I've had depression and anxiety problems since I was very young. I can't remember which started first. I haven't recieved any real good care for it, infact I've only tried twice, the first was with a counselor with the mind of a duck, and the second was a clinical study. At the study, we decided that it seemed like what would help my depression is a structered schedual and planned activites. However, those are the exact things that i have anxiety about. i had a lot of attendance problems in school because of it. there we days when id consider breaking a limb on purpose just so i wouldnt have to go. is there anything you can think of that might help both?
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Information about Cenforce 100 mg
Cenforce 100 mg is a generic medicine that can help men with weak erections. Weak erections are the result of poor blood circulation. In this way, the use of erectile dysfunction drugs works like a miracle for men. With PDE-5 inhibition, it provides the energy needed to produce strong erections for many hours.
Cenforce comes in much different strength and helps men improve their sexual performance with ease. This common medication is quite affordable and effective in treating erectile dysfunction.
How does Cenforce 100 mg medicine work?
Erectile dysfunction is a painful condition in men. It doesn't move them forward in their sexual journey. Now, if you are one of those who are having difficulty then here is the solution. With the help of Cenforce 100, the blue pill has a good blood flow absorption effect.
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How to use Cenforce 100?
The ingredients of Cenforce 100 mg include sildenafil citrate. An active ingredient for men to help cure erectile dysfunction. It is also known as impotence when due to poor blood circulation, men cannot get an erection during sex.
The main use of Cenforce 100 is to treat erectile dysfunction (ED) as well as pulmonary arterial hypertension (PAH). They are available for both conditions and with one dose consumed, the condition will be in place.
Side effects of Cenforce 100 mg
All medications have side effects ranging from mild to severe. Cenforce 100 USA is no different and its side effects range from mild to undesirable. Note that users are more likely to experience these side effects if not taken properly or as prescribed.
- Respiratory tract infections
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Warnings and precautions
With Cenforce 100 mg (Sildenafil Citrate) time-consuming tablets or any other erectile dysfunction medication, men should ensure to follow the safety measures mentioned below. Medicines containing nitrate concentrations interact with Cenforce 100 mg. This may mainly include isosorbide mononitrate.
Reports have confirmed that Cenforce 100 mg interacts with certain supplements. This can harm sexual performance. Experts here recommend managing the disease with necessary steps or instructions.


BiocytogenTM at the American Society of Hematology Meeting 2017 exhibit floor Biocytogen displayed its full range of services to the scientists and physician scientists that attended the American Society of Hematology National Meeting. Over 25,000 professionals and clinicians attended the meeting; a large part of the exhibits focused on novel treatments and therapies for hematological disorders and blood cancers. Some of our most popularly discussed products were our humanized immune-checkpoint animal models which are excellent tools for the development of immune-oncologic treatment strategies. Checkout our full series of humanized immune-checkpoint animals at http://www.biocytogen.com/second/103.html
Dr. Amalia Ávila, Dr. Jie Xiang, Dr. Jian Ni and Dr. JamesJin at Biocytogen's booth at the American Society of Hematology Exhibition Floor.


Effects of Endocrine Disruptors compared with Abnormalities of Schizophrenia
2009 Study Abstract
In recent years, numerous substances have been identified as so-called “endocrine disruptors” because exposure to them results in disruption of normal endocrine function with possible adverse health outcomes.
The pathologic and behavioral abnormalities attributed to exposure to endocrine disruptors like bisphenol-A (BPA) have been studied in animals. Mental conditions ranging from cognitive impairment to autism have been linked to BPA exposure by more than one investigation. Concurrent with these developments in BPA research, schizophrenia research has continued to find evidence of possible endocrine or neuroendocrine involvement in the disease.
Sufficient information now exists for a comparison of the neurotoxicological and behavioral pathology associated with exposure to BPA and other endocrine disruptors to the abnormalities observed in schizophrenia.
This review summarizes these findings and proposes a theory of endocrine disruption, like that observed from BPA exposure, as a pathway of schizophrenia pathogenesis. The review shows similarities exist between the effects of exposure to BPA and other related chemicals with schizophrenia. These similarities can be observed in 11 broad categories of abnormality: physical development, brain anatomy, cellular anatomy, hormone function, neurotransmitters and receptors, proteins and factors, processes and substances, immunology, sexual development, social behaviors or physiological responses, and other behaviors. Some of these similarities are sexually dimorphic and support theories that sexual dimorphisms may be important to schizophrenia pathogenesis. Research recommendations for further elaboration of the theory are proposed.
… “Evidence that prenatal estrogen exposure may have the opposite effect than in adulthood emerged from reports of psychosis in patients prenatally exposed to the synthetic estrogen, diethylstilbestrol (DES).” …
… “The author chose to compare the endocrine-disrupting effects of BPA and a few other selected endocrine disruptors to schizophrenia primarily because there is substantial BPA-related literature available for review, and highly controversial claims have been made that BPA could be involved in other mental problems or psychiatric illnesses such as autism and attention-deficit hyperactivity disorder (ADHD). In addition, a recent government-sponsored panel expressed concern that BPA can impair normal neural and behavior development in fetuses, infants, and children.” …
… “In that study, BPA also increased gene expression of dopamine (DA) transporter in adult rats after neonatal exposure. The exposed rats were hyperactive, and the investigators proposed the hyperactive rats as possible models of autism or ADHD.” …
- Read and download the full study (free access) Effects of Bisphenol-A and Other Endocrine Disruptors Compared With Abnormalities of Schizophrenia: An Endocrine-Disruption Theory of Schizophrenia, on the NCBI, PubMed, PMC2643957, 2009 Jan.
- Image credit Institut Douglas.


Second Trimester Scanning
The second routine scan that you will be offered is around 18-21 weeks of pregnancy and this is commonly called the anomaly scan. It doesn’t really sound particularly comforting!
It’s looking to see if your baby may have any of a number of medical conditions that can be seen on pregnancy scans. Scans can’t pick up everything, so unfortunately, they cannot confirm for sure that your baby won’t have any medical conditions, so if you are concerned about a specific condition, perhaps one that’s in your family, you may need to ask whether it’s something that might be able to be seen.
This 18-21 week scan also looks for the location of your placenta which ideally and in a majority of women, will be well away from the cervix. Sometimes they may see that your placenta is what’s called ‘low lying’. A low-lying placenta means that it is close or closer to your cervix. Even if it is closer to your cervix, or partially touching the cervix, it often moves upwards and away as your pregnancy progresses.
How does it move I hear you say!
It doesn’t move by itself. Your womb is an amazing organ and grows from the size of a pear, to just below your rib cage during your pregnancy. To do this the muscles work very differently to other muscles in your body.
The lower down muscles of your womb called the lower segment, do not start growing till the third trimester. When this area starts to grow, anything above moves up higher! So if your placenta is lower down, when the lower segment grows, your placenta moves upwards. This lower segment of the womb can grow by up to 10cm!
You will be offered another follow up scan around 32 weeks to check that this has happened. You may also be offered a second one at 36 weeks.
Sometimes the person doing the scan (sonographer) may not be able to see part of your baby, for instance if they are lying in a difficult position to see. Or, they may think they’ve spotted something, but they’re not sure, and you may be asked to come back for another scan later on, which can be very worrying. You can ask as many questions as you like and seek support from your midwife if you want to, before you go for a follow up scan.
If a medical problem is found, depending on what the problem is you may be offered further scans as your pregnancy progresses.
During the anomaly scan the sonographer may be able to tell you the sex of your baby, however many hospitals are not offering this anymore, as the reason for the scan is to check for health conditions, not to see the sex of your baby. Even if you do choose to find out, it’s not going to be 100% certain! If you do not want to know (in case they can see easily) make sure you let them know that you do not want to find out, to stop an accidental he or she mentioned!


New electronic health records effort gets good start in stateMar 14, 2012 Staff
Encouraging the use of electronic health records by Wyoming healthcare providers is the goal of the Wyoming Department of Health's Medicaid Electronic Health Record Incentive Program.
The federally funded EHR incentive program was authorized under the Health Information Technology for Economic and Clinical Health (HITECH) Act, a part of the American Recovery and Reinvestment Act of 2009.
"EHR technology can help Wyoming's healthcare providers see an increase in productivity for their practice," said Teri Green, state Medicaid agent with the Wyoming Department of Health.
According to Rural Assistance Center, health information technology has the potential to transform healthcare.
Integrating a patient's health information into an electronic health record (and health information exchange offers multiple opportunities for benefits such as: improving patient care, improving efficiency and reimbursement and improving health.
Since launching in December 2011, Wyoming has had 69 providers and nine hospitals register for the program through our state-level registry.
The Wyoming Department of Health has approved federal payments of approximately $4.5 million in incentive funding to nine hospitals and 29 other providers that have attested to adopting, implementing or upgrading an EHR.
"We see the potential for some very real benefits in Wyoming through the adoption of electronic health records," Green said. "For example, we believe EHR technology will help our provid-ers connect more easily with telehealth options, which provide enhanced access to care for rural Wyoming citizens."
Eligible medical professionals can receive up to $63,750 over the six years they choose to participate in the program.
To be eligible for the program providers must have a 30 percent Medicaid patient volume in a 90-day reporting period or 20 percent for pediatricians.
Eligible providers may still participate in the program and receive incentive payments for the 2011 calendar year until March 30.
The last year to register for the program and receive the full $63,750 payment will be 2016.
For more information on Wyoming's EHR incentive program, visit http://www.wyomingincentive.com/ online.


We all have heard that we should accept our current circumstances or issue and be happy with the way things are. Unfortunately, just telling yourself to accept the way things are, doesn’t actually work much for you; does it? At the end of the day, words are just words. Most importantly, thinking you have accepted your problems even when you are only struggling with them will lead to more frustration and dissatisfaction with your current mind state.
Obviously ignoring the issue stops you from worrying about it, but only for a little bit. You can go days, weeks, even months ignoring a pending issue in your life. When you ignore a problem, you only create more pain and frustration than you began with.. When a person who under stress decides to drink alcohol to block the difficulties, it definitely works till the next day, so when bad feelings come, he drinks again. So far so good, short term. In the long run, however, that person will develop a bigger problem of addiction. The more you avoid, the weaker you feel.
When our stress isn’t handled, our minds and bodies are affected. When you feel frustration, anger, or pain your body’s nervous system tells your heart rate to increase, raising your blood pressure. There are various healthy ways of expressing yourself when issues arise in your life; we just need to find one. But it is possible only when your mind settles and detaches you from the events and thoughts you come across, you will be able to quickly deal with and accept your feelings.
Many of us struggle to recognize and accept our emotions and therefore are not in a position to manage our emotions in a helpful manner. Even If we do notice our distressing emotions, we often don’t accept them, because we don’t like the idea of being angry or anxious or jealous, it doesn’t fit with our self-image or we worry that other people won’t like it. Your emotions will be under your control when you become completely aware of them. When you’re confident and secure with yourself you will be able to validate and accept your feelings.
Acceptance means that you don’t have to spend your energy pushing the emotion away. When you accept the emotion, you are giving yourself a chance to learn about it, become familiar with it, become skilled in its management, and integrate it into your life. Understanding, accepting, and working with reality is both practical and purposeful denying your current reality will not make it make it go away. Remember, you will never be able to create the right reality if you aren’t willing to let the wrong reality go. Dealing with the bad stuff is a way to get to the good stuff–but it takes practice & practice. You have the strength within to realize you control your reality and you’re the only one who can change it.


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Whoo hoo, we’ve finally had some good sunshine last week! Which, of course, means that I had decent lighting for my post-run selfies! 😉
Last week was kind of crazy. I waited until the last minute to start studying for a Nutrition exam, so I of course just about wore myself out cramming for it! It definitely wasn’t my best plan! Needless to say, by the time Thursday rolled around, I was exhausted. So I had a slow morning then ran a couple miles, and lifted! I was even able to run up a hill that I’ve been having to walk up. Granted, I did have to walk for minute at the top. But hey, it’s progress right?! Note to self: don’t take a year off of running…. After getting a little extra rest, and taking some time for a workout, I came back to life. I caught up on farm work over the weekend, and studied a lot of course!
We are all busy! But we can’t get so busy that we forget to make for ourselves. Not making time for rest, exercise, and healthy eating will cause everything else to crumble. I know that sounds dramatic, but it’s true. How can you take care of everything you have to do in life, if you can’t take care of you? Don’t be the last thing on your to-do list! Take care of yourself, so that you can better take care of the all the things you need to take care of. I have struggled a lot with this since school started back. It’s so hard to make time for my workouts, and cook healthy meals when I have to study so much. And I am so not exaggerating the studying! I mean having to memorize 180 bones kind of studying! I have plenty of excuses to not make my physical, mental, and emotional health a priority. But, I can’t let myself make excuses because I also don’t have time to feel bad! I don’t have time for low energy, grumpy moods, and feelings of anxiety and overwhelm. I have bones to learn, for goodness sake!
My point of this post is to encourage you to take time for yourself this week! Don’t put yourself last! Do what you need to do to rest and recharge. You deserve to feel good physically, mentally, and emotionally! You deserve to be a priority!! I hope you all have a great week!
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Daily Sun Face Lotion
Anti aging sun protection.
- Our non greasy formula combines the best of our anti aging ingredients with a strong UV broad spectrum protection and blocking made with non nano zinc.
- This formula is safe to use daily on pregnant, breast feeding, on children, sensitive skin.
- A little goes a long way as it is easily spreadable. It’s a generous size jar of long lasting, skin delicious and protecting ingredients. This jar will last you twice as long as other competitor brands because of the way it spreads on the skin. You don’t need much.
- This daily sunscreen has 40 SPF with non nano zinc + the natural UV protection in the ingredients including coconut and jojoba totaling about 45 SPF.
*Because we use 0 chemical preservatives or chemicals and because of the coming hot summer months, the lotion may be a loose consistency from the heat while in transit or kept in a warm room, much like how coconut oil acts. To restore its consistency, let it sit and store in a cool area. Regardless of the consistency, nothing is wrong with it being loose and will apply and protect the same. The delicious oils are just softer now. If you would like it to be at a more solid consistency, please keep stored on the fridge.
Tips For Use:
Start with a very little dab on your finger, dab around your face and rub in thoroughly. You do not need a lot for full coverage.
Our favorite place to store our Daily Sun Lotion is in the fridge! It keeps it fresh and cooling, awakening your morning skin.
CARE FOR YOUR NATURAL PRODUCTS IN THE SUMMER MONTHS:
If you live in a hot climate, please make sure you are tracking your package so your product doesn’t sit in the sun. Cosmetics and skincare can melt.
Once you get package, open and place skin care in a cool place like a bathroom for a few hours before opening. The products will most likely need to come back to their consistency in a temperature controlled environment. Because we use zero chemical preservatives, and delicious organic oils, natural products can become loose and will need a couple hours to stabilize again. Nothing is wrong with your product if it’s loose, it applies and works the same, it’s just a different consistency -think like coconut oil. -With love, The BCN Team.
Active Ingredients: Non Nano Zinc
Inactive Ingredients: *Juice of Aloe Barbadensis, *Cocos (Coconut) nucifera, Organic Alcohol,*Hexadecan-1-ol (Cetyl Alcohol), NON GMO Wax of
Helianthus Annuus (Sunflower)(cold pressed high oleic), Magnesium Stearate, Glycerine (Glycerin), *Simmondsia chinensis (Jojoba), *
Olea Europaea (Olive), Extracts of: *Aspalathus Linearis (Rooibos), *Salix alba (White Willow Bark), *Rosmarinus (Rosemary), Methylsulfonylmethane, Dimethylaminoethanol Bitartrate, Tocopherol, *Azadirachta indica (Neem), Helianthus annuus (Sunflower High Oliec)
Xanthomonas campestris (Xanthan). *Organic
The alcohol combo in all our products is non drying, non irritating formula made with food grade fatty alcohol acting like an emollient, and with organic preserving and ingredient penetrating ethanol is quite moisturizing making our products formulated different than those with traditional alcohol.
Certified organic alcohol, also known as ethanol (not to be confused with isopropyl, or rubbing alcohol), is said to be able to extract more phytochemicals than other substances used for extraction, such as glycerin, propylene glycol or water. With a wider spectrum of botanical phytochemicals present, the end product is richer, more opulent and high potency of key ingredients. Organic Alcohol is also an effective emulsifier and carrier, helping ingredients penetrate the skin. Objections to alcohol in skin care products usually cite the tendency of alcohol to dry the skin. We have purposefully formulated our ingredients so the alcohol balance is safely preserving our products naturally, while to not be drying.
Cetearyl Alcohol Facts: Not only is it considered safe and nontoxic for use on the skin and hair, but it's also not drying or irritating like other types of alcohol. Due to its chemical structure, cetearyl alcohol is even permitted by the FDA as an ingredient in products labeled “alcohol-free.”
I live in a humid climate so separation occurred but I just kept it in the fridge and it has been perfect for everyday use! It’s light weight and doesn’t leave a white cast at all. Very pleased will be purchasing again :)
The only facial sunscreen that doesn’t make my skin brake out! A little goes a long way! Love this product so much!!
Does not feel like any other sunblock I’ve ever used! So moisturizing and love the glow! A little goes a long way!
My daughter told me about this as I do not like to put sunscreen on but realize the importance pf wearing some. This goes on very nicely, I don't feel "hot" wearing it and knowing it is natural and protecting and moisturizing my skin is an added plus.
while it could be a little more moisturizing, i love that there is no weird whiteness to my skin and it doesnt leave a sticky sunscreen feeling. and i hasnt made me breakout!


The MTHFR gene variant is a genetic mutation that many people have. Studies have shown that up to 50% of the population may be affected. 1
The MTHFR mutation affects everything from the body’s ability to remove toxins all the way to immune function.
It’s especially common for kids who have autism. One study concluded that up to 98% of autistic kids have some form of MTHR SNP (another way to say gene variant). 2
You can read more about MTHFR and what it means and what you can do it about here: MTHFR Made Simple
Today, I want to share how MTHFR can affect your autistic child.
Correlation between MTHFR and Autism
I learned about the correlation between MTHFR and autism a few years ago when our family doctor suggested we test our autistic son. The result came back positive and the doctor had us begin treating him right away.
The results have been almost miraculous. It took some time, but after about a year, it became very clear how beneficial this diagnosis was for Nathan.
My son is now calmer, more focused, he can cope better and is less likely to “meltdown” or “rage.” He’s more reasonable and considerate of others.
Finding out my autistic son has MTHFR was not a magic cure, but it has made an incredible difference for him.
My Family’s MTHFR Journey:
I was first introduced to MTHFR by our family physician about 4 years ago. We were struggling with our son’s behavior issues (at the time, he was not yet diagnosed with high functioning autism as he is now) and we were at our whit’s end.
Our doctor suggested we have a simple blood test taken to look for this genetic mutation. She told us many kids like Nathan have this mutation and it can be “treated” with supplements.
We went ahead with the blood test and it came back positive for Nathan. He didn’t just have one copy of the MTHFR SNP, he had TWO copies of A1298c, one of the two most common MTHFR mutations. This is also known as homozygous A1298c.
The fact that he has two copies of this mutation meant Nathan’s body was functioning at 30-40% of what it should be when it comes to the methylation process (read more about that here.)
I learned that MTHFR can be associated with neurological and mood disorders, including ADHD, depression, bipolar, schizophrenia, autism, and more.
Nathan, MTHFR, and Supplements
The doctor had us start Nathan on vitamin supplements to help him right away:
*approximately 50mcg (yes MICROgrams) of methylfolate (we cut up a 400mcg tablet into very small pieces)
*500mcg Methylcobalamin (B-12)
We started Nathan on a very low dose (too high can result in detox symptoms) and gradually worked him up to 400mcg methylfolate and 1000mcg Methylcobalamin, which is what he now takes daily.
Nathan takes these two simple supplements every day (except for the occasional day where he forgets) and he has improved SO much that if he does have a bad day, my first question to him is: “Did you take your vitamins today?” and 9 times out of 10, he’s forgotten!
Last year, he was having a great school year until about February when I began getting phone calls and regular emails from the staff, letting me know he was having “challenges.” It was happening consistently for a good month before I figured out that Nathan hadn’t been taking his vitamins! (He was almost 13 at the time and we were letting him take responsibility for it.)
Needless to say, we implemented a new method to help remind him every day (the 7 day pill organizer that makes it easy for us – and him – to see if he’s taken them) and he improved back to his normal self.
Don’t get me wrong; life isn’t without challenges for Nathan. He does still have some rough days, but they been greatly reduced by supplementing to support the MTHFR mutation.
Does Your Child Have the MTHFR Gene Mutation?
The first step is to get your child tested.
Ask your doctor to order a simple blood test for MTHFR.
Be sure to check with your insurance company; many will not pay for it and you don’t want to get sacked with an unexpected bill later. If your doctor isn’t willing to order the test (most doctors I’ve spoken with have no idea about MTHFR; we were extremely fortunate that our family doctor was informed!), you can order a genetic test online through 23andme.com.
23andMe offers a simple saliva test (what kid wouldn’t love to SPIT into a little tube?!) and will cost you around $200. It’s not cheap, but it’s still less than a costly blood test your insurance won’t pay for! Plus, you’ll also get a lot more genetic information beyond MTHFR that can be very useful in treating your child. Just be sure to order the Ancestry + Health kit.
Once you have the results, you will have the information you need to support your child.
Steps you can take to help your child with MTHFR:
One of your options may be to give your child daily supplements as I described with my son.
Be sure to check with your doctor and if at all possible, find a physician who has experience treating MTHFR patients to help you with this. Every person has different gene combinations and those combinations might change the supplement requirements.
To give you an example: I have 2 copies of MTHFR SNPs myself, but I am different than Nathan. I have one copy of A1298c (Nathan has 2) AND one copy of C677T. For me, taking as much methylfolate as Nathan doses causes a detox reaction no matter how slowly I work up to it. I also take a different version of B-12, called Hydroxocobalamin.
Minimize your child’s exposure to toxins.
If your child has one or more copies of the MTHFR mutation, his or her ability to detox will be reduced.
You can help ease the burden on your child’s body by reducing the number of chemicals your child is exposed to.
This can include everything from common household cleaners and laundry detergent to shampoo and sunscreen.
If you haven’t already, you can begin to gradually switch out household items that contain chemicals with more natural options.
One of the first things we did was a change to a more natural laundry detergent. We now use Mrs Meyers. This was easy enough to do and didn’t overwhelm me.
Reduce processed foods and eat healthily
Try to reduce processed foods (the added folic acid found in many fortified foods, like cereal and bread, can cause issues).
Offer healthy fruits, vegetables, nuts, and other good foods that will help nourish your child and reduce “junk” food.
I know this is often easier said than done, especially if your child prefers to eat the same few foods over and over and over.
Go easy on yourself and your child!
You don’t have to change everything right away. Go easy on yourself and your child!
Make small sustainable changes; it won’t do you any good to get overwhelmed!
Remember that MTHFR treatment takes some time to see good results.
It took us about a year before we began noticing consistent positive changes with our autistic son.
For more reading on how MTHFR affects kids with autism:
- Glutathione Pro: MTHFR and Autism
- Autism Parenting Magazine: Treating Genetic Mutations in Autism
- Mommypotamus: MTHFR Gene Mutations: A Beginner’s Guidehttp://www.mommypotamus.com/mthfr-mutation/
carolyn kelley says
Excellent review, Erika! Not easy to preset this and you have done a great job!! Thanks. Are you seeing Dr Oteri for this?
Thank you, Carolyn! That means a lot coming from you. 🙂
Yes, she was the one who introduced us to MTHFR – it was invaluable information!
Julie Bryant says
This is such an amazing post. My nephew is autistic and posts like this help me understand him much better. Thank you! Please keep posting about it!
Thank you for this!! My daughter is hetero A1298C and I’m always looking for information to help my little one, she’s 2.
Erika, I am very aware of the MTHFR mutation and am a nurse and grandmother of a14 year old high functioning autistic child. i had asked my daughter to get the doctor to order this for my grandson who is struggling in so many areas. am a bit confused as you stated your doctor recommended *50mcg of methylfolate and 500mcg of Methylcobalamin (B-12) which you started at lower doses and brought your son up to 400mcg methylfolate and 100mcg Methylcobalamin which would appear is opposite of doctor recomendations as you only show 50mcg as recommendation for methylfolate and that would also make your B12 dose only a fifth of recommendation. Can you clarify and also tell me where you are finding the lower does of these. I am only finding higher doses available. Thank you
Gina, we use 400mcg methylfolate broken up into smaller doses. It’s hard to be exact but it worked for us.
I left out a 0 with the Methylcobalamin – we did work up to 1,000 mcg.
Megan Holly says
I have Factor V and remember something in my testing about MTHFR. I took lovenox injections while pregnant. My youngest was dx with ASD in October. I have 2 sons and they have never been tested. What type of Dr should they see to be checked if they carry the gene?
I believe you could see a geneticist, but our family doctor ordered the test for us. It’s a regular lab test and it takes a week or two for the results to come back. I’d recommend you check with your insurance company to make sure they cover the cost first so you don’t get stuck with a bill. Sometimes they won’t pay for it.
You can also order yourself through 23andme.com. They do genetic testing and the raw data you’ll receive later will show if your kids have the gene or not.
When you say you gradually increased the dosage on the methylfolate and b12 at what rate did you increase them? How did you know that you reached the effective “sweet spot”?
Thank you in advance!
I can’t remember the exact method I used (it was several years ago) but we gradually increased the dose for a month or two until he seemed to be in a good place. Basically, we started at a very small dose and increased once every week or two.
You stated multiple times that the MTHFR mutation is tested by 23&me but I am looking over my report (health and ancestry) and CANNOT find anything that mentions the mutation in the report. How is it listed, where is it??? It is not under carrier status, genetic risks, traits, nor wellness. I don’t think 23&me is advisable to find the MTHFR mutation, it is not listed!
I’m having my ASD daughter tested by Genesight later today- they will subsidize the cost of your test; if you have Medicaid or Medicare it is free of charge.
Your MTHFR results are in the raw data from 23andme. You can upload the raw data to one of many genetic “decoders” online to find the full results. I used and recommend: http://geneticgenie.org/
Brian Casselman says
Hi, may I ask how old is your son now? We have just figured out our son is within the spectrum, he is almost 3, My wife carries 2 mthfr mutations, we are trying to gather as much information as possible to help him. You article is a great help. We are afraid and trying to stay out of a negative mindset but it is hard. The waiting list to get him diagnosed is long and we are trying to get him help now. We planned to get his genes tested this month. We are looking into Dan doctors as they seem to be on this same path. Any other help or information would be highly appreciated. Thank you so much for sharing this.
Thanks for this testimony.
My 11 year old son was diagnosed with Autism when he was 4. Only a few weeks ago we heard of MTHFR mutations. We found out that he is compound heterozygous for the
variants, C677T and A1298C in the MTHFR gene.
We started him on Enlyte-D, which contains:
L-Methylfolate Magnesium 6mg,
Methylcobalamin (B12) 2mg,
Pyridoxal-r5-Phosphate (B6) 25mg,
Vitamin D3 5000 IU,
Zinc Acorbate 25mg,
It’s been a few weeks, we haven’t seen any results yet. Hopefully in a few weeks.
Thanks for this testimony.
It sparked interest to read research papers like these two:
How was the diagnosis carried out? Did they measure homocystein levels? The pedagogue in our kindergarten suspects that my son (2years) has autism. The physcolog said autism diagnosis starts with age of 3. However, I am molecular biologist. I already had the raw data of his genetic material and i found out that he is compound heterozygous MTHFR like your son. However our pedagogue does not know anyone who is specialized in this. How was it for you?
Are you asking about how autism is diagnosed?
You say you have one copy of each gene. I have the same. Can you please tell me what your daily protocol of supplements include.
Check out MTHFR.net. Lots of helpful info there! I knew I had a single mutation during our struggle to conceive. We tested my son at birth in 2014, and my husband, and learned that my husband had 2 mutations, and my son received one copy from him. As a result, we’ve supplemented my son from birth per our doctors recommendations. And we’re all on supplements. My mom also has 2 copies too. We all have various health issues, that are different from one another, and taking methylated supplements helps a lot. I wish this was common knowledge by now, but most people don’t know anything about it. And no pediatricians that we’ve ever worked with.
My son got the same mutation, was your son very verbal before giving the supplement.
I don’t remember to be honest, sorry! Hopefully this helps your son too.


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Denver health officials are investigating possible tuberculosis exposure to students, faculty and staff at Metropolitan State University in Denver, the agency said Tuesday.
Individuals at Metro State who might have been exposed to tuberculosis have been contacted by Denver Public Health and will be tested. However, the agency said in a news release that there is not an ongoing risk at the school and “it is safe for students and faculty to report to campus as usual for classes and events.”
Health officials have identified about 150 people who likely had “significant exposure to the person with active TB,” said Dr. Michelle Haas, associate director of the agency’s Denver Metro Tuberculosis Program, in an email.
Tuberculosis, also called TB, is caused by bacteria that usually grow in the lungs, although it can affect other body parts, such as the kidney, spine and brain.
Symptoms of the disease include coughing, pain in the chest, fatigue, chills and fever. Not everyone exposed to TB gets the disease, according to the Centers for Disease Control and Prevention.
Rachel Brand, spokeswoman for Denver Public Health, said there is also no concern of possible exposure to students and faculty at the University of Colorado Denver or Community College of Denver. Both schools share the downtown Auraria campus with Metro State.
The investigation at the university comes just a few days after an Aurora middle school was cleared of new tuberculosis cases. All 800 students and staff from Aurora Hills Middle School were tested after several people were infected with tuberculosis.
Haas said it is a “coincidence” that the Metro State tuberculosis investigation is coming on the heels of the Aurora Hills Middle School tests. She said the Denver metro sees about 40 to 55 cases of tuberculosis each year.
There were 84 Coloradans diagnosed with tuberculosis in 2017, up 31 percent from 64 individuals in 2016, according to a report by the state Department of Public Health and Environment.


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Studies show that employees are more likely to be on the job and performing well when they are in optimal health. Benefits of implementing a wellness program include a healthier workforce as well as lower healthcare costs. We are committed to bringing wellness into the workplace with intentions to keep a consistent self-care routine that remains intentional and in the forefront of everyone’s mind.
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If you follow any #fitspo accounts on Instagram, you might have seen personal trainers, bodybuilders and fitness experts talking about counting macros, or even detailing a full list of their macros for the day.
Counting macronutrients, while not a brand new approach, has really taken off over the past three or four years.
"Macronutrients are nutrients that are required in large amounts to provide the energy needed to maintain body functions and carry out the activities of daily life," Holly Louise, known as The Fit Pharmacist, told HuffPost Australia. Louise is a registered pharmacist, certified personal trainer, online coach and expert for Body Science.
"There are three macronutrients -- protein, carbohydrate and fat -- which are molecules contained in different amounts in all food and beverages. Each of these molecules have a corresponding caloric value which give the total caloric value of the food," Louise said.
The caloric value for each of the macronutrients are:
- Protein = 4 calories per 1 gram;
- Carbohydrate = 4 calories per 1 gram;
- Fat = 9 calories per 1 gram;
- Alcohol = 7 calories per 1 gram.
"Once you know how many calories you burn in a day and how many calories you consume in a day, it is easy to calculate your calorie intake in order to achieve your body composition goal, whether it be weight loss or weight gain. By taking it a step further by calculating and tracking your macronutrients specific to your body composition goal, you can target fat loss or muscle gain as opposed to just weight loss or weight gain," Louise said.
Louise uses counting macros as part of the new personalised programs she has formulated for Body Science. The idea behind the programs is to help people stay on track with their health and fitness with information and action points that are easy to follow.
To receive your own program, fill out the online health questionnaire. From your answers you'll be given a free training program and eating plan that is tailored to your needs, based around a 100-point system.
The concept for the 100-point systems came from the 100-point recovery systems that many football teams give to their players. It takes the guess work out of what they need to do for recovery. An example is you get 20 points for eating vegetables and a protein rich meal post-workout, 20 points for sleeping eight hours, and so on.
"Rather than typical calorie counting (for example, eating 1800 calories per day), flexible dieters/macro counters track these macronutrients. Therefore, an example of someone weighing approximately 65kg and eating 1800 calories per day to achieve a specific goal may break this up into 140g of protein, 175g of carbohydrates and 60g of fat," Louise said.
While it sounds time consuming and complicated, counting macros is pretty easy once you get the gist of it.
"Anyone can count macros! The best thing you can do is start by educating yourself. This includes reading about the importance of protein, carbohydrates and fat in the diet and learning about which foods contain which macronutrients. Becoming familiar with nutrition labels on food packaging is also very helpful."
From there, Louise says the easiest way is to take it in stages.
Stage 1: Count Calories
Work out the amount of calories you should be eating each day in order to reach your specific body composition goal. You can get a fitness professional to calculate this for you or do it via an online calculator.
Stage 2: Count Calories And Protein
Continue to reach your calorie goal each day but also add in a protein target to hit as well. This amount will be specific to your body weight and muscle mass. These are the two most important factors in achieving a body composition goal, whether it be fat loss or muscle gain.
Stage 3: Count Protein, Carbohydrates And Fat
Continue tracking your calories and protein and start by adding a fat target too. By default, you will also be tracking your carbohydrates as the remaining macro.
"The easiest way to track your foods is via a food tracking app like MyFitnessPal. Practice makes perfect -- you will be a macro wizard in no time," Louise said.
The upside of counting macros is that you can still eat the foods you love, they are just taken into account so that you don't go overboard.
"Counting macros follows the belief that there are no specific weight loss foods and allows you the flexibility to select foods at your own discretion depending on your preference while remaining accountable to your health and fitness goals. People that give counting macros a bad name are those they try to fit as many 'junk' foods as possible into their macros, with little regard to healthier foods like fruit and vegetables," Louise said.
"However, we must remember that food is more than a just a source of protein, carbohydrate, and fat – it is also our provider of vital micronutrients -- vitamins and minerals -- that support the many physiological functions of our bodies. A healthy body is always going to perform more effectively and efficiently than one which uses processed foods as a fuel source, not to mention that you will be more satisfied by foods that are nutrient dense, such as fruits and vegetables," Louise said.
With that in mind, Louise believes you should aim to get at least 80 percent of your daily calories from whole, micronutrient-dense foods. She also recommends the following guidelines as a minimum:
1. 1-2 serves of fruit per day;
2. 3 serves of vegetables per day;
3. 25g fibre per day.
"People can also get obsessive with trying to reach each target to the gram. This really isn't necessary to achieve results. The best part about counting macros and flexible dieting is that it is just that -- flexible! Consistency will always be the most important factor in achieving your goals," Louise said.
Lastly, keep in mind that the point of keeping track of your macro intake is to be able to be flexible and enjoy a variety of foods. Extreme diets and restrictive eating just doesn't work.
"Experience has also shown that restrictive diets which significantly reduce calories and eliminate food groups are not sustainable and lead to binge eating, cheating, and yo-yo dieting. This in turn creates feelings of guilt, generates self-punishment and negative emotions, resulting in a very unhealthy relationship with food and body image. Life is about balance and enjoyment, therefore, eating a sustainable diet is more likely to lead to success," Louise said.
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Cooking for my family can be tricky when it comes to creating healthy dairy free meals. Having one child anaphylactic to eggs and all egg products and a husband allergic to milk, I have had to be creative preparing meals that are satisfying to an adult palate and still kid friendly. One thing that I have discovered with kids when it comes to diet is that they love variety, and usually will follow their parent or caretaker’s example. Plus almost any ingredient can be substituted or even eliminated to make a healthier alternative meal. Below are some of our family’s favorite vegan dishes. Click photo for recipe.


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Table of Contents
There is growing recognition of the link between diet, inflammation, and disease. Certain dietary patterns were found to either increase (e.g., “Western”) or lower (e.g., Mediterranean) inflammatory biomarkers. Furthermore, the consumption of anti-inflammatory foods was related to a decreased risk of developing chronic health conditions. Despite these findings, there is a paucity of research related to the inflammatory nature of diets in Canada. Objective: The purpose of this study was to investigate the inflammatory nature of diets, as measured by the Dietary Inflammatory Index [DII]. Specifically, we determined the association between DII scores and Healthy Eating Index [HEI] Canada scores, as well as adherence to the Canadian Food Guide recommendations. Methods: This study used data from the Canadian Community Health Survey. Diet, health, and sociodemographic information was collected from participants. T-test and ANOVA analyses were conducted to determine if there were significant differences in mean DII scores between population characteristics. Separate regression analyses were performed to explore the association between DII and HEI Canada scores and adherence to CFG recommendations, respectively. Results: Significantly lower mean DII scores (anti-inflammatory) were reported for men, non-smokers and individuals who met physical activity recommendations. Higher adherence to CFG recommendations was associated with lower DII scores. Conclusion: There were significant differences in DII scores across geographical regions and socio-demographic groups in Canada. Future research should examine the regional differences in DII scores to develop targeted interventions and to further explore the relationship between HEI-C and DII scores.
Keywords: Dietary Inflammatory Index, inflammation, Canada food guide, diet quality


History of Birth Control in Canada
Human beings have practised birth control throughout history. However, in 19th-century Canada, this practice was largely forbidden or taboo. It was only in the 1920s that groups of citizens formed to defend birth control. The information, services and products related to this practice became increasingly accessible after the war. During the 1960s, Canada decriminalized contraception and abortion. In the 1970s, the number of organizations and services promoting access to contraception and family planning began to increase. From then on, birth control became an integral part of the public health approach to sexual health.


Canine Herpesvirus is a disease that affects mostly young puppies. Herpesvirus is forever – once a dog has it, canine herpes will never go away.
How Common is Canine Herpes
It is estimated the canine herpes virus is carried by 70 percent of the canine population. Most dogs enter adulthood having been exposed as puppies, but they carry enough immunity to prevent the symptoms. However, they will shed the virus if they are stressed or if the immune system is compromised.
Canine Herpes Symptoms
Lesions and clinical signs depend on the sex and age of the dog.
Males don’t show symptoms of canine herpes most of the time, but they may have genital lesions – redness and inflamed lymph tissue at the base of the penis. Males may also develop ocular or nasal discharge when stressed, which is a major source of infection to other dogs and to any females that he is breeding.
Canine Herpes in Pregnancy
Females that are naïve to dog Herpes can experience fetal loss, mummies of early fetus, as well as premature birth and loss of puppies at birth or shortly after. The dangerous window for a female is three weeks before and three weeks after whelping. Exposure within this window results in puppy loss. Though a naive female will lose that litter, she will be immune for all future dog Herpes contact, including against litter loss. You want to make sure that she isn’t exposed to any dogs that may be sick during her pregnancy to pick up dog herpes or other viruses that can interfere with pregnancy.
Puppies can be exposed at birth as they pass through the vaginal vault. They will develop signs within three weeks of age, and if they make it past three weeks, they will survive. Clinical signs include anorexia, lethargy, and abdominal pain. Puppy deaths are often classified as “Fading Puppy Syndrome.”
Can You Test a Dog For Herpes Virus
Female dogs can have serum testing, while swabs of ocular and nasal discharge also work. Puppies should be submitted to lab for testing. Kidney hemorrhage is characteristic and the virus can be isolated for the liver, kidneys and lungs.
Canine Herpes Treatment
Once the dog is showing signs of herpes virus, the prognosis is guarded. Most puppies will die. Because therapy is ineffective, preventative measures are the only course of protection.
Canine Herpesvirus is considered temperature sensitive and prefers to replicate at temperatures less than 37°C (98.6°F). Knowing this, we try and control the virus with warm temperatures for the puppies that are not showing signs.
It is also very important to disinfect! The virus is readily inactivated by disinfectants. Try Virkon® or Oxine®. These are penetrating disinfectants that will sterilize the surface as well as get the virus underneath the surface.
Borrowed immunity from a herpes recovered mom can be given to a susceptible litter. A serum injection, 1.5 cc is best, from an immune mom can be given orally during the first 12 hours. You can repeat this serum again day three but you will have to inject at that point. I mix 50/50 with saline for the injection and give it IP (in the tummy.) You can give it via IV, but that is difficult on a puppy. IP is quick and just as effective.
Canine Herpesvirus Vaccine
In Europe they have a herpesvirus vaccine, but in the United States we do not. If importing a vaccinated dog, it’s important to realize that this vaccine does not prevent the virus, it just prevents the puppy loss. Vaccinated dogs still carry the virus and will spread it to your kennel. That is why so many import dogs introduce herpes to our kennel yet the import dog does not lose her puppies. She has that immunity from the vaccine that she passes to the puppies in colostrum.
Canine Herpesvirus Prevention
Once in a kennel, the Canine Herpesvirus is tough or impossible to eliminate. The plan includes exposing all breeding dogs to the virus before breeding, which results in titers high enough to prevent puppy loss. It’s important to give young females a natural immunity to prevent puppy loss in first-time moms. Talk to a veterinarian who has handled Herpes to lay out a game plan that will help prevent puppy loss in the future.
In addition, since herpes can go through the air, disinfect with Animal Facility Disinfectant, Rescue Disinfectant or Virkon. Good hygiene and hand washing after working with each mom and litter is important. The most common way puppies get herpes is when passing through the birth canal. Keep mom and her litter separate from the rest of your kennel for the first three weeks after the puppies are born.
What Happens After a Puppy Survives Canine Herpesvirus?
If exposed to canine herpesvirus, puppies generally do not make it. If puppies are exposed, keep them hydrated with electrolytes such as Breeder’s Edge Puppy Lyte. Since herpes is temperature-sensitive, it can also help to put puppies under a heat lamp or in a portable incubator such as the Puppywarmer® incubator at 101° F for two weeks if they are exposed. This will help to stop the herpesvirus from reproducing. Since that temperature in the incubator is too hot for mom, every two hours bring the puppies to her in order for them to nurse.
If you need help or have more questions on herpes in dogs, call us at 800.786.4751.
Pet Safe Disinfectants: Dog Kennel Cleaner
When choosing dog kennel disinfectant, keep in mind the diseases you are targeting and the animals age. Learn which kennel cleaner to use against Parvo, ringworm and more.
8 Top Pet Health Issues
What are some of the most common dog and cat health problems? From parvovirus to fleas to canine herpesvirus. Check out the eight most common cat and dog health issues Revival Pet Care Pros help customers overcome.
Premature Labor in Dogs
Can a dog go into premature labor? When a pregnant dog goes into premature labor it's important to know what to do. Dr. Greer talks about causes, signs and intervention options.
Why Won’t My Dog Get Pregnant
Dog breeding problems can be challenging. Learn the most common causes of infertility in dogs.
Written by: Donald Bramlage, DVM
Donald Bramlage, Doctor of Veterinary Medicine, practiced veterinary medicine for 30+ years and is known for his work in managing parvovirus. He received his Doctor of Veterinary Medicine from Kansas State University in 1985. He served as Revival’s Director of Veterinary Services from 2011 until his retirement in 2019.


The Sydney Morning Herald recently asked their readers to “picture an all-natural performance drink that is scientifically backed to enhance cognition, increase alertness, reduce brain fog and even improve reaction time and physical performance.” Present Ārepa.
Angus Brown and Zac Robinson, co-founders of Ārepa, have developed an all-natural brain drink that aims to enhance cognition, alertness, and physical performance without relying on caffeine. Brown's experience in the energy drink industry and personal losses motivated them to create a healthier alternative with a felt effect.
After years of research and development, they introduced Ārepa, backed by scientific studies and co-developed with neuroscientist Professor Andrew Scholey. The latest Clinical Study published in the European Journal of Applied Physiology, questions if Ārepa’s Neuroberry blackcurrants can enhance lung function in ozone-dense environments? This exact question sparked the curiosity of scientific researchers at Ārepa. The reason being, many densely populated metropolises are known for varying levels of pollution, which significantly affect athletic performance. When it comes to elite-level competition, even the tiniest differences in performance become of utmost importance.
Although the study primarily examined performance in elite athletes, its findings on reducing the impact of pollution are relevant to all individuals. This holds particularly true for those who regularly exercise in polluted urban environments. This aspect of the study is truly inspiring as it presents potential advantages for everyone, irrespective of their athletic abilities.
Ozone, a potent oxidant gas, is a key component of air pollution found primarily in metropolitan areas. Its presence leads to respiratory tract irritation, compromising lung function and hindering exercise capacity and performance. This discomfort challenges individuals and diminishes their potential to excel.
When athletes train outdoors, they often face increased exposure to air pollutants, making them more vulnerable to the harmful effects. During exercise, a larger volume of air is breathed in, leading to a greater intake of pollutants that penetrate deeper into the lungs. Research investigating the connection between ozone exposure, athletic performance, and lung function reveals that both aerobic capacity and lung function are negatively influenced by poor air quality and ozone exposure. Furthermore, it suggests that continuous exercise exacerbates these effects.
Polyphenols, found in high levels in Ārepa, have shown promising effects in large population studies. These studies have indicated a reduction in respiratory disease, respiratory decline, and respiratory symptoms. Anthocyanins and proanthocyanins, sub-classes of polyphenols, have also been found to alleviate lung inflammation.
Ārepa's Neuroberry blackcurrants (BCs) are meticulously analysed to ensure their remarkable antioxidant activity. They are recognized as one of the leading dietary sources of anthocyanins. Previous research has demonstrated that BC supplementation enhances cycling performance in normal air conditions. However, this groundbreaking study focuses on the effects of polyphenol supplementation on exercise performance in trained athletes exposed to high ozone levels.
With this objective in mind, the study aims to investigate the efficacy of a 7-day polyphenol supplementation regimen on cycling time trial performance and respiratory function. The study will recruit healthy male adults engaging in exercise in an ozone-rich environment.
The study employed a randomised, double-blind, placebo-controlled crossover design. Participants made three visits to the laboratory. All subjects completed the following: (i) an incremental test to exhaustion (V̇O2max) and familiarisation, and (ii) two exercise testing trials in an ozone polluted environment after seven days of either placebo (PL) or blackcurrant supplementation (PB).
During the first laboratory visit, cyclists underwent an incremental ramp test to determine their maximal oxygen consumption (V̇O2max). After a 10-minute rest, they proceeded to a 4 km time trial (TT). The incremental test and familiarisation took place in an environmentally controlled laboratory with ambient air conditions. The ozone trials were conducted in a sealed environmental chamber, with an ozone level set at 0.25 ppm, a value which many cities worldwide experience. Between each supplement regime, there was a 14-day washout period. The study utilised a standardised dose of 4.3 mg/kg anthocyanins in a polyphenol blend supplementation.
Following PB supplementation, there was a significant increase in V̇O2 max during the 4 km TT, as well as higher mean power in the first kilometre compared to PL. The importance of a higher VO₂ max lies in its ability to enhance oxygen consumption and optimise energy generation.
Furthermore, the positive effects of PB supplementation were evident in the reduction of cough severity after 7 days. The researchers also observed lower scores for throat irritation, pain during deep breathing, and shortness of breath, both during the preload protocol and the 4 km TT.
On average, the time to complete the 4 km TT under pollution was 406.43 seconds for the PB group, and 426.20 seconds for the PL group. Although not statistically significant, there is a clear effect. Notably, the PB group was only 1.86% slower when subject to pollution compared to their ambient air performance, whereas the PL group experienced a substantial 6.18% decline.
The significant findings and observable patterns in the data suggest that polyphenols, particularly at the levels found in Ārepa, may mitigate the negative impact on physical performance often associated with polluted environments. This facilitates more beneficial training and greater performance outcomes, even in large cities coping with increased ozone concentrations.


Gov. Eric Holcomb says it's an example of why states are better prepared to meet the health care needs of residents.
About 66,000 Hoosiers signed up for healthcare coverage through the federal marketplace for the first time.
Overall, enrollment increased in 2016, but enrollment in Indiana is down by a little over 20,000.
The number of people enrolled for health insurance from the public exchange is up this year. About 175,000 of those are Hoosiers.
The initial deadline for Jan. 1 coverage was Dec. 15.
Open enrollment started Nov. 1 and runs until Jan. 31, 2016.
Nearly 219,000 Hoosiers signed up for 2015 healthcare coverage.
Open enrollment for health insurance through the federal marketplace ends Sunday.
Health care navigators in Indiana say they have had a relatively good experience signing people up for insurance.
Open enrollment is beginning for the federal health exchange. How parents are making ends meet with the rising costs of childcare.


Author + information
- Benjamin J.W. Chow, MD* (, )
- Paul J. Galiwango, MD,
- Angeline Law, MD and
- Nisha D'Mello, MD
- ↵*University of Ottawa Heart Institute, Division of Cardiology, 40 Ruskin Street, Room 1220A, Ottawa, Ontario K1Y 4W7, Canada
We thank Dr. Symanski for his interest in our article describing a rare coronary anomaly (1). We are grateful that he brings to our attention the post-mortem results of Pete Maravich's heart (2). We agree that this anomaly, unbeknownst to us, has been previously described.
It was interesting to read the post-mortem examination that described a dilated heart weighing 650 g and having a left ventricular wall thickness of 15 mm. Equally interesting were the findings of myocardial fibrosis consistent with chronic ischemia. Dr. Symanski questions whether a similar pathophysiology may be contributing to our patient's chest pain.
At follow-up, our patient's atypical chest pain had completely resolved. On further review, our patient also had normal left ventricular volumes, mass, and ejection fraction. Cocker et al. (3) recently described the finding of myocardial fibrosis in elite athletes using magnetic resonance imaging. We wonder whether Pete Maravich's history as an elite athlete in combination with this rare coronary anomaly partially explains his post-mortem findings.
- American College of Cardiology Foundation


Erectile Dysfunction (ED) is a common problem that numerous men deal with. It can be caused by a range of concerns, including nervous system issues, arterial hardening, and anxiety.
The most common treatment for this condition is to use a male improvement drug, such as Viagra. Nevertheless, there are several other treatment alternatives, such as acupuncture, which have actually been understood to be extremely reliable.
Erectile dysfunction, or ED, is a typical issue that impacts countless men. It can be a sign of other health concerns, such as heart disease, or it can be simply an outcome of regular aging. In either case, treatment is offered to assist minimize the issue.
An excellent primary step is to check out a medical care doctor. They can evaluate for cardiovascular risk factors, such as smoking cigarettes and hypertension. If erectile dysfunction is discovered, treatment will focus on enhancing circulatory health.
Men needs to also speak with their urologist. They can recommend medication to improve blood flow to the penis. Alternatively, they might advise specific screening. Some men will be prospects for surgical treatment.
The most typical reason for erectile dysfunction is vascular disease. This is when the arteries that provide blood to the penis ended up being blocked, resulting in reduced blood flow. Other causes consist of diabetes, obesity, and hypertension.
Particular medications and physical elements can also lower the quantity of blood flowing to the penis. Exercise is a terrific method to increase blood circulation. Tension can also contribute in decreasing blood flow.
Other issues associated with erections can be caused by atherosclerosis, which is the accumulation of plaque. Plaque is a cellular waste that contains cholesterol and fibrin, which can block the arteries. Signs consist of increased high blood pressure and the advancement of atherosclerosis.
While there are numerous factors to consider, erectile dysfunction is an early warning sign of more serious health issue Treatment focuses on improving a male’s circulatory system, along with his sex function.
Taking a detailed method to vascular health will be a lifesaver for ED clients. Identifying and treating the problem prior to it worsens can reduce the possibility of cardiac arrest, stroke, and other vascular events.
Nervous System Problems
There are many neurological conditions that can cause erectile dysfunction. These issues might be set off by injury or illness. Many of these conditions are persistent. As a result, a guy’s sexual function might be affected for an extended period.
Neurological sexual dysfunction can have a terrible result on a man’s quality of life. Some reasons for impotence are reasonably well comprehended, while others stay more mysterious. Thankfully, advances in molecular biology have helped researchers much better comprehend the pathophysiology of erectile dysfunction.
Neurogenic sexual dysfunction can be brought on by conditions of the central or peripheral nervous system. It is essential to comprehend the differences between these conditions. Regardless of the cause, a male with neurogenic erectile dysfunction is at a higher danger of using illegal drugs and experiencing a lower self-esteem.
Whether or not a guy has erectile dysfunction, he can take actions to improve his sexual health. He can ask his doctor about a possible sexual issue, which can help discover a major health condition prior to it reaches a sophisticated phase.
Erectile dysfunction can be a sign of a number of medical conditions, consisting of spine injury, diabetes mellitus, numerous sclerosis, and Parkinson’s illness. Men with these conditions may experience diminished feeling, increased fatigue, and problems attaining orgasms.
Men with these conditions can undergo nerve-sparing procedures to restore erectile function. The procedure usually takes a few months to a year.
Erectile dysfunction can likewise be a sign of a more severe condition, such as cancer. Treatments can consist of chemotherapy or radiation. Medical professionals can diagnose a patient’s condition by taking a look at a man’s sexual history. This history can discriminate between an erection and a lack of erection.
Arterial Hardening of the Arteries
Arterial hardening of the arteries triggers erectile dysfunction, a condition where men experience difficulty getting or preserving an erection. This is especially common in older men, as well as those with diabetes or high cholesterol. It is a risk aspect for cardiovascular disease, stroke and cardiovascular disease.
The majority of erectile dysfunction cases are brought on by blocked arteries. Some of the most obvious signs of artery obstruction consist of a reduced erection time, reduced rigidness throughout erection, a slower rate of erection development and a lack of spontaneity during sexual stimulation.
Erectile dysfunction is a warning sign that you have peripheral artery disease or atherosclerosis. If left unattended, PAD can cause leg discomfort, non-healing sores, and amputation. A medical diagnosis of ED can also anticipate the onset of coronary artery disease.
Men with ED who have a family history of cardiovascular diseases are at higher risk for cardiovascular issues. They ought to have a screening test for PAD and coronary artery disease. An ankle-brachial index test can be carried out to figure out whether a person has peripheral artery illness.
Roughly 50 percent of men between the ages of 40 and 70 will experience erectile dysfunction. In fact, erectile dysfunction is one of the most widespread conditions in this age group.
One factor that erectile dysfunction is an indication of vascular illness is that a buildup of cholesterol in the arteries makes it harder for blood to flow through. High cholesterol levels can also increase the danger of a cardiac arrest. Whether or not you have a family history of cardiovascular disease, it is an excellent idea to have your cholesterol checked routinely.
A recent research study carried out in Australia found that ED was more typical in men with a cardiovascular disease than in those without. Scientist concluded that erectile dysfunction is a precursor of CVD.
Diabetes and erectile dysfunction are two conditions that can impact men of any ages. Erectile dysfunction is a condition in which the man can not achieve and preserve an erection for sex. It is a typical problem of diabetes.
Erectile dysfunction can be triggered by numerous various aspects. A few of these elements consist of mental concerns, medications, and persistent diseases. Others might be a result of hypertension or cardiovascular disease. However, erectile dysfunction related to diabetes is typically treated with an integrated method to health management.
High blood glucose levels can damage the arteries and nerves of the penis. These problems can cause a loss of venous flow, which prevents the corpora cavernosa from expanding.
Men with diabetes also tend to have actually a decreased sex drive. In fact, a recent research study found that males with type 2 diabetes had actually an increased risk of erectile dysfunction. A decrease in the quantity of nitric oxide produced by the body can also be a contributing aspect to erectile dysfunction.
In addition to the above-mentioned elements, diabetes and erectile dysfunction can also be connected to a number of other conditions. For instance, hypertension and heart disease can increase the threats of ED.
Other possible factors that contribute to erectile dysfunction include tension and stress and anxiety. Workout and a healthy diet plan have been revealed to improve erectile function. If you have an issue with erectile dysfunction, consult your doctor to discover if you have any other health conditions.
There are lots of treatments for erectile dysfunction. These include medication and diet. Increasing testosterone levels can likewise be practical.
Getting enough sleep, staying calm, and preventing stress are also advised. Stress can cause an erection to intensify, so taking some time for relaxation and mental rest is very important.
When an individual experiences erectile dysfunction, they often have feelings of humiliation and even frustration. This is because of a mix of physical and psychological elements. If you are suffering from erectile dysfunction, it is essential to seek help as soon as possible.
Many men with ED experience some level of depressive affect. In fact, a recent research study released in the Journal of Sexual Medicine showed a link between depression and erectile dysfunction.
There are a range of ways to deal with depression, consisting of medication, psychotherapy, and natural solutions. These approaches can help you return on your feet.
Depression and erectile dysfunction are related in the sense that an individual with depression might not have a lot of energy. Not having enough energy is a typical reason for bad erections.
Some medications can likewise have an unfavorable effect on sexual function. It’s essential to discuss all of your alternatives with your doctor prior to beginning any brand-new medication.
A detailed technique to treatment can assist you attain optimum erections and overall health and wellbeing. Your GP will be able to suggest treatments.
While there is no one test to identify anxiety, there are some patterns to search for. An erection is a result of the brain chemical dopamine being launched. The greater the levels of serotonin available, the less dopamine is required to produce an erection.
Another interesting sign to look for is hypogonadism. The hormonal agent testosterone plays a significant role in sexual efficiency. Patients with hypogonadism are most likely to have an erectile disorder.
In general, erectile dysfunction is not brought on by age. Nevertheless, the symptoms of depression may be related to age.
In addition, there are a variety of medical conditions that can cause erectile dysfunction. Seizure disorders, neurodegenerative illness, and posttraumatic stress disorder are all connected with increased rates of depression.


Painting the Current Picture
NADCP’s newest report detailing the expansion of drug courts and other treatment court models, including DWI courts and veterans treatment courts, as well as the latest research.
Publisher: National Drug Court Institute
Published: 2016 (88 pages)
For a downloadable PDF version, see “You may also like…” below.


High Priest Breastplate Hoshen Stones 12 Tribes of Israel Wall Decor
Reuben strengthens life power and energy, Judah is able to protect against the negative energy and helps to reach luck, Dan gives joy and strength and attracts wealth, Asher calms down and helps to concentrate, Simeon struggles fears and gives harmony and Issachar gives health and soul strength. Also the Hoshen is decorated Naphtali, which is able to heal the sick and get self-confidence, Joseph strengthens memory, Levi is able to struggle the stress and heals various disease, Zebulun protects against the evil eye and negative energy, Gad keeps harmony and Benjamin helps to get physical strength.
Size: 19.5 x 14.5 (7.6 x 5.7")
Material: Wood & Stones
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Mentos Chewy Mints Strawberry Mix
Discover the exciting taste of Mentos Strawberry Mix—sweet, original & sour strawberry flavours.
Serving Size 1 piece (2.7g)
Amounts per serving % Daily values* Calories 10 Fat 0 g Saturated Fat 0 g Trans Fat 0 g Sodium 0 mg Carbohydrate 3 g Sugars 2 g Sugar Alcohols 0 g Protein 0 g
*Percent Daily Values are based on a 2,000 calorie diet
Sugar, Wheat Glucose Syrup, Strawberry Juice from Concentrate (2%), Hydrogenated Coconut Oil, Citric Acid, Corn Starch, Artificial Flavour, Maltodextrin, Sucrose Esters of Fatty Acid, Gellan Gum, Carnauba Wax, Cellulose Gum, Gum Arabic, Colour, Beeswax. Allergen: Wheat.
- Vegetarian: Yes
- Gluten Free: Yes
- Emulsifiers: Vegetable-based
- Nut allergens: None


Nestin antibody | Rat-401 (4D4)
Mouse anti Rat Nestin
- Product Type
- Monoclonal Antibody
- Rat-401 (4D4)
|Mouse anti Rat Nestin antibody, clone Rat-401 recognizes rat nestin, a large intermediate filament protein transiently expressed in embryonic glian cells (Hockfield and McKay 1985). It is predominately expressed in stem cells of the developing nervous system. Terminal differentiation is associated with a loss of nestin expression. Nestin expression has also been noted in other embryonic tissues, also in most Glioblastoma multiformes and many melanomas.|
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Human Mouse
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- TRIS buffered glycine.
- Preservative Stabilisers
- 0.05% Sodium Azide (NaN3)
- Nestin purified from embryonic rat spinal cord.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells of the NS1 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1/40||1/400|
|Immunohistology - Paraffin||1/40||1/400|
- We recommend perfusing tissues with 4% paraformaldehyde at pH 7.4 for light microscopy or with either 4% paraformaldehyde at pH 10.0 or 4% paraformaldehyde with 0.1% glutaraldehyde at pH 7.4 for EM. For Immunocytochemistry we recommend using cells fixed in 4% paraformaldehyde buffered with 50 mM sodium borate at pH 9.5.
- Western Blotting
- Mouse anti Rat Nestin antibody, clone Rat-401 reacts with a band at 200-220 kDa in reducing gels of newborn rat or mouse cell extracts. For western blotting it is recommended that samples should be boiled in 4 volumes of 125 mM Tris, pH 6.8, 10% 2-mercaptoethanol, 10% glycerol and 4.6% SDS. Membranes should be blocked with milk or BSA. 5% PAGE gels are suggested.
Hockfield, S. & McKay, R.D. (1985) Identification of major cell classes in the developing mammalian nervous system.
J Neurosci. 5 (12): 3310-28.
References for Nestin antibody
Aleksandrova, M.A. et al. (2001) Transplantation of Cultured Human Neural Progenitor Cells into Rat Brain: Migration and Differentiation
Bull Exp Biol Med. 132: 1000-3.
Poltavtseva, R.A. et al. (2001) In vitro development of neural progenitor cells from human embryos.
Bull Exp Biol Med. 132: 861-3.
Bertelli, E. et al. (2002) Nestin expression in rat adrenal gland.
Histochem Cell Biol. 117: 371-7.
Zhang, H. et al. (2003) VEGF is a chemoattractant for FGF-2-stimulated neural progenitors.
J Cell Biol. 163: 1375-84.
Mori, T. et al. (2005) Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the life span of bone marrow stromal cells from an elderly donor without affecting their neurogenic potential.
Mol Cell Biol. 25: 5183-95.
Choi, J.S. et al. (2007) Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 following acute spinal cord contusion in rats.
J Histochem Cytochem. 55: 821-30.
Choi, J.S. et al. (2009) Enhanced expression of SOCS-2 in the rat hippocampus after transient forebrain ischemia.
J Neurotrauma. 26: 2097-106.
Choi, J.S. et al. (2009) Transient expression of Bis protein in midline radial glia in developing rat brainstem and spinal cord.
Cell Tissue Res. 337: 27-36.
View The Latest Product References
Barreira, A.L. et al. (2009) Bone marrow mononuclear cells attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells after unilateral ureteral obstruction.
Cell Physiol Biochem. 24: 585-94.
Choi, J.S. et al. (2010) Expression of vascular endothelial growth factor receptor-3 mRNA in the rat developing forebrain and retina.
J Comp Neurol. 518: 1064-81.
Shin, Y.J. et al. (2010) Enhanced expression of vascular endothelial growth factor receptor-3 in the subventricular zone of stroke-lesioned rats.
Neurosci Lett. 469: 194-8.
Arnold, T.D. et al. (2012) Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin αVβ8-Mediated Activation of Transforming Growth Factor-β.
J Neurosci. 32: 1197-206.
Shin, Y.J. et al. (2013) Induction of vascular endothelial growth factor receptor-3 expression in perivascular cells of the ischemic core following focal cerebral ischemia in rats.
Acta Histochem. 115 (2): 170-7.
Araujo, R.M. et al. (2016) Mesenchymal stem cells promote augmented response of endogenous neural stem cells in spinal cord injury of rats
Semina: Ciências Agrárias. 37 (3): 1355.
Shin, Y.J. et al. (2016) Increased expression of suppressor of cytokine signaling 2 in the subventricular zone after transient focal cerebral ischemia in adult rats.
Brain Res. 1648 (Pt A): 163-71.
- Entrez Gene
- GO Terms
- GO:0005882 intermediate filament
- GO:0005198 structural molecule activity
- GO:0007420 brain development
- GO:0042493 response to drug
- GO:0010212 response to ionizing radiation
- GO:0019215 intermediate filament binding
- GO:0030182 neuron differentiation
- GO:0030844 positive regulation of intermediate filament depolymerization
- GO:0031076 embryonic camera-type eye development
- View More GO Terms
- GO:0031667 response to nutrient levels
- GO:0031730 CCR5 chemokine receptor binding
- GO:0043066 negative regulation of apoptosis
- GO:2000179 positive regulation of neural precursor cell proliferation
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