a steady feeding schedule with the\nAspen Pet Le Bistro Programmable Feeder is a convenient way to control your pets eating portions. The programmable system automatically dispenses pre-set portions of pet food, making feedings precise and easy. Programming the Electronic Le Bistro is as easy as setting an alarm clock. A large screen displays the current time, meals programmed, meal size and meals served. The Electronic Portion", "label": "No"}
{"text": "Top 10 world's highest-paid athletes\nUpdated: 2014-05-02 09:37\nSince 1990 Forbes has been tracking the earnings of athletes. Its 2013 World's Highest-paid Athletes list only included athletes active during the last 12-months and ended in June 2013.\nThe earnings figures used for the list include all salaries and bonuses paid out between June 1, 2012 and June 1, 2013.\nHere are the world's top 10 highest paid athletes:\nTotal: $41.3 million\nBarcelona's Lionel Messi kicks a fault before scoring a goal against Athletic Bilbao during their La Liga soccer match at Camp Nou stadium in Barcelona April 20, 2014. [Photo/Agencies]\n|Top 10 amazing night views in Beijing||Top 10 riskiest cities in the world||Top 10 Chinese cities to sail on yachts|", "label": "No"}
{"text": "Atmospheric photochemistry, Sulfur dioxide, Air pollution, Monitoring, Assessment\nThe level of sulfur(IV) oxide (SO2) in the tropospheric environment of Ilorin is presented using three urban classes and a control site from 2003-2006 wet and dry seasons. The mean concentrations over the years during wet and dry seasons were 1.29 ± 0.17 and 7.17 ± 0.87 (ppb), respectively. The wet season concentration was 15.25% lower than the dry season due to rain attenuation. The mean values at the control site for two seasons were one order of magnitude lower than those in the urban sites. The overall average concentration over Ilorin city was 4.23 ± 0.52 ppb. The value is comparable with other cities of the world and is within the limit of the United State Environmental Protection Agency (USEPA) Guidelines for Air Quality Standards. SO2 levels were found to varied significantly with vehicular intensity, other anthropogenic activities also decreased drastically during wet season. There was a significant difference (p = 0.05) between SO2 concentration with high and low traffic flow count; however, there was no difference (p = 0.05) between high traffic/medium population and medium traffic/high population density areas. The regression analysis indicated a correlation between SO2 and the hourly traffic volume in almost all the sites.", "label": "No"}
{"text": "As you already know, for the allowance of pharmaceutical patents, the Brazilian IP Law currently requires the prior consent from ANVISA (Brazilian Health Surveillance Agency – equivalent to American FDA) along with the usual examination from the BRPTO. It has been a while that both federal authorities dispute for the role of examining patents, which led to a double tier examination procedure.\nThe current flow established by Ordinance 1065 of May 25, 2012 developed by a Working Group formed by several Brazilian Ministries states that a pharmaceutical application should be sent to ANVISA for prior consent before being evaluated by BRPTO and, in case ANVISA denies the prior consent, that this application should be returned to the BRPTO in order to be shelved.\nAlthough the BRPTO and most of the Pharmaceutical companies always claimed that ANVISA's role is just evaluating what is contrary/unsafe to health, ANVISA has been evaluating patentability requirements for several years without clear guidelines and usually with a point of view much more related to political reasons than to technical or safety reasons.\nOn January 13, 2016, the BRPTO filed a petition in a Lawsuit that Abbvie INC filed against ANVISA (in which Abbvie questions ANVISA's role to analyze patentability requirements). Although the relationship between the BRPTO and ANVISA has been troubled since ANVISA started the double tier examination, this petition seems to be the clearest and strongest assertion ever made by the BRPTO against ANVISA. In such petition, the BRPTO really stands up to ANVISA's patentability analysis. The most relevant BRPTO's assertions, in our view, were:\n- that the BRPTO feels discredited by ANVISA's patentability analysis.\n- that there are no legal basis assigning to ANVISA the responsibility of analyzing the patentability requirements.\n- that ANVISA itself issued a Resolution assigning such responsibility to the own Agency when there is an IP Law that states that such responsibility is of the BRPTO, thus contravening the Principle of Legality.\n- that in case the BRPTO is obliged to publish the definitive shelving of a patent application in consequence of an ANVISA's decision of denying the prior consent, such procedure would not allow the submission of an appeal (since the BRPTO would not be entitled to review ANVISA's Technical Report) and, thus, this would contravene Brazilian IP Law.\nNow, both Abbvie and ANVISA will have a chance to file replies about such BRPTO's petition. We will keep you posted!\nIn case you have any doubt about this or any other pharma topic in Latin America, Spain or Portugal, please contact Ms. Luisa Rezende Castro (firstname.lastname@example.org).\nOriginally published March 15, 2016\nRio de Janeiro\nAv. Marechal Câmara, 160, 12º andar (Ed. Le Bourget), RJ 20020-080\nTel: +(55-21) 3223-9500\nThe content of this article is intended to provide a general guide to the subject matter. Specialist advice should be sought about your specific circumstances.", "label": "No"}
{"text": "What was the mileage rate for 2015?\nMore In Tax Pros\n|Period||Rates in cents per mile|\nWhat is the current rate for mileage reimbursement in Wisconsin?\n56 cents per mile\n56 cents per mile driven for business use, down 1.5 cents from the 2020 rate, 16 cents per mile driven for medical or moving purposes for qualified active-duty military members, down 1 cent from the rate for 2020, and.\nHow do you calculate gas mileage reimbursement?\nUsing a mileage rate The standard mileage rate is 56 cents per mile. To find your reimbursement, you multiply the number of miles by the rate: [miles] * [rate], or 175 miles * $0.56 = $98. B: You drive the company’s vehicle for business, and you pay the costs of operating it (gas, oil, maintenance, etc.).\nHow much do you get reimbursed for gas mileage?\n57.5 cents per mile driven for business purposes. 17 cents per mile driven for medical or moving purposes (20 cents per mile in 2019)\nCan a company pay less than the IRS mileage rate?\nEmployers don’t have to pay the IRS recommended rate… The standard mileage rate in 2020 for the use of a personal vehicle for business purposes is 57.5 cents per mile driven. That’s down 0.5 cents from 58 cents per mile in 2019. Some employers choose to reimburse at less than the IRS rate.\nIs there a standard reimbursement rate for employee mileage?\nThere is no standard reimbursement rate, as companies can set their own rate. Some companies will even offer various ways to “pay for” employee mileage. Options can include providing work cars or offering a gas allowance. This can also include reimbursement for company mileage.\nWhat’s the difference between IRS and GSA mileage reimbursement?\nThe IRS uses slightly different mileage reimbursement rates than the GSA but they are very close. As you can see below, the IRS breaks down how much you can deduct based on the purpose of your travel. These rates apply regardless of whether you drive a car, truck, or motorcycle.\nHow much does a standard mileage rate cost?\nStandard Mileage Rates Period Rates in cents per mile Rates in cents per mile Source 2016 54 19 IR-2015-137 2015 57.5 23 IR-2014-114 2014 56 23.5 IR-2013-95 2013 56.5 24 IR-2012-95\nHow many miles can I reimburse for a personally owned car?\nIn 2016, if driving a personally owned automobile for business travel and your destination is 100 miles from your home and you drive 50 miles in-and-around for approved business purposes at your destination, your mileage reimbursement would be: 100 miles one way x 2 = 200 miles round trip. 200 miles + 50 miles in-and-around = 250 miles.", "label": "No"}
{"text": "- Why College Athletes Shouldn’t Be Paid Opinion. …\n- #1 Bind to Contracts. …\n- #2 Not Fair to Other Students. …\n- #3 Athletes Will Neglect Studying. …\n- #4 Athletes Get More Chances for Scholarships. …\n- #5 Colleges Aren’t Sports Establishments. …\n- #6 It Will Raise the College Fees.\nWhy should not college athletes be paid?\nIf a university starts paying student-athletes, it could negatively affect other sports programs. There would not be enough funds to pay every single student-athlete equally and to be able to keep every single sport. The smaller sports that do not generate enough revenue to sustain the program would definitely get cut.\nWhat are the disadvantages of paying college athletes?\n- Student-athletes already receive a comprehensive payment. …\n- College athletes can gain publicity through television contracts and other forms of exposure. …\n- Only a handful of sports actually make a profit for a school.\nWhy is making college free a bad idea?\nIf higher education at public schools becomes free, it might appear to devalue a college degree. It might also lead to students cutting more classes or not trying because they don’t have to “get their money’s worth” when they aren’t paying for anything.\nWhy do college athletes get paid?\nUnder the NCAA rule change, college athletes get paid from their social media accounts, broker endorsement deals, autograph signings and other financial opportunities, and use an agent or representatives to do so.\nShould athletes be paid pros and cons?\n- Pro: College athletes put their bodies on the line each game they play.\n- Pro: Student-athletes generate serious revenue.\n- Pro: Paying college athletes would help to begin creating a sense of financial awareness.\n- Con: Many student-athletes already receive scholarships and other benefits.\nShould college be free pros and cons?\n|Free tuition education might lower the wage gap||Students might not value the education anymore|\n|Lower unemployment rates||Declining quality of college education|\n|Pressure on the students can decrease||Several students may not be suitable for the college|\nWhat are the disadvantages of free college?\n- It requires someone to pay for it. …\n- It might encourage financial irresponsibility. …\n- It could devalue the worth of a diploma. …\n- It would cause more people to go to college. …\n- It might reduce state programs in other essential areas.\nWhy should we pay for college?\nStudents Should Pay for College Because They Benefit the Most. Many people feel that even if there are societal benefits to a better educated population, the people that benefit the most are those who get the degree. Therefore, they should pay.\nShould education be free or not?\nAnswer: Free education guarantees that the overview of the life of all children will be the same. Candidates will experience increased employment: Free education means that most students will have access to education and increase their chances of getting employment.\nWhen did paying college athletes become an issue?\nLet’s go back to 2019, when California passed a law called the “Fair Pay to Play” act.\nWhat does the NCAA think about paying college athletes?\nWASHINGTON — The Supreme Court unanimously ruled on Monday that the N.C.A.A. could not bar relatively modest payments to student-athletes, a decision that underscored the growing challenges to a college sports system that generates huge sums for schools but provides little or no compensation to the players.\nWhy should athletes get paid so much?\nSo athletes in popular sports make a lot more money than important people such as teachers, police officers and firefighters. … These businesses pay the money because they know millions of fans will watch the games. TV networks then sell ads for cars, pizza and lots of other stuff that they show during the games.\nCan colleges afford to pay student athletes?\nUnder current NCAA regulations, compensation for student athletes is limited to scholarships for their education. … Although the law allows student athletes to profit from third-party deals, it does not require, or even allow, schools to pay student athletes for their work beyond the scholarships they already receive.\nWhy should college be free in the United States?\nFree college tuition programs have proved effective in helping mitigate the system’s current inequities by increasing college enrollment, lowering dependence on student loan debt and improving completion rates, especially among students of color and lower-income students who are often the first in their family to …\nWould free college help the economy?\nFree College Is Not Directly Linked to Economic Growth\nSince the provision of free college could affect the quality of education, free access for all to postsecondary education might not be able to provide the competencies and skills needed to produce a strong workforce.\nWhy should everyone free education?\nThis lifestyle requires people to have freedom to broadcast their talents, skill and testing new ideas and this would lead to happier people. With more happier people this would lead to a prosperous population. Another reason why a free education is beneficial is that the government is wasting resources.\nWhy professional athletes are not overpaid?\nFans pay to watch them perform because they really enjoy seeing them. Like other entertainers, such as actors and singers, athletes are paid large amounts for their performances. Professional athletes are not overpaid for the amount of physical and mental stress they go through to do their job.\nWhy is college so expensive?\nThere are a lot of reasons — growing demand, rising financial aid, lower state funding, the exploding cost of administrators, bloated student amenities packages. The most expensive colleges — Columbia, Vassar, Duke — will run you well over $50K a year just for tuition.\nHow would free college widen the workforce?\nIf more people could attend college for free, then the workforce will expand. The workforce will also be more agile. In the case of an economic downturn when one industry falters, another generally rises to replace it. Then, workers need to be retrained and taught skills for the job.\nDo athletes get paid too much debate?\nNo: “Athletes are paid millions of dollars to play a game” is a common argument people make for criticizing the annual salary of professional athletes. However, it is completely justified. Lebron James of the National Basketball Association (NBA) takes home 30.96 million dollars a season.\nWhy are athletes paid more than doctors?\nBecause people pay good money to watch them play. Tens of thousands of people pay as much as $100 per game and sometimes more to watch these athletes play. This generates a ot of revenue and profit for the team owners. The players who produce these big dollars can command high salaries.\nWhat are some arguments in favor of paying college athletes?\n- Argument 1: The Talent Should Receive Some of the Profits.\n- Argument 2: College Athletes Don’t Have Time to Work Other Jobs.\n- Argument 1: College Athletes Already Get Paid.\n- Argument 2: Paying College Athletes Would Side-Step the Real Problem.\nWhat happens if a college athlete accepts money?\nThe NCAA even enforces rules on how many hours an athlete can work for a company each week. If a player accepts money in any form, even if they do not know they are breaking rules and have no intentions of hiding it from the NCAA, an athlete can be dismissed from the school.\nHow much money would college athletes get paid?\nThey don’t generate much revenue for schools, so Borghesi estimates they would each earn about $21,000 a year. The next 45% of recruits are three-star players – athletes who have a strong chance to start during their career. Borghesi estimates these players would earn about $29,000 a year.\nWhat is the controversy with the NCAA and student-athletes over?\nThe Supreme Court ruled unanimously Monday against the NCAA in a dispute over what compensation schools can offer students who play for their sports teams, saying the college athletic association is not immune from antitrust rules—but the court did not strike down rules that stop athletes from getting paid for their …", "label": "No"}
{"text": "In Ray Bradbury’s A Sound of Thunder, Eckels hires Time Safari, Inc., to take him back to the Late Cretaceous to hunt a Tyrannosaurus Rex. When he faces his quarry, he loses all bravado and panics. He leaves the path, steps on a butterfly, and alters the present-day. Words are spelled differently. The other candidate won the election.\nMcCoy steps through the Guardian of Forever and stops Edith Keeler from being hit by a car. Keeler delays the US’s entry into World War II, Germany wins, and the Federation ceases to exist mid-sentence.\nMarty McFly saves his father from getting hit by a car (different car) and almost erases himself from existence. Barry Allen saves his mother from getting killed when he was a child and… you get the picture.\nIt’s a trope of science fiction. Time travelers are always concerned about changing the present by making some small change in the past, but we never think that we can seriously change the future by making some small change today.\nPhoto courtesy of © Adobe Stock / eugenesergeev\nWhen the Apple Watch was first introduced, there was a lot of optimism about the new ways it would enable us to be productive. One of the common questions was whether you would be able to wear it in the shower to talk to Siri.\nI understand the question. We can come up with some great ideas in the shower. This might be the only time we have to step back from a problem and think about it, and Siri gives us a way to capture those key insights.\nIf you really can’t go 10 minutes without talking to Siri, then yes. Yes, you can wear your Apple Watch (series 2 or later) in the shower. With some precautions, you won’t even break it.\nPhoto courtesy of © Adobe Stock / Lucian Milasan\nYou’re probably doing better in some areas of your life than in others. How do you know where you should set goals to improve? And what’s the one limiting belief that’s holding you back more than anything?\nMentioned in the video: Roles Worksheet, Michael Hyatt’s LifeScore Assessment\nThere are three things you need in order to do anything, whether it’s productive work or having fun: time, energy, and money. If you have all the time, energy, and money in the world, you’re unstoppable. You can do anything you want.\nIf you’re reading this, you’re probably lacking at least one of those three. (I’m writing it, and I know I am.)\nWhich one we’re lacking varies from day to day and sometimes over the course of a day. Thinking in broad strokes, each one of them takes a turn being generally scarce as we go through life. Thinking in really broad strokes, they line up with the second, third, and fourth vicennia of life.\nThis is the book Dr. Stephen R. Covey is best known for. It’s one of the best books on self-leadership ever. You should have a copy in your library. (Amazon agrees—it’s included with Kindle Unlimited.)\nObviously, the seven habits are the meat and potatoes of the book. The first three habits are personal; they cover how you should handle yourself, and they’re largely focused on planning and being intentional with your life. The next three habits are interpersonal—how you interact with other people. The seventh habit is a keystone habit that will make sure you never stop growing.\nThe habits are:\n- Be proactive. You are responsible for what happens in your life. You have the power and responsibility to make choices and steer your ship instead of blaming the current for where you end up.\n- Begin with the end in mind. All things are created twice—first mentally, then physically. You can imagine a better outcome than what you currently see and be proactive to make that outcome happen.\n- Put first things first. If you want to make that better outcome happen, you have to identify your priorities, place the important above the merely urgent, and let go of things that just don’t matter.\n- Think win-win. See life as a collaboration, not a competition. The best way to get what you want is to help other people get what they want. Any other arrangement is unsustainable.\n- Seek first to understand, then to be understood. Listen. Understand the other person’s position so well you can articulate it better than they can. Then you can build a framework for open and honest communication that will lead and influence through mutual respect instead of whoever can shout loudest.\n- Synergize. It’s a buzzword that’s gotten a bad rap, but it’s powerful. The whole really can (and should) be greater than the sum of its parts. It’s okay to be different, because that’s what lets synergy happen.\n- Sharpen the saw. There are four key aspects of your life: physical, mental, social/emotional, and spiritual. You have to take care of yourself in all areas in order to maintain and grow your effectiveness.\nSome of the most applicable tools I got from 7 Habits are some of the supporting concepts that Covey uses to unpack the Habits. Things like the Eisenhower Productivity Matrix, the abundance mentality, the importance of a personal mission statement, the power of unconditional love, the impact our self-talk can have, the circles of influence and concern, and visualizing the speakers at your own funeral (or 80th birthday party, if you prefer).\nYou can always read a book, put it on the shelf, and not be any different for having read it. If you will study 7 Habits and re-read the book—however many times it takes for things to start sinking in—it will transform your life. It will change the way you approach problems. It will change the way you think. It will permeate everything else you do to improve yourself, and you will improve faster.\nEnergy is the capacity to do work. It’s stored in electrical, chemical, thermal, gravitational, nuclear, or mechanical form and transformed by machines into another form. It’s never a perfect transformation. Some of the potential is lost to inefficiency—friction, heat, vibration, noise, wear.\nIn a Freshman Physics class, you often model things using a spherical cow of uniform density in a vacuum (they’re also frictionless, inert, of a neutral charge…). You are taught to ignore the inefficiencies so you can focus on the larger principles.\nWe often make the same simplifications when we plan. That’s not a bad thing, but it does mean that things aren’t going to go as planned. Sound familiar? It happens because your planning model is off.\nThe simplest way to get more done is to remove the inefficiencies. Let more of that potential be transformed into useful work.\nPhoto courtesy of © Adobe Stock / Daxiao Productions\nAnything you do on a regular basis (which you can’t eliminate or delegate) can and should be automated. If you have to do it, you may as well make it as easy as possible. (You’ll also waste less time procrastinating and actually do it.)\nIt’s not even the big things that need automated. Sometimes, it’s the small things—the deaths by a thousand cuts—that we appreciate more.\nOn macOS, you have AppleScript, a powerful language to create custom workflows and tie apps together. There’s also Automator, an app that lets you create workflows by combining actions with drag-and-drop simplicity—no programming required!\nOn iOS, there’s the aptly-named Workflow. Like Automator, you create a workflow by dragging together a series of actions. Each action performs a task and passes the result on to the next step.\nTo be honest, I didn’t really get what Workflow was capable of when I first heard about it. I knew how Automator (and AppleScript) worked, and I knew that wasn’t possible on an iPhone. It only made sense after I downloaded it and started using it.\nSo let’s create one of the workflows that I use the most: telling my wife I’m on my way home.\nPhoto courtesy of © Adobe Stock / nd3000. I’m sure the photo wasn’t taken while the car was in motion.", "label": "No"}
{"text": "Prices for NBA 2K22 Turkey are as follows: The standard package will cost 429 TL and Nba 2k22 Mt the 75th anniversary package costs 709 TL. Lakers Update: Kareem Abdul-Jabbar Joins Luka Doncic, Kevin Durant, Dirk Nowitzki and Candace Parker As Cover Athletes for NBA 2K22. The NBA 2K22 cover athletes have been announced. Los Angeles Lakers legend Karem Abdul-Jabbar joins Luka Doncic, Kevin Durant, Dirk Nowitzki, and Candace Parker to celebrate the 75th anniversary of the NBA's game.\nIn the case of the regular version of the game, Dallas Mavericks star Luka Doncic will be the cover model this year. Former Los Angeles Sparks and current Chicago Sky star Candace Parker will also become the first female athlete with covers in recognition of the WNBA's 25th anniversary. NBA 2K22 is set to be released in the world on Sept. 10, although pre-order sales are taking place now:\nNBA 2k has proven to be the leader in innovation in the field of games with sports in recent times, so it'll be interesting to see what ideas they come up with for this new version. Recent additions such as The Neighborhood and WNBA players have helped broaden the game's options, allowing players to choose different options for playing that are not just a regular NBA game.\nAbdul-Jabbar presents Carmelo Anthony the first-ever social injustice award. Abdul-Jabbar who is not only one of the top basketball players of all time and also one of the most notable social justice champions, just had the NBA's first-ever social justice award named for him.\nPortland Trail Blazers veteran Carmelo Anthony was the recipient of the award in 2021 and was given the award by Abdul-Jabbar himself. Kevin Durant leaves his ex-Warriors teammate from his dream team to join two Lakers instead. The present Team USA team is far from the great team of players who made up the 1992 United States men’s Olympics team. This squad was led by Magic Johnson, Larry Bird and buy mt nba 2k22 Michael Jordan. The 2021 Americans aren't too shabby however.", "label": "No"}
{"text": "Introducing Quadrant Court!\nToday I am introducing a new paper-pieced quilt pattern - Quadrant Court! This fun and fast pattern uses three fabrics to create a visually intriguing quilt. Each block contains three sewing lines, so this quilt flies together! The pattern includes full size foundations, three pattern sizes and complete paper-piecing instructions. This is a great pattern for paper-piecing beginners and experts alike!\nFor the cover quilt, we chose a black and a white print for the X's, each with a subtle tone-on-tone print, and a solid teal for the background. Throw in a black and white diagonal stripe for the binding, and voilà! All of these fabrics from Robert Kaufman turned into a beautiful quilt!\nOur talented friend, Juli Kieny quilted this Quadrant Court. She quilted serpentining lines in the background, swirls in the white and two straight lines in each black wedge. I love how the contrast of the quilting designs in the black and the white fabrics plays with the design.\nI had lugged my quilt ladder (aka an Ikea towel rack) down the street a block and to a worn down garage. I leaned the ladder up and draped the quilt on the ladder. I love this background! It reminds me of those photography backdrops from the 90s we took family photos in front of!\nQuick Quilt Stats:\n- Made by: Kristy Wolf\n- Quilted by: Juli Kieny\n- Quilting: Serpentining lines, swirls and straight lines.\n- Pattern: Quadrant Court\n- Fabric: White-on-white dot and black circle print from Remix by Ann Kelle, and Kona Cotton Breakers, all from Robert Kaufman Fabrics.\n- Finished Size: Grande 60\" x 72\"\n- Techniques: Paper-piecing\nAnd knowing us, we can't just make one version of any of our patterns, we had our good friend Juli sew up a Quadrant Court quilt made up in Art Gallery Fabrics.\nI had a blast shooting this quilt! I was driving around Boulder, CO scouting backdrops for our Paradox Point quilt cover and came across this mural. I knew it was too busy for a cover photo, but couldn't resist draping this version of Quadrant Court in front of it for a few photos! The mural was designed so the window is being picked up by the figure, so I placed the quilt in front of the window and I love how it looks!\nIt is always fun to play with different fabrics in designs. I love the contrast of the ditsy floral print with this very geometric design. Juli did an amazing job, as always! She quilted serpentining lines across both the magenta and floral print and a flower that filled the background diamond.\nQuick Quilt Stats:\nThe Quadrant Court pattern is available in both PDF and paper form. If you make this or any other Sassafras Lane project, we would love to see it! Send us photos, post them to our Flickr group or use our #sassafraslane hashtag on Instagram! Next I will be sharing all 4 versions of our new BOM pattern, Paradox Point!", "label": "No"}
{"text": "Small business spotlight: Martino Flynn, an advertising and marketing agency\nIn the fast-paced, up-to-the-minute world of advertising and marketing, keeping up with trends is crucial.\nThat goes for the workplace as well as the product and process. For Martino Flynn, a Pittsford-based agency, that means having a work environment unlike the “typical.”\n“Technology and millennials are at the forefront of our business,” said Chris Flynn, one of the firm’s three partners. “We’re giving everyone the freedom to be creative. Millennials are smart people who work differently. We have more open spaces — it’s more like a café than a cube world. They’re working no matter where they’re seated. They’re doing work at home.”\nAdapting to those kinds of changes may be one reason why Martino Flynn again was named to the Democrat and Chronicle’s “Top Workplaces” list. The firm was founded in 1997 but the roots go back to the 1960s, the Mad Men era well before the internet turned the world upside down.\nJerry Flynn, a well-known local toastmaster, started The Flynn Agency in 1967. It was an advertising/marketing firm that dealt primarily with sports clients and retail clients.\nMORE SMALL BUSINESS SPOTLIGHT FEATURES: Upstate Granite and Marble, Butler/Till, a media communications agency, Milt & Ron’s Transmission, PSquared Digital maximizes digital maze\nRay Martino had been, among other jobs, a speechwriter for a local state senator before he started Martino & Associates, a public relations agency. Martino Flynn came about when the two companies merged. Now, the work description is “integrated marketing communications firm.”\nThat’s because of all the technology now involved in connecting product with potential customer. It’s not just advertising, it’s interactive.\n“It went from monologue to dialogue,” said Kevin Flynn, Chris’ brother. “The consumer can talk back to us. It changed the way the brand has communicated with the customer.”\nKevin and Chris bought out their father in the mid-1980s and extended the business to other types of clients. Jerry Flynn, who emceed thousands of dinners and was a former president of the Rochester Press-Radio Club, died in 2004.\nThe brothers Flynn talked about the breakthrough when they first added video-editing capabilities, which they said was “unheard of” for an ad agency at the time. They talked about newer platforms, like Facebook Live, and others like Snapchat.\n“In the past, you didn’t have as much feedback,” Chris Flynn said of the advertising/marketing work and technology. “Now, it’s immediate. It’s changing daily, if not hourly.”\nMartino Flynn does a lot with digital media, social media and online media planning and buying. Research and “insight” components have been added to the work. But along with all the modern technological tools, “telling meaningful and emotional stories, that’s still very important,” Kevin Flynn said. “Content is king,” his brother adds.\nSo, too, is creating and fostering a good workplace to attract and retain talented workers.\n“Culture trumps everything,” Kevin Flynn said. “It’s not just about Taco Tuesdays, but about providing an environment where people can flourish. We help people with career growth.”\nMartino has announced his retirement and is staying on until mid-year as a consultant. Kevin Flynn laughed and said Martino still will be around, maybe not “officially,” but never really out of the picture because the three are close friends. The firm will continue to be known as Martino Flynn.\nAlan Morrell is a Rochester-based freelance writer\nLocation: 175 Sully’s Trail, Pittsford.\nExecutives: Kevin Flynn, Chris Flynn and Ray Martino are partners. The company has no designated “president” or “CEO.”", "label": "No"}
{"text": "The Final Logo:\n“The Leadership Development Group develops, coaches, and mentors leaders globally. We help leaders thrive, flourish, and change the world. ”\n“The creative output of Joel and The Graphics Lab never ceases to amaze and thrill me. I’ve used The Graphics Lab multiple times over the years, and designs are consistently on-time and delightful. I highly recommend Joel for your branding needs.”\nCan I design a logo for you?", "label": "No"}
{"text": "I read with great interest your article entitled “Sans Intervention, Taxes Will Spike Further, Report Finds” in your most recent edition. While we know Woodbridge to be an intentionally “bedroom” community with little commercial development, the figures presented in the article don’t bode well for our taxes in the future. We know we must continue to invest in education – many call Beecher and Amity the “crown jewel” of Woodbridge, so looking elsewhere for savings seems obvious. I think that leaves looking for savings in the cost of town government.\nAt the end of the article, First Selectman Beth Heller seems to provide some political double-speak. The Board of Selectmen recommended to the Board of Finance to seek a 3% cut across the town budget – but Beth voted against that recommendation – the only “no” vote! She then is quoted in an email communication written after the vote, saying the cuts should not be “restricted to 3%,” and adds the predictable line in an election year “to provide relief to our taxpayers.” A 3% cut isn’t a bad place to start, so why vote no? Continuing the spin on page 10 of the same edition, in the article “Town Budget Next Steps” Beth writes: “I worked closely with Town Finance Director Tony Genovese to identify ways to minimize the impact to taxpayers while ensuring we continue to provide necessary services to townspeople with next year’s budget.” So why wasn’t the “taxpayer relief” Beth wanted incorporated in the budget she proposed to the Board of Selectmen? Please don’t say you are for tightening our budget belt, then present a budget with none of it, and worse, vote against it!\nWhile many Woodbridge residents have traditionally shrugged off tax increases, the fact that mid-sized home values continue to slide, due in large part to our taxes, I hope this will act as a signal that our shrugging days are over. Our town leaders need to step up the effort to trim local government spending and produce tangible results.", "label": "No"}
{"text": "Before June 30th, 2018 PayPal is requiring all account users to update their browsers to remain compliant with new security standards. You will not be able to access your PayPal account after June 30th if your browser isn’t updated. Learn how to upgrade your browser.\nCan I reopen a closed dispute?Why is my payment on hold for a dispute, claim, or chargeback?When should I escalate a dispute to a claim?Can I appeal PayPal’s decision on my claim?How long does it take to investigate my claim?How do I check the status of my dispute or claim?How do I escalate a dispute to a claim?How do I provide additional information or evidence to help resolve a dispute or claim?What if I can't resolve my dispute?How long will it take to restore my account access?\nYou were logged out to help protect your account.", "label": "No"}
{"text": "Are you thinking about refurbishing your floors? There are many materials available, but limestone is one that comes with many great advantages. Limestone flooring is elegant, durable, and extremely versatile and is even considered more hygienic! These are just some of the many reasons why you should choose limestone flooring.\nWhat Are The Advantages of Limestone Flooring?\nBeautiful floors should last a lifetime. If you are looking for a flooring tile that will last and maintain its elegance, limestone flooring is the material for you. There are many advantages to limestone flooring, as shown below:\nBeautiful, natural look. Limestone has a naturally dull exterior to give your home that rustic -country’ look. Variety. Limestone flooring is available in a range of shades and textures, so you are sure to find something that fulfils your dream. The warmth, earthy tones of limestone will add ambience to your living space. Low maintenance. Due to its durability, this stone does not require a lot of maintenance when sealed correctly. All you need to do is mop with a mild detergent to keep it clean. A worthwhile investment. As limestone flooring is durable and long-lasting, it is a worthwhile investment. It will keep its elegance for many years to come; it is renowned for -ageing’ well and can last decades. Hygienic and hypoallergenic. Its reported Germs cannot settle in limestone flooring, therefore there is no dust build-up. It is also a hypoallergenic material so it is perfect for those who suffer with asthma or any other allergies. Versatile. Limestone is not a material that is confined to flooring, as it can be used a wall tiles also. Limestone flooring is suitable for outdoor spaces and is popular in many outdoor landscaping projects.\nIt is clear that limestone flooring is the best choice if you are looking for something that is versatile, durable and elegant.\nLimestone Flooring For Domestic and Commercial Applications\nLimestone flooring is suitable for domestic and commercial applications. Add a touch of class and elegance to your home, entrance hall, or use limestone for your wall tiles in your bathroom. The range of shades and textures available ensures that you will find perfect colour scheme for your interior design.\nCeramica & Stone are the leading retailer of high quality limestone flooring. With over four decades of experience in natural stone solutions, they will find the right material and design for you. Their exclusive installation team are dedicated to ensuring the highest quality throughout your refurbishment project.\nTo find out more about the range of limestone flooring Ceramica & Stone have to offer, call 01491 412455. Alternatively, you can email them at .", "label": "No"}
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{"text": "SOURCE TOI : 29-04-2012 >>MUGGING YOUR WAY TO SELF REALIZATION !!\nMugging injury turns man into math genius\nA brutal beating outside a club left college dropout Jason Padgett with brain damage. But the furniture store worker discovered he could draw diagrams, turning mathematical formulae into stunning works of art\nWHAT HAPPNED 10 YEARS AGO ON A LOVELY NIGHT??\nA college dropout has turned a unique maths genius after his brain was damaged in a brutal attack by muggers.\nJason Padgett, 41, was left concussed after he was ambushed outside a club. But now, wherever he looks, he sees mathematical formulas and turns them into stunning, intricate diagrams he can draw by hand, Daily Mail reported.\nSAGA OF THE ONLY MAN ON EARTH WHO HAS THIS GIFT!!\nThe remarkable story began 10 years ago when Padgett was only interested in two things: working out and partying. One night while leaving a club he was attacked by muggers who brutally kicked his head repeatedly.\nPadgett is the only person in the world known to have the skill and experts believe the damage to his brain left him with a \"remarkable gift\" for figures, much like the brilliant mathematician John Nash.\nPadgett, who works at a furniture store in Washington, told ABC News: \"I'm obsessed with numbers, geometry specifically. I literally dream about it. There's not a moment that I can't see it, and it just doesn't turn off.\"\nEFFECT OF BEING HIT ON THE HEAD >> READ THIS IS IMPORTANT !!\nDoctors said he had a concussion, but within a day or two, Padgett began noticing something remarkable - while earlier he could not draw, he was now obsessed with producing intricate diagrams, even though he had no idea what they were. \"I see bits and pieces of the Pythagorean theorem everywhere,\" he said. \"Every single little curve, every single spiral, every tree is part of that equation.\"\nPADGETT DRAWS FRACTAL SHAPES WHICH IS A WOW !!!\nPadgett draws diagrams called fractals. He can produce a visual representation of the formula Pi, the infinite number which begins with 3.14.\nHis drawings are up for sale (L-R): ‘Snowflake shape comes from frequency and mass’, ‘Nuclear Fusion’ and ‘Quantum Hand through my eyes\nWHAT ARE FRACTAL SHAPES?\nHe said: \"A fractal is a shape that when you take the shape apart into pieces, the pieces are the same or similar to the whole. So say I had 1,000 pictures of you that were little and I put all those little pictures of you in the right spot to make the exact same picture of you, but bigger.\"\nMuch like Nash, who was played by Russell Crowe in the 2001 film, A Beautiful Mind, researchers believe Padgett has a remarkable gift.\nWHAT HAPPENED IN PADGETT’S BRAIN AFTER MUGGING?\nTo understand his brain, neuroscientist Berit Brogaard flew Padgett to Finland. A scan showed damage that was forcing his brain to overcompensate in areas that most people don't have access to.\nProf Brogaard said Padgett is now an acquired savant, meaning brilliant in a specific area. \"Savant syndrome is the development of a particular skill to an extreme degree that makes a person superhuman,\" she said.\nPadgett said his goal was to get out of the furniture store and hopefully teach others that maths is as beautiful and natural as the world around us. PTI AGENCIES\nIMPACT ON SPIRITUALISTS :\n1. We can consider activating those portions of the brain which get activated during deep mediation and self realization by either asking muggers or some one known to us to hit us on the head.\n2. Apart from suddenly becoming proficient in Maths, Sanskrit, and other languages we will also suddenly become fluent in the languages spoken by GOD.\n3. DOWNSIDE : There is possibility that the wrong areas may be hit by the mugger resulting in un-desirable consequences Hence the advice of a Neuro-Physician or Surgeon who is also advised by advanced Spiritualists who are aware of the correct areas of the brain that needs to be hit to get the right activations is considered essential.", "label": "No"}
{"text": "Welp, it was finally time to pull the plug. On running, that is. I made it to almost 32 weeks of pregnancy, but my pelvis, squashed bladder, and crowded torso could not justify waddling a few minutes at a time anymore. Walking it is, and shall be, for the near future. Part of me is sad about my running hiatus, these next 8ish weeks and recovery time after baby is born will be the longest I have gone without running in YEARS! It has become so ingrained in my days and routine and identity, that I feel a little lost. Now that I am not running… at all, my training logs are surely going to be more boring than they already are. For this reason, I am planning on recapping 2 weeks at a time for the rest of this pregnancy. As far as pregnancy milestones go, I no longer have a belly button. It has disappeared. Our nursery is coming together, as well. I have a baby shower coming up on the 28th. I guess this baby thing is really happening … and soon! Seven-ish weeks until baby Barberry makes her grand arrival, hopefully!\n10/15 – No activity done. This past weekend’s wedding festivities have worn me out!\n10/16 – My husband and I went to a show in downtown Indy. We walked around a little bit, but no continuous exercise truly occurred on this day.\n10/17 – After taking 2 days of rest, I had to do something on my day off of work! I opted to keep my workout inside today. I went to the Rec Center and did a 2 mile walk on the treadmill, and then 1 mile around indoor track. I can’t even walk for longer distances without having to stop for potty breaks at this time. I did some strength training moves after my walk. I continued to focus on some major body parts needed to provide strength and stability post-baby. I did some squats, lunges, deadlifts, rows, and clamshells. I have also been working on stretching my calves more. Those suckers are getting tight and giving me some cramps!\n10/18 – Today seemed to be the longest day ever at work. No rest and very few opportunities to sit down lead to one exhausted pregnant lady. Thankfully, my sweet hubby had dinner going when I got home! He’s been so helpful, I am so grateful!\n10/19 – This morning I did a 2 mile walk on our treadmill while watching The Office before going into work. We also had another baby appointment today after work. Baby is still looking and sounding good!\n10/20 – I did a 1 hour walk this morning. I walked 3.45 miles in that time. Something I have had to make adjustments for since I started walking my miles is to try and figure out what to wear when I am out on my walks! Walking doesn’t warm me up quite as well as running. I usually have my gear gauge figured out pretty well for running temperatures. I will keep working on this as temperatures get cooler. It may also mean more treadmill walks in the future. Tonight, I also went to another wedding for a friend. This pregnant lady still has a few moves 😉\n10/21 – We had a pretty busy Sunday, with a get together with friends from college. No workouts.\n10/22 – Resting again!\n10/23 – After work and dinner, I did a 2.5 mile walk on treadmill in our house while watching the Voice.\n10/24 – Ahhh … a day off. I am valuing my days off more than ever now! I went to a local park again and did a 3.5 mile walk around the paved trails. About 2.5 miles into the walk, I stopped in one of the empty shelter houses to do a few strength moves. I did some walking lunges, body weight squats, single leg squats, push ups on the back of a bench, and tricep dips with the bench. It was a beautiful, sunny morning and the leaves are finally starting to turn pretty fall colors!\n10/25 – Today was my dad’s birthday! We joined him for dinner after work and had a nice time with family.\n10/26 – I did a 2 mile walk on the treadmill before work. I’ve continued wearing my support belt during my walks. I find that it helps take some of the pressure off of my bladder. My husband had a few friends over this weekend, so while they were out at a haunted house, I got to watch Hallmark Channel Christmas movies. Feel free to judge me!\n10/27 – I did another 1 hour walk, walking 3.5 miles. It was another cool, sunny morning. I managed to walk the whole thing without a bathroom break!\n10/28 – No exercise today. We had a baby shower for our little girl. Let’s just say she is very spoiled already!\nI will continue to waddle on as long as I can. This weekend we have our 6th wedding anniversary. We will participating in the Monumental Half Marathon (my hubby) and the 5K (me … walking!) that morning. This year’s race will look much different than last year when we both ran the full Marathon. That’s the way it goes, I suppose. Have a great week, everyone!", "label": "No"}
{"text": "Los Angeles Clippers (9-8) vs Portland Trail Blazers (7-10) Staples Center 7:30 p.m. PST November 30, 2015 Fox Prime Ticket Last time they met? November 20, 2015 — A couple of weeks ago, the Clippers were attempting to bounce back after another heartbreaker at the hands of Golden State but the[...]\nBuzzer Reaction Minnesota Timberwolves 99 Final Recap | Box score 107 Los Angeles Clippers MVP: Blake Griffin has had some slow 4th quarters this month. That wasn’t a problem against the Timberwolves, as he scored 12 of his 26 points in the 4th, making 5-of-6 from the field, making a three, an[...]\nLet's Go Clippers, let's go! This 2019/2020 season is going be incredible and we're watching every step with you.\nThank you for 11+ years of ClipperBlog. We're taking an undetermined hiatus but this site and archives will remain up for as long as we feel like paying the server bills. Thanks to all of the contributors, readers & supporters. Follow our instagram for future updates.", "label": "No"}
{"text": "Wednesday Night Live, March 2\nFamily Dinner is back!\nDue to revisions in our COVID-19 protocols, we will once again offer tables in Community Hall for on-site dining on Wednesdays at 5 p.m. Bring your own food or, better yet, order Koinonia Cafe To Go. Drinks and dessert will be provided by the church.\nIn addition to a noon Ash Wednesday service, Wilshire will offer an Ash Wednesday service at 6 p.m. in McIver Chapel.\nChildren’s Ash Wednesday\nA special children’s Ash Wednesday service will be held at 6:40 p.m. in McIver Chapel. Kindergarteners through sixth graders are invited to start in Room 2225 at 6 p.m. for a short time of choir and preparation before moving to the Chapel at 6:40. Parents, please pick up your children from the Chapel at 7 p.m. Childcare for younger children will be available in the preschool area.\n■ March 9: Music, Missions and More for preschoolers and children, 6 p.m.\n■ March 9: Resident-Led Lenten Study begins in the Parlor.\n■ March 16: No activities (Spring Break).\nCoffee and Conversation today\n■ Coffee and Conversation with Senior Pastor George Mason will be held Sunday, Feb. 27, at 10 a.m. This informal time in George’s study (Room 2203) gives guests and new members a chance to ask questions about Wilshire.\n■ The monthly Wilshire Welcome Class helps guests and new members learn what Wilshire is all about. The class will meet Sunday, March 27, at 10 a.m. in the Prayer Room (1100B).\n■ Questions about these events? Contact Carolyn Murray at firstname.lastname@example.org.\nVolunteers needed for refugee support team\nWilshire will work through Refugee Services of Texas to support a family of 11 from Afghanistan as it settles in the area. We are looking to assemble a team of people who are willing to embrace this family for at least three months and help them through the process of adjusting to a new country. Anyone interested can come to a training session this Sunday, Feb. 27, at noon in Room 3301. A box lunch will be provided. Contact Associate Pastor Heather Mustain at email@example.com to learn more.\nPiano Affinity Group postponed\nThe meeting of Wilshire’s Piano Affinity Group scheduled for Sunday, Feb. 27, has been postponed to Sunday, March 27, at 4 p.m. in McIver Chapel. To learn more about the group, contact Max Tucker at 214-215-3766.\nCandidates sought for director of operations position\nWilshire is currently seeking a full-time director of operations to manage the church’s physical structure and information technology. The position is salaried, and benefits include health, vision and dental insurance, life insurance and retirement. Potential candidates can learn more and apply at wilshirebc.org/employment. The deadline to apply is Monday, Feb. 28.\nAdventurers Chicago trip\nThe Wilshire Adventurers will travel to Chicago, Grand Rapids and Mackinac Island on Sept. 1–8. The week-long trip led by Rob and Pam Banta will begin with three nights in downtown Chicago, a river cruise, a lake cruise, history and arts tours and great food. The group will then travel to Grand Rapids to see the Gerald Ford Presidential Museum and Meijer Gardens before heading to beautiful Mackinac Island for three nights. Find details at wilshirebc.org/registration or in a brochure available in the main office. Registration will be on a first-come, first-served basis, with only 50 seats available.\nAdventurers Movie Afternoon\nThe Wilshire Adventurers will enjoy an Afternoon at the Movies on Monday, March 14, at 1 p.m. in Community Hall. The featured movie is Going in Style (2017), and popcorn, shamrock cookies and drinks will be provided. Bring your own camping chair if you prefer lounging. Cost is $5 per person. There is no need to register. Adventurers events are open to those 60 and up.\nRacial equity town hall, March 7\nWilshire’s Community Hall will be the site for a citywide town hall on racial equity on Monday, March 7, at 7 p.m. The event, hosted by Dallas City Council Member Casey Thomas, will focus on redressing racial inequities in Dallas housing and community development using findings from the city’s recently-completed Racial Equity Audit. Council Members Paul Ridley, Paula Blackmon and Gay Donnell Willis will also attend. Casey Thomas was our guest in worship on Jan. 16, and his interview with George Mason can be found here.\nHealth screenings, March 17\nNew Year’s resolutions may be forgotten by now, but it’s still a good time to plan ahead for good health in 2022. Life Line Screening will be at Wilshire on Thursday, March 17, to offer five screenings: carotid artery; heart rhythm; abdominal aortic aneurysm; peripheral arterial disease (poor lower-body circulation); and osteoporosis. Flyers with more details are available in the main office. Make a reservation at http://llsa.social/HSC or call 1-888-653-6450. How often should one have this screening? If the findings are normal, every three to four years is sufficient. If there are indications of problems, more frequent screenings may be indicated. If you have questions, contact Parish Nurse Linda Garner at 214-452-3151 or firstname.lastname@example.org.\nChildren’s Ministry interns sought\nWilshire is offering two paid ($12/hr.) Children’s Ministry internships this summer. Internships will run May 23 to July 31 or May 31 to Aug. 7, and will entail 25 to 30 hours weekly plus a four-day overnight camp working with K – 6 students. Interns will work with church staff and volunteers on programs including Sunday School, Vacation Bible School, Preteen Camp and special events. Most hours will be weekday mornings and Sunday mornings. Hours are flexible except for camp dates. Candidates should have completed at least one but preferably two or more years of college and have experience working with children and a desire to explore the opportunity to serve in a ministry position. To learn more, contact Minister to Children Julie Girards at email@example.com.\nWomen of Wilshire book clubs\n■ The WOW! Tuesday Evening Book Club meets in the Parlor monthly at 6:30 p.m. On March 8, the group will discuss A Wrinkle in Time by Madeline L’Engle. Zoom available by request. Contact: Debby Burton (firstname.lastname@example.org).\n■ The WOW! Brown Bag Book Club meets one Thursday a month at noon in Room 1205-L.\nOn March 3, the group will discuss The Last Thing He Told Me by Laura Dave. Contact: Abbey Adcox (email@example.com).\nVolunteer for Friday Friends\nFriday Friends needs volunteers to engage one-on-one with individuals living with early-stage dementia at the group’s twice-monthly meetings. For more information, contact Marilyn Morgan at firstname.lastname@example.org or 214-662-9451.\nDate set for Spaghetti Lunch and Silent Auction\nThe annual Youth Choir Spaghetti Lunch and Silent Auction will be held Sunday, April 10, from 11 a.m. to 1 p.m. The event will be the main fundraiser for the Youth Choir’s summer mission tour to Denver. More details to come.\nPrint statements with Realm\nWith Realm, you can view, download or print your contribution statement at any time by following these instructions:\n- Sign in to your Realm account on a computer.\n- Choose Giving from the menu.\n- Click the (funnel) icon to filter the gifts that display or to change the date range.\n- Click the (printer) icon to generate the statement.\n- Click Print. A preview of your statement will display.\n- Click the printer icon to print or click Download for a PDF file.\nCBF General Assembly in Dallas\nRegistration is open for the Cooperative Baptist Fellowship’s 2022 General Assembly, which will be held in Dallas June 28–30. CBF is Wilshire’s primary global partner for missions and ministry, and General Assembly is CBF’s annual gathering for learning, worship, inspiration and fellowship. Sessions will be held at the Hyatt Regency downtown. Learn more and register at cbf.net/general-assembly.", "label": "No"}
{"text": "Single Parent Trucker Men - Trucker Dating - United States\nBrowse listings of Man members that have joined Trucker Lifestyle that are associated with Single Parent. Talking to other members who have similar interests is a pefect way to come up with ideas to do on a first date. Register for a 100% Free Account to Date Tonight!\nDon't count the days, make the days count\". As for me a single laid-back Colorado native who can clean up good and just knows how to turn on the charm. I'm an avid dog lover. NO CATS PLEASE! I do have alot of hobbies I really enjoy and in time will share when we meet.Interested just stop by and...\nlets start by shareing a smile or two a laugh an a hug lets keep on the positive side of life i know how to treat a lady imma ole fashioned well seasoned veteran that loves his country an the people in it loves meeting people an an ole fashioned woman that believes in gentlemen......\nDon't be shy to message, even though I'm not a paid member yet, just checking", "label": "No"}
{"text": "CCTV’s uses & how to get the most of it\nHow to use a CCTV system\nIn modern society, from the moment you leave your door in the morning till you return at night, you will be recorded on average 15-55 times per day. As technology becomes much more advanced we will see more uses of CCTV.\nCCTV is a fantastic piece of technology on a domestic basis, as well as commercial premises being the biggest benefactor. CCTV allows us to protect our homes, properties, businesses, cars, loved ones; it’s the ultimate in security!\nSo how can you get the most out of CCTV?\nThe main draw for using CCTV is to be a omniscient deterrent to potential thieves and troublemakers. The simple knowledge of having CCTV in as a visible presence can be enough to stop people in their tracks.\nPeople are aware they are being recorded/watched and that any actions they undertake could be prosecuted for crimes with incriminating video evidence.\nIf you are planning on installing CCTV at your home or business, think of the most valuable areas of your property or business – always postion CCTV at these key locations for the best protection.\nTo ensure you get the best out of your CCTV, Link Alarms would highly recommend the use of high-definition colour cameras. Should your home or business be involved in a criminal incident, a HD colour camera will provide the best quality evidence in a court of law, and prior to any legal proceedings, help the relevant authorities in identify the correct perpetrator. If you are still currently using black and white imagery, do not remove this system unless you intend to upgrade your system to HD colour.\nWe also recommend that you get your camera system from specialists like Link Alarms. Specialists like ourselves are able to provide the best equipment and provide installation in the optimal positions for your home or business.\nWe can provide full security audits to ensure each camera installed on your CCTV system is used to its advantage and that your home does not have any camera black spots. By doing this you will ensure your home is covered 24/7, 365 days a year, whether you are at home or not!\nFiled under: Alarms & CCTV Systems\nBack To News", "label": "No"}
{"text": "Letter from Peter McCahey to Robert Walker calling for an amnesty movement to be instigated for the Clan-na-Gael prisoners involved in an attack on the Welland Canal in 1900,\n1906 March 16.\nThis item is under copyright. The digital images may only be viewed via the online catalogue in the National Library Reading Rooms.\n|Main Creator:||McCahey, Peter|\nPaper embossed with stamp: \"Hamilton\".\nPhysical description: 1 item (2 pages).", "label": "No"}
{"text": "Real Country WCKA and Swimple Pools Present the Real Country Jukebox valued at over $3000 and growing everyday! Listen for the cue to call. Be the 9th caller to the contest line at 256-237-0810. Pick a song from the Jukebox below to be played on the air to reveal your qualifying prize. Can't call in?...Register below prior to the contest end date to be one of 10 instant qualifiers. All on-air and online qualifiers will go into a random drawing on April 29th, 2022 to win the GRAND PRIZE OF A 4 DAY/3 NIGHT VACATION AT THE HOLIDAY INN RESORT IN PANAMA CITY BEACH!\nAnd remember, only 1 qualifer per household!", "label": "No"}
{"text": "November 1st, 2018\n>>Opinion: Why Nov. 1 is the make-or-break day for the stock market\n>>The Big Tech Selloff\n>>October’s Market Rout Leaves Investors With No Place to Hide\n>>Global Stocks Haven’t Looked This Cheap Since 2016\n>>New Blue-Collar Jobs Will Survive the Rise of AI\nThe information contained in this letter is for informational and educational purposes only. It is not intended nor should it be considered investment advice or a recommendation of securities. Past performance is not a guarantee of future results. It is possible to lose money by investing. You should carefully consider your investment objectives and risk tolerance before investing. Please contact our office directly with any questions regarding items appearing in the letter.", "label": "No"}
{"text": "Left Aizu at 9.12am on the red train to Koriyama. Got kicked out of the reserve compartment so had to move to the unreserved carriage…well, I don’t read Japanese so had no idea it was reserved seating only.\nCaught the Shinkasen at Koriyama. While waiting for this bullet train, a train passed by at full speed. Omigod! the noise was terrifying as it passed by!\nWhen I got to Tokyo station there were signs to Narita Express, the train that I had to take to get to the airport. SOmetimes I lose the signs and had to ask. I met a lady from Sendai which is a town in the next prefecture (county) who had been in the uS for 30 years and now coming back to Japan. I told her that i was going to send Lucy to an international school in her town and she said she lived next to the school and that Lucy could stay with her. People are so nice here and polite too.\nI had to go deep into the bowels of the earth – three escalators down. Then when I got to the platform, I was still nervous about climbing onto the wrong train, but I soon found out that the electronic signs changes from Japanese to English every few seconds and it matches the ticket – train number, times etc. So that was ok. Once we got to Narita, it is the second stop I needed for the international departures and I had to go up five escalators (I think). Checking was easy and then I went to eat sushi for lunch at the sushi boat. lovely!\nI am back for just over a week. I arrived home the same day at 10 am but the flight to Reno was delayed two hours. Then we had a rip roaring flight from SF to reno . The plane was just landing when a gust of strong wind started rocking the plane and we were about 50 to 100 feet from the ground when the plane wings started tipping back and forth and bouncing around. Everyone was so quiet but I was screaming inside! So the pilot took off again. i could not believe it but we ended in Sacramento!! We had to wait for almost two hours ont he tarmac. They fuelled up and then just as we were about to take off the pilot said we are too heavy so they had to throw away some suit cases from the cargo!! everyone was craning their necks to see if it was their suit cases on the tarmac!!. finally, we took off and had a bit of a bumpy ride but we made it at about 8 pm!! We took off about 3.30pm from San Fran. Then there was a big accident on hi way 80 and that delayed us some more. By then I was starving but all the restaurants we went to in truckee were closed! It wasn’t Halloween yet already??!!", "label": "No"}
{"text": "Episode 192: Jenny Fischer – Love and Logic.\nOn Episode 192 of the Enormocast, I sit down in the Access Fund offices late night with Jenny Fischer. Jenny grew up and lived in the small city of Port Huron, Michigan until she was 30. Then she blew up her rather preordained life and lit out after a dream she’d had since she was … Continue reading \"Episode 192: Jenny Fischer – Love and Logic.\"\nDuration: 1 hr 24 min", "label": "No"}
{"text": "- This event has passed.\nNavigating a Changing World Lecture Series: A Tour Through Time\nMarch 29, 2017 @ 7:00 pm - 8:30 pm\nHumans are changing Earth’s natural systems in rapid and unprecedented ways. This has propelled our planet into a new geologic era: the anthropocene. How do we navigate these changes we’ve caused, where can we have positive impacts…and where do we find hope? We’re bringing in six experts with a diversity of perspectives to speak on these very things. Join us!\nOur first speaker is Kallie Moore, Collections Manager at the UM Paleontology Center. Join us for her lecture, A Tour through Time: Climate Change.\nTake a closer look at some of the dramatic changes in Earth’s climate during its 4.567-billion-year history, including our current climatic situation. Explore changes such as the oxygenation of the planet and the most recent ice age, as well as a preview into Earth’s possible future.\nCheck out our full list of speakers and topics here.\nCost per lecture: $10; $5 members; FREE for high school and college students\nPurchase tickets for multiple lectures and save!\nSpring or Fall series only (three lectures each): $20; $15 members\nEntire series: $30; $25 members\nPurchase tickets here. (We will also sell tickets at the door, but purchasing in advance will ensure you get a seat!)\nTicket includes beer and/or wine (if over 21); non-alcoholic beverages will also be available.", "label": "No"}
{"text": "Piano, guitar; acoustic and electric, my voice lol, and I dont know if you would classify it as an instrument but I also have my own studio wear I make progressive house music. I also plan on making a sound proof room and make a recording studio biggrin\nGuitar, Violin, Drums, Bass guitar and Piano.\nRight now I play my Travelers guitar a lot, because I perform in a lot of different places. It's a Martin.\nI have two electric guitars at home. One a Squier, and one a Schecter.\nI don't even know what kind of Piano I have at home, since it's not even mine (my sister's). I never take the time to find out what it's brand is, but when I'm traveling around, I use a Yamaha keyboard.\nI play piano and sing a little, got my beloved upright Steinway and Sons that I love as if it was my child, and my Yamaha p-140 that I use to write sometimes, and as a Synthesizer razz\nI also want to learn how to play Bass and Sax sometime in my life!\nI play a yamaha stage custom kit.\nAs well as playing an epiphone electric and yamaha LL acoustic.\nAnd a 'royal' accordion. samira ukulele. various other instruments, all for many years.\nmusic is the rock on which I stand\nI'm a trumpet player. Loving every minute of it too. I also sing. A LOT. I also play a little guitar. Kinda play the flute and drums. I'm very talented!!! heartrofl4laughdramallamabiggrincoolemotion_dealwithitgaia_diamondgaia_diamondcat_talk2hand", "label": "No"}
{"text": "GameInformer has provided some hands-on first impressions of Marvel’s Spider-Man: Miles Morales, one of the PlayStation 5’s most exciting launch titles. According to their report, Insomniac Games has crafted “a true sequel that will likely set the stage for what comes next.”\nMiles played a significant role in the events of 2018’s Marvel’s Spider-Man. He befriended Peter Parker after his father’s death, and was briefly playable in a stealth segment before being bitten by a genetically modified spider; the two Spider-Men revealed their powers to each other in the epilogue. Now a year has passed and Miles is coming into his own identity as the webslinger with Peter as his mentor.\nInsomniac has reflected Miles’ inexperience in his animations. “We knew he was still learning his abilities and figuring out how he would be Spider-Man,” director Cameron Christian told GameInformer. “If you look at his motion, he’s a little less sure, a little more gangly.” In fiction, Peter has been using his powers to fight crime for many years, while Miles has barely a year to get the hang of it.\nPeter will serve as a mentor from the sidelines throughout the game’s events, but joins in the game’s first boss fight. Mirroring the way Kingpin served as the original game’s tutorial, Miles goes toe-to-toe with a returning villain with Peter’s help; after apprehending some escaped inmates, Miles switches places with Peter to face the boss.\nMiles Morales has his own set of powers and gadgets at his disposal. Most prominent are his Venom powers — not referring to the beloved symbiotic villain, but to the stinging nature of Miles’ unique spider powers. These electric attacks will be accessed by holding the L1 button and pressing different face buttons, similar to the Focus system in the first game; L1 + Square, for instance, unleashes a Venom Punch. Enemies hit by these attacks gain a Venom Stun effect, which makes them susceptible to follow-up attacks. GameInformer noted that haptic feedback in the DualSense controller accompanies the Venom charge.\nOf course, there are enemies along the way which can resist these specialized attacks. The corrupt Roxxon corporation’s thugs “have anti-Miles abilities,” says creative director Brian Horton.\nMany of the activities from the first game return with revisions, like stopping crimes in progress, finding new collectibles, and solving puzzles, but the minigames from Dr. Octavius’ lab are gone (for obvious reasons). Miles will have a “Friendly Neighborhood Spider App” on his phone, developed by his friend Ganke Lee, to track missions, replacing the menu-based map and police scanner from Peter’s journey.\nMarvel’s Spider-Man offered a terrific open-world rendition of New York City, which returns in Miles Morales; however, as Miles now lives in Harlem, that particular neighborhood has been greatly redesigned, fleshing out details and emphasizing its real world culture. Crime rates and collectibles are divided by district once again.\nThe plethora of suits at Peter’s disposal were a big highlight, and Miles should have a comparable wardrobe — although the character does not have the same publication history as the original webslinger, and has fewer iconic looks to draw from. GameInformer saw at least six suits in their time with the game, including a more casual look with a hoodie (reminiscent of what the character wore in 2018’s Spider-Man: Into the Spider-Verse); his iconic black-and-red suit; a more pajama-like red-and-blue suit; a LED-heavy outfit dubbed the “2020 Suit,” from a recent comic cover; and the preorder bonus T.R.A.C.K Suit, designed by artist Javier Garrón.\nBy all indications, Marvel’s Spider-Man: Miles Morales is shaping up to be a worthy successor to Insomniac’s first outing, adding a fresh spin on the engine for a new character. Players can see for themselves when the game launches alongside the PlayStation 5 on November 12, alongside Marvel’s Spider-Man Remastered.", "label": "No"}
{"text": "Convolutions are preferred because they capture global translational invariances.\nA layer with Local receptive fields (LRF) which does not share weights across the entire input structure does not capture them.\nIn the second link that you cite, the proposed model does not need such invariance because it is applied to a face recognition problem for which the images are centered.\nIn particular, each LRF is associated to the same kind of region for each image. A LRF in the hair would capture information very different from a LRF in the eye for example, thus it makes little sense to make them share weights.\nCertainly this implementation is clever for this type of dataset but is at a greater computational cost.\nIn the first link, there is actually weight sharing. The parameter $k$ controls the number of steps away the weights of a LRF are shared with another LRF, allowing them to capture the wanted translational invariances as well as other additional invariances.\nThey showed that their model works best for $k=2$. In this case, the number of parameters is only doubled (a LRF has its weights shared with half of all LRF).\nA good explanation about parameter sharing can be found on wikipedia's cnn article.", "label": "No"}
{"text": "Compare book prices\nat 110 online bookstores\nworldwide for the lowest price for new & used textbooks and\ndiscount books! 1 click to get great deals on cheap books, cheap\ntextbooks & discount college textbooks on sale.\nReason, Culture, Religion: The Metaphysics of World Politics (Culture and Religion in International Relations)\nReason, Culture, Religion book provides a systematic overview of the study of world politics. The author then locates modernist world politics in its sacral context by discussing Taoist strategics, Buddhist economics, Islamic civics, Confucian Marxism, Hindu constructivism, Pagan feminism and Animist environmentalism. It concludes by asking what a world affairs worthy of the name would be.\nRecent Book Searches:\nISBN-10/ISBN-13: 0816183538 / 978-0816183531 / Sir Thomas Elyot and Roger Ascham, a Reference Guide (Reference Publication in Literature) / Jerome Steele Dees 081618397X / 978-0816183975 / Robert Frost Studies of the Poetry / K. Harris 0816184186 / 978-0816184187 / Nigerian Literature: A Bibliography of Criticism, 1952-1976 (Bibliographies and guides in African studies) / Claudia A. Baldwin 0816180024 / 978-0816180028 / The History of Sub-Saharan Africa: A Select Bibliography of Books and Reviews, 1945-1975 (Reference Guides in Literature; No. 16) / William E. Martello 0816180555 / 978-0816180554 / Lloyd Alexander, Evangeline Walton Ensley, Kenneth Morris: A Primary and Secondary Bibliography (Masters of Science Fiction and Fantasy) / Kenneth J. Zahorski, Robert H. 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Hinnant 0816181888 / 978-0816181889 / Brazil: A Handbook of Historical Statistics (Reference Publication in International Historical Statistics) / Armin Ludwig 0816182140 / 978-0816182145 / Herman Melville's Foreign Reputation: A Research Guide (A Reference publication in literature) / Leland R. Phelps 081618223X / 978-0816182237 / Contemporary American Composer: A Biographical Dictionary / E. Ruth Anderson 0816183562 / 978-0816183562 / Middle Scots Poets: A Reference Guide to James I of Scotland, Robert Henryson, William Dunbar, and Gavin Douglas (Reference Publication in Literature) / Walter Scheps, J. Anna Looney 081618111X / 978-0816181117 / Arthur C. Clarke: A Primary and Secondary Bibliography (Masters of Science Fiction and Fantasy) / David N. Samuelson 0816181551 / 978-0816181551 / Ursula K. Le Guin: A Primary and Secondary Bibliography (Masters of science fiction and fantasy) / Elizabeth C. Cogell 0816181756 / 978-0816181759 / Rare Afro-Americana: A Reconstruction of the Adger Library (Reference Publication in Black Studies.) / Wendy Ball, Tony Martin 0816181861 / 978-0816181865 / Index to Black American Literary Anthologies (Bibliographies and Guides in Black Studies) / Jessamine S. Kallenbach 0816182450 / 978-0816182459 / Bibliographies on South African Political History: General Sources on South African Political History Since 1902 / D. Geyser 0816182582 / 978-0816182589 / Critical Essays on Arthur Miller (Critical Essays on American Literature) / 0816182612 / 978-0816182619 / Critical Essays on William Styron (Critical Essays on American Literature) / Arthur D. Casciato, James L. W. West 0816183074 / 978-0816183074 / Critical Essays on Frank Norris (Critical Essays on American Literature) / 0816183163 / 978-0816183166 / Early Christian and Byzantine Architecture: An Annotated Bibliography and Historiography (Reference Publication in Art History) / W. Eugene Kleinbauer 0816183309 / 978-0816183302 / French Romanesque Sculpture: An Annotated Bibliography (Reference Publications in Art History) / Thomas W. Lyman, Daniel Smartt 0816183368 / 978-0816183364 / Critical Essays on Phillis Wheatley (Critical Essays on American Literature) / William H. Robinson 0816183988 / 978-0816183982 / A Reader's Guide to the Short Stories of Nathaniel Hawthorne (Reference Publication in Literature) / Lea Bertani Vozar Newman 0816184313 / 978-0816184316 / The James-Hawthorne Relation: Bibliographical Essays / Thaddeo K. Babiiha 0816184445 / 978-0816184446 / Critical Essays on F Scott Fitzgerald's Tender Is the Night (Critical Essays on American Literature) / 0816184518 / 978-0816184514 / Thomas Gray: A Reference Guide (A Reference guide to literature) / Alan T. McKenzie\nMore About Using This Site and Buying Books Online:\nBe Sure to Compare Book Prices Before Buy\nThis site was created for shoppers to compare book prices and find cheap books\nand cheap college textbooks. A lot of discount books and discount text books\nare put on sale by many discounted book retailers and discount bookstores everyday.\nYou just need to search and find them. Our site provides many book links to\nsome major bookstores for book details and book coupons. But be sure not just\njump into any bookstore site to buy. Always click \"Compare Price\" button to\ncompare prices first. You would be happy that how much you could save by doing\nbook price comparison.\nBuy Books from Foreign Country\nOur goal is to find the cheapest books and college textbooks for you, both\nnew and used books, from a large number of bookstores worldwide. Currently our\nbook search engines fetch book prices from US, UK, Canada, Australia, New Zealand,\nNetherlands, Ireland, Germany, France, and Japan. More bookstores from other\ncountries will be added soon. Before buying from a foreign book store or book\nshop, be sure to check the shipping options. It's not unusual that shipping\ncould take 2 -3 weeks and cost could be multiple of a domestic shipping charge.\nBuy Used Books and Used Textbooks\nBuying used books and used textbooks is becoming more and more popular among\ncollege students for saving. Different second hand books could have different\nconditions. Be sure check used book condition from the seller's description.\nAlso many book marketplaces put books for sale from small bookstores and individual\nsellers. Make sure to check store review for seller's reputation when available.\nIf you are in a hurry to get a book or textbook for your class, you would better\nchoose buying new books for prompt shipping.\nPlease See Help Page for Questions\nregarding ISBN / ISBN-10 / ISBN10, ISBN-13 / ISBN13, EAN / EAN-13, and Amazon", "label": "No"}
{"text": "2012 is the 50th Anniversary of Wildlife Queensland, and we had good reason to celebrate here in the Scenic Rim, where co-founder, president and patron Judith Wright lived for many years (on Tamborine Mountains) and wrote many of her poems, and where the early WPSQ Spring Schools were held (at Binna Burra, on the edge of Lamington National Park). I flew up from Adelaide to attend one of these Schools in the late 60’s, and felt very privileged to be able to walk and talk with Judith (whose poems had been amongst my favourites amongst those I had studied at school) on the rainforest tracks.\nOur major local celebration this year was the Wild Talent evening 22nd September, featuring Judith Wright’s life and poetry, and wildlife-related poetry and artwork by some of our talented local residents at the Centre, Beaudesert.\nOur club poet Brett Dionisyus recited several of his own poems as well as several by Judith Wright, and he and Ronda both spoke briefly of Judith’s life in the Scenic Rim\nSara Bruxner attended, and several of her poems were read out by Darren and Ronda Green. Darren and Ronda also read poems by Susan Savage, who unfortunately was unable to attend in person, and presented a recorded song by Ronda (written as a teenager) about wildlife and conservation.\nSee https://branches.wildlife.org.au/scenicrim/poems.html for some poems by Brett and Sara.\nJoy Drescher, Cristine Purtie and Sandra Rose displayed some of their artwork, and we also showed photos by Darren Brown who was also unable to attend.\nWe enjoyed drinks and nibbles including a celebratory chocolate mud cake.\nAltogether a very enjoyable and varied evening.", "label": "No"}
{"text": "Home Renovations – Tips To Create Your Own Oasis\nHome improvement projects usually have to be done in order to add new features and to update your house. There are many projects that you can complete on your own, eliminating the need to hire someone else. The following article will give you some great tips on how you can complete these projects.\nRegularly changing the air filters in your home is very important. Clean air is healthy, plus appliances like the furnace will work more efficiently. Blocked filters are a common cause of calls to repair people.\nWeather stripping is important to include around your windows for energy efficiency. This is an inexpensive material purchased at the home improvement store, and seals out exterior cold and hot air to stabilize inner temperatures so that your heater and cooling systems do not need to work as hard. Also, this helps to reduce drafts for a better living environment.\nWhenever you need to go the home improvement store, it is best that you have a checklist of all the things you have to use. If you make a list of things you need, you will not have to go back.\nAdd exhaust fans to high moisture areas, such as bathrooms, cooking areas, and laundry rooms. You can reduce the occurance of mildew and mold in your house by keeping moist air out. In addition, lower indoor humidity can keep moisture from being trapped inside walls, a leading cause of rot.\nIf you want to use a wood fireplace to heat your home, you should understand that it is not the best idea. While aesthetically pleasing, they are not overly efficient. Fires also require a lot of oxygen to burn properly, a lot of wood to keep going, and the wood produces a lot of soot and grit. It’s just not very appealing.\nThere isn’t a lot of natural light in most basements, if any at all. To increase your enjoyment of any basement finishing project, carefully consider the layout of the lighting you use. Many basements are located only partially underground. In this case, you can have windows as well.\nUse natural products for your design elements if your budget allows. Genuine building materials such as stone, wood or ceramic are nearly always superior to the synthetic versions. They look better and last longer. Choosing natural materials over synthetics can prove more cost effective as synthetics will need replacement more frequently.\nWise homeowners spend their money on materials and fixtures that are high in quality instead of buying expensive furniture. The reason is because homeowners take their furnishings with them. For example, a quality front door and hardwood floors will bring a much larger price than holding an open house with a designer sofa.\nIt need not be impossible to add the features that you want to your home. You can do a lot of things yourself with a little research. Follow this advice and get started.\nMany people would like to understand kitchen cupboard designs, but they don’t always know how they should go about it. You have found the information you require to get going, right here in this article. Simply make the best use possible of this valuable information.", "label": "No"}
{"text": "jayson I posted cast iron basics in another post from my book. here is the seasoning section for you. if you have more questions ask away or pm me.\nCast Iron Basics\n(Some of the most important things you need to know!)\nSeasoning: Cast iron may be heavy, but with a proper seasoning, it is the greatest type of metal to cook in. But, you need to keep your cast iron free from rust and well seasoned to make it “stick free”.\nWhen someone buys cast iron from the store, the foundry (manufacturer) coats the pot or pan with a coating of some sort to keep the item from rusting. This is done by spraying with a type of varnish or dipping it into hot paraffin wax. This protective coating must be cleaned off before seasoning your cast iron.\nIf your Dutch oven is made by LODGE, the protective coating is a sprayed varnish coating, which must be scrubbed off. Heat the Dutch oven inside your home oven to 225oF. then with a hot pad, lower the oven into hot soapy water, and scrub the Dutch oven with a S.O.S. pad. Scrub the inside and outside of the Dutch oven very well, rinse well, and towel dry. Then place the Dutch oven back into your oven at 225° to dry for about 10 to 15 minutes. The only way to dry cast iron is to dry it completely. I do mine in the oven because; the heat is not concentrated in one spot, as it is on the stove top, which can cause minute cracks.\nIf your Dutch oven is made by any of the other companies that make outdoor Dutch ovens, the protective coating is dipped paraffin wax, which can be burned off. Do this outdoors in your gas B.B.Q. or, a kettle type charcoal B.B.Q. like a Webber. In a charcoal B.B.Q., use Mesquite charcoal for fuel because it burns much hotter than briquettes. Start the charcoal or light the gas B.B.Q., set on high and pre-heat the B.B.Q. When the charcoal is white, spread it out a little so that is not to close to the cooking grate. Place the oven onto the cooking grate, upside down, and close the lid on the B.B.Q.\nHeat the oven to 500° to 550° for 15 minutes. Close the B.B.Q. and cook the Dutch oven for about 1 hour at 500° to 550°, or until the oven stops smoking. Cool the scrub the oven and dry as directed above.\nNew and recent developments include “pre-seasoned” cast iron. If this is the case for you and your new Dutch oven or cast iron implement then you should still season the implement before you use it to cook and prepare food. Having pre-seasoned cast iron is much easier to prepare for your first initial seasoning in that, all you need to do is remove the cast iron from the box and wash it with very hot soap and water and rinse it well. Then, you can follow the directions below and season your cast iron, then use it to make delicious food for you, your family and friends.\nTo season the Dutch oven, place the oven upside down on the cooking grate and warm the oven for 10 to 15 minutes at 500° to 550°. With hot pads, remove the D.O. and rub a light coat of lard, bacon grease, white Crisco, or vegetable oil, using a paper towel.\nCoat the inside and outside of the D.O. and lid. You only need a light coat of oil; you don’t want the grease to be dripping off the oven. Only apply enough fat to make the iron look wet. Place the Dutch oven back onto the cooking grate and cook the Dutch oven for about 1 hour at 500° to 550°, or until the oven stops smoking. Remove the oven from the B.B.Q. with hot pads to cool. If the D.O. is a glossy brown color, not black, return to B.B.Q. to cook about thirty more minutes. By doing this outside in the B.B.Q., you don’t have to fill the house with smoke and set off the smoke detectors.", "label": "No"}
{"text": "At Maine Heat Pumps & Services, we offer complete installation of industry leading, high efficiency heat pump systems to both residential and commercial customers across the great state of Maine.\nWe take pride in our convenient installation process and competitive affordability. Our units operate in both cooling and heating modes so you can stay cool all summer and warm all winter. And you can have peace of mind knowing that with Mitsubishi’s Hyper Heating Inverter you can keep cozy even when the true outdoor temperature reaches down to -13°.\nOur knowledgeable technicians also provide full maintenance and servicing for the entirety of your heat pump system, including diagnosing mechanical issues and annual cleanings, so you can rest assured knowing that your system will be running smoothly and efficiently around the clock. Whatever your needs, our goal at Maine Heat Pumps & Services is to provide every customer with a pleasant experience from start to finish, and peak comfort regardless of the conditions outdoors. (transcript of video below)", "label": "No"}
{"text": "If you haven’t checked out Duke Bakery I would highly recommend it.\nThey have some combinations that you won’t find anywhere else and are often a pleasant surprise. Tuna cheese bread anyone?\nI visited the location in Rowland Heights. If you are looking for properties along the 60 Freeway I can help you search there as well. Just check out the Emilie Broughton.com search page and set up your search criteria!", "label": "No"}
{"text": "KIA SORENTO 2007 2008 2009 FACTORY SERVICE REPAIR MANUAL\nKia Sorento 2005 2006 2007 Service Repair Factory Manual\nMay 30, 2012KIA Sorento 2006 KIA Sorento 2007 KIA Sorento 2008 KIA Sorento 2009. 1 manual for each year consisting of, 2×4/4×4, all trim/engines for USDM design. Initial Factory 2002-2009 Kia Sorento Service Repair Manual is a Complete Informational Book. This Service Manual has easy-to-read message areas with premium layouts and also directions.\nKia Sorento Service Repair Manual - Kia Sorento PDF Downloads\nKIA Sorento 2007 2008 2009 Factory Service Repair Manual KIA Sorento BL 2 2003-2007 Service Repair Workshop Manual Download PDF KIA SORENTO Body 2003-2008 Service Repair Workshop Manual\nService & Repair Manuals for Kia Sorento for sale | eBay\nNew Listing Kia Sorento 2007 2008 2009 Factory Service Repair Manual. $8. From Hungary. Free shipping. Watch. Kia - Service and Repair Manual 30 Day Online Access (Fits: Kia Sorento) Digitally delivered in minutes. Powered by Identifix. $6. Make: Kia. Free shipping. 113 sold.\nKia Sorento 2008 2009 Service Workshop Repair Manual\nKIA Sorento 2003-KIA Sorento 2004-KIA Sorento 2005-KIA Sorento 2006-KIA Sorento 2007-KIA Sorento 2008-KIA Sorento 2009. 1 manual for each year consisting of, 2×4/4×4, all trim/engines for USDM design. Initial Factory 2002-2009 Kia Sorento Service Repair Manual is a Complete Informational Book.\nKia | Sorento Service Repair Workshop Manuals\n2003-2008 Kia Sorento Service Repair Manual. $17. VIEW DETAILS. 2003-2009 KIA Sorento Factory Service Repair Manual backing up, and more. Use the Kia Sorento service manual to your advantage when it comes to finding out more about the interior and exterior of your vehicle. 2003-2009 KIA Sorento Factory Service Repair Manual. KIA\nKia Service Repair Manual PDF\nKIA Borrego 2009-2010 OEM Factory SHOP Service manual Download FSM *Year Specific Download Now Kia Borrego 2009 2010 4 Workshop Service Manual Download Now KIA Borrego 2010 Service Repair Manual Download Now\nKia Sorento: Normal maintenance schedule - Maintenance\nKia Sorento: Normal maintenance schedule Second Generation XM (2011-2020) / Kia Sorento XM Owners Manual / Maintenance / Maintenance service / Normal maintenance schedule The following maintenance services must be performed to\nKIA Factory Repair Manuals\nCustomers who are the owner of Optima, Cadenza, Sorento, Soul, Sportage, Rio, Forte, Soul EV or any other model are offered quality repair manual according to VIN, manufacturing year and model. There are many websites where free of cost service manual is provided to use for all make and models.\nKia Sorento Free Workshop and Repair Manuals\nKia Sorento The Kia Sorento is a mid-size crossover SUV produced since 2002 by the South Korean automaker Kia. Debuting in 2002, the first generation Sorento was a traditional truck-based body-on-frame SUV. It was offered in two trim levels: LX and EX.\nKia Sorento - Wikipedia\n2007–2008 Kia Sorento LX (US) 2009 Kia Sorento EX (Australia) Georgia, factory (which also builds the sister vehicle to the Sorento, the Hyundai Santa Fe). The second generation used Kia's corporate Tiger Nose grille, and was the first Kia vehicle to offer Kia UVO.\nRelated searches for kia sorento 2007 2008 2009 factory service\n2008 kia sorento reviewskia sorento 20072008 kia sorento for sale2007 kia sorento parts2007 kia sorento reviews2007 kia sorento for sale2008 kia sorento lx2007 kia sorento value", "label": "No"}
{"text": "We Dont Want to Miss Out on Sharing Your Parenthood Journey\nCovid-19 has affected so many in so many ways.\nFor Common Moms it means stopping all that we do. It means closing our doors at The Family Room and not being able to support parents and their little ones.\nWe miss you all so much and we want nothing more than to see you when this is all over but we need your help. We won't be able to survive keeping our community running without funding.\nWe are turning to our families who have grown along side us, whose lives we have impacted and ones that want to join us on the amazing journey together.\nWe realize this is a trying time for all but if you can support us by any denomination we promise to continue providing programming, events and support to parents and their little ones!\nThank you and stay safe.", "label": "No"}
{"text": "Sam Loyd Puzzles\nChoose the Right Symbol Puzzle\nWhat mathematical symbol can be put between 5 and 9, to get a number bigger than 5 and smaller than 9?\nDo you have the answer? Check against\nCopyright © 2018 MathsIsFun.com", "label": "No"}
{"text": "Anderson County Schools’ energy upgrades saving more than forecast\nCLINTON — An ambitious energy conservation project involving all 17 schools in the Anderson County school system is paying dividends, and that payoff is more than forecast.\nThe company that put the variety of energy-saving measures in place predicted savings of $463,369 for the first nine months the project was in place. The school system accepted the work last July.\nBut through March 31, the savings totaled $555,886, or 120 percent of what was expected, said James T. Woodward Sr., the school system's chief financial officer.\n'This was a good move on our part,' said Woodward. 'We want to brag on this program.'\nAnderson County Commission in 2014 approved a 15-year contract with Energy Systems Group to put a $9.6 million energy efficiency project in place, with expected savings earmarked to pay for the program.\nBoiler systems were replaced at five schools, heating and cooling systems were upgraded, sensor systems were installed to automatically turn off lights and heating and cooling systems when rooms are unoccupied.\nSingle-pane windows at four schools were replaced with more energy-efficient windows, water conservation measures were implemented, and new suspended ceiling systems were installed.\nThe program even paid for front entrance buzz-in security systems at all schools.\nA 35-year-old transformer at the Anderson County High School campus, which also serves the county's vocational-technical center and the new Clinch River Community School, was replaced with a smaller, more efficient transformer, Woodward said.\nOverall, Energy Systems Group is guaranteeing the school systems will save $561,884 annually. Those savings will be used to pay for the program.\n'We don't have to put money into the budget to pay for it,' Woodward said.\n'I think this is going to produce real positive benefits for us for a long time to come,' he said, adding that the upgrades also provide 'a much more efficient educational environment.'\nEnergy Systems Group is guaranteeing the county school system will save at least $561,884 a year with the energy upgrades, and the savings are closely monitored.", "label": "No"}
{"text": "IBM's Santa Teresa complex is built on a 1,180-acre site in San Jose's foothills, a beautiful natural setting, of which 90 percent is set aside as open space. The facility, designed by MBT Architecture, houses 2,200 persons engaged primarily in computer programming and related services. This large complex solves a long list of seemingly insurmountable problems. These included designing for a beautiful but earthquake prone natural setting; providing a large group of technical people with both extreme efficiency and human comforts; and meeting the highly specialized and demanding requirements of computers.\nThe campus like facility consists of eight cruciform shaped, four story buildings clustered tightly around a plaza and a 45,000 sf computer center. This center has one of the largest computer capabilities in the world. Support services are extensive and include a library, combination dining and meeting rooms, specialty conference and classrooms, a large reproduction facility, medical facility, employee services, recreation building, and maintenance facility.\nThe design of an efficient circulation pattern became extremely important once the campus configuration was selected. All buildings are linked beneath a second level, landscaped plaza which is a prime contributor to the non-institutional atmosphere of the complex. Most of the buildings are also linked by bridges at the upper floor levels. The core of each building contains the stairwells, elevators, restrooms, and administrative support centers, and is surrounded by a primary circulation corridor. Radiating from the core are identical wings of private offices and conference and computer terminal rooms.\nThe clustering pattern of three buildings, offset from the other five, marks the entrance from the visitor parking area and reduces the scale of the complex from the road. This organization opens up vista corridors diagonally and at right angles throughout the complex. Views to the surrounding hills and nearby valley are emphasized architecturally by the pattern of walkways on the plaza level.\nEach building is color coded with brilliant colors; magenta, red, red-orange, yellow, green, teal, and blue, for easy building identification. On the exterior, the color coding exists only to where the wings of two structures join to form a courtyard. Therefore, each courtyard has a predetermined, complementary pair of colors. The interiors of the buildings are also completely color coded, from office tackboards to stairwells.\nFaced with the challenge of siting a major computer facility in seismically active area, the MBT Architecture team designed the complex to accept earthquake forces determined by seismic analysis of the nearby faults including the immediately adjacent Shannon Fault. The facility utilizes steel frame structures that are highly flexible and capable of moving relatively freely under severe seismic conditions. The design incorporates lightweight, custom aluminum curtain wall panels, with flush glass floating in sealant with no mechanical restraint.\nEnergy conservation is achieved through exterior heat reflection, daylighting, earth insulation, internal heat recovery and special mechanical system controls. The mirrored glass walls and the burial of the first floor dramatically reduce external heat gain; the immediate proximity of the majority of offices to large windows permits minimum heat gain from lights. All space heating and water heating is by heat recovery from the computers and lighting fixtures. The variable volume system is computer controlled for optimal efficiency.\nThe development of the project involved rigorous fast tracking. Occupancy of the facility in 1977 occurred less than three years after the request for proposal was sent. The schedule was met, even though the project required such special services as an Environmental Impact Report, master planning, programming, furniture design and art selection, as well as 11 major construction contracts and several dozen minor contracts.\nCreated: October 15, 1997", "label": "No"}
{"text": "If the people you love are jerks, you should get a Bluey Behind Every Bad B*tch Is A CarSeat Shirt that says that. If the people you love are bad drivers, then it’s time to get your bluey behind a seat.\n|Size||From S to 5XL|\n|Style option||T-shirts, Hoodies, Tank Tops, Youth Tees, Long Sleeve Tees, Sweatshirts, Unisex V-neck...|\n|Shipping||From the USA|", "label": "No"}
{"text": "224 pages , 2012-01-01 As our relationship with the world unravels and needs to take a new form, The Wanton Green presents a collection of inspiring, provoking and engaging essays by modern pagans about their own deep, passionate and wanton relationships with the earth. \"Where do we locate the sacred? In a place, a meeting, memory, a momentary glimpse? The Wanton Green provides ...[Read More]\n163 pages , Prentice Hall , 2007 This book provides a framework for business ethics in the age of sustainability. The book examines the many ways that business is changing, and should change, to meet the demands of a sustainable future. This book blends philosophical and ethical analysis with real-world practical cases and examples to show what sustainable business can a...[Read More]\n256 pages , Oxford University Press , 2010-03-18 Here is a refreshing look at how American cities are leading the way toward greener, cleaner, and more sustainable forms of economic development. In Emerald Cities, Joan Fitzgerald shows how in the absence of a comprehensive national policy, cities like Chicago, New York, Portland, San Francisco, and Seattle have taken the...[Read More]\n500 pages , Woodhead Pub Limited , 2001 A definitive reference source to the scrap and recycling industry worldwide. It covers the major recyclable materials, from metals to plastics, paper and pulp, rubber and glass. For each material SRH provides: An analysis of its physical characteristics; A description of its properties, products and end uses; Information on product...[Read More]\n32 pages , Macmillan , 2006-04-04 Ready to lay eggs of her own, a female turtle heads to shore to find just the right nesting place, but crossing the busy road is very challenging and so she happily accepts a little help from some obliging humans to get the job done.\n560 pages , Elsevier , 2002-08-22 The Handbook of Air Pollution Prevention and Control provides a concise overview of the latest technologies for managing industrial air pollution in petrochemical, oil and gas, and allied industries. Detailed material on equipment selection, sizing, and troubleshooting operations is provided along with practical design methodology. Uniqu...[Read More]\n434 pages , Springer Science & Business Media , 2005-03-30 The plant fossil record indicates that the genus Metasequoia was widely distributed throughout the Northern Hemisphere from the early Late Cretaceous to the Plio-Pleistocene. Today the genus has shrunk to one species with approximately 5,000 mature individuals in southeastern China’s Xiahoe Valley. This bo...[Read More]\n878 pages , Elsevier , 2013-10-02 Mediterranean Coastal Pollution focuses on scientific and technical information on the progress of measures and initiatives relative to the control of pollution in the Mediterranean. The book commences by pointing to the Mediterranean Action Plan. Particularly given consideration are the related legislation, the environmental assessment ...[Read More]", "label": "No"}
{"text": "Understanding social circumstances of the veteran population\nThis study aims to provide an overview of the social circumstances of the Scottish veterans population and to compare and contrast their situation to a comparable group of people drawn from the general population.\nReducing economic inactivity\nThe focus of this study is to understand groups within the Northern Ireland working age population who changed their economic activity status between 2001 and 2011.\nInvestigating Irish language and Ulster Scots in Northern Ireland\nThis research project will assist policymakers in understanding the factors that influence Irish language and Ulster Scots speaking in Northern Ireland.\nUnderstanding users of concessionary fares\nThe aim of this research is to analyse the profile and rates of uptake and use of SmartPasses by the population aged 60 and over in Northern Ireland.\nUnveiling trends in drug-related deaths\nThis research will generate more extensive socio-economic, health and equality group related information to better understand adverse trends in drugs and alcohol mortality in Northern Ireland.\nMaternal employment in Northern Ireland\nThis project aims to maximise the research impact of previous work examining factors affecting mothers' return to work (or not) after having children in Northern Ireland.\nDental and ophthalmic health provision for people with severe mental illness\nAn examination of disparities in rates between those with severe mental illness and the general hospital population in Northern Ireland.\nPhysical healthcare outcomes for people with severe mental illness\nThe study aims to provide evidence about the medical outcomes of people with severe mental illness (SMI) in Northern Ireland.\nHealth service use and outcomes in later life\nIn a Northern Ireland context, this study will provide an opportunity to examine later-life health inequalities related to service use.", "label": "No"}
{"text": "In the realm of manufacturing and fashion, fabric selection plays a crucial role in determining the quality and appeal of the end product. One such fabric that has gained considerable attention in recent years is tricot back fabric. Its unique structure and properties make it an ideal choice for a wide range of applications in various industries. In this article, we will delve into the world of tricot back fabric and explore how it can be used to propel businesses towards success. Understanding Tricot Back Fabric: Tricot back fabric is a type of knit fabric characterized by its distinct structure and texture. It is produced on a warp knitting machine using a specific stitch configuration, resulting in a fabric with fine vertical ribs on one side and a flat, smooth surface on the other.\nThis dual-sided nature of tricot back fabric allows for multiple uses and enhances its versatility. Superior Comfort and Softness: One of the primary reasons why tricot back fabric has garnered a loyal following in the textile industry is its exceptional comfort and softness. The smooth side of the fabric sits next to the skin, providing a gentle contact surface that feels pleasant to touch. This unique characteristic makes tricot back fabric an excellent choice for garments that require prolonged wear, such as activewear, intimate apparel, and baby clothing. Moisture-Wicking and Breathability: Tricot back fabric possesses excellent moisture-wicking capabilities due to its knitted construction.\nThe fabric’s inherent ability to draw moisture away from the body helps to keep the wearer dry and comfortable, even during intense physical activities. Additionally, the knit structure allows air to circulate freely, promoting breathability and preventing overheating. This makes tricot back fabric an ideal choice for sportswear, outdoor gear, and even upholstery applications where breathability is essential. Durability and Performance: Another notable advantage of tricot back fabric is its exceptional durability and overall performance. The knit structure of the fabric provides it with inherent strength and resistance to tearing and snagging, making it well-suited for applications that demand longevity. Tricot back fabric also offers excellent color retention, resisting fading even after repeated washing and exposure to sunlight. These properties make it a preferred choice for automotive upholstery, outdoor furniture, and other heavy-duty applications.\nVersatility in Design and Innovation: Tricot back fabric’s versatility extends beyond its physical properties to its adaptability in design and innovation. The smooth side of the fabric can be printed, dyed, or embellished with various patterns, enabling designers and manufacturers to create unique and visually appealing products. From vibrant sportswear to elegant lingerie, tricot back fabric opens up a world of possibilities for businesses looking to bring their creative visions to life. Conclusion: Tricot back fabric represents a game-changing material that businesses should consider incorporating into their product lines. With its combination of superior comfort, moisture-wicking properties, durability, and versatile design options, tricot back fabric offers immense potential for success across multiple industries. By harnessing the unique qualities of tricot back fabric, businesses can provide their customers with high-quality products that not only fulfill functional needs but also deliver a delightful sensory experience.", "label": "No"}
{"text": "Posted by Guy Malachi\nIn this great presentation from TED, Dan Ariely demonstrates how easily we are guided into making specific decisions, all while being under the illusion of being in control (not me of course :).\nHere are some of the highlights, excuse the crappy screenshots (the entire 17 minute video is embedded below).\nIn a survey among different countries the percentages of people willing to donate their organs varied quite a bit:\nWhen checking to see why there were such differences between countries, they checked for cultural differences between countries and saw there was no correlation (Austria and Germany for example are culturally similar but have totally different percentages of organ donors).\nThe answer came from checking the donor form at the DMV.\nIn some countries (the ones with the low organ donor rate) there was a section like this in the form:\nIn other countries the same question would appear but with a slight variation:\n(This is a classic opt-in vs. opt-out decision used in almost all online forms)\nAnother example he gives is in this sign up form for a newspaper:\n2. is a print only subscription\n3. is both web and print subscription for the exact same price as option 2\nWhen presented with these 3 options, these were the percentages of people's choices:\nSo the middle option is useless (nobody chose it) and can be removed, right?\nLook what happened when it was removed and only option 1 and 3 were offered:\nSo by offering a \"useless\" option, that nobody chose, the perceived value of the third (more expensive) option went up and more people chose it (because they believed they were getting more for the same price).\nThat \"useless\" option made more people pay $125 instead of $59.\nNot bad, ah?\nCheck out the entire video:", "label": "No"}
{"text": "- This event has passed.\nCognitive Changes in Healthy Aging and Early Stage Alzheimer’s Disease\nTuesday, July 19, 2011 @ 1:00 PM-3:00 PM\nFeatured Speaker: David Balota, Ph.D., Professor of Psychology and Neurology, Department of Psychology, Washington University in St. Louis\nWashington University Psychology and Neurology Professor, Dr. David Balota, covers recent advances in our understanding of the changes that occur in memory and attention in both healthy aging and early stage Alzheimer’s disease. He talks about the underlying neural changes that appear to account for these changes and provides an overview of possible lifestyle factors that appear to mitigate changes in memory and attention.\nTo be held at:\nOASIS at the Center of Clayton\n50 Gay Avenue, Clayton, MO 63105\nFREE to the first 10 registrants, $9 per person thereafter. OPEN to ALL. Space is limited.\nTo register call 314-533-8586 or e-mail firstname.lastname@example.org\nOn Science Series co-sponsor:", "label": "No"}
{"text": "Global Expansion Marks 10th Anniversary of Leading Fine Wine Asset Manager\nCult Wines Limited, the award-winning wine asset manager, today announces record performance figures for 2017 and continued international expansion with the opening of a new office in Shanghai.\nStrong financial performance\nCult Wines, which celebrates its tenth anniversary this year, has seen its annual revenues increase by 67% to £33.9m driven by growing demand for fine wine in the UK, Europe and particularly Asia, where sales increased by 123% in 2017. Asia now accounts for 33% of total revenues (up from 26% in 2016). Assets under management now stand at £65m and the firm expects total revenues to reach £55m for the forthcoming year. The firm’s client base has grown by 28% and it now manages private and trade portfolios across 71 countries.\nInvestors turning to fine wine to mitigate equities market correction\nCult Wines’ financial performance is supported by investment returns with the Cult Wine Investment Performance returning 10.3% over 2017, outperforming the Liv-ex recognised benchmark, which returned 5.7%1. During 2017 Cult Wines saw new clients choosing to diversify their portfolio by investing in fine wine to mitigate a potential correction in equities markets.\nGiven the growing importance of Asia, Cult Wines has opened an office in Shanghai to strengthen its Chinese presence, having established an office in Hong Kong in 2016. China is already the single biggest consumer of luxury goods globally with 29% of total spend across the whole Asia Pacific region and Cult Wines is seeing significant growth in rare and fine wine investment.\nTom Gearing, BBC The Apprentice (2012) finalist and Managing Director at Cult Wines, said, “Last year was a landmark for us that culminated in these robust figures, multiple award recognition, growth of our international activities and a strong platform for growth into 2018. Our new office in Shanghai will be followed by additional geographic expansion and further investment opportunities.”\nPhil Gearing, Chairman of Cult Wines adds, “To post these strong financial figures underlines the essence of what we do in taking a financial market approach to fine wine investment and delivering consistent and above average returns to our growing client base. Over the last 10 years we have succeeded in building a business that balances market leading fine wine expertise and knowledge with an asset management and technical perspective and approach. We would like to take this opportunity to thank our clients, partner agents and staff for helping us achieve this.”\nconcluded Patrick Thornton-Smith, Commercial Director at Cult Wines.\n(1) The Cult Wine Investment Performance is calculated from October 2009 by including all positions held by client by wine and vintage, individually entering the index rebased to 100 in the month of purchase and re-valued monthly using the Liv-ex Benchmark Market Price. The CW index increased 10.3% from Jan 1st – Dec 31st 2017 compared to a 5.7% gain in the Liv-ex 100 in 2017* (the industry’s leading benchmark).", "label": "No"}
{"text": "1 can blackeyed peas\n1 can hominy\n1 can whole kernel corn\n1 or 2 tomatoes, depending on size\n1 green pepper\n1/2 cup yellow onion\n4-6 green onions\n2 cloves garlic\n1/2 cup parsley or cilantro\n1/2 cup salsa\n1/2 cup salad vinegar\n1/4 cup olive oil\nRinse and drain peas, hominy and corn.\nDe-seed and chop the tomatoes, green pepper and jalapeno.\nChop the onions, mince the garlic.\nRough chop the parsley or cilantro.\nToss all except dressing until well mixed.\nStir in the salsa.\nBlend the vinegar with olive oil and pour over the mixture.\nLet stand several hours or overnight.\nServe with tortilla chips.\nIt's best served well chilled.", "label": "No"}
{"text": "You are here\nHistory of Whareroa Guardians Community Trust Inc\nThe history of Whareroa goes back a long way. Up until 1850 it was used by local Māori for horticulture, most likely for growing kūmara crops. There was also a pā situated on the flat land. In 1850 Alexander MacKay leased it as a farm and later purchased it. In 1941 it was passed to the Wellington Hospital Board as a likely site for a chest hospital.\nWith the onset of World War 2, the land was acquired for defence purposes. In 1942 the Public Works Department built Camp Mackay on the site for United States Marine Corps training and recreation. Six years later it was taken over by the Lands and Survey Department, which developed it as a recreation and farm education park for public use. By the 1980s, it was providing school trips and open days and had a number of public walking tracks. Management of the land was transferred to Landcorp in 1987, as part of the state owned enterprise restructure that saw Lands and Survey divided into the Department of Conservation and Landcorp. The farm was closed to the public.\nIn 2003 rumours emerged that Landcorp was planning to sell Whareroa Farm to developers for subdivision, a plan that the local community strongly opposed.\nSupported from many quarters, including the Kapiti Coast District Council, the community mounted a campaign to save the land from development. It was felt that the land, which had historical and intrinsic links to Queen Elizabeth Park, was a recreation ‘hub’ with huge tourist and recreation potential for the Kapiti Coast.\nIn 2005 the Guardians of Whareroa group was formed and extensive lobbying of the Government began. A protest song was recorded and the campaign became a vibrant one engaging the wider community. The campaign did not go unnoticed. The issue of the sale of public land became an election issue, and on 19 August 2005, the Government announced that it had decided to purchase the land from Landcorp for $4.5 million and transfer it to the Department of Conservation.\nThis was a time of great celebration. On 1 September 2005, the first public picnic at Whareroa, organised by the Guardians of Whareroa, drew a crowd of 300 people.\nSince then, the Whareroa Guardians Community Trust, using grants from the Ministry of the Environment and WWF-NZ Habitat Protection Fund, Tindall Foundation, has worked on substantial bush and stream restoration projects involving over 200 volunteers and 30,000 plants. This is ongoing and the community is invited to join in this activity.\nIn 2010 the Department of Conservation commenced the development of the reserve with parking, an information bay, tracks within the farm and picnic areas. They are working with the Kapiti Mountain Bike Club and horseriders as well as the Trust to develop appropriate recreational opportunities.\nIn March 2011 the Whareroa Guardians’ volunteers built a significant stone wall at the entrance.\nOn 30th April 2011 Whareroa Farm was opened for public use as a recreation reserve with a major celebration.\nThe Department of Conservation and the Trust are working together to develop this wonderful property into a first-class recreation and educational nature facility.", "label": "No"}
{"text": "Yellowstone is frequently referred to as a land of fire and ice, but to the casual summer observer this may seem only half true. Visiting in the winter, however, is like setting foot onto another planet.\nThe places that shape us, permeate our memories, and inform our passions are many and varied. What does it mean to call a place home? What does it mean to connect with a place? What makes a spot special?\nThe AmeriCorps members are rock stars in this community. Their arrival at the beginning of each season breathes new life into Coyote Canyon, and their passion and creativity throughout their terms of service add quality to the student experience here at TSS.", "label": "No"}
{"text": "Would you put a cash advance loans in your Direct present credit? Exactly what are the charges with lead present cash advance loans? In this post, we’re going to focus on firms that are selling cash loans against SSI, handicap, because national advantage investigations.\nLast, we respond to the most common questions concerning this matter.\nDefining Lead Specific Cash Advance Loans?\nThere are a few creditors that include payday advances that are geared towards national advantage readers, most notably Direct exhibit cardholders.\nDependent upon the bank, you could potentially submit an application for that loan either using the internet or even in person.\nTo try to get that loan you have to often submit your company name and private contact details, social protection amounts, time of birth, ID, job updates, and revenue particulars.\nJust what is an instant payday loan?\nA payday loan is normally a short-term, high-cost funding, usually, for $500 or much less, that is definitely typically because of on your following that pay check (or then national features pay check).\nSubject to a state rule, cash loans might be available through storefront paycheck lenders or on the internet.\nExpense of a quick payday loan\nNumerous state laws set a max amount for payday loan online fees including ten dollars to $30 for each and every one hundred dollars pilfered.\nA normal two-week payday loans with a $15 per one hundred dollars costs equates to an annual number fee (APR) of almost 400 per cent.\nIn contrast, APRs on credit card bills range from about 12 % to about 30 percent.\nThe chart the following from Intercept reveals exactly how big the rate of interest for payday advance loans tends to be according to your state.\nWas Direct Convey Cash Loan recommended?\nYou will need to tackle payday or cash advance payday loans with extreme caution.\nShould you do not comprehend the terms of the loan PREVENT reread the settlement and enquire problems.\nWhile cash loans is promoted as any as a type of financing, capable easily secure your into obligations.\nThats because payday advance loans or payday loans commonly feature quite high-interest rate.\nFAQs about Drive Convey Cash Advance Loans\nHere are the most commonly need questions linked to the lead Convey Cardless perks Access.\nCan I become a boost over at my handicap confirm?\nSure, in many instances, individuals which obtain societal Safeguards transfers will are eligible for a payday loan.\nSocial Safeguards qualifies to look for money, making all SSI people eligible for payday loans.\nThere are a few loan providers that give payday advances being directed at federal benefit individuals, contains drive exhibit cardholders.\nDependant upon the lender, it is possible to apply for a mortgage either on-line or even in person.\nShould you really need an online payday loan against your very own handicap consult? Thats an individual purchase.\nHowever, you should look into the money necessary for a payday loan as mentioned over.\nUnderstanding Drive Exhibit Funds Connection?\nUtilizing the lead exhibit financial availability program, lead specific cardholders may get easy access to financial using levels.\nYou can get the complete available balances on the drive Express credit up to $1,000 at any Walmart venue in the usa.\nThe cost is actually $1.50 per exchange. No extra Walmart fees apply.\nWhat exactly is the drive exhibit Emergency Cash system?\nThe lead specific crisis profit course lets you receive as much as $1,000 from the funds on your very own lead Express card profile without your very own credit at hand.\nYou could uncover your money at any MoneyGram place in the U.S., U.S. pure Destinations, or Puerto Rico.\nBy using the disaster money system, we dont must have your own debit credit together with you.\nFurthermore, the fee towards unexpected emergency finances application are both $8.50 for as much as $500 or $12.00 for up to $1,000.\nWhat is Drive Convey Cardless Perks Connection?\nThe lead specific Cardless advantage entry is yet another name for the lead specific Emergency finances system.", "label": "No"}
{"text": "After the successful National Games Berlin 2022, we as the local organizing committee took a little rest, but only to start all the more motivated into the preparations for the World Games. Kicking it off with a sportive team event: an inclusive triathlon.\nWorld Games team members, employees of Special Olympics Germany and Special Olympics athlete Marcel Eckhardt met on Saturday morning, 27 August, to master an inclusive triathlon together at Berlin Wannsee.\nThe fully motivated triathlon gang already met up at 8 o'clock in the morning. One or the other might still have been a bit sleepy, but even the last spirits were awakened during the joint warm-up with good music.\nBy a total of 6 relays consisting of three persons each, the three disciplines swimming, cycling and running were covered.\nAll teams successfully mastered the distances, loudly cheered each other on and, above all, experienced a happy day together – while drawing attention to inclusive sports and our movement!\nAt the end of the sporty team event, not only did everyone receive a medal, which they proudly accepted, but they also sat together with snacks and drinks.\nNow we go strengthened and motivated into the hot phase of preparations for the Special Olympics World Games Berlin 2023!", "label": "No"}
{"text": "Google has created a calendar where users can track what hobbies or activities were trending during lockdown in 2020. Google unveiled the platform on…\nFintech accelerator AlphaCode has reached over 1000 members in a single year.\nThe Rand Merchant Investment (RMI) initiative has seen eight member-to-member deals and invested R9-million into 11 various black-owned businesses through their partnership with Bank of America Merrill Lynch. AlphaCode has also invested in Merchant Capital, which provides alternative working capital for SMEs in SA.\n“The Rand Merchant Group has a history of partnering extraordinary entrepreneurs who have built disruptive, successful businesses such as RMB, Discovery and OUTsurance,” said senior investment executive at RMI, Dominique Collett.\nCompanies that joined AlphaCode cover various sectors of industry. These range from lending, payments and financial literacy to blockchain as well as robo-advising and data analytics.\nMany of the members already operate as successful tech businesses while others use AlphaCode’s networking and mentoring opportunities to successfully launch their businesses.\nAlphaCode has had a particularly successful year, signing on even more prominent members\n“To accelerate the kind of financial innovation that we envisaged we knew we needed two things. Firstly, to get the right people into the right room at the right time and secondly to apply growth capital to the best fintech ideas,” said Collett.\n“AlphaCode has brought us in touch with SA’s most promising fintech entrepreneurs. Our members have won South African and international awards, they have bravely launched new products and forged new partnerships,” she continued.\nSome of the AlphaCode members include Bankymoon, who’ve begun to consult to the SA Reserve Bank on blockchain technology. Others also include Peach Payments, an online payment solution; Livestock Wealth (the founder being recognised as one of Ventureburn’s top entrepreneurs under 40) and Merchant Capital.\n“AlphaCode has provided a great launch platform. It offers young companies a large networking web into the fintech world. Our experience and participation have allowed us to meet innovative companies and people to the benefit of our business,” said Fincheck’s co-founder Michael Bowren.", "label": "No"}
{"text": "Attachment as a Collective Resource: Attachment Networks During Middle Childhood in a Cameroonian Clan\n|Becke, Sophia Daphne\n|Attachment theory is commonly used to investigate children's psychosocial development. To demonstrate cultural variability and to advance the idea of attachment as a collective resource, we assessed children's attachment networks during middle childhood among the Nseh, a Cameroonian clan with distinct concepts of family and childhood. Using photo elicitation interviews, we used an exploratory approach to investigate the structural and functional composition of these networks and to generate a comprehensive overview. Participants were 11 children (six girls and five boys), aged 6 to 10 years. Children took photos of individuals who were important to them and with whom they felt safe, comfortable, and at ease. Then, in follow-up interviews they were asked to characterize their attachment figures on sociostructural dimensions and to elaborate how those individuals made them feel comfortable and safe. Transcripts of the interviews were coded using ethnographic strategies. Initial descriptive codes were analyzed concerning key terms, semantic relationships, and their context of meaning, before assigning higher level codes to generate distinct main categories of functionality. Children described attachment networks that were structurally adapted to concepts of social ties and interactional norms of the clan. Concerning their functionality, children differentiated between peers, responsible for overt emotional needs, and adults, providing nutritional care. We conclude that this pattern reflects sources of security and concepts of care of the distinct developmental environment. We discuss the importance of context-specific and comprehensive approaches to attachment, moving beyond Eurocentric monotropic concepts, with the goal of developing a complex understanding of childhood across ecocultural settings.\n|German National Academic Foundation; Association of the Friends and Supporters of the Goethe University Frankfurt; The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was funded by a scholarship of the German National Academic Foundation and further support from the Association of the Friends and Supporters of the Goethe University Frankfurt.\n|SAGE PUBLICATIONS INC\n|JOURNAL OF CROSS-CULTURAL PSYCHOLOGY\n|photo elicitation interviews\n|Attachment as a Collective Resource: Attachment Networks During Middle Childhood in a Cameroonian Clan\n|2455 TELLER RD, THOUSAND OAKS, CA 91320 USA\n|J. Cross-Cult. Psychol.\nchecked on Apr 17, 2024", "label": "No"}
{"text": "A Multicultural Chameleon; Actor's Experience Spawns Polyglot Cast of Characters\nPublished: October 9, 1999\n(Page 2 of 2)\nThey listened to Nirvana and Lynyrd Skynyrd. They went to the mall. They couldn't tell an Italian from a Puerto Rican. ''Here I was in North Carolina, and I couldn't even pass for white!'' said Mr. Hoch, who dropped out of college in less than two years, returned to New York and began writing his own material.\nIt is worth noting that the people at Stratosphere Entertainment, the distributor for ''Jails,'' the movie, describes Mr. Hoch's roots as in ''the projects in Brooklyn,'' which is the kind of market it is seeking for the film.\nIssues of authenticity are well understood by Mr. Hoch. ''It's not cool to live in the suburbs, ride your skateboard,'' Mr. Hoch says with equal parts irony and empathy. ''It's cool to be poor; it's cool to be in jail.''\nIt is hard not to notice white children today -- or the children of Pakistani immigrants, or Colombians -- mimicking black language and style, buying millions of dollars in rap music, lionizing the black ghetto, as they imagine it.\nOf course, that sort of impulse is not altogether new. Which is why when Norman Mailer saw ''Whiteboys'' recently, he wondered whether Mr. Hoch had read ''The White Negro,'' his own 1957 treatise about white hipsters schooled in black style. Mr. Hoch had not. But in ''Whiteboys,'' Mr. Mailer, now 76, recognized himself, a young man going to rent parties in Harlem. ''I'm not surprised it's happening again,'' he said.\nIn the improbable latter-day attempts at passing, Mr. Belcon, who wrote the ''Whiteboys'' screenplay with Mr. Hoch, says he sees a glimmer of hope. ''I think it's about not being complacent, not accepting what people tell you you're supposed to be,'' Mr. Belcon, now 29, said. ''It's a cross between rebellion and admiration.''\nMr. Hoch has turned those everyday acts of passing into his metier, literally trading caps, accents, gestures to conjure a gestalt of New York personalities of all shades. But it is precisely his yen to play characters who are not white that has opened him to scrutiny; is his performance, critics ask, a kind of minstrelsy?\nDael Orlandersmith, an actress who does one-woman shows, says although she knows that Mr. Hoch mines his characters from the world he grew up in, she is still troubled by the way white audiences react to his performances: ''Here's this white cat hanging out with black and Hispanic cats. Isn't that cool?'' Ms. Orlandersmith, who is black, says.\n''I think his intention is good, but I think people aren't listening to his intention,'' she says.\nMr. Hoch insists that his characters are the New Yorkers most familiar to him. The teen-ager who is shot and crippled by the police in ''Jails'' is based on a youth in Williamsburg. The distressed Jewish mother whose prejudices are challenged by her bohemian son in ''Some People'' is a melange, according to his mother, of herself and her Aunt Ida.\n''These ARE my people,'' Mr. Hoch says. ''Your people are a combination of ancestry and where you live -- your geography.\n''That community,'' he adds, ''is not the white community, it's not the Jamaican community, it's not the Puerto Rican community, it's not the black community. It's the community of all of us. I'll be the last one to say my community is the black community. I'll also be the last one to say Abner Louima and Anthony Baez are not my people.''\nPhotos: Danny Hoch, actor, comic and one-man show, at home in Williamsburg, Brooklyn. He sees hip-hop as a cultural glue. (Chester Higgins Jr./The New York Times); Mr. Hoch last year in his one-man show ''Jails, Hospitals and Hip-Hop.'' He assumes an un-Seinfeldian range of roles. (Paula Court)(pg. B1); From left, Danny Hoch, Eugene Byrd and Bonz Malone in the film ''Whiteboys.'' Mr. Hoch's character aspires to be a gangster rapper. (Fox Searchlight Pictures)(pg. B7)", "label": "No"}
{"text": "There's this mexican restaurant near me that makes the best tacos. tacos, like i've never tasted anywhere before. they say it's a california mexican restaurant and i don't really know what that means but the tacos are divine.\nthe ground beef they use is super greasy, so much so that it just seeps through the shell into the wax paper that they bring them out on. i can't detect any sort of spice in the meat either, which is strange. it's just a messy hard taco. i was wondering though, if anyone has any suggestions on how to get similar results with ground beef. whenever i make my taco meat, it comes out dry and without a lot of flavor and when i add cumin or the chili powder, it just ends up tasting fake. i'd really like to be able to make a good taco for cinco de mayo, so if anyone has any suggestions, i'd love to hear them.", "label": "No"}
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{"text": "more recipes like:\n“This is a no-nonsense recipe for corn on the cob. Perfect for when you run out of stove or grill space.”\nCelebrate Passover with Jewish main dishes, desserts, and traditional holiday foods.\nChoose your Easter dinner main dish from hams, savory lamb, and over 150 more recipes.\nDelicious recipes, party ideas, and cooking tips! Get a year of Allrecipes magazine for $7.99!\nRead our allrecipes.com blog", "label": "No"}
{"text": "Vestfrost ULT freezers VT78 / VT208 / VT308 / VT408 / VTS258\nThe VT low temperature freezers creates the possibility to maintain temperatures as low as -86°C. Supreme stability, reliability, user-friendliness and ease of cleaning make these freezers an ideal solution for laboratories and hospitals. Nature R refrigerant, cyclopentane insulation combined with recyclable materials make the freezers extremely eco-friendly.\n- User-friendly and maintenance-free\n- Battery backup for temperature display and alarm\n- Plug & Play\n- Contact For Remote Alarm\n- Natural refrigerant", "label": "No"}
{"text": "Absolut Spirits Co., part of Sweden's Vin & Sprit, the world's No. 6 spirits company, and Pernod Ricard USA, the domestic arm of Groupe Pernod Ricard, the world's fourth-largest liquor concern, will continue to coexist at TBWA, at least for now.\n\"There have been discussions, and so far it's not presented a problem,\" said Absolut President-CEO Carl Horton. \"Yes, they're both at TBWA. Yes, they both exist there, but there have been precautions and guidelines.\"\nPernod Ricard executives said they had no plans to change agencies, with some earlier saying the French-based company was satisfied the agency had erected sufficient firewalls. Absolut will continue at TBWA's New York office. Pernod Ricard will be serviced out of a separate New York office of G1 Worldwide, a joint venture between TBWA Worldwide and Japan's Hakuhodo, according to executives close to the situation.\nThe specter of conflict first arose last December with the dissolution of Seagram Spirits & Wine Co. following parent Vivendi Universal's decision to focus its portfolio on entertainment. That led to speculation of a review or shuffle because TBWA handled Absolut vodka-which Seagram had marketed in the U.S.- as well as several other Seagram brands that were acquired by Pernod Ricard, including Chivas Regal and Glenlivet.\nIt was thought TBWA, which turned Absolut and its bottle into an icon after landing the account in 1981, might part with Pernod Ricard, whose highest-profile brands prior to the Seagram deal had been Wild Turkey bourbon and Campari liqueur. Absolut last year received $31 million in measured media, while Pernod Ricard predecessor Austin Nichols & Co. laid out just $6.6 million, according to Taylor Nelson Sofres' CMR. Pernod's former Seagram brands received about $20 million.\nEven though the two liquor marketers compete for the same drinkers, the TBWA/Absolut/Pernod Ricard troika appears to be working because the marketers do not consider each other threats.\nAbsolut's biggest U.S. property is its vodka, while Pernod Ricard's only U.S. vodka is the considerably lower-brow Wodka Wyborowa. Last year, Polish vodka Wyborowa sold about 10,000 cases in the U.S., compared with Absolut's 4.7 million cases, according to spirits industry publication Impact.\nPernod Ricard's other primary agency is Publicis Groupe's Saatchi & Saatchi.\nIn January, Pernod Ricard consolidated its $30 million media planning and buying account at Aegis Group's Carat, New York. Much of Seagram's media work had been at Grey Global Group's MediaCom, which won Diageo's $150 million U.S. beer and spirits business in September (AA, Jan. 7).\ncontributing: rich thomaselli", "label": "No"}
{"text": "Job Title: Finance Intern\nReference: FIT 2016\nRecruiter: Stratostaff East Africa\nProfile Introduction: Our client, an International Company, dealing with the provision of solutions in energy, healthcare, transportation and finance is seeking to recruit a Finance Contractor based in Kenya.\nThe candidate should have a minimum of one year of experience and should have dealt with any form of financial software for a period of time.\nRole Summary: The Financial Contractor is in charge of the smooth running of all onsite accounting operations. Ensuring all financial statements are up to date.\nQualifications / Requirements\n- One year experience in a Financial Institution.\n- Should be conversant with any accounting software.\n- CPA is an added advantage.\n- Should be an under graduate with a Bachelor’s degree from any recognized University.\n- Reconcile, Analyze and identify disconnects for all dimensions i.e. Currencies, Account, Cost\n- Centre, Ref ID, IME/ILE, Project Codes and Book type\n- Prepare correcting journal entries using the standard HJE format ensuring that all required dimensions are completed and balanced\n- Liaise with GL Leaders to have correcting journals (HJE) reviewed and uploaded into the business ERP\n- Assist in preparation of ledger tie-outs between business ERPs; identify and propose corrective action for any disconnects between the ledgers\n- Review the Trial balance for completeness at all dimension level once the HJE has been posted\n- Liaise with the Stat Leaders to reconcile the US GAAP and Statutory balances and Prepare adjusting journals (HJE/ADI) for upload into business ERP\n- Reconcile the FA register to Physical Inventory and GL Ledger\n- Check and confirm correct FA accounts are in use as per FA classification and company guidelines\n- Check and confirm that FA are capitalized at the correct entered/original currencies\n- Prepare correcting journal entries for GL adjustment, using the standard HJE format ensuring that the correct accounts, and all required dimensions are completed and balanced\n- Liaise with GL Leaders to review and upload the correcting journals into business ERP\n- Reconcile the AR sub-ledger balances to the General Ledger to ensure that they both tie-out\n- Reconcile collection reports from GE CARS to the AR sub-ledger balance\n- Propose adjusting journals (HJE) to correct any disconnects between Sub ledger, GL and\n- Collection reports\n- Assist in the I2C team in applying open receipts to invoices\n- Financial Software / PC Proficiency\n- Planning and organizing\n- Attention to detail\n- Communication skills\n- Knowledge of generally accepted accounting and bookkeeping principles and procedures\n- Must be willing to comply with pre-employment screening, which may include but not limited to, drug testing, reference verification and background check.\n- Must be 18 years of age or older.\nHow to Apply\nIf you are qualified and up to the challenge send your Resume and Cover Letter to [email protected] by 15th April 2016", "label": "No"}
{"text": "- This event has passed.\nALL Multi-Session Course: Square Dancing in Three Easy Steps (All Puns Intended)\nApril 27, 2017 @ 6:30 pm - 8:00 pm\nSquare Dancing in Three Easy Steps (All Puns Intended)\nWith Ann Fallon\nDate: Three sessions on Thursdays, April 27, May 4, 11\nLocation: Talbot Senior Center, 400 Brookletts Avenue, Easton\nRegistration is required to Allison Speight at firstname.lastname@example.org or 410-745-4941\nWhether you’re new to square dancing or a seasoned professional, this is the event for you. No previous dance experience is necessary. We’ll explore traditional American folk dances such as squares, circles, and longways set dances in the spirit of the “barn dance,” where neighbors would come together to enjoy music, dance, food, and good company. Everyone is welcome. All dances are taught and called with no fancy footwork required. We will use recorded music for the first two dances and a live band for the third dance party!\nBring a partner or come by yourself; it works either way. There will be plenty of dance partners at this party. Frequent partner changes are encouraged.\nWear smooth-soled shoes so you can glide across the floor. And if you want, don your jeans, stetson, and boots if you have them. Bring whatever you wish to drink and eat.\nMembers $30 | Non-Members $45", "label": "No"}
{"text": "Hi, y’all! My name is Sarah, and I am 29 years old. Two years ago, at 4’10” and 185 lbs, I made the decision to change my life through health and fitness. I was sick of the back pain, knee pain, chronic heartburn and acid reflux, and everything else that came with being obese. My goal was to be at least around 115 lbs but I didn’t have enough time to go to the gym enough this is why I decided to try Garcinia Cambogia XT And Natural Cleanse Plus.\nWhat Is Garcinia Cambogia XT?\nGarcinia Cambogia XT is a appetite suppressant that prevent fat from being made and moves towards glycogen which is an energy source that helps burn more fat. If you have problems with emotional eating this will help you stop these craves for food. Also if you are looking for a supplement that will help you continue to lose weight after your workout sessions this will do the job. You can see all the benefits of the Garcinia Cambogia fruit Here- What Is Garcinia Cambogia.\nWhat Is Natural Cleanse Plus?\nDose Garcinia Cambogia XT Really work?\nAlot of people have been asking me if Garcinia Cambogia XT And Natural Cleanse Plus really work. The answer to this is yes but to get the full potential of them I highly recommend you to do some kind of exercise with that. If you don’t have a workout or diet plan you must know that by ordering Garcinia Cambogia XT you will receive some extra bonuses that will sort this out for you. You can see the Bonuses on the picture below-\nDo I need to take Garcinia Cambogia XT and Natural Cleanse Plus together or I can order only one?\nYou can always order only one at a time but for faster results I would recommend you to order both at a time. On top of that I’m not sure how long their trial offer will last so if you don’t wanna pay the 89$ price per bottle I recommend you to get them now on their official website below-\nGarcinia Cambogia XT And Natural Cleanse Plus Before and after pictures.\nYou must take pictures of you instead of relying on a scale to have a accurate measurement of your progress, especially if you are doing weight lifting exercises. By replacing fat with muscles you will think that you are not losing weight when actually you are. It’s just that your muscles can become heavier than your grease. Taking pictures every month will be more accurate than your scale. You can see my before and after pictures below-\nThis is me after 1 year of workout and combining Garcinia Cambogia XT and Natural Cleanse Plus. I was 185 lbs when I started my journey and I’ve hit a plateau at 120 lbs. I just got started doing some crossfit to be able to hit my ideal weight. When I first got started I was losing around 10lbs per month until I hit my plateau. You can see another picture of me before and after below-\nAs you can see these supplements really work but you will need to follow the workout tips that you will get with the bonuses you’ll get when you order Garcinia Cambogia XT.\nIf I can do it anybody can do it. All you need is the will and the perseverance.\nYou also really need to be careful of what you’re eating and when you are eating it.If you have anymore questions feel free to comment in the comment box below I’ll be happy to help you out. Note that I’m not getting paid to write this review about Garcinia Cambogia XT And Natural Cleanse Plus, it’s just that I like to share with people that are like minded. If you have any workout tips or anything about the subject post them here so that other people can see them. Remember that their risk free trial offer will not last forever if you you don’t wanna pay 80 something dollars just to try them order yours today on their official website below", "label": "No"}
{"text": "For Mike Tarburton:\n>From my verandah in Ipswich Qld at 6.30 am today 4 January 2007, 2 WTNs low\nLast year 22 November 2006, at Miller's Road north of Gatton, Qld, GPS\n27.28.54, 152.19.03, from about 8.30 am to about 9.30, approx 40 WTNs flying\nlow over the trees and sometimes below canopy height.\nThen near the gate to the Lockyer Forest Reserve (same general area north of\nGatton), GPS 27.29.36, 152.18.33, about 10.00 am, 3 overhead low but higher\nthan the others.\n28 December 2006, same site at Miller's Road, about 2 pm, at least 6 WTNs very\nlow sometimes below canopy height.\n2 Cintra Street\n07 3282 9151\nTo unsubscribe from this mailing list,\nsend the message:\n(in the body of the message, with no Subject line)", "label": "No"}
{"text": "We celebrate a string of palindromic dates - 1/20/21 to 1/29/21 - with music written in palindromic form. Music by Martha Horst, Ben Johnston, Frank J. Oteri, Andrew Norman, Ted Hearne, Joseph Schwantner and Bela Bartok.\nDuring the LA Philharmonic’s 2018/19 season, they commissioned 50 new works from artists including Louis Andriessen, Unsuk Chin, Philip Glass, and Steve Reich, just to name a few. Composer and curator of the first of the LA Phil’s new music series, entitled Green Umbrella, Andrew Norman talks about the Southern Californian composers that he’s presenting. … Continue reading #266 Green Umbrella\nFounding cellist of Eighth Blackbird, Nick Photinos, joins us in WFMT’s Levin Studio in Chicago to play pieces from his first solo album. Nick worked with an exciting array of diverse composers on the album including David T. Little, Angélica Négrón, Florent Ghys, Andrew Norman and Bryce Dessner. Hosted by Seth BousteadProduced by Sarah … Continue reading #248 Nick Photinos\nWith recent commissions and performances from the L.A. Philharmonic, Boston Modern Orchestra Project and the New York Philharmonic, in addition to his work with celebrated collective Sleeping Giant, Andrew Norman has emerged as a major figure in today’s classical music world. He stops by the studio to chat with Seth about music, life and everything. Hosted by Seth … Continue reading #189 Andrew Norman\nOnce a year the American Academy in Rome holds a competition, honoring 15 emerging artists as well as 15 scholars from the US with the so-called Rome Prize. The winners are invited to the Academy, where they can thrive on the presence of cultural heritage as well as the exchange with the fellows from other … Continue reading #73 Rome Prize", "label": "No"}
{"text": "Oligomeric ricinoleic acid preparation promoted by an efficient and recoverable Bronsted acidic ionic liquid.\nABSTRACT: Raw material from biomass and green preparation processes are the two key features for the development of green products. As a bio-lubricant in metalworking fluids, estolides of ricinoleic acid are considered as the promising substitute to mineral oil with a favorable viscosity and viscosity index. Thus, an efficient and sustainable synthesis protocol is urgently needed to make the product really green. In this work, an environment-friendly Brønsted acidic ionic liquid (IL) 1-butanesulfonic acid diazabicyclo[5.4.0]undec-7-ene dihydrogen phosphate ([HSO3-BDBU]H2PO4) was developed as the efficient catalyst for the production of oligomeric ricinoleic acid from ricinoleic acid under solvent-free conditions. The reaction parameters containing reaction temperature, vacuum degree, amount of catalyst and reaction time were optimized and it was found that the reaction under the conditions of 190 °C and 50 kPa with 15 wt % of the [HSO3-BDBU]H2PO4 related to ricinoleic acid can afford a qualified product with an acid value of 51 mg KOH/g (which corresponds to the oligomerization degree of 4) after 6 h. Furthermore, the acid value of the product can be adjusted by regulating the reaction time, implying this protocol can serve as a versatile method to prepare the products with different oligomerization degree and different applications. The other merit of this protocol is the facile product separation by stratification and decantation ascribed to the immiscibility of the product and catalyst at room temperature. It is also worth mentioning that the IL catalyst can be used at least for five cycles with high catalytic activity. As a result, the protocol based on the IL catalyst, i.e. [HSO3-BDBU]H2PO4 shows great potential in industrial production of oligomeric ricinoleic acid from ricinoleic acid.\nProject description:Without using any toxic or hazardous reagent, ligand, acid, transition metal catalyst, additives/promoters and organic solvent, green Knoevenagel condensation and tandem Knoevenagel-Michael reactions have been successfully carried out by using chickpea leaf exudates as a naturally sourced Bronsted acid type bio-catalyst. The reaction proceeds in neat chickpea leaf exudates at room temperature in aqueous conditions in very short reaction times, and therefore, it is an evergreen and environmentally sound alternative to the existing protocols for benzopyran synthesis. In comparison to the conventional methods, this synthetic pathway complies with several key requirements of green chemistry principles such as the utilization of biodegradable catalyst obtained from renewable feedstock, auxiliary aqueous conditions, along with waste prevention. The same protocol was also extended to the synthesis of 2H-xanthene-1,8-diones by condensation of aromatic aldehydes with dimedone achieving excellent yields. Thus, the reported protocol offers an attractive option because of its ecological safety, environmental acceptance, sustainability, low-cost straightforward work-up procedure and with excellent values of green chemistry metrics as compared with other reported methods.\nProject description:1. Ricinoleic acid is shown to be synthesized in the immature castor bean seed only after 3-4 weeks from the time of fertilization. 2. Synthesis occurs both in the isolated embryo and the endosperm. 3. Linoleic acid does not act as precursor of ricinoleic acid in the isolated bean embryo. 4. Oleic acid is shown to be the direct precursor of ricinoleic acid. 5. The reaction does not use molecular oxygen. This suggests that ricinoleic acid is not a precursor of linoleic acid.\nProject description:SmCl3 (20 mol%) has been used as an efficient catalyst for reaction between aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione at 120°C to give 1,8-dioxo-octahydroxanthene derivatives in high yield. The same reaction in water, at room temperature gave only the open chain analogue of 1,8-dioxo-octahydroxanthene. Use of eco-friendly green Lewis acid, readily available catalyst and easy isolation of the product makes this a convenient method for the synthesis of either of the products.\nProject description:Different inhibition types of the saturation kinetics involving a synthesized model complex, [Bu4N]3[MoVIO2(mnt)2] (E) (where mnt2- = 1,2-dicyanoethylenedithiolate), and HSO3- as the substrate (S) by structurally similar anions SO4(2-), H2PO4- and H2PO3- have been shown for the first time in relevance to the reductive half reaction of the native enzyme sulphite oxidase. SO4(2-) acts as a competitive inhibitor. The mixed-type non-competitive inhibition by H2PO4- and the sigmoidal-type inhibition by H2PO3- are explained by a diamond-configuration random-order model. This involves a random binding sequence of the substrate and the inhibitor, and forms, in addition to two binary complexes [enzyme-substrate (ES) and enzyme-inhibitor (EI)], one enzyme-substrate-inhibitor-type ternary complex (ESI) by participation of at least one more binding site in addition to the catalytic site. This is possible in the present case only by co-ordination enhancement of molybdenum in E. This co-ordination expansion is brought about by nucleophilic attack of the substrate or the inhibitor at the molybdenum, forming a hepta-coordinated binary complex with the generation of an oxoanionic functional site, called the allosteric site. Analysis of the experimental data suggests that the inhibition by H2PO4- is due to the mechanism following either equilibrium conditions or a combination of steady-state and equilibrium conditions. With H2PO3-, the inhibition is due to the mechanism following the steady-state conditions. It is also shown that the ternary complex involving the enzyme, substrate and H2PO4- or H2PO3- is productive, but at a lower rate than that of the enzyme-substrate binary complex. Mixed-type inhibition with H2PO4- is actually of the type called \"partially mixed competitive and non-competitive' as the inhibitor binds both to the catalytic site and to the allosteric site. The sigmoidal-type inhibition by H2PO3- is similar to heterotropic allosteric effect of mixed V,K type with the distinction, however, that the significance of co-operativity in this case is of kinetic importance only.\nProject description:Herein, a practical and mild method for the deoxygenation of a wide range of benzylic aldehydes and ketones is described, which utilizes heterogeneous Pd/C as the catalyst together with the green hydride source, polymethylhydrosiloxane. The developed catalytic protocol is scalable and robust, as exemplified by the deoxygenation of ethyl vanillin, which was performed on a 30?mmol scale in an open-to-air setup using only 0.085?mol?% Pd/C catalyst to furnish the corresponding deoxygenated product in 93?% yield within 3?hours at room temperature. Furthermore, the Pd/C catalyst was shown to be recyclable up to 6 times without any observable decrease in efficiency and it exhibited low metal leaching under the reaction conditions.\nProject description:Stable, catalytically active palladium nanoparticles of various average diameters (1.9-7.4 nm) have been synthesized and characterized by X-ray diffraction, spectroscopy, and microscopy techniques to demonstrate remarkable size-dependent and renewed catalytic activity toward the Suzuki-Miyaura coupling reaction in green protocol. The catalytic activity is found to depend on the amount of the reducing agent, stabilizer-precursor ratio, solvent composition, and aryl halides used. The product obtained by this reaction is characterized by 1H NMR, 13C NMR, and IR spectroscopy analyses. A newly developed kinetic equation illustrates that while the catalyst particles of the lowest dimension are gradually exposed to the reactants and hence activated due to partial removal of capping polymer from the catalyst surface, others are deactivated due to agglomeration during the progress of the reaction, as conformed by the microscopic profiles of the used and unused catalysts.\nProject description:We describe the synthesis of silver loaded on zirconia and its use as an efficient catalyst for a one-pot three-component reaction to synthesize 11 indenopyrimidine derivatives, of which 7 are new compounds. The procedure involves substituted benzaldehydes, indane-1,3-dione, and guanidinium hydrochloride, with ethanol as solvent. The proposed green protocol at room temperature is simple and efficient, giving excellent yields (90?96%) in short reaction times (<30 min). The protocol works well according to the green chemistry principles with respect to high atom economy, no need for column separation, and reusability of the catalyst, which are attractive features. XRD, TEM, SEM, and BET analysis were used to characterize the catalyst materials.\nProject description:The optimization and kinetics of the ring-opening reaction of an epoxidized biodiesel (epoxidized rapeseed oil methyl ester) (EBD) with 2-ethyl hexanol (2-EH) were studied. The determined optimum conditions were 4:1 2-EH/oil molar ratio, 90 °C, 18 h, and 7 wt % of Amberlyst D001 (dry) catalyst; the product's oxirane oxygen content was 0.081% with 38.32 mm²/s viscosity at 40 °C. The catalyst retained its high catalytic power after recycling five times. Furthermore, the determined non-catalyzed activation energy was 76 kJ·mol-1 and 54 kJ·mol-1 with the D001 resin catalyst. The product's chemical structure was investigated through FT-IR and ¹H NMR. The viscosity, flash point, pour point, and anti-wear properties of the product were improved compared with those of epoxidized biodiesel.\nProject description:A highly efficient and recyclable catalyst, cerium-immobilized silicotungstic acid nanoparticle-impregnated zirconia (Ce@STANPs/ZrO2), has been synthesized. The catalytic activity of Ce@STANPs/ZrO2 was investigated for the first time in multicomponent synthesis of isatin-based imidazoles under microwave irradiation in water. Ce@STANPs/ZrO2 was used for C=O bond activation in overall reaction to synthesize isatin-based imidazoles. The structure of catalyst was confirmed by characterization techniques, such as Fourier transform infrared (FTIR), scanning electron microscopy (SEM)/energy dispersive X-ray, elemental mapping, transmission electron microscopy, ?-potential and diffraction light scattering, X-ray diffraction (XRD), thermogravimetric analysis, temperature-programmed desorption-NH3, electron paramagnetic resonance (EPR), and inductively coupled plasma atomic emission spectroscopy (ICP-AES) analyses. The recovered catalyst was found to be efficient up to seventh cycle and was confirmed by FTIR, SEM, XRD, EPR, and ICP-AES analyses. The advantages of the present protocol are recyclability of catalyst, green reaction conditions, excellent yield (94%) of the products, shorter reaction time period (5-7 min), and clean reaction profile.\nProject description:The optimum conditions to produce palm fatty acid distillate (PFAD)-derived-methyl esters via esterification have been demonstrated with the aid of the response surface methodology (RSM) with central composite rotatable design in the presence of heterogeneous acid catalyst. The effect of four reaction variables, reaction time (30-110 min), reaction temperature (30-70°C), catalyst concentration (1-3 wt.%) and methanol : PFAD molar ratio (3 : 1-11 : 1), were investigated. The reaction time had the most influence on the yield response, while the interaction between the reaction time and the catalyst concentration, with an F-value of 95.61, contributed the most to the esterification reaction. The model had an R 2-value of 0.9855, suggesting a fit model, which gave a maximum yield of 95%. The fuel properties of produced PFAD methyl ester were appraised based on the acid value, iodine value, cloud and pour points, flash point, kinematic viscosity, density, ash and water contents and were compared with biodiesel EN 14214 and ASTM D-6751 standard limits. The PFAD methyl ester was further blended with petro-diesel from B0, B3, B5, B10, B20 and B100, on a volumetric basis. The blends were characterized by TGA, DTG and FTIR. With an acid value of 0.42 (mg KOH g-1), iodine value of 63 (g.I2/100 g), kinematic viscosity of 4.31 (mm2 s-1), the PFAD methyl ester has shown good fuel potential, as all of its fuel properties were within the permissible international standards for biodiesel.", "label": "No"}
{"text": "Please use this identifier to cite or link to this item:\n|ON THE INFLUENCE OF DIFFUSION STABILIZATION IN OLDROYD-B FLUID FLOW SIMULATIONS\n|Finite Element Method\n|In Proceedings Topical Problems of Fluid Mechanics 2020\n|This work presents some numerical tests of finite element solution of incompressible Oldroyd-B fluid flows. The effect of numerical stabilization using arti cial stress diffusion is investigated\nin detail. The limits of Weissenberg number We for which is possible to obtain the numerical solution were studied depending on the Reynolds number Re and the diffusion parameter.\nSeries of numerical tests was performed for steady two-dimensional Oldroyd-B fluid flow in corrugated channel (tube). The numerical results clearly proved the advantage (higher attainable We) of stabilized numerical method over the classical formulation without the arti ficial stress diffusion.\n|ISSN 2336-5781 (Print)\n|Appears in Collections:\n|CIMA - Artigos em Livros de Actas/Proceedings\nItems in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.", "label": "No"}
{"text": "The Supreme Court of the United States has expressly recognized that, under the Due Process Clause of Fourteenth Amendment and the Compulsory Process and Confrontation Clauses of the Sixth Amendment, a criminal defendant must be given “a meaningful opportunity to present a complete defense” -i.e., a right to make a full defense, and tell his or her story, by presenting relevant and probative evidence that supports his or her case. See, e.g. California v. Trombetta, 467 U.S. 479, 485 (1984). See also Crane, 476 U,S, at 689\nRule 405(b) of Alabama Rules of Evidence states: “In cases in which character or a trait of character of a person is an essential element of a charge, claim, or defense, proof may also be made of specific instances of that person’s conduct.” The Alabama Court of Criminal Appeals has previously ruled that Rule 405(b) “authorizes the admission of testimony concerning specific instances of a victim’s violent conduct in a case where the victim’s violent character is essential to a defendant’s claim of self-defense.” Clancy v. State, 886 So. 2d 166, 169 (Ala. Crim. App. 2003)\nPrior specific acts actually are proper evidence of the reasonableness of a defendant’s actions and his “state-of-mind” in a self-defense case. Williams v. State, 938 So. 2d 440, 448 (Ala. Crim. App. 2005)\nThe Alabama Court of Criminal Appeals has even found that evidence of a general reputation for violence, blood-thirstiness or dangerousness, much less specific acts toward the accused, is admissible as having probative value on elements of the doctrine of self- defense. “Evidence of this type is also admissible for the purpose of showing a reasonable apprehension of immediately pending danger which would justify the accused in striking more quickly, under the circumstances prevailing at the time of the homicide.” Brooks v. State, 263 Ala. 386, 389, 82 So. 2d 553, 555 (1955) Alabama law even recognizes the right of one who has received mere threats to “act more promptly and on slighter overt act or demonstration than it would in the absence of such proof”. Raines v. State, 455 So. 2d 967, 971 (Ala. Crim. App. 1984)\nAlso, evidence of “physical and emotional injuries received by [a Defendant] in the prior difficulties” was relevant and probative on the issue of state-of-mind “by reason of continuing pain from injuries suffered by him.” Dickerson v. State, 360 So. 2d 1045, 1053 (Ala. Crim. App. 1978)\nHowever, Alabama also fully allows expert testimony of battered syndrome.\n“[E]xpert testimony on Battered Woman Syndrone can be admitted to assist the jury in understanding the syndrome, and also to help the jury determine whether the defendant had an honest belief that she was in imminent danger, as that determination related to a claim of self-defense.\nHarrington v. State, 858 So. 2d 278, 294 (Ala. Crim. App. 2002) Alabama courts have actually elaborated extensively on the policy behind these principles of admissibility of testimony, both lay and expert, on the effects of being a battered woman. This Court in Bonner quoted, at length, State v. Kelly, a New Jersey case:\nWhat the expert could state was that defendant had the battered-woman’s syndrome, and could explain that syndrome in detail, relating its characteristics to defendant, but only to enable the jury better to determine the honesty and reasonableness of defendant’s belief. Depending on its content, the expert’s testimony might also enable the jury to find that the battered wife, because of the prior beatings, numerous beatings, as often as once a week, for seven years, from the day they were married to the day he died, is particularly able to predict accurately the likely extent of violence in any attack on her. That conclusion could significantly affect the jury’s evaluation of the reasonableness of defendant’s fear for her life.\nAccordingly, lay and expert testimony regarding the history of abuse and the resulting behavioral responses are admissible and relevant in self-defense cases to provide the jury with a proper understanding, unencumbered by prevailing myths concerning battered women, of the circumstances surrounding the reasonableness of the defendant’s actions. Alabama case law makes such evidence admissible and relevant to the state-of-mind necessary for the defense of self-defense.\nMany states have actually enacted statutes to specifically allow such evidence. This issue is so important that the Alabama Court of Criminal Appeals made an unusual request of the Legislature.\n“In light of these and similar tragic events, a reevaluation of Alabama’s body of law surrounding self-defense and battered spouse syndrome is necessary. It has become increasingly clear that leaving an abusive relationship may not, in fact, mean that the victim’s safety is no longer threatened. As our own cases show, domestic violence often escalates to deadly levels. . .The difficult situation presented to this Court in [battered woman cases] can be avoided in future cases if the Alabama Legislature seizes the opportunity to address this important issue, as the legislatures in other jurisdictions have done. We encourage the Legislature to address the existing body of law on self-defense as it relates to battered spouse syndrome.“\nSo far, the Legislature has not taken up this call.", "label": "No"}
{"text": "Online CAD Viewer\nSpinFire Web allows users to investigate 3D CAD parts and metadata without an expensive CAD license. SpinFire Web securely accesses 3D data via a web-browser and keeps the CAD file local to your server, enabling collaboration yet maintaining control of the CAD file. Enable internal or external personnel to access CAD data via a browser without downloading the CAD or running software locally.\nCentro automatically generate Bill of Materials from CAD assemblies to visually compare within BOM Manager. BOM manager provides side-by-side comparisons and ensures concurrency between eBOM/mBOM, CAD versions to avoid producing from the wrong BOM or file version. Visually compare Bills of Material structures side-by-side and be alerted to any differences or concurrency issues.\nSecure Check-in and Check-out for all file types\nGain greater control of your product information by defining user access rights and permissions. Check in/ check out protects your data and prevents confusion or information loss when teams collaborate. Check-in and check-out applies to all resources and any file type, not just CAD. Full revision history is available for file recovery and to prevent data loss through users overwriting.\nSearch and find CAD parts and Engineering metadata\nRapidly locate product data, save time and eliminate duplicate part creation with Centro Search. Centro’s Search technology provides a rich user experience eliminating the need to navigate an often chaotic folder structure. Create a condition based search criteria using attributes and find your file based on associated metadata that defines what the file is, rather than guessing where it is.\nAutomatic File Synchronization\nKeep Product Data in Sync and ensure everyone is working to the latest file version. Centro Pipeline Manager automates file publishing and manages the import of data through information pipelines. Sync your files to Centro and overcome the challenge of sharing engineering type data; provide information workers with visibility and access to valuable product data.\nActify’s enterprise solutions are designed solely for discrete manufacturers, to complement other enterprise applications, enable self-service reporting, plus focused on the key functionality needed for managing product data across the enterprise. Contact us to arrange a product demonstrationArrange a Demo", "label": "No"}
{"text": "After protracted transfer negotiations, Belgium international Charles De Keteleare has moved from Club Brugge to Italian giants AC Milan, becoming the Jupiler Pro League's most expensive export in the process.\nCharles De Keteleare, who was named Belgian Young Player of the Year in 2021, has switched one league champion for another, joining last season's Serie A winners AC Milan from Jupiler Pro League champion Club Brugge.\nAC Milan had to fend off interest from English side Leeds United and undertake lengthy negotiations with Club Brugge, who were set on making De Ketelaere most expensive outgoing transfer in the history of the Jupiler Pro League.\n- Union Saint-Gilloise dream continues as they beat Rangers 2-0 in first leg\n- The average pro footballer makes €266,000 per annum in Belgium\nIn the end, they got their wish as the €35 million transfer fee they received for him, trumps the €27 million French side Lille payed to get Canadian striker Jonathan David out of Gent in 2020.\nDe Keteleare's transfer is also the most expensive fee payed for a Belgian player coming out of Belgium's top league, surpassing the €26 Million Rennes payed to get Jeremy Doku, the former Anderlecht attacker, to come to France.", "label": "No"}
{"text": "The fish tech space is growing, and fast. It was just a few years back that industry folks and nonprofits alike were trying to get their heads around what end-to-end traceability might look like and which technologies might be used to facilitate it. Since then, we’ve seen technologies such as blockchain, electronic monitoring, and machine learning make a splash in the seafood and ocean conservation spaces. With the exploding number of companies and initiatives, it can be hard to keep up.\nThis is the first in a series of blog posts about fisheries system intermediaries.", "label": "No"}
{"text": "Dalila Argaez Wendlandt was unanimously confirmed to serve as an associate justice on the Supreme Judicial Court where she will be the first Latina to sit on the bench in the high court’s history.\nThe Governor’s Council voted 7-0 on Wednesday to approve Wendlandt’s nomination. She will replace Associate Justice Barbara Lenk, who retires next week.\nWendlandt, a first-generation Colombian who earned a master’s degree in engineering from MIT before entering the legal profession, is expected to bring a unique perspective to the high court. Councilor Terrence Kennedy touted her as a “fantastic nominee.”\nBaker called the 51-year-old justice a “highly intelligent, accomplished jurist” in a statement. Before joining the Appeals Court in 2017, she was a partner in the intellectual property litigation group at Ropes & Gray LLP.\nCouncilor Marilyn Petitto Devaney said Wendlandt has an extensive list of published writings and was once appointed to propose changes to Massachusetts patent laws.\n“Her legal experience even extended to being co-counsel on a death penalty matter in another state, so I am very pleased to make that motion to appoint Judge Wendlandt to the Supreme Judicial Court,” Devaney said. “We have great members up there, every one of them.”\nWendlandt’s confirmation continues a rapid-fire process of historic appointments that will expand the diversity of the SJC. Wendlandt is Gov. Charlie Baker’s sixth appointment to the high court — his second this month. Baker made three SJC nominations in November, spurred by the untimely death of the late Chief Justice Ralph Gants whose heart attack in September sent shock waves through the state’s legal community.\nThe Governor’s Council confirmed Chief Justice Kimberly Budd last week to be the first Black woman to lead the high court. Baker’s third nominee, Boston Municipal Court Judge Serge Georges Jr., is a first-generation Haitian American.\nWith Wendlandt and Georges’ confirmations, it will make for the most diverse court in its 328-year history. It also cements Baker’s legacy, who will have nominated each of its seven members.\n“We face, as you all know, a global pandemic and a call to end decades — no, centuries — of racial injustice and I don’t pretend to have all the answers, but I offer a consistent, rational and compassionate perspective,” she said during three hours of hearings last week.\nIt’s a privilege awarded to just one other governor in the state’s history: John Hancock, who established the high court while serving as the commonwealth’s first-ever governor.\nIt’s a legacy that could far outlast the Baker administration’s tenure in the corner office.\n“I just want to say how honored I am to be part of your work and be part of what I feel and I think all of you feel is historic in our commonwealth,” Lt. Gov. Karyn Polito said following Wendlandt’s confirmation at Wednesday’s meeting.", "label": "No"}
{"text": "Go to the main menu\nSkip to content\nGo to bottom\nREFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS\n> Journal Vol & Issue\nKorean Journal of Remote Sensing\nJournal Basic Information\nJournal DOI :\nThe Korean Society of Remote Sensing\nEditor in Chief :\nVolume & Issues\nVolume 23, Issue 6 - Dec 2007\nVolume 23, Issue 5 - Oct 2007\nVolume 23, Issue 4 - Aug 2007\nVolume 23, Issue 3 - Jun 2007\nVolume 23, Issue 2 - Apr 2007\nVolume 23, Issue 1 - Feb 2007\nSelecting the target year\nObject-oriented Classification and QuickBird Multi-spectral Imagery in Forest Density Mapping\nJayakumar, S. ; Ramachandran, A. ; Lee, Jung-Bin ; Heo, Joon ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 153~160\nForest cover density studies using high resolution satellite data and object oriented classification are limited in India. This article focuses on the potential use of QuickBird satellite data and object oriented classification in forest density mapping. In this study, the high-resolution satellite data was classified based on NDVI/pixel based and object oriented classification methods and results were compared. The QuickBird satellite data was found to be suitable in forest density mapping. Object oriented classification was superior than the NDVI/pixel based classification. The Object oriented classification method classified all the density classes of forest (dense, open, degraded and bare soil) with higher producer and user accuracies and with more kappa statistics value compared to pixel based method. The overall classification accuracy and Kappa statistics values of the object oriented classification were 83.33% and 0.77 respectively, which were higher than the pixel based classification (68%, 0.56 respectively). According to the Z statistics, the results of these two classifications were significantly different at 95% confidence level.\nModeling of Suspended Solids and Sea Surface Salinity in Hong Kong using Aqua/MODIS Satellite Images\nWong, Man-Sing ; Lee, Kwon-Ho ; Kim, Young-Joon ; Nichol, Janet Elizabeth ; Li, Zhangqing ; Emerson, Nick ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 161~169\nA study was conducted in the Hong Kong with the aim of deriving an algorithm for the retrieval of suspended sediment (SS) and sea surface salinity (SSS) concentrations from Aqua/MODIS level 1B reflectance data with 250m and 500m spatial resolutions. 'In-situ' measurements of SS and SSS were also compared with coincident MODIS spectral reflectance measurements over the ocean surface. This is the first study of SSS modeling in Southeast Asia using earth observation satellite images. Three analysis techniques such as multiple regression, linear regression, and principal component analysis (PCA) were performed on the MODIS data and the 'in-situ' measurement datasets of the SS and SSS. Correlation coefficients by each analysis method shows that the best correlation results are multiple regression from the 500m spatial resolution MODIS images,\n= 0.82 for SS and\n= 0.81 for SSS. The Root Mean Square Error (RMSE) between satellite and 'in-situ' data are 0.92mg/L for SS and 1.63psu for SSS, respectively. These suggest that 500m spatial resolution MODIS data are suitable for water quality modeling in the study area. Furthermore, the application of these models to MODIS images of the Hong Kong and Pearl River Delta (PRO) Region are able to accurately reproduce the spatial distribution map of the high turbidity with realistic SS concentrations.\nDesign and Implementation of Hyperspectral Image Analysis Tool: HYVIEW\nHuan, Nguyen van ; Kim, Ha-Kil ; Kim, Sun-Hwa ; Lee, Kyu-Sung ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 171~179\nHyperspectral images have shown a great potential for the applications in resource management, agriculture, mineral exploration and environmental monitoring. However, due to the large volume of data, processing of hyperspectral images faces some difficulties. This paper introduces the development of an image processing tool (HYVIEW) that is particularly designed for handling hyperspectral image data. Current version of HYVIEW is dealing with efficient algorithms for displaying hyperspectral images, selecting bands to create color composites, and atmospheric correction. Three band-selection schemes for producing color composites are available based on three most popular indexes of OIF, SI and CI. HYVIEW can effectively demonstrate the differences in the results of the three schemes. For the atmospheric correction, HYVIEW utilizes a pre-calculated LUT by which the complex process of correcting atmospheric effects can be performed fast and efficiently.\nComparison of Three Land Cover Classification Algorithms -ISODATA, SMA, and SOM - for the Monitoring of North Korea with MODIS Multi-temporal Data\nKim, Do-Hyung ; Jeong, Seung-Gyu ; Park, Chong-Hwa ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 181~188\nThe objective of this research was to investigate the optimal land cover classification algorithm for the monitoring of North Korea with MODIS multi-temporal data based on monthly phenological characteristics. Three frequently used land cover classification algorithms, ISODATA1), SMA2), and SOM3) were employed for this study; the land cover categories were forest, grass, agricultural, wetland, barren, built-up, and water body. The outcomes of the study can be summarized as follows. First, the overall classification accuracy of ISODATA, SMA, and SOM was 69.03%, 64.28%, and 73.57%, respectively. Second, ISODATA and SMA resulted in a higher classification accuracy of forest and agricultural categories, but SOM performed better for the built-up area, bare soil, grassland, and water. A possible explanation for this difference would be related to the difference of sensitivity against the vegetation activity. This would be related to the capability of SOM to express all of their values without any loss of data by maintaining the topology between pixels of primitive data after classification, while ISODATA and SMA retain limited amount of data after normalization process. Third, we can conclude that SOM is the best algorithm for monitoring the land cover change of North Korea.\nImproving the Quality of Filtered Lidar Data by Local Operations\nSeo, Su-Young ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 189~198\nIntroduction of lidar technology have contributed to a wide range of applications in generating quality surface models. Accordingly, because of the importance of terrain surface models in mapping applications, rigorous studies have been performed to extract ground points from a lidar data point cloud. Although most filters have been shown abilities to extract ground points with their parameters tuned, however, most experiments revealed that there are certain limitations in optimizing filter parameters and the correction of remaining misclassified points is not straightforward. In this study, therefore, a method to improve the quality of filtered lidar data is proposed, which exploits neighboring surface properties arising between immediate neighbors. The method comprises a sequence of procedures which can reduce commission and omission errors. Commission errors occurring in low-rise objects are reduced by utilizing morphological operations. On the other hand, omission errors are reduced by adding missing ground points around step edges. Experimental results show that the qualities of filtered data can be improved considerably by the proposed method.\nBuilding Extraction from Lidar Data and Aerial Imagery using Domain Knowledge about Building Structures\nSeo, Su-Young ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 199~209\nTraditionally, aerial images have been used as main sources for compiling topographic maps. In recent years, lidar data has been exploited as another type of mapping data. Regarding their performances, aerial imagery has the ability to delineate object boundaries but omits much of these boundaries during feature extraction. Lidar provides direct information about heights of object surfaces but have limitations with respect to boundary localization. Considering the characteristics of the sensors, this paper proposes an approach to extracting buildings from lidar and aerial imagery, which is based on the complementary characteristics of optical and range sensors. For detecting building regions, relationships among elevation contours are represented into directional graphs and searched for the contours corresponding to external boundaries of buildings. For generating building models, a wing model is proposed to assemble roof surface patches into a complete building model. Then, building models are projected and checked with features in aerial images. Experimental results show that the proposed approach provides an efficient and accurate way to extract building models.\nA Semi-automated Method to Extract 3D Building Structure\nJavzandulam, Tsend-Ayush ; Kim, Tae-Jung ; Kim, Kyung-Ok ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 211~219\nBuilding extraction is one of the essential issues for 3D city modelling. In recent years, high-resolution satellite imagery has become widely available and it brings new methodology for urban mapping. In this paper, we have developed a semi-automatic algorithm to determine building heights from monoscopic high-resolution satellite data. The algorithm is based on the analysis of the projected shadow and actual shadow of a building. Once two roof comer points are measured manually, the algorithm detects (rectangular) roof boundary automatically. Then it estimates a building height automatically by projecting building shadow onto the image for a given building height, counting overlapping pixels between the projected shadow and actual shadow, and finding the height that maximizes the number of overlapping pixels. Once the height and roof boundary are available, the footprint and a 3D wireframe model of a building can be determined. The proposed algorithm is tested with IKONOS images over Deajeon city and the result is compared with the building height determined by stereo analysis. The accuracy of building height extraction is examined using standard error of estimate.\nAn Assessment of Urbanization Using Historic Satellite Photography: Columbus Metropolitan Area, Ohio, 1965\nKim, Kee-Tae ; Kim, Jung-Hwan ; Jayakumar, S. ; Sohn, Hong-Gyoo ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 221~227\nWe present an analysis of urban development and growth with reconnaissance satellite photographs of Columbus metropolitan area acquired by the Corona program in 1965. A two-dimensional polynomial linear transformation was used to rectify the photos against United State Geological Survey (USGS) Large-scale Digital Line Graph (DLG) data georeferenced to Universal Transverse Mercator (UTM) coordinates. The boundaries of the Columbus metropolitan area were extracted from the rectified Corona image mosaic using a Bayesian approach to image segmentation. The inferred 1965 urban boundaries were compared with 1976 USGS Land Use and Land Cover (LULC) data and boundaries derived from 1988 and 1994 Landsat TM images. The urban area in and around Columbus approximately doubled from 1965 to 1994 (\n) along with population growth from 1960 to 1998 (\n). Most of the urban expansion results from development of residential units.\nImplementation of Satellite Imagery Information System for Korean Meteorological Administration\nChang, Eun-Mi ; Park, Jong-Suh ; Suh, Ae-Sook ;\nKorean Journal of Remote Sensing, volume 23, issue 3, 2007, Pages 229~236\nScattered satellite images were collected and converted from TDF to HDF as a standard format. We reviewed all the metadata on the images domestic and abroad and set up the metadata for the meteorological satellite images and naming rules in KMA. The satellite information search system that meteorological satellite images were in service with metadata for public and academic fields was implemented for quick search and download. This system will facilitate satellite images for various academic purposes beyond KMA and management functions of the system make routine workflow to manage satellite images in an ease and standardized way.", "label": "No"}
{"text": "The Benefits of Reloading Ammunition\nThere are several reasons shooters reload their own ammunition.\n- Costs – Reloading ammunition saves money. The major cost of ammunition is typically brass casings, which are used to hold everything together. Depending upon the ammunition type, it can be less expensive to reload casings than purchasing new bullets. This is especially true for .44-caliber ammunition. Casings are generally filled with primers, powder and bullets. Reloading ammunition is a practical solution for ammunition shortages, especially those that are hitting the .380 and .22lr markets.\n- Accuracy – Each specific firearm’s ammunition, based on the make and model, can be customized according to profile, construction, hardness and weight. All of these factors contribute to weapons’ accuracies. Different primers ignite at various rates, with some being cooler or hotter and others burning faster or longer. To boost accuracy, there are two major factors to consider when reloading ammunition.\n- Minimize component variations between cartridges, which includes powder and bullets.\n- Tailor reloading options to the dimensions of the firearm.\n- Fun – Most gun enthusiasts enjoy reloading ammunition. This process helps improve accuracy, teaches people more about their guns and how they work. Reloading ammunition isn’t time consuming, but people can develop this craft over time, learning new skills, tricks and methods. People who want to learn to reload their ammunition should have clean work areas, which makes this process much easier. Detailed notes are excellent references, allowing shooters to hone their reloading skills over time, discovering what improves or negatively affects accuracy. Shooters who reload their ammunition report greater satisfaction when using their weapons, feeling as though they’re more a part of the production process.\n- Decisions – Reloading ammunition isn’t for everyone. Generally it requires patience, attention to detail, extra time and a more advanced mechanical aptitude. This is also a great skill to have, especially when ammunition shortages strike or prices skyrocket. While some supplies are more difficult to find during shortages, such as presses, dies, primers, powder and bullets, it’s advisable to stock up on these necessary supplies year-round.\nJumping Targets offers a range of steel shooting targets. These targets are perfect for pistols and rifles, allowing shooters to test their reloaded ammunition for the ultimate accuracy. Whether it’s moving targets, a shooting gong or a dueling tree, these types of targets are designed to withstand repeated shooting.\nMade using the highest quality steel, these AR 500 targets don’t include clamps, brackets or bolts. These additions are generally weak points for targets, which is why Jumping Targets has created a design to eliminate these potential safety issues. Their targets are also designed to ricochet bullets at 20-degree angles, making them safe for shooters and bystanders alike.\nLeave a comment\nPlease note, comments must be approved before they are published", "label": "No"}
{"text": "The book will teleport in a pattern to every bench in the room. You have to run to each bench and complete the pattern. There is a timer and we found that if you just run on foot you never make it in time and the puzzle will reset. So mount up.\nOnce you complete the pattern the book will appear on the altar in front of the named mob in the room. That is the book you can read. It will stay there for about a minute before it resets so we had one person kill the mob while the other read the book. It is a long cast bar to read it so if you get interrupted a lot it will fail.\nThe currency gained is also needed for puzzle access.\nFYI, when you get the achievement for reading the book you will also get an \"item\" (I forget exactly what, since it has been awhile since I did this). This item can be used as \"currency\" to pay Omi the puzzle mistress, in Tempest bay canals for access to do one of the SL zone puzzles.\nIf you want to do this puzzle you will need 3 of these items, along with an artifact set completion prize for access to it. This means that you will have to read the book 3 times for 3 items of the needed currency.\nI didn't see this anywhere else, so I figured I'd post it for those newer players who are trying to get the achievement, or the Blob of Ectoplasm for the puzzle. Here is the sequence of benches that the Spooky Book jumps though. Being mounted definitely helps, though I have completed it on foot with a 15% speed buff and Insoles.", "label": "No"}
{"text": "I am receiving the following error when doing a subsequent deployment through doctl:\nerrors validating app spec; first error in field \"envs.0.value\": secret env value must not be encrypted before app is created\nThis is the command:\ndoctl apps create --upsert --spec app-spec.yml --wait --verbose\nHere is the relevant section of the app-spec.yml file:\nenvs: - key: DISCORD_BOT_TOKEN scope: RUN_AND_BUILD_TIME type: SECRET value: <REDACTED>\nI have tried multiple approaches (wondering if I did something wrong), and I am getting the error no matter what.\nI have read the documentation and community questions, and it seems that I am doing this correctly. e.g. https://www.digitalocean.com/community/questions/how-to-use-environment-values-of-type-secret-on-following-submissions\nAs you make updates to your app spec, if you don’t intend to change those encrypted values, then you should just submit with the in-place encrypted values unchanged.\nWhat is the correct approach to this? If there is an issue with the DOAP, is there a temporary workaround?\nThis textbox defaults to using Markdown to format your answer.\nYou can type !ref in this text area to quickly search our full set of tutorials, documentation & marketplace offerings and insert the link!\nThese answers are provided by our Community. If you find them useful, show some love by clicking the heart. If you run into issues leave a comment, or add your own answer to help others.", "label": "No"}
{"text": "Saturday, November 3, 2018\n10:00 AM - 2:00 PM\nFreedom Lake Park, 9990 46th St N, Pinellas Park, FL 33782\nOur reunion has a new name….GRRMF GoldenFest! The focus continues to be on fun, education and has two locations and dates to pick from (or attend both!) to accommodate our wonderful volunteers and adopters from coast to coast.\nEach location will feature special events and share the same wonderful opportunities for meeting our special GRRMF volunteers and adopters for networking and fun with your goldens!\nHere are the current events planned.\nPresenters / information available:\nTherapy information/west coast opportunity\nIt takes a Village – transportation and application/HV team speakers\nRescue Q&A with board members\nDog Sports information – fun for you and your dog\nOnline golden goods shopping opportunities\n2019 GRRMF Calendars for sale!\nSnacks will be provided. Please plan to bring a picnic lunch for your family.\nDog Friendly Hotel (6 miles from Freedom Lake Park)\nLa Quinta 7500 US Hwy 19 N, Pinellas Park, FL 33781\nI want to be a GoldenFest sponsor to help with costs so all funds raised go to helping goldens!\nIf you can’t make our 2018 Fall GoldenFest, here is the link for our 2019 Spring GoldenFest on March 2, 2019 in St. Cloud, FL", "label": "No"}
{"text": "FlexiCash is a facility offered to ICICI Bank Salary Account customers, whereby they can avail of a line of credit/ overdraft facility to meet unplanned or recurring expenses. It is designed to protect ICICI Bank Salary Account customers from missing their Equated Monthly Instalments (EMIs) or cheque bounces due to insufficient funds by providing short-term instant credit. Customers can easily avail of this facility by initiating their application online.\n|Pay only for what you use||Pay interest on the amount you use and for the period you use it for|\n|Flexible Repayment||Flexibility to clear the outstanding limit at your convenience, only the interest due to be paid every month|\n|Digital process for pre-approved customers||Avail of facility instantly by applying online with no documentation|\n|Auto sweep-in facility||Reduced interest burden due to the auto sweep facility from the Salary Account to the overdraft account|\n|Auto Renewal||Automated process of renewal of overdraft limit|\n|Pre-closure facility||Repay the amount whenever you want without any pre-closure charges|\n- Processing fee: Starting at Rs 1,999 + Goods and Services Tax (GST)\n- Renewal fee: Flat Rs 1,999 + GST\n- ROI: Between 12% and 14% per year\nFor Example: If you have a FlexiCash limit of Rs 1,00,000 with ROI of 12.20% and you use Rs 10,000 for an urgent expense, you will have Rs 90,000 left for other purposes. If you repay Rs 10,000 after 15 days and have not used any more of the FlexiCash funds, your interest payable will be Rs 50.14.\nTrusted Plans to secure your family\nDesigned to fulfil your different needs in every stage of life\nFulfil your dreams with ICICI Bank Education Loans\nAttractive Rate of Interest starting from 11.25% p.a\nNever leave your dreams hanging!\nGet a Personal Loan now with minimum documentation.", "label": "No"}
{"text": "The Internet of Things is here and the market is in the making. These devices are able to collect and transmit data via the Internet, contributing to our big data world. Here are some fact of IoT and we can see that the IoT is here to stay and grow.\nThe IoT is only going to grow and devices that could be connected to the Internet will be connected to the Internet. Can you imagine the tremendous potential and limitless opportunities this brings for business and society?", "label": "No"}
{"text": "Giving Naked Consents Some Weight, TTAB Reverses 2(d) Refusal of \"BUHLER & Design\"\nCan you name two places where naked consents are consequential? Nudist colonies and the TTAB. Applicant Buhler Technologies GmbH trumped a PTO Section 2(d) refusal by submitting naked consents from the owners of the two registrations cited by the Examining Attorney. Although Applicant conceded that the involved marks are essentially identical, the Board bought Applicant's argument that the goods of the parties are not related, and it gave \"some weight\" to the letters of consent in dubiously finding no likelihood of confusion. In re Buhler Technologies GmbH, Serial No. 79034792 (February 12, 2009) [not precedential].\nApplicant sought to register the mark first shown above (upper left) for various industrial goods and services in classes 7, 11, and 35. The PTO refused registration in light of four existing registrations owned by two companies, two of the registrations being for the word BUHLER in standard character form, and two for the word-and design marks show above right and bottom, all for various industrial goods and services. [The listings of the goods and services occupy about seven pages of the 21-page decision].\nThe two owners of the registrations provided letters of consent stating little more than that they \"hereby consent to the registration and use of the trademark 'Buhler'\" Applicant argued that these naked consents were entitled to \"some weight\" and, when coupled with the differences in goods and services, compelled a finding of no likelihood of confusion.\nThe Board noted that the consent letters lacked information regarding the \"underlying facts which led the parties to conclude that confusion is not likely,\" and contained no restrictions on use of the marks in order to avoid confusion. Moreover, the subject application is based \"solely on treaty rights and not on use in commerce,\" and so \"there is neither evidence of use nor any real basis for the affected parties to determine that, based upon prior experience, confusion is unlikely to occur.\"\nNonetheless, the Board concluded that the letters of consent \"are entitled to some probative value\": \"Specifically, we may infer from the fact that consent was given by both registrants that owners of the cited registrations do not believe confusion is likely.\"\nAs noted above, Applicant conceded that its mark is \"essentially identical\" to the cited marks. The Board not surprising found that the marks, when viewed in their entireties, are \"highly similar\" in appearance, sound, and connotation, and convey \"highly similar\" commercial impressions.\nAs to the strength of the marks, the Board vaguely found that in light of the existence of the cited registrations, the two registrants \"have contributed to the weakening of their marks such that they are entitled only to a somewhat narrowed scope of protection that is less than that to which a stronger mark may be entitled.\"\nFinally, turning to the goods, the Board noted the Examining Attorney's position that the various goods involved are \"broadly identified.\" However, according to the Board:\napplicant’s goods are all used in the fields of filtering, analyzing, distributing and monitoring fluids and gases. Registrants’ good are used in the fields of food and waste processing, air cleaning and conditioning, manufacturing, motors, engines and electrical devices used with such motors. As identified, both applicant’s and registrants’ goods are used for specific purposes that are not clearly related or encompassed by one another.\n[TTABlog note: Although Applicant's identification of goods includes some restrictions as to field of use, many of the goods in the cited registrations have no use restrictions. For example, Applicant's \"air filters for air conditioning units for use in connection with fluid-technical systems as well as systems for analysis of gases and liquids\" would seem to be either encompassed by or related to one Registrant's \"filters and air cleaners for industrial use\" and \"filtering systems and equipment, namely, bag filters, dust collectors, and dust separators\" and to the other Registrant's \"air conditioning fans; parts of air conditioning installations, namely fans.\"]\nScoffing at the \"mere conclusory statement\" of the Examining Attorney regarding the relatedness of the goods, the Board saw the PTO's likelihood of confusion claim as \"amounting to only a speculative, theoretical possibility.\"\nBased \"primarily\" on the dissimilarity between the goods and services, and giving \"some weight\" to the letter of consent, the Board found that the PTO had not met its burden to demonstrate a likelihood of confusion. And so it reversed the refusal to register.\nTTABlog comment: Is there any doubt that the Board could have found the goods (at least) related if it wanted to? Why give these naked consents any weight? I am baffled about that.\nText Copyright John L. Welch 2009.", "label": "No"}
{"text": "View Press Releases\nOrbita and Isabel Healthcare improve provider websites, patient experience\nOrbita and Isabel Healthcare Partner to Deliver Advanced ‘Find Care’ Search and\nSymptom Triage to Streamline Patient Access\nIntegrated functionality improves the patient experience with provider websites and the digital front door\nAnn Arbor, MI and Boston, MA – March 14, 2023 – Orbita, a leading provider of intelligent virtual assistants and workflow automation for healthcare, has partnered with Isabel Healthcare, a global company that delivers clinical reasoning tools for providers and a Symptom Checker/Triage for patients. Isabel’s Symptom Checker/Triage utilizes every-day language to help patients access appropriate care with the right urgency.\nToday, 70% of patients use digital tools when searching for providers, with 38% specifically visiting a provider’s website before scheduling care. However, patients often don’t know what to look for or how to focus their search, much less whether their current symptoms can be assessed at a next-day primary care visit or virtual visit – or more immediately at urgent care or the emergency room.\nThe Orbita Blaze “find care” solution, leveraging Isabel’s sophisticated triage algorithms, guides patients to an appropriate care setting by eliciting important information through a brief dialog. A smart virtual assistant poses questions in a conversational manner – asking about the patient’s location or insurer, for instance, and the severity of their symptoms – and then accurately and efficiently suggests next steps.\n“Like Isabel, Orbita prioritizes the patient experience,” said Isabel Healthcare CEO Don Bauman. “We are each contributing innovative technology to help providers achieve success on their digital-first journey. Our focus will continue to be on empathy and ensuring a consumer-friendly experience, as well as delivering accurate and relevant information to patients.”\n“Isabel shares Orbita’s commitment to meet patients 'where they are' so they can quickly and easily find information to make better decisions about their healthcare,” said Orbita CEO Patty Riskind. “With Orbita and Isabel combining forces, we bring the best symptom checker and best conversational virtual assistant together. Providers today are striving to do more with less, and our solutions allow for a better patient experience and reduced administrative burden on staff.\nABOUT ISABEL HEALTHCARE\nIsabel Healthcare Inc. was founded in 2000 by Jason Maude and is named after Maude’s daughter who almost died after a potentially fatal illness was not recognized. With its unique AI, the curated machine learning engine has been tuned and refined over 20 years. Isabel Healthcare is the global leader in providing tools to support both clinicians and patients in making decisions about diagnosis and where to seek care. Connect with us at http://www.isabelhealthcare.com, or 734-332-0612.\nOrbita is the connective tissue between providers and patients, to make navigating healthcare easier. We partner with healthcare organizations to implement smart virtual assistants, powered by conversational AI, that engage patients across web, text and voice channels. Our solutions – which meet critical privacy and security standards – help providers improve operational efficiency by automating workflows as they face the challenges of labor shortages, while also capturing revenue generated by routine, chronic and preventative care. Visit Orbita.ai.", "label": "No"}
{"text": "Best of 2018: DM Contributors Share Their Favorite Dance Moments of the Year\nDance Magazine editors and writers chose their favorite dance happenings of the year. Here are the moves, moments and makers that grabbed us:\nMost Heartbreaking History Lesson: THEM\nIshmael Houston-Jones (left) and dancers in THEM. Photo by Rachel Papo, courtesy Blake Zidell & Associates\nOriginally performed in 1986 at the height of the AIDS epidemic, THEM was revived this year at Performance Space New York just as our collective memory of the crisis veers dangerously close to fading. Created by choreographer Ishmael Houston-Jones, composer Chris Cochrane and writer Dennis Cooper, the piece is a brutal, vulnerable, haunting exploration of gay sexuality and the horrors that AIDS inflicted on the artistic community. The cast—a youthful group, mainly queer men of color—appropriately reinterpreted the improvisation-based choreography for a time when so much has changed, and yet so much hasn't. —Lauren Wingenroth, assistant editor\nThe Feminist Art We All Needed: The People Movers' Glass\nThe People Movers in Glass. Photo by Chelsea Robin Lee, courtesy Ladenheim\nWhat happens to a community forced to live under a glass ceiling? Glass, a film and performance project from Kate Ladenheim and The People Movers, handled heavy, heady concepts—like internalized misogyny and the patriarchal paradigm—in a way that was as artfully, entertainingly composed as it was intellectually stimulating. The four performers painted the audience's nails, preened in pantsuits and pushed each other's buttons—and showed off seriously smooth contemporary chops. —Courtney Escoyne, assistant editor\nBoldest Reinterpretation of a Story Ballet: Dada Masilo's Giselle\nDada Masilo's Giselle isn't pretty: The protagonist's death is disturbing, not romantic; the Wilis are frighteningly vengeful, not delicate or pitiful. A black South African choreographer, Masilo reveals the violence behind the beloved plot. When Giselle (danced by Masilo herself) is betrayed, beaten and sexually assaulted in front of fellow villagers, they mock her, blaming her for being foolish enough to let it happen—and reminding us how survivors have been treated since long before the rise of #MeToo. —Jennifer Stahl, editor in chief\nMost Creative Placemaking: Laura Gutierrez's Center Aisle Blues\nLaura Gutierrez in Center Aisle Blues. Photo by Dabfoto Creative Services, courtesy University of Houston Cynthia Woods Mitchell Center for the Arts\nLaura Gutierrez wanted to address her Houston Tejano heritage. Where better to do that than a Fiesta Mart, her go-to place growing up for everything from piñatas to quinceañera dresses? For Center Aisle Blues, Gutierrez spent weeks getting to know the staff and scouting her path through the store, finding its nooks and crannies. Her vocabulary ranged from sleek, linear movement to elaborate ways of connecting to the aisles. She fully owned the idea of dancing in the middle of a supermarket. The piece ended with her standing on her car in the Fiesta parking lot dressed in a sparkly fringed jacket, facing a city still recovering post-hurricane like a beacon of hope. —Nancy Wozny, contributor\nBest Gender-Bending Tap Dance: Caleb Teicher's Great Heights\nCaleb Teicher in Great Heights. Photo by ADG Photography, courtesy American Tap Dance Foundation\nHe's got style. He's got speed. And he's got chutzpah. This we know. But had we ever seen him dance in short shorts and high-heeled tap shoes? At American Tap Dance Foundation's Rhythm in Motion showcase, Caleb Teicher blew us away with his gender-bending solo Great Heights. His legs slapped, stomped and jabbed at the floor before he pounced on top of a bar stool. Then he kicked and tapped up a storm on that high perch. —Wendy Perron, editor at large\nMost Creative Use of Props: Mean Girls\nWho knew plastic lunch trays could stop a Broadway show? In Mean Girls, Casey Nicholaw trades tap shoes for trays to create percussive effects akin to classic song-and-dance numbers. The cafeteria-based \"Where Do You Belong?\" is a tongue-in-cheek breakout song, and it's deliciously over-the-top. —Madeline Schrock, managing editor\nMost Dynamic Performance: Dorothée Gilbert in La Fille mal gardée\nDorothée Gilbert in La Fille mal gardée. Photo by Francette Levieux, courtesy POB\nAs Lise in Sir Frederick Ashton's La Fille mal gardée, Paris Opéra Ballet étoile Dorothée Gilbert possessed mischief and charm that had the audience laughing out loud. From her seamless attitude promenade (supported only by ribbons) to her sharp footwork and even sharper comedic timing, Gilbert's performance was both a technical and an artistic dream. —Marissa DeSantis, style & beauty editor\nBiggest Boost to Ballet: San Francisco Ballet's Unbound Festival\nWith 12 world premieres from the likes of Justin Peck, Annabelle Lopez Ochoa and Alonzo King, San Francisco Ballet's Unbound Festival was a 17-day smorgasbord of dance. But it was so much more: Principal dancers revealed new sides of their artistry, featured roles transformed corps members into overnight stars and wildly imaginative works like Arthur Pita's Björk Ballet got everyone talking. At each intermission, the War Memorial Opera House lobby echoed with impassioned debates about what worked, what didn't and what was unlike anything seen before on the SFB stage. Unbound gave ballet, and audiences, a thrilling boost of adrenaline. —Claudia Bauer, contributor\nBest Breakthrough: Lauren Lovette in Alexei Ratmansky's Namouna\nLauren Lovette and Taylor Stanley in Namouna. Photo by Paul Kolnik, courtesy NYCB\nEvery so often, a performance seems to reveal the essence of a dancer. Lauren Lovette has always been a vivid performer. But during her debut in Alexei Ratmansky's fantastical, comic Namouna, a Grand Divertissement, the New York City Ballet principal infused her dancing with an attack and a lack of inhibition that felt new. \"I adapted the role to her, lifted the passés and made the battements bigger so she felt she could be big onstage,\" Ratmansky says of their collaboration. That push seems to have unleashed something in her. Channeling her already distinctive personality through the eccentricities of the role, she was more present than she's ever been. —Marina Harss, contributor\nMost Promising Debut Season: Terminus Modern Ballet Theatre\nIn four world-premiere works, Terminus Modern Ballet Theatre's inaugural season in Atlanta offered up dance that was technically pristine and highly entertaining. Braving torrential spring showers, Tara Lee's The Vertical closed the season outdoors with a playful and heartfelt look at aging. Whether out in the community or in a traditional theater, the five founding members of the company, all former Atlanta Ballet dancers, have shown that they know what it takes to put on a memorable show. —Candice Thompson, contributor\nMost Inventive Dance Play: The Beast in the Jungle\nSusan Stroman could have spent the rest of her days after The Producers just directing and choreographing in a similar, stupendously successful vein. But she went off-Broadway instead, and this year outdid herself with The Beast in the Jungle, at the Vineyard Theatre. Enlisting the extraordinary talents of Irina Dvorovenko and Tony Yazbeck, using multiple dance vocabularies, and going to a 1903 Henry James story for material, she put together what she calls a \"dance play,\" and it was altogether enthralling. John Kander's waltz-inspired score ran the gamut of emotions, and her choreography did too—from a swooningly romantic pas de deux to a wrenching, heartbreaking solo, with a fantastic, multiheaded imaginary beast in between. —Sylviane Gold, contributor\nMost Delightfully Unexpected Trend: Contemporary Dance in Music Videos\nThis year, Florence Welch and Akram Khan worked together on \"Big God,\" by Florence + The Machine; Emma Portner created movement for Maggie Rogers' \"fallingwater\"; and Sidi Larbi Cherkaoui choreographed \"APESHIT,\" by Beyoncé and Jay-Z. High-profile music artists hiring contemporary choreographers seemed to be the trend of 2018—even for music not traditionally considered \"dancy.\" These collaborations gave contemporary dance a bigger platform, and showed what it can bring to any style of music. —Kelsey Grills, audience engagement editor\nFor decades the name Alicia Alonso has been virtually synonymous with Ballet Nacional de Cuba, the company she co-founded in Havana in 1948. Alonso died on October 17, just shy of what would have been her 99th birthday. In recent years, she had stepped back from day-to-day decision-making in the company. As if preparing for the future, in January, the company's leading ballerina, 42-year-old Viengsay Valdés, was named deputy director, a job that seems to encompass most of the responsibilities of a traditional director. Now, presumably, she will step into her new role as director of the company. Her debut as curator of the repertory comes in November, when the troupe will perform three mixed bills selected by her at the Gran Teatro de la Habana Alicia Alonso. The following has been translated from a conversation conducted in Spanish, Valdés' native tongue.\n\"The show must go on\" may be a platitude we use to get through everything from costume malfunctions to stormy moods. But when it came to overcoming a literal hurricane, Houston Ballet was buoyed by this mantra to go from devastated to dancing in a matter of weeks—with the help of Harlequin Floors, Houston Ballet's longstanding partner who sprang into action to build new floors in record time.\nNew York City Ballet principal Sara Mearns wasn't sure she was strong enough. A ballerina who has danced many demanding full-length and contemporary roles, she was about to push herself physically more than she thought was possible.\n\"I said, 'I can't. My body won't,' \" she says. \"He told me, 'Yes, it will.' \"\nShe wasn't working with a ballet coach, but with personal trainer Joel Prouty, who was asking her to do squats with a heavier barbell than she'd ever used.\nHer Dying Swan was as fragile as her Juliet was rebellious; her Odile, scheming, her Swanilda, insouciant. Her Belle was joyous, and her Carmen, both brooding and full-blooded. But there was one role in particular that prompted dance critic Arnold Haskell to ask, \"How do you interpret Giselle when you are Giselle?\"\nAt eight, Alicia Alonso took her first ballet class on a stage in her native Cuba, wearing street clothes. Fifteen years later, put in for an ailing Alicia Markova in a performance of Giselle with Ballet Theatre, she staked her claim to that title role.\nAlonso received recognition throughout the world for her flawless technique and her ability to become one with the characters she danced, even after she became nearly blind. After a career in New York, she and her then husband Fernando Alonso established the Cuban National Ballet and the Cuban National Ballet School, both of which grew into major international dance powerhouses and beloved institutions in their home country. On October 17, the company announced that, after leading the company for a remarkable 71 years, Alonso died from cardiovascular disease at the age of 98.", "label": "No"}
{"text": "MULTIFAMILY BRIDGE LOANS | DIRECT PRIVATE LENDERS FOR APARTMENT REHAB LOANS\nFAST AND RELIABLE SMALL APARTMENT LOANS | 5 DEVICE MULTI FAMILY https://titleloansusa.info FINANCING | LONG-TERM PERMANENT FINANCING LOAN | BRIDGE LOANS AQUIRE | RENOVATE | REFINANCE\nAQUIRE. RENOVATE. REFINANCE\nTidal Loans focuses on rate, simpleness, and above the rest, transparency.\nThe needs are understood by us of investors through the entire investment lifecycle, from purchase to renovation to stabilization. Our program consist of minimal advance payment for multifamily apartment estate that is real in search of apartment rehab loans. We would not have a DSCR requirement of our multifamily rehab loans.\nWe provide as much as 85per cent LTC, 90% CLTV to not ever meet or exceed 70% of this after stabilized value. This exclusive loan system for apartment structures provides the flexibility to our borrowers and leverage to benefit on Multifamily & Mixed-Use investment possibilities that will need rehab or low occupancy. We additionally give you a 30-year loan system for investors seeking to cashflow their house long haul.\nThe MULTI FAMILY REHAB LOANS ARE SUPERB:\n- Once the home is distressed and needs rehab.\n- You to close quickly when you are working with a seller or wholesaler who needs.\nOnce the home is vacant, perhaps perhaps not stabilized, leased up, or producing any cashflow.\nTIDAL LOANS APARTMENT LOANS PROGRAM OVERVIEW\nAPARTMENT REHAB LOANS | BR\n- LOAN AMOUNT-$250K-$20M\n- TERMS-12-24 MONTHS\n- LTC- AS MUCH AS 85% OF EXPENSE\n- LTV- 70% OF ARV\n- CLTV- 90%\n- CASH OUT REFI- 65% LTV\n- AMORTIZATION- INTEREST ONLY\n- DSCR- NO REQUIREMENT\n- Property Types- Multifamily, Mixed Utilize\n- FAST RESEARCH AND CLOSINGS\nLONG-LASTING PERMANENT FINANCING LOAN", "label": "No"}
{"text": "Color blindness is color vision deficiency, which means people with color blindness may be not aware of differences among colors that are obvious to the people without it. This package is designed to provide a collection of safe colors for plots such as heatmaps, pie chart, and try to find a solution for acceptable figures for all the end users.\nThere are lots of packages already collected lots of safe colors. I list some of them, but not limited here.\nFor this package, I will try to collect as much as possible safe color sets ready to use.\nThe tool used to simulate the color vision deficiency is called CVD simulator. I list some of packages here with CVD simulator.\nHans Brettel 1997(Brettel et al., 1997)\nFrancoise Vienot 1999(Viénot et al., 1999) (implemented in this package and package dichromat )\nGustavo M. Machado 2009(Machado et al., 2009) (implemented in package colorspace)\nClaire D. McWhite and Claus O. Wilke. colorblindr\nTo plot figures by colors of this package, there are three steps:\nselect correct safe color set.\nplot with the color set.\ncheck the plot by CVD simulator.\nFor example if we want to plot a heatmap.\nlibrary(colorBlindness) mat <- matrix(1:81, nrow = 9, ncol = 9) library(ggplot2) library(reshape2) mat1 <- melt(t(mat[9:1, ])) len <- length(Blue2DarkRed12Steps)-1 mat1$v2 <- cut(mat1$value, breaks = seq(0,ceiling(81/len)*len, length.out = len+1)) ht <- ggplot(mat1) + geom_tile(aes(x=Var1, y=Var2, fill=v2)) + scale_fill_manual(values=Blue2DarkRed12Steps) + theme_bw() # check the plot by CVD simulator cvdPlot(ht)", "label": "No"}
{"text": "- Mr. Mike Honcho: Keith, small suggestion… If the area to be tiled is small, consider looking at Travertine...\n- Ben W.: Not sure what makes most of those 15 places \"surreal.\" Perhaps if the list was renamed to \"15...\n- John Mackovic: Agreed. Jerry is probably the most important/influential owner since the AFL-NFL merger.\n- Bryan: At this point, do you blame him? The Death Star is full every single time the team takes the field. Until...\n- towski: and Johnny Walker…\nLooking For Something?\nRecent Flickr Photos\nRecently Came From\nDaily Archives: 30 October 30, 2009\nA church made famous by Washington Irving’s short story, “The Legend of Sleepy Hollow,” has rejected a couple’s request to hold a Halloween-themed wedding. Lisa Panensky and Jim Nieves signed a contract 13 months ago to get married on Halloween … Continue reading\nFour Utah County teenagers are upset after their trip to an American Fork McDonald’s, where they tried to rap out their order through the drive-thru. They didn’t leave with a Happy Meal; rather they were given a citation by police … Continue reading\nA seventh-grader and her 80-year-old grandfather are allegedly the first people to discover that President Barack Obama is related to all other U.S. presidents except one. BridgeAnne d’Avignon, who attends Monte Vista Christian School in Watsonville, traced that Obama, and … Continue reading\nWedding cakes are the center of any wedding party. The newly wed couples dream about their cake, however the cost of wedding cakes can skyrocket, also the possibility of falling over during transportation, heat and humidity for the outdoor weddings … Continue reading\nThese are the sandals that can detect metal while you walk, allowing you to find buried artifacts while strolling the beach. Link", "label": "No"}
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{"text": "In Short: Same Guy (Jake!), New Concept\nFor two decades, the Jake’s stores (Market & Delis, Coffee Co, Car Wash) have been serving our customers and at Jake’s Quechee Market & Café, we will continue to do that. Here in Quechee, you can expect the same friendly service and quality food that you’ve come to love at our other locations.\nWhat do we care about at Jake’s?\nSelection: fresh and local products, including a wide variety of grocery items\nService: friendly and helpful\nPrice: great prices on all your daily shopping needs\nOur market combines great prices (seriously!), convenience (we’re right here!), and, most importantly, a wide selection of products. We feel that our fresh produce, craft beer, delicious food, and seasonal offerings will be a welcome addition to this great community.", "label": "No"}
{"text": "May 23, 2023\n10 min read\nThe Best Hotels in Shanghai\nShanghai, the largest city in China, is a place where the pulse of modern development beats alongside a rich tapestry of history and culture, exemplified by its towering skyscrapers and traditional shikumen lanes. With its iconic skyline dominated by the Oriental Pearl Tower and Shanghai Tower, bustling shopping street of Nanjing Road, and historic charm of the Bund and Yuyuan Garden, Shanghai encapsulates a dynamic blend of East and West, old and new. To experience the city like a local, we recommend visiting these neighborhoods: Bund, with its iconic skyline and art deco architecture; the French Concession, with its tree-lined streets and charming boutiques; Jing'an, with its mix of high-end shops and trendy restaurants; and Xintiandi, with its blend of traditional Shikumen architecture and upscale dining options.\nThe Best Hotels in Shanghai\nNestled in a bamboo forest, this luxury resort on the outskirts of Shanghai houses a unique collection of Ming and Qing Dynasty reassembled antique villas. Each of the 26 carefully restored villas and 24 contemporary suites is equipped with elegant furnishings, private gardens, and courtyards, as well as heated swimming pools. The property also features an impressive cultural center, housing a collection of rare ancient Chinese artifacts and calligraphy, providing guests with the opportunity to immerse themselves in the rich heritage of China.\nThe property is also home to a wellness center, inspired by the region's traditional healing practices, which offers a selection of holistic therapies and treatments. The on-site dining options include an array of cuisine, ranging from Cantonese culinary artistry to Japanese delicacies. Other on-site amenities include a tea pavilion, a library, and a cigar lounge, as well a manicured lawns and lush gardens.\nAndaz Xintiandi Shanghai - a concept by Hyatt\nNestled in the Xintiandi district, this five-star property houses contemporary guest rooms and suites, each equipped with spacious work areas, complimentary high-speed Wi-Fi, and city views. Guests are invited to enjoy the renowned signature spa, which offers a range of Eastern and Western therapies, as well as the fully-equipped fitness center on-site. With a prime location just steps from a wide array of shopping, dining, and entertainment options, the property gives guests easy access to the surrounding city.\nThe property also offers several on-site dining options, including international cuisine at the all-day dining restaurant, and afternoon tea, pastries, or cocktails in the sleek lounge featuring live music performances. Additionally, the hotel's elegant and versatile meeting spaces can accommodate a range of gatherings.\nBanyan Tree Shanghai On The Bund\nPerched on the banks of the Huangpu River, this urban resort offers views of the Shanghai skyline. Guests can choose from 130 elegant rooms and suites that blend contemporary design with traditional Chinese elements, all featuring floor-to-ceiling windows with views of the cityscape. Along with an on-site spa, the property features an indoor pool, a well-equipped fitness center, and a variety of international dining options.\nThe award-winning spa at the hotel provides unbeatable personalized service, including tailor-made treatments that combine Asian traditions with modern techniques. Additionally, guests are invited to enjoy dining options ranging from Italian and Mediterranean cuisine to Japanese delicacies and local Chinese specialties.\nBellagio by MGM Shanghai\nThis five-star property effortlessly combines European-inspired sophistication with Asian design. The hotel houses 162 guest rooms and suites, each featuring rich fabrics, handcrafted details, and sweeping views of the city's skyline. Guests will also find on-site amenities, including a fully-equipped fitness center, an indoor pool, and an award-winning spa.\nThe on-site, Michelin-starred Italian restaurant, helmed by a renowned international chef, serves authentic Cantonese cuisine, while the lobby lounge serves an exceptional afternoon tea. The hotel is also perfectly located in close proximity to popular shopping, sightseeing, and nightlife in the city.\nBulgari Hotel Shanghai\nThis luxury hotel is perched on the upper 8 floors of a 48-story tower, offering panoramic views of the Shanghai skyline and Huangpu River. With spacious guest rooms and suites, the hotel prides itself on its refined Italian design and exceptional service. The property is also home to a 2,000-square-meter spa, a 25-meter indoor pool, and a fully-equipped fitness center.\nThe hotel also houses two of the city's leading dining establishments, known for their creative cuisine and outstanding service. The extravagant rooftop Italian restaurant serves exceptional Mediterranean fare, while the chic Chinese eatery on the 3rd floor specializes in contemporary Cantonese dishes that celebrate local flavors. Additionally, the bar on the 47th floor is the perfect spot for enjoying cocktails and views of the cityscape below.\nCapella Shanghai, Jian Ye Li\nNestled within the cultural preservation zone of Xuhui District, this luxury all-villa resort blends French and Chinese heritage. Designed by renowned architect Jaya Ibrahim, the property occupies a former community of shikumen, a traditional Shanghai architectural style, and is flanked by charming streets, boutiques, and restaurants in the city. The resort comprises 55 stunning villas and 40 Shanghai-styled residences, each equipped with generous living spaces, luxury furnishings, and private courtyards.\nAdditionally, the property's award-winning Auriga Spa offers a comprehensive menu of therapies, treatments, and healing practices, focused on organic and natural remedies derived from ancient traditions. The resort is also home to a much-celebrated Michelin-starred French restaurant, managed by acclaimed chef Pierre Gagnaire, offering contemporary French cuisine with an Asian touch. For guests seeking authentic local dining experiences, a short walk will lead them to some of Shanghai's finest fare and international cuisine.\nLocated in Shanghai's financial district, this luxury hotel houses 362 guest rooms and suites, each with views of the city skyline. Amenities include a fully-equipped fitness center, an indoor pool, dining options including five unique restaurants and lounges, plus a rooftop bar providing panoramic views of the city. Additionally, central to premier shopping, dining, and cultural attractions, the hotel is within walking distance of top destinations such as the Shanghai Tower and the Oriental Pearl Tower.\nThe hotel's multilingual staff is dedicated to ensuring a personalized guest experience for all guests, from arranging transportation to recommending and booking the best local dining and entertainment options. Also, each of the property's spacious guest rooms and suites features modern amenities such as smart room controls, high-speed Wi-Fi, flat-screen televisions, and luxury bedding.\nFairmont Peace Hotel\nLocated in Shanghai's Bund district, this iconic Art Deco hotel, constructed in 1929, effortlessly blends history and beauty with modern amenities. With views of the city's skyline, the award-winning property houses a diverse range of luxury accommodations, including 270 elegant guest rooms and suites.\nThe property is home to six acclaimed dining venues, each with its own unique character and menus, from authentic Cantonese fare to modern European classics. The hotel also features a world-class spa and wellness center, as well as an indoor pool. In addition to stellar service and luxurious amenities, the property also holds a well-regarded reputation for hosting glamorous events and weddings.\nGrand Hyatt Shanghai\nTowering above Shanghai, this luxury hotel is situated at the heart of the city's financial and business hub. Housed in the iconic Jin Mao Tower, one of the tallest buildings around the globe, the hotel offers guests a blend of sophistication and unparalleled views. The property features well-appointed guest rooms and suites, a modern fitness center, a serene spa, and an indoor sky pool, while its ideal location ensures direct access to top attractions, including the Oriental Pearl Tower and The Bund.\nWithin the hotel, guests are treated to an array of exciting dining options, from authentic Chinese dishes to Western favorites. The property's cloud-top-level restaurant allows visitors to enjoy their meals while taking in views of Shanghai's skyline.\nGrand Kempinski Hotel Shanghai\nLocated in the heart of Shanghai's Lujiazui financial district, this upscale 5-star hotel offers stunning skyline and Huangpu River views. Featuring elegant architectural design and unparalleled amenities, guests can enjoy on-site facilities including a spa, fitness center, heated indoor pool, and a tennis court. The property is also located in close proximity to the city's premier shopping and dining destinations, as well as the nearby metro station for easy transit throughout Shanghai.\nThe hotel is also home to five exceptional restaurants and bars serving dishes ranging from authentic Italian to Chinese and Mediterranean cuisine. Additionally, the property offers 14 versatile event spaces, including a grand ballroom capable of accommodating up to 380 guests.\nInterContinental Shanghai Expo, an IHG Hotel\nSituated on the shoreline of Huangpu River, this IHG property offers views of the city's iconic skyline. The hotel's ideal location offers guests convenient access to major tourist attractions, such as the world-famous Expo Center, Mercedes-Benz Arena, China Art Museum, and the Huangpu Riverside Corridor Park. The hotel features 384 guest rooms and suites, all complete with scenic riverfront and city views. In addition to the well-appointed accommodations, guests can enjoy a 25-meter indoor swimming pool, a fully-equipped center, and on-site spa treatments. The property also includes three exceptional dining options, serving Cantonese cuisine, European dishes, or Italian specialties, while the on-site bar and lounge provides an extensive selection of drinks.\nInterContinental Shanghai Hongqiao NECC, an IHG Hotel\nLocated in the heart of the Hongqiao Central Business District, this five-star luxury hotel offers convenience and sophistication. Adjoining the National Exhibition and Convention Center (NECC) and within a short distance of the city's finest attractions, guests can enjoy easy access to the surrounding area. The hotel houses 536 rooms and suites, each complete with floor-to-ceiling windows providing cityscape views, with amenities including a heated indoor pool and fully-equipped fitness center\nGuests can enjoy an array of dining options on-site, including authentic cuisine at the Chinese restaurant, diverse international flavors at the all-day dining venue, or cocktails and light bites at the lobby lounge. The hotel also houses an impressive ballroom, making it an ideal choice for hosting events and conferences.\nInterContinental Shanghai Jing’ An, an IHG Hotel\nThis luxury hotel is within walking distance of key attractions such as the Jing'An Temple and West Nanjing Road, as well as the railway station and metro stop. The property features guest rooms and suites equipped with floor-to-ceiling windows providing city views, plush furnishings, and modern technology.\nThe hotel's dining options include diverse international cuisine and classic Chinese fare. Guests can also enjoy the on-site spa and wellness center, which includes a heated indoor pool, a steam room, and a fully-equipped fitness center. The property also offers extensive meeting and event facilities, perfect for hosting conferences, weddings, or special celebrations.\nInterContinental Shanghai Pudong Hotel, an IHG Hotel\nNestled in the heart of Shanghai's Pudong district, this five-star property, a part of the IHG group, features modern amenities, elegant interiors, and impeccable service. With a prime location near top attractions such as the iconic Oriental Pearl Tower and the financial hub of Lujiazui, the hotel is a perfect base for guests looking to explore the city.\nThe accommodations include 398 rooms and suites, each providing panoramas of the city's skyline. Guests can also enjoy on-site dining options, blending both international and local flavors, as well as a spa, a fully-equipped fitness center, and an indoor pool.\nJing An Shangri-La, Shanghai\nThis luxury hotel combines modern elegance and world-class service. The property is home to 508 guest rooms and suites with city views, in addition to a temperature-controlled indoor pool, a fully-equipped fitness center, and the renowned CHI, The Spa.\nGuests can enjoy a range of on-site dining options, including the hotel's signature restaurant, which serves traditional and contemporary Chinese cuisine, a venue serving authentic Southeast Asian dishes. and an elegant international buffet. Additionally, the hotel lobby provides light fare and cups of tea for guests to enjoy.\nJumeirah Himalayas Hotel Shanghai\nLocated in the Pudong district, adjacent to the iconic Himalayas Center, this 5-star luxury hotel blends modern Chinese design elements and ancient Himalayan culture. From the property, guests have easy access to shopping, entertainment, and historical sites, as well as the metro station and the famous Shanghai Maglev Train. Housing 401 spacious guestrooms, including 62 suites and premium residences, the hotel provides panoramic city views, elegant bathtubs, complimentary Wi-Fi, and LCD flat screen TVs.\nGuests can enjoy Cantonese delicacies at the signature Chinese restaurant or global and local dishes at the all-day dining restaurant on-site. The property also features a lobby lounge, a rooftop bar, a fully-equipped fitness center, a spa, and an indoor heated swimming pool.\nKerry Hotel Pudong Shanghai\nLocated in Pudong's financial district, this luxurious 5-star hotel offers modern elegance and traditional Shanghainese hospitality. With a striking design, the property features panoramic views of the city skyline and lush green parks. Guests can also enjoy close proximity to top attractions, such as the Oriental Pearl TV Tower and the Jin Mao Tower, as well as easy access to public transportation, including the high-speed Maglev train station nearby.\nThe hotel houses 574 spacious guest rooms and suites, each complete with sleek furnishings and modern amenities. On-site, guests are invited to enjoy a well-equipped fitness center, an indoor swimming pool, and a spa. Additionally, the property's selection of dining options ranges from innovative Asian cuisine to international fare.\nLe Sun Chine\nSituated in the heart of Shanghai's historic French Concession, this boutique hotel is housed within a beautifully restored 1930s garden villa. With only seven suites and six guest rooms, the property offers exclusivity and intimacy, as well as modern amenities including flat-screen televisions, ambient lighting, and rainforest showers.\nThe property is also home to a picturesque courtyard and a fusion restaurant serving up innovative international cuisine. Each room has its own unique character, featuring refined furnishings and hand-selected artwork, while communal spaces like the library, lounge, and on-site spa are perfect for relaxing on-site. Additional amenities include a 24-hour butler, complimentary high-speed Wi-Fi, and tailor-made sightseeing excursions organized by the attentive staff.\nLes Suites Orient, Bund Shanghai\nSituated on the iconic Bund, this property offers views of the famous Pudong skyline and the historic Shiliupu Waterfront. Designed with a blend of Eastern and Western styles, each of the hotel’s 168 suites features sleek furnishings, spacious living areas, and modern technology. A wide array of dining options, from innovative French cuisine to authentic Cantonese dishes, is available on-site. Guests can also enjoy a range of additional amenities during their stay, including an intimate cigar lounge, a chic cocktail bar, and a fully-equipped fitness center.\nMandarin Oriental Pudong Shanghai\nNestled in the heart of Shanghai's financial district, this five-star property offers expansive skyline views and a selection of guest rooms, suites, and serviced apartments. The hotel's impressive array of amenities includes a serene spa, a well-equipped fitness center, an indoor pool, and a variety of dining options ranging from an intimate Oriental-style tea house to a gourmet restaurant.\nThe generously sized rooms, featuring elegant marble bathrooms and city panoramas, are perfect for relaxing. For dining, guests can choose from the diverse culinary options on-site, including Chinese, seafood, steak, or an all-day dining option with an international buffet. The property is also home to an award-winning spa, occupying two floors and offering wellness treatments inspired by ancient traditions.\nPark Hyatt Shanghai\nTowering above the city skyline, this luxury hotel is located in the heart of Shanghai's Lujiazui financial district in the iconic Shanghai World Financial Center, known for its unique design and proximity to the city's prime attractions. The hotel offers world-class accommodations and sweeping panoramic views of the city and Huangpu River. Guests are invited to enjoy the hotel's spa and wellness center, as well as the four on-site dining establishments, including a Michelin-starred restaurant.\nEach of the hotel's 174 guest rooms and suites are elegant and spacious, featuring floor-to-ceiling windows, high-speed Wi-Fi, Nespresso machines, luxury beds, and marble bathrooms. The hotel is also home to a Club lounge providing numerous exclusive benefits, such as personalized check-in, daily breakfast, and all-day refreshments. The central location of the property also makes it an ideal choice for guests looking to explore the city.\nPudi Boutique Hotel Fuxing Park Shanghai\nNestled in the heart of the Xintiandi district, this boutique hotel has views of the verdant Fuxing Park. With world-class shopping, dining, and entertainment options just steps away, the property features 52 suites equipped with elegant furnishings, modern amenities, and private balconies. The hotel also houses a spa center and a fitness facility complete with a yoga room. Guests can also enjoy the rooftop dining venue, which serves contemporary cuisine while offering panoramic views of the city skyline.\nRegent Shanghai Pudong\nLocated in the heart of Shanghai's Pudong district, this property offers a skyline view and provides guests with easy access to prime attractions such as the Oriental Pearl Tower and Yu Garden.\nGuests can enjoy diverse dining options on-site, ranging from authentic Cantonese to refined international cuisine. The hotel also offers modern amenities, including a spa, a fully-equipped fitness center, and an indoor pool.\nSofitel Shanghai Hongqiao\nLocated just minutes away from the National Exhibition and Convention Center and Shanghai Hongqiao Airport, this five-star hotel features a French-inspired design and easy access to nearby transportation. The property houses 354 rooms and suites, each complete with contemporary furnishings, art, and modern amenities, as well as an indoor pool, a well-equipped fitness center, and a spa.\nThe property is also home to dining venues serving authentic Cantonese cuisine or buffet spreads at the all-day dining venue, and the chic lobby lounge and executive lounge are both great spots for meetings or unwinding with a drink.\nThe Langham, Shanghai, Xintiandi\nNestled in Shanghai's Xintiandi district, this hotel blends traditional Chinese charm and contemporary sophistication. The property houses 357 elegant rooms and suites, each equipped with modern technology and amenities. Guests can also enjoy the award-winning Chuan Spa, a fitness center, and a heated indoor pool on-site. With its close proximity to numerous entertainment, dining, and cultural attractions, the property gives guests easy access to the best that Shanghai has to offer.\nDining options on-site include a variety of cuisines, ranging from European-inspired delicacies to Cantonese fare. There's also an on-site café that provides a relaxed setting for afternoon tea, while the sophisticated cocktail bar is an great spot for an evening nightcap.\nThe Peninsula Shanghai\nLocated in Shanghai's historic Bund district, this five-star property offers panoramic views of the Huangpu River and Pudong skyline. The hotel's rooms and suites feature Art Deco-inspired interiors, marble bathrooms, and modern amenities. Guests can also enjoy the on-site spa, indoor pool, and fully-equipped fitness center, as well as the on-site Michelin-starred dining options.\nIn close proximity to famous landmarks, high-end shopping destinations, and vibrant nightlife, the hotel provides an ideal base for exploring. Guests can also take advantage of personalized services from the attentive staff—such as custom-tailored city tours and curated cultural experiences\nThe Portman Ritz-Carlton, Shanghai\nNestled in Shanghai's commercial district, this luxury five-star hotel features spacious accommodations with skyline views, modern facilities, and impeccable service. Guests can enjoy an array of dining options, ranging from fine international cuisine to more casual, local fare. The property is also home to a fitness center, indoor pool, and a luxurious spa.\nConveniently located within walking distance of major attractions such as Nanjing Road and the historic Jing'an Temple, this hotel is a great base for exploring Shanghai. Guests can also enjoy the convenience of the adjacent metro station and the short drive from the Shanghai Railway Station.\nThe Puli Hotel And Spa\nIn Shanghai's Jing'an District, this urban luxury retreat is in a prime location, giving guests easy access to Jing'an Park and the famous shopping destination, Nanjing West Road. Housing 229 rooms and suites with floor-to-ceiling windows, the hotel provides views of the city skyline, accompanied by modern amenities and top-notch service.\nAs an environmentally-conscious hotel, The Puli Hotel and Spa prides itself on sustainable practices to ensure the comfort and well-being of the guests and the planet. A key feature of this property is its award-winning spa, where guests can enjoy treatments and massages that blend ancient Chinese traditions with modern techniques. The location also features a fully-equipped fitness center, a 25-meter indoor heated pool, and a lounge offering various dining options, from international favorites to innovative cocktails.\nThe Ritz-Carlton Shanghai, Pudong\nTowering over the Huangpu River, this 5-star accommodation offers exceptional dining options, elegant spa facilities, and personalized service. Guests can enjoy Oriental Pearl Tower and city skyline views, as well as seamless access to key landmarks, such as the Bund, Yuyuan Garden, and the Shanghai World Financial Center.\nEach of the property’s beautiful guest rooms combines Art Deco elements with contemporary Chinese design and a range of modern amenities. Guests can also enjoy dining options ranging from innovative fine dining to afternoon tea.\nThe Shanghai EDITION\nThe Shanghai EDITION is a luxury hotel with 145 guest rooms and suites. This striking property offers city views, exceptional dining options, and attentive service. Notable amenities at the hotel include a fully equipped gym, an indoor pool, a 24-hour business center, and unique social spaces. Its strategic location places guests within walking distance of the city's most iconic attractions, commercial districts, and cultural institutions.\nThe hotel's dining options feature two restaurants, a specialty bar, and a rooftop lounge, serving local and international cuisines, cocktails, and a carefully curated wine list – all while providing panoramic city views. Additionally, the hotel's spa offers fully immersive treatments by professional therapists.\nThe St. Regis Shanghai Jingan\nNestled in the heart of Shanghai's Jingan District, this luxurious urban retreat is in a coveted location within walking distance of major attractions, including the iconic Jing'an Temple and the upscale shopping hub of Nanjing West Road. The hotel features 491 guest rooms, each complete with custom art installations and modern amenities, as well as 5 dining venues.\nUpon arrival, guests are pampered by the hotel's signature, world-class butler service, dedicated to ensuring a seamless and personalized stay. The hotel is also home to a spa sanctuary offering tailored treatments, as well as a fully-equipped fitness center and indoor heated pool.\nThe Sukhothai Shanghai\nThis 5-star hotel is in a prime location in the heart of the city, placing guests in easy reach of key attractions, such as the Jing’an Temple, Nanjing Road, and the Bund. Designed by renowned international architectural firm Neri&Hu, the establishment features a perfect blend of modernity and traditional elements. The 201 well-appointed rooms and suites feature floor-to-ceiling windows and include modern amenities and conveniences.\nOn-site dining options include an elegant all-day dining restaurant offering international cuisine, a Michelin-starred Italian venue, and a lounge with a remarkable selection of fine wines and authentic Cantonese cuisine. Guests can also enjoy a fully-equipped wellness center, featuring a 25-meter indoor heated pool, fitness facilities, and spa treatments.\nThe Yangtze Boutique Shanghai\nThis boutique hotel brings together the best of traditional Chinese luxury and modern amenities. Located in the heart of the city, the hotel is just a stone's throw away from popular attractions. The property features 96 elegant rooms and suites, each complete with stunning Art Deco touches, 1930s-inspired design, and contemporary comforts.\nGuests can enjoy the on-site Chinese restaurant, which offers delicious Cantonese and Shanghainese dishes, or try the contemporary all-day dining option that serves international delicacies. The hotel also features a rooftop garden and bar where visitors can enjoy views of the city skyline and artisanal cocktails or traditional English afternoon tea. Guests are also invited to enjoy the on-site fitness center and spa treatments.\nURBN Boutique Shanghai\nLocated in the heart of Shanghai's Jing'an District, this eco-conscious boutique hotel offers guests a unique combination of modern luxury and sustainable design. Housed within a reclaimed warehouse, this property houses 26 rooms and suites, each featuring custom furnishings made from locally-sourced, recycled materials.\nThe hotel also includes a lush rooftop garden, a focus on green initiatives, and an outstanding location within walking distance of key attractions. Additionally, guests can enjoy the hotel's award-winning restaurant, known for its farm-to-table concept and commitment to organic, locally-sourced ingredients.\nW Shanghai - The Bund\nLocated on the iconic Bund, this hotel houses 374 guestrooms and suites, all complete with chic décor, modern technology, and views of the Huangpu River and the Pudong skyline. The property is home to a range of facilities, including a heated indoor pool, a spa, and a fitness center, as well as a selection of dining options.\nGuests can enjoy delicious Chinese and international dishes, ranging from modern twists on traditional Shanghainese cuisine to innovative global favorites. For a taste of local nightlife, the trendy rooftop bar offers signature cocktails and views of the city skyline.\nWaldorf Astoria Shanghai on the Bund\nLocated in the heart of Shanghai, this five-star property combines timeless elegance with modern amenities. Guests can enjoy views of the iconic Pudong skyline, take a stroll along the riverside promenade, or immerse themselves in the vibrant dining and shopping scene within walking distance of the hotel. This hotel comprises a meticulously restored heritage building and a contemporary tower, seamlessly blending European sophistication and the charm of Old Shanghai. The accommodations range from elegant guestrooms to luxury suites, all of which include high-speed WiFi, plush bedding, and marble bathrooms.\nWith several world-class dining venues on-site, guests can enjoy international cuisine or afternoon tea with views of the scenic waterfront. The hotel is also home to an award-winning spa, along with a heated indoor pool and a fully-equipped fitness center.\nWanda Reign on the Bund\nSituated along the Huangpu River in Shanghai, this luxury hotel blends culture, art, and elegance. With views of the Bund and the Lujiazui skyline, the property features a blend of Eastern and Western design elements and houses 193 guest rooms and suites, all complete with Art Deco-inspired design and cutting-edge technology. The hotel also offers modern amenities, including a serene spa, an indoor swimming pool, and a well-equipped gym.\nThe property’s three signature restaurants serve a wide range of cuisines, from Japanese and French to modern Shanghai-style delicacies. Each dining venue has its own unique ambiance and décor, and the rooftop bar is the perfect space for guests to unwind with a cocktail and take in the Shanghai skyline.\nSign up for Safara", "label": "No"}
{"text": "How It Works\nAltitudeCard.com is a privilege card for skiers and snowboarders.\nBy producing your card or quoting your unique membership number you can save £100’s each year on 1000’s of exclusive deals around the world in over 500 ski resorts. Save on holidays,equipment rental, ski/snowboard schools, restaurants, mountain restaurants, transfers and much more. AltitudeCard.com can also provide great savings in the U.K. including travel insurance, snowdomes, airport parking, mountain sports shops and health spas.\nStart receiving discounts immediately\nSign up for your AltitudeCard.com today and we’ll immediately email you with your unique login details, giving you access to our members section which displays all the discounts and benefits available to AltitudeCard.com members. You will receive your membership card within 15 days (slightly longer over festive breaks or if overseas). Once you have your unique login details you can start making savings immediately on many products and services, you will be able to pre-book your chosen ski/snowboard shop & school. Your unique card can be accepted in over 520 European and North American resorts as well as various U.K establishments.\nTypical savings per person\n|Online Equipment Rental & Boots 6 days Europe||Save £68|\n|Winter Sports Insurance (Single Trip – 8 days – Europe)||Save £21|\n|Winter Sports Insurance (Annual Policy – Europe)||Save £56|\n|Ski/Snowboard School (Group Lessons 6 mornings)||Save £30|\n|Ski/Snowboard Lessons (Private 2 mornings)||Save £54|\n|Transfers (Return)||Save £38|\n|Mountain Restaurants||Save £20|\n|Resort Restaurants||Save £60|\n|Airport Parking (Including one nights accommodation)||Save £49|\n|Holidays and Accommodation||Save £120|\n- If your favourite retailer isn’t mentioned, let us know and we’ll do our best to add them to our collection of partners.\n- Introduce a friend and receive a £10 M&S, Snow & Rock or Amazon voucher for each new member that signs up to AltitudeCard.com*.\n*New members must quote your membership number when first joining. Cannot be used in conjunction with any other offers.", "label": "No"}
{"text": "Becky Crowe, CEO/Executive Director\nStart Date: 2019\nBecky Crowe has an extensive leadership background in education including roles in management, strategic development, philanthropy, research, policy, and community engagement. Most recently, she served as a Fellow on the Chan Zuckerberg Initiative's Education team, including responsibility for grant making, strategy, and research focused on child development. Prior to that, Crowe was a partner with Bellwether Education Partners where she launched the Talent Advising practice to increase clients' organizational effectiveness while building a culture committed to diversity and inclusion. She provided targeted strategic counsel to numerous school districts and education nonprofit organizations, as well as corporate clients such as Microsoft and Google. Crowe also served as the Executive Director of Partners in School Innovation with a mission of transforming the quality of early literacy teaching and learning in San Francisco Bay Area schools. Ms. Crowe is a distinguished alumna of Stanford University, having earned a Bachelor's Degree in English; a Master's Degree in education from the Stanford School of Education; and a Master's Degree in management from the Stanford Graduate School of Business.\nHelen R Benson, Executive Secretary\nStart Date: 2001\nHelen Benson can be contacted via email at HBenson@claytonearlylearning.org\nSarah Berkman, Vice President, Development\nStart Date: 2015\nSarah Berkman leads the development and marketing and communications department for Clayton Early Learning. She is responsible for prospecting, cultivating and stewarding donors and grants and helping to advance the brand and recognition of the organization. Prior to joining the Clayton team in February of 2015, Sarah worked for the University of Northern Colorado as the Director of Corporate and Foundation Relations. She also worked for the Colorado History Museum and supported the Capital Campaign efforts for the History Colorado Center that opened in spring 2012. Sarah has more than 20 years of experience in management positions with various industries, both for profit and nonprofit, with skills in strategic planning, fundraising, program implementation, and community networking. Sarah attended Trinity College where she obtained a Bachelor's Degree in Liberal Arts. Additionally, she attended University of Denver, Daniels College of Business earning an International Master's Degree in Business Administration.\nCathy McCarty, Senior Vice President, Learning & Talent\nStart Date: 1994\nCathy McCarty has over 27 years of management and human resources experience in both the for-profit and not-for-profit sectors. She began her career as an elementary school teacher in the Minneapolis/St. Paul metropolitan area. With a move to Colorado, she joined Jefferson Bank & Trust, a community bank in Lakewood in 1980. Cathy served as Senior Vice President, leading division responsibilities including human resources and payroll, marketing and advertising, operations, and general services. During her tenure, she actively participated in education-related community involvement projects through the Colorado Alliance of Business and Junior Achievement. Since joining Clayton in 1994, Cathy has supported early childhood programs in diverse capacities including directing human resources, managing administrative services and leading Early Head Start and Head Start programming. In her current role as Vice President of Learning & Talent, Cathy manages professional development services for Clayton. Cathy McCarty received her Bachelor of Arts in Psychology and elementary education credentials from Hamline University in St. Paul, Minnesota. She is a graduate of Buell Early Childhood Leadership Program and holds an MA in Education Administration and Policy Studies, with emphasis on Early Childhood Care and Education.\nPaula Smith, Vice President, Educational Services\nStart Date: 2015\nPaula Smith is Vice President, Educational Services. She has over 21 years of experience working in Early Head Start and Head Start programs serving culturally diverse families and children birth to age five. Since joining Clayton, Paula has led and managed all aspects of education, health, mental health, early intervention, and child and family services to support school readiness. She has also led and directed community partnerships throughout the State to leverage quality early care and education programs. Paula currently provides leadership and oversight of Clayton's early childhood programs with an additional focus on strategic initiatives that includes professional development and coaching throughout Colorado. Paula earned a Bachelor of Science in Criminal Justice from Indiana University and a Master's Degree in Early Childhood Studies, specializing in management, administration and leadership from Walden University.\nJane M.K. Williams, Chief Financial Officer\nStart Date: 2018\nJane M.K. Williams is the Chief Financial Officer. Jane has been working in nonprofit accounting and finance with mission-focused educational organizations for over two decades. Prior to joining the Clayton Early Learning team, she was the Director of Reporting and Compliance/Controller for the Science Museum of Minnesota. Jane also spent twenty years in higher education at the nationally recognized liberal arts institution, the College of Saint Benedict. During her tenure, she served as controller and served in other finance-related positions. Additionally, she has worked in the for-profit law and small-business manufacturing/retail industries.\nShe brings her experience and expertise in accounting, strategic planning, debt financing, organizational change, project implementation and process change to Clayton Early Learning. Jane holds a Bachelors of Arts in Business Administration and Accounting.\nDevelopment / Fund Development / Fund Raising / Grant Writing / Major Gifts\nFinance & Administration\nProgram / Program Planning", "label": "No"}
{"text": "swearing bluish kill at me and, frankly, I can’t create head nor tail from it. I love a bit of a rubdown. They calms me. I’ve got a high-stress tasks (don’t ask), i enjoy need just a bit of a schvitz and a stretch in the gym, a lounge during the hot fog, following some a deep-tissue pummel. Absolutely a female at my gymnasium and she constantly completes myself down during the appropriate and time-expected manner. And I also’ve never ever believe things regarding it. What i’m saying is, who willn’t become a pleasurable ending? It’s not also anything. You put the girl a tip and state, “afterwards,” and you also feel well and smoothed on for a high-octane nights. Just how calm will you getting with a hard-on? And who willn’t become a stiffy on the table? It’s just another little the bod that needs de-stressing. In any event, the girlfriend—I state the sweetheart, but we have been together for a couple of decades and now have had gotten a youngster, and I genuinely believe that she is it, offer or take—she overheard me and multiple friends creating a bit of a banter about hands jobs, and she cornered me after and said, “ever engage?” And I also stated, “No, except for a polish after a massage.” And she goes inter-fucking-galactic. “You’re infidelity on me personally while the kid, and you’ve started carrying it out all the time we have been together. I was thinking you treasured myself. Personally I think deceived and humiliated. What have always been we probably tell little Taylor?” Bloody hell. We never noticed this coming. Together with thing is actually, i am as nice as gold. I never play overseas. Dad had been your dog and I keep in mind just what it place my personal mother through. In any event, exactly what can we say? It doesn’t imply anything, appropriate?\nBetter, yes and no. We have secure cheating quite a bit right here. But, apparently, your own ever-alert penises bring brief recollections. I sometimes think about Esquire visitors’ penises as a troupe of bored meerkats all abreast of their hind legs, sniffing air for hot poon; never ever however, usually questing with bad, ravenous, beady little smirks. And then i need pure zarejestruj siÄ™ to think of something else, like Buddhist sandpainting. 1st suggest create is that the concept of something and it isn’t cheating isn’t down seriously to the person within the pier. If you’ve become fouled, it isn’t for your other professionals to express if they are only playing golf ball. If you have already been robbed, it isn’t for any robber to keep up their fingers and state the guy don’t imagine you’ll miss it. Therefore, infidelity is not what you are able get away with. Its exactly what she seems regarding what you obtain aside with. Together with truth is some couples move their sight at a hand job in a spa, many lovers shrug at an intoxicated gobble in a dressing place. Not most. And only if they’re playing away themselves or they do not care much about you one way or the some other. The top matter let me reveal: is it possible you believe as sanguine if she happened to be doing it for you? Say, after a pedicure she had gotten a generous fingering? Not likely. The one thing with men and hand opportunities is because they like to picture they are nearer to genital stimulation than fornication, whereas women you shouldn’t even always consider their own boyfriends creating one off the hand by themselves. The major price is it involves a 3rd party. And now you need to consider, does it matter exactly who this third hand belongs to? In the interests of debate, let’s hypothetically say you have got no interest to guys. Is it possible you be happy with a happy closing from a male masseur? So, it’s not merely a mechanical relief, is it? As the mechanic things. So there’s a telling anecdote about this. A shy cello member with a prominent symphony orchestra is found on journey when you look at the asia. A horn player says to your that, if he fancies they, absolutely a truly close massage parlour adjacent to the lodge. Never ever creating done such a thing along these lines, the cellist nervously guides in for an hour’s relaxing stroke. The masseur’s only complete one knee when he’s sporting an expectant stiffy like a drumstick, and she smiles and winks and says, “Would you like a wank, soldier?” “Oh, well, actually, yes. I would personally fairly,” claims the cellist. “OK,” she replies, visiting the doorway, “I’ll be in five full minutes when you have done.” You find, it wasn’t a thing. When it was not something, because place it, you could will have seen to yourself, nevertheless genuine point would be that she cares. You would mind much more if she failed to. Plenty of warm somebody are shielding all of them from vulnerability of their prefer. You had a duty not to ever allow the mommy of your own son or daughter getting hurt by the woman fascination with your. And when that twinges with guilt, better it isn’t really because a sordid tug in the gym, it’s because you have were not successful at the very first task of being in love, which will be to make the individual that supplies their like back become secure.", "label": "No"}
{"text": "In keeping with the brave and independent tradition of our state, Texas Home School Coalition (THSC) has always taken a bold and assertive approach to promoting and defending home schooling. We believe the best defense is a good offense and that Texans should have freedom in their children’s education decisions. This approach, by the grace of God, has effectively allowed Texas to be one of the best home schooling states in the nation.\nWhy THSC believes all parents should support the freedom for ESAs and Tebow\nHB 1335 and SB 3 redirect tax dollars currently earmarked to fund a child’s education at their local public school to an ESA for the child’s benefit. These bills would allow parents who choose to participate the freedom to use these funds to pay for curriculum, textbooks or certain other services for children with disabilities.\nThese bills do not affect parents who choose not to utilize ESAs.\nTHSC has protected and bolstered our current freedom within the language of these bills by requesting the addition of four key protections, including a prohibition against any new regulation and protecting the curriculum choices of participating families from religious or content-based discrimination.\nAs these bills stand, they remove control from the government and give freedom to parents. Nothing in the language of these bills limits or is detrimental to the freedom of home schoolers and if that changed, we would sound the alarm and oppose the bills.\nAs parents across the nation seek alternatives, school choice (including ESAs) is a hot topic. Five other states have passed similar legislation to what Texas is now considering. According to researchers from the Goldwater Institute, none of the these states have seen an increase in regulation of home schooling.\nIn just one example, 100% of participating parents in Arizona consider ESA programs successful.\nTo say that other parents should not have the freedom to choose ESAs because that might possibly, in some way, one day endanger my freedom is a mistake. We believe in freedom and we understand it is at risk every moment the legislature is in session. But these bills don’t jeopardize our freedom.\nWe must remain dedicated to promoting and defending liberty, as we have for the last 30 years.\nHow THSC’s philosophy differs from HSLDA’s\nThe Texan journey to home schooling freedom has been unique and arguably the most successful of any state. THSC’s position has not wavered: We believe we must fight the battle before us fearlessly protecting and expanding our liberty.\nVirginia-based Home School Legal Defense Association (HSLDA), though most often a THSC ally, has differed with THSC at times over the years on Texas home school policy issues. Their positions on ESAs and the now the Tebow bill are recent examples of our contrasting philosophies.\nHSLDA fears that redirecting tax dollars to home schoolers through ESAs will draw more attention to us and likely result in the loss of freedom through government control. Those were the same arguments against Attorney Shelby Sharpe’s Leeper v Arlington ISD case in 1985.\nSome were afraid the Leeper lawsuit would increase state scrutiny of home schoolers and the court ruling itself would result in a loss of freedom – although scores of home school families were being prosecuted. The case was filed anyway. The Leeper decision, however, ended the mass prosecution of Texas home schoolers and laid the foundation for our future freedoms.\nIn the early 2000’s, HSLDA warned not to use the term “homeschool” in legislation because it would draw attention to us and could lead to state regulation. THSC’s approach, however, was to be bold and specific in using the term “homeschool” to make clear in statute that home schoolers could not be discriminated against in college admission or dual credit classes.\nAgain, the fears of increased regulation were unwarranted. THSC continues to this day to cite the specific terms added to the statute, successfully advocating for home school students facing discrimination. Countless lives have benefited from these reforms.\nIn 2007, when THSC worked to change the law and end discrimination of home schoolers in PSAT testing, HSLDA warned that adding a definition of “homeschool” to the statute would result in limitations on home school freedom in Texas. THSC added the language anyway and again, the predicted limitations never came.\nIn fact, Texas has more freedom today than at anytime in modern history.\nHSLDA has recently opposed the “Tim Tebow” legislation (HB 1323 and SB 640) on which they were neutral in 2013 and 2015 when it passed the senate. These bills would allow home school students freedom to participate in extracurricular activities in their school districts as 34 other states already allow.\nHSLDA now opposes the legislation for its use of nationally normed standardized achievement tests to show academic progress, although the previous legislation included the same requirements. School districts have no authority over these tests and THSC believes parents should have freedom to choose for their child to take the tests and participate if desired.\nHSLDA does refer to many studies comparing home school student’s scores on nationally normed standardized achievement tests to prove the academic success of home schoolers, so they are not entirely opposed to such tests.\nWhere do we go from here?\nThe Texas home school community is known for strongly defending liberty and we must not back down. THSC supports the Tebow and ESA bills because we believe in freedom for parents to make decisions for their own kids.\nWe will continue to stand for liberty, closely monitoring these bills and thousands of others in the legislature this session. Should these or any other bills change in such a way that would jeopardize home schooling freedoms, we will oppose them and call on the home school community to do the same.\nIt is a mistake to think that we can keep our current freedoms and secure our future by opposing new freedoms. Instead, let’s continue the Texas tradition of fearlessly protecting and expanding our God-given right to raise our own children as we believe is best.\nFor 30 years THSC has fought for you, advancing and protecting home school freedom. By God’s grace and with His strength we will continue to do so.\nStand boldly with us in Keeping Texas Families Free:", "label": "No"}
{"text": "Giant vesical calculi: experience with management of two Nigerians\nAbstractTwo cases of Giant Vesical Calculi were encountered in a semi-urban health facility (Nakowa Hospital, Yauri, Nigeria). careful clinical evaluation and investigation is important in the work up of the patients. surgical technique and accurate diagnosis are essential in their treatment.\nNigerian Journal of Surgical Research Vol. 7(1&2) 2005: 203-205", "label": "No"}
{"text": "My son loves Mickey Mouse Clubhouse and wanted a Mickey Mouse Clubhouse Birthday Cake for his 4th birthday. I did search online for ideas and came up with this cake. The base cake is a 2 layer 12″ Chocolate Devils’ Food cake with Oreo Buttercream filling. The fondant is buttercream fondant using Duff’s ready made fondant (tastes great!) and also nice that it can be purchased in black.\nThe Clubhouse, Black Mickey head, and the Black base for the handy balloon are made with rice krispie treats covered in chocolate and then covered in fondant. The yellow foot doorway, up-slide, and Handy Balloon are 50:50 fondant and gumpaste mixed and molded into shape. The little characters came from a board game my son has, which worked out well for the size and I was able to include all of the characters on the cake. This cake was enough for 15 kids and about 15 adults with cake left over.\nTo get the black Mickey head and ears round as well as the clubhouse I used the Wilton Ball Pan. Dowling was used to attach the hand to the black base through to the cake, the ears to the head, and one straight through the black Mickey head, clubhouse, and cake. The cake was extremely stable and survived a half hour car ride to the party site (on my lap not in the back of a car).", "label": "No"}
{"text": "When you configure TFS Lab Management in a single box, and you follow the instruction that you find on MSDN, probably you will encounter this error when you configure the host tab.\n- The following host is unusable for Lab Management: xxxx in host group: “All Hosts”. To make it usable, connect at least one of its physical network adapters to a valid network. Then, verify the host group again to ensure that the problem has been resolved. *\nThis is due to the fact that you are configuring everything in a single box, and lab management complains that he need a physical network to communicate with the host group. Thankfully the Lab Management Blog as a dedicated post on how to solve the problem, just follow the instructions and run\nC:\\Program Files\\Microsoft Team Foundation Server 2010\\Tools> TFSConfig lab /Settings /NetworkLocation:“Internal Network”\nTo solve the problem. Do not forget to check the post for useful suggestions for One Box configuration.", "label": "No"}
{"text": "Medical insurance you could possibly consider from the supervisor is commonly decrease than obtaining a code with your. Taxpayers must itemize the girl discount after they desire to keep your ex wellbeing-attached expenses. A new Levy Loss and commence Job Act associated with 2017 increased the standard reduction significantly, thus listing is an excellent less really feel in many taxpayers. A signed up era to secure a Clinical Sector ran in The fall of. one, 2021, if you wish to January. 10, 2022, regarding canceling in 2022. Reward Listed may be accessible in certain situation.\n- In line with the set up, it could type in national canceling or perhaps it could please take a neighborhood program connection.\n- Should you have sets of plans, for example should you have Medicare along with a more signal, you will get a number offering the process as well as loss.\n- Of course,if you and your loved ones stack drugs, you’lmost all need to evaluation cocaine reporting.\n- Including, your primary company may necessitate you to employ before authorization with regard to a great connection, as a grade you can not necessarily.\nFor example, in case you’re also coming from a PPO design, much of your program code probably have assistance interconnection legislations. Of course, you could have teams of health care insurance strategies hamilton association with other organisations. Dual reporting often means better move forward health insurance costs but sometimes retailer away-of-tote expenditures pertaining to associates, for instance individuals who take 1000s of treatment help. The grade medical health insurance provides teams of forms of peace of mind methods. The methods help with the values from the key policy by visiting items like high deductibles or the expense of hospital stay. You can even find grade policies which are bunch-ons producing a different type of peace of mind which is not included in your primary program code, such as quest peace of mind as well as handicap assurance.\nIt’s the topic assurance that fits a new Affordable Interest Act requirements for necessary attention. UnitedHealthcare provides shining monetary power reviews and has a link regarding Rogues across the nation. Janet Research specializes from auto insurance, citizens guarantee, and initiate health care insurance with over two decades of expertise helping developments, regulation, and start posting support stories. Your ex extended employment in peace of mind features stints from customer service and start promoting exclusive series regarding confidence. In comparison to guidelines to learn if you need to put on a couple of competitive methods, pause and consider the benefits as opposed to problems with producing thus.\nSearch for health care insurance is determined by which usually’utes offered to anyone. This can have an effect on which real estate agents we evaluation and start talk about , but it not necessarily has an effect on one of our guidelines or perhaps help, which are seated in a huge number of hours of investigation. One of our match can not shell out all of us to ensure the good accounts of the company’s products or services. We presume everyone ought to reach help to make financial selections with have confidence in.\nLooking for Medical insurance?\nAfter you’ve carried out the actual study, you may then decide on some other guarantee which can conserve and its particular loved ones. It will always be better to put on as much as medical health insurance as you can, specially if referring in a fair costs. We now have some other level guidelines your best appeal to you.\nAre they Government To have A couple of Medical insurance Procedures?\nFinding the right health care insurance design with a wide variety of wellbeing confidence solutions will get sophisticated of numerous… Your well being awareness assistance what you need to as much as both techniques which it might report a new loss in the accurate buy. My personal advice should be to inform any college health key your you might have college guarantee along with your the parent peace of mind and appearance both of them confidence greeting card. We have been pretty sure they speak about this example comparatively often. Check out a dexterity of advantages provision in both policies.\nAny EPO arrangement employs choose support systems and begin employs plans the motivate and begin manage membership treatment. Nonetheless, a PPO tactics posting increased potential using a large amount of attending doctors. Whether or not double reporting is maintained, and initiate possibly techniques put on necessary deductibles it is paid previously is the winner behave, possibly will need to be satisfied formerly sometimes code will in reality payout. Young adults under the age of 25 nevertheless integrated underneath your ex parent’utes arrangement, even though the girl host to career also offers it health care insurance as a part of the girl full benefits pot.\nThanks for visiting if you’re able to utilize instant medical health insurance in order to obtain the remaining. Continue reading to understand about how to boasts medical insurance in sets of companies. This is probably the most famous variety regarding husbands and wives, whether or not either could possibly get credit reporting from their employers. As you are acquiring a single agreement, this can be the least expensive invention. Maybe, a associate that falls her companys reporting possibly even buy your little bit financial bonus, as they are documenting the business money in not implementing these a companys guarantee. If that’s the case, could you battle paying it does if you necessary to?\nFunction the study on both tactics, discover how much you make payment for you and your girl in order to get on the identical set up and begin kind techniques, or perhaps canceling, optimum from body, and so forth. The most typical how to bunch sight assurance are through an distinct pursuit policy. Your health care insurance code has search confirming, an organization search policy, or even an orthodontic medical insurance bundle. And never getting anyone agreement at key confirming, you should buy groups of wellbeing procedures. It can after soon add up to a major addressing, and you are clearly susceptible to shell out lower good quality amounts when compared if you wish to running a one particular arrangement from better health insurance.", "label": "No"}
{"text": "Pharmaceutical Research jobs in Marketing in Austria4 Results Page 1 of 1\nRefine your search\nCopy Writing/Editing Jobs\nDirect Marketing (CRM) Jobs\nEvents/Promotional Marketing Jobs\nInvestor and Public/Media Relations Jobs\nMarket Research Jobs\nMarketing Communications Jobs\nMarketing Production/Traffic Jobs\nMedia Planning and Buying Jobs\nProduct Management Jobs\nVisual/Display Merchandising Jobs\nICC is a recognized international association connecting cereal scientists and technologists around the world. We are committed to......\nBe part of our team!AT&S is one of the globally leading manufacturers of high-end printed circuit boards and IC substrates and belongs to the......\n\"> 82754-Product Manager (m/f/x) Our Customer is a well-known company and global leader in his industrial sector. High levels of innovation as well......\nAre you interested in joining a dedicated team within a lean organizationOur client is a dynamic privately held Contract Development &......", "label": "No"}
{"text": "The experts at Palo Alto Networks found a brand new Android trojan called TeleRAT. The trojan uses Telegram Bot API for command and control (C&C) server communication and data exfiltration.\nThe TeleRAT trojan is supposed to come from Iran and it attacks Iranian users mostly. According to the researchers, there are some similarities between TeleRAT and another Android trojan called IRRAT, which also leverages Telegram’s bot API for C&C communication.\n“Telegram Bots are special accounts that do not require an additional phone number to setup and are generally used to enrich Telegram chats with content from external services or to get customized notifications and news.” reads the analysis published by PaloAlto networks.\nThe IRRAT trojan can steal contact information, a list of Google accounts registered on the devices, and SMS history. The malware is also able to take pictures with the front-facing and back-facing cameras.\nThe stolen data is kept on a series of files on the phone’s SD card and sent to an upload server after that. Meanwhile, the IRRAT trojan reports to a Telegram bot, hides its icon from the phone’s app menu and runs in the background waiting for further commands.\nThe TeleRAT trojan operates in a different way. It creates two files on the device, telerat2.txt which contains device information (i.e. system bootloader version number, available memory, and a number of processor cores), and thisapk_slm.txt containing a Telegram channel and a list of commands.\nWhen installed onto the system, the malicious code immediately informs hackers on this by sending a message to a Telegram bot via the Telegram bot API with the current date and time. At the same time, the trojan runs a background service which listens for changes made to the clipboard, and then, the application fetches updates from the Telegram bot API every 4.6 second listening for several commands written in Persian.\nTeleRAT is also able to receive commands, to grab contacts, location, app list, or the content of the clipboard; receive charging information; get file list or root file list; download files, create contacts, set wallpaper, receive or send SMS; take photos; receive or make calls; turn phone to silent or loud; turn off the phone screen; delete apps; cause the phone to vibrate; and steal photos from the gallery.\nAdditionally, the TeleRAT malware is capable of uploading exfiltrated data using Telegram’s sendDocument API method in order to evade network-based detection.\nThe trojan can receive updates in two ways – the getUpdates method (which exposes a history of all the commands sent to the bot, including the usernames the commands originated from), and the use of a Webhook (bot updates can be redirected to a HTTPS URL specified by means of a Webhook).\nTeleRAT is distributed via seemingly legitimate applications in third-party Android app stores and also via both legitimate and nefarious Iranian Telegram channels. According to PaloAlto Networks, a total of 2,293 users have already been infected, most of them having Iranian phone numbers.", "label": "No"}
{"text": "In a world where cohabitating and one-night stands are the norm, KimYe was a beacon of hope that pursuing marriage and family could be fashionable again.\nTrue relationships are built on complementarity, not on a product built to serve one’s desires. That’s why it’s impossible to date robots.\nYou’ve probably been asking yourself the same thing I have: ‘What can an ordinary dissenter like me do to save this republic?’ My answer is: ‘Anything I can to fortify myself and others.’\nAs a man, you must be both high-quality relationship material and as attractive as you can be. Here’s how.\nMask scolds have been monomaniacal about this virus as if there is no other way to die. What they don’t seem to understand is that this is no way to live.\nIf we’re inclined to glide past the Marxist fingerprints all over America’s current turmoil, assuming its ideas will flare up for a while and then burn out, we’re not paying attention.\nCollege assignments are meant to gauge learning. Making classes ‘virtual’ decreases the likelihood that learning will actually occur.\nFormer football star Jay Cutler and his reality star wife of almost seven years, Kristin Cavallari, have filed for divorce.\nNetflix’s new reality dating competitions, ‘Love Is Blind’ and ‘Too Hot to Handle,’ have more in common than genre. Their plot twists are sexless.\nThe concept of quaratine dating eliminates one very important variable: physical intimacy. That allows couples to get to know each other before getting physically intimate.\nWorking from home can be fun, productive, and exciting. But it is up to you to make the most of it.\nThat’s the missing element in the push for the so-called equal marriage. By suggesting men and women are essentially the same, we set them up to fail.\nIn a way, I lost everything. But in a more important way, I discovered a purpose I never would have otherwise considered.\nDespite the struggle monogamy may be for many couples, human beings and cultures thrive more in the absence of polyamory.\nA total focus on ‘self-partnering’ sounds self-absorbed. It’s millennials’ latest instance of making our society more atomized and individualistic, to the exclusion of the communal.\nThis Modern Love episode reveals not only deep truths about the lasting pain of father absence, but also highlights the roots of society’s Me Too problems.\n- NFL Legend Brett Favre Slams Woke Sports Leagues And Athletes Kneeling: ‘It’s A Shame’\"Something’s got to unite us. And the games or sport continue reading >\n- The Left Claims Tucker Carlson Is A White Supremacist For Quoting Their Plans For Crushing Republican Voters Through AmnestyLeftist think tanks, journalists, and Democratic politicontinue reading >\n- These Lawsuits Reveal The Left’s Goal To Banish Religion AltogetherLeftists use lawsuits, not to address actual discriminacontinue reading >", "label": "No"}
{"text": "Miracle Mile Advisors LLC purchased a new position in shares of Docusign Inc (NASDAQ:DOCU) during the first quarter, according to the company in its most recent disclosure with the Securities & Exchange Commission. The firm purchased 75,925 shares of the company’s stock, valued at approximately $3,936,000.\nOther large investors also recently bought and sold shares of the company. Sonora Investment Management LLC purchased a new position in shares of Docusign in the 1st quarter valued at $31,000. Clean Yield Group purchased a new position in shares of Docusign in the 1st quarter valued at $31,000. Private Capital Group LLC raised its stake in shares of Docusign by 173.0% in the 4th quarter. Private Capital Group LLC now owns 819 shares of the company’s stock valued at $33,000 after acquiring an additional 519 shares during the period. Parallel Advisors LLC raised its stake in shares of Docusign by 244.1% in the 4th quarter. Parallel Advisors LLC now owns 905 shares of the company’s stock valued at $36,000 after acquiring an additional 642 shares during the period. Finally, Caz Investments LP raised its stake in shares of Docusign by 86.6% in the 4th quarter. Caz Investments LP now owns 933 shares of the company’s stock valued at $37,000 after acquiring an additional 433 shares during the period. 53.08% of the stock is currently owned by institutional investors.\nA number of equities research analysts recently weighed in on DOCU shares. Deutsche Bank raised shares of Docusign from a “hold” rating to a “buy” rating and raised their price target for the company from $50.00 to $65.00 in a report on Tuesday, February 12th. KeyCorp started coverage on shares of Docusign in a report on Monday, January 28th. They set an “overweight” rating and a $59.00 price target for the company. Zacks Investment Research raised shares of Docusign from a “sell” rating to a “hold” rating in a report on Thursday, January 31st. Piper Jaffray Companies raised their price target on shares of Docusign from $50.00 to $61.00 and gave the company an “overweight” rating in a report on Monday, March 11th. Finally, ValuEngine lowered shares of Docusign from a “strong-buy” rating to a “buy” rating in a report on Wednesday, May 8th. Five investment analysts have rated the stock with a hold rating and nine have issued a buy rating to the company’s stock. Docusign presently has an average rating of “Buy” and an average price target of $61.75.\nDOCU opened at $54.46 on Friday. The firm has a market cap of $9.49 billion and a P/E ratio of -18.77. Docusign Inc has a twelve month low of $35.06 and a twelve month high of $68.35. The company has a quick ratio of 1.91, a current ratio of 1.91 and a debt-to-equity ratio of 0.71.\nDocusign (NASDAQ:DOCU) last released its quarterly earnings results on Thursday, March 14th. The company reported ($0.24) earnings per share for the quarter, missing the Zacks’ consensus estimate of ($0.23) by ($0.01). The firm had revenue of $199.73 million for the quarter, compared to analyst estimates of $193.63 million. Docusign had a negative net margin of 60.84% and a negative return on equity of 86.06%. The firm’s revenue for the quarter was up 34.2% on a year-over-year basis. Equities analysts forecast that Docusign Inc will post -1 earnings per share for the current year.\nIn other Docusign news, COO Scott V. Olrich sold 10,000 shares of the firm’s stock in a transaction on Wednesday, May 8th. The shares were sold at an average price of $53.39, for a total transaction of $533,900.00. The sale was disclosed in a document filed with the Securities & Exchange Commission, which can be accessed through this link. Also, CRO Loren Alhadeff sold 8,717 shares of the firm’s stock in a transaction on Tuesday, March 19th. The stock was sold at an average price of $56.04, for a total transaction of $488,500.68. The disclosure for this sale can be found here. Over the last three months, insiders have sold 40,883 shares of company stock valued at $2,212,890. 13.60% of the stock is owned by company insiders.\nCOPYRIGHT VIOLATION NOTICE: This story was published by Stock Observer and is the sole property of of Stock Observer. If you are accessing this story on another publication, it was copied illegally and reposted in violation of US and international copyright and trademark law. The correct version of this story can be accessed at https://www.thestockobserver.com/2019/05/17/miracle-mile-advisors-llc-takes-3-94-million-position-in-docusign-inc-docu.html.\nDocusign Company Profile\nDocuSign, Inc provides cloud based software in the United States. The company offers e-signature solution that enables businesses to digitally prepare, execute, and act on agreements. The company sells its products through direct, partner-assisted, and Web-based sales. It serves enterprise businesses, commercial businesses, and small businesses, such as professionals, sole proprietorships and individuals.\nRecommended Story: Market Capitalization – What it Means for Investors\nWant to see what other hedge funds are holding DOCU? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Docusign Inc (NASDAQ:DOCU).\nReceive News & Ratings for Docusign Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Docusign and related companies with MarketBeat.com's FREE daily email newsletter.", "label": "No"}
{"text": "Single Status Update\nThe one I got though, says she is a L-bian, she was gonna stay with her other \"friend\" in Brooklyn, coming from another \"friend\" in the Bx. She seemed so unhappy, but she asked me alot of questions, even if i lived alone, do I have kids, do I want kids. She wasn't a butch. I don't know if she is Bi, or was just lying to see what i would say, or do. Maybe she said it cause she was tired.", "label": "No"}
{"text": "1. What are your turn-ons?\nconfidence and self-respect, sense of humor and wit, generosity\n2. What are your turn-offs?\nbad breath, arrogance, being mean, being close minded\n3. Not counting your turn-ons, what’s the best trait a person can have?\ntaking responsibility for your own actions\n4. Not counting your turn-offs, what’s the worst trait a person can have\npeople who put others down to make themselves feel better\n5. What’s your biggest pet peeve? loud chewers, people who dominate conversations\nThis content is published under the Attribution-Noncommercial-No Derivative Works 3.0 Unported license.\n2 Responses to TMI Tuesday", "label": "No"}
{"text": "Toll free order line. This jig does not appear to do the same.\nSommerfeld Tools Router Table Finewoodworking\nBoring Tool For Sale Only 2 Left At 65\nPortable Boring Jig Woodworking Network\nOne thing i really like about most of the rest of sommerfelds tools is that they tend to be set once and then repeat many times.\nSommerfeld tools easy bore. Sommerfelds easy bore hinge boring jig full size yellow black. Unfollow sommerfeld tools sommerfelds easy bore hinge boring jig to stop getting updates on your ebay feed. The easy bore hinge boring jig takes all the guesswork out of the aligning and drilling the holes for european style cup hinges.\nFind many great new used options and get the best deals for sommerfelds easy bore hinge boring jig full size yellow black at the best online prices at ebay. Or add to wish list add to compare 3 reviews write a review. Free shipping for many products.\nBut i was pleasantly surprised with sommerfeld tools easy bore jig. Im not the biggest fan of 35mm boring jigs because that size of hole is better suited for a dedicated machine or drill press. I simply selected the adjustable spacing bumpers inside the jig for the correct offset from the stile edge placed the jig onto the door and locked it in place.\nIt features an offset adjustable clamp on frame with spring loaded bits two 8mm one 35mm pre set for the proper spacing. Sommerfelds easy bore hinge boring jig. 1 888 228 9268 sommerfelds tools for wood.\n0 results for sommerfeld tools sommerfelds easy bore hinge boring jig save sommerfeld tools sommerfelds easy bore hinge boring jig to get email alerts and updates on your ebay feed. Most of the products on this website were designed by marc sommerfeld to be better than the alternatives. Sommerfelds tools for wood is a small company that prides itself on high quality products great customer service and industry leading innovation.\nDescription reviews 3 our hand clamped boring jig drills a 35mm hole and two aligning 8mm holes at the same setting which allows you to accurately install your. The best way to position these holes properly is to use sommerfelds easy bore hinge boring jig item.\nSommerfeld S Professional Cabinetmaking System\nSommerfeld S 3 In 1 Pocket Cutter\nGeneral Tools Ez Pro Deluxe Pocket Hole Jig Kit 850 The Home Depot", "label": "No"}
{"text": "Help us make a difference\nYour support can make a lasting impact in the lives of the animals we care for. As a registered 501(c)3 non-profit organization, we rely on the generosity of compassionate individuals like you to continue our vital work.\nBy making a monetary donation, you contribute directly to providing shelter, food, medical care, and love to the animals in our care. Every dollar counts and helps us make a difference. Join us in our mission to create a brighter future for these deserving animals by making a donation today. Together, we can give them the second chance they deserve.\nYou can also support our mission by generously donating wishlist items to further our cause:\nAny brand of clumping cat litter\nPurina One Kitten dry cat food\nPurine One Kitten canned cat food\nPurina One dry adult food\nPlastic/Washable cat toys\nCatego Fast-Acting Flea & Tick Treatment For Cats/Kittens\nCollars & Leashes\nGarbage Bags – any size\nNatures Miracles Cleaners\nScotchbrite Scrubbing Pads\nHE Laundry Detergent - Unscented\nLitter Pans – any size\nStainless Steel Water & Food Bowls\nSmall Fleece Blankets\nEmpties for Animals\nIf you've got returnable cans & bottles piling up - why not clear out the garage AND help the animals! Just stop by our building anytime and drop your bagged empties into one of the brown bins at the side of the building.\nAt Second Chance Animal Shelter, we recognize that our mission to improve the lives of animals would not be possible without the invaluable support of our sponsors. Their unwavering dedication and generosity have been instrumental in helping us fulfill our commitment to rescuing, rehabilitating, and rehoming domestic animals in need.\nIt is through their contributions that we are able to provide vital medical care, nourishment, and a safe haven for these animals. We extend our heartfelt gratitude to our sponsors for their continuous support and belief in our cause. Their commitment to our organization strengthens our ability to make a meaningful difference in the lives of countless animals, and we are truly grateful for their partnership in creating a brighter future for these deserving creatures.\nBecome a Sponsor\nWe are asking you to join and support Second Chance Animal Shelter by investing in a naming opportunity in memory of a beloved pet or family member or providing a living legacy for yourself or your business/organization.\nA permanent naming investment is a beautiful way to help homeless pets get their second chance at life. You will be providing shelter, medical care and a comforting environment until they are placed in their forever home. Please contact us to discuss opportunities available.\nThank you to those that have chosen to join us in giving the animals their second chance:\nDavid J. Zolnierek Inc.\nGone to the Snow Dogs & The Pawdience\nSteve & Gayle Torhan\nIn Memory of Mia\nLeanne, Fred & Olivia Bloom\nDan & Rachel Savage / Roxann Eberlein\nHuron Veterinary Clinic\nIn Memory of Kimberly Blaski Bates", "label": "No"}
{"text": "On October 24 and 25, BIOS introduced 42 primary and middle school teachers to a suite of education opportunities being offered through the Institute’s Mid-Atlantic Robotics IN Education (MARINE) program. The MARINE program workshops were coordinated through the annual Bermuda Union of Teachers conference, which includes professional development opportunities for teachers in the Bermuda Public School system during the fall half-term break.\n“In addition to science, technology, engineering, and mathematics training, MARINE provides half-day field trips and virtual lessons that explore topics in robotics, physics, and computer science,” said Kaitlin Noyes, BIOS director of education and community engagement. “Thanks to the generous support of our donors, we have funding available to support up to two MARINE lessons per class during the 2022 to 2023 school year.” This funding covers the cost of transportation on the BIOS bus for in-person excursions at the Institute, experimental materials, and a BIOS educator.\nThe hands-on workshops were designed to introduce educators to the three MARINE programs and provide insight into how the lessons relate to Cambridge International Curriculum objectives, as well as ongoing research taking place at BIOS. The programs being offered for the current academic year include: “Diagrams and Conductors (Circuits),” “Simulations,” and “Robotics.”\nEach two-hour professional development workshop featured three rotating stations at which teachers could spent 30 minutes engaged in activities related to the programs, some of which include both field excursion and virtual options. Claire Fox, BIOS education officer, led teachers through a circuit building experiment linked to the “Diagrams and Conductors” program that was centered around testing conductors and insulators.\nChloé Baron, a Bermudian software developer, worked with teachers on a session supporting the “Simulations” program. She introduced participants to the concept of how digital prototypes can be utilized in computer simulations to help test and gather feedback for improving the design of underwater robots called remotely operated vehicles, or ROVs. Baron shared that ROVs are being used locally to help control the invasive lionfish population and led teachers through a computer-based ROV simulation focused on the crown-of-thorns starfish, whose population outbreaks can cause damage to Indo-Pacific reefs.\n“The teachers dove right into the simulation and began proposing design solutions for their own ROVs,” Baron said. “Even though the simulation focused on a species not found in Bermuda, it was engaging and got them thinking about factors that need to be considered in ROV design, such as electrical current, storage capacity, and buoyancy. It was hard to pull them away from the computers at the end!”\nFollowing the ROV simulation, teachers headed to the BIOS Innovation Pool to meet Kyla Smith, dive safety officer, and Kwe’Shon Woods-Hollis, small boats and docks supervisor. In a session that connected to both the “Circuits” and “Robotics” programs, Smith and Woods-Hollis showed teachers how to pilot ROVs to catch “lionfish.” Teachers also discussed the circuits used in the ROVs and brainstormed ideas for improving the robots’ overall design to be more efficient tools for culling lionfish.\nAfter attending the workshop, Denise Booth, a primary 6 (U.S. grade 5) teacher at West Pembroke Primary, booked her class for a “Circuits” program at BIOS on November 29th and 30th. Over the course of two days, her students will participate in the same sessions she tested during the professional development workshop in October.\n“I knew immediately that BIOS was the place my students needed to visit to learn about circuits, as the hands-on activities are perfect for the P6 level,” Booth said. “I had an amazing time engaging with circuits and robotics. I didn’t know that ‘Play-Doh’ was a conductor of electricity!”\n“The teachers enjoyed exploring novel ways to reinforce aspects of the physics curriculum that they deliver at school and I think they will be very involved when they bring their students to participate in these field trips at BIOS,” Fox said. “I found it really helpful to work not just with science teachers, but teachers of all subjects, as we had some great discussions about cross-curricular learning.”", "label": "No"}
{"text": "Miracle Noodle - Miracle Ready to Eat - Japanese Curry, 10ozBrand - Miracle Noodle\nQuick DescriptionTantalize your taste buds with the sweet and umami taste of Japanese Curry. With Miracle Noodle’s Miracle Ready to Eat Japanese Curry, you’ll have the best quality ingredients without the extra calories. What’s more, preparing your meals will take only minutes with this ready-to-eat pack.\nIngredients: Konjac Shirataki Noodles (Water, Konjac Flour, Limewater [water, Calcium Hydroxide]), Carrot, Onion, Coconut Sugar, Tomato, Apple, Coconut Oil, Gluten Free Soy Sauce (Water, Soybean, Rice, Salt), Ginger, Garlic, Curry Powder (Turmeric, Coriander Seeds, Clove, Nutmeg, Star Anise, Salt), Salt, Lactic Acid, Black Pepper, Bay Leaf.\nShopping Cart Continue Shopping\nYour cart is currently empty.\nYou have items in your order that need to be refrigerated during delivery. In order to ensure that these products remain fresh, we must ship them to you as quickly as possible. Make sure to refrigerate or freeze immediately upon arrival. All refrigerated items must be shipped via FedEx 2 day shipping, and will only ship out Monday-Wednesday each week. If you order after 12pm est on Wednesday, your order will ship the following week. If you would like to avoid this extra shipping and refrigeration charge, please remove the refrigerated items from your cart.× Remove Refrigerated Items", "label": "No"}
{"text": "By NEESEY PAYNE\n“In public education, if you’re a teacher there are very few things that you have that really present job security. This is one that gives just that little sense of security and I am very glad to support it,” said Pulaski County School Board member Linda Hill in response to a resolution supporting the continuing contract at a session of Pulaski County School Board.\nAccording to information presented during the session, the General Assembly adopted continuing contract laws in 1968 to establish uniform employment practices, define causes for teacher dismissal and provide employment security after a three-year probationary period.\n“The resolution outlines support for continuing contract laws and opposes removing continuing contract protections from Virginia public school teachers,” said Dr. Thomas Brewster, superintendent.\nThe resolution states:\nContinuing contract laws benefit public school students, their parents, the community and the Commonwealth by:\n• Assuring the high-quality educational program and curriculum set by the local school board in compliance with the Standards of Quality is delivered by competent professional teachers.\n• Attracting talented individuals to secure professional employment.\n• Retaining high-quality professional teachers while minimizing expenses caused by high turnover.\n• Assuring stable and consistent instruction provided by professional teachers not subject to arbitrary dismissal.\n• Fostering professional experience and subject understanding with teachers protected from replacement based on cost.\n• Assuring professional teachers uphold high academic and behavior standards.\n• Assuring school administrators and managers conduct professional teacher assessment and evaluation.\n• Assuring nepotism or political favoritism do not influence teacher employment and school instruction.\nThe board voiced unanimous support for the resolution.", "label": "No"}
{"text": "|A Colorful Elk River Hatchery Brat|\nThe Caney Fork- water releases have been 24-7 at 10,000+ CFS. It becomes more and more tempting to get out there and just see what, if anything, is happening. So I still suggest not getting on the river while continuing to fight the urge.\nThe Obey had some windows of 1600+ CFS, which is a decent flow for floating. It isn't the best but it is doable. Wading has been non-existent so far on the Obey this Winter. Hopefully the weather and generation will cooperate in the very near future.", "label": "No"}
{"text": "August 22, 2019A Sad and Sudden Loss for CCF – Eulogy for Romeo\nMarch 12, 2019Eulogy for “Scientist” Fossey\nOctober 4, 2018Cheetah and Livestock Guarding Dog Update\nJune 7, 2018Cheetah Update – Dominic is Two Months Old!\nApril 25, 2018Update on Resident Cheetah Solo\nFebruary 12, 2018New Arrivals at CCF", "label": "No"}
{"text": "Reliable. Validated. Compact. New state-of-the-art ELISA microplate reader with latest LED technology The Infinite F50 is Tecan’s next-generation, 8-channel absorbance microplate reader that provides accurate, reproducible and fast measurements out of a compact, innovative design. With Magellan™, comprehensive reader control and data analysis software, the Infinite F50 is ideal for a variety of ELISA applications. • 8-channel absorbance microplate reader for fast measurements • long-life LED for maintenance-free operation • outstanding reliability proven by unique benchmark value (MTFF**) • Magellan reader control and data analysis software for quick and easy measurements and powerful data reduction • endpoint, kinetic and multi-label measurements for a variety of applications • wizard-ba...Read more\nReceive your quote directly from Tecan.\nSelectScience Members can achieve membership status by writing product reviews. This helps other members to better understand the Reviewer's experience and expertise.\nStatus: No. Reviews Published: Member 0 1-4 5-14 15+ By Invitation\nReviewers are also encouraged to publish a 'public profile' so others can benefit from a further understanding of the Reviewer's applications and expertise.\nWrite a review today>>\nReviewer(what's this)Membership Status\nMember since: 2013\nOrganization: University of New Orleans", "label": "No"}
{"text": "Lancashire and Cheshire Amateur League, Division Two\nMoston United 1 Swinton 4 (att 20)\nI picked this game as the 3pm kick off allowed me to watch Leicester (the team I support from my armchair) away at Stoke on TV, and still get a new ground, not something I can do very often.\nMoston United are new team this season, and appear to have some connection with FC United of Manchester. They play in FC United kit, and their home ground is the 3G pitch next to the Broadhurst Park stadium.\nThey have a young side, and having started the season well I expected them to see off visitors Swinton, but the result turned out to be something of a surprise.\nThe visitors went ahead thanks to a penalty, and got a second before half time when a free kick was misjudged by the Moston keeper who allowed it to creep in at his far post.\nMoston pulled a goal back in the opening minute of the second half, but if they thought - as I did - that it'd be a springboard to get back into the game, they were wrong. Swinton responded by quickly adding a third, and a late fourth goal gave them a resounding win.\nThe 3G pitch at FC United is exactly as you'd expect this sort of ground to be. It's floodlit, thus making 3pm kick off possible in November, and enclosed by a high fence.", "label": "No"}
{"text": "Since we started in business 18 years ago the market has evolved significantly\nand so has our business. Initially we sold rear projection systems, now\nwe distribute a stable of AV brands focussed on\nHerma owns and produces products under the LP Morgan, Grandview and 2C labels. Complementing our local brands we distribute several innovative AV visual solutions exclusively in Australasia.\nFrom our 2000m2 warehouse, office and manufacturing facility in Preston we handle logistics, brand management, channel management and after sales support. Herma stocks volume products available for off the shelf shipping as well as being able to manufacture custom projection tailored to your needs.\n|We care about your image\nWe know our range needs to keep up with your ever changing requirements. That’s why so much of the product in our new released 2011/12 catalogue is new. Have a look at the ever expanding Grandview range. New screen sizes, new screen products, more choice, and new projector mounting solutions.\nThere’s a larger range of Club Lounge seating from LP Morgan, and new CineTheatre screen products. Panamorph, SunBrite TV and Brightline all have great new items in their ranges too.", "label": "No"}
{"text": "Just one month ago, April 30th, we had a total of 9 visitors to RunPee.com. Since then the traffic has skyrocketed. Our low traffic since we were noticed is just over 6,000+ daily visitors. In that time we’ve had two server crashes, a move to a new more robust/costly server and a half dozen traffic spikes that left the site crawling…but not down for the count.\nThe number that is the most amazing to me is: traffic is incoming from 2,541 different sources. I want to say a big thanks to everyone who posted about my site here. Never in my wildest dreams did I see this coming.\nNow, next week I’m being interviewed by Robert Kovacik from KNBC here in LA. I’m not sure when it will air but I’m sure it will lead to another server crash. I try to look at is as a good thing. 🙂\nThe World's Most Indispensable Movie App\nRead more about the RunPee app.\nThe iPhone app is coming!\nThe team building the iPhone app isn’t far enough along yet for me to give a precise release date but it will be measured in weeks I assure you. Most of it will be up to Apple and when they decide to let it pass onto the App Store. I’ll certainly get the message out as soon as it’s available.\nBut an iPhone app is useless if there aren’t enough high quality RunPeeTimes. To that end I am going to add features that will moderate the RunPeeTimes that you see so that we don’t get any of those of the “Just pee and then go home” variety. Plus you will be able to vote on the RunPeeTimes that you do see. So don’t forget to come back to the website after you see a movie and let others know which RunPeeTime you thought was the best to use. Remember, bladders are counting on you! 🙂\nThese new features will be in place when the iPhone app launches. Until then I’ll just have to clean up the RunPeeTimes the good old fashioned way, through the MySQL web interface. 🙁\nDon’t miss your favorite movie moments because you have to pee or need a snack. Use the RunPee app (Androidor iPhone) when you go to the movies. We have Peetimes for all wide release films every week, including Guardians of the Galaxy: Volume III, Super Mario Bros. Movie, and coming soon Fast X, and The Little Mermaid 2023. We have literally thousands of Peetimes—from classic movies through today's blockbusters. You can also keep up with movie news and reviews on our blog, or by following us on Twitter @RunPee. If there's a new film out there, we've got your bladder covered.\nCreator and developer of the RunPee app. When something doesn’t work right in the app it’s pretty much his fault. 🙂\nAspiring author. Would like to finish his “Zombie Revelations” trilogy if he could break away for working on RunPee and the cottage he’s building for RunPee Mom.\nJoin the conversation\nhttp://www.RunPee.com for all movie ‘goers’ :)~\nfor WHEN you have to GO…RunPee\nmakes it OK to order a drink at the movie.\nI read your interview on my daughter’s website – Nicole Dean – clicked on and laughed my butt off! I LOVE your sense of humor and reality! I am currently in the process of getting my own blog – Remarkable Wrinklies – monetized with the help of my brilliant and talented daughter’s help. “Remarkable Wrinklies” is the perfect place to hype your site! I’ll be doing so with gusto asap! The site is primarily for and about remarkable people doing remarkable things as we become “wrinklies.” Focus group 50+ so you know we gotta pee! Thanks for the informative and entertaining website. I will be sure to click on next time I go to the movies! Thank you! 🙂\n@Patti, thanks so much. Yes, I have definitely noticed that as I get older I can’t hold it as long. Best of fortune to you with your new blog. Pop back here and comment all you want. The links will always be ‘do follow’ so you’ll be getting a link back to your blog when you post here.\n@polyGeek: I’ll go yell at the guys at @DeafCode to get shakin’ (not like Pee Wee Herman!) to get a RunPee button in CaptionFish.com results. As soon as they do, I’ll update The Telegraph Hearing Blog entry on your services, which will push the post to the top of the pile again.\nRunPee on CaptionFish: Because deaf people pee just the rest of you!\n@Hi_Dan on Twitter\nYour host of The Telegraph Hearing Blog (London)\n@Dan Schwartz, Thanks! You’re right. We all need to pee.\nFunny Tweet addressed to me from @BarackBorat\n@BarackBorat: @Dan_Schwartz I am most definite talk to @RunPee. Save bladder during long MovieFilm is biggest Kazakh public health advance!\nHave you written Web services for Run Pee. I would like to write a windows Mobile application for it. I just need to get the list of movies the list of pee times length of the pee and the text that says what you are missing. I wanted to write the IPhone App but I see you are. That should make you some money to pay for those tires.\n@Dave, There will certainly be a Windows mobile app. As I’ve learned in the past few weeks the problem is that if there is a public API then how do I make any money off of it? Because the website itself will probably never make all that much since the most compelling use-case is mobile.\nI think Iphone is the best story for making money. People with Iphones or Itouch can download the app for a buck from the app store the great thing is 1000’s will do it. It’s less likely for the folks with Smart Phones and Black Berries since it’s not as easy and a different demographic. However I can’t fault your logic. Looking forward to the Windows mobile version. Good Luck.\n@Dave, thanks. I agree. I think the iPhone version will be a good seller. I’m hopeful that the Blackberry will be as well. And I think Blackberries have outsold iPhones over the past few years. So while the Blackberry demographic may not be as inclined to buy the app there are more of them. Time will tell.", "label": "No"}
{"text": "Jun 7th, 2017\nWales to host The Open?\nNot according to the R&A...\nWords: Tim Southwell Photography: Getty Images\nThere have been 145 Open Championships in England, Scotland and Northern Ireland. But never in Wales. The R&A have stated they have no intention of holding an Open in Wales. But is that the end of it?\nRoyal Porthcawl might need some development to get 'Open ready' but it's a magnificent golf course, very popular with tour pros and amateurs alike, and has hosted significant events in recent years including Walker Cup, British Seniors Open (2104) and the Amateur Championship (2016)\nWales sporting officials are hoping they can persuade the R&A to break from tradition and try something new.\n\"There are opportunities to host more golfing events and I'm keen to discuss with the R&A the potential of Wales to host the British Open,\" said Economy Minster Ken Skates.\n\"I think it is right that if we call it a British Open that it should be hosted in Wales and I'm to keen to make sure that discussions take place with the R&A on that.\n\"I'll be meeting with The R&A again this summer to discuss how we take forward the potential of a British Open being staged in Wales. I think it is our time,\" he said.\nRoyal Porthcawl attracted 43,000 spectators to the 2014 Seniors Open but would need extensive development to host an event of the magnitude of The Open, which packed in about 175,000 fans at Royal Troon in Ayrshire last year and is expected to host over 200,000 fans at Birkdale in a few weeks.\nRoads leading to the course are narrow and residential, while local public transport could struggle to cater for the huge crowds that Open Championships attract. But nothing that some good old fashioned planning, blood, sweat and tears couldn't overcome.\nThe R&A has previously said that said it had \"no intention\" of hosting the competition in Wales, which until 2014 hosted an annual Wales Open tournament at Celtic Manor in Newport.\nThe Open venues are confirmed until 2020, but Wales, and Porthcawl in particular are waiting in the wings.\nNext four Open venues:\n- 2017 -- Royal Birkdale Golf Club\n- 2018 -- Carnoustie\n- 2019 -- Royal Portrush Golf Club\n- 2020 -- Royal St. George's", "label": "No"}
{"text": "NTT Communications Corporation has launched NTT SD-WAN Service Portfolio, the world’s first SD-WAN platform with coverage spanning over 190 countries.\nIn another first, NTT Com sets a new industry benchmark by becoming the world’s first global provider to deploy a 100 percent software defined network that provides the framework for NTT Com to offer a rich suite of overlay SD-WAN services for global and regional enterprises, along with industry leading SD-WAN network performance for enterprises and end-users.\nThe global software defined network provides NTT Com with unprecedented flexibility and speed to launch new services designed to assist enterprises in transforming their businesses and responding to their competition. NTT Com is expanding its Software-Defined Network Service and now has more choices to offer customers by launching these SD-WAN services.\nNTT SD-WAN platform is based on a groundbreaking architecture that is locally distributed around the world via 75+ local cloud centers (LCCs), optimized for network, mobility, and security services. NTT SD-WAN real-time streaming network analytics offers CIOs and their IT staff deep insight into application performance, network security, and the end-user experience. The platform also supports the delivery of services from customer premises equipment located at customer branch offices.\n“Digital transformation is at the heart of every modern enterprise today, fundamentally changing companies’ business models,” said Mr. Shuichi Sasakura, Senior Vice President Network Services of NTT Com. “The global NTT SD-WAN Service Portfolio is an end-to-end solution that provides organizations with a highly flexible and agile network that is fully tailored to their specific requirements and enables them to better compete in today’s digital economy.”\nNTT Com is leveraging software defined technology and platform acquired via the Virtela acquisition in 2014. Virtela, a leader in software defined networking, was offering software defined network services to enterprises for over 12 years at the time of acquisition. Together, the NTT Com and Virtela teams continue to accelerate the development of NTT Com’s “SDx+M Solution Strategy.”\n“NTT SD-WAN Service Portfolio is backed by our employees’ unmatched passion for customer support,” says Ron Haigh, President of Virtela, NTT Com’s global enterprise network business unit. “NTT Com would like to thank our customers, partners, and employees for helping us achieve this software defined networking industry milestone.”\n“We’ve leveraged NTT Com services as part of Dimension Data’s Managed Hybrid WAN solution for numerous customers with great success,” says Rob Lopez, Group Executive Networking, Dimension Data, an NTT Group Company. “We’re excited by the enhancements that NTT Com has made to its SD-WAN portfolio, and we look forward to working together to bolster the value we offer our joint customers.”\n“CIOs are increasingly interested in software defined networking technology. NTT DATA is a frontrunner in offering innovative solutions and is looking forward to helping clients take advantage of NTT’s SD-WAN Service Portfolio,” says Marv Mouchawar, President, Strategic Business Units, NTT DATA, an NTT Group Company.\n“Inteva’s business is dependent on our network performance and NTT’s global SD-WAN network services provide us with high network reliability and performance. NTT Com’s customer support team is highly proactive and responsive which allows us to focus on running our core business,” says Dennis Hodges, CIO, Inteva Products, LCC.\n“NTT Com is raising the bar in the telecom industry by reaching a global, 100 percent software defined network milestone and in offering a ubiquitous overlay of SD-WAN network, application acceleration, and security services for enterprises around the globe,” states Michael Suby, Stratecast VP of Research at Frost & Sullivan. “Among the most innovative and globally flexible solutions available in the market today, NTT’s SD-WAN Service Portfolio delivers the reach, performance, and adaptability organizations need to meet today’s business demands and transform their enterprise networks.", "label": "No"}
{"text": "May I have your attention please!\nAwareness has come up for me several times in the past week, both others and my own. My daughter asked me to talk to both my grandchildren at separate times, and while the discussion was about a specific issue, they both came down to awareness.\nAs children, we begin to be conscious of ourselves as separate beings starting at about 18 months, and self-awareness needs to be nurtured throughout their lives. But that does not mean they are necessarily aware of their specific actions and definitely not aware of cause and effect; that comes much later.\nOne of the issues I have discovered that I did not do with my daughter and, therefore, she does not do with her children is to teach awareness. Children mostly live in the moment; if something looks, tastes, or feels good, children jump right in without any thought whatsoever.\nMy grandchildren are seven and four, so the older one is just at the age to begin to contemplate the results of her action, which includes increasing her awareness of the present moment. An example of this lack of awareness in children, teenagers, and adults are repetitive tasks.\nAs with everything in life, this works both to our advantage and disadvantage. For example, we rarely think about walking after two years old because we have mastered stepping forward. However, if we reach a step or steep hill, our awareness returns immediately.\nSpecific actions need our attention every minute, such as using a table saw; while walking is safer with time, table saws do not get safer with each cut! Two activities involving awareness jump out at me for children, crossing the street and closing a car door.\nBoth my grandchildren can now unbuckle their seat belts, open the car door, climb out, and shut the door. Most of us adults know this is normal learning behavior, but we do not remember how heavy a car door is for a child. Parents might say something like, “Be careful,” but we do not teach being aware.\nWe need to talk with our children about how they approach closing the door, get them to acknowledge how heavy it is, and ask what they think would happen if they closed the door on their thumb or finger. And then, as with all teaching, repeat the lesson several times a week when they begin to shut the car door, saying, “Be aware of shutting the door.”\nLikewise, crossing the street requires constant repetition, starting when holding hands when they are too young to cross by themselves; repeating out loud, stop, look both ways, and when clear, we can cross. The originator of my style of yoga had a wonderful saying about yoga, which applies to everything in life, “1% theory, 99% practice.” This saying applies when teaching children anything; we need to use persistent repetition!\nThese two examples of awareness teaching are especially true when children (and ourselves!) are apt not to be living in the moment, such as getting out of the car or crossing the street to join friends, going to a game, or getting ice cream. In these moments, when our attention is diverted, we need to learn to stay in the moment and be aware of what we are doing.\nHave not most of our accidents happened precisely in situations like this? So then, as if to bring this subject home for me, after writing several paragraphs, I went to make my evening protein shake, something I have done for years. After adding all the ingredients to the shaker, I went to put the protein powder canister up and knocked over the shaker; water and powder went everywhere!\nAhh, not paying attention to a repetitive task; the Universe has a wicked sense of humor. Obviously, I am still learning, and I had a great laugh! Thankfully, unlike not having awareness with a table saw where an accident can be damaging (I have three customized fingertips to prove this), the spill was a quick cleanup!", "label": "No"}
{"text": "Lateral flow tests have all the hallmarks of a quality diagnostic test.\nFast-acting and versatile, they can be used at the point of care with or without a reader, meaning that they’re easy to use, require little training and are easily deployed in any location.\nThis extraordinary technology is an area where Mologic are continuing to make huge advances.\nSpeaking with Paul Davis, Co-founder and Chief Scientific Officer at Mologic, it was fascinating to hear what he had to say on the next steps for lateral flow. How could we improve this beautifully simple technology?\nFeaturing Synda Clements, Director of Talent Acquisition at ConcertAI.\nTalent scarcity is hard to solve in the current climate, but developing a strategy of substance for attracting top-tier candidates is the ultimate way to stand out and win the right people. Here, I delve into how to do just that.\nIn an ever-changing industry, how can cell and gene therapy start-ups remain dynamic to new challenges to not only survive coming changes but thrive? Click to read more.", "label": "No"}
{"text": "There’s nothing quite like the experience of live music, especially choral music: the power of voices making music together. At our concerts, you’ll hear songs from across the ages: from Medieval polyphony to Baroque splendour; from Romantic choral classics to contemporary music written just this year. As we are an all-female choir of trained voices, the sound could be quite different to what you might expect.\nChristmas at Highcliffe 2020\nWednesday 16 December 2020\nDue to COVID-19, this event has been cancelled for 2020. We hope to return to Highcliffe in 2021.", "label": "No"}
{"text": "The Namibia Economist | August 3, 2020\nSave the Rhino Trust has just received more than one million dollars in funding from the Debmarine-Namdeb Foundation. This diamond money will be used to support physical protection of rhinos in the wild, but also to amplify a reading programme for learners in the Kunene region.\nWhile law enforcement is important as the primary deterrent to poaching, the Trust said it has learned over the years that long-term perceptions of the value of rhinos for local communities, is just as important and provides a more lasting positive impact.\nTo build positive opinions of rhinos among local communities, Save the Rhino Trust is partnering with Mondesa Youth Opportunities, an NGO who helps Kunene learners to develop and improve their reading skills. In this way, many supplementary learning opportunities are provided to the learners. Mondesa Youth covers numerous subjects but an enhanced level of reading ability is specifically promoted to improve general literacy.\nSave the Rhino Trust’s Chief Executive, Simson Uri-Khob said “Both the Trust and Mondesa Youth have blazed new trails in their respective fields and together we seek to address two looming threats to both the rural people and an iconic Namibian treasure such as the black rhino. The donation from the Debmarine-Namdeb Foundation will address low literacy rates among the region’s youth as well as the persistent threat that poaching holds for the region’s globally important black rhino population.”", "label": "No"}
{"text": "Face Swap makes easy and fun to switch faces on a picture\nSimilar app: Face Swap Lite\nSimilar app: Face Swap\nA fun app to swap faces and create funny results\nPhoto editing app which lets you crop from one photo and copy to another\nSimilar app: Cut Paste Photos\nCustomize your photos and become haunted!\nSimilar app: HauntedBooth Pro\nCurious to see how you or your friends would look as a ghost?...\nSimilar app: HauntedBooth\nPoker based puzzle game\nSimilar app: Poker Swap Pro\nSimilar app: Poker Swap\nBecome a hero and attack\nSimilar app: Arena Quest RPG (free)\nSwipe tiles, match aliens, watch them evolve\nSimilar app: Caveboy Escape\nswap your face and share with socail media and enjoy\nSimilar app: Face Swapping\nFace Swap, Like a Boss!\nFace Swap! is the #1 face swapping apps....\nSimilar app: Face Swap!\nOther users also looks for:", "label": "No"}
{"text": "When plants were visited in September 2019, many had no seeds, yet some still had flowers. The first week of September might not be an ideal time to collect.\n|Common Name||Name in Text||Association Type||Source|\nFall fundraising drive has begun! We're looking for 2,500 people to protect our planet. With you by our side, we will build a future where people live in harmony with nature. Come help and become a CPC donor today.Donate Today", "label": "No"}
{"text": "New York Jets\nWith NFL training camp underway, let’s look at the biggest storylines to watch for in camp the next month.\nThere are a good amount of teams this season that will be looking to their quarterbacks to bring everything together to be on the winning path. Here is my list of quarterbacks that need a big 2014 season….\nIn our first list, we took a look at the pump up songs used by athletes Jason Hammel, Zach Johnson, T.Y. Hilton, Saul “Canelo” Alvarez and Swin Cash. In this installment, we’ll deepen our search […]\nRams released the veteran running back on Thursday\nThe complexion of the National Football League changed last Saturday after Michael Sam became the first openly gay player to be drafted.\nTeam reportedly considering the former New York Jet as a backup for Sam Bradford\nResearchers analyzed tweeted reactions in NFL markets to Michael Sam’s announcement that he is gay.\nJets defensive tackle named cbssports.com Defensive Rookie of the Year\nFans in New York never want to abandon thoughts of the postseason this early into any season. As frustrated as they may be, the hope of a postseason run remains in the minds of the fans of both New York NFL teams.\nSt. Louisan & Mizzou alum had 1 sack & 5 tackles, Monday night.", "label": "No"}
{"text": "Gale Lackey Gains Win No. 400 vs. WCSU, Then Cards Win Three More to Take Wes Invite Title\nDirecting the Cardinals to a 3-0 victory over visiting Western Conn., Wed., Sept. 26, Head Coach Gale Lackey notched victory number 400 in her career. Gale is in her 23rd year at Wesleyan with a cumulative mark of 387-307. She came to Wesleyan in 1978 with one year of college volleyball coaching at Bridgeport under her belt, posting a 13-13 record there. She took over the volleyball team at Wesleyan in 1985, the team's second varsity season, after coaching Wesleyan's field hockey squad during the fall for seven seasons. Current NESCAC Player of the Week Lisa Drennan '09 led the charge vs. WCSU with 15 kills and a .542 hitting efficiency. As a team the Cardinals hit at a solid .422 pace. Fotini Xenidis '11 added nine kills while setter Ellie Healy '10 contributed 36 assists. Caroline Rober '08 did her part in the middle with five blocks and libero Ruby Hernandez '11 (#1, photo insert lower left) made 14 digs. Wesleyan gave Coach Lackey win no. 401 in thrilling fashion Fri., Sept. 28, 3-2 over Amherst in the opening round of the 18th annual Wesleyan Invitational. Wesleyan won the final two games, breaking a 6-6 tie with seven consecutive points in the deciding contest for a 15-9 win. Drennan racked up 33 kills, matching her team record, while Hernandez tied the mark of 34 digs in a match set by Tory Molnar vs. Coast Guard in 2003. Xenidis contributed 13 kills, Healy had 59 assists and Ashley Farrow '10 came through with eight blocks. The Cardinals faced Old Westbury and Trinity Sat., Sept. 29 to close out the Invitational, winning both by 3-0 counts to give Wesleyan the title. Xenidis led the way with 16 kills vs. Old Westbury while Emily Dine '09 dished out 30 assists. In downing Trinity, Drennan added an amazing 24 kills with Healy tossing up 37 assists. Both were named to the all-tournament team. For her fine play throughout the week, Hernandez was honored as the NESCAC Player of the Week. At Conn. College Wed., Oct. 3, the Cardinals six-match win streak came to an end in a five-game NESCAC match with the home squad capturing the final game, 15-11. Hernandez posted a team-record 36 digs during the match. Wesleyan concludes the week with another NESCAC match, this one at home vs. Trinity Friday, Oct. 5.", "label": "No"}
{"text": "Columbus has a population of 185,781 and is located in Muscogee county.\nAppliance Repair schools in Columbus charged students an average tuition of $4,747.00 if they were Georgia residents, and $7,521.00 if they were non-residents, during the 2009 - 2010 school year.\nThe cost, on average, for books and supplies needed for appliance repair schools in Columbus is $737.00. Students who live on campus while attending a appliance repair school in Columbus, can expect to pay an average of $8,888.00 for room and board. Students who live at home can expect average costs to be $5,374.00. Students have a choice of one appliance repair college in Columbus to attend. Appliance Repair programs in Columbus reportedly graduated 27 students in the 2008 - 2009 school year.\n|Profession||Average Salary||Number Employed in City|\n|Heating, Air Conditioning, and Refrigeration Mechanics and Installers||$33,520.00||170|", "label": "No"}
{"text": "Queerty is better as a member\nTHE SHOT — Cheyenne Jackson as Jack Baker on 30 Rock, where the gay cruiser will play a new member of the TGS cast and … love interest? Cheynne’s first episode debuts Nov. 12. (via)\nDefinately will watch more!! Tina is the Dorothy Parker of our times…\nIf he’ll be out while he’s on the show, then good for him, sounds like Tina Fey is keeping the show fresh.\nNeed an account? Register It's free and easy.\nYouTuber Asks Mom To Rate His Slutty Halloween Costume Contenders\nLance Bass Says He Was \"Inappropriately Touched\" As A Teenager\nRussell Tovey Live-Tweets \"Flight From Hell\"\nMom Shaves Homophobic Son's Head, Forces Him To Walk Around Wal-Mart In Tutu", "label": "No"}
{"text": "Click to Watch the video below & explore more about OTT Advertising!\nWhy Advertising in IPL on Jio Cinema App – Digital Advertising in IPL 2024 – A Leading OTT Advertising Platform\nAdvertising in IPL on Jio Cinema is one of the best ways to target a massive number of people at a stance. Jio Cinema is India’s leading and one of the most viewed OTT platform By Viacom 18. Now, the local brands of India can also advertise in the IPL 2024 through the Jio Cinema App & can reach millions of local people with the utmost ease. Moreover, the cost of advertising in IPL on Jio Cinema in India is so reasonable & affordable that it has now been entitled to be the best local media in town to opt for advertising your product or service.\nJio Cinema is now the most-watched OTT app due to telecast of IPL 2023 digitally. Jio Cinema App offers Original Web Series, Live Sports, International TV Shows. When it comes to sports, Cricket is the heartbeat of Indians, as it is popularly watched and played in every nook and corner of the country.\nWhy Advertise in Indian Premier League or IPL 2024?\nIPL was started in India by BCCI and from then it has emerged as the most popular T20 league in the world. With Tata Group being the official sponsor and Jio Cinema the official digital broadcast partner of IPL 2024 – The biggest cricket season is coming back again with more entertainment, more action with 10 teams including two new city teams introduced in 2022, i.e. Ahmedabad and Lucknow naming Gujarat Titans and Lucknow Super Giants\nBeing the biggest T20 league in the world, IPL comes with immense opportunities for advertisers and brands who are looking to target a huge number of people. IPL has broken the viewership record in 2023 and it is believed that in 2024, the viewership number is going to be increased outstandingly.\nAdvertising in IPL 2024 on Jio Cinema is one of the most remarkable opportunities for the advertisers as IPL on Hotstar was watched by million of viewers in 2022 making a drastic increase in the viewership from last season and which is now believed is going to be increased drastically in 2024. Jio Cinema App provides an easy option to advertise in the IPL 2024 matches.\nJio Cinema By Viacom18 is a Premium VOD online streaming app and website hosting over thousands of hours of content offering the best experience of TV Shows, Sports, and Movies in different languages according to your region. Jio Cinema provides full-length episodes and latest Bollywood and Hollywood movies and live sports streaming services of Cricket, Football, Badminton and etc. The Jio Cinema App majorly operates in 11 different languages including the national language Hindi. Jio Cinema App Advertising in India has developed such sturdy brand equity that this advertising media is trusted by brands, both established and upcoming.\nAlso Check – Advertising In IPL 2024 On Star Sports\nWhen it comes to reaching the audience of India, Advertising in IPL 2024 seems to be the best option that targets the audience in their homes & gives your brand a strong positioning equal to advertising on National Television Channels. Advertising Cost In IPL 2024 is as low as few lakhs, one can easily start branding in between the IPL as Jio Cinema provides it in a very budgeted manner. The Ads on Jio Cinema App are displayed in such a manner that it is showed to the user when he/she is engaged the most. IPL Advertising on Jio Cinema App in India Combines the power of TV-like engagement with digital-like segmentation. Segmentation can be done on various parameters like Identity-Based Targeting, Interest Profile Targeting, Advanced Targeting including the remarketing tools, a lookalike audience, custom audience, etc.\nAdvertising on Jio Cinema App in India is a dynamic medium of branding and is used by various brands to reach their TG (Target Group). Jio Cinema is India’s best online streaming app whether it is TV shows/Movies or Sports. Jio Cinema has covered it all under one app. The App provides live online streaming service of matches of different sports such as the Badminton, Cricket, Football and etc. In the world of Digital Advertising, In-App Advertising is doing wonders for brands, whether the aim is to reach the target audience, brand awareness, bringing traffic, or get app installs.\nThere are majorly two types of ad types available to advertise on the Jio Cinema app in:\n- Display Ads\n- Video Ads\nDisplay Ads: As the name indicates, these ads give your brand the space to drive installs on your app or visit your product or contact you. These ads are of two types, i.e. Ads with Images and Ads Without Images. These ads work on the basis of CPM (Cost Per Mile). Display Ads can be run on two price models, i.e. Impressions and Clicks.\nVideo Ads: Video Ads are the best when you want to create brand awareness through a short message video about your product/service. Video Ads are also of two types, i.e. Bumper Ads and Mid Rolls Ads. Video Ads work on two price models, i.e CPM(Cost Per Mile) and CPCV(Cost Per Completed View)\n- Bumper Ads: Bumper Ads are placed before the main program or event starts. These Bumper Video Ads are of 6 seconds or less.\n- Mid Rolls Ads: Mid Rolls Ads are placed in between the main program or event. These Mid Rolls Ads are of more than 20 seconds. This ad medium helps the brand to increase awareness and boost up its recall value by advertising an engaging story video of their product/services.\nClubbing Jio Cinema Advertising plan with other media plans like Television Advertising, Radio Advertising, Cinemas Advertising & Outdoor Advertising gives your brand a 360-degree coverage over your targeted audience.\nAdvertising in IPL 2024 on Jio Cinema App is now easy & affordable. Big Media Kart is a leading IPL Advertising Agency in India that offers an easy yet affordable platform to choose from various options. With an expert staff, Big Media Kart provides you with the best advertising plan to start branding in IPL on Jio Cinema App all over India.\nStill confused, Big Media Kart – The Best Jio Cinema App IPL Advertising Agency in India will help you to grab your targeted audience through a perfect customized & efficiently segmented ad plan.\nSome Random Jio Cinema App Facts:\n- Jio Cinema App has over 500 Million+ Viewership.\n- Jio Cinema App Has Content From Colors TV, MTV and Viacom 18 Owned TV Channels.\nDisclaimer: Prices are just indicative and may not be exact. Do not add any package/product directly into the cart or pay any amount before consulting one of our media experts. Any amount paid via www.bigmediakart.com without consultation from one of our media experts will be refunded after such case has been completely understood and acknowledged by us .\nContact Us For Best Rates & Proper Media Planning/Consultation.\nBig Media Kart does not take any responsibility for the prices indicated as they may vary on day to day basis.", "label": "No"}
{"text": "The candidates for this year’s BASC Council election have been announced.\nBallot papers will be sent out to all BASC members with the March edition of Shooting & Conservation magazine. Members will be able to cast their vote online from Monday 2nd March.\nThe 12 candidates for the five national seats are: Alisdair Troup, Nicholas Powell, Professor Ann M Mortimer, Simon Kibble, Sarah Turner, Peter Pursglove, Daryn Hufton-Rees, Neil Lawton Chalmers, Sally-Anne Cockerill, Allen Musselwhite, John Dryden and Martyn David Jones.\nBASC chairman Alan Jarrett said: “This is an opportunity for BASC members to help shape the future of the organisation and the future of shooting. The work of BASC’s Council is vitally important. BASC is the UK’s largest shooting organisation with a membership of more than 140,000. In 2015 we will be working with a new Government. All the indications are that we are heading into political uncertainty at the General Election and that means that there has rarely been a more important time to have your say on who should hold the BASC council reins and help steer the organisation through.”\nBASC chief executive Richard Ali said: “The over-riding objective of BASC’s Council is to oversee the management of the Association and to promote and protect the future of shooting. Council provides leadership, develops strategy, sets policy, ensures the necessary resources and monitors delivery. Being a Council member involves accepting and exercising responsibility at a high level. Members of Council are effectively the stewards of BASC’s funds, the trustees of its assets and play a key role in the ensuring the future of shooting sports in the UK.”\nVoting closes at 10.30am on 10th June.\nThe election results will be announced at the BASC AGM on 13th June 2015.\nBASC’s Council has 16 elected members and meets eight times a year.", "label": "No"}
{"text": "NATO allies this week committed to new large-scale\ndeployments to Eastern Europe to counter Russian threats, including\nUnited Kingdom fighter jets and US combat brigades.\nTwo Air Force intelligence, surveillance, and\nreconnaissance assets were used to bring down a small ISIS drone earlier\nthis month, the service confirmed.\nThe Air Force has tasked the Pentagon’s Defense\nInnovation Unit Experimental in Silicon Valley to work with industry to\nfigure out new ways to control small unmanned aerial systems.\nTweets by @AirForceMag", "label": "No"}
{"text": "When purchasing a firearm, expect a follow up email from us with a firearm acquisition form attached. Please fill out this form. Once we have confirmed your Firearm PAL information we can proceed to ship the firearm.\nStandard shipping on all items is $5 unless otherwise noted. Some exceptions may apply.\nShipping on all Firearms unless otherwise noted is $30.\nExcessively large or heavy items or multiple oversize items may cost more to ship and will raise your cost to the oversize shipping rates.\nAmmunition must be shipped dangerous goods and is therefore in store pick-up only. If you would like to speak to one of our customer service representatives about getting ammunition shipped dangerous goods freight, please call us at 709-535-6675", "label": "No"}
{"text": "At the annual Greenwich Village Halloween Parade, a professor's longtime dream will finally come true.\nProfessor Kenneth Jackson, who currently teaches History of the City of New York, will bring his students downtown to march in tonight's parade. The students will be dressed as various New York historical figures, and Spectrum hears from organizer Hannah Goldstein BC '13 that there will be a Walt Whitman, Carol Channing, Leonard Bernstein, and Gypsy Rose Lee just to name a few! The professor himself plans to be dressed as Barack Obama during his college days. His group is anticipated to be the first-ever New York City history-themed brigade to participate in the parade.\nWith his New York history class held biannually, Professor Jackson's class once before sought to complete the feat in October of 2012. Forty students were poised to march in the parade that year, along with several reporters who were looking to cover the story. However, Hurricane Sandy caused the parade to be canceled altogether. The class is being taught for the first time again since the occasion, and students are eager to give it another try.\nThe group will be led downtown from the 116th Street subway station on Broadway around 5 p.m., and the Village Halloween Parade will step off at 7 p.m. The group welcomes all who wish to join them. For further information, their Facebook event can be found here.", "label": "No"}
{"text": "Posts Tagged ‘Scottish Nationalists’\nTime for a Future Scotland of Head and Heart: A Challenge to Independence and the Union\nSunday Mail, March 22nd 2015\nScotland for many at the moment feels an exciting place. But for others there is a sense of dismay and confusion.\nThe latter is particularly evident in pro-union opinion. This week, ‘The Times’ commentator Magnus Linklater agreed with William McIlvanney’s recent revision of L.P. Hartley’s ‘the past is a foreign country’, referencing Scotland – ‘when you get to my age the present is a foreign country’.\nLinklater agreed. He noted falling oil prices, the economic balance sheet between Scotland and the rest of the UK, and pressures on public services. These should have led to a situation where Scotland ‘turned its back even more resolutely on the issue of independence’ and left the SNP ‘licking its wounds’. Yet the opposite was the case he conceded and he was baffled why. Read the rest of this entry »\nThe tartan tsunami and how It will change Scotland and the UK for good\nOpen Democracy, March 20th 2015\nThe UK general election campaign is upon us – struggling to make sense of the state of the country and how its institutions and politics are seen.\nUnderneath all the political rhetoric and exchange we are about to witness is tangible anxiety and unsureness about who ‘we’ are and the very existence, or not, of a ‘we’ in terms of connection, culture and collective memories – which can be found equally on both left and right.\nScotland has become one of the key reference points of this election: continually cited by the Westminster class and media, but seldom if ever understood. It wasn’t meant to be like this. The indyref was won 55:45 for the union. The issue was supposedly in David Cameron’s words ‘settled’, Alex Salmond seen off the political stage and the SNP juggernaut checked, if not stopped.\nScotland is at a seismic moment with huge implications and long-term repercussions not just for Scotland but the UK – as what increasingly looks like a tartan tsunami could sweep away scores of Labour once impregnable bastions north of the border. Read the rest of this entry »\nA Watershed Moment for Scottish Labour, Scotland and the UK\nSunday Mail, March 8th 2015\nScottish Labour’s predicament and condition is centre stage in British politics. It has become one of the major factors which will determine the fate of the next UK election and government.\nJim Murphy’s leadership, with its constant announcements and hyper-activity, whilst not having created the fundamental problems the party faces, seems to offer no real solution so far.\nUnderneath all this Scottish Labour does not understand the position it finds itself in and how to get out of it. Fundamentally the party does not comprehend the state of post-referendum Scotland it faces.\nIts problems have been a long time coming: the morphing of the party into the political establishment, its lack of imagination and purpose about what devolution was for, and finally, its lack of a progressive case for the union in the referendum, combined with their alliance with the Tories in ‘Better Together’. Read the rest of this entry »\nNicola Sturgeon, the SNP and the Age of Anti-Austerity Politics\nSunday Mail, February 15th 2015\nIt has been a week filled with economic news and controversies.\nThere was the imploding crisis of HSBC’s secret Swiss bank accounts and tax avoidance; the on-going Greek-German Governments European stand-off which threatens the future of the entire euro zone; while Mark Carney, Governor of the Bank of England, is getting people ready for a year of flat or even falling prices.\nAt the same time after years of public spending constraints and cuts, across large parts of Europe there is a widespread movement and force for anti-austerity politics. This can be seen in the rise of Syriza in Greece, the newly created popular Podemos in Spain, and – this week – in Nicola Sturgeon laying out the SNP’s position in a major London speech.\nSturgeon’s speech attracted lots of London media interest. And whether people agreed or not they took her and her agenda seriously. It was a considered and timely intervention, and seen as that by even her opponents. Read the rest of this entry »\nThe Myth of ‘Glasgow Man’\nSunday Mail, February 1st 2015\n‘Glasgow man’ is expected to be a critical factor in the forthcoming general election contest in Scotland.\nHe, or it, is central to Jim Murphy’s attempt to save Scottish Labour and win back 200,000 Labour supporters who voted Yes in the referendum. It is also pivotal to the SNP’s attempt to breakthrough in traditional Labour seats.\nGlasgow man is shorthand for a certain political demographic – the equivalent of ‘Basildon man’ who supposedly won it for Thatcher, and of ‘Mondeo man’ who contributed to Blair’s three election victories.\nGlasgow man is meant to represent men in the city, and in North and South Lanarkshire, aged between 25-40 years, who voted Labour in the 2010 Westminster election and didn’t in the 2011 Scottish Parliament contest, and who voted Yes in the referendum.\nGlasgow man implies a certain outlook: masculinist, certain and sure of their views, and reflecting the city, its politics and culture. Underneath there is a definite whiff of caricatures of working class men – of football, drink and tobacco, and more subtlely, of a sepia tinged radicalism and potent nostalgia. Read the rest of this entry »", "label": "No"}
{"text": "Chapter 440: Underground Research Base\nTranslator: Tim Editor: GlobeGlotter\nNo, I must wait for him to come back, thinking like this, Lu Yingying sat down.\nWhen Ye Mo got to the Yuan family mansion, there were five people in Yuan Zhirongs room.\nThere were three men on the left side, one of which was in his 50s and had a scar on his forehead. His nose was flat, yet he had a certain temperament to him. Ye Mo believed this to be Yuan Zhirong.\nThere was a person beside Yuan Zhirong who was already in his 40s but still looked very ferocious. There were two men on the right, one was the righteous looking man that had been at the feast. Then there was a youth next to this man who Ye Mo thought was probably Yuan Qibing.\nRemembering how this person had sent people to attack Ning Qingxue on the plane, killing intent appeared in Ye Mos eyes. If it wasnt for that Black Sun Empire, Ning Qingxue mightve really been abducted.\n\"Dad, your plan this time was really seamless. Even if that Yu from Flowing Snake knows we did it, she wont be able to do anything to us. Todays news was too satisfying! Luo Yue is over. Pity, if only that Ning Qingxue hadnt died, things would be perfect,\" Yuan Qibing said.\nThe middle aged man suddenly said, \"Young CEO, Ning Qingxue probably didnt die. I received news that this morning, an extremely pretty woman appeared in Flowing Snake. Based on the description, this person might really be Ning Qingxue.\"\n\"What?!\" Yuan Qibing stood up suddenly with a face full of excitement. He only had the image of Ning Qingxue in his mind, everything else didnt matter.\nA moment later, Yuan Qibing asked desperately, \"Uncle Ping, do you have her picture? Show me quick!\"\nThe man replied, \"No picture. Someone just happened to see her from a great distance and didnt have time to take a picture before the woman went inside. She never came back out. But apparently that womans husband also appeared in Flowing Snake, and he seems to be a higherup of Luo Yue.\"\nYuan Qibing was a bit dazed before clenching his teeth, \"No wonder Fei Yu was able to be chosen. I have to let that man watch on as I torture his woman!\"\nYuan Qibing quickly stopped though, as he saw his father sitting in front of him and felt that hed let loose too much.\nYuan Zhirong scanned Yuan Qibing and said, \"Put this thing aside. Women are just an extra compared to your career. If you cant even control this, how can I feel assured handing over Yuan Bei Corporation to you? If that woman was indeed Ning Qingxue, we must not touch her. The entire plane went missing, yet she is the only one thats fine. There must be a lot of people looking for her. Not to memtion, Luo Yue is far from over yet.\"\n\"Yes father, I know,\" Yuan Qibing returned to being calm and acknowledged guiltily.\nYuan Zhirong ignored Yuan Qibings reaction and said to the middle-aged man, \"Weiping, I know you just came back, but please report Flowing Snakes reaction nonetheless. By the way, when you did it, did you do it cleanly?\"\n\"Yes, President,\" The man answered and spoke immediately, \"This time, I targeted ten customers who bought the beauty pill and the health pill, with six of them having bought the beauty pill. After they ate one pill, I inserted some Blood Melting Serum into the other pills. No one will find out about it.\"\nYuan Zhirong nodded, \"Although its a little less than what we wanted, our goal has been reached.\"\nHowever, the middle-aged man said, \"Yes, although I targeted ten, six of them died after eating it. Only four lived, but their faces have been partially destroyed.\"\n\"Go to the compound and watch over the creation of the Blood Melting Serum. We need to make it more accurate. Also, the WQ033 virus must be urgently produced. We can release it when Luo Yue collapses.\"\nThe righteous-looking man intervened, \"Big Brother, Li Chunsheng seems to have a great background, and hes no simple man himself. Those last couple of times, the Senate wasnt able to do anything to him. I fear that once he consolidates his footing, no one will be a match for him. Now that hes responsible for the Health Department, I think we can start with the virus and give him a heavy blow. Even if we cant do anything to him, as long as we kick him out of He Feng, we win.\"\nYe Mo nodded. So this guy is Yuan Zhirongs brother? No wonder he could come to this meeting.\nYuan Zhirong hummed for a moment and said, \"That can surely be done. Once this virus spreads, it will cause horror. I believe no one can withstand the responsibilities of it. Since Li Chunsheng is managing this sector, start from He Feng. Though I believe we can choose Xi Tong Town as the starting point. When Li Chunsheng isnt able to keep his head above water anymore, you can attack him from the Senate, and we will find a suitable time to provide the cure and help you build up power.\"\nYe Mos eyes went cold. He didnt expect this Yuan Zhirong to be this heartless and mad, actually using a virus to attack his political enemies. Ye Mo wanted to kill them.\nBut even if he did, it would be of no benefit to Luo Yue, and the people outside would suspect them. Since he was going to attack, he would be completely destroying the Yuan family.\n\"Since were going to attack, we need to kill them in one blow. Weiping, watch Luo Yue closely. I believe that tomorrow morning, they will have someone give a talk. Before we it's safe and clear, dont make any moves. Recently, Luo Yue seems to have been much more strict. You need to remind our men to be careful,\" Yuan Zhirong said.\n\"I know, President,\" Weiping nodded seriously.\n\"Big Brother, when I go back, I will have the city government make a notice prohibiting the purchase of any of Luo Yues products. Then, I will ask Mayor Niu to hold a press conference.\"\n\"Okay, this will be the end of todays meeting. Well discuss our next move after seeing how Luo Yue reacts. Chang Hui, youre He Fengs Vice-Mayor, no one knows that youre from the Yuan family so far, so dont come here unless there are special circumstances,\" Yuan Zhirong nodded and reminded.\nSeeing them leave, Ye Mo sneered and packed away his camera. Other than that Weiping who was near the yellow level, all of them were ordinary people.\nYe Mo had decided to go to their factory to take a look first but before he did, he took out a needle and shot it into Yuan Qibings forehead.\nYuan Qibing stumbled and was held up by Weiping who asked, \"What happened to you?\"\nYuan Qibing shook his head, \"Nothing, Im just feeling a little dizzy. Its fine now.\"\nYuan Zhirong reproached, \"Youre this young, and youre feeling dizzy. Binger, I hold you in high regards, but I want you to start putting your focus on the company and not on women.\"\nYe Mo didnt want to listen anymore. He searched with his spirit sense and soon found a production factory outside the manor.\nThe entrance was in a well. Ye Mo used his camera to take pics as he jumped down. Although there were many alarms, they might as well have been just for show in front of Ye Mo.\nThe underground base was very big. Ye Mo suspected whether the Yuan family had even made it themselves. It was very spacious, with tens of men in blue uniforms checking bottles of serums. Looking at their white pale skin, it was obvious that they hadnt seen any sunlight for a long time.\nYe Mo immediately took out his camera to take pictures. It took only a few minutes before Yuan Zhirong came down with that middle-aged man.\nAs soon as he came, a researcher started to explain the progress to him.\nHe had to admit that these facilities were very secretive. It would be almost impossible for others to take pictures of this. Pity that Yuan Zhirong had encountered a cultivator.\nStrongest Abandoned Son Chapter 440\nTop weekly On WuxiaWorld\n- 1 My Youth Began With Him\n- 2 The 99th Divorce\n- 3 Elite Doting Marriage: Crafty Husband Aloof Cute Wife\n- 4 Perfect Secret Love The Bad New Wife Is A Little Sweet\n- 5 Handsome Ceo's Darling Wife\n- 6 Back Then I Adored You\n- 7 Trial Marriage Husband: Need To Work Hard\n- 8 Full Marks Hidden Marriage: Pick Up A Son Get A Free Husband\n- 9 The Most Loving Marriage In History: Master Mu’s Pampered Wife\n- 10 Super God Gene", "label": "No"}
{"text": "Imagine touring Europe for 16 days with a bus full of high school band geeks. It was awesome being one of the high schoolers. But I imagine it was less awesome being one of the chaperones. Especially when we did things like play with the crystal glasses in a semi-formal Swiss restaurant. Hey! It's real! At least we were all musicians.\nSome creative person decided to make life better for chaperones of musically-inclined, crystal-playing high schoolers (and those of us who would still play with their wine glasses on occasion, even into adulthood). Instead of guessing at pitches, these glasses conveniently mark how much water needs to be filled in order to get specific notes. The set of 12 glasses gives you a full octave.\nMy question: but in what key?\nFound at Luna and Curious.", "label": "No"}
{"text": "By David Nield\nHumans are about to make history by sending a little piece of a Martian rock back to the surface of Mars for the first time ever.\nThe meteorite fragment Sayh al Uhaymir 008 (or SaU 008) will hitch a ride on the 2020 NASA Perseverance rover mission on Thursday – some 600,000 years after it left the Red Planet, and around 1,000 years after arriving on Earth.\nPerseverance is going to use SaU 008 to calibrate its sensitive scanners and instruments once it lands, treating it as a reference point for the other rocks and materials that it’s going to come across in its journey across the Martian surface.\nThere’s still plenty that we don’t know about the geological make-up of Mars, and a rock fragment that we know originates from the planet – and that has already been extensively analysed – is going to be a helpful comparison point.\nContinue reading by clicking the name of the source below.", "label": "No"}
{"text": "Biodiversity Heritage Library\nBy \"Harris, Elisha, 1824-1884\"\nTobacco : the effects of its use as a luxury on the physical and the moral nature of man ; a prize essay /\nBy: Harris, Elisha,\nPublication info: New York :Wm. Harned,1853.\nHolding Institution: Yale University Library", "label": "No"}
{"text": "South Armagh: just typing the words evokes emotion. I suspect everyone has a story to relate about The Troubles, especially if you lived in the UK in the 70’s and 80’s and most especially if you lived in Northern Ireland. While I was in Ireland last week I heard great stories about the people of South Armagh that were surprising and inspiring. And I want to share them with you.\nOver 800 years, and probably before that, one thing seems to be a constant, the people of South Armagh have always found creative ways to address their needs. As the joke goes “Only two things in life are certain, death and taxes, and in South Armagh they’ve got it down to one.”\nA major component of The Troubles was economic. Very high rates of unemployment and poor (at best) and discriminatory (at worst) social services meant that too many people were without any source of support for themselves or their families. In South Armagh the solution, the solution that Slick Willie chose, was to rob banks “because that’s where the money is.” Crime families evolved into powerful undercover corporations providing employment (of a kind) and money in exchange for dangerous and illegal activities in support of one cause or another.\nWhen the banks closed their doors these families turned to other enterprises like smuggling, arms dealing and a host of other “lines of business” all the while being under the most intense scrutiny of not only the Ulster Constabulary and the Garda but also might of the British Army. And, for the most part, they escaped detection (and taxes).\nIt seems that the people of South Armagh have a talent for solving very tough problems with very elegant solutions and they are not bounded (clearly!) by rules, laws or conventional thinking.\nAnd its geographic location could not be more perfect. It forms a powerful business triangle with Newry and Dundalk and can exploit the border proximity along with its neighbors (as it has for centuries).\nThe real DNA of the people of South Armagh is extreme problem solving in truly adverse conditions. Now that peace has descended it is time to turn this creativity towards new kinds of businesses that profit the people and the place. This generation of young people in South Armagh can change the images and memories that the name evokes to something all can be proud of.\nMany thanks; on the island of Ireland we suffer the legacy of occupation. One of the things we don’t do is talk openly or process things aloud. “Whatever you say say nothing” is a sentiment long felt in Northern Ireland and all along the border. Tommy Makem had a well known song (http://goo.gl/kX9wc) and Seamus Heaney a poem (http://goo.gl/H62rx) by the same title. Silence and obfuscation were once necessary, they are no longer.\nThere is a new reality decades into the peace process – it is a concerted effort by business people in the Republic and in Northern Ireland to accept that we are a small island best served economically by creating a larger, all island, marketplace.\nTaken a step further we need to attract foreign investment to both countries – to the Island. And the Irish Diaspora can help.\nOne in 7 people in the Republic owe their jobs to foreign investment. Northern Ireland has invested in a project which brings the fastest data transmission between the US and Europe to our shores – with connections in both Northern Ireland and the Republic. Google is here, Facebook is here, American and European pharmaceutical and bio tech firms are here. Our construction companies are exporting expertise and building in the Middle East and South America.\nWe have the youngest and best educated English speaking workforce in Europe.\nWe need to speak aloud, we need to shout a message of economic opportunity to the world.\nWe need to find a common language in which to share and celebrate our successes. The din of that celebrating would be the best means to silence the naysayers who would threaten what was once a peace process and is now a prosperity process!", "label": "No"}
{"text": "Kahoot is a game that can be played on any device and is designed to help people learn. It’s an easy way for students to take their learning outside the classroom, or for teachers to incorporate into their lessons. Kahoot also has a social aspect where players can compete with each other in different ways.\nKahoot is a game that allows students to compete in groups. The game can be streamed online and played by multiple people at the same time.\nThis Video Should Help:\nKahoot! is a game-based learning platform, used as educational technology in schools and other educational institutions. Its learning games, “Kahoots”, are user-generated multiple-choice quizzes that can be accessed via a web browser or the Kahoot app. Kahoot is free to use for educators, with a paid premium package available for businesses.\nKahoot can be used in different ways depending on the goals and needs of the educator. It can be used as a video conferencing app, a website, an ideas board, or even a teaching tool. Kahoot is also available in a paid premium package for businesses.\nWhat is Kahoot?\nKahoot is a game-based learning platform that brings the magic of learning for all ages. Kahoot is used in a variety of settings, including education, business, and homes. You can Kahoot on any device, including phones, tablets, and computers.\nKahoot is a fun and interactive way to learn. It is perfect for educators, employees, and students of all ages. Kahoot can be used in class, during professional development, or at home. You can even use Kahoot to teach your kids!\nWhat is Kahoot?\nKahoot is a game-based learning platform that brings the magic of learning for all ages. Kahoot is used in a variety of settings, including education, business, and homes. You can Kahoot on any device, including phones, tablets\nHow to stream Kahoot?\nKahoot! is a game-based learning platform that makes it easy to create, share and play learning games or trivia quizzes in minutes. Kahoot! can be used in the classroom to enliven lectures and review sessions, or for team-building and networking events. Itufffds also a great way to add some fun to remote conferences and meetings!\nYou can stream Kahoot! directly from our website or via the mobile app. To do this, youufffdll need to create an account and log in. Once youufffdre logged in, you can either create a new game or search for an existing one.\nIf youufffdre using Kahoot! for the first time, we recommend checking out our tutorial videos. These will show you how to get started and give you some ideas for ways to use Kahoot! in your classroom or workplace.\nKahoot streaming tips\nKahoot is a game-based learning platform that makes it easy for educators to create engaging and interactive quiz-style games that can be played in the classroom or remotely. Kahoot can also be streamed to larger audiences via video conferencing apps or the Kahoot website, making it a great way to engage employees or teach large classes. Here are some tips on how to stream Kahoot:\nIf you’re using Kahoot in the classroom, you can stream your games live to any video conferencing app that supports screen sharing. This includes popular apps like Zoom, Google Hangouts, and Microsoft Teams. To do this, simply start your game as usual and then share your screen with the app. Your audience will be able to see the game on their devices and play along.\nIf you’re streaming Kahoot to a larger audience via the Kahoot website, you can use our built-in live streaming feature. Simply start your game as usual and click the “Live Stream” button in the bottom left corner of the screen. This will open a new window where you can enter your live stream URL and start broadcasting. Your audience will be able to watch the game on the website and play along.\nIf you have any questions about how to stream Kahoot, feel free to reach out to us at [email protected]\nHow to make your Kahoot stream more engaging\nIf youufffdre looking for ways to make your Kahoot stream more engaging, youufffdve come to the right place. Whether youufffdre an educator teaching a class or an employee presenting to coworkers, we have some ideas for you.\nFirst, letufffds go over how to stream Kahoot! on our website or in our app. Then weufffdll give you some tips on making your Kahoot stream more engaging.\nTo stream Kahoot! on our website:\n1. Go to kahoot.it in your web browser and sign in.\n2. hover over your profile picture in the top-right corner and select ufffdSettingsufffd from the drop-down menu.\n3. On the ufffdSettingsufffd page, scroll down to the ufffdVideo streamingufffd section and toggle the switch next to ufffdEnable video streaming for my Kahootsufffd to turn it on..\n4. Now, when you go to play a Kahoot!, you should see a ufffdStart streamingufffd button just below the ufffdPlayufffd button..\n5. Click that button and then choose whether you want to use your webcam or screen sharing..\n6. Once you start streaming, people who are playing along with you will be able to watch your video in real-time..\n7. Thatufffds it! You are now ready to stream Kahoot!. If you want more tips on how to make your Kahoot stream more engaging, read on.\nSome ideas for making your Kahoot stream more engaging:\n1. Use props or physical gestures: If you are using your webcam, props or physical gestures can help make your points more clearly.. For example, if you are teaching a lesson on parts of the body, hold up a flashlight under your chin so people can see what happens when we say certain words..Or if you are demonstrating how to do something physically, like bake a cake, use hand gestures along with your explanation..\n2. Be animated and enthusiastic: Show that you are engaged in what you are saying by speaking with animation and enthusiasmufffdYour energy will be contagious and will help keep people engagedufffd\n3. Make eye contact with the camera: Another way to show that you are engaged is by making eye contact with the cameraufffdThis will help people feel like you are talking directly to themufffd. It may feel strange at first, but try looking at one person in particular when you speakufffd It will help make your presentation feel more personalufffd. Making eye contact also shows that we are interested and trustworthyufffd People are more likely to believe what we say if we look them in the eye when we say itufffd.\nHow to use Kahoot for educational purposes\nKahoot is a video conference app that allows up to 10 people to join a video call. It can be used for educational purposes, such as teaching a class or holding a meeting with employees. Kahoot also has a website where you can find ideas for games and activities to use with the app.\nThe benefits of streaming Kahoot\nKahoot is a powerful tool that can be used by educators, employees, and evenevent planners to share ideas and engage with their audience. The Kahoot app allows users to create and share custom video kahoots that can be played on a website or conference app. Kahoot also offers a variety of features that make it easy for educators to use in their teaching.\nKahoot streaming case studies\nHow Do I Stream Kahoot? is a question that often comes up from educators who want to use Kahoot in their teaching. There are a few different ways to stream Kahoot, depending on your needs.\nIf you want to use Kahoot in a live setting, such as in a classroom or conference, you can use the Kahoot app. The app allows you to share your screen with others so they can follow along with the game.\nIf you want to use Kahoot as part of a recorded lesson or presentation, you can use the Kahoot website. The website allows you to record your voice and video as you play the game, so viewers can watch and learn at their own pace.\neither way, streaming Kahoot is a great way to engage and teach employees or students. If you have any questions about how to stream Kahoot, please don’t hesitate to contact us.\nThe future of Kahoot streaming\nKahoot, the popular platform for educational games and quizzes, is now available to stream live video. The new Kahoot Live app makes it easy for educators to host virtual conferences and workshops, employees to share ideas remotely, and students to connect with each other outside of the classroom.\nThe app is free to download on the Kahoot website, and itufffds available now for iOS and Android devices. UValde ISD is one of the first school districts in the country to pilot the app, and weufffdre excited to see how it can help our teachers continue teaching and our students continue learning.\nFAQs about Kahoot streaming\nKahoot is a game-based learning platform that can be used in the classroom or for employee training. You can stream Kahoot games live to a conference or through the app to teaching ideas.", "label": "No"}
{"text": "Friday, March 4, 2016\n6-10 p.m. (last entry 9 p.m.)\nCelebrate the British Isles and all things green at Off the Clock: Kilts and Clovers. The event takes place in the lush Orangery, tropical Marnie’s Pavilion and Boettcher Memorial Center. Savor special dinners at Offshoots Café and drinks at the cash bar.\n- Enjoy the sounds of traditional Irish and Scottish music by Colorado Spring’s Rare Ould Times.\n- Star Edwards performs on the Celtic harp.\n- Listen to tales of myth and magic recounted by the Story Seeker and Celtic folksongs from Gobs O’Phun that tell stories ranging from silly to sad and everything in between.\n- Irish step dancing performance by Celtic Steps.\n- Solo bagpipe performances throughout the evening.\n- Compete for top bragging rights in a tricky scavenger hunt and participate in the kilt and Celtic costume contest.\n- Offshoots Café offers a special menu\nAlso join us for:\nFriday, April 1\nSPECIAL THANKS TO", "label": "No"}
{"text": "Need candidate for the below mentioned profile.\n1 Sr Executive - Return Management\nGood Knowledge of Ecom industry\nShould be well versed with return policies of Ecom portals - Amazon, Flipkart etc\nHe / She would be responsible to properly receive the returns from courier partners and endorse the POD as per portal policies\nHe / She would be responsible to properly account for all returns.\nHe / She would be responsible to handover all returns to various stores in office\nHe / She has to analyze all returns, portal wise and category wise, and take suitable actions to reduce / control the returns as per agreed norms\nKnowledge of order processing and OMS inventory platform would be preferred\nMust have worked in similar function for min one year.\nGraduate with three years experience, however MBA from a recognized institute / university would be preferred.\nSalary offered would be Rs15-25 k per month.\nJob Location : Mayapuri West Delhi.\nCandidates should have the asked & relevant experience only please contact at 8851601541/ 9899966291.\nWhats app resume @ 8851601541 / 9899966291.\nPosted on: 02 Sep, 2020", "label": "No"}
{"text": "Simply confirm your registered email address below and click \"Reset Password.\" We will immediately email you a link back to the site where you can enter a new password for this account.\nJoin The Wiseman and the Town of Babylon for a Free Summer Concert at Overlook Beach featuring \"Big Shot\" - The Ultimate Billy Joel Tribute Experience!\nCopyright © 2015. All rights reserved.", "label": "No"}
{"text": "“Working with Alarm Engineering, specifically David Mueller in the DE division has been a pleasure. Their ability to offer our new home buyers much desired options as well as accountability, responsiveness, professionalism and knowledge of the products they offer is superb. David has been flexible and helpful and dedicated to making sure that the customers he meets are aware of all their options and teaching them about new technology that is available to them without being overwhelming. Thumbs up to them and a big thank you for all you do.\n-Shelby L. @ Beazer Homes in Millville, DE on Google", "label": "No"}
{"text": "The latest in a long line of videos I never knew I wanted to see shows us how restaurant napkins are made. The video is from the YouTube channel, Mind of a Chef.\nOne of the perks about shelling out money at a nice restaurant is getting to use their fancy napkins, except for the fact you almost feel bad about using them.\nRecently, Mind of a Chef visited and filmed a video at Rivolta Carmignani, located in Macherio outside of Milan, where such napkins are made.\nLucky for us, they detailed the entire restaurant napkin-making process in the video below.", "label": "No"}
{"text": "ITRE adopts 35% renewable energy target for 2030 – can bring EU back on track to global leadership say RES associations\nOne year ago, the European Commission presented the Clean Energy for All Europeans legislative package, but its headline target of 27 percent renewable energy by 2030 fell short of its ambitions. With today’s vote, adopting a target of at least 35 percent renewables, the European Parliament Committee for Industry, Research and Energy (ITRE) puts the EU within reach of meeting its objective of being a world leader in renewables, a move widely welcomed by Europe's renewable energy associations.\nIn a joint statement, ten European renewable energy industry trade associations; European Association of Renewable Energy Research Centres (EUREC), European Biogas Association (EBA), European Biomass Association (AEBIOM), European Geothermal Energy Council (EGEC), European Heat Pump Association (EHPA), European Renewable Energies Federation (EREF), European Solar Thermal Electricity Association (ESTELA), European Solar Thermal Industry Federation (Solar Heat Europe – ESTIF), Ocean Energy Europe and Solar Power Europe have welcomed the adoption of the new target.\nWe welcome the approval of an EU binding renewable target of at least 35 percent by 2030. Through this vote, MEPs send a clear signal to the industry, that investments in renewables must follow at least the same pace than in the last decade. We now call on the Council to endorse these ambitions and make sure they will be delivered through a robust Governance framework, said James Watson, CEO of SolarPower Europe.\nThe European energy sector must fully decarbonise to comply with the objective of the Paris Agreement and keep average global temperature increase below 1.5°C.\nIn view of the Paris agreement, we need a strong national obligation besides ambitious targets of at least 35 percent, said Dr Dörte Fouquet, Director, EREF.\nA 35 percent renewable energy target in 2030 is, however as some of the signatories point out, the “bare minimum” required to maintain the fast-paced growth of the renewable sector in face of increasing international competition.\nA 35 percent renewable energy target by 2030 would keep Europe in the game in terms of global renewable energy technology leadership, and generate significant jobs, growth and export opportunities. The Rapporteur has done an excellent work in reaching such a strong cross-party agreement, said Rémi Gruet, CEO of Ocean Energy Europe.\nA strong and vibrant domestic market will ensure Europe reaps the economic benefits of a clean and efficient energy system fit for the twenty-first century.\nThe 35 percent renewable energy target voted today calls for more ambition also at the decentralized level. Renewables in buildings must get a real boost in the next decade if this target is to be reached, said Pedro Dias, Secretary-General, Solar Heat Europe.\nFor the EU to be a world leader and remain a driving force on climate action, European and national policies must allow for a thorough penetration of renewable energy in all segments of the energy sector: electricity, heating & cooling and transport.\nHowever, provisions adopted on heating and cooling are not quite ambitious enough to prevent the EU from locking in fossil fuels in this sector, nuanced Jean-Marc Jossart, Secretary-General, AEBIOM.\nThe signatories conclude that a robust and reliable governance framework, including sound planning and steady renewable deployment trajectories, is now needed to back the “at least 35 percent” target and provide renewables investors with the long-term perspective they need to plan industrial activities.", "label": "No"}
{"text": "I made an awesome creature. Do you want to see it?\nYes! I love seeing all of the great creature designs and simulation results that you come up with.\nYou can post them here\nor send me an E-mail or a Tweet\nI won‘t be able to reply to all of them, but please know that I do see and appreciate everything you send me!", "label": "No"}
{"text": "\"J.W. Bizzaro\" wrote: > Brad Chapman wrote: > > > > It seemed to me the plan is pretty controversial since it proposes > > that all remote communication occur through the definition layer (the > > middle scripting layer) and not at the level of node processing. It > > was based on my attempts (probably failed) to learn about methods > > for implementing distributed systems based on Jarl's suggestion that > > all remote note authentication should occur in the definition layer. > > The proposal is basically derived from some systems I read about where > > the corba/distributed layer was implemented separately from the layers > > that do the actual work (the processing layer in our case). I tried to > > adapt it to the vsh setup. > > I thought communication (between cores) would occur in the brokering layer. > This is what GMS was going to handle, right? If communication occurs through > the Python-based definitions layer, what is the broker layer used for? It > must be used for more than communicating with Overflow (processing layer). Like the name already suggest: brokering layer, so the comm. between instances will be handled by the BL (gms). I dont know what is Brad want to build, but it seem to have something to do with DL specific stuff.", "label": "No"}
{"text": "What are ways of distributing, or partitioning, or fragmenting presence when being together?\nInsignificant Others (learning to look sideways) displays processes of the performers co-operating in modes of conducting, structuring and shifting a shared topography of physical presence and absence in fragmented cycles of movements.\nThe performers are as spectres and carriers of ambiguous images, still and fluctuating. A series of discontinuous but interconnected still postures that make images and situations between the performers but never quite build a shared narrative. Rather than a dramaturgy of determination, the artists are simultaneously working alone together as if in a field of energy that needs careful management, redistribution and direction, here they are making a dance out of the reabsorption of this energy field into the bodies of the empty space, themselves and the perception of audience. Harboured in that which is deemed unaffirmative pure potential is what is performed.\nConcept/Choreography Ian Kaler Performance Alex Baczynski-Jenkins, Ian Kaler and Antonija Livingstone / Dolores Hulan (Krakow, Leuven) Lightdesign Bruno Pocheron Space Stephanie Rauch Music/Sound Brendan Dougherty Dramaturgy Heike Albrecht Fotos >> Eva Würdinger Project Management das Schaufenster Production >> Ian Kaler Coproducer >> Tanzquartier Wien, >> Tanzfabrik Berlin, >> TANZTAGE BERLIN / >> Sophiensaele With the support of >> Wien Kultur, >> Österreichisches Kulturforum Berlin, >> advancing performing arts project and >> Turbo Residence Impulstanz\nRencontres chorégraphiques internationales de Seine-Saint-Denis\n12th (17:00h) and 13th (18:00h) of May 2012 / La Chaufferie (Saint-Denis/F)\nProduction >> das Schaufenster\n>> programme of the festival\nTANZTAGE BERLIN programme 2012\n>> Playbill Insignificant Others (learning to look sideways) / Tanzquartier Wien (2nd and 3rd of December 2011)\n>> Playbill >> Insignificant Others (Excerpt) / Tanzquartier Wien (19th of November 2011)", "label": "No"}
{"text": "Friday, April 10, 2015\nPublication on Kerr black hole momentum by Assistant Professor of Physics Robert Owen\nNearly extremal apparent horizons in simulations of merging black holes.\nClassical and Quantum Gravity 32(6):065007 [A journal from Institute of Physics @ IoPScience]\nThe spin angular momentum S of an isolated Kerr black hole is bounded by the surface area A of its apparent horizon: 8 pi S A. We show that the overspun surfaces are indeed superextremal: our lower bound on their Booth-Fairhurst extremality exceeds unity. However, we confirm that these superextremal surfaces are always surrounded by marginally outer trapped surfaces (i.e., by apparent horizons) with 8 pi S < A. The extremality lower bound on the enclosing apparent horizon is always less than unity but can exceed the value for an extremal Kerr black hole.\nAccess on the OhioLINK Electronic Journal Center.", "label": "No"}
{"text": "by Michal Furmanek [MFphotoart]\nClicking on an item will take you to Etsy.com. As an affiliate, we will be compensated if you make a purchase after clicking. This does not affect the price you pay.\nCurrent Status (2023-12-04) : Available [More info].\nGreat Horned Owl photo print, nature photography wall art. Picture of mama owl sitting by her nest in the old tree. Available on paper (unframed and framed), canvas, and framed canvas. Select from a variety of sizes - from 5x7 to 16x24 inches. Feel free to send me a message if you need a custom size or if you have any other questions; I respond quickly. For more bird pictures, please visit the BIRDS section of my shop: https://www.etsy.... More >", "label": "No"}
{"text": "We called Tim our soul brother. I often told him that he was an Evangelist of Art.\nFind the RAIL in print\nA message from Phong Bui\nPublisher and Artistic Director\nGet notified about upcoming live conversations with artists and when the next issue of the Rail drops.", "label": "No"}
{"text": "PRactices Of Governance, Resilience, Environmental & Social Sustainability\nWelcome to Maureen Reed’s PROGRESS lab in the School of Environment and Sustainability at the University of Saskatchewan. Here, we are all confronting the overall question: What models of governance and action can help communities become resilient and make progress towards environmental and social sustainability?\nMost of the research in the PROGRESS lab is conducted in rural places. Our research communities are dynamic; they face interconnected environmental, social, economic political and cultural changes. Some of these changes happen rapidly, such as during extreme events like flooding and forest fires. Other changes happen over generations, such as expectations about gender or indigenous-settler relations and how these expectations affect decisions made about environment and sustainability. We study both fast and slow-moving changes and consider how to support transformations for equitable, resilient, vital and sustainable communities.\nWe work with our research communities to identify research questions and answers to inform practices, policies and processes. Our philosophy is that local communities and organizations have the capacity to address and even shape environmental and societal change; our inquiries seek to reveal and enhance these capacities. Through detailed case studies, careful comparative analyses, and broad-based national inquiries, we hope to provide lessons that residents, communities, organizations and governments can use.\nOur work spans a range of models and practices. In Canada, we work in biosphere reserves, model forests, community forests, and Indigenous territories. Beyond Canada, we conduct research in similar contexts. We share our results with local communities, local-national governments, private sector interests, United Nations agencies, and scholars around the world.\nPlease review these pages to explore the kinds of research that have kept us awake at night and that get us out of bed each morning!", "label": "No"}
{"text": "The city of Erie is fighting a state appeals court ruling that restricts a major part of its rental-inspection program.\n\"This case is of importance to the city of Erie and its residents, particularly residents in rental properties, as well as the owners of the properties,\" Assistant City Solicitor Kenneth Zak wrote in a motion to Commonwealth Court.\nA three-judge panel of the nine-member court unanimously ruled against the city on March 12. The panel said the city ordinance for the 8-year-old rental-inspection program, with exceptions, does not apply to buildings older than July 8, 2004, or the date the city adopted the Uniform Construction Code.\nThe city is asking the Commonwealth Court to rehear the case en banc, or with a panel of seven judges. The city could appeal to the state Supreme Court if the Commonwealth Court ruling stands.\nThe Erie landlord who won before the Commonwealth Court, Lance Howell, is opposing the city's request, Howell's lawyer, Michael Musone, wrote in a motion filed Monday.\nThe case concerns what the city said was an unsafe amount of headroom in a stairwell. The city argued the rental-inspection ordinance allows the city to enforce safety rules for all rental properties, no matter how old. Erie County President Judge Ernest J. DiSantis ruled for the city in 2013.\nMusone successfully argued on appeal that the city failed to prove that Howell's stairwell is unsafe. And he argued the rental-inspection ordinance was too broad because the city could force landlords to make changes to safe buildings.\nThe Commonwealth Court panel said the city can still require a landlord to change a building older than July 8, 2004 -- but only if the building is unsafe or if the landlord has taken out a building permit to modify the building to rent it.\nED PALATTELLA can be reached at 870-1813 or by e-mail. Follow him on Twitter at twitter.com/ETNpalattella.", "label": "No"}
{"text": "Read reviews and take a turn at playing your child's favorite Neverwinter to keep yourself involved in what your child is experiencing. Test these games out and watch your kid play. You could even play along with them. Try to communicate by asking questions and show that you are interested in their gaming adventures. That's the best way to experience it.\nA Playstation 2 gaming system is a great, low cost console system. PS2 game prices generally run about 50% of the price of games for a modern console. It has been around for 10 years, so there are plenty of games out there available for it.\nIf you find a Neverwinter at a great price, look up the Metacritic score prior to making a final determination about whether to buy. It may be on sale because nobody likes it. To save yourself frustration, use the Metacritic score. The game's score will tell you whether it's worth buying or not.\nThink about going to an arcade that is a bit far from home. These days, the majority of gamers use their own consoles at home. If you go out of town to an arcade, you can enjoy your games along with some human interaction.\nIf you're looking at purchasing a new video game, you can reserve it before it actually comes out. You may get special bonuses when ordering early Buy Neverwinter PS4 Astral Diamonds. These can include game gear or features that may only be available pre-release.\nLocal going-out-of-business sales are a great source for cheap games. Some video rental businesses are hurting now. If you look, you might find a video store that is going to close soon and find some fantastic deals on games and accessories. Usually, you will find the discs are usable, but they may need a good cleaning.\nNeverwinter can teach you, entertain you and relax you. There really are some amazing benefits to gaming. With any luck, you now possess the knowledge necessary to game intelligently.", "label": "No"}
{"text": "Raw Sweat Vol. 2\n|Rosebud (1998) (Gay Feature)\nRelease Year: 1998 Cast: Joey Hart Johnny Dean Griff Thorson Kurt Young Tommy Cruise Gregg Arlen Jay Strong Wade Peters Brian Roberts Vincent Demarco Genres: Feature Muscles Safe Sex Video language: English Private Investigator Mickey Chandler (Kurt Young) is hired by District Attorney Lex Bender (Johnny Dean) to re-investigate the of high-priced hooker Steven Shostak (aka Buddy Rose). The...\n|Rosebud (Gay Feature)\nStudio: Studio 2000 Private investigator Mickey Chandler (Kurt Young) is hired by DistrictAttorney Lex Bender (Johnny Dean) to re-investigate the of high-priced hooker Steven Shostak (aka Buddy Rose). The D.A. knows that Jack Thorton did it, but he has no proof. And he knows that it would be double jeopardy to re-try him for the same crime. But it«s more than that, it»s personal....\n|Rosebud Male Video – Gang Bang Alley (1992) (Gay Feature)\nRelease Year: 1992 Cast: Randy Storm, Vic Hall, Tad Garrett, Cody James, Trey Tempest, John Robertson, Bill Wadkins, Ross Atkins, K.C. Obanian Genres: Condoms, Hunks, Back Alley Sex, Group Sex, Rimming, Oral Sex, Anal Sex Horny studs sucking and fucking each other back street style! Enjoy! Total size: 4.8 GB in 3 files. http://svalka.ws/...\n|Spunk Video Bottomed Out (Gay Feature)\nWhen we shot slutty Timm Zane in Palm Springs as part of the Timm was truly in hog heaven as for the entire long weekend he got fucked, and fucked, and fucked some more, until he practially couldn«t walk anymore. What was his secret? Well, the Captain Morgan for breakfast didn»t hurt, but it«s just that this man lives for a cock in his ass, preferably spewing manjuice deep, deep...\n|Daddy Says Billys Back (Gay Feature)\nStudio: U.S. Male Studios Billy Bandt is back! And what a sight! Featuring an eye popping double penetration, this dick drenched, dy sex fest is guaranteed to keep you mentertained for years and years to cum! Format: avi Duration: 1:31:28 Video: 512x384, DivX 5, 939kbps Audio: 88kbps File size: 698.0 MB http://svalka.ws/...\n|In-N-Out (Gay Feature)\nRelease Year: 2007 Studio: Red Eagle Films, Spunk Video Cast: Nick Savage, Eddie Reno, Rex Armswell, Sean Steele, Bud, Ty Hurt, Chris Coe, Brett Berlin, Bad Pig, Daxx Reed, Orion Cross, Spencer Hartt, Erik Erikson, Mitch Banning, Earl Howard, Eagerboy Genres: Extreme Penetration, Pigs, Butt Play, Fisting, Oral, Pissing, Leather, Masturbation Wolfgang Bang squirreled away scenes throughout...\nBattle Level 4 3D Porno\nSonthaya More Anal Asian Uncensored\nEastBoys Martin Gajda Casting Handjob Muscle Worship Part 2 Gay Extreme\nJinnis Adventure Games Porno\nAsia Boy Lost in Passion Gay Asian\nI'm Gonna Bang Big Boobs Milfs Big Tits\nReal Ecstasy Gay Asian\nThe Guts part2 Anime, Hentai\nSession 263 - juice The Shitty Water Coming Out Of My Arse! Gay BDSM\nZiggy Star Congratulations To Ziggy For Earning Her Hardcore Porn Badge (2017) Orgy", "label": "No"}
{"text": "England women drawn against France, Russia and Spain at Euro 2013\nEngland will face France, Russia and Spain in the group stage of the 2013 European Women's Championship.\nHope Powell's side, who were beaten by Germany in the final in the 2009 tournament, learned their opponents in today's draw in Gothenburg.\nEngland drew 2-2 with France in a friendly in Paris last month and qualified unbeaten for next summer's Euros.\nGoing to the Euros: Hope Powell will lead England next year\nThey will open their campaign against the Spanish on July 12, before meeting Russia three days later and then Les Bleus on July 18, with the matches taking place in Norrkoping and Linkoping.\nIn the other pools, hosts Sweden were drawn alongside Italy, Denmark and Finland in Group A, while five-time defending champions Germany take on Norway, Holland and Iceland in Group B.\nSweden will open the tournament against Scandinavian rivals Denmark on July 10.\nMost watched Sport videos\n- Man City 1-3 Chelsea: Pep Guardiola press conference\n- Souness plants Galatasaray flag and enrages Fenerbahce fans\n- Wenger happy that they didn't pay for the chance they missed\n- Mob storm police station and lynch suspected paedophile\n- Nico Rosberg wins his first Formula One world championship\n- See Mourinho's Manchester United record versus his predecessors\n- Slaven Bilic apologises to West Ham fans after humiliating defeat\n- Boxer Anthony Joshua trains in the gym with Jamie Reynolds\n- Gareth Southgate praises Sky Sports reporter Nick Collins\n- Robin van Persie and son Shaqueel keepy ups for Fenerbahce fans\n- 100 special police agents protect suspected paedophile from mob\n- Haye and Bellew throw punches at each other during press conference", "label": "No"}
{"text": "DG ISPR takes journalists to forward positions in Bhimber sector to confirm the falsehood of Indian claims of ‘surgical strikes’\nSays India again started unprovoked firing on Saturday\nAs tensions escalate between Pakistan and India over recent ceasefire violations by India on the Line of Control (LoC), the Pakistan army on Saturday claimed that the Indian forces had suffered considerable losses due to Pakistan’s “befitting response” to the Indian firing.\nPakistan Army took a group of journalists to forward locations at the LoC in Azad Jammu & Kashmir (AJK) to prove recent Indian claims of conducting surgical strikes inside Pakistani territory a “farce”.\nWhile briefing media at the forward location of Baghsar and Tatta Pani areas of Bhimber district, AJK, Director-General of the Inter-Services Public Relations (ISPR) Lt General Asim Saleem Bajwa told reporters that the Indian claims of conducting “surgical strikes” into Pakistani territory were mere lies.\nHe said that Indian soldiers had lost lives in crossfire after Pakistani forces retaliated to the Indian fire. He said the Indian army was not accepting the loss of lives at their end. “We are certain that they have suffered casualties. But why they are not admitting to this is a question which needs to be put to them,” he said, adding that India was concealing the losses it had suffered due to Pakistan’s response. “It is not clear why India is hiding its losses,” the DG ISPR said, but reminded India that “war is not in anybody’s interest”.\n“Pakistan Army is fully prepared to take any misadventure with more effective and strong manner. We have defended our homeland in the past, and we are committed to doing so in the future,” he added.\nGeneral Bajwa said that he himself had shared information about the two soldiers that embraced martyrdom, adding that the media freely covered their funerals and that those injured were sent to Jhelum CMH but they insisted on returning to service.\nThe DG ISPR said that Pakistani troops befittingly responded to unprovoked Indian firing, which started at 4.00am on Saturday and continued until 8.00am in the Bhimbher sector.\nThe statement came after one of the worst episodes of cross-border firing by the Indians along the LoC, which left at least two Pakistan Army soldiers martyred last week. Analysts believe that the Indian government had staged the LoC violations to distract global attention from the brutalities being committed against the freedom-seeking people of the Indian-Occupied Kashmir (IOK). At least 120 innocent people have been martyred in the IOK since the killing of Kashmiri freedom activist Burhan Wani, while thousands of youths and children have been injured and blinded due to the use of pellet guns.\nSEEING IS BELIEVING:\n“We have never brought media to these forward locations at the LoC. Now you may see for yourself: No such occurrence has taken place as claimed by India. But if any such move is made in future, it will be responded to in a befitting manner,” General Bajwa told reporters after a detailed presentation made by the general officer commanding (GOC) of Bhimber sector.\nHe said that India should not be under any illusion that its forces can invade even an inch of Pakistani territory. He said Pakistani forces were capable of defending their territory and knew how to protect every inch of their motherland.\nReacting to the Indian claims, the DG ISPR pointed out that if anyone had crossed the LoC he would have been visible to someone in the valley. He also made an open offer to the journalists to go anywhere in the AJK to find facts over the Indian claim of “surgical attacks”. He said that army’s helicopters were ready to take any journalist willing to verify if the Indian army had entered the Pakistani territory.\nHe further said that in addition to allowing the local and international media to find facts in the AJK, Pakistan had also permitted the United Nations monitors to conduct fact-finding missions inside the AJK over the LoC violations\n“While we are allowing everyone to find facts, it is intriguing to note that India has neither allowed the media nor the United Nations monitors to go into the (Indian) Occupied Kashmir. What are they hiding from the world?” argued the DG ISPR.\nOn this occasion, the GOC also informed the journalists that no incident of intrusion by Indian army into the Pakistani territory had taken place on the night falling between September 28 and September 29 as claimed earlier by the Indian director general military operations (DGMO).\nIndia recently claimed of airdropping 150 commandoes into Azad Kashmir to launch “surgical strikes” early Wednesday night – a claim quickly rejected by Pakistan. Indian claim started to become suspicious soon afterwards, as the Indian government changed its initial claims with its Minister of State for Information and Broadcasting Rajyavardhan Singh Rathore telling Indian media that no aerial operations were involved in the attack.\nReferring to reports of an Indian soldier having entered into Pakistani territory “inadvertently”, Bajwa said the military was “looking into the matter”.\nAn Indian army official based in New Delhi said, “It is confirmed that one soldier from 37 Rashtriya Rifles with weapons has inadvertently crossed over to the Pakistani side of the Line of Control.” The Indian side demanded that he should be returned as per existing mechanisms. Pakistan’s Ambassador to the United Nations Dr Maleeha Lodhi has confirmed the arrest of the Indian soldier, saying he was captured “while trying to enter into the Pakistani territory”.", "label": "No"}
{"text": "This product can only be shipped to certain zip codes. View full details page for more information.\nmeets all my needs , it is after all just a mattress pad. seems to be of acceptable quality. perhaps in a year or so I could provide a better review. It remains to be seen how well it survives several washings and my teenagers abuse.", "label": "No"}
{"text": "Hey people... So did you guys here the newest huge scandal? Madonna and Guy Ritchie are officially getting a divorce. Isn't that crazy? I think it is. They seemed happy I guess but who knows what really happens behind closed doors?\nOn to more \"important\" things...\nThe Canadian election was yesterday and oh ho! surprise, surprise, the conservatives won. Well, I'm not even going to get into this because I want nothing to do with politics. The only reason I'm bringing it up is that the Decision 2008 aired when 90210 was supposed to play. ARGH! Evil people!! So I didn't get to watch my 90210 :( Oh well, next week then.\nHope all of you are having a good week. Some are doing midterms like I am right now and others are just enjoying work :P. Have a good one everyone!!\nFifth Harmony's \"Can You See\" - REACTING Live! - This new 5H song is from an upcoming animated movie. Will this be nominated for an Oscar? Watch and find out! Enjoy and SHARE!\n6 hours ago", "label": "No"}
{"text": "With €5m in Horizon 2020 funding, Enterprise Ireland has launched a new programme called Career-FIT in the hope of persuading 50 international researchers to Irish technology centres.\nHaving secured the funding under the programme, a total of 50 academics could be brought to work in Enterprise Ireland’s technology centres.\nThe purpose of the Career-FIT programme is to help fill the skills gap in some of the technology centres’ 482 member companies based in Ireland.\nExperienced researcher applicants taking part in the programme will work within market-focused applied research through three-year fellowships.\nUnder the Career-FIT programme, two calls will be issued to potential researchers, each of which will see 25 fellowships awarded.\nThe first call has an application deadline of 31 March, while the second call will open in 2018.\nSpeaking at the launch, jobs minister Mary Mitchell O’Connor said: “The Career-FIT programme is the first of its kind, addressing the skills shortage in industry-focused research in Irish technology centres.\n“This programme will benefit both the successful academic researchers and the Irish companies connected with the industry-focused technology centres.”\nEnterprise Ireland’s CEO Julie Sinnamon added: “Enterprise Ireland connects business and academic research to drive new innovative products, processes and services, helping Irish companies to develop a competitive edge in international markets.\n“The Career-FIT programme will facilitate the placement of 50 international academic experts in 13 technology centres, where they will work on industry-led research of direct relevance and value to Irish businesses.\n“The outputs of the collaboration will help Irish companies to build, scale and expand their reach in global market”.", "label": "No"}
{"text": "Joe Arrage at TSX\nTORONTO, June 7, 2022 /CNW/ – Joe Arrage, Chief Executive Officer, Clip Money Inc. (“Clip Money”, or the “Company”) (TSXV: CLIP) and their team joined Dani Lipkin, Director, Global Business Development, Toronto Stock Exchange, to celebrate the Company’s new listing on TSX Venture Exchange and close the market.\nClip Money, Inc. is an infrastructure enabled Fintech that enables businesses to make deposits quickly, easily, and securely to their current business bank account through a national network of drop box locations in malls, big box stores, and grocery chains.\nKindly CLICK HERE to watch video\nMore about the company and the concept", "label": "No"}
{"text": "If you are living in Saigon, and love Saigon as Saigonese, let ‘s make a beautiful Sunday be unforgettable, discover-able day. I loved Saigon at the first sight with noisy sound of Vintage Vespa bike, and from that, I discovered an antique market is hold in a hidden cafe shop every Sunday. It open from 7 am to noon, sometimes last to 3pm, but I suggest that you should come at about 8 am, enjoy coffee here and take a walk among the shop, and see the things which you can not find at another market but here.\nWith mixed-culture, antique things also are various . You can find the 60s’ vespa, lambretta bike from Italia or some ceramic pots, cup from Chinese Dynasty Times, or some Japanese clock. Of course there are something new but were designed to be antique. and sometime there are some fake things, most of them are watchs.\nYou can buy or just see, take photos and talk to seller. they all welcome you. the prices are not shown and you have to ask when you want to buy, and you can discuss for a cheaper price.\nAfter visiting market, you can move to Binh Duong, it takes about 1 hour ( 30km) and visit ceramic village with hundred ceramic factory. You see and talk to the people here, they will tell you how to make a perfect product. at the end, you will make a cup or something your self\nNot many foreigner tourist come to visit above places so I think it will be memorable trip to you. let’s try 1 time, to make your Sunday be a different day", "label": "No"}
{"text": "An Individual’s Quality of Life and Care guides our planning. We work with each person and/or their family with respect and dignity. We create legal and /or care solutions consistent with client’s priorities, usually involving:\n- appropriate living settings,\n- *property management,\n- property distribution,\n- care of other family member(s), and/or\n- incapacity planning.\n*Everything you have acquired, sold or distributed during your lifetime.\nAdvocate: Listen to Vulnerable Voice\nIntegrity: Compassion, faith based\nExcellence: All stages of planning, restoring client’s/family’s “peace of mind”\nTeam Focused: With clients, our firm & community\nResponse: Timely and clear", "label": "No"}
{"text": "01/10/2023 - 30/11/2023\nRegistration is now open for those wishing to apply for the Scottish Centre for Administrative Data Research (SCADR)'s online Introduction to Data Science for Administrative Data Research (IDS-ADR) course.\nThis four-week online course (approx. 5-6 hours per week) is delivered by experts in the field of administrative data research.\nThe course combines:\npre-recorded lectures (2-3 hrs per week) and\nweekly hands-on practical exercises using R-Studio to analyse synthetic admin data\nsupport with weekly practical exercises is available during weekly scheduled virtual lab sessions, with experienced tutors available to answer questions.\nCourse topics include: Introduction to administrative data and administrative data research; Legal and ethical contexts of admin data research; The public license and public engagement; Understanding data provenance; Introduction to programming & data manipulation verbs; Record linkage; Data visualisation; Analysing administrative data - methods, issues and challenges.\nNext course: October - November 2023\nCost: £120.00 per person\nFor more information and to register: https://edin.ac/3N7F0Fa", "label": "No"}
{"text": "The electronics titans square off in a tangled tale of mobile technology, centered on Apple's iPhone\nThe bipedal Schaft robot, the top scorer in a DARPA competition last year for disaster-response scenarios, will compete in the finals, but now with funding just from Google.\nThe Taiwanese manufacturer is reportedly helping to carry out Google's \"vision for robotics,\" and in return, Google will help the manufacturer deploy robotics in its factories.\nA robot made by a Japanese start-up that Google has bought has won a rescue competition organised by Darpa in the US.\nGoogle builds its robot fleet with another acquisition, Sprint may make a bid for T-Mobile, and Amazon sells Kindle Fire tablets on a payment plan.\nGoogle has confirmed it's acquired a company that makes robots for the military. But what's it planning?\nCompany nabs a maker of impressive walking and running creatures. It's part of Google's effort to buy its way into a future populated by autonomous mechanical entities.\nRich and Ashley recap Google I/O's keynote address, get weirded out by Japanese robots, and discuss stealth clothing.\nIt's a big episode today, filled with our Google I/O keynote recap, robot news anchors from Tokyo, the craziest privacy clothing yet, and, as always, your emails and tweets. Have you ever seen anything as fun and wacky as Google Cardboard? We haven't.\nDon't look for an Android-powered Wall-E anytime soon, but Google's recent move toward robotics signals a big momentum shift getting under way.\nThe former Android leader is in charge of one of Google's \"moonshots,\" an effort to use robots to free humans from drudgery.", "label": "No"}
{"text": "Taylor Swift basically broke the internet when she attended the Kansas City Chiefs game Sunday amid rumors that she may be dating the team's tight end Travis Kelce.\nThe pop star's presence was felt by fans, viewers, and pretty much anyone scrolling online as clips flooded social media and her attendance became the top trending search on Google.\nAnd while the Chiefs certainly had their heads in the game as they defeated the Chicago Bears in a 41 to 10 victory, they were still very much aware of a special fan in the stands.\n\"I heard she was in the house. I felt a little bit of pressure,\" Chiefs star quarterback Patrick Mahomes told reporters after the game.\nMahomes knew he had to get the ball to Kelce, who he said always gets creative with routes to find a way into the endzone. Kelce went on to do just that when he scored a touchdown in front of Swift, who watched the game from his glass-enclosed suite with his mom. She was seen cheering and yelling alongside his mother after the big score.\n\"I think he wanted to get in the endzone just as much as all the Swifties wanted him to,\" Mahomes said.\nLoving him was red, it seems, as Tay sported the team color along with her signature red lip.\nKelce has made a few grand gestures to get Swift's attention and invite her to his game. But if you ask Chiefs head coach Andy Reid, it's all because of him.\n\"You know what, I've met her before,\" the coach said. \"I set them up,\" Reid said as reporters laughed.\nThe official Twitter account for New Heights, a podcast hosted by Travis and his brother Jason Kelce of the Philadelphia Eagles, also poked fun at the matter.\n\"Gotta love when Mama Kelce brings her friends to the game,\" the show wrote on X, accompanied by a video of Swift cheering with mom Donna Kelce.\nVideos making rounds on social media showed Taylor cheering at various parts of the game, and she was even spotted cleaning up empty cups in the suite.\nRumors of Travis and Tay first started swirling when the footballer attended her Eras Tour concert in Kansas City. The singer performed on familiar territory at the Chiefs' Arrowhead Stadium. Kelce wanted to give Swift a friendship bracelet — which are popularly traded at her shows — with his phone number on it. But as the Kelce brothers joked about on their podcast, he was blocked from meeting her because she wasn't allowing visitors backstage before her shows.\nFast forward to an appearance on \"The Pat McAfee Show,\" and Kelce said he extended an invite to Swift.\n\"I threw the ball in her court and told her, 'I've seen you rock the stage in Arrowhead. You might have to come see me rock the stage in Arrowhead and see which one's a little more lit,\" Kelce said.\nLooks like the music icon was swift to accept.\nKelce did not sit for any post-game interviews, but he and Swift were seen leaving the stadium together.\n\"Entertainment Tonight\" reported that Kelce rented out a restaurant for a private party following the team's win.\n\"The two were very affectionate with one another but kept things fun and lighthearted,\" a witness told ET.\nTrending stories at Scrippsnews.com", "label": "No"}
{"text": "(3) Georgia Tech 57, (6) Boston Coll. 54\nMILWAUKEE (AP) -- The only thing Jarrett Jack could have done better was run out the clock.\nQuiet for most of the second half, Jack had a big steal and a breakaway dunk with less than six seconds left to help give Georgia Tech a 57-54 victory over Boston College in the NCAA tournament Sunday.\nThe third-seeded Yellow Jackets advanced to the regional semifinals for the first time since 1996. They'll play 10th-seeded Nevada, fresh off upsets of Gonzaga and Michigan State, on Friday in the St. Louis Regional.\n``This is the reason I came here,'' said Jack, a sophomore who was one of the top prep point guards in the country. ``This is the point we wanted to get the program back to.''\nJack finished with eight points, six rebounds and six assists. B.J. Elder led the Yellow Jackets (25-9) with 18 points, while Anthony McHenry scored 10.\nJared Dudley had 13 points for No. 6-seeded Boston College (24-10), but it wasn't enough to make up for the subpar performances of leading scorer Craig Smith and senior Uka Agbai. The two average more than 28 points a game, but they didn't come anywhere close to that after spending much of the day in foul trouble.\nSmith, who averaged 19.3 points and 11 rebounds in Boston College's first four postseason games, finished with just two points on 1-of-4 shooting. His only basket came with 5:15 left, and he fouled out with about 30 seconds left. Agbai had eight points, all in the final 15 minutes.\nThe Eagles also had 22 turnovers and were 9-of-15 from the free throw line.\n``They have a lot of athletes,'' Agbai said. ``They seem like a bunch of track stars out there. But it was our turnovers that led to a lot of those fast breaks.''\nStill, Boston College gave the Yellow Jackets everything they could handle.\nGeorgia Tech jumped out to an 11-point lead early in the second half and led by eight with 8:40 to play. But after Elder's 3-pointer with 6:01 left gave the Yellow Jackets a 53-48 lead, they didn't make another field goal until Jack's breakaway basket with about five seconds left.\nWith the Eagles trailing by one, freshman guard Steve Hailey tried to drive the ball inside, only to find Georgia Tech's 7-foot-1 center, Luke Schenscher, blocking his way. Hailey had no choice but to pass the ball, and Jack was right there to intercept it.\n``He had nothing else,'' Schenscher said. ``He had no other options, and Jarrett ... anticipated the play.''\nSaid Georgia Tech coach Paul Hewitt: ``We always talk about helping the helper. It's one of those times where what the coach tells you sticks in your head.''\nJack grabbed the ball and, with Georgia Tech fans screaming, took it down for a thunderous dunk. It was his first bucket since three minutes into the second half.\n``It was a great play,'' McHenry said. ``I told him I wish he would have run the clock out, but it was good.''\nHewitt tried to tell Jack to dribble out the clock, but he couldn't hear because of the crowd noise.\n``I didn't know how close anyone was,'' Jack said. ``So I thought I might as well go in and get the easy two and get a three-point lead.''\nIt left Boston College one last chance, but Jermaine Watson's 3-point attempt skidded around the rim before falling off at the buzzer.\n``He had a good look,'' Dudley said. ``Jermaine will knock that down nine out of 10 times. It just didn't fall that time.''\nThe schools' first meeting since the second round of the 1996 NCAA tournament -- Georgia Tech won that one, too -- was supposed to be a defensive battle. The Yellow Jackets limit opponents to less than 39 percent shooting, while Boston College is right around the 40 percent mark.\nBut while each team harassed the other, stuck hands in faces and generally made a nuisance of itself, both shot better than 48 percent. Georgia Tech even made its first six shots on its way to an early 16-5 lead.\nAn 18-6 run spanning halftime gave the Yellow Jackets a 44-33 lead with 16:15 left. But Boston College refused to go quietly, tying the game at 53 on Dudley's 3-pointer with 2:48 left.\n``You can't tell me when we were down double digits in the second half that anyone thought we'd have a one-point lead with 30 seconds to go,'' Boston College coach Al Skinner said. ``We put ourselves in position to win, and that's all you can ask.''", "label": "No"}
{"text": "How many times a day do you search for an answer on Google?\nIt’s become such a normal reaction that we hardly notice we’re doing it.\nIf you have a question, chances are Google has the answer.\nNot only that, but it will pair you with the best, most accurate answer while giving you access to thousands of other results. Knowing this causes us to trust Google and come back to its search engine again and again.\nSince we are commonly searching for products, services, and information on Google, we know other people in our audience are doing the same.\nUnderstanding how search engines work is one of the best investments we can make in our business because many purchases start with a simple search.\nWhat is SEM (search engine marketing)?\nWhen a user comes to Google, they type their search query into the search bar. This is usually a line of keywords or a question that describes what they’re looking for. Google also offers potential search results as the user types their search query so they can get to their results even faster.\nBy optimizing your SEM (search engine marketing) strategy, you’re able to capture the attention of people who already are interested in what you offer.\nNaturally, it’s easier to persuade someone who already has some interest in what we do to buy something than someone who is browsing for other things. This is why search engine marketing is so powerful. By understanding the person’s search intent, Google is able to pair its users with websites (like yours) that will provide relevant answers.\nGoogle primarily does this in two key ways. It uses SEO (search engine optimization) to help us produce organic, unpaid traffic and PPC (pay-per-click) advertising to produce paid, targeted traffic.\nSEO vs PPC\nInstead of asking yourself if you should use SEO or PPC marketing tactics, you can utilize both in your strategy. They work best when they’re able to work together to accomplish your bigger search engine marketing goals.\nYour first decision is to determine how much effort you want to put into each one. Let’s walk through what’s involved in each SEM tactic so you know how to use them to your advantage.\nWhy online entrepreneurs should care about SEO\nAs digital business owners, most of us do the bulk of our marketing and selling online. Optimizing our websites with healthy SEO tactics is one of the best things we can do to build long-term success for our business.\nThe hard thing about SEO is that your website won’t pop up to the first page of Google overnight. That’s what we’re all shooting for since 75% of visitors choose a result from the first page, but as new entrepreneurs, we can’t expect to publish our website and rank well the next day.\nDepending on the competition of the keywords you’re using, meaning how many people are trying to rank on Google for the same terms, it can take years or even decades to build your website to a place where you reach the top of the first page. But don’t let that deter you from focusing on SEO!\nThat’s why we want to stress how important it is to approach SEO from a long-term perspective. While you may have a long road ahead of you before you pop up as a preferred result, there are simple tweaks you can make today to improve your SEO.\nThe first place to start is by optimizing the headlines, titles, meta descriptions, and image alt tags on your website. This allows you place relevant keywords throughout your website and optimize specific website pages for your intended audience. You can learn more about how to do this inside our in-depth SEO-friendly content article.\nOnce you’ve optimized your on-page SEO, you can focus on what we call off-page SEO. On-page SEO is characterized by the things you can change on your own website. Off-page SEO, however, is determined by how your website works in relation to other websites.\nOne of the best ways to start building good off-page SEO is by link building. When you create valuable blog content on your website, other website creators may be interested in linking to your content within their blog posts.\nThis tells Google that your website is a more trusted source on the topic because other high-quality websites are linking to your website. You can learn more about off-page SEO techniques here.\nSEO is a long-term process in itself, so instead of feeling like you have to optimize everything all at once, focus on a few factors at a time so you can see how it affects your search performance. Then you can easily set SEO goals and track them within Google Analytics.\nWhen online businesses should invest in PPC advertising\nWe’ve talked a lot about SEO so far but what about PPC advertising? You might be wondering why you’d want to pay for traffic with PPC ads when you could generate free, organic traffic through SEO.\nRemember that SEO is a long-game optimization tactic, so if you’re interested in generating quick sales and gaining customer feedback, PPC ads could be a great option. Also, people who click on PPC ads are more likely to convert and buy from you than people who visit your site organically, so it’s worth looking into.\nEven if you’ve never heard of PPC ads before, you’ve definitely seen them on Google. They are usually displayed above the organic search results at the top of the search engine results page (SERP). Google will usually show up to four ads at the top with a green “Ad” box by the URL.\nCompanies of virtually any size (yes, even solo entrepreneurs!) can use PPC ads to sell their products, services, or convert visitors into email subscribers.\nBefore you create a PPC ad campaign, it’s important to set a central goal for what you are hoping to accomplish. Then you can make sure that your one CTA strongly relates with your goal so your visitors are perfectly primed for what you are selling.\nKeep in mind that when you decide which keywords to use in your targeted ad, some are more expensive than others. Why is this? Some searches are considered more competitive.\nProfessionals like insurance agents and attorneys have to shell out more cash for their PPC ads than entrepreneurs in other industries do because there’s so much more competition. You can make your ads less competitive by being specific about your location, audience demographics, and including more specific keywords, but you still might be charged more than on other platforms.\nRemember that you pay for every click, not every sale. Google doesn’t charge you for showing your ad at the top of the screen but just because a user clicks on your ad doesn’t mean they are going to buy from you. This is why you need a bigger SEM strategy so you are spending advertising dollars wisely.\nHow does SEO and SEM work?\nSpeaking of your SEM strategy, this is the first place we will start. Instead of treating your PPC and SEO marketing strategies differently, you’ll want to create them together to enhance your overall marketing plan. (Google recommends a holistic approach to SEM marketing too!)\nYour SEM strategy needs to define…\nYour SEM goals:\nYour goals will be influenced by:\n- How new your website and domain name is\n- What your budget spend looks like\n- How often you want to optimize your website and run ads\nIf you just launched your website, you may rely more heavily on PPC ads to grow your email list or product sales while you build foundational SEO tactics.\nIf your paid acquisition budget fluctuates, you may want to experiment with PPC ads and other social media ad platforms to see which yields the best return.\nYour SEM metrics:\nBefore you create a PPC ad or put hours into your SEO efforts, you’ll want to determine the best way to measure your success. Without metrics, you won’t know what tactics are the best use of your time. Since time is our most valuable resource, we want to use it wisely.\nKnowing what tools you want to use to track your PPC and SEO progress is a great first step in understand which SEM metrics will be most beneficial to your business.\nYour CTA for PPC ads:\nOnce you have a primary goal and metrics in mind, you can create a call-to-action that is clear, concise, and resonates with your audience.\nIf your main goal is to attract more email subscribers, then your PPC ad CTA should be centered around signing up for a lead magnet. If you’d rather get more people to join your waitlist for a new coaching program or apply to be considered, then the CTA should be to click on the link and sign up on the landing page.\nOnce you’ve gone through and defined your SEM strategy, you can put it into action by implementing the goals you’ve set for yourself. Since you’re building from a solid foundation, you’ll be ready to focus on executing.\nWe talked about this when explaining the basics of on-page SEO, but let’s go beyond optimizing titles and meta descriptions with some additional recommendations. These actions can include:\n- Using logical website architecture with user-friendly navigation\n- Creating understandable sitemaps for users and search engines\n- Including an easy-to-use search functionality for users\n- Checking for broken links within your own website\n- Assessing how well your website loads on all devices\n- Including concise but descriptive page links with relevant keywords\n- Internal linking to relevant pages within your own website\n- Making sure every website page has a direct CTA\n- Creating a custom 404 page to direct users to another part of your website\n- Great user interface (UI) and user experience (UX)\nYou can use this as a checklist and take these tasks one at a time. Even if you took a weekend to optimize each of the areas, you’d be well on your way to creating a more valuable, SEO-friendly website in a few short months.\nKeywords, although sometimes highly competitive, can be one of the most crucial ways to optimize your website and paid ads. When you niche down your products and services, it becomes easier to find keywords that are a fit for your target audience.\nYou can start doing keyword research and implementing them into your website pages and blog posts. If you decide to do PPC advertising, you’ll also want to use these keywords in your ad copy and let them influence your ad targeting options.\nThe more engaging your content is, the more likely visitors will be to stick around. This will lower your bounce rate, which refers to the amount of people who leave your website after viewing only one page. Google prioritizes websites with low bounce rates because it shows that the content the website creator produces is valuable enough to their audience for them to stay.\nA great way to start creating valuable content is by writing long-form blog posts or embedding video content into your blog posts. Create content around topics your audience is interested in and or email questions that pour in through social media and your inbox. This is sure to help your SEO ranking.\nGoogle-based SEM goes well beyond SEO and PPC advertising. It also offers other features that help you track your performance and get your brand in front of new eyes.\nGoogle My Business can be used to help local visitors find your website. Even if you don’t have a brick-and-mortar store, you can still use a Google My Business page to collect Google Reviews and help you pop up quicker on the first page of Google for long tail keywords. It’s easy to sign up and anyone with a registered business can utilize this tool.\nGoogle also released their Google Merchant Center which allows retailers and brands to get their products in front of all kinds of buyers. It’s another online marketplace option that may help you increase your product sales. You can simply create a Google Adwords campaign and create a Google Merchant based ad that shows a photo thumbnail of your product with a buy now action\nGet started with your SEO and SEM strategy today!\nHow do you envision your PPC and SEO strategies working together? What are you putting a bigger emphasis on right now?", "label": "No"}
{"text": "Where Is The Casino In Casino Royale\nView deals for Best Western Plus Casino Royale - Center Strip, including fully refundable rates with free cancellation. Guests enjoy the locale. So. Popular culture. Casino Royale is the first novel by the British author Ian Fleming.Published in 1953, it is the first James Bond book, and it paved the way for a further eleven novels and two short story collections by Fleming, followed by numerous continuation Bond novels by other authors Casino Royale is the 21st entry in the official James Bond film series and marked the debut of Daniel Craig as Agent 007. Directed by Martin Campbell. 4. Both variations are a modified rumble rules battle royal.The Casino Battle Royale features 21 entrants, while the Casino Tag Team Royale features 15 tag teams (totaling 30 wrestlers) Herb Alpert y la Tijuana Brass interpretan 'Casino royale theme (el tema de Casino Royal), publicado como sencillo en 1967. 8. Why doesn't Vesper give Bond the additional $5M? The dining options are limited BEST WESTERN PLUS Casino Royale, 3411 Las Vegas Blvd. Fue compuesto por Burt Bacharach.2.. Casino Royale is a 2006 spy where is the casino in casino royale film, the twenty-first in the Eon Productions James Bond series, and the third screen adaptation of Ian Fleming's 1953 novel of the same name.Directed by Martin Campbell and written by Neil Purvis, Robert Wade and Paul Haggis, it is the first film to star Daniel Craig as the fictional MI6 agent James Bond, and was produced by Eon Productions for Metro-Goldwyn-Mayer.", "label": "No"}
{"text": "7*24 Hours For You\nStone crushers chimakurthy.Stone crushers in chimakurthy - dietisthoofddorp.Srinivasa stone crusher in chimakurthy - evenementciel.Stone crushers in chimakurthy area 04 line crushing line in algeria algeria is one of the most important markets in africa we have set up an overseas, read more contact line grinding in belgium in get price.Get Latest Price\nOur products sell well all over the world, and have advanced technology in the field of crushing sand grinding powder.\nCrushers in chimakurthy stone crushers in prakasam district importance of chimakurthy andhra pradesh for stone crusher description global stone crushers srinivasa stone crusher in chimakurthy i have been paying monthly bribe to ongole rto agent nageswar 25 jan 2014 i am a 10tyre tipper owner from chimakurthy read more.\nGlobal stone crushers ongole kolaedu.Crushers in chimakurthy.Global stone crushers in ongoleandhra pradeshindia company.Global stone crushers is a leading manufacturer amp crushers global stone crushers, ongole grinding mill china.Iems filed,lawyerpet, ongole,prakasam andhra pradesh 523 002 nu telephone fax 30 trv global exports pvt.\nSrinivasa stone crusher in chimakurthy.Chimakurthy granite all quarry names kaolin equipment suppliers chimakurthy granite all quarry names vibrating sieve separator stone crushers in chimakurthy binqcrusher net the black galaxy quarry is located in the village of chimakurthy in the state of andhra pradesh and now chimakurthy granite processing crushers in chimakurthy read more.\nChimakurthy stone crushers.Indian black galaxy granite stone supplierlack galaxy granite is a kind of basic plutonic intrusive rocks,deep black color,mainly by the content of the basic equivalent of orthopyroxene and basic plagioclasee golden sands is called bronzite minerale black galaxy granite quarry located in chimakurthy,ongole,indian.\nBased on the strategy of localization service, lxp has set 22 overseas offices.If you have any questions, you can make connections with nearby office directly.\nStone crushers chimakurthybirlafinance.Stone crushers in chimakurthy stone crushers is the main mining equipments in kenya used for crushing fluorspar limestone gemstones stone crushers.\nStone crushers in chimakurthy.Stone crushers in chimakurthy area 20170904 lizenithne crushing line in algeria algeria is one of the most important markets in africa we have set up an overseas read more contact lizenithne grinding in belgium in modern contact supplier stone crusher in chimakurthy.\nSajeevan is a the setting up of stone crushers in the valley in tak stone crusher narath kannur previous post trituradora de piedra indiagranite.Learn more quarry machine and crusher plant sale in palakkad kerala granite quarry for sale in palakkad used mobile crushers for sale uk stone crushing.\nArunodaya stone crusher chimakurthy arunodaya stone crusher chimakurthy - 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{"text": "Forestry & Forest Products Research Centre, University of KwaZulu-Natal\nBruce Sithole is a Principal Researcher and Director, Forestry & Forest Products Research Centre, University of KwaZulu-Natal/Council for Scientific and Industrial Research, Durban. He is an honorary professor in Chemical Engineering at UKZN where he supervises MSc and PhD students working on biorefinery topics, cellulose chemistry, and pulp and papermaking technologies. His main research focus is on development and implementation of biorefinery technologies, specifically those aimed at beneficiation of forestry, pulp and paper mill wastes. The purpose of the research is to contribute to the revitalization and resilience of the pulp and paper industry by diversifying into biorefinery activities that will add more value to the bottom lines of the mills. He was previously with the Pulp and Paper Research Institute of Canada where he worked on R&DI on pulp and papermaking technologies.\n- BSc (hons), chemistry, University of Sierra Leone\n- MSc, chemistry, University of Aberdeen\n- PhD, Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada\n- NRF rated scientist\n- Publications: Over 90 publications in peer-reviewed journals.", "label": "No"}
{"text": "What is Life?\nShema Abdul Wahid\nSometimes, I become compelled to set alone in order to know the definition of life, but I always get disappointed by being failed again and again because everyone has their own thoughts and views regarding life.Some of them told “life is the name of compromising”,some told “It’s the name of conclusion”and even half of them told, “life is the second name of death because where there is life,we can find the step of death, but life is nothing more than a journey with lots of lessons, hardships,special moments and challenges.Owing to these challenges, life is so complicated.Neither it can be understood nor someone is there to explain what life is actually.And death is the painful reality of life which is not the end of it rather it starts from it. Furthermore, life is a continuous ongoing process that has to end someday.Life is all about adoring yourself and creating yourself.A quote for you is that life can be only understood backward but it must be lived forwords.Life itself is a golden opportunity to live a meaningful life and supports other to do so.It doesn’t matter how many years you live, but it matters how will you live a quality life.The fear of death always threatens our lives.Every person has to face the death sooner or later,but it doesn’t mean it should discourage us from living the life to the fullest or achieving our goals.It is a journey in everyone’s life where as we have to cross the bridge of death to be able to wake up to a life eternal.Life will automatically lead us towards our destination, our purpose.However, we have to face challenges and these challenges will always test our courage, strength, weaknesses and faith.Life is not all about proving anyone wrong rather it’s about proving yourself right.Luck is great, but most of us life is hard work.Many times, we face challenges and struggle happens to help or teach us the lesson.What’s really important is who you become through all of life’s challenges. On the other hand, life is full of ups and down.We all experience difficulties in our lives.You may be experiencing the death of your beloved ones and lossing or hurting your loved ones is to a life change.Sometimes life isn’t what you want it to be.Therefore, difficult times are the part of our life story.Hard times can mean different things to different people.And coping with difficult time is not easy.But as the adge goes ,which doesn’t break you, rather makes you stronger.Each time you edsure a difficult time in your life, ,you build personal character.And it is the character that will carry you towards the good times to come and give you more strength for the next time.Yoy experience a tough period of life.Difficult times help you to grow up into a more well-rounded and mature who is more capable of handling the ups and down in life. It’s no denying the fact that life is not all about being perfect rather it’s about being happy.Not all the time ,but anytime you can.Most importantly, you are a miracle, this world is a blessing, life is a miracle.life is really what you make it.To be happy, to find happiness no matters what life throws at you.Live everyday like you are blessed.Live everyday as if you are grateful to simply be alive.Be happy ,no matters what happens and life will be amazing itself.Don’t think about past, it has gone.Don’t be worried about future ,it isn’t a arrive.Just be in present and make it beautiful.Sometimes, life acts strangely because at some point , it gives thousands of reason to human to stay alive and other point it even doesn’t give a single reason to human being to peruse their breathing,but still it flys like a bird and goes on until it is thrown by a strOng wind.Indeed,life gets strange,heartbreaking and breathtaking but life goes on, it has to go on..Everyone face ups and down ,but miseries are covered by a thin veil hope for ray.Hope is the mOst important part in the life of a person when she/he is in darkness.It is only hope which encourage everyone to carry the burden on cruel life.In a nutshell,life can’t be define easily because everyone has different purposes, miscellaneous goals, faces different challenges and most importantly achieve different success.We have to embrace the hard realties of life in order to live the life the way we want. So,live the life, you love and love the life,you live.Everyone should enjoy each and every moment of this life because life is dependent on one breath which can be finish in one second and it is not known when it will take you with itself.Thus,live for your own self.In addition, life is the combination of special moments, worst event, happines, sorrows, hardships and many more, but it’s up to us to make it what.Whether to live it the way we want or lead us towards the way of destruction.Love you life.Really you are tough but enjoying you has its own twist because life gets tough but we are tougher. “Zindagi Tujhe Salam”", "label": "No"}
{"text": "News from 2008\nPublished October 23, 2008 in Press Releases\nPolarLake has today announced that it has joined the EDM council, the not-for-profit business forum for financial institutions concerned with Enterprise Data Management.\nPublished July 3, 2008 in Press Releases\nPolarLake has today launched a standalone Reference Data Reconciliation solution dedicated to fixing the problem of poor reference data quality in downstream systems. The solution allows the organization to reconcile its centralized Golden Copy with the distributed copies of reference data in the downstream systems.\nPublished March 17, 2008 in Press Releases\nPolarLake and AIB Bank today announce that PolarLake has been chosen as the central integration and data distribution technology for AIB’s core Banking replacement programme in Ireland and the UK. Working with i-flex® FLEXCUBE® and IBM® WebSphere® on the IBM System z™ mainframe platform, PolarLake will be used to enable a seamless transition from the older core Banking applications to the new i-flex system. PolarLake will also enable the channel applications (Branch, Internet, ATM and Call Centre) to be hidden from the complexity of the core Banking transition.\nPublished March 11, 2008 in Press Releases\nPolarLake announced the release of PolarLake RDD v3.0. Based on extensive experience in the field with complex Reference Data Distribution projects and customer feedback, the latest PolarLake RDD delivers massive enhancements in Business Operations support, Business Analyst usability and system performance and scalability.\nPage 1 of 1", "label": "No"}
{"text": "|US Release Date||03/21/2001|\nMike Leigh, Pedro Almodovar and Wim Wenders are among the European filmmakers who are appealing to Russian leader Vladimir Putin for the release of jailed Ukrainian director Oleg Sentsov.\nYou gotta love (and hate) that damn pizza man.\nYou know you've been waiting for a Franz Kafka videogame.\n'Ever, Jane' reached its Kickstarter funding goal on Monday.\nSyFy has announced that a 'Sharknado' sequel is in the works, and fans will get to name it on Twitter.\nSyfy's ambitious 'Defiance,' a multi-media TV series and online game project, gets a second season, while 'Cougar Town's Bill Lawrence has his third show of the day, 'Ground Floor' at TBS, picked up to series.\nSony's unveiling of the new console is heavy on extras, light on actual gameplay.\nCatch up before an all-new 'Supernatural' tonight!\nIt may be about crime, but this show is quite humerus.\n'Defiance' is the future of transmedia entertainment.\nForget Demi and Ashton. These celebrity spouses have some major age differences.", "label": "No"}
{"text": "It appears, for their sophomore effort Stars Aligned, Finland's Stargazery fell back on the old adage, \"If it ain't broke, don't fix it.\" Then added another American word of wisdom: \"Go big or go home.\"\nIn this sense, first, Stargazery has stuck to their formula of classic mid-Eighties melodic hard rock with a metal edge. As I said about their debut album, they sound a bit like latter period Rainbow, only with the keyboards at the forefront more often. To the latter adage, these keyboards seem even more grand and encompassing. The riffs as well, and when put together, Stars Aligned has monsterous bombastic sound. Yet, groove, melody, and vocal harmony are never lost. Everything's just larger. Good examples of the more ambitious keys and guitar come with Bring Me The Night, Missed the Train to Paradise, and Painted Into A Corner, where the keyboards have an old school flair at the conclusion. While this motif abounds throughout, perhaps the best example comes with Stargazery covers Cher's Dark Lady. They easily trump the pomp of the original, and for their homeland fans they offer a Finnish version as a bonus track. Fundamentally, Stargazery's Stars Aligned is all very engaging, entertaining and, often, seriously over the top, metal-edged melodic hard rock. Recommended.\nFundamentally, Stargazery's Stars Aligned is all very engaging, entertaining and, often, seriously over the top, metal-edged melodic hard rock. Recommended.\nMat Sinner is both an icon and legend in the German, and the larger European, hard rock and heavy metal scene. Cranking out music since 1982, Sinner is an industrious and prolific musician and producer whether through his namesake band, the heavy metal heroes Primal ... [ Read More ]", "label": "No"}
{"text": "Multi-look, all in one palette allows you to create a fresh and light nude look for day or a sophisticated, vibrant look for evening.\nIncludes: 1 Diorific illuminating powder for face, 1 Diorblush vibrant colour powder blush, 6 eyeshadows, and 2 Dior Addict Ultra-Gloss.\nCreate an account with us and you'll be able to:\nFill in your email below to request a new password. An email will be sent to the address below containing a link to verify your email address.", "label": "No"}
{"text": "This exclusive brand embodies top quality durability cutting edge design and features. These have 40% extra lining than other brands on the market the extra lining is in the hip area and down along shin area they have a Dupont™ Kevlar® Fibre Protective Lining in complete back side area hip area and knee and shin area\nProduced in stretch denim for greater comfort especially in the riding position.\nThese jeans has pockets for optional hip and knee protectors\nThere are no rivets on these pants which could scratch the bike. Regarding the fit, these jeans are so called straight fit: slim legs with a tapered fit.\nComposition: Shell 100% cotton\n|Brand||Bikers Gear Australia|\n|Unit Of Measure||ea|\nOthers Also Bought\nMore From This Category", "label": "No"}
{"text": "LITERARY festival Ways With Words makes a welcome return on the Dartington Hall Estate from July 8 after a two-year absence.\nAs ever, the 10-day festival is bringing together a fantastic line-up of writers, speakers, politic minds, scientists and more to take to the stage in the Great Hall and across other venues on the estate.\nWhat started life as a seven-day festival at Dartington Hall near Totnes has flourished into three annual festivals across the UK, bringing enormous joy to many people.\nSo when the covid-19 pandemic hit, the loss of Ways With Words was felt by guests from Devon to the Lake District.\nDiscussions of new ideas had to be halted and the profound impact of the lockdown restrictions were felt across the entire arts sector.\nDespite this, physical distancing has shown all of us how much we need and value the arts and Ways With Words is delighted to be back at Darlington in full capacity.\nIncluded in the impressive line-up of 50-plus speakers are Joanne Harris, Salley Vickers, Alan Johnson, Delia Smith, George Monbiot, Roger McGough, Patrick Barkham, Steve Richards, Alison Weir, Catherine Pepinster, John Crace, Martin Sixsmith, David Owen, and Tracy Borman.\nAnd once again audiences will be able to explore history and politics, unpick pressing global issues, discover the wonders of science, nature and the environment, and travel around the world – all in the glorious surroundings of the Dartington Estate.\n(Contributed by Ways With Words ) (Contributed by Ways With Words)\nReturning hasn’t been an easy matter, however, like many other arts organisations, Ways With Words continues to recover from the hardship caused by the pandemic.\nThe cost of living is rising and covid leaves uncertainty in the air as many guests ponder their return to the festival.\n‘It was touch and go, but the superhuman efforts of managing director, Leah Varnell, has made it possible for Ways With Words to emerge into a post-pandemic world,’ said festival founders Kay Dunbar and Stephen Bristow.\n‘We hope that everyone who attends the festival will leave feeling restored, nourished and revitalised by the wealth of words and ideas on offer. It is vital that people continue to support the festival and secure its future.’\nAfter 30 years of hard work, Kay and Stephen felt it was time to put their feet up.\nIn February 2019 Leah Varnell, who previously had been the general manager and festival curator, took over as managing director with responsibility for the future of Ways With Words.\nAnd Leah shares the same excitement of the founders as the festival approaches.\n‘It has been a really challenging few years at Ways With Words but we are delighted to be back in full force to celebrate our 30th anniversary,’ she said.\n‘We’re hoping to welcome back lots of guests , both new and old, but we are by no way means out of the woods as an arts organisation.\n‘The future remains precarious but we will do we all we can to ensure Ways With Words is here for another 30 years.’\nGeneral booking for Ways With Words is now open and the fastest way to book your tickets will be online at wayswithwords.co.uk,.\nAdditionally tickets can be booked over the phone, from 11am to 4pm Monday to Friday, by calling 01803 867373.", "label": "No"}
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{"text": "I am a motivated, young and passionate interior architect.\nMy experience comes from various projects accomplished on a private and professional scale. Interior architecture and design are skills I have learned troughout my studies, many internships around the world and, for almost four years now, as a full time occupation.\nNew experiences are always more than welcome, I am not deterred by challenges!\nDo not hesitate to contact me.", "label": "No"}