Fatal myocarditis and cardiomyopathy have occurred with Clozaril treatment. Discontinue Clozaril and obtain a cardiac evaluation upon suspicion of these reactions. Generally, patients with Clozaril-related myocarditis or cardiomyopathy should not be rechallenged with Clozaril. Stock B, Spiteller G, Heipertz R. Austausch aromatisch gebundenen Halogens gegen OH- und SCH 3- bei der Metabolisierung des Clozapins im menschlichen Körper. Arzneimittelforschung. Rebec GV, Anderson GD. Regional neuropharmacology of the antipsychotic drugs: implications for the dopamine hypothesis of schizophrenia. Behav Assessment. purchase ranolazine online usa ranolazine
The central dopaminergic blocking effects of neuroleptic agents may precipitate or aggravate a potentially fatal symptom complex known as neuroleptic malignant syndrome NMS. NMS is observed most frequently when high-potency agents like haloperidol are administered intramuscularly, but may occur with any neuroleptic agent given for any length of time. Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, altered mental status and autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac arrhythmias. Additional signs may include elevated creatine phosphokinase, myoglobinuria, and acute renal failure. Neuroleptic agents should not be given to patients with active NMS and should be immediately discontinued if currently being administered in such patients. In patients with a history of NMS, introduction or reintroduction of neuroleptic agents should be carefully considered, since NMS may recur. cheap vidalta for
Nykiel S, Henderson D, Bhide G et al. Lithium to allow clozapine prescribing in benign ethnic neutropenia. Clin Schizophr Relat Psychoses. If you have any questions about Clozaril, please talk with your doctor, pharmacist, or other health care provider. Dutch; with English abstract. Salzman C. Mandatory monitoring of side effects the “bundling” of clozapine. N Engl J Med. After coadministration of fluvoxamine for 14 days, mean trough concentrations of clozapine and its metabolites, N-desmethylclozapine and clozapine N-oxide, were elevated about 3-fold compared to baseline steady-state concentrations.
In man, clozapine tablets 25 mg and 100 mg are equally bioavailable relative to a clozapine solution. Nielsen H. Recombinant human granulocyte colony-stimulating factor rhG-CSF; filgrastim treatment of clozapine-induced agranulocytosis. J Intern Med. Kalow W. Ethnic differences in drug metabolism. Clin Pharmacokinet. If you notice any confusion, loss of coordination, feel like you might faint or lose consciousness, or are extremely sedated contact your doctor right away. Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. buy methimazole australia
Eli Lilly and Company. Lilly announces FDA notification of class labeling for atypical antipsychotics regarding hyperglycemia and diabetes. Indianapolis, IN; 2003 Sep 17. Press release. Wilmot CA, Szczepanik AM. Effects of acute and chronic treatments with clozapine and haloperidol on serotonin 5-HT 2 and dopamine D 2 receptors in the rat brain. Brain Res. Drug Safety 30: 47-57. Claghorn J, Honigfeld G, Abuzzahab F et al. The risks and benefits of clozapine versus chlorpromazine. J Clin Psychopharmacol. If you are using the disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, swallow or chew it as desired. C occurs in any patient, interrupt clozapine therapy and obtain an ANC; carefully evaluate for severe neutropenia or infection. 1 Monitor ANC in any patient who develops fever within 2 weeks after discontinuance of clozapine. 1 If high fever is present, also consider possibility of NMS. 1 See Neuroleptic Malignant Syndrome under Cautions. Monitor all patients for these symptoms. Patients who are diagnosed with diabetes or have risk factors for diabetes obesity, family history of diabetes should have their fasting blood glucose monitored before beginning treatment and periodically during treatment. Patients who develop symptoms of hyperglycemia should have assessments of fasting glucose. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Leon CA. Therapeutic effects of clozapine. A 4-year follow-up of a controlled clinical trial. Acta Psychiatr Scand. Food and Drug Administration. Review and evaluation of clinical data for clozapine for suicidality. Geriatric patients with dementia-related psychosis are at an increased risk of death. When Clozapine Orally Disintegrating Tablets was administered after a high-fat meal, the C max of both clozapine and its active metabolite, desmethylclozapine, were decreased by approximately 20%, compared to administration under fasting conditions, while the AUC values were unchanged. This decrease in C max is not clinically significant. Therefore, Clozapine Orally Disintegrating Tablets can be taken without regard to meals. Respiratory System: Aspiration, pleural effusion, pneumonia, lower respiratory tract infection. Schmauss M, Wolff R, Erfurth A et al. Tolerability of long term clozapine treatment. Psychopharmacology. Clozapine concentrations may be increased in patients with clinically important renal impairment. 1 See Special Populations under Dosage and Administration. Chiu E, Burrows G, Stevenson J. Double-blind comparison of clozapine with chlorpromazine in acute schizophrenic illness. Aust NZ J Psychiatry. cardizem
Consult with hematology specialist to determine if neutropenia is due to BEN. 1 408 Patients with documented BEN have different ANC monitoring and treatment recommendations than the general population due to their lower baseline ANC. Clozapine Orally Disintegrating Tablets are available as 25 mg or 100 mg round, peach, orally disintegrating tablets. Blood pressure should be monitored at regular intervals, particularly during dosage escalation or whenever dosage has been altered, and patients should be advised not to rise abruptly from a sitting or recumbent position. Scholz E, Dichgans J. Treatment of drug-induced exogenous psychosis in parkinsonism with clozapine and fluperlapine. Eur Arch Psychiatry Neurol Sci. Gardner EL, Seeger TF. Neurobehavioral evidence for mesolimbic specificity of action by clozapine: studies using electrical intracranial self-stimulation. Biol Psychiatry. Muller T, Becker T, Fritze J. Neuroleptic malignant syndrome after clozapine plus carbamazepine. Lancet. Benign Ethnic Neutropenia BEN. Use with caution. The effects may be increased because of slower removal of the medicine from the body. The 25 mg tablets are peach, round, unscored tablets debossed with C over 25 on one side of the tablet and blank on the other side. Clin Psychiatry 60 1: 36-40.
The 100 mg tablets are peach, round, unscored tablets debossed with C over 100 on one side of the tablet and blank on the other side. The diagnostic evaluation of patients with this syndrome is complicated. Reduce the dose gradually over a period of 1 to 2 weeks if termination of Clozaril therapy is planned and there is no evidence of moderate to severe neutropenia. Check with your doctor before you drink alcohol or use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are using Clozaril; it may increase their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. If you have been using this medicine regularly, do not stop taking it without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. This is to help prevent the illness from suddenly returning and to decrease the chance of having symptoms such as headache, nausea, vomiting or diarrhea. See Severe Neutropenia under Cautions. Women and patients of Jewish background may be at greater risk of developing blood problems with Clozaril. Neutropenia reported in clozapine-treated patients. AstraZeneca Pharmaceuticals. Seroquel quetiapine fumarate tablets prescribing information. Wilmington, DE; 2004 Jul. Consider the risk of exacerbation of psychosis when discontinuing or changing treatment with antipsychotic medications during pregnancy and postpartum. Neuroleptic malignant syndrome NMS a potentially fatal syndrome characterized by hyperpyrexia, muscle rigidity, altered mental status, and autonomic instability, reported with antipsychotic agents, including some cases with clozapine therapy alone or during concomitant therapy with carbamazepine, lithium, or other CNS-active agents. Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care. There have not been sufficient numbers of geriatric patients in clinical studies utilizing Clozapine Orally Disintegrating Tablets to determine whether those over 65 years of age differ from younger subjects in their response to Clozapine Orally Disintegrating Tablets. Molekula is a new niche chemical company in Europe. purchase now cheap clarinex australia
Patients treated with Clozaril had a statistically significant longer delay in the time to recurrent suicidal behavior in comparison with olanzapine. This result should be interpreted only as evidence of the effectiveness of Clozaril in delaying time to recurrent suicidal behavior and not a demonstration of the superior efficacy of Clozaril over olanzapine. The cumulative incidence is estimated at 1% to 2% after one year of use. The onset is generally between 4 to 16 weeks following initiation of therapy, and it is usually reversible if detected early and the drug discontinued promptly. Bess AL, Cunningham SR. Dear health care professional letter regarding class labeling for atypical antipsychotics and risk of hyperglycemia and diabetes. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2004 Apr 1. From the FDA website. Holt RI. Consensus development conference on antipsychotic drugs and obesity and diabetes: response to consensus statement. Diabetes Care. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Lieberman JA, Yunis J, Egea E et al. HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia. Arch Gen Psychiatry. Based on Clozaril National Registry US patients data collected up to April 1995, a hematologic risk analysis found the incidence of agranulocytosis rises steeply during the first 2 months, peaks at approximately the third month, and decreases at 6 months of therapy; after 6 months the incidence decreases further, however, it never reaches zero. Crome P. Poisoning due to tricyclic antidepressant overdosage: clinical presentation and treatment. Med Toxicol.
Manufacturers recommend clinical monitoring of weight during therapy. 1 395 400 406 See Hyperglycemia and Diabetes Mellitus under Cautions. See Tables 1 and 2 for ANC monitoring frequency and treatment recommendations based on ANC value in the general patient population and for patients with BEN, respectively. Clozaril treatment. In clinical trials, approximately 1% of patients developed eosinophilia. Clozapine-related eosinophilia usually occurs during the first month of treatment. In some patients, it has been associated with myocarditis, pancreatitis, hepatitis, colitis, and nephritis. Such organ involvement could be consistent with a drug reaction with eosinophilia and systemic symptoms syndrome DRESS also known as drug induced hypersensitivity syndrome DIHS. If eosinophilia develops during Clozaril treatment, evaluate promptly for signs and symptoms of systemic reactions, such as rash or other allergic symptoms, myocarditis, or other organ-specific disease associated with eosinophilia. If Clozaril-related systemic disease is suspected, discontinue Clozaril immediately. Distributed into milk. 1 395 406 Discontinue nursing or the drug. Psychiatry 13 1: 27-35. Oro Valley, AZ 85755. November 17, 2015. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. pyridium pills purchase online store
Skin and Subcutaneous Tissue Disorders: Hypersensitivity reactions: photosensitivity, vasculitis, erythema multiforme, skin pigmentation disorder, and Stevens-Johnson Syndrome. People seem to do better when they receive both psychological and drug treatments. Reportedly present in low concentrations in placenta and may distribute into milk in animals; 2 not known whether crosses placenta in humans. 292 Distributed into milk in humans. Hartvig P, Eckernas SA, Lindstrom L et al. Receptor binding of N-methyl-11C clozapine in the brain of rhesus monkey studied by positron emission tomography PET. Psychopharmacology Berl. For the 956 patients who received clozapine or olanzapine in this study, there was extensive use of concomitant psychotropics: 84% with antipsychotics, 65% with anxiolytics, 53% with antidepressants, and 28% with mood stabilizers. There was significantly greater use of concomitant psychotropic medications among the patients in the olanzapine group. Clozapine Orally Disintegrating Tablets. Clozaril should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been determined. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Claas FHJ. Drug-induced agranulocytosis; review of possible mechanisms, and prospects for clozapine studies. Psychopharmacology. Cold JA, Wells BG, Froemming JH. Seizure activity associated with antipsychotic therapy. DICP. Potent CYP3A4 inducers: Concomitant use generally not recommended. 1 If concomitant use necessary, monitor for decreased efficacy of clozapine and consider increasing clozapine dosage.
Food and Drug Administration. Specific requirements on content and format of labeling for human prescription drugs; proposed addition of “geriatric use” subsection in the labeling; proposed rule. Fed Regist. Consider hematology consultation in patients with fever or neutropenia. Reviews John Wiley and Sons, Ltd. Celexa citalopram hydrobromide US prescribing information. Clozapine is approximately 97% bound to serum proteins. clomipramine
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Sperner-Unterweger B, Czeipek I, Gaggl S et al. Treatment of severe clozapine-induced neutropenia with granulocyte colony-stimulating factor G-CSF: remission despite continuous treatment with clozapine. Br J Psychiatry. Stimmel GL. Neuroleptics and the corpus striatum: clinical implications. Dis Nerv Syst. Undesirable alterations in lipids have occurred in patients treated with atypical antipsychotics, including Clozaril. Clinical monitoring, including baseline and periodic follow-up lipid evaluations in patients using Clozaril, is recommended. Drug dispensing should not ordinarily exceed a weekly supply. If a patient is eligible for ANC testing every 2 weeks, then a 2-week supply of Clozapine Orally Disintegrating Tablets can be dispensed. If a patient is eligible for ANC testing every 4 weeks, then a 4-week supply of Clozapine Orally Disintegrating Tablets can be dispensed. Dispensing should be contingent upon the ANC testing results. emis.info nolvadex
They demonstrated moderate-to-severe suicidal ideation with a depressive component within one week prior to their baseline evaluation. Sternberg DE. Neuroleptic malignant syndrome: the pendulum swings. Am J Psychiatr. Who should not take Clozaril? Immune System Disorders: Angioedema, leukocytoclastic vasculitis. If you are feeling depressed or experiencing any of the mentioned mental disturbances, talk to your doctor right away. There is likely a remedy that will make you feel better.
Bushe C, Leonard B. Association between atypical antipsychotic agents and type 2 diabetes: review of prospective clinical data. Br J Psychiatry Suppl. Ananth J, Johnson KM, Levander EM et al. Diabetic ketoacidosis, neuroleptic malignant syndrome, and myocardial infarction in a patient taking risperidone and lithium carbonate. J Clin Psychiatry. There is no known treatment for TD. However, the syndrome may remit partially or completely if treatment is discontinued. Antipsychotic treatment, itself, may suppress or partially suppress the signs and symptoms, and it has the potential to mask the underlying process. The effect of symptom suppression on the long-term course of TD is unknown. ventolin
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Sandoz Pharmaceuticals. Treatment systems requirements: Clozaril clozapine. East Hanover, NJ; 1991 Mar. Haring C, Meise U, Humpel C et al. Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and age. Psychopharmacology. Women receiving antipsychotic medication during pregnancy should consider undergoing early screening for gestational diabetes.


Let me introduce myself. My name is Ivana Horak. I am glad to offer you many interesting publications posted right here in my blog. I am a student, eager to learn and make discoveries from day to day. At present, I study foreign languages and practice my skills while translating useful and informative pages of experienced authors. Feel free to come and join me in my exciting journey!


So the other day I went to the gym….. it seems that this always occurs at the gym however it has happened at other public places as well. I see your eyes…. looking at me…. watching me….. you think that I don’t notice, but I do. I might be on an elliptical or weight machine….. I might just be walking from one area to another…. and you watch….. your eyes tell me that you are trying to figure out how I manage to do anything……..
Sometimes, I feel you staring……. I wonder what thoughts are going through your head….. I feel like walking up to you to let you know that I play guitar, I ride a motorcycle, I can tie my own shoes…….. but that would be rude.
Maybe I’m imagining that you are looking at my right arm but after being around for so many years, I think that I can tell the difference between a passing glance and a stare.
As a child, this would make me feel uncomfortable and I would often want to hide. As an adult, I get mad. In a society in which we are expected to be welcoming and tolerant of people from all backgrounds and cultures, why do I sometimes feel like I’m being isolated?
I sometimes want to walk up to you and tell you to take a picture. Perhaps I have done that to some of you. My mouth can often say things which perhaps should remain in my head, but when I feel these stares, I feel the need to prove myself.
As we age, there are certain aspects of our lives which remain with us until the end. Memories – good and bad. How we treated others and how we were treated. I don’t want to be seen as the person with 1 hand – I want to be seen as the person.
Those that know me see me as a whole person – some that see me in passing do not share this view.
I only share this in an effort to help you to understand how your eyes can make someone else feel. Your eyes can have an impact in someone’s day and life. Your eyes can be remembered or forgotten. Your eyes can take someone back to an uncomfortable time in their lives and make someone feel insecure and uncomfortable.
My days of wanting to hide are years behind me yet the anger that I feel when you look and judge me remains. Your eyes are one of the reasons why I share my story – so that when you next see me or someone like me, you see the whole person and treat us no differently than anyone else.
Would you feel comfortable asking me questions? I always encourage it but would you?
Until next time, thanks for reading!!


The Equity Unbound community welcomes you to join us in reflecting on Chimamanda Ngozi Adichie’s powerful TED talk entitled The danger of a single story. Our lives, our cultures, are composed of many overlapping stories. Novelist Chimamanda Adichie tells the story of how she found her authentic cultural voice — and warns that if we hear only a single story about another person or country, we risk a critical misunderstanding.
How can you join the #unboundeq conversation about The Danger of A Single Story?
- Watch the TED talk.
- Join our “slow chat” via twitter. Use the #unboundeq hashtag to respond to these three questions:
Question 1 (Q1):
In what ways are stories and narrative related to empathy & bias? #unboundeq
Question 2 (Q2):
Why do MANY stories matter? #unboundeq
Question 3 (Q3):
How are stories related to authenticity? And to power? #unboundeq


“Calamity is a great teacher,” observed Aisha Ahmad recently. Her response to the COVID-19 pandemic is true, but only if we are willing to learn the lessons available to us.
God uses pain to grab our attention.
“It is,” as C. S. Lewis wrote, “His megaphone to rouse a deaf world.” One of God’s cautionary signposts came when I asked our four children to list the lessons they have learned through this Coronavirus experience. My 5th-grade daughter Emma wrote, “I never realized how busy we were before.”
One day I was checking Outlook to plan for coming events, and the next day my schedule was forcibly purged, where seemingly immovable obligations were thrust into the abyss of an unknown future.
To lose control is never easy.
As I reevaluate my “life before COVID,” I have wrestled with God: “What are You trying to teach me?” His answer for me: “Pace yourself, John…”
For the first time in forever, I have had more time. Time to slow down…and just stop. Time to rest. Time to read. Time to be present. Time with the people who matter most. Time with the Author and Sustainer of time itself.
Despite all of the pain, loss, and heartache we’ve experienced in this surreal season, it has also become an unexpected gift. God has offered a collective reset for me.
God’s gifts of time and balance have always been there. But I was too busy to receive them before.
I don’t want to go back to normal.
I want to embrace the new normal that is as old as God’s original design for humanity.
May this great disruption become a great reset, a restorative reordering of the way things ought to be. The way the Grand Designer intended them to be all along.
Originally posted at ShelteringWings.org.


They say that the kitchen is the heart of the home. And we have to believe it’s true. Whether small or large, the kitchen is the hub of the home. It is where the meals are created – it fuels the bodies, minds and souls of friends and families all over the world. Some say that while life may be created in the bedroom, it is certainly lived in the kitchen. Much of the importance of this room seems to depend on the size and function of the kitchen, the family, and on lifestyle.


Each month Reader’s Digest navigate the woes and wonders of modern life, weighing in with leading experts on the everyday tools we need to survive and thrive in 2019.
Anna Walker speaks to doctor and author Philippa Kaye about the myths and taboos that surround the menopause as she releases her new book on the subject, The M Word.
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Ernest is poor but in some ways he was built to be poor. He was Spartan like in his wants, and comfortable even in discomfort of the a broken heater in a cold winter. He never ate out and never ate the expensive foods or wasted his money in the hole that's addiction. Ernest knew how to handle himself in a fight but it was a long time since he'd needed to use that experience. That excuse. Now He just read. His bookshelf was his nicest piece of furniture and his collection of book was his biggest source of pride. The bookshelf was fine mahogany and shined without dust, sitting in the place where most would put the source of familial gathering. Ernest like a man in penance had no family. Maybe it was out of penance that this solitudinous man lived with only slight fissures in his fortress of slight existence.
Monday, March 2, 2015
Ernest starts his day in pain. A slight uncomfortable pressure that comes from the throbbing of his head. A result of the chemicals at the paper mill, which he's labored in for the past decade. The pain at this point is a common greeting in the morning. He goes to his cupboard to get the large container of Aspirin. The bottle is the size normally reserved for alcoholics; the people who drink till they pass out then use the aspirin to recover for the night. Ernest doesn't drink often though he has friends at the factory who use the one bottle for the next. He however found no comforts or happiness in those corners.


Ph.D., German Literature, UW-Madison
I grew up in northern Minnesota near the shores of Lake Superior and the Boundary Waters. Some days I credit living near the end of I-35 for my unique perspective on Geography. In my free time, you will find me playing with my dogs, fixing my car, wandering the woods, or paddling my way through the BWCA.
I took a wanderer’s approach to my undergraduate education, which resulted in double majors in German Studies and American Indian Studies from the University of Minnesota in Duluth, as well as some great work experience in nursing and memory care. At the University of Wisconsin-Madison, I focused on Medieval German Literature at the master’s level and modern German literature and Second Language Acquisition at the doctoral level.
I like to see the world through new perspectives, and studying languages naturally gives me a window into a new worldview. I am also very interested in identity construction, and how language and culture interact as individuals develop and redevelop their own identities.
I am a strong proponent of education, and I believe that access to high quality education is vital for learners in their communities. I especially appreciate the access that distance education can provide to learners, regardless of their location or situation.


Rose-Line Brasset is a lady that I virtually met with couponing and now I consider her as a friend.
She wrote the nice série Juliette which touches a lot of readers all over the world!
These are great stories that make us travel without testing for COVID-19!
We will receive her at the beginning of April 2021 for the release of her new book!
Sylvain Paquin is a longtime friend and a visionary.
He works in Northern Quebec … When your address is on the Radisson road that says it all … It’s far from my small suburb …
You can visit it and do some really awesome tourism! A beautiful corner for the holidays! He has lots of wonderful photos so check out his Facebook page!
Katryne Parenteau is the FIRST AND ONLY female ice pilot in Canada! I feel priviledge to have this conversation!
Here she is with a boat captain. She’s the one who helps them navigate the ice!
I admit that I am impressed because she looks like a very soft and fragile little flower! It’s a decoy! She is strong and knows her job!
If I’m lucky she can show us around (virtually of course) the boat on which she sails!
Anne Fleishman is also an author that I met with OnMagasine.ca.
I am happy to invite her to OnMagasineExtra!
She writes detective novels and I love detective novels 🙂 So I will try to read it before I meet her! It is precisely the creation of a new one!
If you are interested here are his two books below.


Today the Devarenne Lab had a paper published in Biochimica et Biophysica Acta – Protein & Proteomics describing the identification and in vitro characterization of a new α-subunit of the tomato SnRK1 complex called SnRK1.2. The study characterizes the differences in kinase activity for SnKR1.2 as compared to the previously characterized α-subunit SnRK1.1. These studies were led by former graduate student Dongyin Su.
The Devarenne Lab recently had a paper published in Algal Research describing the isolation and characterization of the PSAP protein from the B race of B. braunii. PSAP is a highly glycosylated protein found in the extracellular matrix of B. braunii and it may play a role in the biosynthesis of the polysaccharide fibril sheath that surrounds the B. braunii colony. This study was lead by graduate student Mehmet Tatli and was a collaboration with the Complex Carbohydrate Research Center at the University of Georgia.
Today the Devarenne lab had a new paper published in Plant Direct about our continuing collaborative studies with the lab of Dr. Arum Han. This study features the development and implementation of an algal droplet microfluidics device that can perform high-throughput screens to analyze lipid and biomass production in order to identify mutants of interest from a large mutant population.
The Devarenne Lab recently had a paper published in ACS Chemical Biology describing the amino acids that control substrate and product specificity in the LOS enzyme from the L race of B. braunii. The study details how we identified two amino acids in LOS that control the size of substrate that can fit into the active site. The study was lead by former graduate student Hem Thapa.
The Devarenne lab had another paper published based on our collaboration with the lab of Dr. Edmundo Lozoya-Gloria at CINVESTAV in Irapuato, México. The study titled “ROS detection in Botryococcus braunii colonies with CellROX Green reagent” was published in Bio-Protocol and describes the method Dr. Lozoya-Gloria’s lab developed to detect ROS production in B. braunii.


eyeballsarchive replied to your post“putnamspuppeteer asked pnattheories: If Max isn’t possessed, then…”Yo dude, Doorman never says that’s the power of the spirit controlling Max? I mean yeah “Arrogance. Your power is nothing to be afraid of. Riddles and word games.” could be interpreted as meaning that that was the spirit in question’s power, but that’s not how it should be interpreted.But he also says their power is “riddles and wordgames”, and Scrapdragon seems to just have magnet powers, especially considering that spirit connection thing had a lot of metal in it, and the others we’ve seen seem to be similar to a spirit’s powersWhat Doorman is doing is calling what Scrapdragon is saying in that circumstance “riddles and word games”.I mean I could be wrong? I was in the “Max has timestop powers” camp until chapter 3, page 17, but after that I held firmly onto magnet powers until it was revealed clearly to be true. I’m not going to change my mind until the story itself proves me wrong.Anyway as I said, it doesn’t feel right in the context of the story that Max would have two spirits. Both of Spender’s spirits are present in his mindscape on this page, but Scrapdragon is alone in his first and so far only full appearance.
But apparently the riddles are something to be protected from. I don’t think it works as evidence to say how it should be interpreted, since neither of us know for sure. But you’re definitely right on there only being Scrapdragon in the connection, sorry I missed that. (Is the possibility of it being something that just possessed him for the moment out of the question?)


According to recent studies, China is projected to become the world’s largest economy by 2030, so the demand for high-quality language solutions is unlikely to wane in the near future.
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From the gloomy corridors of decaying castles to the spectral presences that haunt them, this comprehensive guide uncovers the shrouded mysteries of Gothic literature, art, and culture. Beginning with the genre’s birth in the late 18th century, the article delves into Gothic’s evolution, exploring its most prominent elements such as the supernatural, the damsel in distress, the anti-hero, and an atmosphere teeming with suspense.
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A band is many things as an entity. It’s equal parts love, with hate, tonic, and a pinch of volatile subtlety. From the outsiders perspective, there’s a sense of grandeur, but when you sift through the cracks and get inside, the intricacies can be overwhelming. It’s tough. It’s fun.
Four personalities. Four thousand ideas. Four history’s. With this, figuring out a unified direction can have it’s ups and downs. Funny thing is, once you think you’ve figured out what direction you’re moving, you blink, and you’re going somewhere else entirely.
It all starts individually you know? Each individual wanting something more from ourselves, more from the world that surrounds us. Add onto that, being young and restless, and you get forward momentum. Watch it as the aspirations take on a life of their own, and all of a sudden it’s not you. It’s everything around you. It’s sacrifice. It’s expectation. It’s perception. It’s peace of mind.
Things that go unsaid often have a violent potential, but you breathe, and try to find a way to explain. Yet, things needing to be heard will fall on deaf ears. Eventually. It’s in these times the trick is to find a way to grit your teeth, and sacrifice what you need for the greater good of something we all believe in. Channel it right? Take our own advice and use it as motivation? Certainly. Left foot, right foot, left foot, right foot, drop.
It can be so absurd 🙂