“Another way to talk”: Photo-stories to promote safe disclosure among people with HIV
Participants photographed meaningful aspects of their lives with HIV; shared pictures in small group and individual discussion sessions, and; chose pictures and captions to display in clinic and community exhibits. To assess the relationship between the project and disclosure, we analyzed session transcripts and 300 photographs using theme analysis strategies.
38 PWH in four cities in the Midwest and Northeast U.S took part in the project. Disclosure was a prominent topic in all group and individual sessions. Disclosure related images included sources of social support, HIV medicines, and symbols of disclosure emotions, among others. Data analysis revealed three categories of participant disclosures to others – fearful, reluctant, and open. The project supported all disclosure types – helping fearful participants manage their emotions, reluctant participants plan for more effective disclosures, and open participants share their HIV status.
Pilot findings suggest that photo-stories can be further developed as a safe and powerful disclosure intervention strategy to improve disclosure and subsequent health outcomes among PLH as well as help clinicians discuss disclosure with patients. The process is acceptable to PWH at all stages of their HIV experience. Processing their life experiences creatively helps PWH problem solve disclosure challenges and celebrate successes.
Learning Areas:Diversity and culture
Implementation of health education strategies, interventions and programs
Public health or related research
Social and behavioral sciences
Demonstrate the importance of innovative interventions to promote safe disclosure of HIV status among people living with HIV Discuss how photo-stories are a potentially efficacious disclosure intervention Explain the implications for future disclosure interventions
Keyword(s): HIV Interventions, HIV Risk Behavior
Qualified on the content I am responsible for because: I am the study PI. I designed, implemented, and evaluated study data.
Any relevant financial relationships? No
I agree to comply with the American Public Health Association Conflict of Interest and Commercial Support Guidelines, and to disclose to the participants any off-label or experimental uses of a commercial product or service discussed in my presentation.


The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.
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RATIONALE - The rapid induction and orchestration of new blood vessels are critical for tissue repair in response to injury, such as myocardial infarction, and for physiological angiogenic responses, such as embryonic development and exercise.
OBJECTIVE - We aimed to identify and characterize microRNAs (miR) that regulate pathological and physiological angiogenesis.
METHODS AND RESULTS - We show that miR-26a regulates pathological and physiological angiogenesis by targeting endothelial cell (EC) bone morphogenic protein/SMAD1 signaling in vitro and in vivo. MiR-26a expression is increased in a model of acute myocardial infarction in mice and in human subjects with acute coronary syndromes. Ectopic expression of miR-26a markedly induced EC cycle arrest and inhibited EC migration, sprouting angiogenesis, and network tube formation in matrigel, whereas blockade of miR-26a had the opposite effects. Mechanistic studies demonstrate that miR-26a inhibits the bone morphogenic protein/SMAD1 signaling pathway in ECs by binding to the SMAD1 3'-untranslated region, an effect that decreased expression of Id1 and increased p21(WAF/CIP) and p27. In zebrafish, miR-26a overexpression inhibited formation of the caudal vein plexus, a bone morphogenic protein-responsive process, an effect rescued by ectopic SMAD1 expression. In mice, miR-26a overexpression inhibited EC SMAD1 expression and exercise-induced angiogenesis. Furthermore, systemic intravenous administration of an miR-26a inhibitor, locked nucleic acid-anti-miR-26a, increased SMAD1 expression and rapidly induced robust angiogenesis within 2 days, an effect associated with reduced myocardial infarct size and improved heart function.
CONCLUSIONS - These findings establish miR-26a as a regulator of bone morphogenic protein/SMAD1-mediated EC angiogenic responses, and that manipulating miR-26a expression could provide a new target for rapid angiogenic therapy in ischemic disease states.
Bone Morphogenetic Proteins (BMPs) are secreted cytokines that are part of the Transforming Growth Factor β (TGFβ) superfamily. BMPs have been shown to be highly expressed in human breast cancers, and loss of BMP signaling in mammary carcinomas has been shown to accelerate metastases. Interestingly, other work has indicated that stimulation of dermal fibroblasts with BMP can enhance secretion of pro-tumorigenic factors. Furthermore, treatment of carcinoma-associated fibroblasts (CAFs) derived from a mouse prostate carcinoma with BMP4 was shown to stimulate angiogenesis. We sought to determine the effect of BMP treatment on mammary fibroblasts. A large number of secreted pro-inflammatory cytokines and matrix-metallo proteases (MMPs) were found to be upregulated in response to BMP4 treatment. Fibroblasts that were stimulated with BMP4 were found to enhance mammary carcinoma cell invasion, and these effects were inhibited by a BMP receptor kinase antagonist. Treatment with BMP in turn elevated pro-tumorigenic secreted factors such as IL-6 and MMP-3. These experiments demonstrate that BMP may stimulate tumor progression within the tumor microenvironment.
In mouse and human neural progenitor and glioblastoma "stem-like" cells, we identified key targets of the Polycomb-group protein BMI1 by combining ChIP-seq with in vivo RNAi screening. We discovered that Bmi1 is important in the cellular response to the transforming growth factor-β/bone morphogenetic protein (TGF-β/BMP) and endoplasmic reticulum (ER) stress pathways, in part converging on the Atf3 transcriptional repressor. We show that Atf3 is a tumor-suppressor gene inactivated in human glioblastoma multiforme together with Cbx7 and a few other candidates. Acting downstream of the ER stress and BMP pathways, ATF3 binds to cell-type-specific accessible chromatin preloaded with AP1 and participates in the inhibition of critical oncogenic networks. Our data support the feasibility of combining ChIP-seq and RNAi screens in solid tumors and highlight multiple p16(INK4a)/p19(ARF)-independent functions for Bmi1 in development and cancer.
Copyright © 2013 Elsevier Inc. All rights reserved.
BACKGROUND - Anemia is a common complication of chronic kidney disease (CKD) that negatively impacts the quality of life and is associated with numerous adverse outcomes. Excess levels of the iron regulatory hormone hepcidin are thought to contribute to anemia in CKD patients by decreasing iron availability from the diet and from body stores. Adenine treatment in rats has been proposed as an animal model of anemia of CKD with high hepcidin levels that mirrors the condition in human patients.
METHODS - We developed a modified adenine-induced kidney disease model with a higher survival rate than previously reported models, while maintaining persistent kidney disease and anemia. We then tested whether the small molecule bone morphogenetic protein (BMP) inhibitor LDN-193189, which was previously shown to lower hepcidin levels in rodents, mobilized iron into the plasma and improved iron-restricted erythropoiesis in this model.
RESULTS - Adenine-treated rats exhibited increased hepatic hepcidin mRNA, decreased serum iron, increased spleen iron content, low hemoglobin (Hb) and inappropriately low erythropoietin (EPO) levels relative to the degree of anemia. LDN-193189 administration to adenine-treated rats lowered hepatic hepcidin mRNA, mobilized stored iron into plasma and increased Hb content of reticulocytes.
CONCLUSIONS - Our data suggest that hepcidin lowering agents may provide a new therapeutic strategy to improve iron availability for erythropoiesis in CKD.
Atrial fibrillation (AF) is the most common cardiac arrhythmia and carries a significant risk of stroke and heart failure. The molecular etiologies of AF are poorly understood, leaving patients with limited therapeutic options. AF has been recognized as an inherited disease in almost 30% of patient cases. However, few genetic loci have been identified and the mechanisms linking genetic variants to AF susceptibility remain unclear. By sequencing 193 probands with lone AF, we identified a Q76E variant within the coding sequence of the bone morphogenetic protein (BMP) antagonist gremlin-2 (GREM2) that increases its inhibitory activity. Functional modeling in zebrafish revealed that, through regulation of BMP signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development. GREM2 overactivity results in slower cardiac contraction rates in zebrafish, and induction of previously identified AF candidate genes encoding connexin-40, sarcolipin and atrial natriuretic peptide in differentiated mouse embryonic stem cells. By live heart imaging in zebrafish overexpressing wild-type or variant GREM2, we found abnormal contraction velocity specifically in atrial cardiomyocytes. These results implicate, for the first time, regulators of BMP signaling in human AF, providing mechanistic insights into the pathogenesis of the disease and identifying potential new therapeutic targets.
Juvenile ischemic osteonecrosis of the femoral head (IOFH) is one of the most serious hip conditions causing the femoral head deformity. Little is known about BMP signaling following ischemic osteonecrosis. In this study, we found acute BMP2 upregulation in the femoral head cartilage 24h after ischemic induction using our immature pig IOFH model. Similarly, in our ischemic osteonecrosis mouse model, BMP2 expression and BMP signaling were enhanced in the articular cartilage surrounding the necrotic bone. BMP2 was increased in cartilage explants and primary chondrocytes under hypoxia (1% O(2)) compared with normoxia (21% O(2)). Addition of the hypoxia inducible factor 1 (HIF1) activator DFO significantly increased BMP2 while HIF1 silencing (siHIF1) only partially reduced BMP2, suggesting other mechanisms of BMP2 upregulation being present. Hypoxia is known to induce the production of free oxygen radicals, which are converted to hydrogen peroxide (H(2)O(2)) by superoxide dismutase 2 (SOD2). As an alternative mechanism, we investigated the effect of H(2)O(2)/SOD2 production on BMP2 upregulation. Chondrocytes produced more H(2)O(2) under hypoxia than normoxia. H(2)O(2) addition to the chondrocyte culture also significantly increased BMP2 expression. SOD2 was also dramatically increased in the ischemic pig cartilage at 24h following surgery and in primary chondrocytes/cartilage explants culture under hypoxia. SOD2 protein addition to the chondrocyte culture significantly increased BMP2. Moreover, DFO significantly increased SOD2 while HIF1 silencing only partially reduced SOD2. These results suggest that the acute BMP2 response of chondrocytes to ischemic osteonecrosis is more dominantly through the H(2)O(2) production and only partly through the HIF1 pathway.
Copyright © 2012 Elsevier Inc. All rights reserved.
A Drosophila transgenic RNAi screen targeting the glycan genome, including all N/O/GAG-glycan biosynthesis/modification enzymes and glycan-binding lectins, was conducted to discover novel glycan functions in synaptogenesis. As proof-of-product, we characterized functionally paired heparan sulfate (HS) 6-O-sulfotransferase (hs6st) and sulfatase (sulf1), which bidirectionally control HS proteoglycan (HSPG) sulfation. RNAi knockdown of hs6st and sulf1 causes opposite effects on functional synapse development, with decreased (hs6st) and increased (sulf1) neurotransmission strength confirmed in null mutants. HSPG co-receptors for WNT and BMP intercellular signaling, Dally-like Protein and Syndecan, are differentially misregulated in the synaptomatrix of these mutants. Consistently, hs6st and sulf1 nulls differentially elevate both WNT (Wingless; Wg) and BMP (Glass Bottom Boat; Gbb) ligand abundance in the synaptomatrix. Anterograde Wg signaling via Wg receptor dFrizzled2 C-terminus nuclear import and retrograde Gbb signaling via synaptic MAD phosphorylation and nuclear import are differentially activated in hs6st and sulf1 mutants. Consequently, transcriptional control of presynaptic glutamate release machinery and postsynaptic glutamate receptors is bidirectionally altered in hs6st and sulf1 mutants, explaining the bidirectional change in synaptic functional strength. Genetic correction of the altered WNT/BMP signaling restores normal synaptic development in both mutant conditions, proving that altered trans-synaptic signaling causes functional differentiation defects.
Despite reports of sex steroid receptor and COX2 expression in desmoid-type fibromatosis, responses to single agent therapy with anti-estrogens and non-steroidal anti-inflammatory drugs are unpredictable. Perhaps combination pharmacotherapy might be more effective in desmoid tumors that co-express these targets. Clearly, further understanding of the signaling pathways deregulated in desmoid tumors is essential for the development of targeted molecular therapy. Transforming growth factor-β (TGFβ) and bone morphogenetic proteins (BMP) are important regulators of fibroblast proliferation and matrix deposition, but little is known about the TGFβ superfamily in fibromatosis. A tissue microarray representing 27 desmoid tumors was constructed; 14 samples of healing scar and six samples of normal fibrous tissue were included for comparison. Expression of selected receptors and activated downstream transcription factors of TGFβ family signaling pathways, β-catenin, sex steroid hormone receptors and COX2 were assessed using immunohistochemistry; patterns of co-expression were explored via correlational statistical analyses. In addition to β-catenin, immunoreactivity for phosphorylated SMAD2/3 (indicative of active TGFβ signaling) and COX2 was significantly increased in desmoid tumors compared with healing scar and quiescent fibrous tissue. Low levels of phosphorylated SMAD1/5/8 were detected in only a minority of cases. Transforming growth factor-β receptor type 1 and androgen receptor were expressed in both desmoid tumors and scar, but not in fibrous tissue. Estrogen receptor-β was present in all cases studied. Transforming growth factor-β signaling appears to be activated in desmoid-type fibromatosis and phosphorylated SMAD2/3 and COX2 immunoreactivity might be of diagnostic utility in these tumors. Given the frequency of androgen receptor, estrogen receptor-β and COX2 co-expression in desmoid tumors, further assessment of the efficacy of combination pharmacotherapy using hormonal agonists/antagonists together with COX2 inhibitors should be considered.
© 2012 Japanese Cancer Association.
Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals and for systematically comparing the timing and extent of different signals in different cellular contexts. We used recombinase-mediated cassette exchange (RMCE) to test the effect of successively deleting conserved genomic regions of the ubiquitously active Rosa26 promoter and substituting the deleted regions for regulatory sequences that respond to diverse extracellular signals. We thereby created an allelic series of embryonic stem cells and mice, each containing a signal-responsive sentinel with different fluorescent reporters that respond with sensitivity and specificity to retinoic acids, bone morphogenic proteins, activin A, Wnts or Notch, and that can be adapted to any pathway that acts via DNA elements.
Recent successes in deriving human-induced pluripotent stem cells (hiPSCs) allow for the possibility of studying human neurons derived from patients with neurological diseases. Concomitant inhibition of the BMP and TGF-β1 branches of the TGF-β signaling pathways by the endogenous antagonist, Noggin, and the small molecule SB431542, respectively, induces efficient neuralization of hiPSCs, a method known as dual-SMAD inhibition. The use of small molecule inhibitors instead of their endogenous counterparts has several advantages including lower cost, consistent activity, and the maintenance of xeno-free culture conditions. We tested the efficacy of DMH1, a highly selective small molecule BMP-inhibitor for its potential to replace Noggin in the neuralization of hiPSCs. We compare Noggin and DMH1-induced neuralization of hiPSCs by measuring protein and mRNA levels of pluripotency and neural precursor markers over a period of seven days. The regulation of five of the six markers assessed was indistinguishable in the presence of concentrations of Noggin or DMH1 that have been shown to effectively inhibit BMP signaling in other systems. We observed that by varying the DMH1 or Noggin concentration, we could selectively modulate the number of SOX1 expressing cells, whereas PAX6, another neural precursor marker, remained the same. The level and timing of SOX1 expression have been shown to affect neural induction as well as neural lineage. Our observations, therefore, suggest that BMP-inhibitor concentrations need to be carefully monitored to ensure appropriate expression levels of all transcription factors necessary for the induction of a particular neuronal lineage. We further demonstrate that DMH1-induced neural progenitors can be differentiated into β3-tubulin expressing neurons, a subset of which also express tyrosine hydroxylase. Thus, the combined use of DMH1, a highly specific BMP-pathway inhibitor, and SB431542, a TGF-β1-pathway specific inhibitor, provides us with the tools to independently regulate these two pathways through the exclusive use of small molecule inhibitors.


Living with diabetes may be challenging, but you don't have to go it alone. UnityPoint Health is committed to helping you live well with diabetes by providing coordinated care through education, coaching and support.
Importance of Diabetes Education
Diabetes Education helps people with or at risk for diabetes gain the skills and knowledge needed to change their behavior and successfully manage diabetes and its related conditions. With so much misinformation available about how to manage diabetes, it is important to partner with an expert to help you navigate the disease.
That is why our diabetes educators will team with you, your support caregiver and your provider to optimize your diabetes control while in our care. To meet your needs, Diabetes Education is provided through group classes or individual sessions.
7 Behavior Changes to Improve Quality of Life
People with diabetes or prediabetes can often improve their quality of life by changing their behavior. The American Association of Diabetes Educators points to these seven key self-care behaviors:
- Being active
- Taking medication
- Problem solving
- Healthy coping
- Reducing risks
Your healthcare team will help you learn what to do to live well with Diabetes. Your team members include your doctor, nurse, care coordinator, social worker, dietitian and pharmacist. Your team members may also include nurses and Certified Diabetes Care and Education Specialists (CDCES); these team members have experience educating people with diabetes and have passed an examination to become certified. They work with you as your teacher, coach and counselor.
Care at Home
Home care nurses work with patients to develop a plan for diabetes management that allows for a healthier and more fulfilling life. UnityPoint at Home serves as an extension of your healthcare team in your home. Home care helps patients like you:
Coordinate care with your provider and care team
- Reach your health goals with care centered on you
- Review your medications and help you understand how to take them
- Understand how to manage your diet, medications and exercise
- Avoid hospitalizations and emergency room visits
- More easily access wound nurse experts for diabetic foot and wound issues
- Monitor and manage symptoms
Types of Diabetes
Prediabetes is diagnosed when blood sugar is higher than normal but not high enough to diagnose Diabetes. Type 2 diabetes may be prevented or delayed with lifestyle changes. The prediabetes class focuses on healthy eating and being active.
Fasting blood sugar:
Learn more about prediabetes in our Diabetes Health Library.
- Normal: less than 100
- Pre-diabetes: 100-125
Type 1 Diabetes
Type 1 diabetes is usually diagnosed in childhood but can occur in adults. With Type 1 diabetes, the pancreas does not make insulin -- a hormone needed to turn starches, sugars and other food into energy the body can use. People cannot live without insulin.
Type 1 diabetes is an autoimmune disease. The immune system attacks the pancreas and kills the cells that make insulin.
Type 1 diabetes is treated with healthy eating, physical activity and insulin. A person with Type 1 diabetes must take insulin every day.
Learn more about Type 1 diabetes in our Diabetes Health Library.
Type 2 Diabetes
Type 2 diabetes is diagnosed when:
- Fasting blood sugar is 126 or higher
- Glucose tolerance test is 200 or higher
- A1c is 6.5 percent or higher. (The A1c is a blood test that measures your average blood sugar over about three months.)
If you have Type 2 diabetes, your body doesn't use insulin correctly. This is called insulin resistance. Over time, your pancreas can't make enough insulin to overcome the insulin resistance and blood sugar gets too high.
Type 2 diabetes is life-long. There is no cure, but there are things you can do to control your blood sugar. Keeping blood sugar in a healthy range will help prevent, reduce or delay other health problems caused by diabetes.
Type 2 diabetes is caused by having family members with Type 2 diabetes, being overweight, being physically inactive, being a member of certain ethnic groups (African-American, Latin-American, Native American, Asian, Native Alaskan, Native Pacific Islander) or for no reason at all. Type 2 diabetes is most commonly found in adults, but children may also be diagnosed with Type 2 diabetes.
Type 2 diabetes is treated with healthy eating, physical activity and oftentimes insulin.
Learn more about Type 2 diabetes in our Diabetes Health Library.
Gestational diabetes is a form of Type 2 diabetes, and it may begin between the 24th and 28th week of pregnancy. All women become resistant to the action of insulin late in pregnancy. Women who have gestational diabetes are not able to produce enough insulin to overcome the insulin resistance and blood sugar goes too high. If blood sugar is too high during pregnancy, it can cause several problems:
- Large baby and difficult delivery with risk of injury to mother or baby
- Premature birth and under-developed lungs or liver if baby gets too big
- Low blood sugar in the baby after birth
Increased risk for childhood obesity and Type 2 diabetes as an adult
Gestational diabetes is treated with healthy eating, physical activity and sometimes medicine, including insulin.
Learn more about gestational diabetes in our Diabetes Health Library.
Advanced Treatment Options
Insulin Pump Therapy
An insulin pump continuously delivers fast-acting insulin in the fat tissue beneath the skin. People with Type 1 or Type 2 diabetes may use an insulin pump. The insulin is delivered through a small tube under the skin.
Benefits of pumping insulin:
- Delivers insulin to mimic the human pancreas as closely as possible
- The background insulin delivery rate can be adjusted throughout the day
- Fewer pokes through the skin
- Flexible dosing for differing lifestyles
Drawbacks of pumping insulin:
- Pump is attached to you nearly all the time
- If insulin delivery stops, you may become very ill
- It takes time and patience to learn how to effectively use pump
- Pumping can be expensive
Get help comparing your options in our Diabetes Health Library.
Continuous Glucose Monitors
Continuous glucose monitors (sensors) detect the sugar in the fluid between your body cells (interstitial fluid) instead of in the blood. Sugar is detected continuously and reported to the receiver frequently. The main benefit of using a sensor is that it tells your current reading as well as if sugar is going up or down and how fast. If you know the direction of your sugar, you can take action to prevent a low or severe high.
The sugar reading is sent to a receiver. Some sensors use an insulin pump as the receiver while other sensors come with a separate receiver. You don't have to use an insulin pump to use a sensor, but if you use a sensor, you still must check your blood sugar by finger-stick for any decisions about your insulin dose, if you feel low, and to calibrate the sensor.
Diabetes Information and Resources
There are several online resources for patients managing diabetes and their families. Below are some resources that may be helpful:
Type 1 Diabetes
Type 1 or Type 2 Diabetes
These instructions are for general information. Please consult your doctor or diabetes educator for your personal instructions.


Georgia Chapter, American Academy of Pediatrics
Georgia Chapter, American Academy of Pediatrics The AAP is comprised of over 53,000 general pediatricians and pediatric medical and surgical sub-specialists. There are approximately 1,400 members in the Georgia Chapter. The Chapter is governed by its 25-member board of directors. The mission of the Georgia Chapter is: 1.) To improve the health and welfare of all infants, children, adolescents and young adults in the State of Georgia; and, 2.) To unite qualified pediatricians of the state into a representative organization for the advancement of the practice of pediatrics.


Have you eaten Quorn / Mycoprotein recently and experienced side effects such as nausea and vomiting? You aren't alone. Many hundreds of people experience the same side effects. Read on to find out what Quorn is really made from and read about other people's experiences after eating it.
Your arteries are the rivers within you that continually transport essential nutrients and oxygen from your heart to the rest of your body. A big part of staying healthy and keeping your arteries clean is your diet. After all, as they say, you are...
Jambul, Java Plum, Black Plum, and Indian blackberry are some of the names for the Jamun tree and its fruit. It's well known for its benefit in diabetes. Here is more information about it...
Tomato craving (tomatophagia) may be tied to iron deficiency (anemia) and perhaps deficiencies of other minerals and vitamins. But is it possible to overdose on tomatoes?
Oranges and Orange juice are a powerhouse of Vitamin C (next only to Amla, the Indian Gooseberries) with a plethora of health benefits. Read on to find more...
This article explains how to get bigger and stronger by using the workout that Arnold Schwarzenegger used when he started lifting weights. Read this to learn how to pack on muscle and gain bodyweight.
Information about vitamins. Includes the benefits of vitamins, types of vitamins: A, B1, B2, B3, B5, B6, B12, C, D, E and vitamin K. See the main foods that contain these vitamins
Carrot is a superfood, a super veggie. Want to know more? Here are eight research-based health facts about carrots to prove my point. Read, relax, and eat carrots.
Super grains - 9 super-food grains and pseudograins to include in your diet for health benefits including vitamins and antioxidants to reduce inflammation and strengthen the immune system
A list of some of the best protein substitutes for meat, a short list of how many grams of protein are in some substitutes, a list of what complimentary proteins to combine in order to make a complete protein, and a list of how many grams of protein people need every day according to their age.


Chia seeds’ capacity to reverse inflammation, control cholesterol and decrease hypertension ensure it is really beneficial to take in for coronary heart well being. (19) Also, by reversing oxidative anxiety, a person is not as likely to develop atherosclerosis when they’re often consuming chia seeds.
The examine split these volunteers into three groups: curcumin procedure by itself, diclofenac sodium on your own, and a mix of the two. The outcome from the demo were being eye-opening:
It is crucial to recognize that even in wholesome people today without having fundamental healthcare disorders, there is often the chance linked to any medication. Some great benefits of getting an anti-inflammatory medication have to be well balanced with the possible hazards of using the medication.
The outer layer of peppercorn helps in the breakdown of Unwanted fat cells. Consequently, peppery foods are a good way that can assist you lose excess weight By natural means.
Most NSAIDs inhibit the clotting of blood for only some several hours. Ketorolac (Toradol) is an extremely powerful NSAID and it is used for reasonably critical acute pain that typically needs narcotics.
Inflammation for a bodily purpose will not be always a foul issue. When the human body is wounded or ill, the lymphatic (immune) system springs into action, bringing the immune method’s army of white blood cells to the realm of issue by using amplified blood flow.
I’m perplexed about curcumin and turmeric. I provide the perception that curcumin, not turmeric, continues to be researched and which you could’t Cook dinner with curcumin, but you can find it as being a complement that costs about the same as turmeric supplements. If you’re likely to complement, which would you great site recommend, turmeric or curcumin? And why?
The anti-inflammatory effects of curcumin have also been researched as a doable procedure for Alzheimer’s ailment.
People with a significant allergy to at least one NSAID are likely to knowledge an identical response to another NSAID.
Migraine headache is a variety of headache by which the exact trigger isn't acknowledged; having said that, They might be inherited, and selected...
In India and Pakistan, black peppercorn powder blended with salt, plus the combination is a common merchandise found around the
Dr. Josh Axe is over a mission to supply you and your family members with the highest high-quality nutrition tips and balanced recipes on earth...Enroll to acquire VIP access to his eBooks and beneficial weekly well being strategies for Free of charge!
Last but not least, establishing a daily regimen of Actual physical action can assist avoid systemic inflammation from build up or returning.
A dry socket is a potential complication which can occur any time a blood clot during the gums results in being dislodged after a tooth extraction....


One of the countless blood draws that Calvin has had to endure because of his epilepsy.
If you cannot view the video go to: http://www.youtube.com/watch?v=CHXbw0W5QS4
Please share Calvin's story and help bring us one step closer to a cure for epilepsy.
Give to cure epilepsy: http://www.calvinscure.com
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PROVIDENCE— Lt. Gov. Elizabeth Roberts today issued the following statement on President Bush’s veto of the Stem Cell Research Enhancement Act of 2007, legislation that would have eased the current federal restrictions on stem cell research.
“I am deeply disappointed at President Bush’s decision to veto the Stem Cell Research Enhancement Act, a piece of legislation that had strong bipartisan support in Congress and would have given hope to millions of Americans who suffer from the most debilitating and life-threatening diseases of our time. By expanding access to embryonic stem cell lines and imposing strict ethical guidelines for conducting stem cell research, this critical legislation would have loosened the reins on our country’s most brilliant scientific minds to pursue life-changing medical therapies and cures.
“I believe strongly that the potential human and economic benefits of stem cell research for Americans are too great to be ignored. As a nation, we stand at the threshold of incredible advances in medicine, and as the leader of our country, President Bush is making a grave mistake in turning his back on these scientific advancements and breakthroughs.”
In April, Lt. Gov. Roberts released a report that called on Rhode Island to take immediate action to define what form stem cell research should take in the state. Roberts’ report, entitled “Discovering Rhode Island’s Stem Cell Future: Charting the Course Toward Health and Prosperity” is available electronically on Roberts’ website at www.ltgov.ri.gov.
In the coming months, Roberts plans on working closely with the House Regenerative Medicine and Research Advisory Study Commission, scientists, researchers, doctors, members of the business community, faculty from Rhode Island’s colleges and universities and concerned members of the public to form answers to these essential policy questions, undertake a thoughtful and deliberate discussion of stem cell research and regenerative medicine, and develop a blueprint for action.


5-A. Were the Intermediary's adjustments to the Provider's bed count as used for purposes of the indirect medical education
(IME) calculation proper?;
5-B. In calculating the Provider's bed count as used for purposes of IME calculation, should there have been a reduction
for beds used for observation purposes?;
5-C. For purposes of the Provider's intern and resident count for IME, was the Intermediary correct in disallowing research
rotations for residents participating in an approved medical residency program at the Provider?


Women Centered Care
Around the world-in both industrialized and low- and middle-income countries- too many women who give birth in health facilities face undignified conditions, a lack of services and resources, and poor quality of care. Health care worker performance is often hindered by sub-optimal care environments, including poor infrastructure, limited supplies, heavy workloads and insufficient support.
Did you know?
Nearly one-quarter of all maternal deaths are associated with postpartum hemorrhage (PPH) globally
The Implementation Science Collaborative (ISC) is an unincorporated partnership under development with the support of USAID’s Health Evaluation and Applied Research Development (HEARD) Project and its implementing partners.


GIFT IVF Center, Cochin, India
Received Date: September 06, 2017; Accepted Date: September 11, 2017; Published Date: September 14, 2017
Citation: Mani A (2017) A Case Report of Severe Anemia in a North Indian Surrogate Mother. J Gen Pract (Los Angel) 5:326. doi: 10.4172/2329-9126.1000326
Copyright: © 2017 Mani A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of General Practice
Recently, our unit tackled a case of severe anemia in a surrogate mother during the third trimester of a twin pregnancy. Her hemoglobin was just 5 g/dl, whereas the normal range should ideally be within the range of 12 g/dl to 14 g/dl. Due to timely intervention, we managed to avoid complications. However, it is important to discuss this case, as it is found that in the Assisted Reproductive Technology (ART) centers worldwide, multiple embryo transfers is preferred over single embryo transfers, which often result in higher morbidity and mortality in mothers and infants.
Iron deficiency anemia; Surrogate mothers; Pregnancy third trimester; Maternal death; Twin pregnancy; High risk pregnancy; HELLP Syndrome; Maternal mortality; Haemoglobinopathies; Embryo transfer; Malnutrition; Vitamin B12
Anemia is a medical condition characterized by low hemoglobin (Hb). It is very important to recognize and treat this condition in pregnancy, as both mother and fetus gets affected due to the low availability of oxygen, which is necessary for the metabolism. Pregnant women fall under high risk as there can be loss of blood during miscarriage or delivery, which compromises the health of the mother leading to morbidity and mortality.Types of Anemia in Pregnancy
• Nutritional Anemia: Deficiency of iron, folic acid, vitamin B12 and proteins causes Anemia.
• Hereditary Anemia: Hemoglobinopathies like sickle less anemia, thalassemia and many other genetic conditions.
• Hemolytic Anemia: These are less common and due to increase in breakdown of RBC- ex : HELLP Syndrome
Prevalence in India
As per WHO (World Health Organization) figures, anemia in pregnancy is high in India at 65-75% compared with 51% in developing countries and 14% in developed countries . Reportedly, around 2 billion people amounting to one third of global population are anemic . Indian maternal deaths contribute to 80% of deaths from anemia in South Asia .
Studies conducted in India
Several surveys have been conducted in different parts of India on anemia. National Family Health Survey (NFHS) [4,5], District level household survey (DLHS) , Indian Council of Medical Research (ICMR), micronutrient survey by National Nutrition Monitoring Bureau (NNMB) are some of them. These studies have indicated that anemia is not restricted to poor or underprivileged people and is high even among rich and educated groups . They have found that the most common cause for anemia is low intake of iron and folic acid in the Indian diet. The fiber intake along with high phytates in the diet also reduced the absorption of Iron. The third reason is worm infestation, causing small amount of blood loss over long periods and also infections like malaria [7,8].
There are stages of Anemia where the women can go through compensated anemia, decompensated anemia and the circulatory failure which occurs at Hb levels less than 5.0 g/dl. When HB is very low, anaerobic metabolism occurs due to low oxygen resulting in the increase of Lactic acid. If this is not managed on time then pulmonary edema and death can happen. Cardiac failure can happen in around one third of cases when Hb is less than 5 g/d . Delivery poses real threat to these women, as even a minimal loss of 200 ml of blood can result in circulatory failure. Proper treatment of severe anemia can help to save mothers life and it is important that, blood transfusion and iron injections are readily available, for a good obstetric practice.
Mode of Iron treatment
Oral iron preparations have not shown to help in moderate/severe anemia . Parenteral Iron preparations must be available at community health centres and primary health centres to improve the situation. Blood transfusion is the most important step in improving severe anemia.
A healthy surrogate mother underwent embryo transfer with two day 3 embryros after priming and lutical support. During the screening process, her Hb was noted to be 9 g/dl and she was prescribed Iron tablets as per usual practice. She conceived and twin pregnancy was confirmed in an early pregnancy scan. Routine medications were given along with luteal support. The surrogate mother wanted to return to her village in North India, so she was discharged at 8 weeks of pregnancy, until this time, she was hospitalized due to vomiting.
The surrogate mother had routine antenatal case and all her checkups and scans were normal till sixth month. Low Hb of 8 g/dl was noted after the screening at 24 weeks. Although, she was advised to get admitted, she refused and returned home along with Iron, folic acid, vitamin B complex and protein supplements. She suffered from vomiting, in spite of administering antiemetics and she was reluctant to take iron tablets as she suffered from constipation and gastritis. She was reluctant to come for check-ups and often the coordinator had to call multiple times to request her to come for check-up. At the 30th week, she was noted to have very low Hb of 5.5 g/dl which indicated severe anemia. Surprisingly, even after repeated questioning, she did not admit to any medical symptoms, not even tiredness or dizziness. The growths of both the fetus were seen to be normal on scan.
She was recognized as high risk pregnancy, was admitted and all investigations were done to evaluate the cause of anemia. Peripheral smear showed microcytic hypo chromic anemia, the serum ferritin was 8.49 ng/ml, which is much below the normal levels. Her serum albumin levels were below normal and the stool was negative for occult blood. Deworming was done with albendazole. Parenteral Iron Infusions were started as slow infusion of Iron Sucrose injection (has elemental iron of 20 mg). After 2 days she was noted to have mild jaundice and her Bilirubin was marginally raised to 1.2 mg/dl, indirect Bilirubin 0.67 mg/dl. Her blood tests for Hb electrophoresis were still pending. Her Hb levels were not improving, so blood transfusion was started. Along with that other infusions like I.V. Vitamin B Complex and I.V. Amino acids were also started. Hoping that it is only a case of severe Iron deficiency anemia and no other Haemoglobinopathies are present, she was treated. Cardiotocography (CTG) was done daily to assess the wellbeing of both the fetus. Blood screening with Hb electrophoresis came back as normal. She was transfused with 4 units of blood and her Hb came up to 9.7 gm/dl after 1 week. Her Liver function tests were conducted daily and stayed the same.
When I am writing this article she is ready to go home after her Caesarian section and her Hb is 10.5 g/dl and her LFT is normal. The two healthy babies were handed over to the biological parents.
Analysis of the case
Although she was paid on a monthly basis for good food and other expenses, we suspect that she was not taking care of her diet. The prolonged duration of vomiting, could have added to the malnourishment. The compliance with Iron tablets, vitamin tablets and protein is highly doubtful. The biggest iatrogenic contributor is the twin pregnancy due to transfer of 2 embryos, which could have been avoided. As surrogate mothers are given the choice of staying at hospital or their house, it is difficult to ensure compliance with medicine and diet. In comparison with the other surrogate mothers who opted to return to their own homes during pregnancy term, this was an isolated case.
As mentioned before, the prevalence of Anemia is very high in India and is a major contributing factor for maternal and fetal morbidity and mortality. This should be addressed by the government and steps should be taken to eradicate this condition by fortification of food, by providing free supplement to pubertal girls and pregnant and lactating mothers. Educating rural and urban women about appropriate diet and spacing of pregnancies will definitely make a positive impact. As the hook worm infestation is high in India, Government should take steps to bring about a policy to deworm every pregnant woman like the polio eradication program. This will be efficacious, practically possible, cheap and prevent many fatalities of pregnant women and infants. More studies should be conducted in rural areas to identify the real magnitude of this problem, as it appears to be just a tip of the iceberg.
A proper national regulatory body to control the Assisted Reproduction Technology (ART) like the Human Fertilization and Embryology Authority (HFEA) in UK will ensure that multiple pregnancies are minimized. The current practices of gynecologists transferring multiple embryos (even 5 or 6 embryos) are definitely contributing to the existing problem of anemia. There are plenty of conferences happening in medical field, but they are mostly teaching about new technologies and new medicines. It is high time that we realize that basics are more important in saving lives and we should have more studies and lectures on simple problems like anemia, which is easily preventable.


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Transportation aide jobs in Portland
Earn $17.94 to $23.90 an hour supporting patient care at Oregon’s only academic health center. You may qualify for a $3,000 hiring bonus. As a transportation aide, you will:
- Transport patients, equipment, lab specimens and other items in OHSU care settings.
- Support doctors and nurses in providing high-quality care.
- Depending on the job, qualify for a generous benefits package.
- Make a real difference in the lives of patients and families.
Apply for a hospital transportation job at OHSU
Why join OHSU as a transportation aide?
OHSU is Oregon’s only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals.
- The full-time or part-time schedule that works for you.
- A chance to be on the front lines of health care, bringing compassion and dedication directly to patients and families.
- Opportunities for career advancement.
- A welcoming environment with leaders striving to build an anti-racist, multicultural institution.
- Support and resources for people of all ages, ethnicities, genders, national origins, religions and sexual orientations.
- Wellness programs to support your physical, emotional and financial health.
Many roles come with a complete benefits package that includes:
- Medical, dental and vision coverage at low or no cost to employees
- Access to retirement plans
- Up to 200 hours (equal to 25 full days) a year of paid time off
- 96 hours of sick leave a year (prorated for part-time employees)
- Eight paid holidays a year
- Commuter subsidies
- Tuition reimbursement
- Access to group life insurance, disability insurance and other supplemental benefits
- Discounts just for OHSU members
Living in Oregon
Oregon offers majestic landscapes, a vibrant yet easygoing vibe, and some of the best food, beer and coffee in the world. Learn about the sights, sounds and people in the state we love to call home.


Research Paper Title
Sleep duration and musculoskeletal injury incidence in physically active men and women: A study of US Army Special Operation Forces soldiers.
In physically demanding occupations or athletic populations, sleep has been shown to be an important factor for both performance and recovery. However, evidence is limited on sleep duration and its association with musculoskeletal injury risk in physically active populations. Therefore, the purpose of this analysis was to evaluate the relationship between sleep duration and musculoskeletal injury incidence in a population of physically active men and women.
Data were collected via electronic survey and analysed for 7,576 soldiers from the United States Army Special Operations Command.
This population was mostly men (95%) ≤ 35 years old (70%). The incidence of musculoskeletal injury was 53% over the twelve months before survey administration. After adjusting for other covariates, soldiers who slept ≤ 4 hours were 2.35 (95% CI: 1.89-2.93, p <0.01) times more likely to experience a musculoskeletal injury compared with those who slept eight ≥ 8 hours. When stratified by age (≤ 35 years, > 35 years), older men were found to have significantly higher risk of a musculoskeletal injury than their younger counterparts across all sleep duration groups.
These findings suggest that sleep duration may be inversely related to risk of musculoskeletal injury. It is possible that interventions targeted at sleep may have a positive impact on prevention of musculoskeletal injuries within physically active populations.
Grier, T., Dinkeloo, E., Reynolds, M. & Jones, B.H. (2020) Sleep duration and musculoskeletal injury incidence in physically active men and women: A study of U.S. Army Special Operation Forces soldiers. Sleep Health. 6(3), pp.344-349. doi: 10.1016/j.sleh.2020.01.004. Epub 2020 Feb 13.


Arthritis is, without a doubt, a leading cause of pain and disability across the world and it is surprisingly common. A recent report estimated that approximately 24 million people in America alone suffer from severe immobility due to some form of arthritis. The term ‘arthritis’ refers to joint inflammation and encompasses over 100 joint conditions however, the most common types are osteoarthritis and rheumatoid arthritis. Although these two conditions have some symptomatic similarities, their underlying causes are quite different which is why it is important to gain the correct diagnosis and associated treatment.
What is Osteoarthritis?
This form of arthritis falls into the category of degenerative or mechanical arthritis and the primary cause is damage to the cartilage on the articulating surfaces due to inflammation and wear and tear of weight-bearing joints or from a previous trauma in that area. It is more prevalent in women than men and onset is usually age-related with those over 65 most affected.
What is Rheumatoid Arthritis?
The root cause of this type of arthritis is abnormal inflammation, usually in the feet and hands, due to an autoimmune disorder. This immune response causes the joint surfaces and tissues around the joints to become damaged causing pain, stiffness and swelling. This condition is not related to age and is also more common in women but, when found in men, it is often more severe.
What is Osteoarthritis = Cartilage Loss?
Normally joint cartilage gets constantly remodelled after joint movement but in those with osteoarthritis this function is altered resulting in abnormal joint cartilage. Over time osteoarthritis causes progressive cartilage loss and a thickening on the subchondral plate. Bony spurs can occur along the joints as well as bone cysts which are fluid-filled holes within the bone. Knees, hips, lower back and hands are common areas affected. Pain often occurs during joint usage and sometimes there is a grating or cracking sensation due to friction between bone and cartilage. Inflammation does occur around the joint tissues and also aids the cartilage degradation process but it is less severe than in those with Rheumatoid Arthritis.
What is Rheumatoid Arthritis = Joint Damage?
The symptoms of this condition can develop gradually or suddenly and it is characterized by severe inflammation of synovium – the soft tissue that lines joints. This leads to joint damage, pain, stiffness and loss of physical function.  It is triggered by an excessive immune response in which antibodies normally deployed to fight foreign substances begin to be directed against tissues within the body. This can affect not only the joints but other organs of the body as well and associated fatigue and fever can result. The immune response causes swelling around the joint that begins to erode the bone and marrow and destroy the surrounding structures. Left untreated, the joint loses its shape and eventually becomes completely immobile and low bone density and osteoporosis can result.
Comparing the Symptoms
Though there is an overlap in some symptoms, these signs that can assist with differentiating between osteoarthritis (OA) and rheumatoid arthritis (RA).
- Swelling and inflammation around the joints is usually associated with RA.
- Pain, restricted joint mobility and joint grating is common in advanced OA.
- OA tends to be unilateral (on one side) while RA is usually bilateral (affecting the same joint on both sides of the body).
- Generally, RA affects multiple joints while OA is experienced in only a few sites.
- Morning stiffness can be an indicator as it is much more prolonged in those with RA – sometimes over an hour in duration.
- Joint movement may bring on OA pain while moving the painful joint may relieve RA stiffness.
- RA patients tend to have other symptoms including tiredness, depression, loss of appetite, weight loss, anaemia, dry eyes and occasional low-grade fever. However, it is important note that these may be caused by other simultaneous conditions.
Diagnosis of a specific type of arthritis is not a simple task and if the above symptoms are experienced it is important to get a thorough assessment from a medical professional. Pinpointing and treating arthritis early are critical to minimizing the impact of the disease in order to prolong ease of movement and decrease the need for surgery. Unfortunately, arthritis is currently considered incurable but these conditions can be controlled through a treatment plan that focuses on relieving pain, reducing inflammation and slowing joint damage for improved quality of life.
RheumaLin is your natural anti-inflammatory solution to combat joint pain and it is gentle on the stomach, making it ideal for the treatment of many types of arthritis. Find out more
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- Kori A. Dewing, DNP, FNP, ARNP; Stephen M. Setter, PharmD, DVM, CDE,CGP, FASCP; Barbara A. Slusher, MSW, PA-C. October 31, 2012. Osteoarthritis and Rheumatoid ¬Arthritis 2012: Pathophysiology, Diagnosis, and Treatment
- Centre for Disease Control and Prevention. Arthritis Basics http://www.cdc.gov/arthritis/basics.htm Accessed 24 April 2014.
- South African Rheumatism and Arthritis Association. “Rheumatoid Arthritis”. http://www.saraa.co.za/C_TeauOverview.asp accessed 22 April 2014


On May 16, 2016, the Equal Employment Opportunity Commission ("EEOC") finalized highly anticipated regulations that purport to define the extent to
The rising cost of health care is a serious concern for employers who provide health benefits to their employees. In 1960, health care spending
The Affordable Care Act provides employees who are not offered health coverage by their employers with the option of purchasing health coverage
The recently enacted Patient Protection and Affordable Care Act ("PPACA") raises a question about the treatment of stand-alone retiree health plans under some provisions of the Employee Retirement Income Security Act of 1974, as amended ("ERISA"), the Public Health Services Act, as amended (the "PHSA"), and the Internal Revenue Code of 1986, as amended (the "Code").
The Patient Protection and Affordable Care Act, as amended ("PPACA"), contains a provision titled "Preservation of Right to Maintain Existing Coverage."
The Patient Protection and Affordable Care Act, as amended ("PPACA"), requires group health plans that offer health coverage to employees' or subscribers' children to make such coverage available until the child's 26th birthday.
The Patient Protection and Affordable Care Act creates the Early Retiree Reinsurance Program (the "Program").
In 2008, Congress passed the Paul Wellstone and Pete Domenici Mental Health Parity and Addiction Equity Act (the "Act").
As reported in an earlier Jones Day Commentary entitled "Open Enrollment AlertNo Reward Goes Unpunished," the Departments of Treasury, Labor, and Health and Human Services jointly issued interim final rules to implement certain provisions of the Genetic Information Nondiscrimination Act ("GINA"), including the prohibition on the collection of genetic information by group health plans and group health insurance issuers.
The Genetic Information Nondiscrimination Act of 2008 became law on May 21, 2008.


Phytochemical investigation of Eryngium creticum L. has resulted in isolation of five compounds, including four compounds that are reported from the plant for the first time. Compound 1 was identified as (E)-rosmarinic acid, meanwhile, compound 2 was isolated as an (E/Z)-rosmarinic acid mixture. Interestingly, the E/Z-isomeric mixture was about 4 times as active as the single E-isomer toward the severe acute respiratory syndrome coronavirus 2 3-chymotrypsin-like protease (3CLpro), IC50= 6.062 and 25.75 μM, respectively. Utilizing combined molecular docking and molecular dynamics (MD) techniques, the binding affinities and features of the isolated compounds were evaluated against 3CLpro. Compound 2Z demonstrated a higher binding affinity for 3CLprothan 2E, with docking scores of -8.9 and -8.5 kcal/mol and MM-GBSA/150 ns MD binding energies of -26.5 and -22.1 kcal/mol, respectively. This justifies the superior activity of the E/Z-isomeric mixture versus the single E-isomer. Structural and energetic analyses revealed the stability of 2Z and 2E compared to the reference HIV-1 protease inhibitor, lopinavir. Besides, DFT calculations demonstrated the more energetic stability of 2E compared to 2Z, which justifies the difficulty in isolating the Z-isomer in a pure form, where it readily isomerizes to the E-isomer.
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)


6 Best Ways To Grow Back Gums
Use of oil is best to remove toxins from the mouth. 1 - Put a tablespoon of of essential oil in the mouth. You may use coconut oil, sunflower oil, sesame oil or palm oil. Sesame oil includes many anti-oxidants, and this oil is known to make the teeth and gums stronger. Sesame oil is preferred by the Indian human population. Children from five to fifteen years can only use One teaspoon of oil. Try blending coconut oil along with other essential oils such as palm oil, sesame oil or sun flower oil, as well as rinse your mouth with oil.
You may apply the paste using a soft-bristled toothbrush. Make a paste using turmeric powder and drinking water. Three - Make a spice-paste. If the tooth brush has hard bristles use your fingers to rub the gum line. Leave the paste in the gums for a few min's then rinse your mouth.
Hormonal imbalance in pregnancy can also lead to some extent of gingivitis. Swollen gums detach from your teeth. The supporting tooth bones are also involved in the process. The result's a gum pocket which often forms quickly due to the harmful bacteria and due to insufficient brushing. The tartar might also lead to advanced form of swollen gums or gum swelling. Your tooth bone tissues might be damaged by gum soreness. It may also reduce in size, and also the tooth appears a bit longer. After the postpartum period, the woman usually returns in just Fourteen to Twenty one days.
When gum disease isn't cured, swollen can damage the teeth and gums badly. As a result of tooth bone damage, your tooth starts to damage and finally start loss of tooth. If you loved this post and you would like to obtain additional details concerning regrow gums naturally at home kindly check out the web-page. Inspite of bone tissue loss, the gums continue to be at their normal height. The plaque buildup then changes in to hardened tartar.
The dental office will help you find out the risk factors involved. 1 - To identify the major reason behind receding gums . There are many factors that can cause recurring gums. Brush forwards and towards and don't apply pressure on your tooth brush. To stop recurring gums, it is important to massage your gums well and brush the teeth so that the gums grow to the chew limit. Use a soft bristles tooth brush. Hold your tooth brush at 45° angle. Then make vertical lines by pulling the gums toward the teeth as it was using your toothbrush. Ensure to brush the teeth daily. The common causes are: smoking cigarettes, aggressive brushing and family genes problem.
2 - Brush your teeth twice daily. Buy a new tooth brush every 3 or 4 months. Should the tongue afterward remove bacteria.
As a result of gum bleeding the teeth cannot be cleaned thoroughly. The gingivitis is often curable by complete care of your teeth without long-term damage. Can gingival recession be cured? There are many things an individual can do at home which can help to prevent the growth of gum recession and help to cure it asap. The pink looking gums will become a deep red because of inflamed gums and bleed very easily when brushing your teeth or when use dental floss.
Make a C shape when you rub the floss in between your teeth as well as the edge of the gums. Be aware and don't pull the filament too hard within the gums. How frequently you go to the dentist depends upon the health of the teeth and gums. Talk to your dental office which tool is useful for you.
4 - Visit your dental office regularly. Flossing is helpful to clear out food particles from teeth. You can use a tooth pick and dental floss. Adults will need to visit the dentist once a year. This type of treatment methods are very expensive. The dental professional can perform surgical treatments to promote the growth of gum line. The dental physician needs to focus on the safety measures on the dental issues.
If you've gingivitis, you need to go to your dentist for a better treatment solution. When the dental physician shows that you'd need special treatment seek advice from a dental professional. Take 45 cm of floss and cover the ends around the middle-fingers.
With little medical proof that these ingredients work. Simultaneously, a person can also use some home-remedies to cure gum recession. Teeth bone tissues are affected by gum disease. If you look and feel changes in the gums, you have to go to your dental office immediately. Use them very carefully and do not see them alternatively for flossing and brushing your teeth and regular appointments with the dentist.
- Method 1 Use the paste on the gum line When the gums begin to recede, you may get inflammed gums.
2 - Use oil to rinse the mouth. You can best try this treatment in the morning before eating. The oil turns milky white colour. Rinse the oil between the teeth for just 10 or 15 mins. If you cannot keep the oil in the mouth for ten to fifteen minutes daily, start with Five minutes and keep oil in the mouth longer and longer.
Gingivitis (an early stage of gum disease) is due to instances of dental plaque. This all natural treatment isn't suggested by the dental health care professionals but used by most people for several years to cure receding gums.
Method 4: Gum recession treatment options by practicing good oral care If you treat your gums with essential oil every day, you will suffer less from accumulated plaque within Ten days.


The Hamad Medical Corporation (HMC) and Qtel yesterday launched the Fahad bin Jassim Kidney Center. The opening of the center comes as a fitting tribute to kick off a week-long World Kidney Day activities.
“The Kidney centre aims to secure world class healthcare services as in all the HMC hospitals. The Fahad Bin Jassim Kidney Center [...]
As part of its ongoing rebranding process, the Managing Director of Hamad Medical Corporation (HMC), Dr Hanan Al Kuwari, formally handed over the individual logos to the Executive Directors of the hospitals under its umbrella. Celebrating the successful rebranding of HMC earlier this month, each hospital is also seeing a facelift to reflect the changes [...]
The re-accreditation, which has happened for the second time, will raise HMC’s profile internationally and help it in further improving its services and attracting highly qualified medical professionals from across the globe, HMC’s Managing Director Dr Haman Al Kuwari has said.
“The re-accreditation is a recognition of the high quality of services being provided by the [...]


CAPH represents California's public hospital systems, which are the core of the state's health care safety net, delivering high quality care to all in need and working to improve the health of their patients and communities.
Though just 6% of all California hospitals statewide, public hospitals:
Since 1999, the California Health Care Safety Net Institute (SNI) has helped public hospital systems develop and spread innovative programs to help improve the quality of patient care and care coordination, enhance efficiencies, and eliminate health care disparities.
CAPH’s Annual Conference, Leading the Way: A New Chapter In Healthcare, will be held this year on December 4-6, 2013 at The Meritage Resort and Spa in Napa, CA.
We will be posting more details soon regarding registration, speakers and the conference agenda.


For more information email email@example.com
Pulitzer Prize-winning investigative journalist and The 1619 Project developer Nikole Hannah-Jones leads the free, CME-bearing moderated discussion, presented by the GW SMHS Two in One Model — in partnership with the GW School of Medicine and Health Sciences Office of Diversity and Inclusion, and Meharry Medical College Division of Public Health Practice.
*Earn 1.0 AMA PRA Category 1 Credit™ for this event.
The virtual event is part of the 2023 GW SMHS Annual MLK Lecture Series “Advancing the Dream: Why We Can’t Wait” series.
For more information and to register, click here to visit the Two in One Model website.


Unhappy with your care or treatment?
We try our best to make sure that patients receive the best possible care. But like any organisation, things can go wrong and we may not be able to reach all of our standards all of the time. Visit the Thatcham Medical Practice Complaints Information page to know more about our procedure.
For further assistance, please call us on 01635 867171 and request to speak with the Practice Manager – Mrs. Linda Lawson.


Most of us worry about visitng the dentist. A moderate amount of anxiety is entirely normal. However, some patients are so afraid of the dentist that it prevents them from accessing the professional dental care that they need.
The whole team at Cavendish House work hard to ensure that every patient is treated in a calm, friendly and relaxing environment.
Our practice has recieved a national award for our care of nervous patients.
For some patients, however caring and friendly the staff are, their anxiety is just too severe for comfortable dental treatment. For these patients we are able to offer IV sedation.
If you are nervous of the dentist - rest assured; we understand your fears and we are here to help.


Lipoma or Cyst?
I have a growth now for over 10 years. When I went to the doctor he told me it was a cyst and that I should not worry about it unless it hurts. . I have 2 from trauma to my ribs from my brother jabbing/prodding me unexpectedly; repeatedly when I was 15. Each started where the lowest rib begin and has spread laterally but adjacent to the lowest ribs on each side so they are large and cause discomfort. I'm concerned with bleeding as I do not accept blood should I be worried about death?
Removal of Cysts and Lipomas
Lipoma or Cyst removal do not require blood
Lipoma or Cyst
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Was well worth the surgery to remove this lipoma which was painful while sleeping on side...


Thread Lift Treatment
How does a Thread Lift work?
Who is suitable for this procedure?
Which areas can be treated with the Thread Lift?
What does the procedure involve?
When can I see results and how long will it last?
Thread Lifts Cost
Vertical Lift (assorted lifting threads) $1800
Vertical Lift & Jawline (assorted lifting threads) $2400
Mandatory safety information:
MINT PDO products are subject to regulation by the U.S. Food and Drug Administration and state and local regulatory agencies [FDA Clearance (2013 - K130191 & 2020 - K192423)]. The information on this site does not, and cannot, provide medical advice and is for general informational purposes only. If you are a patient it is important to discuss health information with your doctor. Individual results may vary.
Hans Biomed’s provision of products, training, or other services to a medical provider, or the listing of a medical provider as using Hans Biomed products or services, including training, does not constitute Hans Biomed’s endorsement, representation of assurance regarding the medical provider’s qualifications, skills or experience, or affiliation. Medical providers are independent of Hans Biomed and subject to their jurisdiction’s licensing requirements. Hans Biomed assumes no liability for services provided by any medical provider. Patients are advised to independently investigate the qualifications of any medical provider.
Hans Biomed provision of products, training or other services to medical providers is not intended, in any way, as the practice of medicine. Hans Biomed product information in any website, product brochure, or in response to any patient inquiry is intended for informational purposes only and makes no guarantee regarding any medical procedure. Decisions whether to use Hans Biomed’s products or their appropriateness for use should be done in consultation with one’s medical provider.


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Proposed legislation aimed at comorbidity among Medicare beneficiaries
Proposed legislation aimed at comorbidity among
April 4, 2016
by Robert Gatty
A "policy options document" developed by the U.S. Senate Finance
Committee's Chronic Care Working Group could form the basis for new
legislation with a significant impact on the long-term care industry.
Issued last December following a series of hearings and stakeholder
meetings, the document suggests a series of options for the committee to
consider with the goal of improving how Medicare treats beneficiaries with
multiple, complex chronic illnesses. The Working Group says any policy
under consideration should meet these key objectives:
Increase care coordination among individual providers across care
settings who are treating individuals living with chronic diseases;
Streamline Medicares current payment systems to incentivize the
appropriate level of care; and
Facilitate delivery of high-quality care, improve care
transitions, produce stronger patient outcomes, increase program
efficiency and contribute to an overall effort to reduce the growth in
Should the committee decide to move forward with its recommendations and
develop a final document, revised after submitted comments, that action is
expected to wait until the new Congress convenes in January 2017 when
lawmakers can return their focus to making improvements many consider
necessary while also reducing overall healthcare expenditures.
Some of the policy options in the document include:
Expanding the Independence at Home Model of Care (IAH)
demonstration into a permanent, nationwide program.
Expanding access to home hemodialysis therapy by including
free-standing renal dialysis facilities in its qualified originating site
Requiring Medicare Advantage (MA) plans to offer the hospice
benefit provided under traditional Medicare.
Allowing end stage renal disease beneficiaries to choose a MA
plan no matter when their condition began.
Providing continued access to MA special needs plans (SNP) for
vulnerable populations through a long-term extension or permanent
authorization of SNPs as established under the Medicare Prescription Drug,
Improvement, and Modernization Act of 2003.
Improving care management services for individuals with multiple
chronic conditions by establishing a new high-severity chronic care
management code under the physician fee schedule.
Developing policies to improve integration of care for
individuals with a chronic disease combined with a behavioral health
Providing MA plans the flexibility to establish a benefit
structure that varies based on chronic conditions of individual enrollees.
Expanding supplemental benefits for chronically ill MA enrollees.
Using telehealth to increase convenience for MA enrollees and for
individuals who have suffered a stroke.
Providing Accountable Care Organizations (ACO) the ability to
expand use of telehealth.
Clarifying that ACOs participating in the Medicare Shared Savings
Program (MSSP) may furnish a social or transportation service for which
payment is not made under fee-for-service Medicare.
Ensuring accurate payment for chronically ill individuals.
Providing flexibility for beneficiaries to be part of an ACO.
Developing quality measures for chronic conditions.
Encouraging beneficiary use of chronic care management services.
Establishing a one-time visit code post initial diagnosis of
Alzheimers disease, dementia or other serious or life-threatening
Eliminating barriers to care coordination under ACOs.
Expanding access to prediabetes education.
Expanding access to digital coaching to help beneficiaries learn
more about their health conditions and in the self-management of their own
Icreasing transparency at the Center for Medicare & Medicaid
Conducting a study of medication synchronization.
Conducting a study on obesity drugs.


Launching a Telepsychiatry Program
July 14, 2020 10:28 am
Licensed in 10 states, Dr. Jenys Allende offers insights into the emerging model of telepsychiatry and what she learned over the past 10 years.
Telehealth Etiquette Video Series
September 16, 2020 3:38 pm
A series of 5 short videos from the University of Arkansas on Telehealth skills and etiquette that may be useful for training.
AMMC Telehealth Competencies
November 12, 2020 2:40 pm
This is a nice piece outlining competencies needing to be taught at various level of medical training relative to telehealth and can be adapted for other purposes.
COVID Smartphrases 3.20
July 14, 2020 10:36 am
An FAQ sheet with answers to COVID-19 smart phrases from Kaiser Permanente.
July 14, 2020 10:27 am
This PDF version of the online Telehealth Readiness Assessment (TRA) tool from the Maryland Health Care Commission is designed to assist small physician practices.
Healthcare IT Guide to Telehealth Vendors
July 14, 2020 10:24 am
Health IT News offers this listing of telemedicine companies that can help hospitals and other providers organizations deliver quality virtual care.
July 14, 2020 10:26 am
Telehealth Technology offers these concise guides for providers with introductions to the equipment and platforms used for telehealth.
Webinars and Podcasts
HIMMS Deploying Telehealth During COVID-19
July 14, 2020 2:44 pm
This 60-minute HIMMS webcast explores how Northwell Health is leveraging multiple technology platforms in new ways during the COVID-19 health crisis.
Telehealth I Deep Dive
July 14, 2020 10:30 am
Part 1 of a 2 part series covers a baseline of telehealth activity throughout the country. Guest speakers include Dr. Ragan DuBose-Morris and Tina Benton.
Telehealth II Deep Dive
July 14, 2020 10:31 am
Part 2 of a 2 part series covers a baseline of telehealth activity throughout the country. Guest speakers include Dr. Ragan DuBose-Morris and Tina Benton.
Front Office Guru – Telehealth Scripts
July 14, 2020 2:11 pm
Still open – want to transition patients to telehealth Use the following 4 parts to the conversation when someone calls to drop out of care during the outbreak:


June 27 is National HIV Testing Day and Interior Health is reminding people that, since last December, an HIV test may be included when patients visit emergency departments and require diagnostic blood work.
Provincial testing guidelines encourage primary care providers to know the HIV status of all patients, not only those deemed at risk. The guidelines also advise that when people are sick, an HIV test should be included as part of blood work to determine a diagnosis, regardless of an individual’s HIV risk factors.
During the past five years, Interior Health has implemented STOP HIV/AIDS, a provincial program to expand access to earlier HIV testing and provide support for individuals to start and sustain HIV medication. When people are consistently taking HIV medications, their viral load drops to an undetectable level, protecting their health by preventing progression to AIDS and AIDS-related premature deaths and stopping transmission of the virus to someone else.
“Routine HIV testing in the emergency department is one of the latest tools being used in Interior Health to end the HIV epidemic,” said says Dr. Michael Murphy, medical coordinator for the STOP HIV/AIDS program in Interior Health.
“Routine testing at a point-of-contact in the health-care system is targeted to detect those 15 per cent of HIV-positive individuals who are unaware of their HIV status. I have personally treated patients who were unaware they were HIV-positive and were diagnosed through testing in the emergency department.”
Dr. Jeff Hussey, an emergency department physician, said he sees patients needing bloodwork who have deteriorated health.
“That’s exactly the criteria to indicate that patients should have an HIV test ordered,” Hussey said.
“We have the perfect opportunity to help detect the 15 per cent of patients that are currently unaware of their HIV-positive status.”
As with other routine blood work, patients who do not wish to have the test during their emergency visit may decline.
The made-in-B.C. STOP HIV/AIDS initiative includes outreach to marginalized groups, expanding access to early testing to diagnose those living with HIV in order to improve health outcomes and reduce transmission and immediate and universal access to free antiretroviral therapy for all who are diagnosed HIV-positive.
For more information about HIV testing, go online to interiorhealth.ca.


2020 Virtual Annual Conference
Thank you for registering! Below are the details for this year's conference, along with your session access links.
All sessions will be taking place in zoom, the links are below.
Zoom Resource Guide
Recording, copying, and/or reproducing a presentation from the MMA Annual Conference without consent is a violation of common law copyright. Questions and requests may be sent to the MMA (firstname.lastname@example.org).
Use the hashtag #mnmed20 to share your thoughts and photos during the conference and after on Twitter, Instagram, etc.
Thursday, September 24, 2020
Virtual inaguration held for MMA's incoming President, Marilyn Peitso, MD
Friday, September 25, 2020
MMA Business Meeting 10am
MMA CEO Janet Silversmith, Board Chair Randy Rice, MD, and the entire MMA Board of Trustees review the work of the MMA in this most extraordinary of years and how physicians across Minnesota have risen to the occasion. Link will be available Friday at 10am.
General Session – COVID-19: Where Are We Now? 12-1pm
Cracks in the Health Care System Exposed by COVID-19 1:30-2:30pm
Concurrent Breakout Sessions (session access linked below)
- How well can current payment models sustain health care access through COVID-19 and other public health emergencies/crises?
- What are the limits of telehealth and its broader adoption?
- Are investments in public health/emergency preparedness adequate to meet COVID-19 and other public health emergencies/crises?
Concurrent Breakout Sessions (session access linked below) 3-4pm
- The Impact of COVID-19 on Medical Education
- COVID-19 and Health Equity
- The Journey to Treat COVID-19
Poster Symposium 4-5:30pm
Saturday, September 26, 2020
General Session: Addressing the Challenges of Viewing Medicine Through a Race-Based Lens 9-10am
Closing Session: Mobilizing Physicians to Create Change 10:15-11:30am
It’s a Wrap! 11:30-noon


2 Clarke Drive
Cranbury, NJ 08512
© 2022 MJH Life Sciences™ and OncLive - Clinical Oncology News, Cancer Expert Insights. All rights reserved.
PD-L1-high status, determined via 3 separate immunohistochemistry assays, and blood tumor mutational burden strongly favored atezolizumab over platinum-based chemotherapy and supports the PD-L1 inhibitor as a first-line treatment option in patients with advanced non–small cell lung cancer.
Roy Herbst, MD, PhD
PD-L1—high status, determined via 3 separate immunohistochemistry (IHC) assays, and blood tumor mutational burden (bTMB) strongly favored atezolizumab (Tecentriq) over platinum-based chemotherapy and supports the PD-L1 inhibitor as a first-line treatment option in patients with advanced non–small cell lung cancer (NSCLC), according to an analysis of the phase III IMpower110 study presented at the 2019 ESMO Immuno-Oncology Congress.1
In patients with the highest PD-L1 expression level, defined as tumor cell (TC)3 or immune cell (IC)3 by Ventana SP142 IHC staining, the median overall survival (OS) was 20.2 months with atezolizumab versus 13.1 months with chemotherapy (HR, 0.59; 95% CI, 0.40-0.89).
“At the interim OS analysis, atezolizumab showed statistically significant and clinically meaningful OS improvements with atezolizumab versus platinum-based chemotherapy in the PD-L1 high by the SP142 antibody population,” said lead study investigator Roy S. Herbst MD, PhD, chief of Medical Oncology, professor of Medicine, Yale Cancer Center, Smilow Cancer Hospital.
OS was similar in patients with high PD-L1 status when PD-L1 was evaluated by Dako 22C3 staining (≥50% tumor proportion score [TPS]) at 20.2 months versus 11.0 months (HR, 0.60; 95% CI, 0.41-0.86) with atezolizumab versus chemotherapy, respectively, and also by SP263 staining (TC ≥50%), where the median OS was 19.5 months versus 16.1 months (HR 0.71; 95% CI, 0.50-1.00), respectively.
The analyses evaluated the efficacy of atezolizumab according to PD-L1 expression status and bTMB. Investigators used data from the phase III IMpower110 study, which met the primary endpoint of OS with atezolizumab in patients with advanced NSCLC who had ≥50% PD-L1 expression on TC3 or ≥10% expression on IC3 (HR, 0.59; 95% CI, 0.40-0.89; P  = .0106).2
The IMpower110 study enrolled 572 chemotherapy-naïve patients with stage IV NSCLC and measurable disease according to RECIST v1.1 criteria and an ECOG performance status of 0 to 1. To be eligible for enrollment, patients had wild-type disease that was EGFR/ALK-negative and PD-L1 expression status ≥1% on TC or IC per the Ventana SP142 assay. Patients were randomized 1:1 to be treated with atezolizumab at 1200 mg intravenously every 3 weeks or platinum-based chemotherapy in 4 to 6 21-day cycles.
The primary endpoint was hierarchically tested OS in wild-type patients, and an additional analysis included OS and progression-free survival in the SP263 PD-L1 positive (cutoffs ≥1% and ≥50% TC) and 22C3 PD-L1 positive (cutoffs ≥1% and ≥50 TPS) patients and in those with bTMB at cutoffs of ≥10, ≥16, and ≥20. A TMB score of 16 was equivalent to approximately 14.5 mutations per megabase.
The biomarker-evaluable population (BEP) in patients with TC1/2/3 or IC1/2/3 comprised 554 patients who were PD-L1 positive according to SP142, 534 patients who were PD-L1 positive by 22C3, 546 who were PD-L1 positive by SP263, and 389 patients with bTMB. The prevalence of PD-L1 expression according to SP263 was 77% (TC ≥1%) and 54% (TC ≥50%); by 22C3 was 78% (TPS ≥1%) and 49% (TPS ≥50%); and by SP142 was 100% (TC1/2/3 or IC1/2/3), 59% (TC2/3 or IC2/3), and 37% (TC3 or IC3).
In the cohort of patients having PD-L1 positivity, represented by TC1/2/3 or IC1/2/3 by SP142, the median OS was 17.5 months with atezolizumab versus 14.1 months with chemotherapy (HR, 0.83; 95% CI, 0.65-1.07). Similar results favoring atezolizumab were seen according to 22C3 staining (TPS ≥1%; HR, 0.73; 95% CI, 0.55-0.97) and SP263 staining (TC ≥1%; HR, 0.77; 95% CI, 0.58-1.02).
“PD-L1 immunohistochemistry and bTMB identified distinct populations of patients in the IMpower110 study,” said Herbst. “OS and PFS were consistently in favor of atezolizumab in PD-L1—high subgroups and this benefit was observed across bTMB subgroups.”
In patients with the lowest PD-L1 expression status, represented by TC1/2 or IC1/2 (SP142), TPS 1% to 49% (22C3), and TC 1% to 49% (SP263), OS began to favor chemotherapy over atezolizumab: HR, 1.04 (95% CI, 0.76-1.44); HR, 1.00 (95% CI, 0.63-1.58), and HR, 0.94 (95% CI, 0.58-1.53), respectively.
PFS also favored atezolizumab in a stepwise fashion according to PD-L1 expression. By SP142 staining patients with TC/IC3 had median PFS of 8.1 months with atezolizumab versus 5.0 months with chemotherapy (HR, 0.59; 95% CI, 0.43-0.82). In patients with PD-L1 status TC1/2/3 or /IC 1/2/3, the median PFS was 5.7 months and 5.5 months, respectively (HR, 0.77; 95% CI, 0.63-0.93). For TC1/2 and IC1/2, the median PFS was 5.5 months versus 5.6 months (HR, 0.90; 95% CI, 0.71-1.15) with atezolizumab versus chemotherapy, respectively.
bTMB was also supported as a prospective biomarker of atezolizumab efficacy. The median OS in patients with bTMB ≥10 receiving atezolizumab versus chemotherapy was 11.2 months versus 10.3 months (HR, 0.87; 95% CI, 0.58-1.30). Median OS with the respective treatments was 13.9 months versus 8.5 months (HR, 0.75; 95% CI, 0.41-1.35) at bTMB ≥16, and 17.2 months versus 10.5 months (HR, 0.77; 95% CI, 0.36-1.64) at bTMB ≥20.
Median PFS with atezolizumab versus chemotherapy, respectively, across the bTMB cutoff points was 5.5 months versus 4.3 months (HR, 0.74; 95% CI, 0.53-1.05), 6.8 months versus 4.4 months (HR, 0.55; 95% CI, 0.33-0.92), and 6.8 months versus 5.2 months (HR, 0.56; 95% CI, 0.30-1.06).
“These findings support atezolizumab as a first-line treatment option in patients with PD-L1—high NSCLC,” Herbst remarked, adding that bTMB appears to be a potential biomarker for checkpoint inhibitor monotherapy.


Magnetic Technology Creates Detailed Images of All Body Parts
Magnetic resonance imaging revolutionized the field of diagnostic medicine when it was introduced in the 1970s. Scientifically complex, the technique uses a magnetic field and radio waves to create images of everything from the brain and breasts to the pelvis and prostate.
Most MRI machines are large and tube-shaped and contain powerful magnets. When a patient lies inside, a magnetic field temporarily realigns hydrogen atoms in the body. Radio waves cause these atoms to produce faint signals, which are used to create the detailed images.
Main Street Radiology's MRI division consists of four sections. The Neuroradiology section specializes in diseases of the brain, spine, head, and neck. Musculoskeletal Radiology focuses on the joints, bones, and muscles of the arms and legs. Our Breast Imaging section uses advanced technology to evaluate breast health and look for possible tumors. Finally, the Body Imaging sections perform exams of the chest, abdomen, pelvis and cardiovascular system.
We have a full range of state-of-the-art MRI technology, including some that's rarely found outside of major research institutions. Often, we use a combination of MRI techniques to provide our patients with the best results.


Arabic Name : Dar Seenee, Qirfa
Bengali Name : Dalchini, Daruchini
Chinese Name : Jou kuei, Gui zhi
English Name : Cinnamon Bark
French Name : Cannelle
German Name : Ceylon-Zimt, Kaneelbaum
Gujarati Name : Dalchini
Hindi Name : Dalchini, Daruchini, Darchini
Kannada Name : Dalchini
Latin name : Cinnamomum zeylanicum Blume.
Marathi Name : Dalchini
Persian Name : Darchini
Punjabi Name : Dalchini, Darchini
Sanskrit Name : Tvak, Bhringa
Urdu Name : Darchini
Description : Darchini is useful for stomach and digestive complaints and boosts absorption by means of intensifying your body’s capability to thoroughly collapse and soak up nutrients from food. Further alleged advantages of Darchini involve: combating fungal infectivity, alleviating sickness, remedying diarrhea, intensifying peripheral circulation, heating up the body, lessening blockage and curing uterine hemorrhage. It may possibly help in lowering cholesterol and triglyceride levels and supporting hearth strength. These performances are founded mainly on subjective and not scientific proofs.
- It helps calm the stomach.
- It helps to clear up urinary tract infections.
- It also kills many fungi and viruses that cause diseases.
- Cinnamon (Darchini) is used for stimulating gastric and digestive juices and carminative.
- In diabetic patients, it helps metabolize sugar in a better way using less insulin.
- Ancient Chinese references mention about use of Cinnamon as early as 2700 BC as a medicine for relieving nausea, fever, diarrhea and menstrual problems.
- It is an antiseptic that helps kill bacteria which cause tooth decay and gum disease, and that is why most of the tooth pastes are cinnamon flavored.
Recommended Dosage : Bark :- 375 mg to 2 g powder; Oil : 1 to 3 drops. For external application only.
Contraindication : If pregnant or breast-feeding do not consume more cinnamon than is normally present in food. Men with prostate problems, diabetics and those taking blood thinners should consult a health care provider before using this herb. This product is not recommended if you have a tendency toward excessive menstrual bleeding. Taking this herb and antibiotics together may make the antibiotic not work for you. Increased heart rate (pulse), feeling dizzy, shortness of breath and redness of the face may occur if you take too much Cinnamon. Undiluted essential oil in their purest state is extremely potent, and should be blended with a carrier oil or other medium prior to use directly on the skin, as the essential oil may cause irritation.


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Scientists have identified 7 healthy linked to lower rates of dementia in those with genetic risk.
According to a study recently published in Neurology, the medical journal of the American Academy of Neurology, seven healthy habits and lifestyle factors may help reduce the risk of dementia in people with the greatest genetic risk.
The seven cardiovascular and brain health factors are known as the American Heart Association’s Life’s Simple 7: being active, eating healthier, losing weight, not smoking, keeping a healthy blood pressure, regulating cholesterol, and lowering blood sugar.
“These healthy habits in the Life’s Simple 7 have been linked to a lower risk of dementia overall, but it is uncertain whether the same applies to people with a high genetic risk,” said study author Adrienne Tin, Ph.D., of the University of Mississippi Medical Center in Jackson. “The good news is that even for people who are at the highest genetic risk, living by this same healthier lifestyle are likely to have a lower risk of dementia.”
In the research, 2,738 people with African heritage and 8,823 individuals with European ancestry were tracked over the course of 30 years. At the start of the trial, participants’ average age was 54.
The levels of each of the seven health factors were reported by study participants. The range of total scores was 0 to 14, with 0 being the most unhealthy score and 14 denoting the most healthy score. People of European heritage scored on average 8.3, whereas people of African descent scored on average 6.6.
Researchers calculated genetic risk scores at the start of the study using genome-wide statistics of Alzheimer’s disease, which have been used to study the genetic risk for dementia.
Participants with European ancestry were divided into five groups and those with African ancestry were divided into three groups based on genetic risk scores. The group with the highest genetic risk included people who had at least one copy of the APOE gene variant associated with Alzheimer’s disease, APOE e4. Of those with European ancestry, 27.9% had the APOE e4 variant, while of those who had African ancestry, 40.4% had the APOE e4 variant. The group with the lowest risk had the APOE e2 variant, which has been associated with a decreased risk of dementia.
By the end of the study, 1,603 people with European ancestry developed dementia and 631 people with African ancestry developed dementia.
For people with European ancestry, researchers found that people with the highest scores in the lifestyle factors had a lower risk of dementia across all five genetic risk groups, including the group with the highest genetic risk of dementia. For each one-point increase in the lifestyle factor score, there was a 9% lower risk of developing dementia. Among those with European ancestry, compared with the low category of the lifestyle factor score, the intermediate and high categories were associated with 30% and 43% lower risk for dementia, respectively. Among those with African ancestry, the intermediate and high categories were associated with 6% and 17% lower risk for dementia, respectively.
Among people with African ancestry, researchers found a similar pattern of declining dementia risk across all three groups among those with higher scores on the lifestyle factors. But researchers said the smaller number of participants in this group limited the findings, so more research is needed.
“Larger sample sizes from diverse populations are needed to get more reliable estimates of the effects of these modifiable health factors on dementia risk within different genetic risk groups and ancestral backgrounds,” Tin said.
A limitation of the study was the smaller sample size among people of African ancestry and that many African American participants were recruited from one location.
The study was supported by the National Heart, Lung, and Blood Institute, the National Institutes of Health, the Department of Health and Human Services, and the National Human Genome Research Institute.
Reference: “Genetic Risk, Midlife Life’s Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study” by Adrienne Tin, Jan Bressler, Jeannette Simino, Kevin J Sullivan, Hao Mei, B. Gwen Windham, Michael Griswold, Rebecca F. Gottesman, Eric Boerwinkle, Myriam Fornage and Tom H. Mosley, 25 May 2022, Neurology.


Key features and details
- Rabbit polyclonal to SOX15
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-SOX15 antibody
See all SOX15 primary antibodies
DescriptionRabbit polyclonal to SOX15
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
- Transfected 293T cell lysate; human kidney tissue
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab55960 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 4 - 8 µg/ml.|
|WB||Use a concentration of 2.5 µg/ml. Predicted molecular weight: 28 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
FunctionBinds to the 5'-AACAAT-3' sequence.
Tissue specificityWidely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.
Sequence similaritiesContains 1 HMG box DNA-binding domain.
- Information by UniProt
- Protein SOX-12 antibody
- Protein SOX-15 antibody
- Protein SOX-20 antibody
Immunohistochemistry of (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling SOX15 with ab55960 at 4-8µg/ml. Arrows indicate positively labelled epithelial cells of renal tubules. Magnification: 400X.
Anti-SOX15 antibody (ab55960) at 1.25 µg/ml + transfected 293T cell lysate at 10 µg
HRP-conjugated anti-rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Gel concentration 12%
ab55960 has been referenced in 2 publications.
- Rui X et al. SOX15 regulates proliferation and migration of endometrial cancer cells. Biosci Rep 37:N/A (2017). PubMed: 28821564
- Proestling K et al. Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients. Reprod Biol Endocrinol 14:81 (2016). IHC-P ; Human . PubMed: 27881125