1 Y O U R G U I D E T O Physical Activity and Your Heart U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute
3 YOUR GUIDE TO Physical Activity and Your Heart U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute NIH Publication No June 2006
4 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute
5 Contents On the Move Physical Activity and Your Health Physical Activity: The Heart Connection Heart Disease Risk Factors You Have Control Eight Tips for Heart Health Physical Activity: The Calorie Connection The Benefits Keep Coming Go for the Burn! Great Moves Types of Physical Activity Working Together for Health A Complete Activity Program Three Moves for Health Intensity Levels Choosing Your Moves Getting in Motion Exploding the Myths Taking Precautions Choosing the Right Activity Smart Moves Tracking Your Target Heart Rate Finding Your Target Heart Rate Zone A Sample Walking Program A Sample Jogging Program Playing It Safe Avoid Injury Eat Right Check the Weather Report Taking Too Much Heat Seek Company Know the Signs of a Heart Problem Get Back in the Swing Contents
6 iv Staying Active Motivation Makers Creating Opportunities Family Fitness Measuring Your Mileage Moving Toward Health To Learn More
7 On the Move Chances are, you already know that physical activity is good for you. Sure, you may say. When I get out and move around, I know it helps me to feel and look better. But you may not realize just how important regular physical activity is to your health. According to the U.S. Surgeon General s Report on Physical Activity and Health, inactive people are nearly twice as likely to develop heart disease as those who are more active. This is true even if you have no other conditions or habits that increase your risk for heart disease. Lack of physical activity also leads to more visits to the doctor, more hospitalizations, and more use of medicines for a variety of illnesses. The good news is that physical activity can protect your heart in a number of important ways. Moreover, to get benefits, you don t have to run a marathon. Regular activity something as simple as a brisk, 30-minute walk each day can help you to reduce your risk of heart disease. This booklet will help you to understand the impact of physical activity on your heart, as well as the power of regular activity to help keep you healthy overall. It will also offer plenty of ideas on starting a physical activity program that will be both healthful and enjoyable. Just as important, you ll get tips for keeping up with the activity or activities you choose, since staying active over time is important to long-term health. So use this booklet often for information, ideas, and to keep you motivated. When to start getting fit? There s no time like today. 1On the Move
8 2 ALAN AND LILA LETOW Exercise and taking good care of ourselves are important parts of our life plan. Lila and I exercise regularly and look to not only cardiovascular and strength building exercises, but also to improving our muscle flexibility and range of motion. Hopefully, this should keep us fit for the years ahead.
9 Physical Activity and Your Health If you currently get regular physical activity, congratulations! But if you re not yet getting all the activity you need, you have lots of company. According to the Centers for Disease Control and Prevention (CDC), 60 percent of Americans are not meeting the recommended levels of physical activity. Fully 16 percent of Americans are not active at all. Overall, women tend to be less active than men, and older people are less likely to get regular physical activity than younger individuals. What does it mean to get regular physical activity? To reduce the risk of heart disease, adults need only do about 30 minutes of moderate activity on most, and preferably all, days of the week. This level of activity can also lower your chances of having a stroke, colon cancer, high blood pressure, diabetes, and other medical problems. If you re also trying to manage your weight and prevent gradual, unhealthy weight gain, try to get 60 minutes of moderate- to vigorous-intensity activity on most days of the week. At the same time, watch your calories. Take in only enough calories to maintain your weight. Those who are trying to keep weight off should aim a bit higher: Try to get minutes of moderate-intensity activity daily, without taking in extra calories. Later in the book, you ll find out more about the types of activities that you can easily fit into your routine, as well as ways to break up your activity time into manageable segments. If you re not as active as you might be, take a moment to consider why. Maybe you re just in the habit of traveling by car or bus, even when you re not going far. In your free time, perhaps it s tempting to sit down in front of the TV or computer rather than do something more vigorous. It s easy to get busy or tired and decide that it s just simpler to put off that brisk walk or bike ride. But when you think about the serious problems that physical inactivity can create for your health and the enormous rewards of getting regular activity 3Physical Activity and Your Health
10 4 you may want to reconsider. Let s start with the ways that physical activity affects your heart. Physical Activity: The Heart Connection It s worth repeating: Physical inactivity greatly increases your risk of developing heart disease. Heart disease occurs when the arteries that supply blood to the heart muscle become hardened and narrowed, due to a buildup of plaque on the arteries inner walls. Plaque is the accumulation of fat, cholesterol, and other substances. As plaque continues to build up in the arteries, blood flow to the heart is reduced. Heart disease can lead to a heart attack. A heart attack happens when a cholesterol-rich plaque bursts and releases its contents into the bloodstream. This causes a blood clot to form over the plaque, totally blocking blood flow through the artery and preventing vital oxygen and nutrients from getting to the heart. A heart attack can cause permanent damage to the heart muscle. Your Guide to Physical Activity and Your Heart Some people aren t too concerned about heart disease because they think it can be cured with surgery. This is a myth. Heart disease is a lifelong condition. It s true that certain procedures can help blood and oxygen flow more easily to the heart. But the arteries remain damaged, which means you are still more likely to have a heart attack. What s more, the condition of your blood vessels will steadily worsen unless you make changes in your daily habits and control other factors that increase risk.
11 Heart disease is a serious disease and too often, a fatal one. It is the number one killer of Americans, with 500,000 people in the United States dying of heart disease each year. Many others with heart problems become permanently disabled. That s why it s so vital to take action to prevent this disease. Getting regular physical activity should be part of everyone s heart disease prevention program. Heart Disease Risk Factors Risk factors are conditions or habits that make a person more likely to develop a disease. They can also increase the chances that an existing disease will get worse. Certain risk factors for heart disease, such as getting older or having a family history of early heart disease, can t be changed. But physical inactivity is a major risk factor for heart disease that you have control over. You can make a decision to get regular physical activity, and this booklet can help you create a workable, enjoyable program that will help you protect your heart. Other major risk factors for heart disease that you can change are smoking, high blood pressure, high blood cholesterol, overweight, and diabetes. (See the box, You Have Control, on page 6.) Every risk factor counts. Research shows that each individual risk factor greatly increases the chances of developing heart disease and having a heart attack. A damaged heart can damage your life, by interfering with enjoyable activities and even keeping you from doing simple things, such as taking a walk or climbing steps. But it s important to know that you have a lot of power to protect your heart health. (See the box, Eight Tips for Heart Health, on page 7.) Getting regular physical activity is an especially important part of your healthy heart program, because physical activity both directly reduces your heart disease risk and reduces your chances of developing other risk factors for heart disease. For example, regular physical activity may reduce LDL (bad) cholesterol, increase HDL (good) cholesterol, and lower high blood pressure. It can also protect your heart by helping to prevent and control diabetes. Finally, physical activity can help you to lose excess weight or stay at your desirable weight, which will also help to lower your risk of 5Physical Activity and Your Health
12 6Your Guide to Physical Activity and Your Heart You Have Control Physical inactivity is one of several major risk factors for heart disease that you can do something about. The others are: Smoking. People who smoke are up to six times more likely to suffer a heart attack than nonsmokers, and the risk increases with the number of cigarettes smoked each day. Quitting will greatly reduce your risk. Check with local community groups for free or low-cost programs designed to help people stop smoking. High Blood Pressure. Also known as hypertension, high blood pressure increases your risk of heart disease, stroke, kidney disease, and congestive heart failure. Your health care provider can check your blood pressure by means of a simple test using an inflatable arm cuff. Blood pressure often can be entirely controlled by getting regular physical activity, losing excess weight, cutting down on alcohol, and changing eating habits, such as using less salt and other forms of sodium. For some people, medication is also needed. High Blood Cholesterol. High blood cholesterol can lead to the buildup of plaque in your arteries, which raises the risk of a heart attack. Starting at age 20, everyone should have their cholesterol levels checked by means of a blood test called a lipoprotein profile. You can lower high blood cholesterol by getting regular physical activity, eating less saturated fat and trans fat, and managing your weight. In some cases, medication is also needed. Overweight. If you are overweight or obese, you are more likely to develop heart disease even if you have no other risk factors. Ask your doctor to help you determine whether you need to lose weight for your health. The good news: Losing just 5 10 percent of your current weight will help to lower your risk of heart disease and many other medical disorders. Diabetes greatly increases your risk for heart disease, stroke, and other serious diseases. Ask your doctor whether you should be tested for it. Many people at high risk for diabetes can prevent or delay the disease by reducing calories as part of a healthy eating plan, and by becoming more physically active. If you already have diabetes, work closely with your doctor to manage it.
13 Eight Tips for Heart Health Become and stay physically active. Balance your calorie intake with the calories you burn in physical activity. Lose weight if you re overweight. If you smoke, stop. Avoid other people s smoke if you can. Control high blood pressure. Control high blood cholesterol. Control diabetes. Choose foods low in saturated fat, trans fat, cholesterol, sugar, and salt. Enjoy more fruits, vegetables, and whole grains. heart disease. Physical Activity: The Calorie Connection One way that regular physical activity protects against heart disease is by burning extra calories, which helps you to lose excess weight or stay at your desirable weight. To understand how physical activity affects calories, it is helpful to consider the concept of energy balance. Energy balance is the amount of calories you take in relative to the amount of calories you burn. Per week, you need to burn off about 3,500 more calories than you take in to lose 1 pound. If you need to lose weight for your health, regular physical activity can help you through one of two approaches. First, you can choose to eat your usual amount of calories, but be more active. For example, a 200-pound person who keeps on eating the same amount of calories, but begins to walk briskly each day for 1 1 /2 miles, will lose about 14 pounds in 1 year. Staying active will also help to keep the weight off. Second, you can eat fewer calories and be more active. This is the best way to lose weight, since you re more likely to be successful by combining a healthful, lower-calorie diet with physical activity. For example, a 200-pound person who consumes 250 fewer calories per day, and begins to walk briskly each day for 1 1 /2 miles, will lose about 40 pounds in 1 year. Most of the energy you burn each day about three quarters of it 7Physical Activity and Your Health
14 8Your Guide to Physical Activity and Your Heart goes to activities that your body automatically engages in for survival, such as breathing, sleeping, and digesting food. The part of your energy output that you control is daily physical activity. Any activity you take part in beyond your body s automatic activities will burn extra calories. Even seated activities, such as using the computer or watching TV, will burn calories but only a very small number. That s why it s important to make time each day for moderate-tovigorous physical activity. The Benefits Keep Coming It is hard to imagine a single practice with more health benefits than regular physical activity. In addition to protecting your heart in numerous ways, staying active: May help to prevent cancers of the breast, uterus, and colon. Strengthens your lungs and helps them to work more efficiently. Tones and strengthens your muscles. Builds stamina. Keeps your joints in good condition. Improves balance. May slow bone loss. Regular physical activity can also boost the way you feel. It may: Give you more energy. Help you to relax and cope better with stress. Build confidence. Allow you to fall asleep more quickly and sleep more soundly. Help you to beat the blues. Provide an enjoyable way to share time with friends or family.
15 Go for the Burn! Some physical activities burn more calories than others. Below are the average number of calories a 154-pound person will burn, per hour, for a variety of activities. (A lighter person will burn fewer calories; a heavier person will burn more.) As you can see, vigorous-intensity activities burn more calories than moderate-intensity activities. Moderate Physical Activity Hiking 370 Light gardening/yard work 330 Dancing 330 Golf (walking and carrying clubs) 330 Bicycling (less than 10 mph) 290 Walking (3.5 mph) 280 Weight lifting (light workout) 220 Stretching 180 Vigorous Physical Activity Calories Burned per Hour Calories Burned per Hour Running/jogging 590 Bicycling (more than 10 mph) 590 Swimming (slow freestyle laps) 510 Aerobics 480 Walking (4.5 mph) 460 Heavy yard work (chopping wood, 440 for example) Weight lifting (vigorous workout) 440 Basketball (vigorous) 440 Source: Adapted from the 2005 Dietary Guidelines Advisory Committee Report 9Physical Activity and Your Health
16 10 LILY KRAMER I think exercise is extremely important. Whenever I feel stressed out, I go to the gym and work out. I come out of there feeling much better. Your Guide to Physical Activity and Your Heart
17 11 Great Moves Given the numerous benefits of regular physical activity, you may be ready to get in motion! But first, it s important to know how activities differ from one another and how each form of movement uniquely contributes to your health. Three types of activity are important for a complete physical activity program: aerobic activity, resistance training, and flexibility exercises. Let s take a brief look at each one. Types of Physical Activity Aerobic activity is any physical activity that uses large muscle groups and causes your body to use more oxygen than it would while resting. This booklet focuses mainly on aerobic activity because it is the type of movement that most benefits the heart. Examples of aerobic activity are brisk walking, jogging, and bicycling. Resistance training also called strength training can firm, strengthen, and tone your muscles, as well as improve bone strength, balance, and coordination. Examples of strength moves are pushups, lunges, and bicep curls using dumbbells. Flexibility exercises stretch and lengthen your muscles. These activities help to improve joint flexibility and keep muscles limber, thereby preventing injury. An example of a stretching move is sitting cross-legged on the floor and gently pushing down on the tops of your legs to stretch the inner thigh muscles. Working Together for Health While aerobic activities benefit the heart most, all three types of movement are vital components of a physical activity program. They also work together in important ways. For example, resistance exercises can help you achieve the muscle strength, balance, and Great Moves
18 12 coordination to do your aerobic activities more successfully. Meanwhile, flexibility training will help you to move your muscles and joints more easily and prevent injury as you engage in aerobic activities. Many activities that promote flexibility and strength are also relaxing and fun. (See the box, Three Moves for Health, on page 13.) Below is a sample schedule for a well-rounded activity program. A Complete Activity Program A Sample Weekly Schedule Sunday Aerobic Stretch Monday Aerobic Strength Stretch Tuesday Aerobic Stretch Wednesday Aerobic Strength Stretch Thursday Aerobic Stretch Friday Aerobic Strength Stretch Your Guide to Physical Activity and Your Heart Saturday Aerobic Stretch
19 13 Three Moves for Health While not usually aerobic, the activities below offer numerous health benefits and are enjoyable ways to get and stay in shape. All are offered at many YMCAs, community or recreation centers, and gyms. Yoga is a system of physical postures, stretching, and breathing techniques that can improve flexibility, balance, muscle strength, and relaxation. Many styles are available, ranging from slow and gentle to athletic and vigorous. A recent study found that regular yoga practice may help to minimize weight gain in middle age. Tai chi is an ancient Chinese practice based on shifting body weight through a series of slow movements that flow rhythmically together into one graceful gesture. This gentle, calming practice can help to improve flexibility and balance, and it gradually builds muscle strength. Pilates is a body conditioning routine that seeks to strengthen the body s core (torso), usually through a series of mat exercises. Another Pilates method uses special exercise machines, available at some health clubs. The practice can strengthen and tone muscles as well as increase flexibility. Great Moves
20 14 Intensity Levels Generally, the more vigorously you engage in an activity, and the more time you spend doing it, the more health benefits you will receive. The vigorous activities listed in the left column of the box, Choosing Your Moves, page 15, are especially helpful for conditioning your heart and lungs, and these activities also burn more calories than those that are less vigorous. However, moderate-intensity activities can also be excellent fitness choices. When done briskly for 30 minutes or longer on most days of the week, the moderate-intensity activities listed in the column on the right side of the box can help to condition your heart and lungs and reduce your risk of heart disease. Your Guide to Physical Activity and Your Heart
21 15 Choosing Your Moves Vigorous activity Aerobic dancing Basketball Bicycling (more than 10 mph) Cross-country skiing Hiking (uphill) Ice hockey/field hockey Jogging/running (at least 5 mph) Jumping rope Soccer Stair climbing Tennis (singles) Walking briskly (4.5 mph) Weight lifting (vigorous effort) Yard work (heavy) Moderate activity Bicycling (less than 10 mph) Downhill skiing Dancing Gardening Golf (on foot) Hiking (flat ground) Horseback riding Roller skating/ice skating Softball Swimming Tennis (doubles) Walking moderately (3.5 mph) Weight lifting (moderate effort) Yard work (light) Great Moves
22 16 RICARDO ELEY My doctor noticed my blood pressure was a little high. At that time, I was not thinking about exercising every day like I do now. Since then, I ve lost weight, and my body is in good shape now. I really watch what I eat, and I work out 5 to 7 days a week.
23 17 Getting in Motion Ready to get moving? If so, getting health benefits from regular activity may be easier than you think. As discussed at the start of this book, about 30 minutes of moderate-intensity physical activity on most and preferably all days of the week will help you to reduce the risk of heart disease. If you can gradually work up to more time being active, you ll get even more benefits. Brisk walking is a simple, enjoyable way to help keep your heart healthy. One study showed that regular, brisk walking reduced the risk of heart attack by the same amount as more vigorous exercise, such as jogging. Keep in mind, too, that you can break up any activity into shorter periods of at least 10 minutes each. For example, if you want to total 30 minutes of activity per day, you could spend 10 minutes walking on your lunch break, another 10 minutes raking leaves in the backyard, and another 10 minutes lifting weights. See pages for sample walking and jogging programs. Exploding the Myths Even when you know physical activity is good for you, it s easy to keep dragging your feet literally. We all have reasons to stay inactive, but sometimes those reasons are based more on myth than reality. Here are some of the most common myths about physical activity and ways to replace them with a more realistic, can-do spirit. Myth 1: Physical activity takes too much time. Physical activity does take some time, but there are ways to make it manageable. If you don t have 30 minutes in your daily schedule for an activity break, try to find three 10-minute periods. If you re aiming for 60 minutes daily a good goal if you re trying to avoid weight gain perhaps you can carve out some fitness time early in the day, before your schedule gets too busy. Another idea is to combine physical activity with a task that s already part of your daily routine, such as walking the dog or doing yard chores. Getting in Motion
24 18 Myth 2: Getting in shape makes you tired. Once you begin regular physical activity, you re likely to have even more energy than before. As you progress, daily tasks will seem easier. Regular, moderate-to-brisk physical activity can also help you to reduce fatigue and manage stress. Myth 3: The older you are, the less physical activity you need. Most people become less physically active as they age, but keeping fit is important throughout life. Regular physical activity increases older people s ability to perform routine daily tasks and to stay independent longer. No matter what your age, you can find a physical activity program that is tailored to your particular fitness level and needs. Myth 4: Taking medication interferes with physical activity. In most cases, this is not true. In fact, becoming more active may lessen your need for certain medicines, such as high blood pressure drugs. However, before beginning a physical activity program, be sure to inform your doctor about both prescription and over-thecounter medications you are taking, so that your health can be properly monitored. Your Guide to Physical Activity and Your Heart Myth 5: You have to be athletic to exercise. Most physical activities don t require any special athletic skills. In fact, many people who have bad memories of difficult school sports have discovered a whole world of enjoyable, healthful activities that involve no special talent or training. A perfect example is brisk walking a superb, heart healthy activity. Others include bicycling, gardening, or yard work, as long as they re done at a brisk pace. Just do more of the activities you already like and already know how to do. It s that simple.
25 19 Taking Precautions Some people should get medical advice before starting, or significantly increasing, physical activity. Check with your doctor first if you: Are over 50 years old and not used to moderately energetic activity. Currently have a heart condition, have developed chest pain within the last month, or have had a heart attack. (Also see the section, After a Heart Attack. ) Have a parent or sibling who developed heart disease at an early age. Have any other chronic health problem or risk factors for a chronic disease. Tend to easily lose your balance or become dizzy. Feel extremely breathless after mild exertion. Are on any type of medication. After a Heart Attack Following a heart attack, some people are afraid to be physically active. But it s important to know that regular, moderate physical activity can help reduce your risk of having another heart attack and actually improve your chances of survival. Being active can also help you to more easily perform everyday tasks and to do so without chest pain or shortness of breath. If you ve had a heart attack, it s important to consult your doctor to be sure you re following a safe and effective physical activity program. Your doctor s guidance can help prevent heart pain and/or further damage from too much exertion. Ask about getting involved in cardiac rehabilitation, which is a total program for heart health that includes exercise training, education, and counseling to help you return to an active life. Getting in Motion
26 20 Choosing the Right Activity The key to a successful fitness program is choosing an activity or activities that will work well for you. Here are some questions to ask yourself to help you find a good movement match. 1. How physically fit are you? If you ve been inactive for a while, you may want to start with walking, biking, or swimming at a comfortable pace. Beginning with less strenuous activities will allow you to become gradually more fit without straining your body. If you re not sure how physically fit you are, you may want to visit a qualified exercise professional at a local health club or recreation center to receive a fitness assessment. A brief series of physical tests can estimate your current aerobic capacity, strength, and flexibility, as well as measuring your height, weight, and blood pressure. This information can give you a good picture of the shape you re in and allow you to choose activities and goals that are right for you. 2. What kinds of benefits do you want from physical activity? Aerobic activity benefits the heart and lungs most. Resistance exercises can provide some aerobic conditioning, while also strengthening and toning muscles. Stretching exercises help to keep muscles limber, thereby preventing injury during your physical activity. (See Types of Physical Activity on page 11 for more on each form of activity.) The most healthful physical activity program includes all three types of movement. Your Guide to Physical Activity and Your Heart 3. Do you prefer to be active on your own, or with others? Do you lean toward individual activities, such as swimming or weight lifting; two-person activities, such as dancing; or group sports, such as softball or doubles tennis? If you like to be active with others, consider whether you can find a partner or group easily and quickly. If not, choose another activity until you can find a partner. If you prefer do-it-yourself activities, it may be simpler to get started but a bit more challenging to maintain your momentum. Choosing an activity you truly enjoy will help you to stay with your activity program.
27 21 4. Do you prefer to be active outdoors or in your home? Both have advantages. Outdoor activities offer variety in scenery and weather. Indoor activities offer shelter from bad weather and the convenience of not having to step beyond your front door. Some activities, such as bench stepping or running in place, can be done indoors or outdoors. If your activity can be seriously affected by weather, consider choosing a second, alternate activity that you can do at home or in a gym. 5. Are you looking for an inexpensive way to get in shape? Many activities are free or nearly so, requiring no equipment or special clothing. For example, brisk walking requires only a comfortable pair of rubber-soled shoes. Many communities offer free or very affordable physical activity options. Check with your local park and recreation department, which may offer a number of low-cost physical activity classes that are enjoyable for the entire family. 6. Would you like to join a gym or work with a fitness professional? Some people find that regularly going to a health club, and/or working with a fitness trainer, helps them to stay more motivated. Before you purchase a gym membership or sessions with a professional, be sure to shop around and ask questions. Check out the certifications and education of the staff to ensure that they are properly qualified. Professional qualifications include a college degree in a health-related field, such as exercise science or physical education. Ideally, staff should hold an exercise certification from a nationally recognized, nonprofit organization, such as the American College of Sports Medicine. Ask to speak to a few current clients to find out about the quality, size, and availability of sessions. Pay a visit to the facilities to check out the availability and quality of the equipment, the accessibility of parking, and the travel time from your home or office. Getting in Motion
28 22 BILL KIRWAN I realize I m not as young as I used to be. I began working out doing both weights and cardio work. Over time, the more I exercised, the more I built up and increased the weights, the more I began to see the benefits. It s a stress reliever. I m the father of two young boys and they are very active in sports, and now I have the ability to do more of that with them. Your Guide to Physical Activity and Your Heart
29 23 Find out about all costs in advance. Fees for fitness services can vary greatly, so be sure to do a cost comparison of gyms and fitness professionals in your area. 7. What is the best time of day for you to be active? Do you feel more like being active in the morning, afternoon, or evening? If you can, schedule your workouts for times when you feel reasonably energetic. Remember that physical activity sessions can be spread out over the day and needn t take more than 10 minutes at a time. Smart Moves Once you find a physical activity that s a good match for you, you re ready for action! But be sure to pace yourself. Each session to condition your heart and lungs should include the following: Warmup (5 minutes). Start your physical activity session at a slowto-medium pace to give your body a chance to warm up and get ready for more vigorous movement. Gradually increase your pace by the end of the warm-up period. For especially strenuous activities, such as jumping rope or jogging, warm up for up to 10 minutes. Be active. Slowly increase your physical activity time until you reach your goal of 30 to 60 minutes daily. To condition your heart and lungs, you should engage in your activity in your target heart rate zone. (See Tracking Your Target Heart Rate on page 24.) But don t focus on big goals in the beginning. If you haven t been active in a while, you might start with just 5 10 minutes of activity per day or whatever amount of time you re comfortable with. Build up gradually. Enjoy yourself. Cool down (5 minutes). After being active, slow down gradually. For example, if you ve been swimming, begin to do your stroke more slowly, or switch to a more leisurely type of stroke. You can also cool down by changing to a less vigorous activity, such as moving from jogging to walking. This process allows your body to relax gradually. Stopping abruptly can cause dizziness. Getting in Motion
30 24 Stretch. It s best to do stretching exercises after your activity period, to increase muscle and joint flexibility. Below are several stretches you can use after your cool-down period. Each of these moves helps to stretch different parts of your body. Do each stretch slowly and steadily, without bouncing. Calf wall push. Stand facing a wall, about 1 1 /2 feet away from it. Then lean forward and push your hands against the wall, keeping your heels flat. Count to 10 (or to 20 for a longer stretch). Rest. Repeat. Hamstring palm touch. Stand with your knees slightly bent. Then, bend from the waist and try to touch your palms to the floor. If you can t reach all the way to the floor, just go as far as you can. Count to 10 or 20, then rest. Repeat. If you have lower back problems, do this stretch with your legs crossed. Hamstring toe touch. Place your right leg level with your hip on a stair, chair, or other steady object. With your other leg slightly bent, lean forward and slowly try to touch your right toe with your right hand. Hold and count to 10 or 20. Repeat with your left hand. Then switch legs and repeat with each hand. Rest. Repeat the entire stretch. Overhead triceps stretch. Bend your right elbow and use your left arm to bring it up behind your head. You should feel a gentle stretch on the outside of your upper right arm. Hold for 10 to 20 seconds. Repeat with the left elbow behind your head. Rest. Repeat. Your Guide to Physical Activity and Your Heart Standing quadriceps stretch. Place your left hand on a chair or wall for support, bend your right knee, and reach back with your right hand to grab the top of your right foot. Hold for 10 to 20 seconds. Repeat on the left side. Rest. Repeat. Tracking Your Target Heart Rate As you become more physically active, how will you know whether you re improving your heart and lung fitness? The best way is to track your target heart rate during your activity. Your target heart rate is a percentage of your maximum heart rate, which is the fastest
31 25 Finding Your Target Heart Rate Zone Target Heart Rate Maximum Heart Age Zone: 50 75% Rate: 100% beats per min. 200 beats per min beats per min. 195 beats per min beats per min. 190 beats per min beats per min. 185 beats per min beats per min. 180 beats per min beats per min. 175 beats per min beats per min. 170 beats per min beats per min. 165 beats per min beats per min. 160 beats per min beats per min. 155 beats per min beats per min. 150 beats per min. your heart can beat, based on your age. Unless you re in excellent physical condition, any physical activity that boosts your heart rate above 75 percent of your maximum rate is likely to be too strenuous. By the same token, any activity that increases your heart rate to less than 50 percent of your maximum rate gives your heart and lungs too little conditioning. Getting Into the Zone The most healthful activity level uses percent of your maximum heart rate. This range, called your target heart rate zone, is shown above. During the first few months of your activity program, aim to reach 50 percent of your maximum rate. As you get into better shape, you can slowly build up to 75 percent. Keep in mind that getting into the zone doesn t mean pushing yourself to the limit. For example, while walking briskly or jogging, you should be able to keep up a conversation without trouble. If you can t, move a bit more slowly. Overall, a gentle, gradual Getting in Motion
32 26 approach will help you to maximize your gains and minimize your risks. (See A Sample Walking Program on page 27 and A Sample Jogging Program on page 28.) What s Your Number? To find your target heart rate zone, look for the age closest to yours in the table on page 25. For example, if you re 40, your target zone is beats per minute. If you re 53, the closest age on the chart is 55, so your target zone is beats per minute. Be aware that the figures in the table are averages, so use them as general guidelines. A Note About Medications A few high blood pressure medicines lower the maximum heart rate and thus the target zone rate. If you re taking high blood pressure medications, contact your doctor to report your target heart rate zone and to find out whether your activity program needs to be adjusted. Taking Your Pulse To find out whether you re within your target heart rate zone, take your pulse immediately after finishing your activity. Here s how: As soon as you stop your activity, place the tips of your first two fingers lightly over one of the two blood vessels on your neck, located to the left and right of your Adam s apple. Another convenient pulse spot is on the inside of your wrist, just below the base of your thumb. Count your pulse for 10 seconds and multiply by six. Your Guide to Physical Activity and Your Heart If your pulse falls within your target zone, your activity is providing good benefits for your heart and lungs. If you re below your target heart rate zone, move just a bit faster next time, as long as you continue to feel reasonably comfortable doing so. If you re above your target zone, move a little more slowly. Don t try to move at, or very close to, your maximum heart rate that s working too hard. Eventually, you ll be consistently engaging in your activity within your target zone. To continue to track your progress, keep checking your pulse after at least one activity session per week.
33 27 A Sample Walking Program During each week of the program, try to walk briskly at least 5 days per week. Always start with a 5-minute, slower-paced walk to warm up, and end with a 5-minute, slower-paced walk to cool down. (Warm-up and cool-down sessions totaling 10 minutes are included in the total time column.) As you walk, check your pulse periodically to see whether you re moving within your target heart rate zone. Week Warm up Target zone Cool down Total time Week 1 Walk 5 min. Walk briskly 5 min. Walk 5 min. 15 min. Week 2 Walk 5 min. Walk briskly 7 min. Walk 5 min. 17 min. Week 3 Walk 5 min. Walk briskly 9 min. Walk 5 min. 19 min. Week 4 Walk 5 min. Walk briskly 11 min. Walk 5 min. 21 min. Week 5 Walk 5 min. Walk briskly 13 min. Walk 5 min. 23 min. Week 6 Walk 5 min. Walk briskly 15 min. Walk 5 min. 25 min. Week 7 Walk 5 min. Walk briskly 18 min. Walk 5 min. 28 min. Week 8 Walk 5 min. Walk briskly 20 min. Walk 5 min. 30 min. Week 9 Walk 5 min. Walk briskly 23 min. Walk 5 min. 33 min. Week 10 Walk 5 min. Walk briskly 26 min. Walk 5 min. 36 min. Week 11 Walk 5 min. Walk briskly 28 min. Walk 5 min. 38 min. Week 12 Walk 5 min. Walk briskly 30 min. Walk 5 min. 40 min. Week 13 Walk 5 min. Continue. Walk 5 min. on: (See below.) As you become more fit, try to walk within the upper range of your target zone. Gradually increase your brisk walking time from 30 to 60 minutes, most days of the week. Enjoy the outdoors! Getting in Motion
34 28 A Sample Jogging Program Your Guide to Physical Activity and Your Heart During each week of the program, try to jog at least 5 days per week. For your warm up, walk for 5 minutes. For your cool down, walk for 3 minutes and then stretch for 2 minutes more. (Warm-up and cool-down sessions totaling 10 minutes are included in the total time column.) As you jog, check your pulse periodically to see whether you re moving within your target heart rate zone. If you re over 40 and haven t been active in a while, begin with the walking program. After you complete the walking program, start with Week 3 of the jogging program. Week Warm up Week 1 Walk 5 min., then stretch Week 2 Walk 5 min., then stretch Week 3 Walk 5 min., then stretch Week 4 Walk 5 min., then stretch Week 5 Walk 5 min., then stretch Week 6 Walk 5 min., then stretch Week 7 Walk 5 min., then stretch Week 8 Walk 5 min., then stretch Week 9 Walk 5 min., then stretch Week 10 Walk 5 min., then stretch Week 11 Walk 5 min., then stretch Week 12 Walk 5 min., then stretch Week 13 Walk 5 min., then stretch Week 14 Walk 5 min., then stretch Week 15 Walk 5 min., then stretch Week 16 on: Walk 5 min., then stretch
35 29 Jogging in your Total target zone Cool down time Walk 10 min. Try to walk Walk 3 min., stretch 2 min. 20 min. without stopping. Walk 5 min., jog 1 min., Walk 3 min., stretch 2 min. 22 min. walk 5 min., jog 1 min. Walk 5 min., jog 3 min., Walk 3 min., stretch 2 min. 26 min. walk 5 min., jog 3 min. Walk 4 min., jog 5 min., Walk 3 min., stretch 2 min. 28 min. walk 4 min., jog 5 min. Walk 4 min., jog 5 min., Walk 3 min., stretch 2 min. 28 min. walk 4 min., jog 5 min. Walk 4 min., jog 6 min., Walk 3 min., stretch 2 min. 30 min. walk 4 min., jog 6 min. Walk 4 min., jog 7 min., Walk 3 min., stretch 2 min. 32 min. walk 4 min., jog 7 min. Walk 4 min., jog 8 min., Walk 3 min., stretch 2 min. 34 min. walk 4 min., jog 8 min. Walk 4 min., jog 9 min., Walk 3 min., stretch 2 min. 36 min. walk 4 min., jog 9 min. Walk 4 min., jog 13 min. Walk 3 min., stretch 2 min. 27 min. Walk 4 min., jog 15 min. Walk 3 min., stretch 2 min. 29 min. Walk 4 min., jog 17 min. Walk 3 min., stretch 2 min. 31 min. Walk 2 min., jog slowly Walk 3 min., stretch 2 min. 31 min. 2 min., jog 17 min. Walk 1 min., jog slowly Walk 3 min., stretch 2 min. 31 min. 3 min., jog 17 min. Jog slowly 3 min., jog 17 min. Walk 3 min., stretch 2 min. 30 min. Continue. (See below.) Walk 3 min., stretch 2 min. As you become more fit, try to jog within the upper range of your target zone. Gradually, increase your jogging time from 20 to 30 minutes (or up to 60 minutes, if you wish). Keep track of your goals and keep on enjoying yourself. Getting in Motion
36 30 JOSE HENRIQUEZ I was overweight. I was told by my doctor that if I kept it up I was going to develop high blood pressure and high blood cholesterol. Once I realized no one was going to take care of me except me, I started eating better and exercising. I go to a gym every day from Monday through Friday. I take a spinning class, I do weight lifting, and I use the machines. I feel younger when I go to the gym, like I can do anything. When I don t go to the gym I can tell the difference my stamina is gone.
37 31 Playing It Safe By and large, physical activity is a very safe way to help protect your heart. But like anything else you do, getting fit requires taking a few common-sense precautions. Following are some important safety tips: Avoid Injury It can t be said too often: Start your activity program gradually, and work up slowly. Be sure to warm up, cool down, and stretch each and every time you are physically active. Exercising too much, too fast, can cause injuries. A certain amount of stiffness is normal at first. But if you do hurt a joint or pull a muscle, stop the activity for several days to avoid more serious injury. Rest and over-the-counter painkillers can heal most minor muscle and joint problems. Use proper equipment. Wear good shoes with adequate cushioning in the soles for jogging or walking. Use goggles to protect your eyes for sports such as handball or racquetball. Joggers should run on soft, even surfaces such as a level grass field, a dirt path, or a track. Hard or uneven surfaces, such as cement or rough fields, are more likely to cause injuries. Also, try to land on your heels, rather than on the balls of your feet, to minimize strain on your feet and lower legs. If you jog or walk on the street, watch for cars. Wear lightcolored clothing with a reflecting band at night so that drivers can see you more easily. Always face oncoming traffic. Remember, drivers can t see you as well as you can see their cars. If you bicycle, always wear a helmet. Ride in the direction of traffic and try to avoid busy streets. At night, use lights and wheel-mounted reflectors. Playing It Safe
38 32 Eat Right If you ve just eaten a meal, avoid strenuous physical activity for at least 2 hours. If you ve just been vigorously active, wait about 20 minutes before eating. If you plan to be continuously active for more than 60 minutes, you may want to take a snack along to keep up your energy level. Good choices are light foods and drinks that are high in carbohydrates, such as bananas, raisins, bagels, or sport drinks. Check the Weather Report On hot, humid days: Try to be physically active during the cooler and less humid parts of the day, such as early morning or early evening. Wear light, loose-fitting, breathable clothing. Never wear rubberized or plastic suits. Such clothing won t help you lose weight by making you sweat more, but it can cause dangerously high body temperatures. Drink adequate fluids particularly water before, during, and after your physical activity. Watch for symptoms of heat exhaustion and heat stroke. (See the box on page 33, Taking Too Much Heat. ) Your Guide to Physical Activity and Your Heart On cold days: When dressing for outdoor activity, wear one layer less than you d wear if you were outside but not physically active. Ideally wear several layers of clothing rather than one heavy jacket, so you can remove a layer if you get too warm. Use mittens, gloves, or cotton socks to protect your hands. Wear a hat, since up to 40 percent of your body heat is lost through your head and neck.
39 33 Taking Too Much Heat When you re active outdoors in hot, humid weather, be alert for signs of heat exhaustion and heat stroke. Although many of their symptoms are similar, heat stroke is the more serious condition. Heat stroke occurs when the body temperature increases too much, causing stress on the body that may harm tissues. The rise in temperature occurs when the heat produced during exercise exceeds the heat that leaves the body. The following are the main symptoms of each type of heat problem: Heat Exhaustion Dizziness Headache Nausea Confusion Body temperature below normal Heat Stroke Dizziness Headache Nausea Confusion Muscle cramps Sweating stops High body temperature Both heat exhaustion and heat stroke can be avoided by drinking enough water to replace fluids lost during physical activity. Drink water regularly throughout your activity, but don t over water yourself. Drink no more than 3 cups of water per hour. Playing It Safe
40 34 On rainy, icy, or snowy days: Be aware of reduced visibility for both yourself and for drivers and reduced traction on roadways. Seek Company If you re concerned about the safety of your surroundings, pair up with a buddy for outdoor activities. If possible, walk, bike, or jog during daylight hours. Check out the hours of nearby shopping malls. Many malls are open early and late for people who prefer to walk or jog at those times of day, but in a safe, well-lit area. (Indoor malls also make it possible to stay active during summer heat, winter cold, and allergy seasons.) Know the Signs of a Heart Problem While physical activity can strengthen your heart, some types of activity may worsen existing heart problems. Warning signals include sudden dizziness, cold sweat, paleness, fainting, extreme breathlessness, or pain or pressure in your upper body. These symptoms may occur during, or just after, an activity. Ignoring these signals and continuing your activity may lead to serious heart problems. Instead, call your doctor right away. Get Back in the Swing Your Guide to Physical Activity and Your Heart If you have to miss a few sessions of physical activity because of illness or injury, don t be discouraged. Once you recover, you can get right back on the activity track. But do wait until you recover. If you come down with a minor illness, such as a cold, wait until you feel normal before you resume your activity. If you suffer a minor injury, wait until the pain disappears before continuing. When you do resume your fitness sessions, start at one-half to two-thirds of your previous level, depending on the number of days you ve missed and how you feel while moving.
41 35 If your activity program has been interrupted by a major illness or injury, consult your doctor about the best time and pace for resuming your fitness program. Whatever your reasons for missing sessions, don t worry about the skipped days or weeks. Just get back into your routine and focus on the progress you ll be making toward your fitness goals. Playing It Safe
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There is good news for those who have an unwanted body design. Newer laser tattoo removal techniques can eliminate your tattoo with minimal side effects.Lasers remove tattoos by breaking up the pigment colors of the tattoo with a high-intensity light beam.
Q Switch NdYAG (1064nm) Laser for tattoo removal is an effective treatment with very little risk of scarring. Laser treatment is often safer than many traditional methods such as excision, dermabrasion because of its unique ability to selectively treat pigment involved in the tattoo.
In many cases, certain colors may be more effectively removed than others. It is known that blue/black tattoos respond particularly well to laser treatment. Other colors are treated by Q Switch NdYAG (532nm) lasers based upon the pigment color.


We’re having a beautiful and very colourful Autumn again this year, very cold but following last weeks Snowfall it’s been predominantly clear and sunny.
I’m in full on prep for the winter which includes getting all my kit together, organizing courses and getting into shape for the season ahead.
For the past year I’ve been following a super easy morning stretching ritual. I basically start at the top, my head, and work my way down to my feet rolling and flexing all my joints through the movements ranges that they are made to make on a daily basis. Through experience I’ve found that if you have a morning workout that is to vigorous then you grow to dread following it and after a while you start to miss one or two out and then eventually its history. This time, I made the ritual super easy, it takes 20 minutes and you can add to it if you have more time. Because its easy and does the job I’ve managed to follow it everyday now for over a year. It’s definitely helping and fits my Dad’s lifestyle mantra of KISS – Keep it simple stupid!
Since getting back to Chamonix I’ve also started running. The weather has been cold and clear and so I’ve been getting out for a good run up and down the valley with the dogs and Ruth, who is a better runner than me, comes out every now and then to up my pace and kick my ass. I’ve never enjoyed running before but its to cold for the bike and I’m actually really enjoying it at the moment and I try to get out everyday for an hour or two. I’m going to try to keep it going through out the winter if I can, so anyone coming to Tignes on the pre season courses, bring your running shoes if you want!
I’ve also started to do a lot of plyometric work, working with natural movements and body weight, lunges, one legged squats, split squats etc. and I’ve added upper body work back into my fitness routine with pull ups and press ups. Again, no weights just body weight exercises working on perfect form and free movement.
I’m trying to work on natural movements and promote good natural health and so far it feels great…well in a really painful stiff legged morning sort of way!
I’m trying to think about how I move and how I use my body a lot, trying to break routines, stand up differently, get dressed differently, break habits and learn new movement patterns which promote a more balanced muscle memory pattern and I’m looking forward to applying all of this to my riding this winter.
Well its not long until kick off now and so, if you’ve not already started, its time to get your health program going or to ramp it up a notch. Nothing to strenuous that will cause a last minute injury but something that will make it interesting and keep you at it.
I have places on my pre season Slackcountry Splitboard course in Tignes so if you’re after a pre season split fest give Ruth a shout…oh and don’t forget your running shoes!


How to improve the availability of veterinary vaccines in Europe
EMA publishes workshop report on requirements for the authorisation of vaccines
The European Medicines Agency (EMA) has published today the outcome of a workshop which explored how to ensure the availability of veterinary vaccines in the European Union (EU).
The availability of a wide range of veterinary vaccines is critical for the protection of animal health. Veterinary vaccines may protect human health, too, in those cases where they are used to prevent outbreaks of diseases in animals that can be transmitted to man, especially in animals that are intended for human consumption. Vaccines can also reduce the need for antibiotics, helping to stem the risk of antimicrobial resistance.
The workshop was jointly organised by EMA and Heads of Medicines Agencies (HMA) on 25 March 2015 and brought together experts from national competent authorities, the veterinary/pharmaceutical industry, and EMA. The participants examined the reasons why more veterinary vaccines are not currently available and discussed if the level of requirements for the authorisation of veterinary vaccines in the current legal framework is well balanced or might in some cases discourage potential applicants.
The workshop concluded that several factors combine to make the EU market less attractive for the authorisation of vaccines than other regions which might lead to a lack of availability of certain vaccines. The reasons for reduced availability are complex and multifactorial and differ depending on the type of vaccine concerned, such as vaccines for companion animals, for livestock, for treating major diseases, for treating minor diseases, or for treating outbreaks of epizootics diseases such as Foot-and-Mouth disease or Bluetongue.
The workshop concluded with a series of recommendations intended to improve this situation whilst maintaining a high level of protection of animal and human health, and of the environment. These include:
- increase predictability of regulatory outcomes for applicants through early and/or enhanced engagement in the development of scientific and administrative guidelines for veterinary vaccines;
- identify and propose specific training for regulatory assessors to enhance consistency of assessment and share experience;
- examine the feasibility of preparing lists of diseases for which vaccines are not available, and are therefore required, together with clear expectations of what would be needed for their authorisation;
- examine the factors identified by the industry as constraining the availability of vaccines within the EU;
- take the opportunity of the ongoing revision of the guidelines on data requirements for products for minor use, minor species (MUMS) to explore the scope for further reduction of data requirements for this type of product;
- Use the outcome of the workshop to enrich the discussions on authorisation of vaccines in the European Council and Parliament on revision of the legislation governing veterinary medicines.
This meeting report and its recommendations will form the basis for a joint EMA/HMA action plan to improve the availability of veterinary vaccines in the EU, involving industry and other experts in its preparation and implementation.


Contact Dr. Lu for information about cancer treatments。聯繫盧博士，獲取有關癌症治療資訊。
[Voice of Hope June 1, 2023] (Editor: Li Wenhan) Have you ever wondered why some people can live to be over a hundred years old, and they are healthy and energetic? Do they have any special secret? The secret to centenarians’ longevity may lie in their guts, new research has found.
Recently, “Nature Aging” published a new study: after analyzing the intestinal flora of 297 centenarians in Guangxi, China, researchers found that centenarians have their own unique intestinal type, similar to young people’s intestinal flora structure and Higher bacterial diversity. This may be the key to longevity.
Gut flora (Voice of Hope Synthesis)
What role do gut microbiota play in health?
Gut flora refers to the trillions of microbes that inhabit our gut, including bacteria, fungi, viruses, and more. These microorganisms not only help us digest food, but also participate in the regulation of our immune system, metabolic system, nervous system and other aspects.
The balance and diversity of gut flora is crucial to our health, and the imbalance or monotony of gut flora may lead to various diseases, such as obesity, diabetes, cardiovascular disease, autoimmune disease, neurodegeneration disease etc.
What are the characteristics of the intestinal flora of centenarians?
A research paper on Japanese centenarians was published in the journal “Nature“, revealing the mystery of their longevity hidden in inconspicuous places.
Japanese scientists studied 160 centenarians (average age 107 years old), and found that long-lived elderly people have unique intestinal flora, and special metabolites can inhibit the growth of intestinal pathogens, reduce inflammation, and promote health.
Specifically, there is a highly enriched type of bacteria in the intestinal flora of centenarians, which can produce a unique set of secondary bile acids through a new biosynthetic pathway.
These secondary bile acids have several important roles, such as regulating the body’s metabolism and immune response, and inhibiting the proliferation of harmful bacteria in the gut.
One of these bile acids, called isoalloLCA, is a potent antimicrobial that, at very low concentrations, can inhibit certain enteric pathogens that have become drug-resistant.
Visible under an electron microscope, isoalloLCA caused Clostridium difficile and Enterococcus faecalis (VRE) to deform and ultimately kill these pathogens.
The researchers also screened dozens of strains of bacteria from the fecal microbes of a centenarian, identified bacterial species that specifically produce isoalloLCA, and mapped the genes and biological enzymes they required in bile acid metabolism.
In follow-up studies, they will further verify the association between bile acids and longevity.
What are the characteristics of a centenarian’s diet?
1. Eat more carbohydrates. In the above studies, according to the paper report, the largest source of calories for centenarians in Guangxi is carbohydrates, accounting for more than 60%. This shows that carbohydrates are necessary for longevity.
2. Eat less animal protein and less cholesterol. Centenarians consume only 12% of the high-quality protein that is always talked about. Most of the protein comes from legumes, and if cereals are the main food throughout the day, then protein is 10% of total calorie sources.
3. Take in more dietary fiber. Most of their food composition is coarse grains, and they eat whole grains, potatoes, beans, etc. every day, which form their main carbohydrates and their main source of calories.
Although their calorie intake is low, their dietary fiber content is high. This is a high-fiber dietary pattern, which makes the diversity of their intestinal bacteria closer to the intestinal ecology of young people.
It can be seen that this is a high-carbohydrate, low-protein, high-fiber, high-nutrient diet pattern, which is very similar to the Japanese Okinawa diet pattern.
How to improve our gut flora?
Here are some simple but effective suggestions:
Eat foods rich in prebiotics, such as whole grains, beans, onions, garlic, bananas, etc. These foods can provide nutrients for the beneficial bacteria in the gut.
Appropriate supplementation of probiotics or fermented foods, such as yogurt, sauerkraut, soy milk, etc., can increase the number and types of beneficial bacteria in the intestines.
Eat less high-fat, high-sugar, high-salt, and highly processed foods, which can lead to an imbalance of intestinal flora and inflammation.
Maintain a moderate amount of exercise, exercise can promote intestinal peristalsis, increase blood circulation, and improve the intestinal microenvironment.
Maintain good sleep and mood, sleep and mood can affect our hormone levels and neurotransmitters, which in turn affect our gut flora.
Whole Grain Food, Cereal (Pixabay)
In conclusion, the gut microbiota is an important and neglected system in our body that is closely related to our health and longevity. Centenarians possess unique and optimized gut microbiota, which may be an important factor in their longevity.
We can learn from their lifestyle and eating habits to improve our own gut flora, thereby improving health and longevity.
Editor in charge: Li Zhi
This article or program is edited and produced by Voice of Hope. Please indicate Voice of Hope and include the original title and link when reprinting.
More about this source textSource text required for additional translation information
Originally published on https://www.soundofhope.org/post/720686


The other day, I met an older woman who talked about her son. At age 14, with youthful adventure, he took illegal drugs for the first time which had a profound impact on his developing mind. The mom quickly learned addiction was a mental disease. Like cancer, it can keep coming back again and again.
The mom talked about how strong family support, love and forgiveness is needed to regain control and develop a normal life. On one random day, despite making progress, the drugs overpowered him…bringing him and his family back to square one.
The mom remembers a particular phone call that terrified her. She thought, “would it be a cheerful ‘hi mom’ or a ‘this is the police’ type of call?” She never knew what to expect. Sadly, 20 years later, her son died of a drug overdose. He was 34.
As a result of her son’s death, the mom has become an advocate for getting rid of illegal drugs. Good drugs are properly restored. This includes drugs for pets as well. All unnecessary drugs are a strong temptation to an adventurous young mind.
Sheriff Craddick will be at the Market Street Pharmacy at Food Country on Saturday, April 28, from 10 a.m. to 2 p.m. to take in all of your unused solid drugs. Not questions will be asked. Just a warm thank you for helping out.
-Paul Paradzinski, Craig County Prevention Team


Sorafenib-Associated Psoriasiform Eruption in a Patient With Hepatocellular Carcinoma
August 2014 | Volume 13 | Issue 8 | Editorials | 899 | Copyright © August 2014
Turna İlknur MD,a Sevgi Akarsu MD,a
Saim Çarşanbalı MD,a Banu Lebe MD,b
and Emel Fetil MDa
aDokuz Eylül University, Faculty of Medicine, Department of Dermatology, İzmir, Turkey
bDokuz Eylül University, Faculty of Medicine, Department of Pathology, İzmir, Turkey
To our knowledge, there have been only a few reported
cases of psoriasiform eruption associated with sorafenib
therapy.1-6 Although drug-induced psoriasiform eruptions are
indistinguishable from idiopathic psoriasis, they may be differentiated
histologically by the absence of tortuous capillaries
in the dermal papillae associated with suprapapillary thinning,
and presence of eosinophils around the blood vessels of the superficial
plexus.8 While the second biopsy taken from our case
was consistent with psoriasiform drug eruption, we cannot definitively
determine if the patient’s elbow lesions were due to a
sorefanib-induced psoriasis exacerbation or psoriasiform drug
eruption. However, he reported a direct correlation between
starting sorefanib and appearence of elbow lesions.
The pathogenesis of sorefanib induced psoriasis remains
obscure, but the presence of dysfunctional CD4+CD25+ immunosuppressive
regulatory T cells leading to an imbalance
between regulatory and effector T-cell functions in patients
with psoriasis has been hypothesized to play an important role.
It has been suspected that tyrosine kinase inhibitors including
sorafenib may block the signal transduction pathways in both
regulatory and effector T cells.4 It has been also suggested that
sorafenib might alter the keratinocyte proliferation and differentiation
by a yet unknown mechanism.3
Actually, the occurrence of psoriasiform eruptions in patients
associated with sorafenib seems paradoxical. In recent trials,
the spectrum of diseases in which kinase inhibitors are used has
increasingly expanded to include immune-mediated diseases.
It was proposed that blocking kinases may be an effective way
to inhibit immune cell activation and abnormal epidermal angiogenesis,
involved in the pathogenesis of psoriasis. To this
respect, a patient with metastatic hypernephroma and concomitant
recalcitrant psoriasis who responded well to sorafenib has
been reported.9 More recently, novel protein kinase inhibitors
are also under clinical investigation based on this hypothesis
for treatment of psoriasis.10
Consequently, the pathogenesis of sorafenib-induced psoriasiform
eruptions is difficult to explain. Further molecular
investigations exploring the connection between sorafenib and
psoriasis may increase our understanding of this issue.
None of the authors have declared any relevant conflicts.
- Laquer V, Saedi N, Dann F, Kelly K. Sorafenib-associated psoriasiform skin
changes. Cutis. 2010; 85: 301-2.
- Diamantis ML, Chon SY. Sorafenib-induced psoriasiform eruption in a patient
with metastatic thyroid carcinoma. J Drugs Dermatol. 2010; 9: 169-71.
- González-López MA, González-Vela MC, Yáñez S et al. Psoriasiform skin
eruption associated with sorafenib therapy. Indian J Dermatol Venereol Leprol. 2011; 77: 614-5.
- Hung CT, Chiang CP, Wu BY. Sorafenib-induced psoriasis and hand-foot skin
reaction responded dramatically to systemic narrowband ultraviolet B phototherapy. J Dermatol. 2012; 39: 1076-7.
- Maki N, Komine M, Takatsuka Y et al. Pustular eruption induced by sorafenib
in a case of psoriasis vulgaris. J Dermatol. 2013; 40: 299-300.
- Du-Thanh A, Girard C, Pageaux GP et al. Sorafenib-induced annular pustular
psoriasis (Milian-Katchoura type). Eur J Dermatol. 2013; 23:900-1.
- Otsuka T, Eguchi Y, Kawazoe S et al. Skin toxicities and survival in advanced
hepatocellular carcinoma patients treated with sorafenib. Hepatol Res. 2012;
- Justiniano H, Berlingeri-Ramos AC, Sánchez JL. Pattern analysis of druginduced
skin diseases. Am J Dermatopathol. 2008; 30: 352-69.
- Fournier C, Tisman G. Sorafenib-associated remission of psoriasis in hypernephroma:
case report. Dermatol Online J. 2010; 16: 17.
- Menter A, Papp KA, Tan H et al. Efficacy of tofacitinib, an oral janus kinase
inhibitor, on clinical signs of moderate-to-severe plaque psoriasis in different
body regions. J Drugs Dermatol. 2014;13:252-6.


November 24, 2020
L Hou et al, 2020. The combination of T-2 toxin and acrylamide synergistically induces hepatotoxicity and nephrotoxicity via the activation of oxidative stress and the mitochondrial pathway, Toxicon, published online.
T-2 toxin is a common fungal toxin, which is not only widely found in wheat, barley, corn, and other food crops and their related products, but also in various animal feeds. Acrylamide (ACR) is mainly formed by the free amino acid, asparagine and reducing sugars, such as glucose and fructose, and is commonly found in potato chips, French fries, toast, coffee, and other foods. Therefore, people are highly likely to consume food via their daily diets that are contaminated with both T-2 toxin and ACR. Since liver and kidneys were possible toxic targets of both T-2 toxin and ACR, this study assessed whether combined exposure could increase hepatotoxicity and nephrotoxicity using both cell cultures and animal models. We used L02 and MARC-145 cells and treated with T-2 toxin (5-15 nM) and ACR (1-3 mM) alone or in combination with a fixed ratio of 1:200 (T-2 toxin/ACR). ACR (50 mg/kg, i.g., 5d) and T-2 toxin (5 mg/kg, i.g., 5d) were used to assess the biochemical, proteins and histplogical changes in C57BL/6N mice. Results showed the combination resulted in synergistic cytotoxicity in vitro, while significantly increasing liver and kidney toxicity in vivo. Mechanistically, T-2 toxin decreased Manganese superoxide dismutase expression, while ACR reduced catalase expression. These two mechanisms were converged in response to the combination, leading to enhanced oxidative stress generation. The findings highlighted the necessity to consider the combined toxicity during the safety assessment of these food-borne contaminants.
Ja tak, jeg vil gerne modtage nyhedsbrev, når der er noget nyt om kaffe og helbred.


The relative effects of leukocyte depletion and nitric oxide modulation in an ex-vivo porcine normothermic perfusion model of donation after cardiac death in the kidney
thesisposted on 14.10.2010, 10:49 by Phillip James Yates
Introduction: The shortage of donors necessitates the use of organs from donation after cardiac death (DCD) donors. These organs demonstrate a high rate of delayed graft function (DGF) and primary non-function (PNF) when compared to those from non-DCD donors. DGF and PNF are associated with shorter graft survival times. Reperfusion injury (RI) is important in the aetiology of DGF and PNF. The roles of leukocytes and nitric oxide (NO) are pivotal in the generation of RI. The aim of this study was to assess the effect on RI of modulating leukocyte and NO levels at the time of reperfusion. Methods: This study utilised a porcine extra-corporeal normothermic perfusion model of RI. Kidneys were perfused with whole (WB) or leukocyte depleted blood (LDB) alone, or with an inducible nitric oxide (iNOS) inhibitor or NO donor. This model allows the collection of haemodynamic and functional data, as well as plasma and urine for biochemical analysis. Results: Kidneys reperfused with LDB demonstrated improved blood flow and function compared to those reperfused with WB. Initial blood flow and function in the iNOS supplemented groups was worse than in the WB/LDB perfused groups, but improved in the NO donor groups. Late blood flow plateaued in the NO donor groups but improved in the iNOS supplemented WB group. LDB and iNOS supplementation together gave poor blood flow and function throughout reperfusion. Conclusion: Depletion of leukocytes abrogates the no-reflow phenomenon and reduces the oxidative stress caused by white cell infiltration, thereby improving blood flow and function. The effects of nitric oxide and its inhibition on the endothelium, glomerulus and renal tubule during initial reperfusion are dependent upon the phase of reperfusion. Early benefits to blood flow by NO supplementation are offset by the generation of NO free radicals later after reperfusion.


The 90/10 Rule
Stress management is essential for both mental and physical health, fortunately there are many resources available to support health and wellness.
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Find Relief from Teeth Grinding with Our Specialised Care
Teeth grinding, also known as bruxism, can lead to various discomforts, including migraines, headaches, neck, and shoulder pain. At Devon Place 7 Day Dental, we provide effective solutions to alleviate these symptoms. Our custom-made splints, designed for night-time use, can offer significant relief and protect your teeth from the adverse effects of grinding.
Understanding and Treating Teeth Grinding
Teeth grinding can often go unnoticed but can have a significant impact on your oral and overall health. Recognising the symptoms and seeking timely treatment is essential for preventing long-term damage. Here’s how we can help:
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Contrary to what the religious elite conveys, death is not resisted by those in great and intractable pain, who know they will not recover. In fact, at this point,
humans invariably beg to be allowed to die. They sense their family and the medical profession, hovering about the bed, are wanting them to stay on, to be with
them, not to leave, perhaps reluctant to allow the passage as they will miss the one begging for death, cannot imagine life without that beloved person, hope for a
miracle recovery, or simply cannot admit defeat. But in these matters, the decision to end ones life or the timing of this should be in the hands of the individual, not
family or medical profession and certainly not in the hands of the religious elite who assume they can control sex, birth and death, and independent thinking as part
and parcel of their power trip. Whose life is it, anyway? We, the Service-to-Other Zetas, do not believe in being dictatorial to one another, but rather in
empowering each other with knowledge. Regardless of the obvious outcome, we struggle endlessly to assist the individual who wants to live to survive. Likewise, if
an individual has determined to end their existence, we do not thwart their efforts.
In times past, or in primitive countries where the miracle of modern medicine whereby a body can be sustained in horrific pain long past the point where nature intended, death is not a mystery. Severe pain does not exist except after an injury, and where too great causes a mental blackout. Women suffer the pain of childbirth, which is as great a pain as can be sustained without passing out, and this is not considered a dire problem by the establishment. Severe pain from injury results in the body passing out, going into shock, and dying if not treated. This is nature's answer to the situation. An injury that is minor results in pain when the affected part is moved, nature's way of forcing the injured to rest until healed. Internal injuries or those resulting in infection likewise proceed, in nature, to loss of consciousness from internal bleeding or going septic, both resulting in death. Depression, in those who must live with being maimed or who cannot accept their situation, naturally results in death as the depressed person simply stops eating and drinking, a painless and quiet end of allowed to proceed.


Seltzer water is a great alternative to drinking soda. It can still give you the flavor and carbonation of soda without the downfalls from it. If regular water doesn’t do it for you, seltzer water can be just the right amount of different to help you get in your H2O, but is there something we’re overlooking? Is seltzer water bad for you?
How did we get here?
I personally am not a big fan of soda, so I have always liked seltzer water. My favorite brand is Bubbly and I drink it ALL the time. Truly I can admit that it might be a problem, but anyway, with all of the carbonation, I began to wonder what it was doing to my insides.
I always knew that when I drank it, it gave me the same burning sensation that soda did, but I always assumed that since it was water, there wasn’t a problem with it. But I thought that now would be a great time to settle this internal debate, so now we are going to find out together.
What is seltzer water and is it like soda?
In short, seltzer water is just carbonated water, so outside of the carbonation, it is very different from its soda counterpart. Soda is full of sugar and additives that contribute to how harmful it is for us to ingest.
What about my teeth?
The Journal of the American Dental Association stated that carbonated beverages like soda and fruit juices can wear on your teeth, but seltzer water is safe. That started to become dicey when looking at flavored carbonated water, however. Because of the acidity in fruits, the flavored flavors did register as having a lower pH level so they are more harmful to your dental health.
So I guess in my case all of my lime Bubbly may not be the best option to drink all the time. If you enjoy plain seltzer water, drink on! Your teeth don’t notice the difference, so drink on. If unflavored seltzer water is not something that appeals to your taste buds, then drink your flavored one in moderation. At the end of the day, it is still better for you than soda, so if you have to choose between the two, still go for the water.
So, I’m still going to drink it, How can I cut out as much risk?
If you, like me, know that cutting seltzer water out of your life is a non-starter, there are ways to still enjoy your drink without having to worry as much. Always be on the lookout for the ingredient list. Like anything you buy, you want to make sure that there are no artificial sweeteners or other harmful ingredients that you cannot pronounce.
If you can find seltzer water with only water and carbonation, that is the best route. If you need some flavor in your drink, put it in yourself. Instead of getting the water flavored with other additives that are acidic in their own right, add fresh lemon and lime to your own drink.
Unfortunately, though, this is a drink best enjoyed in moderation. As much as I would like to down four cans in one sitting (yes, I have actually done this.) it isn’t a good idea to overdo it. So, keep that in mind when you go shopping for your seltzer water.