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A1BG, Official Symbol A1BGprovided by HGNC Official Full Name alpha-1-B glycoproteinprovided by HGNC Primary source HGNC:HGNC:5 See related Ensembl:ENSG00000121410 MIM:138670; AllianceGenome:HGNC:5 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1B; ABG; GAB; HYST2477 Summary The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008] Orthologs mouse all In the passage above, the pronoun "it" refers to A1BG. True or false?

False

A1BG-AS1, Official Symbol A1BG-AS1provided by HGNC Official Full Name A1BG antisense RNA 1provided by HGNC Primary source HGNC:HGNC:37133 See related Ensembl:ENSG00000268895 AllianceGenome:HGNC:37133 Gene type ncRNA RefSeq status PREDICTED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A1BGAS; A1BG-AS; NCRNA00181 Expression Biased expression in liver (RPKM 106.5) and spleen (RPKM 1.9) See more In the passage above, the pronoun "it" refers to A1BG-AS1. True or false?

True

A1CF, Official Symbol A1CFprovided by HGNC Official Full Name APOBEC1 complementation factorprovided by HGNC Primary source HGNC:HGNC:24086 See related Ensembl:ENSG00000148584 MIM:618199; AllianceGenome:HGNC:24086 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as ACF; ASP; ACF64; ACF65; APOBEC1CF Summary Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] Expression Biased expression in liver (RPKM 31.2), small intestine (RPKM 8.6) and 4 other tissues See more Orthologs mouse all In the passage above, the pronoun "it" refers to A1CF. True or false?

True

A2M, Official Symbol A2Mprovided by HGNC Official Full Name alpha-2-macroglobulinprovided by HGNC Primary source HGNC:HGNC:7 See related Ensembl:ENSG00000175899 MIM:103950; AllianceGenome:HGNC:7 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A2MD; CPAMD5; FWP007; S863-7 Summary The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016] Expression Broad expression in lung (RPKM 732.0), urinary bladder (RPKM 374.7) and 21 other tissues See more Orthologs all In the previous sentence, can the pronoun "this" be replaced with "A2M"? Yes or no?

Yes

A2M-AS1, Official Symbol A2M-AS1provided by HGNC Official Full Name A2M antisense RNA 1provided by HGNC Primary source HGNC:HGNC:27057 See related Ensembl:ENSG00000245105 AllianceGenome:HGNC:27057 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Expression Broad expression in lung (RPKM 20.8), liver (RPKM 9.6) and 21 other tissues See more In the previous sentence, does the pronoun "it" refer to A2M-AS1? Yes or no?

Yes

A2ML1, Official Symbol A2ML1provided by HGNC Official Full Name alpha-2-macroglobulin like 1provided by HGNC Primary source HGNC:HGNC:23336 See related Ensembl:ENSG00000166535 MIM:610627; AllianceGenome:HGNC:23336 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as OMS; p170; CPAMD9 Summary This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] Expression Restricted expression toward esophagus (RPKM 190.0) See more Orthologs all In the passage above, the pronoun "it" refers to the A2ML1. True or false?

True

A2ML1-AS1, Official Symbol A2ML1-AS1provided by HGNC Official Full Name A2ML1 antisense RNA 1provided by HGNC Primary source HGNC:HGNC:41022 See related AllianceGenome:HGNC:41022 Gene type ncRNA RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Annotation information not in current annotation release Question: Who or what is "their"? Is it HGNC? Answer:

No

A2MP1, Official Symbol A2MP1provided by HGNC Official Full Name alpha-2-macroglobulin pseudogene 1provided by HGNC Primary source HGNC:HGNC:8 See related Ensembl:ENSG00000291190 AllianceGenome:HGNC:8 Gene type pseudo RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as A2MP Expression Biased expression in adrenal (RPKM 1.1), spleen (RPKM 0.5) and 11 other tissues See more In the previous sentence, does the pronoun "it" refer to A2MP1? Yes or no?

Yes

A3GALT2, Official Symbol A3GALT2provided by HGNC Official Full Name alpha 1,3-galactosyltransferase 2provided by HGNC Primary source HGNC:HGNC:30005 See related Ensembl:ENSG00000184389 MIM:619850; AllianceGenome:HGNC:30005 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as IGB3S; IGBS3S; A3GALT2P Summary Predicted to enable N-acetyllactosaminide 3-alpha-galactosyltransferase activity and alpha-1,3-galactosyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to act upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and vesicle. [provided by Alliance of Genome Resources, Apr 2022] Expression Low expression observed in reference dataset See more Orthologs mouse all Question: Who or what is "it"? Is it A3GALT2?

No

A4GALT, Official Symbol A4GALTprovided by HGNC Official Full Name alpha 1,4-galactosyltransferase (P blood group)provided by HGNC Primary source HGNC:HGNC:18149 See related Ensembl:ENSG00000128274 MIM:607922; AllianceGenome:HGNC:18149 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as P1; PK; Gb3S; P(k); P1PK; A14GALT; A4GALT1 Summary The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in kidney (RPKM 6.5), fat (RPKM 5.5) and 22 other tissues See more Orthologs mouse all In the passage above, the pronoun "this" refers to A4GALT. True or false?

True