100,000 tons of sludge is produced annually in the Basque Autonomous Community (BAC) at waste water treatment plants (E.D.A.R). Under new legislation it will be obligatory to install these sewage water treatment plants in those urban areas of more than 3000 inhabitants, which in turn will mean, in the medium term, a considerable increase in the amount of sewage sludge generated.
The application of this sludge to forestry systems is being put forward as a solution to the ever-increasing production of this by-product of urban populations. The effects on crops and our natural resources that the application of this E.D.A.R. sludge might have should be thoroughly studied in order to preserve the environment and manage an organic residue such as this in a sustainable way. Thus, applications of treated sludge should avoid:
The transformation of waste sludge in soils is influenced by the properties of these, given the ongoing physical, chemical and biochemical processes therein. All these reactions affect the end-products of the breakdown in the soil and speed of such breakdown. Various studies of sewage sludge applications have shown that they affect the potential leaching of NO3 and a greater loss through NO3 leaching is experienced in those areas subjected to successive applications of the sludge than in those places untreated with sewage sludge. Nevertheless, more information is needed about the effect of such successive applications of sewage sludge regarding exactly where the nitrogen ends up in forest soils. This information is necessary in order to avoid NO3 leaching from taking place.
No study of the this use of sewage sludge on forest soils in the BAC has taken place to date, given the difficulty of the application of such material (the extensive land surfaces to be treated, the large quantities of sludge to be transported, a terrain difficult to work with machinery). One of the aims of this research was to study the NO3- y NH4+ ions in lixiviations after repeated applications of EDAR sludge on forest soil planted with Pinus radiata.
Garazi Andonegi | Basque research
Invasive Insects Cost the World Billions Per Year
04.10.2016 | University of Adelaide
Malaysia's unique freshwater mussels in danger
27.09.2016 | The University of Nottingham Malaysia Campus
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
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21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
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Introduction to Sitecore Mobile Web Development
Sitecore’s robust platform is built with the flexibility to easily create a mobile experience for website visitors. With device detection to know if your visitors are coming from their smartphones, tablets or desktops, Sitecore offers a simple way for web editors to maintain all website versions from one interface. According to Digital Trends, global mobile traffic is growing rapidly to include 13% of all internet traffic. This is why it’s more important than ever to maintain a mobile website for your brand. Recently I had the opportunity to use Sitecore while building a site for mobile devices.
If you already have a website built on Sitecore, half of your mobile site is already built. Depending on your mobile site requirements, you could potentially have a lot business logic that could be reused to build your mobile site. You will still need to provide a user interface design according to mobile device capabilities and network limitations. This means a layout system to support smaller displays, use small size images, adaptive layout structure to portrait or landscape positions of the device, among others.
Sitecore offers you a layout system that considers a schema to bring an appropriate response if the request was made from a mobile device. As you can see in the next screenshot, you could define as many devices as you want by filtering according to the browser agent.
If you have some experience developing with Sitecore you know that a best practice is to separate the components of a page into modules that you could reuse through the website, even between device versions of the site if the module is appropriate. However you may have to separate different layouts for desktop site and mobile site to provide the best experience to either one.
Once your layouts for mobile have been defined, it is necessary to add them to page templates. For example: think about which existing components you could use on your mobile site. Many small components, like a newsletter subscription module or auto-complete filter of products module, could be reused — of course, you need to provide different styles which can be done using different header modules for desktop and mobile that use different files for CSS. In the next screenshot, you can see the different mobile modules added to a page template that use a specific header for mobile.
For a desktop site, you could have a base layout as follows:
<%@PageLanguage="C#"AutoEventWireup="true" CodeBehind="Base Layout.aspx.cs" Inherits="Sample.Sitecore.Web.layouts.Master.Base_Layout" %> <!DOCTYPEhtml> <htmllang="en"> <headrunat="server"> <metacharset="utf-8"> <title>Sample | <%=pageTitle%> </title> <metaname="viewport"content="width=device-width, initial-scale=1.0"> <!-- Le styles --> <linkhref="/css/bootstrap.css"rel="stylesheet"media="screen, print"> <linkhref="/css/main.css"rel="stylesheet"media="screen, print"> <linkhref="/css/jquery.rating.css"type="text/css"rel="stylesheet" media="screen"/> <linkhref="/css/print.css"rel="stylesheet"media="print"> …
A mobile site’s layout has style references and scripts that help support mobile device requirements, like adaptation to device display, landscape and portrait modes, etc.:
<%@PageLanguage="C#"AutoEventWireup="true" CodeBehind="Mobile Base Layout.aspx.cs" Inherits="Sample.Sitecore.Web.layouts.Master.Mobile_Base_Layout" %> <!DOCTYPEhtmlPUBLIC"-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <htmlxmlns="http://www.w3.org/1999/xhtml"> <headrunat="server"> <title>Sample - Home</title> <metaname="viewport"content="width=device-width, initial-scale=1"> <linkrel="stylesheet"href="/mobile/css/jquery.mobile-1.2.0.css"/> <linkrel="stylesheet"href="/mobile/css/main_mobile.css"/> <linkrel="stylesheet"href="/mobile/css/bootstrap.css"/> …
With this, you could begin to build a mobile web version of your current site. However, you’ll need to take several things into consideration:
You need to provide a web design of your mobile site before you build the mobile version.
You need to define which components will be shared for the two versions of the site considering the information to be displayed and if the design is similar to both cases.
It's better to use different images for mobile site, smaller images will improve the performance. If you need to share images for both sites, you need to consider where the image will be displayed and its proportions (height and width) to avoid distort.
Note: This post doesn’t take into consideration responsive design that you could use to provide a different presentation for your site when is visited through a mobile device, that’s other topic. J


32 user programmable level sensitive chase effects. 16 independent cue stacks allow combinations of memory scenes and chases to be arranged as steps in a playback sequence.
Program precise fade times to each step or use the manual stack fader from step to step. Chase control functions include master level, rate, instant on/off or the fade rate between each chase step and the direction of the chase. Dual split dipless crossfaders proportionally vary the intensity of levels between scenes A and B.
Individual channel bump buttons with master bump level slider. Channel and scene bump button modes include momentary, toggle on/off, kill mode (allows only one button to toggle at a time) and solo mode which overrides console output except for the bump buttons that are pressed. Soft patch up to 512 dimmers. MIDI show control and SMPTE time code via MIDI to activate scenes. Fully protected non-volatile EEPROM memory (10 year retention).
Preheat function can be set from 0-20% of output level providing faster lamp response and longer lamp life Console locks include Record and Set up, which prevent unauthorized or accidental changes to programming or configuration. Width: 35 [88.9 cm].
Depth 15 [38.1 cm]. Height 4 [10.2 cm]. NSI 128 channel Micro-Plex out (3 pin XLR male and female)DMX512 digital control (female 5 pin XLR).
MIDI in/out/through (5 pin DIN). Audio in (RCA type female).Optional 37 pin 0-10 volt analog control port. Optional AMX192 out (4 pin XLR). The item "Leviton MC 7532 Controller 32/64 Channels- Stage Lighting (BRAND NEW)" is in sale since Sunday, April 25, 2021. This item is in the category "Musical Instruments & Gear\Stage Lighting & Effects\Stage Lighting Controllers".
The seller is "chrisgall7527" and is located in Pflugerville, Texas. This item can be shipped to United States.


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Service area: 150 miles
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Solar PV installation - Grid tied systems or Battery Backup.
We have provided solar systems for home owners and businesses seeking to reach net zero energy use.
We have installers that are certified as supervising Chicago eletricians and are in NASCEP training.
Ailey Solar Electric is a family-owned local solar energy system designer and installer. Our mission is to deliver cost effective solar electric systems to save residential and commercial customers money on their electricity bills while at the same time avoiding all the pollution with traditional electricity generation.


DB Regio has ordered 17 Coradia Stream electric multiple units for the Main-Weser subnetwork between Frankfurt, Giessen, Marburg and Kassel.
NEB has ordered 31 two-car, battery-operated Mireo Plus B trains from Siemens Mobility for the new East Brandenburg rail network.
Škoda Transportation Group has been chosen by Czech Railways to provide regular servicing of its electrical units.
Alstom has conducted a technical demonstration journey of its latest battery-powered train in Saxony, Germany.
eCon Engineering has conducted a research project into dynamic simulation solutions specifically suited to catenary wires.
Latvian State Railways and Škoda Vagonka have signed a contract for the supply of 32 new single-deck electric trains for Latvia.
Hitachi Rail Europe has announced that the bespoke electric commuter train which it has designed for ScotRail has received ‘Type Authorisation’ for operatio...


When it comes to hardware keyloggers, the new WiFi-enabled USB keylogger is by far the best keylogger available on the market. I have discussed why this device stands out in the sections below.
Like software keyloggers, hardware versions capture every keystroke typed by a user. However, they differ in a crucial aspect – you need to be physically present at the victim’s location for installation.
Also, they are easy to set up (plug and play), as there is no software to be installed on the PC or laptop and they operate in stealth mode.
Advantages of Hardware Keylogger
Hardware keyloggers offer several benefits over their software counterparts:
- No System Access Needed for Installation: Unlike software keyloggers, hardware keyloggers don’t require system-level access to be installed.
- Invisible to Security Scans: They remain invulnerable to security scanners, thanks to their physical nature.
- Massive Storage Capacity: With an internal memory of up to 2GB, these devices can store over a billion keystrokes.
One of the key perks of hardware keyloggers is that they don’t leave a footprint on the hard drive, making them undetectable by anti-spyware and eraser software.
See also: How to tap a cellphone
Features That Set Hardware Keylogger Apart
- Quick and Easy Installation: It only takes about 5 seconds to install – just plug it in, even if the computer is off.
- Encrypted Data Storage: The data inside the device is encrypted for added security.
- Operating System Compatibility: These keyloggers work seamlessly across various platforms, including Windows, Macintosh, and Linux.
- Resilient Data Backup: In the event of an operating system crash, the data stored in the keylogger remains safe and intact.
How Can a Hardware Keylogger Help You?
- Monitor employee productivity, including chats and website visits.
- Detect unauthorized access attempts and backup typed text.
For Parents and Spouses:
- Keep an eye on the websites your child visits and their overall web activities.
- Monitor a potentially cheating spouse’s online activities.
Types of Hardware Keyloggers
Choosing the right hardware keylogger can be crucial, depending on your needs and the type of keyboard you use. Whether it’s USB or PS2, there’s a suitable keylogger for each. Let’s take a closer look at the four main types of hardware keyloggers and their unique features:
1. USB Keylogger
USB Keyloggers are impressively compact and efficient. They boast a massive keystroke storage capacity, capable of storing over a billion keystrokes, all organized in an advanced flash FAT file system.
What makes them stand out is their Flash Drive mode, which allows for rapid data retrieval without the need for any additional software or drivers. They operate seamlessly, without affecting computer performance.
2. USB WiFi Keylogger (Best Hardware Keylogger )
The WiFi USB keylogger is a powerhouse of technology. It’s equipped with two processors, a complete TCP/IP stack, a WLAN transceiver, and a generous 2 Gigabytes of memory. Its standout feature is remote internet access.
This device can connect to a Wi-Fi network, email recorded keystroke data, and even allow real-time log viewing over TCP/IP. As mentioned earlier, this is by far the best hardware keylogger available on the market.
3. PS2 Hardware Keylogger
For those with PS2 keyboards, this keylogger is a perfect match. It comes with a large 2 Gigabyte memory and uses an advanced flash FAT file system. The keylogger provides a text menu full of options for data analysis and remains invisible during computer operations, evading detection by security scanners.
4. PS2 WiFi Hardware Keylogger
As the most advanced option for PS/2 keyboards, this keylogger shares similar memory and system capabilities as its USB counterpart. It stands out with its ability to connect to the Internet via a local Access Point. It can automatically send email reports with recorded data and offers on-demand access through TCP/IP for easy monitoring.
In wrapping up our exploration of hardware keyloggers, it’s clear that these devices offer a diverse range of functionalities suited to different requirements. Whether it’s the straightforward efficiency of a USB keylogger, the advanced capabilities of a WiFi-enabled device, or the specific compatibility with PS2 keyboards, there’s a keylogger for every scenario.
Remember, the choice of a keylogger should align with both your technical needs and ethical considerations. It’s crucial to use these devices responsibly and within the bounds of the law. With the right keylogger, you can achieve efficient monitoring while maintaining respect for privacy and security.
Ultimately, the world of hardware keyloggers is vast and varied, offering powerful tools for those who need them. By understanding the features and capabilities of each type, you can make an informed decision that best suits your monitoring objectives.
- Download Facebook hack tool
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The representation of SoftTie STRAPS products in a 3d player and augmented reality is an example of an ideal WebAR application in the industrial sector.
We offer a simple solution to present products online, integrated in websites, interactive.
„Our products are presented so much better.“ – Roman
© 2021 Mazing.
AGB & Impressum Web Agency Milano


Not so long ago researchers thought that RNAs came in two types: coding RNAs that make proteins and non-coding RNAs that have structural roles.
Then came the discovery of small RNAs that opened up whole new areas of research. Now researchers have come full circle and predicted that some long non-coding RNAs can give rise to small proteins that have biological functions. A recent study in The EMBO Journal describes how researchers have used ribosome profiling to identify several hundred long non-coding RNAs that may give rise to small peptides.
“We have identified hundreds of open reading frames in the long non-coding RNAs of humans and zebrafish that may give rise to functional proteins using ribosome profiling,” says Antonio Giraldez, one of the lead authors of the study and a professor at Yale University School of Medicine in the United States.
Ribosome profiling allows scientists to measure how much RNA is translated into protein. The method allows direct quantification of the messenger RNA fragments protected by the ribosome after digestion with the enzyme nuclease. The nucleases destroy the bonds between the exposed nucleotides that make up RNA and which are not protected by the protein-making machinery of the ribosome. What is left behind is a measurable amount of RNA destined to produce protein.
The researchers were able to visualize translation and the movement of the ribosome every three nucleotides, which corresponds to the size of each codon on the RNA producing an amino acid. This was possible by combining the high resolution of ribosome profiling with a bioinformatic tool developed in the Giraldez laboratory called ORFScore.
“Crucial to our study was the parallel use of a second computational method that relies on a bioinformatic tool called micPDP,” says Giraldez. “micPDP revealed that the RNAs identified by ribosome profiling correspond to peptides that have been conserved over the course of evolution. This strongly suggests that these genes encode proteins that have specific functions in these animals.”
As a further validation of their method, the scientists went one step further and used mass spectrometry to detect and characterize almost 100 of the peptides coded by the RNAs.
Until recently, long non-coding RNAs were thought to be restricted to the more mundane but nonetheless important structural roles that are essential to support the function of the cell. “We think the main reason that these small functional peptides have been missed in earlier studies is due to the assumptions that have to be made when assigning functions to large numbers of genes,” says EMBO Member Nikolaus Rajewsky, Professor at the Max-Delbrück-Center in Berlin, Germany, Director of the Berlin Institute for Medical Systems Biology and one of the lead authors whose team contributed the micPDP computational method to identify conserved micropeptides. “Short open reading frames are so numerous that by design standard genome annotation methods have to filter out short open reading frames.”
There are many short peptides in nature, for example neuropeptides or insulin, but unlike the small peptides arising from long non-coding RNAs they are produced as larger preproteins that need to be trimmed to their final size. The first reports of activities for the small peptides produced by long non-coding RNAs have already begun to emerge. Schier and colleagues recently reported in Science1 a small peptide that functions as a signal to promote cell motility in the early fish embryo. The aptly named Toddler protein arises from long non-coding RNAs and acts as an activator of a G protein coupled receptor, one of the essential signaling molecules in the cell. Earlier work showed that a long non-coding RNA produced by the tarsal-less/polished rice/mille-pattes gene encodes small peptides that control epithelial morphogenesis in Drosophila and the flour beetle Tribolium.
“Our identification of hundreds of translated small open reading frames significantly expands the set of micropeptide-encoding vertebrate genes providing an entry point to investigate their real life functions,” says Giraldez.
“The peptide predictions reported in these studies are tantalizing, but this is just the first step. Things should get really interesting as the community explores the functions of the predicted peptides in vivo,” says Stephen M. Cohen, Professor at the Institute of Molecular and Cell Biology in Singapore who is not an author of the paper. “I imagine that we’ll be hearing a lot about this new peptide world in the years to come.”
Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation
Ariel A. Bazzini, Timothy G. Johnstone, Romain Christiano, Sebastian D.
Mackowiak, Benedikt Obermayer, Elizabeth S. Fleming,Charles E. Vejnar, Miler T. Lee, Nikolaus Rajewsky, Tobias C. Walther and Antonio J. Giraldez
Read the paper:
1 Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors (2014) Pauli et al. Science 14 February 2014: 343 doi:10.1126/science.1248636
Further information on The EMBO Journal is available at emboj.embopress.org
Head | Public Relations and Communications
Senior Editor, The EMBO Journal
Tel: +49 6221 8891 407
EMBO is an organization of more than 1500 leading researchers that promotes excellence in the life sciences. The major goals of the organization are to support talented researchers at all stages of their careers, stimulate the exchange of scientific information, and help build a European research environment where scientists can achieve their best work.
EMBO helps young scientists to advance their research, promote their international reputations and ensure their mobility. Courses, workshops, conferences and scientific journals disseminate the latest research and offer training in techniques to maintain high standards of excellence in research practice. EMBO helps to shape science and research policy by seeking input and feedback from our community and by following closely the trends in science in Europe.
For more information: www.embo.org
Yvonne Kaul | EMBO
Genetic Regulation of the Thymus Function Identified
23.08.2016 | Universität Basel
Sun protection for plants - Plant substances can protect plants against harmful UV radiation
22.08.2016 | Max-Planck-Institut für Molekulare Pflanzenphysiologie
Scientists and engineers striving to create the next machine-age marvel--whether it be a more aerodynamic rocket, a faster race car, or a higher-efficiency jet...
Waveguides are widely used for filtering, confining, guiding, coupling or splitting beams of visible light. However, creating waveguides that could do the same for X-rays has posed tremendous challenges in fabrication, so they are still only in an early stage of development.
In the latest issue of Acta Crystallographica Section A: Foundations and Advances , Sarah Hoffmann-Urlaub and Tim Salditt report the fabrication and testing of...
Electrochemists at TU Graz have managed to use monocrystalline semiconductor silicon as an active storage electrode in lithium batteries. This enables an integrated power supply to be made for microchips with a rechargeable battery.
Small electrical gadgets, such as mobile phones, tablets or notebooks, are indispensable accompaniments of everyday life. Integrated circuits in the interiors...
Recent findings indicating the possible discovery of a previously unknown subatomic particle may be evidence of a fifth fundamental force of nature, according...
A nanocrystalline material that rapidly makes white light out of blue light has been developed by KAUST researchers.
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It's the little things here that mean a lot…
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All guest rooms come with a complimentary Handy smartphone with unlimited internet data, unlimited calls to 31 countries, useful travel apps & a comprehensive Hong Kong City Guide. Meeting the needs of our mobile and digital travelers with greater speed and efficacy, Handy 2.0 comes with a larger display screen, extended battery life and better photo quality.
COMPLIMENTARY MINI BAR
What's better than a mini bar? A complimentary one!
Stay connected with complimentary high-speed, wired and Wi-Fi internet around the hotel.
In room Nespresso coffee machines, pillow menus, sumptuous robes, printers, GP power banks, KEF wireless speakers & more, the list is endless…


I’m a graduate student in Computer Science at the University of Utah, working with Dr. Vivek Srikumar. I’m currently working on SweetPea, a programming language for experimental design with Dr. Vivek Srikumar, Dr. Matthew Flatt & Dr. Jonathon Cohen. In the past I’ve also dabbled in research in data visualization with Dr. Alex Lex, matrix analysis with Dr. Charles Johnson, and astronomy with Dr. Adam Bolton.
I attended the Recurse Center in Summer 2016, and have nothing but nice things to say about RC. If you’ve been thinking about applying, you should do it!
😟 → 🤖 → 😎
This is a Jekyll website based on the theme by Camille Diez.


In variation sites with minor reference alleles, overlooking the detection of homozygous reference genotypes results in inadequate identification of potential disease variants. Current variant calling practices miss these clinically relevant alleles warranting new approaches. More than 26,000 Eome Aggregation Consortium (ExAC) variants have a minor reference allele including 44 variants with known ClinVar disease alleles. We demonstrated how the current variant calling standards miss homozygous reference disease variants in these sites. We developed a bioinformatic panel that can be used to screen these variants using commonly available variant callers. We provide here a simple strategy to screen potential disease-causing variants when present in homozygous reference state.


Gbenga Oluwayomi (Prof)
Radio Operations Officer
Gbenga Oluwayomi, aka Prof as referred to by many is an On-Air Personality, Music Technologist, Emcee, and studio engineer with an exceptional uniqueness in anchoring Radio shows and live events. He has been on the radio since 2018 and has worked as a show host, co-host, producer, and beat reporter with Leadcity 89.1 FM, Apostolos Radio,and Radio IITA. Gbenga Oluwayomi(Prof) is currently the Radio Operations Officer and Presenter at the leading Agric Radio, 88.5FM, Radio IITA.


Latest Ice ages Stories
Melting ice sheets contributed much more to rising sea levels than thermal expansion of warming ocean waters during the Last Interglacial Period, a UA-led team of researchers has found.
Study on Jakobshavn Isbrae supports growing evidence that calving glaciers are particularly sensitive to climate change.
Fresh research into glaciers could help scientists better predict the impact of changing climates on global sea levels.
The last glacial maximum, which occurred 21,000 years ago, effects the current distribution of European scarab dung beetles; according to CSIC research, these results could help understanding the consequences of current climate change.
Finds that rocks used as key geologic evidence were formed deep within Earth millions of years after the ice age ended.
A team of scientists from the University of Sheffield and Bangor University have used a computer climate model to study how freshwater entering the oceans at the end of the penultimate Ice Age 140,000 years ago affected the parts of the ocean currents that control climate.
Cooling trend could be on the way unless thwarted by greenhouse gasses.
A set of maps created by the University of Sheffield have illustrated, for the first time, how our last British ice sheet shrunk during the Ice Age.
Russian scientists are set to pierce through Antarctica's frozen surface to reveal the secrets of an icebound lake that has been sealed deep there for the past 15 million years.
Researchers at the California Institute of Technology have discovered new details supporting the idea that mass extinction is linked to a cooling climate.
- A political dynamiter.


I need an Android app VR 360 videos and Images viewer.
only basic features needed
browsing and viewing 360 pics and videos using VR headset. must be compatible with Google VR cardboard
I would like it designed and built. you have to mail me codes used in app development seperately.


The molecule, which the researchers call cyanostar, was developed in the lab of Amar Flood, associate professor in the Department of Chemistry in the College of Arts and Sciences. It is described in an article in the journal Nature Chemistry, scheduled for publication in August and available online.
This model shows the five-sided cyanostar macrocycle capturing perchlorate at its center.
Credit: Amar Flood
Doctoral student Semin Lee is the lead author of the article, "A pentagonal cyanostar macrocycle with cyanostilbene CH donors binds anions and forms dialkylphosphate (3)rotaxanes." Flood and Chun-Hsing Chen, research crystallographer in the IU Molecular Structure Center, are co-authors.
"Macrocycles have been at the heart of molecular recognition experiments in recent years," Flood said. "But they're a dime a dozen. To make a contribution, you have to raise the bar."
Cyanostar raises the bar not only because it is easy to make, but for its unprecedented ability to bind with large, negatively charged ions, suggesting potential applications ranging from environmental remediation of perchlorate and molecular sensing of biological phosphates, to processes related to the life cycle of lithium ion batteries.
The creation follows from earlier work in Flood's lab showing that organic molecules could be designed to remove negatively charged ions from solutions. While the molecules have a neutral charge overall, their structure causes them to exhibit electro-positive properties and bind with weakly coordinating anions that were once thought to be incapable of being captured by molecular receptors.
Flood challenges graduate students to generalize the previous discovery of strong CH hydrogen bonds by creating molecules with similar yet complementary properties. In response, Semin Lee proposed using the cyanostilbene molecule as a building block for a new macrocycle -- a cyclic macromolecule with the capacity to bind ions. After false starts, he designed cyanostar, with a structure that resembles a five-pointed star.
A cross-section of the crystalline structure of cyanostar resembles the five-sided figures that Albrecht Durer showed in 1525 could be "packed" to tile a two-dimensional surface with periodic patterns. The form of the molecule and its fivefold symmetry are suggestive of Penrose tiles, geometrical forms that mathematicians have investigated in recent decades, and of quasicrystals, ordered arrays of atoms and molecules whose discovery in the 1980s changed the field of materials chemistry.
While chemists have created countless macrocycles, cyanostar is unusual in that it can be synthesized in a "one pot" process, without multiple, time-consuming steps. It is also atypical in that the synthesis produces high yields of over 80 percent, even as the quantity being produced increases to about 10 grams.
"That's quite unique," Flood said. "Normally, when you increase the amount of material you add to the reaction, the yield just drops off."
Shaped like shallow bowls, the molecules have a strong affinity for binding with large anions such as certain borate, chlorate and phosphate ions. The molecules bind in 2-to-1 sandwich-shaped complexes, with the anion sandwiched between two saucer-like cyanostars.
In addition to demonstrating its binding ability, the chemists showed cyanostar can be assembled into a dialkylphosphate rotaxane, a wheel-on-axle assembly in which a pair of macrocycles is threaded with a molecular rod, which is then capped on both ends by a "stopper." Rotaxanes are precursors of molecular machines and motors. Some can be manipulated -- for example, by applying light or heat -- to serve as chemical switches or to accomplish other types of work at the molecular level.
Support for the research came from the National Science Foundation (NSF/CHE-0844441). Funding for equipment used in the analysis is from NSF and the U.S. Department of Energy. To speak with Flood, please contact Steve Hinnefeld, IU Communications, 812-856-3488 or email@example.com.
Steve Hinnefeld | EurekAlert!
Scientists unlock ability to generate new sensory hair cells
22.02.2017 | Brigham and Women's Hospital
New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
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In this year’s Putney Debates, two online panel sessions were held on 8 December 2021. The first panel discussed the models of national unity, including the United States, the United Kingdom, China, Spain, and Italy.
Sionaidh Douglas-Scott Professor at Queens Mary College London
Richard Clary Lecturer at Harvard Law School (US)
Qianfan Zhang Professor at Peking University (China)
Francesco Bilancia Professor at Pescara University (Italy)
Roberto Galan Vioque Professor at Seville University (Spain)
Denis Galligan Emeritus Professor at Oxford University


The composite technology is very important for production of high-functional or high-quality materials and products. We have studied the composite technology in processing of polymers and glasses. In this paper, I mainly present the research topics of mixing process of polymeric materials and multi-layered process of polymer films. For the mixing process of polymeric materials, we have developed the computer simulation techniques to predict the materials behavior in a twin-screw extruder and have proposed the methods to evaluate the mixing performance in melt mixing based on the simulation results. Such techniques and methods were applied to the melt mixing in engineering problems. For multilayered process of polymer films, we have developed the simulation techniques of multi-layered flow for viscoelastic fluids and discussed the unstable problem and encapsulation phenomena at interface from the case studies considering die configurations, rheological properties, etc. The neck-in phenomena of multi-layered film could be also understood from simulation results in a die. We also studied the method to evaluate viscoelasticity of interfacial layer for multilayered film using the parallel plate rheometer experimentally. We proposed the non-stick length of interface as an evaluation index. For processing of glasses using polymer-inorganic composites, we proposed processing method to give functions to glass products by using the formable polymer-inorganic composit as a precursor.
All Science Journal Classification (ASJC) codes
- General Materials Science
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering


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Astronomers think that acidification inhibits the formation of stars and planets in the dust clouds. Now it is a case of waiting for precise measurements from the SRON-built HIFI space instrument that will be launched on the Herschel space telescope next year. Van der Tak: ‘I have already submitted my observation proposal’.
The formation of stars and planets in the universe is a delicate process. Clouds of gas and matter rotate and draw together under the influence of gravity. Pressure and temperature then rise, which eventually leads to the kindling of a new star with planets potentially orbiting it. Yet why does this happen at some locations in the universe and not at others? What are the conditions for star and planet formation? How does this process start and when does it stop? Astronomers are fumbling in the dark.
‘The quantity of charged molecules in the dust cloud appears to have an inhibitory effect’, says Floris van der Tak. ‘These ensure that the magnetic fields can exert a greater influence on the cloud, as a result of which the entire cloud becomes agitated and the star-forming process is disrupted’. Observing these charged molecules directly is difficult. The ratio of acidic water molecules to ordinary water molecules is a measure of the quantity of charged molecules.
However, it is difficult to observe water molecules from under an atmosphere that is itself predominantly made up of water molecules. ‘It is like looking for stars in the daylight.’ On Earth it can only be done from a high mountain where the air is rarefied. Such a spot is the 4092 metre-high top of the Hawaiian volcano Mauna Kea, where the James Clerk Maxwell Telescope is located. Van der Tak focused this telescope on the Milky Way galaxies M82 en Arp 220, where he discovered areas rich in acidic water molecules.
‘Amazingly, what causes these acid water molecules to be present in both Milky Way galaxies is completely different’, says Van der Tak. ‘In Arp 220 they develop under the influence of X-rays in the vicinity of the central supermassive black hole. In M82, the cause is the ultraviolet radiation emitted by hot young stars in the star-forming area. Therefore, in these particular galaxies the process of star formation inhibits itself, due to more and more charged molecules being created.’
The astronomer will be able to deploy even heavier equipment for his research in the not too distant future. Next year, the European Space Agency (ESA) is launching the Herschel space telescope with the SRON-constructed Heterodyne Instrument for the Far Infrared (HIFI) attached to it. And in the 5000 metre-high and completely arid Atacama Desert in Chile, a start has been made on the construction of ALMA, 66 smart telescopes that can together produce detailed maps of the Milky Way galaxies. SRON is one of the partners involved in developing the detectors for these telescopes.
The results of the research of Floris van der Tak and his collegues Susanne Aalto of the Chamlers University of Technology, Onsala Sweden and Rowen Meijerink of the University of California are published this week in the scientific journal Astronomy & Astrophysics.
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When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
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Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
Scientists developed specially coated nanometer-sized vehicles that can be actively moved through dense tissue like the vitreous of the eye. So far, the transport of nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. The work was published in the journal Science Advances and constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.
Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international...
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Please use this identifier to cite or link to this item:
|Title:||DIFFERENTIAL EVOLUTION-BASED METHODS FOR NUMERICAL OPTIMIZATION||Authors:||QIU XIN||Keywords:||Evolutionary Algorithm,Differential Evolution,Multi-objective Optimization,Minimax Optimization,Numerical Optimization,Robust Optimization||Issue Date:||11-Aug-2016||Citation:||QIU XIN (2016-08-11). DIFFERENTIAL EVOLUTION-BASED METHODS FOR NUMERICAL OPTIMIZATION. ScholarBank@NUS Repository.||Abstract:||This thesis focuses on designing new Differential Evolution (DE) variants to overcome the limitations of existing approaches in solving single-objective, multi-objective and minimax optimization problems. First, a multiple exponential recombination strategy is proposed to fill the research gap in DE crossover operator development. The new strategy is able to inherit all the main advantages of existing crossover operators while possessing a stronger ability in handling dependent variables. Next, a novel multi-objective DE algorithm is designed for circumventing the convergence slowdown, parametric sensitivity and lack of flexibility issues while extending DE to multi-objective optimization. Last, the minimax optimization problems in robust design are investigated. A new minimax DE algorithm is developed to efficiently address the fundamental issues in current minimax optimization area. Besides the statistical superiority over other state-of-the-art approaches, the new algorithm is also successfully applied to solve two open problems in robust control.||URI:||http://scholarbank.nus.edu.sg/handle/10635/134464|
|Appears in Collections:||Ph.D Theses (Open)|
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Test for independence between time to failure and cause of failure in competing risks with k causes
Journal of Nonparametric Statistics
In this paper, we develop a simple nonparametric test for testing the independence of time to failure and cause of failure in competing risks set up. We generalise the test to the situation where failure data is right censored. We obtain the asymptotic distribution of the test statistics for complete and censored data. The efficiency loss due to censoring is studied using Pitman efficiency. The performance of the proposed test is evaluated through simulations. Finally we illustrate our test procedure using three real data sets.
Anjana, S.; Dewan, Isha; and Sudheesh, K. K., "Test for independence between time to failure and cause of failure in competing risks with k causes" (2019). Journal Articles. 886.


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CROSSOVER(CLOSE, PSAR(0.02, 0.2)) = TRUE
CROSSOVER(PSAR(0.02, 0.2),CLOSE) = TRUE
will it give alert when PSAR start trending , i mean when it show the 1st tik , because i do see 1st tick when second candel is already started .
the code is giving lots of singnals in opposit direction , trend is up based on PSAR but yet it is giving sell signals … I need code when PSAR gives 1st trend signal .


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Behavioral endocrinology and systems neuroscience increasingly benefit from integrating data across levels of organization in order to gain insights into the neural basis of behavior. While imaging and genetic approaches have long complemented electrophysiological analyses, it has now also become possible to conduct molecular level experiments in a diversity of model systems. For the past 35 years, the Neural Systems & Behavior course at the Marine Biological Laboratory has established itself as the premier discovery-driven training opportunity for the next generation of neuroethologists and systems neuroscientists. More recently, efforts have been directed toward the incorporation of molecular and genomic approaches with the traditional behavioral and electrophysiological approaches. Building on a successful collaborative project in 20131,2, we now expand the teaching module. We developed intellectuallystimulating yet robust and feasible procedures that integrate both in vitro and in vivo physiology preparations, with either quantitative real-time PCR or immunohistochemistry for the subsequent measure of gene expression. As the eight-week course is divided into four two-week cycles, the preceding cycles offer students a series of different preparations and topical questions during which behavioral and physiological studies generate samples appropriate for subsequent integration of molecular techniques. Students’ molecular projects are conducted not only to genetic model systems (e.g. flies and mice), but also classical models of neuroethology (e.g. leech, crustaceans, electric fish), in order to integrate a molecular understanding with learning and memory, mating behavior, central pattern generators etc. The projects are made robust through advance testing of protocols and reagents that complement the physiology experiments. Yet students also learn design, optimization and potential project extension through prepared exercises. The integration of molecular techniques now allows the course to more fully accomplish the course goal to expose students to diverse approaches to the investigation of the neural basis of behavior.


The Manette Grande pendant light by Tech Lighting is an elevated version of the classic cylinder pendant. with its simple cylindrical design and added sleek metal bands, the Manette Grande exudes style and simplicity. This hand-blown pendant can be customized via several color combinations to match your unique preferences. Available color options include Clear, Smoke, White and Transparent Smoke. Three on-trend hardware finishes are available along with your choice of energy efficient LED lamps. Due to its larger size, the Manette Grande is ideal for kitchen island task lighting, dining room lighting and home office lighting applications. Your choice of 5 upper and lower glass and acrylic color combinations allow opportunity for incredible personalization. LED light sources fire simultaneously up and down to evenly illuminate the glass while contributing both direct and indirect illumination.
- European artisanally crafted hand-blown glass
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- Complementary Manette low-voltage and Manette ceiling fixture available by Tech Lighting
- Ideal for kitchen island task lighting, dining room lighting and bedroom lighting
- High quality, long-lasting integrated LED lamping included to save you time and money
- Protected by a 1-year warranty
Includes 18 watt, 925 delivered lumen (725 lumens down/200 lumens up) LED modules. Dimmable with most LED compatible ELV and TRIAC dimmers. Ships with twelve feet of field cuttable cable.
*Image shown is for Illustration purpose only, actual product's color/finish/option may vary.
*This item is excluded from sale events and not available for additional discounting or promotional offers.


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Chris Woolard BSc Phd (Cape Town)
Chris Woolard graduated with a PhD from the University of Cape Town. He has lectured at the University of South Africa and the Nelson Mandela Mandela Metropolitan University in Port Elizabeth.
Currently he is employed as a principal scientist by Sasol Technology at the Sasol Advanced Fuels Laboratory on the campus of the University of Cape Town. He is also a part-time lecturer of postgraduate courses at the Centre for Materials Engineering and in the Departments of Mechanical Engineering and Chemical Engineering.
He has significant experience in Materials Science, particularly focused on research in rubber science and technology for various tyre manufacturers, motor vehicle manufacturers and synthetic rubber producers. He was a founding member of Rubber Nano Products which has developed a nanomaterial for rubber modification. His research has also spanned a wide variety of other polymer and materials science activities. These include materials for solar science, particulate polymer composites, methods for polymer characterization and polymer waste utilisation.


NETPOWER MOBILE integrates a worksurface with a tablet stand to allow an easy use of electronic devices in the classroom. The tablet may be used in portrait and landscape position. The chair with casters also includes a battery to charge any electric device.
- Rotating worksurface
- Charges any electronic device
- Casters for mobility


RarmaRadio Pro 2.72.7 Multilingual | 12.8 Mb
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The Experimental and Translational Immunomics Research Group, established in July 2012, conducts multidisciplinary research in the fields of immunology and genomics, with most of its efforts focused on the analysis of CD8+ T cell homing, immigration of CD8+ T cells into distinct tissue environments, phenotypic plasticity of Cd8+ T cells in different tissues, and regional immunity maintained by CD8+ T cells. The group investigates these questions using automated isolation of tissue-resident CD8+ T memory and effector cells, genomic scale description of their organ-specific characteristics, and tracking in vivo T cell activity and movement, using both transgenic mouse models and human clinical samples.
The research group typically uses the following methods and approaches :
Murine experimental acute GvHD model (Actm-OVA/OT-I)
Human patiensts diagnosed with acute GvHD
Murine experimental H1N1 flu infection model (A/PR/8/34)
Adoptive T cell transfer
In vivo T cell tracking
Automated tissue dissociation
Automated MACS sorting
Whole genome gene expression profiling
In vitro CD8+ T cell acivation
In vitro CD8+ T cell killing assay
Research infrastructure, equipment, transgenic mouse strains
Sufficient wet lab space, an automated tissue dissociation platform (Miltenyi Biotec gentleMACS Octo with Heating Upgrade), an automated magnetic cell sorting system (Miltenyi Biotec AutoMACS Pro), multiple BSL2 and BSL1 laminar flow hoods (Esco), a refrigerated Eppendorf centrifuge (Heraeus Fresco 17), desktop centrifuge (Heraeus Megafuge 16R), and sufficient storage capacity (liquid N2 tank, -80C freezer, -20C freezers, 4C fridges) are readily available. Besides, the group maintains several transgenic mouse strains, as follows (all on the C57Bl/6 backround): OT-I, Act-mOVA, CD45.1, UBC-GFP. Potential collaborators are encouraged to contact the group leader; we have several ongoing collaborations using the above infrastructure.
|Dr. Zoltán Pós, Associate Professor|
|Nikolett Lupsa, Research Fellow|
|Dr. Barbara Molnár-Érsek, Senior Research Fellow|
Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity.
Érsek B, Silló P, Cakir U, Molnár V, Bencsik A, Mayer B, Mezey E, Kárpáti S, Pós Z, Németh K.
Cell Mol Life Sci. 2020 Apr 23. doi: 10.1007/s00018-020-03517-8. PMID: 32328671


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In 2005, scientists from various science centres in Spain, Germany, Switzerland, Australia, the United States and Chile created the Mountain Invasion Research Unit (MIREN) in order to study the distribution of exotic species in high mountain species and to design experiments to confirm the invasive capacity of certain species in high mountain environments.
"These plant communities in Alpine environments have until now not been thought particularly vulnerable to this kind of environmental disturbance", José Ramón Arévalo, one of the authors of the study and a researcher at the Department of Ecology of the University of La Laguna, tells SINC. However, the experiments show clearly "that the beliefs about this supposed protection and mountain species' resistance to invasive species is erroneous", he adds.
The study, published recently in Frontiers in Ecology and The Environment, and which is part of the work done by MIREN, has made it possible to identify the factors that make plants in these areas more vulnerable to invasion by other species.
Among other factors, the scientists stress the ease of movement of propagules (plants which can reproduce asexually in order to produce new plants) as a result of human activity and the increase in environmental disturbance, the low levels of biological resistance of invaded plant communities, the increase in transport between high mountain areas that are far apart from each other, and the risks according to climate change models, "which will make it easier for invasive plants to establish themselves and reproduce", the ecologist explains.
A work agenda to stem invasions
The work carried out over the last five years shows that "invasions may be a factor in more extensive and serious disturbance than had ever been thought", says Arévalo. The scientists also say there is a need to establish a work agenda to evaluate "not only current invasions, but also those that could happen in the future in mountainous environments", warns the researcher.
Protecting against and above all preventing invasions could be done by means of experimental and modelling work. Arévalo says "biological invasion is not a fact, but rather a process of species overlapping within a habitat, which means prevention is much more effective and viable than eradication".
Pauchard, Anibal; Kueffer, Christoph; Dietz, Hansjoerg; Daehler, Curtis C.; Alexander, Jake; Edwards, Peter J.; Arévalo, José Ramón; Cavieres, Lohengrin A.; Guisan, Antoine; Haider, Sylvia; Jakobs, Gabi; McDougall, Keith; Millar, Constance I.; Naylor, Bridgett J.; Parks, Catherine G.; Rew, Lisa J.; Seipel, Tim. "Ain't no mountain high enough: plant invasions reaching new elevations" Frontiers in Ecology and The Environment 7(9): 479-486 noviembre de 2009.
SINC | EurekAlert!
Conservationists are sounding the alarm: parrots much more threatened than assumed
15.09.2017 | Justus-Liebig-Universität Gießen
A new indicator for marine ecosystem changes: the diatom/dinoflagellate index
21.08.2017 | Leibniz-Institut für Ostseeforschung Warnemünde
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
19.09.2017 | Event News
12.09.2017 | Event News
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22.09.2017 | Medical Engineering
22.09.2017 | Physics and Astronomy
22.09.2017 | Physics and Astronomy


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