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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | More data on endogenous sex hormones need to be collected from further large prospective studies after a long follow-up period, but the evidence that endogenous oestradiol concentration is related to breast cancer risk in post-menopausal women is becoming strong. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | BVAS score also improved after treatment, however, persistent ENT symptoms were scored as disease activity and it is worth considering the difficulty in clinically distinguishing between active disease and tissue damage and therefore BVAS may in fact over emphasize extent of disease activity after RTX. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | no discussion section |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In six of the PPA subjects, however, the magnitude of this effect was beyond the range seen in the control group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further supporting the role for local TNF expression, it was shown that TNF inhibitors demonstrate efficacy in a subset of patients with FSGS enrolled in the FONT Study (14, 42) in the absence of evidence of elevated serum TNF levels in these patients. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In case of contraindications for anticoagulation, physical measures should be used (e.g., medical compression stockings). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There are some limitations to consider when translating the current videofluorographic findings in the rat to standard videofluorography in humans. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Reduction of uncertainty is a variable that changes monotonically with the discount factor: the smaller the γ, the less dependence of the value of each strategy on uncertain cached values on the leaves and therefore, the more reduction of uncertainty by deepening the tree. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The aim of this study was to focus on the under-investigated aspect of personal religious factors, especially prayer, in the pain management of West-European CP patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A genetic risk score that included 10 variants detected in GWAS of AD but excluded APOE ε 4 was also marginally associated with a compound test score for memory in 5,171 non-demented persons from the population-based Rotterdam Study (mean age 66.2 years) [Verhaaren et al 2013], and a genetic risk score constructed from 22 AD-associated loci was associated with significantly faster decline in a composite memory score in 7,172 non-Hispanic white (mean age 63.0 years) but not in 1,081 non-Hispanic black participants (mean age 61.6 years) in the nationally representative Health and Retirement Study [Marden et al 2016]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Other limitations include: 1) possible extra-adrenal effects of KTCZ; however, exogenous cortisol normalized ACTH concentrations otherwise stimulated by KTCZ administration; 2) possible diurnal or seasonal effects (26, 40); 3) unknown effects of CBG per se on feedback by cortisol; and 4) uncertainty regarding long-term gonadal-steroid effects on HPA axis regulation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Quality of life itself is not a pre-determined characteristic – it can be modified if public health specialists target appropriate interventions at specific groups of people. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Higher rates of visual impairment have been reported among persons aged 12 and above among Hispanics and Blacks compared to Caucasians 24. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To date, no human feeding trials are available to discuss the effect of walnut consumption on the Firmicutes/Bacteroidetes ratio. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The temporal relationship between exposure and outcome cannot be ascertained in a cross-sectional analysis; however, undiagnosed cardiovascular risk factors are unlikely to impact on the physical food environment or eating patterns. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Clinically significant central nervous system or respiratory depression attributed to epidural analgesia can be avoided by slow titration, careful monitoring of sedation levels and respiratory status, and reduction of the opioid dose when sedation increases. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our morphological findings, for both STR and LMC mice, most closely resemble observations by Gibb and Kolb (Gibb & Kolb, 2005) of significantly increased overall, parietal cortical thickness. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With 26 weeks of randomized continuation treatment, the duration of the phase referring to the confirmatory hypothesis test is consistent with Kupfer’s (1991) widely accepted model of the long-term course of depression as well as with findings from trials investigating the optimal length of continuation therapy (Prien and Kupfer, 1986; Reimherr, Amsterdam, Quitkin, Rosenbaum, Fava, Zajecka, Beasley, Michelson, Roback and Sundell, 1998), so that the efficacy of WS® 5570 in preventing relapse can be validly assessed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The resulting data strongly confirm the previously reported association between endogenous oestradiol and breast cancer risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the present study adds to other evidence from LMICs [35,37,48] that car ownership appears to negate any effect of walkable neighborhood design on active commuting. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the study of AKT1 single polymorphism, rs2494732 wasn’t detected the association with CHD, either genotypes or alleles. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We found a higher density of fruit and vegetable vendors was associated with a decrease in blood pressure. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | More human intervention trials investigating different servings of nuts over a longer time period might be useful to further evaluate the prebiotic properties of walnut consumption. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This is the first report involving the impact of oxygen concentration on human pre-compaction embryos using a prospective randomized sibling-oocyte study model in a Chinese population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | More marked hypovitaminosis D leads to the accumulation of osteoid and the mineralisation defect characteristic of osteomalacia. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Careful deep rasping of the greater trochanter is the key to avoiding cortical-bone damage. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For example, we found that higher density of highly processed and take-away food vendors within 400 m buffer, but not 1600 m buffer or distance to nearest vendor, was associated with increased BMI and waist circumference. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The findings in this study were consistent with those in a previous study that reported fatalist attitudes are prevalent and fear of cancer is frequent among those who live in lower socioeconomic conditions (Byrne, 2009). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We have identified four distinct BMIz trajectories in the first 2 years of life in a multi-ethnic cohort of Asian children. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Similarly, it would be interesting to determine whether circulating autoantibodies including anti-CD40 (46) or cytokine receptor–like factor-1 (CRLF-1) (47), which are linked to proteinuria in FSGS, may cause TNF-mediated podocyte injury. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Using data from the KYRBWS-VI, this study was cross-sectional in design; thus, it examined the interrelationship between stress and atopic dermatitis rather than issues of causality. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings provide evidence that both duration (reflected by stable high BMIz and stable low BMIz trajectories) and age of onset (reflected by rapid BMIz gain trajectory) of excess adiposity may be important factors in predicting subsequent cardio-metabolic risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | MtF individuals appeared more affected than FtMs on three other scales: Hypochondriasis, Depression and Hysteria. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The prevalence of tooth size discrepancy in this study was 20% in males and 28% in females for overall ratio and 40% in males and 46% in females for anterior ratio. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, many other postnatal factors, such as parenting style and exposure to adverse environment, which were not assessed in our study, may also confound the findings. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | That method is simple and straightforward to implement, while LCGMM is relatively computer-intensive. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Here, we employed the global dynamic compliance and regional EIT to guide intraoperative PEEP selection. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a study, Hong et al. reported an association of ACE gene I/D polymorphism with primary knee osteoarthritis in a homogeneous Korean population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, angiogenin could be involved in the host response to inflammatory processes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Reported inhibition studies using rabbit anti-sera have demonstrated that polymerization did not produce new antigenic determinants [16,22]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The more granular neuropsychological assessment of progesterone's purported neuroprotective properties did not reveal a significant effect, and the findings were concordant with the GOSE primary outcome. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, when hysterectomy is performed 4 weeks after conization, laparoscopy is preferred, with lower rates of postoperative infection and complications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Routine drainage was also associated with no benefit in the postoperative period. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Neither CAC nor PIC, however, are currently well defined. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The explanation might be the following: as uterine arteries and ligaments close to the cervix were mainly managed by electrosurgery in laparoscopic hysterectomy, inflammatory hyperemia around the cervix would reach its peak approximately 1–2 weeks after conization, resulting in more coagulation and hemostasis from hysterectomy using bipolar electrosurgery during this period, with thermal radiation burns affecting the function of surrounding tissues [22–25]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The negative predictive value of C. trachomatis MIF was high (98%), which correlates with another serological study that showed a high negative predictive value for C. trachomatis enzyme immunoassay 6. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although the participants who were ≥40 years old had more information about breast cancer, the benefit perception of BSE, health motivation and self-efficacy perception were lower in this age group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Participants in Oxford House share their background, discuss drug histories, talk about personal and group goals, eat together, engage in chores, and attend 12-step meetings and go on other outings with one another (Olson et al, 2005). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, when hysterectomy was performed 4–6 weeks after conization, the postoperative infection rates, severity of infection, grade and days of using antibiotics, and inflammatory cell infiltration decreased significantly, with no postoperative bleeding and fewer complications. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Once a dose has been reduced because of toxicity, dose escalation in the subsequent cycles is not recommended. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additional studies are needed to investigate the role of TNF- or NFAT-mediated dysregulation of cholesterol homeostasis in the context of nonglomerular diseases. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Also, reduction was a common goal in our study and predicted a greater probability of a quit attempt and a decrease in problems or dependence. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Third, we describe for the first time to our knowledge the opposing roles of free (proapoptotic) and esterified cholesterol (antiapoptotic) as key mediators of TNF-induced podocyte injury. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study also demonstrates that it is important to test for both IgG and IgM antibodies to optimize the likelihood of detecting a serologic response. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our unacceptable 6.5% rate of fractures of the greater trochanter during operation was mainly due to the early experience of both surgeons with the technically demanding stem implantation technique. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | al targeted customers visiting pharmacies [11]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the last decades, many researchers aimed to identify causal genetic variants by means of candidate gene analyses, Genetic research is done to identify underlying causative genes and pathways, and thereby understand more about the biology of the disease with potential implications for development of novel treatments, and to be able to predict risk of disease by genotyping the identified risk alleles [23]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, patients with and without CKD both had higher BP control in the TI group vs. UC group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, we showed that CD133+CD44+CD54+ subpopulation of CTCs has a prognostic value in CRC with liver metastasis, and has a significant effect on the survival of CRC patients who did not undergo surgical treatment for metastasis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A beneficial effect of daytime napping for stroke and its subtypes was shown in our research. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We were unable to establish the positive predictive value of our screening efforts because of non-compliant follow-through for a professional evaluation among those identified for referral and the design of the study was not intended to provide formal ophthalmologic examination to all participants. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Endothelial NO synthase gene genetic variant is also detected to contribute to the risk of sporadic CHD[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We did not find an association between breastfeeding and the BMIz trajectories, consistent with earlier studies by Pryor et al14, Giles et al17 and Garden et al43. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | CR1 (rs3818361) [Hollingworth et al 2011] was associated with more rapid decline on the DSST in the same study, while PICALM (rs3851179 and rs541458 [Harold et al 2009] was associated with an earlier age at midpoint of decline of the 3MS [Sweet et al 2012]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This is lower than US population screening rates (12.7%).8 Given the high prevalence of HCV among people with SMI,2,9 this finding represents a significant public health concern. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A hyperinflammatory response arises in some patients, resulting in a cytokine storm and dramatic changes in coagulation tests, including elevated D-dimers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We have expanded upon previous studies examining the relationship between seminal plasma HIV-1 RNA level and seminal plasma cytokines by controlling for blood plasma HIV-1 RNA level in our model. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further study of TB in natural populations, in conjunction with the development of superior diagnostic methods and laboratory studies, would provide further valuable insights into this relatively under-studied, and potentially zoonotic, disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Buffering with bicarbonate lowers renal oxygen consumption and reduces the amount of free oxygen radicals. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Most importantly, a significant difference in SF angiogenin concentrations was found between inflammatory and noninflammatory joint diseases. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These reports and our findings suggest that DICER1 rs3742330 may impact the regulation of DICER1 expression, even if it shows a tumor-specific pattern, which requires laboratory-based functional studies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Because all the FtMs reported an early onset and almost all of them reported a same biological sex orientation, no comparisons could be made on this basis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The reason is low percentage of ethnic minority groups in general population in Georgia19 as well as among PLWHIV (6%) (Georgian AIDS Center Database). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additionally, in clinical settings where therapeutic drug monitoring is routine, a population pharmacokinetic model constructed using morphomic measures would likely only modestly improve empirical dosing due to the significant residual variability in our population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this clinical trial, we set FiO2 as 3, which was adequate to maintain the intraoperative oxygen supply and consumption balance, with no signs of decreased SpO2, ScvO2, or rSO2. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | If more than two dose reductions are necessary, treatment discontinuation should be considered7. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, there is no rule concerning the optimal timing of surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Addressing absenteeism, ensuring that patients are aware of their rights to free essential drugs and services, and extending government subsidies to the dispensation of more drugs and ancillary care will improve both the quality and the uptake of public sector facilities closer to home, and reduce costs and delays for patients [28, 41]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The widespread dispersal of spores in a building has been demonstrated both by Q fever (disseminated through a large medical school building) (23) and by anthrax (dispersed through a post office with an area of 281,387 ft2 and a volume of approximately 7 million ft3) (40). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Both high and low ABI are predictors for cardiovascular mortality. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study also evaluated relationships between objective (SOT and LOS) and subjective (DHI) measurements. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, this study has limitations that must be considered when interpreting our findings. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, this study was conducted with a relatively large population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These alternative expressions of weight are designed to approximate fat-free mass, although only LBW was determined experimentally using bioelectrical impedance and dual-energy X-ray absorptiometry (DEXA) (10). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Previous studies have successfully validated the roles of MC1R (38), CDKN2A (39), TERT (40) and ARNT/ SETDB1 (41) in melanoma disease risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such a difference can be a result of several factors: the type of surgery (open vs. laparoscopic), demographic parameters, stage of cancer, etc. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | HLA genes in association with the gut microbiome may determine the immune environment and confer susceptibility to autoimmune arthritis (18). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Mutations in OCA2 are known to cause oculocutaneous albinism type 2; however, the gene is also known to play a role in normal pigmentation variation and is associated with blue irises in European populations (42). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, rs3742330 may either directly or indirectly alter Dicer-mediated miRNA levels, which can influence mRNA transcription and CRC risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Contextual skills of all four eating competence subcomponents were most strongly associated with metabolic risk factors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In centers that routinely perform this procedure laparoscopically, the number of lymph nodes harvested and the R0 resection rate are comparable [10,19,20]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, those studies used relatively low doses of remifentanil, which may have limited its influence on OIH. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Over the years, practice at St. Jude has changed so that TCAs are prescribed for NP as a second-line therapy after the maximum dose of gabapentin has been tried. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, abdominal hysterectomy performed with the cold knife procedure causes relatively little damage to the surrounding tissues. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further studies may still be needed to explore whether injecting an antibiotic in a pregnant woman with an increased NLR may reduce various neonatal complications and various sequelae of neonates accompanying histologic chorioamnionitis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Q fever is also a recognized occupational disease in the United Kingdom (45) and governed by existing legislation (46), although it is not a notifiable disease (47). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As a possible mechanism for the reduced pain after robotic hysterectomy, Chiu et al[17] explain that the chance of using the abdominal wall for leverage is decreased because the robotic arms pivot at the port sites and move/rotate around a fixed remote center-of-motion, thereby decreasing mechanical injury at the abdominal wall. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Only retrospective data exist in this setting, and few of these studies provide an appropriate control group for comparison. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Cremation forms must be completed by medical staff to prevent the inappropriate cremation of pacemakers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, beliefs in Specific-Concern was not significantly associated with self-medication and total QAQ score although it was considered as one of the negative beliefs. |