{"id":"4620","tokens":["These","findings",",","therefore",",","could","have","clinical","significance","to","AIDS","patients","with","malignancies","who","are","undergoing","radiotherapy","and","chemotherapy","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3065","tokens":["Furthermore",",","GR","number","failed","to","normalize","after","incubation","in","media","alone","or","IL-2","and","IL-4","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"994","tokens":["This","suggests","that","in","these","cells","GR","within","the","nucleus","interacts","with","cytokine-stimulated","transcription","factors","by","the","process","of","cross","coupling","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"10269","tokens":["B-cell","chronic","lymphocytic","leukemia","(","B-CLL",")","cells","accumulate","in","vivo","in","the","G0\/G1","phase","of","the","cell","cycle",",","suggesting","that","their","malignant","expansion","is","due",",","at","least","in","part",",","to","a","delay","in","cell","death","."],"ner_tags":[5,6,6,6,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13013","tokens":["Down-regulation","of","17beta-HSD","IV","mRNA","expression","was","associated","with","enhanced","estradiol","inactivation","by","U937","cells",",","suggesting","a","link","between","estrogenic","pathways","and","cell","proliferation","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14851","tokens":["In","this","report",",","we","show","that","upon","the","stimulation","of","both","pathways","T","lymphocytes","became","refractory","to","activation","via","the","CD3\/T","cell","receptor","(","TcR",")","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,9,10,10,0,9,0,0,0]}
{"id":"5490","tokens":["Tax","does","not","bind","directly","to","DNA","but","rather","deregulates","the","activity","of","cellular","transcription","factors","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"10635","tokens":["We","have","examined","the","effect","of","cytokines","on","IL-2","deprivation-induced","apoptosis","of","human","antigen-specific","T","helper","clones","with","different","cytokine","production","profiles","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,5,6,6,6,6,0,0,9,0,0,0]}
{"id":"11273","tokens":["These","studies","examined","the","ability","of","CMV","IE","gene","products","to","modulate","IL-6","production","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"7951","tokens":["The","effect","of","Dex","was","completely","reversed","by","a","glucocorticoid","receptor","antagonist",",","RU38486","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"7937","tokens":["Molecular","mechanisms","of","neutrophil-endothelial","cell","adhesion","induced","by","redox","imbalance","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9398","tokens":["Recently",",","cyclin","E-Cdk2-","and","cyclin","A-Cdk2-dependent","phosphorylation","of","a","single","conserved","serine","residue","(","Ser5",")","in","Id2","has","been","shown","to","occur","during","late","G1-to-S","phase","transition","of","the","cell","cycle",",","and","this","neutralizes","the","function","of","Id2","in","abrogating","E-box-dependent","bHLH","homo","-or","heterodimer","complex","formation","in","vitro","(","E.Hara",",","M.Hall",",","and","G.Peters",",","EMBO","J.16",":","332-342",",","1997",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1472","tokens":["Conversely",",","genistein",",","another","tyrosine","kinase","inhibitor",",","totally","abolished","the","expression","of","the","second","peak","of","junB","mRNA","whereas","it","did","not","affect","the","expression","of","the","first","peak","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9874","tokens":["METHODS","AND","RESULTS",":","We","measured","levels","of","TF","activity","in","peripheral","blood","mononuclear","cells","and","highly","purified","monocytes\/macrophages","from","10","consecutive","cardiac","transplant","recipients","and","10","healthy","control","subjects","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,7,8,8,8,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18031","tokens":["The","survival-promoting","activity","of","the","Bcl-2","family","of","proteins","appears","to","be","modulated","by","interactions","between","various","cellular","proteins","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"10208","tokens":["A","1-kb","region","of","the","gene","that","includes","5","'","flanking","sequence","was","reported","earlier","to","contain","functional","promoter","activity","and","was","specifically","demethylated","in","expressing","cells","in","contrast","to","null","cells","."],"ner_tags":[0,1,2,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,7,8,0]}
{"id":"4922","tokens":["We","have","previously","identified","a","new","transcription","factor","family","(","the","MNP","family",")","whose","expression","is","crucial","for","the","induction","of","MIP-1","alpha","transcription","during","cellular","activation","and","in","transformed","B","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,5,6,6,0]}
{"id":"9892","tokens":["Unlike","Oct-1",",","which","is","constitutively","expressed","in","many","cell","types",",","Oct-2","expression","is","restricted","primarily","to","B","lymphocytes","and","can","be","induced","in","precursor","B","cells","by","stimulation","with","bacterial","lipopolysaccharide","(","LPS",")","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,8,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0]}
{"id":"5390","tokens":["In","promoter","regions",",","the","actively","transcribed","genes","demonstrated","extensive","and","consistent","footprints","over","the","canonical","elements",",","such","as","CACCC","and","CCAAT","motifs","."],"ner_tags":[0,1,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"2053","tokens":["Tenascin","(","TN",")","is","an","extracellular","matrix","protein","that","is","expressed","widely","in","the","fetus","and","sparingly","in","the","adult",",","but","reappears","at","high","levels","in","certain","areas","of","tissue","insult","such","as","tumor","matrices","and","sites","of","wound","healing","."],"ner_tags":[9,0,9,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17823","tokens":["B-lymphoblastoid","cell","lines","from","multiple","sclerosis","patients","and","a","healthy","control","producing","a","putative","new","human","retrovirus","and","Epstein-Barr","virus","."],"ner_tags":[5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17414","tokens":["The","internal","methionine","codons","of","human","T-cell","leukemia","virus","type","II","rex","gene","are","not","required","for","p24rex","production","or","virus","replication","and","transformation","."],"ner_tags":[0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"7036","tokens":["The","purpose","of","this","study","was","to","evaluate","whether","the","mitogen-activated","protein","kinase","(","MAPK",")","signaling","pathway","contributes","to","12-O-tetradecanoylphorbol-13-acetate","(","TPA",")","-induced","mononuclear","differentiation","in","the","human","myeloblastic","leukemia","ML-1","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,0]}
{"id":"2877","tokens":["Description","and","functional","implications","of","a","novel","mutation","in","the","sex-determining","gene","SRY","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,1,0]}
{"id":"14068","tokens":["The","T\/NK","subsets","in","the","BM","of","MRD-negative","(","MRD-",")","LT","(","MRD-\/LT",")","patients","showed","similar","numbers","of","cells","as","normal","volunteers","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5297","tokens":["The","transcriptional","activity","of","both","domains","is","strongly","potentiated","by","interactions","with","distinct","B","cell-specific","coactivators","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"3480","tokens":["The","other","glucocorticoids","tested",",","methylprednisolone","and","corticosterone",",","were","also","effective","at","concentrations","of","10","(","-5",")","M","or","greater","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15331","tokens":["Human","T","cell","activation","through","the","activation-inducer","molecule\/CD69","enhances","the","activity","of","transcription","factor","AP-1","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,9,10,10,0]}
{"id":"17830","tokens":["Whether","the","putative","new","retrovirus","(","es",")","and","EBV","have","any","causal","relationship","to","MS","is","still","not","known",",","but","the","findings","support","this","possibility","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8239","tokens":["When","HL60","cells","or","normal","myeloid","progenitor","cells","were","exposed","to","exogenous","E1","they","became","more","sensitive","to","the","differentiation-inducing","effects","of","D3","."],"ner_tags":[0,5,6,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"285","tokens":["CIITA","is","a","class","II","gene","transactivator","known","to","be","defective","in","one","form","of","BLS","and","to","be","required","for","the","induction","of","MHC","class","II","by","IFN-gamma","."],"ner_tags":[1,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0]}
{"id":"5569","tokens":["MHC","class","II","density","on","the","APC","was","modified","using","DQ2","homo","-and","heterozygous","B-LCLs","as","APCs",",","however","this","variation","of","MHC","concentration","had","no","effect","on","T","cell","proliferation","."],"ner_tags":[9,10,10,0,0,0,7,0,0,0,5,6,6,6,6,0,7,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0]}
{"id":"15546","tokens":["We","show","that","induction","of","a","trimer","of","the","NFAT","and","Oct","sites","is","not","sensitive","to","phorbol","ester","treatment",",","and","that","mutations","in","the","NF-kappa","B","site","have","no","effect","on","inducibility","of","the","IL-2","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,1,2,0]}
{"id":"5196","tokens":["An","element","upstream","from","the","human","delta-globin-encoding","gene","specifically","enhances","beta-globin","reporter","gene","expression","in","murine","erythroleukemia","cells","."],"ner_tags":[0,1,0,0,0,1,2,2,0,0,1,2,2,0,0,7,8,8,0]}
{"id":"17357","tokens":["Interferon-gamma","and","the","sexual","dimorphism","of","autoimmunity","."],"ner_tags":[9,0,0,0,0,0,0,0]}
{"id":"15325","tokens":["In","GH4C1","pituitary","cells",",","T3SO4","failed","to","displace","[","125I","]","T3","from","nuclear","receptors","in","intact","cells","or","soluble","preparations","."],"ner_tags":[0,5,6,6,0,0,0,0,0,0,0,0,0,0,9,10,0,5,6,0,0,0,0]}
{"id":"14347","tokens":["A","new","approach","to","facilitate","immobilization","and","affinity","purification","of","recombinant","proteins","and","selected","human","B","lymphocytes","has","been","developed","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,7,8,8,0,0,0,0]}
{"id":"1100","tokens":["To","limit","expression","of","a","transduced","HIV-1","long","terminal","repeat","(","LTR",")","-IFNA2","(","the","new","approved","nomenclature","for","IFN","genes","is","used","throughout","this","article",")","hybrid","gene","to","the","HIV-1-infected","cells",",","HIV-1","LTR","was","modified","."],"ner_tags":[0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0,0,1,2,0,0,0,0,0,0,1,2,0,0,5,6,0,1,2,0,0,0]}
{"id":"6579","tokens":["The","transcription","factor","NF-ATc","that","controls","gene","expression","in","T","lymphocytes","and","embryonic","cardiac","cells","is","expressed","in","three","prominent","isoforms","."],"ner_tags":[0,9,10,9,0,0,0,0,0,7,8,0,7,8,8,0,0,0,0,0,0,0]}
{"id":"2856","tokens":["Hence",",","the","PRL","-induced","biphasic","expression","of","the","IRF-1","gene","appears","to","be","controlled","by","separate","PRL-responsive","elements",":","elements","in","the","first","0.2","kb","of","the","IRF-1","promoter","region","act","during","early","activation",",","and","elements","between","0.2","and","1.7","kb","act","in","concert","with","the","proximal","0.2-kb","region","during","S","phase","progression","."],"ner_tags":[0,0,0,9,0,0,0,0,0,1,2,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8562","tokens":["Using","mitogen","stimulated","and","quiescent","peripheral","blood","mononuclear","cells","(","PBMC",")","and","Jurkat","cells",",","we","compared","differences","in","basal","transcription","and","amounts","and","binding","of","transcription","factors","with","TRE-1","."],"ner_tags":[0,0,0,0,0,7,8,8,8,0,7,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,1,0]}
{"id":"2321","tokens":["(","ABSTRACT","TRUNCATED","AT","250","WORDS",")"],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"18520","tokens":["A","regulatory","element","in","the","human","interleukin","2","gene","promoter","is","a","binding","site","for","the","zinc","finger","proteins","Sp1","and","EGR-1","."],"ner_tags":[0,1,2,0,0,1,2,2,2,2,0,0,1,2,0,0,9,10,10,9,0,9,0]}
{"id":"11175","tokens":["HIV","does","not","replicate","in","naive","CD4","T","cells","stimulated","with","CD3\/CD28","."],"ner_tags":[0,0,0,0,0,7,8,8,8,0,0,9,0]}
{"id":"9432","tokens":["A","survey","of","promoters","has","revealed","that","the","wild-type",",","unfused","EBNA3C","can","specifically","repress","expression","from","reporter","plasmids","containing","the","Epstein-Barr","virus","Cp","latency-associated","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,1,2,0,0,0,0,1,2,2,0]}
{"id":"7417","tokens":["Neighbouring","sequence","analysis","favours","a","small","deletion","model","of","slipped","mispairing","events","during","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13932","tokens":["The","concentration","of","c-fos",",","c-jun",",","c-myc",",","junB",",","and","fra-1","mRNAs","was","increased","in","activated","peripheral","blood","lymphocytes","incubated","with","ciprofloxacin","compared","to","that","in","untreated","controls","."],"ner_tags":[0,0,0,3,4,4,4,4,4,4,4,4,4,4,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"3655","tokens":["This","multiple","cytokine","production","deficiency","could","not","be","restored","by","IL-2","or","co-stimulatory","signals","provided","by","antigen-presenting","cells","(","APC",")","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,7,8,0,7,0,0]}
{"id":"10598","tokens":["IFN-gamma","triggers","a","well-defined","signal","transduction","pathway",",","which","although","not","directly","stimulated","by","monocyte","adherence","to","fibronectin","or","arginine-glycine-aspartate","(","RGD",")","-coated","substrata",",","was","enhanced","significantly","in","these","matrix-adherent","cells","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,10,10,10,10,0,0,0,0,0,0,7,8,0]}
{"id":"14557","tokens":["These","results","are","consistent","with","the","interpretation","that","glucocorticoid-mediated","autoregulation","of","GR","expression","is","a","tissue-specific","primary","transcriptional","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13373","tokens":["In","both","activated","peripheral","blood","T","lymphocytes","and","activated","tumorigenic","T","cell","lines",",","IL-2","gene","expression","was","blocked","at","the","transcriptional","level","by","okadaic","acid","."],"ner_tags":[0,0,7,8,8,8,8,0,5,6,6,6,6,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5549","tokens":["Furthermore",",","myricetin","was","also","found","to","inhibit","NFkappaB","activity","correlated","with","suppression","of","monocyte","adhesion","to","ECV304","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"2125","tokens":["Activation","of","the","transcription","factor","NF-kappa","B","is","reported","to","be","necessary","but","not","sufficient","for","E-selectin","expression","in","EC","."],"ner_tags":[0,0,0,9,10,9,10,0,0,0,0,0,0,0,0,0,9,0,0,5,0]}
{"id":"18545","tokens":["Effects","similar","to","gp160","were","seen","with","anti-CD4","mAb","."],"ner_tags":[0,0,0,9,0,0,0,9,10,0]}
{"id":"10365","tokens":["In","pre-B","cells","(","Ba\/F3",")",",","the","transactivation","domain","of","Stat6","was","IL-4","regulated",",","independently","from","its","DNA","binding","function","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"14762","tokens":["Anti-TR55","antibody","cross-linking","in","chronically","infected","U1","promonocytic","cultures","could","only","partially","substitute","for","TNF-alpha-induced","HIV-1","expression","."],"ner_tags":[9,10,0,0,5,6,6,6,6,0,0,0,0,0,0,0,0,0]}
{"id":"15947","tokens":["We","demonstrated","in","earlier","studies","that","the","upstream","region","of","the","mouse","GM-CSF","promoter","at","positions","between","-95","and","-73","is","essential","for","transcriptional","activation","in","response","to","PMA\/A23187","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,1,2,2,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"15710","tokens":["In","spite","of","its","association","with","p50","in","vitro",",","however",",","we","found","a","lymphoid","cell-specific","nuclear","factor","in","vivo","that","contains","c-Rel","but","not","p50","epitopes",";","this","factor",",","termed","IL-6","kappa","B","binding","factor","II",",","appears","to","contain","the","c-Rel","homodimer","and","preferentially","recognizes","several","IL-6","kappa","B-related","kappa","B","motifs","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,9,0,0,9,10,0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,9,10,0,0,0,0,1,2,2,2,2,2,0]}
{"id":"3080","tokens":["A","large","prospective","trial","is","needed","to","determine","if","one","or","more","of","these","biomarkers",",","is","predictive","of","breast","cancer","development","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4646","tokens":["Nuclear","run-on","experiments","showed","that","E3330","decreases","transcriptional","activation","of","TNF-alpha","gene","induced","by","lipopolysaccharide","(","LPS",")","stimulation","in","human","peripheral","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"5930","tokens":["TNF","is","the","major","inducer","of","NF-kappaB","and","particularly","of","the","p50-p65","complex",",","whereas","IL-7","acts","as","a","cofactor","by","sustaining","the","expression","of","the","p75","TNF","receptor","."],"ner_tags":[9,0,0,0,0,0,9,0,0,0,0,9,10,0,0,9,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"12316","tokens":["Restoration","of","the","CCAAT","box","or","insertion","of","an","erythroid","Kruppel-like","factor","(","EKLF",")","binding","site","in","the","delta","promoter","activates","its","expression","in","several","erythroid","cell","lines","."],"ner_tags":[0,0,0,1,2,0,0,0,0,1,2,2,2,2,2,2,2,0,0,1,2,0,0,0,0,0,5,6,6,0]}
{"id":"14841","tokens":["Two","stable","B","cell","lines","were","established",":","R59Z","activator","cells","were","used","to","induce","lytic","EBV","expression","in","a","constitutive","manner","by","the","production","of","the","BZLF","1","trans-activator","(","Zta",")","."],"ner_tags":[0,0,5,6,6,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"9390","tokens":["Binding","of","ER","to","an","estrogen","response","element","was","enhanced","by","addition","of","rabbit","reticulocyte","lysate","."],"ner_tags":[0,0,9,0,0,1,2,2,0,0,0,0,0,0,0,0,0]}
{"id":"9869","tokens":["CONCLUSION",":","Enhanced","IL-5","production","by","helper","T","cells","seems","to","cause","the","eosinophilic","inflammation","of","both","atopic","and","nonatopic","asthma","."],"ner_tags":[0,0,0,9,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"758","tokens":["From","supershift","experiments","it","was","concluded","that","one","DNA-binding","complex","contained","Stat1","alpha",",","probably","as","a","homodimer","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,10,0,0,0,0,0,0]}
{"id":"12838","tokens":["We","conclude","that","cord","lymphocyte","activation","exhibits","an","adult-type","profile","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11327","tokens":["In","parallel","with","the","decreased","cytokine","generation",",","each","cytokine","mRNA","was","less","expressed","in","the","presence","of","10","(","-5",")","M","Azeptin","."],"ner_tags":[0,0,0,0,0,9,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3056","tokens":["Steroid-resistant","asthma","."],"ner_tags":[0,0,0]}
{"id":"17866","tokens":["Activation","of","JAK3",",","but","not","JAK1",",","is","critical","for","IL-2","-induced","proliferation","and","STAT5","recruitment","by","a","COOH-terminal","region","of","the","IL-2","receptor","beta-chain","."],"ner_tags":[0,0,9,0,0,0,9,0,0,0,0,9,0,0,0,9,0,0,0,9,10,0,0,9,10,10,0]}
{"id":"11077","tokens":["EMS","analyses","performed","with","nuclear","extracts","from","Tax-expressing","Jurkat","cells","and","HTLV-I-transformed","peripheral","blood","mononuclear","cells","demonstrate","that","Tax","prevents","the","formation","of","U1","(","U1A\/U1B",")","and","U2","DNA-protein","complexes","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,0,7,8,8,8,8,0,0,9,0,0,0,0,1,0,1,0,0,1,9,10,0]}
{"id":"16887","tokens":["Therefore",",","two","different","negative","regulatory","pathways","are","involved","in","c-myc","regulation",":","one","which","is","independent","and","one","which","depends","on","de","novo","protein","synthesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17576","tokens":["Whereas","c-Fos\/c-Jun","heterodimers","do","not","exist","in","B","cells",",","they","form","and","bind","to","the","X2-box","in","class","II","nonexpressing","cells","."],"ner_tags":[0,9,10,0,0,0,0,5,6,0,0,0,0,0,0,0,1,0,5,6,6,6,0]}
{"id":"395","tokens":["Northern","blot","analysis","showed","that","TCDD","treatment","decreased","steady","state","levels","of","CD19","mRNA","by","67","%","in","the","IM-9","cell","line","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,5,6,6,0]}
{"id":"12771","tokens":["These","regulatory","elements","situated","downstream","of","transcription","interact","with","constitutive","and","inducible","transcription","factors",",","mediate","transmission","of","cellular","activation","signals",",","and","are","important","for","efficient","HIV-1","transcription","and","replication","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15312","tokens":["In","contrast","to","the","transient","NF-kappa","B","activation","induced","by","phorbol","ester",",","the","permanent","NF-kappa","B","translocation","induced","by","HIV","infection","was","not","dependent","on","PKC","isoenzymes","alpha","and","beta","as","shown","by","the","use","of","a","specific","inhibitor","(","GF","109203X",")","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7077","tokens":["The","human","T-cell","leukemia","virus","type","1","(","HTLV-1",")","transcriptional","trans-activator","Tax","has","been","demonstrated","to","have","transforming","activity","in","multiple","cell","culture","and","transgenic-mouse","models","."],"ner_tags":[0,9,10,10,10,10,10,10,10,10,10,10,9,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0]}
{"id":"15309","tokens":["The","activity","of","the","promoter","regulating","the","synthesis","of","the","p105","precursor","of","the","NF-kappa","B","p50","subunit","was","enhanced","in","these","cells","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,9,10,0,0,9,10,10,10,0,0,0,0,0,0]}
{"id":"769","tokens":["It","was","found","that","the","propagation","of","the","Tat","mutants","containing","wild-type","LTRs","was","less","efficient","than","that","of","the","LTR-modified","Tat","mutants","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,1,2,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"9756","tokens":["Both","proteins","display","a","high","turnover","in","B","cells","although","I","kappa","B","beta","is","considerably","more","stable","than","I","kappa","B","alpha","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,9,10,10,10,0,0,0,0,0,9,10,10,10,0]}
{"id":"9015","tokens":["Interleukin-10","(","IL-10",")","helps","maintain","polarized","T-helper","cells","in","a","T-helper","lymphocyte","2","(","Th2",")","phenotype","."],"ner_tags":[9,0,9,0,0,0,7,8,8,0,0,7,8,8,8,8,8,8,0]}
{"id":"6646","tokens":["Signal","transduction","pathways","in","normal","human","monocytes","stimulated","by","cytokines","and","mediators",":","comparative","study","with","normal","human","neutrophils","or","transformed","cells","and","the","putative","roles","in","functionality","and","cell","biology","."],"ner_tags":[0,0,0,0,7,8,8,0,0,9,0,0,0,0,0,0,7,8,8,0,5,6,0,0,0,0,0,0,0,0,0,0]}
{"id":"2624","tokens":["An","isoform","lacking","exon","11","destroyed","the","carboxy-terminal","leucin-zipper","region","and","introduced","a","frame","shift","creating","a","novel",",","proline-rich","carboxy","terminus","."],"ner_tags":[0,0,0,1,2,0,0,9,10,10,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"10677","tokens":["These","results","suggest","that","PI3-K","is","involved","in","NFAT","activation","through","a","complex","adaptor","function","of","its","regulatory","subunit","and","that","its","lipid","kinase","activity","is","dispensable","for","this","effect","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"12819","tokens":["Uncoupling","activation-dependent","HS1","phosphorylation","from","nuclear","factor","of","activated","T","cells","transcriptional","activation","in","Jurkat","T","cells",":","differential","signaling","through","CD3","and","the","costimulatory","receptors","CD2","and","CD28","."],"ner_tags":[0,0,9,0,0,9,10,10,10,10,10,0,0,0,5,6,6,0,0,0,0,9,0,0,0,0,9,0,9,0]}
{"id":"6631","tokens":["Further",",","LMP1","does","not","require","TRADD","residues","294","to","312","for","NF-kappaB","activation",",","while","TNFR1","requires","TRADD","residues","296","to","302","."],"ner_tags":[0,0,9,0,0,0,9,0,0,0,0,0,9,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"809","tokens":["Reduced","mitogenic","stimulation","of","peripheral","blood","mononuclear","cells","as","a","prognostic","parameter","for","the","course","of","breast","cancer",":","a","prospective","longitudinal","study","."],"ner_tags":[0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16671","tokens":["By","comparison",",","PMA","is","a","very","inefficient","inducer","of","the","jun","gene","family","in","Jurkat","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,5,6,0]}
{"id":"4267","tokens":["Stimulation","of","B","lymphocytes","by","either","ligation","of","CD40","Ag","or","cross-linking","the","Ig","receptor","is","also","insufficient","to","render","B","lymphocytes","responsive","to","1","alpha",",","25","(","OH",")","2D3","."],"ner_tags":[0,0,7,8,0,0,0,0,9,10,0,0,0,9,10,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"648","tokens":["Pretreatment","of","monocytes","with","pertussis","toxin","inhibited","these","functions","of","PAF",",","whereas","cholera","toxin","had","no","inhibitory","effect","."],"ner_tags":[0,0,7,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"11123","tokens":["Regulation","of","the","tissue","factor","gene","in","human","monocytic","cells","."],"ner_tags":[0,0,0,1,2,2,0,7,8,8,0]}
{"id":"11592","tokens":["We","suggest","that","the","T","cell-specific","expression","of","the","IL-3","gene","is","partly","controlled","through","the","enhancer","by","cooperation","between","Oct","and","NFAT","family","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"9873","tokens":["Because","monocytes","play","a","pivotal","role","in","the","pathophysiology","of","intravascular","coagulation","activation","through","their","ability","to","synthesize","tissue","factor","(","TF",")",",","we","asked","(","1",")","whether","monocyte","TF","activation","occurs","in","cardiac","transplant","recipients","and","(","2",")","whether","monocyte","TF","expression","is","affected","by","treatment","with","cyclosporin","A","(","CsA",")","."],"ner_tags":[0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"793","tokens":["The","activation","of","the","Jak","-STAT","1","signaling","pathway","by","IL-5","in","eosinophils","."],"ner_tags":[0,0,0,0,9,9,10,0,0,0,9,0,7,0]}
{"id":"7309","tokens":["However",",","the","rapamycin-resistant","p70","(","s6k",")","could","not","rescue","rapamycin","inhibition","of","T-cell","cycle","entry",",","consistent","with","the","involvement","of","additional",",","rapamycin-sensitive","pathways","in","the","control","of","T-cell","cycle","progression","."],"ner_tags":[0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17603","tokens":["A","7-base-pair","mutation","in","the","site","B","palindrome",",","which","destroyed","protein","binding",",","resulted","in","increased","expression","from","the","human","immunodeficiency","virus","type","1","long","terminal","repeat","in","T","cells","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,7,8,0]}
{"id":"15884","tokens":["Together","these","results","constitute","the","first","direct","evidence","of","a","positive","role","for","the","lymphoid-specific","octamer-binding","factor","in","DRA","gene","transcription","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"9720","tokens":["The","spatial","distribution","of","human","immunoglobulin","genes","within","the","nucleus",":","evidence","for","gene","topography","independent","of","cell","type","and","transcriptional","activity","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16840","tokens":["This","``","octamer","``","in","the","context","of","DRA","appears","capable","of","binding","both","the","ubiquitous","(","OTF-1",")","and","lymphoid-specific","(","OTF-2",")","``","octamer","''","binding","proteins",",","but","at","least","one","other","distinct","``","octamer","''","complex","was","found","."],"ner_tags":[0,0,1,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,9,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,9,10,10,10,0,0,0]}
{"id":"12320","tokens":["Constitutive","association","of","JAK1","and","STAT5","in","pro-B","cells","is","dissolved","by","interleukin-4","-induced","tyrosine","phosphorylation","of","both","proteins","."],"ner_tags":[0,0,0,9,0,9,0,7,8,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"7108","tokens":["Taken","together",",","DZA","promotes","the","proteolytic","degradation","of","IkappaBalpha",",","but","not","IkappaBbeta",",","resulting","in","an","increase","of","DNA","binding","activity","of","NF-kappaB","in","the","nucleus","in","the","absence","of","its","transcriptional","activity","in","RAW","264.7","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"336","tokens":["Transient","transfection","assays","with","EGR-1","promoter","fragments","linked","to","the","chloramphenicol","acetyltransferase","(","CAT",")","gene","demonstrated","that","PWM","induced","EGR-1","transcription","is","conferred","by","the","CArG","motif","(","C","C","[","AT","]","6GG",")","in","the","EGR-1","promoter","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,1,2,2,2,2,2,0,0,9,0,1,0,0,0,0,0,1,2,0,1,2,2,2,2,2,0,0,0,1,2,0]}
{"id":"14092","tokens":["HMG","box","containing","transcription","factors","in","lymphocyte","differentiation","."],"ner_tags":[9,10,0,9,10,0,7,0,0]}
{"id":"11151","tokens":["On","the","other","hand",",","FCM","produced","in","the","presence","of","indomethacin","does","not","inhibit","NF-kappaB","activation","by","LPS","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"10242","tokens":["Induction","of","nuclear","factor","kappa","B\/Rel","nuclear","activity","in","human","peripheral","blood","T","lymphocytes","by","anti-HLA","class","I","monoclonal","antibodies","."],"ner_tags":[0,0,9,10,10,10,0,0,0,7,8,8,8,8,0,9,10,10,10,10,0]}
{"id":"7047","tokens":["RESULTS",":","The","number","of","glucocorticoid","receptors","on","mononuclear","leukocytes","(","MNL",")","was","comparable","in","patients","with","anorexia","nervosa",",","patients","with","active","Cushing","'s","disease",",","and","normal","subjects","(","binding","capacity","3.3","+\/-","0.23","vs.","3.7","+\/-","0.30","and","3.5","+\/-","0.20","fmol\/10","(","6",")","cells",")","."],"ner_tags":[0,0,0,0,0,9,10,0,7,8,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16608","tokens":["These","transcripts","initiate","from","one","of","two","promoters",",","Cp","or","Wp",",","that","function","in","a","mutually","exclusive","fashion","."],"ner_tags":[0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13572","tokens":["Copyright","1998","Elsevier","Science","Ireland","Ltd","."],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"4563","tokens":["IL-13","caused","rapid","phosphorylation","of","the","three","out","of","four","members","of","the","known","Janus","family","of","kinases","(","JAKs",")","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0]}
{"id":"5492","tokens":["These","transcription","factors","are","post-transcriptionally","regulated","by","their","assembly","with","a","second","family","of","inhibitory","proteins","termed","I","kappa","B","that","serve","to","sequester","the","NF-kappa","B\/Rel","complexes","in","the","cytoplasm","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,10,0,0,0,0,0,9,10,10,0,0,0,0]}
{"id":"2158","tokens":["In","this","study","we","have","identified","the","peroxisome","proliferator-activated","receptor","(","PPAR",")","as","a","new","thyroid","hormone","receptor","(","THR",")","auxiliary","nuclear","protein",",","heterodimerizing","with","THR","in","solution","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,9,10,10,10,10,10,10,10,10,0,0,0,9,0,0,0]}
{"id":"5184","tokens":["Pretreatment","with","a","protein","kinase","C","activator",",","phorbol","12-myristate","13-acetate",",","caused","almost","complete","inhibition","of","histamine-induced","[","Ca2+","]","i","rise",",","but","did","not","do","so","by","activators","of","cAMP-","and","cGMP-dependent","protein","kinases","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"15298","tokens":["In","addition",",","the","product","of","the","proto-oncogene","c-rel","can","bind","to","similar","DNA","motifs","by","itself","or","as","a","heterodimer","with","p50","or","p65","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"3359","tokens":["Although","it","has","been","postulated","that","pituitary","endocrine","cells","and","pancreatic","endocrine","beta-cells","share","identical","Pan\/E2A","complexes",",","native-Western","analyses","of","pituitary","and","endocrine","beta-cells","detect","Pan","proteins","in","distinct","cell","type-specific","complexes","."],"ner_tags":[0,0,0,0,0,0,7,8,8,0,7,8,8,0,0,9,10,0,0,0,0,0,0,7,8,0,9,10,0,0,9,10,10,0]}
{"id":"130","tokens":["Northern","blot","analysis","indicated","the","expression","of","human","PEBP2","alpha","A",",","alpha","B","(","AML1",")",",","and","beta","genes","in","Jurkat","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,1,2,0,1,0,0,0,1,2,0,5,6,0]}
{"id":"15783","tokens":["The","GATA-1","gene",",","though","virtually","silent","in","quiescent","progenitors",",","is","activated","after","entrance","into","the","cell","cycle","upon","stimulation","with","hematopoietic","growth","factors","."],"ner_tags":[0,1,2,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"906","tokens":["EBNA-2","is","known","to","interact","with","the","cellular","DNA-binding","protein","J","kappa","and","is","recruited","to","promoters","containing","the","GTGGGAA","J","kappa","recognition","sequence","."],"ner_tags":[9,0,0,0,0,0,0,9,10,10,9,10,0,0,0,0,1,0,0,0,1,2,2,2,0]}
{"id":"12021","tokens":["Reactivation","of","Kaposi","'s","sarcoma-associated","herpesvirus","infection","from","latency","by","expression","of","the","ORF","50","transactivator",",","a","homolog","of","the","EBV","R","protein","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,9,10,10,0]}
{"id":"12297","tokens":["We","have","used","a","human","T-lymphotropic","virus","type","1","(","HTLV-1",")","model","of","cAMP","response","element","(","CRE",")","transcription","to","investigate","the","influence","of","lymphocyte","activation","on","transcription","from","homologous","regions","in","the","viral","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"16939","tokens":["The","patients","carrying","B27","antigen","had","lymphocytic","receptor","concentrations","under","the","levels","of","such","in","patients","free","of","the","antigen","carriage","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10676","tokens":["Wortmannin","did","not","interfere","with","NFAT","activation",",","although","it","inhibited","PI3-K","and","Erk2","activation","in","the","same","experiment","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,9,0,9,0,0,0,0,0,0]}
{"id":"6125","tokens":["To","determine","the","functionality","of","both","the","C\/EBP-","and","GATA-","binding","sites",",","we","analyzed","whether","C\/EBPbeta","and","GATA-1","can","stimulate","the","MBP","promoter","in","the","C\/EBPbeta","and","GATA-1","negative","Jurkat","T-cell","line","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,9,0,9,0,0,0,1,2,0,0,5,6,6,6,6,6,6,0]}
{"id":"16009","tokens":["The","results","suggest","that","M-CSF","induction","of","M-CSF","involves","G","proteins",",","PKC","and","NF","kappa","B","."],"ner_tags":[0,0,0,0,9,0,0,9,0,9,10,0,9,0,9,10,10,0]}
{"id":"9645","tokens":["The","effects","of","chemically","prepared","monochloramine","(","NH2Cl",")","on","protein","kinase","C","(","PKC",")","and","PKC","-mediated","cellular","responses","were","studied","in","elicited","rat","peritoneal","neutrophils","and","human","Jurkat","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,9,0,0,0,0,0,0,7,8,8,8,0,5,6,6,6,0]}
{"id":"6641","tokens":["DNA","fragmentation","was","efficiently","blocked","by","the","caspase","inhibitor","Z-VAD-fmk","and","partially","blocked","by","Ac-DEVD-fmk",",","suggesting","that","SN50-mediated","apoptosis","is","caspase","-dependent","."],"ner_tags":[0,0,0,0,0,0,0,9,10,9,0,0,0,0,9,0,0,0,0,0,0,9,0,0]}
{"id":"6364","tokens":["This","decrease","was","observed","at","2","hr",",","reached","a","nadir","at","4","hr",",","and","returned","to","baseline","levels","at","24","hr","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15831","tokens":["Forty-five","of","these","reports","are","cited","in","this","review","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"607","tokens":["We","have","now","demonstrated","that","a","second","SSE-like","element","in","the","5'-untranslated","region","of","the","gamma-gene","also","contributes","to","this","competitive","silencing","of","the","beta-gene","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,1,2,0,0,1,0,0,0,0,0,0,0,0,1,0]}
{"id":"4551","tokens":["Therefore",",","as","T","cells","progress","from","primary","TCR","activation","through","IL-2","-dependent","proliferation",",","followed","by","secondary","TCR","stimulation",",","their","responsiveness","to","IFN-gamma","varies",",","and","this","may","affect","their","ability","to","participate","in","an","ongoing","immune","response","."],"ner_tags":[0,0,0,7,8,0,0,0,9,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5660","tokens":["Both","the","wild","type","430-444","and","433-442","peptides","stimulated","a","HSV-specific","T","cell","clone","after","a","brief","incubation","with","antigen","presenting","cells","(","APC",")","expressing","DQ0302","at","acidic","pH","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,7,0,0,0,0,0,0,0]}
{"id":"15804","tokens":["We","report","here","that","the","second","alteration",",","at","threonine","78",",","also","plays","an","important",",","although","more","indirect",",","role",":","alteration","of","the","sequence","at","threonine","78","such","that","it","resembles","that","of","c-erb","A","can","act","as","an","intragenic","suppressor","and","can","partially","restore","function","to","a","v-erb","A","protein","rendered","defective","due","to","a","mutation","at","position","61","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0]}
{"id":"2998","tokens":["Within","the","region","between","-108","and","-40","base","pairs","of","the","IFN-gamma","promoter","are","two","conserved","and","essential","regulatory","elements",",","which","confer","activation-specific","expression","in","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,1,2,0,0,0,0,0,0,7,8,0]}
{"id":"6320","tokens":["Different","glucocorticoid","hormones","(","GCH",")","show","differences","in","the","intensity","and","in","the","kinetics","of","their","immunomodulating","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7209","tokens":["SOCS-3","protein","was","detectable","as","early","as","30","min","following","IL-2","stimulation",",","while","CIS","was","seen","only","at","low","levels","after","2","h","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"11169","tokens":["AP-1","derived","from","mature","monocytes","and","astrocytes","preferentially","interacts","with","the","HTLV-I","promoter","central","21","bp","repeat","."],"ner_tags":[9,0,0,7,8,0,7,0,0,0,0,1,2,0,1,2,2,0]}
{"id":"8106","tokens":["In","this","study",",","transient","cotransfection","of","several","GPIX","promoter\/reporter","constructs","into","293T","kidney","fibroblasts","with","a","Fli-1","expression","vector","shows","that","the","oncogenic","protein","Fli-1","can","transactivate","the","GPIX","promoter","when","an","intact","GPIX","Ets","site","is","present","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,5,6,6,0,0,1,2,2,0,0,0,0,0,9,0,0,0,1,2,0,0,0,1,2,2,0,0,0]}
{"id":"498","tokens":["Yet","these","same","cells","do","initiate","early","TCR","-mediated","signaling","events",",","such","as","generation","of","inositol","phosphates","and","increased","intracellular","calcium","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5443","tokens":["These","results","are","the","first","to","suggest","that","surfactant","'s","suppressive","effects","on","inflammatory","cytokine","production","may","involve","transcriptional","regulation","through","inhibition","of","NF-kappa","B","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"547","tokens":["Furthermore",",","we","demonstrate","that","p21ras","is","essential","for","NO-induced","downstream","signaling",",","such","as","NF-kappa","B","activation",",","and","that","endogenous","NO","can","activate","p21ras","in","the","same","cell","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"16965","tokens":["In","the","four","families","with","an","autosomal","dominant","mode","of","transmission","there","was","always","one","parent","with","reduced","receptor","binding","in","peripheral","mononuclear","leucocytes","and","elevated","serum","hormone","levels","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0]}
{"id":"6742","tokens":["A","high","expression","of","WT1","has","been","detected","in","a","range","of","acute","leukemias",",","and","WT1","is","downregulated","during","induced","differentiation","of","some","leukemic","cell","lines","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"2109","tokens":["Four","complexes","are","identified","by","the","electrophoretic","mobility","shift","assay",",","two","of","which","are","induced","by","mitogen","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"15164","tokens":["The","results","showed","that","the","activity","of","plasma","IL-1","in","aged","long-distance","runner","was","209","%",",","223","%","and","145","%","of","the","control","at","14.7-18.7",",","3.8-7.0","and","1.5-2.6","KD","fractions","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5929","tokens":["Tumor","necrosis","factor","(","TNF",")","and","interleukin-7","(","IL-7",")",",","secreted","during","this","interaction",",","are","critical","cytokines","for","HIV","long","terminal","repeat","transactivation","through","NF-kappaB","-dependent","activation","."],"ner_tags":[9,10,10,0,9,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,9,0,0,0]}
{"id":"12467","tokens":["Ovarian","and","breast","cytotoxic","T","lymphocytes","can","recognize","peptides","from","the","amino","enhancer","of","split","protein","of","the","Notch","complex","."],"ner_tags":[0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"2472","tokens":["We","have","examined","the","possibility","that","stimulation","of","phospholipase","D","(","PLD",")","may","regulate","activation","of","transcription","factor","AP-1","in","human","T","cells","by","transfecting","human","T","lymphocyte","Jurkat","cells","with","a","plasmid","containing","an","AP-1","enhancer","element","and","a","chloramphenicol","acetyltransferase","reporter","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,1,2,2,0,0,1,2,2,2,0]}
{"id":"3044","tokens":["Pentoxifylline",",","a","trisubstituted","xanthine","derivative",",","has","been","used","to","decrease","blood","viscosity","and","is","reasonably","well","tolerated","by","most","recipients","of","the","drug","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1143","tokens":["As","signal","transduction","is","facilitated","by","prooxidant","conditions",",","we","propose","that","the","well-known","immunological","consequences","of","GSH","depletion","ultimately","may","be","results","of","the","accompanying","GSSG","deficiency","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16722","tokens":["The","involvement","of","ion","channels","in","B","and","T","lymphocyte","activation","is","supported","by","many","reports","of","changes","in","ion","fluxes","and","membrane","potential","after","mitogen","binding","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"18167","tokens":["The","transcriptional","activity","of","the","IL-2","promoter","requires","T-cell","costimulation","delivered","by","the","TCR","and","the","auxiliary","receptor","CD28","."],"ner_tags":[0,0,0,0,0,1,2,0,7,0,0,0,0,9,0,0,9,10,10,0]}
{"id":"2397","tokens":["RESULTS","."],"ner_tags":[0,0]}
{"id":"12509","tokens":["This","polymorphism","represented","a","C-to-T","base","exchange","which","induced","a","YY1","consensus","sequence","and","is","present","in","a","region","of","the","promoter","associated","with","negative","transcription","regulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10297","tokens":["This","activity","requires","regions","of","SLP-76","that","mediate","protein-protein","interactions","with","other","molecules","in","T","cells",",","suggesting","that","SLP-76","-associated","proteins","also","function","to","regulate","signal","transduction","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"8797","tokens":["Our","unexpected","observations","of","paternal","or","biallelic","expression","of","WT1","in","fibroblasts","and","lymphocytes",",","together","with","the","previous","findings","of","maternal","or","biallelic","expression","in","placentae","and","brains",",","suggest","that","the","allele-specific","regulatory","system","of","WT1","is","unique","and","may","be","controlled","by","a","putative","tissue-","and","individual-specific","modifier","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,7,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14547","tokens":["We","therefore","propose","a","model","whereby","a","core","NFAT","complex","consisting","of","Jun",",","Fos",",","and","a","constitutive","nuclear","factor","is","formed","in","both","T","and","B","cells",",","but","an","additional","factor","and\/or","post-translational","modification","of","a","factor",",","missing","in","B","cells",",","might","be","required","for","transactivation","by","NFAT","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,9,0,9,0,0,0,9,10,10,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,9,0]}
{"id":"5428","tokens":["Previous","work","has","suggested","that","activation","of","the","transcription","factor","activator","protein","1","(","AP-1",")","is","one","LPS-induced","event","that","mediates","this","response","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,10,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"3858","tokens":["The","5","'","flanking","sequence","has","promoter","activity","which","is","elevated","by","interferon","alpha","."],"ner_tags":[0,1,2,2,2,0,0,0,0,0,0,0,9,10,0]}
{"id":"11804","tokens":["The","requirement","of","another","regulatory","element","called","CLE0",",","which","lies","downstream","of","the","-70","GATA","site",",","was","also","demonstrated","."],"ner_tags":[0,0,0,0,1,2,0,1,0,0,0,0,0,0,1,2,2,0,0,0,0,0]}
{"id":"6226","tokens":["IL-13","activation","of","STAT6","was","reduced","in","MDMac","which","was","associated","with","diminished","IL-13","-induced","expression","of","CD23","and","MHC","class","II","."],"ner_tags":[9,0,0,9,0,0,0,5,0,0,0,0,0,9,0,0,0,9,0,9,10,10,0]}
{"id":"16657","tokens":["OBJECTIVE",":","The","aim","was","to","explore","the","down-regulation","of","the","glucocorticoid","receptors","during","hypercortisolaemia","in","anorexia","nervosa","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"7030","tokens":["GR","binding","parameters","did","not","differ","significantly","between","patients","(","Kd","8.98","+\/-","1.07","nM",",","Bmax","183","+\/-","29.8","fmol\/mg",")","and","controls","(","Kd","9.36","+\/-","1.17","nM",",","Bmax","158","+\/-","16","fmol\/mg",")","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9559","tokens":["We","now","show","that","IL-2","regulation","of","STAT3","proteins","in","T","cells","is","a","complex","response","involving","activation","of","two","forms","of","STAT3",":","90-kDa","STAT3alpha","and","an","83-kDa","carboxyl-terminal","truncated","STAT3beta","."],"ner_tags":[0,0,0,0,9,0,0,9,10,0,7,8,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,9,10,10,10,0]}
{"id":"12857","tokens":["The","AD1","and","AD2","transactivation","domains","of","E2A","are","essential","for","the","antiapoptotic","activity","of","the","chimeric","oncoprotein","E2A-HLF","."],"ner_tags":[0,9,0,9,0,0,0,9,0,0,0,0,0,0,0,0,9,10,9,0]}
{"id":"5426","tokens":["Activation","of","c-Jun","N-terminal","kinase","in","bacterial","lipopolysaccharide-stimulated","macrophages","."],"ner_tags":[0,0,9,10,10,0,7,8,8,0]}
{"id":"11869","tokens":["Activation","of","the","NF-kappaB","transcription","factor","in","a","T-lymphocytic","cell","line","by","hypochlorous","acid","."],"ner_tags":[0,0,0,9,9,10,0,0,5,6,6,0,0,0,0]}
{"id":"2921","tokens":["The","survival","rate","of","tal-1","transgenic","animals","was","much","lower","as","compared","with","control","mice","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18414","tokens":["This","injury","was","significantly","inhibited","by","intravenous","pretreatment","of","the","mice","with","a","water-soluble","emulsion","of","alpha-tocopherol","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8938","tokens":["We","further","show","that","Nmi","interacts","with","all","STATs","except","Stat2","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,9,0]}
{"id":"15132","tokens":["Based","on","these","results","we","estimate","a","5-10","%","difference","in","virus","production","of","the","LTR","variants","when","compared","to","that","of","wild-type","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0]}
{"id":"18006","tokens":["Now",",","we","report","the","solution","structure","of","the","sequence-specific","HMG-box","of","the","SRY-related","protein","Sox-4","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,9,0]}
{"id":"5179","tokens":["H1-agonists","(","histamine","and","2-methylhistamine",")","caused","a","transient","rise","of","[","Ca2+","]",",","and","H1-antagonists","(","pyrilamine","and","doxepin",")","inhibited","the","histamine-induced","[","Ca2+","]","i","rise","more","potently","than","the","H2-antagonist","(","cimetidine",")","on","the","H3-antagonist","(","impromidine",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8865","tokens":["We","observed","in","the","present","study","that","lysoPC","(","1","to","10","micromol\/L",")","dose-dependently","reduced","TF","activity","in","human","monocytes",",","as","elicited","by","lipopolysaccharide","(","LPS",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,0,0,0,0,0,0,0,0,0]}
{"id":"14694","tokens":["The","functional","domains","of","HS-40","were","also","mapped","."],"ner_tags":[0,0,0,0,1,0,0,0,0]}
{"id":"12225","tokens":["T-lineage","precursor","populations","from","the","adult","mouse","thymus",",","prior","to","T-cell","receptor","gene","rearrangement",",","display","a","capacity","to","produce","DC","as","well","as","T","cells","in","the","thymus",",","and","are","very","efficient","precursors","of","DC","in","culture","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,7,0,0,0]}
{"id":"786","tokens":["This","form","of","latency",",","termed","latency","III",",","is","also","encountered","in","some","posttransplant","lymphoproliferative","disorders","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5447","tokens":["To","identify","the","molecular","basis","for","specificity","and","inducibility",",","the","chromatin","configuration","of","the","human","B7.1","gene","was","examined","in","intact","nuclei","from","various","cell","types","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"16690","tokens":["A","new","homeobox","gene",",","HB24",",","has","been","isolated","from","a","human","B-lymphocyte","cDNA","library","."],"ner_tags":[0,0,1,2,0,1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17094","tokens":["The","two","latter","signals","were","nevertheless","able","to","induce","NF-kappa","B","translocation","with","a","pattern","in","the","band-shift","assay","indistinguishable","from","that","observed","using","phorbol","ester","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3525","tokens":["Naive","(","CD45RA+",")","T","lymphocytes","are","more","sensitive","to","oxidative","stress-induced","signals","than","memory","(","CD45RO+",")","cells","."],"ner_tags":[7,8,8,8,8,8,0,0,0,0,0,0,0,0,7,8,8,8,8,0]}
{"id":"17838","tokens":["Productive","infection","of","T","cells","with","human","immunodeficiency","virus","1","(","HIV-1",")","typically","requires","that","the","T","cells","be","stimulated","with","antigens","or","mitogens","."],"ner_tags":[0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"31","tokens":["High-dose","estrogen","administration","induces","anemia","in","mammals","."],"ner_tags":[0,0,0,0,0,0,0,0]}
{"id":"10831","tokens":["In","summary",",","these","studies","show","that","the","amount","of","G","(","S",")","alpha","expression","has","a","marked","impact","on","the","level","of","activity","of","the","AC","cascade","from","the","membrane","through","to","the","nucleus","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2312","tokens":["LIF","increased","steady-state","levels","of","HIV","mRNA","at","2.0",",","4.3",",","and","9.2","kB","."],"ner_tags":[9,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0]}
{"id":"583","tokens":["The","difference","in","the","number","of","recognized","peptides","by","patients","'","PBMC","before","RAI","and","surgery","may","reflect","the","effect","of","long","term","therapy","with","ATD","in","the","patients","before","RAI","vs.","the","shorter","period","in","patients","before","surgery","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5495","tokens":["Similarly",",","the","p105","precursor","of","the","NF-kappa","B","p50","subunit","is","also","post-translationally","processed","in","the","proteasome","."],"ner_tags":[0,0,0,9,10,0,0,9,10,9,10,0,0,0,0,0,0,9,0]}
{"id":"6956","tokens":["Molecular","and","biochemical","approaches","demonstrated","that","LMP1","usurps","cellular","signaling","pathways","resulting","in","the","induction","of","NF-kappaB","and","AP-1","via","two","C-terminal","activating","regions","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,10,10,0]}
{"id":"3892","tokens":["BZLF1","mRNA","and","the","product",",","an","immediate-early","gene","for","EBV","replication",",","was","not","expressed","in","any","of","them",",","thereby","suggesting","that","the","tumour","cells","carried","EBV","genomes","in","a","tightly","latent","form","."],"ner_tags":[3,4,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,1,2,0,0,0,0,0,0]}
{"id":"57","tokens":["A","brief","introduction","to","lineage","commitment","and","asymmetric","cell","division","is","followed","by","a","discussion","of","several","methods","used","to","identify","transcription","factors","important","in","specifying","hematopoietic","cell","types","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,7,8,8,0]}
{"id":"15028","tokens":["Transient","pseudohypoaldosteronism","in","obstructive","renal","disease","with","transient","reduction","of","lymphocytic","aldosterone","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"6346","tokens":["To","better","understand","the","assembly","mechanism","for","the","progesterone","receptor","(","PR",")",",","we","have","developed","cell-free","systems","for","studying","interactions","of","PR",",","hsp90",",","and","other","associated","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,9,10,0]}
{"id":"11520","tokens":["Arsenic","contents","in","hair","and","nail","were","increased",",","and","the","peak","content","of","arsenic","could","reach","2.5","to","2.7","microg\/g","tissue","at","CR","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17849","tokens":["Since","DCs","and","memory","T","cells","frequently","traffic","together","in","situ",",","these","unusual","heterologous","syncytia","could","develop","in","infected","individuals","and","lead","to","chronic","HIV-1","replication","without","ostensible","immune","stimulation","."],"ner_tags":[0,7,0,0,7,8,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8401","tokens":["The","master","switch","for","the","expression","of","these","genes","is","the","class","II","transactivator","(","CIITA",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"12524","tokens":["Previous","studies","have","demonstrated","that","these","cytokines","predominantly","activate","an","80","kDa","STAT5","isoform","in","mature","granulocytes","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"1444","tokens":["Peripheral","leucocyte","genomic","DNAs","were","obtained","from","41","patients","with","primary","ovarian","carcinoma","and","83","controls","from","Ireland",",","as","well","as","from","26","primary","ovarian","carcinoma","patients","and","101","controls","in","Germany","."],"ner_tags":[1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16118","tokens":["Demonstration","of","a","1",",","25-dihydroxyvitamin","D3-responsive","protein","in","human","lymphocytes",":","immunologic","crossreactivity","and","inverse","regulation","with","the","vitamin","D","receptor","."],"ner_tags":[0,0,0,9,10,10,10,10,0,7,8,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"18420","tokens":["Immunosuppression","by","glucocorticoids",":","inhibition","of","NF-kappa","B","activity","through","induction","of","I","kappa","B","synthesis","[","see","comments","]"],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"8124","tokens":["This","system","allowed","us","to","efficiently","express","in","developing","thymocytes","a","mutant","form","of","the","NF-kappa","B","inhibitor","I","kappa","B","alpha","(","mut-I","kappa","B",")","and","to","study","the","maturation","defects","occurring","when","NF-kappa","B","activation","is","inhibited","during","fetal","development","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,10,10,0,9,10,10,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"1230","tokens":["HTLV-I","Tax","expression","leads","to","the","constitutive","nuclear","expression","of","biologically","active","NF-kappa","B","and","c-Rel","complexes",";","however",",","the","biochemical","mechanism","(","s",")","underlying","this","response","remains","poorly","understood","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6668","tokens":["IL-5","is","produced","mainly","by","activated","T","cells",",","and","its","expression","is","regulated","at","the","transcriptional","level","."],"ner_tags":[9,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6426","tokens":["Numerous","cellular","and","biochemical","abnormalities","in","immune","regulation","have","been","described","in","patients","with","systemic","lupus","erythematosus","(","SLE",")",",","including","surface","Ag","receptor","-initiated","signaling","events","and","lymphokine","production","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,9,0,0]}
{"id":"4887","tokens":["Alternative","splicing","generates","type","A","and","B","transcripts","that","potentially","encode","two","entirely","distinct","proteins",";","type","A","transcripts","code","for","a","small","mitochondrial","protein",",","p8MTCP1",",","and","type","B","transcripts",",","containing","an","additional","open","reading","frame",",","may","code","for","107","amino-acid","protein",",","p13MTCP1","."],"ner_tags":[0,0,0,3,4,4,4,4,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,9,10,0,9,0,0,3,4,4,0,0,0,0,1,2,2,0,0,0,0,9,10,10,0,9,0]}
{"id":"3658","tokens":["To","determine","whether","the","functional","defect","of","the","patients","'","T","cells","was","due","to","the","absence","or","abnormal","binding","of","transcription","factors","involved","in","cytokine","gene","expression",",","electrophoretic","mobility","shift","assays","were","used","to","examine","the","DNA","binding","of","AP-1",",","Oct",",","CREB",",","SP1",",","NF-kappa","B","and","the","nuclear","factor","of","activated","T","cells","(","NF-AT",")","to","their","respective","response","elements","in","the","promoter","of","the","IL-2","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,9,10,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,9,0,9,0,9,10,0,0,9,10,10,10,10,10,0,9,0,0,0,0,1,2,0,0,1,0,0,1,2,0]}
{"id":"3212","tokens":["To","confirm","the","physiological","relevance","of","these","findings",",","we","carried","out","in","vivo","footprinting","experiments","which","showed","that","stimulation","of","IL-2R","alpha","expression","correlated","with","occupancy","of","the","GASd","element","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,1,2,0]}
{"id":"16450","tokens":["The","detection","of","estrogen","and","progesterone","receptors","(","ER","and","PR",")","localized","in","the","cell","nucleus","can","be","achieved","by","the","same","assay","."],"ner_tags":[0,0,0,9,0,9,10,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5394","tokens":["The","active","vitamin","D3","metabolite","1",",","25-dihydroxycholecalciferol","(","1",",","25","(","OH",")","2D3",")","acts","as","an","antiproliferative","and","differentiating","agent","for","the","monoblastoid","cell","line","U937","and","as","an","important","immunologic","mediator","implicated","particularly","in","the","function","of","cells","belonging","to","the","monocyte\/macrophage","lineage","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"4104","tokens":["Activation","of","the","erythropoietin","receptor","caused","specific","DNA-binding","of","Stat","5b",",","but","failed","to","induce","reporter","gene","transcription","."],"ner_tags":[0,0,0,9,10,0,0,0,0,9,10,0,0,0,0,0,1,2,0,0]}
{"id":"16955","tokens":["This","complementary","DNA","encoded","a","protein","with","structural","similarities","to","the","c-jun","proto-oncogene","product",",","and","its","target","sequence","was","closely","related","to","the","palindromic","target","sequence","of","c-jun","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,1,2,2,0,1,0]}
{"id":"12885","tokens":["We","further","demonstrated","that","IL-2",",","-7",",","and","-15","induce","multiple","STAT","proteins",",","including","STAT5a",",","STAT5b",",","STAT1","alpha",",","STAT3",",","and","another","unidentified","Fc","gamma","RI","GAS","DNA-binding","protein","."],"ner_tags":[0,0,0,0,9,10,10,10,10,10,0,9,10,10,0,0,9,0,9,0,9,10,0,9,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"18225","tokens":["We","have","shown","that","both","activating","regions","of","Oct-2a",",","isolated","from","their","natural","context",",","can","activate","transcription","as","promoter","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"12206","tokens":["Using","Wp","reporter","constructs","in","in","vitro","transfection","assays",",","we","found","that","Wp","was","11-","to","190-fold","more","active","in","B","cell","than","in","non-B","cell","lines","and","that","three","regions","of","the","promoter","(","termed","UAS1",",","UAS2",",","and","UAS3",")","contributed","to","transcriptional","activation","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,5,6,6,0,0,0,0,0,0,1,0,0,1,0,1,0,0,1,0,0,0,0,0,0]}
{"id":"15580","tokens":["Here","we","report","that","LTB4","induces","synthesis","of","interleukin","(","IL",")","-6","by","human","blood","monocytes","through","transcriptional","activation","of","the","IL-6","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,10,0,7,8,8,0,0,0,0,0,1,2,0]}
{"id":"5531","tokens":["We","have","focused","on","the","study","of","the","signal","transduction","pathways","triggered","by","CD23","in","human","monocytes","and","the","promonocytic","cell","line","U937","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,7,8,0,0,5,6,6,6,0]}
{"id":"9531","tokens":["Flow","cytometry","analysis","indicated","that","these","cells","were","expressing","high","levels","of","vascular","cell","adhesion","molecule","1","(","VCAM-1","[","CD106","]",")",",","a","110-kDa","member","of","the","immunoglobulin","gene","superfamily",",","first","identified","on","endothelial","cells","stimulated","with","inflammatory","cytokines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,9,0,9,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,7,8,0,0,9,10,0]}
{"id":"7479","tokens":["--","Vegeto",",","E.",",","Pollio",",","G.",",","Pellicciari",",","C.",",","Maggi",",","A","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2030","tokens":["Similarly",",","Jurkat","T","cell","lines","deficient","in","CD3","or","CD45","expression","also","gave","impaired","UV","responses","."],"ner_tags":[0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11204","tokens":["In","earlier","studies",",","we","have","identified","the","transcription","factors","NF-kappa","B","and","AP-1","as","molecular","targets","for","oxidative","signalling","processes","during","cell","cycle","entry",",","and","have","shown","that","oxidative","signalling","is","involved","in","the","regulation","of","early","changes","in","gene","expression","during","the","G0","to","G1","phase","transition","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4257","tokens":["We","show","here","that","the","plasma","cell-specific","repressor","function",",","designated","SIR","(","suppressor","of","immune","response","genes",")",",","does","not","act","directly","on","the","transcription","of","class","II","genes",",","but","instead","on","the","transcription","of","the","AIR-1","gene",",","whose","product",",","the","class","II","transactivator","(","CIITA",")",",","is","fundamental","for","the","regulation","of","the","constitutive","and","inducible","expression","of","MHC","class","II","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,0,1,2,2,2,2,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"10188","tokens":["To","determine","whether","the","DM","genes","are","regulated","in","a","similar","manner","as","class","II","genes",",","a","series","of","in","vivo","and","in","vitro","analyses","was","performed","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7296","tokens":["The","mechanisms","by","which","GATA-1","controls","cell","survival","are","unknown","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0]}
{"id":"3353","tokens":["The","Pan","gene","encodes","at","least","two","distinct","transcripts",",","Pan-1","and","Pan-2","(","also","known","as","E47","and","E12",",","respectively",")",",","by","the","mechanism","of","alternative","RNA","splicing","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,9,0,9,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4012","tokens":["For","all","other","arginine","mutations",",","no","differences","in","affinity","were","detectable","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3023","tokens":["Immunohistochemical","techniques","were","used","to","demonstrate","that","SP140","localized","to","the","NB","in","differentiated","HL60","and","NB4","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,5,0,5,6,0]}
{"id":"16999","tokens":["An","in","vitro","effect","of","aldosterone","on","intracellular","sodium",",","potassium","and","calcium","concentrations","and","cell","volume","was","shown","in","human","mononuclear","leukocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"3440","tokens":["The","process","of","activation","involves","calcium","mobilization",",","activation","of","protein","kinase","C","(","PKC",")",",","and","phosphorylation","of","tyrosine","kinases","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,9,10,0]}
{"id":"7205","tokens":["SOCS-3","is","tyrosine","phosphorylated","in","response","to","interleukin-2","and","suppresses","STAT5","phosphorylation","and","lymphocyte","proliferation","."],"ner_tags":[9,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0]}
{"id":"11127","tokens":["The","human","TF","promoter","contains","binding","sites","for","the","transcription","factors","AP-1",",","c-Rel\/p65",",","Egr-1",",","and","Sp1","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,9,0,9,0,9,0,0,9,0]}
{"id":"14648","tokens":["Co-expression","of","both","PU.1","and","Ets-1","in","nonlymphoid","cells","trans-activated","reporter","plasmids","that","contained","the","minimal","mu","enhancer","."],"ner_tags":[0,0,0,9,0,9,0,7,8,1,2,2,0,0,0,0,1,2,0]}
{"id":"14637","tokens":["All","groups","contain","cysteine-","and","histidine-rich","putative","zinc","finger","domains","and","a","serine-phenylalanine","``","SFS","''","domain","similar","to","part","of","the","large","subunit","of","eukaryotic","RNA","polymerase","II","."],"ner_tags":[0,0,0,9,10,10,10,10,10,10,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"5323","tokens":["Thus",",","the","ability","of","HIV-1","replication","to","activate","NF-kappaB","is","crucial","to","the","intense","self-perpetuated","viral","transcription","observed","in","cells","of","the","monocytic","lineage","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"1743","tokens":["Expressed","in","the","cytoplasm","or","on","the","cell","surface",",","the","chimera","inhibited","or","activated","early","signaling","events","from","the","T","cell","antigen","receptor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"12061","tokens":["Furthermore",",","recombinant","TIMP-1",",","but","not","TIMP-2","or","a","synthetic","metalloproteinase","inhibitor","(","BB-94",")",",","confers","resistance","to","apoptosis","induced","by","both","CD95-dependent","and","-independent","(","cold","shock",",","serum","deprivation",",","and","gamma-radiation",")","pathways","in","TIMP-1-negative","BL","lines","."],"ner_tags":[0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"11654","tokens":["Upon","antigen","stimulation",",","precursor","CD4+","T","helper","(","pTh",")","cells","proliferate","and","differentiate","into","two","populations","of","effector","cells","(","eTh1","and","eTh2",")",",","each","one","expressing","a","specific","pattern","of","cytokines","that","distinguishes","them","from","their","precursors","."],"ner_tags":[0,0,0,0,0,7,8,8,8,8,8,8,0,0,0,0,0,0,0,7,8,0,7,0,7,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"5919","tokens":["These","perivascular","DC","migrate","across","the","activated","endothelium","from","blood","and","receive","differentiative","signals","within","the","joint","from","monocyte-derived","cytokines","and","CD40-ligand+","T","cells","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,8,8,0]}
{"id":"2002","tokens":["Two","nuclear","factor","NF-IL6","(","positions","-153","to","-145","and","-83","to","-75",")","and","one","nuclear","factor","NF-kappa","B","(","positions","-72","to","-63",")","motifs","are","present","within","this","fragment","."],"ner_tags":[0,9,10,10,0,0,1,2,2,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0,0,0,0,0,0]}
{"id":"16679","tokens":["TCF-1","belonged","to","a","novel","family","of","genes","that","contain","the","so-called","high","mobility","group","1","(","HMG",")","box","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,0]}
{"id":"10069","tokens":["The","JAK","(","Janus","kinase",")","family","of","protein","tyrosine","kinases","and","the","STATs","(","signal","transducers","and","activators","of","transcription",")","have","been","shown","to","be","activated","in","response","to","a","number","of","cytokines","and","growth","factors","."],"ner_tags":[0,9,10,10,10,10,10,0,9,10,10,0,0,9,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0]}
{"id":"7630","tokens":["METHOD","OF","STUDY",":","For","assessment","of","IL","production",",","whole","peripheral","venous","blood","from","healthy","donors","was","stimulated","with","phorbol-myristate-acetate","and","ionomycine","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3272","tokens":["Repeated","cold-air","exposures","increase","human","triiodothyronine","(","T3",")","plasma","clearance","rates","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1798","tokens":["By","Southern","hybridization","analyses","of","somatic","cell","hybrid","panels","with","murine","cDNA","probe",",","fluorescence","chromosomal","in","situ","hybridization","(","FISH",")","of","human","genomic","clones",",","and","analysis","of","recombinant","inbred","mouse","strains",",","we","have","found","single","sites","for","EBF","homologous","sequences","on","human","Chromosome","(","Chr",")","5",",","band","q34",",","and","on","proximal","mouse","Chr","11",",","in","an","evolutionarily","conserved","region","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,2,2,0,0,0,1,2,2,0]}
{"id":"4689","tokens":["This","structural","and","functional","complementarity","for","residue","57","and","a","specific","peptide","residue","identifies","this","interaction","as","a","key","controlling","determinant","of","restricted","recognition","in","HLA-DQ-specific","immune","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16746","tokens":["Starting","with","a","replication-incompetent","molecular","clone","of","human","immunodeficiency","virus","type","1",",","lacking","all","the","NF-kappa","B","and","Sp1","binding","sites","present","in","the","native","long","terminal","repeat","(","LTR",")",",","proviruses","containing","reconstructed","LTRs","with","individual","or","combinations","of","NF-kappa","B","and","Sp1","elements","were","generated","and","evaluated","for","their","capacity","to","produce","virus","progeny","following","transfection-cocultivation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,1,2,2,2,0,1,0,0,0,0,1,2,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4596","tokens":["TNF-alpha","mRNA","and","release","was","inhibited","even","if","IL-10","was","added","up","to","8","h","after","cryptococcal","stimulation","."],"ner_tags":[3,4,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"9448","tokens":["Nonresponders","had","a","significant","increase","both","in","the","number","of","binding","sites","and","in","the","apparent","dissociation","constant","compared","with","responders","(","P","=","0.045",";","P","=","0.029",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4015","tokens":["In","addition",",","antagonists","show","distinctly","different","requirements","for","efficient","binding",",","which","may","contribute","to","their","interference","in","the","ligand-inducible","transactivation","function","of","RAR","alpha","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"12194","tokens":["Butyric","acid","(","BA",")","is","known","to","induce","overexpression","of","fetal","hemoglobin","and","then","erythroid","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"16267","tokens":["Steady-state","levels","of","1",",","25","(","OH",")","2D3","receptor","RNA","were","not","affected","by","terminal","differentiation","of","HL-60","toward","either","granulocytes","or","macrophages","."],"ner_tags":[0,0,0,3,4,4,4,4,4,4,4,4,0,0,0,0,0,0,0,5,0,0,7,0,7,0]}
{"id":"8118","tokens":["The","nuclear","pool","of","I","(","kappa",")","B","(","alpha",")","showed","a","higher","stability","than","cytosolic","I","(","kappa",")","B","(","alpha",")","and","was","partially","independent","of","the","resynthesis","of","the","protein","."],"ner_tags":[0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9801","tokens":["CD30","is","a","cell-surface","receptor","that","can","augment","lymphocyte","activation","and","survival","through","its","ability","to","induce","the","transcription","factor","NF-kappaB","."],"ner_tags":[9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,9,0]}
{"id":"3366","tokens":["Thus",",","we","focused","our","study","on","isolated","FDC","clusters","from","normal","tonsils","."],"ner_tags":[0,0,0,0,0,0,0,0,7,0,0,0,0,0]}
{"id":"7240","tokens":["Both","alpha-","and","beta-bound","complexes","are","found","only","in","lymphoid","tissues",",","in","CD28+","T","cells",",","and","in","some","transformed","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,5,6,6,0]}
{"id":"9434","tokens":["However",",","amino","acids","207","to","368","are","dispensable","when","the","protein","is","bound","to","DNA","as","a","fusion","with","the","GAL4","DBD",",","thus","implicating","this","region","in","DNA","binding","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"10665","tokens":["RFX5","and","CIITA","associate","to","form","a","complex","capable","of","activating","transcription","from","class","II","major","histocompatibility","complex","promoters","."],"ner_tags":[9,0,9,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,0]}
{"id":"1619","tokens":["The","mechanism","of","transactivation","by","BMLF1","proteins","has","been","controversial","but","SM","was","shown","to","transactivate","gene","expression","from","a","CAT","reporter","construct","by","increasing","the","amount","of","cytoplasmic","CAT","mRNA","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,3,4,4,0]}
{"id":"10950","tokens":["In","several","cases",",","the","peptide","epitope","and","HLA-restricting","determinant","recognized","by","these","CTLs","has","been","defined",",","one","unusual","feature","being","the","number","of","responses","restricted","through","HLA-C","alleles","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"7412","tokens":["Together",",","these","findings","suggest","that","LITAF","plays","an","important","role","in","the","activation","of","the","human","TNF-alpha","gene","and","proposes","a","new","mechanism","to","control","TNF-alpha","gene","expression","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"4904","tokens":["In","view","of","these","findings",",","we","analyzed","the","effects","of","IFN-gamma","on","the","expression","of","different","transcription","factors","in","activated","human","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,0,0,7,8,0]}
{"id":"3922","tokens":["Cloning","and","characterization","of","the","beta","subunit","of","human","proximal","sequence","element-binding","transcription","factor","and","its","involvement","in","transcription","of","small","nuclear","RNA","genes","by","RNA","polymerases","II","and","III","."],"ner_tags":[0,0,0,0,0,9,10,0,9,10,10,10,10,10,0,0,0,0,0,0,1,2,2,2,0,9,10,10,10,10,0]}
{"id":"4622","tokens":["The","cytoplasmic","domain","of","the","receptor","for","interleukin","10","(","IL-10R",")","contains","two","box","3","sequence","motifs","that","have","been","identified","in","the","signal-transducing","receptor","subunits","for","IL-6-type","cytokines","and","noted","to","be","required","for","activating","STAT3","and","inducing","transcription","through","IL-6-responsive","elements","."],"ner_tags":[0,9,10,0,0,0,0,9,10,0,9,0,0,0,9,10,10,10,0,0,0,0,0,0,9,10,10,0,9,10,0,0,0,0,0,0,0,9,0,0,0,0,1,2,0]}
{"id":"5342","tokens":["These","results","indicate","that","mitogenic","combinations","of","T","cell","activation","signals","are","integrated","at","the","level","of","NF-MATp35","induction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"7617","tokens":["CONCLUSION",":","The","results","in","this","study","confirm","the","potency","of","the","inhaled","corticosteroid","FP","and","provide","evidence","for","a","considerable","tissue-specific","interindividual","variation","in","the","expression","of","the","GR","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"5673","tokens":["This","may","imply","a","role","for","ets","transcription","factors","in","the","production","of","TNF-alpha","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0,0,9,0]}
{"id":"10205","tokens":["Structure","and","function","analysis","of","the","human","myeloid","cell","nuclear","differentiation","antigen","promoter",":","evidence","for","the","role","of","Sp1","and","not","of","c-Myb","or","PU.1","in","myelomonocytic","lineage-specific","expression","."],"ner_tags":[0,0,0,0,0,0,1,2,2,2,2,2,2,0,0,0,0,0,0,9,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"3584","tokens":["Bcd","transcripts","were","detected","in","all","normal","PBL","samples","tested","but","not","in","several","malignant","human","B-cell","lines","and","not","in","50","%","of","B-cells","from","B-CLL","patients","."],"ner_tags":[1,0,0,0,0,0,0,7,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,7,0,0,0,0]}
{"id":"11527","tokens":["This","identification",",","initially","made","by","microsequence","analysis",",","was","verified","by","showing","that","(","i",")","LR1","-DNA","binding","activity","increased","in","B","cells","transfected","with","a","nucleolin","cDNA","expression","construct",";","(","ii",")","LR1","-DNA","binding","activity","was","recognized","by","antibodies","raised","against","recombinant","human","nucleolin",";","and","(","iii",")","in","B","cells","transfected","with","epitope-tagged","nucleolin","expression","constructs",",","the","LR1-DNA","complex","was","recognized","by","the","anti-tag","antibody","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,8,0,0,0,1,2,2,2,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,7,8,0,0,1,2,2,2,0,0,9,10,0,0,0,0,9,10,0]}
{"id":"7259","tokens":["In","a","model","where","foreign","cells","(","rat","fibroblasts",")","were","cocultured","with","human","IL-2","activated","NK","cells",",","we","observed","that","NK","cells","were","capable","of","efficiently","killing","their","targets","only","if","the","cells","overexpressed","the","oncogene","c-Myc","or","E1A","."],"ner_tags":[0,0,0,0,7,8,0,7,8,0,0,0,0,7,8,8,8,8,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"376","tokens":["However",",","upon","stable","integration","into","chromatin",",","deletion","of","this","region","causes","a","nearly","90","%","decrease","in","promoter","activity","compared","with","expression","from","an","alpha-globin","promoter","retaining","this","region","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"16306","tokens":["The","gene","contains","a","CpG-rich","island","suggesting","expression","in","the","germ","line","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"14590","tokens":["We","find","that","a","short","enhancer","element","containing","the","NF-kappa","B","binding","site","from","the","interleukin-2","receptor","alpha-chain","gene","(","IL-2R","alpha",")","is","preferentially","activated","in","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,1,2,2,2,0,9,10,0,0,0,0,0,7,8,0]}
{"id":"16557","tokens":["Increased","levels","of","membrane-associated","PKC","activity","persisted","until","17-29","days","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0]}
{"id":"12312","tokens":["The","magnitude","of","responsiveness","is","cell","type","dependent","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"8481","tokens":["Furthermore",",","addition","of","the","recombinant","NF-Y","A","subunit","restores","NF-Y","binding","."],"ner_tags":[0,0,0,0,0,0,9,9,10,0,9,0,0]}
{"id":"8142","tokens":["However",",","the","cellular","signaling","pathway","(","s",")","caused","by","hypoxia","is","poorly","understood","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3154","tokens":["SDS-PAGE","analysis","of","the","receptor","protein","has","shown","a","molecular","weight","of","approximately","50","kD","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"16114","tokens":["The","transcription","factor","GATA-1","is","expressed","in","a","subset","of","hemopoietic","cells",",","where","it","mediates","the","cell-type","specific","expression","of","several","genes","."],"ner_tags":[0,9,10,9,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16875","tokens":["NF-E1","expression","seems","to","be","restricted","to","the","erythrocytic","lineage","."],"ner_tags":[9,0,0,0,0,0,0,0,7,8,0]}
{"id":"5510","tokens":["STATs","hereafter","are","translocated","to","the","nucleus","where","they","act","as","transcription","factors","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"6843","tokens":["We","now","demonstrate","that","parasite-induced","NF-kappaB","activation","plays","a","crucial","role","in","the","survival","of","T.","parva-transformed","T","cells","by","conveying","protection","against","an","apoptotic","signal","that","accompanies","parasite-mediated","transformation","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16318","tokens":["These","results","suggest","that","HIV-TF1","is","involved","in","transcriptional","regulation","of","HIV-1","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"17134","tokens":["It","appears","that","the","B","cell-specific","expression","of","Ig","genes","is","mediated","at","least","in","part","by","cell","type-specific","Oct","factors",",","and","that","there","are","both","quantitative","and","qualitative","differences","between","Oct-1","and","Oct-2","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0]}
{"id":"7892","tokens":["Interestingly",",","it","was","shown","that","NF-kappa","B","-mediated","gene","transcription",",","both","in","the","context","of","the","IL-6","promoter","as","well","as","on","its","own",",","was","dependent","on","both","serine","kinase","activity","and","interaction","with","c-Jun","protein","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"13534","tokens":["Class","II","transactivator-independent","endothelial","cell","MHC","class","II","gene","activation","induced","by","lymphocyte","adhesion","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"18098","tokens":["Prolactin","and","interleukin-2","receptors","in","T","lymphocytes","signal","through","a","MGF-STAT5-like","transcription","factor","."],"ner_tags":[9,0,9,10,0,7,8,0,0,0,9,10,10,0]}
{"id":"2645","tokens":["Tat-binding","protein","7","is","a","subunit","of","the","26S","protease","."],"ner_tags":[9,10,10,0,0,0,0,0,9,10,0]}
{"id":"8265","tokens":["Furthermore",",","the","SH2-deleted","Grf40","mutant","led","to","a","marked","inhibition","of","these","regulatory","activities",",","the","effect","of","which","is","apparently","stronger","than","that","of","the","SH2-deleted","Grb2","mutant","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"8072","tokens":["Interfollicular","cells","are","negative","for","Bcl-6","protein",",","except","for","rare","CD3+\/CD4+","T","cells","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,7,8,8,0]}
{"id":"15962","tokens":["The","MAD-3","cDNA","encodes","an","I","kappa","B-like","protein","that","is","likely","to","be","involved","in","regulation","of","transcriptional","responses","to","NF-kappa","B",",","including","adhesion-dependent","pathways","of","monocyte","activation","."],"ner_tags":[0,1,2,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"4515","tokens":["Impaired","myelopoiesis","in","vivo","was","shown","by","stressing","these","mice","with","sublethal","irradiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13148","tokens":["In","situ","DNA","binding","assay","determined","Stat3","activation","predominantly","within","alveoli","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"2893","tokens":["We","thus","conclude","that","PTPases","play","a","crucial","role","in","the","negative","regulation","of","signal","transduction","culminating","in","T-lymphocyte","activation","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0]}
{"id":"5161","tokens":["META","(","D+",")","directed","transcription","of","a","linked","luciferase","gene",",","and","gel","shift","analysis","revealed","binding","of","inducible",",","CsA-sensitive","T","cell","factors",",","in","parallel","with","transfection","results","."],"ner_tags":[1,2,2,2,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0]}
{"id":"7533","tokens":["We","also","show","that","this","mechanism","may","play","a","fundamental","role","in","the","persistence","of","T","cells","at","sites","of","chronic","inflammation",";","suggesting","that","chronic","inflammation","is","an","aberrant","consequence","of","immunological","memory","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12246","tokens":["Membrane-associated","lymphotoxin","on","natural","killer","cells","activates","endothelial","cells","via","an","NF-kappaB","-dependent","pathway","."],"ner_tags":[9,10,0,7,8,8,0,7,8,0,0,9,0,0,0]}
{"id":"10936","tokens":["Throughout","the","study","period",",","CD41","immunofluorescence","of","leukocytes","(","flow","cytometry",")","revealed","increased","leukocyte-platelet","adhesion","in","patients","with","AMI","compared","with","control","patients","(","mean","+\/-","SE","of","fluorescence","[","channels","]","before","PTCA",":","77","+\/-","16","versus","35","+\/-","9",";","P","=",".003",")","."],"ner_tags":[0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13764","tokens":["We","recently","determined","that","erythropoietin","(","EPO",")","activates","3","members","of","the","signal","transducer","and","activator","of","transcription","(","STAT",")","family",",","Stat1alpha",",","Stat3",",","and","Stat5",",","in","the","human","EPO-dependent","cell","lines",",","UT-7","and","UT-7\/EPO","(","Kirito","et","al",",","J","Biol","Chem","272",":","16507",",","1997",")","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,0,0,0,5,6,6,6,0,5,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2972","tokens":["Among","these","properties","are","NF-kappa","B","'s","rapid","posttranslational","activation","in","response","to","many","pathogenic","signals",",","its","direct","participation","in","cytoplasmic\/nuclear","signaling",",","and","its","potency","to","activate","transcription","of","a","great","variety","of","genes","encoding","immunologically","relevant","proteins","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"1286","tokens":["An","insulin","tolerance","test","(","ITT",")","was","performed","at","the","end","of","the","second","week","of","treatment","and","at","the","end","of","the","6-week","washout","period","with","no","statistically","significant","change","in","cortisol","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10863","tokens":["Elf-1","is","a","lymphoid-specific","transcription","factor","that","belongs","to","the","ETS","protein","family","."],"ner_tags":[9,0,0,9,10,10,0,0,0,0,9,10,10,0]}
{"id":"830","tokens":["This","locus","is","rearranged","by","chromosomal","translocations","in","human","myeloproliferative","disorders","and","leukemias","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1130","tokens":["Human","RAR","alpha","was","expressed","in","H9",",","U937","and","THP-1","cells",",","but","almost","undetectable","in","CEM","cells","."],"ner_tags":[9,10,10,0,0,0,5,0,5,0,5,6,0,0,0,0,0,5,6,0]}
{"id":"5682","tokens":["Furthermore",",","significant","apoptosis","was","observed","in","transgenic","megakaryocytes","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0]}
{"id":"773","tokens":["Direct","sequencing","of","the","viral","genomes","and","reinfection","kinetics","showed","no","evidence","of","wild-type","reversion","even","after","prolonged","infection","with","the","Tat","-virus","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"17769","tokens":["In","human","peripheral","blood","mononuclear","cells","(","PBMC",")","stimulated","with","OKT3\/PMA",",","tepoxalin","inhibited","lymphocyte","proliferation","with","an","IC50","of","6","microM","."],"ner_tags":[0,7,8,8,8,8,0,7,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0]}
{"id":"16890","tokens":["Oestrogen","receptors","(","ER",")","are","present","in","neoplastic","lymphoid","cells","and","have","been","considered","a","physiological","marker","of","growth","rate","or","differentiation","."],"ner_tags":[9,10,0,9,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4078","tokens":["Electrophoretic","mobility","shift","assay","showed","that","each","of","the","cis-elements","bound","specific","protein","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,0,0,9,10,0]}
{"id":"11379","tokens":["Cell-to-cell","contact","activates","the","long","terminal","repeat","of","human","immunodeficiency","virus","1","through","its","kappaB","motif","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,0,0,1,2,0]}
{"id":"14268","tokens":["These","are",":","helper-inducer","(","memory",")","T","cells","(","CD4+CD45R0+CD45RA-CD29highCD11a+",")",",","CD20+","B","cells",",","and","cytotoxic","T","cells","(","CD8+CD56+\/CD57+",")","."],"ner_tags":[0,0,0,7,8,8,8,8,8,0,7,0,0,7,8,8,0,0,7,8,8,0,7,0,0]}
{"id":"1466","tokens":["At","variance",",","the","second","peak","which","has","never","been","reported","previously",",","lasted","several","hours","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11192","tokens":["The","model","should","be","useful","for","exploring","the","molecular","pathogenesis","of","APL","and","the","mechanisms","of","the","therapeutic","response","to","retinoic","acid",",","as","well","as","for","preclinical","studies","of","therapeutic","regimens","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16164","tokens":["However",",","these","genes","are","not","constitutively","active","in","B","lymphocytes",",","suggesting","that","other","regulatory","mechanisms","must","play","a","role","in","determining","the","patterns","of","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8782","tokens":["After","obtaining","the","patients","'","informed","consent",",","biopsies","were","performed","before","treatment","and","at","doses","of","4",",","10",",","and","20","Gy","of","radiotherapy",",","and","the","specimens","were","preserved","in","liquid","nitrogen","for","further","examination","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6252","tokens":["Expression","of","luciferase","in","these","cells","was","induced","by","phorbol","myristate","acetate","plus","a","calcium","ionophore","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7182","tokens":["CTLA-4","engagement","by","mAbs","inhibits",",","while","CD28","enhances",",","IL-2","production","and","proliferation","upon","T","cell","activation","."],"ner_tags":[9,0,0,9,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"10979","tokens":["RP1",",","a","new","member","of","the","adenomatous","polyposis","coli-binding","EB1-like","gene","family",",","is","differentially","expressed","in","activated","T","cells","."],"ner_tags":[1,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,7,8,8,0]}
{"id":"15538","tokens":["However",",","CsA","and","FK506","inhibit","the","appearance","of","DNA","binding","activity","of","factors","that","bind","to","the","NF-AT","and","AP-1","sites","in","the","IL-2","enhancer","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,2,0,0,1,2,0]}
{"id":"11117","tokens":["Our","data","suggest","that","the","c-fos","upregulation","mediated","by","Tat","might","play","a","significant","role","in","the","control","of","viral","gene","transactivation","."],"ner_tags":[0,0,0,0,0,1,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10355","tokens":["Prolactin","activates","Stat5",",","and","interleukin-4","(","IL-4",")","activates","Stat6","."],"ner_tags":[0,0,9,0,0,9,0,9,0,0,9,0]}
{"id":"1692","tokens":["In","the","intron",",","further","transcription","factor","binding","sites",",","including","a","NF-kappa","B","element",",","were","identified","leading","to","the","suggestion","that","the","expression","of","the","gene","encoding","for","the","nuclear","autoantigen","La\/SS-B","alters","in","dependence","on","disease","conditions","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"4766","tokens":["IL-12","is","a","novel","heterodimeric","cytokine","important","for","the","regulation","and","differentiation","of","lymphocytes","and","NK","cells","."],"ner_tags":[9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1094","tokens":["In","this","study","the","effects","of","HIV","protease","on","NF-kappa","B","precursor","activation","were","examined","in","Jurkat","T","cells","by","introducing","a","protease","expression","vector","into","the","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,7,8,0,0,0,1,2,2,0,0,0,0]}
{"id":"8190","tokens":["RA","-triggered","GALdbd-","RARalpha","hybrid","activity","in","these","cells","indicates","that","the","multipotent","EML","cells","harbor","substantial","nuclear","hormone","receptor","coactivator","activity","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,9,0,0]}
{"id":"3325","tokens":["Rheumatoid","arthritis","is","a","multistep","disorder","associated","with","autoimmune","features","of","yet","unknown","etiology","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18064","tokens":["TCL1","oncogene","activation","in","preleukemic","T","cells","from","a","case","of","ataxia-telangiectasia","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,0,0,0]}
{"id":"8886","tokens":["Promoter","sequence",",","exon",":","intron","structure",",","and","synteny","of","genetic","location","show","that","a","chicken","cytokine","with","T-cell","proliferative","activity","is","IL2","and","not","IL15","."],"ner_tags":[1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,0,0,9,0]}
{"id":"4211","tokens":["In","contrast",",","in","DOX-treated","cells",",","the","transcription","rate","of","these","genes","was","unchanged","in","comparison","with","control","cells","."],"ner_tags":[0,0,0,0,5,6,0,0,0,0,0,0,1,0,0,0,0,0,7,8,0]}
{"id":"1338","tokens":["The","differentiating","agent","retinoic","acid","(","RA",")","has","been","previously","reported","to","interfere","with","12-O-tetradecanoyl-phorbol-13-acetate","(","TPA",")","\/Ca","(","2+",")","-induced","signals","for","the","regulation","of","the","-96","to","-66-bp","octamer","motif","found","in","the","enhancer","for","the","interleukin","(","IL",")","-2","gene",",","which","encodes","a","major","T","lymphocyte","growth","factor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,9,10,10,10,0]}
{"id":"11409","tokens":["We","have","set","out","to","test","a","model","for","tissue-specific","gene","expression","that","relies","on","the","early","replication","of","expressed","genes","to","sequester","limiting","activating","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"7292","tokens":["Although","statistical","evaluation","of","the","data","showed","a","significant","difference","between","patients","with","a","chronic","MPD","and","control","subjects",",","proof","of","clonality","in","individual",",","especially","elderly",",","patients","is","difficult","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1023","tokens":["A","new","protein-DNA","interaction","has","been","identified","upstream","of","the","intron","enhancer",",","within","the","matrix-associated","region","of","the","J-C","intron","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,0,0,1,2,0]}
{"id":"4120","tokens":["While","one","of","the","twins","was","clinically","affected",",","the","other","was","asymptomatic","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11703","tokens":["Isoforms","Pax-5d","and","Pax-5e","have","deleted","the","3'-region",",","which","encodes","the","transactivating","domain",",","and","replaced","it","with","a","novel","sequence","."],"ner_tags":[0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9945","tokens":["In","most","cells",",","Rel\/NF-kappa","B","transcription","factors","appear","to","mediate","survival","signals","that","protect","cells","from","apoptosis",";","however",",","under","some","circumstances",",","activation","of","these","factors","may","also","promote","apoptosis","."],"ner_tags":[0,0,0,0,9,10,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10403","tokens":["We","have","examined","the","5'-regulatory","sequences","that","are","important","for","the","transcriptional","regulation","of","this","gene","in","T","cells","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"9458","tokens":["IgE","germline","promoter","reporter","gene","constructs","carrying","point","mutations","in","the","NF","kappa","B2","site","were","largely","unresponsive","to","IL-4","stimulation","in","transient","transfection","experiments",",","while","plasmids","with","similar","mutations","in","the","NF","kappa","B1","site","responded","to","cytokine","stimulation","better","than","the","wild-type","promoter","."],"ner_tags":[1,2,2,2,2,2,0,0,0,0,0,9,10,10,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,9,0,0,0,0,1,2,0]}
{"id":"14972","tokens":["The","recombinant","polypeptide","formed","sequence-specific","complexes","with","the","EBF-binding","site","in","the","mb-1","promoter","."],"ner_tags":[0,9,10,0,0,0,0,0,1,2,0,0,1,2,0]}
{"id":"16380","tokens":["This","absence","of","binding","was","localized","to","the","NF-kappa","B","region","of","the","HIV-1","enhancer",";","the","65-kDa","plus","50-kDa","NF-kappa","B","heterodimer","was","preferentially","lost","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,0,0,9,10,10,10,10,10,0,0,0,0]}
{"id":"15921","tokens":["Now","we","have","examined","the","effect","of","the","nature","of","the","monocyte","activating","signal","on","these","two","inhibitory","mechanims","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13061","tokens":["To","investigate","processes","related","to","B","and","T","cell","activation",",","the","gene","expression","of","stimulated","and","nonstimulated","Ramos","and","Jurkat","cells","was","studied","using","cDNA","microarray","technology","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,0,0,0,0,0,0,0]}
{"id":"13309","tokens":["AR","protein","decreased","by","70","%","and","PSA","levels","in","supernatants","from","LNCaP","cells","were","reduced","by","approximately","80","%","following","treatment","with","MCM","."],"ner_tags":[9,10,0,0,0,0,0,9,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17358","tokens":["The","sexual","difference","in","the","incidence","of","autoimmune","diseases","has","remained","an","enigma","for","many","years","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6873","tokens":["The","LY294002","study","showed","that","proliferation","and","viability","of","both","HCD57-SREI","and","HCD57","cells","correlated","with","the","activity","of","PKB\/Akt",";","however",",","PKB\/Akt","activity","alone","did","not","protect","these","cells","from","apoptosis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,0,5,6,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"17204","tokens":["The","enhancer","consists","of","tandem","AP-1-binding","sites",",","phased","10","bp","apart",",","which","are","both","required","for","full","activity","."],"ner_tags":[0,1,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5911","tokens":["Induced","MIP-1alpha","expression","and","secretion","in","PMA\/PHA","stimulated","tax","transfected","cells","correlate","with","the","noninduction","of","MNP-1","transcription","factor",",","which","is","intimately","involved","in","downmodulating","the","MIP-1alpha","gene","."],"ner_tags":[0,9,0,0,0,0,5,6,6,6,6,0,0,0,0,0,9,9,10,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"30","tokens":["Ligand-dependent","repression","of","the","erythroid","transcription","factor","GATA-1","by","the","estrogen","receptor","."],"ner_tags":[0,0,0,0,9,10,10,9,0,0,9,10,0]}
{"id":"13651","tokens":["Differential","regulation","of","coproporphyrinogen","oxidase","gene","between","erythroid","and","nonerythroid","cells","."],"ner_tags":[0,0,0,1,2,2,0,7,8,8,8,0]}
{"id":"17943","tokens":["Sequencing","revealed","a","different","mutation","on","each","allele",":","a","single","nucleotide","insertion","resulting","in","a","frame","shift","and","premature","termination","in","the","Jak3","JH4","domain","and","a","nonsense","mutation","in","the","Jak3","JH2","domain","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,9,0,0,0]}
{"id":"3466","tokens":["Inhibition","of","membrane","IL-2R","alpha","and","IL-2R","beta","expression","by","10","(","-6",")","M","DM","was","partially","reversible","by","recombinant","human","IL-2","(","rhIL-2",")","."],"ner_tags":[0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"8619","tokens":["These","results","suggest","that","the","NF-kappaB","binding","site","located","around","120","bp","upstream","of","the","transcription","initiation","site","in","murine","and","human","p40","promoter","regions","could","be","important","for","the","p40","induction","by","CD40","ligation","via","activation","of","NF-kappaB","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,1,2,2,0,1,2,2,2,2,2,0,0,0,0,0,9,0,0,9,0,0,0,0,9,0]}
{"id":"18128","tokens":["Although","the","mean","hTR","beta","1","mRNA","levels","were","40","%","lower","in","hyperthyroid","than","in","euthyroid","subjects",",","this","difference","did","not","reach","statistical","significance","."],"ner_tags":[0,0,0,3,4,4,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12489","tokens":["In","this","study","three","novel","clones","were","constructed","in","which","the","ZEBRA","activation","region","was","repositioned","to","the","carboxy","terminus","of","the","protein","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,9,10,0,0,0,0]}
{"id":"12083","tokens":["During","the","differentiation","process","of","cells","from","the","monocytic","cell","line","THP-1","we","observed","a","transient","transcriptional","upregulation","of","a","human","carboxylesterase","analyzed","by","means","of","Northern","blots","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"8104","tokens":["Previous","characterization","of","the","GPIX","promoter","identified","a","functional","Ets","site","that",",","when","disrupted",",","reduced","promoter","activity","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8138","tokens":["We","conclude","the","FECa2+","and","the","Vmax","of","the","SERCA","are","reliable","indicators","of","Ca2+","load","in","platelets","from","women","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,7,0,0,0]}
{"id":"5648","tokens":["In","this","study",",","we","analyzed","the","binding","activity","of","IL-10-","and","IFN-gamma-activated","STAT","molecules","to","two","kinds","of","GAS","-motif","sequences","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,1,0,0,0]}
{"id":"17062","tokens":["These","findings","suggested","that","the","increase","in","c-jun","RNA","observed","during","TPA-induced","monocytic","differentiation","is","mediated","by","both","transcriptional","and","post-transcriptional","mechanisms","."],"ner_tags":[0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18342","tokens":["Furthermore",",","we","demonstrate","that","in","myeloid","and","B","cell","extracts",",","PU.1","forms","a","novel",",","specific",",","more","slowly","migrating","complex","(","PU-SF",")","when","binding","the","GM-CSF","receptor","alpha","promoter","PU.1","site","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,10,10,0,1,2,0]}
{"id":"14485","tokens":["A","mutation","of","the","glucocorticoid","receptor","in","primary","cortisol","resistance","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0]}
{"id":"11962","tokens":["Unexpectedly",",","the","CD8+","T-cell","subpopulation","failed","to","respond","."],"ner_tags":[0,0,0,7,8,8,0,0,0,0]}
{"id":"7335","tokens":["However",",","we","report","in","vitro","experimental","studies","in","which","IL-10","primed","leukocytes","and","led","to","an","enhanced","production","of","tumor","necrosis","factor","(","TNF",")","upon","further","stimulation","by","lipopolysaccharide","(","LPS",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"14332","tokens":["Thus","the","response","of","K562","cells","to","HMBA","may","provide","a","useful","experimental","system","for","studying","the","molecular","mechanisms","responsible","for","downmodulation","of","lineage-restricted","transcription","factors","during","hemopoietic","lineage","commitment","."],"ner_tags":[0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"7173","tokens":["As2O3","may","prove","useful","in","the","treatment","of","malignant","lymphoproliferative","disorders","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7141","tokens":["Coligation","of","CD28","leads","to","synergistic","enhancement","of","IL-2","secretion","."],"ner_tags":[0,0,9,0,0,0,0,0,9,0,0]}
{"id":"16088","tokens":["Except","for","a","4-hour","advancement","of","the","peak",",","a","similar","circadian","rhythm","of","hepatic","GR","was","detected","in","rats","reared","under","a","reversed","lighting","regimen","(","12D",":","12L",";","lights","on","between","18",":","30","and","06",":","30","h",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11934","tokens":["Stimulation","of","human","neutrophils","with","chemoattractants","FMLP","or","platelet","activating","factor","(","PAF",")","results","in","different","but","overlapping","functional","responses","."],"ner_tags":[0,0,7,8,0,9,9,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"6034","tokens":["Although","the","mutant","strain","was","able","to","kill","HL-60-","and","THP-1-derived","macrophages",",","it","could","not","replicate","within","a","protozoan","host",",","Acanthamoeba","castellanii","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13070","tokens":["Here",",","cytokine","-induced","activation","of","Stat3","in","previously","activated","CD4","(","+",")","human","T","cells","was","examined","using","Stat3","antibodies","directed","against","different","regions","of","Stat3","."],"ner_tags":[0,0,9,0,0,0,9,0,0,0,7,8,8,8,8,8,8,0,0,0,9,0,0,0,0,0,0,9,0]}
{"id":"14798","tokens":["In","addition",",","the","macrophage","transcription","factor","PU.1","binds","the","CD11b","promoter","in","vitro","and","in","vivo","close","to","the","Sp1","site","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"6870","tokens":["To","better","understand","signals","controlling","proliferation","and","viability",",","erythroid","cells","that","resist","apoptosis","in","the","absence","of","EPO","were","subcloned","and","characterized","(","HCD57-SREI","cells",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,5,6,0,0]}
{"id":"4989","tokens":["Since","inappropriate","activation","of","kappa","B-driven","genes","has","a","physiopathologic","role","in","a","number","of","diseases",",","such","as","HIV","infection",",","our","findings","support","the","possibility","of","using","this","cytokine","to","suppress","an","undesirable","activation","of","these","transcription","factors","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"7227","tokens":["The","secondary","lymphoid","tissues","are","located","at","strategic","sites","where","foreign","antigens","can","be","efficiently","brought","together","with","immune","system","regulatory","and","effector","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,7,8,8,8,8,8,0]}
{"id":"9377","tokens":["Further",",","cotransfection","analysis","in","Drosophila","cells","showed","that","Sp3",",","as","was","previously","shown","for","Sp1",",","also","synergizes","with","c-Jun","to","activate","CD11c","."],"ner_tags":[0,0,0,0,0,5,6,0,0,9,0,0,0,0,0,0,9,0,0,0,0,9,0,0,1,0]}
{"id":"16903","tokens":["Competition","analysis","showed","that","the","anti-estrogen","tamoxifen","and","the","flavonoids","quercetin","and","rutin","competed","for","(","3H",")","-E2","binding","to","type-II","EBS","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"5200","tokens":["We","show","that","both","delta383","and","delta99","specifically","enhance","expression","of","cat","for","plasmids","containing","a","human","adult","globin","(","HBB",")","promoter",",","whereas","expression","of","similar","constructs","using","human","fetal","(","A","gamma-",")","globin","(","HBG1",")","or","simian","virus","40","(","SV40",")","promoters","is","not","enhanced","."],"ner_tags":[0,0,0,0,1,0,1,0,0,0,0,9,0,1,0,0,1,2,2,2,2,2,2,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,2,0,0,0,0]}
{"id":"13801","tokens":["In","the","present","study",",","the","role","of","IL-2R","signaling","in","the","growth","of","CD8+","T","cell","prolymphocytic","leukemia","(","T-PLL",")","cells","has","been","investigated","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,5,6,6,6,6,6,6,6,6,0,0,0,0]}
{"id":"1017","tokens":["Using","a","highly","sensitive","mutation","screening","assay","of","the","DNA-","and","the","steroid-binding","region",",","none","of","the","treated","patients","revealed","any","mutation",",","suggesting","that","the","glucocorticoid","receptor","in","the","CLL","patients","tested","is","not","altered","in","these","domains","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12400","tokens":["The","purpose","of","this","study","was","to","determine","the","effect","of","IL-10","on","lipopolysaccharide","(","LPS",")","-induced","human","monocyte","TNF-alpha","production",",","NF-kappaB","activation",",","and","IkappaB-alpha","degradation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,9,0,0]}
{"id":"3297","tokens":["Levels","of","FOSB","mRNA","reach","a","maximum","40","min","after","the","addition","of","lectin","and","decline","to","control","levels","over","the","next","6","hr","."],"ner_tags":[0,0,3,4,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"961","tokens":["Terminal","differentiation","of","B","cells","to","plasma","cells","in","vivo","is","characterized","by","secretion","of","Ig","and","extinction","of","MHC","class","II","expression","on","the","cell","surface","."],"ner_tags":[0,0,0,7,8,0,7,8,0,0,0,0,0,0,0,9,0,0,0,9,10,10,0,0,0,0,0,0]}
{"id":"14920","tokens":["Human","CD4","lymphocytes","specifically","recognize","a","peptide","representing","the","fusion","region","of","the","hybrid","protein","pml\/RAR","alpha","present","in","acute","promyelocytic","leukemia","cells","."],"ner_tags":[7,8,8,0,0,0,0,0,0,0,0,0,0,9,10,9,10,0,0,7,8,8,8,0]}
{"id":"11537","tokens":["The","GC-R","Bmax","and","Kd","in","quiescent","PBMC","of","the","GC-resistant","group","were","5.33","+\/-","1.37","fmol\/10","(","6",")","cells","and","3.20","+\/-","1.39","nM",",","respectively","."],"ner_tags":[0,9,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5506","tokens":["CONCLUSIONS","--","These","observations","indicate","that","there","are","immunophenotypic","correlates","to","the","current","structural","classification","of","IDC","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4894","tokens":["A","variety","of","cytokines","and","growth","factors","act","through","an","induction","of","gene","expression","mediated","by","a","family","of","latent","transcription","factors","called","STAT","(","signal","transducers","and","activators","of","transcription",")","proteins","."],"ner_tags":[0,0,0,9,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,10,10,10,10,10,10,10,10,0]}
{"id":"6975","tokens":["The","method","developed","can","be","adapted","to","characterize","and","identify","other","composite","elements","as","well","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0]}
{"id":"4615","tokens":["Selective","effects","of","DNA","damaging","agents","on","HIV","long","terminal","repeat","activation","and","virus","replication","in","vitro","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0]}
{"id":"852","tokens":["LMP-1","activates","NF-kappa","B","by","targeting","the","inhibitory","molecule","I","kappa","B","alpha","."],"ner_tags":[9,0,9,10,0,0,0,9,10,10,10,10,10,0]}
{"id":"6416","tokens":["However",",","even","the","cells","expressing","very","high","levels","of","exogenous","Bcl-2","eventually","underwent","differentiation","without","a","significant","decrease","in","the","synthesis","of","Bcl-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"6341","tokens":["Analysis","of","DNA","binding","revealed","that","NF-kappa","B","activation","in","response","to","TNF","was","significantly","inhibited","under","these","conditions","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"14744","tokens":["The","E1A","and","hexon","primers","amplified","DNA","from","representative","adenoviral","serotypes","in","all","six","adenoviral","groups","(","A-F",")","."],"ner_tags":[0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13638","tokens":["Here",",","we","report","that","LPS","induces","IKK","activity","in","human","monocytes","and","THP-1","monocytic","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,7,8,0,5,6,6,0]}
{"id":"114","tokens":["Although","removal","of","the","first","67","amino","acids","of","p95vav","activates","its","transforming","potential","in","NIH","3T3","cells",",","this","region","appears","to","be","required","for","its","function","in","T","cells","."],"ner_tags":[0,0,0,0,9,10,10,10,0,9,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"5108","tokens":["Inhibition","of","vitamin","D","receptor-retinoid","X","receptor-vitamin","D","response","element","complex","formation","by","nuclear","extracts","of","vitamin","D-resistant","New","World","primate","cells","."],"ner_tags":[0,0,9,10,10,10,10,10,10,10,10,0,0,0,0,0,7,8,8,8,8,8,0]}
{"id":"7885","tokens":["However",",","binding","of","SHP2","to","SIT","is","not","required","for","inhibition","of","NF-AT","induction",",","suggesting","that","SIT","not","only","regulates","NF-AT","activity","but","also","controls","NF-AT","unrelated","pathways","of","T","cell","activation","involving","SHP2","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"1953","tokens":["Prenatal","immune","challenge","alters","the","hypothalamic-pituitary-adrenocortical","axis","in","adult","rats","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17983","tokens":["A","major","transcription","initiation","site","was","located","in","three","human","tissues","approximately","560","bp","upstream","from","the","translation","initiation","codon","and","380","bp","upstream","from","any","previously","identified","transcription","initiation","site","."],"ner_tags":[0,0,1,2,2,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0,1,2,2,0,0,0,0,1,2,2,0]}
{"id":"984","tokens":["The","transcripts","were","detected","in","all","the","CD4-","CD8-",",","CD4+","CD8+",",","CD4+","CD8-",",","and","CD4-","CD8+","cell","populations","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,8,8,8,8,8,8,8,8,8,8,8,0]}
{"id":"12989","tokens":["The","altered","cytokine","profile","observed","in","smokers","may","relate","to","an","HSF","\/","Hsp70","-mediated","inhibition","of","NFkappaB","activity","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,9,0,9,0,0,0,9,0,0]}
{"id":"5554","tokens":["It","is","generally","accepted","that","Bcl-2","exerts","its","antiapoptotic","effects","mainly","by","dimerizing","with","proapoptotic","members","of","the","Bcl-2","family","such","as","Bax","and","Bad","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,0,9,0]}
{"id":"8437","tokens":["Daidzein","and","genistein","glucuronides","in","vitro","are","weakly","estrogenic","and","activate","human","natural","killer","cells","at","nutritionally","relevant","concentrations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0]}
{"id":"13662","tokens":["In","this","communication",",","we","present","evidence","to","show","that","these","proteins","inhibit","tumor","cell","proliferation","by","participating","in","the","activation","of","tumor","cell","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12984","tokens":["We","determined","whether","Hsp70","induction","by","TS","was","mediated","by","the","activation","of","the","HS","transcription","factor",",","HSF","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0]}
{"id":"2393","tokens":["Lymphocytes","of","patients","with","rheumatoid","arthritis","(","RA",")","have","diminished","receptor","density",";","thus",",","patients","with","RA","should","show","partial","resistance","to","glucocorticoids","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16442","tokens":["Also",",","in","a","promonocyte","cell","line","chronically","infected","with","HIV",",","NF-kappa","B","expression","and","HIV","transcription","were","enhanced","on","stimulation","with","phorbol","ester","or","TNF","alpha","."],"ner_tags":[0,0,0,0,5,6,6,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"3668","tokens":["This","loss","of","activity","was","shown","to","correlate","with","deletion","of","two","CCAAT","boxes",",","a","proximal","CCAAT","box","located","at","bp","-61","to","-65","and","a","distal","CCAAT","box","located","at","bp","-253","to","-257",",","upstream","of","Cp","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,1,2,2,0,0,1,2,2,2,0,0,0,1,2,0,0,0,1,2,2,0,0,0,1,0]}
{"id":"17713","tokens":["Stimulation","of","NK","cells","with","CD16","ligands","induces","NFAT","-like","DNA","binding","activity","in","the","nuclear","extracts","from","these","cells",",","as","detected","in","electrophoretic","mobility","shift","assays","."],"ner_tags":[0,0,7,8,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14028","tokens":["Peripheral","blood","T","cells","and","monocytes","and","B","cell","lines","derived","from","patients","with","lupus","express","estrogen","receptor","transcripts","similar","to","those","of","normal","cells","."],"ner_tags":[7,8,8,8,0,7,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"6120","tokens":["In","our","previous","study",",","we","demonstrated","a","major","positive","regulatory","role","for","GATA-1","and","a","negative","regulatory","role","for","GATA-2","in","MBP","gene","transcription","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0]}
{"id":"14669","tokens":["However",",","TNF","signaling","is","largely","abolished",",","as","judged","by","the","failure","of","TNF","to","induce","NF-kappa","B","in","T","lymphocytes","from","TNFRp55","-deficient","mice","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,0,7,8,0,9,0,0,0]}
{"id":"4834","tokens":["However",",","the","inducible","degradation","of","p105","is","not","coupled","with","the","generation","of","p50","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"5600","tokens":["In","addition","to","its","role","as","a","precursor","for","other","steroid","hormones",",","DHEA","has","been","proposed","to","play","an","important","role","in","immunity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11375","tokens":["Additionally",",","we","detected","signal","transducers","and","activators","of","transcription","6","(","STAT6",")","tyrosine","phosphorylation","and","DNA","binding","activity","in","X-SCID","B","cells","with","a","wide","range","of","gammac","mutations","."],"ner_tags":[0,0,0,0,9,10,10,10,10,10,10,0,9,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,9,0,0]}
{"id":"9203","tokens":["Finally",",","we","were","able","to","generate","a","specific","CD8+","CTL","line","against","a","K-RAS","mutated","peptide","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0]}
{"id":"12895","tokens":["NF-AT","does","not","directly","bind","to","this","element","."],"ner_tags":[9,0,0,0,0,0,0,0,0]}
{"id":"5775","tokens":["Consecutive","IL-1beta-",",","IL-6-","and","TNF-alpha-mRNA","were","elevated","(","up","to","1.9","+\/-","0.58-fold",")","."],"ner_tags":[0,3,4,4,4,4,0,0,0,0,0,0,0,0,0,0]}
{"id":"3348","tokens":["The","induction","of","tyrosine","phosphorylation","of","p80c-rel","was","unique","to","G-CSF","in","that","granulocyte-macrophage","colony","stimulating","factor","which","also","stimulates","neutrophils","and","induces","tyrosine","phosphorylation","does","not","result","in","tyrosine","phosphorylation","of","p80c-rel","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,9,0,0,9,10,10,10,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"14858","tokens":["The","lymphotoxin","promoter","is","stimulated","by","HTLV-I","tax","activation","of","NF-kappa","B","in","human","T-cell","lines","."],"ner_tags":[0,1,2,0,0,0,9,10,0,0,9,10,0,5,6,6,0]}
{"id":"4952","tokens":["NF-kappaB","regulatory","effect","of","alpha-lipoate","and","N-acetylcysteine","appeared","to","be",",","at","least","in","part",",","due","to","their","ability","to","stabilize","elevation","of","[","Ca2+","]","i","following","oxidant","challenge","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2744","tokens":["Abnormalities","for","one","or","both","probes","were","detected","in","83\/95","samples","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"186","tokens":["Activation","of","NF-kappa","B","correlates","with","phosphorylation","of","I","kappa","B-alpha","and","requires","the","proteolysis","of","this","inhibitor","."],"ner_tags":[0,0,9,10,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0]}
{"id":"3890","tokens":["Latent","membrane","protein","(","LMP",")","2A","mRNA","was","detected","in","three","of","seven","cases",";","however",",","neither","LMP1","nor","LMP2B","mRNA","was","detected","in","any","of","the","tumours","tested","."],"ner_tags":[3,4,4,4,4,4,4,4,0,0,0,0,0,0,0,0,0,0,3,4,4,4,4,0,0,0,0,0,0,0,0,0]}
{"id":"2974","tokens":["The","activity","of","DNA","binding","NF-kappa","B","dimers","is","tightly","controlled","by","accessory","proteins","called","I","kappa","B","subunits","of","which","there","are","also","five","different","species","currently","known","in","vertebrates","."],"ner_tags":[0,0,0,9,10,10,10,10,0,0,0,0,9,10,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12405","tokens":["IL-10","attenuated","LPS-stimulated","TNF-alpha","production","(","297+\/-54",";","p","<",".001","versus","LPS","alone",")","."],"ner_tags":[9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16685","tokens":["First",",","deletion","analysis","revealed","that","a","region","of","TCF-1","containing","the","HMG","box","was","sufficient","for","sequence-specific","binding","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,1,2,0,0,0,0,0,0]}
{"id":"6566","tokens":["Potent","and","stable","attenuation","of","live-HIV-1","by","gain","of","a","proteolysis-resistant","inhibitor","of","NF-kappaB","(","IkappaB-alphaS32\/36A",")","and","the","implications","for","vaccine","development","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,0,0,0,0,0,0,0,0]}
{"id":"8316","tokens":["Involvement","of","adenylate","cyclase","and","p70","(","S6",")","-kinase","activation","in","IL-10","up-regulation","in","human","monocytes","by","gp41","envelope","protein","of","human","immunodeficiency","virus","type","1","."],"ner_tags":[0,0,9,10,0,9,10,10,10,10,0,0,9,0,0,7,8,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"6131","tokens":["Role","of","the","camp","response","element","site","in","mediating","repression","by","the","upstream","regulatory","region","."],"ner_tags":[0,0,0,1,2,2,2,0,0,0,0,0,1,2,2,0]}
{"id":"15225","tokens":["In","this","report",",","we","demonstrate","that","a","novel","Ets-related","transcription","factor",",","Elf-1",",","binds","specifically","to","two","purine-rich","motifs","in","the","HIV-2","enhancer","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,1,2,2,0,0,1,2,0]}
{"id":"4658","tokens":["In","this","study","we","have","analysed","the","structural","requirements","for","transcriptional","activation","by","BSAP","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"1098","tokens":["Inhibition","of","human","immunodeficiency","virus","type","1","replication","by","a","Tat-activated",",","transduced","interferon","gene",":","targeted","expression","to","human","immunodeficiency","virus","type","1-infected","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,7,8,8,8,8,8,0]}
{"id":"2160","tokens":["However",",","a","TH-dependent","positive","effect","is","elicited","by","selective","interaction","of","the","THR","beta-PPAR","but","not","the","THR","alpha-PPAR","heterodimer","with","a","novel","TRE","(","DR+2",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,0,0,0,1,0,1,0,0]}
{"id":"7301","tokens":["p70","(","s6k",")","integrates","phosphatidylinositol","3-kinase","and","rapamycin-regulated","signals","for","E2F","regulation","in","T","lymphocytes","."],"ner_tags":[9,10,10,10,0,9,10,0,0,0,0,9,0,0,7,8,0]}
{"id":"14784","tokens":["By","Northern","analysis",",","UT-7","cells","expressed","detectable","levels","of","beta-","and","gamma-globin","but","not","alpha-globin","."],"ner_tags":[0,0,0,0,5,6,0,0,0,0,9,10,10,0,0,9,0]}
{"id":"9038","tokens":["Tumor","cells","in","9","GCT","expressed","inhibin","A","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"6167","tokens":["These","bacterially-produced","MR","constructs","had","no","steroid","binding","activity","per","se","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0]}
{"id":"11635","tokens":["The","expression","of","major","histocompatibility","complex","(","MHC",")","class","II","antigens","is","constitutive","in","professional","antigen","presenting","cells","(","APCs",")","but","can","also","be","induced","by","interferon-gamma","(","IFN-gamma",")","on","the","majority","of","the","non","professional","APCs","(","e.g",".","fibroblasts",")","."],"ner_tags":[0,0,0,9,10,10,10,10,10,10,10,10,0,0,0,7,8,8,8,0,7,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,7,8,0,0,0,7,0,0]}
{"id":"13920","tokens":["Targeted","disruption","of","the","MyD88","gene","results","in","loss","of","IL-1-","and","IL-18-mediated","function","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0]}
{"id":"10270","tokens":["However",",","the","cellular","or","molecular","factors","responsible","for","a","delay","in","B-CLL","cell","death","are","unknown","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7982","tokens":["This","ANG","II","effect","was","blocked","by","the","angiotensin","AT1","receptor","antagonist","losartan","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4219","tokens":["Activation","of","the","JAK","\/STAT","pathway","has","been","implicated","in","IL-7R","signaling","."],"ner_tags":[0,0,0,9,9,0,0,0,0,0,9,0,0]}
{"id":"4147","tokens":["We","have","defined","the","mechanisms","of","transactivation","by","NFAT1","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0]}
{"id":"670","tokens":["These","activation","domains","restored","ZEBRA","'s","ability","to","induce","early","antigen","and","to","stimulate","origin","replication","to","levels","that","were","equal","to","or","greater","than","those","of","wild","type","."],"ner_tags":[0,0,0,0,9,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2122","tokens":["The","inhibition","correlated","with","a","decrease","in","steady","state","levels","of","E-selectin","mRNA","and","cell","surface","expression","of","E-selectin","which","is","consistent","with","the","ability","of","a","monoclonal","antibody","to","E-selectin","to","inhibit","monocytic","cell","adhesion","in","this","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"3834","tokens":["The","multiple","alterations","observed","on","the","various","biochemical","pathways","may","appear","as","a","consequence","of","a","unique","deleterious","mechanism","more","fundamentally","related","to","the","process","of","senescence","such","as","the","inability","to","cope","with","oxidative","stress","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5752","tokens":["We","conclude","that","CD28","costimulation","can","cause","substantial","T","cell","proliferation","in","the","absence","of","IL-2",",","which","is","driven","by","a","soluble","factor","independent","of","NF-AT","transactivation","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,0,0,9,0,0]}
{"id":"17940","tokens":["The","Janus","family","tyrosine","kinase","Jak3","is","the","only","signaling","molecule","known","to","be","associated","with","gamma","c",",","so","it","was","hypothesized","that","defects","in","Jak3","might","cause","an","XSCID-like","phenotype","."],"ner_tags":[0,9,10,10,10,9,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"9588","tokens":["Extracts","prepared","from","XP-B","and","XP-D","lymphoblastoid","cells","exhibited","similar","transcription","activity","from","the","adenovirus","major","late","promoter","when","compared","to","that","in","extracts","from","normal","cells","."],"ner_tags":[0,0,0,5,6,6,6,6,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"4236","tokens":["The","cytotoxic","properties","of","monocytes","were","not","influenced","by","the","oligos","."],"ner_tags":[0,0,0,0,7,0,0,0,0,0,0,0]}
{"id":"16664","tokens":["CONCLUSIONS","Hypercortisolaemia","does","not","down-regulate","the","lymphocyte","glucocorticoid","receptors","in","anorexia","nervosa","and","a","post-receptor","defect","might","be","involved","in","peripheral","tissue","resistance","to","the","effects","of","glucocorticoid","hormones","in","undernutrition","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8698","tokens":["Using","a","recently","developed","transfection","technique",",","we","demonstrate","that","in","primary","human","lymphocytes",",","stimulation","of","a","548","bp","IL-2","promoter-luciferase","reporter","construct","by","phorbol","ester","and","calcium","ionophore","is","reversed","by","dexamethasone","to","a","similar","extent","as","in","Jurkat","T","lymphoma","cells","transfected","with","a","GRalpha","expression","vector","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"6170","tokens":["The","Kd","value","for","aldosterone","was","0.3","nM","and","the","Bmax","=","32","pmol\/mg","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12508","tokens":["The","base","exchange","at","-509","(","from","the","transcription","initiation","site",")","in","the","TGF-beta","promoter","also","linked","to","elevated","total","IgE","(","p","<","0.01",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"13868","tokens":["Tyrosine","phosphorylation","STAT1","or","STAT3","was","not","detected","in","human","erythroid","precursors","after","stimulation","with","erythropoietin","."],"ner_tags":[0,0,9,0,9,0,0,0,0,7,8,8,0,0,0,9,0]}
{"id":"1727","tokens":["Analyses","of","hybrid","cells","show","that","TIMP",",","ZXDA",",","and","ZXDB","loci","on","the","proximal","short","arm",",","and","AR","and","PHKA1","loci","on","the","long","arm",",","are","well","expressed","from","the","tiny","ring","X","chromosome","lacking","XIST","DNA","."],"ner_tags":[0,0,5,6,0,0,1,0,1,0,0,1,2,0,0,1,2,2,0,0,1,0,1,2,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,1,2,0]}
{"id":"15610","tokens":["NF-kappa","B","binding","activity","was","inducible","by","tumor","necrosis","factor","and","phorbol","myristate","acetate","in","PLB-985","."],"ner_tags":[9,10,0,0,0,0,0,9,10,10,0,0,0,0,0,5,0]}
{"id":"11004","tokens":["The","LPS","response","was","also","more","rapid",",","as","it","was","already","evident","by","40","min","and","remained","sustained","for","up","to","3","h","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1439","tokens":["We","demonstrate","in","vitro","cleavage","of","p65","by","purified","elastase","and","cathepsin","G","."],"ner_tags":[0,0,0,0,0,0,9,0,0,9,0,9,10,0]}
{"id":"15462","tokens":["They","determine","the","outcome","of","an","antigenic","response","toward","humoral","or","cell-mediated","immunity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4816","tokens":["We","also","observed","that","cytoplasmic","p62c-fos","and","p39c-jun","were","present","in","HL60","cells","and","PHA-stimulated","PBL","."],"ner_tags":[0,0,0,0,9,10,10,10,0,0,0,5,6,0,5,6,0]}
{"id":"3048","tokens":["The","GM-CSF","gene","is","not","expressed","in","resting","peripheral","blood","T","cells","but","is","rapidly","induced","at","the","transcriptional","level","following","activation","through","the","cell","surface","T-cell","receptor","."],"ner_tags":[0,1,2,0,0,0,0,7,8,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"367","tokens":["This","action","of","the","phosphatase","inhibitors",",","which","is","associated","with","the","activation","of","the","RelA.p50","NF-kappa","B","heterodimer",",","is","not","affected","by","agents","that","block","the","induction","of","I","kappa","B","alpha","phosphorylation","by","tumor","necrosis","factor","alpha","(","TNF-alpha",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,9,10,10,10,0,9,0,0]}
{"id":"346","tokens":["Considering","the","strong","positive","regulatory","effect","of","this","element","and","its","presence","in","several","T-cell-expressed","cytokine","genes",",","it","may","be","crucial","to","the","coordinated","expression","of","these","cytokines","in","T","helper","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,9,0,7,8,8,0]}
{"id":"15591","tokens":["B","lymphocytes","and","macrophages","express","closely","related","immunoglobulin","G","(","IgG",")","Fc","receptors","(","Fc","gamma","RII",")","that","differ","only","in","the","structures","of","their","cytoplasmic","domains","."],"ner_tags":[7,8,0,0,0,0,0,9,10,10,10,10,10,10,0,9,10,10,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"14168","tokens":["[","The","trend","of","molecular","biology","study","on","eosinophils","]"],"ner_tags":[0,0,0,0,0,0,0,0,7,0]}
{"id":"4179","tokens":["This","study","demonstrates","that","GC","act","as","a","primary","inducer","of","sialoadhesin","expression","on","rat","macrophages",",","and","that","the","response","can","be","enhanced","by","IFN-beta",",","T","cell-derived","cytokines",",","or","LPS","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,0,0,0,0,0,0,0,0,0,9,0,9,10,10,0,0,0,0]}
{"id":"10376","tokens":["Our","results","suggest","that","constitutive","ETS1",",","and","inducible","NFkappaB","and","AP1",",","cooperate","as","part","of","a","higher","order","transcriptional","complex","in","activated","T","cells","."],"ner_tags":[0,0,0,0,0,9,0,0,0,9,0,9,0,0,0,0,0,0,0,0,9,10,0,0,7,8,0]}
{"id":"419","tokens":["The","granulocyte-macrophage","colony-stimulating","factor","requires","sequences","in","the","promoter","as","well","as","a","powerful","enhancer","located","3kb","upstream","to","respond","to","TCR","-like","signals","."],"ner_tags":[0,9,10,10,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,9,0,0,0]}
{"id":"4514","tokens":["Granulocyte\/macrophage","colony-stimulating","factor","and","kit","ligand","cotreatment","did","not","overcome","this","inhibition","."],"ner_tags":[9,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"15755","tokens":["These","results","are","in","striking","contrast","to","the","increase","in","nuclear","NF","kappa","B","and","HIV-1","replication","induced","by","phorbol","esters","in","promonocytic","leukemia","cells","U937","and","HL-60",",","and","emphasize","the","importance","of","studying","cytokine","regulation","of","HIV-1","in","normal","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,5,6,6,6,0,5,0,0,0,0,0,0,0,9,0,0,0,0,7,8,0]}
{"id":"1767","tokens":["Antiandrogens","result","in","protection","of","both","the","hinge","region","and","C-terminus","of","the","androgen","receptor","agonist","proteolytic","attack",",","whereas","other","studies","showed","that","antiestrogens","and","antiprogestagens","expose","the","C-terminal","end","of","the","ligand","binding","domain","of","their","respective","receptors","to","protease","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,10,0,0,0,0,0,9,0]}
{"id":"16111","tokens":["Thus",",","the","substitution","of","the","underlined","A","residue","to","a","C","within","the","GGGATTTCACC","motif","abolishes","its","T","cell-restricted","activity","and","leads","to","its","functioning","in","both","El4","cells","and","HeLa","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,5,6,0]}
{"id":"13785","tokens":["Full","activity","can","be","restored","by","the","combined","action","of","recombinant","PC4","and","the","PC4","-depleted","USA","fraction",",","thus","suggesting","a","joint","requirement","for","PC4","and","another",",","USA-derived","component","(","s",")","for","optimal","function","of","Oct-1","\/OCA-B","in","the","reconstituted","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,9,0,0,0,0,0]}
{"id":"11152","tokens":["Our","results","lend","further","support","to","the","hypothesis","that","inflammatory","and","immune","responses","of","monocytes\/macrophages","may","be","modulated","at","the","molecular","level","by","signals","originating","from","tissue","structural","cells","such","as","fibroblasts","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,7,0]}
{"id":"431","tokens":["1.","Administration","of","danazol","for","over","one","month","reduced","the","levels","of","estrogen","receptor","(","ER",")","and","its","mRNA","to","approximately","50","and","20","%",",","respectively","in","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,3,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"2362","tokens":["FK506","suppressed","the","transcriptions","through","the","AP-1","or","kappa","B-like","sites","induced","by","PMA","plus","Ca","(","2+",")","-mobilizing","agents",",","but","not","those","induced","by","Ca","(","2+",")","-independent","stimuli","."],"ner_tags":[0,0,0,0,0,0,1,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11590","tokens":["The","two","most","active","NFAT-like","elements","were","located","at","the","center","of","the","DNase","I-hypersensitive","site","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"9157","tokens":["Indomethacin","blocked","PGE2","release",",","but","had","no","influence","on","the","observed","effects","of","C3a",",","suggesting","that","the","effects","of","C3a","on","IL-6","production","are","independent","of","PGE2","formation","by","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,7,0]}
{"id":"16667","tokens":["Okadaic","acid","was","found","to","be","a","potent","inducer","of","AP1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"7637","tokens":["PHA","stimulates","IL-2R","alpha-",",","beta-",",","and","gamma-chain","expression","and","their","signaling","pathway","molecules","Jak1",",","Jak3",",","Stat1",",","Stat3",",","and","Stat5","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,9,10,10,9,0,9,0,0,0,9,0,0,9,0]}
{"id":"13492","tokens":["This","implies","that","high","levels","of","IgE","in","these","patients","either","results","from","B","cells","that","have","already","undergone","class","switching",",","from","Ig","class","switching","that","is","localized","to","target","tissues",",","or","both","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8531","tokens":["Binding","of","c-Rel","to","STAT5","target","sequences","in","HTLV-I-transformed","T","cells","."],"ner_tags":[0,0,9,0,1,2,2,0,7,8,8,0]}
{"id":"17052","tokens":["We","studied","the","effects","of","TPA","on","the","regulation","of","c-jun","gene","expression","in","HL-60","cells","during","monocytic","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,0,0,5,6,0,0,0,0]}
{"id":"3747","tokens":["Because","dephosphorylated","(","activated",")","pRB","blocks","transition","from","G1","to","S","phase","of","the","cell","cycle","whereas","phosphorylated","(","inactivated",")","pRB","releases","this","growth","arrest",",","we","characterized","the","role","of","pRB","in","IL-6","-mediated","MM","cell","growth","."],"ner_tags":[0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"14100","tokens":["Single","strand","conformation","polymorphism","analysis","of","androgen","receptor","gene","mutations","in","patients","with","androgen","insensitivity","syndromes",":","application","for","diagnosis",",","genetic","counseling",",","and","therapy","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17439","tokens":["This","is","the","first","report","of","an","EF1","-like","activity","in","non-erythroid","cells","and","indicates","that","this","factor","may","play","a","role","in","the","regulation","of","genes","expressed","in","such","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0]}
{"id":"4700","tokens":["Based","on","the","presence","of","T","cell","receptor-beta","(","TcR-beta",")","gene","rearrangements","in","L428","and","HDLM-1","cells",",","the","expression","of","CD2","in","HDLM-1","cells",",","and","the","presence","of","immunoglobulin","heavy-chain","(","IgH",")","gene","rearrangement","in","KM-H2","cells",",","some","researchers","have","concluded","that","these","long-term","cell","lines","derived","from","patients","with","Hodgkin","'s","disease","are","lymphoid","in","nature","."],"ner_tags":[0,0,0,0,0,1,2,2,2,2,2,2,2,0,5,6,6,6,0,0,0,0,9,0,5,6,0,0,0,0,0,1,2,2,2,2,2,2,0,5,6,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16801","tokens":["Induction","of","NF-KB","during","monocyte","differentiation","by","HIV","type","1","infection","."],"ner_tags":[0,0,9,0,7,0,0,0,0,0,0,0]}
{"id":"4755","tokens":["Modulation","of","endogenous","IL-1","beta","and","IL-1","receptor","antagonist","results","in","opposing","effects","on","HIV","expression","in","chronically","infected","monocytic","cells","."],"ner_tags":[0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"884","tokens":["This","study","demonstrates","that","human","immunodeficiency","virus","type","1","(","HIV-1",")","Tat","protein","amplifies","the","activity","of","tumor","necrosis","factor","(","TNF",")",",","a","cytokine","that","stimulates","HIV-1","replication","through","activation","of","NF-kappa","B","."],"ner_tags":[0,0,0,0,9,10,10,10,10,10,10,10,10,10,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"11584","tokens":["These","results","suggest","that","the","molecular","mechanism","of","HIV","inhibition","by","ascorbate","is","not","mediated","via","NF-kappa","B","inhibition",",","unlike","that","seen","with","other","antioxidants","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"14992","tokens":["Furthermore",",","we","evaluated","the","mineralocorticoid","receptor","(","MR",")","count","in","mononuclear","leukocytes","in","the","2","groups","."],"ner_tags":[0,0,0,0,0,9,10,0,9,0,0,0,7,8,0,0,0,0,0]}
{"id":"11495","tokens":["The","regulation","of","human","IL-1beta","gene","expression","has","been","studied","for","several","years",",","and","a","few","regulatory","elements","have","been","discovered","in","the","promoter","region","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,1,2,0]}
{"id":"2797","tokens":["The","three","compartments","are","thought","to","be","of","common","endodermal","origin",";","in","contrast","to","earlier","hypotheses",",","which","suggested","that","the","endocrine","compartment","was","of","neuroectodermal","origin","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"637","tokens":["Activated","T","cells","were","demonstrated","to","be","important","in","providing","the","modulating","activity","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6409","tokens":["We","conclude","that","glucocorticoids","differentially","modulate","TNFalpha","and","IL-10","secretion","by","human","monocytes","in","a","LPS","dose-dependent","fashion","and","that","the","sensitivity","of","these","cells","to","glucocorticoids","is","altered","by","TNFalpha","or","IL-10","pretreatment",";","TNFalpha","blocks","their","effects",",","whereas","IL-10","acts","synergistically","with","glucocorticoids","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"10312","tokens":["From","analyses","of","mice","deficient","in","transcription","factor","genes","and","from","the","characterizations","of","chromosome","breakpoints","in","human","leukemias",",","it","has","become","evident","that","transcription","factors","are","important","regulators","of","hematopoiesis","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"7373","tokens":["These","factors","are","present","in","nuclear","extracts","prepared","from","both","induced","and","uninduced","THP-1","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"9045","tokens":["The","Notch","receptor","protein","was","originally","identified","in","Drosophila","and","is","known","to","mediate","cell","to","cell","communication","and","influence","cell","fate","decisions","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1973","tokens":["Fos","kinase","was","rapidly","activated","after","ligation","of","the","CD3","and","CD2","receptors","in","Jurkat","and","normal","human","T","lymphocytes","and","in","response","to","IL-6","and","anti-IgM","in","the","human","B","cell","lines","AF10","and","Ramos",",","respectively","."],"ner_tags":[9,10,0,0,0,0,0,0,0,9,10,10,10,0,5,0,7,8,8,8,0,0,0,0,9,0,9,0,0,5,6,6,6,5,0,5,0,0,0]}
{"id":"8442","tokens":["DG","and","GG","were","further","purified","by","a","Sephadex","LH-20","column","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3104","tokens":["Surprisingly",",","TRAF1",",","-2",",","or","-3","does","not","interact","with","the","terminal","LMP1","CT","aa","333","to","386","which","can","independently","mediate","NF-kappaB","activation","."],"ner_tags":[0,0,9,10,10,10,10,10,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"3503","tokens":["Patients","with","steroid-resistant","asthma","have","been","shown","to","have","a","reduced","GCR","binding","affinity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"13690","tokens":["Nuclear","receptors","are","important","regulators","of","erythroid","cell","development","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0]}
{"id":"18282","tokens":["Inhibition","of","NF-AT","-dependent","transcription","by","NF-kappa","B",":","implications","for","differential","gene","expression","in","T","helper","cell","subsets","."],"ner_tags":[0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"13443","tokens":["Stimulation","of","T","cells","with","BW","828","induced","an","increase","in","intracellular","Ca2+",",","but","did","not","lead","to","detectable","activation","of","the","protein","kinases","p56","(","lck",")","and","c-Raf-1","."],"ner_tags":[0,0,7,8,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,9,10,10,10,0,9,0]}
{"id":"12774","tokens":["The","5'-UTR","also","interacts","with","a","specific","nucleosome","that","is","rapidly","displaced","during","transcriptional","activation","of","the","latent","provirus","."],"ner_tags":[0,1,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1146","tokens":["Recent","data","suggest","that","the","poor","induction","of","a","T-cell","response","to","human","renal","cell","carcinoma","(","RCC",")","may","be","related","to","alterations","in","signal","transduction","pathways","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1868","tokens":["Function","of","NF-kappa","B\/Rel","binding","sites","in","the","major","histocompatibility","complex","class","II","invariant","chain","promoter","is","dependent","on","cell-specific","binding","of","different","NF-kappa","B\/Rel","subunits","."],"ner_tags":[0,0,1,2,2,2,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"10362","tokens":["Deletion","analysis","of","the","carboxyl-terminal","region","of","Stat6","and","recombination","of","this","region","with","a","heterologous","DNA","binding","domain","allowed","the","delimitation","and","characterization","of","the","transactivation","domain","of","Stat6","."],"ner_tags":[0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"15890","tokens":["U937","cells","express","both","type","I","and","type","II","IFN","receptors",",","but","only","IFN-alpha","is","capable","of","inducing","antiviral","protection","in","these","cells","."],"ner_tags":[5,6,0,0,9,10,10,10,10,10,10,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"17315","tokens":["The","percentage","of","the","OKT8+","suppressor\/cytotoxic","T","cells","increased","when","the","inflammation","expanded","from","scanty","to","moderate","(","P","less","than","0.02",")","."],"ner_tags":[0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11453","tokens":["Hence",",","the","expression","of","LAZ3\/BCL6","does","not","correlate","to","malignancy",",","but","reflects","the","origin","of","B","cells","from","the","germinal","centers","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0]}
{"id":"13783","tokens":["Molecular","dissection","of","the","B-cell-specific","transcription","coactivator","OCA-B","has","revealed","distinct","regions","important",",","respectively",",","for","recruitment","to","immunoglobulin","promoters","through","interaction","with","octamer-bound","Oct-1","and","for","subsequent","coactivator","function","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"2331","tokens":["Elements","necessary","for","the","steroid","hormone","1","alpha",",","25-dihydroxyvitamin","D3","(","1","alpha",",","25-","(","OH",")","2D3",")","to","induce","a","biological","response","include","the","presence","of","specific","intracellular","receptors","(","vitamin","D3","receptors","(","VDR",")",")","and","modulation","of","gene","expression","via","hormone-activated","receptor","binding","to","regulatory","regions","of","target","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,1,2,0]}
{"id":"8028","tokens":["We","found","frequent","hypermutation","in","follicular","lymphoma","(","25","of","59","=","42","%",")","(","germinal","center","cell","origin",")","and","mucosa-associated","lymphoid","tissue","(","MALT",")","lymphoma","(","19","of","45","=","42","%",")","(","postgerminal","center",")",",","but","only","occasionally","in","mantle","cell","lymphoma","(","1","of","21","=","4.8","%",")","(","pregerminal","center",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13970","tokens":["We","demonstrate","that",",","in","primary","NK","cells",",","IL-13",",","but","not","IL-4",",","may","induce","low","levels","of","IFN-gamma","secretion","."],"ner_tags":[0,0,0,0,0,7,8,8,0,9,0,0,0,9,0,0,0,0,0,0,9,0,0]}
{"id":"7770","tokens":["Thus",",","the","gamma","3","ECS","is","an","inducible","promoter","containing","cis","elements","that","critically","mediate","CD40L","and","IL-4","-triggered","transcriptional","activation","of","the","human","C","gamma","3","gene","."],"ner_tags":[0,0,0,1,2,2,0,0,0,0,0,1,2,0,0,0,9,0,9,0,0,0,0,0,1,2,2,2,2,0]}
{"id":"9473","tokens":["Tolerant","cells","still","express","the","CD14","receptor","and","they","can","still","be","activated","to","mobilize","NF-kappa","B","into","nucleus","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0,0,0]}
{"id":"16827","tokens":["Three","aspects","of","the","involvement","of","tumor","necrosis","factor","in","human","immunodeficiency","virus","(","HIV",")","pathogenesis","were","examined","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11884","tokens":["An","increase","in","the","intracellular","Ca2+","concentration","is","both","necessary","and","sufficient","for","Rap1","activation","since","it","was","induced","by","agents","that","increase","intracellular","Ca2+","and","inhibited","by","a","Ca2+-chelating","agent","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13023","tokens":["The","involvement","of","NF-kappaB","in","the","PGE2-dependent","activating","effect","on","HIV-1","transcription","was","further","confirmed","using","a","kappaB-regulated","luciferase","encoding","vector","and","by","electrophoretic","mobility","shift","assays","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0]}
{"id":"5350","tokens":["X","inactivation","analysis","in","a","female","with","hypomelanosis","of","Ito","associated","with","a","balanced","X",";","17","translocation",":","evidence","for","functional","disomy","of","Xp","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,0,0]}
{"id":"2704","tokens":["Mutation","of","these","elements","indicated","that","two",",","MS-2beta","and","MS-2gamma",",","are","critical","to","the","induction","of","the","CD11b","gene","during","differentiation","of","the","pro-monocytic","cell","line","U937","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,1,2,0,0,0,0,5,6,6,6,0]}
{"id":"7721","tokens":["Furthermore",",","pre-B","cell","and","plasma","cell","lines","were","Spi-C","-negative",",","suggesting","that","Spi-C","might","be","a","regulatory","molecule","during","a","specific","phase","of","B","lymphoid","development","."],"ner_tags":[0,0,5,6,6,6,6,6,0,9,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"8221","tokens":["The","IL-2","growth","hormone","is","the","major","growth","factor","of","activated","T","lymphocytes","during","a","developing","immune","response","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"2205","tokens":["Northern","blot","analysis","of","poly","(","A",")","RNA","purified","from","the","human","B","cell","line","RPMI","8226","and","from","activated","T","cells","revealed","a","major","mRNA","transcript","of","2.2","kilobases","."],"ner_tags":[0,0,0,0,3,4,4,4,4,0,0,0,5,6,6,6,6,6,0,0,7,8,8,0,0,3,4,4,0,0,0,0]}
{"id":"13703","tokens":["T","lymphocytes","from","6","of","the","14","patients","also","exhibited","an","increased","expression","of","the","dual","specificity","phosphatase",",","map","kinase","phosphatase-1","(","MKP-1",")","."],"ner_tags":[7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,10,0,9,0,0]}
{"id":"15969","tokens":["Increased","levels","of","GR","mRNA","were","noticed","as","early","as","3","h","after","treatment","."],"ner_tags":[0,0,0,3,4,0,0,0,0,0,0,0,0,0,0]}
{"id":"12762","tokens":["The","augmentation","of","B","cell","proliferation","by","CD70","transfectants","was","apparent","in","CD27+","B","cells",",","but","was","mild","in","CD27-","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,7,8,8,0]}
{"id":"5629","tokens":["Recent","studies","have","reported","that","lymphocytes","produce",",","transport","and","bind","dopamine","present","in","plasma","."],"ner_tags":[0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"2003","tokens":["Site-directed","mutagenesis","of","one","or","more","of","these","motifs","within","the","IL-6","promoter","demonstrated","that","each","has","positive","regulatory","activity","and","that","they","could","act","in","a","function-","and","orientation-independent","manner","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9823","tokens":["Induction","of","endothelial","cell","surface","adhesion","molecules","by","tumor","necrosis","factor","is","blocked","by","protein","tyrosine","phosphatase","inhibitors",":","role","of","the","nuclear","transcription","factor","NF-kappa","B","."],"ner_tags":[0,0,9,10,10,10,10,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"15492","tokens":["Proliferation","of","T","cells","was","induced","by","immobilized","anti-CD3","monoclonal","antibody","(","mAb",")","in","the","presence","or","absence","of","an","additional","costimulatory","signal","delivered","by","anti-CD28","mAb","."],"ner_tags":[0,0,7,8,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"9717","tokens":["The","molecular","mechanisms","underlying","the","IL-7","effect","involve","the","upregulation","of","the","DNA","binding","activity","of","NFAT","(","60","%",")","and","AP-1","(","120","%",")",",","without","affecting","the","activities","of","NFkappaB","and","CD28RC",",","which","was","confirmed","by","transfection","assays","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0]}
{"id":"18429","tokens":["We","delineated","an","element","conferring","both","DNA","binding","by","the","receptor","in","vitro","and","1",",","25","(","OH",")","2D3-mediated","repression","in","vivo","to","a","short","40-bp","region","encompassing","an","important","positive","regulatory","element",",","NF-AT-1",",","which","is","bound","by","a","T-cell-specific","transcription","factor",",","NFATp",",","as","well","as","by","AP-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,2,0,1,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,9,0]}
{"id":"923","tokens":["In","an","open-label","study",",","adolescents","(","n","=","20",")","meeting","DSM-III-R","criteria","for","MDD","showed","baseline","lymphocyte","GCII","sites","per","cell","(","sites\/cell",")","values","of","793","+\/-","106","versus","2",",","563","+\/-","499","(","+\/-","SEM",")","for","matched","controls","(","n","=","18",")","(","t","=","3.5",";","df","=","36",";","p","<",".001",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1357","tokens":["Therefore",",","this","point","mutation","in","the","gamma","c","gene","leads","to","a","less","severe","degree","of","deficiency","in","cellular","and","humoral","immunity","than","that","seen","in","XSCID","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10802","tokens":["In","contrast",",","the","characterization","of","transcription","factors","selectively","regulating","cytokine","production","by","CD4+","T","cell","subsets","is","at","a","very","early","stage","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0]}
{"id":"11461","tokens":["Reconstitution","of","Jak1","expression","in","E1C3","cells","restored","the","ability","of","IL-4","to","induce","IRS","and","Stat6","tyrosine","phosphorylation","."],"ner_tags":[0,0,9,0,0,5,6,0,0,0,0,9,0,0,1,0,9,0,0,0]}
{"id":"11731","tokens":["The","results","indicate","that","stimulation","of","NK","cells",",","either","freshly","isolated","from","peripheral","blood","lymphocytes","(","PBL",")","or","long-term","cultured","NK","clones",",","with","specific","cell","targets","results","in","an","increased","binding","activity","of","NF-kappa","B","and","AP-1","transcription","factors","measured","by","gel","retardation","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,7,8,8,0,7,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,9,10,0,0,0,0,0]}
{"id":"12664","tokens":["Recently",",","a","technique","of","clonal","analysis","has","been","devised","that","takes","advantage","of","a","highly","polymorphic","short","tandem","repeat","within","the","X-linked","human","androgen","receptor","(","AR",")","gene",",","resulting","in","a","heterozygosity","rate","approaching","90","%","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"1940","tokens":["The","transcription","factor","nuclear","factor-kappa","B","(","NF-kappa","B",")","is","critical","for","the","inducible","expression","of","multiple","cellular","and","viral","genes","involved","in","inflammation","and","infection","including","interleukin-1","(","IL-1",")",",","IL-6",",","and","adhesion","molecules","."],"ner_tags":[0,9,10,9,10,10,0,9,10,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,9,0,9,0,0,9,0,0,9,10,0]}
{"id":"4307","tokens":["More","importantly",",","C-JUN","AS","oligonucleotides","showed","distinct","effects","on","two","markers","of","PMA-induced","differentiation",";","the","C-JUN","AS","oligonucleotides","inhibited","cell","adhesion",",","whereas","they","did","not","affect","another","marker","of","differentiation",",","respiratory","burst","(","measured","by","nitro","blue","tetrazolium","reduction","assay",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17927","tokens":["We","have","analyzed","several","molecular","aspects","of","IBR\/F","and","shown","that","the","factor","associates","as","stable","homodimers","and","that","the","dimer","is","the","relevant","DNA-binding","species","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,9,0,0,9,10,10,0]}
{"id":"9536","tokens":["Finally",",","gel","mobility","shift","assays","demonstrated","the","nuclear","translocation","of","proteins","specifically","bound","to","these","two","NF-kappaB","motifs",",","confirming","that","VCAM-1","was","induced","on","Tax-expressing","cells","in","a","kappaB","-dependent","manner","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,9,0,0,0,5,6,0,0,9,0,0,0]}
{"id":"2657","tokens":["These","results","suggest","that","tyrosine","phosphorylation","of","I","kappa","B","alpha","during","hypoxia","is","an","important","proximal","step","which","precedes","its","dissociation","and","degradation","from","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"3520","tokens":["Constitutive","nuclear","appearance","was","also","observed","for","NF-kB2\/p52","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"1066","tokens":["[","Regulation","of","transcription","of","the","interleukin-2","gene","in","B-lymphocytes","]"],"ner_tags":[0,0,0,0,0,0,1,2,0,7,0]}
{"id":"467","tokens":["Analysis","of","AP-1","activity","using","gel","mobility","shift","assays","confirms","that","the","requirements","for","synergy","in","c-fos","mRNA","induction","are","paralleled","by","requirements","for","synergy","in","induction","of","AP-1","activity","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"1547","tokens":["gamma","B*CaM-K","and","delta","CaM-AI",",","known","to","exhibit","constitutive","Ca","(","2+",")","-independent","activity",",","were","cotransfected","(","alone","or","in","combination",")","in","Jurkat","T","cells","with","a","plasmid","containing","the","intact","IL-2","promoter","driving","the","expression","of","the","chloramphenicol","acetyltransferase","reporter","gene","."],"ner_tags":[9,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,1,2,0,0,0,0,0,1,2,2,2,0]}
{"id":"1406","tokens":["When","analyzed","by","DNase","footprinting",",","region","II","was","protected","preferentially","in","monocytic","cells","."],"ner_tags":[0,0,0,9,0,0,1,2,0,0,0,0,7,8,0]}
{"id":"621","tokens":["Specifically",",","removal","of","the","N-terminal","36","amino","acids","of","I","kappa","B","alpha","failed","to","disrupt","its","ability","to","form","latent","complexes","with","NF-kappa","B","in","the","cytoplasm","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"4248","tokens":["This","was","identified","as","the","mRNA","encoding","the","transcription","factor","egr-1",",","which","is","expressed","with","fast","kinetics","in","T","and","NK","cells","upon","IL-2",",","but","not","IL-12",",","stimulation","."],"ner_tags":[0,0,0,0,0,3,0,0,9,10,9,0,0,0,0,0,0,0,0,7,8,8,8,0,9,0,0,0,9,0,0,0]}
{"id":"16304","tokens":["The","derived","103-amino-acid","basic","protein","has","two","potential","alpha-helical","domains","separated","by","a","hydrophobic","region","with","the","potential","to","generate","turns","and","assume","a","beta-sheet","conformation","."],"ner_tags":[0,0,9,10,10,0,0,0,9,10,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11693","tokens":["PI","3-kinase","can","thus","dynamically","influence","the","outcome","of","the","immune","reactions","at","various","stages","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10491","tokens":["The","gene","has","41","small","exons","spanning","45","kb","of","genomic","DNA","and","encoding","a","5.5","kb","mRNA","."],"ner_tags":[0,0,0,1,2,2,0,1,2,0,1,2,0,0,0,3,4,4,0]}
{"id":"6345","tokens":["The","involvement","of","p23",",","hsp90",",","and","immunophilins","in","the","assembly","of","progesterone","receptor","complexes","."],"ner_tags":[0,0,0,9,0,9,0,0,9,0,0,0,0,9,10,10,0]}
{"id":"18033","tokens":["In","transient","transfection","assays",",","Bik","promotes","cell","death","in","a","manner","similar","to","the","death-promoting","members","of","the","Bcl-2","family",",","Bax","and","Bak","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,0,9,0,9,0]}
{"id":"6689","tokens":["Human","T-cell","leukemia","virus","type","1","(","HTLV-1",")","Tax","transforms","normal","T-cells","in","the","presence","of","interleukin","(","IL",")","-2","in","vitro","."],"ner_tags":[9,10,10,10,10,10,10,10,10,10,0,0,7,0,0,0,0,9,10,10,10,10,0,0,0]}
{"id":"12932","tokens":["Taken","together",",","our","results","will","help","to","understand","the","complex","interactions","occurring","between","HHV-6","and","the","CD4","promoter","and","provide","additional","information","regarding","the","class","of","transcription","factors","involved","in","the","control","of","CD4","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,1,2,0,0]}
{"id":"2020","tokens":["Wild-type","and","chimeric","HLF","proteins","also","bound","closely","related","sites","identified","previously","for","bZIP","proteins","of","both","the","proline","-and","acidic","amino","acid-rich","(","PAR",")","and","C\/EBP","subfamilies",";","however",",","E2A-HLF","proteins","were","significantly","less","tolerant","of","certain","deviations","from","the","HLF","consensus","binding","site","."],"ner_tags":[0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,0,0,0,9,0,0,0,0,0,9,0,0,9,10,0,0,0,9,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"15671","tokens":["The","protein","Bcl-3","contains","seven","so-called","ankyrin","repeats","."],"ner_tags":[0,9,10,0,0,0,9,10,0]}
{"id":"9731","tokens":["The","DNA","binding","domain","of","the","A-MYB","transcription","factor","is","responsible","for","its","B","cell-specific","activity","and","binds","to","a","B","cell","110-kDa","nuclear","protein","."],"ner_tags":[0,9,10,10,0,0,9,9,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"1415","tokens":["Treatment","of","a","human","promyelocytic","leukemia","cell","line",",","HL-60",",","with","10","micrograms\/mL","etoposide","or","2","microM","1-beta-D-arabinofuranosylcytosine","induced","NF-kappa","B","activation","within","1","hr","and","subsequently","caused","apoptosis","within","3-4","hr","."],"ner_tags":[0,0,0,5,6,6,6,6,0,5,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17066","tokens":["It","is","shown","that","the","low","level","of","steroid","receptors",",","thyroid","hormones","that","the","low","level","of","steroid","receptors",",","thyroid","hormones","(","T3","and","T4",")","and","cortisol","is","typical","of","children","with","the","signs","of","renal","dysplasia","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3356","tokens":["We","have","developed","a","monoclonal","antibody",",","Yae",",","which","is","specific","for","Pan\/E2A","proteins",",","and","have","used","the","Yae","antibody","to","examine","a","variety","of","endocrine","and","nonendocrine","cell","lineages","for","differences","in","Pan\/","E2A","protein","expression",",","subcellular","localization",",","and","heteromeric","complex","formation","."],"ner_tags":[0,0,0,0,9,10,0,9,0,0,0,0,0,9,10,0,0,0,0,0,9,10,0,0,0,0,0,7,8,8,8,8,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"11278","tokens":["Cytomegalovirus","IE","gene","products","significantly","enhanced","LPS","stimulation","of","IL-6","promoter","activity","in","both","IL-6","CAT","and","IL-6","luciferase","assays","."],"ner_tags":[9,10,10,10,0,0,0,0,0,1,2,0,0,0,9,0,0,0,0,0,0]}
{"id":"8957","tokens":["Increased","expression","of","wild-type","NFAT1","substantially","increases","IL-4","promoter","activity","in","unprimed","CD4","T","cells",",","suggesting","NFAT1","may","be","limiting","for","IL-4","gene","expression","in","this","cell","type","."],"ner_tags":[0,0,0,0,9,0,0,1,2,0,0,0,7,8,8,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"673","tokens":["Evidence","for","the","involvement","of","Janus","kinase","3","and","interleukin-4","Stat","."],"ner_tags":[0,0,0,0,0,9,10,10,0,9,10,0]}
{"id":"17021","tokens":["ZRE-B","can","be","deleted","without","affecting","the","R-dependent","enhancer","activity","."],"ner_tags":[1,0,0,0,0,0,0,0,0,0,0]}
{"id":"14023","tokens":["Fibrinogen","also","caused","activation","of","AP-1",",","but","not","SP1","or","cAMP","response","element-binding","protein","(","CREB",")","factors","."],"ner_tags":[9,0,0,0,0,9,0,0,0,9,0,9,10,10,10,10,10,10,10,0]}
{"id":"12897","tokens":["Our","data","also","show","that","the","immunosuppressive","agent","cyclosporin","A","down-regulates","CD95L","transcription","by","inhibiting","the","function","of","this","positive","regulatory","element"],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,1,2]}
{"id":"12175","tokens":["During","monocyte-to-macrophage","differentiation",",","the","cellular","content","of","vacuolar","H+-ATPase","(","V-ATPase",")","increases","more","than","4-fold","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0]}
{"id":"10391","tokens":["IFN-gamma-primed","lung","fibroblasts","costimulate","T","lymphocyte","proliferation","utilizing","CD40",",","but","not","the","well-studied","costimulatory","molecules","B7-1","and","B7-2","."],"ner_tags":[5,6,6,0,0,0,0,0,9,0,0,0,0,0,9,10,9,0,9,0]}
{"id":"13670","tokens":["Administration","of","the","cytokine","interleukin-2","(","IL-2",")","can","result","in","therapeutic","benefits","for","individuals","with","renal","cell","carcinoma","and","melanoma","."],"ner_tags":[0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7420","tokens":["Characterization","of","expression","of","the","gene","for","human","pterin","carbinolamine","dehydratase\/dimerization","cofactor","of","HNF1","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,10,0,9,0]}
{"id":"205","tokens":["DR-nm23","mRNA","is","preferentially","expressed","at","early","stages","of","myeloid","differentiation","of","highly","purified","CD34+","cells","."],"ner_tags":[3,4,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"2820","tokens":["The","NF-kappa","B","inhibitor",",","tepoxalin",",","suppresses","surface","expression","of","the","cell","adhesion","molecules","CD62E",",","CD11b\/CD18","and","CD106","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,9,10,10,9,0,9,0,9,0]}
{"id":"7421","tokens":["Pterin","carbinolamine","dehydratase\/dimerization","cofactor","of","HNF1","(","PCD\/DCoH",")","is","a","dual-function","protein","."],"ner_tags":[9,10,10,10,0,9,0,9,0,0,0,9,10,0]}
{"id":"3271","tokens":["Changes","in","triiodothyronine","(","T3",")","mononuclear","leukocyte","receptor","kinetics","after","T3","administration","and","multiple","cold-air","exposures","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11603","tokens":["Assembly","of","terminal","complement","complexes","(","TCC",")","C5b-7",",","C5b-8",",","and","C5b-9","on","target","cells","during","acute","and","chronic","inflammation","induces","hydrolysis","of","plasma","membrane","phospholipids","and","heterotrimeric","G","protein","activation","."],"ner_tags":[0,0,9,10,10,0,9,0,9,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"12136","tokens":["The","peroxisome","proliferator-activated","receptor","(","PPARalpha",")","transcription","factor","is","expressed","in","HL-60","cells",",","but","no","changes","were","observed","in","its","expression","upon","HL-60","cell","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4053","tokens":["Although","identical","in","composition","and","stoichiometry","to","TFIIHwt",",","TFIIHmut","shows","a","reduced","3","'","--",">","5","'","XPB","helicase","activity","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"16857","tokens":["Two","types","of","responses","were","compared","after","a","single","MP","dose","(","40","mg","bolus",")","and","a","divided","regimen","(","20","mg","bolus","and","a","5","mg","bolus","8","hours","later",")","in","six","healthy","male","volunteers","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3067","tokens":["These","findings","may","have","important","implications","for","the","design","of","alternative","treatment","approaches","for","recalcitrant","asthma","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11116","tokens":["c-Fos","protein","was","shown","essential","for","an","optimal","transactivation","of","the","HIV-1","long","terminal","repeat","(","LTR",")","by","Tat",":","incubation","of","Jurkat","cells","with","antisense",",","but","not","sense",",","c-fos","oligonucleotides","significantly","reduced","either","the","Tat","-enhanced","expression","of","an","LTR-CAT","reporter","construct","or","the","levels","of","gag","p24","in","the","culture","supernatants","of","Jurkat","cells","and","PBMC","acutely","infected","with","HIV-1","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,1,0,0,9,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,1,2,2,0,0,0,0,9,10,0,0,0,0,0,5,6,0,7,0,0,0,0,0]}
{"id":"6183","tokens":["Indeed",",","we","detected","gangliosides","in","supernatants","from","RCC","explants","and","not","from","adjacent","normal","kidney","tissue","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0]}
{"id":"16367","tokens":["All","the","isoforms","retain","the","previously","characterized","POU-domain","and","are","therefore","able","to","bind","to","the","octamer","motif","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"1219","tokens":["The","exact","mechanism","by","which","IL-2","regulates","transcription","of","different","genes","is","presently","unknown","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"11618","tokens":["Northern","analyses","suggested","that","the","reiterated","splicing","sites","of","the","representative","mutants","were","all","used","in","RNA","splicing",",","and","the","closest","donor","and","recipient","joints","were","used","most","frequently","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15467","tokens":["We","have","previously","found","a","cis-acting","region","spanning","the","GM-CSF","promoter","region","(","positions","-95","to","+27",")","that","confers","inducibility","to","reporter","genes","in","transient","transfection","assays","."],"ner_tags":[0,0,0,0,0,1,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0]}
{"id":"1426","tokens":["In","contrast","to","parental","U937","cells",",","PKC-zeta","cells","constitutively","expressed","mRNA","transcripts","for","c-jun","and","a","low","mobility","AP-1","binding","activity","."],"ner_tags":[0,0,0,0,5,6,0,5,6,0,0,3,4,0,1,0,0,0,0,9,0,0,0]}
{"id":"12555","tokens":["Glucocorticoids","are","physiological","molecules","that","are","also","extensively","used","in","clinics","as","anti-inflammatory",",","immunosuppressive","or","anti-tumoral","agents","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8717","tokens":["IL-4","gene","regulation","in","general","involves","the","nuclear","factor","of","activated","T","cells","(","NFAT",")","family","of","transcription","factors",",","of","which","NFAT1","and","NFAT2","are","most","prominent","in","peripheral","T","cells","."],"ner_tags":[1,2,0,0,0,0,0,9,10,10,10,10,10,10,10,10,10,0,9,10,0,0,0,9,0,9,0,0,0,0,7,8,8,0]}
{"id":"13145","tokens":["Using","semiquantitative","RT-PCR",",","we","found","a","striking","increase","in","IL-6","mRNA","levels","only","in","resuscitated","HS",",","with","peak","levels","observed","1","h","after","initiation","of","resuscitation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12000","tokens":["Supershift","with","specific","antibodies","to","NF-kappa","B","subunits","confirmed","that","the","inducible","retarded","bands","observed","in","the","EMSA","and","p65-p50","heterodimer","of","the","NF-kappa","B\/Rel","protein","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,10,0]}
{"id":"4085","tokens":["The","primary","RNA","transcript","of","the","gene","is","subject","to","alternative","splicing","to","yield","different","variants","which","can","either","activate","or","repress","gene","expression","."],"ner_tags":[0,3,4,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2433","tokens":["To","make","clear","the","roles","of","RA","and","RAR","alpha","in","the","normal","hematopoiesis",",","I","have","introduced","the","construct","of","human","RAR","alpha","(","hRAR","alpha",")","into","murine","bone","marrow","cells","with","retroviral","vector",",","and","selected","infected","cells","with","drug","resistant","marker","(","Neo","(","r",")",")","cultured","on","the","stroma","cell","line","(","PA6-neo",")",",","and","analyzed","the","behavior","of","infected","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,1,2,2,0,1,2,2,2,0,0,0,0,5,6,6,0,5,0,0,0,0,0,0,0,7,8,0]}
{"id":"2539","tokens":["Furthermore",",","the","present","results","demonstrate","clearly","that","mycoplasma","products","can","have","a","profound","impact","on","the","activation","status","of","eukaryotic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"16210","tokens":["The","current","work","describes","the","regulation","of","TNF","in","human","myelomonocytic","cell","lines","after","PMA","stimulation","."],"ner_tags":[0,0,0,0,0,0,0,9,0,5,6,6,6,0,0,0,0]}
{"id":"15011","tokens":["Interleukin-3","expression","by","activated","T","cells","involves","an","inducible",",","T-cell-specific","factor","and","an","octamer","binding","protein","."],"ner_tags":[9,0,0,7,8,8,0,0,0,0,9,10,0,0,9,10,10,0]}
{"id":"3754","tokens":["Soluble","factors","secreted","by","activated","T-lymphocytes","modulate","the","transcription","of","the","immunosuppressive","cytokine","TGF-beta","2","in","glial","cells","."],"ner_tags":[9,10,0,0,7,8,0,0,0,0,0,9,10,9,10,0,7,8,0]}
{"id":"858","tokens":["Our","data","indicate","that","increased","NF-kappa","B","DNA","binding","and","functional","activity","are","present","in","B-lymphoid","cells","stably","or","transiently","expressing","LMP-1","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,7,8,0,0,0,0,9,0]}
{"id":"7578","tokens":["Retinoic","acid","induces","apoptosis","of","human","CD34+","hematopoietic","progenitor","cells",":","involvement","of","retinoic","acid","receptors","and","retinoid","X","receptors","depends","on","lineage","commitment","of","the","hematopoietic","progenitor","cells","."],"ner_tags":[0,0,0,0,0,7,8,8,8,8,0,0,0,9,10,10,0,9,10,10,0,0,0,0,0,0,7,8,8,0]}
{"id":"12972","tokens":["S9a","was","superior","to","the","first","generation","compound","Canventol",",","which","was","superior","to","the","natural","compound","sarcophytol","A",",","demonstrating","that","further","structure-based","enhancement","of","potency","of","these","compounds","is","feasible","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12647","tokens":["The","results","of","reporter","gene","analyses","revealed","that","the","insulin","gene","promoter","is","more","sensitive","to","glycation","than","the","control","beta-actin","gene","promoter",";","approximately","50","and","80","%","of","the","insulin","gene","promoter","activity","was","lost","when","the","cells","were","kept","for","3","d","in","the","presence","of","40","and","60","mM","D-ribose",",","respectively","."],"ner_tags":[0,0,0,1,2,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8732","tokens":["The","low","binding","affinity","of","squirrel","monkey","GR","does","not","result","from","substitutions","in","the","receptor",",","because","squirrel","monkey","GR","expressed","in","vitro","exhibits","high","affinity","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"6331","tokens":["In","contrast",",","BCL-6","was","expressed","only","in","a","small","percentage","of","Hodgkin","and","Reed-Sternberg","cells","in","about","30","%","of","classical","HD","cases","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0]}
{"id":"13124","tokens":["This","study","shows","that","expression","of","LMP1","activates","transcription","from","p50\/p65-","and","c-Rel-","responsive","promoters",",","and","that","this","activity","can","be","completely","inhibited","by","expression","of","a","dominant","inhibitory","IkappaB","mutant","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,1,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"4675","tokens":["To","study","the","molecular","mechanisms","that","control","the","transcription","of","the","CD36","gene","in","monocytic","cells","we","have","isolated","and","analyzed","the","CD36","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"2910","tokens":["The","SCMV","SNE","sites","contain","potential","overlapping","core","recognition","binding","motifs","for","SRF",",","Rel\/NFkappaB",",","ETS",",","and","YY1","class","transcription","factors","but","fail","to","respond","to","either","serum","or","tumor","necrosis","factor","alpha","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,9,0,9,0,9,0,0,9,10,10,10,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"974","tokens":["The","promoter","region","between","-173","and","-60","contained","the","strongest","activating","elements","."],"ner_tags":[0,1,2,0,1,2,2,0,0,0,1,2,0]}
{"id":"18529","tokens":["Lymphoid","enhancer-binding","factor","1","(","LEF-1",")","is","a","regulatory","high","mobility","group","(","HMG",")","protein","that","activates","the","T","cell","receptor","alpha","(","TCR","alpha",")","enhancer","in","a","context-restricted","manner","in","T","cells","."],"ner_tags":[9,10,10,10,0,9,0,0,0,9,10,10,10,10,10,10,10,0,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,7,8,0]}
{"id":"16195","tokens":["This","lack","of","sensitivity","is","unexplained","but","is","not","attributable","to","abnormalities","of","cellular","glucocorticoid","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"13744","tokens":["Analysis","of","monocytes","from","familial","hypercholesterolemic","(","FH",")","subjects",",","who","frequently","develop","xanthomatosis",",","revealed","a","significant","number","of","subjects","with","elevated","STAT1alpha","and","IP-10","expression","."],"ner_tags":[0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1186","tokens":["At","least","two","distinct","domains","of","the","receptor","mediated","interaction","with","hsp90",":","the","ligand-binding","domain","located","within","the","PAS","region","and",",","surprisingly",",","the","bHLH","domain","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,0,0,0,9,10,0,0,0,0,0,9,10,0]}
{"id":"14988","tokens":["Pregnancy-induced","hypertension","(","PIH",")","is","a","frequent","cause","of","maternal","and","neonatal","morbidity","and","mortality","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6779","tokens":["SLP-76","and","Vav",",","two","hematopoietic","cell","specific","molecules",",","are","critical","for","T","cell","development","and","activation","."],"ner_tags":[9,0,9,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"2357","tokens":["CD14","Sp1","site","oligonucleotides","bound","preferentially","to","a","105-kDa","Sp1","species",",","which","is","present","in","higher","relative","levels","in","monocytic","than","non-monocytic","cells",",","suggesting","that","modification","of","Sp1",",","such","as","phosphorylation",",","may","explain","how","the","Sp1","site","mediates","monocytic","specific","promoter","activity","."],"ner_tags":[9,9,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,7,0,7,8,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"13417","tokens":["The","differences","between","wild-type","and","mutated","receptors","in","the","induction","of","apoptosis","were","not","related","to","levels","of","p56","(","lck",")","or","NF-","kappaB","activation","."],"ner_tags":[0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,10,0,0]}
{"id":"5855","tokens":["Two","such","clusters","were","found","to","have","patterns","that","correlated","with","variation","in","cell","proliferation","rates","and","with","activation","of","the","IFN","-regulated","signal","transduction","pathway",",","respectively","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"4747","tokens":["The","maximum","levels","of","these","markers","induced","by","ML-9","were","comparable","to","those","induced","by","VD3",",","but","after","removal","of","ML-9","from","the","medium","by","washing","the","cells",",","the","expressions","of","theses","markers","decreased","within","4","hours","and","reached","basal","levels","in","1","day",",","indicating","that","ML-9","'s","induction","of","expression","of","differentiation-associated","phenotypes","was","reversible","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15128","tokens":["Cell","culture","experiments","demonstrated","that","the","natural","variant","with","four","Sp1","sites","had","a","slightly","higher","promoter","activity","and","viral","replication","rate","than","the","isogenic","control","LTR","with","three","Sp1","sites","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,0]}
{"id":"9096","tokens":["To","explore","long-term","regulatory","mechanisms",",","we","investigated","the","induction","of","transcription","factors","on","the","gene","expression","level","which","may","be","important","to","substitute","for","metabolized","transcription","factor","proteins","after","their","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"8877","tokens":["Regulation","of","fas-ligand","expression","during","activation-induced","cell","death","in","T","lymphocytes","via","nuclear","factor","kappaB","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,9,10,10,0]}
{"id":"12517","tokens":["In","addition",",","they","suggested","that","the","activation","of","the","IL-2","promoter","is","under","the","control","of","not","only","NFAT","but","also","a","second","factor","whose","activation","is","MEK","-dependent","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"18086","tokens":["This","enhancer","in","HIV-1","is","the","T-cell","activation","response","element",";","in","HIV-2",",","however",",","it","is","the","second","enhancer","that","is","mainly","responsible","for","activation","in","response","to","T-cell","activators","."],"ner_tags":[0,1,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12641","tokens":["The","mechanism","of","reduced","GR","levels","in","relation","to","age","and","sport","activity","could","involve","a","loss","or","an","involution","of","receptor","synthesis","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4007","tokens":["In","this","study",",","we","examined","the","functional","role","of","cysteine","and","arginine","residues","in","the","ligand-binding","domain","of","hRAR","alpha","(","hRAR","alpha-LBD",",","amino","acids","154","to","462",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,9,10,0,9,10,10,10,10,0,0]}
{"id":"3592","tokens":["The","closest","match","to","the","known","SP-1","consensus","sequence","within","the","respective","region","is","a","TCCCCTCCCCT","motif","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,1,2,0]}
{"id":"13531","tokens":["Moreover",",","our","data","provide","evidence","that","the","expression","pattern","of","MHC","class","II","mRNA","is","correlated","with","that","of","the","class","II","transactivator","(","CIITA",")",",","suggesting","that","CIITA","is","the","actual","target","of","the","silencing","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,3,4,4,4,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"995","tokens":["This","may","be","an","important","molecular","site","of","steroid","action","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10455","tokens":["Production","of","functional","IL-12","requires","the","coordinated","expression","of","both","genes","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"17186","tokens":["Here","we","report","that","the","formation","of","two","distinct","mitogen-inducible","DNA-binding","complexes",",","the","kappa","B","complex","within","the","HIV","enhancer","and","the","NFAT-1","complex","within","the","interleukin-2","enhancer",",","is","inhibited","in","the","presence","of","CsA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,10,10,0,0,1,2,0,0,9,10,0,0,1,2,0,0,0,0,0,0,0,0,0]}
{"id":"6236","tokens":["The","promoter","and","5","'","flanking","sequences","controlling","human","B29","gene","expression","."],"ner_tags":[0,1,0,1,2,2,2,0,0,1,2,0,0]}
{"id":"16008","tokens":["Furthermore",",","activation","of","PKC","was","pertussis-toxin-sensitive","and","was","associated","with","the","detection","of","an","NF","kappa","B","protein","in","nuclear","extracts","of","M-CSF-induced","blood","monocytes","but","not","in","monocytes","exposed","to","medium","treatment","only","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,5,6,6,0,0,0,7,0,0,0,0,0,0]}
{"id":"14260","tokens":["We","have","identified","two","adjacent","cis-acting","regulatory","elements",",","both","of","which","are","part","of","an","Alu","repeat","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11179","tokens":["These","studies","were","conducted","with","highly","purified","(","FACS-isolated",")","subsets","of","CD4","T","cells","identified","by","expression","of","both","CD45RA","and","CD62L","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,9,0,9,0]}
{"id":"481","tokens":["We","found","that","expression","of","a","constitutively","active","form","of","calcineurin","could","substitute","for","Ca2+","ionophore","and","synergize","with","PMA","to","activate","the","GM-CSF","promoter",",","and","conversely","that","mutant-activated","Ras","could","substitute","for","PMA","and","cooperate","with","Ca2+","ionophore","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"13321","tokens":["Here",",","we","show","that","ectopic","expression","of","GATA-3","is","sufficient","to","drive","IL-5","but","not","IL-4","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,9,0,0,0]}
{"id":"5733","tokens":["Certain","classes","of","AIDS","NHL","are","associated","with","alterations","in","oncogenes","or","tumor-suppressor","genes","or","infections","by","oncogenic","herpesviruses","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,1,2,0,0,0,0,0,0]}
{"id":"2620","tokens":["Analysis","of","Oct2-isoform","expression","in","lipopolysaccharide-stimulated","B","lymphocytes","."],"ner_tags":[0,0,9,0,0,5,6,6,0]}
{"id":"15891","tokens":["Pretreatment","with","IFN-gamma","potentiates","the","IFN-alpha","-induced","protection",",","but","IFN-gamma","alone","does","not","have","any","antiviral","activity","."],"ner_tags":[0,0,9,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"17210","tokens":["The","tissue-specific","expression","of","the","MOPC","141","immunoglobulin","heavy-chain","gene","was","studied","by","using","in","vitro","transcription","."],"ner_tags":[0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,0,0]}
{"id":"3502","tokens":["In","addition",",","a","significant","correlation","was","noted","between","the","degree","of","inhibition","of","lymphocyte","proliferation","(","IC50",")","and","the","binding","affinity","of","dexamethasone","to","the","GCR","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"10305","tokens":["The","prolactin","receptor",",","a","member","of","the","hematopoietin\/cytokine","receptor","superfamily",",","is","ubiquitously","expressed","by","cells","in","the","immune","system","."],"ner_tags":[0,9,10,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5","tokens":["Our","data","suggest","that","lipoxygenase","metabolites","activate","ROI","formation","which","then","induce","IL-2","expression","via","NF-kappa","B","activation","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,9,0,0,9,10,0,0]}
{"id":"3835","tokens":["Induction","of","bcl-2","expression","by","phosphorylated","CREB","proteins","during","B-cell","activation","and","rescue","from","apoptosis","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17213","tokens":["Purified","OTF1","from","HeLa","cells","and","OTF1","and","OTF2","from","B","cells","bound","to","identical","sequences","within","the","heavy-chain","promoter","."],"ner_tags":[0,9,0,5,6,0,9,0,9,0,7,8,0,0,0,0,0,0,1,2,0]}
{"id":"17346","tokens":["A","somewhat","surprising","finding","however","was","a","very","strong","association","between","oncogene","amplification","and","dense","lymphocyte","infiltration","of","the","tumor","(","P","=",".05",")",".","This","correlation","is","even","stronger","when","only","high","levels","of","amplification","are","considered",",","either","for","each","oncogene","separately","(","P","=",".0048",")","or","in","combination","(","P","=",".0007",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3113","tokens":["Consequently",",","IL-12","also","failed","to","induce","the","DNA-binding","activity","of","STAT4-containing","complexes","in","the","nuclei","of","these","Th2","clones","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,5,6,0]}
{"id":"561","tokens":["These","results","demonstrate","that","the","IL-2","NF-chi","B","site","is","indispensable","for","the","activity","of","the","IL-2","promoter","in","EBV-transformed","B","cells",",","whereas","other","transcription","factors","appear","to","be","less","important","for","IL-2","expression","in","these","cells","."],"ner_tags":[0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,1,2,0,5,6,6,0,0,0,9,10,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"12784","tokens":["Although","interleukin","(","IL",")","-12","was","originally","purified","from","an","Epstein-Barr","(","EBV",")","-transformed","B","cell","line","and","the","high","correlation","of","EBV","infection","and","IL-12","expression","has","been","suggested",",","no","study","has","reported","whether","EBV","infection","is","directly","linked","to","IL-12","expression","."],"ner_tags":[0,9,10,10,10,10,0,0,0,0,0,5,6,6,6,6,6,6,6,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"7878","tokens":["This","is","the","first","demonstration","that","lithium","can","alter","gene","expression","of","Tcf-responsive","genes",",","and","points","to","a","difference","in","regulation","of","Wnt","signaling","between","fibroblasts","and","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,7,0,7,0]}
{"id":"3998","tokens":["In","all","the","subjects",",","dexamethasone","was","able","to","suppress","plasma","cortisol","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13772","tokens":["Taken","together",",","our","data","suggest","that","Stat1alpha","and","Stat3","act","as","negative","regulators","in","EPO","-induced","erythroid","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,9,0,0,0,0]}
{"id":"6749","tokens":["Association","of","the","interleukin-4","receptor","alpha","chain","with","p47phox",",","an","activator","of","the","phagocyte","NADPH","oxidase","in","B","cells","."],"ner_tags":[0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,10,10,0,7,8,0]}
{"id":"4339","tokens":["The","preferential","induction","of","c-jun","by","H2O2","did","not","represent","redox","stabilization","of","mRNA","transcripts",",","and","oxidative","signals","closely","resembled","PHA\/PMA","stimulation","by","effectively","transactivating","the","full","length","c-jun","promoter","via","the","proximal","jun1","tumor","promoter-responsive","element","(","TRE",")","-like","promoter","element","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0]}
{"id":"13302","tokens":["Ras","can","initiate","Rac-1","regulated","signaling","pathways","in","the","context","of","T","cell","antigen","receptor","function","independently","of","PtdIns","3-kinase","activity","."],"ner_tags":[9,0,0,9,0,0,0,0,0,0,0,9,10,10,10,0,0,0,9,10,0,0]}
{"id":"16067","tokens":["It","is","very","likely","that","these","domains","bind","megakaryocyte-specific","nuclear","proteins","acting","as","positive","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,9,10,10,0]}
{"id":"11131","tokens":["The","two","AP-1","sites","bound","c-Fos\/c-Jun","heterodimers","in","both","unstimulated","and","LPS-stimulated","cells","."],"ner_tags":[0,0,1,2,0,9,10,0,0,7,8,8,8,0]}
{"id":"17101","tokens":["In","order","to","investigate","this","possibility",",","we","measured","the","concentration","of","VDR","in","PHA-activated","peripheral","mononuclear","cells","from","10","XLH","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,5,6,6,6,0,0,0,0,0]}
{"id":"18149","tokens":["It","binds","the","so-called","Pu","box",",","an","important","tissue-specific","regulatory","DNA","element","present","in","a","number","of","genes","expressed","in","these","cell","lineages","."],"ner_tags":[0,0,0,0,1,2,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"855","tokens":["The","mechanisms","by","which","LMP-1","upregulates","these","proteins","is","unknown",",","but","it","is","plausible","that","LMP-1","modifies","signal","transduction","pathways","that","result","in","the","activation","of","one","or","more","transcription","factors","that","ultimately","regulate","transcription","of","oncogenic","genes","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,1,2,0]}
{"id":"9151","tokens":["Regulation","of","IL-6","synthesis","in","human","peripheral","blood","mononuclear","cells","by","C3a","and","C3a","(","desArg",")","."],"ner_tags":[0,0,9,0,0,7,8,8,8,8,0,9,0,9,10,10,10,0]}
{"id":"4723","tokens":["An","AP-1","site","at","-146","to","-140","was","shown","to","be","involved","in","the","expression","of","the","IL-9","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"16625","tokens":["The","rate","of","transcription","initiation","directed","by","the","long","terminal","repeat","(","LTR",")","of","HIV-1","increases","in","response","to","mitogenic","stimuli","of","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"14339","tokens":["Resting","T-cell","nuclear","extracts","contained","KBF1\/p50","homodimer","."],"ner_tags":[0,0,0,0,0,9,10,0]}
{"id":"7741","tokens":["Type","I","interferons","(","IFNs",")","are","a","family","of","cytokines","that","have","antiviral","and","antiproliferative","effects","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"11318","tokens":["AML1a","expression","was","associated","with","enhanced","sensitivity","to","megakaryocytic","differentiation","induced","by","phorbol","ester","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"29","tokens":["The","results","identify","functionally","distinct","epitopes","on","the","CD4","coreceptor","involved","in","activation","of","the","Ras\/protein","kinase","C","and","calcium","pathways","."],"ner_tags":[0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,9,10,10,0,0,0,0]}
{"id":"17420","tokens":["The","importance","of","the","internal","ATGs","to","Rex","function","is","not","known","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"18155","tokens":["The","findings","in","the","human","multiple","myeloma","cell","lines","represent","the","first","examples","of","B","cells","with","downregulated","PU.1","expression","and","apparently","contradict","observations","in","the","murine","system","in","which","PU.1","is","expressed","and","active","in","plasmacytoma","cell","lines","."],"ner_tags":[0,0,0,0,5,6,6,6,6,0,0,0,0,0,7,8,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,5,6,6,0]}
{"id":"14272","tokens":["Regression","analysis","of","our","data","revealed","slight","trends","for","some","of","the","biomarkers","(","e.g.","CD45R0+",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4902","tokens":["Interferon-gamma","modulates","the","lipopolysaccharide-induced","expression","of","AP-1","and","NF-kappa","B","at","the","mRNA","and","protein","level","in","human","monocytes","."],"ner_tags":[9,0,0,0,0,0,9,0,9,10,0,0,0,0,0,0,0,7,8,0]}
{"id":"14413","tokens":["As","described","by","Jun","Liu",",","these","drugs","manifest","their","effects","in","an","unprecedented","fashion","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14478","tokens":["A","chimeric","type","II\/type","I","interleukin-1","receptor","can","mediate","interleukin-1","induction","of","gene","expression","in","T","cells","."],"ner_tags":[0,9,10,10,10,10,10,0,0,9,0,0,0,0,0,7,8,0]}
{"id":"5482","tokens":["The","effects","of","the","two","cytokines","were","distinguishable","functionally","since","pretreatment","with","TNF-alpha","attenuated","the","cytokine","cooperativity",",","while","pretreatment","with","IL-10","potentiated","their","cooperativity",",","suggesting","that","IL-10","and","TNF-alpha","play","different","roles","in","the","activation","of","virus","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"7620","tokens":["Corticosteroids","are","most","effective","in","preventing","the","late","phase","of","allergic","reaction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14087","tokens":["Transient","expression","analyses","in","cells","of","neuroglial","and","lymphocytic","origin","demonstrated","that","some","of","these","LTRs","had","activities","which","varied","significantly","from","the","LAI","LTR","in","U-373","MG","cells","(","an","astrocytoma","cell","line",")","as","well","as","in","Jurkat","cells","(","a","CD4-positive","lymphocyte","cell","line",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,2,0,5,6,6,0,0,5,6,6,0,0,0,0,0,5,6,0,0,5,6,6,6,0,0]}
{"id":"8764","tokens":["We","exploited","this","ability","of","Hsp70","to","deliver","NF-kappaB",",","a","key","transcriptional","regulator","of","inflammatory","responses","."],"ner_tags":[0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"5534","tokens":["Transcription","factor","activation","and","gene","transcription","were","studied","by","gel-shift","assays","and","Northern","blot","analysis",",","respectively","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13978","tokens":["The","human","toll","signaling","pathway",":","divergence","of","nuclear","factor","kappaB","and","JNK","\/SAPK","activation","upstream","of","tumor","necrosis","factor","receptor-associated","factor","6","(","TRAF6",")","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,9,9,0,0,0,9,10,10,10,10,10,0,9,0,0]}
{"id":"1323","tokens":["Separation","of","oxidant-initiated","and","redox-regulated","steps","in","the","NF-kappa","B","signal","transduction","pathway","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"17441","tokens":["Rex",",","the","post-transcriptional","regulator","of","human","T-cell","leukemia","virus","type","I","(","HTLV-I",")",",","is","known","to","induce","accumulation","of","the","unspliced","viral","gag-pol","mRNA","."],"ner_tags":[9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,4,4,0]}
{"id":"18391","tokens":["Oncogenicity","of","human","papillomavirus-","or","adenovirus-transformed","cells","correlates","with","resistance","to","lysis","by","natural","killer","cells","."],"ner_tags":[0,0,5,6,6,6,6,0,0,0,0,0,0,7,8,8,0]}
{"id":"241","tokens":["In","this","communication",",","we","provide","evidence","that","the","pathway","of","induction","in","the","macrophage","cell","line","U937","is","different","from","that","in","Jurkat","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,5,0,0,0,0,0,5,6,0]}
{"id":"17663","tokens":["MZF-1","is","a","C2H2","zinc","finger","gene","encoding","a","putative","transcriptional","regulator","of","myeloid","differentiation","."],"ner_tags":[1,0,0,1,2,2,2,0,0,9,10,10,0,0,0,0]}
{"id":"2616","tokens":["Reporter","gene","analysis","reveals","that","the","NF-kappa","B","complex","mobilized","in","tolerant","cells","is","functionally","inactive","in","that","NF-kappa","B-dependent","luciferase","constructs","containing","the","human","immunodeficiency","virus","long","terminal","repeat","or","the","TNF","5'-region","show","only","minimal","transactivation","after","LPS","stimulation","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,5,6,0,0,0,0,0,1,2,2,2,0,0,1,2,2,2,2,2,0,0,1,2,0,0,0,0,0,0,0,0]}
{"id":"13595","tokens":["LPS-binding","protein",",","a","lipid","transfer","protein","found","in","serum",",","facilitates","both","PS","-and","PtdIns-","mCD14","binding","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"4992","tokens":["Following","our","observations","that","A-myb","is","expressed","in","a","restricted","subset","of","normal","mature","human","B","lymphocytes",",","with","the","phenotype","CD38+",",","CD39-",",","slgM-",",","we","have","now","investigated","the","pattern","of","A-myb","expression","in","neoplastic","B","cells","representating","the","whole","spectrum","of","B-cell","differentiation","and","compared","it","to","that","of","c-myb","and","B-myb","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0]}
{"id":"11436","tokens":["Itk",",","a","T","cell-specific","tyrosine","kinase",",","is","required","for","CD2-mediated","interleukin-2","promoter","activation","in","the","human","T","cell","line","Jurkat","."],"ner_tags":[9,0,0,9,10,10,10,0,0,0,0,1,2,2,0,0,0,5,6,6,6,6,0]}
{"id":"12319","tokens":["Our","results","demonstrate","that","the","altered","CCAAT","box","(","CCAAC",")","and","the","lack","of","an","EKLF","binding","site","in","delta-globin","contribute","to","its","low","level","of","expression","in","the","hAEC","model","as","well","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,2,0,9,0,0,0,0,0,0,0,0,0,5,6,0,0,0]}
{"id":"7381","tokens":["MATERIALS","AND","METHODS",":","Human","monocytes","were","stimulated","with","PMA","(","50","ng\/ml",")","alone","or","LPS","(","100","ng\/ml",")","with","and","without","a","nonspecific","serine\/threonine","protein","kinase","inhibitor","staurosporine","(","Stauro",")",",","a","specific","pan-","PKC","inhibitor","bisindolylmaleimide","(","Bis",")",",","or","an","inhibitor","of","PTK","genistein","(","Gen",")","."],"ner_tags":[0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"18328","tokens":["To","understand","the","role","of","MARs","in","IgH","enhancer","regulation",",","we","have","identified","a","novel","MAR-binding","protein",",","MAR-BP1",",","from","soluble","nuclear","matrix","preparations","based","on","its","ability","to","bind","to","the","MARs","associated","with","the","IgH","enhancer","."],"ner_tags":[0,0,0,0,0,9,0,1,2,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,1,2,0]}
{"id":"5461","tokens":["Cloning","and","characterization","of","the","murine","B-cell","specific","transcriptional","coactivator","Bob1","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,9,0]}
{"id":"15814","tokens":["Surprisingly",",","however",",","neither","of","these","proteins","bound","in","vitro","to","EBS1","or","EBS2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0]}
{"id":"16229","tokens":["In","contrast",",","TGF-beta","had","only","minimal","effects","on","two","other","B","cell","membrane","proteins",",","HLA-DR","and","CD20","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,9,10,10,10,0,9,0,9,0]}
{"id":"15420","tokens":["We","have","analysed","the","effect","of","mitogenic","lectins","on","c-Fos","and","c-Jun","protein","levels","as","well","as","on","activator","protein-1","(","AP-1",")","binding","and","enhancer","activity","in","Jurkat","T-cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8655","tokens":["Constitutive","expression","of","human","colony-stimulating","factor-1","receptor","(","CSF-1R",")","confers","long-lasting","CSF-1","-dependent","proliferation","to","mouse","myeloid","cell","lines","."],"ner_tags":[0,0,0,9,10,10,10,0,9,0,0,0,9,0,0,0,5,6,6,6,0]}
{"id":"11729","tokens":["Cellular","redox","status","influences","both","cytotoxic","and","NF-kappa","B","activation","in","natural","killer","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"5857","tokens":["These","results","support","the","feasibility","and","usefulness","of","this","systematic","approach","to","studying","variation","in","gene","expression","patterns","in","human","cancers","as","a","means","to","dissect","and","classify","solid","tumors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9578","tokens":["The","second","complex","contained","RelA",",","and","exhibited","higher","affinity","towards","the","ICAM-1","kappa","B","than","to","the","HIV","kappa","B","site","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,1,2,2,0,0,0,1,2,2,2,0]}
{"id":"17509","tokens":["(","i",")","Acute","transfection","and","expression","of","EBNA-2","under","control","of","simian","virus","40","or","Moloney","murine","leukemia","virus","promoters","resulted","in","increased","LMP1","expression","in","P3HR-1-infected","Burkitt","'s","lymphoma","cells","and","the","P3HR-1","or","Daudi","cell","line","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,1,2,2,2,2,2,2,2,2,0,0,0,9,0,0,5,6,6,6,6,0,0,5,0,5,6,6,0]}
{"id":"10180","tokens":["The","aim","of","this","study","was","to","explore","the","kinetics","of","the","development","of","alterations","in","signal","transduction","molecules","(","TCR","zeta","chain",",","NF","kappaB","family","proteins",",","and","tyrosine","kinase","p56","(","lck",")",")","in","mice","bearing","MC38","colon","adenocarcinoma","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,10,10,0,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0]}
{"id":"11781","tokens":["In","this","report",",","we","demonstrate","that","the","active","form","of","NF-AT1","is","also","present","in","the","nuclei","of","HTLV-I-transformed","T","cells","that","express","the","Tax","protein","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,7,8,8,0,0,0,9,10,0]}
{"id":"5825","tokens":["Erythroid","Kruppel-like","factor","(","EKLF",")",",","which","binds","to","the","CACCC","box","in","the","beta-globin","promoter",",","is","required","for","the","expression","of","the","beta-globin","gene","in","adult","erythroid","cells","."],"ner_tags":[9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,0,7,8,8,0]}
{"id":"3921","tokens":["Based","upon","these","results","we","propose","that","this","factor","may","have","a","role","in","pathophysiology","of","chronic","myeloid","leukaemia","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14785","tokens":["In","comparison",",","UT-7","Epo","cells","expressed","alpha-globin","and","higher","levels","of","gamma-globin","(","5-fold",")","and","beta-globin","(","from","barely","to","clearly","detectable",")","."],"ner_tags":[0,0,0,5,6,6,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"2434","tokens":["All","of","procedure","were","done","in","vitro","."],"ner_tags":[0,0,0,0,0,0,0,0]}
{"id":"11232","tokens":["In","this","study",",","we","examined","early","signaling","events","in","proliferating","and","terminally","differentiated","cells","following","G-CSF","stimulation","to","determine","whether","identical","signaling","cascades","are","activated","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,0,7,8,8,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"17828","tokens":["To","substantiate","these","findings","we","initiated","an","intensified","culturing","procedure","and","were","able","to","establish","LCLs","from","5","out","of","21","consecutive","MS","patients","and","1","out","of","13","consecutive","healthy","controls","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4948","tokens":["In","human","Jurkat","T","cells","and","its","subclone","Wurzburg","cells","oxidant","challenge","elevated","[","Ca2+","]","i","by","mobilizing","Ca2+","from","intracellular","stores","."],"ner_tags":[0,5,6,6,6,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16061","tokens":["A","fragment","extending","from","-643","to","+33","is","capable","of","controlling","the","tissue-specific","expression","of","the","CAT","gene","in","transfection","experiments","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"7986","tokens":["Copyright","1999","Academic","Press","."],"ner_tags":[0,0,0,0,0]}
{"id":"17626","tokens":["We","propose","that","ets-1","functions","as","a","transcriptional","activator","of","mammalian","type-C","retroviruses","and","speculate","that","ets-related","genes","constitute","a","new","group","of","eukaryotic","DNA-binding","proteins","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,9,10,10,0]}
{"id":"9273","tokens":["Human","phagocytes","recognize","bacterial","LPS","(","endotoxin",")","through","membrane","CD14","(","mCD14",")",",","a","proinflammatory","LPS","receptor","."],"ner_tags":[7,8,0,0,0,0,0,0,0,9,10,0,9,0,0,0,9,10,10,0]}
{"id":"13841","tokens":["We","were",",","therefore",",","interested","in","examining","mutated","CIITA","constructs","for","their","effect","on","porcine","MHC","class","II","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,9,10,10,0,0]}
{"id":"5527","tokens":["Signal","transduction","pathways","triggered","by","the","FcepsilonRIIb","receptor","(","CD23",")","in","human","monocytes","lead","to","nuclear","factor-kappaB","activation","."],"ner_tags":[0,0,0,0,0,0,9,10,0,9,0,0,7,8,0,0,9,10,0,0]}
{"id":"2043","tokens":["TF","is","the","primary","cellular","initiator","of","the","coagulation","protease","cascades","."],"ner_tags":[9,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"5304","tokens":["Opposing","effects","of","glucocorticoids","on","the","rate","of","apoptosis","in","neutrophilic","and","eosinophilic","granulocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"2149","tokens":["Internal","ribosome","binding","likely","requires","the","interaction","of","trans-acting","factors","that","recognize","both","the","mRNA","and","the","ribosomal","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,3,0,0,9,10,0]}
{"id":"11290","tokens":["In","MDMs",",","an","upregulation","of","I","kappa","B","alpha","synthesis","as","well","as","the","appearance","of","a","novel","M","(","r",")","40",",","000","form","of","I","kappa","B","alpha","were","also","observed","."],"ner_tags":[0,7,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"5653","tokens":["This","may","explain","the","difference","between","IL-10","and","IFN-gamma","in","biological","activity",",","and","the","inhibitory","effect","of","IL-10","on","IFN-gamma","activities","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,0]}
{"id":"985","tokens":["The","results","indicated","that","both","genes","are","expressed","in","T","cells","throughout","their","development",",","supporting","the","notion","that","PEBP2","is","a","T-cell-specific","transcription","factor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,0,0,9,10,10,0]}
{"id":"18512","tokens":["A","2.3-kb","LCR","in","the","human","adenosine","deaminase","(","ADA",")","gene","first","intron",",","which","controls","expression","in","thymocytes",",","is","composed","of","a","200-bp","enhancer","domain","and","extended","flanking","sequences","that","facilitate","activation","from","within","chromatin","."],"ner_tags":[0,9,10,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,7,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,1,0]}
{"id":"7618","tokens":["[","Corticoids","and","allergy","]"],"ner_tags":[0,0,0,0,0]}
{"id":"18473","tokens":["Interestingly",",","Id2",",","but","not","Id3",",","mRNA","was","strongly","expressed","in","4\/5","T-cell","lines","infected","with","human","T-cell","leukemia","virus","type","I","(","HTLV-I",")","(","ATL-1k",",","MT-2",",","S-LB1",")","and","type","II","(","Mo",")","."],"ner_tags":[0,0,3,0,0,0,3,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,5,0,5,0,5,0,0,0,0,0,5,0,0]}
{"id":"127","tokens":["In","contrast",",","the","promoter","activity","was","suppressed","by","alpha","B2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"17168","tokens":["Induction","of","immediate","early","response","genes","by","macrophage","colony-stimulating","factor","in","normal","human","monocytes","."],"ner_tags":[0,0,1,2,2,2,0,9,10,10,0,7,8,8,0]}
{"id":"14632","tokens":["Potential","phosphorylation","sites","include","the","sequence","PSPTSPT",",","which","resembles","an","RNA","polymerase","II","repeat","reported","to","be","a","target","of","the","cell","cycle","control","kinase","cdc2","."],"ner_tags":[0,9,10,0,0,0,9,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"10474","tokens":["However",",","under","some","conditions",",","engagement","of","the","TCR","leads","instead","to","apoptosis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"364","tokens":["Activation","of","NF-kappa","B","by","various","cellular","stimuli","involves","the","phosphorylation","and","subsequent","degradation","of","its","inhibitor",",","I","kappa","B","alpha",",","although","the","underlying","mechanism","remains","unclear","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0]}
{"id":"12725","tokens":["The","tissular","patterns","of","CIITA","and","MHC","class","II","gene","expression","are","tightly","correlated",":","CIITA","mRNA","is","highly","expressed","in","B","cells",",","and","is","induced","by","interferon","gamma","(","IFN-gamma",")","in","macrophage","and","epithelial","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,7,8,0,0,0,0,0,9,10,0,9,0,0,5,6,6,6,6,0]}
{"id":"11041","tokens":["Transcriptional","induction","of","collagenase-1","in","differentiated","monocyte-like","(","U937",")","cells","is","regulated","by","AP-1","and","an","upstream","C\/EBP-beta","site","."],"ner_tags":[0,0,0,9,0,5,6,6,6,6,6,0,0,0,9,0,0,1,2,2,0]}
{"id":"14636","tokens":["Groups","1","and","2","have","a","serine-rich","region","and","an","``","arginine","element","``","(","RRLPIF",")","at","the","carboxyl","terminus","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,9,10,0,0,9,0,0,0,9,10,0]}
{"id":"5460","tokens":["These","results","suggest","that","the","temporal","control","of","c-Jun","and","c-Fos","may","be","regulated","through","the","ubiquitinylation","pathways",",","and","the","ubiquitinylation","of","c-Jun","and","c-Fos","may","in","turn","be","regulated","in","response","to","the","heterodimerization","between","them","and","the","cooperation","between","E220K","and","E3","mediated","polyubiquitinylation","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"603","tokens":["Transfection","experiments","with","c-myc","promoter","constructs","in","both","DHL-9","and","Raji","cells","revealed","that","the","PuF","site","functioned","as","a","positive","regulatory","element","in","B","cells","with","a","drop","in","activity","with","mutation","of","this","site","."],"ner_tags":[0,0,0,1,2,2,0,0,5,0,5,6,0,0,0,1,2,0,0,0,1,2,2,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6886","tokens":["HIV-1","infects","resting","peripheral","blood","mononuclear","cells","(","PBMCs",")","but","remains","inactive","state","until","subsequent","cell","activation","."],"ner_tags":[0,0,7,8,8,8,8,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"16310","tokens":["USF-related","transcription","factor",",","HIV-TF1",",","stimulates","transcription","of","human","immunodeficiency","virus-1","."],"ner_tags":[9,10,10,0,9,0,0,0,0,0,0,0,0]}
{"id":"12548","tokens":["The","5'-positive","regulatory","unit",",","consisting","of","the","promoter","and","the","5","'","enhancer",",","is","already","active","at","the","CD4","-","CD8","-double-negative","(","DN",")","stage","of","development","."],"ner_tags":[0,1,2,2,0,0,0,0,1,0,0,1,2,2,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0]}
{"id":"7006","tokens":["The","mediator","(","s",")","of","this","maturation","process","has","not","been","yet","defined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2660","tokens":["The","Tax","protein","of","HTLV-I",",","a","positive","transcriptional","activator","of","HTLV-I","gene","expression",",","is","a","viral","oncogene","that","also","increases","transcription","of","cellular","genes","including","GM-CSF",",","IL-2R","alpha","and","IL-2","."],"ner_tags":[0,9,10,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,9,0,9,10,0,9,0]}
{"id":"6429","tokens":["We","measured","the","NF-kappa","B","binding","activity","in","nuclear","extracts","by","gel","shift","analysis","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"15176","tokens":["HL60","cells",",","expressing","some","characteristics","of","promyelocytes",",","can","be","induced","to","monocytoid","differentiation","by","calcitriol","."],"ner_tags":[5,6,0,0,0,0,0,5,0,0,0,0,0,0,0,0,0,0]}
{"id":"4674","tokens":["In","these","cells",",","CD36","is","involved","in","phagocytosis","of","apoptotic","cells",",","and","foam","cell","formation","by","uptake","of","oxidized","low","density","lipoprotein","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"6289","tokens":["Gel","mobility","shift","assays","and","transient","transfection","assays","demonstrate","that","AML1","binds","specifically","to","this","site","in","the","blk","promoter","and","this","binding","site","is","important","for","blk","promoter","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,1,0,0,0]}
{"id":"10879","tokens":["Synthetic","glucocorticoids","that","dissociate","transactivation","and","AP-1","transrepression","exhibit","antiinflammatory","activity","in","vivo","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"8996","tokens":["B","lymphocytes","from","patients","with","chronic","lymphocytic","leukemia","contain","signal","transducer","and","activator","of","transcription","(","STAT",")","1","and","STAT3","constitutively","phosphorylated","on","serine","residues","."],"ner_tags":[7,8,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,10,10,0,9,0,0,0,0,0,0]}
{"id":"9811","tokens":["Analysis","of","myeloid-associated","genes","in","human","hematopoietic","progenitor","cells","."],"ner_tags":[0,0,1,2,0,7,8,8,8,0]}
{"id":"10661","tokens":["Furthermore",",","these","plasmids","were","not","active","in","RJ2.2.5",",","an","in","vitro","mutagenized","derivative","of","Raji","in","which","both","copies","of","CIITA","are","defective","."],"ner_tags":[0,0,0,1,0,0,0,0,5,0,0,0,0,0,0,0,5,0,0,0,0,0,9,0,0,0]}
{"id":"9331","tokens":["We","show","here","that","DTCs","inhibited","both","interleukin","2","(","IL-2",")","synthesis","and","membrane","expression","of","antigens","which","are","induced","during","T-cell","activation","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"16023","tokens":["The","v-erbA","oncoprotein","represents","a","retrovirus-transduced","oncogenic","version","of","the","thyroid","hormone","(","T3\/T4",")","receptor","c-erbA","(","type","alpha",")","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,9,10,10,10,10,10,9,10,10,10,10,0]}
{"id":"14906","tokens":["In","this","regard",",","intracellular","levels","of","c-fos","appear","to","be","influential","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"8123","tokens":["We","introduce","a","new","experimental","system","combining","adenovirus-mediated","gene","transfer","and","fetal","thymic","organ","culture","(","FTOC",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13303","tokens":["Interleukin","1beta","mediates","the","modulatory","effects","of","monocytes","on","LNCaP","human","prostate","cancer","cells","."],"ner_tags":[9,10,0,0,0,0,0,7,0,7,8,8,8,8,0]}
{"id":"6419","tokens":["Host","defense","mechanisms","triggered","by","microbial","lipoproteins","through","toll-like","receptors","."],"ner_tags":[0,0,0,0,0,9,10,0,9,10,0]}
{"id":"15394","tokens":["In","transient","transfection","assays",",","mutant","forms","of","Rev","have","been","identified","that","inhibit","wild-type","Rev","activity","and","therefore","suppress","viral","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"729","tokens":["These","experiments","show","the","presence","of","a","strong","positive-acting","element",",","located","between","-417","and","-207","bp","5","'","to","the","zeta-globin","mRNA","cap","site",",","is","necessary","for","high-level","promoter","activity","in","K562","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,2,2,2,2,0,0,1,2,2,2,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"15385","tokens":["Analysis","of","a","series","of","5'-truncations","showed","several","peaks","of","basal","and","PMA","induced","activity","suggesting","the","presence","of","several","positive","and","negative","regulatory","elements","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0]}
{"id":"5500","tokens":["OBJECTIVE","--","Mammography","and","breast-conserving","therapy","have","focused","attention","on","the","classification","of","intraductal","carcinoma","(","IDC",")","and","emphasized","the","prognostic","importance","of","comedo","versus","noncomedo","variants","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2902","tokens":["PHA","-induced","kappaB-dependent","reporter","activity","was",",","however",",","effectively","blocked","by","a","dominant","negative","form","of","Raf-1",",","suggesting","a","critical","role","for","a","Raf","kinase","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0]}
{"id":"6122","tokens":["In","the","cell","line","HT93A",",","which","is","capable","of","differentiating","towards","both","the","eosinophil","and","neutrophil","lineages","in","response","to","retinoic","acid","(","RA",")",",","C\/EBPalpha","mRNA","expression","decreased","significantly","concomitant","with","eosinophilic","and","neutrophilic","differentiation",",","whereas","C\/EBPbeta","expression","was","markedly","increased","."],"ner_tags":[0,0,5,6,6,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"12358","tokens":["Based","on","the","high","specificity","of","this","compound","for","PKC",",","we","conclude","that","PKC","is","necessary","for","FN","-induced","IL-1beta","protein","production","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,9,0,9,0,0,0]}
{"id":"11913","tokens":["Thus",",","NF-kappa","B",",","a","potent","transcriptional","activator","of","HIV","expression",",","is","also","involved","in","the","expression","of","RANTES",",","a","chemokine","that","blocks","infection","by","macrophage-tropic","strains","of","HIV","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"17120","tokens":["A","novel","B-cell","lineage-specific","transcription","factor","present","at","early","but","not","late","stages","of","differentiation","."],"ner_tags":[0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"5335","tokens":["Activation","of","T","lymphocytes","requires","the","combined","signaling","of","the","T","cell","receptor","and","costimulatory","molecules","such","as","CD28","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,9,10,10,0,9,10,0,0,9,0]}
{"id":"10734","tokens":["gamma-Interferon","-induced","resistance","to","1",",","25-","(","OH",")","2","D3","in","human","monocytes","and","macrophages",":","a","mechanism","for","the","hypercalcemia","of","various","granulomatoses","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"5114","tokens":["A","specific",",","retarded","band","containing","VDR-RXR","was","identified","when","wild","type","cell","but","not","when","vitamin","D-resistant","cell","nuclear","extract","was","used","in","the","binding","reaction","with","either","probe","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17025","tokens":["We","found","that","the","R-responsive","element","is","composed","of","four","protoenhancers","that","span","the","whole","B","domain","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,1,0,0,0,0,1,2,0]}
{"id":"5526","tokens":["The","knowledge","of","the","polyamine","pattern","in","breast","cancer","could","become","useful","in","clinical","practice","particularly","if","polyamine","metabolism","is","targeted","as","a","therapeutic","approach","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1563","tokens":["Finally",",","combined","treatment","of","MT-I","with","5-azacytidine","and","IFN-gamma","induced","re-expression","of","ICAM-I","."],"ner_tags":[0,0,0,0,0,5,0,0,0,9,0,0,0,9,0]}
{"id":"2625","tokens":["A","new","exon","containing","a","highly","basic","region","(","4c",")","was","characterized",",","between","exons","4","and","5","."],"ner_tags":[0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0]}
{"id":"1626","tokens":["Band","A","contains","the","serum","response","factor","plus","additional","factor","(","s",")","."],"ner_tags":[9,10,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"9763","tokens":["NF-kappa","B","binding","activity","can","be","detected","for","several","hours","after","stimulation","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13695","tokens":["Additionally",",","to","determine","the","impact","of","RXR","for","erythroid","cell","development",",","dominant","interfering","mutant","RXRs",",","lacking","the","transcriptional","activator","functions","AF-1","and","AF-2",",","or","AF-2","only",",","or","the","entire","DNA-binding","domain",",","were","introduced","into","erythroid","progenitor","cells","via","recombinant","retrovirus","vectors","and","analyzed","for","RXR","-specific","effects","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,0,9,0,0,9,0,0,0,0,1,2,2,0,0,0,0,7,8,8,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"8944","tokens":["Activation","of","the","LTR","in","Jurkat","cells","was","strongly","enhanced","by","vanadate","and","inhibited","by","catalase",",","implicating","H2O2","."],"ner_tags":[0,0,0,1,0,5,6,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"3137","tokens":["We","conclude","that","different","domains","of","the","pp56","(","lck",")","molecule","contribute","to","regulate","distinct","biologic","functions","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0]}
{"id":"12147","tokens":["Stat6","inhibits","human","interleukin-4","promoter","activity","in","T","cells","."],"ner_tags":[9,0,0,1,2,0,0,7,8,0]}
{"id":"17945","tokens":["Constitutive","overexpression","of","the","L-selectin","gene","in","fresh","leukemic","cells","of","adult","T-cell","leukemia","that","can","be","transactivated","by","human","T-cell","lymphotropic","virus","type","1","Tax","."],"ner_tags":[0,0,0,0,1,2,0,0,7,8,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0]}
{"id":"11428","tokens":["The","development","of","chronic","eosinophilic","inflammation","is","dependent","on","interleukin-5","(","IL-5",")",",","a","selective","eosinophil-activating","factor",",","produced","by","helper","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,9,10,10,0,0,0,7,8,8,0]}
{"id":"18188","tokens":["In","response","to","secondary","pathogenic","infections","or","antigenic","challenge",",","cytokine","gene","expression","is","rapidly","induced",",","enhanced",",","and","sustained","over","prolonged","periods","in","HIV-1-infected","myeloid","cells","compared","with","uninfected","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,7,8,0]}
{"id":"4055","tokens":["The","XPB","mutation","causes","a","severe","NER","defect","."],"ner_tags":[0,9,0,0,0,0,0,0,0]}
{"id":"9135","tokens":["Moreover",",","IL-6","induced","macrophage-differentiation","and","apoptosis","of","1A9-M","cells","."],"ner_tags":[0,0,9,0,0,0,0,0,5,6,0]}
{"id":"4866","tokens":["Both","r-hTBP-1","and","rhu","TNFR",":","Fc","blocked","PMA","induction","of","nuclear","factor","(","NK",")","-","kappa","B","DNA-binding","activity","in","U1","cells","in","association","with","decreases","in","HIV-1","replication","."],"ner_tags":[0,9,0,9,10,10,10,0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,5,6,0,0,0,0,0,0,0,0]}
{"id":"17578","tokens":["Synthesis","of","4",",","19-disubstituted","derivatives","of","DOC","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"5257","tokens":["The","chromosome","17","breakpoint","was","localized","to","intron","2","of","RARA","by","Southern","blotting",",","and","there","was","no","evidence","at","the","molecular","level","for","rearrangement","at","PML","locus","."],"ner_tags":[0,1,2,2,0,0,0,1,2,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"10157","tokens":["The","interleukin-2","IL-2","receptor","beta-chain","(","IL-2Rbeta",")","is","an","essential","component","of","the","receptors","for","IL-2","and","IL-15","."],"ner_tags":[0,9,10,10,10,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"15243","tokens":["Sjogren","'s","syndrome","(","SS",")","is","characterized","by","lymphocytic","infiltrates","of","exocrine","glands",",","remarkable","B","cell","hyperreactivity","and","a","strong","predisposition","to","B","cell","neoplasia","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15217","tokens":["REV","LTRs","work","efficiently","in","human","lymphoid","cells",",","and","are","viable","alternatives","to","promoters","commonly","used","for","expression","of","cloned","genes","."],"ner_tags":[1,2,0,0,0,7,8,8,0,0,0,0,0,0,1,0,0,0,0,0,1,2,0]}
{"id":"17463","tokens":["GCR","on","MNL",",","PML","and","mixed","leucocytes","in","5","patients","were","determined","simultaneously",",","and","all","lowered","from","the","control","group","."],"ner_tags":[9,0,7,0,7,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12412","tokens":["Granzyme","B","gene","transcription","is","induced","in","activated","lymphocytes","upon","antigenic","stimulation",",","and","several","regulatory","regions","including","CBF",",","AP-1",",","and","Ikaros","binding","sites","have","been","shown","to","be","essential","in","the","control","of","granzyme","B","promoter","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,1,2,0,9,0,9,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0]}
{"id":"298","tokens":["DESIGN",":","The","effects","of","hypercortisolaemia",",","hyperthermia","and","cellular","composition","on","number","of","glucocorticoid","receptors","per","cell","and","their","affinity","were","evaluated",",","both","in","vitro","and","in","vivo",",","in","peripheral","blood","mononuclear","leucocytes","of","control","subjects","and","in","patients","with","sepsis","or","septic","shock","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7151","tokens":["The","cytokine","pattern","on","viral","antigen","recognition","is","believed","to","exert","a","profound","influence","on","the","resolution","of","viral","infections","and","viral","clearance","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10890","tokens":["These","results","may","lead","to","an","improvement","of","antiinflammatory","and","immunosuppressive","therapies","and","provide","a","novel","concept","for","drug","discovery","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8843","tokens":["It","is","expressed","as","a","large","67-kDa","precursor","protein","(","pro-IL-16",")","in","lymphocytes",",","macrophages",",","and","mast","cells",",","as","well","as","in","airway","epithelial","cells","from","asthmatics","after","challenge","with","allergen","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,9,0,0,7,0,7,0,0,7,8,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0]}
{"id":"4570","tokens":["125I-IL-13","did","not","bind","to","colon","cancer","cell","lines",",","but","unlabeled","IL-13","competed","for","the","binding","of","125I-IL-4","."],"ner_tags":[9,0,0,0,0,5,6,6,6,0,0,0,9,0,0,0,0,0,9,0]}
{"id":"1008","tokens":["The","number","of","glucocorticoid","receptors","in","peripheral","human","lymphocytes","is","elevated","by","a","zinc","containing","trace","element","preparation","."],"ner_tags":[0,0,0,9,10,0,7,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"17254","tokens":["After","in","vitro","adherence",",","human","monocytes","had","a","biphasic","increase","in","PDGF","(","B",")","mRNA","with","peaks","at","6","h","and","13","d","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,3,4,4,4,4,0,0,0,0,0,0,0,0,0]}
{"id":"12970","tokens":["S9a","inhibited","TNF-alpha","promoter-driven","reporter","gene","activity","."],"ner_tags":[0,0,9,0,1,2,0,0]}
{"id":"17613","tokens":["There","are","at","least","six","isomorphs","of","p56","by","two-dimensional","gel","analysis","."],"ner_tags":[0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"10696","tokens":["Activation","domain","requirements","for","disruption","of","Epstein-Barr","virus","latency","by","ZEBRA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"6621","tokens":["One","of","the","best","understood","apoptotic","pathways","occurs","in","T","lymphocytes","and","is","mediated","by","Fas","\/Fas","ligand","(","FasL",")","interaction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,9,9,10,0,9,0,0,0]}
{"id":"9104","tokens":["Patients","with","diabetic","nephropathy","showed","higher","NF-kappaB","binding","activity","in","Electrophoretic","Mobility","Shift","Assays","and","stronger","immunohistological","staining","for","activated","NF-kappaBp65","than","patients","without","renal","complications","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"1363","tokens":["Northern","blot","analysis","showed","that","neither","of","these","agents","reduced","LPS-stimulated","TF","mRNA","accumulation",",","thereby","suggesting","a","posttranscriptional","mechanism","for","the","effect","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14121","tokens":["Tumors","with","high","Ki-67","proliferation","indices","(",">","20","%",")","were","associated","with","a","higher","4-year","probability","of","relapse","of","disease","(","55.3","%","versus","79.1","%",";","P","=","0.003",")","and","death","(","71","%","versus","95.6","%",";","P","=","0.00005",")","when","compared","with","tumors","with","low","Ki-67","values","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"9072","tokens":["IFN-gamma","and","IL-10","inhibit","induction","of","IL-1","receptor","type","I","and","type","II","gene","expression","by","IL-4","and","IL-13","in","human","monocytes","."],"ner_tags":[9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,7,0]}
{"id":"10995","tokens":["Activation","of","nuclear","factor-kappa","B","by","beta-amyloid","peptides","and","interferon-gamma","in","murine","microglia","."],"ner_tags":[0,0,9,10,10,0,0,0,0,9,0,0,0,0]}
{"id":"10978","tokens":["Consistent","with","this","hypothesis",",","the","short","life","span","was","ameliorated","by","introduction","into","the","EKLF-\/-","ES","cells","of","a","human","LCR\/gamma-globin","gene",",","as","evidenced","by","the","presence","of","ES","cell-derived","reticulocytes","as","well","as","mature","erythrocytes","in","the","blood","of","the","chimeric","animals","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,1,2,2,0,0,0,0,0,0,0,7,8,8,0,0,0,7,8,0,0,0,0,0,0,0,0]}
{"id":"16704","tokens":["The","inactive","precursor",",","lyso-platelet-activating","factor",",","at","a","concentration","as","high","as","10","(","-7",")","M","had","no","effect","on","any","of","the","membrane","phospholipids","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"754","tokens":["At","present",",","not","much","is","known","about","the","molecular","mechanisms","by","which","interleukin-5","(","IL-5",")","exerts","its","diverse","biologic","effects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"6670","tokens":["METHODS",":","Methods","used","in","this","study","include","DNase","I","footprint","assays",",","electrophoretic","mobility","shift","assays",",","and","functional","analysis","by","mammalian","cell","transfection","involving","deletion","analysis","and","site-directed","mutagenesis","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1138","tokens":["At","low","GSSG","levels",",","T","cells","can","not","optimally","activate","the","immunologically","important","transcription","factor","NF","kappa","B",",","whereas","high","GSSG","levels","inhibit","the","DNA","binding","activity","of","NF","kappa","B","."],"ner_tags":[0,0,0,0,0,7,8,0,0,0,0,0,0,0,9,10,9,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"2222","tokens":["Nuclear","factor","kappa","B","(","NF-kappa","B",")","is","a","pleiotropic","transcription","factor","which","is","involved","in","the","transcriptional","regulation","of","several","specific","genes","."],"ner_tags":[9,10,10,10,0,9,10,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12468","tokens":["In","this","study","we","investigated","recognition","by","ovarian","tumor","associated","lymphocyte","(","OVTAL",")",",","and","breast","tumor","associated","lymphocytes","(","BRTAL",")",",","of","peptides","corresponding","to","the","sequence","125-135","of","the","Aminoenhancer","of","split","(","AES",")","protein","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,8,0,7,0,0,0,7,8,8,8,0,7,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,10,10,0]}
{"id":"17383","tokens":["The","age","dependence","of","morphologic","risk","factors","appears","to","explain","the","high","local","failure","rate","seen","in","patients","younger","than","40","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12354","tokens":["U937","cells","transfected","with","the","human","full-length","IL-1beta","promoter","connected","to","a","luciferase","reporter","gene","were","submitted","to","transcription","assays",",","Northern","blotting",",","and","DNA","electrophoresis","mobility","gel","shift","assays","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12909","tokens":["The","present","study","shows","that",",","instead","of","T","cells",",","B","cells","are","generated","in","the","thymus","of","a","line",",","tg","epsilon26",",","of","the","human","CD3epsilon","transgenic","mice","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15370","tokens":["Because","of","the","efficient","binding","of","TG","by","surrogate","receptors","on","non-T","cells",",","we","assessed","the","ability","of","such","cells","to","present","TG","to","T","cells","."],"ner_tags":[0,0,0,0,0,0,9,0,9,10,0,7,8,0,0,0,0,0,0,0,0,0,0,9,0,7,8,0]}
{"id":"7488","tokens":["The","results","indicates","that","carboranes","are","applicable","as","the","hydrophobic","moiety","of","biologically","active","molecules","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17875","tokens":["Moreover",",","STAT5","was","found","to","be","the","predominant","STAT","transcription","factor","used","by","IL-2","in","human","T","cells",",","and","specifically","required","a","COOH-terminal","region","of","IL-2R","beta","(","Ser386-Val525",")",",","while","STAT5","recruitment","was","not","correlated","to","activation","of","IL-2R","gamma","or","JAK3","."],"ner_tags":[0,0,9,0,0,0,0,0,0,9,10,10,0,0,9,0,7,8,8,0,0,0,0,0,9,10,0,9,10,0,9,0,0,0,9,0,0,0,0,0,0,0,9,10,0,9,0]}
{"id":"14248","tokens":["The","human","T-cell","leukemia","virus","type","I","(","HTLV-I",")","and","HTLV-II","Tax","proteins","are","potent","transactivators","of","viral","and","cellular","gene","expression","."],"ner_tags":[0,9,10,10,10,10,10,10,10,10,10,10,10,10,0,0,9,0,0,0,0,0,0,0]}
{"id":"16350","tokens":["Using","amino","acid","sequence","information","derived","from","the","DNA","affinity-purified","protein",",","we","have","now","isolated","cDNA","clones","encoding","TCF-1","alpha","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,1,2,0,9,10,0]}
{"id":"12537","tokens":["This","result","suggests","that","expression","of","Aldh1","protein","is","negatively","regulated","by","Hox11","and","that","abnormal","expression","of","Aldh1","in","Hox11","null","mice","may","cause","loss","of","splenic","precursor","cells","by","aberrant","retinoic","acid","metabolism"],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,9,0,9,0,0,0,0,0,0,7,8,8,0,0,0,0,0]}
{"id":"9917","tokens":["In","previous","work",",","we","identified","an","essential","site","in","the","c-sis\/PDGF-B","promoter",",","Tax-responsive","element","1","(","TRE1",")",",","necessary","for","transactivation","by","Tax","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,1,2,2,0,1,0,0,0,0,0,0,9,0]}
{"id":"489","tokens":["Selective","modulation","of","immune","responsiveness","by","IL-10","in","cells","such","as","monocytes","and","T","cells","may","result","in","part","from","the","differential","activation","of","STAT","protein","pairs","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,7,0,7,8,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"18364","tokens":["Both","phosphorylation","and","proliferation","were","inhibited","by","IL-6","neutralizing","antibodies","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0]}
{"id":"17525","tokens":["These","results","demonstrate","that","the","transcription","of","nuclear","protooncogenes","is","regulated","by","heat","shock","indicating","a","role","for","nuclear","protooncogenes","in","the","stress","response","of","lymphoid","cells","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,7,8,0]}
{"id":"5159","tokens":["DNase","I","footprinting","indicated","that","nuclear","factors","from","activated","T","lymphocytes","bound","a","promoter-proximal","site",",","META","(","P",")",",","and","a","promoter-distal","site",",","META","(","D+",")",",","within","the","400-base","pair","META","region","."],"ner_tags":[9,10,0,0,0,9,10,0,7,8,8,0,0,1,2,0,1,2,2,2,0,0,0,1,2,0,1,2,2,2,0,0,0,1,2,2,2,0]}
{"id":"6476","tokens":["PU.1","represses","GATA-1","-mediated","transcriptional","activation","."],"ner_tags":[9,0,9,0,0,0,0]}
{"id":"14280","tokens":["HIV-1","can","also","establish","a","latent","or","persistent","infection","in","some","T","cell","lines","that","show","minimal","constitutive","virus","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0]}
{"id":"13729","tokens":["We","also","found","differential","expression","of","the","Ca2+-independent","isoforms","in","alveolar","macrophages","compared","with","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,7,8,0,0,7,0]}
{"id":"1581","tokens":["EBV","nuclear","antigen","2","(","EBNA2",")",",","one","of","the","first","genes","expressed","after","EBV","infection","of","B-cells",",","is","a","transcriptional","activator","of","viral","and","cellular","genes","and","is","essential","for","the","transforming","potential","of","the","virus","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1522","tokens":["Steel","factor","affects","SCL","expression","during","normal","erythroid","differentiation","."],"ner_tags":[9,10,0,9,0,0,0,0,0,0]}
{"id":"15268","tokens":["These","data","may","have","implications","for","the","stringent","control","of","IL-4","expression","in","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,0]}
{"id":"3850","tokens":["The","CRE","site","in","the","bcl-2","promoter","appears","to","play","a","major","role","in","the","induction","of","bcl-2","expression","during","the","activation","of","mature","B","cells","and","during","the","rescue","of","immature","B","cells","from","apoptosis","."],"ner_tags":[0,1,2,0,0,1,2,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,8,8,0,0,0,0,0,7,8,8,0,0,0]}
{"id":"3560","tokens":["The","expression","of","GM-CSF","and","IL-2","is","inhibited","by","immunosuppressive","drugs","such","as","cyclosporin","A","(","CsA",")","and","FK506","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2431","tokens":["In","hematopoietic","system",",","RA","and","RARs",",","predominantly","RAR","alpha","may","play","key","roles","for","the","proliferation","and","differentiation","of","hematopoietic","progenitors","."],"ner_tags":[0,0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"13473","tokens":["In","CAT","reporter","constructions","no","appreciable","level","of","CAT","activity","was","supported","by","the","beta","globin","promoter",",","and","only","low","level","activity","by","the","delta","promoter","."],"ner_tags":[0,1,2,2,0,0,0,0,9,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"1144","tokens":["As","HIV-infected","patients","and","SIV-infected","rhesus","macaques","have",",","on","the","average",",","significantly","decreased","plasma","cyst","(","e",")","ine","and","intracellular","GSH","levels",",","we","also","hypothesize","that","AIDS","may","be","the","consequence","of","a","GSSG","deficiency","as","well","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1518","tokens":["The","level","of","constitutive","NF-kappa","B","in","these","cells","is","variable","and","is","frequently","found","to","be","lower","in","the","more","mature","macrophages","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"7219","tokens":["We","recently","reported","that","human","alveolar","macrophages","do","not","express","AP-1","DNA","binding","activity","(","Monick",",","M.","M.",",","Carter",",","A.","B.",",","Gudmundsson",",","G.",",","Geist",",","L.","J.",",","and","Hunninghake",",","G.","W.","(","1998",")","Am.","J.","Physiol.","275",",","L389-L397",")","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2612","tokens":["In","nuclear","run-on","analysis",",","such","tolerant","cells","show","only","a","low","degree","of","transcription",",","indicating","that","tolerance","operates","at","or","upstream","of","the","transcription","level","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10232","tokens":["No","significant","difference","was","detected","in","the","activation","of","MAPK","kinase-1","that","is","induced","by","bufalin","in","wild-type","or","Bcl-2-overexpressed","U937","cells",";","however",",","the","activation","of","MAPK","by","bufalin","was","significantly","attenuated","in","the","cells","overexpressing","Bcl-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"1203","tokens":["It","has","been","reported","that","PKC","is","an","effector","of","p21ras","in","T","cells","."],"ner_tags":[0,0,0,0,0,9,0,0,9,0,1,0,7,8,0]}
{"id":"9374","tokens":["Deletion","of","both","the","-70","to","-65","and","-121","to","-103","regions","of","the","CD11c","promoter","resulted","in","the","loss","of","activation","by","Sp3","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,2,2,0,0,1,2,0,0,0,0,0,0,0,9,0]}
{"id":"17384","tokens":["Tax","-independent","binding","of","multiple","cellular","factors","to","Tax-response","element","DNA","of","HTLV-I","."],"ner_tags":[9,0,0,0,0,9,10,0,1,2,2,0,0,0]}
{"id":"10126","tokens":["We","previously","detected","a","tissue-specific","promoter","preceding","the","exon","encoding","the","N","terminus","of","the","pp52","leukocyte","protein","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,9,10,0,0,9,10,10,0]}
{"id":"4315","tokens":["The","inhibiting","effect","of","IL-4","was","slightly","more","pronounced","than","that","of","IL-10","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"3605","tokens":["Currently","available","data","indicate","that","erythroid","and","megakaryocytic","differentiation","pathways","are","closely","related","to","each","other",",","and","there","may","exist","progenitor","cells","common","to","those","two","lineages","may","exist","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0]}
{"id":"15446","tokens":["Stability","of","the","c-fos","and","c-jun","mRNA","was","not","affected","by","LTB4",",","as","assessed","after","actinomycin","D","treatment","."],"ner_tags":[0,0,0,1,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8377","tokens":["Ligation","of","either","CD80","(","B7-1",")","or","CD86","(","B7-2",")",",","two","principal","ligands","for","CD28",",","is","thought","to","skew","the","immune","response","toward","Th1","or","Th2","differentiation","."],"ner_tags":[0,0,0,9,0,9,0,0,9,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12432","tokens":["Interestingly",",","unlike","NRL","in","rat","mammary","carcinomas",",","no","significant","association","between","NGAL","expression","and","HER-2\/neu","activation","was","found","in","human","breast","tumors","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"210","tokens":["We","observed","that","Fc","gamma","RI","transcript","levels","in","monoblast-like","U937","cells","were","elevated","within","3","hr","and","peaked","12","hr","after","exposure","to","IFN-gamma","."],"ner_tags":[0,0,0,9,10,10,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"1678","tokens":["Retinoids",",","including","all-trans-retinoic","acid",",","its","isomers",",","and","fifty","synthetic","retinoids","(","retinobenzoic","acids",")",",","were","tested","for","differentiation-inducing","activity","on","human","leukemia","cell","lines","HL-60","and","NB4","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,5,0,5,0]}
{"id":"5563","tokens":["Phosphorylated","Bcl-2","can","not","bind","calcineurin",",","and","NFAT","activation",",","FasL","expression",",","and","apoptosis","can","occur","after","Bcl-2","phosphorylation","."],"ner_tags":[0,9,0,0,0,9,0,0,9,0,0,9,0,0,0,0,0,0,0,9,0,0]}
{"id":"8410","tokens":["The","present","study","examined","the","molecular","mechanism","of","this","inhibition","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15844","tokens":["We","have","previously","identified","a","T","lymphocyte","protein","which","binds","to","a","site","within","the","LTR","of","the","human","immunodeficiency","virus","type","1","(","HIV-1",")","and","exerts","an","inhibitory","effect","on","virus","gene","expression","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12810","tokens":["Expression","of","an","active","form","of","Ras",",","Ras","(","G12V",")",",","suppressed","the","IL-2","-induced","beta-casein","and","OSM","gene","expression",",","and","the","negative","effect","of","Ras","is","mediated","by","the","region","between","-105","and","-193","in","the","beta-casein","promoter","."],"ner_tags":[0,0,0,0,0,0,9,0,9,10,10,10,0,0,0,9,0,9,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,1,2,2,0,0,1,2,0]}
{"id":"17844","tokens":["T","cells","lack","active","NF-kappa","B","but","express","Sp1","as","expected","."],"ner_tags":[7,8,0,0,9,10,0,0,9,0,0,0]}
{"id":"6578","tokens":["Multiple","NF-ATc","isoforms","with","individual","transcriptional","properties","are","synthesized","in","T","lymphocytes","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,7,8,0]}
{"id":"1375","tokens":["We","have","detected","a","specific","nuclear","protein","complex","that","binds","to","the","element","and","show","that","NF-kappa","B1","(","p50",")","is","a","part","of","this","complex","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0]}
{"id":"3150","tokens":["A","second","messenger","cascade","involved","is","the","inositol-1",",","4",",","5-trisphosphate\/calcium","pathway","which","responds","over","the","same","rapid","time","course","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2738","tokens":["Multiple","TRAF3","binding","sites","containing","a","PXQXT\/S","core","sequence","can","be","identified","in","the","simian","EBV","LMP1s","by","an","in","vitro","binding","assay","."],"ner_tags":[0,1,2,2,0,0,1,2,2,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"462","tokens":["We","have","found","that","stimulation","of","any","one","of","these","pathways","alone","has","little","or","no","effect","on","c-fos","induction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]}
{"id":"16069","tokens":["Lymphocyte","glucocorticoid","receptor","binding","parameters","were","studied","in","15","severely","depressed","patients","during","depression","and","after","clinical","recovery",",","and","in","15","healthy","controls","."],"ner_tags":[9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8540","tokens":["Fas","(","CD95",")","and","Fas","ligand","(","CD95L",")","are","an","interacting","receptor-ligand","pair","required","for","immune","homeostasis","."],"ner_tags":[9,0,9,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11208","tokens":["Physical","and","functional","interaction","between","the","human","T-cell","lymphotropic","virus","type","1","Tax1","protein","and","the","CCAAT","binding","protein","NF-Y","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,0,9,10,10,9,0]}
{"id":"5528","tokens":["BACKGROUND",":","Alveolar","macrophages","play","a","key","role","in","the","initiation","of","the","inflammatory","reaction","of","allergic","asthma","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11893","tokens":["This","interaction","is","mediated","by","the","Ets","domain","of","Ets","proteins","and","the","C-terminal","region","of","the","Rel","homology","domains","of","NF-kappaB\/NFAT","proteins","."],"ner_tags":[0,0,0,0,0,0,1,2,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"15646","tokens":["In","the","TCR","alpha","beta","lineage",",","however",",","the","final","gene","rearrangement","events","are","accompanied","by","rapid","proliferation","and","an","interruption","in","cellular","response","gene","inducibility","."],"ner_tags":[0,0,7,8,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16823","tokens":["At","high","concentration","of","NE",",","all","of","the","TR","bound","to","TREp","was","more","greatly","retarded","than","in","the","absence","of","NE","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8828","tokens":["Clonality","of","isolated","eosinophils","in","the","hypereosinophilic","syndrome","."],"ner_tags":[0,0,7,8,0,0,0,0,0]}
{"id":"7900","tokens":["A","transfected","IFN-beta","promoter","responded","to","EBNA2","activation",",","and","a","sequence","closely","resembling","a","RBP-Jkappa","binding","site","was","pinpointed","as","a","potential","target","of","EBNA2","activity","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,9,0,0]}
{"id":"6560","tokens":["When","a","drug","appears","to","be","less","effective","than","preclinical","models","suggest",",","can","failures","in","effectiveness","from","delivery","or","dosing","be","differentiated","?","The","disappointing","results","of","clinical","trials","with","IL-10","--","so","at","odds","with","the","prediction","of","benefit","from","animal","models","--","bring","into","question","the","validity","of","those","models","as","well","as","the","soundness","of","design","of","the","clinical","trials","on","which","efficacy","of","IL-10","is","judged","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"13669","tokens":["Transcription","factor","activation","in","lymphokine","activated","killer","cells","and","lymphocytes","from","patients","receiving","IL-2","immunotherapy","."],"ner_tags":[9,10,0,0,0,0,7,8,0,7,0,0,0,9,0,0]}
{"id":"602","tokens":["We","demonstrated","by","electrophoretic","mobility","shift","assay",",","electrophoretic","mobility","shift","assay","with","antibody",",","UV","cross-linking","followed","by","SDS-gel","electrophoresis",",","and","Western","analysis","that","Nm23H2","in","B","cell","nuclear","extracts","bound","to","the","c-myc","PuF","site","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"9533","tokens":["The","role","of","the","viral","trans-activator","Tax","protein","in","the","induction","of","VCAM-1","was","first","indicated","by","the","detection","of","this","adhesion","molecule","on","Jurkat","T-cell","clones","stably","expressing","the","tax","gene","."],"ner_tags":[0,0,0,0,9,10,10,10,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0,5,6,6,0,0,0,0,0,0]}
{"id":"4421","tokens":["Constitutively","active","MAPKK-1","fully","activates","ERK-2","and","the","transcription","factor","Elk-1",",","but","does","not","substitute","for","activated","p21ras","and","synergize","with","calcium","\/calcineurin","signals","to","induce","NFAT","."],"ner_tags":[0,0,9,0,0,9,0,0,9,10,9,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,9,0]}
{"id":"17939","tokens":["Males","with","X-linked","severe","combined","immunodeficiency","(","XSCID",")","have","defects","in","the","common","cytokine","receptor","gamma","chain","(","gamma","c",")","gene","that","encodes","a","shared",",","essential","component","of","the","receptors","of","interleukin-2","(","IL-2",")",",","IL-4",",","IL-7",",","IL-9",",","and","IL-15","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,0,9,0,9,0,0,9,0]}
{"id":"8734","tokens":["In","an","effort","to","identify","this","factor",",","the","cellular","levels","of","components","of","the","GR","heterocomplex","in","SML","and","human","lymphocytes","(","HL",")","were","compared","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,0,7,8,0,7,0,0,0,0]}
{"id":"1878","tokens":["Epstein-Barr","virus","(","EBV",")","replicative","gene","expression","in","tumour","cells","of","AIDS-related","non-Hodgkin","'s","lymphoma","in","relation","to","CD4","cell","number","and","antibody","titres","to","EBV","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"4627","tokens":["COS-1","cells",",","co-expressing","the","human","IL-10R","and","individual","STAT","proteins",",","confirmed","a","preference","of","the","IL-10R","for","STAT3","and","STAT1","."],"ner_tags":[5,6,0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,9,0,9,0,9,0]}
{"id":"8856","tokens":["Homozygotes","for","a","polymorphism","at","codon","352","(","genotype","tt",")","were","significantly","underrepresented","among","those","with","tuberculosis","(","chi2=6.22",",","1","df",",","P=.01",")","and","persistent","hepatitis","B","infection","(","chi2=6.25",",","1","df",",","P=.01",")","but","not","in","subjects","with","clinical","malaria","compared","with","the","other","genotypes","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12626","tokens":["Furthermore",",","a","TAL1","mutant","not","binding","to","DNA","also","activated","the","transcription","of","RALDH2","in","the","presence","of","LMO","and","GATA3","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,9,0]}
{"id":"18074","tokens":["Three","binding","sites","for","C\/EBP","proteins","are","found","in","the","human","immunodeficiency","virus","type","1","(","HIV-1",")","long","terminal","repeat","(","LTR",")","(","V.M.","Tesmer",",","A.Rajadhyaksha",",","J.Babin",",","and","M.Bina",",","Proc.Natl.Acad.Sci.","USA","90",":","7298-7302",",","1993",")","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12868","tokens":["However",",","little","is","known","about","the","structure-activity","relationship","and","the","mechanism","by","which","endotoxin","induces","Mn","SOD","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"969","tokens":["The","human","interleukin-3","(","IL-3",")","gene","is","expressed","almost","exclusively","in","activated","T","cells","."],"ner_tags":[0,1,2,2,2,2,2,0,0,0,0,0,0,7,8,0]}
{"id":"7690","tokens":["For","that","purpose",",","we","established","several","lines","of","transgenic","mice","displaying","erythroid-specific","expression","of","a","thermosensitive","SV40","T","antigen","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"6752","tokens":["IL-4R","are","thought","to","be","composed","of","the","IL-4R","alpha","chain","(","IL-4R","alpha",")","and","either","the","IL-2R","gamma","chain","or","the","IL-13R","alpha","chain","."],"ner_tags":[9,0,0,0,0,0,0,0,9,10,10,0,9,10,0,0,0,0,9,10,10,0,0,9,10,10,0]}
{"id":"8971","tokens":["These","studies","demonstrate","a","novel","and","striking","insensitivity","of","arterial","endothelium","to","the","effects","of","TNF","and","LPS","and","indicate","a","dissociation","between","the","ability","of","HUAECs","to","upregulate","nuclear","factor-kappaB","and","VCAM-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,7,0,0,9,10,0,9,0]}
{"id":"10049","tokens":["Our","results","support","an","important","role","for","autocrine","TNF-alpha","secretion","in","controlling","HIV","replication","in","primary","T","cells","because","of","its","ability","to","maintain","NF-kappa","B","elevated","in","the","nucleus","of","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,9,10,0,0,0,0,0,7,8,0]}
{"id":"11784","tokens":["These","results","suggest","that","activation","of","NF-AT1","in","Tax-expressing","and","HTLV-I-transformed","T","cells","results","from","its","dephosphorylation",",","which","in","turn","may","be","due","to","deregulation","of","calcineurin"],"ner_tags":[0,0,0,0,0,0,9,0,5,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9]}
{"id":"15694","tokens":["Gel","retardation","assays",",","using","a","32P-probe","containing","the","HIV-1","NF-kB","probe","and","nuclear","extracts","from","PMA-treated","cells",",","showed","significantly","reduced","induction","of","nuclear","NF-kB","binding","proteins","in","these","two","subclones","compared","with","wild","type","CEM","and","a","control","subclone","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,8,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"8418","tokens":["Thirteen","preterms","of","the","latter","group","received","prenatal","steroid","treatment","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2790","tokens":["Furthermore",",","the","BCL-6","rearrangements","can","be","used","to","identify","and","monitor","the","malignant","clone","with","sensitive","PCR-based","techniques","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0]}
{"id":"291","tokens":["Recently",",","transcription","factors","known","as","STATs","(","signal","transducers","and","activators","of","transcription",")","have","been","shown","to","be","tyrosine","phosphorylated","and","activated","in","response","to","a","number","of","cytokines","that","bind","hematopoietin","receptors","and","activate","JAK","kinases","."],"ner_tags":[0,0,9,10,0,0,9,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,0,0,9,10,0]}
{"id":"5248","tokens":["The","Epstein-Barr","virus-encoded","nuclear","antigen","EBNA-5","accumulates","in","PML-containing","bodies","."],"ner_tags":[0,9,10,10,10,10,0,0,0,0,0]}
{"id":"7594","tokens":["In","contrast",",","aspirin","was","found","to","lower","the","risk","of","myocardial","infarction","in","men","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10209","tokens":["Further","analysis","has","revealed","that","this","1-kb","fragment","promotes","higher","reporter","gene","activity","in","MNDA","-expressing","cells","than","non-expressing","cells",",","indicating","cell-specific","differences","in","transactivation","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,0,0,0,0,9,7,8,0,7,8,0,0,0,0,0,0,0]}
{"id":"290","tokens":["We","have","recently","demonstrated","that","stimulation","of","human","T","and","natural","killer","cells","with","IL-12","induces","tyrosine","phosphorylation","of","the","Janus","family","tyrosine","kinase","JAK2","and","Tyk2",",","implicating","these","kinases","in","the","immediate","biochemical","response","to","IL-12","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,8,8,8,0,9,0,0,0,0,0,9,10,10,10,9,0,9,0,0,0,9,0,0,0,0,0,0,9,0]}
{"id":"14704","tokens":["The","L","gene","produces","the","erythroid","(","R-PK",")","or","the","hepatic","(","L-PK",")","isozymes","by","the","alternative","use","of","two","promoters","."],"ner_tags":[0,1,2,0,0,9,0,9,0,0,0,9,10,10,10,10,0,0,0,0,0,0,1,0]}
{"id":"4293","tokens":["Inhibition","of","transcription","factor","Stat1","activity","in","mononuclear","cell","cultures","and","T","cells","by","the","cyclic","AMP","signaling","pathway","."],"ner_tags":[0,0,9,10,9,0,0,5,6,6,0,7,8,0,0,0,0,0,0,0]}
{"id":"10295","tokens":["Molecular","cloning","of","SLAP-130",",","an","SLP-76-associated","substrate","of","the","T","cell","antigen","receptor-stimulated","protein","tyrosine","kinases","."],"ner_tags":[0,0,0,9,0,0,9,10,0,0,9,10,10,10,10,10,10,0]}
{"id":"13707","tokens":["For","example",",","the","analysis","of","only","1","signaling","molecule","may","allow","patients","with","significant","defects","in","T-cell","signaling","to","go","unnoticed","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13464","tokens":["However",",","results","of","intracellular","staining","and","dual","color","confocal","microscopy","revealed","a","significant","defect","in","transport","of","newly","synthesized","class","II","molecules","through","the","endocytic","compartment","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"16264","tokens":["HL-60","cells","were","cultured","with","10","(","-7",")","mol\/L","1",",","25","(","OH",")","2D3","for","24","to","72","hours",",","and","levels","of","expression","of","1",",","25","(","OH",")","2D3","receptor","and","its","RNA","were","examined","."],"ner_tags":[5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0]}
{"id":"9659","tokens":["These","data","support","the","conclusion","that","CN","activity","is","rate-limiting","for","the","activation","of","primary","human","T","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"16686","tokens":["Second",",","by","high","stringency","Northern","blotting","and","in","situ","hybridization",",","TCF-1","expression","was","shown","to","be","confined","to","the","thymus","and","to","the","T","cell","areas","of","the","spleen","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15250","tokens":["No","correlation","was","observed","between","c-myc","mRNA","and","B","lymphocyte","monoclonicity","or","lymphoma","."],"ner_tags":[0,0,0,0,0,3,4,0,0,0,0,0,0,0]}
{"id":"16908","tokens":["Our","results","suggest","that","high","estrogen","and","anti-estrogen","concentrations","and","flavonoids","may","regulate","IM-9","cell","growth","through","a","common","mechanism","involving","a","binding","interaction","with","type-II","EBS","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8753","tokens":["GCs","induce","apoptosis","in","neoplastic","lymphoid","cells",";","and",",","defective","apoptosis","is","implicated","in","the","genesis","of","chronic","lymphocytic","leukemia","(","CLL",")","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3672","tokens":["The","identification","of","oriP","and","the","EBNA2-dependent","enhancer","as","the","major","positive","cis","elements","involved","in","regulating","Cp","activity","in","LCL","suggests","that","EBNA","gene","transcription","is","largely","autoregulated","by","EBNA","1","and","EBNA","2","."],"ner_tags":[0,0,0,1,0,0,1,2,0,0,0,0,1,2,0,0,0,1,0,0,5,0,0,1,2,0,0,0,0,0,9,10,0,9,10,0]}
{"id":"18142","tokens":["DNA","binding","specificity","of","complex","3","overlaps","with","that","of","upstream","stimulatory","factor","but","is","clearly","distinct","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"953","tokens":["To","determine","whether","EBNA-2","also","trans-activates","the","LMP","promoter","by","protein-protein","interactions",",","we","performed","a","series","of","gel","retardation","assays","and","competition","experiments","with","LMP","promoter","fragments","of","different","sizes","."],"ner_tags":[0,0,0,9,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0]}
{"id":"17408","tokens":["Cyclosporin","A","and","FK506","are","immunosuppressive","compounds","that","have","similar","inhibitory","effects","on","the","expression","of","several","lymphokines","produced","by","T","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,0]}
{"id":"3849","tokens":["Although","the","CRE","site","is","necessary",",","optimal","induction","of","bcl-2","expression","requires","participation","of","the","upstream","regulatory","element",",","suggesting","that","phosphorylation","of","CREB","alters","its","interaction","with","the","upstream","regulatory","element","."],"ner_tags":[0,0,1,2,0,0,0,0,0,0,9,0,0,0,0,0,1,2,2,0,0,0,0,0,9,0,0,0,0,0,1,2,2,0]}
{"id":"13598","tokens":["Protein","kinase","C","regulates","Fas","(","CD95\/APO-1",")","expression","."],"ner_tags":[9,10,10,0,9,0,9,0,0,0]}
{"id":"12845","tokens":["These","responses","were","completely","blocked","by","tyrosine","kinase","inhibitors","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0]}
{"id":"12270","tokens":["Requirement","of","prestimulated","THP-1","monocytic","cells","for","endothelial","cell","activation","."],"ner_tags":[0,0,5,6,6,6,0,7,8,0,0]}
{"id":"5080","tokens":["To","study","transcriptional","regulation","in","normal","human","T","cells",",","we","have","optimized","conditions","for","transient","transfection","."],"ner_tags":[0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0]}
{"id":"7702","tokens":["Fludarabine","caused","a","specific","depletion","of","STAT1","protein","(","and","mRNA",")","but","not","of","other","STATs","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,0]}
{"id":"17652","tokens":["They","propose","that","BSAP","is","a","key","protein","of","B","cells","and","that","it","not","only","influence","B-cell","development","but","also","influences","the","balance","between","B-cell","proliferation","and","immunoglobulin","secretion","at","later","stages","of","B-cell","differentiation","."],"ner_tags":[0,0,0,9,0,0,9,10,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"10388","tokens":["The","current","study","investigates","the","hypothesis","that","CD40","expressed","on","lung","fibroblasts","is","an","activation","structure","and","mechanism","for","interaction","with","hemopoietic","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,7,8,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"938","tokens":["Cell","lines","that","expressed","MNDA","exhibited","myeloid","cell","features","and","granulocyte","or","monocyte","differentiation","could","be","induced","in","vitro",",","while","cell","lines","exhibiting","properties","of","very","early","stage","cells","or","multipotential","cells","did","not","express","MNDA","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,9,0]}
{"id":"4628","tokens":["Unlike","many","hematopoietin","receptors",",","the","IL-10R","did","not","detectably","activate","STAT5","."],"ner_tags":[0,0,9,10,0,0,9,0,0,0,0,9,0]}
{"id":"5220","tokens":["CIITA","and","Bob1","interact","with","proteins","that","bind","to","conserved","upstream","sequences","in","promoters","of","class","II","major","histocompatibility","genes","and","octamer-binding","transcription","factors","Oct-1","and","Oct-2",",","respectively","."],"ner_tags":[9,0,9,0,0,0,0,0,0,1,2,2,0,1,0,1,2,2,2,2,0,9,10,10,9,0,9,0,0,0]}
{"id":"2647","tokens":["S6","was","cleaved","with","CNBr","and","three","internal","peptides","were","sequenced","."],"ner_tags":[9,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"2659","tokens":["Molecular",",","biochemical","and","epidemiological","evidence","implicate","HTLV-I","as","an","etiologic","agent","of","adult","T","cell","leukemia","(","ATL",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9143","tokens":["Therefore",",","activation","of","Stat3","is","essential","for","IL-6","-induced","macrophage-differentiation","and","programmed","cell","death","in","this","model","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"17722","tokens":["One","of","the","most","important","cytokines","involved","in","immune","response","regulation","is","interleukin","2","(","IL-2",")",",","a","potent","activator","of","the","proliferation","and","function","of","T","lymphocytes","and","natural","killer","cells","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,8,8,0]}
{"id":"1381","tokens":["A","similar","increase","in","IL-2R","alpha","by","TG","was","also","observed","in","human","peripheral","T","cells","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"5650","tokens":["IL-10","inhibited","IFN-gamma","-induced","STAT","activation","without","newly","synthesized","protein","."],"ner_tags":[9,0,9,0,9,0,0,9,10,10,0]}
{"id":"7602","tokens":["All","agents","tested","induced","expression","of","Hsp60","6","hr","after","application","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"3319","tokens":["Mutation","of","either","site","reduced","the","expression","in","transient","transfection","experiments","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10926","tokens":["No","modification","of","c-myc","expression","could","be","detected","on","treatment","with","histamine","or","its","analogues","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11032","tokens":["The","SRG3","protein","contains","an","acidic","NH2","terminus",",","a","myb-like","DNA","binding","domain",",","a","leucine-zipper","motif",",","and","a","proline-","and","glutamine-rich","region","at","its","COOH","terminus","."],"ner_tags":[0,9,10,0,0,9,10,10,0,0,9,10,10,10,0,0,9,10,0,0,0,9,10,10,10,0,0,9,10,0]}
{"id":"8207","tokens":["Northern","analysis","demonstrated","increased","IL-2Ralpha","gene","expression","after","stimulation","with","M.","tuberculosis","which","was","further","induced","by","interferon-gamma","(","IFN-gamma",")","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0]}
{"id":"13319","tokens":["We","have","previously","shown","that","the","transcription","factor","GATA-3","is","expressed","in","Th2","but","not","Th1","cells","and","is","crucial","for","activation","of","the","IL-5","promoter","by","different","stimuli","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0,5,6,6,6,6,0,0,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"7828","tokens":["These","results","indicate","that","CD40","-CD40L","interactions","may","play","an","important","role","in","augmenting","antitumor","immunity","and","inducing","apoptosis","in","some","CD40","-positive","immunogenic","human","MMs","."],"ner_tags":[0,0,0,0,9,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"2417","tokens":["A","basis","for","differentiation","therapy","of","leukemias","is","provided","by","knowledge","of","agents","which","induce","specific","lineage","maturation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8964","tokens":["Interleukin-1","stimulated","U-937","cell","adhesion","to","and","VCAM-1","surface","expression","in","both","HUVECs","and","HUAECs","."],"ner_tags":[9,0,5,6,0,0,0,9,0,0,0,0,7,0,7,0]}
{"id":"4662","tokens":["The","activating","and","inhibitory","domains","function","together","as","an","independent","regulatory","module","in","different","cell","types","as","shown","by","fusion","to","the","GAL4","DNA","binding","domain","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"6108","tokens":["In","contrast",",","a","constitutively","active","SHP2-DeltaSH2","had","no","statistically","significant","effect","(","although","it","caused","a","slight","augmentation","in","some","individual","experiments",")","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9804","tokens":["This","sensitization","is","dependent","on","the","TRAF-binding","sites","within","the","CD30","cytoplasmic","domain","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,9,9,10,0]}
{"id":"3637","tokens":["E3",",","one","of","nine","sequences","identified",",","was","upregulated","in","an","immediate-early","manner",",","with","transcript","levels","peaking","after","60","minutes","exposure","to","RA","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11984","tokens":["A","molecular","basis","for","the","pathogenesis","of","X-linked","severe","combined","immunodeficiency","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"705","tokens":["The","HEL","cells","also","exhibited","a","similar","elevation","of","AhR","mRNA","level",",","when","they","had","differentiated","toward","monocyte-macrophage","cells","by","these","combined","inducers",",","but","little","change","in","the","mRNA","level","was","observed","when","the","cells","were","induced","to","differentiate","into","other","cell","types","."],"ner_tags":[0,5,6,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14481","tokens":["In","contrast","to","the","type","I","receptor",",","the","type","II","IL-1R","has","a","small","cytoplasmic","tail",",","and","it","is","not","clear","whether","this","receptor","is","a","signal-transducing","or","a","regulatory","molecule","."],"ner_tags":[0,0,0,0,9,10,10,0,0,9,10,10,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,0]}
{"id":"4481","tokens":["The","human","T-cell","leukemia","virus","type","1","posttranscriptional","trans-activator","Rex","contains","a","nuclear","export","signal","."],"ner_tags":[0,9,10,10,10,10,10,10,10,9,0,0,9,10,10,0]}
{"id":"15776","tokens":["Later",",","the","expression","of","the","BSAP","gene","shifts","to","the","fetal","liver","where","it","correlates","with","the","onset","of","B","lymphopoiesis","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17809","tokens":["The","tumour","suppressor","p53","has","been","shown","to","regulate","this","type","of","apoptosis","in","thymocytes",",","but","an","as","yet","unknown",",","p53","-independent","pathway","(","s",")","appears","to","mediate","the","same","event","in","mitogen-activated","mature","T","lymphocytes","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"2601","tokens":["No","evidence","for","the","expression","of","the","progesterone","receptor","on","peripheral","blood","lymphocytes","during","pregnancy","[","see","comments","]"],"ner_tags":[0,0,0,0,0,0,0,9,10,0,7,8,8,0,0,0,0,0,0]}
{"id":"8235","tokens":["Neither","cell","population","generated","significant","amounts","of","E2","from","E1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9129","tokens":["Incubation","of","endothelial","cells","with","oleate","for","72","hours","decreased","the","relative","proportions","of","saturated","(","palmitic","and","stearic",")","acids","in","total","cell","lipids","and","increased","the","proportions","of","oleate","in","total","cell","lipids","without","significantly","changing","the","relative","proportions","of","polyunsaturated","fatty","acids","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9059","tokens":["These","observations","indicate","that","primary","T","cell","responses","detected","in","vitro","using","DC","as","APC","may","be","useful","to","characterize","the","potential","immunogenicity","of","viral","protein","epitopes","in","vivo","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2300","tokens":["A","52-year-old","female","presented","with","a","progressively","enlarging","vulvar","mass","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4705","tokens":["All","three","types","of","H-RS","cell","lines","were","consistently","negative","for","BSAP",",","TCF-1",",","and","GATA-3","."],"ner_tags":[0,0,0,0,5,6,6,0,0,0,0,9,0,9,0,0,9,0]}
{"id":"8208","tokens":["The","IL-2Ralpha","promoter","containing","the","nuclear","factor","kappa","B","(","NF-kappaB",")","site","was","transcriptionally","induced","by","M.","tuberculosis","and","this","NF-kappaB","site","could","confer","inducibility","to","a","heterologous","herpes","thymidine","kinase","(","TK",")","promoter","by","M.","tuberculosis","."],"ner_tags":[0,1,2,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0]}
{"id":"5126","tokens":["Despite","these","similar","mRNA","levels",",","BCL-6","protein","expression","was","threefold","to","34-fold","higher","in","germinal","center","B","cells","than","in","resting","B","cells",",","suggesting","that","BCL-6","protein","levels","are","controlled","by","translational","or","posttranslational","mechanisms","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,8,8,0,0,7,8,8,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"1313","tokens":["A","factor","that","regulates","the","class","II","major","histocompatibility","complex","gene","DPA","is","a","member","of","a","subfamily","of","zinc","finger","proteins","that","includes","a","Drosophila","developmental","control","protein","."],"ner_tags":[0,0,0,0,0,1,2,2,2,2,2,1,0,0,0,0,0,0,0,9,10,10,0,0,0,9,10,10,10,0]}
{"id":"3378","tokens":["This","in","turn","leads","to","the","nuclear","association","of","the","cytosolic","component","of","NF-ATc","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,9,0]}
{"id":"14004","tokens":["The","functional","effects","of","these","interactions","are","that","CBP","and","p300",",","but","not","P\/CAF",",","enhance","EKLF","'s","transcriptional","activation","of","the","beta-globin","promoter","in","erythroid","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,9,0,0,9,0,0,0,0,0,1,2,0,7,8,0]}
{"id":"7967","tokens":["In-situ","detection","of","fragmented","DNA","was","performed","to","identify","apoptotic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"6391","tokens":["A","second","peak","was","observed","at","a","later","time","point","following","LPS","stimulation",",","which","consisted","of","both","IKK-alpha","and","-beta","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4098","tokens":["Thus",",","through","the","differential","use","of","the","same","promoter","element",",","the","composite","kappa","3\/CRE","site",",","the","TNF-alpha","gene","is","regulated","in","a","cell-type-specific","manner","in","response","to","the","same","extracellular","signal","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,1,2,2,2,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13195","tokens":["Moreover",",","impaired","activation","of","NFkappaB","does","not","appear","linked","to","a","reduction","of","TCRzeta","expression",",","because","in","five","patients",",","normal","TCRzeta","levels","were","present","although","kappaB","binding","was","not","inducible","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0]}
{"id":"10497","tokens":["Six","PTT","shifts","were","identified","."],"ner_tags":[0,0,0,0,0,0]}
{"id":"10502","tokens":["Confirmed","mutations","were","identified","in","28","%","of","the","families","studied","and","on","the","assumption","that","half","of","the","sporadic","cases","should","have","TSC2","mutations",",","a","crude","estimate","of","the","detection","rate","would","be","60","%","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8572","tokens":["This","A\/R-induced","hyperadhesion","is","completely","prevented","by","a","previous","(","24","hours","earlier",")","exposure","of","HUVECs","to","A\/R","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,0,0]}
{"id":"2316","tokens":["In","both","cell","lines","LIF","increased","NF-kB","activity","."],"ner_tags":[0,0,0,0,9,0,9,0,0]}
{"id":"9124","tokens":["The","endothelial","expression","of","vascular","cell","adhesion","molecule-1","(","VCAM-1",")",",","E-selectin",",","and","intercellular","adhesion","molecule-1","was","monitored","by","cell","surface","enzyme","immunoassays","or","flow","cytometry",",","and","steady-state","levels","of","VCAM-1","mRNA","were","assessed","by","Northern","blot","analysis","."],"ner_tags":[0,0,0,0,9,10,10,10,0,9,0,0,9,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0]}
{"id":"16048","tokens":["The","KBF1","factor",",","which","binds","to","the","enhancer","A","located","in","the","promoter","of","the","mouse","MHC","class","I","gene","H-2Kb",",","is","indistinguishable","from","the","p50","DNA","binding","subunit","of","the","transcription","factor","NF-kappa","B",",","which","regulates","a","series","of","genes","involved","in","immune","and","inflammatory","responses","."],"ner_tags":[0,9,10,0,0,0,0,0,1,2,0,0,0,1,0,0,1,2,2,2,2,1,0,0,0,0,0,9,10,10,10,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9817","tokens":["All","other","molecules","studied","were","found","to","be","expressed","at","this","stage","of","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4609","tokens":["Tissue","specific","regulation","of","gene","expression","by","transcription","factors","is","a","fascinating","new","field","in","molecular","immunology","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"16716","tokens":["Furthermore",",","a","mutant","E6","motif","lost","both","in","vitro","binding","activity","and","in","vivo","enhancer","activity","."],"ner_tags":[0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16804","tokens":["PMA","treatment",",","and","not","retinoic","acid","treatment","of","the","U937","cells","acts","in","inducing","NF-KB","expression","in","the","nuclei","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,9,0,0,0,0,0]}
{"id":"16505","tokens":["Taken","together",",","the","results","indicate","that","M-CSF","treatment","is","associated","with","differential","activation","of","multiple","members","of","the","jun\/fos","family","and","that","expression","of","these","genes","could","contribute","to","nuclear","signaling","mechanisms","that","regulate","a","specific","program","of","monocyte","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4162","tokens":["Estrogen","may","participate","in","the","pathogenesis","of","systemic","lupus","erythematosus","(","SLE",")","via","its","intracellular","receptor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"11288","tokens":["In","contrast",",","the","RelA","(","p65",")","subunit","was","barely","detectable","in","monocytes",",","but","its","level","increased","markedly","in","MDMs","."],"ner_tags":[0,0,0,0,9,10,10,10,10,0,0,0,0,7,0,0,0,0,0,0,0,7,0]}
{"id":"11393","tokens":["All","such","events","were","abrogated","by","treatment","with","LY294002",",","a","specific","inhibitor","of","PI3-kinase","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"15778","tokens":["All","of","this","evidence","indicates","that","the","transcription","factor","BSAP","may","not","only","play","an","important","role","in","B-cell","differentiation","but","also","in","neural","development","and","spermatogenesis","."],"ner_tags":[0,0,0,0,0,0,0,9,10,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"516","tokens":["Type","II","major","histocompatibility","complex","combined","immune","deficiency","(","type","II","MHC","CID","or","bare","lymphocyte","syndrome",")","is","a","congenital","immunodeficiency","disease","characterized","by","absent","MHC","class","II","expression","."],"ner_tags":[9,10,10,10,10,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0]}
{"id":"776","tokens":["The","class","II","major","histocompatibility","complex","gene","HLA-DRA","is","expressed","in","B","cells",",","activated","T","lymphocytes",",","and","in","antigen-presenting","cells","."],"ner_tags":[0,1,2,2,2,2,2,1,0,0,0,7,8,0,0,7,8,0,0,0,7,8,0]}
{"id":"10010","tokens":["Northern","blot","analysis","of","SR-BP","gene","expression","revealed","a","single","transcript","of","2","kilobases","which","was","widely","expressed","among","organs",",","with","the","highest","abundance","in","liver","and","the","lowest","abundance","in","brain","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5474","tokens":["Moreover",",","gp120","induces","tyrosine","phosphorylation","of","signal","transducer","and","activator","of","transcription","(","STAT-1","alpha",")","as","well","as","the","Janus","kinase","(","JAK2",")","in","glial","cells","."],"ner_tags":[0,0,9,0,0,0,0,9,10,10,10,10,10,0,9,10,0,0,0,0,0,9,10,0,9,0,0,7,8,0]}
{"id":"5099","tokens":["Paradoxically",",","APL","cells","express","PML-RAR",",","an","aberrant","form","of","the","retinoic","acid","receptor","type","alpha","(","RAR","alpha",")","derived","from","the","leukemia-specific","t","(","15",";","17",")","chromosomal","translocation","."],"ner_tags":[0,0,5,6,0,9,0,0,0,0,0,0,9,10,10,10,10,0,9,10,0,0,0,0,1,2,2,2,2,2,2,2,2,0]}
{"id":"586","tokens":["Synchronous","recognition","of","peptides","158-176","and","248-263","is","important","for","the","development","of","GD",",","and","the","loss","of","recognition","of","one","of","these","epitopes","may","be","an","early","sign","of","immune","remission","and","a","predictor","of","euthyroidism","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18097","tokens":["Our","results","suggest","that","NF-M","plays","an","important","role","in","commitment","along","the","eosinophil","lineage","and","in","the","induction","of","apoptosis","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"5293","tokens":["This","is","the","first","report","of","an","ex","vivo","down-regulation","for","the","glucocorticoid","receptor","mRNA","expression",",","following","corticosteroid","treatment","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,3,0,0,0,0,0,0]}
{"id":"2473","tokens":["We","have","detected","activatable","PLD","in","Jurkat","cells",",","and","we","have","found","that","addition","of","phosphatidic","acid","(","PA",")",",","the","physiologic","product","of","PLD","action","on","phospholipids",",","is","rapidly","incorporated","into","Jurkat","cells","and","leads","to","activation","of","transcription","factor","AP-1","."],"ner_tags":[0,0,0,0,9,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,9,10,10,0]}
{"id":"16659","tokens":["PATIENTS",":","Sixteen","anorexic","patients",",","aged","16-27","years",",","with","a","mean","+\/-","SEM","body","mass","index","of","14.2","+\/-","2.0","(","ranging","from","11.1","to","17.4",")",",","and","15","normal","women","were","studied","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9456","tokens":["Electrophoretic","mobility","shift","assays","show","that","the","nucleoprotein","complex","formed","on","the","upstream","site","(","NF","kappa","B1",")","contains","the","classical","p50\/p65","heterodimer","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,1,2,0,9,10,10,0,0,0,9,10,10,0]}
{"id":"3452","tokens":["We","report","that","a","constitutively","active","form","of","calcineurin","partially","substitutes","for","the","Ca2+","co-stimulus","required","to","activate","the","IL-2","promoter","elements","IL-2A","(","which","binds","the","factors","OAP","and","Oct-1",")","and","IL-2E","(","which","binds","NF-AT",")",",","and","completely","substitutes","for","the","Ca2+","co-stimulus","required","to","stimulate","an","NF-kappa","B","-dependent","element","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,1,2,2,1,0,0,0,0,0,9,0,9,0,0,1,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0]}
{"id":"13189","tokens":["TCRzeta","and","p56","(","lck",")","were","detected","in","the","peripheral","blood","T","cells","in","27","of","29","patients",",","and","overall",",","reduced","levels","were","noted","visually","in","12","of","29","(","41","%",")","and","13","of","29","(","45","%",")","individuals",",","respectively","."],"ner_tags":[9,0,9,10,10,10,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7414","tokens":["The","immunogenetic","basis","of","severe","infections","caused","by","bacille","Calmette-Guerin","vaccine","and","environmental","mycobacteria","in","humans","remains","largely","unknown","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6698","tokens":["Transcriptional","control","of","the","IL-5","gene","by","human","helper","T","cells",":","IL-5","synthesis","is","regulated","independently","from","IL-2","or","IL-4","synthesis","."],"ner_tags":[0,0,0,0,9,0,0,7,8,8,8,0,9,0,0,0,0,0,9,0,9,0,0]}
{"id":"6315","tokens":["BLPs","were","found","to","induce","apoptosis","in","THP-1","monocytic","cells","through","human","Toll-like","receptor-2","(","hTLR2",")","."],"ner_tags":[9,0,0,0,0,0,0,5,6,6,0,9,10,10,10,10,10,0]}
{"id":"12487","tokens":["Previously","we","demonstrated","that","heterologous","activation","domains","can","fully","substitute","for","the","ZEBRA","activation","domain","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,0,9,10,10,0]}
{"id":"8036","tokens":["Unique","functions","and","disease","associations","have","been","postulated","for","such","trans-dimers",",","which","may","be","different","from","cis-encoded","DQ","molecules","encoded","by","the","corresponding","haplotypes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0]}
{"id":"9928","tokens":["To","further","elucidate","the","role","of","RelB","in","DC","differentiation",",","mRNA",",","intracellular","protein","expression",",","and","DNA","binding","activity","of","RelB","were","examined","in","immature","and","differentiated","human","DC",",","as","well","as","other","PB","mononuclear","cell","populations","."],"ner_tags":[0,0,0,0,0,0,9,0,7,0,0,3,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,7,8,0,0,0,0,0,7,8,8,8,0]}
{"id":"980","tokens":["PEBP2","alpha","B","is","the","murine","counterpart","of","human","AML1",",","which","is","located","at","the","breakpoints","of","the","8",";","21","and","3",";","21","chromosome","translocations","associated","with","acute","myeloid","leukemia","."],"ner_tags":[9,10,10,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,0]}
{"id":"1996","tokens":["The","host","response","to","Mycobacterium","tuberculosis","includes","granuloma","formation","at","sites","of","infection","and","systemic","symptoms","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12152","tokens":["The","molecular","mechanisms","by","which","IL-4","induces","expression","of","the","IL-4","gene","are","not","known",",","although","the","IL-4-activated","transcription","factor","signal","transducer","and","activator","of","transcription","6","(","Stat6",")","is","required","for","this","effect","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,1,2,0,0,0,0,0,0,9,10,10,10,10,10,10,10,10,10,0,9,0,0,0,0,0,0,0]}
{"id":"6392","tokens":["The","endogenous","levels","of","the","signalsome","components","were","unaffected","by","stimulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14838","tokens":["The","lytic","transition","of","Epstein-Barr","virus","is","imitated","by","recombinant","B-cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"4451","tokens":["NAC","not","only","blocks","the","effect","of","TPCK","but","enhances","mitogenesis","and","cytokine","production","(",">","2.5-fold","in","some","cases",")","upon","activation","of","unsuppressed","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"3380","tokens":["Once","in","the","nucleus",",","NF-ATc","interacts","with","NF-ATn","to","form","an","active","transcriptional","complex","."],"ner_tags":[0,0,0,0,0,9,0,0,9,0,0,0,9,10,10,0]}
{"id":"15170","tokens":["In","six","cases","we","determined","MR",",","plasma","aldosterone",",","and","SPD","in","patients","with","preeclampsia","before","and","3","months","after","delivery","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15205","tokens":["That","the","c-myb","oncogene","product","can","interact","synergistically","with","an","EBV-encoded","member","of","the","leucine","zipper","protein","family","suggests","c-myb","is","likely","to","engage","in","similar","interactions","with","cellularly","encoded","transcription","factors","."],"ner_tags":[0,0,9,10,10,0,0,0,0,0,9,10,0,0,9,10,10,10,0,1,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"13879","tokens":["The","only","exception","was","hydrogen","peroxide","at","20","microM",",","which","did","not","induce","catalase","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"4139","tokens":["There","is","general","agreement","on","the","inflammatory","pathogenesis","of","bronchial","asthma",":","an","accumulation","of","activated","eosinophils",",","degranulated","mast","cells",",","T","lymphocytes","and","in","very","severe","forms",",","granulocytes","has","constantly","been","found","in","the","bronchial","mucosa","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,8,8,0,7,8,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0]}
{"id":"8831","tokens":["Analysis","of","X-chromosome","inactivation","patterns","can","be","used","to","determine","whether","proliferative","disorders","are","clonal","in","origin","."],"ner_tags":[0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7757","tokens":["LPS","stimulation","selectively","activated","p38alpha","."],"ner_tags":[0,0,0,0,9,0]}
{"id":"18160","tokens":["Significantly",",","CsA","completely","suppressed","the","induction","of","NFAT","in","endothelial","cells","and","inhibited","the","activity","of","granulocyte-macrophage","colony-stimulating","factor","(","GM-CSF",")","gene","regulatory","elements","that","use","NFAT","by","60","%","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,7,8,0,0,0,0,0,1,2,2,2,2,2,2,2,2,0,0,9,0,0,0,0]}
{"id":"14212","tokens":["Within","this","DNA","fragment",",","there","were","two","novel","9-bp","motifs","(","-90\/-82","and","-40\/-32",")","with","high","homology","to","the","nuclear","factor-IL6","(","NF-IL6",")","binding","site","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,0]}
{"id":"12927","tokens":["Using","deletion","mutants","and","specific","CD4","promoter","mutants",",","we","identified","an","ATF\/CRE","binding","site","located","at","nucleotides","-67","to","-60","upstream","of","the","CD4","gene","transcription","start","site","that","is","important","for","HHV-6","transactivation","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,1,2,2,0,0,1,2,2,2,2,0,0,1,2,2,2,2,0,0,0,0,0,0,0]}
{"id":"5082","tokens":["As","assessed","with","mutagenized","promoters",",","the","most","important","IL-2","cis-regulatory","elements","in","normal","T","cells","are","the","proximal","AP-1","site","and","the","NF-","kappaB","site","."],"ner_tags":[0,0,0,1,2,0,0,0,0,1,2,2,0,7,8,8,0,0,1,2,2,0,0,1,2,2,0]}
{"id":"16122","tokens":["More","strikingly",",","the","80-kDa","protein","was","downregulated","in","a","dose-dependent","fashion","by","1",",","25","(","OH",")","2D3",";","this","effect","was","independent","of","the","mode","of","lymphocyte","activation","and","specific","for","the","1",",","25","(","OH",")","2D3","metabolite","of","vitamin","D3","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11749","tokens":["Associated","with","its","inhibitor",",","I","kappaB",",","NF-kappaB","resides","as","an","inactive","form","in","the","cytoplasm","."],"ner_tags":[0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"3523","tokens":["It","remains","to","be","shown","which","molecular","events","lead","to","the","specific","'pre-activation","'",",","i.e","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11405","tokens":["By","contrast",",","the","binding","activity","of","the","NF-kappa","(","B",")","and","EGR-1","transcription","factors","was","little","affected","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,0,9,9,10,0,0,0,0]}
{"id":"9834","tokens":["Blood","monocytes","from","patients","with","active","tuberculosis","are","activated","in","vivo",",","as","evidenced","by","an","increase","in","the","stimulated","release","of","proinflammatory","cytokines",",","such","as","TNF-alpha",",","and","the","spontaneous","expression","of","IL-2R","."],"ner_tags":[7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,0,0,0,0,0,0,9,0]}
{"id":"16789","tokens":["We","have","analyzed","the","functional","domains","of","the","minimal","Thy-1","promoter","and","show","that","the","dominant","promoter","elements","consist","of","multiple","binding","sites","for","the","transcription","factor","Sp1",",","an","inverted","CCAAT","box",",","and","sequences","proximal","to","the","transcription","start","site","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,1,2,2,0,0,1,2,2,0,0,9,10,9,0,0,0,1,2,0,0,0,0,0,0,1,2,2,0]}
{"id":"5231","tokens":["However",",","the","growth","of","most","mutated","viruses","was","suppressed","in","primary","rhesus","monkey","alveolar","macrophages","(","SIVmacMER","approximately","2xNFkappaB","approximately","substNFkappaB",">","deltaNFkappaB",">","deltaNFkappaB","deltaSpl234","approximately","deltaNFkappaBdeltaSpl",">","deltaSpl234","approximately","substSpl2",">","substSp23","approximately","substSp34","approximately","substSpl234",">","or","=","SIVmac239",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,0,0,0,9,0,9,0,9,0,9,9,0,9,0,9,0,9,0,9,0,9,0,9,0,0,0,0,0,0]}
{"id":"15509","tokens":["In","lymphoid","cell","lines",",","the","octamer","site","is","occupied","and","required","for","maximal","expression","."],"ner_tags":[0,5,6,6,0,0,1,2,0,0,0,0,0,0,0,0]}
{"id":"6584","tokens":["The","shorter","C-terminal","peptide","of","isoform","NF-ATc\/B","exerts","a","suppressive","transcriptional","effect","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"3861","tokens":["Primary","Sjogren","'s","syndrome","(","SS",")","is","an","autoimmune","rheumatic","disease","characterized","by","T","cell","hypoactivity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2490","tokens":["All","six","B-cell","lines","tested","showed","NF-kappa","B","activation","in","response","to","LMP1","expression",",","and","this","was","followed","in","five","of","six","lines","by","expression","of","ICAM-1","and","Bcl-2","."],"ner_tags":[0,0,5,6,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"15641","tokens":["This","phase","can","occur","to","some","extent","outside","of","the","thymus","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13385","tokens":["Work","reported","over","the","past","year","has","provided","insights","into","the","mechanisms","whereby","ligand","activation","of","the","nuclear","receptor","peroxisome","proliferator-activated","receptor","gamma","(","PPARgamma",")","regulates","systemic","glucose","and","lipid","homeostasis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,9,0,0,0,0,0,0,0,0]}
{"id":"8816","tokens":["The","function","of","SSB","T","cells","in","controls","remains","to","be","defined","."],"ner_tags":[0,0,0,5,6,6,0,0,0,0,0,0,0]}
{"id":"11863","tokens":["We","have","used","a","somatic","cell","hybridization","approach","to","genetically","analyse","regulation","of","the","activity","of","the","IgH","3","'","enhancer","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"2813","tokens":["In","the","present","study",",","we","showed","that","CD14+","adherent","human","monocytes","can","differentiate","into","CD1+relB+","dendritic","cells","(","DC",")","by","the","combination","of","GM-CSF","plus","interleukin-4","(","IL-4",")","and","that","they","differentiate","into","tartrate-resistant","acid","phosphatase","(","TRAP",")","-positive","osteoclast-like","multinucleated","giant","cells","(","MGC",")","by","the","combination","of","M-CSF","plus","IL-4","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,7,8,8,0,7,0,0,0,0,0,9,0,9,0,9,0,0,0,0,0,0,7,8,8,8,8,8,8,8,8,8,8,0,7,0,0,0,0,0,9,0,9,0]}
{"id":"18075","tokens":["We","have","determined","the","functional","role","of","C\/EBP","proteins","and","C\/EBP","sites","in","regulating","transcription","from","the","HIV-","1","LTR","in","monocytes\/macrophages","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,1,2,0,0,0,0,0,1,2,2,0,7,0]}
{"id":"7264","tokens":["The","data","indicate","that","oncogenes","activate","the","cytotoxicity","of","NK","cell","granules","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0]}
{"id":"2606","tokens":["Lymphocytes","of","non-pregnant","women",",","women","with","threatened","pre-term","delivery",",","and","men","showed","equivalent","levels",":","3","+\/-","1",",","3","+\/-","2","and","5","+\/-","4","fmol\/mg","respectively","."],"ner_tags":[7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17911","tokens":["The","production","and","characterization","of","Jurkat","cell","lines","that","constitutively","express","functional","human","immune","deficiency","virus","type","1","(","HIV-1",")","tat","protein",",","using","a","BK","virus","plasmid","expression","vector","and","HIV-1","tat","cDNA",",","is","described","."],"ner_tags":[0,0,0,0,0,5,6,6,0,0,0,0,9,10,10,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0]}
{"id":"5102","tokens":["By","contrast",",","AM580","is","not","effective","as","ATRA","in","modulating","the","expression","of","these","differentiation","markers","in","the","HL-60","cell","line","and","in","freshly","isolated","granulocytes","obtained","from","the","peripheral","blood","of","chronic","myelogenous","leukemia","patients","during","the","stable","phase","of","the","disease","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,5,6,6,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16007","tokens":["Inhibition","of","PKC","by","the","isoquinoline","derivative","H7","abolishes","induction","of","M-CSF","by","M-CSF","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"4382","tokens":["Thus",",","stress","may","cause","a","selective","suppression","of","TH1","functions","and","a","shift","toward","a","TH2","cytokine","pattern","rather","than","generalized","TH","suppression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"4369","tokens":["Up-regulation","of","RAR","(","alpha",")","and","PML-RAR","gene","expression","by","IFN","(","alpha",")","is","accompanied","by","a","strong","potentiation","in","the","induction","of","2","retinoid-dependent","granulocytic","markers",",","i.e.",",","granulocyte-colony-stimulating","factor","receptor","mRNA","and","leukocyte","alkaline","phosphatase","."],"ner_tags":[0,0,9,10,10,10,0,9,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,3,4,4,4,0,9,10,10,0]}
{"id":"11487","tokens":["5'-Rapid","amplification","of","cDNA","ends","(","5'-RACE",")","analysis","showed","that","transcription","initiation","occurred","at","several","closely","spaced","nearby","sites","originating","approximately","204","bp","upstream","from","the","translation","start","site","."],"ner_tags":[0,0,0,1,2,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0]}
{"id":"5980","tokens":["Affinity-driven","peptide","selection","of","an","NFAT","inhibitor","more","selective","than","cyclosporin","A","[","see","comments","]"],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16947","tokens":["Progressive","expression","of","cell","surface","maturation-specific","antigens","of","the","monocyte\/macrophage","lineage","was","induced","by","treatment","of","RWLeu-4","cells","with","VD3","for","24","to","72","h","at","doses","that","inhibited","cellular","proliferation","."],"ner_tags":[0,0,0,9,10,10,10,0,0,7,8,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3395","tokens":["These","data","identify","LDL","as","a","VCAM","-inducer","possibly","distinct","from","cytokines","and","endotoxin","."],"ner_tags":[0,0,0,9,0,0,9,0,0,0,0,9,0,9,0]}
{"id":"13500","tokens":["This","transactivation","sequence","is","altered","by","tissue-specific","alternative","splicing","in","newly","isolated","NFATx","isoforms",",","resulting","in","lower","transactivation","activity","in","Jurkat","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"7086","tokens":["The","frequency","of","FGF-1","-responsive","T","cells","is","increased","in","the","peripheral","blood","of","these","disorders",",","and","a","high","percentage","of","infiltrating","T","cells","in","rheumatoid","arthritis","synovium","express","receptors","for","FGF-1","."],"ner_tags":[0,0,0,9,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,9,0]}
{"id":"1707","tokens":["The","protease","inhibitors","N","alpha-tosylphenylalanyl","chloromethyl","ketone","(","TPCK",")","and","N","alpha-tosyl-L-lysine","chloromethyl","ketone","(","TLCK",")","block","activation","of","NF-kappa","B\/Rel","proteins","by","preventing","degradation","of","I","kappa","B","alpha","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,9,10,10,10,0]}
{"id":"16572","tokens":["In","contrast",",","mild","oxidation","with","glucose","oxidase","selectively","inhibits","p75","and","p85","binding","while","not","blocking","p50","and","p55","interactions","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,9,0,9,0,0,0,0,9,0,9,0,0]}
{"id":"5615","tokens":["Forced","expression","of","SOCS-1","in","a","macrophage","cell","line",",","RAW264",",","markedly","suppressed","trans-activation","of","an","IL-4-inducible","reporter","as","well","as","IL-6-","and","IFN-gamma-induced","reporter","gene","activity","."],"ner_tags":[0,0,0,1,0,0,5,6,6,0,5,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"17148","tokens":["A","study","was","made","of","adrenocortical","function","by","measuring","blood","plasma","cortisol","concentration","and","amount","of","glucocorticoid","receptors","in","lymphocytes","as","well","as","thyroid","function","by","measuring","blood","plasma","triidothyronine","and","thyroxine","concentration","in","58","bronchial","asthma","children","aged","1","to","14","years","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3550","tokens":["However",",","anti-","CD45","antibodies","inhibit","these","effects","in","cells","from","infected","individuals","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"4585","tokens":["We","demonstrate","here",",","however",",","that","NFAT","can","be","activated",",","and","significant","levels","of","IL-2","can","be","produced","by","the","CsA-resistant","CD28","-signaling","pathway","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,0]}
{"id":"4592","tokens":["We","compared","the","effects","of","the","deactivating","cytokine","interleukin","10","(","IL-10",")","on","human","peripheral","blood","mononuclear","cell","(","PBMC",")","responses","to","lipopolysaccharide","(","LPS",")",",","Cryptococcus","neoformans",",","and","Candida","albicans","."],"ner_tags":[0,0,0,0,0,0,9,10,9,10,0,9,0,0,7,8,8,8,8,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17110","tokens":["We","show","that","both","CREB","isoforms","are","expressed","in","many","cell","types","and","mammalian","species","."],"ner_tags":[0,0,0,0,9,10,0,0,0,7,8,8,0,0,0,0]}
{"id":"17269","tokens":["This","expression","pattern","can","not","be","accounted","for","by","cell-cycle","position","or","heritable","variation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7631","tokens":["Secretion","of","ILs","was","blocked","with","monensine","."],"ner_tags":[0,0,9,0,0,0,0,0]}
{"id":"17649","tokens":["BSAP",":","a","key","regulator","of","B-cell","development","and","differentiation","."],"ner_tags":[9,0,0,0,0,0,7,0,0,0,0]}
{"id":"15232","tokens":["In","contrast",",","no","effect","on","the","levels","of","the","octamer","binding","proteins",",","Oct-1","or","Oct-2",",","were","found","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,9,0,0,0,0]}
{"id":"5147","tokens":["The","role","of","p16","in","the","E2F-dependent","thymidine","kinase","regulation","."],"ner_tags":[0,0,0,9,0,0,9,10,10,0,0]}
{"id":"8537","tokens":["Binding","of","c-Rel","to","the","Fc","gammaR1","STAT","site","also","occurs","in","human","peripheral","blood","T","cells","immortalized","with","HTLV-I","in","vitro","and","is","correlated","with","enhanced","levels","of","proliferation","of","these","cells","."],"ner_tags":[0,0,9,0,0,1,2,2,2,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3293","tokens":["Comparison","of","cDNA","and","genomic","sequences","reveals","a","4-exon","structure","characteristic","of","the","FOS","family","of","genes","."],"ner_tags":[0,0,1,0,0,0,0,0,1,2,0,0,0,1,2,2,2,0]}
{"id":"1967","tokens":["The","level","of","mRNA","expression","of","the","NM23","gene","is","significantly","lower","in","cell","lines","that","derive","from","more","infiltrating","primary","melanomas","than","in","cell","lines","obtained","from","less","infiltrating","tumours","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0]}
{"id":"17399","tokens":["The","complementary","DNAs","are","the","products","of","distinct","genes",",","yet","both","ITF-1","and","ITF-2","are","structurally","and","functionally","similar","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0]}
{"id":"16296","tokens":["The","predicted","amino","acid","sequence","of","this","protein","contains","features","characteristic","of","transcriptional","activators","as","well","as","transcriptional","repressors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,0]}
{"id":"10301","tokens":["Interestingly",",","we","find","that","in","contrast","to","SLP-76",",","overexpression","of","SLAP-130","diminishes","T","cell","antigen","receptor","-induced","activation","of","the","interleukin-2","promoter","in","Jurkat","T","cells","and","interferes","with","the","augmentation","of","interleukin-2","promoter","activity","seen","when","SLP-76","is","overexpressed","in","these","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,9,0,9,10,10,10,0,0,0,0,1,2,0,5,6,6,0,0,0,0,0,0,1,2,0,0,0,9,0,0,0,0,0,0]}
{"id":"8166","tokens":["In","this","study",",","we","examined","the","involvement","of","the","Jak\/Stat","pathway","in","the","signaling","of","eosinophils","after","IFN-gammaR","conjugation","by","the","ligand","binding","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,0,9,0,0,0,0,0,0]}
{"id":"5022","tokens":["The","gammac","chain","is","a","subunit","of","multiple","cytokine","receptors","(","interleukin","(","IL",")","-2",",","IL-4",",","IL-7",",","IL-9",",","and","IL-15",")",",","the","expression","of","which","is","restricted","to","hematopoietic","lineages","."],"ner_tags":[0,9,10,0,0,0,0,0,9,10,0,9,10,10,10,10,0,9,0,9,0,9,0,0,9,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"14955","tokens":["We","present","evidence","that","induction","of","neutrophil","binding","by","LPS","is","actually","suppressed","by","agents","that","elevated","cAMP","levels","."],"ner_tags":[0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18293","tokens":["We","used","mononuclear","cell","priming","cultures","and","inflammatory","synovial","fluids","(","SFs",")","derived","from","arthritis","patients","to","examine","the","regulation","of","cytokine","production","and","STAT","activity","by","an","inflammatory","synovial","microenvironment","."],"ner_tags":[0,0,5,6,6,6,0,7,8,8,0,7,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0]}
{"id":"9579","tokens":["The","glucocorticoid","receptor","was","shown","to","repress","activity","of","both","the","RelA","homodimer","and","the","NF-kappa","B1\/RelA","heterodimer","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,9,10,0,0,9,10,10,0]}
{"id":"4196","tokens":["Inhibition","of","T","lymphocyte","activation","by","cAMP","is","associated","with","down-regulation","of","two","parallel","mitogen-activated","protein","kinase","pathways",",","the","extracellular","signal-related","kinase","and","c-Jun","N-terminal","kinase","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,0,9,10,10,0]}
{"id":"17577","tokens":["Thus",",","c-Fos\/c-Jun","heterodimers","might","contribute","to","the","repression","of","DRA","gene","expression","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,1,2,0,0]}
{"id":"11265","tokens":["Gel","electrophoretic","mobility","shift","assay","detected","an","induced","DNA-binding","activity","in","these","cells","in","response","to","LPS","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9097","tokens":["We","identified","a","cell-type-specific","differential","response",":","CREB",",","CTF",",","OTF-1",",","OFT-2",",","and","NF-kappa","B","genes","were","strongly","induced","1","to","4","hours","after","influenza","A","virus","infection","in","the","monocytic","cell","line","Mono","Mac","6",",","while","in","freshly","prepared","human","monocytes","no","significant","changes","were","detected","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,5,6,6,0,0,0,0,0,0,7,0,0,0,0,0,0]}
{"id":"16218","tokens":["PMA","induction","increases","the","level","of","a","number","of","specific","binding","complexes","relative","to","the","resting","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,7,8,0]}
{"id":"14059","tokens":["Minimal","residual","disease","in","acute","myelogenous","leukemia","with","PML\/RAR","alpha","or","AML1\/ETO","mRNA","and","phenotypic","analysis","of","possible","T","and","natural","killer","cells","in","bone","marrow","."],"ner_tags":[0,0,0,0,0,0,0,0,3,4,4,4,4,0,0,0,0,7,8,8,8,8,8,0,0,0,0]}
{"id":"16791","tokens":["Our","results","show","that","the","structure","of","this","promoter","only","permits","productive","interactions","of","the","two","transcription","factors","Sp1","and","CP1","with","the","basal","transcription","machinery","in","the","presence","of","enhancer","sequences","."],"ner_tags":[0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,9,10,9,0,9,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"16302","tokens":["G0S2","mRNA","increases","transiently","within","1-2","hr","of","the","addition","of","lectin","or","cycloheximide","to","cultured","blood","mononuclear","cells","."],"ner_tags":[3,4,0,0,0,0,0,0,0,0,0,9,0,0,0,7,8,8,8,0]}
{"id":"13740","tokens":["Expression","of","gamma-interferon","inducible","protein","10","(","IP-10",")",",","a","STAT1alpha-responsive","gene","and","mediator","of","inflammatory","response",",","was","also","abnormally","expressed","in","the","monocytes","from","II-2","."],"ner_tags":[0,0,9,10,10,10,0,9,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,7,0,5,0]}
{"id":"10003","tokens":["A","nuclear","membrane","protein","related","to","yeast","sterol","isomerase","."],"ner_tags":[0,9,10,10,0,0,9,10,10,0]}
{"id":"11508","tokens":["Mutations","which","abrogated","the","gene-suppressive","activity","of","NRE","gamma","prevented","RFX1","from","binding","to","NRE","gamma","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,9,0,0,0,1,2,0]}
{"id":"10731","tokens":["We","found","that","the","membrane","proximal","proline-rich","domain","and","adjacent","16","residues","are","essential","for","both","hGM-CSF","-dependent","cell","proliferation","and","differentiation","."],"ner_tags":[0,0,0,0,9,10,10,10,0,9,10,10,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"450","tokens":["We","examined","mRNA","levels","of","various","V-ATPase","subunits","during","differentiation","of","both","native","monocytes","and","the","cell","line","THP-1",",","and","found","that","transcriptional","and","post-transcriptional","mechanisms","could","account","for","increases","in","cell","V-ATPase","content","."],"ner_tags":[0,0,3,0,0,0,9,0,0,0,0,0,7,8,0,0,5,6,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"14050","tokens":["A","1.2","kb","FasL","promoter","responded","to","DNA","damage",",","as","well","as","coexpression","with","p65","Rel","or","Fos\/Jun","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0]}
{"id":"13110","tokens":["As","several","inflammatory","cytokines","and","oxidative","stresses","are","involved","in","the","pathogenesis","of","HIV-1","infection",",","we","investigated","the","inhibitory","effects","of","cepharanthine","on","tumor","necrosis","factor","alpha","(","TNF-alpha",")","-","and","phorbol","12-myristate","13-acetate","(","PMA",")","-induced","HIV-1","replication","in","chronically","infected","cell","lines","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"8499","tokens":["The","B","cell-specific","cell","surface","molecule","CD19","is","expressed","at","all","stages","of","B","cell","development",",","including","normal","plasma","cells",",","and","mediates","signal","transduction","via","interaction","with","cytoplasmic","effector","proteins","."],"ner_tags":[0,9,10,10,10,10,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"15796","tokens":["A","number","of","genes","known","to","be","induced","following","T","cell","activation","and","associated","with","cell","growth","were","increased","in","the","transfectants",",","including","c-fos",",","c-myc",",","c-myb",",","HLA-DR",",","lck",",","NF-kappa","B",",","interleukin-2","and","interleukin-2","receptor","alpha","(","IL-2R","alpha",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,0,1,0,1,0,1,0,1,0,1,0,9,10,0,1,0,1,2,2,0,1,2,0,0]}
{"id":"13723","tokens":["These","data","suggest","that","Rho","potentiates","AP-1","transcription","during","T-cell","activation"],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0]}
{"id":"5590","tokens":["This","review","suggests","roles","for","these","alterations","in","the","development","of","lymphoid","neoplasms","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17843","tokens":["We","have","used","immunolabeling",",","Western","blot","analysis",",","and","electrophoretic","mobility","shift","and","supershift","assays","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1282","tokens":["Their","mechanisms","of","action","are","multiple","and","complex","and","a","number","of","reports","describe","significant","systemic","effects","of","locally","administered","glucocorticoids","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16013","tokens":["Primary","structure","analysis","showed","that","the","encoded","protein","contains","three","tandem","zinc-finger","sequences","of","the","type","Cys2-Xaa12-His2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,9,0]}
{"id":"17197","tokens":["Mutation","of","the","TCF-1","alpha","binding","site","diminished","enhancer","activity","and","disrupted","the","synergism","observed","in","vivo","between","tandem","enhancer","repeats","."],"ner_tags":[0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"8248","tokens":["Copyright","1999","Academic","Press","."],"ner_tags":[0,0,0,0,0]}
{"id":"14368","tokens":["The","nuclear","factor","of","activated","T","cells","(","NF-AT",")","3","is","an","inducible","DNA-binding","protein","that","is","essential","for","transcriptional","induction","of","the","IL-2","gene","during","T","cell","activation","."],"ner_tags":[0,9,10,10,10,10,10,0,9,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0]}
{"id":"9896","tokens":["This","biochemical","defect","correlated","with","a","specific","block","to","Oct-2","gene","expression","at","the","level","of","transcription",",","whereas","the","expression","of","Oct-1","was","unaffected","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"11630","tokens":["Binding","of","viral","peptide","to","cell","lines","bearing","DQA1*0201",",","in","comparison","to","DQA1*0501",",","was","only","moderately","reduced","and","may","not","explain","this","effect","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3956","tokens":["No","glucocorticoid","recognition","sequences","are","present","in","this","promoter","region","and","dexamethasone","is","still","able","to","repress","transcription","when","the","multimerized","NF-kappa","B","sequence","is","transactivated","by","TNF-alpha","upon","transfection","in","293","cells","."],"ner_tags":[0,1,2,2,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,9,0,0,0,5,6,0]}
{"id":"1404","tokens":["We","have","demonstrated","that","the","monocyte-specific","expression","of","the","CSF-1","receptor","is","regulated","at","the","level","of","transcription","by","a","tissue-specific","promoter","whose","activity","is","stimulated","by","the","monocyte\/B-cell-specific","transcription","factor","PU.1","(","D.-E.Zhang",",","C.J.Hetherington",",","H.-M.Chen",",","and","D.G.Tenen",",","Mol.Cell.","Biol.14",":","373-381",",","1994",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,9,10,10,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3548","tokens":["Implications","for","replication","of","HIV-1","."],"ner_tags":[0,0,0,0,0,0]}
{"id":"5918","tokens":["In","the","synovial","tissue",",","fully","differentiated","perivascular","DC","are","found","in","close","association","with","T","cells","and","with","B","cell","follicles",",","sometimes","containing","follicular","DC","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,7,8,0,0,7,8,8,0,0,0,7,8,0]}
{"id":"2484","tokens":["An","ability","of","the","Epstein-Barr","virus","latent","membrane","protein","LMP1","to","enhance","the","survival","of","infected","B","cells","through","upregulation","of","the","bcl-2","oncogene","was","first","suggested","by","experiments","involving","gene","transfection","and","the","selection","of","stable","LMP1+","clones","(","S.Henderson",",","M.","Rowe",",","C.Gregory",",","F.Wang",",","E.Kieff",",","and","A.Rickinson",",","Cell","65",":","1107-1115",",","1991",")","."],"ner_tags":[0,0,0,0,9,10,10,10,10,9,0,0,0,0,0,7,8,8,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14164","tokens":["The","activated","form","of","NF-kappa","B",",","which","is","rapidly","taken","up","into","nuclei",",","initiates","transcription","from","immediate","early","genes","in","a","wide","variety","of","cell","types","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13805","tokens":["IL-2","binding","analysis","demonstrated","that","IL-2","markedly","increased","the","number","of","low","affinity","IL-2Rs","on","the","leukemia","cells",",","without","an","effect","on","the","number","of","high-affinity","IL-2Rs","."],"ner_tags":[9,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,7,8,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8972","tokens":["Functional","testosterone","receptors","in","plasma","membranes","of","T","cells","."],"ner_tags":[0,9,10,0,0,0,0,7,8,0]}
{"id":"17596","tokens":["Constitutive","expression","was","observed","in","a","small","population","of","cells","in","the","dermis","and","some","mice","have","developed","skin","lesions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5198","tokens":["The","developmental","stage-specificity","of","PYBF","and","the","location","of","its","binding","site","between","the","fetal","and","adult","beta-globin","(","HBB",")","-like","genes","suggest","that","PBYF","and","its","binding","site","may","function","in","fetal-to-adult","globin","gene","switching","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,0,0,9,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"6728","tokens":["To","determine","the","diversity","in","X-chromosome","methylation","patterns",",","which","reflect","Lyonization",",","assessed","by","the","HUMARA","assay","in","the","supposedly","normal","population",",","we","analyzed","granulocytes","and","T","cells","from","97","relatively","young","(","18-","to","35-year-old",")","healthy","female","volunteers","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,7,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16818","tokens":["This","was","compared","with","the","TREp","binding","of","reticulocyte","lysate-synthesized","TRs","."],"ner_tags":[0,0,0,0,0,1,0,0,9,10,10,0]}
{"id":"6915","tokens":["All","mAECA","possessed","high","activity","against","macrovascular","EC",",","but","none","had","significant","antimicrovascular","EC","activity","."],"ner_tags":[0,9,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0]}
{"id":"3315","tokens":["For","this","expression","pattern","the","first","280","bp","upstream","of","the","major","transcriptional","start","site","seems","to","be","sufficient","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,1,2,2,2,0,0,0,0,0]}
{"id":"18182","tokens":["Enhancement","of","HIV-1","replication","is","related","in","part","to","increased","DNA-binding","activity","of","cellular","transcription","factors","such","as","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,10,0]}
{"id":"14200","tokens":["Surprisingly",",","the","NF-kappa","B","and","HLP-1","binding","activities","were","substantially","inhibited","in","acyclovir-treated","cells","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"6085","tokens":["Flow","cytometric","cell","sorting","of","normal","bone","marrow","established","that","MNDA","is","initially","expressed","in","myeloid","blast","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,7,8,8,0]}
{"id":"5702","tokens":["Human","monocyte","IL-1","receptor","antagonist","(","IL-1ra",")","messenger","ribonucleic","acid","(","mRNA",")","expression","and","protein","secretion","are","inhibited","by","dexamethasone","."],"ner_tags":[3,4,4,4,4,4,4,4,4,4,4,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12330","tokens":["The","lung","macrophage","was","identified","as","the","main","cellular","source","for","critical","inflammatory","mediators","such","as","tumor","necrosis","factor-alpha",",","the","chemokines","interleukin","(","IL",")","-8","and","-6",",","and","matrix","metalloproteinase-9","in","this","model","system","of","mechanical","ventilation","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,10,0,0,9,9,10,10,10,10,10,10,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"7233","tokens":["This","review","focuses","on","studies","defining","recently","identified","crucial","signals","for","the","biogenesis","of","secondary","lymphoid","organs","and","for","the","maintenance","of","their","proper","microarchitecture","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3003","tokens":["The","CpG","dinucleotide","in","this","element","is","selectively","methylated","in","Th2","T","cells","and","other","cells","that","do","not","express","IFN-gamma",",","and","methylation","markedly","reduces","transcription","factor","binding","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,7,8,8,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,0,0]}
{"id":"6541","tokens":["Activation","of","the","Janus","kinase","3","-STAT5a","pathway","after","CD40","triggering","of","human","monocytes","but","not","of","resting","B","cells","."],"ner_tags":[0,0,0,9,10,10,9,0,0,9,0,0,7,8,0,0,0,7,8,8,0]}
{"id":"6533","tokens":["Thus","increased","expression","of","GCRbeta","could","account","for","glucocorticoid","insensitivity","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0]}
{"id":"12586","tokens":["This","assay","has","potential","as","a","screen","to","establish","the","immunogenicity","of","viral","antigens","in","vitro","using","T","cells","from","naive","donors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0]}
{"id":"135","tokens":["However",",","the","mechanism","(","s",")","by","which","priming","occurs","is","poorly","defined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18327","tokens":["The","observation","that","binding","sites","for","the","nuclear","factor-mu","negative","regulator","(","NF-muNR",")","enhancer","repressor","overlap","nuclear","matrix","attachment","regions","(","MARs",")","in","this","enhancer","has","lead","to","the","hypothesis","that","the","cell","type","specificity","of","the","enhancer","might","be","controlled","by","regulating","nuclear","matrix","attachment","(","Scheuermann",",","R.","H.",",","and","Chen",",","U.","(","1989",")","Genes","&","Dev.","3",",","1255-1266",")","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,10,10,10,10,10,10,0,9,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10113","tokens":["In","addition",",","BHRF1","protected","these","cells","from","monocyte-mediated","killing","but","failed","to","protect","them","from","killing","mediated","by","lymphokine-activated","killer","cells","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"13191","tokens":["In","patients","treated","with","IL-2\/","IFN","alpha","-based","therapy",",","relative","levels","of","TCRzeta","increased","significantly","(","P","=","0.002",")","on","day","15","of","cycle","one","compared","with","the","baseline","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5367","tokens":["In","vivo",",","anergy","has","mainly","been","studied","at","the","cellular","level","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13347","tokens":["Consistent","with","the","diagnosis","of","PEL",",","both","CRO-AP\/3","and","CRO-AP\/5","expressed","indeterminate","(","i.e.","non-B",",","non-T",")","phenotypes","although","immunogenotypic","studies","documented","their","B-cell","origin","."],"ner_tags":[0,0,0,0,0,5,0,0,5,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"8847","tokens":["The","5","'","sequences","up","to","nucleotide","-120","of","the","human","and","murine","IL-16","genes","share",">","84","%","sequence","homology","and","harbor","promoter","elements","for","constitutive","and","inducible","transcription","in","T","cells","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,7,8,0]}
{"id":"532","tokens":["Erythroid","lineage","and","developmental","stage","specificities","."],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"7600","tokens":["Interestingly",",","CyA","and","indomethacin","did","not","suppress","tumor","necrosis","factor-alpha","(","TNF-alpha",")","-induced","adhesion","molecule","expression","on","HUVECs",",","whereas","aspirin","had","an","inhibitory","effect","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0]}
{"id":"232","tokens":["Nuclear","run-on","assays",",","transfection","studies","using","various","VCAM-1","promoter","reporter","gene","constructs",",","and","electrophoretic","mobility","shift","assays","indicated","that","NO","represses","VCAM-1","gene","transcription",",","in","part",",","by","inhibiting","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"9110","tokens":["Recent","studies","show","that","human","osteoclasts","develop","in","vitro","from","hematopoietic","cells",";","however",",","special","cultures","conditions","and\/or","cytokine","mobilized","peripheral","blood","are","apparently","required","."],"ner_tags":[0,0,0,0,7,8,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10004","tokens":["SR","31747A",",","defined","as","a","sigma","ligand",",","is","a","novel","immunosuppressive","agent","that","blocks","proliferation","of","human","and","mouse","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"443","tokens":["Both","compounds","inhibited","the","mixed","lymphocyte","reaction",",","and","this","inhibition","was","reversed","by","exogenous","IL-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"8941","tokens":["Therefore",",","our","data","not","only","reveal","that","Nmi","can","potentiate","STAT","-dependent","transcription",",","but","also","suggest","that","it","can","augment","coactivator","protein","recruitment","to","at","least","some","members","of","a","group","of","sequence-specific","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"7174","tokens":["Control","of","cell","cycle","entry","and","apoptosis","in","B","lymphocytes","infected","by","Epstein-Barr","virus","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,0,0,0,0,0]}
{"id":"1137","tokens":["Even","a","moderate","increase","in","the","cellular","cysteine","supply","elevates","the","intracellular","glutathione","(","GSH",")","and","glutathione","disulfide","(","GSSG",")","levels","and","potentiates","immunological","functions","of","lymphocytes","in","vitro","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0]}
{"id":"13361","tokens":["Upon","cell","activation",",","displacement","of","the","autoinhibitory","domain","by","calmodulin","binding","allows","NFAT","to","bind","additionally","to","the","calcineurin","active","site",",","thus","positioning","NFAT","for","immediate","dephosphorylation","at","functional","phosphoserine","residues","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,0,0,9,0,0,0,0,0,9,10,10,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"5976","tokens":["Transcription","factors",",","such","as","NF","kappa","B","and","AP-1",",","are","activated","upon","stimulation","of","the","cells","with","several","chemoattractants","at","physiologically","relevant","concentrations","."],"ner_tags":[9,10,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17010","tokens":["The","majority","of","the","positive","cases","occurred","in","female","cases","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1183","tokens":["In","contrast",",","this","receptor","mutant","showed","low","levels","of","xenobiotic","response","element-binding","activity",",","indicating","that","the","PAS","domain","may","be","important","for","DNA-binding","affinity","and\/or","specificity","of","the","receptor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11724","tokens":["One","means","of","understanding","the","role","of","p38","in","these","responses","is","to","identify","proteins","with","functions","regulated","by","p38","-catalysed","phosphorylation","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"7208","tokens":["Here","we","report","SOCS-3","expression","in","response","to","IL-2","in","both","T-cell","lines","and","human","peripheral","blood","lymphocytes","."],"ner_tags":[0,0,0,9,0,0,0,0,9,0,0,5,6,0,7,8,8,8,0]}
{"id":"16387","tokens":["Glucocorticoid","receptors","in","normal","leukocytes",":","effects","of","age",",","gender",",","season",",","and","plasma","cortisol","concentrations","."],"ner_tags":[9,10,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1564","tokens":["Collectively",",","(","a",")","transcriptional","factor","(","s",")","necessary","for","expression","of","ICAM-I","gene","may","be","repressed","in","MT-I","through","DNA","methylation","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,1,2,0,0,0,0,5,0,0,0,0]}
{"id":"10902","tokens":["Early","B","cell","factor","(","EBF",")","and","E47","participate","in","the","transcriptional","control","of","early","B","lymphocyte","differentiation","."],"ner_tags":[9,10,10,10,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18316","tokens":["Increased","labeling","of","these","proteins","occurred","to","similar","extents","in","control","cells","and","in","cells","that","had","been","infected","with","L.","donovani","for","16","h","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8444","tokens":["The","concentrations","required","for","50","%","displacement","of","17beta-","(","3H",")","estradiol","(","CB50",")","were",":","17beta-estradiol",",","1.34","nmol\/L",";","diethylstilbestrol",",","1.46","nmol\/L",";","daidzein",",","1.6","micromol\/L",";","DG",",","14.7","micromol\/L",";","genistein",",","0.154","micromol\/L",";","GG",",","7.27","micromol\/L","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15647","tokens":["The","loss","of","conventional","responsiveness","is","probably","caused","by","alterations","at","the","level","of","signaling",",","and","may","be","a","manifestation","of","the","physiological","state","that","is","a","precondition","for","selection","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1041","tokens":["These","long","term","cultures","are","referred","to","as","M-TAT\/EPO",",","M-TAT\/GM-CSF",",","and","M-TAT\/SCF","cells",",","respectively","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,0,0,0]}
{"id":"9079","tokens":["Inhibition","of","IL-1RI","and","IL-1RII","mRNA","levels","by","IFN-gamma","was","transcriptionally","mediated",",","and","correlated","directly","with","decreased","production","of","soluble","IL-1RII","."],"ner_tags":[0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"11455","tokens":["The","Jak1",",","Jak2",",","Jak3",",","and","Fes","tyrosine","kinases","have","been","demonstrated","to","undergo","tyrosine","phosphorylation","in","response","to","interleukin","(","IL",")","-4","stimulation","in","different","cell","systems","."],"ner_tags":[0,9,10,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0]}
{"id":"4533","tokens":["Tissue-specific","expression","of","interleukin-3","(","IL-3",")","is","mediated","via","cis-acting","elements","located","within","315","base","pairs","of","the","transcription","start","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,1,2,0,0,0,0,0,0,0,1,2,0]}
{"id":"493","tokens":["To","explore","the","modifications","of","not","reproductive","target","tissues","as","ovulation","markers","we","studied","the","behaviour","of","Albuminemia",",","Platelet","Factor","IV","(","as","indicator","of","Platelet","Aggregation",")",",","Type","II","estrogenic","receptors","in","42","ovulation","induced","women",",","undergoing","our","observation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"5680","tokens":["Administration","of","megakaryocyte","growth","and","development","factor","or","interleukin","6","could","not","overcome","the","differentiation","block","."],"ner_tags":[0,0,9,10,10,10,10,0,9,10,0,0,0,0,0,0,0]}
{"id":"13413","tokens":["We","have","previously","shown","that","the","presence","of","the","CD4","cytoplasmic","tail","is","critical","for","human","immunodeficiency","virus","(","HIV",")","-induced","apoptosis","(","J.Corbeil",",","M.Tremblay",",","and","D.D.Richman",",","J.Exp.Med.183",":","39-48",",","1996",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13908","tokens":["The","role","of","E-proteins","in","B-","and","T-lymphocyte","development","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0]}
{"id":"2721","tokens":["We","report","here","that","PML","is","expressed","at","low","levels","or","not","expressed","in","normal","circulating","human","monocytes",",","lymphocytes",",","and","polymorphonucleate","cells",",","but","is","markedly","induced","by","interferon",";","that","PML","and","PML\/RAR","alpha","expression","is","augmented","by","interferon","in","the","NB4","APL","cell","line",",","which","carries","the","t","(","15",";","17",")",",","and","in","APL","blasts","from","patients",";","that","interferon","inhibits","growth","and","survival","of","NB4","APL","cells","in","cooperation","with","RA",";","that","interferons","alone","have","minimal","maturation","effect","on","NB4","cells",";","and",",","finally",",","that","interferon","gamma",",","but","not","alpha","or","beta",",","induces","maturation","and","growth","suppression","of","NB4","cells","with","de","novo","retinoid","resistance",",","and","partially","restores","RA","response","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,0,0,7,8,0,0,0,0,0,0,9,0,0,9,0,9,10,0,0,0,0,9,0,0,5,6,6,6,0,0,0,0,1,2,2,2,2,2,0,0,0,7,8,0,0,0,0,9,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12689","tokens":["Moreover",",","we","demonstrate","a","novel","role","for","GATA-3","in","directly","repressing","Th1","development","distinct","from","its","positive","actions","on","Th2-specific","cytokines","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"17325","tokens":["Activation","of","human","CD4","T","lymphocytes","."],"ner_tags":[0,0,5,6,6,6,0]}
{"id":"837","tokens":["They","also","provided","support","for","the","hypothesis","that","CBF","is","a","factor","in","T","lymphocytes","that","is","responsible","for","recognition","of","the","SL3","cores","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,7,8,0,0,0,0,0,0,0,1,2,0]}
{"id":"7835","tokens":["Although","BCL-6","(","-",")","\/syn-1","(","+",")","RS","cells","of","HIV-HD","express","CD40",",","they","are","not","surrounded","by","CD40","ligand-positive","(","CD40L+",")","reactive","T","lymphocytes",",","which",",","in","HD","of","the","general","population",",","are","thought","to","regulate","the","disease","phenotype","through","CD40","\/CD40L","interactions","."],"ner_tags":[0,9,0,0,0,0,0,0,0,5,6,0,0,0,9,0,0,0,0,0,0,7,8,8,8,8,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,9,0,0]}
{"id":"296","tokens":["OBJECTIVE",":","Activation","of","the","hypothalamic-pituitary-adrenal","axis","is","of","vital","importance","during","critical","illness","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16769","tokens":["The","other","gene",",","designated","Rhom-3",",","is","not","on","chromosome","11","but","also","retains","homology","to","the","LIM","domain","of","rhombotin","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,1,0]}
{"id":"13161","tokens":["The","characterization","of","CIITA","mutants","that","are","able","to","discriminate","between","promoters","with","or","without","the","W","box","strongly","suggests","that","CIITA","requires","such","interactions","for","function","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,9,0,0,0,0,0,0]}
{"id":"14607","tokens":["Our","results","suggest","that","while","transfection","analyses","offer","an","adequate","approximation","of","the","effects","of","the","LS","mutations",",","the","analysis","of","viral","replication","using","a","mutant","viral","stock","presents","a","more","accurate","picture",",","which","is","sometimes","at","variance","with","the","transfection","results","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17985","tokens":["Promoter","function","of","the","5","'","flanking","region","of","the","thromboxane","receptor","gene","was","evaluated","by","transfection","of","thromboxane","receptor","gene","promoter\/chloramphenicol","acetyltransferase","(","CAT",")","chimera","plasmids","into","platelet-like","K562","cells","."],"ner_tags":[0,0,0,0,1,2,2,2,0,0,1,2,2,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,0,0,5,6,0]}
{"id":"657","tokens":["Substitution","promoters","were","then","generated","where","the","entire","X-box",",","or","only","the","X1-","or","X2-boxes","of","HLA-DRA","were","replaced","with","the","analogous","regions","of","HLA-DQB","."],"ner_tags":[0,0,0,0,0,0,0,0,1,0,0,0,0,1,2,2,0,1,0,0,0,0,0,0,0,1,0]}
{"id":"8556","tokens":["The","results","argue","against","a","loss-of-function","signaling","defect","as","the","sole","basis","for","clonal","anergy","induction","and","document","the","presence","of","a","dominant-acting","repressor","molecule","that","inhibits","signal","transduction","to","the","IL-2","gene","within","viable","anergic","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,1,2,0,0,7,8,8,0]}
{"id":"10790","tokens":["Inhibition","of","human","immunodeficiency","virus","type","1","replication","in","vitro","by","a","novel","combination","of","anti-Tat","single-chain","intrabodies","and","NF-kappa","B","antagonists","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"1635","tokens":["DRA","promoter","occupancy","in","other","class","II-negative","B","cell","lines",",","derived","from","patients","with","bare","lymphocyte","syndrome",",","is","drastically","different","from","the","one","observed","in","RJ","2.2.5","and","Raji","cells","."],"ner_tags":[1,2,0,0,0,5,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,5,6,0]}
{"id":"12038","tokens":["Uncontrolled","replication","of","a","virus",",","which","is","harmful","to","the","host","is","also","disadvantageous","to","the","virus","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15142","tokens":["Although","activated","in","T","cell","leukemias",",","expression","of","SCL","and","LYL-1","is","low","or","undetectable","in","normal","T","cell","populations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,7,8,8,8,0]}
{"id":"12074","tokens":["Copyright","1998","Academic","Press","."],"ner_tags":[0,0,0,0,0]}
{"id":"14623","tokens":["Other","applications","involve","the","introduction","of","other","GATA-binding","protein","family","members","to","determine","whether","they","rescue","the","mutation","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0]}
{"id":"4260","tokens":["These","results","confirm","and","extend","the","notion","of","the","functional","conservation","of","the","AIR-1","gene","product","across","species","barriers","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0]}
{"id":"15364","tokens":["Surrogate","thyroglobulin","receptors","and","T","cell","proliferation","in","Hashimoto","'s","thyroiditis","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"15923","tokens":["This","difference","was","also","seen","at","the","mRNA","level","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"17248","tokens":["Neither","FKBP","binding","nor","inhibition","of","rotamase","activity","of","FKBP","alone","is","sufficient","to","explain","the","biologic","actions","of","these","drugs","."],"ner_tags":[0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13065","tokens":["Large","part","of","the","activated","genes","were","under","very","stringent","regulation","being","expressed","only","after","stimulation","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5362","tokens":["The","function","of","oriP","depends","on","a","trans-acting","factor","(","s",")","encoded","by","the","viral","genome","."],"ner_tags":[0,0,0,1,0,0,0,9,10,0,0,0,0,0,0,1,2,0]}
{"id":"2549","tokens":["These","findings","and","other","related","results","are","reviewed","here","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"3776","tokens":["Here","we","report","that","human","leukaemia","cells","carrying","the","translocation","t","(","17",";","19",")","rapidly","died","by","apoptosis","when","programmed","to","express","a","dominant-negative","suppressor","of","the","fusion","protein","E2A-HLF",",","indicating","that","the","chimaeric","oncoprotein","probably","affects","cell","survival","rather","than","cell","growth","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"2233","tokens":["One","63-kDa","isoform",",","termed","I","kappa","B","gamma-1",",","which","lacks","59","amino","acids","C-terminal","to","ankyrin","repeat","7",",","has","a","novel","35-amino","acid","C","terminus","encoded","by","an","alternative","reading","frame","of","the","p105","gene","."],"ner_tags":[0,9,10,0,0,9,10,10,10,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,9,10,10,10,0,0,0,1,2,2,0,0,1,2,0]}
{"id":"10121","tokens":["Its","expression","is","stimulus-","and","cell-specific","."],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"2245","tokens":["The","promoter","sequence","analysis","of","these","two","genes","revealed","that","they","are","embedded","within","a","CpG","island","and","share","structural","features","often","found","in","the","promoters","of","housekeeping","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,0,1,2,0]}
{"id":"1861","tokens":["Animals","were","sacrificed","at","various","times","post-dosing","until","120","h",",","spleen","was","excised","and",",","after","incubation","of","lymphocytes","with","PHA",",","splenocyte","blastogenic","responses","were","assessed","by","measuring","cellular","incorporation","of","3H-thymidine","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7104","tokens":["Previously","we","reported","that","3-deazaadenosine","(","DZA",")",",","a","potent","inhibitor","and","substrate","for","S-adenosylhomocysteine","hydrolase","inhibits","bacterial","lipopolysaccharide-induced","transcription","of","tumor","necrosis","factor-alpha","and","interleukin-1beta","in","mouse","macrophage","RAW","264.7","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,10,0,9,0,5,6,6,6,6,0]}
{"id":"2792","tokens":["Pancreatic","development","and","maturation","of","the","islet","B","cell","."],"ner_tags":[0,0,0,0,0,0,7,8,8,0]}
{"id":"187","tokens":["When","either","serine-32","or","serine-36","of","I","kappa","B-alpha","was","mutated",",","the","protein","did","not","undergo","signal-induced","phosphorylation","or","degradation",",","and","NF-kappa","B","could","not","be","activated","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"9920","tokens":["In","vitro","transcription","assays","showed","that","Tax","was","able","to","significantly","increase","the","transcriptional","activity","of","a","template","containing","the","-257","to","+74","region","of","the","c-sis\/PDGF-B","promoter","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,1,2,0]}
{"id":"6513","tokens":["NFAT","transcription","factors","bind","to","a","sequence","in","the","IL-2","enhancer","known","as","the","antigen","receptor","response","element","2","(","ARRE-2",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,2,2,2,0,1,0,0]}
{"id":"17789","tokens":["Monocytes","convert","25","(","OH",")","D3","to","1",",","25","(","OH",")","2D3","and","to","24-hydroxylated","metabolites","more","polar","than","1",",","25","(","OH",")","2D3","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14379","tokens":["One","of","these","activities","was","found","to","be","a","novel",",","less","abundant",",","Rb-","E2F","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"11450","tokens":["In","the","tumor","samples",",","expression","of","LAZ3\/BCL6","was","observed","in","68","%","of","all","B","cell","NHL","and","none","of","the","non-B","lymphomas","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2831","tokens":["The","monoclonal","antibody","(","mAb",")","J393","induces","apoptosis","in","Jurkat","T-cells","."],"ner_tags":[0,9,10,0,9,0,9,0,0,0,5,6,0]}
{"id":"11817","tokens":["We","also","show","that","calcineurin","associated","with","the","N-terminal","domain","of","NFATx1","at","multiple","docking","sites","and","caused","a","reduction","of","size",",","indicative","of","dephosphorylation",",","in","NFATx1","."],"ner_tags":[0,0,0,0,9,0,0,0,9,10,0,9,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"16926","tokens":["The","infection","of","a","variety","of","cultured","and","primary","lymphoid","cells","with","a","recombinant","retrovirus","containing","a","histone","promoter-driven","beta-galactosidase","gene","is","shown","to","result","in","the","expression","of","beta-galactosidase","in","50","%","to","100","%","of","the","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"5591","tokens":["Damage","to","the","genes","encoding","proteins","that","function","in","intracellular","signaling",",","transcription",",","or","regulation","of","the","cell","cycle","has","been","identified","and","linked","at","varying","degrees","to","the","progression","of","certain","lymphoid","malignancies","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12237","tokens":["The","host","mechanisms","regulated","by","such","permissivity","factors","are","potential","targets","for","anti-HIV-1","therapy","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14613","tokens":["We","have","established","the","essential","nature","of","GATA-1","during","both","primitive","and","definitive","erythropoiesis","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"18267","tokens":["CONCLUSIONS",":","Sexual","hormones",",","through","their","receptors",",","may","influence","the","activity","of","eosinophils","in","patients","with","VKC","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,7,0,0,0,0,0]}
{"id":"430","tokens":["Danazol","decreases","transcription","of","estrogen","receptor","gene","in","human","monocytes","."],"ner_tags":[0,0,0,0,1,2,2,0,7,8,0]}
{"id":"16487","tokens":["The","mature","mitochondrial","forms","of","the","erythroid","and","housekeeping","ALAS","isozymes","are","predicted","to","have","molecular","weights","of","59.5","kd","and","64.6","kd",",","respectively","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10311","tokens":["The","coordinated","production","of","all","blood","cells","from","a","common","stem","cell","is","a","highly","regulated","process","involving","successive","stages","of","commitment","and","differentiation","."],"ner_tags":[0,0,0,0,0,7,8,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16347","tokens":["NAC","may","be","considered","for","the","treatment","of","HIV-1-infected","individuals","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4156","tokens":["In","contrast",",","engagement","of","the","TCR","by","class","II","MHC\/superantigen",",","either","with","or","without","CD28","ligation",",","resulted","in","the","induction","of","NF-AT",",","AP-1",",","and","NF-kappaB","as","well","as","IL-2","production","."],"ner_tags":[0,0,0,0,0,0,9,0,9,10,10,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0,9,0,0,9,0,0,0,9,0,0]}
{"id":"3191","tokens":["Although","JAK3","is","required","for","proper","lymphoid","development",",","the","precise","roles","of","this","kinase","in","IL-2","and","IL-4","signaling","in","lymphocytes","have","not","been","defined","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,7,0,0,0,0,0]}
{"id":"4955","tokens":["Human","T-cell","leukemia","virus","type","I","(","HTLV-I",")","-infected","T-cell","lines","constitutively","produce","high","levels","of","interleukin-1alpha","(","IL-1alpha",")","."],"ner_tags":[5,6,6,6,6,6,6,6,6,6,6,6,0,0,0,0,0,9,0,9,0,0]}
{"id":"6379","tokens":["Necrosis","was","excluded","by","propidium","iodide","staining","."],"ner_tags":[0,0,0,0,0,0,0,0]}
{"id":"8695","tokens":["In","humans",",","alternative","splicing","of","the","GR","precursor","mRNA","gives","rise","to","two","receptor","isoforms",",","termed","GRalpha","and","GRbeta","."],"ner_tags":[0,0,0,0,0,0,0,3,4,4,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"3597","tokens":["In","this","paper","we","have","investigated","the","role","of","Egr-1","in","B","cell","growth","regulation","by","examining","the","gene","expression","in","a","panel","of","B","cell","lines",",","including","both","EBV","genome","negative","and","EBV","carrying","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,1,2,0,0,5,6,6,6,0]}
{"id":"10","tokens":["Consistent","with","these","differences",",","we","have","previously","demonstrated","that","the","enhancer\/promoter","region","of","HIV-2","functions","quite","differently","from","that","of","HIV-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"12942","tokens":["Human","T","cell","leukemia","virus-I","(","HTLV-I",")","Tax","-mediated","apoptosis","in","activated","T","cells","requires","an","enhanced","intracellular","prooxidant","state","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,7,8,8,0,0,0,0,0,0,0]}
{"id":"16327","tokens":["Monitoring","DPD","activity","may","be","important","in","the","management","of","patients","experiencing","severe","toxicity","secondary","to","FUra","chemotherapy","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17882","tokens":["Reconstitution","of","a","cell-free","system","and","identification","of","the","ubiquitin-carrier","protein",",","E2",",","and","a","novel","ubiquitin-protein","ligase",",","E3",",","involved","in","conjugation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,9,10,0,9,0,0,0,0,0]}
{"id":"16397","tokens":["One","is","the","21-base-pair","(","bp",")","core","element","that","is","responsible","for","trans-activation","by","the","HTLV-I","trans-activator","p40tax","and","that","has","the","ability","to","bind","to","cyclic-AMP","responsive","element","binding","factor","(","CREB",")","-like","factor","(","s",")","."],"ner_tags":[0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,9,9,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,10,10,0,0,0,0]}
{"id":"18387","tokens":["RNase","treatment","prior","to","hybridization","considerably","reduces","the","size","of","this","signals","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15052","tokens":["Specific","mRNAs","for","c-fos","and","c-jun","were","detectable","within","30","min","after","cell","activation","and","reached","maximal","levels","within","2","h","."],"ner_tags":[0,3,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2113","tokens":["Mitogen","induction","of","the","electrophoretic","mobility","shift","assay","complexes","is","not","accounted","for","by","protein","phosphorylation","or","by","induction","of","CREB","."],"ner_tags":[0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"10603","tokens":["Surfactant","protein","A","activates","NF-kappa","B","in","the","THP-1","monocytic","cell","line","."],"ner_tags":[9,10,10,0,9,10,0,0,5,6,6,6,0]}
{"id":"1538","tokens":["C\/EBP","beta","activated","the","TNF","alpha","gene","promoter","in","cotransfection","assays","and","bound","to","it","at","a","site","which","failed","to","bind","the","closely","related","protein","C\/EBP","alpha","."],"ner_tags":[9,10,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"1590","tokens":["IL-1","receptor","and","TCR","signals","synergize","to","activate","NF-kappa","B","-mediated","gene","transcription","."],"ner_tags":[9,10,0,9,0,0,0,0,9,10,0,0,0,0]}
{"id":"3099","tokens":["TRAF1",",","TRAF2",",","and","TRAF3","bind","to","a","single","site","in","the","LMP1","CT","corresponding","to","amino","acids","(","aa",")","199","to","214",",","within","a","domain","which","is","important","for","B-lymphocyte","growth","transformation","(","aa","187","to","231",")","."],"ner_tags":[9,0,9,0,0,9,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11157","tokens":["The","aim","of","this","study","was","to","delineate","the","molecular","mechanisms","involved","in","this","potentiation","process","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17412","tokens":["However",",","cyclosporin","A","and","FK506","did","not","inhibit","Ca2+","mobilization","dependent","expression","of","c-fos","mRNA","indicating","that","only","a","subset","of","signalling","pathways","regulated","by","Ca2+","is","sensitive","to","these","drugs","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2853","tokens":["By","assaying","CAT","enzyme","activity","across","a","24-h","PRL","induction","time","course",",","we","were","able","to","assign","G1","vs.","S","phase","PRL","responses","of","the","IRF-1","gene","to","different","regions","of","the","IRF-1","5'-flanking","and","promoter","DNA","."],"ner_tags":[0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,1,2,0,0,0,0,0,9,1,0,1,2,0]}
{"id":"787","tokens":["In","EBV-positive","cases","of","Hodgkin","'s","disease",",","the","EBERs",",","EBNA1",",","and","the","LMPs","are","expressed","(","latency","II",")",",","whereas","in","Burkitt","'s","lymphoma","(","BL",")","only","the","EBERs","and","EBNA1","have","been","detected","(","latency","I",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,3,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,9,0,0,0,0,0,0,0,0]}
{"id":"11236","tokens":["Notably",",","no","activation","of","Jak1",",","Jak2",",","Tyk2",",","Stat1",",","or","Stat3","was","observed","in","neutrophils","following","G-CSF","stimulation","."],"ner_tags":[0,0,0,0,0,9,0,9,0,9,0,9,0,0,9,0,0,0,7,0,9,0,0]}
{"id":"15157","tokens":["Glucocorticoid","receptor","concentrations","in","mononuclear","leukocytes","(","MNL",")","in","these","patients","were","comparable","with","those","in","both","other","patients","with","SLE","and","healthy","persons","."],"ner_tags":[9,10,0,0,7,8,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2553","tokens":["A","500-bp","fragment","encompassing","this","hypersensitive","site","(","nt","4481","to","4982",")","exhibited","transcription-enhancing","activity","(","two-","to","threefold",")","when","it","was","cloned","in","its","natural","position","with","respect","to","the","HIV-1","promoter","after","transient","transfection","in","U937","and","CEM","cells","."],"ner_tags":[0,1,2,0,0,1,2,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,5,0,5,6,0]}
{"id":"13095","tokens":["This","correlated","with","a","strong","reduction","of","BrdU","incorporation","after","24","h","of","TNFalpha","treatment","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"16349","tokens":["The","human","T","cell-specific","transcription","factor","TCF-1","alpha","plays","a","key","role","in","the","tissue-specific","activation","of","the","T","cell","receptor","(","TCR",")","C","alpha","enhancer","and","binds","to","pyrimidine-rich","elements","(","5'-PyCTTTG-3","'",")","present","in","a","variety","of","other","T","cell-specific","control","regions","."],"ner_tags":[0,9,10,10,10,10,9,10,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"8279","tokens":["In","the","present","report",",","we","identified","and","monitored","the","pocket","protein-E2F","complexes","in","human","primary","B-lymphocytes","after","activation","by","phorbol","12-myristate","13-acetate","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,7,8,8,0,0,0,0,0,0,0]}
{"id":"329","tokens":["The","mRNA","for","the","Duffy","blood","group","antigen",",","the","erythrocyte","receptor","for","the","Plasmodium","vivax","malaria","parasite",",","has","recently","been","cloned","and","shown","to","encode","a","widely","expressed","chemokine","receptor","."],"ner_tags":[0,3,0,0,9,10,10,10,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"7210","tokens":["Unlike","CIS",",","SOCS-3","was","rapidly","tyrosine","phosphorylated","in","response","to","IL-2","."],"ner_tags":[0,9,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"11171","tokens":["Electrophoretic","mobility","shift","(","EMS",")","analyses","utilizing","oligonucleotides","homologous","to","each","of","the","21","bp","repeat","elements","reacted","with","nuclear","extracts","derived","from","cell","lines","of","lymphocytic",",","monocytic",",","neuronal",",","and","glial","cell","origin","have","demonstrated","differential","binding","of","cellular","factors","to","the","three","21","bp","repeats","(","1-4",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,5,6,0,7,8,8,8,8,8,8,8,8,8,0,0,0,0,0,9,10,0,0,0,1,2,2,0,0,0,0]}
{"id":"4652","tokens":["A","gel","retardation","experiment","with","synthetic","double-stranded","oligonucleotides","showed","that","activated","NF-kappa","B","consisting","of","p50\/p65","heterodimer","bound","to","all","four","putative","NF-kappa","B","DNA","probes",",","suggesting","that","all","four","putative","NF-kappa","B","recognition","sites","play","an","important","role","in","inducible","TNF-alpha","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,9,0,0]}
{"id":"9867","tokens":["The","same","gene","segment","was","not","transcribed","in","IL-5-nonproducing","T","cell","clones",",","suggesting","that","human","T","cell","IL-5","synthesis","is","regulated","at","the","transcriptional","level","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"5014","tokens":["To","develop","a","transformation","system","with","a","conditional","Epstein-Barr","virus","nuclear","antigen","2","(","EBNA2",")","gene",",","we","fused","the","hormone","binding","domain","of","the","oestrogen","receptor","to","the","N","or","C","terminus","of","EBNA2","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,9,10,10,0,0,0,0,0,0,9,10,10,10,0,9,0]}
{"id":"15507","tokens":["Using","in","vivo","genomic","footprinting","we","identified","interactions","in","B-cell","lines","at","the","octamer","site","and","the","Y",",","X1",",","and","X2","boxes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,0,0,1,2,0,0,1,2,2,2,2,2,2,0]}
{"id":"6944","tokens":["Similar","to","the","N","terminal","transactivation","domain","of","c-Jun",",","TAD-A","is","inducibly","phosphorylated",",","but","this","phosphorylation","is","dispensable","for","the","interaction","with","CBP\/p300","."],"ner_tags":[0,0,0,9,10,10,10,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"2605","tokens":["The","ZR-75-1","cell","line","showed","an","expression","of","642","fmol\/mg","whereas","lymphocytes","of","pregnant","women","showed","an","expression","<","or","=","4","fmol\/mg","."],"ner_tags":[0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6499","tokens":["Constructs","were","stably","transfected","into","murine","erythroleukemia","cells","and","promoter","chromatin","structure","and","gene","expression","were","analyzed","."],"ner_tags":[0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"14966","tokens":["Infection","with","the","human","immunodeficiency","virus","(","HIV",")","has","been","shown","to","induce","production","of","several","cytokines","both","in","vitro","and","in","vivo","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"11280","tokens":["CONCLUSION",":","Cytomegalovirus","immediate","early","gene","products","significantly","enhanced","expression","of","IL-6","in","LPS-stimulated","cells","."],"ner_tags":[0,0,9,10,10,10,10,0,0,0,0,9,0,0,0,0]}
{"id":"2607","tokens":["These","results","show","that","there","is","no","evidence","of","specific","expression","of","the","progesterone","receptor","in","pregnancy","and","exclude","any","prognostic","character","in","spontaneous","abortion","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16633","tokens":["Another","component","of","the","AP-1","transcription","complex",",","JunB",",","is","shown","to","inhibit","activation","mediated","by","JunD","."],"ner_tags":[0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,9,0]}
{"id":"224","tokens":["In","HTLV-I-infected","cord","blood","lymphocytes",",","the","transition","from","IL-2","-dependent","to","IL-2","-independent","growth","correlated","with","the","acquisition","of","a","constitutively","activated","Jak","-STAT","pathway",",","which","suggests","that","this","pathway","participates","in","HTLV-I-mediated","T","cell","transformation","."],"ner_tags":[0,5,6,6,6,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,9,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2111","tokens":["Binding","of","the","four","complexes","to","CRE","is","prevented","by","dephosphorylation","of","nuclear","extracts","and","is","restored","by","rephosphorylation","with","cAMP-dependent","protein","kinase","or","endogenous","kinases","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,0]}
{"id":"15172","tokens":["Aldosterone","levels","returned","to","normal","nonpregnant","values","after","delivery","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"7543","tokens":["Involvement","of","NF-kappaB","p50\/p65","heterodimer","in","activation","of","the","human","pro-interleukin-1beta","gene","at","two","subregions","of","the","upstream","enhancer","element","."],"ner_tags":[0,0,9,10,10,0,0,0,0,1,2,2,0,0,0,0,0,1,2,2,0]}
{"id":"2128","tokens":["Our","results","point","to","a","novel","alternative","mechanism","of","action","of","alpha-tcp","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15731","tokens":["In","addition",",","they","respond","to","LPS","and","cytokines","with","activation","and","expression","of","inflammatory","effector","gene","products","similar","to","those","elicited","by","the","antigen","driven","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"1597","tokens":["These","results","suggest","that","IL-1","induces","both","NF-kappa","B","nuclear","translocation","and","the","synthesis","of","a","protein","(","s",")","responsible","for","terminating","NF-kappa","B","-DNA","interaction","in","the","nucleus","."],"ner_tags":[0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"12216","tokens":["In","order","to","shed","light","on","the","early","events","of","the","EBV","infection","of","T","cells",",","we","have","used","in","situ","reverse","transcription","based","polymerase","chain","reaction","(","RT-PCR",")","to","study","the","initial","EBV","transcriptional","program","in","homogeneous","CD4+","and","CD8+","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,0]}
{"id":"11062","tokens":["Unlike","full-sized","NOTCH1",",","two","such","truncated","forms","of","the","protein","either","lacking","a","major","portion","of","the","extracellular","domain","(","DeltaE",")","or","consisting","only","of","the","intracellular","domain","(","ICN",")","were","found","to","activate","transcription","in","cultured","cells",",","presumably","through","RBP-Jkappa","response","elements","within","DNA","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"14407","tokens":["In","contrast",",","CAT","gene","expression","directed","by","a","multimer","of","the","OCT-1","proximal","(","OCT-1p",")","-binding","site","was","equivalent","in","patient","and","controls","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,1,2,2,2,2,2,2,0,0,0,0,0,0,0]}
{"id":"13476","tokens":["Coupling","of","the","upstream","beta","globin","sequence","from","approximately","-500","to","-250","bp","to","the","truncated","delta","promoter","fragment","led","to","complete","extinction","of","transcription","activity",",","consistent","with","a","negative","regulatory","effect","of","the","beta","globin","gene","upstream","element","(","s",")","."],"ner_tags":[0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0]}
{"id":"18127","tokens":["Human","TR","beta","1","mRNA","levels","in","lymphocytes","were","1.8","+\/-","0.4",",","1.9","+\/-","0.5",",","1.1","+\/-","0.4","10","(","-18",")","mol\/microgram","RNA","in","hypo-",",","eu","-and","hyperthyroid","patients",",","respectively",",","corresponding","to","an","estimated","0.5","-2","molecules","per","cell","."],"ner_tags":[3,4,4,4,4,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4829","tokens":["In","the","present","study",",","we","demonstrate","that","signal-mediated","induction","of","p105","processing","in","human","T","cells","is","associated","with","de","novo","synthesis","of","this","precursor","protein","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,8,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"7793","tokens":["We","examined","chemokine","gene","expression","following","the","differentiation","of","a","monocyte",",","macrophage","cell","lineage","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,7,0,5,6,6,0]}
{"id":"18345","tokens":["Furthermore",",","we","demonstrate","that","the","PU-SF","complex","binds","to","PU.1","sites","found","on","a","number","of","myeloid","promoters",",","and","its","formation","requires","an","intact","PU.1","site","adjacent","to","a","single-stranded","region","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,9,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0]}
{"id":"1666","tokens":["Benzene","toxicity","towards","lymphocytes","is","thought","to","be","mediated","by","metabolites","of","benzene","including","benzoquinone","(","BQ",")","."],"ner_tags":[0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"684","tokens":["Hence",",","it","has","been","proposed","that","ectopic","expression","of","TAL1","promotes","the","development","of","T-ALL","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"2474","tokens":["Treatment","of","Jurkat","cells","with","anti-CD3","mAb","activated","both","PLD","and","transcription","factor","AP-1","."],"ner_tags":[0,0,5,6,0,9,10,0,0,9,0,9,10,10,0]}
{"id":"12540","tokens":["NF-X2",",","which","contains","members","of","the","AP-1\/ATF\/CREB","families","of","transcription","factors",",","interacts","with","the","X2","box","(","5'-TGCGTCA-3","'",")","from","positions","-97","to","-91","in","the","DRA","promoter","."],"ner_tags":[1,0,0,0,0,0,0,9,10,0,9,10,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"12370","tokens":["The","structural","organization","of","the","393","amino","acid","long","human","TRAMP","is","most","homologous","to","TNF","receptor","1","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,9,10,10,0]}
{"id":"9937","tokens":["The","CAML","(","calcium-modulator","and","cyclophilin","ligand",")","protein","is","a","coinducer","of","NF-AT","activation","when","overexpressed","in","Jurkat","T","cells","."],"ner_tags":[0,9,10,10,10,10,10,10,10,0,0,0,0,9,0,0,0,0,5,6,6,0]}
{"id":"3566","tokens":["Mobility","shift","assays","showed","that","the","CLE0","sequence","has","an","AP1-binding","site","and","is","associated","with","an","NF-AT-like","factor",",","termed","NF-CLE0","gamma","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,1,2,0,0,0,0,0,9,10,0,0,9,10,0]}
{"id":"8781","tokens":["Twenty-seven","patients","with","tumors","of","the","oral","cavity",",","oropharynx",",","and","maxillary","sinus","were","examined",",","all","of","which","were","confirmed","as","squamous","cell","carcinomas","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18134","tokens":["Multiple","proteins","interact","with","the","nuclear","inhibitory","protein","repressor","element","in","the","human","interleukin-3","promoter","."],"ner_tags":[0,0,0,0,0,1,2,2,2,2,0,0,1,2,2,0]}
{"id":"6262","tokens":["The","mechanism","of","activation","was","analyzed","by","using","anti-TNF-alpha","antibody","and","various","inhibitors","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"9944","tokens":["Recent","work","from","several","laboratories","has","demonstrated","that","Rel\/NF-kappa","B","transcription","factors","regulate","apoptosis","in","many","cell","types","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,9,10,0,0,0,0,0,0,0]}
{"id":"948","tokens":["The","Epstein-Barr","virus","(","EBV",")","nuclear","antigen","2","(","EBNA-2",")","protein","is","essential","for","the","immortalization","of","human","primary","B","cells","by","EBV","."],"ner_tags":[0,9,10,10,10,10,10,10,10,0,9,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0]}
{"id":"11217","tokens":["In","addition",",","mutation","of","the","Y-box","element","alone","abrogated","Tax1","-mediated","activation","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,9,0,0,0]}
{"id":"5434","tokens":["These","results","suggest","that","LPS","activation","of","JNK","in","monocyte\/macrophage","cells","is","a","CD14-","and","protein","tyrosine","phosphorylation-dependent","event","that","may","mediate","the","early","activation","of","AP-1","in","regulating","LPS-triggered","gene","induction","."],"ner_tags":[0,0,0,0,0,0,0,9,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"10347","tokens":["The","balance","between","repression","by","ZEB","and","transcriptional","activation","by","c-Myb","\/Ets","provides","a","flexible","regulatory","mechanism","for","controlling","gene","expression","in","hematopoietic","cells","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,9,9,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"11572","tokens":["We","demonstrated","that","constitutive","expression","of","NF-kappaB","in","primary","human","monocytes","changed","significantly","with","differentiation","in","vitro","to","monocyte-derived","macrophages","(","MDMs",")","and","differentiation","in","vivo","to","alveolar","macrophages","(","AMs",")","."],"ner_tags":[0,0,0,0,0,0,9,0,7,8,8,0,0,0,0,0,0,0,7,8,0,7,0,0,0,0,0,0,7,8,0,7,0,0]}
{"id":"5525","tokens":["Erythrocyte","polyamines","levels","were","identical","between","cancer","patients","and","controls","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1232","tokens":["In","contrast","to","prior","in","vitro","studies",",","at","least","a","fraction","of","the","phosphorylated","form","of","I","kappa","B","alpha","remains","physically","associated","with","the","NF-kappa","B","complex","in","vivo","but","is","subject","to","rapid","degradation",",","thereby","promoting","the","nuclear","translocation","of","the","active","NF-kappa","B","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"13674","tokens":["Prior","to","in","vivo","IL-2","administration",",","the","typical","binding","pattern","of","transcription","factors","in","PBMC","from","patients","resembled","that","seen","in","fresh","PBMC","from","healthy","individuals","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,9,10,0,7,0,0,0,0,0,0,0,7,0,0,0,0]}
{"id":"4082","tokens":["The","results","suggest","that","a","combination","of","the","three","proximal","cis-acting","elements","may","constitute","a","minimal","region","responsible","for","CTL-specific","expression","of","perforin","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"394","tokens":["This","study","investigated","the","effect","of","TCDD","on","expression","of","the","CD19","gene","in","a","human","B","lymphocyte","cell","line","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,5,6,6,6,6,0]}
{"id":"716","tokens":["In","vitro","translated","Spi-B","protein","can","bind","to","PU.1","binding","sites","in","myeloid","promoters","and","transactivate","these","promoters","in","nonmyeloid","cells","."],"ner_tags":[0,0,0,9,10,0,0,0,1,2,2,0,1,2,0,0,0,1,0,7,8,0]}
{"id":"13895","tokens":["A","recent","study","showed","a","MLL\/AF10","fusion","in","all","cases","of","AML","with","t","(","10",";","11",")","and","various","breakpoints","on","chromosome","11","ranging","from","q13","to","q23","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0,1,2,0,0,1,0,1,0]}
{"id":"9687","tokens":["Increased","CRH","promoter","activity","following","phorbol","ester","treatment","was","inhibited","by","a","dominant","negative","NF-IL6","mutant",",","showing","that","the","effects","of","phorbol","ester","were","principally","mediated","by","C\/EBP","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"9674","tokens":["Agonistic","activity","of","a","CD40-specific","single-chain","Fv","constructed","from","the","variable","regions","of","mAb","G28-5","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,9,10,0,9,10,0]}
{"id":"15677","tokens":["The","steroid","hormone","are","very","versatile","molecules",":","although","they","are","related","among","them","by","their","chemical","structure",",","they","have","very","diverse","functions","and","including","antagonic","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7658","tokens":["Copyright","1999","Academic","Press","."],"ner_tags":[0,0,0,0,0]}
{"id":"4319","tokens":["Neither","IL-10","nor","IL-4","inhibited","LPS-induced","NF-kappa","B","binding","activity","."],"ner_tags":[0,9,0,9,0,0,9,10,0,0,0]}
{"id":"18109","tokens":["ETS1","transactivates","the","human","GM-CSF","promoter","in","Jurkat","T","cells","stimulated","with","PMA","and","ionomycin","."],"ner_tags":[9,0,0,1,2,2,0,5,6,6,0,0,0,0,0,0]}
{"id":"9228","tokens":["One","transformation","effector","site","(","TES1",")",",","located","within","the","membrane","proximal","45","residues","of","the","cytoplasmic","tail",",","constitutively","engages","tumor","necrosis","factor","receptor-associated","factors","."],"ner_tags":[0,9,10,10,0,9,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"17305","tokens":["The","transactivator","(","IE-2",")","gene","of","the","human","cytomegalovirus","(","CMV",")","can","enhance","HIV-2","as","well","as","HIV-1","gene","expression","in","vitro","."],"ner_tags":[0,1,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13716","tokens":["The","small","GTP-binding","protein","Rho","potentiates","AP-1","transcription","in","T","cells","."],"ner_tags":[0,9,10,10,10,0,9,0,0,7,8,0]}
{"id":"7833","tokens":["In","this","study",",","we","have","applied","these","two","markers","to","the","study","of","HIV-HD","histogenesis","and","correlated","their","expression","status","to","the","virologic","features","of","this","disease","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17048","tokens":["In","a","series","of","functional","studies","we","found","that","modulation","of","the","level","of","the","mRNAs","coding","for","both","the","c-myc","oncogene","and","the","growth","factor","known","as","granulocyte-monocyte","colony","stimulating","activity","by","1",",","25","(","OH",")","2D3","correlated","with","the","1",",","25","(","OH",")","2D3","receptor","status","of","these","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0]}
{"id":"12690","tokens":["GATA-3","inhibits","Th1","cytokines","by","a","cell-intrinsic","mechanism","that","is","not","dependent","on","IL-4","and","that","may","involve","repression","of","IL-12","signaling","."],"ner_tags":[9,0,9,10,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0]}
{"id":"15185","tokens":["Enhanced","overall","enzyme","activity","was","found","in","nuclear","extracts","by","1","h","after","incubation","with","calcitriol","(","final","ethanol","concentration","0.0001","%","v\/v",")","in","HL60","and","PBL","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,7,0]}
{"id":"317","tokens":["In","contrast",",","integrin","ligation","with","antibodies","induces","tyrosine","phosphorylation","of","Syk","but","not","of","FAK","or","paxillin","."],"ner_tags":[0,0,0,9,0,0,9,0,0,0,0,9,0,0,0,9,0,9,0]}
{"id":"6557","tokens":["Novel","therapies","for","inflammatory","bowel","disease","."],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"13727","tokens":["To","evaluate","a","potential","mechanism","for","these","differences","in","function",",","we","evaluated","expression","of","protein","kinase","C","(","PKC",")","isoforms","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0]}
{"id":"9459","tokens":["The","NF","kappa","B2","effect","was","dependent","on","the","presence","of","the","STAT6","binding","site",",","demonstrating","that","the","NF","kappa","B2","motif","is","necessary","but","not","sufficient","for","mediating","cytokine","up-regulation","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,0,0]}
{"id":"16901","tokens":["Type-II","estrogen","binding","sites","in","a","lymphoblastoid","cell","line","and","growth-inhibitory","effect","of","estrogen",",","anti-estrogen","and","bioflavonoids","."],"ner_tags":[9,10,10,10,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0]}
{"id":"17703","tokens":["Using","a","polyclonal","antibody","to","murine","NFATp",",","Western","blot","analysis","of","various","mouse","tissues","demonstrated","that","the","110-130-kDa","NFATp","protein","was","highly","expressed","in","thymus","and","spleen","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"8195","tokens":["Although","peripheral","blood","T","cells","are","largely","unresponsive","to","these","cytokines","without","prior","activation",",","a","small","subset","of","CD8+","T","cells","(","CD8+CD18bright",")","is","strongly","activated","by","the","combination","of","IL-12","and","IL-2","."],"ner_tags":[0,0,0,7,8,0,0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,8,0,7,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"454","tokens":["Primer","extension","and","ribonuclease","protection","analyses","indicate","a","single","major","transcriptional","start","site","."],"ner_tags":[0,0,0,9,0,0,0,0,0,1,2,2,2,0]}
{"id":"18439","tokens":["The","main","activity","of","the","silencer","has","been","mapped","to","the","first","900","bp","of","5","'","flanking","DNA",",","which","contains","nine","binding","sites","for","a","nuclear","factor","present","in","non-","erythroid","cells","but","not","in","erythroid","cells","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,9,10,0,0,0,7,8,0,0,0,7,8,0]}
{"id":"2320","tokens":["These","results","identify","LIF","as","a","stimulus","of","HIV","replication","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0]}
{"id":"6225","tokens":["Analysis","of","cell","lines","Daudi","and","THP-1","that","differentially","express","gamma","(","c",")","and","IL-13R","alpha1","showed","that","IL-13","can","activate","STAT6","in","IL-13R","alpha1-positive","THP-1","cells","but","not","in","gamma","(","c",")","-positive",",","IL-13R","alpha1-negative","Daudi","cells","."],"ner_tags":[0,0,5,6,5,0,5,0,0,0,9,10,10,10,0,9,10,0,0,9,0,0,9,0,5,6,6,6,0,0,0,5,6,6,6,6,6,6,6,6,6,0]}
{"id":"8458","tokens":["NF-kappaB","activation","is","a","critical","regulator","of","human","granulocyte","apoptosis","in","vitro","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5853","tokens":["By","using","immunohistochemistry","with","antibodies","against","proteins","encoded","by","a","particular","gene","in","a","cluster",",","the","identity","of","the","cell","type","within","the","tumor","specimen","that","contributed","the","observed","gene","expression","pattern","could","be","determined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"656","tokens":["Insertion","of","oligonucleotides","spanning","the","DQB","X-box","(","but","not","the","DQB-W","region","or","the","DQB","Y-box",")","upstream","of","-141","in","a","DRA","reporter","plasmid","rescued","expression","to","nearly","wild-type","levels","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,1,2,0,0,1,2,0,1,2,2,0,0,1,2,2,0,0,0,0,0,0,0]}
{"id":"301","tokens":["MEASUREMENTS",":","The","binding","capacity","and","affinity","of","the","glucocorticoid","receptors","were","measured","and","compared","to","clinical","data","and","the","plasma","cortisol","concentrations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3284","tokens":["HIV-1","LTR","activity","in","human","CD40-activated","B","lymphocytes","is","dependent","on","NF-kappaB","."],"ner_tags":[1,2,0,0,5,6,6,6,0,0,0,9,0]}
{"id":"10447","tokens":["Moreover",",","electrophoretic","mobility","shift","assays","demonstrated","that","CMV","induced","the","formation","of","NF-kappaB","and","AP-1","complexes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0]}
{"id":"10678","tokens":["Acute","leukemia","with","promyelocytic","features","in","PML\/RARalpha","transgenic","mice","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"18197","tokens":["Our","results","provide","evidence","that","the","lysis","mechanism","in","the","ICR27","lymphoblasts","is","restored","when","functional","receptor","number","is","restored","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0]}
{"id":"17282","tokens":["The","recently","discovered","macrolide","FK506","has","been","demonstrated","to","have","potent","immunosuppressive","activity","at","concentrations","100-fold","lower","than","cyclosporin","A",",","a","cyclic","undecapeptide","that","is","used","to","prevent","rejection","after","transplantation","of","bone","marrow","and","organs",",","such","as","kidney",",","heart",",","and","liver","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10792","tokens":["Tat","also","superactivates","the","HIV-1","promoter","through","a","TAR","-independent","mechanism",",","including","tumor","necrosis","factor","alpha-induced","and","protein","kinase","C","(","PKC",")","-dependent","activation","of","NF-kappa","B",",","and","inhibitors","of","Tat","and","NF-kappa","B","cooperatively","down-regulate","this","Tat","-mediated","LTR","superactivation","."],"ner_tags":[0,0,0,0,1,2,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,10,0,0,0,0,9,0,9,10,0,0,0,9,0,1,0,0]}
{"id":"3831","tokens":["It","is","directly","implicated","in","the","emergence","of","the","age-related","immune","deficiency","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"397","tokens":["In","addition",",","the","Ah","receptor","complex","recognized","a","DNA","binding","site","for","B","cell","lineage-specific","activator","protein","(","BSAP",")","in","the","promoter","region","of","the","human","CD19","gene","which","is","similar","to","the","consensus","Ah","receptor","DNA","binding","site","."],"ner_tags":[0,0,0,0,9,10,10,0,0,1,2,2,0,9,10,10,10,10,0,9,0,0,0,1,2,0,0,0,1,2,0,0,0,0,0,1,2,2,2,2,2,0]}
{"id":"17395","tokens":["This","result","suggests","that","the","cAMP","response","element","binding","protein",",","CREB",",","is","involved","in","the","protein-TRE-DNA","complex","and","in","mediating","the","Tax","response","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,0,9,0,0,0,0,0,9,10,0,0,0,0,9,0,0]}
{"id":"14123","tokens":["CONCLUSIONS","."],"ner_tags":[0,0]}
{"id":"7792","tokens":["Differential","induction","of","interferon","(","IFN",")","-inducible","protein","10","following","differentiation","of","a","monocyte",",","macrophage","cell","lineage","is","related","to","the","changes","of","nuclear","proteins","bound","to","IFN","stimulus","response","element","and","kappaB","sites","."],"ner_tags":[0,0,0,9,10,10,10,10,10,10,0,0,0,0,7,0,7,8,0,0,0,0,0,0,0,9,10,0,0,1,2,2,2,0,1,2,0]}
{"id":"585","tokens":["The","increased","T","cell","response","after","RAI","therapy","is","probably","epitope","specific",",","rather","than","a","response","to","the","whole","TSHR","molecule","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"9512","tokens":["This","result",",","confirmed","by","competitions","with","each","GATA","site",",","demonstrated","the","higher","relative","affinity","(","at","least","sevenfold",")","of","site","3","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1262","tokens":["Using","this","technique","we","have","isolated","several","differentially","expressed","sequence","tags","(","DESTs",")","from","the","mouse","thymocyte","cell","line","WEHI","7.2","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,0,1,0,0,0,5,6,6,6,5,6,0]}
{"id":"566","tokens":["Chemical","cross-linking","with","125I-labeled","TGF-beta","1","showed","an","essentially","normal","TGF-beta","receptor","profile","in","EBV-positive","and","EBV-negative","Burkitt","'s","lymphoma","cell","lines",",","and","these","receptors","were","shown","to","be","functional","in","transducing","signals",",","as","evidenced","by","the","TGF-beta","1","-mediated","modulation","of","junB","gene","expression","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,9,10,0,0,5,6,6,6,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,1,2,0,0]}
{"id":"16629","tokens":["Neither","deletion","of","NF","kappa","B","nor","deletion","of","NFAT-1","decreased","activation","of","viral","replication","by","phorbol","ester","."],"ner_tags":[0,0,0,9,10,10,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"12527","tokens":["However",",","during","maturation","of","both","lineages","(","days","21","and","28",")",",","increased","expression","of","a","functionally","distinct","80","kDa","STAT5","isoform","was","observed",",","resulting","in","heterodimer","DNA-binding","complexes","containing","both","the","94","and","80","kDa","STAT5","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0]}
{"id":"15203","tokens":["Synergistic","transactivation","of","the","BMRF1","promoter","by","the","Z\/c-myb","combination","appears","to","involve","direct","binding","by","the","Z","protein","but","not","the","c-myb","protein","."],"ner_tags":[0,0,0,0,1,2,0,0,9,10,0,0,0,0,0,0,0,9,10,0,0,0,9,10,0]}
{"id":"14318","tokens":["The","emergence","of","nuclear","binding","proteins","was","investigated","using","interleukin-2","sequence","specific","oligonucleotide","probes","in","the","electrophoretic","mobility","shift","assay","."],"ner_tags":[0,0,0,9,10,10,0,0,0,1,2,2,2,2,0,0,0,0,0,0,0]}
{"id":"1877","tokens":["This","differential","binding","of","specific","NF-kappa","B\/Rel","subunits","is","likely","to","mediate","the","disparate","functions","of","these","two","NF-kappa","B\/Rel","binding","sites","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"11314","tokens":["We","overexpressed","AML1a","(","without","the","transcription-activating","domain",")","and","AML1b","(","with","the","domain",")","proteins","in","K562","leukemia","cells",",","which","can","be","induced","to","differentiate","into","hemoglobin-producing","cells","and","megakaryocytes","."],"ner_tags":[0,0,9,0,0,0,9,10,0,0,9,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,7,8,0,7,0]}
{"id":"6139","tokens":["Extracellular","signal-regulated","protein","kinase","(","ERK",")","-dependent","and","ERK-independent","pathways","target","STAT3","on","serine-727","in","human","neutrophils","stimulated","by","chemotactic","factors","and","cytokines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0,9,0]}
{"id":"18220","tokens":["Incubation","of","isolated","Ets-1","protein","with","purified","CaM","kinase","II","produced","phosphorylation","of","peptides","that","migrated","identically","to","those","found","in","cells","incubated","with","either","anti-IgM","or","ionomycin","."],"ner_tags":[0,0,9,10,10,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"10143","tokens":["Individual","mutation","of","the","DBF","or","AP3-L","site","as","well","as","the","double","mutation","AP-1","(","III",")","\/AP3-L","did","not","affect","HIV-1","replication","compared","to","that","of","the","wild-type","virus","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12334","tokens":["Dexamethasone","prevented","IL-8","and","tumor","necrosis","factor-alpha","secretion","in","ventilated","macrophages","."],"ner_tags":[0,0,9,0,9,10,10,0,0,7,8,0]}
{"id":"10280","tokens":["Involvement","of","the","N-terminal","region","of","the","human","mineralocorticoid","receptor","hormone-binding","domain","in","agonist","and","antagonist","binding","as","revealed","by","a","new","monoclonal","antibody","."],"ner_tags":[0,0,0,9,10,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"3364","tokens":["By","immunohistochemistry",",","p50","protein","was","detected","in","the","cytoplasm","and","nucleus","of","FDC",",","confirming","the","involvement","of","FDC","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,7,0]}
{"id":"14647","tokens":["The","microA","motif","was","required","for","microB-dependent","enhancer","activity",",","which","suggests","that","a","minimal","B","cell-specific","enhancer","is","composed","of","both","the","PU.1","and","Ets-1","binding","sites","."],"ner_tags":[0,1,0,0,0,0,1,2,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,1,2,2,2,2,0]}
{"id":"5750","tokens":["Moreover","T","cell","proliferation","was","unaffected","by","the","addition","of","blocking","Abs","to","both","IL-2","and","the","IL-2","receptor",",","demonstrating","that","this","form","of","costimulation","by","CD28","was","independent","of","IL-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,9,10,0,0,0,0,0,0,0,0,9,0,0,0,9,0]}
{"id":"7422","tokens":["In","the","cytoplasm","it","acts","as","a","dehydratase","in","the","regeneration","of","tetrahydrobiopterin",",","the","cofactor","for","aromatic","amino","acid","hydroxylases","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,9,10,10,10,0]}
{"id":"82","tokens":["We","have","purified","these","activities","and","found","that","the","principal","IL-2-inducible","component","bears","significant","relatedness","to","a","prolactin-induced","transcription","factor","first","identified","in","sheep","mammary","gland","tissue","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,10,0,0,0,7,8,8,8,0]}
{"id":"9307","tokens":["The","c-Jun","amino-terminal","kinase","(","JNK",")","phosphorylates","NFAT4","on","two","sites","."],"ner_tags":[0,9,10,10,0,9,0,0,9,0,0,0,0]}
{"id":"9246","tokens":["Our","results","identify","a","molecular","switch","for","lineage","specification","in","early","lymphoid","precursors","of","humans","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0]}
{"id":"1154","tokens":["Hemoglobin","switching","in","humans","is","accompanied","by","changes","in","the","ratio","of","the","transcription","factors",",","GATA-1","and","SP1","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,0]}
{"id":"1660","tokens":["More","than","half","of","the","expansions","involved","one","or","two","repeats",";","the","largest","was","11","repeats","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2639","tokens":["The","role","of","the","human","immunodeficiency","virus","(","HIV-1",")","Nef","protein","in","T","cell","activation","pathways","was","investigated","using","a","Jurkat","CD4+","cell","line","stably","transfected","with","a","Nef","expression","vector","."],"ner_tags":[0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0]}
{"id":"16543","tokens":["One","of","the","factors","bound","to","a","novel","dyad","symmetrical","sequence","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"4041","tokens":["The","extent","to","which","peptides","containing","chemically","and","post-translationally","modified","amino","acid","side","chains","are","recognized","by","primed","CTL","has","not","been","clearly","defined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,5,6,0,0,0,0,0,0]}
{"id":"1403","tokens":["The","receptor","for","the","macrophage","colony-stimulating","factor","(","or","colony-stimulating","factor","1","[","CSF-1","]",")","is","expressed","from","different","promoters","in","monocytic","cells","and","placental","trophoblasts","."],"ner_tags":[0,0,0,0,9,10,10,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,7,8,0,7,8,0]}
{"id":"11760","tokens":["Our","results","demonstrate","that","1.3E2","is","a","cellular","transduction","mutant","exhibiting","a","defect","in","a","step","that","is","required","by","several","different","stimuli","to","activate","NF-kappaB","."],"ner_tags":[0,0,0,0,5,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"365","tokens":["In","the","present","study",",","the","role","of","serine\/threonine","phosphatases","in","the","regulation","of","I","kappa","B","alpha","phosphorylation","was","investigated","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"1773","tokens":["The","TNF","alpha","-activated","NF-kappa","B","was","transcriptionally","functional","."],"ner_tags":[0,9,10,0,9,10,0,0,0,0]}
{"id":"1766","tokens":["Our","results","point","to","an","important","difference","between","antiandrogens","and","antagonists","of","other","steroid","hormone","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"5407","tokens":["Galectin-3","is","widely","distributed","in","various","tissues","and","cell","types","and","is","expressed","in","many","leukocytes",",","with","the","notable","exception","of","B","and","T","lymphocytes","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"11766","tokens":["In","this","manuscript","we","have","investigated","the","molecular","mechanisms","by","which","T","cell","lines","stimulated","with","phorbol","12-myristate","13-acetate","(","PMA",")","and","phytohemagglutin","(","PHA",")","display","significantly","higher","levels","of","NF-kappa","B1","encoding","transcripts","than","cells","stimulated","with","tumor","necrosis","factor-alpha",",","despite","the","fact","that","both","stimuli","activate","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,9,10,0,3,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"15328","tokens":["Human","fibroblasts","contained","roughly","the","same","level","of","microsomal","p-nitrophenyl","sulfatase","activity","as","that","previously","observed","in","hepatic","microsomes","."],"ner_tags":[7,8,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,7,8,0]}
{"id":"16500","tokens":["Nuclear","run-on","assays","and","mRNA","stability","studies","demonstrated","that","M-CSF","regulates","c-jun","expression","by","both","an","increase","in","transcription","rate","and","a","prolongation","in","the","half-life","of","c-jun","transcripts","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0]}
{"id":"11315","tokens":["The","AML1a-transfected","K562","cells","had","a","reduced","capacity","to","differentiate","in","the","presence","of","sodium","n-butyrate","but","not","in","the","presence","of","other","inducers",",","such","as","hemin",",","1-beta-D-arabinofuranosylcytosine",",","and","herbimycin","A","."],"ner_tags":[0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1530","tokens":["In","day","7","and","day","10","erythroid","precursors","cultured","with","Steel","factor",",","SCL","protein","was","increased","significantly","compared","to","control","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,9,10,0,9,10,0,0,0,0,0,0,0]}
{"id":"13036","tokens":["The","capacity","of","neonatal","T","cells","to","secrete","interleukin-2","(","IL-2",")","has","been","reported","to","be","variable","."],"ner_tags":[0,0,0,7,8,8,0,0,9,0,9,0,0,0,0,0,0,0,0]}
{"id":"16044","tokens":["NAC","and","other","thiol","compounds","also","blocked","the","activation","of","NF-kappa","B","by","cycloheximide",",","double-stranded","RNA",",","calcium","ionophore",",","TNF-alpha",",","active","phorbol","ester",",","interleukin-1",",","lipopolysaccharide","and","lectin","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,3,4,0,0,0,0,9,0,0,0,0,0,9,0,0,0,9,0]}
{"id":"12886","tokens":["Finally",",","we","observed","that","activated","STAT5a","and","STAT5b","proteins","form","distinct","Fc","gamma","RI","GAS","binding","patterns","in","T","and","NK","cells",",","suggesting","that","they","might","have","different","roles","in","gene","regulation","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16256","tokens":["1",",","25-Dihydroxyvitamin","D3","receptor","RNA",":","expression","in","hematopoietic","cells","."],"ner_tags":[3,4,4,4,4,4,0,0,0,7,8,0]}
{"id":"14995","tokens":["These","results","can","not","be","explained","by","receptor","down-regulation","due","to","higher","level","of","mineralocorticoids","of","the","zona","glomerulosa","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11163","tokens":["Indeed",",","the","combination","of","NE","and","threshold","of","cathepsin","G","increased","the","binding","of","PAC-1","approximately","5.5-fold","over","basal","values","measured","on","nontreated","platelets",",","whereas","this","binding","raised","only","by","approximately","3-fold","in","threshold","of","cathepsin","G-stimulated","platelets","(","p","<","0.05",")","."],"ner_tags":[0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0]}
{"id":"17364","tokens":["The","human","TFIID","polypeptide","has","339","amino","acids","and","a","molecular","size","of","37",",","745","daltons","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5055","tokens":["A","mammalian","histone","deacetylase","related","to","the","yeast","transcriptional","regulator","Rpd3p","[","see","comments","]"],"ner_tags":[0,9,10,10,0,0,0,9,10,10,9,0,0,0,0]}
{"id":"5444","tokens":["A","cell","type-specific","enhancer","in","the","human","B7.1","gene","regulated","by","NF-kappaB","."],"ner_tags":[0,1,2,2,0,0,1,2,2,0,0,9,0]}
{"id":"7883","tokens":["After","tyrosine","phosphorylation","by","src","and","possibly","syk","protein","tyrosine","kinases","SIT","recruits","the","SH2","domain-containing","tyrosine","phosphatase","SHP2","via","an","immunoreceptor","tyrosine-based","inhibition","motif","."],"ner_tags":[0,0,0,0,9,0,0,9,9,10,10,9,0,0,9,10,10,10,9,0,0,0,0,0,0,0]}
{"id":"1913","tokens":["The","EGR-1","promoter","contains","six","CC","(","A\/T",")","6GG","(","CArG",")","motifs","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12573","tokens":["In","addition",",","genistein","was","a","very","low-potency","agonist",",","having","an","EC50","of","1.5","microM","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10683","tokens":["During","their","first","year","of","life",",","all","the","PML\/","RARalpha","transgenic","mice","have","an","abnormal","hematopoiesis","that","can","best","be","described","as","a","myeloproliferative","disorder","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15380","tokens":["c-Jun","protein","isolated","from","phorbol","ester-induced","cells","did","not","target","c-Fos","for","degradation",",","which","suggests","that","c-Fos","is","transiently","stabilized","after","stimulation","of","cell","growth","."],"ner_tags":[9,0,0,0,5,6,6,0,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"13907","tokens":["We","conclude","that","the","t","(","10",";","11",")","(","p13",";","q14",")","indicates","CALM","and","MLL","rearrangements","in","morphologically","distinct","subsets","of","acute","leukemia","and","may","be","associated","with","a","poor","prognosis","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13225","tokens":["We","have","analyzed","de","novo","radiation-induced","translocations","between","the","Xi","and","autosomes","to","study","the","maintenance","and","spreading","of","X-chromosome","inactivation","(","X","inactivation",")","in","relation","to","the","position","of","the","X-inactivation","center","(","XIC",")","\/XIST","in","differentiated","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,7,8,0]}
{"id":"18317","tokens":["Jak1",",","Jak2",",","and","Stat1","were","immunoprecipitated","from","control","and","interferon-treated","cells",",","and","tyrosine","phosphorylation","of","these","proteins",",","detected","by","antiphosphotyrosine","immunoblotting","was","used","to","measured","their","activation","."],"ner_tags":[9,0,9,0,0,9,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4130","tokens":["Precise","alignment","of","sites","required","for","mu","enhancer","activation","in","B","cells","."],"ner_tags":[0,1,2,2,0,0,1,2,0,0,7,8,0]}
{"id":"18298","tokens":["These","results","suggest","a","role","for","altered","balance","of","Stat1","and","Stat3","transcriptional","activity","in","the","regulation","of","T","cell","differentiation","and","in","the","pathogenesis","of","inflammatory","synovitis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0]}
{"id":"495","tokens":["All","the","markers","considered","were","sufficiently","sensitive",",","but","among","them",",","Platelet","Factor","IV","was","the","most","reliable","to","the","hormonal","ovulatory","situation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"10845","tokens":["However",",","the","experimentally","derived","B-lymphoblastoid","cell","line",",","clone","13",",","expresses","high","levels","of","HLADQ","in","the","absence","of","HLA-DR","and","HLA-DP",",","despite","its","mapping","by","complementation","analysis","to","this","group","."],"ner_tags":[0,0,0,0,0,5,6,6,0,5,6,0,0,0,0,0,9,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14066","tokens":["The","total","populations","of","CD4","+",",","CD8","+","and","CD56","+","[","possible","T-cell","and","natural","killer","(","T\/NK",")","populations","]","in","the","BM","of","ST","patients","and","MRD+\/LT","patients","were","significantly","(","p","<",".01",")","low","."],"ner_tags":[0,0,0,0,9,0,0,9,0,0,9,0,0,0,7,0,7,8,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4238","tokens":["Activation","protein","1","-dependent","transcriptional","activation","of","interleukin","2","gene","by","Ca2+\/calmodulin","kinase","type","IV\/Gr","."],"ner_tags":[9,10,10,0,0,0,0,1,2,2,0,9,10,10,10,0]}
{"id":"2978","tokens":["The","intracellular","events","that","lead","to","the","inactivation","of","I","kappa","B",",","i.e.","the","activation","of","NF-kappa","B",",","are","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"1432","tokens":["We","examined","these","clones","for","differences","in","nuclear","factor","(","NF",")","-kappa","B","activity","which","might","account","for","the","observed","phenomenon","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"12495","tokens":["On","the","other","hand",",","the","receptor","characteristics","in","Cushing","'s","disease","patients","were","within","the","normal","range","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12409","tokens":["Down-regulation","of","human","granzyme","B","expression","by","glucocorticoids","."],"ner_tags":[0,0,0,9,10,0,0,0,0]}
{"id":"1524","tokens":["In","this","report",",","we","studied","the","role","of","SCL","in","the","proliferation","of","human","peripheral","blood","burst-forming","unit-erythroid","(","BFU-E",")","and","the","effects","of","Steel","factor","on","SCL","expression","in","proliferating","erythroid","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,0,7,0,0,0,0,0,9,10,0,9,0,0,7,8,8,0]}
{"id":"11373","tokens":["B","cells","derived","from","patients","with","X-linked","severe","combined","immunodeficiency","(","X-SCID",")","are","deficient","in","gammac","and","provide","a","useful","model","in","which","to","dissect","the","role","of","this","subunit","in","IL-4","-mediated","signaling","."],"ner_tags":[7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"9947","tokens":["The","binding","site","for","nuclear","factor-kappaB","(","NF-kappaB",")","is","present","at","the","promoter","region","of","the","germline","Cepsilon","gene",",","but","there","is","little","information","on","whether","this","factor","is","involved","in","regulating","IgE","synthesis","by","human","B","cells","."],"ner_tags":[0,1,2,0,9,10,0,9,0,0,0,0,0,1,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,8,0]}
{"id":"11535","tokens":["In","healthy","subjects",",","the","mean","GC-R","Bmax","and","Kd","in","quiescent","PBMC","of","the","GC-sensitive","group","were","2.89","+\/-","1.23","fmol\/10","(","6",")","cells","and","4.00","+\/-","2.24","nM",",","respectively","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16770","tokens":["Since","the","Rhom-2","gene","is","such","a","common","site","of","chromosomal","damage","in","T-cell","tumors",",","the","consistency","of","translocations","near","the","rhombotin","gene","was","further","examined","."],"ner_tags":[0,0,1,2,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"213","tokens":["Genomic","sequence","upstream","of","the","Fc","gamma","RIC","gene","was","cloned","and","subjected","to","primer","extension","analysis",",","which","demonstrated","a","single","transcription","initiation","site","without","a","TATA","box","."],"ner_tags":[0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,0]}
{"id":"1982","tokens":["We","have","investigated","the","antigenic","specificity","of","47","HSV-specific","CD4+","T-cell","clones","recovered","from","the","HSV-2","buttock","and","thigh","lesions","of","five","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15358","tokens":["Like","the","105-kDa","precursor",",","it","contains","an","amino-terminal","Rel-related","domain","of","about","300","amino","acids","and","a","carboxy-terminal","domain","containing","six","full","cell","cycle","or","ankyrin","repeats","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0,0,9,10,10,0,9,10,0]}
{"id":"8486","tokens":["Interdomain","B","in","ZAP-70","regulates","but","is","not","required","for","ZAP-70","signaling","function","in","lymphocytes","."],"ner_tags":[9,10,0,9,0,0,0,0,0,0,9,0,0,0,7,0]}
{"id":"2049","tokens":["Antibodies","against","the","NF-kappa","B","and","Rel","proteins","and","UV","cross-linking","studies","revealed","the","presence","of","c-Rel","and","p65","and","the","absence","of","p50","in","the","TF","complex","and","further","showed","that","c-Rel\/p65","heterodimers","selectively","bound","to","the","TF","kappa","B-like","site","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,9,10,0,0,0,0,9,10,0,0,0,0,1,2,2,2,0]}
{"id":"1855","tokens":["Hence",",","integration","of","signals","that","lead","to","T","cell","activation","occurs","at","the","level","of","JNK","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"17617","tokens":["We","conclude","that","p56","exists","in","cytosol","in","a","higher","order","complex","containing","hsp70","and","hsp90",",","both","of","which","in","turn","have","been","found","to","be","associated","with","untransformed","steroid","receptors","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"11908","tokens":["Nuclear","factor-kappa","B","potently","up-regulates","the","promoter","activity","of","RANTES",",","a","chemokine","that","blocks","HIV","infection","."],"ner_tags":[9,10,10,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"10154","tokens":["Dexamethasone",",","up","to","a","concentration","of","1","mumol\/L",",","neither","affected","significantly","the","release","of","granule","enzymes","nor","interfered","with","PAF","binding","to","its","membrane","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,0,0,0,9,10,0]}
{"id":"13565","tokens":["When","used","in","combination",",","the","polyamides","inhibit","virus","replication","by",">","99","%","in","isolated","human","peripheral","blood","lymphocytes",",","with","no","detectable","cell","toxicity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,0,0,0,0,0,0,0]}
{"id":"5814","tokens":["Induction","of","Bcl-x","(","L",")","expression","by","human","T-cell","leukemia","virus","type","1","Tax","through","NF-kappaB","in","apoptosis-resistant","T-cell","transfectants","with","Tax","."],"ner_tags":[0,0,9,10,10,10,0,0,9,10,10,10,10,10,10,0,9,0,5,6,6,0,9,0]}
{"id":"1339","tokens":["The","IL-2","octamer","motif","is","a","composite","cis-element","which","binds","Oct-1","and","Oct-2","as","well","as","a","TPA\/Ca","(","2+",")","-inducible","nuclear","factor",",","previously","termed","octamer-associated","protein","(","OAP40",")","."],"ner_tags":[0,1,2,2,0,0,0,1,0,0,9,0,9,0,0,0,0,9,10,10,10,10,10,10,0,0,0,9,10,0,9,0,0]}
{"id":"14833","tokens":["We","found","that","GATA-1","and","tal-1","genes","are","coexpressed","in","these","three","lineages","."],"ner_tags":[0,0,0,1,2,2,2,0,0,0,0,0,0,0]}
{"id":"17215","tokens":["In","addition","to","these","elements",",","we","identified","a","second","regulatory","element",",","the","N","element","with","the","sequence","5'-GGAACCTCCCCC-3'","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,0,0,1,2,0,0,0,0,0]}
{"id":"14942","tokens":["Electrophoretic","mobility","shift","assays","revealed","three","specific","protein-DNA","complexes","formed","with","sequences","of","the","EBNA2","responsive","element","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,1,2,2,0]}
{"id":"1310","tokens":["The","major","GC-box","binding","activity","A1","was","purified","and","identified","as","the","transcription","factor","Sp1","."],"ner_tags":[0,0,1,0,0,9,0,0,0,0,0,0,9,10,10,0]}
{"id":"13463","tokens":["Metabolic","labeling","combined","with","pulse-chase","experiments","and","biochemical","analysis","showed","that","the","majority","of","class","II","molecules","in","infected","cells","became","resistant","to","endoglycosidase","H",",","consistent","with","normal","Golgi","processing","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"6955","tokens":["Latent","membrane","protein","1","(","LMP1",")","acts","like","a","permanently","activated","receptor","of","the","tumor","necrosis","factor","(","TNF",")","-receptor","superfamily","and","is","absolutely","required","for","B","cell","immortalization","by","Epstein-Barr","virus","."],"ner_tags":[9,10,10,10,0,9,0,0,0,0,9,10,10,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1240","tokens":["Both","NF-kappa","B","precursors","and","I","kappa","B","alpha","became","strongly","phosphorylated","with","the","same","kinetics","."],"ner_tags":[0,9,10,0,0,9,10,10,10,0,0,0,0,0,0,0,0]}
{"id":"15000","tokens":["The","data","show","that","hypertension","in","preeclamptic","women","can","be","treated","by","Urapidil","without","side","effects","or","reflex-tachycardia","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8966","tokens":["These","agents","also","significantly","decreased","TNF","-and","LPS-stimulated","increases","in","HUVEC","surface","VCAM-1","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,9,10,10,0]}
{"id":"256","tokens":["The","activation","of","STAT","nuclear","factors","was","studied","by","electrophoretic","mobility","shift","assay","using","a","gamma","activation","site","(","GAS",")","probe","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,1,2,2,0,1,0,0,0]}
{"id":"4590","tokens":["Effects","of","interleukin-10","on","human","peripheral","blood","mononuclear","cell","responses","to","Cryptococcus","neoformans",",","Candida","albicans",",","and","lipopolysaccharide","."],"ner_tags":[0,0,9,0,7,8,8,8,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17023","tokens":["ZRE-B","is","therefore","not","part","of","the","R-","inducible","enhancer","."],"ner_tags":[1,0,0,0,0,0,0,1,2,2,0]}
{"id":"9658","tokens":["Furthermore",",","the","degree","of","CN","inhibition","was","reflected","by","a","similar","degree","of","reduction","in","lymphocyte","proliferation","and","IFN-gamma","production","in","the","allogeneic","mixed","lymphocyte","cultures","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,5,6,6,6,0]}
{"id":"14723","tokens":["A","similar","comparison","with","protease-treated","extracts","prepared","from","Jurkat","cells","demonstrated","the","presence","of","the","band","1pk","activity","despite","an","absence","of","the","native","RFX","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"16571","tokens":["Similarly",",","covalent","modification","of","free","sulfhydryl","groups","with","diamide","(","reversible",")","or","N-ethylmaleimide","(","irreversible",")","results","in","a","complete","loss","of","DNA","binding","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16647","tokens":["This","tight","correlation","between","c-jun","expression",",","the","generation","of","AP-1","activity",",","and","differentiation","suggests","a","critical","role","for","this","gene","and","transcriptional","complex","during","this","process","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"13738","tokens":["We","have","recently","described","an","inherited","over-expression","of","the","macrophage","scavenger","receptor","(","SR",")","in","blood","monocytes","from","members","of","a","kindred",",","only","two","of","whom","displayed","extensive","xanthomatosis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10900","tokens":["BSAP","failed","to","trans-activate","CD19","promoter","constructs","in","B","cells","or","non-B","cells",",","suggesting","that","cis","elements","such","as","the","PyG","and","GC","boxes","are","also","necessary","for","high","level","CD19","promoter","expression","."],"ner_tags":[9,0,0,0,1,2,2,0,7,8,0,7,8,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,1,2,0,0]}
{"id":"50","tokens":["Transient","transfection","experiments","show","that","several","elements","in","the","promoter-proximal","region","of","the","IL-2R","alpha","gene","contribute","to","IL-1","responsiveness",",","most","importantly","an","NF-kappa","B","site","conserved","in","the","human","and","mouse","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,1,2,2,0,0,9,0,0,0,0,0,1,2,2,0,0,0,1,2,2,2,0]}
{"id":"5823","tokens":["Our","findings","suggest","that","constitutive","expression","of","Bcl-x","(","L",")","induced","by","Tax","through","the","NF-kappaB","pathway","contributes","to","the","inhibition","of","apoptosis","in","CTLL-2","cells","after","IL-2","deprivation","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,0,0,9,0,0,9,0,0,0,0,0,0,0,0,5,6,0,9,0,0]}
{"id":"13091","tokens":["Percentage","of","apoptotic","cells","was","determined","by","in-situ","labelling","of","DNA","strand","breaks","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"5959","tokens":["By","the","time","of","diagnosis","of","T-PLL",",","the","clone","contains","many","more","genetic","changes","in","the","form","of","additional","translocations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7753","tokens":["Lipopolysaccharide","(","LPS",")","stimulation","of","human","neutrophils","is","known","to","result","in","activation","of","p38","mitogen-activated","protein","kinase","(","MAPk",")",";","however",",","the","upstream","activator","(","s",")","of","p38","MAPk","is","unknown",",","and","consequences","of","p38","MAPk","activation","remain","largely","undefined","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0,0,0,0,9,10,0,0,0,0,9,10,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"15228","tokens":["Thus",",","Elf-1","is","a","novel","transcription","factor","that","appears","to","be","required","for","the","T-cell-receptor-mediated","trans","activation","of","HIV-2","gene","expression","."],"ner_tags":[0,0,9,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"623","tokens":["Alanine","substitutions","introduced","at","two","serine","residues","positioned","within","this","N-terminal","regulatory","region","of","I","kappa","B","alpha","also","yielded","constitutive","repressors","that","escaped","from","Tax","-induced","turnover","and","that","potently","inhibited","immune","activation","pathways","for","NF-kappa","B","induction",",","including","those","initiated","from","antigen","and","cytokine","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,10,10,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"2865","tokens":["Calmodulin","antagonists",",","compound","R24571","and","trifluoperazine",",","blocked","the","Zp","activation","with","anti-Ig","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,0,9,0]}
{"id":"18255","tokens":["Collectively",",","our","results","demonstrate","that","nuclear","translocation","and","activation","of","NF-kappa","B","rank","among","the","short-term","cellular","responses","elicited","following","CD30","ligation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"17801","tokens":["In","the","first","patients","studied",",","we","found","no","significant","modification","in","the","expression","of","the","97","kDa","Ca","(","2+",")","-ATPase","by","Western","blotting","using","the","PL\/IM","430","monoclonal","antibody","which","specifically","recognized","this","isoform","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0]}
{"id":"9733","tokens":["Furthermore",",","it","is","highly","expressed","in","Burkitt","'s","lymphoma","cells","and","may","participate","in","the","pathogenesis","of","this","disease","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0]}
{"id":"671","tokens":["These","studies","suggest","that","the","specificities","of","some","of","the","known","biological","functions","of","ZEBRA","are","not","dependent","upon","the","nature","of","the","activation","domain","present","within","ZEBRA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,10,0,9,0]}
{"id":"3219","tokens":["Differential","nuclear","localization","of","p50",",","p52",",","and","RelB","proteins","in","human","accessory","cells","of","the","immune","response","in","situ","."],"ner_tags":[0,0,0,0,9,0,9,0,0,9,0,0,7,8,8,0,0,0,0,0,0,0]}
{"id":"2861","tokens":["Since","anti-Ig","crosslinking","leads","to","activation","of","protein","kinase","C","(","PKC",")","and","an","increase","in","intracellular","calcium","level",",","Zp","was","tested","for","the","response","to","these","cellular","factors","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,9,10,0]}
{"id":"9485","tokens":["The","human","G0\/G1","switch","gene",",","G0S2",",","has","potential","NFAT-binding","sites","in","the","5","'","flank","and","encodes","a","small","basic","potential","phosphoprotein","of","unknown","function","."],"ner_tags":[0,1,2,2,2,0,1,0,0,0,1,2,0,0,1,2,2,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"11320","tokens":["Identification","of","sequence","alterations","in","the","upstream","regulatory","region","of","the","estrogen","receptor","gene","in","an","ER-negative","breast","cancer","cell","line","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,1,2,2,0,0,5,6,6,6,6,0]}
{"id":"7700","tokens":["STAT1",",","which","is","activated","in","response","to","many","lymphocyte-activating","cytokines","including","the","interferons",",","is","essential","for","cell-mediated","immunity",",","as","the","absence","of","this","protein","is","associated","with","prominent","defects","in","the","ability","to","control","viral","infections","."],"ner_tags":[9,0,0,0,0,0,0,0,0,9,10,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17109","tokens":["The","two","proteins","differ","by","a","14-amino","acid","serine-rich","insertion","present","in","one","of","the","CREB","isoforms","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,9,10,0]}
{"id":"5511","tokens":["Recent","reports","suggest","that","serine","phosphorylation","of","STATs","also","is","involved","in","the","regulation","of","STAT","-mediated","gene","transcription","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"9755","tokens":["We","therefore","compared","the","turnover","of","I","kappa","B","alpha","and","I","kappa","B","beta","in","mature","B","cells","and","HeLa","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,0,9,10,10,10,0,7,8,8,0,5,6,0]}
{"id":"2536","tokens":["In","conclusion",",","MDHM-stimulated","induction","of","cytokine","mRNA","expression","was","accompanied","by","different","proto-oncogene","responses","in","PBMo","and","THP-1","cells","."],"ner_tags":[0,0,0,0,0,0,3,4,0,0,0,0,0,1,0,0,7,0,5,6,0]}
{"id":"15745","tokens":["There","is","little","information","available","on","the","response","of","NF","kappa","B","to","cytokines","in","normal","human","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,7,8,8,0]}
{"id":"10005","tokens":["Using","a","radiolabeled","chemical","probe",",","we","here","purified","a","target","of","SR","31747A","and","called","it","SR","31747A-binding","protein","(","SR-BP",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"7291","tokens":["Of","86","patients","with","a","chronic","MPD",",","71","(","82","%",")","exhibited","an","allele","ratio","greater","than","3",":","1",",","whereas","only","10","(","12","%",")","of","86","age-matched","control","subjects","showed","a","skewed","XCI","pattern","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18505","tokens":["The","protein","shows","significant","sequence","similarities","to","the","family","of","G-protein","coupled","chemokine","receptors","and","turned","out","to","be","identical","to","the","recently","described","receptor","EBI1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"18535","tokens":["Individually","or","collectively",",","none","of","the","three","enhancer-binding","proteins","(","LEF-1",",","Ets-1",",","and","TFE-3",")","could","activate","transcription","in","the","absence","of","Sp1","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,0,9,0,0,9,0,0,0,0,0,0,0,0,9,0]}
{"id":"14671","tokens":["In","contrast",",","TNFRp55-deficient","mice","are","severely","impaired","to","clear","L.","monocytogenes","and","readily","succumb","to","infection","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12342","tokens":["We","have","found","that","these","different","sets","of","signals","target","a","common","cis-acting","element","in","the","promoter","of","this","gene",",","the","IRF-1","gamma-activated","site","(","GAS",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,1,0,0]}
{"id":"11024","tokens":["Because","transgene","expression","was","regulated","by","the","proximal","promoter","of","the","murine","lck","gene","and","this","promoter","is","inactivated","in","T","cells","that","exit","the","thymus",",","the","mutant","hCaMKIV","is","not","present","in","peripheral","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,1,2,2,0,0,0,0,0,0,7,8,0,0,0,0,0,0,9,10,0,0,0,0,7,8,8,0]}
{"id":"8238","tokens":["Similarly",",","D3-induced","monocyte","differentiation","of","normal","myeloid","progenitor","cells","was","associated","with","increased","capacity","to","generate","E1","from","E2","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2273","tokens":["Much","higher","concentrations","of","other","antioxidants","--","including","ascorbic","acid",",","trolox",",","alpha-tocopherol",",","butylated","hydroxytoluene",",","and","the","5-lipoxygenase","inhibitor","zileuton","--","did","not","affect","the","production","of","these","cytokines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"2493","tokens":["Our","data","also","suggest","that","whilst","NF-kappa","B","may","be","an","essential","component","of","LMP1","signal","transduction",",","other","cell-specific","factors","may","be","required","to","effect","some","functions","of","the","viral","protein","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"6750","tokens":["Interleukin","(","IL",")","-4","plays","an","important","role","in","IgE","synthesis","in","B","cells","and","in","Th2","differentiation","in","T","cells","."],"ner_tags":[9,10,10,10,10,0,0,0,0,0,9,0,0,7,8,0,0,0,0,0,5,6,0]}
{"id":"11598","tokens":["Early","viral","RNA","splicing","patterns","also","differ","between","wild-type","and","dl337-infected","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"5450","tokens":["Deletional","and","site-directed","mutagenesis","revealed","the","presence","of","multiple","functionally","critical","cis","elements","within","this","region",",","one","of","which","was","a","nuclear","factor","(","NF",")","-kappaB","consensus","sequence","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0]}
{"id":"5324","tokens":["Rel-deficient","T","cells","exhibit","defects","in","production","of","interleukin","3","and","granulocyte-macrophage","colony-stimulating","factor","."],"ner_tags":[7,8,8,0,0,0,0,0,9,10,0,9,10,10,0]}
{"id":"12171","tokens":["A","specific","inhibitor","of","caspases",",","zVAD-FMK",",","prevents","triptolide-induced","PARP","degradation","and","DNA","fragmentation","but","not","growth","arrest","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"12219","tokens":["EBV","immediate-early","gene","transcripts","(","BZLF1",",","BRLF1",",","and","BMLF1",")","encoded","in","the","BamHI","Z",",","R",",","and","M","fragments","could","be","detected","by","in","situ","RT-PCR","in","the","EBV","producer","cell","line","B95.8","."],"ner_tags":[3,4,4,4,0,3,0,3,0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"557","tokens":["In","seven","EBV-B","cell","clones","or","lines","differing","in","their","capacity","to","secrete","IL-2",",","the","activity","of","the","IL-2","promoter","correlated","well","with","the","status","of","IL-2","secretion","."],"ner_tags":[0,0,5,6,6,0,0,0,0,0,0,0,0,9,0,0,0,0,0,1,2,0,0,0,0,0,0,9,0,0]}
{"id":"2057","tokens":["These","findings","are","consistent","with","the","postulated","role","for","TN","as","a","natural","antagonist","to","FN","action",",","and","suggest","that","T","cell","responses","occurring","at","tissue","sites","in","which","TN","is","expressed","could","be","influenced","by","its","presence","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"1445","tokens":["Southern","analysis","using","a","human","progesterone","receptor","(","hPR",")","cDNA","probe","identified","a","germline","TaqI","restriction","fragment","length","polymorphism","(","RFLP",")","defined","by","two","alleles",":","T1",",","represented","by","a","2.7","kb","fragment",";","and","T2",",","represented","by","a","1.9","kb","fragment","and","characterised","by","an","additional","TaqI","restriction","site","with","respect","to","T1","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,2,2,0,0,1,2,2,2,2,2,0,1,0,0,0,0,0,0,1,0,0,0,0,1,2,2,0,0,1,0,0,0,0,1,2,2,0,0,0,0,0,1,2,2,0,0,0,1,0]}
{"id":"432","tokens":["2.","Danazol","did","not","alter","the","degradation","rate","of","ER","mRNA","in","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,3,4,0,7,0]}
{"id":"13838","tokens":["BACKGROUND",":","The","class","II","transactivator","(","CIITA",")","is","a","bi-","or","multifunctional","domain","protein","that","acts","as","a","transcriptional","activator","and","plays","a","critical","role","in","the","expression","of","MHC","class","II","genes","."],"ner_tags":[0,0,0,9,10,10,0,9,0,0,0,9,10,10,10,10,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"12165","tokens":["CONCLUSIONS",":","Intestinal","epithelial","cells","initiate","an","inflammatory","response","with","resulting","neutrophil-mediated","tissue","damage","in","response","to","E.","histolytica","infection",";","this","inflammatory","cascade","can","be","blocked","by","inhibiting","the","transcription","of","genes","regulated","by","nuclear","factor","kappaB","."],"ner_tags":[0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"11825","tokens":["NO","derived","from","nNOS","in","glia","inhibits","the","transcription","factor","nuclear","factor","kappaB","(","NF","kappaB",")","as","NOS","inhibitors","enhance","basal","NF","kappaB","activation","."],"ner_tags":[0,0,0,9,0,7,0,0,9,10,9,10,10,0,9,10,0,0,0,0,0,0,9,10,0,0]}
{"id":"15600","tokens":["Still","a","more","essential","rise","in","the","number","of","receptors","is","observed","in","mid-age","hypertensive","patients","than","in","elderly","ones","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16355","tokens":["Interestingly",",","the","cloned","TCF-1","alpha","protein","is","a","potent","transcriptional","activator","of","the","human","TCR","alpha","enhancer","in","nonlymphoid","cell","lines",",","whereas","the","activity","of","the","endogenous","protein","in","T","cell","lines","is","strongly","dependent","on","an","additional","T","cell-specific","protein","that","interacts","with","the","core","enhancer","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,9,10,0,0,1,2,2,2,0,5,6,6,0,0,0,0,0,0,9,10,0,5,6,6,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0]}
{"id":"635","tokens":["These","included","vimentin",",","correlating","to","cell","shape","changes",",","cytokeratins","8","and","18",",","associated","with","differentiated","cell","types","of","prostate","epithelia",",","and","neuron-specific","enolase","and","serotonin",",","associated","with","neuroendocrine","cells","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,9,10,10,10,0,0,0,7,8,8,0,0,0,0,0,9,10,0,0,0,0,0,7,8,0]}
{"id":"9936","tokens":["Activation","of","the","nuclear","factor","of","activated","T","cells","transcription","factor","(","NF-AT",")","is","a","key","event","underlying","lymphocyte","action","."],"ner_tags":[0,0,0,9,10,10,10,10,10,9,10,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"1293","tokens":["Finally",",","these","short-term","systemic","effects","were","not","associated","with","any","of","the","noticeable","side-effects","usually","observed","during","long-term","treatment","with","glucocorticoids","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8682","tokens":["Tax","stimulated","transcription","through","NF-kappaB","and","the","cyclic","AMP-responsive","element-like","sequence","in","the","HTLV-1","promoter","."],"ner_tags":[9,0,0,0,9,0,0,1,2,2,2,0,0,0,0,0]}
{"id":"17045","tokens":["In","all","cell","lines","where","1",",","25","(","OH",")","2D3","binding","to","a","receptor","was","detectable",",","the","receptor","had","the","typical","sedimentation","coefficient","of","3.7","S","on","sucrose","density","gradient","analysis","."],"ner_tags":[0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9125","tokens":["At","10","to","100","micromol\/L","for",">","24","hours",",","oleate","inhibited","the","expression","of","all","adhesion","molecules","tested","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"11106","tokens":["However",",","a","substantial","decrease","of","AML1\/ETO","transcripts","was","seen","following","autologous","PBSCT","."],"ner_tags":[0,0,0,0,0,0,3,4,0,0,0,0,0,0]}
{"id":"13184","tokens":["To","further","characterize","altered","expression","of","TCRzeta",",","p56","(","lck",")",",","and","impaired","activation","of","NFkappaB",",","T","lymphocytes","were","obtained","from","65","patients","with","RCC",",","the","majority","of","whom","were","receiving","combination","cytokine","therapy","[","interleukin","(","IL",")","-2",",","IFN","alpha","-containing","regimens","]","and","37","control","individuals","."],"ner_tags":[0,0,0,0,0,0,9,0,9,10,10,10,0,0,0,0,0,9,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,10,10,10,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"13821","tokens":["Using","deletion","constructs",",","we","have","defined","an","active","promoter","region","of","1056","bp","."],"ner_tags":[0,1,2,0,0,0,0,0,1,2,2,0,0,0,0]}
{"id":"6536","tokens":["Patients","with","GC-insensitive","asthma","expressed","a","significantly","higher","number","of","GCRbeta-immunoreactive","cells","in","their","BAL","and","peripheral","blood","than","GC-sensitive","asthmatics","or","normal","control","subjects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7706","tokens":["Studies","into","the","effect","of","tyrosine","phosphatase","inhibitor","phenylarsine","oxide","on","NFkappaB","activation","in","T","lymphocytes","during","aging",":","evidence","for","altered","IkappaB-alpha","phosphorylation","and","degradation","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,9,0,0,7,8,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"17072","tokens":["To","determine","whether","different","cellular","factors","were","involved","in","E3","regulation","in","lymphocytes","as","compared","with","HeLa","cells",",","both","DNA","binding","and","transfection","analysis","with","the","E3","promoter","in","both","cell","types","were","performed","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,7,0,0,0,5,6,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0]}
{"id":"304","tokens":["In","vivo",",","there","was","no","change","in","the","number","of","receptors","per","cell","in","patients","with","sepsis","or","septic","shock","as","compared","to","healthy","controls","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12958","tokens":["Glucocorticoid-induced","apoptosis","was","investigated","in","glucocorticoid-sensitive","6TG1.1","and","resistant","ICR27TK.3","human","leukemic","T","cells","."],"ner_tags":[0,0,0,0,0,5,6,0,5,6,7,8,8,8,0]}
{"id":"11879","tokens":["Rapid","Ca2+-mediated","activation","of","Rap1","in","human","platelets","."],"ner_tags":[0,0,0,0,9,0,7,8,0]}
{"id":"4744","tokens":["In","the","present","study",",","we","further","analyzed","the","effect","of","ML-9","in","comparison","with","that","of","1","alpha",",","25-dihydroxyvitamin","D3","(","VD3",")","a","typical","inducer","of","monocytic","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1207","tokens":["The","C-terminus","of","the","B","cell","activator","Oct-2","functions","as","an","activation","domain","in","yeast","."],"ner_tags":[0,9,0,0,9,10,10,9,0,0,0,9,10,0,0,0]}
{"id":"1811","tokens":["In","order","to","delineate","the","tissue-specific","mechanisms","governing","the","control","of","nonpituitary","PRL","gene","expression",",","we","have","cloned","and","sequenced","3","kb","5'-flanking","DNA","of","the","upstream","decidual\/lymphoid","(","dPRL",")","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,1,2,2,2,0,0,0,1,2,2,2,2,0]}
{"id":"18254","tokens":["In","all","cell","lines","investigated",",","the","NF-kappa","B","complexes","induced","following","CD30","engagement","were","shown","to","contain","p50","NF-kappa","B1",",","p65","RelA",",","and","possibly","other","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,9,0,0,0,0,0,9,10,10,0,9,10,0,0,0,0,9,10,0]}
{"id":"7464","tokens":["Due","to","a","switch","from","the","use","of","a","3","'","polyA","site","to","a","more","proximal","polyA","site",",","NF-ATc","expression","switches","from","the","synthesis","of","the","two","longer","isoforms","in","naive","T","cells","to","that","of","short","isoform","A","in","T","effector","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,1,2,2,0,9,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,9,10,0,7,8,8,0]}
{"id":"16683","tokens":["Recombinant","murine","and","human","TCF-1","recognized","the","same","sequence","motif","in","the","CD3-epsilon","enhancer","as","judged","by","gel","retardation","and","methylation","interference","assays","."],"ner_tags":[9,10,10,10,10,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"12632","tokens":["Glucocorticoids","are","important","for","maintaining","cellular","and","humoral","homeostasis","and","are","key","mediators","of","neuroendocrine-immune","regulatory","interactions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15021","tokens":["These","genes","encode","proteins","that","form","the","dimeric","complex","activator","protein-1","(","AP-1",")",",","which","is","active","as","a","transcriptional","factor","."],"ner_tags":[0,0,0,0,0,0,0,9,10,9,10,0,9,0,0,0,0,0,0,0,9,10,0]}
{"id":"15006","tokens":["TPA","induction","inhibits","the","binding","of","the","lineage","limited","transcription","factor","NF-E2","to","this","transcriptional","control","element","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,9,0,0,1,2,2,0]}
{"id":"13348","tokens":["Both","cell","lines","are","devoid","of","genetic","lesions","of","c-MYC",",","BCL-2","and","p53","as","well","as","gross","rearrangements","of","BCL-6","."],"ner_tags":[0,5,6,0,0,0,0,0,0,9,0,9,0,9,0,0,0,0,0,0,9,0]}
{"id":"15398","tokens":["Expression","of","M10","did","not","affect","induction","of","HIV","transcription","mediated","by","the","kappa","B","regulatory","element","or","Tat","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,9,0]}
{"id":"1856","tokens":["Inhibition","of","rat","splenocyte","proliferation","with","methylprednisolone",":","in","vivo","effect","of","liposomal","formulation","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18261","tokens":["The","inverse","relation","between","high","density","lipoprotein","(","HDL",")","and","atherosclerotic","events","may","in","part","be","due","to","enzymes","associated","with","HDL","that","destroy","the","biologically","active","lipids","generated","in","LDL","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18208","tokens":["BOB.1\/OBF.1","can","efficiently","activate","octamer-dependent","promoters","in","fibroblasts",";","however",",","it","fails","to","stimulate","octamer-dependent","enhancer","activity","."],"ner_tags":[9,0,0,0,0,0,0,7,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"399","tokens":["Inhibitory","action","of","nm23","proteins","on","induction","of","erythroid","differentiation","of","human","leukemia","cells","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,7,8,8,0]}
{"id":"180","tokens":["IL-13","Induced","the","same","complexes","as","IL-4",",","a","finding","explained","by","our","studies","implicating","IL-4R","as","a","shared","component","of","the","receptors","."],"ner_tags":[9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0]}
{"id":"5764","tokens":["Cotransfection","of","Zta","reduced","Qp","activity","in","reporter","assays","."],"ner_tags":[0,0,9,0,1,0,0,0,0,0]}
{"id":"9362","tokens":["With","the","use","of","immunohistochemistry",",","bcl-6","protein","was","shown","to","stain","intensely","on","normal","prickle","cells",",","but","none","to","only","slightly","on","epidermal","basal","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"8134","tokens":["Relative","expressions","of","SERCA","2","and","3","isoforms","and","Ras-related","protein","(","Rap",")","1","in","platelet","membranes","were","determined","by","Western","immunoblots","."],"ner_tags":[0,0,0,9,0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"14254","tokens":["Involvement","of","Alu","sequences","in","the","cell-specific","regulation","of","transcription","of","the","gamma","chain","of","Fc","and","T","cell","receptors","."],"ner_tags":[0,0,1,2,0,0,0,0,0,0,0,0,9,10,0,9,0,9,10,10,0]}
{"id":"3685","tokens":["To","examine","the","molecular","basis","of","constitutive","NF-kappaB","DNA-binding","activity","in","HIV1","-infected","cells",",","we","analyzed","the","phosphorylation","and","turnover","of","IkappaBalpha","protein",",","the","activity","of","the","double-stranded","RNA-dependent","protein","kinase","(","PKR",")","and","the","intracellular","levels","of","NF-kappaB","subunits","in","the","PLB-985","and","U937","myeloid","cell","models","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,7,8,8,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,10,10,0,9,0,0,0,0,0,0,9,10,0,0,5,0,5,6,6,6,0]}
{"id":"12600","tokens":["The","anaphylatoxins","C5a","and","C3a","are","involved","in","the","regulation","of","cytokine","production","."],"ner_tags":[0,9,9,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"768","tokens":["In","this","study",",","we","show","that","Tat-","HIV-1","with","wild-type","LTRs","can","replicate","in","HeLa","cells",",","and","the","virus","produced","from","HeLa","cells","can","infect","primary","peripheral","blood","lymphocytes","and","macrophages","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,5,6,0,0,0,0,0,0,5,6,0,0,0,7,8,8,0,7,0]}
{"id":"3398","tokens":["Although","NF-kappa","B","activates","the","expression","of","many","genes","involved","in","immune","and","inflammatory","responses",",","little","is","known","about","the","role","of","NF-kappa","B","activation","in","the","induction","of","IgE","synthesis","in","human","B","cells","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"11904","tokens":["Such","differentiation","block","by","AML1a","was","canceled","by","the","concomitant","overexpression","of","AML1b","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"9164","tokens":["Phenylarsine","oxide","(","PAO",")",",","which","is","described","as","an","inhibitor","of","tyrosine","phosphatase","activity",",","inhibits","H2O2","release","from","human","peripheral","blood","mononuclear","cells","(","PBMCs",")","as","measured","by","electrochemistry","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,7,8,8,8,8,0,7,0,0,0,0,0,0]}
{"id":"16830","tokens":["Paramyxovirus","infection","induced","a","5-","to","10-fold","increase","in","the","steady-state","level","of","TNF-alpha","RNA","in","U9-IIIB","cells","compared","with","U937","cells",",","suggesting","that","HIV-infected","monocytic","cells","produced","higher","levels","of","TNF-alpha","than","did","normal","cells","after","a","secondary","virus","infection","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,5,6,0,0,5,6,0,0,0,5,6,6,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"8513","tokens":["Finally",",","oxidants","are","believed","to","promote","intestinal","epithelial","cell","apoptosis",",","and","the","B-cell","lymphoma\/leukemia-2","gene","product","is","believed","to","inhibit","this","phenomenon","in","an","antioxidant-dependent","manner","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17407","tokens":["The","actions","of","cyclosporin","A","and","FK506","suggest","a","novel","step","in","the","activation","of","T","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"10740","tokens":["We","utilized","THP-1","cells","to","examine","the","response","to","1",",","25","(","OH",")","2D3","with","macrophage","activation","."],"ner_tags":[0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6769","tokens":["CONCLUSION",":","These","findings","suggest","that","the","chemokine","pathways","are","modulated","by","DEP-PAHs","at","the","transcriptional","level",",","reinforcing","the","idea","that","the","development","of","inflammatory","reactions","might","be","affected","by","diesel","exhaust","emission","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"494","tokens":["33","of","them","had","ovulation","and","9","developed","a","LUF","syndrome",",","constituting","two","biological","models","of","an","opposite","situation","for","the","three","markers","observed","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1655","tokens":["In","addition",",","several","novel","KRAB-containing","zinc","finger","genes","and","a","novel","conserved","sequence","element","were","identified","."],"ner_tags":[0,0,0,0,0,1,2,2,2,0,0,0,1,2,2,0,0,0]}
{"id":"14720","tokens":["However",",","other","X1","box-specific","activities","were","detected","in","all","these","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"11840","tokens":["Parental","as","well","as","transfected","SKW6.4","cells","were","transiently","transfected","with","an","IgH-enhancer-luciferase","construct","."],"ner_tags":[0,0,0,0,0,5,6,0,0,0,0,0,1,2,0]}
{"id":"13401","tokens":["We","show","here","that","at","levels","relevant","to","human","disease",",","production","of","the","human","p75TNF-R","in","transgenic","mice","results","in","a","severe","inflammatory","syndrome","involving","mainly","the","pancreas",",","liver",",","kidney",",","and","lung",",","and","characterized","by","constitutively","increased","NF-kappaB","activity","in","the","peripheral","blood","mononuclear","cell","compartment","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,7,8,8,8,0,0]}
{"id":"10801","tokens":["Despite","this",",","there","are","still","significant","gaps","in","our","understanding","of","this","process","and","its","consequences","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3987","tokens":["Studies","on","unicellular","and","paired","daughter","cell","culture","unequivocally","indicate","that","the","shift","is","mediated","by","modulation","of","the","HPC","differentiation","program","to","the","granulopoietic","pathway","(","rather","than","RA-induced","down-modulation","of","multipotent","\/erythroid\/monocytic","HPC","growth","coupled","with","recruitment","of","granulocytic","HPCs",")","."],"ner_tags":[0,0,5,6,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0]}
{"id":"14289","tokens":["(","ABSTRACT","TRUNCATED","AT","250","WORDS",")"],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"11534","tokens":["Each","subject","group","was","divided","into","two","subgroups","according","to","PBMC","sensitivity","to","prednisolone","in","a","mitogen","assay","procedure",";","i.e.",",","sensitive","(","IC50","<","381","ng\/mL",")","and","resistant","(","IC50",">","381","ng\/mL",")","groups","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7134","tokens":["Although","recognized","as","fundamental","aspects","of","T","lymphocyte","development",",","only","recently","have","the","mechanisms","governing","positive","and","negative","selection","been","examined","at","a","molecular","level","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9279","tokens":["The","modulation","by","anti-LPS","mAbs","of","mCD14","-mediated","LPS","uptake","was","associated","with","inhibition","of","LPS-induced","nuclear","factor-kappaB","(","NF-kappaB",")","translocation","and","TNF-alpha","secretion","in","CHO-CD14","cells","and","monocytes",",","respectively",",","while","mAb","enhancement","of","non-","mCD14","-mediated","LPS","uptake","stimulated","these","activities","."],"ner_tags":[0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,9,0,0,5,6,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"11881","tokens":["We","have","developed","a","novel","assay","to","monitor","the","active",",","GTP-bound","form","of","Rap1","based","on","the","differential","affinity","of","Rap1GTP","and","Rap1GDP","for","the","Rap","binding","domain","of","RalGDS","(","RBD",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,9,0,9,0,0,9,10,10,0,9,0,9,0,0]}
{"id":"7739","tokens":["Our","results","suggest","that","activation","of","NF-kappaB","occurs","through","a","Tax","-independent","mechanism","in","leukemic","cells","of","ATL","patients",",","possibly","due","to","differential","NF-kappaB","subunit","activation","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,9,0,0,0,7,8,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"6332","tokens":["Notably",",","the","nuclei","of","reactive","CD3+\/CD4+","T","cells","nearby","to","and","rosetting","around","L","&","H","cells","in","NLPHD","were","also","strongly","BCL-6","+",",","but","lacked","CD40","ligand","(","CD40L",")","expression","."],"ner_tags":[0,0,0,0,0,7,8,8,8,0,0,0,0,0,7,8,8,8,0,0,0,0,0,9,0,0,0,0,9,10,0,9,0,0,0]}
{"id":"18159","tokens":["As","we","observed","that","activated","endothelial","cells","also","expressed","NFAT",",","we","tested","the","antiinflammatory","properties","of","CsA","in","endothelial","cells","."],"ner_tags":[0,0,0,0,7,8,8,0,0,9,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"14293","tokens":["By","contrast",",","memory","cells",",","either","in","vitro","activated","helper","T","cells","reverting","to","a","resting","state",",","or","CD4+","T","(","memory",")","clones",",","or","CD4+CD45RO+","T","cells","isolated","ex","vivo",",","no","longer","have","a","silencer","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,6,0,0,0,0,0,0,0,5,6,6,6,6,6,0,0,5,6,6,0,0,0,0,0,0,0,0,1,0]}
{"id":"6293","tokens":["These","results","demonstrate","physical","and","functional","interactions","between","AML1","and","BSAP","and","suggest","that","AML1","is","an","important","factor","for","regulating","a","critical","B","cell-specific","gene",",","blk","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,9,0,0,0,0,0,0,0,0,1,2,2,0,1,0]}
{"id":"17016","tokens":["The","Epstein-Barr","virus","(","EBV",")","ORI1yt","enhancer","is","not","B-cell","specific","and","does","not","respond","synergistically","to","the","EBV","transcription","factors","R","and","Z","."],"ner_tags":[0,1,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"12785","tokens":["To","address","this","issue",",","we","have","investigated","IL-12","expression","in","B","cells","during","in","vitro","transformation","with","EBV","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"21","tokens":["The","inability","of","E1A","gene","products","to","induce","cytolytic","susceptibility","during","infection","was","not","explained","by","an","inhibitory","effect","of","viral","infection","on","otherwise","susceptible","target","cells","or","by","viral","gene","effects","on","class","I","MHC","antigen","expression","on","target","cells","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,1,2,0,0,9,10,10,10,0,0,7,8,0]}
{"id":"5912","tokens":["Copyright","1999","Academic","Press","."],"ner_tags":[0,0,0,0,0]}
{"id":"1015","tokens":["The","receptor","was","tested","immunocytochemically",",","in","steroid","binding","assays",",","and","by","a","mutation","screening","(","denaturing","gradient","gel","electrophoresis",")","of","the","receptor-cDNA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"16751","tokens":["Stimulation","of","interferon","beta","gene","transcription","in","vitro","by","purified","NF-kappa","B","and","a","novel","TH","protein","."],"ner_tags":[0,0,1,2,2,0,0,0,0,0,9,10,0,0,0,9,10,0]}
{"id":"14177","tokens":["We","further","characterize","which","AP1","family","members","can","assume","this","role","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"3601","tokens":["Activated","viral","gene","expression","associated","with","phenotypic","conversion","of","group","I","cell","lines","in","to","group","II","or","III","restores","the","Egr-1","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,5,6,0,5,0,0,1,2,0,0]}
{"id":"157","tokens":["The","protein","products","of","this","gene","contain","the","basic-helix-loop-helix","motif","characteristic","of","a","large","family","of","transcription","factors","that","bind","to","the","canonical","DNA","sequence","CANNTG","as","protein","heterodimers","."],"ner_tags":[0,9,10,0,0,0,0,0,9,10,0,0,0,0,0,0,9,10,0,0,0,0,1,2,2,2,0,9,10,0]}
{"id":"14421","tokens":["Association","with","the","precursors","is","sufficient","for","cytoplasmic","retention","of","either","p65","or","c-Rel",",","both","of","which","are","otherwise","nuclear","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0]}
{"id":"14508","tokens":["The","data","also","indicate","that","CD2","receptor","activation","and","phytohemagglutinin","plus","phorbol","12-myristate","13-acetate","stimulation","augment","T","cell","IL3","gene","expression","through","the","same","cis-","and","trans-activating","signals","."],"ner_tags":[0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"10510","tokens":["Succinate","alone","had","no","effect","."],"ner_tags":[0,0,0,0,0,0]}
{"id":"15002","tokens":["Suppression","of","a","cellular","differentiation","program","by","phorbol","esters","coincides","with","inhibition","of","binding","of","a","cell-specific","transcription","factor","(","NF-E2",")","to","an","enhancer","element","required","for","expression","of","an","erythroid-specific","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,1,2,0,0,0,0,0,1,2,0]}
{"id":"11859","tokens":["We","have","also","observed","a","differential","expression","of","the","NF-YA","subunit","in","heme-treated","and","control","FLCs","and","during","monocyte-to-macrophage","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,5,0,0,0,0,0]}
{"id":"13194","tokens":["Activation","of","NFkappaB","in","peripheral","blood","T","cells","was","inducible","during","cytokine","therapy","in","four","of","six","individuals","who","displayed","impaired","NFkappaB","activity","prior","to","therapy","."],"ner_tags":[0,0,9,0,7,8,8,8,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"15271","tokens":["Treatment","of","SKW","6.4","cells","with","IL","6","induced","a","transient","and","early","stimulation","of","c-fos","sense","mRNA","expression","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,3,4,4,0,0]}
{"id":"18214","tokens":["The","dephosphorylated","form","of","Ets-1","has","been","shown","to","bind","to","chromatin",",","suggesting","that","the","operative","kinase","should","be","detectable","in","the","nucleus","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"4539","tokens":["This","activity","is","further","inducible","in","activated","T","cells",",","but","not","in","fibroblasts","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,7,0]}
{"id":"1164","tokens":["CONCLUSIONS",":","In","the","present","work",",","we","show","that","human","fetal","and","adult","erythroid","progenitors","are","distinct","in","their","transcription","factors",",","and","that","the","commitment","to","fetal","or","adult","program","occurs","at","a","very","early","differentiation","stage","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,8,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9694","tokens":["Analysis","of","DNA","failed","to","show","genomic","rearrangements","corresponding","to","transcripts","containing","deletions","in","the","same","samples","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10395","tokens":["Electrophoretic","mobility","shift","assays","demonstrated","a","strong","increase","of","NF-kappa","B","DNA","binding","after","triggering","of","HLA-DR","antigens","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,0]}
{"id":"8902","tokens":["Previous","studies","have","shown","that","binding","to","cell-surface","heparan","sulphate","is","essential","for","optimal","activity","of","IFN-gamma","and","that","free","heparin","competitively","inhibits","this","sequestration","process","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"3090","tokens":["The","data","demonstrate","that","the","p65","subunit","of","NF-kappa","B","is","inhibited","by","salicylate","treatment","and","highlight","the","role","of","salicylate","in","the","control","of","gene","expression","of","inflammatory","mediators","."],"ner_tags":[0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"1576","tokens":["We","also","assayed","the","levels","of","transcription","factor","AP-1","and","demonstrated","that","it","was","constitutively","present","in","increased","amounts","in","Theileria-infected","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,9,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"1876","tokens":["Again",",","in","vitro","supershift","studies","indicate","that","the","presence","of","p50",",","p52",",","p65",",","and","cRel","correlates","with","positive","function","whereas","the","presence","of","only","p50","and","p52","correlates","with","negative","function","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,9,0,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"2172","tokens":["In","contrast","to","PMA",",","RA","did","not","induce","any","CAT","activity","in","these","cells",",","thus","suggesting","that","the","RA-induced","changes","in","the","expression","of","those","genes","described","above","were","not","dependent","on","the","AP-1","enhancer","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"3711","tokens":["The","ATRA-induced","expression","of","IRF-1",",","an","activator","of","transcription","and","repressor","of","transformation",",","may","be","one","of","the","molecular","mechanisms","of","ATRA-induced","growth","inhibition",",","and","the","basis","for","the","synergistic","actions","of","ATRA","and","IFNs","in","myeloid","leukemia","cells","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,5,6,6,0]}
{"id":"5727","tokens":["Loss","of","both","cytolytic","susceptibility","and","sensitization","to","chemically","induced","apoptosis","was","coselected","during","in","vivo","selection","of","E1A-positive","sarcoma","cells","for","increased","tumorigenicity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0]}
{"id":"868","tokens":["In","addition",",","this","TR2RE-SV40","can","function","as","a","repressor","to","suppress","the","transcriptional","activities","of","both","SV40","early","and","late","promoters","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0]}
{"id":"12353","tokens":["To","determine","the","mechanisms","responsible","for","these","differences",",","we","turned","to","human","U937","promonocytic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"17009","tokens":["Immunostained","tumor","cells","were","more","frequently","distributed","in","the","area","where","tumor","cell","infiltration","was","more","invasive","."],"ner_tags":[7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13973","tokens":["Additionally",",","IL-13","suppresses","IL-2-induced","NK","cytolytic","and","proliferative","activities","although","less","efficiently","than","IL-4","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"3916","tokens":["Lymphocytes","from","CML","patients","lack","a","47","kDa","factor","having","affinity","for","a","genomic","sterol","regulatory","sequence","."],"ner_tags":[7,0,0,0,0,0,9,10,10,0,0,0,0,1,2,2,2,0]}
{"id":"10306","tokens":["Certain","subpopulations","of","lymphocytes","synthesize","and","secrete","biologically","active","prolactin",",","which","suggests","that","prolactin","can","act","as","an","autocrine","and\/or","paracrine","factor","to","modulate","the","activities","of","cells","of","the","immune","system","."],"ner_tags":[0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15939","tokens":["The","effect","of","constitutive","Tax","expression","on","the","interaction","of","NF-kappa","B","with","its","recognition","sequence","and","on","NF-kappa","B","-dependent","gene","expression","was","examined","in","T","lymphoid","Jurkat","cell","lines","(","19D","and","9J",")","stably","transformed","with","a","Tax","expression","vector","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,10,0,0,1,2,0,0,9,10,0,0,0,0,0,0,5,6,6,6,6,0,5,0,5,0,0,0,0,0,1,2,2,0]}
{"id":"1484","tokens":["These","results","indicate","that","NS-Meg","cells","undergo","terminal","differentiation","of","both","megakaryocytic","and","erythroid","lineages","."],"ner_tags":[0,0,0,0,5,6,0,0,0,0,0,7,8,8,8,0]}
{"id":"2841","tokens":["Sterol","regulatory","element","(","SRE",")","has","been","recognized","to","regulate","various","key","genes","coding","for","especially","low","density","lipoprotein","(","LDL",")","-receptor",",","3-hydroxy-3-methylglutaryl","coenzyme","A","(","HMG-CoA",")","reductase","and","HMG-CoA","synthase","known","to","play","a","crucial","role","in","the","cholesterol","feedback","mechanism","."],"ner_tags":[1,2,2,0,1,0,0,0,0,0,0,0,0,1,0,0,0,9,10,10,10,10,10,10,0,9,10,10,10,10,10,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8102","tokens":["Regulation","of","the","megakaryocytic","glycoprotein","IX","promoter","by","the","oncogenic","Ets","transcription","factor","Fli-1","."],"ner_tags":[0,0,0,1,2,2,2,0,0,9,10,10,10,9,0]}
{"id":"372","tokens":["Sp1","functions","in","a","chromatin","-dependent","manner","to","augment","human","alpha-globin","promoter","activity","."],"ner_tags":[9,0,0,0,1,0,0,0,0,1,2,2,0,0]}
{"id":"1298","tokens":["p50.c-rel","heterodimers","were","also","detected","bound","to","this","sequence","at","early","time","points","(","7-16","h",";","early",")",",","and","both","remained","active","at","later","time","points","(","40","h",";","late",")","after","activation","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9837","tokens":["In","this","study","we","examined","the","basis","of","activation","of","monocytes","during","active","tuberculosis","and","by","M.","tuberculosis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0]}
{"id":"2802","tokens":["Previous","analyses","of","immunoglobulin","V","region","promoters","has","led","to","the","discovery","of","a","common","octamer","motif","which","is","functionally","important","in","the","tissue-specific","and","developmentally","regulated","transcriptional","activation","of","immunoglobulin","genes","."],"ner_tags":[0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"12331","tokens":["These","mediators","were","measured","in","supernatants","from","ventilated","alveolar","macrophages",",","monocyte-derived","macrophages",",","and","promonocytic","THP-1","cells","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,0,7,8,0,0,5,6,6,0]}
{"id":"11708","tokens":["Using","this","assay",",","we","also","showed","that","Pax-5d","was","present","in","nuclear","extracts","of","some","(","but","not","all",")","B-lymphoid","lines","and","interacts","with","the","B-cell-specific","activator","protein-binding","site","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,1,2,2,2,0]}
{"id":"7171","tokens":["As2O3","induced","PML","(","promyelocytic","leukemia",")","protein","degradation","but","did","not","modulate","expression","of","cell","cycle-related","proteins",",","including","c-myc",",","retinoblastoma","protein",",","cyclin-dependent","kinase","4",",","cyclin","D1",",","and","p53",",","or","expression","of","differentiation-related","antigens","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,0,9,10,0,9,10,10,0,9,10,0,0,9,0,0,0,0,9,10,0]}
{"id":"2201","tokens":["The","HB9","gene","is","composed","of","3","exons","spread","over","6","kilobases","of","DNA","."],"ner_tags":[0,1,2,0,0,0,0,1,0,0,0,0,0,0,0]}
{"id":"8101","tokens":["These","results","support","our","hypothesis","that","HCMV","initiates","a","signal","transduction","pathway","that","leads","to","monocyte","activation","and","pinpoints","a","potential","mechanism","whereby","HCMV","infection","of","monocytes","can","result","in","profound","pathogenesis",",","especially","in","chronic","inflammatory-type","conditions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10998","tokens":["Co-stimulation","of","microglia","with","suboptimal","concentrations","of","A","beta","(","25-35",")","and","100","U\/ml","IFN","gamma","resulted","in","the","detection","of","a","specific","NF-kappa","B","DNA-binding","activity","in","nuclear","extracts",",","as","determined","in","gel","mobility","shift","assays","."],"ner_tags":[0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16162","tokens":["A","factor","with","apparently","indistinguishable","sequence","specificity","can","be","induced","in","many","other","cell","types",",","where","it","is","used","to","regulate","inducible","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4160","tokens":["These","data","suggest","that","in","activated","normal","T","cells",",","CD28","-derived","signals","can","stimulate","proliferation","at","least","in","part","via","NF-kappaB","and","AP-1","generation",",","and","that","this","response","uses","both","acidic","sphingomyelinase","and","phosphatidylinositol","3-kinase","-linked","pathways","."],"ner_tags":[0,0,0,0,0,0,7,8,8,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,0,0]}
{"id":"2363","tokens":["In","gel","retardation","analysis",",","FK506","had","little","effect","on","the","binding","to","the","AP-1","site","of","PMA\/ionomycin-induced","nuclear","factors",",","which","were","recognized","with","anti-JunD","or","c-Fos","antibody","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,9,0,9,10,0]}
{"id":"14401","tokens":["We","have","previously","reported","that","the","T","lymphocytes","of","a","child","with","severe","combined","immunodeficiency","are","defective","in","the","transcription","of","several","lymphokine","genes","that","include","IL2",",","IL3",",","IL4",",","and","IL5",",","which","encode","interleukins","2",",","3",",","4",",","and","5","(","IL-2",",","-3",",","-4",",","and","-5",")","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,1,0,1,0,1,0,0,1,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,9,0,0,9,0,0]}
{"id":"17791","tokens":["Thus",",","intact","microtubules","are","essential","for","1",",","25","(","OH",")","2D3-dependent","modulation","of","gene","transcription","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1919","tokens":["Moreover",",","rapamycin",",","an","inhibitor","of","pp70S6K","activation",",","had","no","effect","on","induction","of","EGR-1","expression","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,1,0,0]}
{"id":"12789","tokens":["These","results","suggest","that","transformation","of","primary","B","cells","with","EBV","induces","IL-12","expression","potentially","through","LMP1","expression","."],"ner_tags":[0,0,0,0,0,0,7,8,8,0,0,0,9,0,0,0,9,0,0]}
{"id":"275","tokens":["The","mechanism","of","overexpression","in","various","tumor","cell","types","and","its","biological","significance","in","cutaneous","carcinogenesis","remain","to","be","determined","."],"ner_tags":[0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8854","tokens":["Its","effects","are","exerted","by","interaction","with","the","vitamin","D","receptor",",","which","is","present","on","human","monocytes","and","activated","T","and","B","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,7,8,0,7,8,8,8,8,0]}
{"id":"8686","tokens":["Accessing","Epstein-Barr","virus-specific","T-cell","memory","with","peptide-loaded","dendritic","cells","."],"ner_tags":[0,0,0,0,0,0,5,6,6,0]}
{"id":"697","tokens":["We","have","previously","found","a","high","expression","of","human","Ah","receptor","(","TCDD","receptor",")","mRNA","in","peripheral","blood","cells","of","individuals","."],"ner_tags":[0,0,0,0,0,0,0,0,3,4,4,4,4,4,4,4,0,7,8,8,0,0,0]}
{"id":"5778","tokens":["Suppression","of","the","human","immunodeficiency","virus","long","terminal","repeat","by","CD8+","T","cells","is","dependent","on","the","NFAT-1","element","."],"ner_tags":[0,0,0,1,2,2,2,2,2,0,7,8,8,0,0,0,0,1,2,0]}
{"id":"2381","tokens":["Anti-CD28-stimulated","T","cells","produced","significant","amounts","of","IL-8",";","additionally",",","costimulation","with","anti-CD3","and","anti-CD28","Abs","resulted","in","a","synergistic","induction","of","IL-8","secretion","."],"ner_tags":[5,6,6,0,0,0,0,9,0,0,0,0,0,9,0,9,10,0,0,0,0,0,0,9,0,0]}
{"id":"4079","tokens":["When","single-point","mutation","was","introduced","to","each","GC","box",",","EBS",",","and","GT","box","in","PFP9a20",",","at","least","3-fold","less","CAT","activity","was","observed","in","CTLL-R8","cells","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,1,0,0,1,2,0,1,0,0,0,0,0,9,0,0,0,0,5,6,0]}
{"id":"5116","tokens":["We","conclude","that","a","VDRE-binding","protein","(","s",")",",","distinct","from","IDBP","and","present","in","nuclear","extract","of","cells","from","a","prototypical","vitamin","D-resistant","NWP",",","is","capable","of","inhibiting","normal","VDR-RXR","heterodimer","binding","to","the","VDRE","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,9,0,0,0,0,1,0]}
{"id":"17738","tokens":["RESULTS",":","During","menopause","there","is","a","significant","decrease","in","the","percentage","of","ER","positive","monocytes",",","and","an","increase","in","blood","monocyte","number",",","which","declines","following","estrogen","replacement","therapy","to","values","of","the","young","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12181","tokens":["Bone","marrow","samples","from","33","patients","affected","by","MM","and","MGUS",",","and","8","patients","not","affected","by","lymphoproliferative","diseases","were","studied","for","expression","of","c-Jun","(","a","component","of","the","transcription","factor","AP-1",")","and","glutathione-S-transferase","pi","(","GST-pi",")","using","immunocytochemical","methods","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,9,0,0,9,10,0,9,0,0,0,0,0]}
{"id":"5150","tokens":["Although","a","role","of","p16","in","this","regulation","has","been","presumed",",","there","is","no","proof","so","far","that","loss","of","this","tumor","suppressor","gene","really","affects","E2F","-mediated","regulations","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,9,0,0,0]}
{"id":"5899","tokens":["These","data","demonstrate","that","intracellular","free","calcium","and","the","calcium-dependent","protease",",","calpain","play","critical","roles","in","monocytic","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0]}
{"id":"17437","tokens":["The","erythroid","transcription","factor","erythroid","factor-1","(","EF1",")","plays","a","critical","role","in","the","transcription","of","erythroid-specific","genes","."],"ner_tags":[0,9,10,10,9,10,0,9,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"11142","tokens":["Inhibition","of","TNF-alpha","production","by","THP-1-hGH-transfected","cells","cultured","in","the","presence","of","LPS","is","dependent","on","a","selective","pathway",",","since","no","inhibition","of","TNF-alpha","production","was","observed","when","cells","were","cultured","in","the","presence","of","PMA","."],"ner_tags":[0,0,9,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9998","tokens":["5.","One","of","the","signaling","molecules","which","mediates","programmed","cell","death","is","nuclear","factor","Kappa-B","(","NF-kappa","B",")","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,9,10,10,0,9,10,0,0]}
{"id":"11949","tokens":["A","1.2-kb","cDNA","encoding","full-length","human","C\/EBP-epsilon","was","cloned","from","a","promyelocyte-late","myeloblast-derived","lambda","gt11","library","."],"ner_tags":[0,1,2,0,0,1,2,0,0,0,0,1,2,2,2,2,0]}
{"id":"7810","tokens":["We","report","here","the","cleavage","of","the","transcription","factor","SP1","in","the","human","Burkitt","lymphoma","cell","line","BL60","during","anti-IgM","-induced","apoptosis","."],"ner_tags":[0,0,0,0,0,0,0,9,10,9,0,0,5,6,6,6,6,6,0,9,0,0,0]}
{"id":"13352","tokens":["Two-site","interaction","of","nuclear","factor","of","activated","T","cells","with","activated","calcineurin","."],"ner_tags":[0,0,0,9,10,10,10,10,10,0,0,9,0]}
{"id":"9826","tokens":["Like","ML-1a",",","human","dermal","microvessel","endothelial","cells","(","MVEC",")","treated","with","TNF","rapidly","activated","(","within","30","min",")","NF-kappa","B",";","this","effect","was","completely","abolished","by","co-treatment","with","phenylarsine","oxide","(","PAO",")",",","a","specific","inhibitor","of","PTPase","."],"ner_tags":[0,5,0,5,6,6,6,6,0,5,0,0,0,9,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"8398","tokens":["We","present","a","model","in","which","HMG-I","(","Y",")","alters","DNA","conformation","to","allow","binding","of","repressor","proteins",",","and","in","which","the","relative","amount","of","HMG-I","(","Y",")","helps","to","determine","the","repressive","state","of","the","beta-globin","gene","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"14224","tokens":["Regulation","of","the","beta-globin","locus","."],"ner_tags":[0,0,0,1,2,0]}
{"id":"3119","tokens":["The","active","enzyme","was","expressed","in","Escherichia","coli","and","in","insect","cells","as","a","non-fusion","protein","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,9,10,0]}
{"id":"9895","tokens":["Despite","stimulation","with","LPS",",","disruption","of","the","NF-kappaB","signaling","pathway","in","precursor","B","cells","led","to","the","loss","of","inducible","Oct-2","DNA","binding","activity","in","vitro","and","the","suppression","of","Oct-2","-directed","transcription","in","vivo","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,7,8,8,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"13593","tokens":["We","report","here","that","phosphatidylinositol","(","PtdIns",")",",","phosphatidylinositol-4-phosphate",",","and","other","phosphatidylinositides","can","bind","to","mCD14","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"7165","tokens":["Mitochondrial","transmembrane","potential","(","delta","psi","(","m",")",")","was","measured","by","means","of","rhodamine","123","staining","and","flow","cytometry","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9238","tokens":["Bipotential","T\/natural","killer","(","NK",")","progenitor","cells","are","present","in","the","human","thymus","."],"ner_tags":[7,8,8,8,8,8,8,8,0,0,0,0,0,0,0]}
{"id":"4901","tokens":["Newly","translated","STAT1","binds","in","equilibrium","fashion","to","STAT2","and","STAT3",",","but","we","show","that","STAT2","and","STAT3","exist","in","separate","heterocomplexes","with","STAT1",",","consistent","with","a","model","in","which","STAT1","contains","a","common","binding","site","for","other","STAT","proteins","."],"ner_tags":[0,0,9,0,0,0,0,0,9,0,9,0,0,0,0,0,9,0,9,0,0,0,9,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0]}
{"id":"13864","tokens":["We","examined","signaling","by","erythropoietin","in","highly","purified","human","colony","forming","unit-erythroid","cells",",","generated","in","vitro","from","CD34","(","+",")","cells","."],"ner_tags":[0,0,0,0,9,0,7,8,8,8,8,8,8,0,0,0,0,0,7,8,8,8,8,0]}
{"id":"7861","tokens":["These","findings","may","provide","clues","toward","understanding","the","involvement","of","cAMP","signaling","in","the","pathogenesis","of","bipolar","disorder","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15527","tokens":["Therefore",",","we","describe","a","microtitre","assay","system","for","glucocorticoid","receptors","which","is","a","whole-cell","competitive","binding","radioassay","using","[","3H","]","-dexamethasone","as","radioligand","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4968","tokens":["Transient-transfection","experiments","demonstrated","that","plasmids","containing","446","bp","of","c-fes","5'-flanking","sequences","linked","to","a","luciferase","reporter","gene","were","active","exclusively","in","myeloid","cells","."],"ner_tags":[0,0,0,0,1,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"8789","tokens":["In","a","sample","from","one","of","the","patients",",","c-fos-positive","lymphocytes","were","identified","as","CD4","positive","and","CD8","negative","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"14938","tokens":["The","promoter","of","the","TP1","gene","was","chosen","as","a","model","system","to","study","the","molecular","mechanism","of","EBNA2","mediated","transactivation","."],"ner_tags":[0,1,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"10053","tokens":["Thus","we","hypothesized","that","combinations","of","hypoxia","and","inflammatory","stimuli","may","differentially","regulate","expression","of","endothelial","ICAM-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"6369","tokens":["Glucocorticoids","induce","apoptosis","in","human","monocytes",":","potential","role","of","IL-1","beta","."],"ner_tags":[0,0,0,0,7,8,0,0,0,0,9,10,0]}
{"id":"9063","tokens":["IL-10","treatment","prevented","the","downregulation","of","p27","(","Kip1",")",",","an","inhibitory","protein","that","controls","progression","out","of","the","G0","phase","of","the","cell","cycle","."],"ner_tags":[9,0,0,0,0,0,9,10,10,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6336","tokens":["The","eukaryotic","transcription","factor","NF-kappa","B","is","involved","in","the","inducible","expression","of","various","inflammatory","genes","as","well","as","in","HIV-1","replication","."],"ner_tags":[0,9,10,10,10,10,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0]}
{"id":"8627","tokens":["These","results","provide","evidence","for","a","strong","genetic","component","of","male","breast","cancer","in","Hungary","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4785","tokens":["In","humans","infected","with","the","HIV-1","virus","there","may","be","a","disproportionate","severity","of","signs","and","symptoms","of","illness","compared","to","the","fraction","of","CD4+","infected","T-lymphoid","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"7983","tokens":["Specificity","of","ANG","II","-induced","NF-kappaB","activation","was","ascertained","by","supershift","and","competition","experiments","."],"ner_tags":[0,0,9,10,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"4648","tokens":["A","stable","transformant","of","the","PLAP","reporter","gene","derived","from","human","monocytic","cell","line","showed","very","little","activity","on","the","promoter","before","stimulation",",","whereas","LPS","stimulation","led","to","a","dramatic","increase","in","PLAP","activity","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"355","tokens":["BACKGROUND",":","The","induction","of","vascular","cell","adhesion","molecule-1","(","VCAM-1",")","and","E-selectin","by","tumor","necrosis","factor-alpha","(","TNF",")","is","mediated","by","mobilization","of","the","transcription","factor","nuclear","factor-kappa","B","(","NF-kappa","B",")","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,9,0,0,9,0,9,10,10,0,9,0,0,0,0,0,0,0,9,10,9,10,10,0,9,10,0,0]}
{"id":"3554","tokens":["Second",",","T","cells",",","which","lack","CD45","and","can","not","signal","via","the","TCR",",","supported","higher","levels","of","viral","replication","and","gene","expression","."],"ner_tags":[0,0,7,8,0,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12121","tokens":["No","correlation","was","seen","between","VDR","and","serum","calcitriol","or","PTH","levels",",","when","considering","both","groups","of","patients","together","or","separately","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6530","tokens":["Glucocorticoid","(","GC",")","-insensitive","asthma","is","a","challenging","clinical","problem","that","can","be","associated","with","life-threatening","disease","progression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12264","tokens":["70Z\/3",",","but","not","Cbl",",","caused","NFAT","activation","which","was","significantly","enhanced","by","stimulation","with","calcium","ionophore",",","and","was","drastically","reduced","by","cyclosporin","A","pretreatment","."],"ner_tags":[9,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13872","tokens":["Oxidative","stress","suppresses","transcription","factor","activities","in","stimulated","lymphocytes","."],"ner_tags":[0,0,0,9,10,0,0,7,8,0]}
{"id":"828","tokens":["CBF","consists","of","two","subunits",",","a","DNA","binding","subunit",",","CBF","alpha",",","and","a","second","subunit",",","CBF","beta",",","that","stimulates","the","DNA","binding","activity","of","CBF","alpha","."],"ner_tags":[9,0,0,0,0,0,0,9,10,10,0,9,10,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8089","tokens":["(","4",")","Intrafollicular","CD57+","cells","were","negative","for","Bcl-6",",","indicating","heterogeneity","of","the","intrafollicular","T-cell","population","."],"ner_tags":[0,0,0,7,8,8,0,0,0,9,0,0,0,0,0,7,8,8,0]}
{"id":"17952","tokens":["Intravenous","injection","of","a","rat","T-cell","line","that","overexpresses","L-selectin","showed","increased","organ","infiltration","."],"ner_tags":[0,0,0,0,5,6,6,0,0,9,0,0,0,0,0]}
{"id":"10844","tokens":["Patients","with","one","type","of","major","histocompatibility","complex","class","II","combined","immunodeficiency","have","mutations","in","a","gene","termed","class","II","transactivator","(","CIITA",")",",","which","coordinately","controls","the","transcription","of","the","three","major","human","class","II","genes",",","HLA-DR",",","-DQ",",","and","-DP","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,1,2,2,2,2,2,0]}
{"id":"15337","tokens":["The","increase","in","AP-1","-binding","activity","was","accompanied","by","the","marked","stimulation","of","the","transcription","of","c-fos","but","not","that","of","c-jun","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0]}
{"id":"2408","tokens":["We","have","studied","the","regulation","of","corticosteroid","receptors","in","human","mononuclear","leukocytes","as","a","possible","marker","of","brain","involution","."],"ner_tags":[0,0,0,0,0,0,9,10,0,7,8,8,0,0,0,0,0,0,0,0]}
{"id":"15594","tokens":["The","insertion","was","not","required","for","Fc","gamma","RII","to","modulate","surface","immunoglobulin","-triggered","B-cell","activation","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,9,10,0,0,0,0]}
{"id":"4555","tokens":["Substantial","decreases","of","IL-2","production","were","observed","for","cell","cultures","from","7","of","12","elderly","individuals","in","response","to","the","different","stimuli",",","whereas","the","levels","of","IL-2","produced","by","stimulated","T","cells","from","other","elderly","individuals","were","equivalent","to","those","observed","for","stimulated","T","cells","of","young","subjects","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11555","tokens":["Infection","of","human","peripheral","blood","lymphocytes","with","HIV-1","in","vitro","resulted","in","increased","interleukin-2","(","IL-2",")","secretion","in","response","to","T","cell","activation","via","the","CD3","and","CD28","receptors","."],"ner_tags":[0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"11305","tokens":["The","function","of","LEF-1","is","dependent",",","in","part",",","on","the","HMG","domain","that","induces","a","sharp","bend","in","the","DNA","helix",",","and","on","an","activation","domain","that","stimulates","transcription","only","in","a","specific","context","of","other","enhancer-binding","proteins","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"17236","tokens":["Accordingly",",","the","same","set","of","words","and","phrases","(","oligopeptides",")","appear","in","totally","unrelated","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8324","tokens":["Thus","HIV-1","gp41","-induced","IL-10","up-regulation","in","monocytes","may","not","involve","NF-kappaB",",","MAPK",",","or","PI","3-kinase","activation",",","but","rather","may","operate","through","activation","of","adenylate","cyclase","and","pertussis-toxin-sensitive","Gi\/Go","protein","to","effect","p70","(","S6",")","-kinase","activation","."],"ner_tags":[0,0,9,0,9,0,0,7,0,0,0,9,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,0,9,10,10,0,0,9,10,10,10,10,0,0]}
{"id":"16835","tokens":["This","level","of","NF-kappa","B","-independent","activity","appears","to","be","sufficient","for","virus","multiplication",",","since","TNF-alpha","treatment","had","no","effect","on","the","kinetics","of","de","novo","HIV","type","1","(","HIV-1",")","infection","and","viral","RNA","production","in","U937","cells","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,5,6,0]}
{"id":"8969","tokens":["TNF","stimulated","expression","of","both","intercellular","adhesion","molecule-1","and","E-selectin","in","HUVECs",",","but","in","HUAECs",",","only","intercellular","adhesion","molecule-1","was","increased","."],"ner_tags":[9,0,0,0,0,9,10,10,0,9,0,7,0,0,0,7,0,0,9,10,10,0,0,0]}
{"id":"9165","tokens":["Since","human","immunodeficiency","virus","type","1","(","HIV-1",")","replication","is","known","to","be","favored","under","oxidative","stress","conditions",",","ex","vivo","experiments","using","uninfected","PBMCs",",","primary","monocytes","or","a","latently","infected","promonocytic","U1","cell","line","show","that","HIV-1","replication","and","reactivation",",","monitored","by","p24","antigen","measurement",",","are","inhibited","by","PAO","in","a","time-","and","concentration-dependent","manner","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,7,8,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17707","tokens":["The","dephosphorylation","of","NFATp","was","accompanied","by","localization","of","the","protein","to","the","nuclear","fraction","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7528","tokens":["Cytokines","that","bind","to","the","common","gamma","chain","of","the","IL-2","receptor","promote","the","survival","of","T","cell","blasts",",","but","also","induce","proliferation","."],"ner_tags":[9,0,0,0,0,0,9,10,0,0,9,0,0,0,0,0,7,8,8,0,0,0,0,0,0]}
{"id":"3100","tokens":["Further","deletional","and","alanine","mutagenesis","analyses","and","comparison","with","TRAF","binding","sequences","in","CD40",",","in","CD30",",","and","in","the","LMP1","of","other","lymphycryptoviruses","provide","the","first","evidence","that","PXQXT\/S","is","a","core","TRAF","binding","motif","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,1,0,0,0,1,2,2,0]}
{"id":"826","tokens":["Core","binding","factor","(","CBF",")",",","also","known","as","polyomavirus","enhancer-binding","protein","2","and","SL3","enhancer","factor","1",",","is","a","mammalian","transcription","factor","that","binds","to","an","element","termed","the","core","within","the","enhancers","of","the","murine","leukemia","virus","family","of","retroviruses","."],"ner_tags":[9,10,10,0,9,0,0,0,0,0,9,10,10,10,0,9,10,10,10,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0]}
{"id":"10294","tokens":["Because","of","the","similar","behaviours","of","aldosterone","and","progesterone",",","we","conclude","that","the","N-terminal","Thr729-Leu765","region","of","the","HBD","is","similarly","involved","in","the","binding","of","both","hormones","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"10404","tokens":["DNase","I","mapping","of","genomic","DNA","identified","a","hypersensitive","element","near","the","transcription","initiation","site","."],"ner_tags":[9,10,0,0,1,2,0,0,1,2,0,0,1,2,2,0]}
{"id":"1516","tokens":["Analysis","of","primary","cells","revealed","substantial","constitutive","NF-kappa","B","-binding","activity","in","blood","monocytes",",","pleural","macrophages","and","alveolar","macrophages","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,7,8,0,7,8,0,7,8,0]}
{"id":"5896","tokens":["These","data","suggest","that","although","MC903","and","KH1060","may","bind","the","VDRnuc",",","that","the","differentiative","activities","of","these","agents","requires","nongenomic","signaling","pathways","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15227","tokens":["Moreover",",","Elf-1","is","the","only","factor","present","in","activated","T-cell","nuclear","extracts","that","binds","to","these","sites","in","electrophoretic","mobility","shift","assays","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1542","tokens":["Engagement","of","the","T","cell","receptor","for","antigen","activates","phospholipase","C","resulting","in","an","increase","in","intracellular","free","calcium","concentration","(","[","Ca2+","]","i",")","and","activation","of","protein","kinase","C","(","PKC",")","."],"ner_tags":[0,0,0,9,10,10,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"13296","tokens":["The","results","show","that","Ras","can","initiate","a","Rac-1","mediated","pathway","that","regulates","the","transcriptional","function","of","AP-1","complexes","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8518","tokens":["Nevertheless",",","none","of","the","genes","originally","thought","to","be","regulated","by","Oct2","were","affected","in","their","expression","in","Oct2-deficient","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,5,6,6,0]}
{"id":"14471","tokens":["However",",","the","specific","members","of","the","NF-kappa","B\/Rel","transcription","factor","family","involved","in","the","LPS","response",",","and","the","mechanisms","through","which","LPS-generated","signals","are","transduced","remain","unclear","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7987","tokens":["Signal","transduction","pathways","activated","in","endothelial","cells","following","infection","with","Chlamydia","pneumoniae","."],"ner_tags":[0,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"212","tokens":["Nuclear","run-on","analysis","revealed","that","the","rate","of","Fc","gamma","RI","transcription","was","increased","by","IFN-gamma","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,9,0]}
{"id":"10008","tokens":["Interestingly",",","the","deduced","amino","acid","sequence","was","found","to","be","related","to","fungal","C8-C7","sterol","isomerase",",","encoded","by","the","ERG2","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,1,2,0]}
{"id":"16902","tokens":["Type-II","estrogen-binding","sites","(","type-II","EBS",")","have","been","demonstrated","in","the","human","lymphoblastoid","cell","line","IM-9","using","a","whole-cell","assay","with","(","6",",","7-3H",")","estradiol","(","3H-E2",")","as","tracer","."],"ner_tags":[9,10,10,0,9,10,0,0,0,0,0,0,5,6,6,6,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12594","tokens":["In","order","to","elucidate","possible","mechanisms","underlying","endothelial","cell","activation","by","xenogeneic","serum",",","we","focussed","on","transcription","factor","NF-kappa","B",",","a","central","regulator","for","the","induction","of","different","genes",",","including","adhesive","molecules","and","chemoattractants","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0]}
{"id":"6816","tokens":["In","contrast","to","these","findings",",","mucosal","hGR","levels","were","significantly","decreased","in","both","steroid-treated","(","18.0","+\/-","15.5",")","and","not","steroid-treated","(","37.8","+\/-","30.5",")","patients","compared","with","control","subjects","(","125.6","+\/-","97.1",";","P","=","0.00009","and","P","=","0.0008","respectively",")","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14365","tokens":["No","such","increase","was","observed","in","control","U937","cells","."],"ner_tags":[0,0,0,0,0,0,0,5,6,0]}
{"id":"16637","tokens":["[","Plasma","cortisol","concentration","and","blood","leukocyte","content","of","glucocorticoid","receptors","in","patients","with","deficiency-cold","vs","deficiency-heat","syndromes","]"],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"6809","tokens":["hGR","levels","were","determined","from","isolated","cytosol","of","peripheral","blood","mononuclear","cells","(","PBMCs",")","or","mucosal","biopsies","using","a","radioassay","with","[","3H","]","-dexamethasone","."],"ner_tags":[9,0,0,0,0,0,0,0,7,8,8,8,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14043","tokens":["The","presence","of","variants","did","not","correlate","with","disease","activity","or","medication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8755","tokens":["GR","number","in","the","patient","'s","transformed","lymphocytes","was","approximately","one","half","that","of","control","cells","with","a","approximately","10-fold","reduction","in","binding","affinity","for","dexamethasone","."],"ner_tags":[0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9978","tokens":["Dimers","encoded","by","HLA-DR","haplotypes","may","be","the","primary","restriction","elements","for","lectin-like",",","gliadin","peptides","while","the","degree","of","immune","suppression","(","or","lack","thereof",")","to","ingested","gliadins","is","governed","by","inherited","HLA-DQ","haplotypes","."],"ner_tags":[0,0,0,9,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]}
{"id":"507","tokens":["These","two","abnormalities","at","the","NF-AT","site","provide","a","potential","mechanism","to","account","for","the","defect","in","IL-2","production","from","Ipr","CD4-8-","T","cells","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,9,0,0,5,6,6,6,0]}
{"id":"7033","tokens":["While","controls","showed","a","moderate","correlation","between","binding","affinity","of","the","GR","in","lymphocytes","and","regulatory","function","at","the","hypothalamic","level",",","the","patients","did","not","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15571","tokens":["Rapid","nongenomic","in","vitro","effects","of","aldosterone","on","intracellular","electrolytes",",","cell","volume",",","and","Na","(","+",")","-H+","antiport","have","been","found","in","human","mononuclear","leukocytes","(","HML",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,7,8,8,0,7,0,0]}
{"id":"3741","tokens":["In","5","patients","the","granulocytes","appeared","polyclonal","and","in","1","patient","unilateral","X","inactivation","was","observed","in","both","granulocytes","and","T","cells","."],"ner_tags":[0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,7,8,0]}
{"id":"11720","tokens":["Activation","of","the","transcription","factor","MEF2C","by","the","MAP","kinase","p38","in","inflammation","."],"ner_tags":[0,0,0,9,10,9,0,0,9,10,10,0,0,0]}
{"id":"17194","tokens":["Southwestern","and","gel","renaturation","experiments","with","the","use","of","purified","protein","fractions","revealed","that","TCF-1","alpha","activity","is","derived","from","a","family","of","57-","to","53-kD","proteins","that","are","abundantly","expressed","in","mature","and","immature","T-cell","lines","(","Jurkat",",","CCRF-CEM",")","and","not","in","mature","B","cells","(","JY",",","Namalwa",")","or","nonlymphoid","(","HeLa",")","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,5,6,6,6,6,0,5,0,5,0,0,0,0,5,6,6,0,5,0,5,0,0,5,6,6,6,6,6,0]}
{"id":"9562","tokens":["In","this","study","we","have","produced","an","antisera","specific","for","STAT3alpha","proteins","phosphorylated","on","serine","727","and","used","this","to","monitor","the","phosphorylation","of","this","residue","during","T","lymphocyte","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12661","tokens":["The","activation","of","this","nuclear","factor","is","qualitatively","different","in","rheumatoid","synovial","T","cells","to","that","in","other","forms","of","non-rheumatoid","arthritis","(","for","example",",","osteoarthritis",",","spondyloarthropathies",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5226","tokens":["Ten","mutants","of","the","simian","immunodeficiency","virus","(","SIV",")","SIVmac239","bearing","deletions","(","delta",")","or","substitutions","(","subst",")","in","the","NF-kappaB","and\/or","Sp1","binding","elements","were","created",",","and","the","replicative","capacities","of","the","mutants","were","analyzed","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14930","tokens":["One","cDNA","clone","of","a","primary","response","gene",",","expressed","upon","macrophage","differentiation",",","encoded","for","Egr-1",",","a","zinc","finger","transcription","factor","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,10,10,0]}
{"id":"18180","tokens":["HIV-1-infected","myeloid","cells","are","often","diminished","in","their","ability","to","participate","in","chemotaxis",",","phagocytosis",",","and","intracellular","killing","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6065","tokens":["Interleukin","10","induced","c-fos","expression","in","human","B","cells","by","activation","of","divergent","protein","kinases","."],"ner_tags":[9,10,0,1,0,0,7,8,8,0,0,0,9,10,10,0]}
{"id":"2224","tokens":["The","present","report","demonstrates","that","even","lower","doses","of","ionizing","radiation",",","0.25-2.0","Gy",",","are","capable","of","inducing","expression","of","NF-kappa","B","in","EBV-transformed","244B","human","lymphoblastoid","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,5,6,6,6,6,0]}
{"id":"14674","tokens":["Enhanced","IL-2","transcription","correlates","with","increased","c-fos","synthesis","and","increased","Fos","content","of","AP-1","."],"ner_tags":[0,9,0,0,0,0,9,0,0,0,9,0,0,9,0]}
{"id":"18187","tokens":["Increased","intracellular","stores","of","latent","NF-kappa","B","may","also","result","in","rapid","inducibility","of","NF-kappa","B","-dependent","cytokine","gene","expression","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0,9,0,0,0]}
{"id":"1672","tokens":["Toxicity","was","measured","by","viability","(","trypan","blue","exclusion",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4074","tokens":["The","six","5","'","upstream","and","one","intronic","DHS","were","detected","in","only","perforin-expressing","lymphocytes","."],"ner_tags":[0,0,1,2,2,0,0,1,2,0,0,0,0,7,8,0]}
{"id":"9266","tokens":["Furthermore",",","this","C\/EBP","epsilon","mRNA","accumulation","did","not","require","synthesis","of","new","protein","factors","because","9-cis","RA","induced","C\/EBP","epsilon","mRNA","accumulation","in","the","absence","of","new","protein","synthesis","."],"ner_tags":[0,0,0,3,4,4,0,0,0,0,0,0,0,9,10,0,0,0,0,3,4,4,0,0,0,0,0,0,0,0,0]}
{"id":"12423","tokens":["CONCLUSIONS",":","These","results","suggest","that","the","alterations","in","the","HPA","axis","and","in","the","cortisol","metabolism","observed","in","PCOS","are","not","related","to","GR","deficiency","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"7376","tokens":["LPS-Induced","NF-kappaB","activation","and","TNF-alpha","release","in","human","monocytes","are","protein","tyrosine","kinase","dependent","and","protein","kinase","C","independent","."],"ner_tags":[0,9,0,0,9,0,0,7,8,0,9,10,10,0,0,9,10,10,0,0]}
{"id":"10476","tokens":["The","experiments","reported","in","this","study","were","designed","to","address","the","signaling","events","triggered","by","TCR","engagement","that","are","important","for","regulating","CD95","ligand","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,0,0,0]}
{"id":"16398","tokens":["The","other","is","a","region","interposed","between","the","21-bp","elements","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0]}
{"id":"6079","tokens":["In","conclusion",",","these","data","show","that","IL-10","induces","c-fos","expression","in","human","B-cells","by","activation","of","tyrosine","and","serine\/threonine","kinases","."],"ner_tags":[0,0,0,0,0,0,0,9,0,1,0,0,7,8,0,0,0,0,0,9,10,0]}
{"id":"13071","tokens":["As","determined","by","tyrosine","phosphorylation",",","nuclear","translocation","and","binding","to","an","hSIE-oligonucleotide","probe",",","IL-2","and","IL-15","activated","the","slowly","migrating","isoform",",","Stat3alpha","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,9,0]}
{"id":"17411","tokens":["Cyclosporin","A","and","FK506","inhibited","only","transcriptional","activation","that","was","dependent","on","Ca2+","mobilization","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9494","tokens":["To","further","clarify","the","complex","transcriptional","regulation","of","the","human","GM-CSF","gene",",","which","was","extensively","investigated","in","activated","T","cells",",","we","have","studied","the","role","of","an","upstream","NF-kappaB","like","site","in","the","5637","non-lymphoid","cell","line",",","which","derives","from","a","bladder","carcinoma","and","constitutively","produces","GM-CSF","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,1,2,2,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"9031","tokens":["All","erythroid","colonies","consisted","of","ringed","sideroblasts","exclusively","showed","one","pattern","dominant","in","those","of","PMNCs","."],"ner_tags":[0,5,6,0,0,7,8,0,0,0,0,0,0,0,0,7,0]}
{"id":"13540","tokens":["Effects","of","overexpression","of","IL-1","receptor-associated","kinase","on","NFkappaB","activation",",","IL-2","production","and","stress-activated","protein","kinases","in","the","murine","T","cell","line","EL4","."],"ner_tags":[0,0,0,0,9,10,10,0,9,0,0,9,0,0,0,0,0,0,0,5,6,6,6,6,0]}
{"id":"6412","tokens":["Block","of","granulocytic","differentiation","of","32Dcl3","cells","by","AML1\/ETO","(","MTG8",")","but","not","by","highly","expressed","Bcl-2","."],"ner_tags":[0,0,0,0,0,5,6,0,1,2,2,2,0,0,0,0,0,9,0]}
{"id":"8394","tokens":["We","demonstrate","that","binding","of","HMG-I","(","Y",")","to","this","oligonucleotide","causes","bending\/flexure","of","the","DNA","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"16872","tokens":["Because","1",",","25","(","OH",")","2D3","can","improve","the","capacity","of","macrophages","to","kill","mycobacteria",",","our","results","support","the","conclusion","that","macrophage-lymphocyte","interactions",",","mediated","at","least","in","part","by","1",",","25","(","OH",")","2D3",",","may","be","an","important","component","of","a","successful","antituberculous","immune","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3684","tokens":["A","direct","temporal","correlation","exists","between","HIV","infection","and","the","appearance","of","NF-kappaB","DNA-binding","activity","in","myelomonoblastic","PLB-985","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,5,6,6,0]}
{"id":"15472","tokens":["CLEO","defines","a","binding","site","for","protein","(","s",")","whose","optimum","binding","is","stimulated","by","PMA","and","A23187","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12242","tokens":["Herein","we","demonstrate","that","the","inducible","nuclear","import","of","NF-kappa","B",",","AP-1",",","NFAT",",","and","STAT1","in","Jurkat","T","lymphocytes","is","significantly","inhibited","by","a","cell-permeable","peptide","carrying","the","NLS","of","the","NF-kappa","B","p50","subunit","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,0,0,9,0,5,6,6,0,0,0,0,0,0,0,0,0,9,0,0,9,10,10,10,0]}
{"id":"10631","tokens":["Furthermore",",","increasing","the","spacing","between","the","CRE","and","the","kappaB3","sites","completely","abolished","LPS","induction",",","suggesting","a","cooperative","interaction","between","c-Jun","complexes","and","p50\/p65","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0]}
{"id":"17293","tokens":["Involvement","of","a","second","lymphoid-specific","enhancer","element","in","the","regulation","of","immunoglobulin","heavy-chain","gene","expression","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,1,2,2,0,0]}
{"id":"15171","tokens":["MR","were","reduced","before","delivery","(","96","+\/-","27","receptors\/cell",")",",","and","SPD","increased","(","64","+\/-","8","mV",")",",","with","both","parameters","normalizing","after","delivery","(","MR",",","242","+\/-","79",";","SPD",",","14.0","+\/-","4","mV",")","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15289","tokens":["This","was","also","true","for","KBF","(","p50","homodimer",")","binding","activity","in","U937","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"1847","tokens":["J","delta","K","cells","may","provide","a","useful","model","for","characterizing","NF-kappa","B","-independent","transcriptional","activation","of","the","HIV","LTR","."],"ner_tags":[5,6,6,6,0,0,0,0,0,0,0,9,10,0,0,0,0,0,1,2,0]}
{"id":"8313","tokens":["Functional","DC","characteristics","include","fluid","phase","macromolecule","uptake","(","FITC-dextran",")","and","activation","of","resting","T","cells","."],"ner_tags":[0,7,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"4166","tokens":["This","finding","may","lead","to","a","better","understanding","of","the","reasons","for","the","prevalence","of","lupus","in","females","and","of","the","estrogenic","effects","on","SLE","disease","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12804","tokens":["However",",","not","only","is","expression","of","the","beta-casein","gene","regulated","by","STAT5","but","it","is","also","affected","by","other","molecules","such","as","glucocorticoid","and","Ras","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"5066","tokens":["Oligonucleotides","containing","the","IL-13","or","IL-4","P","element","sites","specifically","bound","the","transcriptional","activator","protein",",","nuclear","factor-activated","T","cells",",","preformed","(","NF-ATp",")",",","when","incubated","with","nuclear","protein","extracts","from","activated","T","cells","."],"ner_tags":[0,0,0,9,0,1,2,2,2,0,0,0,9,10,10,0,9,10,10,10,0,0,0,9,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"1105","tokens":["Selected","transfected","clones","produced","low","levels","of","IFN","A","(","IFNA",")","constitutively",",","and","their","abilities","to","express","interleukin-2","and","interleukin-2","receptor","upon","stimulation","with","phytohemagglutinin","and","phorbol","myristate","acetate","were","retained","."],"ner_tags":[0,5,6,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,9,0,9,10,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"17359","tokens":["In","the","examination","of","the","induction","of","autoimmunity","in","transgenic","mice",",","evidence","has","been","obtained","further","implicating","the","lymphokine","interferon-gamma","in","the","etiology","of","autoimmunity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,9,0,0,0,0,0,0]}
{"id":"744","tokens":["Although","glucocorticosteroids","are","a","very","effective","treatment","for","asthma","and","other","chronic","inflammatory","diseases",",","a","small","proportion","of","patients","are","resistant","to","their","therapeutic","effects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5516","tokens":["In","conclusion",",","we","provide","evidence","that","PP2A","plays","a","crucial","role","in","the","regulation","of","STAT3","phosphorylation","and","subcellular","distribution","in","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,8,0]}
{"id":"7557","tokens":["In","parallel",",","NAC","was","shown","to","down-regulate","the","production","of","cytokines","by","DC","as","well","as","their","surface","expression","of","HLA-DR",",","CD86","(","B7-2",")",",","and","CD40","molecules","both","at","the","basal","state","and","upon","LPS","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,7,0,0,0,0,0,0,0,9,0,9,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"5846","tokens":["Compared","with","IL-2",",","CD3","ligation","induces","a","delayed","Stat3","binding","to","oligonucleotide","probes","from","the","ICAM-1","and","IL-2R","alpha","promoter","."],"ner_tags":[0,0,9,0,9,0,0,0,0,9,0,0,0,0,0,0,9,0,1,2,2,0]}
{"id":"16534","tokens":["We","report","the","identification","of","a","T","cell-specific","transcription","factor",",","TCF-1",",","binding","to","this","element","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,0,9,0,0,0,0,0,0]}
{"id":"1680","tokens":["Platelet-activating","factor","(","PAF",")","positively","auto-regulates","the","expression","of","human","PAF","receptor","transcript","1","(","leukocyte-type",")","through","NF-kappa","B","."],"ner_tags":[9,10,0,9,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,9,10,0]}
{"id":"6269","tokens":["To","propel","itself","in","infected","cells",",","the","pathogen","Shigella","flexneri","subverts","the","Cdc42","-controlled","machinery","responsible","for","actin","assembly","during","filopodia","formation","."],"ner_tags":[0,0,0,0,7,8,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0]}
{"id":"8788","tokens":["In","patients","whose","infiltration","of","c-fos-positive","lymphocytes","into","tumor","tissues","were","moderate","or","remarkable","at","4","Gy","of","radiotherapy",",","the","tumors","responded","significantly","well","to","radiation","therapy","(","P","<","0.025",",","chi2","test",")",",","and","the","patients","took","a","significantly","favorable","clinical","course","(","P","<","0.05",",","chi2","test",")","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6633","tokens":["Unlike","TNFR1",",","LMP1","can","interact","directly","with","receptor-interacting","protein","(","RIP",")","and","stably","associates","with","RIP","in","EBV-transformed","lymphoblastoid","cell","lines","."],"ner_tags":[0,9,0,9,0,0,0,0,9,10,0,9,0,0,0,0,0,9,0,5,6,6,6,0]}
{"id":"16086","tokens":["Circadian","rhythm","in","glucocorticoid","receptor","(","GR",")","was","studied","in","the","rat","liver","and","human","peripheral","leukocytes","."],"ner_tags":[0,0,0,9,10,0,9,0,0,0,0,0,7,8,0,7,8,8,0]}
{"id":"13548","tokens":["The","role","of","protein","kinase","C","signaling","in","activated","DRA","transcription","."],"ner_tags":[0,0,0,9,10,10,0,0,0,1,0,0]}
{"id":"9904","tokens":["Alcoholic","extracts","prepared","form","Arnicae","flos",",","the","collective","name","for","flowerheads","from","Arnica","montana","and","A.","chamissonis","ssp.","foliosa",",","are","used","therapeutically","as","anti-inflammatory","remedies","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16273","tokens":["Expression","of","c-jun",",","jun","B","and","jun","D","proto-oncogenes","in","human","peripheral-blood","granulocytes","."],"ner_tags":[0,0,1,2,2,2,2,2,2,2,0,7,8,8,0]}
{"id":"11286","tokens":["An","additional","complex","composed","of","p50\/RelA","(","p65",")","heterodimers","appeared","only","in","nuclear","extracts","from","7-day","MDMs","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,7,0]}
{"id":"16581","tokens":["LDP","not","only","increases","plasma","estradiol","levels",",","but","also","increases","the","leucocytic","ER","levels","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"6774","tokens":["We","report","that","two","20-epi","analogues",",","MC1627","and","MC1288",",","induced","differentiation","and","transcription","of","p21","(","Waf1",",","Cip1",")",",","a","key","VDR","target","gene","involved","in","growth","inhibition",",","at","a","concentration","100-fold","lower","than","that","of","1",",","25","(","OH",")","2D3","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16045","tokens":["This","suggests","that","diverse","agents","thought","to","activate","NF-kappa","B","by","distinct","intracellular","pathways","might","all","act","through","a","common","mechanism","involving","the","synthesis","of","ROI","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17730","tokens":["Expression","of","c-fos","correlates","with","IFN-alpha","responsiveness","in","Philadelphia","chromosome","positive","chronic","myelogenous","leukemia","."],"ner_tags":[0,0,1,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"18399","tokens":["In","conclusion",",","E1A","expression","marks","cells","for","destruction","by","the","host","NK","cell","response",",","whereas","the","E7","oncoprotein","lacks","this","activity","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,7,8,0,0,0,0,9,10,0,0,0,0]}
{"id":"17336","tokens":["These","data","suggest","that","the","abnormalities","of","the","HPA","system","in","AD","are","not","related","to","a","GR","deficiency","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"7307","tokens":["Expression","of","a","rapamycin-resistant","mutant","of","p70","(","s6k",")","in","T","cells","could","restore","rapamycin-suppressed","E2F","responses","."],"ner_tags":[0,0,0,9,10,0,9,10,10,10,0,7,8,0,0,0,9,0,0]}
{"id":"15440","tokens":["We","have","examined","the","effect","of","leukotriene","B4","(","LTB4",")",",","a","potent","lipid","proinflammatory","mediator",",","on","the","expression","of","the","proto-oncogenes","c-jun","and","c-fos","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"11254","tokens":["METHODS",":","Purified","T","cells","were","obtained","from","adenoidal","tissues",",","and","incubated","with","RA","(","10","(","-7",")","M",")","or","DMSO","solvent\/media","control","for","0",",","6-8",",","and","24","h","."],"ner_tags":[0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3279","tokens":["In","the","T3+","group",",","serum","total","thyroxine","(","TT4",")",",","free","T4","(","FT4",")",",","and","TSH","were","approx","50","%","lower","than","both","basal","and","T3-values","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8498","tokens":["Differential","induction","of","DNA-binding","activities","following","CD19","cross-linking","in","human","B","lineage","cells","."],"ner_tags":[0,0,0,9,10,0,9,0,0,7,8,8,8,0]}
{"id":"17231","tokens":["Alone",",","PMA","and","calcium","ionophore","A23187","did","not","affect",",","but","together","stimulated",",","like","phytohaemagglutinin","(","PHA",")",",","leucine","and",",","in","particular",",","thymidine","incorporation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8419","tokens":["Seven","preterms","developed","neonatal","respiratory","distress","syndrome","(","NRDS",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13849","tokens":["In","functional","studies",",","interferon-gamma-stimulated","PIEC","clones","transfected","with","this","mutated","CIITA","construct","failed","to","stimulate","purified","human","CD4+","T","lymphocytes","."],"ner_tags":[0,0,0,0,5,6,6,0,0,0,9,10,0,0,0,0,0,7,8,8,8,0]}
{"id":"12695","tokens":["These","domains",",","which","have","been","characterized","as","DNase","I","hypersensitive","sites","(","HSs",")",",","comprise","the","active","elements","of","the","LCR","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,0,1,0,0,0,0,0,0,0,0,1,0]}
{"id":"4644","tokens":["(","2E",")","-3-","[","5-","(","2",",","3-Dimethoxy-6-methyl-1",",","4-benzoquinoyl",")","]","-2-nonyl-2-","propenoic","acid","(","E3330",")",",","is","a","novel","agent","with","hepatoprotective","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1173","tokens":["Interestingly",",","while","increases","in","both","IL-1","beta","and","I","kappa","B","alpha\/MAD-3","mRNA","levels","were","detected","in","nuclei","of","adherent","monocytes",",","cytoplasmic","levels","of","IL-1","beta","mRNA","increased","during","adherence","whereas","those","of","I","kappa","B","alpha\/MAD-3","mRNA","did","not","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,3,4,4,0,0,0,0,0,0,3,4,4,4,4,0,0,0]}
{"id":"8625","tokens":["Four","patients","(","22","%",")","had","a","family","history","of","breast\/ovarian","cancer","in","at","least","one","first-","or","second-degree","relative",";","however",",","no","BRCA2","mutation","was","identified","among","them","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0]}
{"id":"11186","tokens":["PMLRAR","alpha","transgenic","mice","exhibited","impaired","neutrophil","maturation","early","in","life",",","which","progressed","at","a","low","frequency","over","the","course","of","several","months","to","overt","APL","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14477","tokens":["Thus",",","LPS","activation","of","human","monocytic","cells","results","in","nuclear","expression","of","c-Rel\/p50","and","p50\/p65","(","NF-kappa","B",")","and","induces","phosphorylation","of","MAD3","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,9,0,9,0,9,10,0,0,0,0,0,9,0]}
{"id":"3770","tokens":["In","contrast",",","neither","E","(","gre",")","nor","EA\/S","motifs","contributed","pronouncedly","to","Akv","MLV","transcription","in","NIH","3T3","cells","lacking","DNA-binding","ALF1","or","HEB","and","E2A","proteins","."],"ner_tags":[0,0,0,0,1,2,2,2,0,1,2,0,0,0,0,0,0,0,5,6,6,0,0,9,0,9,0,9,10,0]}
{"id":"9342","tokens":["All","fusions","splice","the","5","'","ends","of","the","3q21","genes","into","exon","2","of","the","EVI1","gene",",","an","event","that","is","similar","to","the","normal","intergenic","splicing","of","MDS1-EVI1","and","to","those","previously","documented","in","leukemias","with","t","(","3",";","21",")","and","t","(","3",";","12",")",",","in","which","acute","myelogenous","leukemia","1-EVI1","fusions","and","ETV6-EVI1","fusions",",","respectively",",","occur","."],"ner_tags":[0,0,0,0,1,2,2,0,0,1,2,0,1,2,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,2,2,2,2,2,0,1,2,2,2,2,2,0,0,0,0,1,2,2,2,0,1,2,0,0,0,0,0]}
{"id":"10408","tokens":["Additional","major","protein-DNA","interactions","do","not","occur","within","the","promoter","region","after","T","lymphocyte","activation",",","indicating","a","requirement","for","additional","protein-protein","interactions","and\/or","post-translational","modifications","of","pre-bound","transcription","factors","to","account","for","the","observed","increase","in","IMPDH","type","II","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2341","tokens":["Several","cis-acting","regulatory","sites","are","required","for","induction","of","the","IL-2","gene","after","stimulation","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,1,2,0,0,0]}
{"id":"2190","tokens":["Peripheral","blood","mononuclear","cells","from","seventeen","patients","with","primary","myelodysplastic","syndromes","(","MDS",")","in","advanced","stage","were","enriched","for","blasts","and","tested","for","(","1",")","karyotype",",","(","2",")","genomic","configuration","and","(","3",")","expression","of","IL-3",",","GM-CSF",",","FMS","and","EGR-1","genes","which","are","all","located","on","the","long","arm","of","chromosome","5","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0,0,1,2,2,2,2,0]}
{"id":"7185","tokens":["However",",","CTLA-4","ligation","did","not","appear","to","affect","the","CD28","-mediated","stabilization","of","IL-2","mRNA","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,9,0,0,0,3,4,0]}
{"id":"3700","tokens":["These","data","provide","important","fundamental","insights","into","the","molecular","mechanisms","by","which","the","c-Jun","delta-domain","functions","as","a","modulatory","switch","and","further","imply","that","the","functional","role","of","c-Jun","is","dictated","by","cell-specific","influences","and","the","delta-domain","motif","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0]}
{"id":"10435","tokens":["Both","Drosophila","Toll","and","the","IL-1","receptor","are","known","to","signal","through","the","NF-kappaB","pathway","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"15566","tokens":["In","vitro","inhibition","of","NF-kappa","B","expression","by","antisense","oligodeoxynucleotides","(","ODNs",")","inhibited","growth","of","these","culture-adapted","Tax-transformed","fibroblasts","as","well","as","an","HTLV-I-transformed","human","lymphocyte","line","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,5,6,6,6,0]}
{"id":"16852","tokens":["LPS","is","not","able","to","induce","HIV-1","production","in","a","cloned","T","cell","line","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"6620","tokens":["Programmed","cell","death","is","a","process","required","for","the","normal","development","of","an","organism","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11391","tokens":["We","report","here","that","the","signaling","cascade","triggered","by","interleukin-4","(","IL-4",")","or","anti-CD40","monoclonal","antibody","(","mAb",")","participates","in","NF-kappa","B","activation","responsible","for","germline","C","epsilon","transcription","in","a","human","Burkitt","lymphoma","B","cell","line",",","DND39","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,10,10,0,9,0,0,0,9,10,0,0,0,1,0,0,0,0,0,5,6,6,6,6,6,0,5,0]}
{"id":"407","tokens":["These","results","suggest","that","(","1",")","the","differentiation","inhibitory","activity","of","I-factor\/nm23","protein","is","not","restricted","to","monocytic","differentiation","of","M1","cells",",","(","2",")","the","inhibitory","activity","is","exhibited","without","species","specificity",",","and","(","3",")","the","differentiation","inhibitory","activity","of","the","nm23\/NDP","kinase","protein","is","independent","of","its","enzyme","activity","and","requires","the","presence","of","N-terminal","peptides","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10830","tokens":["Moreover",",","induction","of","G","(","S",")","alpha","expression","increased","events","distal","to","the","accumulation","of","cAMP","including","the","phosphorylation","of","the","transcription","factor",",","cAMP","response","element","binding","protein","and","transcriptional","activation","of","cAMP-dependent","reporter","genes","."],"ner_tags":[0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,1,2,2,0]}
{"id":"592","tokens":["TCF-1","knock-out","mice",",","generated","recently","in","our","laboratory",",","have","strongly","decreased","numbers","of","thymocytes",",","but","are","otherwise","normal","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0]}
{"id":"3955","tokens":["Subsequent","analysis","of","the","human","ICAM-1","promoter","has","revealed","that","both","12-O-tetradecanoylphorbol","13-acetate","(","TPA",")","and","tumour","necrosis","factor-alpha","(","TNF-alpha",")","upregulate","ICAM-1","expression","through","the","presence","of","a","nuclear","factor","(","NF-kappa","B",")","target","sequence","(","TGGAAATTCC",")","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,9,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0]}
{"id":"11429","tokens":["To","delineate","the","regulatory","mechanisms","of","human","IL-5","synthesis",",","we","established","allergen-specific","CD4+","T-cell","clones","from","asthmatic","patients","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,5,6,6,6,0,0,0,0]}
{"id":"6510","tokens":["These","data","suggest","that","NF-kappaB","plays","a","key","role","in","low","shear-induced","VCAM-1","expression","and","that","pathways","mediating","low","shear-","and","cytokine-induced","EC-Mn","adhesion","may","be","differentially","regulated","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17304","tokens":["Transactivation","by","some","DNA","viruses","has","been","implicated","in","inducing","HIV-1","replication","and","pathogenesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4395","tokens":["The","PML","gene","is","fused","to","the","retinoic","acid","receptor","alpha","(","RAR","alpha",")","gene","in","t","(","15",";","17",")","acute","promyelocytic","leukemia","(","APL",")",",","creating","a","PML-RAR","alpha","fusion","oncoprotein","."],"ner_tags":[0,1,2,0,0,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"8182","tokens":["Retinoid","X","receptor","(","RXR",")","agonist-induced","activation","of","dominant-negative","RXR","-retinoic","acid","receptor","alpha403","heterodimers","is","developmentally","regulated","during","myeloid","differentiation","."],"ner_tags":[9,10,10,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7444","tokens":["In","summary",",","our","results","provide","compelling","evidence","that","NF-kappaB","protects","against","Fas","-mediated","death","and","is","likely","to","be","an","important","regulator","of","T","cell","homeostasis","and","tolerance","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10151","tokens":["METHODS","AND","RESULTS",":","Incubation","of","human","whole","blood","with","platelet-activating","factor","(","PAF",",","1","mumol\/L",")","evoked","downregulation","of","L-selectin","and","upregulation","of","CD11\/CD18","adhesion","receptors","on","neutrophils","as","measured","by","flow","cytometry","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,9,0,0,0,9,9,10,0,0,0,0,0,0,0,0]}
{"id":"7471","tokens":["We","investigated","whether","E2","and","Prog","could","interfere","with","TNF-alpha","-induced","apoptosis","of","the","monoblastoid","U937","cell","line","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,5,6,6,6,0]}
{"id":"16265","tokens":["Levels","of","RNA","coding","for","the","receptor","were","not","modulated","by","exposure","to","high","levels","of","ligand","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1479","tokens":["Erythropoietin","(","Epo",")",",","granulocyte\/macrophage","colony","stimulating","factor","(","GM-CSF",")",",","and","interleukin","3","(","IL-3",")","promoted","the","growth","of","NS-Meg","cells","."],"ner_tags":[9,0,9,0,0,9,10,10,10,0,9,0,0,0,9,10,0,9,0,0,0,0,0,5,6,0]}
{"id":"4575","tokens":["Both","IL-4","and","IL-10","were","seen","to","inhibit","IL-6","production","and","the","expression","of","IL-6","mRNA","in","both","monocytic","cell","lines","studied","."],"ner_tags":[0,9,0,9,0,0,0,0,9,0,0,0,0,0,3,4,0,0,5,6,6,0,0]}
{"id":"920","tokens":["The","efficacy","of","serotonin","reuptake","inhibitors","(","SRIs",")","is","uncertain",",","and","response","predictors","are","unavailable","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6814","tokens":["In","patients","with","connective","tissue","diseases",",","systemic","hGR","levels","were","also","found","to","be","decreased","in","the","absence","of","glucocorticoid","treatment","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9852","tokens":["This","cooperation","was","also","required","to","induce","the","sustained","proliferation","of","differentiation-blocked","erythroblasts","in","response","to","ligand","activation","of","the","endogenous","tyrosine","kinase","receptor","c-Kit","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,9,10,10,10,9,0]}
{"id":"3590","tokens":["Electrophoretic","mobility","shift","assays","(","EMSA",")","with","a","43-mer","oligonucleotide","derived","from","the","functionally","identified","cis-acting","element","revealed","specific","complexes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"2523","tokens":["This","was","supported","by","the","observation","that","the","down-regulatory","capacity","of","IL-4","appeared","to","be","dependent","on","de","novo","protein","synthesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"14284","tokens":["So","far",",","there","are","no","drugs","or","therapy","available","that","can","provide","protection","against","HIV-1","latency","reactivation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15816","tokens":["Elf-1","contains","a","DNA","binding","domain","that","is","nearly","identical","to","that","of","E74",",","the","ecdysone-inducible","Drosophila","transcription","factor","required","for","metamorphosis","(","hence","the","name","Elf-1",",","for","E74-like","factor","1",")","."],"ner_tags":[9,0,0,9,10,10,0,0,0,0,0,0,0,9,0,0,9,10,10,10,0,0,0,0,0,0,0,9,0,0,9,10,10,0,0]}
{"id":"8151","tokens":["Our","data","suggests","that","CoCl2-induced","cellular","signals","directing","increased","expression","of","VCAM-1","in","HUVEC","involve","downstream","activation","of","MAP","kinase","and","NF-kappaB",",","while","the","phosphorylation","of","PECAM-1","occurs","as","a","result","of","activation","of","PKC","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,7,0,0,0,0,9,10,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"1116","tokens":["This","study","investigated","age-related","T","cell","responses","after","in","vitro","exposure","to","influenza","A","virus","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4944","tokens":["The","EGR1","binding","motif","was","shown","to","be","necessary","for","stimulus-induced","expression","of","a","CD44","promoter-chloramphenicol","acetyltransferase","reporter","construct","in","nontransformed","B","lymphocytes","and","was","required","for","transactivation","by","an","EGR1","expression","vector","in","a","B-cell","line","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,0,0,9,1,2,2,2,0,7,8,8,0,0,0,0,0,0,0,1,2,2,0,0,5,6,0]}
{"id":"10968","tokens":["Inhibition","of","GATA-3","activity","has","therapeutic","potential","in","the","treatment","of","asthma","and","other","hypereosinophilic","diseases","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12119","tokens":["The","mean","dissociation","constant","(","KD",")","was","similar","in","both","groups","of","patients","and","in","healthy","women","(","A-CRF",":","0.7","+\/-","0.5","x","10","(","-10",")","M",";","M-CRF",":","1.1","+\/-","0.9","x","10","(","-10",")","M",";","controls",":","1.0","+\/-","0.6","x","10","(","-10",")","M",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6348","tokens":["These","interactions","require","ATP\/Mg2+","and","when","ATP","is","limiting","the","PR","complex","is","altered","to","one","containing","the","proteins","p60","and","p48",",","but","lacking","immunophilins","and","p23","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,9,0,0,0,9,0,9,0]}
{"id":"266","tokens":["Furthermore",",","these","data","may","provide","new","insights","into","the","slow","rate","of","HCMV","DNA","replication","in","cells","and","the","possible","involvement","of","HCMV","in","tumorigenesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12801","tokens":["Copyright","1998","Academic","Press","."],"ner_tags":[0,0,0,0,0]}
{"id":"1030","tokens":["To","gain","further","insight","into","the","molecular","mechanisms","that","control","tal-1","expression",",","we","investigated","tal-1","chromatin","structure","in","erythroid\/megakaryocytic","cell","lines","and","in","T-cell","lines","either","with","or","without","tal-1","rearrangements","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,5,6,6,0,0,5,6,0,0,0,0,1,2,0]}
{"id":"13705","tokens":["Abnormalities","of","I","or","more","signaling","molecules","were","found","in","9","of","14","patients",";","however",",","only","3","patients","had","T","cells","that","exhibited","all","5","defects","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"4937","tokens":["Role","of","EGR1","in","regulation","of","stimulus-dependent","CD44","transcription","in","B","lymphocytes","."],"ner_tags":[0,0,9,0,0,0,0,9,0,0,0,0,0]}
{"id":"2573","tokens":["Co-infection","of","T","cells","by","HIV-1","and","HHV-6","can","lead","to","both","activation","of","the","HIV-1","promoter","and","acceleration","of","the","cytopathic","effects","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0]}
{"id":"14264","tokens":["Chlorinated","dibenzo-p-dioxins","and","dibenzofurans","and","the","human","immune","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"17311","tokens":["Quantitative","immunohistochemical","analysis","of","mononuclear","infiltrates","in","breast","carcinomas","--","correlation","with","tumour","differentiation","."],"ner_tags":[0,0,0,0,7,8,0,0,0,0,0,0,0,0,0]}
{"id":"15047","tokens":["Additionally",",","Nef","inhibits","the","induction","of","HIV-1-","and","interleukin","2-directed","gene","expression",",","and","the","effect","on","HIV-1","transcription","depends","on","an","intact","NF-kappa","B-binding","site","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"11814","tokens":["We","found","that","NFATx1","DNA","binding","activity","and","interaction","with","AP-1","polypeptides","were","dependent","on","its","central","Rel","similarity","region","and","that","transcriptional","activation","was","reduced","by","deletions","of","either","its","N-terminal","domain","or","its","C-terminal","domain",",","suggesting","the","presence","of","intrinsic","transcriptional","activation","motifs","in","both","regions","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,0,0,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"11754","tokens":["Neither","a","mutation","in","I","kappaB","alpha","nor","a","mutation","in","p50","or","relA",",","the","two","major","subunits","of","NF-kappaB","in","this","cell","line",",","accounts","for","this","phosphorylation","defect","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,9,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14311","tokens":["These","results","may","also","provide","a","clue","to","understanding","of","the","molecular","process","of","AIDS","pathogenesis","and","its","possible","biochemical","intervention","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16093","tokens":["Thus",",","we","postulated","that","the","circadian","modification","of","GR","was","independent","of","the","diurnal","fluctuations","in","plasma","cortisol","level","or","the","circadian","variations","in","environmental","lighting","and","that","the","rhythmicity","might","be","regulated","by","the","'circadian","pacemaker","'","located","in","the","human","basal","brain","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15653","tokens":["Perhaps","murine","thymocytes","are","denied","this","form","of","rescue","because","they","shut","off","IL-2R","beta","chain","expression","at","an","earlier","stage","or","because","they","may","be","uncommonly","Bcl-2","deficient","(","cf.","Sentman","et","al.",",","1991",";","Strasser","et","al.",",","1991",")","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15616","tokens":["Cortisol","receptor","resistance",":","the","variability","of","its","clinical","presentation","and","response","to","treatment","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10057","tokens":["Hypoxic","endothelia","showed","a",">","10-fold","increase","in","sensitivity","to","inhibitors","of","proteasome","activation",",","and","combinations","of","hypoxia","and","LPS","enhanced","proteasome","-dependent","cytoplasmic-to-nuclear","localization","of","the","nuclear","transcription","factor-kappa","B","p65","(","Rel","A",")","subunit","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,10,10,10,10,10,10,10,10,0]}
{"id":"694","tokens":["We","also","found","that","mRNAs","encoding","GATA-1","and","GATA-2","are","expressed","in","all","these","cases","."],"ner_tags":[0,0,0,0,3,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"14190","tokens":["The","study","of","human","disorders","known","as","premature","aging","syndromes","may","provide","insight","into","the","mechanisms","of","cellular","senescence","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13155","tokens":["The","ability","of","mutants","to","activate","a","reporter","gene","under","the","control","of","MHC","class","II","conserved","W-X-Y","or","X-Y","regulatory","elements","was","determined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,1,2,2,2,2,0,0,0]}
{"id":"13501","tokens":["NFATx1","is","expressed","predominantly","in","the","thymus","and","peripheral","blood","leukocyte",",","while","the","skeletal","muscle","expressed","primarily","NFATx2","."],"ner_tags":[9,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,9,0]}
{"id":"2028","tokens":["We","have","examined","the","role","of","cell","surface","molecules","in","these","responses","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16234","tokens":["Nuclear","run-on","experiments","demonstrated","decreased","transcription","of","kappa","L","chain","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0]}
{"id":"7028","tokens":["Function","tests","in","MS","have","revealed","dysregulation","of","the","hypothalamic-pituitary-adrenal","system","in","a","substantial","proportion","of","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8247","tokens":["We","conclude","from","these","studies","that","the","phosphorylation","of","TRAF2","is","likely","to","play","an","important","role","in","regulating","signaling","by","virtue","of","its","ability","to","influence","the","CD40","-TRAF2","interaction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,9,0,0]}
{"id":"9182","tokens":["However",",","plasma","free","cortisol","concentrations","were","similar","in","the","three","groups","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"442","tokens":["At","10","microM",",","both","compounds","inhibited","IL-2","mRNA","and","protein","levels","in","the","NFAT-1-linked","lac-Z","transfectants",",","and","in","human","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,7,8,0]}
{"id":"8690","tokens":["Using","this","approach","we","first","show","that","reactivities","to","the","immunodominant","and","subdominant","lytic","cycle","epitopes","identified","by","T","cells","during","primary","EBV","infection","are","regularly","detectable","in","the","CTL","memory","of","virus","carriers",";","this","implies","that","in","such","carriers","chronic","virus","replication","remains","under","direct","T-cell","control","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7280","tokens":["However",",","stimulation","with","IL-2","resulted","in","Jak3","and","STAT5","phosphorylation","in","both","leukemic","ATLL","cells","and","IL-2-dependent","lines","."],"ner_tags":[0,0,0,0,9,0,0,9,0,9,0,0,0,7,8,8,0,5,6,0]}
{"id":"8193","tokens":["IL-12","and","IL-2","can","stimulate","mitogen-","or","CD3-activated","T","cells","to","proliferate",",","produce","IFN-gamma",",","and","kill","tumor","cells","."],"ner_tags":[9,0,9,0,0,7,8,8,8,8,0,0,0,0,9,0,0,0,7,8,0]}
{"id":"7493","tokens":["In","contrast",",","HePTP","had","no","effects","on","N-terminal","c-Jun","kinase","or","on","events","upstream","of","the","MAP","kinases","."],"ner_tags":[0,0,0,9,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"14874","tokens":["This","indicates","an","increase","in","either","episomal","DNA","or","concatameric","linear","DNA","."],"ner_tags":[0,0,0,0,0,0,1,2,0,1,2,2,0]}
{"id":"14120","tokens":["RESULTS","."],"ner_tags":[0,0]}
{"id":"6527","tokens":["Pertussis","toxin",",","which","ADP-ribosylates","the","Gi","proteins","known","to","couple","to","the","C5a","receptor",",","produced","minimal","inhibition","of","C5a-induced","IL-8","expression","and","had","little","effect","on","C5a-induced","calcium","mobilization","in","RAW264.7","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"1645","tokens":["Elf-1","physically","associated","with","HMG-I","and","with","NF-kappa","B","p50","and","c-Rel","in","vitro",",","suggesting","that","protein-protein","interactions","might","functionally","coordinate","the","actions","of","the","upstream","and","downstream","positive","regulatory","elements","."],"ner_tags":[9,0,0,0,9,0,0,9,10,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,0]}
{"id":"8420","tokens":["The","number","of","GR","and","the","Kd","were","similar","in","the","term","and","preterm","(","with","and","without","NRDS",")","babies","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9726","tokens":["Five","healthy","human","leukocyte","antigen-B8","(","HLA-B8",")","-positive","virus","carriers","were","studied","to","investigate","the","CD8+","cytotoxic","T","lymphocyte","(","CTL",")","response","to","an","HLA-B8-restricted","peptide",",","RAKFKQLLQ",",","located","in","the","Epstein-Barr","virus","(","EBV",")","immediate-early","trans-activator","protein",",","BZLF1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,9,0]}
{"id":"13649","tokens":["IL-7","did","not","maintain","v-Abl","-mediated","differentiation","arrest","of","the","pre-B","cells",",","as","activation","of","NF-kappaB","and","RAG","gene","transcription","was","unaffected","by","IL-7","."],"ner_tags":[9,0,0,0,9,0,0,0,0,0,7,8,0,0,0,0,9,0,1,2,0,0,0,0,9,0]}
{"id":"233","tokens":["We","propose","that","NO","'s","ability","to","limit","endothelial","activation","and","inhibit","monocyte","adhesion","may","contribute","to","some","of","its","antiatherogenic","and","antiinflammatory","properties","within","the","vessel","wall","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8589","tokens":["Mildly","oxLDLs","(","50","and","100","microgram\/ml",")","decreased","the","number","of","lymphoblasts","and","the","level","of","IL-2","concentration","in","the","culture","supernatants","after","activation","of","lymphocytes","by","phytohaemagglutinin","and","PMA+ionomycin","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,9,0,0,0]}
{"id":"13942","tokens":["Simple","activation","of","RXRs","is","not","sufficient","to","induce","apoptosis","of","the","cells","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"15876","tokens":["The","promoter","of","the","major","histocompatibility","class","II","gene","DRA","contains","an","octamer","element","(","ATTTGCAT",")","that","is","required","for","efficient","DRA","expression","in","B","cells","."],"ner_tags":[0,0,0,0,1,2,2,2,2,1,0,0,1,2,0,0,0,0,0,0,0,0,1,0,0,7,8,0]}
{"id":"13800","tokens":["The","binding","of","interleukin-2","(","IL-2",")","to","its","receptor","on","normal","T","cells","induces","nuclear","expression","of","nuclear","factor","kappaB","(","NF-kappaB",")",",","activation","of","the","IL-2","receptor","(","IL-2R",")","alpha","chain","gene",",","and","cell","proliferation","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,0,7,8,0,0,0,0,9,10,10,0,9,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0]}
{"id":"937","tokens":["The","specificity","of","MNDA","expression","for","cells","in","the","granulocyte-macrophage","lineage","was","reexamined","in","cell","lines","established","from","patients","with","Philadelphia","chromosome-positive","chronic","myeloid","leukemia","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0]}
{"id":"1157","tokens":["We","further","found","that","high","activities","of","the","transcriptional","activators",",","GATA-1","and","SP1",",","are","associated","with","normal","adult","erythroid","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"16403","tokens":["In","contrast",",","the","C26","element","itself","was","profoundly","activated","upon","stimulation","with","12-O-tetradecanoylphorbol-13-acetate","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0]}
{"id":"7622","tokens":["When","activated",",","glucocorticoid","receptors","form","a","dimer","and","bind","to","DNA","after","migration","into","the","nucleus","."],"ner_tags":[0,0,0,9,10,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"11625","tokens":["The","HLA","DQA1","locus","is","polymorphic","."],"ner_tags":[0,1,2,2,0,0,0]}
{"id":"15129","tokens":["No","positive","effect","of","the","duplicated","CTG-motif","could","be","detected","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,0]}
{"id":"15145","tokens":["However",",","in","contrast","to","GATA-1",",","SCL","is","expressed","in","the","developing","brain","."],"ner_tags":[0,0,0,0,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"1577","tokens":["In","addition","we","assayed","the","level","of","mRNA","encoding","c-Fos",",","a","common","component","of","AP-1","and","observed","that","it","was","indeed","up-regulated","in","infected","cells","."],"ner_tags":[0,0,0,0,0,0,0,3,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"15717","tokens":["We",",","therefore",",","examined","glucocorticoid","receptor","characteristics","on","mononuclear","leukocytes","by","measuring","[","3H","]","dexamethasone","binding","and","the","effect","of","dexamethasone","on","[","3H","]","thymidine","incorporation",",","which","is","one","of","the","effects","of","glucocorticoid","receptor","activation","."],"ner_tags":[0,0,0,0,0,9,10,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"14615","tokens":["We","can","now","study","regulatory","regions","and","functional","domains","of","the","protein","in","the","context","of","a","true","erythroid","environment",",","experiments","that","have","not","been","possible","heretofore","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3474","tokens":["High-dose","pulse","glucocorticoid","therapy","has","been","used","successfully","in","the","clinic","in","severe","pathological","conditions","for","about","20","years","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18348","tokens":["Finally",",","we","demonstrate","that","C\/EBP","alpha","can","also","active","the","GM-CSF","receptor","alpha","promoter","in","nonmyeloid","cells","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,1,2,2,2,0,7,8,0]}
{"id":"3864","tokens":["This","Oct-1","-binding","phenotype","remained","stable","in","culture","for","up","to","3","days","prior","to","activation","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1061","tokens":["Molecular","mechanisms","leading","to","restricted","HIV-1","replication","may","differ","between","certain","cell","types","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17443","tokens":["We","have","examined","the","role","of","phosphorylation","on","Rex","function","by","using","a","protein","kinase","inhibitor",",","H-7","[","1-","(","5-isoquinolinyl-sulfonyl",")","-2-methylpiperazine","]","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12129","tokens":["We","compared","the","pattern","using","nuclear","extracts","from","human","brain","and","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"9329","tokens":["Dithiocarbamates","(","DTCs",")","have","recently","been","reported","as","powerful","inhibitors","of","NF-kappaB","activation","in","a","number","of","cell","types","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"12433","tokens":["In","contrast",",","a","significant","correlation","between","NGAL","expression","in","breast","cancer","was","found","with","several","other","markers","of","poor","prognosis",",","including","estrogen","and","progesterone","receptor","-negative","status","and","high","proliferation","(","S-phase","fraction",")","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"11676","tokens":["These","observations","implicated","c-Rel","as","an","IL-2","promoter","factor",",","for","which","experimental","support","was","obtained","from","transient","transfection","experiments","."],"ner_tags":[0,0,0,9,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4101","tokens":["To","address","possible","mechanisms","that","could","explain","this","selective","activity","of","c-ErbB",",","we","analyzed","the","ability","of","these","receptors","to","activate","the","different","members","of","the","Stat","transcription","factor","family","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"16697","tokens":["Positive","hybridization","was","found","in","thymus",",","tonsil",",","bone","marrow",",","developing","vessels",",","and","in","fetal","brain","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1382","tokens":["Further",",","like","PMA",",","TG","markedly","induced","NF","kappa","B","in","Jurkat","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,5,6,6,0]}
{"id":"2834","tokens":["J393\/CD43","was","found","to","be","hyposialylated",",","bearing","predominantly","O-linked","monosaccharide","glycans",",","whereas","G10-2\/CD43","bore","complex","sialylated","tetra-","and","hexasaccharide","chains","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"940","tokens":["By","contrast",",","three","lymphoblastoid","cell","lines","(","immortalized","in","vitro","with","Epstein-Barr","virus",")","were","weakly","positive","and","MNDA","was","up-regulated","by","interferon-alpha","(","IFN-alpha",")","treatment","."],"ner_tags":[0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,0,9,0,0,0]}
{"id":"13472","tokens":["Analyzed","DNA","sequences","included","delta","and","beta","5","'","flanking","regions","extending","from","approximately","-500","to","+50bp","(","promoter","regions",")",",","truncated","delta","and","beta","5","'","flanking","regions","extending","from","approximately","-250","to","+50","bp",",","and","chimeric","promoter","constructions",",","which","consisted","of","a","distal","delta","or","beta","fragment","fused","to","a","proximal","beta","or","delta","sequence","."],"ner_tags":[0,1,2,0,1,2,2,2,2,2,2,0,0,0,1,2,2,0,1,2,0,0,0,0,0,1,2,2,2,2,0,0,0,1,2,2,2,0,0,1,2,2,0,0,0,0,0,0,1,2,2,2,0,0,0,1,2,2,2,2,0]}
{"id":"9654","tokens":["In","vitro",",","CsA","inhibits","lymphocyte","gene","activation","by","inhibiting","the","phosphatase","activity","of","calcineurin","(","CN",")","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,9,0,0,9,0,9,0,0]}
{"id":"16909","tokens":["[","Glucocorticoid","receptors","in","peripheral","blood","lymphocytes","of","patients","with","bronchial","asthma","]"],"ner_tags":[0,9,10,0,7,8,8,0,0,0,0,0,0]}
{"id":"3036","tokens":["This","contrasts","with","induction","of","c-fos","by","both","CD40","and","sIg",",","which","is","PKC","independent","and","indicates","that","CD40","is","capable","of","signaling","through","PKC","or","a","closely","related","kinase","."],"ner_tags":[0,0,0,0,0,1,0,0,9,0,9,0,0,0,9,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,9,0]}
{"id":"4996","tokens":["Among","24","ALL",",","6","were","of","the","null","and","11","of","the","common","type","and","all","these","were","negative","for","A-myb","expression",";","on","the","other","hand",",","all","7","B-ALL","cases","(","slg+",")",",","as","well","as","one","fresh","BL","case","with","bone","marrow","infiltration",",","expressed","A-myb","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0]}
{"id":"11660","tokens":["Regulation","of","NFAT","could","be","therefore","a","critical","element","in","the","polarization","to","eTh1","or","eTh2","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,7,0,7,0]}
{"id":"8517","tokens":["The","regulatory","regions","of","several","genes","specifically","expressed","in","B","cells","contain","functional","binding","sites","for","Oct2","."],"ner_tags":[0,1,2,0,0,0,0,0,0,7,8,0,1,2,2,0,9,0]}
{"id":"7887","tokens":["In","the","present","study","we","investigated","the","possible","involvement","of","the","mitogen-activated","protein","kinase","family","members","extracellular-regulated","kinase","1\/2","(","ERK1\/2",")","and","c-","Jun","N-terminal","kinase","(","JNK",")","in","mediating","IL-6","gene","expression","in","human","monocytes",",","in","particular","their","role","in","enhancing","NF-kappa","B","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,10,10,0,9,0,0,0,9,10,10,0,9,0,0,0,9,0,0,0,7,8,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"966","tokens":["Coordinate","with","temporal","changes","in","Ig","synthesis",",","the","DNA-binding","activity","and","the","synthesis","of","the","B","cell-enriched","transcription","factor","Oct-2","are","regulated","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,10,10,10,9,0,0,0]}
{"id":"3323","tokens":["Collectively","this","study","shows","that","expression","of","the","Btk","gene","is","regulated","by","the","combined","action","of","Sp1-","and","PU.1-family","members","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"10028","tokens":["Purified","HLA-DM-DO","complexes","could","not","promote","peptide","exchange","in","vitro","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0]}
{"id":"7895","tokens":["The","Epstein-Barr","virus","nuclear","antigen","2","(","EBNA2",")",",","a","protein","required","for","B","lymphocyte","immortalization",",","induces","the","synthesis","of","type","I","interferon","in","Burkitt","'s","lymphoma","cell","lines","."],"ner_tags":[0,9,10,10,10,10,0,9,0,0,0,0,0,0,7,8,0,0,0,0,0,0,9,10,10,0,5,6,6,6,6,0]}
{"id":"6174","tokens":["Moreover",",","following","incubation","with","the","anti-rabbit","hsp90","monoclonal","antibody","the","sedimenting","gradient","showed","a","10.4S","sedimenting","complex","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,9,10,10,0]}
{"id":"14135","tokens":["Human","CD3-CD16+","natural","killer","cells","express","the","hGATA-3","T","cell","transcription","factor","and","an","unrearranged","2.3-kb","TcR","delta","transcript","."],"ner_tags":[5,6,6,6,6,0,0,9,10,10,10,10,0,0,0,9,10,10,10,0]}
{"id":"2289","tokens":["Such","observations","indicate","that","IL-4","Stat","has","the","same","functional","domain","for","both","receptor","coupling","and","dimerization","."],"ner_tags":[0,0,0,0,9,10,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"9985","tokens":["Consequently",",","LMP-1","triggers","the","activity","of","the","c-Jun","N-terminal","transactivation","domain","which","is","known","to","be","activated","upon","JNK","-mediated","phosphorylation","."],"ner_tags":[0,0,9,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"531","tokens":["Functional","roles","of","in","vivo","footprinted","DNA","motifs","within","an","alpha-globin","enhancer","."],"ner_tags":[0,0,0,1,2,2,2,2,0,0,1,2,0]}
{"id":"8057","tokens":["Cellular","disposition","of","sulphamethoxazole","and","its","metabolites",":","implications","for","hypersensitivity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10045","tokens":["Addition","of","neutralizing","anti-TNF-alpha","antibodies","drastically","reduced","p24","antigen","release","and","prevented","CD4+","cell","depletion","associated","with","infection","."],"ner_tags":[0,0,0,9,10,0,0,9,10,0,0,0,9,0,0,0,0,0,0]}
{"id":"3042","tokens":["Pharmacological","modification","of","cytokine","dysregulation",",","therefore",",","has","been","suggested","as","a","therapeutic","modality","for","HIV-1","infection","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15882","tokens":["Recombinant","OTF-2","protein","produced","by","in","vitro","transcription\/translation","could","also","enhance","DRA","gene","transcription","in","vitro","."],"ner_tags":[9,10,10,0,0,0,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"9066","tokens":["Addition","of","exogenous","IL-2","to","IL-10-treated","cells","significantly","reversed","the","antiproliferative","effects","of","IL-10","."],"ner_tags":[0,0,0,9,0,5,6,0,0,0,0,0,0,9,0]}
{"id":"16230","tokens":["Internal","labeling","with","[","35S","]","methionine","and","immunoprecipitation","with","anti-IgM",",","anti-kappa",",","and","anti-lambda","antibodies","revealed","a","striking","reduction","in","kappa","L","chain","in","the","presence","of","TGF-beta","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,10,0,0,0,0,0,9,10,10,0,0,0,0,9,0]}
{"id":"7133","tokens":["Advances","in","gene","technology","have","allowed","the","manipulation","of","molecular","interactions","that","shape","the","T","cell","repertoire","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7694","tokens":["Interestingly",",","enhanced","expression","of","Spi-1","and","Fli-1","genes","already","was","detected","in","the","Ter","119","positive","cell","population","of","transgenic","mice","spleen","in","vivo","."],"ner_tags":[0,0,0,0,0,1,2,2,2,0,0,0,0,0,5,6,6,6,6,0,0,0,0,0,0,0]}
{"id":"6123","tokens":["Electrophoretic","mobility","shift","assays","(","EMSAs",")","showed","that","recombinant","C\/EBPbeta","protein","could","bind","to","the","potential","C\/EBP-binding","site","(","bp","-90","to","-82",")","in","the","MBP","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,1,2,0,1,2,2,2,0,0,0,9,0,0]}
{"id":"9119","tokens":["Thus",",","an","adherent","population","of","cells",",","with","preosteoclast\/","osteoclast","phenotypic","properties",",","arises","selectively","under","simple","culture","conditions","from","normal","PBMC","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"3087","tokens":["However",",","the","nature","of","the","subunit","involved","in","this","mechanism","has","not","been","defined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13265","tokens":["In","addition",",","Tax","also","stimulates","the","transcription","of","the","E2F-1","gene","itself","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,1,2,0,0]}
{"id":"3821","tokens":["Transfection","of","trans-dominant","negative","expression","vectors","of","ras","and","raf",",","together","with","AP-1-dependent","reporter","constructs",",","as","well","as","Western","blot","analysis","using","anti-ERK","(","extracellular","signal-regulated","kinase",")","antibodies",",","indicated","that","the","Ras\/Raf\/ERK","pathway","did","not","appear","to","mediate","the","effect","of","the","antioxidant","."],"ner_tags":[0,0,1,2,2,2,0,1,0,1,0,0,0,1,2,2,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18205","tokens":["Full-length","cDNAs","and","genomic","clones","were","isolated",",","and","the","gene","structure","was","determined.","Comparison","of","the","deduced","amino","acids","shows","88","%","sequence","identity","between","mouse","and","human","BOB.1\/OBF.1","."],"ner_tags":[0,1,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"771","tokens":["However",",","this","efficient","propagation","of","the","LTR-modified","tat","mutants","was","restricted","to","some","lymphoid","cell","lines","that","have","been","transformed","with","other","viruses","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0]}
{"id":"357","tokens":["METHODS","AND","RESULTS",":","Gel-shift","analyses","demonstrated","dose-dependent","inhibition","of","TNF","-induced","NF-kappa","B","mobilization","by","aspirin","at","concentrations","ranging","from","1","to","10","mmol\/L","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3984","tokens":["Furthermore",",","in","the","absence","of","exogenous","HGFs",",","FL","monocytic","progenitors","(","colony-forming","unit","monocyte","[","CFU-M","]",")","generate","large","colonies","exclusively","composed","of","monocytes-macrophages",";","these","colonies","are","absent","in","FCS-","clonogenic","culture","."],"ner_tags":[0,0,0,0,0,0,0,9,0,7,8,8,0,7,8,8,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11740","tokens":["The","characterization","of","these","proteins","in","human","primary","haemopoietic","cells","and","acute","myeloid","leukaemia","(","AML",")","blasts","may","thus","give","an","insight","to","the","molecular","mechanisms","governing","proliferation","and","leukaemogenesis","in","these","cells","."],"ner_tags":[0,0,0,0,0,0,7,8,8,8,0,7,8,8,8,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8153","tokens":["Bacterial","lipopolysaccharide","activates","nuclear","factor-kappaB","through","interleukin-1","signaling","mediators","in","cultured","human","dermal","endothelial","cells","and","mononuclear","phagocytes","."],"ner_tags":[0,0,0,9,10,0,9,10,10,0,5,6,6,6,6,0,7,8,0]}
{"id":"12582","tokens":["A","human","dendritic","cell-based","assay","used","to","monitor","a","T","cell","proliferation","response","to","viral","peptides","in","vitro","is","described","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10743","tokens":["In","THP-1","cells","and","in","normal","PBM",",","gamma-IFN","inhibits","1",",","25-","(","OH",")","2D3","induction","of","24-hydroxylase","mRNA","levels","without","reducing","mRNA","stability",",","suggesting","gamma-IFN","inhibition","of","1",",","25","(","OH",")","2D3","transactivating","function","."],"ner_tags":[0,5,6,0,0,0,7,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2669","tokens":["In","clonogenetic","fetal","calf","serum-supplemented","(","FCS+",")","or","-nonsupplemented","(","FCS-",")","culture","treated","with","saturating","levels","of","interleukin-3","(","IL-3",")","granulocyte-macrophage","colony-stimulating","factor","(","GM-CSF",")","and","erythropoietin","(","Ep",")","(","combined","with","c-kit","ligand","in","FCS","(","-",")","-culture","conditions",")",",","RA","induces","a","dramatic","dose-dependent","shift","from","erythroid","to","granulomonocytic","colony","formation",",","the","latter","colonies","being","essentially","represented","by","granulocytic","clones","."],"ner_tags":[0,5,6,6,6,6,6,6,6,6,6,6,6,6,0,0,0,0,0,9,0,9,0,9,10,10,0,9,0,0,9,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"12032","tokens":["Interestingly",",","CTLA4Ig","did","not","significantly","inhibit","the","activation","of","either","NF","of","activated","T","cells","(","NFAT",")","or","AP-1","reporters","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,9,0,0,1,2,0]}
{"id":"17075","tokens":["Transfections","of","E3","constructs","linked","to","the","chloramphenicol","acetyltransferase","gene","revealed","that","mutagenesis","of","the","distal","NF-kappa","B","motif","(","L2",")","had","minimal","effects","on","promoter","expression","in","HeLa","cells",",","but","resulted","in","dramatic","decreases","in","expression","by","lymphoid","cells","."],"ner_tags":[0,0,1,2,0,0,0,1,2,2,0,0,0,0,0,1,2,2,2,0,1,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"17342","tokens":["Int-2","was","amplified","in","13.1","%","and","c-myc","was","amplified","in","10.3","%","."],"ner_tags":[1,0,0,0,0,0,0,1,0,0,0,0,0,0]}
{"id":"15963","tokens":["Cortivazol","mediated","induction","of","glucocorticoid","receptor","messenger","ribonucleic","acid","in","wild-type","and","dexamethasone-resistant","human","leukemic","(","CEM",")","cells","."],"ner_tags":[0,0,0,0,3,4,4,4,4,0,5,0,5,6,6,6,6,6,6,0]}
{"id":"9677","tokens":["Surprisingly",",","G28-5","sFv","was","a","potent","CD40","agonist","that","rapidly","crosslinked","CD40","on","the","cell","surface","but","did","not","crosslink","CD40-Ig","in","solution","."],"ner_tags":[0,0,9,10,0,0,0,9,10,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"13521","tokens":["Transcription","of","a","minimal","promoter","from","the","NF-IL6","gene","is","regulated","by","CREB\/ATF","and","SP1","proteins","in","U937","promonocytic","cells","."],"ner_tags":[0,0,0,1,2,0,0,1,2,0,0,0,9,0,9,10,0,5,6,6,0]}
{"id":"17785","tokens":["Microtubules","mediate","cellular","25-hydroxyvitamin","D3","trafficking","and","the","genomic","response","to","1",",","25-dihydroxyvitamin","D3","in","normal","human","monocytes","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"12391","tokens":["Characterization","of","our","line","led","to","two","new","findings","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"5693","tokens":["The","identification","of","allelic","nucleotides",",","which","results","in","overexpression","of","the","IL-4","gene",",","provides","specific","targets","for","a","comprehensive","screening","of","atopic","and","nonatopic","individuals","and","may","provide","a","clue","for","genetic","predisposition","for","atopy","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12687","tokens":["Recently",",","the","transcription","factor","GATA-3","was","shown","to","be","selectively","expressed","in","Th2","but","not","Th1","cells","and","to","augment","Th2-specific","cytokines","."],"ner_tags":[0,0,0,9,10,9,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,9,10,0]}
{"id":"11361","tokens":["Although","CD40","lacks","intrinsic","tyrosine","kinase","activity",",","its","ligation","induces","protein","tyrosine","phosphorylation",",","which","is","necessary","for","several","CD40","-mediated","events","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"5889","tokens":["By","contrast",",","stimulation","of","calcium","influx",",","a","CD3","-dependent","event",",","paralleled","zap-70","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0]}
{"id":"5368","tokens":["In","this","study",",","we","used","the","T-cell-activating","superantigen","staphylococcal","enterotoxin","A","(","SEA",")","to","investigate","molecular","mechanisms","of","T-lymphocyte","anergy","in","vivo","."],"ner_tags":[0,0,0,0,0,0,0,9,10,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8110","tokens":["In","addition",",","expression","of","Fli-1","was","identified","immunohistochemically","in","megakaryocytes","derived","from","CD34","(","+",")","cells","treated","with","the","megakaryocyte","differentiation","and","proliferation","factor",",","thrombopoietin","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,7,0,0,7,8,8,8,8,0,0,0,9,10,10,10,10,0,9,0]}
{"id":"1022","tokens":["Expression","of","the","kappa","immunoglobulin","light","chain","gene","requires","developmental-","and","tissue-specific","regulation","by","trans-acting","factors","which","interact","with","two","distinct","enhancer","elements","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,1,2,0]}
{"id":"6781","tokens":["Furthermore",",","SLP-76","and","Vav","have","a","synergistic","effect","on","interleukin","(","IL",")","-2","promoter","activity","in","T","cells","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,1,2,2,2,2,2,0,0,5,6,0]}
{"id":"4841","tokens":["A","protein","footprint","was","visible","over","this","region","of","the","c-myb","5","'","flanking","sequence","in","activated","T","cells","but","not","in","unactivated","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,7,8,8,0,0,0,7,8,8,0]}
{"id":"16879","tokens":["We","also","find","that","NF-E2",",","another","trans-acting","factor","of","the","erythrocytic","lineage",",","is","present","in","megakaryocytes","."],"ner_tags":[0,0,0,0,9,0,0,9,10,0,0,7,8,0,0,0,0,5,0]}
{"id":"371","tokens":["Together",",","these","results","suggest","that","phosphorylation","of","I","kappa","B","alpha",",","mediated","through","both","the","TNF-alpha","-inducible","and","the","PP-2A-opposing","kinases",",","may","serve","to","target","I","kappa","B","alpha","for","proteasome","-mediated","degradation","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,9,10,10,10,0,9,0,0,0]}
{"id":"16691","tokens":["Northern","blot","analysis","of","polyadenylated","RNA","purified","from","activated","human","B","cells","revealed","a","single","mRNA","transcript","of","approximately","2.3","kb","."],"ner_tags":[0,0,0,0,3,4,0,0,7,8,8,8,0,0,3,4,4,0,0,0,0,0]}
{"id":"7032","tokens":["GR","binding","parameters","were","analyzed","in","relation","to","the","results","of","the","combined","dexamethasone","-CRH","test",",","which","reflects","corticosteroid","receptor","function","at","the","hypothalamus",",","in","30","patients","and","9","controls","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10022","tokens":["These","results","suggest","that","in","human","T","lymphocytes","IFN-beta","can","activate","other","transcription","factor","(","s",")","distinct","from","ISGF3","to","regulate","PLC","gamma","1","expression","."],"ner_tags":[0,0,0,0,0,7,8,8,9,0,0,0,9,10,0,0,0,0,0,9,0,0,9,10,10,0,0]}
{"id":"14399","tokens":["Taken","together",",","these","findings","suggest","that","vincristine","resistance","confers","insensitivity","to","TPA-induced","differentiation","and","can","include","defects","in","PKC","-mediated","signaling","events","and","induction","of","jun\/fos","early","response","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,1,2,2,2,0,0]}
{"id":"10063","tokens":["Differanisole","A","and","9-cis","retinoic","acid","(","9cisRA",")","synergistically","inhibited","the","growth","and","induced","functional","and","morphologic","differentiation","of","HL-60","and","NB4","cells",",","whereas","the","combined","treatment","with","differanisole","A","and","all-trans","retinoic","acid","or","1alpha",",","25-dihydroxyvitamin","D3","was","less","effective","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1352","tokens":["The","status","of","X","chromosome","inactivation","in","blood","leukocytes","from","obligate","carriers","of","XCID","was","determined","from","the","polymorphic",",","short","tandem","repeats","(","CAG",")",",","in","the","androgen","receptor","gene",",","which","also","contains","a","methylation-sensitive","HpaII","site","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,1,2,2,0]}
{"id":"14530","tokens":["Together",",","these","findings","suggest","that","one","function","of","c-Rel","is","as","a","physiologic","repressor","of","the","HIV-1","LTR","and","IL-2R","alpha","promoters",",","serving","to","efficiently","counter","the","strong","transcriptional","activating","effects","of","p65","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,1,2,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"7934","tokens":["In","addition",",","exogenous","p27","(","KIP1",")","expression","can","enhance","the","level","of","CD11b","antigen","in","myeloid","leukemic","cells","."],"ner_tags":[0,0,0,0,9,10,10,10,0,0,0,0,0,0,9,10,0,7,8,8,0]}
{"id":"18219","tokens":["Two-dimensional","phosphopeptide","maps","of","the","Ets-1","protein","from","cells","incubated","with","ionomycin","or","anti-IgM","contained","two","unique","phosphopeptides","that","were","absent","in","untreated","cells","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5264","tokens":["Viral","titres","were","10","(","4.4",")",",","10","(","6.1",")",",","10","(","5.2",")",",","and","10","(","2.9",")","pfu\/animal",",","on","days","1",",","3",",","4",",","and","7","after","infection",",","respectively","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1517","tokens":["The","constitutive","NF-kappa","B","appears","to","be","functionally","active",",","since","a","low","level","of","tumour","necrosis","factor","(","TNF",")","transcript","is","detectable","in","monocytes",",","and","this","level","can","be","increased","by","blocking","transcript","degradation","using","cycloheximide","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,3,4,4,4,4,4,4,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11481","tokens":["CTLs","from","BALB\/c","mice","inoculated","i.p.","with","wild-type","Ad","recognized","E1B","in","the","context","of","the","major","histocompatibility","complex","(","MHC",")","class","I","Dd","allele","and","a","region","outside","E1","associated","with","the","Kd","allele","."],"ner_tags":[7,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,0,0,0,0,1,0,0,0,1,2,0]}
{"id":"4310","tokens":["Interleukin-10","(","IL-10",")",",","like","IL-4",",","is","known","to","inhibit","cytokine","expression","in","activated","human","monocytes","."],"ner_tags":[9,0,9,0,0,0,9,0,0,0,0,0,9,0,0,7,8,8,0]}
{"id":"15934","tokens":["Only","the","activities","for","NF-AT","and","AP-1","sites","require","two","signals","for","optimal","induction",",","i.e.",",","PMA","plus","either","lectin","or","antibody","to","the","CD3","or","CD28","surface","molecules","."],"ner_tags":[0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,0,9,10,10,0]}
{"id":"13816","tokens":["These","data","demonstrate","that","DMDTC","is","a","potent","immunosuppressive","compound","in","vitro","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13843","tokens":["Transient","transfectants","of","the","porcine","B-cell","line","L23","with","the","mutated","CIITA","constructs","were","tested","for","the","suppression","of","constitutive","SLA-DR","and","SLA-DQ","expression","."],"ner_tags":[0,0,0,0,5,6,6,6,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4391","tokens":["By","using","70Z\/3-derived","pre-B-cell","lines","either","lacking","or","expressing","human","CD14","(","the","LPS","receptor",")",",","it","was","observed","that","expression","of","human","CD14","imparted","responsiveness","to","LPS","but","not","to","OspA","or","spirochetal","lipopeptides","(","assessed","by","induction","of","NF-kappa","B","and","expression","of","surface","immunoglobulin","M",")","."],"ner_tags":[0,0,5,6,6,0,0,0,0,9,10,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,9,0,9,10,0,0,0,0,0,9,10,0,0,0,9,10,10,0,0]}
{"id":"11612","tokens":["Overexpression","of","beta-adrenergic","receptor","kinase","1","carboxyl-terminal","peptide","in","JY25","cells","also","inhibited","Raf-1","and","ERK1","activity",",","indicating","a","direct","involvement","of","G","betagamma","subunits","in","the","signal","transduction","generated","through","activation","of","MAPK","pathway","by","TCC","assembly","in","the","plasma","membrane","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0]}
{"id":"8184","tokens":["RA","receptor","activation","appears","critical","to","regulating","important","aspects","of","hematopoiesis",",","since","transducing","a","COOH-terminally","truncated","RARalpha","exhibiting","dominant-negative","activity","(","RARalpha403",")","into","normal","mouse","bone","marrow","generates","hematopoietic","growth","factor-dependent","cell","lines","frozen","at","the","multipotent","progenitor","(","EML",")","or","committed","promyelocyte","(","MPRO",")","stages","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,9,0,0,0,0,0,0,0,5,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12153","tokens":["We","report","here","that","Stat6","interacts","with","three","binding","sites","in","the","human","IL-4","promoter","by","electrophoretic","mobility","shift","assays","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0]}
{"id":"11506","tokens":["One","of","these","subregions",",","NRE","gamma",",","is","active","in","both","HeLa","cervical","carcinoma","cells","and","Huh7","hepatoma","cells","and","was","found","to","be","bound","by","a","protein","factor","present","in","both","cell","types","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,5,6,6,6,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5298","tokens":["Recently",",","we","have","identified","a","repression","domain","located","within","the","N","terminus","of","Oct-2a","(","amino","acids","2-99",")","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,9,10,0,9,0,9,10,10,0,0]}
{"id":"7945","tokens":["Intercellular","adhesion","molecule-1","and","P-selectin-specific","monoclonal","antibodies","attenuated","the","increased","neutrophil","adhesion","during","both","phases",",","whereas","an","anti-E-selectin","monoclonal","antibody","also","attenuated","the","phase","2","response","."],"ner_tags":[9,10,10,0,9,10,10,0,0,0,7,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"10012","tokens":["When","studying","the","binding","of","SR","31747A","on","membranes","from","yeast","expressing","SR-BP",",","we","found","a","pharmacological","profile","of","sigma","1","receptors",";","binding","was","displaced","by","(","+",")","-pentazocine",",","haloperidol",",","and","(","+",")","-SKF","10",",","047",",","with","(","+",")","-SKF","10",",","047","being","a","more","potent","competitor","than","(","-",")","-SKF","10",",","047","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"54","tokens":["Two","of","these","are","potential","binding","sites","for","STAT","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8544","tokens":["Although","resting","Jurkat","cells","express","Fas",",","Fas","mRNA","was","induced","approximately","10-fold","in","2","h","upon","P\/I","stimulation","."],"ner_tags":[0,5,6,6,0,9,0,3,4,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4071","tokens":["A","critical","role","of","Sp1-","and","Ets-related","transcription","factors","in","maintaining","CTL-specific","expression","of","the","mouse","perforin","gene","."],"ner_tags":[0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,1,2,2,0]}
{"id":"4973","tokens":["Electrophoretic","mobility","shift","analyses","demonstrated","that","the","151-bp","region","contains","nuclear","protein","binding","sites","for","Sp1",",","PU.1",",","and\/or","Elf-1",",","and","a","novel","factor","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,1,2,2,2,0,9,0,9,0,0,9,0,0,0,9,10,0]}
{"id":"12191","tokens":["In","the","past","few","years",",","there","has","been","some","progress","in","defining","the","tyrosine","kinases","that","are","activated","by","the","IL-3\/IL-5\/GM-CSF","receptor","beta-subunit","in","eosinophils","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,7,0]}
{"id":"13400","tokens":["Despite","overwhelming","evidence","that","enhanced","production","of","the","p75","tumor","necrosis","factor","receptor","(","p75TNF-R",")","accompanies","development","of","specific","human","inflammatory","pathologies","such","as","multi-organ","failure","during","sepsis",",","inflammatory","liver","disease",",","pancreatitis",",","respiratory","distress","syndrome",",","or","AIDS",",","the","function","of","this","receptor","remains","poorly","defined","in","vivo","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11992","tokens":["These","findings","support","a","model","in","which","gamma","(","c",")","serves","primarily","to","activate","signal","transduction","by","the","IL-7R","complex",",","while","IL-7R","alpha","determines","specific","signaling","events","through","its","association","with","cytoplasmic","signaling","molecules","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,9,10,0,0,9,10,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"11148","tokens":["In","this","study","we","have","investigated","the","effect","of","FCM","on","the","LPS-induced","DNA-binding","activity","of","NF-kappaB",",","by","means","of","electrophoretic","shift","assay","(","EMSA",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16401","tokens":["The","C26","element","conferred","partial","responsiveness","to","p40tax","when","linked","to","one","copy","of","the","21-bp","element","that",",","by","itself",",","showed","little","activation","in","response","to","p40tax","."],"ner_tags":[0,1,2,0,0,0,0,9,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"4289","tokens":["Finally",",","TFIIA","facilitates","Tax","transactivation","in","vitro","and","in","vivo","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"14839","tokens":["Lytic","transition","of","Epstein-Barr","virus","(","EBV",")","is","initiated","by","distinct","immediate","early","regulators","of","the","viral","cycle",",","in","synchronization","to","temporary",",","permissive","conditions","during","host","cell","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4821","tokens":["Here","we","show","that","the","murine","PU.1","promoter","is","also","specifically","and","highly","functional","in","B","cell","lines","as","well","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,5,6,6,0,0,0]}
{"id":"14320","tokens":["Moreover",",","cyclosporine",",","at","concentrations","readily","accomplished","in","clinical","practice",",","was","found","to","inhibit","the","emergence","of","these","DNA-binding","proteins","in","normal","human","T","cells","signaled","via","cell","surface","proteins","implicated","in","antigen-dependent","T","cell","activation","and","in","T","cells","stimulated","by","mobilization","of","cellular","calcium","and","activation","of","protein","kinase","C","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"17477","tokens":["In","only","four","patients","sodium","in","HML","without","incubation","was","elevated","compared","with","the","range","for","normal","persons","."],"ner_tags":[0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5609","tokens":["IL-4","activates","gene","expression","by","inducing","tyrosine","phosphorylation",",","homodimerization",",","and","nuclear","translocation","of","the","latent","transcription","factor",",","STAT6","(","signal","transducer","and","activator","of","transcription-6",")","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,9,10,10,10,10,10,0,0]}
{"id":"8981","tokens":["Cytoplasmic","AR","do","not","translocate","to","the","nucleus","of","T","cells","in","the","presence","of","testosterone",",","in","contrast","to","cytoplasmic","AR","in","human","cancer","LNCaP","cells","."],"ner_tags":[9,10,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,9,10,0,5,6,6,6,0]}
{"id":"1510","tokens":["This","nuclear","NF-kappa","B","was","still","present","when","contaminant","LPS","was","removed","by","ultrafiltration","and","when","serum","was","omitted","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4177","tokens":["The","regulation","of","sialoadhesin","expression","was","mediated","by","the","GC","receptor",",","and","not","by","mineralocorticoid","receptor",",","as","shown","by","inhibition","experiments","with","specific","antagonists","."],"ner_tags":[0,0,0,9,0,0,0,0,0,9,10,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"17036","tokens":["Lymphocyte","cell","lines","from","vitamin","D-dependent","rickets","type","II","show","functional","defects","in","the","1","alpha",",","25-dihydroxyvitamin","D3","receptor","."],"ner_tags":[5,6,6,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"9444","tokens":["The","number","and","apparent","dissociation","constant","of","glucocorticoid","receptor","were","measured","using","a","whole-cell","binding","assay","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"15674","tokens":["Here","we","demonstrate","that","Bcl-3","can","aid","kappa","B","site","-dependent","transcription","in","vivo","by","counteracting","the","inhibitory","effects","of","p50\/NF-kappa","B","homodimers","."],"ner_tags":[0,0,0,0,9,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"6901","tokens":["Moreover",",","in","a","physiological","coculture","cellular","assay","system",",","we","show","that","membrane-bound","TNF-alpha","and","LT-alpha1beta2","act","virtually","identically","to","their","soluble","forms","in","the","regulation","of","HIV-1","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5189","tokens":["We","used","oligonucleotide","probes","from","the","beta-casein","and","IRF-1","gene","promoters","and","the","ISRE","probe","to","detect","STAT","proteins","in","nuclear","extracts","from","acute","leukemia","cells","in","bandshift","assays","."],"ner_tags":[0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,9,10,0,0,0,0,7,8,8,0,0,0,0]}
{"id":"9191","tokens":["HLA","binding","characteristics","and","generation","of","cytotoxic","lymphocytes","against","peptides","derived","from","oncogenic","proteins","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,9,10,0]}
{"id":"5445","tokens":["The","costimulatory","molecule","B7.1","provides","a","second","signal","critical","for","T","cell","activation","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"164","tokens":["Nonradioactive","quantification","of","glucocorticoid","receptor","expression","during","differentiation","of","human","monocytic","cells","(","U937",")","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,7,8,0,5,0,0]}
{"id":"11732","tokens":["Pretreatment","of","NK","cells","with","the","antioxidant","pyrrolidine","dithiocarbarmate","(","PDTC",")","leads","to","the","inhibition","of","NF-kappa","B","activation","but","the","AP-1","binding","to","DNA","was","superinduced","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,0,0,0,0,0,0]}
{"id":"17661","tokens":["These","observations","demonstrate","directly","that","there","is","de","novo","synthesis","of","NF-kappa","B","during","human","lymphocyte","activation","and","suggest","that","this","process","is","hormonally","regulated","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"548","tokens":["These","studies","identify","p21ras","as","a","target","of","the","same","cell","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0,0,0]}
{"id":"7012","tokens":["Exogenous","addition","of","transforming","growth","factor-beta",",","which","exerts","an","inhibitory","effect","on","some","monocytic","differentiation","markers",",","inhibited","macrophage","maturation",",","integrin","expression","and","STAT1","binding","activity","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"11421","tokens":["We","now","report","that","dimers","consisting","of","p50","NFkappaB1",",","p65","RelA",",","and\/or","c-Rel","are","present","in","neutrophils","and","that","the","greater","part","of","these","protein","complexes","is","physically","associated","with","cytoplasmic","IkappaB-alpha","in","resting","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,10,0,0,9,0,0,0,7,0,0,0,0,0,0,0,9,10,0,0,0,0,9,10,0,0,0,0]}
{"id":"10088","tokens":["The","intracellular","localization","of","NFkappaB","after","TNFalpha","simulation","was","determined","by","confocal","immunocytochemistry","using","an","anti-p65","antibody","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"14116","tokens":["METHODS","."],"ner_tags":[0,0]}
{"id":"6558","tokens":["Looking","back","at","successes","and","failures","in","newer","approaches","to","treating","IBD",",","it","is","tempting","--","although","still","difficult","--","to","draw","conclusions","about","pathogenesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2928","tokens":["TSC2","is","a","gene","on","chromosome","16p13.3","associated","with","the","autosomal","dominant","neurocutaneous","disorder",",","tuberous","sclerosis","complex","(","TSC",")","."],"ner_tags":[1,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9848","tokens":["Avian","erythroblasts","expressing","the","activated","mouse","EpoR","(","R129C",")","differentiated","into","erythrocytes","in","response","to","hEpo","."],"ner_tags":[7,8,0,0,9,10,10,10,10,10,0,0,7,0,0,0,9,0]}
{"id":"3155","tokens":["The","present","paper","reviews","the","data","supporting","a","new",",","two-step","model","for","non-genomic","and","genomic","aldosterone","effects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7178","tokens":["By","comparing","the","expression","of","genes","controlling","apoptosis",",","including","those","encoding","several","members","of","the","BCL-2","family","of","proteins",",","the","known","relative","resistance","of","EBV-immortalized","B-cell","lines","to","apoptosis","induced","by","low","serum","was","found","to","correlate","with","expression","of","both","BCL-2","and","A20","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"1485","tokens":["This","cell","line","should","be","a","very","useful","tool","for","the","investigation","of","both","megakaryocytic","and","erythroid","maturation","."],"ner_tags":[0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7591","tokens":["BACKGROUND",":","Studies","from","our","laboratory","have","shown","that","the","earliest","stages","of","atherosclerosis","may","be","mediated","by","an","autoimmune","reaction","against","heat","shock","protein","60","(","Hsp60",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0]}
{"id":"2982","tokens":["Lack","of","T-cell-mediated","recognition","of","the","fusion","region","of","the","pml\/RAR-alpha","hybrid","protein","by","lymphocytes","of","acute","promyelocytic","leukemia","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,7,0,0,0,0,0,0]}
{"id":"6400","tokens":["The","aim","of","this","study","was","to","examine","the","ability","of","tumor","necrosis","factor","alpha","(","TNFalpha",",","a","proinflammatory","cytokine",")","and","interleukin","(","IL",")","-10","(","an","anti-inflammatory","cytokine",")","to","differentially","regulate","the","sensitivity","of","human","monocytes","\/macrophages","to","glucocorticoids","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0,9,10,0,0,9,10,10,10,10,0,0,9,10,0,0,0,0,0,0,0,7,8,7,0,0,0]}
{"id":"17859","tokens":["The","B4-2","clone","coded","for","an","mRNA","of","2061","bp","in","length","."],"ner_tags":[0,1,0,0,0,0,3,0,0,0,0,0,0]}
{"id":"7504","tokens":["Our","findings","demonstrate","that","p38","MAPK","1",")","plays","an","important","role","in","signal","integration","during","costimulation","of","primary","mouse","T","cells",",","2",")","may","be","involved","in","the","induction","of","c-Jun","activation","and","augmentation","of","AP-1","transcriptional","activity",",","and","3",")","regulates","whether","T","cells","enter","a","state","of","functional","unresponsiveness","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"2997","tokens":["Interferon-gamma","(","IFN-gamma",")","is","produced","by","natural","killer","cells","and","certain","subsets","of","T","cells",",","but","the","basis","for","its","selective","expression","is","unknown","."],"ner_tags":[9,0,9,0,0,0,0,7,8,8,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6679","tokens":["We","have","now","investigated","the","mechanism","of","action","of","a","new","analogue","of","UP",",","PNU156804",",","which","shows","a","more","favorable","activity","profile","than","UP","in","mice","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1786","tokens":["We","have","cloned","the","gene","for","a","new","ets-related","transcription","factor",",","ERP","(","ets-related","protein",")",",","from","the","murine","pre-B","cell","line","BASC","6C2","and","from","mouse","lung","tissue","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,9,0,9,10,0,0,0,0,5,6,6,6,5,6,0,0,0,0,0,0]}
{"id":"12345","tokens":["In","this","system",",","simultaneous","exposure","to","CD40L","together","with","either","IL-4","or","IFN-gamma","does","not","lead","to","the","activation","of","novel","Rel\/STAT","complexes","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,9,0,9,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"6971","tokens":["A","well-studied","example","is","nuclear","factors","of","activated","T-cell","(","NFAT",")","sites","which","are","composite","elements","of","a","NFATp\/c","and","an","activating","protein","1","(","AP-1",")","binding","site","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0]}
{"id":"12735","tokens":["These","studies","investigate","the","relationship","between","leukocyte","populations",",","steroid","hormone","receptor","expression",",","proliferative","activity",",","bcl-2","expression","and","apoptosis","in","eutopic","and","ectopic","endometrium","from","women","with","endometriosis","or","adenomyosis","at","different","phases","of","the","menstrual","cycle","."],"ner_tags":[0,0,0,0,0,0,7,8,0,9,10,10,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15510","tokens":["This","is","most","likely","due","to","the","presence","of","the","lymphoid-specific","OTF-2","factor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"7451","tokens":["The","second","stage",",","development",",","we","propose","is","the","true","IL-12","induced","developmental","stage",",","involving","expression","of","Stat4","inducible","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"4203","tokens":["Using","a","PKC","-specific","inhibitor",",","GF109203X",",","or","PKC-depleted","T","cells",",","we","found","that","a","large","part","of","the","anti-CD3","-induced","ERK","activation","is","PKC","dependent","."],"ner_tags":[0,0,9,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,0,0]}
{"id":"17260","tokens":["The","increase","in","c-jun","and","EGR2",",","but","not","c-fos",",","mRNA","was","also","abrogated","by","cytochalasin","D","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0]}
{"id":"17011","tokens":["Furthermore",",","the","existence","of","estrogen","receptor","(","estrogen","binding","activity",")","was","examined","histochemically","in","39","cases","and","it","was","detected","in","8","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3509","tokens":["Interestingly",",","the","expression","level","of","p27Kip1","mRNA","was","maximal","in","resting","Go","T-cells","and","rapidly","declined","following","anti-CD3","activation","."],"ner_tags":[0,0,0,0,0,0,3,4,0,0,0,7,8,8,0,0,0,0,9,0,0]}
{"id":"5411","tokens":["In","co-transfection","experiments",",","the","galectin-3","promoter","was","significantly","up-regulated","by","expression","vectors","encoding","the","40-kd","Tax","protein",",","a","potent","transactivator","in","HTLV-I","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,1,2,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"5157","tokens":["The","mouse","mammary","tumor","virus","env","gene","contains","a","transcriptional","activator","(","META",")","that","can","control","transcription","of","the","adjacent","long","terminal","repeat","region","."],"ner_tags":[0,0,0,0,0,1,2,0,0,1,2,0,1,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"17173","tokens":["RNA","from","control","resting","cells","contained","low","to","undetectable","levels","of","c-jun",",","fibronectin","receptor",",","and","actin","mRNA","."],"ner_tags":[0,0,0,7,8,0,0,0,0,0,0,3,0,3,4,0,0,3,4,0]}
{"id":"8191","tokens":["However",",","the","histone","deacetylase","(","HDAC",")","inhibitor","trichostatin","A","readily","activates","an","RXR-RAR","reporter","construct","in","the","multipotent","EML","cells","but","not","in","the","committed","MPRO","promyelocytes",",","indicating","that","differences","in","HDAC-containing","repressor","complexes","in","these","two","closely","related","but","distinct","hematopoietic","lineages","might","account","for","the","differential","activation","of","the","RXR-RARalpha403","heterodimers","that","we","observed","at","these","different","stages","of","myeloid","development","."],"ner_tags":[0,0,0,9,10,10,10,10,10,0,0,0,0,0,1,2,2,0,0,0,7,8,0,0,0,0,0,7,8,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14827","tokens":["Tal-1","rearrangements","are","associated","with","nearly","30","%","of","human","T","acute","lymphoblastic","leukemia","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1206","tokens":["The","signaling","pathways","involving","PKC","activation",",","calcium","mobilization","and","ras","activation","combine","to","provide","the","necessary","components","for","production","of","IL-2","during","T","cell","activation","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"13311","tokens":["LNCaP","cells","treated","with","prostaglandin","E2","showed","neither","a","reduction","in","proliferation","nor","a","down-regulation","of","AR","and","PSA","levels","."],"ner_tags":[5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0]}
{"id":"10735","tokens":["The","hypercalcemia","of","various","granulomatoses","is","caused","by","endogenous","1",",","25-dihydroxyvitamin","D","[","1",",","25-","(","OH",")","2D3","]","overproduction","by","disease-activated","macrophages","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"176","tokens":["The","role","of","shared","receptor","motifs","and","common","Stat","proteins","in","the","generation","of","cytokine","pleiotropy","and","redundancy","by","IL-2",",","IL-4",",","IL-7",",","IL-13",",","and","IL-15","."],"ner_tags":[0,0,0,9,10,10,0,9,10,10,0,0,0,0,9,0,0,0,0,9,0,9,0,9,0,9,0,0,9,0]}
{"id":"455","tokens":["We","transfected","promoter-luciferase","reporter","plasmids","into","THP-1","cells","to","define","sequences","that","mediate","transcriptional","control","during","monocyte","differentiation","."],"ner_tags":[0,0,1,2,2,0,5,6,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13780","tokens":["This","suggested","that","Ro","09-2210","was","inhibiting","an","activator","of","AP-1","which","was","upstream","of","c-jun","and","downstream","of","ras","signaling","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,1,0,0,0,9,0,0]}
{"id":"18313","tokens":["The","changes","in","gene","expression","brought","about","by","gamma","interferon","are","thought","to","involve","transient","increases","in","the","activities","of","cellular","protein","tyrosine","kinases",",","including","the","Janus","kinases","Jak1","and","Jak2",",","leading","to","tyrosine","phosphorylation","of","the","transcription","factor","Stat1","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,9,10,9,0,9,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"1554","tokens":["These","results","suggest","that","CaM-K","II","may","exert","negative","influences","on","cytokine","gene","transcription","in","human","T","cells",",","and","provide","preliminary","evidence","for","negative","cross-talk","with","the","calcineurin-","and","PKC-","dependent","signaling","systems","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,1,2,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10133","tokens":["Despite","its","reported","role","as","a","negative","regulator","of","transcription",",","Ig\/EBP-1","appears","to","exert","a","stimulatory","effect","on","this","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,1,0]}
{"id":"10535","tokens":["IRF-2","gene","was","apparently","only","weakly","responsive","to","IFNs","in","these","cells","."],"ner_tags":[1,2,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"11384","tokens":["Cell-to-cell","contact","activation","of","NF-kappaB","was","only","partially","inhibited","by","100","microM","pyrrolidine","dithiocarbamate","and","was","not","correlated","with","a","significant","decrease","of","cellular","inhibitor","kappaB","alpha","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"17891","tokens":["This","novel","enzyme","is","distinct","from","E6-AP",",","the","p53-conjugating","ligase",",","and","from","E3","alpha",",","the","``","N-end","rule","''","ligase","."],"ner_tags":[0,0,0,0,0,0,9,0,0,9,10,0,0,0,9,10,0,0,9,10,10,10,10,0]}
{"id":"9991","tokens":["1.","In","this","study","we","hypothesized","that","in","individuals","with","certain","genetic","makeup",",","MTBE",",","benzene","or","their","metabolites","act","as","adducts","and","may","induce","programmed","cell","death","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17876","tokens":["Up-regulation","of","high-affinity","dehydroepiandrosterone","binding","activity","by","dehydroepiandrosterone","in","activated","human","T","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"16228","tokens":["The","addition","of","TGF-beta","to","human","B","lymphocyte","cultures","stimulated","with","Staphylococcus","aureus","Cowan","strain","I","and","IL-2","completely","inhibited","B","cell","Ig","secretion","(","greater","than","90","%",")","and","decreased","B","cell","surface","IgM",",","IgD",",","kappa","L","chain",",","and","lambda","L","chain","expression","."],"ner_tags":[0,0,0,9,0,5,6,6,6,0,0,0,0,0,0,0,0,9,0,0,7,8,9,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15372","tokens":["This","low","frequency","of","response","was","no","different","from","that","previously","detected","using","cultures","of","T","cells","and","autologous","dendritic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,8,8,0]}
{"id":"11224","tokens":["We","show","here","by","mobility-shift","assay","that","E2F-containing","DNA-binding","complexes","were","detected","in","HTLV-I-infected","T-cell","lines","and","leukemic","cells","obtained","from","ATL","patients","but","not","in","an","uninfected","T-cell","line",",","Jurkat",",","and","normal","peripheral","blood","mononuclear","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,0,5,6,6,0,7,8,0,0,0,0,0,0,0,0,5,6,6,0,5,0,0,7,8,8,8,8,0]}
{"id":"1807","tokens":["Both","constitutively","active","forms","of","CN","and","protein","kinase","C","(","PKC",")","synergistically","activated","transcription","from","the","GM-CSF","promoter","."],"ner_tags":[0,0,0,0,0,9,0,9,10,10,0,9,0,0,0,0,0,0,1,2,0]}
{"id":"4846","tokens":["In","addition",",","an","antibody","against","NFAT","did","not","cross-react","with","the","CMAT","protein","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,9,10,0]}
{"id":"8484","tokens":["We","thus","conclude","that","the","NF-Y","A","subunit","plays","a","relevant","role","in","activating","transcription","of","genes","highly","expressed","in","mature","monocytes","."],"ner_tags":[0,0,0,0,0,9,9,10,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"13943","tokens":["Interestingly",",","the","combination","of","the","RAR-selective","antagonist","and","9-cis","RA","resulted","in","partial","differentiation","and","apoptosis","of","HL-60","and","NB4","cells",",","whereas","the","RAR","antagonist","completely","blocked","all-trans","RA-induced","differentiation","and","apoptosis","of","the","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"840","tokens":["However",",","no","combination","of","CBF","alpha","and","CBF","beta","subunits","that","we","tested","was","able","to","distinguish","the","1-bp","difference","in","transcription","assays","."],"ner_tags":[0,0,0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9222","tokens":["The","expression","of","an","active","PKB","is","sufficient","to","induce","E2F","activity","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,9,0,0]}
{"id":"14331","tokens":["No","upregulation","of","megakaryocyte","or","lymphoid","markers","occurred","."],"ner_tags":[0,0,0,9,10,10,10,0,0]}
{"id":"17779","tokens":["Analysis","of","the","expression","of","human","I","kappa","B","alpha","protein","in","stable","transfectants","of","mouse","70Z\/3","cells","shows","that",",","as","for","the","endogenous","murine","protein",",","exogenous","I","kappa","B","alpha","is","degraded","in","response","to","inducers","of","NF-kappa","B","activity",",","such","as","phorbol","myristate","acetate","or","lipopolysaccharide","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"9507","tokens":["Analysis","of","interactions","between","huGATA-3","transcription","factor","and","three","GATA","regulatory","elements","of","HIV-1","long","terminal","repeat",",","by","surface","plasmon","resonance","."],"ner_tags":[0,0,0,0,9,0,0,0,0,1,2,2,0,1,2,2,2,0,0,0,0,0,0]}
{"id":"16539","tokens":["Upon","cotransfection","into","non-T","cells",",","TCF-1","could","transactivate","through","its","cognate","motif","."],"ner_tags":[0,0,0,7,8,0,9,0,0,0,0,0,0,0]}
{"id":"12096","tokens":["In","addition",",","lack","of","natural","killer","cells","and","selective","defects","in","gamma","delta","T","cells","and","dendritic","antigen-presenting","cells","point","to","Ikaros","as","an","essential","factor","for","the","establishment","of","early","branchpoints","of","the","T","cell","pathway","."],"ner_tags":[0,0,0,0,0,7,8,8,0,0,0,0,7,8,8,8,0,7,8,8,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10477","tokens":["To","approach","this",",","we","generated","a","luciferase","reporter","construct","containing","elements","of","the","CD95","ligand","promoter","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,0,0,0,0,9,10,0,0]}
{"id":"8710","tokens":["By","isolating","Daudi","x","HeLa","heterokaryons","a","few","hours","after","fusion",",","we","have","studied","the","initial","fate","of","two","B","cell-specific","transcription","factors","involved","in","Ig","gene","transcription",",","Oct-2","and","NF-kappa","B","."],"ner_tags":[0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,1,2,0,0,1,0,9,10,0]}
{"id":"17550","tokens":["The","transcription","of","the","human","immunodeficiency","virus","type","1","(","HIV-1",")","is","under","the","control","of","cellular","proteins","that","bind","to","the","viral","long","terminal","repeat","(","LTR",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,1,2,2,2,0,1,0,0]}
{"id":"10775","tokens":["An","enhancer-blocking","element","between","alpha","and","delta","gene","segments","within","the","human","T","cell","receptor","alpha\/delta","locus","."],"ner_tags":[0,1,2,0,1,2,2,2,2,0,0,1,2,2,2,2,2,0]}
{"id":"8254","tokens":["Cbl-b","undergoes","rapid","tyrosine","phosphorylation","upon","stimulation","of","the","TCR","and","cytokine","receptors","[","8","]","[","9","]","."],"ner_tags":[9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"8085","tokens":["In","typical","AITL",",","some","neoplastic","cells","were","positive","for","Bcl-6",",","showing","variable","degrees","of","staining","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"1667","tokens":["NAD","(","P",")","H",":","quinone","reductase","(","QR",")","is","known","to","protect","against","BQ","toxicity","."],"ner_tags":[9,10,10,10,10,10,10,10,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"11492","tokens":["Understanding","the","cis-","and","transacting","factors","that","regulate","the","tissue-specific","expression","of","PECAM-1","should","increase","our","understanding","of","the","mechanisms","by","which","vascular-specific","gene","expression","is","achieved","."],"ner_tags":[0,0,9,10,10,10,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1435","tokens":["However",",","the","p65","subunit","was","COOH-terminally","truncated",",","as","shown","by","immunoprecipitation","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"8648","tokens":["Two","variants","of","the","IL-4R","alpha-chain","(","IL-4Ralpha",")","gene","have","been","recently","identified","in","association","with","different","atopic","disorders","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17926","tokens":["We","present","evidence","that","IBR","and","IBF","are","most","likely","identical","proteins",",","differing","in","their","degree","of","glycosylation","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6258","tokens":["Heat","shock","induces","HIV-1","replication","in","chronically","infected","promyelocyte","cell","line","OM10.1","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"11888","tokens":["Physical","interactions","between","Ets","and","NF-kappaB\/NFAT","proteins","play","an","important","role","in","their","cooperative","activation","of","the","human","immunodeficiency","virus","enhancer","in","T","cells","."],"ner_tags":[0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,7,8,0]}
{"id":"9527","tokens":["These","results","demonstrate","that","RXR-alpha","has","a","role","in","mediating","growth","inhibition","and","cell","adhesion","during","myelomonocytic","differentiation",",","and","suggest","that","different","species","of","heterodimers","involving","RXR-alpha","may","control","the","acquisition","of","different","features","of","mature","monocyte\/macrophage","function","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17029","tokens":["Nuclear","3",",","5",",","3'-triiodothyronine","receptors","(","T3R",")","of","circulating","human","lymphocytes","in","hyper-","and","hypothyroidism","and","nonthyroidal","diseases","."],"ner_tags":[0,9,10,10,10,10,10,0,9,0,0,7,8,8,0,0,0,0,0,0,0,0]}
{"id":"14899","tokens":["The","effect","was","abrogated","by","the","PKC","inhibitor","staurosporine",",","suggesting","a","role","for","PKC","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"15100","tokens":["The","biological","activity","of","11","alpha-methyl-1","alpha",",","25-","(","OH",")","2D3","closely","resembled","that","of","the","natural","hormone","on","normal","and","leukemic","cell","proliferation","and","bone","resorption",",","whereas","its","in","vivo","effect","on","calcium","metabolism","of","the","rachitic","chick","was","about","50","%","of","that","of","1","alpha",",","25-","(","OH",")","2D3","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8539","tokens":["Activation-dependent","transcriptional","regulation","of","the","human","Fas","promoter","requires","NF-kappaB","p50-p65","recruitment","."],"ner_tags":[0,0,0,0,0,1,2,2,0,9,10,0,0]}
{"id":"17579","tokens":["Radioreceptor","assay","of","some","corticosteroid","derivatives","in","human","mononuclear","leukocytes","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,0]}
{"id":"17140","tokens":["Each","binding","site","contributes","to","the","overall","activity","of","the","enhancer",",","however","no","single","element","seems","absolutely","required","for","activity","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12800","tokens":["These","results","demonstrate","that","the","human","LOX-1","gene","is","a","new","member","of","the","natural","killer","gene","complex","with","a","unique","expression","profile","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0]}
{"id":"10672","tokens":["In","contrast",",","several","mutant","p85","alleles","had","dramatic","effects","on","NFAT","activation","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,9,0,0]}
{"id":"3040","tokens":["Pentoxifylline","for","the","treatment","of","infection","with","human","immunodeficiency","virus","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2479","tokens":["The","increases","in","AP-1","enhancer","activity","induced","by","PA","or","anti-CD3","mAb","were","efficiently","abrogated","by","the","presence","of","propranolol",",","an","inhibitor","of","PA","phosphohydrolase","and","protein","kinase","C","(","PKC",")","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,10,0,9,0,0]}
{"id":"17987","tokens":["Functional","analysis","of","5","'","deletion","constructs","in","transfected","K562","cells","and","gel","mobility","shift","localized","the","major","phorbol","ester-responsive","motifs","in","the","thromboxane","receptor","gene","promoter","to","a","cluster","of","activator","protein-2","(","AP-2",")","binding","consensus","sites","located","approximately","1.8","kb","5","'","from","the","transcription","initiation","site","."],"ner_tags":[0,0,0,1,2,2,2,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"11939","tokens":["Both","FMLP","and","PAF","activated","MAP","kinase","kinase-3","(","MKK3",")",",","a","known","activator","of","p38","MAPk","."],"ner_tags":[0,9,0,9,10,10,10,10,0,9,0,0,0,0,0,0,9,10,0]}
{"id":"14555","tokens":["Measurement","of","GR","mRNA","turnover","in","6TG1.1","cells","treated","with","actinomycin-D","revealed","a","half-life","of","2.5","h",",","which","was","unaffected","by","dexamethasone","treatment","."],"ner_tags":[0,0,3,4,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16303","tokens":["Comparison","of","a","nearly","full-length","cDNA","sequence","with","the","corresponding","genomic","sequence","reveals","one","small","intron","and","an","open","reading","frame","in","the","second","exon","."],"ner_tags":[0,0,0,1,2,2,2,0,0,0,1,2,0,0,0,0,0,0,1,2,2,0,0,0,1,0]}
{"id":"14835","tokens":["In","immature","hematopoietic","cells",",","tal-1","and","GATA-1","genes","are","coexpressed","in","committed","progenitors","cells","(","CD34+\/CD38","(","2+",")",")",",","whereas","they","are","not","detectable","in","the","most","primitive","cells","(","CD34","(","2+",")","\/CD38-",")","."],"ner_tags":[0,7,8,8,0,1,2,2,2,0,0,0,7,8,8,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,7,8,0,5,6,6,6,6,0,0]}
{"id":"14951","tokens":["Incubation","of","endothelial","cells","with","MM-LDL","caused","a","173","%","increase","in","intracellular","cAMP","levels","."],"ner_tags":[0,0,7,8,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"8976","tokens":["Binding","of","the","plasma","membrane","impermeable","testosterone-BSA","conjugate","induces","a","rapid","rise","(","<","5","s",")","in","[","Ca2+","]","i","of","Fura-2-loaded","T","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"3629","tokens":["Here",",","we","show","that","zinc","addition","in","a","serum-","and","lipopolysaccharide-free","cell","culture","system","leads","to","significantly","enhanced","levels","of","interleukin","1","beta","(","IL-1","beta",")","and","tumour","necrosis","factor","alpha","(","TNF-alpha",")","and","to","expression","of","the","corresponding","mRNA","in","human","peripheral","blood","mononuclear","cells","(","PBMC",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,0,0,9,10,10,10,0,9,0,0,0,0,0,0,0,3,0,7,8,8,8,8,0,7,0,0]}
{"id":"4679","tokens":["Disruption","of","the","PEBP2\/CBF","site","markedly","diminished","the","role","of","the","PEBP2\/CBF","factors","in","the","constitutive","transcription","of","the","CD36","gene","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,9,10,0,0,0,0,0,0,1,2,0]}
{"id":"13506","tokens":["5'HS3","contains","six","G-rich","motifs","that","are","essential","for","its","activity","."],"ner_tags":[1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12876","tokens":["Together",",","these","findings","support","the","notion","that","chromatin","configuration","as","well","as","the","interplay","of","promoter","elements","mediate","proper","hormone-dependent","and","tissue-specific","expression","of","the","B1","vitellogenin","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"3038","tokens":["CD40","-mediated","fra-1","induction","did","require","tyrosine","kinase","activity","."],"ner_tags":[9,0,1,0,0,0,9,10,0,0]}
{"id":"8225","tokens":["The","current","study","clearly","demonstrates","that","IL-2","does","not","induce","I","kappa","B","alpha","degradation","or","NF-kappa","B","activation","in","primary","human","T","cells","that","respond","to","IL-2","by","entering","the","cell","cycle","and","avoiding","apoptosis","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,9,10,10,0,0,0,9,10,0,0,7,8,8,8,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"15791","tokens":["Little","effect","was","observed","with","50-kDa","forms","of","p105","NF-kappa","B","or","rel",",","in","combination","with","p65","or","full-length","c-rel",",","which","do","not","stimulate","the","HIV","enhancer","in","these","cells","."],"ner_tags":[0,0,0,0,0,9,10,0,9,9,10,0,9,0,0,0,0,9,0,9,10,0,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"13893","tokens":["MLL","and","CALM","are","fused","to","AF10","in","morphologically","distinct","subsets","of","acute","leukemia","with","translocation","t","(","10",";","11",")",":","both","rearrangements","are","associated","with","a","poor","prognosis","."],"ner_tags":[0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"2568","tokens":["As","a","functional","correlate","of","this","finding",",","transient","co-transfection","of","HIV-1","LTR","reporter","constructs","in","a","different","T","cell","line","demonstrated","that","v-src","activated","this","promoter","in","a","kappa","B-dependent","manner","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,5,6,6,0,0,1,0,0,9,0,0,0,0,0,0]}
{"id":"4743","tokens":["We","have","shown","that","1-","(","5-chloronaphthalene-1-sulfonyl",")","-1H-hexahydro-1",",","4-diazepine","hydrochloride","(","ML-9",")",",","an","inhibitor","of","myosin","light","chain","kinase",",","induces","differentiation","of","monocytoid","leukemia","cell","lines","U937","and","THP-1","but","not","of","myeloblastic","leukemic","ML-1","cell","or","erythroleukemia","K562","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,5,6,6,6,5,0,5,0,0,0,5,6,6,6,0,5,6,6,0]}
{"id":"3926","tokens":["Native","PTF","beta",",","in","either","protein","fractions","or","a","PTF-Oct-1-DNA","complex",",","can","be","recognized","by","polyclonal","antibodies","raised","against","recombinant","PTF","beta","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,0,0,9,10,10,0]}
{"id":"5524","tokens":["No","correlation","was","found","between","estrogen","and","progesterone","status",",","tumor","size","and","polyamine","concentrations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9232","tokens":["TRADD","was","the","only","protein","that","interacted","with","wild-type","TES2","and","not","with","isoleucine-mutated","TES2","."],"ner_tags":[9,0,0,0,0,0,0,0,9,10,0,0,0,9,10,0]}
{"id":"12069","tokens":["To","analyze","the","effects","of","ectopic","expression","of","spi-1","on","the","proliferation\/differentiation","of","human","myeloid","leukemia","cells",",","K562","cells","were","stably","transfected","with","a","spi-1","expression","vector","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,7,8,8,8,0,5,6,0,0,0,0,0,1,2,2,0]}
{"id":"17583","tokens":["Treatment","of","10","with","warm","HCl","furnished","19-chloro-4",",","21-dihydroxypregna-4",",","9","(","11",")","-diene-3",",","20-dione","(","13",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16078","tokens":["We","found","that","the","relative","efficiency","of","the","enhancers","is","approximately","the","same",",","irrespective","of","the","type","of","promoter","used",",","i.e.",",","there","was","no","strong","preference","for","any","given","enhancer\/","promoter","combination","."],"ner_tags":[0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0]}
{"id":"5143","tokens":["Like","IkappaBalpha",",","Tax","-mediated","breakdown","of","IkappaBbeta","in","transfected","T","lymphocytes","is","blocked","either","by","cell-permeable","proteasome","inhibitors","or","by","mutation","Of","IkappaBbeta","at","two","serine","residues","present","within","its","N-terminal","region","."],"ner_tags":[0,9,0,9,0,0,0,9,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0]}
{"id":"6459","tokens":["A","significant","(","P","<","0.001","and","<","0.05",",","respectively",")","increase","in","the","percentage","of","cells","with","nuclear","staining","was","seen","in","the","lining","layer",",","compared","to","cells","in","the","sublining","region",",","in","rheumatoid","and","osteoarthritis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15324","tokens":["T3SO4","had","no","thyromimetic","effect","on","the","activity","of","Ca","(","2+",")","-ATPase","in","human","erythrocyte","membranes","at","doses","up","to","10",",","000","times","the","maximally","effective","dose","of","T3","(","10","(","-10",")","mol\/L",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10947","tokens":["Although","the","CD8+","cytotoxic","T","lymphocyte","(","CTL",")","response","to","latently","infected","cells","is","well","characterized",",","very","little","is","known","about","T","cell","controls","over","lytic","infection",";","this","imbalance","in","our","understanding","belies","the","importance","of","virus-replicative","lesions","in","several","aspects","of","EBV","disease","pathogenesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16558","tokens":["However",",","longer","periods","of","incubation","were","associated","with","a","return","to","the","distribution","of","PKC","in","control","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"3832","tokens":["The","purpose","of","this","review","is","to","show","how","the","accumulation","of","various","biochemical","lesions","with","advancing","age","leads","to","the","failure","of","a","critical","cell","function",",","namely","the","activation-induced","lymphocyte","proliferation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16888","tokens":["The","latter","one","appears","to","be","mediated","by","a","rapidly","calcium-dependent","induced","gene","product","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"10315","tokens":["Here","we","discuss","recent","advances","in","transcriptional","regulation","during","myelopoiesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14965","tokens":["Cytokines",",","the","peptide","hormones","which","control","the","homeostasis","of","the","immune","system","and","also","play","a","fundamental","role","in","inflammatory","and","immune","mediated","reactions",",","have","been","involved","at","multiple","levels","in","the","pathogenesis","of","the","acquired","immune","deficiency","syndrome","(","AIDS",")","."],"ner_tags":[9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10417","tokens":["NAC","caused","an","expected","dramatic","increase","in","the","reduced","glutathione","(","GSH",")","levels","in","EC","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"18397","tokens":["The","extent","of","IFN","-induced","NK","cell","killing","of","E1A-expressing","cells","was","proportional","to","the","level","of","E1A","expression","and","correlated","with","the","ability","of","E1A","to","block","IFN","-stimulated","gene","expression","in","target","cells","."],"ner_tags":[0,0,0,9,0,0,0,0,0,5,6,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,7,8,0]}
{"id":"8143","tokens":["We","utilized","CoCl2","as","a","mimetic","molecule","for","hypoxia","to","study","cellular","signaling","pathways","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3145","tokens":["These","findings","suggest","that","there","is","no","primary","and","general","impairment","of","glucocorticoid","metabolism","in","the","asthmatics",",","but","the","number","of","GCR","in","the","asthmatics","is","lower","than","that","in","healthy","controls","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"763","tokens":["Tat","is","an","essential","regulatory","protein","for","the","replication","of","human","immunodeficiency","virus","(","HIV",")","."],"ner_tags":[9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4301","tokens":["Our","results","demonstrate","the","regulation","of","STAT","activity","by","a","signaling","pathway","that","regulates","the","T","cell","functional","phenotype","and","is","distinct","from","the","cytokine","-activated","Janus","kinase","-STAT","signaling","pathway","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,9,0,0,0]}
{"id":"2717","tokens":["PML","is","expressed","in","diverse","tissues","and","cell","lines","and","localized","in","the","nucleus","with","a","typical","speckled","pattern","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10859","tokens":["Disruption","of","the","Jak1-binding","proline-rich","Box1","region","of","IL-4Ralpha","abolished","signaling","by","this","chimeric","receptor","."],"ner_tags":[0,0,0,9,10,10,10,0,9,0,0,0,0,9,10,0]}
{"id":"908","tokens":["To","identify","other","factors","which","interact","with","the","LMP-1","EBNA-2","response","element","(","E2RE",")",",","a","-236\/-145","minimal","E2RE","was","used","as","a","probe","in","an","electrophoretic","mobility","shift","assay","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,0,1,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11952","tokens":["The","putative","promoter","area","is","similar","to","those","of","several","other","myeloid-cell-specific","genes","in","that","it","contains","no","TATAAA","box","but","has","a","number","of","purine-rich","stretches","with","multiple","sites","for","the","factors","of","the","Ets","family","of","transcriptional","regulators","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,9,10,0,9,10,0]}
{"id":"2372","tokens":["Furthermore","the","number","of","binding","sites","determined","using","[","3H","]","dihydrotestosterone",",","[","3H","]","RU-1881",",","or","[","3H","]","testosterone","were","comparable","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8439","tokens":["DG","and","GG","were","synthesized","using","3-methylcholanthrene-induced","rat","liver","microsomes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11397","tokens":["Differentiation","of","U-937","promonocytic","cells","by","etoposide","and","ICRF-193",",","two","antitumour","DNA","topoisomerase","II","inhibitors","with","different","mechanisms","of","action","."],"ner_tags":[0,0,5,6,6,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"1979","tokens":["Moreover",",","its","rapid","activation","suggests","it","may","have","a","wider","role","within","signal","transduction","cascades","in","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"12843","tokens":["We","have","investigated","the","signal","transduction","pathway","from","Fc","receptors","that","leads","to","gene","activation","and","production","of","cytokines","in","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,7,0]}
{"id":"11717","tokens":["The","capacity","of","Syk","to","reconstitute","the","MAPK","response","required","the","catalytic","activity","of","Syk",",","an","intact","autophosphorylation","site","(","Y518","and","Y519",")",",","both","Src","homology","2","domains","and","it","was","blocked","by","the","inhibitory","N17-mutated","dominant-negative","Ras","construct","."],"ner_tags":[0,0,0,9,0,0,0,9,0,0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"16689","tokens":["Cloning","of","a","human","homeobox","gene","that","resembles","a","diverged","Drosophila","homeobox","gene","and","is","expressed","in","activated","lymphocytes","."],"ner_tags":[0,0,0,1,2,2,0,0,0,1,2,2,2,0,0,0,0,0,7,0]}
{"id":"9792","tokens":["Analysis","of","CD40","cytoplasmic","domain","truncation","and","point","mutants","defined","a","10-amino","acid","CD40","cytoplasmic","signaling","determinant","required","for","NF-kappa","B","activation","."],"ner_tags":[0,0,9,10,10,0,0,0,0,0,0,9,10,10,10,10,10,0,0,9,10,0,0]}
{"id":"909","tokens":["The","previously","characterized","factors","J","kappa",",","PU.1",",","and","AML1","bind","to","the","LMP-1","E2RE",",","along","with","six","other","unidentified","factors","(","LBF2","to","LBF7",")","."],"ner_tags":[0,0,0,0,9,10,0,9,0,0,9,0,0,0,1,2,0,0,0,0,0,0,0,0,9,0,9,0,0]}
{"id":"4692","tokens":["A","result","of","this","activation","process","is","the","induction","of","a","number","of","genes",",","including","those","encoding","cytokines","such","as","interleukin-2",",","tumor","necrosis","factor-alpha",",","and","interferon","(","IFN",")","-gamma","which","have","important","immunoregulatory","effects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,9,10,10,0,0,9,10,10,10,10,0,0,0,9,0,0]}
{"id":"2244","tokens":["The","human","and","mouse","GATA3","transcription","units","start","at","a","major","initiation","site","."],"ner_tags":[0,1,2,2,2,2,2,0,0,0,1,2,2,0]}
{"id":"17113","tokens":["Both","proteins","impart","cAMP-regulated","transcriptional","activity","to","a","heterologous","DNA-binding","domain",",","showing","that","cAMP","directly","modulates","the","transcriptional","stimulatory","activity","of","CREB","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"10877","tokens":["Studies","of","the","mechanisms","that","enable","EBV","to","infect","nonactivated",",","noncycling","B","cells","provide","compelling","evidence","for","a","sequence","of","events","in","which","EBV","binding","to","CD21","on","purified","resting","human","B","cells","rapidly","activates","the","NF-kappaB","transcription","factor",",","which",",","in","turn",",","binds","to","and","mediates","transcriptional","activation","of","Wp",",","the","initial","viral","latent","gene","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,8,8,0,0,0,9,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"6643","tokens":["These","findings","suggest","either","low","level","of","activation","is","required","or","that","different","caspases","are","involved","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"1582","tokens":["We","generated","conditional","EBV","mutants","by","expressing","EBNA2","as","chimeric","fusion","protein","with","the","hormone","binding","domain","of","the","estrogen","receptor","on","the","genetic","background","of","the","virus","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,10,10,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"102","tokens":["Furthermore",",","both","transforming","growth","factor-beta","and","genistein",",","a","tyrosine","kinase","inhibitor",",","could","suppress","IL-2","and","IL-12","signaling","but","CsA","was","generally","inactive","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"11046","tokens":["Western","and","supershift","analyses","indicated","that","functional","Jun","and","Fos","proteins","were","present","in","nuclear","extracts","of","PMA-differentiated","U937","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,5,6,6,0]}
{"id":"10568","tokens":["PO-B","was","originally","characterized","as","a","transcriptional","regulatory","factor","of","the","pro-opiomelanocortin","(","POMC",")","gene",";","however",",","it","has","become","increasingly","clear","that","this","protein","may","be","active","in","tissues","outside","the","pituitary",",","since","it","is","present","in","diverse","cell","types",",","including","differentiated","HL-60","promyelocytic","leukemia","cells","."],"ner_tags":[9,0,0,0,0,0,9,10,10,0,0,1,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"13845","tokens":["RESULTS",":","In","preliminary","studies",",","we","demonstrated","that","transfection","of","the","PIEC","line","with","full-length","human","CIITA","constructs","resulted","in","strong","expression","of","SLA-DR","and","SLA-DQ","antigens",",","thus","establishing","the","cross-species","effectiveness","of","human","CIITA","in","the","pig","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,1,2,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"6156","tokens":["Energy","substrates",",","hormone","responses","and","glucocorticoid","binding","in","lymphocytes","during","intense","physical","exercise","in","humans","following","phosphocreatine","administration","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"15156","tokens":["We","investigated","the","clinical","significance","of","glucocorticoid","receptor","determination","in","20","patients","with","systemic","lupus","erythematosus","(","SLE",")","who","afterwards","developed","nephrotic","syndrome","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3028","tokens":["In","exerting","their","antiproliferative","effects",",","GCS","diffuse","into","target","cells","where","they","bind","their","cytoplasmic","receptor",",","which","in","turn","translocates","to","the","nucleus","where","it","inhibits","transcription","of","cytokine","genes","through","direct","binding","to","the","glucocorticoid","response","elements","(","GRE",")",",","which","are","located","in","the","promoter","region","of","cytokine","genes","or",",","alternatively",",","through","antagonism","of","the","action","of","transcription","factors","required","for","optimal","transcriptional","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,1,2,2,0,1,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"12124","tokens":["We","conclude","that","the","low","levels","of","serum","1",",","25","(","OH",")","2D3","of","uremia","are","not","responsible","for","the","decrease","in","VDR","concentration","found","in","these","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"8246","tokens":["Furthermore",",","the","phosphorylation","status","of","TRAF2","had","significant","effects","on","the","ability","of","the","protein","to","bind","to","CD40",",","as","evidenced","by","our","observations","that","the","CD40","cytoplasmic","domain","interacted","preferentially","with","underphosphorylated","TRAF2","and","that","phosphatase","treatment","significantly","enhanced","the","binding","of","TRAF2","to","CD40","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,9,0,0,9,0,0,0,0,0,0,9,0,9,0]}
{"id":"6590","tokens":["Characterization","of","both","TCR","chains","documented","a","great","diversity","among","those","clones","and","the","persistence","of","clonotypes","over","a","2-yr","period","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6985","tokens":["These","results","indicate","that","the","presence","of","the","codon-10-variant","type","is","not","a","characteristic","of","breast","cancer","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0]}
{"id":"3825","tokens":["Aging","is","classically","accompanied","by","a","dysregulation","of","the","immunologic","machinery","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14222","tokens":["Mitogen-mediated","transcriptional","activation","of","the","CAT","gene","in","this","construct","was","inhibited","in","Nef-expressing","cells","but","not","in","control","cells","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,5,6,0,0,0,0,0,0]}
{"id":"6585","tokens":["These","properties","of","NF-ATc\/B","and","-C","might","be","of","importance","for","gene","regulation","in","naive","T","lymphocytes","in","which","NF-ATc\/B","and","-C","are","predominantly","synthesized","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,0,0,7,8,8,0,0,9,10,10,0,0,0,0]}
{"id":"15618","tokens":["Its","occurrence","is","considered","to","be","extremely","rare","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"8292","tokens":["Our","studies","thus","indicate","that",",","despite","the","rapidity","of","NK","cell-mediated","lysis",",","AP-1","transcription","factor","is","activated","during","the","early","stage","of","NK","cell","cytolytic","programs","and","that","engagement","of","NK","cell","inhibitory","receptors","for","MHC","class","I","molecules","impairs","the","very","early","activation","of","AP-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,10,10,10,0,0,0,0,0,0,9,0]}
{"id":"6520","tokens":["NF-kappaB","activation","is","required","for","C5a-induced","interleukin-8","gene","expression","in","mononuclear","cells","."],"ner_tags":[9,0,0,0,0,1,2,2,0,0,7,8,0]}
{"id":"8204","tokens":["We","investigated","expression","of","the","IL-2Ralpha","in","bronchoalveolar","lavage","(","BAL",")","cells","in","active","pulmonary","tuberculosis",",","and","evaluated","the","mechanism","Mycobacterium","tuberculosis","induces","in","the","IL-2Ralpha","using","the","THP-1","mononuclear","phagocyte","cell","line","."],"ner_tags":[0,0,0,0,0,9,0,7,8,8,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,5,6,6,6,6,0]}
{"id":"2700","tokens":["The","transcription","factors","Sp1","and","PU.1","prime","the","CD11b","promoter",",","but","the","nature","of","the","factors","responsible","for","its","inducible","expression","are","unknown","."],"ner_tags":[0,9,10,9,0,9,10,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8362","tokens":["We","have","reported","that","NK","cell","functions",",","such","as","proliferation",",","cell","death",",","and","killing","activity",",","are","subject","to","regulation","by","cellular","redox","status","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6811","tokens":["RESULTS",":","The","systemic","(","PBMC",")","hGR","levels","of","corticosteroid-treated","IBD","patients","were","significantly","lower","than","those","of","control","subjects","(","59.6","+\/-","57.1","dpm","mg-1","cytosol","protein","vs","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"10813","tokens":["Of","the","NF-kappaB\/Rel","family","members","tested",",","this","CD28RE\/AP-1-specific","complex","contains","predominantly","c-Rel",",","despite","the","fact","that","both","p50","and","RelA","can","efficiently","bind","to","the","CD28RE","."],"ner_tags":[0,0,9,10,10,0,0,0,9,10,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0,0,0,1,0]}
{"id":"16423","tokens":["The","number","of","estrogen","receptors","(","ER",")","in","human","peripheral","leucocytes","in","12","women","with","menopausal","type","II","diabetes","was","measured","with","radio-ligand","binding","method","."],"ner_tags":[0,0,0,9,10,0,9,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6666","tokens":["BACKGROUND",":","IL-5","controls","development","of","eosinophilia","and","has","been","shown","to","be","involved","in","the","pathogenesis","of","allergic","diseases","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14385","tokens":["UV","cross-linking","experiments","suggested","that","a","distinct","E2F","DNA-binding","protein","is","uniquely","associated","with","the","S-phase","p107","complex","and","is","not","associated","with","Rb","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,9,0]}
{"id":"12607","tokens":["Neither","of","the","two","toxins","affected","kappaB","binding","activity","induced","by","TNFalpha","in","the","same","cells","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0]}
{"id":"18383","tokens":["These","data","suggest","that","the","inhibition","of","spontaneous","lymphocyte","proliferation","by","glucocorticoids","in","vitro","is","related","to","glucocorticoid","receptor","function","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"9691","tokens":["Intragenic","deletions","of","TSG101",",","the","human","homolog","of","a","mouse","gene","(","tsg101",")","that","acts","to","suppress","malignant","cell","growth",",","were","reported","in","human","breast","tumours","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0,1,2,0,1,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"12666","tokens":["In","the","present","study","we","analyze","with","the","AR","assay","a","group","of","166","healthy","females","aged","between","8","and","94","years",",","with","no","history","of","genetic","or","neoplastic","familial","disorders","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12590","tokens":["Porcine","aortic","endothelial","cells","(","PAEC",")","were","incubated","for","1","hr","30","min","or","5","hr","with","10","%","homologous","porcine","serum","(","control",")","or","10","%","xenogeneic","human","serum","and","then","perfused","with","total","human","leukocytes","in","a","parallel","plate","flow","chamber","under","laminar","flow","(","1.5","dynes\/cm2",")","."],"ner_tags":[5,6,6,6,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12140","tokens":["We","demonstrate","here","the","interaction","of","RANK","with","tumor","necrosis","factor","receptor-associated","factors","(","TRAFs",")","1",",","2",",","3",",","5",",","and","6","both","in","vitro","and","in","cells","."],"ner_tags":[0,0,0,0,0,0,9,0,9,10,10,10,10,10,10,10,10,10,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0]}
{"id":"17531","tokens":["The","carboxy-terminal","half","of","the","HBx","protein","was","preferentially","recognized","by","antibodies","from","patients","with","chronic","hepatitis","and","contained","a","short","immunodominant","antigenic","region","with","at","least","two","major","nonoverlapping","epitopes","."],"ner_tags":[0,9,10,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,9,10,0]}
{"id":"483","tokens":["These","results","imply","that","at","least","three","signals","are","required","to","activate","the","GM-CSF","proximal","promoter",",","and","that","the","signals","impinge","on","distinct","transcription","factors","that","bind","to","the","hCLEO","and","NF-kappa","B","regions","of","the","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,9,10,0,0,0,0,1,2,2,2,2,0,0,1,0]}
{"id":"9624","tokens":["HIV","infection","is","also","associated","with","activation","of","the","hypothalamo-pituitary-adrenal","axis","function","and","increased","plasma","and","urinary","cortisol","concentrations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10621","tokens":["Lipopolysaccharide","induction","of","the","tumor","necrosis","factor-alpha","promoter","in","human","monocytic","cells","."],"ner_tags":[0,0,0,0,1,2,2,2,0,7,8,8,0]}
{"id":"12748","tokens":["The","up-regulation","of","IL-1beta","message","could","be","mediated","by","the","latent","membrane","protein-1",",","EBV","nuclear","proteins","2",",","3",",","4",",","and","6","genes","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,9,10,10,0,1,2,2,2,2,2,2,2,2,2,2,2,0]}
{"id":"9351","tokens":["The","third","member","of","the","family",",","A-myb",",","shows","the","most","restricted","pattern","of","expression",",","suggesting","a","very","specific","role","for","this","transcription","factor","."],"ner_tags":[0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8408","tokens":["The","NF-kappaB","family","of","transcription","factors","regulates","the","inducible","expression","of","a","variety","of","genes","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16082","tokens":["Lymphoid","differentiation","is","one","of","the","best","studied","examples","of","mammalian","development","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6470","tokens":["PU.1","is","a","hematopoietic-specific","Ets","family","transcription","factor","that","is","required","for","development","of","some","lymphoid","and","myeloid","lineages","."],"ner_tags":[9,0,0,9,10,10,10,10,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"13652","tokens":["Coproporphyrinogen","oxidase","(","CPO",")","catalyzes","the","sixth","step","of","the","heme","biosynthetic","pathway","."],"ner_tags":[9,10,0,9,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"7153","tokens":["Cytokine","profiles","of","peripheral","blood","mononuclear","cells","associated","with","chronic","hepatitis","B","were","analysed","by","RT-PCR","."],"ner_tags":[9,10,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"17667","tokens":["The","expression","vector","was","cotransfected","with","the","chloramphenicol","acetyl","transferase","(","CAT",")","reporter","gene","regulated","by","the","thymidine","kinase","promoter","containing","GAL4","DNA","binding","sites","into","NIH","3T3",",","293",",","K562",",","and","Jurkat","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,1,2,2,0,1,2,2,2,0,5,6,0,5,0,5,0,0,5,6,6,0]}
{"id":"5583","tokens":["Hence",",","we","have","investigated","whether","Stat","proteins","are","present","in","platelets","and",",","if","so",",","whether","they","become","tyrosine","phosphorylated","in","response","to","thrombopoietin","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"16548","tokens":["The","insertion","of","multiple","copies","of","the","binding","site","for","the","former","or","latter","factor","into","a","heterologous","promoter","reduced","the","promoter","activity","to","one-tenth","or","one-third",",","respectively","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3054","tokens":["In","vitro","mutagenesis","experiments","demonstrated","that","both","the","Ets","and","AP-1","sites","are","required","for","binding","of","the","inducible","PB1","nuclear","protein","complex","and","for","the","transcriptional","activity","of","this","element","and","the","GM-CSF","promoter","in","activated","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,1,2,0,7,8,8,0]}
{"id":"1490","tokens":["In","this","paper",",","we","report","that","cross-linking","of","CD28","(","but","not","CD2",",","CD5",",","LFA-1",",","or","CD7",")","leads","to","an","elevation","of","c-jun","mRNA",",","with","only","minimal","activation","of","c-fos","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,9,0,9,0,9,0,0,9,0,0,0,0,0,0,3,4,0,0,0,0,0,0,1,0,0]}
{"id":"17271","tokens":["This","threshold","likely","reflects","the","NF-AT","concentration-dependent","assembly","of","transcription","complexes","at","the","promoter","."],"ner_tags":[0,0,0,0,0,9,0,0,0,9,10,0,0,1,0]}
{"id":"1461","tokens":["NF","kappa","B","controls","many","immunologically","important","genes",",","so","our","studies","suggest","that","the","immune","system","may","be","sensitive","not","only","against","a","cysteine","and","glutathione","deficiency","but","also","against","an","excess","of","cysteine","."],"ner_tags":[9,10,10,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11284","tokens":["We","evaluated","the","expression","and","DNA","binding","activity","of","nuclear","factor","(","NF",")","-kappa","B","subunits","in","human","peripheral","blood","monocytes","and","in","monocyte-derived","macrophages","(","MDMs",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,7,8,8,8,0,0,7,8,0,7,0,0]}
{"id":"8402","tokens":["In","this","report",",","we","demonstrate","that","one","of","the","functions","of","CIITA","is","to","recruit","the","CREB","binding","protein","(","CBP",")","to","class","II","promoters","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,10,10,0,9,0,0,1,2,2,0]}
{"id":"15373","tokens":["Therefore",",","the","successful","generation","of","surrogate","receptors","on","non-T","cells","is","not","associated","with","more","efficient","TG","presentation","of","T","cells","."],"ner_tags":[0,0,0,0,0,0,9,10,0,7,8,0,0,0,0,0,0,9,0,0,7,8,0]}
{"id":"11526","tokens":["LR1","contains","two","polypeptides",",","of","106","kDa","and","45","kDa",",","and","here","we","report","that","the","106-kDa","component","of","LR1","is","nucleolin","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,0]}
{"id":"4776","tokens":["Identification","of","a","human","LIM-Hox","gene",",","hLH-2",",","aberrantly","expressed","in","chronic","myelogenous","leukaemia","and","located","on","9q33-34.1","."],"ner_tags":[0,0,0,1,2,2,0,1,0,0,0,0,0,0,0,0,0,0,1,0]}
{"id":"11253","tokens":["In","the","present","study","we","have","examined","the","immune","modulating","effects","of","RA","on","IL-2","mRNA",",","another","important","cytokine","for","B","cell","immunoglobulin","production",",","the","expression","of","IL-2","receptors","on","T","cells",",","and","the","RA","nuclear","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,9,0,0,0,9,0,0,0,0,0,9,10,0,7,8,0,0,0,9,10,10,0]}
{"id":"18062","tokens":["The","cellular","mechanism","governing","the","diminished","proliferative","response","of","neonatal","T","lymphocytes","to","anti-CD2","may","therefore","be","due","to","decreased","NF","kappa","B","induction",",","reduced","IL-2","mRNA","expression","and","deficient","IL-2","production","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,8,0,9,0,0,0,0,0,0,9,10,10,0,0,0,3,4,0,0,0,9,0,0]}
{"id":"6973","tokens":["All","three","steps","progressively","helpX","?","ed","to","discriminate","T-cell-specific","promoter","sequences","against","other","functional","regions","(","coding","and","intronic","sequences",")","of","the","same","genes",",","against","promoters","of","muscle-specific","genes","or","against","random","sequences","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,0,1,2,2,2,0,0,0,0,0,0,0,1,0,1,2,0,0,1,2,0]}
{"id":"11074","tokens":["EMS","analyses","utilizing","a","series","of","mutated","pp","repeat","elements","demonstrate","that","the","nucleotide","sequence","requirements","for","U1","(","U1A\/U1B",")","and","U2","formation","are","separable","from","those","required","for","C1-C3","formation","."],"ner_tags":[0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,1,0,0]}
{"id":"13199","tokens":["The","clinical","significance","of","these","findings","remains","unclear","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"17205","tokens":["DNA-protein","binding","assays","with","nuclear","extracts","from","induced","cells","demonstrate","a","high","molecular","weight","complex","on","the","enhancer","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,1,0]}
{"id":"7523","tokens":["Lung","instillation","of","TNF-alpha","in","alveolar","macrophage-depleted","rats","restored","the","NF-kappaB","activation","response","in","whole","lung","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"369","tokens":["However",",","induction","of","I","kappa","B","alpha","phosphorylation","by","both","TNF-alpha","and","the","phosphatase","inhibitors","is","associated","with","the","subsequent","degradation","of","I","kappa","B","alpha","."],"ner_tags":[0,0,0,0,9,10,10,10,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"6748","tokens":["We","conclude","that","downregulation","of","WT1","during","induced","differentiation","of","K562","cells","is","not","a","prerequisite","for","erythroid","or","megakaryocytic","differentiation","of","these","cells","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13381","tokens":["To","examine","the","possible","involvement","of","the","increased","activity","of","PI","3-kinase","in","YM268-stimulated","glucose","uptake",",","the","enzyme","activity","was","estimated","by","measuring","the","phosphatidylinositol-3",",","4",",","5-trisphosphate","(","PI-3",",","4",",","5-P3",")","concentration","in","human","monocytic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"1129","tokens":["The","9-cis","RA","was","generally","more","effective","than","all-trans","RA","in","inhibiting","HIV","production","and","in","combination","generally","more","effective","than","the","single","agents","alone","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16527","tokens":["Its","expression","remained","very","low","in","nuclei","of","HIV1-infected","macrophages","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,0]}
{"id":"14075","tokens":["The","major","goal","of","this","study","was","to","determine","whether","the","mycobacterial","cell","wall","component","mannose-capped","lipoarabinomannan","(","ManLAM",")","of","Mycobacterium","tuberculosis","(","M.","tuberculosis",")","could","activate","transcription","of","HIV-1","in","T","cells","with","the","use","of","an","in","vitro","cell","culture","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15532","tokens":["SRC-related","proto-oncogenes","and","transcription","factors","in","primary","human","T","cells",":","modulation","by","cyclosporin","A","and","FK506","."],"ner_tags":[1,2,0,9,10,0,0,7,8,8,0,0,0,0,0,0,0,0]}
{"id":"12417","tokens":["These","results","indicate","that","dexamethasone","is","able","to","abrogate","the","transcriptional","activity","of","the","human","granzyme","B","gene","promoter","by","inhibiting","the","binding","of","nuclear","factors","at","the","AP-1","and","Ikaros","sites","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,9,10,0,0,1,2,2,2,0]}
{"id":"7922","tokens":["The","biologic","effects","of","RA","are","mediated","by","two","distinct","families","of","transcriptional","factors",":","RA","receptors","(","RARs",")","and","retinoid","X","receptors","(","RXRs",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,9,0,0,9,10,10,0,9,0,0]}
{"id":"9972","tokens":["Is","celiac","disease","due","to","molecular","mimicry","between","gliadin","peptide","-HLA","class","II","molecule","-T","cell","interactions","and","those","of","some","unidentified","superantigen","?"],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,10,0]}
{"id":"719","tokens":["Identification","of","a","major","positive","regulatory","element","located","5","'","to","the","human","zeta-globin","gene","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,1,2,2,0]}
{"id":"9868","tokens":["Experiments","with","T","cell","hybridomas","confirmed","these","findings","and","suggested","that","a","unique","transcription","factor","may","be","essential","for","human","IL-5","gene","transcription","."],"ner_tags":[0,0,5,6,6,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,9,0,0,0]}
{"id":"5095","tokens":["Thus",",","the","RAR-RXR","response","pathway","can","signal","growth","inhibition","of","normal","bone","marrow","myeloid","and","erythroid","progenitor","cells","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,7,8,8,8,8,8,8,8,0]}
{"id":"14458","tokens":["These","effects","were","characterized","by","a","marked","reduction","in","CD11b","integrin","expression","on","the","surface","of","treated","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,9,0,0,0,0,0,5,6,0]}
{"id":"9835","tokens":["Further",",","monocytes","from","patients","demonstrate","an","augmented","susceptibility","to","a","productive","infection","with","HIV-1","in","vitro","."],"ner_tags":[0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8015","tokens":["Differential","regulation","of","4E-BP1","and","4E-BP2",",","two","repressors","of","translation","initiation",",","during","human","myeloid","cell","differentiation","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,0,0,0,7,8,8,0,0]}
{"id":"4423","tokens":["The","transcriptional","activity","of","the","NFAT","binding","site","is","mediated","by","a","complex","comprising","a","member","of","the","NFAT","group","and","AP-1","family","proteins","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,10,0]}
{"id":"16962","tokens":["We","have","studied","the","mode","of","inheritance","in","eight","families","with","a","total","of","nine","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9891","tokens":["The","POU","transcription","factors","Oct-1","and","Oct-2","regulate","the","activity","of","octamer-dependent","promoters",",","including","those","that","direct","transcription","from","rearranged","immunoglobulin","genes","."],"ner_tags":[0,9,10,10,9,0,9,0,0,0,0,1,2,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"2819","tokens":["Such","a","diverse","pathway","of","monocyte","differentiation","may","constitute","one","of","the","basic","mechanisms","of","immune","regulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4568","tokens":["Furthermore",",","JAK2","associated","with","the","IL-4R","p140","before","and","after","stimulation","with","IL-13","."],"ner_tags":[0,0,9,0,0,0,9,10,0,0,0,0,0,9,0]}
{"id":"12953","tokens":["BMT","inhibited","the","replication","of","HIV-1","in","both","laboratory","and","primary","isolates","in","vitro","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10394","tokens":["The","regulation","of","NF-kappa","B","activation","following","the","triggering","of","HLA-DR","antigens","by","mAb","L243","has","been","studied","at","various","times","in","Raji","cells","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,5,6,0]}
{"id":"6182","tokens":["The","inhibitory","agent","has","several","features","characteristic","of","a","ganglioside",",","including","sensitivity","to","neuraminidase","but","not","protease","treatment",";","hydrophobicity",";","and","molecular","weight","less","than","3","kDa","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8356","tokens":["RANTES","is","expressed","late","(","3-5","days",")","after","activation","in","T","lymphocytes","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"11582","tokens":["In","contrast",",","neither","ascorbate","nor","AZT","affected","NF-kappa","B","activity","under","all","three","induction","conditions","in","the","ACH-2","cell","line","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"17637","tokens":["No","receptor","abnormalities","were","detected","in","the","MDD","group",";","thus","any","cellular","defect","leading","to","a","lack","of","responsiveness","to","GC","in","the","MDD","patients",",","if","present",",","probably","lies","beyond","the","initial","receptor","binding","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6031","tokens":["An","insertion","mutation","was","constructed","in","the","rpoS","gene","on","the","chromosome","of","L.","pneumophila",",","and","the","ability","of","this","mutant","strain","to","survive","various","stress","conditions","was","assayed","and","compared","with","results","for","the","wild-type","strain","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5636","tokens":["We","further","explored","the","effect","of","dopamine","in","the","presence","of","phorbol","esters","or","tumor","necrosis","factor-alpha","(","TNF-alpha",")","known","to","activate","NF-kappaB","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,9,0]}
{"id":"17178","tokens":["The","protein","synthesis","inhibitor","cycloheximide","did","not","block","the","induction","of","any","of","these","genes",",","and","in","fact",",","super-induced","the","expression","of","c-jun","and","hck","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0]}
{"id":"8792","tokens":["The","Wilms","'","tumor","suppressor","gene","(","WT1",")","was","previously","identified","as","being","imprinted",",","with","frequent","maternal","expression","in","human","placentae","and","fetal","brains","."],"ner_tags":[0,1,2,2,2,2,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11417","tokens":["Activation","of","the","NF-kappaB","pathway","by","inflammatory","stimuli","in","human","neutrophils","."],"ner_tags":[0,0,0,9,0,0,0,0,0,7,8,0]}
{"id":"6325","tokens":["Distinctive","expression","pattern","of","the","BCL-6","protein","in","nodular","lymphocyte","predominance","Hodgkin","'s","disease","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"3927","tokens":["Immunodepletion","studies","show","that","PTF","beta","is","required","for","transcription","of","both","classes","of","snRNA","genes","in","vitro","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,1,2,0,0,0]}
{"id":"16635","tokens":["Furthermore",",","JunD","is","shown","to","activate","transcription","of","genes","linked","to","both","cAMP","and","phorbol","ester","response","elements","in","a","protein","kinase","A","-dependent","fashion",",","further","blurring","the","distinction","between","these","response","elements","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"14207","tokens":["Taken","together",",","our","findings","indicate","that","IL-2","induces","gene","expression","of","M-CSF","in","human","blood-derived","Mo","and","provide","evidence","for","involvement","of","NF-kappa","B","in","transcriptional","regulation","of","this","gene","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,9,0,7,8,8,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"11871","tokens":["During","inflammatory","reactions",",","many","oxidative","species","are","produced",",","one","of","which","is","hypochlorous","acid","(","HOCl",")",",","which","is","responsible","for","the","microbicidal","effects","of","activated","human","polymorphonuclear","leukocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"9752","tokens":["Transcription","factor","NF-kappa","B","must","be","released","from","cytoplasmic","inhibitory","molecules","(","I","kappa","Bs",")","in","order","to","move","to","the","nucleus","and","to","activate","its","target","genes","."],"ner_tags":[9,10,9,10,0,0,0,0,9,10,10,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"2029","tokens":["Normal","T","lymphocytes","whose","surface","expression","of","CD3","was","depleted","showed","impaired","UV-induced","tyrosine","phosphorylation","and","Ca2+","signals","."],"ner_tags":[0,7,8,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13487","tokens":["In","contrast",",","IL-13","levels","were","not","elevated","."],"ner_tags":[0,0,0,9,0,0,0,0,0]}
{"id":"12127","tokens":["The","mechanism","underlying","this","association","is","so","far","not","explored","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10673","tokens":["Most","interestingly",",","the","N-terminal","SH2","domain","had","an","inhibitory","effect",",","whereas","a","mutant","p85","containing","only","the","two","SH2","domains","enhanced","basal","NFAT","activity","in","a","Ras","-dependent","manner","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,0,0,9,0,0,0,9,0,0,0]}
{"id":"12429","tokens":["NGAL","levels","varied","in","these","tumors","from","undetectable","to","exceeding","those","in","normal","breast","parenchyma","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15511","tokens":["In","contrast",",","the","class","II-positive","nonlymphoid","glioblastoma","cell","line","does","not","exhibit","interactions","at","the","octamer","site","despite","the","presence","of","the","ubiquitous","OTF-1","factor","and","an","open","binding","site","."],"ner_tags":[0,0,0,0,5,6,6,6,6,6,0,0,0,0,0,0,1,2,0,0,0,0,0,9,10,10,0,0,1,2,2,0]}
{"id":"14139","tokens":["Sequence","analysis","of","nine","different","2.3-kb","cDNA","clones","obtained","from","NK-derived","polyA+","RNA","confirmed","that","they","corresponded","to","an","unrearranged","TcR","delta","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"17131","tokens":["This","sequence","motif","is","a","binding","site","for","nuclear","proteins",",","the","so-called","octamer","transcription","factors","(","Oct","or","OTF","factors",")","."],"ner_tags":[0,1,2,0,0,0,0,0,9,10,0,0,0,9,10,10,0,9,0,9,10,0,0]}
{"id":"14635","tokens":["Members","of","this","group","have","three","tetraproline","repeats","."],"ner_tags":[0,0,0,0,0,9,10,10,0]}
{"id":"7475","tokens":["Other","steroid","receptor","drugs","such","as","Raloxifene",",","RU486",",","or","the","ICI","182",",","780","in","PMA-differentiated","cells","displayed","agonist","activity","by","preventing","TNF-alpha","-induced","apoptosis","as","efficiently","as","the","hormones","alone",",","providing","further","evidence","to","the","notion","that","steroid","receptor","drugs","may","manifest","agonist","or","antagonist","activities","depending","on","the","cellular","context","in","which","they","are","studied","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6902","tokens":["Thus",",","cosignaling","via","the","LT-beta","and","TNF-alpha","receptors","is","probably","involved","in","the","modulation","of","HIV-1","replication","and","the","subsequent","determination","of","HIV-1","viral","burden","in","monocytes","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"10123","tokens":["Among","the","regulatory","promoter","elements","potentially","regulating","eotaxin","gene","expression","and\/or","mediating","the","effects","of","anti-inflammatory","drugs","we","identified","consensus","sequences","known","to","interact","with","nuclear","factors","like","NF-IL6",",","AP-1",",","a","NF-kappa-B","like","consensus","sequence","and","gamma-interferon-","as","well","as","glucocorticoid","response","elements","."],"ner_tags":[0,0,1,2,2,0,0,1,2,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,9,10,0,9,0,9,0,0,1,2,2,2,0,1,2,2,2,2,2,2,0]}
{"id":"18203","tokens":["One","such","cofactor",",","BOB.1\/OBF.1",",","was","recently","isolated","from","human","B","cells","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,7,8,8,0]}
{"id":"17220","tokens":["The","expression","of","the","gene","encoding","the","granulocyte-macrophage","colony-stimulating","factor","(","GM-CSF",")","is","induced","upon","activation","of","T","cells","with","phytohemagglutinin","and","active","phorbolester","and","upon","expression","of","tax1",",","a","transactivating","protein","of","the","human","T-cell","leukemia","virus","type","I","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,7,8,0,9,0,0,0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"2383","tokens":["Furthermore",",","cyclosporin","A",",","but","not","rapamycin",",","blocked","the","synergistic","induction","of","IL-8","expression","achieved","with","anti-CD3","and","anti-","CD28","costimulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,0,0,9,0,0]}
{"id":"1349","tokens":["Missense","mutation","in","exon","7","of","the","common","gamma","chain","gene","causes","a","moderate","form","of","X-linked","combined","immunodeficiency","."],"ner_tags":[0,0,0,1,2,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0]}
{"id":"311","tokens":["A","possible","signaling","role","for","the","Syk","tyrosine","kinase","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0]}
{"id":"2780","tokens":["Human","cDNAs","encoding","subunits","of","these","factors","have","been","cloned","and","sequenced","."],"ner_tags":[1,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9430","tokens":["Epstein-Barr","virus","EBNA3C","represses","Cp",",","the","major","promoter","for","EBNA","expression",",","but","has","no","effect","on","the","promoter","of","the","cell","gene","CD21","."],"ner_tags":[0,0,9,0,1,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"14627","tokens":["Is","GATA-1","necessary","for","globin","gene","switching","?","GATA-1","may","be","modified","differently","during","development","so","that","the","locus","control","region","can","interact","with","different","globin","promoters","."],"ner_tags":[0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"17436","tokens":["Detection","in","non-erythroid","cells","of","a","factor","with","the","binding","characteristics","of","the","erythroid","cell","transcription","factor","EF1","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,9,10,10,10,9,0]}
{"id":"17556","tokens":["The","inducible","C1","protein","was","partially","purified","by","three","chromatographic","steps","and","characterized","by","u.v.","cross-linking","as","a","47","kDa","protein","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"7218","tokens":["Although","many","functions","of","human","alveolar","macrophages","are","altered","compared","with","their","precursor","cell",",","the","blood","monocyte","(","monocyte",")",",","the","reason","(","s",")","for","these","functional","changes","have","not","been","determined","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,0,0,7,8,0,0,7,8,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15273","tokens":["The","addition","of","antisense","oligonucleotides","to","c-fos","significantly","inhibited","IL","6","-induced","IgM","production","by","SKW","6.4","cells","(","p","less","than","0.001",")",",","whereas","control","oligonucleotides","had","no","inhibitory","effect","."],"ner_tags":[0,0,0,0,0,0,1,0,0,9,10,0,9,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2194","tokens":["Eleven","of","the","17","patients","had","abnormal","karyotypes","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"9587","tokens":["Although","the","growth","rate","was","normal",",","the","XP-B","and","XP-D","cells","contained","reduced","amounts","of","TFIIH","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,9,0]}
{"id":"12064","tokens":["This","resistance","to","apoptosis","is","reversed","by","anti-TIMP-1","antibodies",",","demonstrating","that","secreted","TIMP-1","is","active","in","blocking","apoptosis","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"11317","tokens":["On","the","other","hand",",","AML1b","conferred","a","similar","differentiation-inducing","capacity","upon","K562","cells","transfected","with","vector","alone","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,5,6,0,0,0,0,0]}
{"id":"4703","tokens":["In","this","study",",","we","examined","the","expression","of","two","T-cell-specific","transcription","factors","(","TCF-1","and","GATA-3",")","and","one","B-cell-specific","transcription","factor","(","BSAP",")","in","cultured","H-RS","cells","by","using","a","gel","mobility","shift","assay","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,9,0,0,0,9,10,10,0,9,0,0,5,6,6,0,0,0,0,0,0,0,0]}
{"id":"1063","tokens":["A","predominance","of","p50","NF-kappa","B","moieties","and","possibly","p50","homodimers","or","closely","related","species",",","rather","than","the","p50-p56","heterodimer","of","NF-kappa","B","that","is","the","predominant","NF-kappa","B","species","in","most","T","lymphocytic","and","monocytic","cells",",","is","demonstrated","in","the","nuclei","of","U1","cells","."],"ner_tags":[0,0,0,9,10,10,10,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0,9,10,0,0,0,0,9,10,0,0,0,7,8,8,8,8,0,0,0,0,0,0,0,5,6,0]}
{"id":"10007","tokens":["Cloning","of","the","cDNA","encoding","human","SR-BP","shows","an","open","reading","frame","for","a","223-amino","acid","protein",",","which","is","homologous","to","the","recently","cloned","sigma","1","receptor","."],"ner_tags":[0,0,0,1,0,9,10,0,0,1,2,2,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"14186","tokens":["4","patients","were","receiving","dopamine",",","which","did","not","affect","the","GR","count","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"8609","tokens":["Deltorphin","also","increased","accumulation","of","AP-1","transcription","factor","complexes",",","suggesting","that","DOR1","augments","IL-2","secretion","by","increasing","the","AP-1","component","of","the","NF-AT\/AP-1","transcription","factor","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,0,0,9,0,9,0,0,0,0,9,10,0,0,9,10,10,0]}
{"id":"4334","tokens":["The","GM-CSF","locus","may","represent","one","of","several","target","genes","that","are","dysregulated","in","acute","myeloid","leukemia","."],"ner_tags":[0,1,2,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"17147","tokens":["[","Endocrine","status","changes","in","children","with","bronchial","asthma","]"],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"2305","tokens":["Macrophages","and","T","and","B","lymphocytes","infiltrated","the","tumor","in","moderate","numbers","with","occasional","lymphoid","aggregate","formation","."],"ner_tags":[7,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12737","tokens":["Apoptotic","cells","were","rarely","found","in","control","and","subject","endometria","."],"ner_tags":[7,8,0,0,0,0,0,0,0,0,0]}
{"id":"7016","tokens":["PML","mRNA","and","protein",",","while","barely","detectable","in","quiescent","HPCs",",","are","consistently","induced","by","growth","factor","stimulation","through","the","erythroid","or","granulocytic","lineage","."],"ner_tags":[3,4,0,9,0,0,0,0,0,0,7,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"5330","tokens":["In","contrast",",","anti-CD3","and","anti-CD28","stimulated","Rel-\/-","T","cells",",","which","fail","to","proliferate",",","make","little","or","no","detectable","cytokines","."],"ner_tags":[0,0,0,9,0,9,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"15712","tokens":["We","also","present","evidence","that","IL-6","kappa","B","binding","factor","II","functions","as","a","repressor","specific","for","IL-6","kappa","B-related","kappa","B","motifs","in","lymphoid","cells","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,0,1,2,2,2,2,2,0,7,8,0]}
{"id":"9389","tokens":["In","contrast",",","the","binding","activities","of","NF1","and","Sp1","were","not","affected","by","ER","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,9,0]}
{"id":"15447","tokens":["Nuclear","transcription","studies","in","vitro","showed","that","LTB4","increased","the","transcription","of","the","c-fos","gene","7-fold","and","the","c-jun","gene","1.4-fold","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,0,0]}
{"id":"7894","tokens":["Our","results","suggest","that","the","JNK","pathway","may","regulate","NF-kappa","B","-mediated","gene","transcription","through","its","phosphorylation","and","activation","of","c-Jun","."],"ner_tags":[0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"13921","tokens":["MyD88",",","originally","isolated","as","a","myeloid","differentiation","primary","response","gene",",","is","shown","to","act","as","an","adaptor","in","interleukin-1","(","IL-1",")","signaling","by","interacting","with","both","the","IL-1","receptor","complex","and","IL-1","receptor-associated","kinase","(","IRAK",")","."],"ner_tags":[9,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,9,10,10,0,9,10,10,0,9,0,0]}
{"id":"14724","tokens":["In","contrast",",","protease","treatment","and","analysis","of","SJO","extracts","showed","no","detectable","levels","of","the","band","1pk","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,5,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8186","tokens":["In","the","present","study",",","we","utilized","RXR","-and","RAR","-specific","agonists","and","antagonists","to","determine","how","RA","overcomes","the","dominant-negative","activity","of","the","truncated","RARalpha","in","these","different","myeloid","developmental","stages","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"13345","tokens":["In","this","study","we","report","on","the","establishment","and","characterization","of","two","novel","lymphoma","cell","lines","(","CRO-AP\/3","and","CRO-AP\/5",")","which","carry","infection","by","human","herpesvirus","type-8","(","HHV-8",")","and","have","derived","from","AIDS-related","primary","effusion","lymphoma","(","PEL",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,5,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,0]}
{"id":"6547","tokens":["These","results","suggest","that","the","activation","signals","in","human","B","cells","and","monocytes","differ","following","CD40","stimulation","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,8,0,7,0,0,9,0,0]}
{"id":"2396","tokens":["We","determined","the","effects","of","glucocorticoids","on","lymphocyte","proliferation","and","cytokine","release","."],"ner_tags":[0,0,0,0,0,0,0,7,0,0,9,0,0]}
{"id":"2183","tokens":["The","immunosuppressant","drug","cyclosporin","A","blocks","a","calcium-dependent","signal","from","the","T-cell","receptor","(","TCR",")","that","normally","leads","to","T-cell","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0]}
{"id":"15409","tokens":["The","results","demonstrate","that","okadaic","acid","treatment","is","associated","with","induction","of","a","differentiated","monocyte","phenotype","characterized","by",":","(","a",")","growth","arrest",";","(","b",")","increases","in","Mac-1","cell","surface","antigen","expression",";","(","c",")","down-regulation","of","c-myc","transcripts",";","and","(","d",")","induction","of","tumor","necrosis","factor","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,1,2,2,2,0,0]}
{"id":"16948","tokens":["c-myc","RNA",",","which","is","constitutively","expressed","in","RWLeu-4","cells",",","increased","after","0.5","h","of","treatment","with","50","nM","VD3","and","then","rapidly","decreased","to","barely","detectable","levels","after","4","h","of","treatment","."],"ner_tags":[3,4,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14370","tokens":["We","have","previously","shown","that","nuclear","extracts","from","activated","T","cells","form","two","inducible","NF-AT","complexes","with","an","oligonucleotide","corresponding","to","the","distal","NF-AT","site","of","the","murine","IL-2","promoter",",","although","hypotonic","extracts","of","unstimulated","T","cells","form","a","single","complex","containing","NF-ATp","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,8,0,0,0,9,10,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0,0,0,0,0,0,7,8,0,0,0,0,0,9,0]}
{"id":"7758","tokens":["Specific","inhibitors","of","p38alpha","MAPk","blocked","LPS-induced","adhesion",",","nuclear","factor-kappa","B","(","NF-kappaB",")","activation",",","and","synthesis","of","tumor","necrosis","factor-alpha","(","TNF-alpha",")","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"4133","tokens":["The","core","GGAAs","of","the","muA","and","muB","sites","are","separated","by","30","nucleotides",",","suggesting","that","ETS","proteins","bind","to","these","sites","from","these","same","side","of","the","DNA","helix","."],"ner_tags":[0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6743","tokens":["Overexpression","of","WT1","in","some","myeloid","cell","lines","confers","resistance","to","differentiation","induction","."],"ner_tags":[0,0,1,0,0,5,6,6,0,0,0,0,0,0]}
{"id":"8462","tokens":["Gliotoxin","also","augmented","dramatically","the","early","(","2-6","h",")","pro-apoptotic","effects","of","tumor","necrosis","factor-alpha","(","TNF-alpha",")","in","neutrophils","and","unmasked","the","ability","of","TNF-alpha","to","induce","eosinophil","apoptosis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,7,0,0,0,0,0,9,0,0,7,0,0]}
{"id":"2650","tokens":["Hypoxia","causes","the","activation","of","nuclear","factor","kappa","B","through","the","phosphorylation","of","I","kappa","B","alpha","on","tyrosine","residues","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"18071","tokens":["These","data","indicate","that","TCL1","is","activated","in","preleukemic","clonal","cells","as","a","consequence","of","chromosome","translocation","involving","sequences","from","the","TCR","locus","at","14q11","."],"ner_tags":[0,0,0,0,1,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,1,2,0,1,0]}
{"id":"7938","tokens":["Previous","studies","have","implicated","a","role","for","intracellular","thiols","in","the","activation","of","nuclear","factor-kappaB","and","transcriptional","regulation","of","endothelial","cell","adhesion","molecules","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,9,10,10,10,0]}
{"id":"10907","tokens":["Cytokines",":","shared","receptors",",","distinct","functions","."],"ner_tags":[9,0,0,9,0,0,0,0]}
{"id":"14864","tokens":["Jurkat","T","cells","stably","expressing","tax","contained","elevated","levels","of","NF-kappa","B","that","directly","bound","to","the","LT-kappa","B","site","."],"ner_tags":[5,6,6,0,0,9,0,0,0,0,9,10,0,0,0,0,0,1,2,2,0]}
{"id":"15797","tokens":["Analysis","of","IL-2R","alpha","expression","by","transient","transfection","of","IL-2R","alpha","promoter","constructs","into","the","HB24","transfectants","revealed","constitutive","expression","(","about","60","%","of","phytohemagglutinin-","and","phorbol","ester-activated","Jurkat","cells",")","that","was","dependent","on","the","kappa","B","site","in","the","IL-2R","alpha","promoter","."],"ner_tags":[0,0,9,10,0,0,0,0,0,1,2,2,2,0,0,5,6,0,0,0,0,0,0,0,0,5,6,6,6,6,6,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0]}
{"id":"12218","tokens":["Only","a","few","cells","showed","viral","capsid","antigen","(","VCA",")","."],"ner_tags":[0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"5960","tokens":["T-PLL","is","also","seen","in","non-A-T","individuals","where","expression","of","either","TCL1","(","at","14q32",")","or","the","c6.1B\/MTCP1","A1","transcript","(","at-Xq28",")","has","been","demonstrated","in","just","a","few","instances","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,1,0,0,0,9,10,10,0,1,0,0,0,0,0,0,0,0,0,0]}
{"id":"8185","tokens":["Nevertheless",",","relatively","high",",","pharmacological","concentrations","of","RA","(","1","to","10","&","mgr",";","M",")","overcome","these","differentiation","blocks","and","induce","terminal","granulocytic","differentiation","of","the","MPRO","promyelocytes","while","potentiating","interleukin-3","(","IL-3",")","-induced","commitment","of","EML","cells","to","the","granulocyte\/monocyte","lineage","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,9,0,9,0,0,0,0,7,8,0,0,0,0,0]}
{"id":"8842","tokens":["Interleukin","16","(","IL-16",")","is","a","chemotactic","cytokine","that","binds","to","the","CD4","receptor","and","affects","the","activation","of","T","cells","and","replication","of","HIV","."],"ner_tags":[9,10,0,9,0,0,0,9,10,0,0,0,0,9,10,0,0,0,0,0,7,8,0,0,0,0,0]}
{"id":"9128","tokens":["Oleate","also","produced","a","quantitatively","similar","reduction","of","VCAM-1","mRNA","levels","on","Northern","blot","analysis","and","inhibited","nuclear","factor-kappaB","activation","on","electrophoretic","mobility","shift","assays","."],"ner_tags":[0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"15734","tokens":["The","enhanced","initiation","of","transcription","of","the","TF","gene","appears","to","require","engagement","of","a","56","bp","LPS","Response","Element",",","an","enhancer","that","is","engaged","by","both","AP-1","type","heterodimeric","complexes","as","well","as","NF","kappa","B","like","heterodimeric","complexes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,9,10,10,10,10,10,0]}
{"id":"16485","tokens":["cDNA","clones","for","the","human","erythroid","ALAS","isozyme","were","isolated","from","a","fetal","liver","library","."],"ner_tags":[1,2,0,0,9,10,10,10,0,0,0,0,0,0,0,0]}
{"id":"14550","tokens":["In","contrast","to","the","decrease","in","GR","mRNA","seen","in","IM-9","cells","after","treatment","with","1","microM","dexamethasone","for","16-18","h",",","treatment","of","6TG1.1","cells","resulted","in","an","8-fold","increase","in","GR","mRNA",",","as","determined","by","Northern","blot","and","RNase","protection","analysis",",","with","a","corresponding","3-","to","4-fold","increase","in","GR","protein","."],"ner_tags":[0,0,0,0,0,0,3,4,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"11166","tokens":["Immunoblot","and","flow","cytometry","analysis","revealed","a","limited","proteolysis","of","the","carboxyl","terminus","of","the","alphaIIb","subunit","heavy","chain","(","alphaIIbH",")",",","as","judged","by","the","disappearance","of","the","epitope","for","the","monoclonal","antibody","PMI-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"11683","tokens":["The","treatment","with","anti-V3","loop","monoclonal","antibody","(","902","antibody",")","completely","abolished","the","suppressive","effect","of","V3-BH10","."],"ner_tags":[0,0,0,9,10,10,10,0,9,10,0,0,0,0,0,0,0,9,0]}
{"id":"9042","tokens":["CONCLUSIONS",":","The","diagnosis","of","GCT","should","be","based","primarily","on","the","typical","morphology","revealed","by","conventional","stains",",","but","additional","immunohistochemical","staining","with","a","small","panel","of","selected","antibodies","(","for","example",",","against","keratin",",","vimentin",",","and","inhibin","A",")","may","be","helpful","in","a","few","cases","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"5843","tokens":["Recent","data","show","that","TCR\/CD3","stimulation","induces","activation","of","Stat5","in","murine","T","cells","."],"ner_tags":[0,0,0,0,9,0,0,0,0,9,0,7,8,8,0]}
{"id":"13610","tokens":["To","elucidate","the","role","of","retinoic","acid","(","RA",")","in","anti-CD40","+","interleukin-4","(","IL-4",")","-mediated","B-cell","activation",",","the","effect","of","10","(","-12",")","to","10","(","-6",")","mol\/L","RA","was","studied","in","anti-CD40","(","1","microgram\/mL",")","+","IL-4","(","5","ng\/mL",")","-mediated","proliferation","and","Ig","synthesis","by","human","peripheral","blood","mononuclear","cells","(","PBMC",")","and","B","cells","in","healthy","donors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,0,7,0,0,7,8,0,0,0,0]}
{"id":"13160","tokens":["The","other","two","contained","mutations","in","regions","that","do","not","have","homology","to","described","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6270","tokens":["Using","a","combination","of","bacterial","motility","assays","in","platelet","extracts","with","Escherichia","coli","expressing","the","Shigella","IcsA","protein","and","in","vitro","analysis","of","reconstituted","systems","from","purified","proteins",",","we","show","here","that","the","bacterial","protein","IcsA","binds","N-WASP","and","activates","it","in","a","Cdc42","-like","fashion","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,9,0,0,0]}
{"id":"15111","tokens":["Initial","and","post-dexamethasone","in","vitro","fibroblast","binding","to","glucocorticoid","was","not","different","between","major","depressive","disorder","and","non-depressed","control","subjects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4845","tokens":["The","NFAT","protein","migrated","more","slowly","in","a","sodium","dodecyl","sulfate-polyacrylamide","gel","than","the","CMAT","protein","did","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"13063","tokens":["Many","of","these","genes","have","not","previously","been","shown","to","funcion","in","the","stimulated","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"5146","tokens":["These","findings","with","IkappaBbeta","provide","a","potential","mechanism","for","the","constitutive","activation","of","NF-kappaB","in","Tax-expressing","cells","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,5,6,0]}
{"id":"597","tokens":["This","study","illustrates","the","almost","complete","tolerance","of","mice","for","human","TCF-1","and","demonstrates","that","this","tolerance","is","readily","broken","by","gene","knock-out","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14991","tokens":["To","examine","the","role","of","mineralocorticoids","in","the","pathophysiology","of","PIH",",","we","studied","plasma","aldosterone","and","18-hydroxy-corticosterone","(","18-OH-B",")","levels","in","25","women","with","PIH","and","in","25","healthy","pregnant","women","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"886","tokens":["A","similar","potentiation","of","TNF","effects","was","observed","in","Jurkat","T","cells","and","HeLa","cells","treated","with","soluble","Tat","protein","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,5,6,0,0,0,9,10,0]}
{"id":"13574","tokens":["Induction","of","T","cell","anergy","by","high","concentrations","of","immunodominant","native","peptide","is","accompanied","by","IL-10","production","and","a","block","in","JNK","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,0,0]}
{"id":"4023","tokens":["The","common","target","of","CsA","and","FK506","is","calcineurin",",","a","Ca2+\/calmodulin-regulated",",","serine\/threonine-specific","protein","phosphatase","that","regulates","the","nuclear","import","of","a","transcription","factor",",","NF-AT",",","required","for","expression","of","T","cell","activation","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,9,10,10,10,10,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,1,2,2,2,0]}
{"id":"1806","tokens":["Expression","of","a","constitutively","active","calcineurin","(","CN",")",",","a","Ca2+\/calmodulin-dependent","protein","phosphatase",",","potentiated","by","two","fold","the","transcriptional","activation","by","NF-kappa","B","\/AP-1","."],"ner_tags":[0,0,0,0,0,9,0,9,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,9,10,9,0]}
{"id":"10307","tokens":["This","review","focuses","on","the","molecular","actions","of","prolactin","in","the","immune","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6989","tokens":["The","c-Myc","oncoprotein","is","important","in","control","of","cellular","proliferation","and","differentiation",",","while","Yin-Yang","1","(","YY1",")","has","been","shown","to","control","the","expression","of","a","number","of","cellular","and","viral","genes","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"16560","tokens":["Levels","of","c-fos","and","c-jun","transcripts","remained","elevated","during","periods","of","PKC","activation","and","also","returned","to","levels","observed","in","control","cells","by","30-36","days",",","when","the","cells","entered","retrodifferentiation","."],"ner_tags":[0,0,3,4,4,4,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2042","tokens":["Exposure","of","monocytic","cells","to","bacterial","lipopolysaccharide","(","LPS",")","activates","the","NF-kappa","B\/Rel","family","of","proteins","and","leads","to","the","rapid","induction","of","inflammatory","gene","products",",","including","tissue","factor","(","TF",")","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,10,0,9,0,0]}
{"id":"16186","tokens":["Glucocorticoid","pharmacokinetics",",","glucocorticoid","receptor","characteristics",",","and","inhibition","of","peripheral","blood","T","cell","proliferation","by","glucocorticoids","in","vitro","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0]}
{"id":"8978","tokens":["The","testosterone-BSA-induced","Ca2+","import","is","not","affected","by","cyproterone",",","a","blocker","of","the","AR","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"17832","tokens":["Activation","through","the","Ca2+\/","calcineurin","pathway","is","essential","to","the","transcription","of","many","cytokine","genes","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"18243","tokens":["GP","Ib","alpha","promoter","activity","was","evaluated","by","transfection","of","human","erythroleukemia","cells","with","reporter","plasmids","coding","for","the","enzyme",",","luciferase","."],"ner_tags":[1,2,2,2,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,9,0,9,0]}
{"id":"17442","tokens":["Rex","is","a","phosphoprotein","found","in","the","cell","nucleolus",",","whose","function","may","be","regulated","by","its","localization","and","phosphorylation","."],"ner_tags":[9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1761","tokens":["Mechanism","of","antiandrogen","action",":","conformational","changes","of","the","receptor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10541","tokens":["Activation","and","regulation","of","NF-kappa","B","are","tightly","controlled","by","a","group","of","inhibitory","proteins","(","I","kappa","B",")","that","sequester","NF-kappa","B","in","the","cytoplasm","of","immune\/inflammatory","effector","cells","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,9,10,0,9,10,10,0,0,0,9,10,0,0,0,0,7,8,8,0]}
{"id":"1133","tokens":["Human","RAR","alpha","expression","was","unchanged","in","H9","and","CEM","cells",",","and","elevated","in","U937","cells",",","after","PMA","stimulation","."],"ner_tags":[0,0,0,0,0,0,0,5,0,5,6,0,0,0,0,5,6,0,0,0,0,0]}
{"id":"11399","tokens":["One","hour","pulse-treatment","with","3","microM","etoposide","caused","topoisomerase","associated",",","primary","DNA","breakage",",","which","was","rapidly","followed","by","apoptosis","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10463","tokens":["These","studies","also","confirm","that","AAV","is","an","efficient","delivery","vehicle","for","cytokines","to","leukemic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"15975","tokens":["In","T","cells",",","HIV","transcription","is","poorly","detected","in","vivo","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0]}
{"id":"13133","tokens":["The","YJ","cells","could","be","induced","towards","monocytic","differentiation","by","stimulation","with","phorbol","12-myristate","13-acetate","(","PMA",")","."],"ner_tags":[0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7145","tokens":["IL-2","secretion","was","paralleled","by","increased","expression","of","IL-2","mRNA",",","resulting","from","enhanced","IL-2","mRNA","stability","."],"ner_tags":[9,0,0,0,0,0,0,0,3,4,0,0,0,0,3,4,0,0]}
{"id":"18393","tokens":["As","one","test","of","this","hypothesis",",","we","compared","the","abilities","of","E1A","-and","E7","-expressing","human","fibroblastic","or","keratinocyte-derived","human","cells","to","be","selectively","killed","by","either","unstimulated","or","interferon","(","IFN",")","-activated","NK","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,5,6,6,6,6,6,0,0,0,0,0,0,7,0,5,6,6,6,6,6,6,0]}
{"id":"15421","tokens":["Both","c-Fos","and","c-Jun","protein","levels","were","increased","after","Con","A","and","PHA","stimulation","."],"ner_tags":[0,9,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6078","tokens":["In","addition",",","H-7","(","10","microM",")",",","a","specific","inhibitor","of","serine\/threonine","kinases",",","significantly","blocked","IL-10","mediated","c-fos","expression","(","p","<","0.05",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,0,1,0,0,0,0,0,0,0]}
{"id":"9386","tokens":["The","estrogen","receptor","(","ER",")","repressed","erythroid","differentiation","and","erythroid-specific","gene","expression","."],"ner_tags":[0,9,10,0,9,0,0,0,0,0,1,2,0,0]}
{"id":"9916","tokens":["Transcriptional","up-regulation","of","the","c-sis\/platelet-derived","growth","factor-B","(","PDGF-B",")","proto-oncogene","by","the","Tax","protein","of","human","T-cell","leukemia","virus","type","1","has","been","implicated","as","one","possible","mechanism","of","cellular","transformation","by","human","T-cell","leukemia","virus","type","1","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,2,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6987","tokens":["USF\/c-Myc","enhances",",","while","Yin-Yang","1","suppresses",",","the","promoter","activity","of","CXCR4",",","a","coreceptor","for","HIV-1","entry","."],"ner_tags":[9,0,0,0,9,10,0,0,0,0,0,0,9,0,0,9,0,0,0,0]}
{"id":"11328","tokens":["In","addition",",","both","inducible","nitric","oxide","synthase","-mRNA","level","and","NO","generation","in","mouse","peritoneal","macrophages","were","suppressed","by","10","(","-5",")","M","Azeptin","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"10085","tokens":["After","stimulation",",","neutrophils","separated","from","a","healthy","human","volunteer","were","added","with","or","without","anti-CD18","antibody","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"13581","tokens":["Both","T","cell","lines","could","be","anergized","by","the","autopresentation","of","native","peptide","since","anergy","was","induced","in","cultures","lacking","fresh","antigen-presenting","cells","."],"ner_tags":[0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"4532","tokens":["Cooperation","between","core","binding","factor","and","adjacent","promoter","elements","contributes","to","the","tissue-specific","expression","of","interleukin-3","."],"ner_tags":[0,0,9,10,10,0,1,2,2,0,0,0,0,0,0,9,0]}
{"id":"7676","tokens":["A","cdk2","inhibitor",",","Olomoucine",",","as","well","as","a","dominant-negative","cdk2","construct","prevented","HLA","class","I","-mediated","inactivation","of","Rb",";","in","contrast",",","dominant-negative","cdk4","and","cdk6","constructs","had","no","effect","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,0,9,10,10,0,0,0,9,0,0,0,0,1,2,2,2,2,0,0,0,0]}
{"id":"1579","tokens":["B-cell","proliferation","and","induction","of","early","G1-regulating","proteins","by","Epstein-Barr","virus","mutants","conditional","for","EBNA2","."],"ner_tags":[7,0,0,0,0,0,9,10,0,0,0,0,0,0,9,0]}
{"id":"14629","tokens":["A","human","putative","lymphocyte","G0\/G1","switch","gene","homologous","to","a","rodent","gene","encoding","a","zinc-binding","potential","transcription","factor","."],"ner_tags":[0,1,2,2,2,2,2,0,0,0,1,2,0,0,9,10,10,10,0]}
{"id":"13317","tokens":["The","cytokines","IL-4","and","IL-5","are","often","coordinately","produced","by","Th2","cells","as","in","asthma","."],"ner_tags":[0,9,9,0,9,0,0,0,0,0,5,6,0,0,0,0]}
{"id":"9581","tokens":["Competent","transcription","initiation","by","RNA","polymerase","II","in","cell-free","extracts","from","xeroderma","pigmentosum","groups","B","and","D","in","an","optimized","RNA","transcription","assay","."],"ner_tags":[0,0,0,0,9,10,10,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"618","tokens":["The","nuclear","activity","of","NF-kappa","B","is","tightly","regulated","from","the","cytoplasmic","compartment","by","an","inhibitory","subunit","called","I","kappa","B","alpha","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,0,9,10,10,10,0]}
{"id":"8673","tokens":["The","synergy","between","c-Maf","and","JunB","can","be","attributed","to","cooperative","DNA","binding",",","which","is","facilitated","by","JunB","phosphorylation","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"18329","tokens":["Purified","MAR-BP1","migrates","as","a","33-kDa","protein",",","and","it","can","be","found","in","nuclear","matrix","preparations","from","a","number","of","different","types","of","lymphoid","cell","lines","."],"ner_tags":[0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"13210","tokens":["The","Oct","1","transcription","factor",",","and","a","very","close","homologue",",","KIAA0144",",","was","identified","using","the","POU","family","primers","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0]}
{"id":"2220","tokens":["Furthermore",",","it","might","contribute","to","the","hypergammaglobulinemia","or",",","together","with","other","cytokines","found","to","be","dysregulated",",","the","T-helper","cell","dysfunctions","observed","in","AIDS","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3085","tokens":["Nonsteroidal","anti-inflammatory","drugs","such","as","salicylates","have","been","used","to","treat","symptoms","of","inflammation",",","and","a","new","mechanism","of","drug","action","was","suggested","recently","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10083","tokens":["METHODS",":","Cultured","bovine","corneal","endothelium","was","stimulated","for","6","hours","by","40","micron\/ml","tumor","necrosis","factor","alpha","(","TNFalpha",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0]}
{"id":"5397","tokens":["A","2-kb","VDR","cDNA","insert","(","including","the","complete","VDR","coding","region",")","was","cloned","in","an","antisense","orientation","into","the","EBV","episomal","vector","pMEP4","under","the","control","of","an","inducible","promoter","and","transfected","into","U937","."],"ner_tags":[0,1,2,2,2,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,5,0]}
{"id":"13392","tokens":["Characterization","and","understanding","of","the","basic","mechanisms","involved","in","the","different","pathways","protecting","or","leading","to","cell","death","may","provide","novel","ways","to","control","inappropriate","apoptosis","involved","in","several","diseases","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13150","tokens":["These","findings","indicate","that","IL-6","production","and","Stat3","activation","occur","early","in","HS","and","may","contribute","to","PMN-mediated","lung","injury",",","including","ARDS","after","HS","."],"ner_tags":[0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12202","tokens":["These","results","provide","the","first","direct","evidence","for","the","requirement","of","GATA-1","and","NF-E2","in","BA-induced","differentiation","process","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"10916","tokens":["SCF","-mediated","ligation","of","kit\/IL-4R","alpha","is","sufficient","to","elicit","IL-4","-specific","gene","expression",",","including","up-regulation","of","CD23","and","synthesis","of","germ-line","epsilon","transcripts","."],"ner_tags":[9,0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,3,4,4,0]}
{"id":"5532","tokens":["METHODS",":","CD23","was","cross-linked","in","human","monocytes","and","U937","cells","with","IgE","immune","complexes","."],"ner_tags":[0,0,9,0,0,0,7,8,0,5,6,0,9,10,10,0]}
{"id":"3529","tokens":["When","CD45RA+","(","naive",")","and","CD45RO+","(","memory",")","T","lymphocytes","were","directly","stimulated","with","H2O2",",","NF-kappaB","nuclear","translocation","was","stronger","in","naive","cells","than","in","memory","cells","and","it","could","be","induced","with","lower","doses","."],"ner_tags":[0,7,8,8,8,0,7,8,8,8,8,8,0,0,0,0,0,0,9,0,0,0,0,0,7,8,0,0,7,8,0,0,0,0,0,0,0,0,0]}
{"id":"9372","tokens":["In","this","study",",","electrophoretic","mobility","shift","analysis","showed","that","the","Sp1-related","factor",",","Sp3",",","also","binds","at","or","near","these","same","regions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"15137","tokens":["Taken","together",",","our","results","suggest","that","OCA-B","is","a","tissue-",",","promoter-",",","and","factor-specific","coactivator","and","that","OCA-B","may","be","a","major","determinant","for","B","cell-specific","activation","of","immunoglobulin","promoters","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,9,10,10,10,10,10,10,0,0,9,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"9349","tokens":["Both","have","been","shown","to","be","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,9,10,0]}
{"id":"9025","tokens":["X","chromosome","inactivation","and","polymorphism","of","the","human","androgen","receptor","(","HUMARA",")","gene","has","been","applied","for","analyzing","the","clonality","of","blood","cells","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,2,2,2,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"16723","tokens":["Human","T","and","B","lymphocytes","demonstrate","an","early","and","transient","hyperpolarization","after","ligand","binding","."],"ner_tags":[7,8,8,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"16377","tokens":["Although","monocytic","cells","can","provide","a","reservoir","for","viral","production","in","vivo",",","their","regulation","of","human","immunodeficiency","virus","type","1","(","HIV-1",")","transcription","can","be","either","latent",",","restricted",",","or","productive","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12751","tokens":["In","group","I","BL","cells",",","containing","low","levels","of","NF-kappaB",",","only","RBP","binding","was","observed","in","EMSAs",",","whereas","NF-kappaB","binding","could","be","demonstrated","in","EBV-transformed","B","cell","lines","containing","high","levels","of","activated","NF-kappaB","."],"ner_tags":[0,5,6,6,6,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,5,6,6,6,0,0,0,0,0,9,0]}
{"id":"10999","tokens":["This","response","required","at","least","120","min","to","be","evident","and","supershift","experiments","revealed","that","the","NF-kappa","B","complex","contains","both","RelA","and","p50","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,0,9,0]}
{"id":"5946","tokens":["MBP","over","the","concentration","range","of","0.1","to","10","microM","stimulated","the","release","of","up","to","approximately","8","ng\/ml","IL-8","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"917","tokens":["LBF3",",","LBF5",",","LBF6",",","or","LBF7","may","also","be","involved",",","since","their","binding","sites","also","contribute","to","EBNA-2","responsiveness","."],"ner_tags":[9,0,9,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"14751","tokens":["OBJECTIVE",":","To","examine","the","inter-relationship","between","HIV-1","infection","and","the","cell","surface","receptors","for","tumor","necrosis","factor","(","TNF",")","-alpha",",","an","immunoregulatory","cytokine","that","can","enhance","HIV-1","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"8390","tokens":["If","there","is","a","reciprocal","elevation","of","gamma-globin","expression","upon","repression",",","this","approach","could","be","useful","in","additional","hemoglobinopathies","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12234","tokens":["NFATc","overcame","a","blockade","at","reverse","transcription","and","permitted","active","HIV-1","replication","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18008","tokens":["Helices","I","and","II","are","positioned","in","an","antiparallel","mode","and","form","one","arm","of","the","HMG","box","."],"ner_tags":[9,10,10,10,0,0,0,0,9,10,0,0,0,0,0,0,9,10,0]}
{"id":"13556","tokens":["The","TPA-mediated","translocation","of","cPKC-alpha","and","cPKC-betaII","was","not","influenced","by","pretreatment","with","GF","109203X","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"12980","tokens":["These","data","indicate","a","highly","polarized","functional","architecture","for","antigen","processing","and","presentation","by","intestinal","epithelial","cells",",","and","suggest","that","the","functional","outcome","of","antigen","processing","by","the","intestinal","epithelium","is","both","dependent","on","the","cellular","surface","at","which","the","foreign","antigen","is","internalized","and","by","the","underlying","degree","of","mucosal","inflammation"],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9010","tokens":["G.","vaginalis","lysates","also","activated","HIV","expression","in","certain","T","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"2920","tokens":["In","this","report",",","we","describe","the","phenotype","of","mouse","transgenic","lines","obtained","by","inducing","tal-1","protein","expression","in","lymphoid","tissues","using","the","LCK","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,9,10,0,0,0,0,0,0,1,2,0]}
{"id":"12888","tokens":["A","regulatory","element","in","the","CD95","(","APO-1\/Fas",")","ligand","promoter","is","essential","for","responsiveness","to","TCR","-mediated","activation","."],"ner_tags":[0,1,2,0,0,1,2,2,2,2,2,0,0,0,0,0,9,0,0,0]}
{"id":"15277","tokens":["In","this","article",",","transcriptional","regulation","of","the","archetypal","T-cell-specific","gene",",","alpha","TCR",",","is","discussed","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,1,2,0,0,0,0]}
{"id":"3841","tokens":["We","show","by","antibody","supershift","experiments","and","UV","cross-linking","followed","by","denaturing","polyacrylamide","gel","electrophoresis","that","both","CREB","and","ATF","family","members","bind","to","this","region","in","vitro","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12571","tokens":["17beta-estradiol","(","E2",")","markedly","enhanced","lipopolysaccharide","-","(","LPS",")","induced","IL-1beta","promoter","-driven","CAT","activity","in","a","dose-dependent","manner","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,9,0,0,0,0,0,0]}
{"id":"16168","tokens":["However",",","in","either","EL-4","(","T",")","cells","or","S194","cells",",","both","lower-affinity","sites","can","be","significantly","induced","by","the","tax","gene","product","of","human","T-cell","leukemia","virus","type","I",",","showing","that","NF-kappa","B","activity","can","be","modulated","even","in","a","B-cell","line","that","constitutively","expresses","this","factor","."],"ner_tags":[0,0,0,0,5,6,6,6,6,0,5,6,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0]}
{"id":"14622","tokens":["However",",","the","ES","cell","system","can","be","used","as","an","alternative","until","targeted","erythroleukemia","cells","become","available","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0]}
{"id":"286","tokens":["CIITA","mRNA","is","normally","inducible","by","IFN-gamma","in","class","II","non-inducible",",","RB-defective","lines",",","and","in","one","line",",","re-expression","of","RB","has","no","effect","on","CIITA","mRNA","induction","levels","."],"ner_tags":[3,4,0,0,0,0,9,0,5,6,6,6,6,6,0,0,0,0,0,0,0,0,9,0,0,0,0,3,4,0,0,0]}
{"id":"1245","tokens":["In","fact",",","cellular","NF-kappa","B","activity","was","phosphorylation-dependent","and","the","DNA","binding","activity","of","p65-containing","NF-kappa","B","was","enhanced","by","phosphorylation","in","vitro","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"11201","tokens":["Redox","regulation","of","the","mitogen-activated","protein","kinase","pathway","during","lymphocyte","activation","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"2344","tokens":["Two","other","sites","display","disparate","effects","on","IL-2","gene","expression","in","different","T","leukemia","cell","lines",":","the","distal","purine","box","(","-291","to","-277",")","and","the","proximal","purine","box","sites","(","-145","to","-128",")","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,5,6,6,6,0,0,1,2,2,0,1,2,2,0,0,0,1,2,2,2,0,1,2,2,0,0]}
{"id":"3704","tokens":["However",",","the","molecular","mechanisms","involved","in","ATRA-dependent","growth","inhibition","and","cellular","differentiation","are","not","presently","understood","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6261","tokens":["We","found","that","this","latently","infected","cell","line","with","heat","shock","at","42","degrees","C","for","2","h","resulted","in","a","high","level","of","HIV-1","production","without","addition","of","any","cytokines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"5129","tokens":["To","define","novel","proteins","involved","in","the","early","transcriptional","response","during","the","activation","of","human","T","lymphocytes",",","we","used","a","high-resolution",",","two-dimensional","gel","electrophoresis","system","to","identify","nuclear",",","deoxyribonucleic","acid","(","DNA",")","binding","proteins","exhibiting","rapid","changes","in","phosphorylation","following","cell","stimulation","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"15335","tokens":["Mobility","shift","assays","showed","that","addition","of","anti-AIM","mAb","to","PMA-treated","T","lymphocytes","markedly","enhanced","the","binding","activity","of","AP-1","to","its","cognate","sequence",",","the","phorbol","ester","response","element","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,7,8,8,0,0,0,0,0,0,9,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"1178","tokens":["The","intracellular","dioxin","receptor","mediates","signal","transduction","by","dioxin","and","functions","as","a","ligand-activated","transcription","factor","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"1558","tokens":["The","response","of","LFA-3","to","TaxI","induction","was",",","on","the","other","hand",",","relatively","slow","and","weak",",","and","might","be","indirect","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3363","tokens":["Using","in","situ","hybridization","on","sections","from","non","HIV","hyperplastic","lymph","nodes",",","we","found","that","the","gene","of","the","105","kDa","precursor","of","p50","was","overexpressed","in","the","light","zone","of","germinal","centers",",","with","a","network","aspect",",","which","suggested","the","involvement","of","follicular","dendritic","cells","(","FDC",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,7,0,0]}
{"id":"6063","tokens":["Cells","within","each","category","did","not","give","any","aberrant","results","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11130","tokens":["Deletional","analysis","indicated","that","five","Sp1","sites","mediated","basal","expression","in","uninduced","cells","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,7,8,0]}
{"id":"4184","tokens":["Purified","bcl-2","is","cleaved","by","HIV","protease","between","phenylalanine","112","and","alanine","113","."],"ner_tags":[0,9,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"2627","tokens":["In","addition",",","a","new","combination","isoform","containing","Oct2a","'s","amino","terminal","insert","(","exon","7a",")","and","Oct2b","'s","carboxy","terminal","insert","(","exon","13",")","was","found","that","created","a","novel","large","isoform",",","Oct2ab","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,10,0,1,2,0,0,9,10,10,10,10,0,1,2,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"6203","tokens":["Estrogens","also","influence","production","of","mitogens","which",",","when","released","at","sites","of","vascular","injury",",","affect","vascular","remodeling","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7923","tokens":["RXRs","heterodimerize","with","1",",","25-dihydroxyvitamin","D3","[","1",",","25","(","OH",")","2D3","]","receptor","(","VDR",")",",","enabling","their","efficient","transcriptional","activation","."],"ner_tags":[9,0,0,9,10,10,10,10,10,10,10,10,10,10,10,10,10,0,9,0,0,0,0,0,0,0,0]}
{"id":"13129","tokens":["A","new","human","leukemia","cell","line","with","an","eosinophilic","phenotype",",","designated","YJ",",","was","established","from","the","peripheral","blood","cells","of","a","patient","with","chronic","myelomonocytic","leukemia","(","CMMoL",")","with","eosinophilia","."],"ner_tags":[0,0,5,6,6,6,0,0,0,0,0,0,5,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9332","tokens":["This","inhibition",",","which","occurred","with","a","parallel","activation","of","c-Jun","transactivating","functions","and","expression",",","was","reflected","by","transfection","experiments","at","the","IL-2","promoter","level",",","and","involved","not","only","the","inhibition","of","NF-kappaB","-driven","reporter","activation","but","also","that","of","nuclear","factor","of","activated","T","cells","(","NFAT",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,10,10,10,10,0,9,0,0]}
{"id":"5021","tokens":["Tissue-specific","activity","of","the","gammac","chain","gene","promoter","depends","upon","an","Ets","binding","site","and","is","regulated","by","GA-binding","protein","."],"ner_tags":[0,0,0,0,1,2,2,2,0,0,0,1,2,2,0,0,0,0,9,10,0]}
{"id":"8963","tokens":["Antibody","studies","demonstrated","that","in","HUVECs","at","least","75","%","of","the","adhesion","response","is","VCAM-1","mediated","."],"ner_tags":[0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"16871","tokens":["T","lymphocytes","appeared","to","be","an","important","source","of","1",",","25","(","OH",")","2D3","production",",","since","purified","T","lymphocytes","from","all","patients","with","tuberculosis","produced","1",",","25","(","OH",")","2D3",",","and","1",",","25","(","OH",")","2D3","production","by","these","cells","correlated","closely","with","that","produced","by","unseparated","lavage","cells","."],"ner_tags":[7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"4852","tokens":["We","have","now","elucidated","the","mechanism","by","which","CNI-1493","inhibits","macrophage","TNF","synthesis","and","show","here","that","it","acts","through","suppression","of","TNF","translation","efficiency","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"9708","tokens":["The","inhibition","of","apoptosis","by","curcumin","in","rat","thymocytes","was","accompanied","by","partial","suppression","of","AP-1","activity","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,9,0,0]}
{"id":"11644","tokens":["IL-12","and","type","I","but","not","type","II","interferons","induce","expression","of","the","IL-12R","beta","2","chain","during","in","vitro","T","cell","differentiation","after","antigen","receptor","triggering","."],"ner_tags":[9,0,9,10,10,10,10,10,10,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14903","tokens":["The","presence","of","c-fos","had","a","negative","influence","on","GR","function","and","correlated","with","the","cell-specific","synergistic","or","antagonistic","activity","of","Jun","with","respect","to","GR",";","high","basal","expression","of","c-fos","as","well","as","AP-1","DNA","binding","and","transcriptional","activity","were","observed","in","HeLa","cells",",","but","not","in","T","cells","."],"ner_tags":[0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,5,6,0,0,0,0,7,8,0]}
{"id":"3905","tokens":["The","activated","form","of","the","interferon-induced","transcription","factor","complex","ISGF3","was","also","detected","in","nuclear","extracts","from","uninduced","cells","."],"ner_tags":[0,0,0,0,0,9,10,10,10,9,0,0,0,0,0,0,0,5,6,0]}
{"id":"1737","tokens":["These","results","suggest","that","the","two","transcription","factors","are","independently","regulated","and","may","perform","different","functions","during","T-cell","activation","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14856","tokens":["Neither","Bt2cAMP","nor","PMA","individually","mediated","these","sustained","effects",",","which","therefore","appear","as","a","consequence","of","the","interplay","between","both","metabolic","stimuli","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2559","tokens":["Site","D","(","nt","4816","to","4851",")","specifically","bound","a","ubiquitously","expressed","factor","."],"ner_tags":[1,2,0,1,2,2,2,0,0,0,0,9,10,10,0]}
{"id":"5601","tokens":["This","study","has","investigated","DHEA","modulation","of","LPS-induced","monocyte","cytotoxicity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8078","tokens":["RESULTS",":","In","FH","and","HIV","adenopathy",",","staining","for","Bcl-6","revealed","densely","populated","GCs","with","well-defined","and","regular","GC","borders",",","whereas","Bcl-6+","cells","were","rare","in","the","interfollicular","areas","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"890","tokens":["Thus",",","Mn-SOD","RNA","protein","levels","and","activity","were","markedly","reduced","in","the","presence","of","Tat","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"7353","tokens":["An","essential","role","for","NF-kappaB","in","human","CD34","(","+",")","bone","marrow","cell","survival","."],"ner_tags":[0,0,0,0,9,0,7,8,8,8,8,8,8,8,0,0]}
{"id":"4767","tokens":["Like","other","cytokines",",","IL-12","mediates","its","biologic","activity","through","high-affinity","receptors","expressed","on","responsive","cells","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"2919","tokens":["In","human","pathology",",","the","TAL-1","gene","product","is","expressed","in","a","high","percentage","of","T-cell","acute","lymphoblastic","leukemias","in","the","pediatric","age","range",";","however",",","it","has","not","been","established","whether","the","expression","has","a","causal","role","in","oncogenesis","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3290","tokens":["Sequence","analysis","and","expression","in","cultured","lymphocytes","of","the","human","FOSB","gene","(","G0S3",")","."],"ner_tags":[0,0,0,0,0,7,8,0,0,0,1,2,0,1,0,0]}
{"id":"10691","tokens":["Interestingly",",","an","inducible","footprint","between","-183","and","-196","was","consistently","observed","in","Jurkat","T","cells","and","CD45RA","and","CD45R0","T","helper","subsets","upon","stimulation","with","phorbol","12-myristate","13-acetate+","phytohemagglutinin","(","PMA+","PHA",")","that","was","highly","sensitive","to","treatment","with","corticosteroids","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,0,0,5,6,6,0,7,8,8,8,8,8,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"8046","tokens":["In","addition",",","this","technique","should","permit","dissection","of","a","full","range","of","cellular","signaling","pathways","at","the","protein","level","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13393","tokens":["Cross-priming","of","CTL","responses","in","vivo","does","not","require","antigenic","peptides","in","the","endoplasmic","reticulum","of","immunizing","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"10520","tokens":["Eed","binds","to","K","protein","through","a","domain","in","its","N","terminus",",","but","interestingly",",","this","domain","is","not","found","in","the","Drosophila","Esc","."],"ner_tags":[9,0,0,9,10,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"5363","tokens":["The","1.955-kb","viral","segment","includes","a","dyad","symmetry","region","located","between","two","small","nuclear","RNA","genes","and","is","located","upstream","of","the","dihydrofolate","reductase","gene","homolog","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"14771","tokens":["Calcium","dependent","activation","of","the","NF-AT","transcription","factor","by","p59fyn","."],"ner_tags":[0,0,0,0,0,9,10,10,0,9,0]}
{"id":"17206","tokens":["The","formation","of","this","complex","also","requires","both","AP-1","sites","and","correlates","with","maximal","enhancer","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,1,0,0]}
{"id":"14236","tokens":["The","expression","of","thrombospondin","1","(","TSP","1",")",",","a","member","of","the","TSP","gene","family",",","is","rapidly","induced","by","growth","factors","."],"ner_tags":[0,0,0,9,10,0,9,10,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0]}
{"id":"199","tokens":["Rather",",","hEpoR","transcription","activity","depends","on","coordination","between","Sp1","and","GATA-1","with","other","cell-specific","factors",",","including","possibly","other","Sp1-like","binding","proteins",",","to","provide","high","level",",","tissue-specific","expression","."],"ner_tags":[0,0,9,0,0,0,0,0,0,9,0,9,0,0,9,10,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"7045","tokens":["METHODS",":","Twenty-two","patients","with","severe","restrictive","anorexia","nervosa",",","10","patients","with","active","Cushing","'s","disease",",","and","24","healthy","volunteers","without","psychiatric","disorders","or","mood","alterations","were","investigated","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1718","tokens":["In","three","patients","with","PHP","who","were","subjected","to","parathyroidectomy",",","the","calcitriol","number","came","down","to","normal","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7228","tokens":["The","organized","structure","of","the","secondary","lymphoid","tissues","is","thought","to","enhance","the","sensitivity","of","antigen","recognition","and","to","support","proper","regulation","of","the","activation","and","maturation","of","the","antigen-responsive","lymphoid","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"9292","tokens":["Constitutive","expression","c-fos",",","c-jun",",","and","NF","kappa","B","mRNA","is","in","nucleated","fetal","blood","cells","and","up-regulation","of","c-fos","and","c-jun","with","anti-CD3","stimulation","."],"ner_tags":[0,0,3,4,4,4,4,4,4,4,4,0,0,7,8,8,8,0,0,0,9,0,9,0,9,0,0]}
{"id":"16884","tokens":["A","block","to","RNA","elongation","is","largely","responsible","for","decreased","c-myc","transcription","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,0]}
{"id":"14091","tokens":["These","findings","suggest","that","LTR","sequence","changes","can","significantly","affect","basal","LTR","function","and","transcription","factor","recruitment",",","which","may",",","in","turn",",","alter","the","course","of","viral","replication","in","cells","of","CNS","and","immune","system","origin","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,1,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2866","tokens":["These","findings","suggest","that","Zp","responds","directly","to","changes","in","the","activity","of","both","PKC","and","calcium\/calmodulin-dependent","protein","kinase","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,0,9,0,9,10,10,0]}
{"id":"6570","tokens":["New","strategies","that","attenuate","via","mechanisms","distinct","from","loss-of-function","are","needed","for","enhancing","the","safety","phenotype","of","viral","genome","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"10206","tokens":["The","human","myeloid","nuclear","differentiation","antigen","(","MNDA",")","is","expressed","specifically","in","maturing","cells","of","the","myelomonocytic","lineage","and","in","monocytes","and","granulocytes","."],"ner_tags":[0,9,10,10,10,10,0,9,0,0,0,0,0,7,8,0,0,0,0,0,0,7,0,7,0]}
{"id":"17071","tokens":["The","adenovirus","early","region","3","(","ES",")","gene","products","are","involved","in","the","maintenance","of","viral","persistence","by","complexing","with","the","class","I","MHC","antigens",",","thus","preventing","their","cell","surface","expression","with","a","resultant","decrease","in","host","immunologic","destruction","."],"ner_tags":[0,9,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3421","tokens":["RT-PCR","demonstrated","that","NL","of","both","subtypes","expressed","EBNAI","of","the","QUK","splice","pattern",",","the","latent","membrane","proteins",",","LMP1","and","2","and","the","BamHI","A","rightward","transcripts","in","the","absence","of","EBNA2","mRNAs",",","compatible","with","the","latency","type","II","pattern","."],"ner_tags":[0,0,0,7,0,0,0,0,9,0,0,0,0,0,0,0,9,10,10,0,9,10,10,0,0,3,4,4,4,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0]}
{"id":"18189","tokens":["Elevated","levels","of","several","inflammatory","cytokines","have","been","detected","in","the","sera","of","HIV-1-infected","individuals","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"13573","tokens":["All","Rights","Reserved","."],"ner_tags":[0,0,0,0]}
{"id":"4503","tokens":["The","findings","suggest","that","a","novel","proto-oncogene","in","the","vicinity","of","TCR","alpha\/delta","is","involved","in","this","translocation","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,1,2,0,0,0,0,0,0]}
{"id":"7929","tokens":["Associated","with","these","findings",",","the","levels","of","p21","(","WAF1\/CIP1",")","and","p27","(","KIP1",")","mRNA","and","protein","increased","in","these","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,0,3,4,4,4,4,0,0,0,0,0,0,0]}
{"id":"15432","tokens":["For","further","mapping","purposes",",","a","fusion","promoter","was","constructed","with","the","granulocyte\/macrophage","colony-stimulating","factor","basic","promoter","containing","60","base","pairs","of","sequence","upstream","from","the","cap","site","of","the","mouse","granulocyte\/macrophage","colony-stimulating","factor","gene","and","various","lengths","of","the","5","'","upstream","sequence","of","the","IL-4","gene","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,0,0,1,2,2,2,2,0,1,2,2,2,2,0,0,0,1,2,0,0,1,2,2,2,2,0,0,0,0,0,1,2,2,2,0,0,1,2,0]}
{"id":"3310","tokens":["Susceptibility","of","these","transformed","cell","lines","to","NK","cells","was","determined","by","cytolytic","assays","."],"ner_tags":[0,0,0,0,5,6,0,7,8,0,0,0,0,0,0]}
{"id":"9080","tokens":["Furthermore",",","the","ability","to","suppress","IL-1RI","and","IL-1RII","mRNA","levels","was","not","unique","to","IFN-gamma","because","IL-10","also","inhibited","expression","of","these","genes","in","IL-4\/IL-13-stimulated","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,5,6,0]}
{"id":"12232","tokens":["Activation","of","unknown","host","intracellular","events","overcomes","such","inhibitory","steps","and","is","concomitant","with","HIV-1","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8047","tokens":["Activation","of","nuclear","factor-kappaB","by","lipopolysaccharide","in","mononuclear","leukocytes","is","prevented","by","inhibitors","of","cytosolic","phospholipase","A2","."],"ner_tags":[0,0,9,10,0,0,0,7,8,0,0,0,0,0,9,10,10,0]}
{"id":"239","tokens":["Previous","work","has","shown","that","in","Jurkat","T","cells",",","a","set","of","widely","expressed","transcription","factors","(","the","ICK-1","family",")","affect","the","GOS19","promoter","."],"ner_tags":[0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,9,10,0,0,9,10,0,0,0,1,2,0]}
{"id":"9851","tokens":["Analysis","of","erythroblasts","co-expressing","Spi-1","and","the","wild-type","mouse","EpoR","showed","that","differentiation","arrest","and","inhibition","of","apoptosis","depended","on","specific","cooperation","between","Spi-1","and","EpoR","(","R129C",")","."],"ner_tags":[0,0,0,0,9,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,10,10,0]}
{"id":"2833","tokens":["While","Jurkat","cells","co-expressed","two","discrete","cell-surface","isoforms","of","CD43",",","recognized","by","mAb","J393","and","mAb","G10-2",",","respectively",",","only","J393\/CD43","signaled","apoptosis","."],"ner_tags":[0,5,6,0,0,0,9,10,0,9,0,0,0,9,10,0,9,10,0,0,0,0,9,0,0,0]}
{"id":"13743","tokens":["Taken","together","these","results","suggest","that","gamma-interferon","mediated","cell","activation","is","responsible","for","STAT1alpha","-induced","transcription","of","the","IP-10","gene","in","THP-1","macrophages","as","well","as","in","monocytes","from","II-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,5,6,0,0,0,0,7,0,5,0]}
{"id":"3816","tokens":["In","this","study","we","show","that","the","structurally","unrelated","antioxidant","agents","pyrrolidine","dithiocarbamate","(","PDTC",")",",","butylated","hydroxyanisole",",","and","Nacetylcysteine","activated","JNK","(","c-Jun","NH2-terminal","kinase",")","in","Jurkat","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,10,0,0,5,6,6,0]}
{"id":"18042","tokens":["Its","expression","was","always","restricted","to","the","nucleus","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"10709","tokens":["This","effect","was","confirmed","in","COS-7","cells","transfected","with","the","cDNA","of","CCK","(","B",")","receptor","cloned","from","Jurkat","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,5,6,6,0]}
{"id":"11941","tokens":["Pertussis","toxin","blocked","FMLP","-induced","activation","of","the","p42\/44","(","ERK",")","MAPk","cascade",",","but","not","that","of","p38","MAPk","."],"ner_tags":[9,10,0,9,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,9,10,0]}
{"id":"9862","tokens":["OBJECTIVE",":","We","investigated","the","production","of","IL-5",",","a","potent","growth","factor","and","chemotactic","factor","for","eosinophils",",","by","CD4+","T","lymphocytes","in","patients","with","asthma","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,7,0,0,7,8,8,0,0,0,0,0]}
{"id":"6830","tokens":["A","cell","culture","system","was","then","employed","that","permitted","the","differentiation","of","Th","effectors","from","resting","memory","T","cells","by","short","term","priming","."],"ner_tags":[0,5,6,6,0,0,0,0,0,0,0,0,9,10,0,7,8,8,8,0,0,0,0,0]}
{"id":"553","tokens":["In","the","present","study","we","analyzed","the","control","of","IL-2","promoter","activity","in","Epstein-Barr","virus","(","EBV",")","-transformed","B","cell","clones","which","are","capable","of","secreting","IL-2","at","a","low","level","after","stimulation","with","phorbol","12-myristate","13-acetate","and","the","Ca2+","ionophore","ionomycin","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,5,6,6,6,6,6,6,6,6,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15801","tokens":["The","v-erb","A","oncogene","of","avian","erythroblastosis","virus","is","a","mutated","and","virally","transduced","copy","of","a","host","cell","gene","encoding","a","thyroid","hormone","receptor","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,9,10,10,0]}
{"id":"4249","tokens":["Analysis","of","the","accumulation","of","mRNA-encoding","members","of","the","AP-1","transcription","factor","family","demonstrated","that","c-fos","and","junB","are","also","expressed","upon","stimulation","of","NK","and","T","cells","with","IL-2",",","but","not","IL-12",",","whereas","expression","of","c-jun","and","junD","is","not","modified","by","either","cytokine","."],"ner_tags":[0,0,0,0,0,9,10,0,0,9,10,10,10,0,0,1,0,1,0,0,0,0,0,0,7,8,8,8,0,9,0,0,0,9,0,0,0,0,1,0,1,0,0,0,0,0,9,0]}
{"id":"5637","tokens":["The","combination","of","dopamine","and","TNF-alpha","led","to","a","stimulation","of","HIV-1","transcription","and","replication","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"12747","tokens":["Using","RT-PCR",",","IL-1beta","was","shown","to","be","up-regulated","in","EBV-transformed","LCLs","as","well","as","in","group","III","Burkitt","'s","lymphoma","(","BL",")","cell","lines",",","compared","with","group","I","BL","cell","lines","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,5,6,0,0,0,0,5,6,6,6,6,6,6,6,6,6,0,0,0,5,6,6,6,6,0]}
{"id":"7123","tokens":["Here",",","we","investigate","the","role","of","Rho","in","regulating","the","distribution","of","the","monocyte-binding","receptors","E-selectin",",","ICAM-1",",","and","VCAM-1","in","human","endothelial","cells","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,9,0,9,0,0,9,0,7,8,8,0]}
{"id":"5039","tokens":["Detection","of","various","other","intracellular","signaling","proteins","is","also","described","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0]}
{"id":"1296","tokens":["Only","p50","NF-kappa","B","protein","bound","the","kappa","B","element","of","interleukin-2","receptor","(","IL-2R",")","alpha","chain","promoter","on","resting","T","cells","."],"ner_tags":[0,9,10,10,10,0,0,1,2,2,0,1,2,2,2,2,2,2,2,0,0,7,8,0]}
{"id":"14860","tokens":["Tax-expressing","cell","lines","produce","LT","biologic","activity","."],"ner_tags":[5,6,6,0,9,0,0,0]}
{"id":"16721","tokens":["Charybdotoxin-sensitive",",","Ca","(","2+",")","-dependent","membrane","potential","changes","are","not","involved","in","human","T","or","B","cell","activation","and","proliferation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0]}
{"id":"14528","tokens":["We","now","demonstrate","that","nuclear","expression","of","human","c-Rel",",","which","is","induced","by","either","phorbol","ester","or","tumor","necrosis","factor","alpha","with","delayed","kinetics","relative","to","p65",",","markedly","represses","p65","-mediated","activation","of","these","transcription","units","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"1051","tokens":["In","order","to","investigate","the","mechanism","of","the","regulation","of","cdc2","mRNA","expression","in","hematopoietic","cells",",","we","isolated","the","5'-flanking","sequence","of","the","cdc2","gene","and","found","the","putative","E2F","binding","site","at","the","position","of","nucleotides","-124","to","-117","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,3,4,0,0,7,8,0,0,0,0,1,2,0,0,1,2,0,0,0,0,0,1,2,0,0,0,0,1,2,2,2,0]}
{"id":"13461","tokens":["IFN-gamma","increased","the","surface","expression","of","class","II","molecules","in","THP-1","cells","and","this","was","markedly","reduced","in","cells","infected","with","M.","tuberculosis","."],"ner_tags":[9,0,0,0,0,0,9,10,10,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5366","tokens":["Anergy","is","a","major","mechanism","to","ensure","antigen-specific","tolerance","in","T","lymphocytes","in","the","adult","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0]}
{"id":"14435","tokens":["Deletion","and","base","substitution","mutations","along","with","DNA","binding","studies","demonstrated","that","the","enhancer","contained","a","minimum","of","three","functional","protein","binding","sequences",",","two","of","which","appeared","to","be","important","for","gene","induction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13630","tokens":["Together",",","these","studies","demonstrate","that","HTLV-1","Tax","exploits","a","distal","part","of","the","proinflammatory","cytokine","signaling","cascade","leading","to","induction","of","NF-kappaB","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,0]}
{"id":"2537","tokens":["These","differences","may","represent","different","regulatory","pathways","of","the","two","cell","systems","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6828","tokens":["To","test","whether","disordered","memory","T","cell","differentiation","contributes","to","the","typical","Th1-dominated","chronic","inflammation","in","RA","we","investigated","differentiation","of","resting","CD4+","memory","T","cells","in","patients","with","early","(","6","wk","to","12","mo",")","untreated","RA","and","in","age-","and","sex-matched","healthy","controls","in","vitro","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18152","tokens":["We","could","also","show","Pu","box","-dependent","transactivation","of","a","reporter","gene","in","transient","transfections","in","these","cell","lines","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"16973","tokens":["In","the","main","model","reported","here",",","we","found","that","a","significant","amount","of","NK","activity","variance","could","be","explained","by","five","variables","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1642","tokens":["This","element","had","maximal","activity","in","lymphoid","cells",",","paralleling","the","cell","type","specificity","of","Elf-1","expression","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,9,0,0]}
{"id":"17121","tokens":["A","novel","B-cell-specific","transcription","factor",",","BSAP",",","was","identified","as","a","mammalian","homolog","of","the","sea","urchin","protein","TSAP",",","which","interacts","with","the","promoters","of","four","tissue-specific","late","histone","H2A-2","and","H2B-2","genes","."],"ner_tags":[0,0,9,10,10,0,9,0,0,0,0,0,9,10,0,0,9,10,10,9,0,0,0,0,0,1,0,0,1,2,2,2,2,2,2,0]}
{"id":"14235","tokens":["A","serum","response","element","and","a","binding","site","for","NF-Y","mediate","the","serum","response","of","the","human","thrombospondin","1","gene","."],"ner_tags":[0,1,2,2,0,0,1,2,2,2,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"15859","tokens":["(","ABSTRACT","TRUNCATED","AT","250","WORDS",")"],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"15048","tokens":["These","results","indicate","that","defective","recruitment","of","NF-kappa","B","may","underlie","Nef","'s","negative","transcriptional","effects","on","the","HIV-1","and","interleukin","2","promoters","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,9,0,0,0,0,0,0,1,2,2,2,2,0]}
{"id":"1473","tokens":["Altogether","these","data","indicate","that",",","in","7TD1","cells",",","IL-6","controls","junB","transcription","in","a","biphasic","fashion","by","means","of","two","separate","transduction","pathways","."],"ner_tags":[0,0,0,0,0,0,0,5,6,0,9,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7645","tokens":["These","cells","are","deficient","in","FasL","expression","and","apoptosis","induced","upon","TCR","triggering",",","although","their","cytokine","(","IL-2","and","IFN-gamma",")","production","is","normal","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"10965","tokens":["Whereas","mutations","in","the","GATA-3","site","abolished","antigen-","or","cAMP-","stimulated","IL-5","promoter","activation","in","Th2","cells",",","ectopic","expression","of","GATA-3","in","Th1","cells","or","in","a","non-lymphoid",",","non-IL-5-producing","cell","line","activated","the","IL-5","promoter","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,7,8,0,0,0,5,6,6,6,6,0,0,1,2,0]}
{"id":"17074","tokens":["Each","of","these","domains","possessed","strong","homology","to","motifs","previously","found","to","bind","the","cellular","factor","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"17575","tokens":["This","cDNA","clone","was","isolated","by","expression","cDNA","cloning",",","and","encodes","the","human","c-Jun","protein",",","which","together","with","c-Fos","forms","the","heterodimeric","activator","protein-1","transcription","complex","."],"ner_tags":[0,1,2,0,0,0,0,1,0,0,0,0,0,9,10,10,0,0,0,0,9,0,0,9,10,10,10,10,0]}
{"id":"3743","tokens":["Our","results","therefore","show","that","allele","loss","on","chromosome","20q","in","polycythemia","vera","does","not","commonly","involve","mitotic","recombination","or","chromosome","loss","and","that","microsatellite","instability","is","a","rare","event","in","this","disorder","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"983","tokens":["The","expression","of","the","genes","persisted","in","peripheral","lymph","nodes","of","adult","mice","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5341","tokens":["Nonmitogenic","T","cell","stimulation","did","not","result","in","appearance","of","NF-MATp35","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"7322","tokens":["Since","1988",",","several","families","of","functionally","important","T","cell","transcription","factors","have","been","identified","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0]}
{"id":"4677","tokens":["Within","the","above","region",",","the","fragment","spanning","nucleotides","-158","to","-90","was","required","for","optimal","transcription","in","monocytic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,7,8,0]}
{"id":"6223","tokens":["The","primary","IL-13","receptor","complex","on","human","monocytes","is","believed","to","be","a","heterodimer","comprised","of","the","IL-4R","alpha","chain","and","the","IL-2R","gamma","chain","(","gamma","(","c",")",")","-like","molecule",",","IL-13R","alpha1","."],"ner_tags":[0,0,9,10,10,0,7,8,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,10,10,9,10,10,10,10,10,10,10,0,9,10,0]}
{"id":"488","tokens":["IL-10","treatment","of","both","T","cells","and","monocytes","results","in","the","ligand-induced","tyrosine","phosphorylation","of","tyk2","and","Jak1",",","but","not","Jak2","or","Jak3","."],"ner_tags":[9,0,0,0,7,8,0,7,0,0,0,0,0,0,0,9,0,9,0,0,0,9,0,9,0]}
{"id":"6158","tokens":["Each","volunteer","performed","these","exercise","twice",",","following","either","an","intravenous","injection","of","phosphocreatine","(","PCr",")","or","a","placebo","of","an","isotonic","NaCl","solution","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5813","tokens":["Altogether",",","these","results","suggest","that","atypical","PKC","isoenzymes",",","including","PKC-zeta",",","participate","in","the","signal","transduction","pathways","by","which","HIV","infection","results","in","the","activation","of","NF-kappa","B","in","human","monocytic","cells","and","macrophages","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,8,8,0,7,0]}
{"id":"11629","tokens":["Presentation","of","viral","peptide","and","protein","segregated","with","DQA1","allele",",","because","cell","lines","bearing","DQA1*0501\/DQB1*0201","heterodimers","presented","antigen","in","proliferation","and","cytotoxicity","assays","much","more","efficiently","than","cell","lines","bearing","DQA1*0201\/DQB1*0201","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,5,6,0,9,0]}
{"id":"15191","tokens":["Influence","of","estradiol","and","tamoxifen","on","susceptibility","of","human","breast","cancer","cell","lines","to","lysis","by","lymphokine-activated","killer","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,6,0,0,0,7,8,8,0]}
{"id":"15675","tokens":["Bcl-3","may","therefore","aid","activation","of","select","NF-kappa","B-regulated","genes",",","including","those","of","the","human","immunodeficiency","virus","."],"ner_tags":[9,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0]}
{"id":"10573","tokens":["Of","these",",","we","observed","that","another","transcription","factor","(","AP-1",")","is","also","robustly","induced","at","the","DNA-binding","level","during","macrophage-like","HL-60","differentiation",",","but","not","during","granulocytic","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1972","tokens":["We","have","identified","and","characterized","a","novel","serine\/threonine","kinase","that","phosphorylated","the","proto-oncogene","product",",","c-Fos",",","and","is","termed","Fos","kinase","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,9,10,0,9,0,0,0,0,9,10,0]}
{"id":"12460","tokens":["Heat-shock","for","2","hours","at","42","degrees","C",",","or","the","administration","for","3","hours","of","100","or","150","microM","cadmium","chloride",",","inhibited","the","subsequent","proliferation","activity",",","induced","the","expression","of","functional","differentiation","markers",",","and","caused","an","increase","in","the","amount","of","the","stress-responsive","HSP70","protein","in","U-937","human","promonocytic","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,10,0,5,6,6,6,0]}
{"id":"15587","tokens":["The","genes","and","mechanisms","that","control","programmed","cell","death","are","currently","the","subject","of","intense","study","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14820","tokens":["One","signal","can","be","delivered","by","the","antigen-specific","T-cell","receptor",",","and","the","second","signal","is","provided","by","the","costimulatory","molecule","(","s",")","delivered","by","the","antigen-presenting","cell","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"13747","tokens":["Accumulating","data","from","a","number","of","laboratories","have","recently","indicated","that","the","response","of","transcription","factor","NF-kappaB","to","alterations","in","the","redox","homeostasis","of","cells","may","play","an","important","role","in","modulating","immune","function","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12603","tokens":["The","p50","and","p65","proteins",",","constituents","of","the","prototypic","nuclear","factor","kappaB",",","were","identified","as","components","of","the","DNA-protein","complexes","by","anti-peptide","antibodies","in","gel","supershift","assays","."],"ner_tags":[0,9,10,10,10,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"8215","tokens":["The","work","reported","here","was","instigated","to","identify","additional","VDR","3'-UTR","polymorphisms","that","may","have","functional","significance","and","to","then","test","whether","these","genetic","variants","alter","message","stability","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11333","tokens":["IL-4","is","secreted","by","activated","Th2","but","not","Th1","cells","and","plays","a","major","role","in","the","immune","response","by","modulating","the","differentiation","of","naive","Th","cells","toward","the","Th2","phenotype","."],"ner_tags":[9,0,0,0,0,7,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,7,8,0]}
{"id":"1302","tokens":["Similarly",",","cycloheximide","prevented","the","p65","and","c-rel","translocation","and","consequent","formation","of","active","binding","heterodimers",",","at","early","and","late","times","."],"ner_tags":[0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11110","tokens":["To","get","further","insights","into","the","molecular","mechanisms","underlying","the","biological","activity","of","Tat",",","we","investigated","the","effect","of","endogenous","and","exogenous","Tat","protein","on","c-fos","gene","expression","in","T","lymphoblastoid","(","Jurkat",")","and","monocytic","(","U937",")","cell","lines",",","as","well","as","in","primary","peripheral","blood","mononuclear","cells","(","PBMC",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,5,6,6,6,6,6,6,6,6,6,6,6,0,0,0,0,0,7,8,8,8,8,0,7,0,0]}
{"id":"10244","tokens":["These","included","both","p50\/p50","and","p50\/p65","dimers",",","recognized","by","specific","antibodies","in","EMSA","."],"ner_tags":[0,0,0,9,0,9,10,0,0,0,9,10,0,0,0]}
{"id":"8696","tokens":["We","previously","demonstrated","that","GRbeta","could","antagonize","GRalpha","-mediated","transactivation","of","a","glucocorticoid-responsive","element","(","GRE",")","-driven","reporter","gene","in","COS-7","cells","."],"ner_tags":[0,0,0,0,9,0,0,9,0,0,0,0,1,2,2,2,2,2,2,2,0,5,6,0]}
{"id":"8456","tokens":["These","results","indicate","that","the","adhesion","of","RA","synovial","cells","to","matrices","such","as","hyaluronic","acid","through","CD44","could","up-regulate","VCAM-1","expression","and","VCAM-1","-mediated","adhesion","to","T","cells",",","which","might","in","turn","cause","activation","of","T","cells","and","synovial","cells","in","RA","synovitis","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,9,0,0,9,0,0,9,0,0,0,7,8,0,0,0,0,0,0,0,0,7,8,0,7,8,0,0,0,0]}
{"id":"4296","tokens":["Cell","activation","resulted","in","a","delayed","induction","of","STAT","DNA-binding","activity",",","which","was","sustained","for","several","days",",","was","composed","predominantly","of","Stat1","and","Stat3",",","and","was","blocked","by","cycloheximide","and","actinomycin","D","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"4368","tokens":["Transcriptional","induction","of","the","RAR","(","alpha",")","and","PML-RAR","mRNAs","is","rapid","and","it","is","parallelled","by","an","increase","in","the","corresponding","proteins","."],"ner_tags":[0,0,0,0,3,4,4,4,4,4,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5061","tokens":["Interleukin-13","(","IL-13",")","and","IL-4","are","cytokines","produced","by","T","cells","that","are","encoded","by","the","q23-31","region","of","human","chromosome","5","."],"ner_tags":[9,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11145","tokens":["Nuclear","factor-kappaB","activation","in","human","monocytes","stimulated","with","lipopolysaccharide","is","inhibited","by","fibroblast","conditioned","medium","and","exogenous","PGE2","."],"ner_tags":[9,10,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4786","tokens":["In","part",",","this","may","be","due","to","altered","intercellular","signalling","systems","and","intracellular","signal","transduction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9136","tokens":["During","this","process",",","IL-6","downregulated","expression","of","BCL2","in","1A9-M","cells","and","stimulated","BCL-XL","expression",",","but","had","no","effect","on","p53",",","Bax",",","or","Bak","gene","expression","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"509","tokens":["CD30",",","a","member","of","the","tumor","necrosis","factor","(","TNF",")","receptor","family",",","is","expressed","constitutively","on","the","surface","of","the","human","T","cell","line","ACH-2",",","which","is","chronically","infected","with","human","immunodeficiency","virus","type-1","(","HIV",")","-1","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3384","tokens":["Although","NF-ATp","copurifies","with","NF-ATc",",","there","is","as","yet","no","understanding","of","how","NF-ATp","is","functioning","in","vivo","."],"ner_tags":[0,9,0,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"14805","tokens":["Proliferation","to","tetanus","toxoid","did","not","differ","significantly","between","the","groups","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8278","tokens":["The","pocket","protein-E2F","complexes","are","convergence","points","for","cell","cycle","signaling","."],"ner_tags":[0,9,10,10,0,0,0,0,0,0,0,0]}
{"id":"9807","tokens":["These","data","suggest","a","model","in","which","CD30","limits","its","own","ability","to","transduce","cell","survival","signals","through","signal-coupled","depletion","of","TRAF2","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"16052","tokens":["This","protein","reduces","or","abolishes","in","vitro","the","DNA","binding","activity","of","wild-type","proteins","of","the","same","family","(","KBF1\/p50",",","c-","and","v-rel",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,0,9,10,10,0,0]}
{"id":"482","tokens":["Co-expression","of","Ras","and","calcineurin",",","however",",","did","not","activate","the","GM-CSF","promoter",",","but","required","the","additional","expression","of","NF-kappa","B","p65","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"8984","tokens":["Limited","proteolysis","for","assaying","ligand","binding","affinities","of","nuclear","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8096","tokens":["Our","results","showed","that","HCMV","binding","to","monocytes","resulted","in","the","production","and","release","of","IL-1beta","protein","."],"ner_tags":[0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,9,10,0]}
{"id":"15391","tokens":["Also","co-transfections","of","the","wild-type","promoter","construct","with","an","AP-1\/c-jun","expression","vector","resulted","in","augmented","basal","and","PMA-induced","promoter","activity","."],"ner_tags":[0,0,0,0,1,2,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0]}
{"id":"1035","tokens":["HS","II","was","weak","in","hematopoietic","cell","lines",",","absent","in","Hela",",","and","greatly","enhanced","in","Jurkat",",","suggesting","that","this","region","might","be","implicated","in","the","cis-activation","of","tal-1","promoter","1b","in","this","cell","line","."],"ner_tags":[1,2,0,0,0,5,6,6,0,0,0,5,0,0,0,0,0,5,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0]}
{"id":"11183","tokens":["A","PMLRARalpha","transgene","initiates","murine","acute","promyelocytic","leukemia","."],"ner_tags":[0,1,2,0,0,0,0,0,0]}
{"id":"3761","tokens":["These","data","along","with","previous","observations","demonstrating","the","potent","immunosuppressive","activity","of","TGF-beta","2",",","support","a","model","for","a","feedback","mechanism","between","the","activated","T-lymphocytes","and","astrocytes","via","TGF-beta","2","to","regulate","the","immune","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,7,0,7,0,9,10,0,0,0,0,0,0]}
{"id":"15086","tokens":["The","results","show","that","eicosanoid","synthesis","in","material","from","mammary","cancer","patients","is","different","from","that","in","benign","mammary","tissue","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15274","tokens":["These","results","indicate","that","activation","of","c-fos","is","involved","in","IL","6","-induced","differentiation","of","SKW","6.4","cells","into","IgM-secreting","cells","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,9,10,0,0,0,5,6,6,0,5,6,0]}
{"id":"12384","tokens":["The","effect","of","both","cytokines","on","the","monocyte","maturation\/differentiation","(","CD11b",",","CD13",",","and","CD26",")","and","other","macrophage","markers","(","CD14","and","CD68",")","was","examined","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,0,9,0,0,9,0,0,0,9,10,0,9,0,9,0,0,0,0]}
{"id":"18250","tokens":["In","this","report",",","we","show","that","following","incubation","of","L540","cells","(","Hodgkin","'s","disease-derived",",","T","cell-like",",","CD30+","cells",")","with","the","agonistic","anti-CD30","monoclonal","antibodies","(","mAb",")","M44","and","M67",",","two","nuclear","factor","(","NF",")","-kappa","B","DNA","binding","activities","were","induced","in","nuclear","extracts",",","as","determined","in","gel","retardation","assays","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,5,6,6,6,6,6,6,6,6,0,0,0,9,10,10,10,0,9,0,9,0,9,0,0,9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12253","tokens":["RESULTS",":","Co-culture","of","NK","cells","with","transfected","EC","enhanced","E-selectin",",","IL-8",",","and","NF-kappaB","-dependent","promoter","activity","."],"ner_tags":[0,0,0,0,7,8,0,0,7,0,9,0,9,0,0,9,0,0,0,0]}
{"id":"9470","tokens":["Consequently",",","these","results","suggest","that","physiologically","relevant","concentrations","of","ethanol","may","affect","production","of","inflammatory","cytokines",",","such","as","tumor","necrosis","factor-alpha",",","interleukin-1","beta",",","and","interleukin-6","by","disrupting","NF-kappa","B","signaling","in","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,0,9,10,0,0,9,0,0,9,10,0,0,7,0]}
{"id":"5456","tokens":["Truncated","c-Jun","and","c-Fos","mutant","proteins","including","wbJun","and","wbFos","were","also","ubiquitinylated","under","the","same","conditions",",","suggesting","the","sites","of","ubiquitinylation","are","located","within","the","dimerization","and","DNA","binding","domains","of","c-Jun","and","c-Fos","."],"ner_tags":[9,10,10,10,10,10,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,9,0,9,0]}
{"id":"3845","tokens":["Treatment","of","the","more","immature","B-cell","line",",","Ramos",",","with","phorbol","esters","rescues","the","cells","from","calcium-dependent","apoptosis","."],"ner_tags":[0,0,0,0,5,6,6,0,5,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6500","tokens":["The","HSFE","induced","an","area","of","enhanced","DNase","1","hypersensitivity","extending","from","the","transcriptional","start","site","to","-300bp","of","the","artificial","promoter","and","significantly","increased","the","proportion","of","beta-globin","promoters","in","an","open","chromatin","configuration","."],"ner_tags":[0,1,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,1,2,0,0,0,0,0,0]}
{"id":"11970","tokens":["New","World","primates","such","as","the","squirrel","monkey","have","elevated","cortisol","levels","and","glucocorticoid","resistance","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17396","tokens":["Two","distinct","transcription","factors","that","bind","the","immunoglobulin","enhancer","microE5\/kappa","2","motif","."],"ner_tags":[0,0,9,10,0,0,0,1,2,1,2,2,0]}
{"id":"16980","tokens":["But","the","logarithmic","mean","of","ER","content","in","lymphocytes",",","expressed","by","fmol\/mg","of","cytosolic","protein",",","in","14","patients","with","active","SLE","(","0.9356","+\/-","0.31",")","was","significantly","higher","than","that","in","13","patients","with","inactive","SLE","(","0.2979","+\/-","0.23",",","P","less","than","0.001",")","and","in","the","controls","(","0.6204","+\/-","0.52",",","P","less","than","0.001",")","."],"ner_tags":[0,0,0,0,0,9,0,0,7,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14285","tokens":["ACH-2",",","derived","from","a","human","T","cell","line","(","CEM",")",",","is","chronically","infected","with","HIV-1",",","with","low","levels","of","constitutive","virus","expression","."],"ner_tags":[5,0,0,0,0,5,6,6,6,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18502","tokens":["Transient","stimulation","of","quiescent","B","lymphocytes","with","either","a","cocktail","of","anti-CD40",",","anti-IgM",",","and","IL4",",","or","EBV","results","in","the","rapid","expression","of","the","same","four","genes",",","suggesting","that",",","after","infection",",","EBV","exploits","the","normal","program","of","B-lymphocyte","cell","cycle","activation","."],"ner_tags":[0,0,0,7,8,8,0,0,0,0,0,9,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0]}
{"id":"14650","tokens":["1",",","25-Dihydroxy","vitamin","D3","and","12-O-tetradecanoyl","phorbol-13-acetate","synergistically","induce","monocytic","cell","differentiation",":","FOS","and","RB","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,9,0,9,0,0]}
{"id":"15116","tokens":["In","the","present","paper",",","the","binding","of","a","[","125I","]","-labeled","aldosterone","derivative","to","plasma","membrane","rich","fractions","of","HML","was","studied","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0]}
{"id":"5925","tokens":["Permanently","arresting","this","ongoing","immune","response","with","either","pharmaceutical","agents","or","immunotherapy","is","a","major","challenge","for","immunology","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2730","tokens":["The","effects","of","Ara-C","on","JNK","activity","may","be","mediated","through","secondary","response","pathways","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"3101","tokens":["The","negative","effects","of","point","mutations","in","the","LMP1","(","1-231",")","core","TRAF","binding","motif","on","TRAF","binding","and","NF-kappaB","activation","genetically","link","the","TRAFs","to","LMP1","(","1-231",")","-mediated","NF-kappaB","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,9,0,0,0,0,9,0,9,0,0,0,0,9,0,0]}
{"id":"12995","tokens":["Recent","reports","have","demonstrated","that","differential","expression","of","cell","surface","molecules",",","such","as","adhesion","molecule","and","chemokine","receptor",",","is","involved","in","their","recruitment","into","target","tissues","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"17743","tokens":["In","addition",",","SE","can","induce","an","interleukin-2","(","IL-2",")","nonresponsive","state","and","apoptosis","."],"ner_tags":[0,0,0,9,0,0,0,9,0,9,0,0,0,0,0,0]}
{"id":"17565","tokens":["Instead","of","NF","kappa","B",",","the","activator","protein","3","binds","to","the","divergent","site","in","HIV-2","."],"ner_tags":[0,0,9,10,10,0,0,9,10,10,0,0,0,0,0,0,0,0]}
{"id":"3744","tokens":["Interleukin-6","promotes","multiple","myeloma","cell","growth","via","phosphorylation","of","retinoblastoma","protein","."],"ner_tags":[9,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"7906","tokens":["Electrophoretic","mobility","shift","assays","demonstrated","that","PGG-Glucan","induced","the","activation","of","an","NF-kappaB-like","nuclear","transcription","factor","in","purified","human","neutrophils","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,7,8,8,0]}
{"id":"4681","tokens":["HLA-DQB1","codon","57","is","critical","for","peptide","binding","and","recognition","."],"ner_tags":[1,2,2,0,0,0,0,0,0,0,0]}
{"id":"14111","tokens":["The","identification","of","carriers","is","of","substantial","clinical","importance","for","genetic","counseling","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12006","tokens":["This","protein","was","named","elf-2","because","its","DNA-binding","domain","is","virtually","identical","to","that","of","ets","family","member","elf-1","."],"ner_tags":[0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,9,10,10,9,0]}
{"id":"1305","tokens":["TNF-alpha",",","therefore",",","emerges","as","the","main","factor","responsible","for","a","second","phase","of","NF-kappa","B","regulation",",","controlling","both","translocation","of","p65","and","c-rel",",","and","new","mRNA","synthesis","for","c-rel","and","p105\/p50","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,0,9,0,0,0,3,0,0,9,0,9,0]}
{"id":"6665","tokens":["Binding","of","YY1","and","Oct1","to","a","novel","element","that","downregulates","expression","of","IL-5","in","human","T","cells","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,0,0,0,9,0,0,7,8,0]}
{"id":"16816","tokens":["We","have","examined","the","binding","of","nuclear","proteins","and","recombinant","thyroid","hormone","receptors","(","TRs",")","to","the","palindromic","thyroid","hormone","responsive","element","AGGTCATGACCT","(","TREp",")","using","a","gel","electrophoretic","mobility","shift","assay","."],"ner_tags":[0,0,0,0,0,0,9,10,0,9,10,10,10,0,9,0,0,0,1,2,2,2,2,0,0,1,0,0,0,0,0,0,0,0,0]}
{"id":"1062","tokens":["It","is","now","demonstrated","that","HIV-1","proviral","latency","in","the","monocytic","cell","line","U1",",","in","which","only","extremely","low","levels","of","HIV-1","expression","are","detected","in","the","baseline","unstimulated","state",",","is","associated","with","alterations","in","nuclear","factor-kappa","B","(","NF-kappa","B",")","moieties","demonstrated","in","these","cells","by","electrophoretic","mobility","shift","assays","(","EMSAs",")","and","in","situ","UV","cross-linking","studies","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4427","tokens":["Thus",",","p21ras","regulation","of","NFAT","in","T","cells","requires","the","activity","of","multiple","effector","pathways","including","those","regulated","by","MAPKK-1","\/ERK-2","and","Rac-1","."],"ner_tags":[0,0,9,0,0,9,0,7,8,0,0,0,0,0,0,0,0,0,0,0,9,9,0,9,0]}
{"id":"12130","tokens":["Interestingly",",","a","correlation","was","observed","between","monoamine","oxidase","B","enzyme","activity","in","blood","cells","(","platelets",")","and","the","binding","pattern","of","two","uncharacterized","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,0,7,8,0,7,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"3418","tokens":["In","this","study",",","EBV","gene","expression","was","determined","in","23","cases","of","nasal","lymphoma","(","NL",")","by","in","situ","hybridisation","(","ISH",")",",","reverse","transcriptase","-polymerase","chain","reaction","(","RT-PCR",")","and","immunohistochemistry","(","IH",")","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3911","tokens":["In","this","study",",","we","characterize","an","essential","upstream","IL-2","response","element","that","contains","both","consensus","and","non-consensus","GAS","motifs",",","two","putative","Ets","binding","sites","(","EBS",")",",","one","of","which","overlaps","the","consensus","GAS","motif",",","and","a","GATA","motif",",","which","overlaps","the","non-consensus","GAS","motif","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,1,2,2,2,2,0,0,0,1,2,2,0,1,0,0,0,0,0,0,0,1,2,2,0,0,0,1,2,0,0,0,0,1,2,2,0]}
{"id":"13615","tokens":["Elucidation","of","the","mechanism","involved","in","this","inhibition","of","IgE","production","shows","that","epsilon","germline","transcription","is","decreased","by","RA",",","whereas","production","of","interferon-gamma","(","IFN-gamma",")","was","not","enhanced","in","the","presence","of","RA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,1,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"1501","tokens":["Mutagenesis","studies",",","and","the","use","of","a","reporter","construct","containing","an","enhancerless","promoter",",","indicate","that","these","transcriptional","effects","are","due","principally","to","the","22-bp","sequence","duplication","and","the","NF","kappa","B","site","contained","within","it","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,2,0,0,0,0]}
{"id":"14854","tokens":["Analysis","of","intracellular","Ca2+","mobilization","suggested","that","the","CD3","\/","TcR","-dependent","signal","transduction","was","impaired","in","PMA\/Bt2cAMP-treated","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,5,6,0]}
{"id":"16577","tokens":["It","wat","found","that","the","contents","of","leucocytic","ER","in","climacteric","syndrome","patients","were","significantly","lower","than","normal","child-bearing-age","women","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16216","tokens":["The","PMA","induction","of","c-fos","mRNA","correlated","well","with","TNF","gene","induction",";","expression","of","genes","encoding","other","proteins","in","the","AP-1","complex","(","junB","and","junD",")","were","also","induced","by","PMA","."],"ner_tags":[0,0,0,0,3,4,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"5466","tokens":["mBob1","is","B-cell","restricted",",","and","is","found","in","all","B-cell","lines","representing","different","stages","of","B-cell","differentiation","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0]}
{"id":"3204","tokens":["PRRII","is","a","T-cell-specific","enhancer",",","located","between","nucleotides","-137","and","-64",",","which","binds","the","T-cell-specific","Ets","protein","Elf-1","and","HMG-I","(","Y",")","proteins","."],"ner_tags":[1,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,9,10,10,9,0,9,10,10,10,10,0]}
{"id":"8145","tokens":["Furthermore",",","CoCl2","also","caused","time-dependent","tyrosine","phosphorylation","of","mitogen-activated","protein","(","MAP",")","kinase","isoform","ERK2","without","significantly","affecting","ERK1",",","indicating","ERK2","is","the","preferred","substrate","for","upstream","kinase","of","the","MAPK","pathway","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,9,0,0,0,9,0,0,9,0,0,0,0,0,9,10,0,0,9,0,0]}
{"id":"12741","tokens":["eGLs","from","non-pregnant","endometrium","and","early","pregnancy","showed","a","variable","proliferative","response","to","5","and","100","U\/ml","interleukin-2","over","48-h","and","120-h","time","courses","."],"ner_tags":[7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"17160","tokens":["A","case","of","hypersensitivity","to","thyroid","hormones","with","normally","functioning","thyroid","gland","and","increased","nuclear","triiodothyronine","receptors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"4277","tokens":["In","contrast",",","a","cysteine","protease","inhibitor","that","also","blocks","apoptosis","had","no","substantial","affect","upon","cytokine","production","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"4351","tokens":["Pb-induced","activation","of","NF-kappa","B","is","blocked","by","antibodies","for","p65","and","p50","subunits","but","not","cRel",",","indicating","that","the","p65",":","p50","heterodimer","(","NF-kappa","B",")","is","involved","."],"ner_tags":[0,0,0,9,10,0,0,0,9,0,9,0,9,0,0,0,9,0,0,0,0,9,10,10,10,0,9,10,0,0,0,0]}
{"id":"5931","tokens":["The","requirement","for","TNF","is","further","confirmed","by","the","observation","that","the","inability","of","the","intermediate","CD4","(","+",")","CD8","(","-",")","CD3","(","-",")","thymocytes","to","replicate","the","virus","is","associated","with","a","defect","in","TNF","production","during","their","interaction","with","TEC","and","correlates","with","the","absence","of","nuclear","NF-kappaB","activity","in","these","freshly","isolated","thymocytes","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,8,8,8,8,8,8,8,8,8,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,0,0,0,0,0,0,0,9,0,0,0,7,8,8,0]}
{"id":"5807","tokens":["PKC-zeta","belongs","to","this","family","and","is","known","to","be","an","important","step","in","NF-kappa","B","activation","in","other","cell","systems","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"13673","tokens":["One","purpose","of","this","study","was","to","describe","the","profile","of","transcription","factor","activation","in","these","different","populations",",","and","assess","whether","the","patterns","observed","correlated","with","functional","differences","in","these","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3340","tokens":["Gel","shift","mobility","assay","showed","stimulation","of","the","AP-1","and","NF-kappaB","contents","in","P-LPS-treated","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"5142","tokens":["In","this","report",",","we","provide","evidence","that","in","addition","to","acting","on","IkappaBalpha",",","Tax","stimulates","the","turnover","Of","IkappaBbeta","via","a","related","targeting","mechanism","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"2186","tokens":["One","gene","product",",","when","overexpressed","in","Jurkat","T","cells",",","specifically","induced","transcription","from","the","interleukin-2","enhancer",",","by","activating","the","T-cell-specific","transcription","factors","NF-AT","and","NF-IL2A","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,1,2,0,0,0,0,9,10,10,9,0,9,0]}
{"id":"5375","tokens":["These","alterations","of","transcription","factors","are","likely","to","be","responsible","for","repression","of","IL-2","in","anergic","T","cells","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,7,8,8,0]}
{"id":"7071","tokens":["Exposure","to","NSAIDs","had","a","complex","effect","on","HSP","gene","expression","and","while","sulindac","activated","the","stress","responsive","HSP70B","promoter",",","sodium","salicylate","did","not","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0]}
{"id":"1515","tokens":["Furthermore",",","when","inducing","differentiation","in","Mono","Mac","6","cells",",","with","vitamin","D3",",","no","change","in","constitutive","or","inducible","NF-kappa","B","can","be","detected","."],"ner_tags":[0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"2156","tokens":["Peroxisome","proliferator-activated","receptor","."],"ner_tags":[9,10,10,0]}
{"id":"14306","tokens":["We","show","that","a","cellular","reducing","catalyst","thioredoxin","(","Trx",")","plays","a","major","role","in","activation","of","the","DNA","binding","of","NF","kappa","B","in","vitro","and","stimulation","of","transcription","from","the","NF","kappa","B","-dependent","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0]}
{"id":"10846","tokens":["It","was","possible","that","one","of","the","clone","13","CIITA","alleles","bore","a","mutation","that","allowed","HLA-DQ",",","but","not","HLA-DR","or","-DP","transcription","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,1,0,0,0,0,0,0,0,0]}
{"id":"6627","tokens":["The","Epstein-Barr","virus","oncoprotein","latent","membrane","protein","1","engages","the","tumor","necrosis","factor","receptor-associated","proteins","TRADD","and","receptor-interacting","protein","(","RIP",")","but","does","not","induce","apoptosis","or","require","RIP","for","NF-kappaB","activation","."],"ner_tags":[0,9,10,10,10,10,10,10,0,0,9,10,10,10,10,9,0,9,10,0,9,0,0,0,0,0,0,0,0,9,0,9,0,0]}
{"id":"148","tokens":["The","CD4","promoter","plays","an","important","role","in","the","developmental","control","of","CD4","transcription","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"12684","tokens":["The","mRNA","levels","for","fkhrl1","is","elevated","in","T","helper-induced","lymphocytes","in","comparison","to","PHA-stimulated","T","lymphocytes","."],"ner_tags":[0,0,0,0,1,0,0,0,7,8,8,0,0,0,5,6,6,0]}
{"id":"16471","tokens":["[","Regulatory","effect","of","insulin","on","glucocorticoid","receptor","in","human","peripheral","leukocytes","]"],"ner_tags":[0,0,0,0,9,0,9,10,0,7,8,8,0]}
{"id":"6889","tokens":["Moreover",",","we","further","investigated","the","physiologic","relevance","of","these","observations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17513","tokens":["(","v",")","An","EBNA-2-responsive","element","was","found","within","the","-512","to","+40","LMP1","DNA","since","this","DNA","linked","to","a","chloramphenicol","acetyltransferase","reporter","gene","was","transactivated","by","cotransfection","with","an","EBNA-2","expression","vector","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,1,2,2,0]}
{"id":"9605","tokens":["We","measured","plasma","hormones","by","radioimmunoassay","."],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"2835","tokens":["Treatment","with","soluble",",","bivalent","mAb","J393","killed","25-50","%","of","the","cell","population",",","while","concomitant","engagement","of","either","the","CD3.TcR","complex","or","the","integrins","CD18","and","CD29","significantly","potentiated","this","effect","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,5,6,0,0,0,0,0,0,0,9,10,0,0,9,9,0,9,0,0,0,0,0]}
{"id":"17155","tokens":["Viral","gene","expression","was","assayed","by","the","level","of","p24","gag","protein","released","from","cultures","transfected","with","the","proviral","constructs","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"6216","tokens":["T","cell","receptor","(","TCR",")","cross-linking","is","in","part","required","for","activation","of","NF-kappaB",",","which","is","dependent","on","the","phosphorylation","and","degradation","of","IkappaBalpha","."],"ner_tags":[9,10,10,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"6444","tokens":["These","results","reveal","a","conserved","signaling","pathway","for","TLR2","and","IL-1Rs","and","suggest","a","molecular","mechanism","for","the","inhibition","of","TLR2","by","DN","variants","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"10727","tokens":["Granulocyte-macrophage","colony-stimulating","factor","(","GM-CSF",")","regulates","differentiation",",","survival",",","and","proliferation","of","colony-forming","unit-granulocyte-macrophage","progenitor","cells","."],"ner_tags":[9,10,10,0,9,0,0,0,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"13793","tokens":["In","addition",",","the","transcription","factor","Stat-3","was","tyrosine","phosphorylated","in","the","cytoplasm","and","subsequently","translocated","to","the","cell","nucleus","."],"ner_tags":[0,0,0,0,9,10,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4225","tokens":["To","determine","the","contribution","of","the","cytoplasmic","domain","of","the","IL-7","receptor","alpha","chain","(","IL-7R","alpha",")","to","activation","of","STAT","proteins",",","transfectants","of","the","murine","pro-B","cell","line","BAF3","were","made","that","express","chimeric","receptors","consisting","of","the","extracellular","domain","of","human","granulocyte","colony-stimulating","factor","receptor","(","G-CSF-R",")","and","the","transmembrane","and","intracellular","domains","of","human","IL-7R","alpha","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,9,10,10,10,0,9,10,0,0,0,0,9,10,0,0,0,0,5,6,6,6,6,0,0,0,0,9,10,0,0,0,9,10,0,9,10,10,10,10,0,9,0,0,0,9,10,10,10,0,9,10,10,0]}
{"id":"13968","tokens":["IL-13",",","a","cytokine","similar","to","IL-4",",","is","a","regulator","of","human","B","cell","and","monocyte","functions","."],"ner_tags":[9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11614","tokens":["Mutants","of","type","5","adenovirus","(","Ad5",")","with","reiterated","DNA","sequences","in","the","E1a","region","appeared","in","a","human","T-lymphocyte","cell","line",",","Molt-4",",","persistently","infected","with","H5sub304",",","a","deletion\/substitution","mutant","that","has","a","wild-type","phenotype","in","viral","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,0,0,0,5,6,6,6,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10482","tokens":["Reactive","oxygen","species","and","antioxidants","in","inflammatory","diseases","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"2939","tokens":["Transient","overexpression","of","Bcl-2","in","mouse","and","human","T","cell","blasts","did","not","block","Fas","-mediated","apoptosis",",","whereas","etoposide-","and","glucocorticoid-induced","cytotoxicity","was","potently","inhibited","."],"ner_tags":[0,0,0,9,0,0,0,0,7,8,8,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11277","tokens":["RESULTS",":","Interleukin-6","protein","and","mRNA","production","were","significantly","increased","in","cells","transfected","with","the","CMV","IE","genes","and","stimulated","with","LPS","compared","to","LPS-stimulated","control","cells","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,5,6,6,0]}
{"id":"13604","tokens":["PKC","-dependent","Fas","expression","was","also","observed","in","several","murine","and","human","tumor","cell","lines","."],"ner_tags":[9,0,9,0,0,0,0,0,0,5,6,6,6,6,6,0]}
{"id":"13062","tokens":["Simultaneous","analysis","of","close","to","600","genes","indicated","highest","increase","in","the","expression","of","certain","transcription",",","differentiation","and","proliferation","factors","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"4472","tokens":["Therefore",",","we","analyzed","the","expression",",","DNA","binding",",","and","transcriptional","activity","of","the","endogenous","RA","and","VitD3","receptors","[","retinoic","acid","receptors","(","RARs",")",",","retinoid","X","receptors","(","RXRs",")",",","and","VitD3","receptor","(","VDR",")","]","in","the","U-937","cell","line",",","in","which","RA","and","VitD3","induce","distinct","monocytic","differentiation","pathways","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,9,10,10,0,9,0,0,9,10,10,0,9,0,0,0,9,10,0,9,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4849","tokens":["CNI-1493","inhibits","monocyte\/macrophage","tumor","necrosis","factor","by","suppression","of","translation","efficiency","."],"ner_tags":[0,0,9,10,10,10,0,0,0,0,0,0]}
{"id":"1314","tokens":["A","novel","DNA","sequence","element","termed","the","J","element","involved","in","the","regulated","expression","of","class","II","major","histocompatibility","complex","genes","was","recently","described","."],"ner_tags":[0,0,1,2,2,0,0,1,2,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0]}
{"id":"13090","tokens":["Expression","of","surface","markers",",","intracytoplasmic","content","of","cytokines","cell","cycle","analysis","after","BrdU","incorporation","and","DNA","staining","with","propidium","iodide","were","studied","by","flow","cytometry","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5122","tokens":["Stimulation","of","mouse","B","cells","with","anti-IgM","or","IgD","antibodies",",","bacterial","lipopolysaccharide",",","phorbol","12-myristate","13-acetate","plus","ionomycin",",","or","CD40","ligand","led","to","a","five-fold","to","35-fold","decrease","in","BCL-6","mRNA","levels","."],"ner_tags":[0,0,7,8,8,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,3,4,0,0]}
{"id":"7362","tokens":["We","observed","that","HMDS",",","similar","to","bacterial","lipopolysaccharide","(","LPS",")",",","increases","the","expression","of","CAT","reporter","gene","suggesting","increased","activity","of","NF-kappaB","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,9,0]}
{"id":"250","tokens":["In","view","of","the","increasing","use","of","antiestrogens","in","cancer","therapy","and","prevention",",","there","is","obvious","merit","in","long-term","in","vivo","studies","to","be","conducted","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10693","tokens":["Mutation","of","the","C-site","that","prevented","AP-1","binding","to","this","site","was","sufficient","strikingly","to","reduce","inducible","promoter","activity","in","primary","CD45R0","T","cells","."],"ner_tags":[0,0,0,1,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"2871","tokens":["SCL","protein","was","detected","in","erythroid",",","megakaryocyte",",","mast","and","early","myeloid","cell","lines",",","as","well","as","in","several","lymphoid","leukemia","cell","lines","which","are","known","to","harbor","SCL","gene","rearrangements","."],"ner_tags":[9,10,0,0,0,5,6,6,6,6,6,6,6,6,6,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,1,2,2,0]}
{"id":"14341","tokens":["Both","inducible","complexes","persisted","for","at","least","3","weeks","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"14232","tokens":["YT-N17","contained","11.8","fmol\/mg","protein","of","estrogen","receptor","(","mean","of","two","independent","assays",")",",","a","value","which","was","5-10-fold","higher","than","that","of","other","hematopoietic","cell","lines","."],"ner_tags":[5,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"15443","tokens":["The","c-jun","mRNA",",","which","is","constitutively","expressed","in","human","peripheral-blood","monocytes","at","relatively","high","levels",",","was","also","slightly","augmented","by","LTB4",",","although","to","a","much","lower","extent","than","c-fos","."],"ner_tags":[0,3,4,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0]}
{"id":"6124","tokens":["Furthermore",",","we","have","demonstrated","that","both","C\/EBPbeta","and","GATA-1","can","bind","simultaneously","to","the","C\/EBP-","and","GATA-binding","sites","in","the","MBP","promoter","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,1,2,0,0,1,2,0]}
{"id":"14217","tokens":["The","human","immunodeficiency","virus","type","1","long","terminal","repeat",",","HIV-1-LTR",",","contains","binding","sites","for","several","cellular","transcription","factors","which","contribute","to","HIV-1","gene","expression","."],"ner_tags":[0,1,2,2,2,2,2,2,2,0,1,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"8224","tokens":["To","determine","whether","either","or","both","of","these","transcription","factors","are","involved","in","cell","survival","or","cell","cycle","progression","in","response","to","IL-2",",","primary","human","T","cells","responsive","to","the","growth","factor","were","analyzed","for","NF-kappa","B","and","AP-1","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13494","tokens":["NFAT","regulates","transcription","of","a","number","of","cytokine","and","other","immunoregulatory","genes","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"1585","tokens":["EBNA2","is","thus","required","not","only","for","initiation","but","also","for","maintenance","of","transformation","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11805","tokens":["ATL-16T","cells","express","mRNA","of","three","GATA-binding","proteins",",","hGATA-2",",","hGATA-3","and","hGATA-4",",","and","each","of","them","has","a","potential","to","bind","to","the","consensus","(","A\/T",")","GATA","(","G\/","A",")","motif","."],"ner_tags":[5,6,0,3,0,0,9,10,0,9,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,0]}
{"id":"13898","tokens":["Interphase","fluorescence","in","situ","hybridization","(","FISH",")","was","performed","with","2","YACs","flanking","the","CALM","region",",","a","YAC","contig","of","the","MLL","region",",","and","a","YAC","spanning","the","AF10","breakpoint","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,2,0,0,1,2,0,0,1,2,0,0,0,1,0,0,1,0,0]}
{"id":"9487","tokens":["Freshly","isolated","cells","contain","high","levels","of","G0S2","mRNA","which","rapidly","decline","."],"ner_tags":[0,0,0,0,0,0,0,3,4,0,0,0,0]}
{"id":"17619","tokens":["The","ets","proto-oncogene","family","is","a","group","of","sequence-related","genes","whose","normal","cellular","function","is","unknown","."],"ner_tags":[0,1,2,2,0,0,0,0,1,2,0,0,0,0,0,0,0]}
{"id":"4763","tokens":["In","this","regard",",","anti-inflammatory","cytokines","inhibited","LPS","plus","GM-CSF","-stimulated","HIV","expression",",","and","this","effect","closely","correlated","with","inhibition","of","IL-1","beta","release","and",",","in","particular",",","with","up-regulation","of","endogenous","IL-1ra","production","."],"ner_tags":[0,0,0,0,9,10,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3752","tokens":["Although","CD40","ligand","(","CD40L",")","triggers","a","shift","from","dephosphorylated","to","phosphorylated","pRB","and","proliferation","of","B","cells",",","the","addition","of","exogenous","IL-6","to","CD40L","-treated","B","cells","does","not","alter","either","pRB","or","proliferation",",","as","observed","in","MM","cells","."],"ner_tags":[0,9,10,0,9,0,0,0,0,0,0,0,0,9,0,0,0,7,8,0,0,0,0,0,9,0,9,0,7,8,0,0,0,0,9,0,0,0,0,0,0,5,6,0]}
{"id":"9315","tokens":["We","therefore","investigated","whether","the","activation","of","the","IL-1RI-associated","protein","kinase","could","be","a","target","for","redox","regulation","and","whether","an","altered","activity","of","the","kinase","could","influence","IL-1","-mediated","NF-kappa","B","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0,0]}
{"id":"10967","tokens":["Thus",",","GATA-3","may","play","an","important","role","in","the","balance","between","Th1","and","Th2","subsets","in","immune","responses","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,7,0,7,8,0,0,0,0]}
{"id":"11648","tokens":["T","cell","activation","and","ensuing","cellular","gene","activation","can","be","critical","for","HIV-1","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6432","tokens":["Also",",","NF-kappa","B","activity","remained","absent","in","follow-up","studies","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0]}
{"id":"4991","tokens":["The","A-myb","gene","encodes","a","transcription","factor","that","is","related","both","functionally","and","structurally","to","the","v-myb","oncogene","."],"ner_tags":[0,1,2,0,0,9,10,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"3815","tokens":["However",",","the","mechanisms","involved","in","the","activation","of","AP-1","by","antioxidants","are","largely","unknown","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"11390","tokens":["Nuclear","factor-kappa","B","(","NF-kappa","B",")","plays","a","broad","role","in","gene","regulation",",","but","it","is","not","evident","whether","NF-kappa","B","acts","as","a","messenger","system","for","germline","C","epsilon","transcription","."],"ner_tags":[9,10,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,1,0,0,0,0]}
{"id":"5978","tokens":["The","underlying","signaling","pathways","appear","to","be","different","from","those","utilized","by","TNF-alpha",",","a","better","characterized","cytokine","that","induces","the","transcription","of","immediate-early","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"3822","tokens":["However",",","the","combined","treatment","with","PDTC","and","PMA",",","two","agents","that","synergize","on","AP-1","activation",",","resulted","in","the","persistent","phosphorylation","of","ERK-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0]}
{"id":"4045","tokens":["Similarly",",","CTL","raised","against","the","parent","peptide","did","not","recognize","the","succinimide","derivative","of","this","peptide","."],"ner_tags":[0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3141","tokens":["Their","corresponding","plasma","cortisol","levels","were","assessed","."],"ner_tags":[0,0,0,0,0,0,0,0]}
{"id":"4530","tokens":["In","studies","initiated","to","evaluate","relationships","between","EBV","latent","genes","and","p53",",","p53","levels","were","found","to","increase","approximately","10-fold","4","to","5","days","after","EBV","infection","of","purified","resting","human","B","cells",";","the","induced","p53","was","transcriptionally","active","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,9,0,0,0,0]}
{"id":"12414","tokens":["Transfection","of","a","reporter","construct","containing","the","-148","to","+60","region","of","the","human","granzyme","B","promoter","demonstrated","that","this","region","was","the","target","for","dexamethasone","repression","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4997","tokens":["A-myb","was","undetectable","in","4","prolymphocytic","leukemias","(","PLL",")","but","was","strongly","expressed","in","5\/20","(","25","%",")","of","chronic","lymphocytic","leukemia","(","CLL",")","samples","."],"ner_tags":[1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15166","tokens":["Possible","relationship","between","the","changes","in","IL-1","and","GR","in","aged","long-distance","runner","and","its","physiological","significance","are","discussed","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10989","tokens":["The","transcription","factor","NF-kappa","B","controls","the","induction","of","numerous","cytokine","promoters","during","the","activation","of","T","lymphocytes","."],"ner_tags":[0,9,10,9,10,0,0,0,0,0,1,2,0,0,0,0,7,8,0]}
{"id":"1332","tokens":["By","fusing","lymphoblastoid","cells","of","an","AGS","patient","that","exhibited","a","microdeletion","in","the","short","arm","of","Chr","20","encompassing","bands","p11.23","to","p12.3","with","rodent","thermosensitive","mutant","cells","(","CHOtsH1-1",")","deficient","in-leucyl-tRNA","synthetase",",","we","isolated","a","somatic","cell","hybrid","segregating","the","deleted","human","Chr","20","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,1,2,2,0,5,6,6,6,0,5,0,0,9,10,0,0,0,0,5,6,6,0,0,0,0,1,2,0]}
{"id":"17285","tokens":["The","DNA","isolated","contained","an","open","reading","frame","encoding","108","amino","acid","residues","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14563","tokens":["By","comparison",",","there","was","no","modification","of","the","expression","of","CD4","antigen",",","which","is","expressed","at","high","levels","in","these","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9643","tokens":["Monochloramine","inhibits","phorbol","ester-inducible","neutrophil","respiratory","burst","activation","and","T","cell","interleukin-2","receptor","expression","by","inhibiting","inducible","protein","kinase","C","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,10,0,0]}
{"id":"6710","tokens":["Defining","therapeutic","targets","by","using","adenovirus",":","blocking","NF-kappaB","inhibits","both","inflammatory","and","destructive","mechanisms","in","rheumatoid","synovium","but","spares","anti-inflammatory","mediators","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"15428","tokens":["An","11-base-pair","DNA","sequence","motif","apparently","unique","to","the","human","interleukin","4","gene","confers","responsiveness","to","T-cell","activation","signals","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0]}
{"id":"13961","tokens":["These","affected","animals","displayed","marked","splenomegaly",",","anemia",",","and","thrombocytopenia","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16260","tokens":["Constitutive","expression","of","1",",","25","(","OH",")","2D3","receptor","RNA","was","detected","in","various","kinds","of","hematopoietic","cells",",","including","macrophages","and","activated","T","lymphocytes",",","as","well","as","in","cell","lines","KG-1","(","myeloblasts",")",",","HL-60","(","promyelocytes",")",",","ML-3","(","myelomonoblasts",")",",","U937",",","THP-1","(","monoblasts",")",",","K562","(","erythroblasts",")",",","and","S-LB1","(","HTLV-1-transfected","T","lymphocytes",")","."],"ner_tags":[0,0,0,3,4,4,4,4,4,4,4,4,0,0,0,0,0,0,7,8,0,0,0,0,0,7,8,0,0,0,0,0,0,0,5,0,5,0,0,5,0,5,0,0,5,0,5,0,0,5,0,5,0,5,0,0,5,0,5,0,0,0,5,0,5,6,6,0,0]}
{"id":"9503","tokens":["Further",",","we","have","found","that","these","factors","cooperate","in","the","repression","of","LTR","expression","and","viral","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0]}
{"id":"5670","tokens":["Mutations","of","this","site","that","destroyed","potential","ets","transcription","factor","binding","sites","had","reduced","transcriptional","activity","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0]}
{"id":"10674","tokens":["Ionomycin","induced","synergistic","activation","of","NFAT","in","cells","expressing","p85","mutants","that","contained","the","C-terminal","SH2","domain","."],"ner_tags":[0,0,0,0,0,9,0,0,0,9,10,0,0,0,9,10,10,0]}
{"id":"1481","tokens":["Ten-day","exposure","to","Epo","induced","mature","erythroblasts","and","red","cells","."],"ner_tags":[0,0,0,9,0,7,8,0,7,8,0]}
{"id":"9160","tokens":["Furthermore",",","we","investigated","the","effects","of","C3a","and","C3a","(","desArg",")","on","induction","of","NF-kappaB","and","activating","protein-1","binding","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,10,10,10,0,0,0,9,0,9,10,0,0]}
{"id":"52","tokens":["This","segment","functions","as","an","IL-2-inducible","enhancer","and","lies","within","a","region","that","becomes","DNase","I","hypersensitive","in","normal","T","cells","in","which","IL-2R","alpha","expression","has","been","induced","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,0,9,10,0,0,0,7,8,0,0,9,10,0,0,0,0,0]}
{"id":"18124","tokens":["Patients","with","overt","hypo","-or","hyperthyroidism","were","enrolled","in","the","study","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16814","tokens":["Thus",",","in","lymphocytes",",","growth-affecting","genes","other","than","immune","receptors","risk","rearrangements","."],"ner_tags":[0,0,0,7,0,1,2,0,0,9,10,0,0,0]}
{"id":"15427","tokens":["We","conclude","that","stimulation","with","mitogenic","lectins","is","sufficient","to","increase","both","c-Fos","and","c-Jun","protein","levels",",","AP-1","binding","and","AP-1","enhancer","activity","in","Jurkat","cells","and","that","they","act","via","mechanisms","that","could","involve","the","activation","of","PKC","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16993","tokens":["The","amino-terminal","domain","has","regions","homologous","to","the","oncogene","rel","and","to","the","developmentally","important","gene","dorsal","of","Drosophila","."],"ner_tags":[0,9,10,0,0,0,0,0,1,2,0,0,0,0,0,0,1,0,0,0]}
{"id":"14754","tokens":["HIV-1","activation","and","expression","was","quantitated","by","reverse","transcriptase","assay","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0]}
{"id":"1330","tokens":["Deleted","chromosome","20","from","a","patient","with","Alagille","syndrome","isolated","in","a","cell","hybrid","through","leucine","transport","selection",":","study","of","three","candidate","genes","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3301","tokens":["Regions","of","low","base","order-dependent","stem-loop","potential","in","the","region","of","the","gene","are","defined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16453","tokens":["ER","was","positive","in","13","and","PR","was","positive","in","12","of","the","20","samples","."],"ner_tags":[9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"1862","tokens":["The","suppressive","effect","of","liposomal","MPL","in","comparison","with","free","drug","was","significantly","prolonged","(",">","120","h","vs","<","18","h",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7485","tokens":["High","retinoidal","activity","(","agonist","or","antagonist","for","retinoic","acid","receptor","(","RAR",")","requires","a","carboxylic","acid","moiety","and","an","appropriate","hydrophobic","group","located","at","a","suitable","position","on","the","molecule","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8634","tokens":["The","upstream","regulatory","element","could","confer","T-cell","specificity","to","the","GATA-3","promoter","activity",",","and","analysis","of","this","region","revealed","a","707-base","pair","silencer","that","drastically","inhibited","GATA-3","promoter","activity","in","non-T-cells","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,1,2,0,0,7,0]}
{"id":"385","tokens":["LFA-3","induced","moderate","levels","of","AP-1",",","but","did","not","influence","the","levels","of","NF-kappa","B",",","while","B7","costimulation","strongly","induced","both","AP-1","and","substantially","enhanced","NF-kappa","B","binding","proteins","."],"ner_tags":[9,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0,0,9,0,0,0,0,9,0,0,0,9,10,10,10,0]}
{"id":"4792","tokens":["In","vitro",",","chronically","HIV-infected","cells","of","the","lymphoid","CEM","line","displayed","resistance","to","glucocorticoid-induced","apoptosis","."],"ner_tags":[0,0,0,5,6,6,0,0,5,6,6,0,0,0,0,0,0]}
{"id":"1487","tokens":["The","T","cell","surface","molecule","CD28","binds","to","ligands","on","accessory","cells","and","APCs",",","playing","an","important","costimulatory","role","in","the","response","of","T","cells","to","Ags","."],"ner_tags":[0,9,10,10,10,9,0,0,0,0,7,8,0,7,0,0,0,0,0,0,0,0,0,0,7,8,0,9,0]}
{"id":"10351","tokens":["They","are","rapidly","activated","by","various","cytokines",",","hormones",",","and","growth","factors","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"15920","tokens":["Glucocorticoids","are","known","to","downregulate","interleukin-1","beta","production","in","monocytic","cells","by","two","different","mechanims",":","direct","inhibition","of","the","gene","transcription","and","destabilization","of","the","preformed","interleukin-1","beta","mRNA","."],"ner_tags":[0,0,0,0,0,9,10,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,4,0]}
{"id":"2004","tokens":["Deletion","of","all","three","elements","abolished","inducibility","of","IL-6","promoter","activity","by","both","LAM","and","LPS","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,9,0,0,0]}
{"id":"7911","tokens":["Phagocyte","recognition",",","uptake",",","and","nonphlogistic","degradation","of","neutrophils","and","other","leukocytes","undergoing","apoptosis","promote","the","resolution","of","inflammation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,0,0,7,0,0,0,0,0,0,0,0]}
{"id":"16171","tokens":["In","fact",",","IFNs","inhibit","growth","of","various","normal","and","transformed","cell","types","."],"ner_tags":[0,0,0,9,0,0,0,0,7,0,7,8,8,0]}
{"id":"11164","tokens":["By","contrast",",","phosphatidic","acid","accumulation",",","pleckstrin","phosphorylation",",","and","calcium","mobilization","produced","by","the","combination","of","NE","and","threshold","of","cathepsin","G","were","not","significantly","different","from","those","measured","with","threshold","of","cathepsin","G","alone","(","p",">","0.05",")",",","indicating","that","the","phospholipase","C","\/protein","kinase","C","pathway","is","not","involved","in","the","potentiation","of","aggregation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,9,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"8522","tokens":["Whereas","CD36","and","mEI","were","expressed","in","all","hematopoetic","cell","lines","containing","Oct2",",","."],"ner_tags":[0,9,0,9,0,0,0,0,5,6,6,0,9,0,0]}
{"id":"5568","tokens":["The","decrease","using","weaker","binding","peptides","was","gradual","as","stimulation","with","a","peptide","with","intermediate","affinity","yielded","intermediate","T","cell","proliferation","and","the","poorest","binding","peptide","induced","an","even","weaker","T","cell","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,7,8,0,0]}
{"id":"9313","tokens":["The","initiating","event","is","still","uncertain",",","but","activation","of","a","recently","described","receptor-associated","protein","kinase","is","one","of","the","earliest","events","detectable","(","Martin","et","al.",",","Eur.J.Immunol.1994.24",":","1566",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9950","tokens":["Although","IL-4","activated","signal","transducers","and","activators","of","transcription","(","STAT",")","6","in","addition","to","NF-kappaB",",","NAC","treatment","or","the","transfection","of","decoy","oligodeoxynucleotides","for","NF-kappaB","or","STAT6","only","partly","blocked","IL-4","-induced","germline","Cepsilon","transcription","."],"ner_tags":[0,9,0,9,10,10,10,10,10,10,10,10,10,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,9,0,1,0,0,0]}
{"id":"17609","tokens":["The","56-59-kilodalton","protein","identified","in","untransformed","steroid","receptor","complexes","is","a","unique","protein","that","exists","in","cytosol","in","a","complex","with","both","the","70-","and","90-kilodalton","heat","shock","proteins","."],"ner_tags":[0,9,10,0,0,9,10,10,10,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"8392","tokens":["In","this","study",",","we","cloned","two","cDNAs","encoding","proteins","which","bind","to","an","oligonucleotide","in","silencer","I","containing","a","BP1","binding","site","."],"ner_tags":[0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,2,0,0,9,0,0,0]}
{"id":"8786","tokens":["Concerning","tumor-infiltrating","lymphocytes",",","the","rate","of","moderate","or","remarkable","grades","of","c-fos-positive","lymphocytes","before","radiotherapy","and","at","radiation","doses","of","4",",","10",",","and","20","Gy","was","8.0",",","29.2",",","4.8",",","and","0","%",",","respectively","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2322","tokens":["Mechanisms","involved","in","the","inhibition","of","growth","of","a","human","B","lymphoma","cell","line",",","B104",",","by","anti-MHC","class","II","antibodies","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,6,6,6,0,5,0,0,9,10,10,10,0]}
{"id":"6552","tokens":["Although","erythroid","progenitors","appear","to","be","the","principal","EPO-responsive","cell","type","in","vivo","due","to","the","restricted","expression","of","the","EPOR",",","many","growth","factor-dependent","cell","lines","expressing","the","EPOR","can","respond","to","EPO","by","activating","many","or","all","of","these","pathways","."],"ner_tags":[0,7,8,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,9,0,0,5,6,6,6,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"192","tokens":["In","erythroid","cells","most","of","the","transcription","activity","was","contained","in","a","150","bp","promoter","fragment","with","binding","sites","for","transcription","factors","AP2",",","Sp1","and","the","erythroid-specific","GATA-1","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,0,9,10,9,0,9,0,0,9,10,0]}
{"id":"865","tokens":["A","DNA","response","element","(","TR2RE-SV40",")","for","the","TR2","orphan","receptor",",","a","member","of","the","steroid-thyroid","hormone","receptor","superfamily",",","has","been","identified","in","the","simian","virus","40","(","SV40",")","+55","region","(","nucleotide","numbers","368-389",",","5'-GTTAAGGTTCGTAGGTCATGGA-3","'",")","."],"ner_tags":[0,1,2,2,0,1,0,0,0,9,10,10,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,1,2,2,0,0,0,0,0]}
{"id":"6762","tokens":["OBJECTIVE",":","We","investigated","the","effect","of","DEP-PAHs","on","the","release","and","mRNA","expression","of","IL-8",",","MCP-1",",","and","RANTES","by","PBMCs","obtained","from","healthy","subjects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,3,0,0,9,0,9,0,0,9,0,7,0,0,0,0,0]}
{"id":"3183","tokens":["However",",","it","was","still","lower","than","that","in","healthy","subjects","(","P","<","0.01",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2648","tokens":["A","comparison","with","known","proteins","in","Genbank","revealed","that","all","three","S6","peptides","match","the","predicted","sequence","of","TBP7",",","Tat-binding","protein","7","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,10,10,0]}
{"id":"10613","tokens":["Both","signal","cascades","contribute","to","the","induction","of","the","interleukin","2","(","IL-2",")","gene","during","T-cell","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0]}
{"id":"6999","tokens":["In","some","patients",",","no","activation","of","RelA\/NFkappaB1","-binding","activity","was","detectable",",","while","in","others","kappaB","-binding","activity","was","modestly","induced","but","the","duration","was","reduced","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17814","tokens":["Circadian","rhythm","of","glucocorticoid","receptors","in","human","peripheral","leukocytes","and","their","reactivity","to","glucocorticoids","."],"ner_tags":[0,0,0,9,10,0,7,8,8,0,0,0,0,0,0]}
{"id":"17426","tokens":["In","lymphocytes",",","the","octamer-binding","protein","Oct-2A","and","variants","thereof","are","thought","to","contribute","to","the","B-cell","specific","gene","expression",",","while","the","ubiquitous","protein","Oct-1","seems","to","control","general","octamer","site","-dependent","transcription","."],"ner_tags":[0,7,0,0,9,10,9,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0]}
{"id":"3248","tokens":["Interferon","alpha","selectively","affects","expression","of","the","human","myeloid","cell","nuclear","differentiation","antigen","in","late","stage","cells","in","the","monocytic","but","not","the","granulocytic","lineage","."],"ner_tags":[9,10,0,0,0,0,0,9,10,10,10,10,10,0,7,8,8,0,0,7,0,0,0,7,8,0]}
{"id":"10328","tokens":["Thus",",","C.","neoformans","and","C.","albicans","enhance","HIV","expression","in","monocytic","cells","through","a","TNF-alpha-","and","NF-kappaB-dependent","mechanism","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"1356","tokens":["A","missense","mutation","in","the","region","coding","for","the","cytoplasmic","portion","of","the","gamma","c","gene","was","found","in","three","affected","males","but","not","in","a","normal","brother","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1231","tokens":["In","this","study",",","we","demonstrate","that","Tax","-stimulated","nuclear","expression","of","NF-kappa","B","in","both","HTLV-I-infected","and","Tax-transfected","human","T","cells","is","associated","with","the","phosphorylation","and","rapid","proteolytic","degradation","of","I","kappa","B","alpha","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,9,10,0,0,5,6,6,6,6,6,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"9576","tokens":["In","monocytic","THP-1","cells","TNF-alpha","induced","two","nuclear","complexes","which","in","vitro","bound","to","the","ICAM-1","kappa","B","site","."],"ner_tags":[0,5,6,6,9,0,0,9,10,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"6692","tokens":["HTLV-1-transformed","T-cell","lines","expressed","higher","amounts","of","STAT1",",","STAT3","and","STAT5","RNA","and","proteins","than","virus-negative","T","cells","."],"ner_tags":[5,6,6,0,0,0,0,3,4,4,4,4,4,0,0,0,7,8,8,0]}
{"id":"16305","tokens":["Consistent","with","involvement","in","the","G0\/G1","switch",",","the","protein","contains","potential","sites","for","phosphorylation","by","protein","kinase","C","and","casein","kinase","II","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,10,0]}
{"id":"14446","tokens":["We","have","identified","a","putative","transcription","factor",",","designated","PILOT",",","with","an","identical","dual","signal","requirement","for","expression","."],"ner_tags":[0,0,0,0,0,9,10,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"12563","tokens":["The","action","of","adenoviral","E1A","oncoprotein","on","host","immune-response","genes","has","been","attributed","to","interaction","with","p300\/CBP-type","transcriptional","coactivators","in","competition","with","endogenous","transcription","factors","such","as","signal","transducer","and","activator","of","transcription","(","STAT",")","proteins","."],"ner_tags":[0,0,0,9,10,10,0,1,2,2,0,0,0,0,0,0,9,10,10,0,0,0,9,10,10,0,0,9,10,10,10,10,10,10,10,10,10,0]}
{"id":"16576","tokens":["The","results","were","compared","with","those","of","12","normal","child-bearing-age","women","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3532","tokens":["The","probable","regulatory","point","was","the","cytoplasmic","IkappaB","inhibitor",":","in","CD45RA+","cells",",","H2O2","caused","a","more","profound","depression","in","the","levels","of","IkappaB","alpha","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"5718","tokens":["The","frequencies","of","CD8","(","+",")","T","cells","directed","against","IE-1","were","similar","to","those","directed","against","pp65","in","donors","tested","with","known","pp65","-derived","peptides","."],"ner_tags":[0,0,0,7,8,8,8,8,8,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,9,0,0,0]}
{"id":"5658","tokens":["The","homologous","peptide","430-444",",","442A","has","an","Asp","to","Ala","substitution","at","position","442","and","binds","to","DQ0302","with","a","Kd","similar","to","433-442","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8892","tokens":["Analysis","of","the","predicted","amino","acid","sequence","suggests","that","overall","protein","structure","is","conserved",",","but","the","receptor","binding","sites","are","not","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8887","tokens":["The","gene","encoding","a","chicken","cytokine","with","T-cell","proliferative","activity","was","cloned",",","sequenced",",","and","mapped","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6890","tokens":["When","submitted","to","an","in","vitro","CD4","cross-linking","by","iHIV-1",",","PBMCs","from","HIV-1-infected","patients","were","found","to","produce","virus","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,7,0,0,0,0,0,0,0,0,0]}
{"id":"1125","tokens":["The","expression","levels","of","human","RAR","alpha","(","hRAR","alpha",",","receptor","for","all-trans","RA",")","and","the","human","retinoid-X","receptor","alpha","(","hRXR","alpha","receptor","for","9-cis","RA",")","were","determined","by","Northern","blot","analysis","."],"ner_tags":[0,0,0,0,9,10,10,0,9,10,10,10,0,0,0,0,0,0,9,10,10,10,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9293","tokens":["Fetal","and","neonatal","lymphocytes","are","relatively","resistant","to","activation","and","cytokine","production","when","stimulated","either","via","their","T-cell","antigen","receptors","or","lectins","."],"ner_tags":[7,8,8,8,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,10,0,9,0]}
{"id":"685","tokens":["In","this","report",",","we","show","that","TAL1","is","expressed","in","the","leukemic","cells","of","most","patients","with","T-ALL",",","including","many","that","do","not","display","an","apparent","TAL1","gene","alteration","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"11025","tokens":["Consequently",",","T","lymphocytes","present","in","the","spleen","can","be","activated","normally","in","response","to","either","stimulus","mentioned","above",",","demonstrating","that","the","effects","of","the","inactive","CaMKIV","on","activation","are","reversible","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"4117","tokens":["The","recognition","of","both","the","POU","domain","and","the","octamer","sequence","by","OCA-B","provides","a","mechanism","for","differential","regulation","of","octamer","sites","containing","genes","by","the","ubiquitous","factor","Oct-1","."],"ner_tags":[0,0,0,0,0,1,2,0,0,1,2,0,9,0,0,0,0,0,0,0,1,2,0,0,0,0,9,10,9,0]}
{"id":"18048","tokens":["Cross-linking","of","Fc","gamma","receptors","activates","HIV-1","long","terminal","repeat","-driven","transcription","in","human","monocytes","."],"ner_tags":[0,0,9,10,10,0,1,2,2,2,0,0,0,7,8,0]}
{"id":"10578","tokens":["To","isolate","cDNA","clones","that","dominantly","inhibit","the","DNA-binding","activity","of","Oct-2",",","chosen","as","a","representative","factor",",","we","have","developed","a","novel","screening","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17444","tokens":["Treatment","of","an","HTLV-I","infected","human","T-cell","line","with","H-7","blocked","specifically","accumulation","of","the","unspliced","gag-pol","mRNA",",","resulting","in","the","decreased","Gag","protein","synthesis","that","corresponds","with","the","decreased","in","vivo","phosphorylation","of","Rex","."],"ner_tags":[0,0,0,5,6,6,6,6,0,0,0,0,0,0,0,3,4,4,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"10436","tokens":["We","show","that","a","constitutively","active","mutant","of","human","Toll","transfected","into","human","cell","lines","can","induce","the","activation","of","NF-kappaB","and","the","expression","of","NF-kappaB-controlled","genes","for","the","inflammatory","cytokines","IL-1",",","IL-6","and","IL-8",",","as","well","as","the","expression","of","the","co-stimulatory","molecule","B7.1",",","which","is","required","for","the","activation","of","naive","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,1,2,0,0,9,10,9,0,9,0,9,0,0,0,0,0,0,0,0,9,10,9,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"16583","tokens":["Evaluation","of","the","role","of","ligand","and","thermal","activation","of","specific","DNA","binding","by","in","vitro","synthesized","human","glucocorticoid","receptor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"13698","tokens":["Peripheral","T","lymphocytes","from","women","with","breast","cancer","exhibit","abnormal","protein","expression","of","several","signaling","molecules","."],"ner_tags":[7,8,8,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"3924","tokens":["We","previously","reported","the","purification","of","human","PTF",",","a","complex","of","four","subunits",",","and","the","molecular","cloning","and","characterization","of","PTF","gamma","and","delta","subunits","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"16478","tokens":["Lymphocytes","from","patients","who","have","received","anti-estrogen","therapy","show","similar","enhancement","of","Ig-secreting","cells","after","PWM","stimulation","."],"ner_tags":[7,0,0,0,0,0,0,0,0,0,0,0,7,8,0,9,0,0]}
{"id":"5873","tokens":["Of","note",",","both","the","phosphorylated","and","the","dephosphorylated","form","of","NFATp","bound","to","calcineurin","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0]}
{"id":"11886","tokens":["In","contrast",",","prostaglandin","I2","(","PGI2",")",",","a","strong","negative","regulator","of","platelet","function",",","inhibited","agonist-induced","as","well","as","Ca2+-induced","activation","of","Rap1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"6477","tokens":["Both","the","DNA","binding","and","transactivation","domains","of","PU.1","are","required","for","repression","and","both","domains","are","also","needed","to","block","terminal","differentiation","in","MEL","cells","."],"ner_tags":[0,0,9,10,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"4153","tokens":["To","overcome","this","problem",",","we","have","exploited","the","observation","that","activated","human","T","cell","blasts","can","be","stimulated","via","the","CD28","surface","molecule","in","the","absence","of","antigenic","challenge",";","thus",",","we","have","been","able","to","observe","the","response","of","normal","T","cells","to","CD28","activation","in","isolation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,9,0,0,0,0]}
{"id":"7327","tokens":["To","understand","the","role","of","NF-kappa","B","complexes","in","T","cell","development","and","activation",",","we","have","generated","transgenic","mice","in","which","RelA","and","c-Rel","complexes","were","selectively","inhibited","in","the","T-lineage","cells","by","specific","expression","of","a","trans-dominant","form","of","I","kappa","B","alpha","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"14184","tokens":["Glucocorticoid","receptors","in","mononuclear","cells","of","patients","with","sepsis","."],"ner_tags":[9,10,0,7,8,0,0,0,0,0]}
{"id":"2492","tokens":["We","therefore","conclude","that","Bcl-2","upregulation","is","part","of","the","panoply","of","cellular","changes","induced","by","LMP1","but","that","the","effect","is","cell","type","specific","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"6519","tokens":["In","HeLa","cells",",","the","protein","was","almost","exclusively","localized","to","the","ribosome","salt","wash","fraction","of","cell","lysates","."],"ner_tags":[0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8597","tokens":["The","lack","of","B29","transcripts",",","coding","for","the","beta","subunit","of","the","B-cell","receptor","complex",",","in","pro-B","cells","from","EBF","-deficient","mice","suggested","that","B29","might","be","a","genetic","target","for","EBF","."],"ner_tags":[0,0,0,3,4,0,0,0,0,9,10,0,0,0,0,0,0,0,7,8,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"17050","tokens":["Transcriptional","and","post-transcriptional","regulation","of","c-jun","expression","during","monocytic","differentiation","of","human","myeloid","leukemic","cells","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,0,5,6,6,6,0]}
{"id":"4024","tokens":["In","previous","studies",",","we","identified","calcineurin","mutations","that","block","binding","by","the","cyclophilin","A\/CsA","or","FKBP12\/FK506","complexes","and","thereby","render","yeast","cells","resistant","to","the","antifungal","effects","of","CsA","or","FK506","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4367","tokens":["Treatment","of","the","acute","promyelocytic","(","APL",")","cell","line","NB4","with","interferon","alpha","(","IFN","(","alpha",")",")",",","as","well","as","IFN","(","beta",")","and","gamma",",","results","in","an","increased","expression","of","the","transcripts","coding","for","retinoic-acid","receptor","type","alpha","(","RAR","(","alpha",")",")","and","the","leukemia-specific","retinoic","acid","receptor","PML-RAR","."],"ner_tags":[0,0,0,5,6,6,6,6,6,6,5,0,9,10,0,9,10,10,10,0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,10,10,10,0,0,0,9,10,10,10,9,0]}
{"id":"15032","tokens":["In","one","patient",",","transient","reduction","of","aldosterone","receptors","could","be","documented",",","while","in","the","second","patient","the","clinical","and","biochemical","parameters","were","consistent","with","transient","pseudohypoaldosteronism","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18356","tokens":["Constitutive","activation","of","different","Jak","tyrosine","kinases","in","human","T","cell","leukemia","virus","type","1","(","HTLV-1",")","tax","protein","or","virus-transformed","cells","."],"ner_tags":[0,0,0,0,9,10,10,0,9,10,10,10,10,10,10,10,10,10,10,10,0,5,6,0]}
{"id":"15339","tokens":["Most","of","the","AP-1","activity","could","be","eliminated","when","the","anti-AIM","mAb","was","added","to","the","culture","medium","in","the","presence","of","cycloheximide",",","suggesting","that","de","novo","protein","synthesis","is","crucial","for","the","induction","of","AP-1","-binding","activity","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"8940","tokens":["Interestingly",",","Nmi","lacks","an","intrinsic","transcriptional","activation","domain",";","instead",",","Nmi","enhances","the","association","of","CBP\/p300","coactivator","proteins","with","Stat1","and","Stat5",",","and","together","with","CBP\/p300","can","augment","IL-2-","and","IFNgamma-dependent","transcription","."],"ner_tags":[0,0,9,0,0,0,9,10,10,0,0,0,9,0,0,0,0,9,10,10,0,9,0,9,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"9340","tokens":["GR6","is","activated","in","the","UCSD-AML1","cell","line","and","in","a","leukemic","sample",",","both","of","which","carry","a","t","(","3",";","3",")","(","q21",";","q26",")","."],"ner_tags":[1,0,0,0,0,5,6,6,0,0,0,5,6,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0]}
{"id":"18259","tokens":["The","trapped","LDL","is","seeded","with","oxidative","species","released","by","the","overlying","endothelium",",","and","lipid","oxidation","is","initiated","within","the","LDL","particle.","Some","of","the","lipids","that","result","lead","to","the","activation","of","NFkB-like","transcription","factors","that","cause","the","expression","of","genes","whose","protein","products","mediate","monocyte","binding",",","monocyte","chemotaxis","into","the","subendothelial","space",",","and","conversion","into","macrophages","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0,0,0,0,7,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"17175","tokens":["The","c-jun","gene","expression","was","very","transient","and","was","not","detectable","by","60","min","after","M-CSF","addition","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"6019","tokens":["As","far","as","we","know",",","these","myb-transformed","hemopoi-etic","cells","(","MTHC",")","differ","from","normal","only","in","the","unregulated","expression","of","myb",",","a","gene","whose","expression","is","obligatory","for","proliferation","of","hemopoietic","cells","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12649","tokens":["Also",",","gel","mobility","shift","analyses","using","specific","antiserum","revealed","decrease","in","the","DNA-binding","activity","of","an","insulin","gene","transcription","factor",",","PDX-1\/IPF1\/STF-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0]}
{"id":"6472","tokens":["Restoration","of","terminal","differentiation","in","the","mouse","erythroleukemia","(","MEL",")","cells","requires","a","decline","in","the","level","of","PU.1",",","indicating","that","PU.1","can","block","erythroid","differentiation","."],"ner_tags":[0,0,0,0,0,0,5,6,6,6,6,6,0,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0]}
{"id":"11020","tokens":["The","presence","of","this","protein","results","in","a","markedly","reduced","thymic","cellularity",",","although","the","distribution","of","the","remaining","cells","is","normal","based","on","evaluation","of","the","CD4","and","CD8","cell","surface","antigens","that","are","used","to","gauge","T","cell","development","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,9,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"17181","tokens":["These","genes","may","then","play","a","role","in","altering","the","physiologic","status","of","the","cells","in","response","to","CSF","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"4956","tokens":["To","analyze","the","mechanisms","that","lead","to","the","expression","of","IL-1alpha","in","HTLV-I-infected","cell","lines",",","we","studied","regulatory","regions","of","the","human","IL-1alpha","promoter","involved","in","activation","of","the","IL-1alpha","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,5,6,6,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,1,2,0]}
{"id":"17135","tokens":["Recently",",","a","number","of","other","octamer","factor","variants","were","identified","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0]}
{"id":"6930","tokens":["BACKGROUND",":","Adhesion","molecule","expression","on","the","endothelial","cell","(","EC",")","surface","is","critical","for","leukocyte","recruitment","to","atherosclerotic","lesions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7695","tokens":["However",",","like","normal","Ter","119","erythroid","cells",",","these","Ter","119","positive","cells","from","transgenic","mice","still","expressed","high","levels","of","beta-globin","and","very","low","or","undetectable","glycoprotein","IIb","and","platelet","factor","4","megakaryocytic","transcripts","."],"ner_tags":[0,0,0,5,6,6,6,6,0,0,5,6,6,6,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,0,9,10,10,10,10,0]}
{"id":"8525","tokens":["The","bare","lymphocyte","syndrome","(","BLS",")","is","characterized","by","the","absence","of","MHC","class","II","transcription","and","humoral-","and","cellular-mediated","immune","responses","to","foreign","antigens","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14581","tokens":["A","protein","of","the","AP-1","family","is","a","component","of","nuclear","factor","of","activated","T","cells","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"10431","tokens":["The","mechanisms","that","control","the","initial","induction","of","these","signals","upon","infection","are","poorly","understood","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15313","tokens":["These","observations","indicate","that","during","chronic","HIV","infection","of","U937","cells",",","continuous","NF-kappa","B","(","p50\/p65",")","translocation","results","in","p105","promoter","upregulation","with","subsequent","cytosolic","NF-kappa","B","accumulation",",","ready","for","further","translocation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"15761","tokens":["Moreover",",","the","steroid","receptor","agonist","cortisol","(","10","microM",")",",","but","not","its","inactive","metabolite","tetrahydrocortisol","(","10","microM",")",",","diminished","LPS-induced","endothelial","cell","adhesiveness","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9614","tokens":["This","hypothesis","is","supported","by","evidence","of","hypertension","and","low","renin","activity",",","which","others","have","described","in","patients","with","primary","glucocorticoid","resistance","due","to","mutations","of","the","glucocorticoid","receptor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"6200","tokens":["Estrogen","receptors","influence","non-genomic","events",",","which","are","rapid","in","onset","and","genomic","events",",","which","are","longer","acting","responses","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13894","tokens":["The","translocation","t","(","10",";","11",")","(","p13",";","q14",")","has","been","observed","in","acute","lymphoblastic","leukemia","(","ALL",")","as","well","as","acute","myeloid","leukemia","(","AML",")","."],"ner_tags":[0,1,2,2,2,2,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"496","tokens":["Abnormal","regulation","of","the","IL-2","promoter","in","lpr","CD4-CD8-","T","lymphocytes","results","in","constitutive","expression","of","a","novel","nuclear","factor","of","activated","T","cells-binding","factor","."],"ner_tags":[0,0,0,0,1,2,0,0,5,6,6,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0]}
{"id":"1631","tokens":["RJ","2.2.5","is","a","human","B","cell","mutant","derived","from","the","Burkitt","lymphoma","Raji","cell","which","is","defective","in","the","AIR-1","locus","function","."],"ner_tags":[5,6,0,0,5,6,6,6,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0]}
{"id":"14197","tokens":["We","have","previously","reported","that","infection","with","herpes","simplex","virus","type","1","(","HSV-1",")","activates","expression","of","the","human","immunodeficiency","virus","type","1","(","HIV-1",")","provirus","in","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"14366","tokens":["These","results","indicate","that",",","among","HIV1","gene","products",",","the","Tat","protein","appears","to","trigger","monocytic","differentiation",",","and","suggests","that","this","viral","protein","directs","progenitors","of","the","monocyte\/macrophage","lineage","towards","a","differentiation","stage","in","which","production","of","viral","antigens","and","virions","might","be","more","efficient","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"17574","tokens":["Here",",","we","present","the","isolation","and","characterization","of","the","full-length","cDNA","clone","encoding","NF-X2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,0,9,0]}
{"id":"10202","tokens":["The","production","of","both","cytokines",",","measured","by","ELISA","tests",",","was","enhanced","in","monocytes","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"2589","tokens":["We","sought","to","determine","if","this","pathway","were","present","in","CHO\/CD14","cells","and","to","elucidate","the","relationship","of","NF-kappa","B","activation","to","the","CD14","receptor","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,9,10,0,0,0,9,0,0,0]}
{"id":"1894","tokens":["Therefore",",","the","effects","of","PGE2","vary","depending","on","the","mode","of","T","cell","activation",",","and","the","IL-4","and","IL-5","are","regulated","differently","from","other","cytokines","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,9,0]}
{"id":"5203","tokens":["Campomelic","dysplasia","(","CMPD1",")","and","autosomal","XY","sex","reversal","(","SRA1",")","are","caused","by","mutations","in","the","SRY-related","gene","SOX9","on","17q","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,1,0,1,0]}
{"id":"9337","tokens":["In","addition",",","the","combined","inhibitory","effects","on","NFAT","and","NF-KB","support","a","potential","use","of","DTCs","as","immunosuppressants","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"590","tokens":["Its","mRNA","expression","pattern","is","complex","during","embryogenesis",",","yet","restricted","to","lymphocytes","postnatally","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,0,0]}
{"id":"892","tokens":["A","truncated","Tat","protein","(","Tat1-72",")",",","known","to","transactivate","the","HIV-1","long","terminal","repeat","(","LTR",")",",","no","longer","affected","Mn-SOD","expression",",","the","cellular","redox","state","or","TNF","-mediated","cytotoxicity","."],"ner_tags":[0,0,9,10,0,9,0,0,0,0,0,0,1,2,2,2,0,1,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"2297","tokens":["These","results","demonstrate","that","there","are","detectable","Ad","2\/5","E1a","sequences","in","the","respiratory","epithelium","of","a","small","percentage","of","normals","and","individuals","with","CF","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15093","tokens":["Plasma","18-hydroxycorticosterone","was","also","significantly","(","P","less","than","0.025",")","lower","(","PIH",",","1071","+\/-","149","pmol\/L",";","controls",",","1907","+\/-","318","pmol\/L",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9518","tokens":["In","particular",",","the","part","played","by","the","retinoid","X","receptors","(","RXRs",")",",","which","are","members","of","the","steroid\/thyroid","hormone","nuclear","receptor","family",",","has","not","been","explored","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0]}
{"id":"7166","tokens":["Protein","expression","was","assessed","by","western","blot","analysis","or","immunofluorescence","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2356","tokens":["Mutation","of","the","major","Sp1","binding","site","(","-110","bp",")","decreased","tissue-specific","promoter","activity",",","and","these","results",",","together","with","transactivation","experiments",",","demonstrate","that","Sp1","plays","a","critical","role","in","the","tissue-specific","expression","of","CD14","in","monocytic","cells","."],"ner_tags":[0,0,0,1,2,2,2,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,7,8,0]}
{"id":"14367","tokens":["Analysis","of","the","preexisting","and","nuclear","forms","of","nuclear","factor","of","activated","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"5054","tokens":["When","fused","to","GAD",",","the","C-terminal","region","of","Ku","was","able","to","activate","transcription","via","TRE-1","but","this","activation","was","not","dependent","on","Tax","."],"ner_tags":[0,0,0,9,0,0,9,10,0,9,0,0,0,0,0,0,1,0,0,0,0,0,0,0,9,0]}
{"id":"4299","tokens":["cAMP","inhibited","the","induction","of","expression","of","IL-2","receptor","components",",","but","did","not","inhibit","IL-4","receptor","alpha-chain","and","CD69","expression","or","the","induction","of","activator","protein","1","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"16859","tokens":["The","37.5","%","reduction","in","dose","produced","a","23","%","overall","decreased","blood","histamine","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4","tokens":["Delineation","of","the","CD28","signaling","cascade","was","found","to","involve","protein","tyrosine","kinase","activity",",","followed","by","the","activation","of","phospholipase","A2","and","5-lipoxygenase","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0,9,0]}
{"id":"11620","tokens":["These","E1a","reiteration","mutants","could","be","propagated","in","HeLa",",","A549",",","and","KB","cells",";","they","were","genetically","stable",";","and","they","killed","CREF","cells","at","a","strikingly","high","frequency","."],"ner_tags":[0,0,0,0,0,0,0,0,5,0,5,0,0,5,6,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0]}
{"id":"18421","tokens":["Glucocorticoids","are","among","the","most","potent","anti-inflammatory","and","immunosuppressive","agents","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17172","tokens":["At","the","end","of","this","incubation","the","resting","cells","were","stimulated","with","M-CSF",",","and","RNA","was","isolated","for","analysis","by","Northern","blotting","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4288","tokens":["Third",",","a","coimmunoprecipitation","assay","showed","that","in","HTLV-1-infected","human","T","lymphocytes",",","Tax","and","TFIIA","were","associated","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,6,6,0,9,0,9,0,0,0]}
{"id":"1961","tokens":["Clinically",",","it","may","be","postulated","that","disturbed","fetal","brain","development","due","to","prenatal","immune","challenge","increases","the","vulnerability","to","develop","mental","illness","involving","inadequate","responses","to","stress","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4235","tokens":["The","proportion","of","CD40","cells","(","26","%",")","in","a","resting","B-cell","preparation","from","hepatitis","B","patients","decreased","to","zero","after","a","5-day","culture","with","sequence","I",",","but","IgG","levels","in","the","culture","supernatant","increased","."],"ner_tags":[0,0,0,5,6,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1389","tokens":["We","investigated","the","possible","mechanisms","of","estradiol","acting","via","the","polymorphonuclear","leukocytes","(","PMNs",")",",","which","are","important","in","the","immune","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"1742","tokens":["Two","opposite","phenotypes","were","found",",","which","depended","on","the","intracellular","localization","of","Nef","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"6351","tokens":["A","second","complex","contains","hsp90","bound","to","p23","plus","the","three","immunophilins","and","some","hsp70","."],"ner_tags":[0,0,0,0,9,0,0,9,0,0,0,9,0,0,9,0]}
{"id":"9358","tokens":["Expression","of","bcl-6","protein","in","normal","skin","and","epidermal","neoplasms","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0]}
{"id":"4750","tokens":["ML-9","had","little","or","no","effect","on","the","morphology","of","U937","cells","but","increased","the","expression","of","monocyte-macrophage","lineage-associated","surface","antigen",",","CD14",",","to","some","extent","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,9,10,10,10,0,9,0,0,0,0,0]}
{"id":"5696","tokens":["In","contrast",",","activated","T","lymphocytes","from","older","individuals","show","a","significant","reduction","in","the","induction","of","NF","kappa","B","in","response","to","the","same","stimuli","."],"ner_tags":[0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"4938","tokens":["The","immediate-early","gene","egr-1","encodes","a","transcription","factor","(","EGR1",")","that","links","B-cell","antigen","receptor","(","BCR",")","signals","to","downstream","activation","events","through","the","regulation","of","previously","unidentified","target","genes","."],"ner_tags":[0,1,2,1,0,0,9,10,0,9,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"14276","tokens":["Altogether",",","the","data","do","not","provide","any","evidence","to","support","an","assumption","that","moderately","increased","body","burdens","of","PCDDs\/PCDFs","in","adults","induce","decreases","in","the","cellular","components","of","the","human","immune","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2976","tokens":["An","exception","is","the","Bcl-3","protein","which","in","addition","can","function","as","a","transcription","activating","subunit","in","th","nucleus","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,9,10,10,0,0,0,0]}
{"id":"10318","tokens":["Here",",","we","report","that","a","DNA-binding","activity","primarily","consisting","of","the","classical","NF-kappa","B","heterodimer",",","p50\/RelA",",","is","induced","in","phagocytosing","neutrophils","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,7,8,0]}
{"id":"16038","tokens":["These","studies","suggest","that","interaction","of","CD2","with","its","natural","ligand",",","LFA-3",",","may","play","a","role","in","regulation","of","HIV","expression","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14490","tokens":["At","nucleotide","2",",","317","we","identified","a","homozygous","A","for","G","point","mutation","that","predicts","an","isoleucine","(","ATT",")","for","valine","(","GTT",")","substitution","at","amino","acid","729","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4431","tokens":["In","vivo","differentiation","therapy","with","retinoids","in","APL","patients","follows","strict","guidelines","related","both","to","the","APL","cell","and","the","biodisposal","of","all-trans","retinoic","acid","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10058","tokens":["Such","proteasome","activation","correlated","with","hypoxia-evoked","decreases","in","both","extracellular","and","intracellular","pH","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6543","tokens":["The","signal","transduction","events","triggered","by","cross-linking","of","the","CD40","receptor","have","been","widely","studied","in","B","cell","lines",",","but","little","is","known","about","signaling","following","CD40","stimulation","of","monocytes","and","resting","tonsillar","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,9,0,0,7,0,5,6,6,6,0]}
{"id":"5949","tokens":["MBP","stimulated","2-fold","increases","in","IL-8","messenger","RNA","(","mRNA",")","after","1","and","3","h","of","incubation",",","which","were","blocked","by","pretreatment","with","actinomycin","D","."],"ner_tags":[9,0,0,0,0,3,4,4,0,3,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7267","tokens":["In","vitro","studies","on","hematopoietic","control","mechanisms","have","been","hampered","by","the","heterogeneity","of","the","analyzed","cell","populations",",","ie",",","lack","of","lineage","specificity","and","developmental","stage","homogeneity","of","progenitor\/precursor","cells","growing","in","culture","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0]}
{"id":"9594","tokens":["RESULTS",":","Here",",","we","have","isolated","the","murine","and","human","cDNAs","which","encode","a","novel","form","of","MZF","protein","(","MZF-2",")","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,9,10,0,9,0,0]}
{"id":"4673","tokens":["Its","expression","is","restricted","to","a","few","cell","types",",","including","monocyte\/macrophages","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"9629","tokens":["Serum","ACTH","and","IgE","were","measured","by","immunoradiometric","assay",",","and","IL-2",",","IL-4",",","and","IL-10","cytokines","and","interferon-gamma","were","measured","by","enzyme-linked","immunosorbent","assay","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,9,0,9,0,0,9,9,0,9,0,0,0,0,0,0,0]}
{"id":"16220","tokens":["Enhancement","of","human","immunodeficiency","virus","1","replication","in","monocytes","by","1",",","25-dihydroxycholecalciferol","."],"ner_tags":[0,0,0,0,0,0,0,0,7,0,0,0,0,0]}
{"id":"7933","tokens":["Interestingly",",","the","combination","of","1",",","25","(","OH",")","2D3","and","RA","markedly","enhanced","the","levels","of","p27","(","KIP1",")","transcript","and","protein","as","compared","with","levels","induced","by","1",",","25","(","OH",")","2D3","alone","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4613","tokens":["Several","methods","for","specific","down-regulation","of","transcription","factors","are","shown","that","may","be","relevant","to","treatment","of","human","disease","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10160","tokens":["Both","Sp1","and","Sp3","bound","to","the","5","'","portion","of","this","region",",","whereas","a","PMA-inducible","factor","(","PIF",")","mainly","bound","to","its","3","'","portion","and","bound","to","the","Sp","binding","motifs","as","well","."],"ner_tags":[0,9,0,9,0,0,0,1,2,2,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,1,2,2,0,0,0,0,1,2,2,0,0,0]}
{"id":"17553","tokens":["The","two","proteins","differ","in","their","surface","charge",",","since","they","are","separable","by","anion-exchange","chromatography","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16379","tokens":["In","THP-1","cells","with","restricted","HIV","expression",",","there","is","an","absence","of","DNA-protein","binding","complex","formation","with","the","HIV-1","promoter-enhancer","associated","with","markedly","less","viral","RNA","production","."],"ner_tags":[0,5,6,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,1,2,0,0,0,0,3,4,0,0]}
{"id":"13708","tokens":["Finally",",","despite","impaired","Rel-A","translocation",",","T","cells","were","capable","of","transcribing","IL-2","."],"ner_tags":[0,0,0,0,9,0,0,7,8,0,0,0,0,9,0]}
{"id":"12826","tokens":["Costimulation","through","CD28","and\/or","CD2","did","not","modulate","the","CD3","-dependent","phosphorylation","of","HS1","."],"ner_tags":[0,0,9,0,9,0,0,0,0,9,0,0,0,9,0]}
{"id":"7449","tokens":["We","propose","that","Th1","development","can","be","considered","in","two","stages",",","capacitance","and","development","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16404","tokens":["These","findings","therefore","suggest","that","the","HTLV-I","enhancer","contains","multiple","functional","elements",",","including","binding","sites","for","at","least","CREB-","and","NF-kappa","B-like","factors",",","which","synergistically","cooperate","in","activation","of","the","HTLV-I","enhancer","in","response","to","p40tax","."],"ner_tags":[0,0,0,0,0,0,1,2,0,1,2,2,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,1,2,0,0,0,9,0]}
{"id":"5728","tokens":["Furthermore",",","E1A","mutant","proteins","that","can","not","bind","the","cellular","transcriptional","coactivator",",","p300",",","and","that","fail","to","induce","cytolytic","susceptibility","also","failed","to","sensitize","cells","to","injury-induced","apoptosis","."],"ner_tags":[0,0,9,9,10,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6067","tokens":["However",",","signal","transduction","of","IL-10","in","B","cells","is","poorly","understood","."],"ner_tags":[0,0,0,0,0,9,0,7,8,0,0,0,0]}
{"id":"7989","tokens":["Recently",",","its","presence","has","been","demonstrated","in","atherosclerotic","lesions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14877","tokens":["Expression","levels","of","the","thyrotropin","receptor","gene","in","autoimmune","thyroid","disease",":","coregulation","with","parameters","of","thyroid","function","and","inverse","relation","to","major","histocompatibility","complex","classes","I","and","II","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0]}
{"id":"12113","tokens":["These","data","are","the","first","demonstration","of","a","role","for","a","STAT","family","member","in","the","regulation","of","a","viral","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,1,2,0]}
{"id":"13987","tokens":["To","study","the","influence","of","NFkappaB","activity","on","apoptosis","mediated","by","TRAIL",",","CD95",",","TNFalpha",",","or","doxorubicin",",","NFkappaB","activation","was","inhibited","using","the","proteasome","inhibitor","N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal","or","transient","overexpression","of","mutant","IkappaBalpha","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,9,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,9,10,0]}
{"id":"15860","tokens":["Transcription","factor","AP-2","activates","gene","expression","of","HTLV-I","."],"ner_tags":[9,10,10,0,0,0,0,0,0]}
{"id":"3852","tokens":["Characterization","of","the","human","myeloid","cell","nuclear","differentiation","antigen","gene","promoter","."],"ner_tags":[0,0,0,1,2,2,2,2,2,2,2,0]}
{"id":"1218","tokens":["An","early","biochemical","event","associated","with","T","cell","activation","through","the","interleukin-2","receptor","(","IL-2R",")","is","tyrosine","phosphorylation","of","several","intracellular","substrates","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"10634","tokens":["The","control","of","cell","survival","and","cell","death","is","of","central","importance","in","tissues","with","high","cell","turnover","such","as","the","lymphoid","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13522","tokens":["NF-IL6","is","an","important","transcriptional","regulator","of","genes","induced","in","activated","monocytes\/macrophages",",","and","NF-IL6","is","the","only","CCAAT\/enhancer-binding","protein","(","C\/EBP",")","family","member","whose","steady-state","mRNA","levels","increase","upon","activation","of","monocytes","(","1",")","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,7,8,0,0,9,0,0,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0,0,7,0,0,0,0]}
{"id":"8628","tokens":["T-cell","expression","of","the","human","GATA-3","gene","is","regulated","by","a","non-lineage-specific","silencer","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,1,2,0]}
{"id":"14416","tokens":["The","two","structurally","distinct","immunophilin-drug","complexes","bind","to",",","and","inhibit",",","the","phosphatase","activity","of","calcineurin","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,9,0,0,9,0]}
{"id":"12221","tokens":["Demonstration","of","EBV","mRNA","transcripts","encoding","immediate-early","transcriptional","transactivators","in","EBV-infected","T","cells","provides","the","first","evidence","for","a","possible","mechanism","whereby","EBV","could","contribute","to","T","cell","proliferation","and","EBV-associated","T","cell","malignancies","."],"ner_tags":[0,0,3,4,4,0,9,10,10,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"403","tokens":["In","the","present","experiment",",","we","examined","the","effect","of","nm23","proteins","on","various","differentiation","induction","systems","of","human","leukemic","cells","including","HL-60",",","U937",",","HEL\/S",",","KU812F",",","K562",",","and","HEL","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,7,8,8,0,5,6,6,6,6,6,6,6,6,6,6,6,6,0]}
{"id":"3041","tokens":["Cytokine","dysregulation","in","human","immunodeficiency","virus","type","1","(","HIV-1",")","infection","has","been","documented","in","numerous","studies","and","has","been","cited","as","an","important","component","in","the","pathogenesis","of","this","retroviral","infection","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8730","tokens":["Glucocorticoid","resistance","in","the","squirrel","monkey","is","associated","with","overexpression","of","the","immunophilin","FKBP51","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"5818","tokens":["Transient-transfection","assays","showed","that","bcl-x","promoter","was","transactivated","by","wild-type","Tax","."],"ner_tags":[0,0,0,0,1,2,0,0,0,9,10,0]}
{"id":"18539","tokens":["Activation","of","CD4","positive","T","cells","is","a","primary","requirement","for","human","immunodeficiency","virus","(","HIV",")","entry",",","efficient","HIV","replication",",","and","progression","to","AIDS",",","Utilizing","CD4","positive","T","cell","lines","and","purified","T","cells","from","normal","individuals",",","we","have","demonstrated","that","native","envelope","glycoproteins","of","HIV",",","gp","160",",","can","induce","activation","of","transcription","factor",",","activated","protein-1","(","AP-1",")","."],"ner_tags":[0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,0,7,8,8,0,0,0,0,0,0,0,0,9,10,10,0,0,0,9,10,0,0,0,0,0,9,10,10,10,10,0,9,0,0]}
{"id":"7582","tokens":["The","effect","was","dose","dependent","and","appeared","relatively","late","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"1450","tokens":["OBF-1",",","a","novel","B","cell-specific","coactivator","that","stimulates","immunoglobulin","promoter","activity","through","association","with","octamer-binding","proteins","."],"ner_tags":[9,0,0,9,10,10,10,0,0,1,2,0,0,0,0,9,10,0]}
{"id":"18449","tokens":["Transcription","factors","as","targets","for","oxidative","signalling","during","lymphocyte","activation","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0]}
{"id":"2180","tokens":["As","documented","in","the","accompanying","paper","(","Klug","et","al.",",","this","issue",")",",","an","active","v-abl","protein","also","suppresses","the","activity","of","NF-kappa","B\/rel","and","expression","controlled","by","the","kappa","intron","enhancer","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,0,0,0,0,0,1,2,2,0]}
{"id":"11513","tokens":["Clinical","efficacy","and","pharmacokinetics","in","relapsed","patients","."],"ner_tags":[0,0,0,0,0,0,0,0]}
{"id":"4129","tokens":["This","is","the","first","documented","case","of","female","twins","discordant","for","Fabry","disease","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3169","tokens":["The","authors","investigated","whether","there","is","a","correlation","between","HER-2\/neu","expression","and","immunologic","parameters","representing","tumor","defense","in","patients","with","breast","cancer","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8058","tokens":["1.","Bioactivation","of","sulphamethoxazole","(","SMX",")","to","chemically-reactive","metabolites","and","subsequent","protein","conjugation","is","thought","to","be","involved","in","SMX","hypersensitivity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16775","tokens":["NF-kappa","B","is","a","DNA-binding","regulatory","factor","able","to","control","transcription","of","a","number","of","genes",",","including","human","immunodeficiency","virus","(","HIV",")","genes","."],"ner_tags":[9,10,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,0]}
{"id":"7927","tokens":["This","1",",","25","(","OH",")","2D3-induced","G1","arrest","is","enhanced","by","all-trans","RA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9738","tokens":["The","region","of","A-MYB","responsible","for","the","B","cell","specific","activity","was","defined","to","be","the","N-terminal","218","amino","acids","containing","the","DNA","binding","domain","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,9,10,10,0]}
{"id":"10166","tokens":["Moreover",",","Sp1","and","Egr-1","could","form","a","complex","with","kinetics","that","correlated","with","the","production","of","Egr-1","in","Jurkat","cells","upon","PMA","stimulation","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,5,6,0,0,0,0]}
{"id":"14861","tokens":["An","LT","promoter","(","LT-293",")","CAT","construct","that","contained","an","NF-kappa","B","site","was","active","in","the","LT-producing","C81-66-45","cell","line",",","which","contains","defective","HTLV-I","but","expresses","tax","."],"ner_tags":[0,1,2,2,2,2,2,2,0,0,0,1,2,2,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,9,0]}
{"id":"7972","tokens":["In","uterine","pregnancy",",","the","ratio","of","BCL-2","to","CD3","was","0.44","and","0.39","for","CD56","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"4113","tokens":["B-cell-specific","transcription","of","immunoglobulin","genes","is","mediated","by","the","interaction","of","a","POU","domain","containing","transcription","factor","Oct-1","or","Oct-2",",","with","the","B-cell-specific","coactivator","OCA-B","(","Bob-1",",","OBF-1",")","and","a","prototype","octamer","element","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,1,2,0,9,10,9,0,9,0,0,0,9,10,9,0,9,0,9,0,0,0,1,2,2,0]}
{"id":"7924","tokens":["The","cyclin-dependent","kinase","(","cdk",")","inhibitor","p21","(","WAF1\/CIP1",")","has","a","vitamin","D3-responsive","element","(","VDRE",")","in","its","promoter",",","and","1",",","25","(","OH",")","2D3","enhances","the","expression","of","p21","(","WAF1\/CIP1",")","and","induces","differentiation","of","selected","myeloid","leukemic","cell","lines","."],"ner_tags":[0,9,10,10,10,10,10,9,10,10,10,0,0,1,2,2,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,5,6,6,6,0]}
{"id":"15807","tokens":["cis-acting","sequences","required","for","inducible","interleukin-2","enhancer","function","bind","a","novel","Ets-related","protein",",","Elf-1","."],"ner_tags":[1,2,0,0,0,1,2,0,0,0,0,9,10,0,9,0]}
{"id":"5009","tokens":["Moreover","GM-CSF","was","able","to","induce","JAK2","and","p93fes","catalytic","activity","."],"ner_tags":[0,9,0,0,0,0,9,0,9,0,0,0]}
{"id":"9993","tokens":["For","comparison",",","we","recruited","a","control","group","consisting","of","32","healthy","males","and","females","with","similar","age","distribution","and","without","a","history","of","exposure","to","MTBE","or","benzene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17496","tokens":["The","plasma","cortisol","concentration","and","the","sites","of","glucocorticoid","receptor","(","GCR",")","in","the","peripheral","lymphocytes","were","measured","in","32","healthy","aged","persons","and","13","young","adults","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11730","tokens":["The","role","of","cellular","redox","status","in","both","cytotoxic","activity","and","NF-kappa","B","activation","in","natural","killer","(","NK",")","cells","was","investigated","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,7,8,8,8,8,8,0,0,0]}
{"id":"3215","tokens":["Tumor","necrosis","factor","receptor-1","(","TNFR-1",")","and","CD95","(","also","called","Fas","or","APO-1",")","are","cytokine","receptors","that","engage","the","apoptosis","pathway","through","a","region","of","intracellular","homology",",","designated","the","``","death","domain",".","''","Another","death","domain-containing","member","of","the","TNFR","family",",","death","receptor","3","(","DR3",")",",","was","identified","and","was","shown","to","induce","both","apoptosis","and","activation","of","nuclear","factor","kappaB","."],"ner_tags":[9,10,10,10,0,9,0,0,9,0,0,0,9,0,9,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,0,0,9,10,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"16011","tokens":["We","report","the","structure","and","regulation","of","a","gene","represented","by","clone","pAT","133",",","which","is","induced","upon","transition","from","a","resting","state","(","G0",")","through","the","early","phase","of","the","cell","cycle","(","G1",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6857","tokens":["To","find","out","if","the","induction","by","UV","light","is","caused","by","the","formation","of","an","Ah","receptor","ligand",",","Hepa-1","wild-type","and","Ah","receptor","deficient","c12","cell","lines","were","applied","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,6,6,0,0,0]}
{"id":"14256","tokens":["They","are","part","of","the","high","affinity","IgE","receptor","in","mast","cells",",","basophils",",","Langerhans","cells",",","and","possibly","other","cells",";","a","component","of","the","low","affinity","receptor","for","IgG","(","Fc","gamma","RIIIA","or","CD16",")","in","natural","killer","cells","and","macrophages",";","and","part","of","the","T","cell","antigen","receptor","in","subsets","of","T","cells","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,7,8,0,7,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,10,0,9,0,0,0,7,8,0,7,0,0,0,0,0,9,10,10,10,0,0,0,7,8,0]}
{"id":"18500","tokens":["We","show","that","the","expression","of","four","cell","genes",",","cdc-2",",","cyclin","E",",","CD23",",","and","cyclin","D2",",","are","up-regulated","approximately","100-fold","as","a","result","of","EBV-mediated","immortalization","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,1,0,1,2,0,1,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11358","tokens":["The","results","described","here","indicate","that","cognate","interaction","of","B","cells","recognizing","DNA","or","DNA-associated","proteins","and","T","cells","recognizing","T","antigen","had","taken","place","as","a","consequence","of","complex","formation","between","T","ag","and","DNA","in","vivo","in","the","context","of","polyomavirus","reactivations","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,8,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"201","tokens":["Chronic","myelogenous","leukemia","evolves","in","two","clinically","distinct","stages",":","a","chronic","and","a","blast","crisis","phase","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4158","tokens":["This","revealed","that","NF-kappaB","generation","was","sensitive","to","chloroquine",",","an","inhibitor","of","acidic","sphingomyelinase",",","but","not","to","the","phosphatidylinositol","3-kinase","inhibitor",",","wortmannin","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"14831","tokens":["In","addition",",","our","results","indicate","that","the","tal-1","1A","promoter",",","which","contains","two","consensus","GATA-binding","sites",",","is","active","mainly","in","these","lineages","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0]}
{"id":"14494","tokens":["The","transcriptionally","active","factors","mediating","the","effect","of","the","HTLV-I","Tax","transactivator","on","the","IL-2R","alpha","kappa","B","enhancer","include","the","product","of","the","c-rel","proto-oncogene","."],"ner_tags":[0,9,10,10,0,0,0,0,0,9,10,10,0,0,1,2,2,2,2,0,0,0,0,0,1,2,0]}
{"id":"8022","tokens":["In","contrast",",","treatment","of","HL-60","cells","with","retinoic","acid","or","DMSO",",","which","results","in","a","granulocytic","differentiation","of","these","cells",",","decreases","4E-BP1","amount","without","affecting","its","phosphorylation","and","strongly","increases","4E-BP2","amount","."],"ner_tags":[0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"8709","tokens":["These","transcription","factors","are","either","not","produced","due","to","block","of","transcription","of","their","respective","genes","(","Oct-2",",","OBF-1",",","PU.1",")",",","or","are","rendered","inactive","posttranslationally","(","NF-kappa","B",",","E47",")","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,9,0,0,0,0,0,0,0,0,9,10,0,1,0,0]}
{"id":"2090","tokens":["Autocrine","role","of","tumor","necrosis","factor","alpha","."],"ner_tags":[0,0,0,9,10,10,10,0]}
{"id":"4274","tokens":["Increasing","the","levels","of","BCL-2","retarded","the","G0","--",">","S","transition",",","sustained","the","levels","of","cyclin-dependent","kinase","inhibitor","p27Kip1",",","and","repressed","postactivation","death","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"14643","tokens":["The","enhancer","for","the","immunoglobulin","mu","heavy","chain","gene","(","IgH",")","activates","a","heterologous","gene","at","the","pre-B","cell","stage","of","B","lymphocyte","differentiation","."],"ner_tags":[0,1,0,0,1,2,2,2,2,0,9,0,0,0,1,2,0,0,0,0,0,0,7,8,0,0]}
{"id":"11434","tokens":["NF-AT","and","NF-kappaB","were","not","significantly","induced","by","IL-2","stimulation","."],"ner_tags":[9,0,9,0,0,0,0,0,9,0,0]}
{"id":"6175","tokens":["These","analyses","demonstrated","that","the","[","3H","]","aldosterone-","MBP-HBD","complex","is","at","least","associated","with","hsp90","in","reticulocyte","lysate","and","that","the","HBD","of","hMR","is","sufficient","to","bind","hsp90","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0,0,9,0]}
{"id":"15123","tokens":["Sequence","variation","in","the","long","terminal","repeat","(","LTR",")","region","of","HIV-1","was","analyzed","in","viral","isolates","of","17","infected","individuals","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6667","tokens":["In","both","atopic","and","nonatopic","asthma",",","elevated","IL-5","has","been","detected","in","peripheral","blood","and","the","airways","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"10776","tokens":["T","cell","receptor","(","TCR",")","alpha","and","delta","gene","segments","are","organized","within","a","single","genetic","locus","but","are","differentially","regulated","during","T","cell","development","."],"ner_tags":[9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13769","tokens":["Transfection","experiments","showed","that","both","Stat1alpha","and","Stat3","inhibited","the","induction","by","EPO","of","gamma-globin","and","erythroid-specific","5-aminolevulinate","synthetase","transcripts",",","resulting","in","a","reduction","of","the","percentage","of","hemoglobin-positive","cells","."],"ner_tags":[0,0,0,0,0,9,0,9,0,0,0,0,9,0,3,4,4,4,4,4,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"11303","tokens":["ALY",",","a","context-dependent","coactivator","of","LEF-1","and","AML-1",",","is","required","for","TCRalpha","enhancer","function","."],"ner_tags":[9,0,0,9,10,0,9,0,9,0,0,0,0,1,2,0,0]}
{"id":"1114","tokens":["From","the","present","and","previous","data",",","eighteen","different","KOX","genes","have","been","located","at","least","two","by","two","within","nine","DNA","fragments","of","200","to","580","kb","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0]}
{"id":"10148","tokens":["Glucocorticoid","receptor","regulates","expression","of","L-selectin","and","CD11\/CD18","on","human","neutrophils","[","see","comments","]"],"ner_tags":[9,10,0,0,0,9,0,9,0,7,8,0,0,0,0]}
{"id":"10211","tokens":["However",",","analysis","of","deletion","mutants","localized","nearly","all","of","the","promoter","activity","to","a","short","region","(","-73","to","-16",")","that","did","not","include","the","cluster","of","c-Myb","sites","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"1775","tokens":["However",",","reagents","such","as","nerve","growth","factor","(","NGF",")","and","the","phorbol","ester","phorbol","12-myristate","13-acetate","(","PMA",")",",","which","induce","phenotypical","differentiation","of","the","SH-SY5Y","neuroblastoma","cell","line",",","activated","NF-kappa","B",",","but","only","in","that","particular","cell","line","."],"ner_tags":[0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,9,10,0,0,0,0,0,0,5,6,0]}
{"id":"13553","tokens":["Western","analysis","performed","on","cellular","fractions","of","resting","cells","and","of","TPA-activated","cells","revealed","abundant","expression","of","classical","PKC-alpha","(","cPKC-alpha",")",",","cPKC-betaII",",","and","atypical","PKC-zeta","isoforms","and","identified","a","sustained","translocation","of","cPKC-alpha","and","cPKC-betaII","from","the","cytosolic","compartment","to","membranes","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,7,8,0,0,0,0,9,10,0,9,0,0,9,0,0,9,10,10,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"2413","tokens":["After","dexamethasone","suppression","(","1","mg","at","11","p.m.",")","Type","I","receptors","always","decrease","in","controls","while","the","response","of","Type","II","is","not","homogeneous","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"16956","tokens":["Mutation","of","the","hXBP-1","DNA","target","sequence","decreased","DR","alpha","promoter","activity","in","vivo","."],"ner_tags":[0,0,0,1,2,2,2,0,1,2,2,0,0,0,0]}
{"id":"14759","tokens":["Although","TR55","expression","was","unaltered","during","TNF-alpha","-induced","HIV","activation",",","this","receptor","was","still","involved","in","the","viral","activation","process","."],"ner_tags":[0,9,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7321","tokens":["The","development","and","function","of","T","lymphocytes","are","regulated","tightly","by","signal","transduction","pathways","that","include","specific","cell-surface","receptors",",","intracellular","signaling","molecules",",","and","nuclear","transcription","factors","."],"ner_tags":[0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,10,0,0,9,10,10,0]}
{"id":"895","tokens":["The","use","of","glucocorticoids","in","acute","lymphoblastic","leukemia","of","childhood","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10444","tokens":["Human","cytomegalovirus","induces","interleukin-8","production","by","a","human","monocytic","cell","line",",","THP-1",",","through","acting","concurrently","on","AP-1-","and","NF-kappaB-binding","sites","of","the","interleukin-8","gene","."],"ner_tags":[0,0,0,9,0,0,0,5,6,6,6,0,5,0,0,0,0,0,1,2,2,2,0,0,1,2,0]}
{"id":"8175","tokens":["To","investigate","its","biological","role",",","we","generated","transgenic","mice","expressing","E2A-HLF","using","Ig","enhancer","and","promoter",",","which","direct","transgene","expression","in","cells","committed","to","the","lymphoid","lineage","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11914","tokens":["Pivotal","role","for","the","NFIL3\/E4BP4","transcription","factor","in","interleukin","3","-mediated","survival","of","pro-B","lymphocytes","."],"ner_tags":[0,0,0,0,9,10,10,0,9,10,0,0,0,7,8,0]}
{"id":"8934","tokens":["Inhibition","of","the","MAP","kinase","cascade","with","PD98059",",","a","specific","inhibitor","of","MAPK","kinase","1",",","prevented","the","expression","of","the","alpha2","integrin","subunit","in","cells","induced","to","become","megakaryocytic","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0]}
{"id":"11982","tokens":["Rather",",","the","binding","affinity","is","probably","influenced","by","the","expression","of","cytosolic","factors","that","affect","glucocorticoid","receptor","function","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,0,0]}
{"id":"5317","tokens":["This","resulted","in","concomitant","decrease","in","nuclear","NF-kappaB","DNA-binding","activity","and","endogenous","long","terminal","repeat","transcriptional","activity","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,1,2,2,2,0,0,0]}
{"id":"16406","tokens":["Human","tumor","necrosis","factor","alpha","gene","regulation","in","phorbol","ester","stimulated","T","and","B","cell","lines","."],"ner_tags":[0,9,10,10,10,0,0,0,0,0,5,6,6,6,6,6,0]}
{"id":"11925","tokens":["To","test","this","hypothesis",",","a","more","sensitive","and","specific","polymerase","chain","reaction","(","PCR",")","assay","was","developed","to","detect","adenovirus","DNA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16798","tokens":["The","purified","homodimer","(","two","p50s",")","of","the","DNA-binding","subunit","of","NF-kappa","B","binds","the","B2","site","of","proenkephalin","relatively","better","than","does","the","heterotetramer","(","two","p65s","plus","two","p50s",")","form","of","the","factor","."],"ner_tags":[0,0,9,0,0,9,0,0,0,9,10,0,9,10,0,0,1,0,0,0,0,0,0,0,0,9,0,0,9,0,0,9,0,0,0,0,0,0]}
{"id":"17884","tokens":["p50","is","translated","as","a","precursor","of","105","kDa","."],"ner_tags":[9,0,0,0,0,0,0,9,10,0]}
{"id":"11568","tokens":["CONCLUSIONS",":","The","reduction","of","symptoms","due","to","topical","fluticasone","propionate","in","patients","with","rhinitis","and","allergy","to","house","dust","mite","is","not","correlated","with","the","characteristics","of","the","glucocorticoid","receptor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"803","tokens":["STAT-1","was","tyrosine","phosphorylated","within","15","min","of","IL-5","stimulation","."],"ner_tags":[9,0,0,0,0,0,0,0,9,0,0]}
{"id":"11647","tokens":["Clinical","deterioration","in","human","immunodeficiency","virus","type","1","(","HIV-1",")","infection","is","associated","with","increased","levels","of","viral","replication","and","burden","in","the","peripheral","blood","and","lymphoid","organs","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12396","tokens":["This","beneficial","effect","is","mediated",",","in","part",",","by","inhibition","of","inflammatory","cytokine","production",",","including","tumor","necrosis","factor-alpha","(","TNF-alpha",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,0,9,0,0]}
{"id":"14729","tokens":["The","effects","of","these","substitutions","on","viral","replication","in","transfected","HeLa","cells","and","on","HIV","infection","of","human","peripheral","blood","lymphocytes","or","continuous","T-leukemia","cell","lines","were","evaluated","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,7,8,8,8,0,5,6,6,6,0,0,0]}
{"id":"14753","tokens":["METHODS",":","TNF","receptor","surface","expression","was","determined","by","specific","monoclonal","antibody","recognition","and","flow","cytometry",",","and","signal","transduction","was","detected","by","gel","shift","analysis","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10035","tokens":["Indirect","evidence","suggested","that","allele","T","is","less","stable","than","allele","t","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,1,2,0]}
{"id":"13470","tokens":["Our","investigations","have","focused","on","localizing","cis-elements","responsible","for","the","down","regulation","of","the","adult","beta-like","globin","genes","(","delta","and","beta",")","in","immature",",","or","primitive","erythroid","tissues","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,2,2,2,0,1,0,1,0,0,0,0,0,0,0,0,0]}
{"id":"14029","tokens":["OBJECTIVE",":","To","identify","and","characterize","estrogen","receptor","(","ER",")","transcripts","expressed","in","immune","cells","of","patients","with","systemic","lupus","erythematosus","(","SLE",")","and","healthy","donors","."],"ner_tags":[0,0,0,0,0,0,3,4,4,4,4,4,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10410","tokens":["We","have","examined","the","effects","of","N-acetyl-L-cysteine","(","NAC",")",",","a","well-characterized",",","thiol-containing","antioxidant",",","on","agonist-induced","monocytic","cell","adhesion","to","endothelial","cells","(","EC",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,0,0]}
{"id":"16622","tokens":["It","was","found","that","the","number","of","ER","in","leucocytes","was","significantly","increased","in","gynecomastia","(","Rs","of","leucocytes","were","1054","+\/-","254","sites\/cell",")","."],"ner_tags":[0,0,0,0,0,0,0,9,0,7,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0]}
{"id":"15333","tokens":["We","have","studied","the","regulation","of","AP-1","activity","in","human","peripheral","blood","T","lymphocytes","stimulated","through","the","activation","inducer","molecule","(","AIM",")","\/","CD69","activation","pathway","."],"ner_tags":[0,0,0,0,0,0,9,0,0,7,8,8,8,8,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"7713","tokens":["These","data","collectively","suggest","that","PAO","interferes","with","the","phosphorylation","and","the","regulated","degradation","of","IkappaB-alpha",",","induced","by","TNF",",","without","affecting","the","chymotryptic","activity","of","the","proteasome",",","independent","of","age","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"1664","tokens":["Comparison","of","the","SBMA","sperm","typing","results","with","mutation","frequency","data","on","normal","alleles","supports","the","hypothesis","that","trinucleotide","repeat","expansions","may","have","a","different","molecular","origin","than","contractions","."],"ner_tags":[0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"5681","tokens":["Additionally",",","E2F-1","caused","massive","megakaryocyte","accumulation","in","both","normal","and","ectopic","sites",",","first","evident","in","E15","embryonic","liver","."],"ner_tags":[0,0,9,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5410","tokens":["The","up-regulation","of","galectin-3","expression","appeared","to","correlate","well","with","HTLV-I","gene","expression",",","as","undetectable","or","very","low","levels","of","galectin-3","were","found","in","the","S1T","and","ATL-1K","cell","lines",",","which","are","nonproductively","infected","with","HTLV-I","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,5,6,6,6,6,0,0,0,0,0,0,0,0]}
{"id":"316","tokens":["The","components","tyrosine","phosphorylated","subsequent","to","cell","adhesion","include","paxillin",",","pp125FAK",",","and","the","SH2","domain","containing","tyrosine","kinase","Syk","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,9,10,10,10,10,10,0]}
{"id":"2987","tokens":["These","clones","were","tested","for","their","recognition","of","BCR1\/25","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"16492","tokens":["A","transcript","of","the","ALAS","IRE",",","mutated","in","the","conserved","loop","of","the","IRE",",","did","not","readily","form","this","protein","-","RNA","complex","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"10629","tokens":["In","addition",",","LPS","stimulation","induced","the","binding","of","cognate","nuclear","factors","to","the","Egr-1","and","kappaB3","sites",",","which","were","identified","as","Egr-1","and","p50\/p65",",","respectively","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,1,2,2,2,0,0,0,0,0,9,0,9,0,0,0]}
{"id":"3205","tokens":["However",",","none","of","these","proximal","regions","account","for","the","induction","of","IL-2R","alpha","transcription","by","IL-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"13227","tokens":["The","activation","status","of","the","chromosomes","involved","in","the","translocation","was","determined","by","simultaneous","immunocytogenetic","studies","using","antibodies","against","either","BrdU","incorporated","at","late","S","phase","or","acetylated","histone","H4","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,9,10,10,0]}
{"id":"4978","tokens":["IL-10","inhibits","nuclear","factor-kappa","B\/Rel","nuclear","activity","in","CD3-stimulated","human","peripheral","T","lymphocytes","."],"ner_tags":[9,0,9,10,10,0,0,0,5,6,6,6,6,0]}
{"id":"18430","tokens":["VDR","DNA-binding","mutants","were","unable","to","either","bind","to","this","element","in","vitro","or","repress","in","vivo",";","the","VDR","DNA-binding","domain","alone",",","however",",","bound","the","element","but","also","could","not","repress","IL-2","expression","."],"ner_tags":[9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"3223","tokens":["A","constitutive","NF-kappa","B","activity","has","been","reported","in","mature","macrophages","."],"ner_tags":[0,0,9,10,0,0,0,0,0,7,8,0]}
{"id":"6275","tokens":["Hence",",","when","N-WASP","is","activated",",","its","COOH-terminal","domain","feeds","barbed","end","growth","of","filaments","and","lowers","the","critical","concentration","at","the","bacterial","surface","."],"ner_tags":[0,0,0,9,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3957","tokens":["We","propose","that","direct","interaction","between","the","glucocorticoid","receptor","and","nuclear","factor-kappa","B","factors","is","at","least","a","partial","explanation","for","the","effects","of","this","hormone","in","inflammatory","diseases","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10628","tokens":["LPS","stimulation","increased","the","binding","of","c-Jun-containing","complexes","."],"ner_tags":[0,0,0,0,0,0,9,10,0]}
{"id":"10346","tokens":["Such","repression","imposes","a","requirement","for","both","c-Myb","and","Ets","for","transcriptional","activity",",","providing","one","explanation","for","why","synergy","between","these","factors","is","important","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10229","tokens":["In","a","previous","study",",","we","demonstrated","that","bufalin",",","which","is","an","active","principle","of","Chinese","medicine",",","chan'su",",","caused","apoptosis","in","human","leukemia","U937","cells","by","anomalous","activation","of","mitogen-activated","protein","kinase","(","MAPK",")","via","the","signaling","pathway","of","Ras",",","Raf-1",",","and","MAPK","kinase-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,9,0,9,0,0,9,10,0]}
{"id":"1227","tokens":["The","tax","gene","product","of","human","T-cell","leukemia","virus","type","I","(","HTLV-I",")","is","a","potent","transcriptional","activator","that","both","stimulates","viral","gene","expression","and","activates","an","array","of","cellular","genes","involved","in","T-cell","growth","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,7,0,0]}
{"id":"11263","tokens":["We","and","others","have","shown","that","SAA","gene","is","induced","in","monocyte\/macrophage","cells","by","lipopolysaccharide","(","LPS",")","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"15405","tokens":["The","S.","cerevisiae","and","Sch.","pombe","systems","support","effects","of","acidic","activator","proteins",",","provided","a","further","protein","fraction","from","S.","cerevisiae","is","supplied","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4080","tokens":["To","confirm","the","importance","of","the","three","cis-acting","elements","in","the","perforin","gene","expression",",","point","mutation","was","introduced","again","to","each","proximal","GC","box",",","EBS",",","and","GT","box","of","PFP5a","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,1,2,0,0,0,0,0,0,0,0,0,1,2,2,0,1,0,0,1,2,0,1,0]}
{"id":"1326","tokens":["We","distinguish","the","stimuli-specific","pathways","by","showing","that","the","oxidative","stimuli","trigger","NF-kappa","B","activation","in","only","one","of","two","human","T-cell","lines","(","Wurzburg","but","not","Jurkat",")",",","whereas","tumor","necrosis","factor","alpha","and","phorbol","12-myristate","13-acetate","readily","stimulate","in","both","lines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,5,6,6,0,5,0,0,5,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"12879","tokens":["Recent","studies","reveal","that","a","family","of","transcription","factors",",","signal","transducers","and","activators","of","transcription","(","STATs",")","directly","mediate","many","cytokine","signals","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,10,10,10,10,10,0,9,0,0,0,0,9,0,0]}
{"id":"1478","tokens":["The","NS-Meg","cells","spontaneously","produced","platelet-like","particles","which","contained","alpha-granules",",","mitochondria","and","dense","bodies",",","strongly","suggesting","platelet","production","."],"ner_tags":[0,5,6,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5153","tokens":["Transient","expression","of","p16","in","normal","human","lymphocytes","caused","arrest","in","G1",",","but","was","without","effect","on","the","cell","growth","of","MOLT-4","and","CEM","cells",",","although","all","of","them","express","functional","retinoblastoma","protein","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,9,10,0]}
{"id":"4030","tokens":["Epithelial","cells","are","the","major","site","of","lytic","EBV","replication","within","the","human","host",",","and","viral","reactivation","occurs","in","EBV-associated","nasopharyngeal","carcinomas","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14948","tokens":["In","the","present","studies","we","have","examined","the","signaling","pathways","by","which","this","monocyte-specific","response","is","induced","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1872","tokens":["In","vivo","protein-DNA","contacts","are","detectable","at","Ii","kappa","B-1","in","cell","lines","in","which","this","site","is","functional","as","either","a","positive","or","negative","regulator","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,0,5,6,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"14681","tokens":["In","contrast",",","c-fos","mRNA","is","absent","from","resting","T","cells","and","is","induced","on","PHA","activation","."],"ner_tags":[0,0,0,3,4,0,0,0,0,7,8,0,0,0,0,9,0,0]}
{"id":"14117","tokens":["Tumor","samples",",","obtained","from","129","patients","who","underwent","surgery","between","January","1987","and","December","1988",",","were","processed","for","staining","by","an","immunohistochemical","procedure","(","avidin-biotin","complex",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"17053","tokens":["Low","levels","of","c-jun","transcripts","were","detectable","in","untreated","HL-60","leukemic","cells",",","increased","significantly","by","6","h",",","and","reached","near","maximal","levels","by","24","h","of","exposure","to","32","nM","TPA","."],"ner_tags":[0,0,0,3,4,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3920","tokens":["Furthermore",",","an","inverse","relationship","was","also","observed","between","the","LDL","receptor","gene","expression","at","the","transcriptional","level","and","the","binding","affinity","of","this","47","kDa","protein","factor","to","the","SRE","sequence","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,1,2,0]}
{"id":"13139","tokens":["Increased","expression","of","Egr-1","was","observed","with","macrophage","differentiation","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0]}
{"id":"13457","tokens":["Addition","of","ASA","to","an","in","vitro","T","helper","cell","differentiation","system",",","at","concentrations","compatible","with","plasma","levels","reached","during","anti-inflammatory","therapy",",","resulted","in","reduced","development","of","Th1","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"8666","tokens":["Regulation","of","IL-4","expression","by","the","transcription","factor","JunB","during","T","helper","cell","differentiation","."],"ner_tags":[0,0,9,0,0,0,9,10,9,0,0,0,0,0,0]}
{"id":"2495","tokens":["The","cascade","of","events","within","the","first","few","minutes","of","T","cell","stimulation","has","been","well","characterized","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"2564","tokens":["Very","little","information","exists","linking","these","two","important","classes","of","signaling","molecules","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"5579","tokens":["Thrombopoietin","induces","tyrosine","phosphorylation","of","Stat3","and","Stat5","in","human","blood","platelets","."],"ner_tags":[9,0,0,0,0,9,0,9,0,7,8,8,0]}
{"id":"12648","tokens":["In","agreement","with","this",",","decrease","in","the","insulin","mRNA","and","insulin","content","was","observed","in","the","glycation-induced","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,7,8,0]}
{"id":"17584","tokens":["Pd-C","hydrogenation","of","its","diacetate","14","afforded","the","4",",","5-dihydro","derivative","18",",","19-chloro-21-acetoxypregn-9","(","11",")","-en-20-one","(","15",")",",","its","4-acetoxy","derivative","16","and","the","3",",","4-diacetoxy","derivative","17","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3416","tokens":["Nasal","T\/NK-cell","lymphomas","can","be","further","separated","into","those","of","natural","killer","(","NK",")","cell","lineage","or","of","T-cell","lineage",",","with","differences","in","cellular","phenotype",",","T-cell","receptor","(","TcR",")","gene","rearrangement","and","TcR","transcript","expression","."],"ner_tags":[7,8,8,0,0,0,0,0,0,0,7,8,8,8,8,8,8,0,0,7,8,0,0,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,0]}
{"id":"13875","tokens":["The","cells","were","then","stimulated","for","6","h","."],"ner_tags":[0,0,0,0,0,0,0,0,0]}
{"id":"9322","tokens":["Switching","gears","during","T-cell","maturation",":","RANTES","and","late","transcription","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0]}
{"id":"3722","tokens":["Here",",","we","report","that","differentiated","B","cells","contain","a","novel","substoichiometric","TAF","of","105","kDa","not","found","associated","with","TFIID","isolated","from","other","cell","types","."],"ner_tags":[0,0,0,0,0,7,8,8,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"14584","tokens":["The","composition","of","NF-AT","protein","is","still","not","fully","elucidated","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0]}
{"id":"571","tokens":["The","effect","of","treatment","on","thyroid","antibody","production","and","T","cell","reactivity","to","thyroid","antigens","was","studied","in","15","patients","with","Graves","'","disease","(","GD",")","before","and","after","thyroidectomy",",","19","patients","with","GD","before","and","after","radioactive","iodine","(","RAI",")","therapy",",","and","9","patients","maintained","euthyroid","on","antithyroid","drugs","(","ATD",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13996","tokens":["The","human","PAX-5","gene","was","recently","shown","to","participate","together","with","the","IgH","locus","in","the","chromosomal","translocation","t","(","9",";","14",")","(","p13",";","q32",")","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,1,2,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0]}
{"id":"8817","tokens":["They","may","represent","immunoregulatory","cells",",","and","further","analysis","of","these","cells",",","and","a","comparison","to","those","found","in","patients","with","SS",",","may","elucidate","normal","immunoregulation","and","the","derangements","that","lead","to","Sjogren","'s","syndrome","."],"ner_tags":[0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4439","tokens":["In","contrast","to","IL-2","and","IFN-alpha",",","IL-12","induced","strong","tyrosine","phosphorylation","of","STAT4","and","variable","weak","phosphorylation","of","STAT3","."],"ner_tags":[0,0,0,9,0,9,0,9,0,0,0,0,0,9,0,0,0,0,0,9,0]}
{"id":"9431","tokens":["EBNA3C","is","a","potent","repressor","of","transcription","when","bound","to","DNA","as","a","fusion","with","the","DNA","binding","domain","(","DBD",")","of","GALA","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0]}
{"id":"2081","tokens":["We","recently","confirmed","the","existence","of","gelatinase","granules","as","a","subpopulation","of","peroxidase-negative","granules","by","double-labeling","immunogold","electron","microscopy","on","intact","cells","and","by","subcellular","fractionation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9701","tokens":["Our","findings","demonstrate","that","truncated","TSG101","and","FHIT","transcripts","are","commonly","detected","in","both","normal","and","malignant","tissues","and","that","a","significant","fraction","of","these","are","likely","to","be","the","result","of","aberrant","splicing","."],"ner_tags":[0,0,0,0,3,4,4,4,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10789","tokens":["Thus",",","the","availability","of","these","variant","cells","should","provide","a","system","for","studying","the","link","between","differentiation","and","cell","cycle","arrest","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8282","tokens":["Though","the","levels","of","DP1","and","-2","increase","when","cells","progress","from","G0","to","S",",","the","proportion","of","DP1","to","DP2","remains","relatively","constant","during","the","cell","cycle","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0]}
{"id":"6038","tokens":["It","is","generally","assumed","that","most","mammalian","genes","are","transcribed","from","both","alleles","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,0,0,1,0]}
{"id":"389","tokens":["The","AP-1","binding","proteins","contained","c-Jun",",","Jun-D",",","and","Fra-1",",","but","marginal","amounts","of","Jun-B","and","c-Fos","."],"ner_tags":[0,9,10,10,0,9,0,9,0,0,9,0,0,0,0,0,9,0,9,0]}
{"id":"15941","tokens":["In","Jurkat","and","NC2.10","induction","with","phorbol","esters","resulted","in","the","appearance","of","new","DNA","binding","proteins","of","85",",","75",",","and","54","kDa",",","whereas","in","Tax","expressing","cells","the","85-kDa","protein","and","a","92-kDa","DNA","binding","protein","were","constitutively","induced","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,10,10,10,10,10,10,0,0,0,5,6,6,0,9,10,0,0,9,10,10,10,0,0,0,0]}
{"id":"12464","tokens":["Although","cadmium","caused","an","early",",","transient","stimulation","of","c-jun","and","c-fos","expression","and","AP-1","binding","activity",",","heat-shock","failed","to","alter","both","protooncogene","expression","and","transcription","factor","binding",",","indicating","that","the","stress-induced","vimentin","increase","was","not","the","result","of","AP-1","-mediated","transcriptional","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,0,1,0,0,9,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"12949","tokens":["A","subsequent","transfection","of","these","apparently","``","nonresponsive","''","clones","allows","the","recovery","of","Tax","responses","in","these","cells","."],"ner_tags":[0,0,0,0,0,0,5,6,6,6,0,0,0,0,9,0,0,0,0,0]}
{"id":"8388","tokens":["Binding","of","HMG-I","(","Y",")","elicits","structural","changes","in","a","silencer","of","the","human","beta-globin","gene","."],"ner_tags":[0,0,9,10,10,10,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"17688","tokens":["The","hierarchy","of","transcriptional","control","in","B-cell","development","has","recently","been","analyzed","by","targeted","gene","inactivation","in","the","mouse","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12730","tokens":["In","contrast",",","luciferase","expression","was","not","stimulated","after","IFN-gamma","treatment","when","the","construct","was","transfected","in","macrophage","or","in","epithelial","cell","lines","."],"ner_tags":[0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"227","tokens":["To","test","the","hypothesis","that","nitric","oxide","(","NO",")","limits","endothelial","activation",",","we","treated","cytokine-stimulated","human","saphenous","vein","endothelial","cells","with","several","NO","donors","and","assessed","their","effects","on","the","inducible","expression","of","vascular","cell","adhesion","molecule-1","(","VCAM-1",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0]}
{"id":"16754","tokens":["From","HeLa","cells",",","two","major","proteins","of","52","and","45","kilodaltons","(","kD",")","copurified","with","DNA","binding","activity",",","whereas","from","T-cells",",","four","proteins","--","a","major","protein","of","52","kD","and","three","minor","proteins","of","82",",","67",",","and","43-47","kD","--","were","purified","."],"ner_tags":[0,5,6,0,0,0,0,0,9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,7,0,0,0,0,0,9,10,0,9,10,0,0,9,10,0,9,0,9,0,0,9,10,0,0,0,0]}
{"id":"3945","tokens":["In","this","study",",","we","examined","the","molecular","mechanism","by","which","agents","that","elevate","intracellular","cAMP","inhibit","the","expression","of","the","tumor","necrosis","factor","alpha","(","TNFalpha",")",",","tissue","factor",",","endothelial","leukocyte","adhesion","molecule-1",",","and","vascular","cell","adhesion","molecule-1","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0,9,10,0,9,10,10,10,0,0,1,2,2,2,2,0]}
{"id":"4492","tokens":["STAT5A-STAT5A","homodimers","and","STAT5A-STAT5B","heterodimers","formed","in","response","to","GM-CSF","."],"ner_tags":[9,10,0,9,10,0,0,0,0,9,0]}
{"id":"8757","tokens":["Sequencing","of","the","GR","cDNA","and","gene","including","the","2.3-kb","coding","region",",","the","intron\/exon","junctions",",","the","known","5'-regulatory","region",",","and","approximately","300","bp","of","the","3'-region","revealed","no","alterations","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,1,0,0,0,0]}
{"id":"12381","tokens":["Conversely",",","IL-4","and","IL-13","markedly","and","significantly","inhibited","HIV","replication","at","the","transcriptional","level","in","monocyte-derived","macrophages",",","and","this","occurred","whether","these","cytokines","were","added","before","or","after","HIV","infection","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"3096","tokens":["Association","of","TRAF1",",","TRAF2",",","and","TRAF3","with","an","Epstein-Barr","virus","LMP1","domain","important","for","B-lymphocyte","transformation",":","role","in","NF-kappaB","activation","."],"ner_tags":[0,0,9,0,9,0,0,9,0,0,1,2,2,2,0,0,7,0,0,0,0,9,0,0]}
{"id":"5007","tokens":["We","have","previously","shown","that","JAK2","becomes","tyrosine-phosphorylated","in","response","to","GM-CSF","in","PMN","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,9,0,7,0]}
{"id":"5751","tokens":["We","also","investigated","the","effects","of","stimulating","T","cell","blasts","with","CD80","alone","and","found","that","there","was","a","limited","requirement","for","IL-2","in","this","system","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,0,9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"7871","tokens":["Beta-catenin","is","the","vertebrate","homolog","of","the","Drosophila","segment","polarity","gene","Armadillo","and","plays","roles","in","both","cell-cell","adhesion","and","transduction","of","the","Wnt","signaling","cascade","."],"ner_tags":[0,0,0,0,0,0,0,1,2,2,2,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5019","tokens":["We","propose","that","growth","inhibition","of","established","B","cell","lymphoma","lines","is","a","novel","function","of","EBNA2","which","has","not","been","detected","in","the","absence","of","an","inducible","system","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8745","tokens":["The","cotransfection","of","this","LTR","with","a","mutated","IkappaBalpha","molecule","formally","demonstrates","that","LTR","transactivation","is","regulated","by","members","of","the","Rel\/NF-kappaB","family","in","thymocytes","."],"ner_tags":[0,0,0,0,1,0,0,0,9,10,0,0,0,1,0,0,0,0,0,0,0,9,10,0,7,0]}
{"id":"342","tokens":["This","suggest","that","they","may","interact","with","a","new","family","of","trans-acting","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"11973","tokens":["The","squirrel","monkey","glucocorticoid","receptor","is","approximately","97","%","identical","in","nucleotide","and","amino","acid","sequence","to","the","human","receptor","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"4489","tokens":["Freshly","isolated","monocytes","expressed","94-kD","STAT5A",",","92-kD","STAT5B",",","and","an","80-kD","STAT5A","molecule","."],"ner_tags":[0,0,0,0,9,10,0,0,9,0,0,0,9,10,10,0]}
{"id":"12112","tokens":["The","STAT-1","signaling","pathway","provides","at","least","one","mechanism","for","activation","of","the","CAEV","LTR","by","IFN-gamma","in","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,9,0,7,0]}
{"id":"5028","tokens":["The","functional","Ets","binding","site","was","found","to","bind","Ets","family","proteins",",","principally","GA-binding","protein","and","Elf-1","and","could","be","transactivated","by","GABPalpha","and","-beta","synergistically","."],"ner_tags":[0,0,1,2,2,0,0,0,0,9,10,10,0,0,9,10,0,9,0,0,0,0,0,9,0,9,0,0]}
{"id":"13671","tokens":["Here","we","report","an","analysis","of","the","transcription","factor","families","AP-1",",","Sp1",",","NF-kappaB",",","and","signal","transducers","and","activators","of","transcription","(","STAT",")","in","cancer","patients","'","lymphocytes","before","and","after","IL-2","immunotherapy",",","as","assessed","by","a","gel-shift","assay","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,10,10,10,10,0,9,0,0,7,8,8,8,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"15978","tokens":["One","explanation","for","the","perpetuation","of","virus","infection","in","macrophages","could","be","sustained","nuclear","NF-kappa","B","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,0,0,0,0,9,10,0,0]}
{"id":"622","tokens":["However",",","this","deletion","mutation","prevented","the","induced","phosphorylation",",","degradative","loss",",","and","functional","release","of","I","kappa","B","alpha","from","NF-kappa","B","in","Tax-expressing","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,10,0,5,6,0]}
{"id":"9198","tokens":["We","detected","binding","for","the","EWS\/FLI-1","peptide","and","for","5","RAS","peptides","(","1","wild","type","and","4","mutated",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17393","tokens":["Two","abundant","proteins","of","75","and","80","kD","were","competed","out","by","poly","[","d","(","I-C",")","]","in","all","reactions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15835","tokens":["Transcription","of","the","hypersensitive","site","HS2","enhancer","in","erythroid","cells","."],"ner_tags":[0,0,0,1,2,2,2,0,7,8,0]}
{"id":"14267","tokens":["The","hypothesis","to","be","tested","was","whether","or","not","humans","exhibit","a","similar","susceptibility","to","PCDDs\/PCDFs","with","respect","to","the","surface","receptors","found","previously","to","respond","to","small","doses","of","2",",","3",",","7",",","8-tetrachlorodibenzo-p-dioxin","(","TCDD",")","in","Callithrix","jacchus","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5371","tokens":["We","analyzed","expression","of","AP-1",",","NF-kappa","B",",","NF-AT",",","and","octamer","binding","transcription","factors",",","which","are","known","to","be","involved","in","the","regulation","of","IL-2","gene","promoter","activity","."],"ner_tags":[0,0,0,0,9,0,9,10,0,9,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"4425","tokens":["Activated","Rac-1","could","mimic","activated","p21ras","to","induce","AP-1","but","not","to","induce","NFAT","."],"ner_tags":[9,10,0,0,9,10,0,0,9,0,0,0,0,9,0]}
{"id":"17060","tokens":["The","half-life","of","c-jun","RNA","as","determined","by","treating","HL-60","cells","with","TPA","and","actinomycin","D","was","30","min","."],"ner_tags":[0,0,0,3,4,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0]}
{"id":"5416","tokens":["Monocytic","cell","type-specific","transcriptional","induction","of","collagenase","."],"ner_tags":[0,0,0,0,0,0,9,0]}
{"id":"1264","tokens":["GIG10","is","a","novel","sequence","and","GIG18","is","the","mouse","homologue","of","a","human","expressed","sequence","tag","isolated","from","activated","B","lymphocytes","."],"ner_tags":[1,0,0,0,0,0,1,0,0,0,0,0,0,1,2,2,2,0,0,7,8,8,0]}
{"id":"14483","tokens":["However",",","a","hybrid","receptor","composed","of","the","extracellular","and","transmembrane","regions","of","the","human","type","II","interleukin-1","fused","to","the","cytoplasmic","domain","of","the","human","type","I","IL-1R","was","capable","of","transducing","a","signal","across","the","membrane","resulting","in","a","pattern","of","gene","activation","identical","to","that","mediated","by","the","type","I","IL-1R","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,0,0,9,10,10,10,0,0,0,9,10,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"3919","tokens":["However",",","this","factor","appeared","when","these","CML","patients","achieved","complete","haematological","remission","(","CHR",")","through","alpha-interferon","therapy","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"12233","tokens":["We","show","that","the","transcription","factor","NFATc","was","sufficient","as","a","cellular","factor","to","induce","a","highly","permissive","state","for","HIV-1","replication","in","primary","CD4+","T","cells","."],"ner_tags":[0,0,0,0,9,10,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"9465","tokens":["Considering","that","nuclear","regulatory","factor-kappa","beta","(","NF-kappa","B",")","\/Rel","is","a","common","regulatory","element","of","the","promoter","region","of","the","inflammatory","cytokine","genes",",","herein",",","we","tested","the","hypothesis","that","acute","ethanol","affects","NF-kappa","B","activation","in","human","monocytes","."],"ner_tags":[0,0,9,10,10,10,9,10,10,10,10,0,0,0,9,10,0,0,1,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,7,8,0]}
{"id":"8395","tokens":["HMG-I","(","Y",")","also","binds","to","a","second","oligonucleotide","containing","a","BP1","binding","site","located","in","a","negative","control","region","upstream","of","the","delta-globin","gene",",","suggesting","a","role","for","HMG-I","(","Y",")","in","repression","of","adult","globin","genes","."],"ner_tags":[9,10,10,10,0,0,0,0,0,0,0,0,1,2,2,0,0,0,1,2,2,0,0,0,1,2,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0]}
{"id":"15993","tokens":["All","three","cell","lines","expressed","vitamin","D","receptor","and","had","increased","levels","of","IL-1","beta","mRNA","in","response","to","LPS","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,4,0,0,0,0,0]}
{"id":"5983","tokens":["This","peptide","potently","inhibited","NFAT","activation","and","NFAT","-dependent","expression","of","endogenous","cytokine","genes","in","T","cells",",","without","affecting","the","expression","of","other","cytokines","that","require","calcineurin","but","not","NFAT","."],"ner_tags":[0,0,0,0,9,0,0,9,0,0,0,1,2,2,0,7,8,0,0,0,0,0,0,0,9,0,0,9,0,0,9,0]}
{"id":"11324","tokens":["Suppression","by","azelastine","hydrochloride","of","NF-kappa","B","activation","involved","in","generation","of","cytokines","and","nitric","oxide","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,9,0,0,0,0]}
{"id":"4868","tokens":["Transcriptional","activation","of","RNA","polymerase","III-dependent","genes","by","the","human","T-cell","leukemia","virus","type","1","tax","protein","."],"ner_tags":[0,0,0,1,2,2,2,0,0,9,10,10,10,10,10,10,10,0]}
{"id":"7372","tokens":["Using","electrophoretic","mobility","shift","assays","and","supershift","assays","we","demonstrate","that","this","region","is","specifically","bound","by","Sp1","and","AP-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"12652","tokens":["Nuclear","factor-kappa","B","activity","in","T","cells","from","patients","with","rheumatic","diseases",":","a","preliminary","report","."],"ner_tags":[9,10,10,0,0,7,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"2335","tokens":["1","alpha",",","25-","(","OH",")","2D3","inhibited","CD23","expression","in","U937","cells",",","yet","failed","to","modulate","CD23","expression","in","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,5,6,0,0,0,0,0,9,0,0,7,8,0]}
{"id":"9353","tokens":["These","studies","indicate","that","A-myb","plays","a","role","during","a","narrow","window","of","normal","B","cell","differentiation","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,8,0,0]}
{"id":"10264","tokens":["Moreover",",","a","CIITA","protein","in","which","both","functional","alpha-helices","have","been","deleted","displays","a","dominant","negative","phenotype","."],"ner_tags":[0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"17288","tokens":["This","result","suggests","that","two","catalytically","similar","proteins",",","cyclophilin","and","FKBP",",","evolved","independently","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0]}
{"id":"8359","tokens":["While","Rel","proteins","play","the","dominant","role","in","RANTES","gene","expression","in","fibroblasts",",","RFLAT-1","is","a","strong","transactivator","for","RANTES","in","T","cells","."],"ner_tags":[0,9,10,0,0,0,0,0,1,2,0,0,0,0,9,0,0,0,0,0,9,0,7,8,0]}
{"id":"2133","tokens":["Tat","transactivation","mediated","by","the","kappa","B","domain","is","sufficient","to","allow","replication","of","TAR","-deleted","mutant","HIV-1","in","astrocytes","."],"ner_tags":[9,0,0,0,0,1,2,2,0,0,0,0,0,0,1,0,0,0,0,7,0]}
{"id":"10608","tokens":["This","activation","is","inhibited","by","known","inhibitors","of","NF-kappa","B","or","by","simultaneous","treatment","of","the","cells","with","surfactant","lipids","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4838","tokens":["During","T-cell","activation",",","c-myb","expression","is","induced","and","much","of","the","increase","in","expression","occurs","at","the","transcriptional","level","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7324","tokens":["In","this","review",",","we","summarize","our","current","understanding","of","the","transcriptional","regulation","of","T","cell","development","and","function","with","particular","emphasis","on","the","results","of","recent","gene","targeting","and","transgenic","experiments","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13050","tokens":["Our","data","suggest","that","CD30","critically","regulates","the","CD40","-mediated","differentiation","of","non-antigen-selected","human","B","cells","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,0,0,5,6,6,6,0]}
{"id":"17479","tokens":["The","addition","of","1.4","nM","aldosterone","did","not","prevent","this","loss","of","electrolytes","as","observed","in","normal","persons","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9147","tokens":["IL-8","is","secreted","in","response","to","inflammatory","stimuli",",","notably","bacterial","products","such","as","lipopolysaccharide","(","LPS",")",",","but","little","is","known","about","the","mechanisms","by","which","these","agents","mediate","IL-8","induction","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"2435","tokens":["Most","cells","infected","with","hRAR","alpha","exhibited","promyelocytic","morphology","and","were","thought","to","be","blocked","at","the","promyelocytic","stage","in","their","myeloid","differentiation","."],"ner_tags":[0,0,0,0,9,10,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1427","tokens":["Thus",",","PKC-zeta","overexpression","stimulates","a","type","of","phenotypic","differentiation","that","differs","significantly","from","maturation","occurring","upon","activation","of","other","PKC","subfamilies","induced","by","phorbol","ester","treatment","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"581","tokens":["The","reactivity","of","T","cell","lines","in","different","groups","reflected","a","pattern","similar","to","PBMC","after","treatment","."],"ner_tags":[0,0,0,5,6,6,0,0,0,0,0,0,0,0,7,0,0,0]}
{"id":"3731","tokens":["To","further","reduce","the","size","of","the","common","deleted","region","we","have","searched","for","small","deletions","or","mitotic","recombination","events",",","neither","of","which","would","be","detected","by","conventional","cytogenetics","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15334","tokens":["Phorbol","esters","are","required","to","induce","AIM\/CD69","cell-surface","expression","as","well","as","for","triggering","the","proliferation","of","T","cells","in","conjunction","with","anti-AIM","mAb","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,9,10,0]}
{"id":"14430","tokens":["Together",",","these","results","show","that","NF-kappa","B","controls","the","expression","of","I","kappa","B","alpha","by","means","of","an","inducible","autoregulatory","pathway","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0]}
{"id":"11778","tokens":["The","tax","gene","product","of","the","type","I","human","T-cell","leukemia","virus","(","HTLV-I",")","transactivates","interleukin-2","(","IL-2",")","gene","through","activation","of","an","enhancer","termed","CD28","responsive","element","(","CD28RE",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,0,0,1,2,2,0,1,0,0]}
{"id":"11073","tokens":["These","studies","have","indicated","that","the","individual","repeats","are","not","identical","with","respect","to","the","cellular","factors","with","which","they","interact","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"6598","tokens":["We","demonstrate","here","that","beta-catenin","can","be","imported","into","the","nucleus","independently","of","LEF\/TCF","binding",",","and","it","may","also","be","exported","from","nuclei","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10155","tokens":["CONCLUSIONS",":","Our","results","show","that","glucocorticoids","at","clinically","relevant","concentrations","exert","specific","actions","on","expression","of","adhesion","molecules","on","activated","neutrophils",",","which","are","mediated","through","ligation","of","glucocorticoid","receptors","and","induction","of","protein","synthesis",",","and","suggest","a","novel","mechanism","by","which","anti-inflammatory","corticosteroids","may","inhibit","leukocyte","accumulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,8,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7066","tokens":["Recent","studies","have","shown","that","the","non-steroidal","anti-inflammatory","drugs","(","NSAIDs",")","activate","heat","shock","transcription","factor","(","HSF1",")","from","a","latent","cytoplasmic","form","to","a","nuclear",",","DNA","binding","state","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0,0,9,10,10,0,0,9,10,10,10,10,0]}
{"id":"9749","tokens":["Thus",",","Egr-1","seems","to","control","the","expression","of","downstream","target","genes","not","only","as","a","transcriptional","activator",",","but","also","as","a","repressor","molecule","."],"ner_tags":[0,0,9,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"8029","tokens":["Most","mutations","were","outside","the","motifs","potentially","important","for","transcription",",","suggesting","they","were","not","important","in","lymphomagenesis","but","may",",","like","Ig","mutation",",","represent","an","inherent","feature","of","the","lymphoma","precursor","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"6576","tokens":["Thus",",","IkappaB-alphaS32\/36A","offers","proof-of-principle","that","artifactually","gained","functions",",","when","used","to","attenuate","the","replication","of","live","HIV-1",",","can","be","stable","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1846","tokens":["The","strong","induction","of","HIV","expression","by","NaB","or","HMBA","in","J","delta","K","cells","clearly","demonstrates","the","existence","of","NF-kappa","B","-independent","mechanisms","of","HIV","activation","in","chronically","infected","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,9,10,0,0,0,0,0,0,7,8,8,0]}
{"id":"1397","tokens":["The","TCL1","locus","on","chromosome","14q32.1","is","frequently","involved","in","chromosomal","translocations","and","inversions","with","one","of","the","T-cell","receptor","loci","in","human","T-cell","leukemias","and","lymphomas","."],"ner_tags":[0,1,2,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0]}
{"id":"4371","tokens":["The","IFN","-dependent","increase","in","RAR","(","alpha",")","levels","and","the","enhancing","effect","of","the","cytokine","on","retinoid-dependent","granulocytic","markers","expression","may","be","a","characteristic","of","PML-RAR","positive","cells",",","since","the","phenomena","are","not","observed","in","HL-60","promyelocytes","."],"ner_tags":[0,9,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,0,9,10,10,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"515","tokens":["Human","MHC","class","II","gene","transcription","directed","by","the","carboxyl","terminus","of","CIITA",",","one","of","the","defective","genes","in","type","II","MHC","combined","immune","deficiency","."],"ner_tags":[0,1,2,2,2,0,0,0,0,9,10,0,1,0,0,0,0,1,2,0,0,0,9,0,0,0,0]}
{"id":"7270","tokens":["Single-cell","reverse","transcriptase","-polymerase","chain","reaction","(","RT-PCR",")","analysis","was","applied","to","this","culture","system","to","investigate","gene","expression","of","diverse","receptors",",","markers","of","differentiation",",","and","transcription","factors","(","EKLF",",","GATA-1",",","GATA-2",",","p45","NF-E2",",","PU.1",",","and","SCL\/Tal1",")","at","discrete","stages","of","erythropoietic","development","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,10,0,0,9,10,0,9,0,9,0,9,0,9,10,0,9,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"7087","tokens":["To","understand","the","action","of","FGF-1","in","T","cells",",","studies","were","initiated","in","Jurkat","T","cells","that","express","the","signaling","isoform","of","FGF","receptor-1","."],"ner_tags":[0,0,0,0,0,9,0,7,8,0,0,0,0,0,5,6,6,0,0,0,0,0,0,9,10,0]}
{"id":"2854","tokens":["The","0.2-kb","IRF-CAT","construct","was","induced","by","PRL","stimulation","during","the","G1","phase","of","the","cell","cycle","."],"ner_tags":[0,0,1,2,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"15754","tokens":["Finally",",","TPA","addition","to","monocytes","infected","with","HIV-1","inhibited","HIV-1","replication",",","as","determined","by","reverse","transcriptase","assays",",","in","a","concentration-dependent","manner","."],"ner_tags":[0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"1720","tokens":["The","severe","phenotype","of","females","with","tiny","ring","X","chromosomes","is","associated","with","inability","of","these","chromosomes","to","undergo","X","inactivation","."],"ner_tags":[0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,1,0,0,0,0,0]}
{"id":"14035","tokens":["Amplified","cDNA","were","sequenced","by","standard","methods","."],"ner_tags":[0,1,0,0,0,0,0,0]}
{"id":"6766","tokens":["Messenger","RNA","production","coding","for","IL-8",",","RANTES",",","and","MCP-1","showed","parallel","variations","to","the","production","of","the","correspondent","proteins","."],"ner_tags":[3,4,0,0,0,9,0,9,0,0,9,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"5973","tokens":["Gene","transcription","through","activation","of","G-protein-coupled","chemoattractant","receptors","."],"ner_tags":[0,0,0,0,0,9,10,10,0]}
{"id":"4511","tokens":["Basal","total","white","blood","cell","and","granulocyte","counts","did","not","appreciably","differ","between","PML\/RARalpha","transgenic","and","control","mice","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"15512","tokens":["Thus",",","the","DRA","promoter","discriminates","against","OTF-1","activation","at","the","level","of","DNA","binding","in","the","glioblastoma","line","."],"ner_tags":[0,0,0,1,2,0,0,9,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"1646","tokens":["This","is","the","first","report","of","a","physical","interaction","between","an","Ets","family","member","and","NF-kappa","B","family","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"14633","tokens":["Comparison","of","the","derived","protein","sequence","with","those","of","rodent","homologs","allows","classification","into","three","groups","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"436","tokens":["IL-2","-mediated","T","cell","proliferation","is","a","critical","early","event","in","the","inflammatory","process","."],"ner_tags":[9,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6032","tokens":["Both","the","mutant","and","wild-type","strains","were","more","resistant","to","stress","when","in","stationary","phase","than","when","in","the","logarithmic","phase","of","growth","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2874","tokens":["Overexpression","of","full-length","SCL","protein","in","the","lymphoid","cell","lines",",","SupT1","and","Raji",",","did","not","alter","cell","phenotype","and","there","was","no","evidence","for","autoregulation","of","SCL","transcription","."],"ner_tags":[0,0,0,9,10,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"5236","tokens":["Therefore",",","the","surprisingly","high","replicative","capacity","of","NF-kappaB","and","Sp1","binding","site","mutants","of","SIVmac","is","due","to","unique","features","or","the","enhancer\/promoter","region","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"9014","tokens":["Interleukin-10","inhibits","expression","of","both","interferon","alpha-","and","interferon","gamma-","induced","genes","by","suppressing","tyrosine","phosphorylation","of","STAT1","."],"ner_tags":[9,0,0,0,0,1,2,2,2,2,2,2,0,0,0,0,0,9,0]}
{"id":"1904","tokens":["We","examined","whether","NF","(","P",")",",","a","nuclear","factor","specific","for","the","P","sequence",",","is","related","to","NF-kappa","B","and","NF-AT","."],"ner_tags":[0,0,0,9,10,10,10,0,0,9,10,0,0,0,1,2,0,0,0,0,9,10,0,9,0]}
{"id":"16525","tokens":["The","B2","factor","was","induced","in","the","nuclei","of","these","cells","only","upon","HIV1","infection","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5691","tokens":["A","nucleotide","substitution","within","a","recently","described","OAP40","element","located","just","upstream","of","an","NF-AT","site","(","P","sequence",")","appears","to","be","largely","responsible","for","the","increased","promotor","strength","of","this","particular","allelic","form","of","the","IL-4","promoter","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,0,1,2,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"11554","tokens":["Human","immunodeficiency","virus-type","1","(","HIV-1",")","infection","is","characterized","by","a","chronic","state","of","immune","hyperactivation","in","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10323","tokens":["Induction","of","human","immunodeficiency","virus","type","1","expression","in","monocytic","cells","by","Cryptococcus","neoformans","and","Candida","albicans","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"2257","tokens":["CD38","is","a","leukocyte","differentiation","antigen","that","has","been","thought","to","be","a","phenotypic","marker","of","different","subpopulations","of","T-","and","B-","lymphocytes","."],"ner_tags":[9,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"8811","tokens":["Precursor","frequency","of","anti-SSB","T","cells","was","1",":","77",",","040","and","1",":","115",",","000","in","2","healthy","subjects","and","1",":","230",",","250","and","1",":","103",",","034","in","two","patients","with","SS","."],"ner_tags":[0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17124","tokens":["Its","expression","appears","to","be","activated","during","pro-B-cell","development",",","is","abundant","at","the","pre-B-","and","mature","B-cell","stages",",","but","is","absent","in","terminally","differentiated","plasma","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"17413","tokens":["Furthermore",",","we","did","not","observe","any","qualitative","differences","between","the","effect","of","cyclosporin","A","and","FK506","on","six","different","transcription","factors","which","suggests","that","these","drugs","may","interfere","with","the","activity","of","a","novel","Ca2+","dependent","step","that","regulates","several","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"12727","tokens":["Subsequently",",","a","1.8","kilobase","(","kb",")","fragment","of","the","CIITA","promoter","was","isolated","and","sequenced","."],"ner_tags":[0,0,0,1,2,2,2,2,2,0,0,1,2,0,0,0,0,0]}
{"id":"11496","tokens":["However",",","little","is","known","about","negative","regulation","of","IL-1beta","expression","at","the","transcriptional","level",",","which","may","play","an","important","role","in","anti-inflammatory","and","immunosuppressive","effects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6772","tokens":["Several","new",",","clinically","relevant","compounds","dissociate","antiproliferative","and","calcemic","activities","of","1",",","25","(","OH",")","2D3",",","but","the","molecular","basis","for","this","has","not","been","clearly","elucidated","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"110","tokens":["The","role","of","p95vav","in","TCR","-mediated","signaling","processes","is","unclear","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,0]}
{"id":"1963","tokens":["The","NM23","gene","has","been","proposed","as","a","metastasis-suppressor","gene",",","and","its","use","has","been","suggested","as","prognostic","factor","."],"ner_tags":[0,1,2,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5037","tokens":["Antibodies","to","Stat6","detected","a","unique","band","in","macaque","cell","lysates","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"14334","tokens":["Stimulation","of","highly","purified","human","T-cells","via","CD2","and","CD28","adhesion","molecules","induces","and","maintains","proliferation","for","more","than","3","weeks","."],"ner_tags":[0,0,7,8,8,8,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"4152","tokens":["A","major","obstacle","in","understanding","the","signaling","events","that","follow","CD28","receptor","ligation","arises","from","the","fact","that","CD28","acts","as","a","costimulus","to","TCR","engagement",",","making","it","difficult","to","assess","the","relative","contribution","of","CD28","signals","as","distinct","from","those","of","the","TCR","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"11165","tokens":["The","foregoing","data",",","as","well","as","the","requirement","of","catalytically","active","NE","to","trigger","alphaIIbbeta3","activation","and","potentiate","threshold","of","cathepsin","G","-initiated","platelet","aggregation",",","led","us","to","examine","whether","the","structure","of","this","integrin","was","affected","by","NE","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,0]}
{"id":"4089","tokens":["The","human","tumor","necrosis","factor","alpha","(","TNF-alpha",")","gene","is","one","of","the","earliest","genes","transcribed","after","the","stimulation","of","a","B","cell","through","its","antigen","receptor","or","via","the","CD-40","pathway","."],"ner_tags":[0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,9,10,0,0,0,0,0,0]}
{"id":"17861","tokens":["Searching","of","B4-2","DNA","and","protein","sequences","against","various","databases","revealed","no","high","homology","to","other","sequences","."],"ner_tags":[0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2259","tokens":["Virtually","no","information","is","available","on","regulation","and","functions","of","CD38","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"14893","tokens":["The","results","suggest","that","there","exists","a","functional","antagonism","between","VitD3","and","RA","that","may","have","important","implications","for","the","regulation","of","certain","immune","and","inflammatory","responses","through","their","inverse","effects","on","CD14","and","CD23","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"770","tokens":["Large","amounts","of","viral","RNA","and","particles","were","synthesized","in","infections","established","using","the","tat","mutants","that","contain","modified","LTRs","."],"ner_tags":[0,0,0,3,4,0,0,0,0,0,0,0,0,0,9,10,0,0,1,2,0]}
{"id":"2368","tokens":["Androgen","binding","sites","have","been","identified","in","circulating","human","mononuclear","leukocytes","of","healthy","donors","of","both","sexes","."],"ner_tags":[9,10,10,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0]}
{"id":"17798","tokens":["We","investigated","here","the","question","of","the","regulation","of","platelet","Ca","(","2+",")","-ATPases","by","cyclic","AMP","through","the","phosphorylation","of","the","Rap1","protein","using","a","pathological","model","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"13955","tokens":["Isoelectric","focusing","demonstrated","that","TPO","induced","fetal","and","adult","Hb","synthesis",",","whereas","EPO","induced","embryonic",",","fetal",",","and","adult","Hb","synthesis","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"14085","tokens":["To","gain","a","better","understanding","of","the","impact","of","long","terminal","repeat","(","LTR",")","sequence","diversity","on","LTR-directed","gene","expression","in","cells","of","the","central","nervous","system","(","CNS",")","and","immune","system",",","we","amplified","and","cloned","LTRs","from","proviral","DNA","in","HIV-1-infected","peripheral","blood","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,0,1,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,2,0,7,8,8,0]}
{"id":"5761","tokens":["We","investigated","whether","the","inability","to","maintain","EBV-positive","NPC","cell","lines","in","culture","was","related","to","Qp","activity","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,1,0,0]}
{"id":"8920","tokens":["Treatment","of","T","lymphocytes","with","IFN-alpha",",","IL-2",",","IL-12",",","and","IL-15","upregulated","IL-2Ralpha",",","c-myc",",","and","pim-1","gene","expression","."],"ner_tags":[0,0,7,8,0,9,0,9,0,9,0,0,9,0,9,0,1,0,0,1,2,0,0]}
{"id":"7483","tokens":["Synthesis","and","biological","evaluation","of","the","first","dicarba-closo-dodecaborane","(","carborane",")","derivatives","of","retinoids","are","described","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1280","tokens":["Effects","of","intranasal","glucocorticoids","on","endogenous","glucocorticoid","peripheral","and","central","function","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2674","tokens":["These","results","indicate","that","RA","directly","inhibits","the","erythroid","differentiation","program","at","the","level","of","early","adult","HPC",",","and","may","lead","to","a","shift","from","the","erythroid","to","granulocytic","differentiation","pathway","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5992","tokens":["Expression","of","PPARgamma",",","a","heterodimer","partner","of","RXR",",","is","also","markedly","induced","by","RA","in","THP-1","cells","."],"ner_tags":[0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"5859","tokens":["The","peroxisome-proliferator","activated","receptor","gamma","(","PPARgamma",")",",","a","member","of","the","nuclear","receptor","superfamily","of","ligand","activated","transcription","factors",",","plays","a","key","role","in","the","anti-diabetic","actions","of","the","thiazolidinediones","(","TZDs",")","."],"ner_tags":[0,9,10,10,10,0,9,0,0,0,0,0,0,9,10,10,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6784","tokens":["Overexpression","of","SLP-76","in","the","Jurkat","T","cell","line","potentiates","the","activities","of","both","nuclear","factor","of","activated","T","cells","and","AP-1","transcription","factors","."],"ner_tags":[0,0,9,0,0,5,6,6,6,0,0,0,0,0,9,10,10,10,10,10,0,9,10,10,0]}
{"id":"4420","tokens":["Expression","of","dominant","negative","MAPKK-1","prevents","NFAT","induction","."],"ner_tags":[0,0,9,10,10,0,9,0,0]}
{"id":"7406","tokens":["We","have","used","this","DNA","fragment","to","isolate","and","purify","a","60-kDa","protein","binding","to","this","fragment","and","obtained","its","amino-terminal","sequence",",","which","was","used","to","design","degenerate","probes","to","screen","a","cDNA","library","from","THP-1","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,1,2,0,0,0,0,0,0,5,6,0]}
{"id":"78","tokens":["Several","recent","studies","have","implicated","Jak","kinases","in","the","signaling","pathway","induced","by","IL-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"9999","tokens":["NF-kappa","B","was","examined","as","one","of","the","many","molecular","mechanisms","for","mediating","cell","death","by","MTBE","and","benzene","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10992","tokens":["CsA","does","not","interfere","with","the","synthesis","of","Rel","proteins",",","but","prevents","the","inducible","degradation","of","cytosolic","NF-kappa","B","inhibitors","I","kappa","B","alpha","and","I","kappa","B","beta","upon","T","cell","activation","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,9,10,10,10,9,10,10,10,0,9,10,10,10,0,0,0,0,0]}
{"id":"16119","tokens":["Using","Western","blot","analysis","with","a","monoclonal","antibody","recognizing","a","17-amino","acid","epitope","of","the","1",",","25-dihydroxyvitamin","D3","[","1",",","25","(","OH",")","2D3","]","receptor",",","we","have","detected","two","crossreacting","proteins","in","activated","normal","human","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,9,10,10,0,0,9,10,10,10,10,10,10,10,10,10,10,10,10,10,0,0,0,0,0,9,10,0,7,8,8,8,0]}
{"id":"16098","tokens":["The","results","showed","that","the","activation","of","U2","snRNA","transcription","in","B-cells","also","requires","an","enhancer","comprising","both","the","Oct","and","at","least","one","Sp","1-binding","site","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,1,0,0,0,0,1,2,2,0]}
{"id":"13057","tokens":["Are","there","effects","of","CyA","and","FK","506","all","attributable","to","CN","inhibition",",","and","how","much","of","them","are","mediated","through","the","NFATC","family","of","transcription","factors","?"],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0]}
{"id":"4930","tokens":["Here","we","summarize","studies","which","investigate","the","mechanism","by","which","these","cytokines","selectively","reprogramme","gene","expression","in","T-lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,7,0]}
{"id":"7746","tokens":["The","results","show","that","IFN-alpha","can","induce","MAPK","activity",",","but","only","in","cells","containing","Lck","."],"ner_tags":[0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"9284","tokens":["To","characterize","the","role","of","these","P-like","elements","and","their","binding","factors","in","the","native","promoter",",","we","did","transient","transfection","and","electrophoretic","mobility","shift","assays","(","EMSA",")","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,9,10,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8790","tokens":["Therefore",",","the","high","radiosensitivity","of","squamous","cell","carcinomas","in","our","samples","could","be","explained","by","an","overexpression","of","c-fos","in","the","tumor-infiltrating","lymphocytes","induced","by","small","doses","of","radiation","therapy",",","and","these","activated","lymphocytes","exerted","a","cytotoxic","effect","against","the","cancer","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,7,8,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,7,8,0]}
{"id":"94","tokens":["Interferon-gamma","(","IFN-gamma",")","is","an","important","immunoregulatory","protein","produced","predominantly","by","T","cells","and","large","granular","lymphocytes","(","LGL",")","in","response","to","different","extracellular","signals","."],"ner_tags":[9,0,9,0,0,0,0,9,10,0,0,0,7,8,0,7,8,8,0,7,0,0,0,0,0,0,0,0]}
{"id":"982","tokens":["Furthermore",",","transcripts","of","PEBP2","alpha","A","and","mouse","AML1\/PEBP2","alpha","B","were","detected","in","T","lymphocytes","in","the","thymuses","from","day","16","embryos","and","newborns",",","as","well","as","4-week-old","adult","mice",",","by","in","situ","hybridization","."],"ner_tags":[0,0,0,0,9,10,10,0,9,10,10,10,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13631","tokens":["The","pathological","alteration","of","this","cytokine","pathway","leading","to","NF-kappaB","activation","by","Tax","may","play","a","central","role","in","HTLV-1-mediated","transformation","of","human","T","cells",",","clinically","manifested","as","the","adult","T-cell","leukemia"],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0]}
{"id":"1371","tokens":["Epstein-Barr","virus","(","EBV",")","infection","of","mature",",","resting","B","cells","drives","them","to","become","lymphoblasts","expressing","high","levels","of","cell","surface","molecules",",","such","as","CD48",",","characteristically","expressed","on","normal","activated","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,7,8,8,8,0]}
{"id":"13632","tokens":["Role","of","IKK1","and","IKK2","in","lipopolysaccharide","signaling","in","human","monocytic","cells","."],"ner_tags":[0,0,9,0,9,0,0,0,0,7,8,8,0]}
{"id":"17568","tokens":["Expression","cloning","of","c-Jun","."],"ner_tags":[0,0,0,9,0]}
{"id":"18321","tokens":["Results","similar","to","those","observed","with","U-937","cells","were","also","obtained","with","human","peripheral","blood","monocytes","."],"ner_tags":[0,0,0,0,0,0,5,6,0,0,0,0,7,8,8,8,0]}
{"id":"7380","tokens":["We","hypothesized","that","inhibition","of","either","PKC","or","PTK","would","decrease","LPS-induced","NF-kappaB","DNA","binding","and","TNF-alpha","release","in","human","monocytes","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,9,0,0,0,9,0,0,7,8,0]}
{"id":"12854","tokens":["Thirty","percent","of","GC","B","cells",",","but","not","naive","B","cells",",","displayed","mutations","in","the","742","bp","region","analyzed","within","the","first","intron","of","BCL-6","(","overall","frequency",":","5","x","10","(","-4",")","\/bp",")","."],"ner_tags":[0,0,0,7,8,8,0,0,0,7,8,8,0,0,0,0,0,1,2,2,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16244","tokens":["The","murine","and","human","factors","are","abundantly","expressed","in","a","variety","of","human","and","murine","T-cell","lines","and","can","activate","transcription","through","a","tissue-specific","GATA-binding","site","identified","within","the","human","T-cell","receptor","delta","gene","enhancer","."],"ner_tags":[0,9,10,10,10,0,0,0,0,0,0,0,5,6,6,6,6,0,0,0,0,0,0,1,2,2,0,0,0,1,2,2,2,2,2,0]}
{"id":"5174","tokens":["Such","repressive","function","is","similar","to","that","seen","in","IRF-2","or","ICSBP","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"1078","tokens":["In","HIV-infected","cells",",","I","kappa","B","alpha","protein","levels","are","decreased","secondary","to","enhanced","protein","degradation","."],"ner_tags":[0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"18036","tokens":["The","human","TCF-1","gene","encodes","a","nuclear","DNA-binding","protein","uniquely","expressed","in","normal","and","neoplastic","T-lineage","lymphocytes","."],"ner_tags":[0,1,2,2,0,0,9,10,10,0,0,0,5,6,6,6,6,0]}
{"id":"3759","tokens":["Activation","of","TGF-beta","2","transcription","correlates","with","the","loss","of","binding","activity","for","an","80","kDA","glial","labile","repressor","protein",",","GLRP",",","to","a","responsive","region","within","the","TFG-beta","2","promoter","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,9,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"9566","tokens":["IL-2","and","T","cell","antigen","receptor","complex","induction","of","STAT3alpha","serine","727","phosphorylation","is","dependent","on","the","activity","of","the","MEK","\/ERK","pathway","."],"ner_tags":[9,0,9,10,10,10,10,0,0,9,0,0,0,0,0,0,0,0,0,0,9,9,0,0]}
{"id":"111","tokens":["Here",",","we","show","that","overexpression","of","p95vav","alone","in","Jurkat","T","cells","leads","to","activation","of","the","nuclear","factors",",","including","NFAT",",","involved","in","interleukin-2","expression","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,7,8,0,0,0,0,0,9,10,0,0,9,0,0,0,9,0,0]}
{"id":"1011","tokens":["There","was","no","significant","effect","of","BDP","on","IL-1","and","tumour","necrosis","factor","alpha","(","TNF","alpha",")","-induced","changes","of","gcRs","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,10,10,10,0,9,10,0,0,0,0,9,0]}
{"id":"8832","tokens":["Methylation","of","HpaII","and","Hha","I","sites","near","the","polymorphic","trinucleotide","repeat","of","the","human","androgen","receptor","gene","(","HUMARA",")","has","been","shown","to","correlate","with","X-inactivation","."],"ner_tags":[0,0,1,2,2,2,2,0,0,1,2,2,0,0,1,2,2,2,0,1,0,0,0,0,0,0,0,0,0]}
{"id":"6011","tokens":["Retention","of","the","normal","BRCA1","allele","in","the","tumor","with","the","heterozygous","germline","BRCA1","mutation",",","2418delA",",","indicated","that","mutational","inactivation","of","both","BRCA1","alleles","was","not","required","for","tumorigenesis","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0]}
{"id":"3439","tokens":["The","induction","of","immediate-early","(","IE",")","response","genes",",","such","as","egr-1",",","c-fos",",","and","c-jun",",","occurs","rapidly","after","the","activation","of","T","lymphocytes","."],"ner_tags":[0,0,0,1,2,2,2,2,2,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,7,8,0]}
{"id":"18140","tokens":["Complex","1","results","from","binding","of","a","ubiquitous","polypeptide","that","recognizes","the","3","'","portion","of","this","sequence","and","is","not","required","for","repression","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"3199","tokens":["IL-2R","alpha","is","rapidly","and","potently","induced","in","T","cells","in","response","to","mitogenic","stimuli","."],"ner_tags":[9,10,0,0,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"4671","tokens":["Structural","and","functional","characterization","of","the","human","CD36","gene","promoter",":","identification","of","a","proximal","PEBP2\/CBF","site","."],"ner_tags":[0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,1,2,0]}
{"id":"16320","tokens":["A","potentially","more","common","pharmacogenetic","syndrome","."],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"1735","tokens":["Whereas","anti-CD28","together","with","PMA","increased","the","DNA","binding","and","trans-activation","activity","of","NF-kappa","B",",","PMA-induced","activation","of","AP-1","was","significantly","suppressed","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,9,0,0,0,0]}
{"id":"500","tokens":["The","generation","of","second","messengers","in","T","cells","normally","leads","to","downstream","signaling","that","results","in","transcriptional","activation","of","the","IL-2","gene","."],"ner_tags":[0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"14849","tokens":["Costimulation","of","cAMP","and","protein","kinase","C","pathways","inhibits","the","CD3","-dependent","T","cell","activation","and","leads","to","a","persistent","expression","of","the","AP-1","transcription","factor","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"10454","tokens":["Functional","IL-12","is","a","heterodimer","composed","of","two","distinct","subunits","that","are","encoded","by","separate","genes","on","different","chromosomes","."],"ner_tags":[0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10356","tokens":["Both","cytokines","are","able","to","stimulate","cell","proliferation",",","differentiation",",","and","survival","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13503","tokens":["These","data","demonstrate","that","the","15-amino","acid","sequence","of","NFATx1","is","a","major","transactivation","sequence","required","for","induction","of","genes","by","NFATx1","in","T","cells","and","possibly","regulates","NFAT","activity","through","tissue-specific","alternative","splicing","."],"ner_tags":[0,0,0,0,0,9,10,10,0,9,0,0,9,10,10,0,0,0,0,0,0,9,0,7,8,0,0,0,9,0,0,0,0,0,0]}
{"id":"7747","tokens":["Furthermore",",","STATs1","and","-3","are","effectively","phosphorylated","and","activated","to","bind","DNA","in","the","absence","of","Lck","expression","in","IFN-alpha-treated","cells","."],"ner_tags":[0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,5,6,0]}
{"id":"4218","tokens":["Interleukin-7","(","IL-7",")","stimulates","the","proliferation","of","normal","and","leukemic","B","and","T","cell","precursors","and","T","lymphocytes","."],"ner_tags":[9,0,9,0,0,0,0,0,7,8,8,8,8,8,8,8,8,8,8,0]}
{"id":"10343","tokens":["Two","families","of","transcription","factors","that","are","required","for","normal","hematopoiesis","are","c-Myb","and","Ets","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"10291","tokens":["After","its","associated","proteins",",","especially","the","heat-shock","protein","hsp90",",","had","been","cross-linked","with","the","hMR","by","dimethylpimelimidate",",","18C7","was","still","able","to","react","with","the","receptor","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"767","tokens":["To","test","these","hypotheses",",","we","studied","several","tat","mutants",",","including","two","stop","codon","mutants","and","one","deletion","mutant","using","replication-competent","HIV-1","constructs","carrying","wild-type","or","mutant","LTRs","with","modifications","in","the","NF-kappa","B","and\/or","Sp1","binding","sites","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,0,0,9,10,0,1,2,2,0,1,2,2,2,0,0,0,0,1,2,2,2,2,2,0]}
{"id":"5128","tokens":["DNA-binding","phosphoproteins","induced","after","T","cell","activation",":","effects","of","cyclosporin","A","."],"ner_tags":[9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15961","tokens":["In","vitro","translated","MAD-3","protein","was","found","to","specifically","inhibit","the","DNA-binding","activity","of","the","p50\/p65","NF-kappa","B","complex","but","not","that","of","the","p50\/p50","KBF1","factor","or","of","other","DNA-binding","proteins","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,9,10,10,0,0,0,9,10,0]}
{"id":"824","tokens":["This","protein",",","previously","identified","by","its","binding","to","the","Ig","kappa","3","'","enhancer","and","the","Ig","heavy","chain","mu","E1","site",",","thus","also","appears","to","be","quite","important","in","the","regulation","of","MHC","class","II","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0]}
{"id":"14816","tokens":["However",",","the","phosphorylation","of","the","precursor","interleukin-1","alpha","cytokine","was","increased","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,0,0,0]}
{"id":"2336","tokens":["Furthermore",",","1","alpha",",","25-","(","OH",")","2D3","induced","24-hydroxylase","mRNA","expression","and","metabolic","activity","in","both","U937","cells","and","lectin-activated","T","cells",",","yet","failed","to","induce","24-hydroxylase","mRNA","or","its","metabolic","activity","in","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,5,6,0,7,8,8,0,0,0,0,0,3,4,0,0,0,0,0,7,8,0]}
{"id":"7357","tokens":["In","addition",",","we","demonstrate","that","NF-kappaB","may","be","required","for","human","CD34","(","+",")","bone","marrow","cell","clonogenic","function","and","survival","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,7,8,8,8,8,8,8,0,0,0,0,0]}
{"id":"3464","tokens":["The","effect","of","DM","on","expression","of","IL-2R","alpha","(","Tac",",","p55",",","CD25",")","and","beta","(","p75",")","genes","in","activated","T","cells","was","examined","next","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,9,0,9,0,9,0,0,1,2,2,2,2,0,7,8,8,0,0,0,0]}
{"id":"1603","tokens":["Electrophoretic","mobility-shift","assays","(","EMSA",")","showed","that","individual","DR","units",",","as","well","as","the","12-bp","insert",",","can","bind","to","nuclear","factors","of","chicken","T-cells","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,1,2,0,0,0,0,9,10,0,7,8,0]}
{"id":"4178","tokens":["Finally",",","it","is","demonstrated","that","macrophages","in","the","adrenal","gland",",","the","major","site","of","endogenous","GC","production",",","express","sialoadhesin","."],"ner_tags":[0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"4943","tokens":["Cotransfection","of","a","CD44","promoter-chloramphenicol","acetyltransferase","reporter","construct","with","an","egr-1","expression","vector","resulted","in","a","6.5-","to","8.5-fold","induction","of","transcriptional","activity","relative","to","an","empty","expression","vector","."],"ner_tags":[0,0,0,1,2,2,2,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"2555","tokens":["Site","B","(","nt","4519","to","4545",")","specifically","bound","four","distinct","nuclear","protein","complexes",":","a","ubiquitous","factor",",","a","T-cell-specific","factor",",","a","B-cell-specific","factor",",","and","the","monocyte\/macrophage-","and","B-cell-specific","transcription","factor","PU.1\/Spi-1","."],"ner_tags":[1,2,0,1,2,2,2,0,0,0,0,0,9,10,10,0,0,9,10,0,0,9,10,0,0,9,10,0,0,0,9,10,10,10,10,9,0]}
{"id":"9783","tokens":["Phase-2","neutrophil","adhesion","was","attenuated","by","an","anti-E-selectin","mAb",",","indicating","a","dominant","role","of","this","adhesion","molecule","in","the","late","phase","response","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4718","tokens":["We","conclude","that","the","MAP","kinase","signal","transduction","pathway","consisting","of","Raf-1",",","MEK1",",","and","ERK1","and","ERK2","functions","in","the","stimulation","IL-2","gene","transcription","in","activated","T","lymphocytes","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,9,0,9,0,0,9,0,9,0,0,0,0,1,2,0,0,0,7,8,0]}
{"id":"8672","tokens":["JunB","-control","of","IL-4","expression","is","mediated","by","the","phosphorylation","of","JunB","at","Thr102","and-","104","by","JNK","MAP","kinase","."],"ner_tags":[9,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,10,0]}
{"id":"18184","tokens":["Phosphorylation","and","degradation","of","the","cytoplasmic","inhibitor","I","kappa","B","alpha","are","crucial","regulatory","events","in","the","activation","of","NF-kappa","B","DNA-binding","activity","."],"ner_tags":[0,0,0,0,0,9,10,9,10,10,0,0,0,0,0,0,0,0,0,9,10,0,0,0]}
{"id":"2500","tokens":["To","tie","these","events","to","gene","activation",",","we","measured","NF-kappa","B","and","NF-AT","activity","in","the","nucleus","after","anti-CD3","stimulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,9,0,0]}
{"id":"15855","tokens":["A","Tat-responsive","element","is","found","upstream","within","the","viral","promoter","that","in","glial-derived","cell","lines","allows","transactivation","in","the","absence","of","TAR","."],"ner_tags":[0,1,2,0,0,0,0,0,1,2,0,0,5,6,6,0,0,0,0,0,0,3,0]}
{"id":"3839","tokens":["The","positive","region","can","be","divided","into","an","upstream","and","a","downstream","regulatory","region","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,2,2,0]}
{"id":"722","tokens":["When","transfected","into","K562","cells",",","which","express","zeta-globin",",","comparable","amounts","of","activity","were","obtained","from","the","-557","and","-417","zeta-luciferase","constructs","and","the","alpha-luciferase","constructs","when","no","enhancers","or","the","alpha-globin","locus","enhancers","were","used","."],"ner_tags":[0,0,0,5,6,0,0,0,9,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,1,2,0,0,1,0,0,1,2,2,0,0,0]}
{"id":"4126","tokens":["Analysis","of","the","inactive","X","specific","methylation","at","the","androgen","receptor","gene","showed","unbalanced","inactivation","in","the","twins","'","fibroblasts","and","in","opposite","directions","."],"ner_tags":[0,0,0,1,2,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12245","tokens":["Taken","together",",","these","data","indicate","that","the","inducible","nuclear","import","of","NF-kappa","B",",","AP-1",",","NFAT",",","and","STAT1","in","Jurkat","T","cells","can","be","regulated","by","NLS","peptide","delivered","noninvasively","to","the","cytoplasm","of","Jurkat","T","cells","to","target","members","of","the","importin","(","karyopherin",")","-alpha","beta","NLS","receptor","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,0,0,9,0,5,6,6,0,0,0,0,9,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,9,10,10,10,10,10,9,10,10,0]}
{"id":"15960","tokens":["The","C-terminus","has","a","putative","protein","kinase","C","phosphorylation","site","."],"ner_tags":[0,9,0,0,0,9,10,10,10,10,0]}
{"id":"10990","tokens":["Inhibition","of","T","cell","activation","by","the","immunosuppressants","cyclosporin","A","(","CsA",")","and","FK506","exerts","a","suppressive","effect","on","the","induction","of","these","NF-kappa","B-controlled","cytokine","promoters","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"7786","tokens":["Expression","of","GrpL","is","restricted","to","hematopoietic","tissues",",","and","it","is","distinguished","from","Grb2","by","having","a","proline-rich","region","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,10,0]}
{"id":"7772","tokens":["Precise","regulation","of","MHC","class","II","expression","plays","a","crucial","role","in","the","control","of","the","immune","response","."],"ner_tags":[0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15999","tokens":["Regulation","of","M-CSF","expression","by","M-CSF",":","role","of","protein","kinase","C","and","transcription","factor","NF","kappa","B","."],"ner_tags":[0,0,9,0,0,9,0,0,0,9,10,10,0,9,10,10,10,10,0]}
{"id":"4818","tokens":["Octamer","binding","factors","and","their","coactivator","can","activate","the","murine","PU.1","(","spi-1",")","promoter","."],"ner_tags":[9,10,10,0,0,9,0,0,0,1,2,2,2,2,2,0]}
{"id":"18","tokens":["E1A","gene","expression","induces","susceptibility","to","killing","by","NK","cells","following","immortalization","but","not","adenovirus","infection","of","human","cells","."],"ner_tags":[1,2,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,7,8,0]}
{"id":"11028","tokens":["A","new","mouse","gene",",","SRG3",",","related","to","the","SWI3","of","Saccharomyces","cerevisiae",",","is","required","for","apoptosis","induced","by","glucocorticoids","in","a","thymoma","cell","line","."],"ner_tags":[0,0,1,2,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"10828","tokens":["The","range","of","G","(","S",")","alpha","expression","produced","was","found","to","mimic","a","physiologically","relevant","spectrum","of","G","(","S",")","alpha","expression","in","membranes","derived","from","human","tissues","and","rat","brain","."],"ner_tags":[0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10134","tokens":["These","findings","reveal","the","features","controlling","the","pp52","promoter","in","B","and","T","cells","and","provide","the","foundation","for","determining","the","regulation","of","this","promoter","in","other","leukocyte","lineages","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,1,0,0,7,8,0]}
{"id":"4208","tokens":["Aclacinomycin","(","ACLA",")","and","doxorubicin","(","DOX",")","were","used","at","subtoxic","concentrations","to","induce","erythroid","differentiation","in","the","human","leukemic","cell","line","K562","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,0]}
{"id":"16317","tokens":["The","disruption","of","HIV-TF1-binding","site","induced","a","60","%","decrease","in","the","level","of","transcription","from","the","HIV","promoter","in","vivo","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0]}
{"id":"1259","tokens":["Transcriptional","control","of","steroid-regulated","gene","networks","by","nuclear","receptor","proteins","results","in","the","coordinate","expression","of","a","limited","number","of","target","genes","."],"ner_tags":[0,0,0,1,2,2,0,9,10,10,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"321","tokens":["To","determine","if","New","World","primates","express","an","inhibitor","that","influences","glucocorticoid","receptor","(","GR",")","binding","characteristics",",","we","examined","[","3H","]","dexamethasone","binding","in","cytosol","prepared","from","B95-8","lymphoid","cells",",","derived","from","the","cotton","top","tamarin","(","Saguinus","oedipus",")",",","in","combination","with","cytosol","prepared","from","human","or","rat","tissues","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13828","tokens":["The","efficacy","of","the","activated","LN","cells","is","augmented","when","the","sensitizing","tumor","is","a","genetically","modified","variant","(","designated","D5G6",")","that","secretes","granulocyte\/macrophage-colony-stimulating","factor","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,5,6,6,0,0,5,0,0,0,9,10,0]}
{"id":"13661","tokens":["The","products","of","the","tumor","suppressor","genes","are","considered","to","function","as","specific","inhibitors","of","tumor","cell","growth","."],"ner_tags":[0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15935","tokens":["Other","factors","are","induced","by","lectin",",","antibody",",","and\/or","PMA","alone","."],"ner_tags":[0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"382","tokens":["We","now","demonstrate","that","B7",",","but","not","LFA-3",",","strongly","costimulated","IL-2","transcription","and","mRNA","expression","in","CD4+","T","cells","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,0,0,9,0,0,0,0,0,5,6,6,0]}
{"id":"11966","tokens":["Furthermore",",","no","induction","of","AP-1","was","seen","in","A6H","costimulated","CD8+","T","cells","."],"ner_tags":[0,0,0,0,0,9,0,0,0,9,0,7,8,8,0]}
{"id":"7455","tokens":["Binding","of","interferon-gamma","(","IFN-gamma",")","to","its","heterodimeric","receptor","induces","activation","of","the","tyrosine","kinases","JAK1","and","JAK2","followed","by","tyrosine","phosphorylation","of","STAT1alpha","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,0,0,0,0,9,10,9,0,9,0,0,0,0,0,9,0]}
{"id":"4727","tokens":["Mutations","at","different","sites","within","this","proximal","promoter","region","abolished","the","promoter","activity","as","well","as","the","DNA","binding","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7821","tokens":["Here",",","we","report","the","functional","expression","of","CD40","on","human","malignant","melanomas","(","MMs",")","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"13012","tokens":["Northern","analysis","confirmed","that","expression","of","both","mRNAs","was","reduced","in","cells","with","decreased","numbers","of","VDR","."],"ner_tags":[0,0,0,0,0,0,0,3,0,0,0,0,0,0,0,0,9,0]}
{"id":"2025","tokens":["ZAP-70","tyrosine","kinase",",","CD45",",","and","T","cell","receptor","involvement","in","UV-","and","H2O2-induced","T","cell","signal","transduction","."],"ner_tags":[9,10,10,0,9,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"10207","tokens":["Epitope","enhancement","was","used","to","confirm","the","strict","lineage-","and","stage-specific","expression","of","MNDA","in","bone","marrow","as","well","as","in","other","paraffin-embedded","fixed","tissues","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16196","tokens":["Inhibition","of","phorbol","ester-induced","monocytic","differentiation","by","dexamethasone","is","associated","with","down-regulation","of","c-fos","and","c-jun","(","AP-1",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,1,0,0]}
{"id":"14734","tokens":["Ionizing","radiation","triggers","a","signal","in","human","B-lymphocyte","precursors","that","is","intimately","linked","to","an","active","protein-tyrosine","kinase","regulatory","pathway","."],"ner_tags":[0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,9,10,0,0,0]}
{"id":"4738","tokens":["Finally",",","GM3","greatly","reduced","the","concentration","of","endogenous","GM-CSF","mRNA","induced","by","different","stimuli","in","Jurkat","T","cells","but","did","not","affect","interleukin","3","mRNA","levels","in","the","same","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,5,6,6,0,0,0,0,3,4,4,0,0,0,0,0,0]}
{"id":"2218","tokens":["The","Tat","-mediated","increase","in","IL-2","promoter","activity","could","selectively","be","blocked","by","antisense","tat","or-unlike","the","analogous","effect","of","human","T-cell","lymphotropic","virus","type","1","Tax","-by","cyclosporin","A","."],"ner_tags":[0,9,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,10,0,0,0,0]}
{"id":"13200","tokens":["Identification","of","transcription","factors","expressed","during","ATRA-induced","neutrophil","differentiation","of","HL60","cells","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,5,6,0]}
{"id":"9186","tokens":["We","conclude","that","FMS","patients","have","a","mild","hypocortisolemia",",","increased","cortisol","feedback","resistance","in","combination","probably","with","a","reduced","CRH","synthesis","or","release","in","the","hypothalamus","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17669","tokens":["In","contrast",",","MZF-1","activates","CAT","reporter","gene","expression","in","the","hematopoietic","cell","lines","K562","and","Jurkat","."],"ner_tags":[0,0,0,1,0,1,2,2,0,0,0,5,6,6,5,0,5,0]}
{"id":"12904","tokens":["Progesterone","effectively","blocked","a","broad","spectrum","of","K+","channels",",","reducing","both","Kv1.3","and","charybdotoxin-resistant","components","of","KV","current","and","KCa","current","in","T","cells",",","as","well","as","blocking","several","cloned","KV","channels","expressed","in","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,9,0,9,10,0,9,0,0,9,0,0,7,8,0,0,0,0,0,0,9,10,10,0,0,5,6,0]}
{"id":"5784","tokens":["We","have","previously","shown","that","gene","expression","directed","by","the","HIV-1","NF","kappa","B","elements","is","inhibited","by","CD8","+","cell-derived","supernatants","(","Copeland","et","al.",",","AIDS","Res","Hum","Retroviruses",",","1995",";","11",":","1321-1326",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1929","tokens":["Although","ICAM-1","induction","was","unaffected",",","inhibitors","of","NADPH","oxidase","(","apocynin",")","or","cytochrome","P-450","(","SKF525a",")","suppressed","VCAM-1","induction","by","TNF",",","revealing","that","several","radical-generating","systems","are","involved","in","its","regulation","."],"ner_tags":[0,9,0,0,0,0,0,0,9,10,0,0,0,0,9,10,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6591","tokens":["Strikingly",",","despite","the","observed","repertoire","heterogeneity",",","all","clones","displayed","a","narrow","range","of","MHC","\/peptide","density","requirements","in","cytotoxicity","assays","(","ED50","between","9","and","36","nM",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14322","tokens":["The","human","erythroleukemia","cell","line","K562","can","be","induced","to","differentiate","along","the","erythroid","and","megakaryocytic","lineages","."],"ner_tags":[0,5,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13178","tokens":["These","results","suggest","that","the","adherence\/contact","of","SS","RBC","to","endothelial","cells","in","large","vessel","can","generate","enhanced","oxidant","stress","leading","to","increased","adhesion","and","diapedesis","of","monocytes",",","as","well","as","heightened","adherence","of","SS","reticulocytes",",","indicating","that","injury\/activation","of","endothelium","can","contribute","to","vaso-occlusion","in","SCD","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9019","tokens":["IL-10","preincubation","resulted","in","the","inhibition","of","gene","expression","for","several","IFN-induced","genes",",","such","as","IP-10",",","ISG54",",","and","intercellular","adhesion","molecule-1","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,9,0,9,0,0,9,10,10,0]}
{"id":"18419","tokens":["It","is","tempting","to","speculate","that","enhanced","NF-kappa","B","expression","caused","by","free","radical","production\/oxidative","stress","may","modulate","liver","injury",",","perhaps","through","an","effect","on","cytotoxic","cytokine","synthesis","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"14543","tokens":["Competition","with","an","AP-1","motif","or","with","anti-Jun","and","anti-Fos","antibodies","abolished","binding","to","the","NFAT","motif","in","both","T","and","B","cells",",","indicating","that","Jun","and","Fos","are","critical","for","NFAT","complex","formation","in","both","cell","types","."],"ner_tags":[0,0,0,1,2,0,0,9,0,9,10,0,0,0,0,1,2,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"823","tokens":["It","was","identified","as","NF-E1","(","YY1",")","."],"ner_tags":[0,0,0,0,9,0,9,0,0]}
{"id":"2862","tokens":["Treatment","with","calcium","ionophore","A23187","increased","Zp","activity","."],"ner_tags":[0,0,0,0,0,0,1,0,0]}
{"id":"2309","tokens":["LIF","induced","a","dose-dependent","increase","in","p24","antigen","production","in","the","chronically","infected","promonocytic","cell","line","U1","."],"ner_tags":[9,0,0,0,0,0,9,10,0,0,0,5,6,6,6,6,6,0]}
{"id":"2439","tokens":["The","system","described","here","may","serve","as","a","model","for","studying","the","the","essential","genes","for","differentiation","of","normal","bone","marrow","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,7,8,8,8,0]}
{"id":"6663","tokens":["Co-transfection","experiments","confirm","that","Aiolos","induces","Bcl-2","expression","and","prevents","apoptosis","in","IL-2-deprived","cells","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,5,6,0]}
{"id":"9112","tokens":["Three","days","after","establishing","high-density","PBMC","cultures","(","1.5","x","10","(","6",")","cells\/cm2",")",",","in","serum-containing","medium",",","small","adherent","colonies","of","tartrate","resistant","acid","phosphatase","positive","(","TRAP+",")","cells","emerge",",","amidst","massive","monocyte","cell","death","."],"ner_tags":[0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,5,6,6,6,6,6,6,6,6,0,0,0,0,0,0,0,0]}
{"id":"7117","tokens":["RESULTS",":","In","peripheral","blood","of","healthy","pregnant","women","the","percentage","of","gamma\/delta","TCR+","cells","was","significantly","higher","(","P","<","0.001",")","than","in","that","of","recurrent","aborters","or","of","non-pregnant","individuals","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15377","tokens":["The","transcriptional","activity","of","the","heterodimer","is","regulated","by","signal-dependent","phosphorylation","and","dephosphorylation","events","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11517","tokens":["During","the","treatment","with","As2O3",",","there","was","no","bone","marrow","depression","and","only","limited","side","effects","were","encountered","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8826","tokens":["Specific","staining","as","well","as","electron","microscopic","examinations","revealed","the","accumulation","of","metal","gold","in","the","cells",",","supporting","our","previous","hypothesis","that","gold","ions","could","block","NF-kappaB","-DNA","binding","by","a","redox","mechanism","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"10233","tokens":["Bufalin","treatment","activated","activator","protein-1","transcriptional","activity",";","however",",","this","activation","was","decreased","to","40","%","in","bcl-2","-overexpressed","U937","cells","."],"ner_tags":[0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,5,6,0]}
{"id":"1782","tokens":["ERP",",","a","new","member","of","the","ets","transcription","factor\/oncoprotein","family",":","cloning",",","characterization",",","and","differential","expression","during","B-lymphocyte","development","."],"ner_tags":[9,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10186","tokens":["The","MHC","class","II","homologous","proteins","HLA-DMA","and","HLA-DMB","function","in","the","loading","of","peptides","onto","class","II","molecules","."],"ner_tags":[0,9,10,10,10,10,9,0,9,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"386","tokens":["The","CHO-DR\/B7\/LFA-3","triple","transfectant","induced","a","further","increase","in","AP-1","and","NF-kappa","B","binding","proteins","compared","with","the","double","transfectants","."],"ner_tags":[0,5,6,6,0,0,0,0,0,9,0,9,10,9,10,0,0,0,5,6,0]}
{"id":"10910","tokens":["The","common","gamma-chain","(","gamma","(","c",")",")","is","a","functional","component","of","the","IL-4R",",","yet","cells","lacking","gamma","(","c",")","are","able","to","respond","to","IL-4","."],"ner_tags":[0,9,10,0,9,10,10,10,0,0,0,0,0,0,0,9,0,0,0,0,9,10,10,10,0,0,0,0,0,9,0]}
{"id":"8286","tokens":["This","modulation","of","DNA","binding","activity","mediated","through","the","dephosphorylation","of","DP1","and","E2F4","could","help","to","explain","the","lack","of","in","vivo","DNA","footprinting","in","late","G1","and","S","phases","of","gene","promoters","negatively","regulated","through","E2F","sites","and","suggests","a","novel","mechanism","for","controlling","E2F","transcriptional","activity","during","the","transition","from","quiescence","to","proliferation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"11827","tokens":["In","Jurkat","cells",",","a","human","T-cell","lymphoma","cell","line",",","tumor","necrosis","factor-alpha","(","TNF-alpha",")","induces","NF","kappaB","activation","that","is","inhibited","by","PDTC","."],"ner_tags":[0,5,6,0,0,0,5,6,6,6,0,9,10,10,0,9,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"3413","tokens":["More","interestingly",",","transfection","experiments","with","CRE-CAT","plasmide","show","that","PGE2","activates","the","transcription","of","a","CRE-containing","promoter","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"106","tokens":["A","functional","T-cell","receptor","signaling","pathway","is","required","for","p95vav","activity","."],"ner_tags":[0,0,9,10,0,0,0,0,0,9,0,0]}
{"id":"15519","tokens":["2","."],"ner_tags":[0,0]}
{"id":"12543","tokens":["As","determined","by","transient","expression","and","RNA","analyses",",","the","activation","of","protein","kinase","C","(","PKC",")","also","increased","rates","of","transcription","from","the","wild-type","DRA","promoter","but","not","from","a","DRA","promoter","bearing","clustered","point","mutations","in","the","X2","box","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,1,2,0,0,0,0,0,0,1,2,0]}
{"id":"1278","tokens":["A","second","transcript","was","identified","as","encoding","the","recently","characterized","RAZ",",","which","also","is","associated","with","replicative","infection","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"12076","tokens":["Strength","of","T","cell","receptor","(","TCR",")","signaling",",","coreceptors",",","costimulation",",","antigen-presenting","cell","type",",","and","cytokines","all","play","crucial","roles","in","determining","the","efficiency","with","which","type","2","T","lymphocytes","(","Th2",",","Tc2",")","develop","from","uncommitted","precursors","."],"ner_tags":[0,0,9,10,10,0,9,0,0,0,9,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,7,0,7,0,0,0,9,10,0]}
{"id":"15193","tokens":["Estrogen","receptor","positive","(","ER+",":","MCF-7",")","and","negative","(","ER-",":","MDA-MB-231",")","human","breast","cancer","cell","lines","were","utilized","to","evaluate","the","effects","of","tamoxifen","(","TAM",")","and","estradiol","(","E2",")","on","modulation","of","breast","cancer","target","susceptibility","to","lysis","by","lymphokine-activated","killer","(","LAK",")","cells","."],"ner_tags":[5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,8,0]}
{"id":"4623","tokens":["To","determine","whether","the","IL-10R","has","signaling","functions","similar","to","IL-6R","in","cells","normally","expressing","these","receptors",",","leukocytes","of","the","B-",",","T-",",","and","NK-cell","lineages","were","treated","with","either","cytokine","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,7,0,0,7,8,8,8,8,8,8,0,0,0,0,0,0]}
{"id":"14000","tokens":["Erythroid","Kruppel-like","factor","(","EKLF",")","is","a","red","cell-specific","transcriptional","activator","that","is","crucial","for","consolidating","the","switch","to","high","levels","of","adult","beta-globin","expression","during","erythroid","ontogeny","."],"ner_tags":[9,10,10,0,9,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"18063","tokens":["Although","anti-CD28","MoAb","costimulation","enhances","all","of","the","above","signals",",","NF","kappa","B","and","IL-2","levels","remain","lower","than","in","adults",",","suggesting","the","need","for","further","activation","requirements","in","the","neonate","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3200","tokens":["Interleukin","2","(","IL-2",")","stimulates","IL-2R","alpha","."],"ner_tags":[9,10,0,9,0,0,9,10,0]}
{"id":"11482","tokens":["When","BALB\/c","mice","were","inoculated","with","E1","-deleted","Ad","vectors",",","only","the","immunodominant","Kd-restricted","epitope","was","recognized",",","and","Dd-restricted","CTLs","did","not","develop","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,0,0,0,9,10,10,0,0,0,0,0,7,0,0,0,0]}
{"id":"5090","tokens":["Erythroid","colony","growth","was","also","inhibited","when","CD34+","progenitors","were","seeded","at","one","cell","per","well",",","suggesting","a","direct","action","of","RA","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12779","tokens":["We","demonstrate","here","that","the","SLP-76","linker","protein","interacts","with","both","nck",",","an","adaptor","protein",",","and","Vav",",","a","guanine","nucleotide","exchange","factor","for","Rho-family","GTPases","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,9,0,0,9,10,0,0,9,0,0,9,10,10,10,0,9,10,0]}
{"id":"17594","tokens":["Besides","in","T-lymphocytes","NFAT-1","activity","could","also","be","induced","in","T-lymphocyte-depleted","spleen","cells","and","purified","B-lymphocytes","and","requires","agents","that","both","release","intracellular","calcium","and","activate","protein","kinase","C","."],"ner_tags":[0,0,7,9,0,0,0,0,0,0,7,8,8,0,7,8,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"15965","tokens":["In","both","wild-type","and","highly","dexamethasone","(","dex",")","-resistant","clones","of","the","human","leukemic","cell","line","CEM",",","exposure","to","cortivazol","leads","to","cell","death","."],"ner_tags":[0,0,5,0,0,5,6,6,6,6,6,0,0,5,6,6,6,6,0,0,0,0,0,0,0,0,0]}
{"id":"8050","tokens":["These","lipid","mediators","increase","activity","of","transcription","factors","and","expression","of","cytokine","genes","indicating","a","function","for","cytosolic","phospholipase","A2","in","signal","transduction","and","inflammation","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,1,2,0,0,0,0,9,10,10,0,0,0,0,0,0]}
{"id":"5258","tokens":["These","data",",","along","with","previous","reports","of","rare","variant","translocations","in","APL",",","indicate","that","while","dysregulation","of","RARA","by","gene","fusion","may","be","essential","for","the","APL","phenotype",",","the","particular","fusion","partner","may","determine","clinicopathological","aspects",",","including","presentation",",","response","to","treatment","with","all-trans","retinoic","acid","(","ATRA",")",",","and","prognosis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8233","tokens":["In","this","study","we","examined","the","influence","of","local","estrogen","metabolism","on","the","differentiation","of","HL60","cells","and","normal","primitive","myeloid","progenitor","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,7,8,8,0]}
{"id":"16860","tokens":["A","pharmacodynamic","model","for","basophil","cell","distribution","to","and","from","an","extravascular","compartment","describes","the","effects","of","MP","after","both","regimens","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9887","tokens":["Both","IL-2","and","IL-7","induced","substantial","amounts","of","STAT5A","\/STAT5B","heterodimerization","."],"ner_tags":[0,9,0,9,0,0,0,0,9,9,0,0]}
{"id":"4140","tokens":["In","allergic","bronchial","asthma",",","inflammation","seems","to","be","orchestrated","predominantly","by","a","subset","of","T","lymphocytes",",","with","a","phenotype","similar","to","the","Th2","subset","able","to","produce","IL-4","and","IL-5","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,7,8,0,0,0,9,0,9,0]}
{"id":"545","tokens":["Circular","dichroism","analysis","reveals","that","NO","induces","a","profound","conformational","change","in","p21ras","in","association","with","GDP\/GTP","exchange","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0]}
{"id":"18198","tokens":["The","DNA","binding","region","specifying","high","affinity","for","GRE","sites","is","required","."],"ner_tags":[0,9,10,10,0,0,0,0,1,2,0,0,0]}
{"id":"15005","tokens":["TPA","induction","increases","the","binding","of","ubiquitous","AP-1","factors","to","this","element","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0,0]}
{"id":"1308","tokens":["GM-kappa","B","defines","a","binding","site","for","NF-kappa","B",",","and","GC-box","defines","a","binding","site","for","three","(","A1",",","A2",",","B",")","constitutive","proteins","."],"ner_tags":[9,10,0,0,0,0,0,9,10,0,0,1,0,0,0,0,0,0,0,9,0,9,0,9,0,9,10,0]}
{"id":"16845","tokens":["Lipopolysaccharide","is","a","potent","monocyte\/macrophage-specific","stimulator","of","human","immunodeficiency","virus","type","1","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13545","tokens":["Compared","to","the","parental","cell","line","the","dose-response","curve","of","IL-1","-induced","IL-2","production","was","shifted","in","both","potency","and","efficacy","."],"ner_tags":[0,0,0,5,6,6,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"4029","tokens":["Understanding","how","viral","latency","is","disrupted","is","a","central","issue","in","herpesvirus","biology","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12272","tokens":["Blood","monocytes","spontaneously","activate","endothelial","cells","in","culture",",","leading","to","adhesion","of","monocytic","cells","onto","the","endothelial","surface","and","overproduction","of","endothelial","proteins","such","as","von","Willebrand","factor","(","vWf",")","and","plasminogen","activator","inhibitor","type","1","(","PAI-1",")","."],"ner_tags":[7,8,0,0,7,8,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,9,10,10,10,10,0,9,0,0]}
{"id":"12463","tokens":["The","amount","of","vimentin","mRNA","was","also","increased","during","recovery","from","stress",",","indicating","that","vimentin","expression","was","not","exclusively","regulated","at","the","protein","level","."],"ner_tags":[0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"14640","tokens":["G0S24","has","potential","sites","for","transcription","factors","in","the","5","'","flank","and","intron",";","these","include","a","serum","response","element","."],"ner_tags":[1,0,0,0,0,9,10,0,0,1,2,2,0,1,0,0,0,0,1,2,2,0]}
{"id":"13526","tokens":["Each","site","is","functionally","important","and","contributes","independently","to","transcription","of","the","NF-IL6","gene","in","U937","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,5,6,0]}
{"id":"2554","tokens":["Using","in","vitro","footprinting","and","gel","shift","assays",",","we","have","identified","four","distinct","binding","sites","for","nuclear","proteins","within","this","positive","regulatory","element","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,9,10,0,0,1,2,2,0]}
{"id":"6501","tokens":["This","remodeling","of","promoter","chromatin","structure","resulted","in","3-fold","increases","in","beta-globin","gene","transcription","and","induction",",","and","inhibited","long-term","beta-globin","gene","silencing","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"10152","tokens":["While","dexamethasone","(","0.1","nmol\/L","to","100","mumol\/L",")","did","not","affect","expression","of","adhesion","molecules","on","resting","neutrophils",",","it","attenuated","the","PAF","-induced","changes","in","L-selectin","and","CD18","expression","in","a","time-","and","concentration-dependent","fashion","with","IC50","values","of","31","and","13","nmol\/L",",","respectively","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,8,0,0,0,0,9,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10582","tokens":["One","of","them",",","hT86",",","encoding","a","putative","zinc","finger","protein","was","found","to","derepress","beta-galactosidase","activity","in","the","Oct-2","-harboring","tester","strain","at","the","transcriptional","level","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"14602","tokens":["This","resurgence","of","I","kappa","B-alpha","protein","acts","to","restore","an","equilibrium","in","which","NF-kappa","B","is","again","inhibited","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"7023","tokens":["Furthermore",",","PML","and","pRb","105","were","co-immunoprecipitated","in","cellular","lysates","derived","from","erythroid","precursors","indicating","that","this","functional","interaction","may","have","a","biochemical","basis","."],"ner_tags":[0,0,9,0,9,10,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7428","tokens":["The","expression","of","human","PCD\/DCoH","in","the","liver","and","nonhepatic","cells","was","compared","at","both","the","mRNA","and","protein","levels","."],"ner_tags":[0,0,0,9,10,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"3342","tokens":["rel","Is","rapidly","tyrosine-phosphorylated","following","granulocyte-colony","stimulating","factor","treatment","of","human","neutrophils","."],"ner_tags":[9,0,0,0,0,9,10,10,0,0,0,0,0]}
{"id":"7277","tokens":["To","determine","activation","status","of","the","IL-2R","-associated","(","Jak\/STAT",")","pathway","in","the","HTLV-I","infected","cells",",","we","examined","tyrosine","phosphorylation","of","Jak3",",","STAT3",",","and","STAT5","in","several","HTLV-I","(","+",")","T-cell","lines","and","in","uncultured","leukemic","T","cells","isolated","from","patients","with","adult","T-cell","lymphoma\/leukemia","(","ATLL",")","."],"ner_tags":[0,0,0,0,0,0,9,0,0,9,0,0,0,0,5,6,6,0,0,0,0,0,0,9,0,9,0,0,9,0,0,5,6,6,6,6,6,0,0,7,8,8,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16108","tokens":["TCF-1","consists","of","two","polypeptides","of","about","50","kD","and","105","kD",";","the","former","seems","to","be","related","to","the","50","kD","polypeptide","of","NF-kB","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0]}
{"id":"5687","tokens":["Due","to","its","location","within","this","cluster","and","its","biologic","role","in","Ig","class","switching","and","Th2","cell","differentiation",",","the","IL-4","gene","has","emerged","as","one","major","candidate","for","the","atopy","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"16286","tokens":["Thus",",","the","``","estrogen","receptor-related","protein","''","is","HSP27",",","and","the","three","major","29-kDa","proteins","phosphorylated","in","thrombin-activated","platelets","are","forms","of","HSP27","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,0,0,7,8,0,0,0,9,0]}
{"id":"18266","tokens":["Immunofluorescence","colocalization","of","both","estrogen","and","progesterone","receptors","with","eosinophil","cationic","protein","showed","that","approximately","70","%","of","positive","cells","were","eosinophils","."],"ner_tags":[0,0,0,0,9,0,9,10,0,9,10,10,0,0,0,0,0,0,7,8,0,7,0]}
{"id":"5898","tokens":["The","full","differentiation","response","with","combinations","of","analogs","and","TPA","was","inhibited","50","%","by","the","membrane","permeable","Ca2+","chelator",",","1",",","2-bis","(","o-aminophenoxy",")","-ethane-N",",","N",",","N","'",",","N'-tetraacetic","acid","(","BAPTA-AM",")","or","calpain","inhibitor","I","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"16520","tokens":["In","contrast",",","mutation","of","the","kappa","B","enhancer","results","in","markedly","attenuated","activities","of","both","promoters","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,1,0]}
{"id":"9812","tokens":["The","distribution","of","myeloid","lineage-associated","cytokine","receptors","and","lysosomal","proteins","was","analyzed","in","human","CD34+","cord","blood","cell","(","CB",")","subsets","at","different","stages","of","myeloid","commitment","by","reverse-transcriptase","polymerase","chain","reaction","(","RT-PCR",")","."],"ner_tags":[0,0,0,9,10,10,10,0,9,10,0,0,0,5,6,6,6,6,6,6,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7003","tokens":["It","also","appears","that","NF-kappaB","suppression","by","RCC-S","may","contribute","to","the","immunosuppression","of","host","immunity","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13343","tokens":["The","mutation","may","have","implications","for","some","physiological","roles","of","DARC","and","be","of","interest","in","malaria","research","and","in","studies","of","population","genetics","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6553","tokens":["In","the","present","study",",","we","have","identified","a","cellular","context","(","the","interleukin-2","[","IL-2","]","-dependent","HT-2","line",")","in","which","the","EPO","stimulation","of","the","EPOR","fails","to","support","cellular","proliferation",",","STAT-5","induction",",","or","MAPK","activation",",","despite","efficient","phosphorylation","of","the","EPOR","and","JAK2","and","inhibition","of","apoptosis","after","withdrawal","of","IL-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"7435","tokens":["The","maintenance","of","lymphocyte","homeostasis","by","apoptosis","is","a","critical","regulatory","mechanism","in","the","normal","immune","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8310","tokens":["To","further","identify","intracellular","signals","and","downstream","events","important","in","CD34+","HPC","--",">","DC","differentiation","we","have","characterized","a","human","leukemic","cell","line","model","of","this","process","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3750","tokens":["Importantly",",","culture","of","MM","cells","with","RB","antisense",",","but","not","RB","sense",",","oligonucleotide","(","ODN",")","triggered","IL-6","secretion","and","proliferation","in","MM","cells",";","however",",","proliferation","was","only","partially","inhibited","by","neutralizing","anti-IL-6","monoclonal","antibody","(","MoAb",")","."],"ner_tags":[0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"17292","tokens":["This","is","in","contrast","to","the","result","that","as","many","as","20","copies","of","the","cyclophilin","gene","and","possible","pseudogenes","may","be","present","in","the","mammalian","genome","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"12581","tokens":["Isolation","and","utilization","of","human","dendritic","cells","from","peripheral","blood","to","assay","an","in","vitro","primary","immune","response","to","varicella-zoster","virus","peptides","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1895","tokens":["In","a","mobility","shift","assay",",","only","the","NF-kappa","B","(","p50\/p50",")","homodimer","was","observed","in","a","complex","formed","with","the","kappa","B","sequence","in","unstimulated","SP-B21","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0]}
{"id":"6340","tokens":["In","selenium-deprived","Jurkat","and","ESb-L","T","lymphocytes",",","supplementation","of","selenium","led","to","a","substantial","increase","of","GPX","activity","."],"ner_tags":[0,5,6,0,5,6,6,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"14680","tokens":["PBL","constitutively","express","c-jun","transcripts",",","and","the","level","of","c-jun","mRNA","is","not","altered","by","PHA","activation","in","the","absence","or","presence","of","EC","."],"ner_tags":[7,0,0,9,10,0,0,0,0,0,3,4,0,0,0,0,9,0,0,0,0,0,0,0,7,0]}
{"id":"13939","tokens":["RARs","and","RXRs","form","heterodimers","and","regulate","retinoid-mediated","gene","expression","."],"ner_tags":[9,0,9,0,9,0,0,0,0,0,0]}
{"id":"6287","tokens":["AML1","plays","a","critical","role","during","hematopoiesis","and","chromosomal","translocations","involving","AML1","are","commonly","associated","with","different","forms","of","leukemia",",","including","pre-B","acute","lymphoblastic","leukemia","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16906","tokens":["Moreover",",","hesperidin",",","a","flavonoid","which","does","not","bind","to","type-II","EBS",",","was","ineffective","in","inhibiting","cell","growth","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"4340","tokens":["Similarly",",","the","complexes","binding","the","consensus","AP-1","TRE","and","jun","TRE-like","motifs","in","cells","exposed","to","oxidative","signals","or","PHA\/PMA","were","indistinguishable",",","being","composed","of","c-Fos",",","c-Jun",",","and","JunD","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,0]}
{"id":"14565","tokens":["In","contrast",",","there","was","no","regulation","by","glucocorticoids","of","either","the","CD8","or","CD4","antigens","in","the","leukemic","clone","CEM","C1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0,0,5,6,6,6,0]}
{"id":"1930","tokens":["PDTC",",","apocynin",",","or","SKF525a","decreased","adhesion","of","monocytic","U937","cells","to","TNF-treated","HUVECs","(","by","75","%","at","100","mumol\/L","PDTC",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,6,0,5,6,0,0,0,0,0,0,0,0,0,0]}
{"id":"6760","tokens":["Such","compounds","have","been","shown","to","favor","IgE","production",",","bronchial","hyperresponsiveness",",","and","airway","inflammation","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"7592","tokens":["The","interactions","of","Hsp60-specific","T","cells","with","arterial","endothelial","cells","(","EC",")","require","expression","of","both","Hsp60","and","certain","adhesion","molecules","shown","to","be","induced","simultaneously","in","EC","by","mechanical","and","other","types","of","stress","."],"ner_tags":[0,0,0,5,6,6,0,0,7,8,0,7,0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0]}
{"id":"12683","tokens":["This","antibody","also","recognizes","in","human","T","lymphocytes","a","70-kDa","protein","corresponding","in","size","to","that","predicted","for","the","fkhrl1","gene","product","."],"ner_tags":[0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"4920","tokens":["The","expression","of","MIP-1","alpha","is","induced","during","cellular","activation","of","CD4+","T-cells","and","monocytes","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,7,8,0,7,0]}
{"id":"16365","tokens":["Ectopic","expression","of","cloned","Oct2","cDNA","was","shown","to","be","sufficient","to","reconstitute","at","least","some","aspects","of","this","regulation","in","non-lymphoid","cells","."],"ner_tags":[0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"16758","tokens":["Deletions","upstream","of","the","PRDII","element","increased","transcription","in","the","uninduced","extract",",","indicating","predominantly","negative","regulation","of","the","promoter","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0]}
{"id":"10773","tokens":["The","mitogenic","combination","of","anti","CD2","+","anti","CD28","released","the","footprint","as","cells","were","committed","to","proliferation","."],"ner_tags":[0,0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"8097","tokens":["Because","these","induced","gene","products","have","NF-kappaB","sites","in","their","promoter","regions",",","we","next","examined","whether","there","was","an","up-regulation","of","nuclear","NF-kappaB","levels","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"13606","tokens":["Significantly",",","expression","of","the","newly","identified","Fas-regulatory","gene",",","TDAG51",",","was","found","to","be","dependent","upon","the","activity","of","PKC","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,1,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"2216","tokens":["Analysis","of","mRNA","suggested","that","Tat","exerts","its","effect","on","IL-2","primarily","at","the","transcriptional","level","."],"ner_tags":[0,0,3,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"15959","tokens":["One","of","the","induced","transcripts","(","MAD-3",")","encodes","a","protein","of","317","amino","acids","with","one","domain","containing","five","tandem","repeats","of","the","cdc10\/ankyrin","motif",",","which","is","60","%","similar","(","46","%","identical",")","to","the","ankyrin","repeat","region","of","the","precursor","of","NF-kappa","B\/KBF1","p50","."],"ner_tags":[0,0,0,0,0,0,3,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,9,10,10,0]}
{"id":"14425","tokens":["The","eukaryotic","transcription","factor","nuclear","factor-kappa","B","(","NF-kappa","B",")","participates","in","many","parts","of","the","genetic","program","mediating","T","lymphocyte","activation","and","growth","."],"ner_tags":[0,0,9,10,9,10,10,0,9,10,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0]}
{"id":"15460","tokens":["Activation","of","T","cells","is","initiated","by","the","recognition","of","antigen","on","antigen","presenting","cells","to","exert","the","effector","functions","in","immune","and","inflammatory","responses","."],"ner_tags":[0,0,7,8,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4286","tokens":["Importantly",",","two","previously","characterized","mutants","with","point","mutations","in","Tax",",","M32","(","Y196A",",","K197S",")","and","M41","(","H287A",",","P288S",")",",","which","were","shown","to","be","defective","in","Tax","-activated","transcription","were","unable","to","interact","with","TFIIA","in","this","assay","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,9,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"16447","tokens":["With","the","antibodies","Ki-67","and","anti-p-145","an","increased","rate","of","nuclear","and","nucleolar","staining","resulted","in","cells","from","highly","malignant","lymphomas","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9274","tokens":["This","study","tested","the","hypothesis","that","anti-LPS","Abs","neutralize","endotoxin","by","blocking","cellular","uptake","through","mCD14","."],"ner_tags":[0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,9,0]}
{"id":"17557","tokens":["Differences","in","transcriptional","enhancers","of","HIV-1","and","HIV-2","."],"ner_tags":[0,0,1,2,0,0,0,0,0]}
{"id":"109","tokens":["It","contains","a","number","of","structural","motifs",",","including","Src","homology","2",",","Src","homology","3",",","and","pleckstrin","homology","domains","and","a","putative","guanine","nucleotide","exchange","domain","."],"ner_tags":[0,0,0,0,0,9,10,0,0,9,10,10,10,10,10,10,10,10,10,10,10,0,0,9,10,10,10,10,0]}
{"id":"3673","tokens":["Protein-tyrosine","kinase","activation","is","required","for","lipopolysaccharide","induction","of","interleukin","1beta","and","NFkappaB","activation",",","but","not","NFkappaB","nuclear","translocation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,9,0,0,0]}
{"id":"3167","tokens":["BACKGROUND","."],"ner_tags":[0,0]}
{"id":"14462","tokens":["The","p65","subunit","of","NF-kappa","B","regulates","I","kappa","B","by","two","distinct","mechanisms","."],"ner_tags":[0,9,10,0,9,10,0,9,10,10,0,0,0,0,0]}
{"id":"7520","tokens":["In","addition",",","bronchoalveolar","lavage","levels","of","tumor","necrosis","factor-alpha","(","TNF-alpha",")","and","the","CXC","chemokine",",","macrophage","inflammatory","protein-2",",","were","substantially","reduced","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,9,10,0,9,10,10,0,0,0,0,0]}
{"id":"17752","tokens":["Transcription","factors","belonging","to","the","NF-kappa","B","family","are","controlled","by","inhibitory","I","kappa","B","proteins",",","mainly","I","kappa","B","alpha","and","I","kappa","B","beta","."],"ner_tags":[9,10,0,0,0,9,10,10,0,0,0,9,10,10,10,10,0,0,9,10,10,10,0,9,10,10,10,0]}
{"id":"2324","tokens":["Two","anti-MHC","class","II","Ab",",","L227","and","2.06",",","inhibited","the","growth","of","B104","cells",",","although","2.06",",","but","not","L227",",","needed","to","be","further","cross-linked","with","a","goat","anti-mouse","IgG","Ab","(","GAM",")","to","show","the","effect","."],"ner_tags":[0,9,10,10,10,0,9,0,9,0,0,0,0,0,5,6,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,9,10,10,10,0,9,0,0,0,0,0,0]}
{"id":"724","tokens":["When","sequences","from","-417","to","-207","5","'","to","the","zeta-globin","mRNA","cap","site","were","deleted",",","up","to","95","%","of","the","zeta-globin","promoter","activity","was","lost","in","K562","cells","."],"ner_tags":[0,1,2,2,2,2,2,2,0,0,3,4,4,4,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,5,6,0]}
{"id":"14328","tokens":["In","contrast","to","MEL","cells",",","however",",","K562","cells","acquired","a","macrophage-like","morphology","and","exhibited","a","complete","failure","to","generate","benzidine-positive","cells","."],"ner_tags":[0,0,0,5,6,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"11851","tokens":["In","the","majority","of","cell","lines","studied",",","the","regulation","of","ferritin","expression","was","exerted","mostly","at","the","translational","level","."],"ner_tags":[0,0,0,0,5,6,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"15379","tokens":["In","transient","expression","and","in","vitro","degradation","experiments",",","the","stability","of","c-Fos","was","decreased","when","the","protein","was","dimerized","with","phosphorylated","c-Jun","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"4304","tokens":["In","selecting","the","most","specific","and","potent","oligonucleotide","sequence",",","we","performed","extensive","analyses","for","the","binding","specificity","between","all","candidates","of","c-jun","AS","oligonucleotides","and","the","whole","sequences","in","GenBank","database",",","using","a","computer","program","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16599","tokens":["1",",","25","(","OH",")","2D3","is","known","to","be","produced","at","sites","of","granulomatous","reactions","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2187","tokens":["This","protein",",","termed","calcium-signal","modulating","cyclophilin","ligand","(","CAML",")",",","acts","downstream","of","the","TCR","and","upstream","of","calcineurin","by","causing","an","influx","of","calcium","."],"ner_tags":[0,0,0,0,9,10,10,10,0,9,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"9057","tokens":["Two","peptides",",","P2","and","P8",",","induced","naive","T","cell","proliferation","less","effectively","and","were","also","less","immunogenic","for","T","cells","from","vaccinated","or","naturally","immune","donors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0]}
{"id":"838","tokens":["We","also","examined","whether","CBF","could","distinguish","a","1-bp","difference","between","the","enhancer","core","of","SL3","and","the","core","of","the","nonleukemogenic","virus",",","Akv","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"750","tokens":["Scatchard","analysis","of","glucocorticoid","receptor","-","GRE","binding","showed","no","change","in","binding","affinity","but","did","show","a","reduced","number","of","receptors","available","for","DNA","binding","in","the","steroid-resistant","patients","."],"ner_tags":[0,0,0,9,10,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"7312","tokens":["Oxidizing","agents","are","powerful","activators","of","factors","responsible","for","the","transcriptional","activation","of","cytokine-encoding","genes","involved","in","tissue","injury","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0]}
{"id":"13277","tokens":["Oestradiol","has","mitogenic","and","regulatory","effects","on","various","organs","and","cells",",","mediated","mainly","by","its","nuclear","receptor","(","ER",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0]}
{"id":"13100","tokens":["The","patient","was","a","phenotypic","female","with","late","onset","menarche","(","18","years","of","age",")",",","who","was","amenorrhoeic","for","the","first","year",",","followed","by","menses","of","one","to","three","days","'","slight","flow","with","dysmenorrhoea",",","but","an","otherwise","normal","menstrual","history","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4295","tokens":["The","regulation","of","transcription","factors","belonging","to","the","signal","transducer","and","activator","of","transcription","(","STAT",")","family","was","analyzed","in","PHA-activated","mononuclear","cells","and","in","purified","T","cells","activated","by","cross-linking","cell","surface","CD3","."],"ner_tags":[0,0,0,9,10,0,0,0,9,10,10,10,10,10,10,10,10,10,0,0,0,5,6,6,0,0,5,6,6,0,0,0,9,10,10,0]}
{"id":"17539","tokens":["The","difference","between","the","peak","(","0",":","00",")","and","trough","values","(","8",":","00",")","of","RM","and","ChtM","was","significant","statistically","(","P","less","than","0.01",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13386","tokens":["PPARgamma","has","also","been","implicated","recently","in","the","biology","of","monocytes","and","in","cell-cycle","regulation","and","cancer","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3969","tokens":["By","using","a","DNA","sequence","selected","for","its","ability","to","bind","recombinant","BCL-6","in","vitro",",","we","show","here","that","BCL-6","is","present","in","DNA-binding","complexes","in","nuclear","extracts","from","various","B-cell","lines","."],"ner_tags":[0,0,0,1,2,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,5,6,0]}
{"id":"6894","tokens":["Finally",",","soluble","CD4","(","sCD4",")","prevented","virus","reactivation","by","D1\/CDR2-loop","ligands","."],"ner_tags":[0,0,9,10,0,9,0,0,0,0,0,9,10,0]}
{"id":"7293","tokens":["GATA-1","and","erythropoietin","cooperate","to","promote","erythroid","cell","survival","by","regulating","bcl-xL","expression","."],"ner_tags":[9,0,9,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"16311","tokens":["The","transcription","factor","HIV-TF1",",","which","binds","to","a","region","about","60","bp","upstream","from","the","enhancer","of","the","human","immunodeficiency","virus-1","(","HIV-1",")",",","was","purified","from","human","B","cells","."],"ner_tags":[0,9,10,9,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"3797","tokens":["NGFI-B\/nur77","and","its","related","genes","constitute","a","family","and","the","NGFI-B\/nur77","family","consists","of","three","subtypes",",","named","nur77","alpha",",","nur77","beta",",","nur77","gamma","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,10,0,9,10,0,9,10,0]}
{"id":"15577","tokens":["Leukotriene","B4","transcriptionally","activates","interleukin-6","expression","involving","NK-chi","B","and","NF-IL6","."],"ner_tags":[0,0,0,0,9,0,0,9,10,0,9,0]}
{"id":"9617","tokens":["As","such",",","it","serves","as","an","excellent","paradigm","for","the","study","of","lineage","and","developmental","stage-specific","gene","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6075","tokens":["The","effect","of","IL-10","was","dose-dependent","with","a","maximum","stimulation","using","100","ng\/ml","of","IL-10","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"2371","tokens":["The","binding","sites","fulfil","the","required","criteria","for","specific","steroid","binding","sites","however","differ","somewhat","from","the","classic","androgen","receptors","from","genital","skin","fibroblast",":","in","fertile","adult","males","(","n","=","20",")","the","binding","sites","showed","(","1",")","a","high","affinity","for","testosterone","(","1.32","+\/-","0.49","nM",";","mean","+\/-","SD",")",",","(","2",")","a","saturable","capacity","(","184","+\/-","52","binding","sites","per","cell",";","mean","+\/-","SD",")",",","and","(","3",")","a","characteristic","competitive","binding","profile","for","other","steroid","hormones","(","relative","binding","affinities",":","testosterone","=","dihydrotestosterone",">","17","beta-estradiol",">","progesterone",",","whereas","aldosterone",",","17-hydroxy-progesterone","and","cortisol","did","not","compete","appreciably",")","."],"ner_tags":[0,9,10,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,9,10,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11240","tokens":["Impaired","induction","of","c-fos\/c-jun","genes","and","of","transcriptional","regulatory","proteins","binding","distinct","c-fos\/c-jun","promoter","elements","in","activated","human","T","cells","during","aging","."],"ner_tags":[0,0,0,1,2,0,0,9,10,10,0,0,1,2,2,0,7,8,8,8,0,0,0]}
{"id":"5874","tokens":["Furthermore",",","the","binding","of","both","forms","of","NFATp","to","calcineurin","was","inhibited","by","pretreatment","of","calcineurin","with","a","complex","of","FK506","and","its","ligand","FKBP12","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"9573","tokens":["We","now","report","on","the","transcription","factors","which","bind","and","transactivate","this","enhancer","sequence","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,1,2,0]}
{"id":"17438","tokens":["Here","we","report","the","presence","of","a","factor","with","the","mobility","and","sequence-specific","DNA-binding","characteristics","of","EF1","at","low","abundance","in","a","wide","variety","of","non-erythroid","cell","types","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"12339","tokens":["CD40","activation","of","B","cells","is","strongly","influenced","by","the","presence","of","cytokines","."],"ner_tags":[9,0,0,7,8,0,0,0,0,0,0,0,9,0]}
{"id":"4216","tokens":["Indeed",",","erythroid","gene","expression","was","demonstrated","to","be","regulated","transcriptionally","by","ACLA","and","mainly","posttranscriptionally","by","DOX","."],"ner_tags":[0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7707","tokens":["Nuclear","Factor","kappa","B","(","NFkappaB",")","is","a","critical","regulator","of","several","genes","involved","in","immune","and","inflammatory","responses","."],"ner_tags":[9,10,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1829","tokens":["However",",","sequence","specificity","of","NF-AT","was","more","similar","to","that","of","NF","(","P",")",",","and","only","a","small","amount","of","P65","was","detected","in","NF","(","P",")","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,9,0,0,0,9,10,10,10,0]}
{"id":"1077","tokens":["First",",","we","show","that","persistent","HIV","infection","results","in","the","activation","of","NF-kappa","B","not","only","in","monocytic","cells","but","also","in","macrophages","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"9637","tokens":["The","levels","of","the","apoptosis","effector","proteins","Bak","and","Bad","were","enhanced",",","whereas","there","was","a","slight","down-regulation","of","the","apoptosis","suppressor","protein","Bcl-2","after","treatment","of","the","cells","with","PDBu","and","DMSO","."],"ner_tags":[0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,9,10,10,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"7565","tokens":["Transient","transfection","of","endothelial","cells","with","ICAM-1","promoter","luciferase","reporter","gene","(","ICAM-1LUC",")","constructs","indicated","that","deletion","of","upstream","NF-kappa","B","site","(","-533","bases","from","translation","start","site",")","had","no","effect","on","thrombin","responsiveness",",","whereas","mutation\/deletion","of","downstream","NF-kappa","B","site","(","-223","bases","from","the","translation","start","site",")","prevented","the","activation","of","ICAM-1","promoter",",","indicating","that","the","downstream","NF-kappa","B","site","is","critical","for","thrombin","inducibility","."],"ner_tags":[0,0,0,7,8,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,1,2,2,0,1,2,0,1,2,2,0,0,0,0,0,9,0,0,0,0,0,0,1,2,2,0,1,2,0,0,1,2,2,0,0,0,0,0,1,2,0,0,0,0,0,1,2,2,0,0,0,9,0,0]}
{"id":"5427","tokens":["Activation","of","macrophages","by","bacterial","lipopolysaccharide","(","LPS",")","induces","transcription","of","genes","that","encode","for","proinflammatory","regulators","of","the","immune","response","."],"ner_tags":[0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"9382","tokens":["During","T","cell","differentiation",",","expression","peaked","in","the","actively","dividing","immature","single","positive","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,8,8,8,8,0]}
{"id":"9178","tokens":["Therefore","we","investigated","the","properties","and","function","of","the","glucocorticoid","receptors","(","GR",")","in","FMS","patients","and","compared","the","results","with","those","of","healthy","persons","and","patients","with","chronic","low","back","pain","(","LBP","a","localized","pain","condition",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17680","tokens":["Here","we","cloned","the","murine","BCL6","(","mBCL6",")","cDNA","from","the","muscle","cDNA","library","using","the","human","BCL6","(","hBCL6",")","cDNA","as","a","probe","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,0,0,1,2,2,0,0,1,2,2,2,2,2,0,0,0,0]}
{"id":"7055","tokens":["3.7","kilobases","upstream","of","the","murine","hematopoietic-specific","GATA-1","IE","promoter","."],"ner_tags":[0,0,0,0,0,1,2,2,2,2,0]}
{"id":"15218","tokens":["They","may","also","prove","useful","in","the","identification","of","new",",","ubiquitous","cellular","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"11704","tokens":["The","existence","of","alternative","Pax-5","transcripts","was","confirmed","using","RNase","protection","assays","."],"ner_tags":[0,0,0,0,3,4,0,0,0,9,0,0,0]}
{"id":"10756","tokens":["CIITA","is","a","positive","regulator","of","class","II","major","histocompatibility","complex","gene","transcription","that","has","been","found","to","be","defective","in","one","of","the","five","complementation","groups","of","class","II","major","histocompatibility","complex-negative","cell","lines","."],"ner_tags":[9,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,0]}
{"id":"17473","tokens":["These","results","suggest","that","OTF-1",",","without","OTF-2",",","is","sufficient","for","transcription","of","immunoglobulin","genes","and","that","OTF-2","alone","is","not","responsible","for","the","B-cell-specific","regulation","of","immunoglobulin","gene","expression","."],"ner_tags":[0,0,0,0,9,0,0,9,0,0,0,0,0,0,1,2,0,0,9,0,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"17478","tokens":["A","decrease","of","intracellular","sodium","or","potassium","occurred","during","incubation","without","aldosterone","(","P","less","than","0.02",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7434","tokens":["NF-kappaB","regulates","Fas\/APO-1\/CD95-","and","TCR-","mediated","apoptosis","of","T","lymphocytes","."],"ner_tags":[9,0,0,0,0,0,0,0,7,8,0]}
{"id":"12301","tokens":["CD2",",","but","not","CD3",",","cross-linking","increased","cAMP","detected","by","competitive","enzyme-linked","immunosorbent","assay","(","ELISA",")","approximately","fourfold","."],"ner_tags":[9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16024","tokens":["It","contributes","to","virus-induced","erythroleukemia","by","efficiently","arresting","differentiation","of","red","cell","progenitors","and","by","suppressing","transcription","of","erythrocyte-specific","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,1,2,0]}
{"id":"11211","tokens":["Using","the","yeast","two-hybrid","system","to","screen","for","proteins","which","interact","with","Tax1",",","we","isolated","the","B","subunit","of","the","CCAAT","binding","protein","NF-Y","from","a","HeLa","cDNA","library","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,10,0,0,9,10,10,9,0,0,1,2,2,0]}
{"id":"5131","tokens":["Of","these",",","11","were","found","to","possess","DNA-binding","properties","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7024","tokens":["These","results","suggest","a","key","functional","role","of","PML","in","early","hematopoiesis","and","late","erythropoiesis",":","the","latter","phenomenon","may","be","related","to","the","molecular","and","functional","interaction","of","PML","with","pRb","105","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0]}
{"id":"15631","tokens":["A","lowered","affinity","to","dexamethasone","was","found","in","one","female","patient",",","while","a","lowered","number","of","receptors","was","found","in","three","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15110","tokens":["3","."],"ner_tags":[0,0]}
{"id":"12552","tokens":["Unexpectedly",",","the","CD4","silencer","is","also","active","in","CD4+","CD8int\/-","cells","of","the","thymus",",","implying","that","an","anti-silencer","may","be","required","to","resume","CD4","expression","in","this","cell","population","."],"ner_tags":[0,0,0,1,2,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"5812","tokens":["Lastly",",","we","demonstrate","a","selective","inhibition","of","p24","production","by","HIV-infected","human","macrophages","when","treated","with","AO","to","PKC-zeta","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,7,8,8,0,0,0,0,0,9,0]}
{"id":"4691","tokens":["The","activation","of","T","cells","requires","engagement","of","the","T","cell","receptor\/CD3","complex","and","co-stimulatory","molecules",",","and","results","in","the","triggering","of","several","signaling","pathways","which","lead","rapidly","to","the","nuclear","translocation","of","several","transcription","factors",",","such","as","nuclear","factor","(","NF",")","-kappa","B","and","NF-AT","."],"ner_tags":[0,0,0,7,8,0,0,0,0,9,10,10,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,10,10,10,10,0,9,0]}
{"id":"2875","tokens":["The","restricted","pattern","of","SCL","protein","synthesis","is","consistent","with","the","restricted","expression","of","SCL","mRNA","documented","previously","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,3,4,0,0,0]}
{"id":"17240","tokens":["Proliferation","and","immunologic","function","of","T","lymphocytes","are","initiated","by","signals","from","the","antigen","receptor","that","are","inhibited","by","the","immunosuppressant","FK506","but","not","by","its","structural","analog",",","rapamycin","."],"ner_tags":[0,0,0,0,0,7,8,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12671","tokens":["We","show","here","that","IFN-alpha\/beta","act","directly","on","human","T","cells","to","drive","Th1","development",",","bypassing","the","need","for","IL-12","-induced","signaling",",","whereas","IFN-alpha","can","not","substitute","IL-12","for","mouse","Th1","development","."],"ner_tags":[0,0,0,0,9,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,9,0,0,0,0,9,0,0,0,9,0,0,0,0,0]}
{"id":"12156","tokens":["We","show","that",",","whereas","a","multimerized","response","element","from","the","germline","IgE","promoter","was","highly","induced","by","IL-4","in","Stat6-expressing","Jurkat","cells",",","the","intact","human","IL-4","promoter","was","repressed","under","similar","conditions","."],"ner_tags":[0,0,0,0,0,0,1,2,2,0,0,1,2,2,0,0,0,0,9,0,7,8,8,0,0,0,1,2,2,0,0,0,0,0,0]}
{"id":"11214","tokens":["We","also","show","that","in","vitro-translated","NF-YB","specifically","bound","to","a","glutathione","S-transferase-Tax1","fusion","protein","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,9,10,10,10,0]}
{"id":"13654","tokens":["Structural","analysis","demonstrated","that","the","mouse","CPO","gene","spans","approximately","11","kb","and","consists","of","seven","exons",",","just","like","its","human","counterpart","."],"ner_tags":[0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0]}
{"id":"9515","tokens":["Copyright","1997","Academic","Press","."],"ner_tags":[0,0,0,0,0]}
{"id":"3992","tokens":["Dexamethasone","suppression","test",":","corticosteroid","receptors","regulation","in","mononuclear","leukocytes","of","young","and","aged","subjects","."],"ner_tags":[0,0,0,0,9,10,0,0,7,8,0,0,0,0,0,0]}
{"id":"16029","tokens":["Likewise",",","T3","activated","CAII","transcription","as","well","as","transient","expression","of","a","T3-responsive","reporter","gene","containing","the","CAII-specific","erbA-binding","site","."],"ner_tags":[0,0,0,0,1,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0]}
{"id":"4429","tokens":["Acute","promyelocytic","leukemia","(","APL",")","is","a","specific","type","of","acute","myeloid","leukemia","characterized","by","the","morphology","of","the","blast","cells",",","a","specific","t","(","15",";","17",")","translocation",",","and","risks","of","definite","coagulopathy","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6883","tokens":["These","cells","had","properties","of","both","natural","killer","(","NK",")","and","pre-T","cells","."],"ner_tags":[0,0,0,0,0,0,7,8,0,7,0,0,7,8,0]}
{"id":"12387","tokens":["Hence",",","these","cytokines","do","not","simply","enhance","monocyte","differentiation",",","but","have","complex","and","slightly","divergent","effects","that","impact","on","HIV","replication","probably","through","cell","signaling","pathways","and","nuclear","factor-kappaB","translocation","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"13295","tokens":["We","also","examined","the","possibility","that","Akt\/PKB","is","regulated","by","Ras","signaling","pathways","in","T","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,7,8,0]}
{"id":"2800","tokens":["The","present","review","summarizes","these","findings",",","with","a","special","focus","on","our","own","studies","on","pluripotent","endocrine","cultures","of","rat","pancreas","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0]}
{"id":"1884","tokens":["RESULTS",":","BZLF1","(","ZEBRA",")","or","early","gene","products","(","EA-R","and","EA-D\/BHLF1\/NotI",")","were","detected","in","a","small","proportion","(","<","0.01-5","%",")","of","tumour","cells","in","eight","of","these","17","cases","by","immunohistochemistry","and","in","situ","hybridization","."],"ner_tags":[0,0,9,0,9,0,0,9,10,10,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7294","tokens":["The","transcription","factor","GATA-1","is","essential","for","normal","erythropoiesis","."],"ner_tags":[0,9,10,9,0,0,0,0,0,0]}
{"id":"11940","tokens":["Both","MAP","ERK","kinase","kinase-1","(","MEKK1",")","and","Raf","are","activated","strongly","by","FMLP",",","but","minimally","by","PAF","."],"ner_tags":[0,9,10,10,10,0,9,0,0,9,0,0,0,0,9,0,0,0,0,9,0]}
{"id":"18085","tokens":["One","of","these","enhancers","is",",","in","part",",","identical","to","the","HIV-1","enhancer","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"5181","tokens":["Pretreatment","with","B.pertussis",",","V.cholera.","or","C.botulinum","toxin","did","not","influence","histamine-induced","[","Ca2+","]","i","rise","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2175","tokens":["Most","of","these","cells","have","rearranged","their","heavy-chain","locus","but","not","their","light","chain","genes",",","suggesting","that","an","active","v-abl","protein","interferes","with","this","differentiation","step","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,1,2,2,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"17366","tokens":["The","amino","terminus","contains","an","unusual","repeat","of","38","consecutive","glutamine","residues","and","an","X-Thr-Pro","repeat","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"16448","tokens":["An","almost","identical","reaction","was","obtained","when","tumor","cells","from","malignant","effusions","were","tested","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"15685","tokens":["Two","subclones","were","found","to","have","an","abnormal","response","to","the","protein","kinase","C","(","PKC",")","activator","PMA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0]}
{"id":"13880","tokens":["We","conclude","that",":","(","i",")","suppression","of","specific","transcription","factor","functions","can","potentially","serve","as","a","marker","of","exposure","to","oxidative","stress","and","its","effects","on","human","lymphocytes",";","(","ii",")","lipid","peroxidation","is","only","detectable","in","human","lymphocytes","upon","exposure","to","weak","oxidative","stress","which","does","not","induce","catalase","activity",";","(","iii",")","therefore",",","transcription","factor","DNA-binding","activities","are","more","sensitive","to","oxidative","stress","than","lipid","peroxidation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"517","tokens":["Four","distinct","complementation","groups","have","been","identified","."],"ner_tags":[0,0,0,0,0,0,0,0]}
{"id":"17697","tokens":["As","occurs","for","HSF1",",","heat","shock","leads","to","the","translocation","of","HSF3","to","the","nucleus","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"6874","tokens":["Treatment","of","HCD57","cells","with","SCF","also","activated","PKB\/Akt",",","but","did","not","protect","from","apoptosis","."],"ner_tags":[0,0,5,6,0,9,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"7787","tokens":["GrpL","can","be","coimmunoprecipitated","with","SLP-76","but","not","with","Sos1","or","Sos2","from","Jurkat","cell","lysates","."],"ner_tags":[9,0,0,0,0,9,0,0,0,9,0,9,0,5,6,0,0]}
{"id":"10443","tokens":["These","results","provide","new","evidence","for","a","possible","relationship","between","the","activation","of","the","electron-transport","system","at","the","plasma","membrane","by","ascorbate","or","its","free","radical","and","redox-dependent","gene","transcription","in","T-cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"10513","tokens":["Electrophoretic","mobility-shift","assays","of","HUVEC","nuclear","proteins","revealed","a","decrease","in","TNF-alpha-stimulated","nuclear","factor-kappa","B","(","NF-kappa","B",")","activation","after","pretreatment","of","HUVEC","with","TCP","succinate","but","not","with","TCP",",","TCP","acetate",",","or","succinate","alone","."],"ner_tags":[0,0,0,0,5,9,10,0,0,0,0,9,10,10,10,0,9,10,0,0,0,0,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10191","tokens":["In","addition",",","in","vivo","footprint","analysis","showed","the","putative","X","and","Y","boxes","to","be","occupied","by","transcription","factors","in","wild-type","B","cells",",","but","not","in","RFX-deficient","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,9,10,0,7,8,8,0,0,0,0,5,6,6,0]}
{"id":"9712","tokens":["In","the","present","report",",","we","studied","the","role","of","the","stromal-derived","cytokine","interleukin-7","(","IL-7",")","in","the","IL-2-gene","regulation","in","activated","T","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,1,0,0,7,8,8,0]}
{"id":"676","tokens":["This","factor","was","designated","IL-4","NAF","(","IL-4-induced","nuclear-activating","factors",")","and","was","identified","as","a","tyrosine","phosphoprotein",",","which","translocates","from","the","cytosol","to","the","nucleus","upon","IL-4","treatment","."],"ner_tags":[0,0,0,0,9,10,0,9,10,10,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"16701","tokens":["Studies","of","the","actions","of","platelet-activating","factor","have","centered","mainly","around","neutrophils",",","monocytes",",","and","platelets","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,7,0,7,0,0,7,0]}
{"id":"1677","tokens":["Correlation","of","differentiation-inducing","activity","of","retinoids","on","human","leukemia","cell","lines","HL-60","and","NB4","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,6,5,0,5,0]}
{"id":"7876","tokens":["Thus",",","inhibition","of","GSK-3beta","is","insufficient","to","activate","Tcf-dependent","transcription","in","T","lymphocytes","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,7,8,0]}
{"id":"12521","tokens":["Differential","activation","of","functionally","distinct","STAT5","proteins","by","IL-5","and","GM-CSF","during","eosinophil","and","neutrophil","differentiation","from","human","CD34+","hematopoietic","stem","cells","."],"ner_tags":[0,0,0,0,0,9,10,0,9,0,9,0,0,0,0,0,0,5,6,6,6,6,0]}
{"id":"145","tokens":["H-89","substantially","suppressed","LPS-induced","TNF","mRNA","accumulation","in","unprimed","cells",",","but","had","no","effect","on","primed","monocytes","following","LPS","stimulation","."],"ner_tags":[0,0,0,0,3,4,0,0,5,6,0,0,0,0,0,0,5,6,0,0,0,0]}
{"id":"17811","tokens":["Thus","two","different","anti-onco-genic","transcription","factors",",","p53","and","IRF-1",",","are","required","for","distinct","apoptotic","pathways","in","T","lymphocytes","."],"ner_tags":[0,0,0,9,10,10,0,9,0,9,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"11609","tokens":["The","role","of","mitogen-activated","protein","kinase","(","MAPK",")","pathway","on","TCC","-inducible","mitotic","signaling","was","evaluated","by","assessing","DNA","synthesis","and","activator","protein","1","(","AP-1",")","DNA-binding","activity","."],"ner_tags":[0,0,0,9,10,10,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0]}
{"id":"4712","tokens":["Active","Raf-1","phosphorylates","and","activates","the","mitogen-activated","protein","(","MAP",")","kinase\/extracellular","signal-regulated","kinase","kinase","1","(","MEK1",")",",","which","in","turn","phosphorylates","and","activates","the","MAP","kinases\/extracellular","signal","regulated","kinases",",","ERK1","and","ERK2","."],"ner_tags":[0,9,0,0,0,0,9,10,10,10,10,10,10,10,10,10,0,9,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,9,0,9,0]}
{"id":"150","tokens":["Using","biochemical","and","mutagenesis","analyses",",","we","determined","that","multiple","nuclear","factors","bind","to","these","independent","sites","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"14984","tokens":["The","detection","of","this","protein","selectively","in","extracts","of","lymphoid","cells","correlates","with","the","presence","of","the","E","box","-binding","activity","LEF1\/BCF1","in","these","cells",";","this","binding","activity","was","previously","shown","to","be","efficiently","recognized","by","antiserum","directed","against","E2A","gene","products","."],"ner_tags":[0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,1,2,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"12554","tokens":["[","Induction","of","apoptosis","in","lymphocytes","by","glucocorticoids",":","between","physiology","and","pharmacology","]"],"ner_tags":[0,0,0,0,0,7,0,0,0,0,0,0,0,0]}
{"id":"16711","tokens":["A","new","B-cell-specific","enhancer","element","has","been","identified","3","'","of","E4","and","the","octamerlike","motifs","in","the","human","immunoglobulin","heavy-chain","gene","enhancer","."],"ner_tags":[0,0,1,2,2,0,0,0,0,0,0,1,2,2,2,2,0,0,1,2,2,2,2,0]}
{"id":"6462","tokens":["The","presence","of","C\/EBP","beta","was","confirmed","by","immunohistochemistry","and","Western","blot","analysis","with","isolated","synovial","fibroblasts","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"6420","tokens":["The","generation","of","cell-mediated","immunity","against","many","infectious","pathogens","involves","the","production","of","interleukin-12","(","IL-12",")",",","a","key","signal","of","the","innate","immune","system","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1776","tokens":["In","a","NGF-responsive","rat","pheochromocytoma","cell","line",",","PC12",",","PMA","activated","NF-kappa","B",",","whereas","NGF","did","not","."],"ner_tags":[0,0,5,6,6,6,6,0,5,0,0,0,9,10,0,0,9,0,0,0]}
{"id":"10505","tokens":["The","adherence","of","monocytes","to","activated","endothelium","is","an","early","event","in","atherogenesis","."],"ner_tags":[0,0,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"18432","tokens":["By","combining","partially","purified","proteins","in","vitro",",","we","observed","the","loss","of","the","bound","NFATp\/AP-1-DNA","complex","upon","inclusion","of","VDR","or","VDR-retinoid","X","receptor","."],"ner_tags":[0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,0,9,10,10,0]}
{"id":"10937","tokens":["In","vitro",",","thrombin-stimulated","fixed","platelets","bound","to","neutrophils","and","monocytes","."],"ner_tags":[0,0,0,7,8,8,0,0,7,0,7,0]}
{"id":"13855","tokens":["We","report","here","that","monocytes\/macrophages","in","human","atherosclerotic","lesions","(","n","=","12",")","express","immunostainable","PPARgamma","."],"ner_tags":[0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"827","tokens":["The","core","elements","of","the","SL3","virus","are","important","genetic","determinants","of","the","ability","of","this","virus","to","induce","T-cell","lymphomas","and","the","transcriptional","activity","of","the","viral","long","terminal","repeat","in","T","lymphocytes","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,7,8,0]}
{"id":"18248","tokens":["CD30","ligation","induces","nuclear","factor-kappa","B","activation","in","human","T","cell","lines","."],"ner_tags":[9,0,0,9,10,10,0,0,5,6,6,6,0]}
{"id":"11212","tokens":["The","interaction","of","Tax1","with","NF-YB","was","specific","in","that","NF-YB","did","not","interact","with","a","variety","of","other","transcription","factors",",","including","human","immunodeficiency","virus","Tat",",","human","papillomavirus","E6",",","and","Bicoid",",","or","with","the","M7","(","amino","acids","29CP-AS",")","Tax1","mutant","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0,0,9,10,10,10,0,9,10,10,0,0,9,0,0,0,0,9,10,10,10,10,10,10,10,0]}
{"id":"4903","tokens":["Interferon-gamma","(","IFN-gamma",")","modulates","the","expression","of","several","cytokines","by","human","monocytes","at","the","transcriptional","level","."],"ner_tags":[9,0,9,0,0,0,0,0,0,9,0,7,8,0,0,0,0,0]}
{"id":"12095","tokens":["Deregulated","TCR","-mediated","responses","and","the","fast","kinetics","of","tumor","development","in","these","mutant","thymocytes","implicate","Ikaros","as","a","central","tumor","suppressor","gene","for","the","T","cell","lineage","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,1,2,2,2,0,0,7,8,8,0]}
{"id":"15433","tokens":["The","P","sequence","was","located","between","positions","-79","and","-69","relative","to","the","transcription","start","site","of","the","human","IL-4","gene",",","and","this","location","was","confirmed","by","base-substitution","mutations","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"14599","tokens":["Transfection","studies","reveal","that","the","I","kappa","B-alpha","mRNA","and","the","encoded","protein","are","potently","induced","by","NF-kappa","B","and","by","homodimers","of","p65","and","of","c-Rel","."],"ner_tags":[0,0,0,0,0,3,4,4,4,0,0,0,0,0,0,0,0,9,10,0,0,0,0,9,0,0,9,0]}
{"id":"10366","tokens":["ETS1",",","NFkappaB","and","AP1","synergistically","transactivate","the","human","GM-CSF","promoter","."],"ner_tags":[9,0,9,0,9,0,0,0,1,2,2,0]}
{"id":"756","tokens":["IL-5","induced","rapid","and","transient","tyrosine","phosphorylation","of","JAK2","."],"ner_tags":[9,0,0,0,0,0,0,0,9,0]}
{"id":"2047","tokens":["Base-pair","substitutions","in","the","TF","site","indicated","that","the","presence","of","a","cytosine","at","position","1","precluded","binding","of","NF-kappa","B","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,0]}
{"id":"5282","tokens":["Upon","stimulation",",","they","express","high","levels","of","secreted","heat","stable","placental","alkaline","phosphatase","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"14173","tokens":["Characterization","of","the","nuclear","and","cytoplasmic","components","of","the","lymphoid-specific","nuclear","factor","of","activated","T","cells","(","NF-AT",")","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,7,8,8,0,9,0,0,0]}
{"id":"10702","tokens":["ZEBRA","activation","domain","swap","constructs","retain","ZEBRA","'s","native","abilities","to","activate","specific","EBV","promoters",",","to","disrupt","EBV","latency",",","and","to","stimulate","replication","at","the","EBV","lytic","origin","."],"ner_tags":[9,0,0,0,0,0,9,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"10487","tokens":["Emphasis","is","placed","on","cytokines","that","have","been","studied","in","periodontitis",",","principally","TNF-alpha",",","IL-1",",","IL-6",",","IL-8","and","beta-interferon","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,9,0,9,0,9,0,9,0]}
{"id":"1796","tokens":["Purification","and","cloning","of","this","protein",",","termed","early","B-cell","factor","(","EBF",")",",","from","murine","B","lymphocytes","and","independent","cloning","of","a","protein",",","termed","Olf-1",",","from","olfactory","neuronal","cells","revealed","virtual","complete","amino","acid","sequence","identity","between","these","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,7,8,8,0,0,0,0,0,0,0,0,9,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5715","tokens":["Using","a","novel","flow-cytometric","assay",",","we","were","able","to","identify","CD8","(","+",")","-T-cell","epitopes","(","by","IE-1","peptide-specific","induction","of","cytokine","synthesis",")","and","simultaneously","measure","the","frequency","of","cells","directed","against","them","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2444","tokens":["Northern","analysis","of","mRNA","from","hypoxic","ECs","also","demonstrated","increased","levels","of","mRNA","for","macrophage","chemotactic","protein-1",",","another","member","of","the","chemokine","superfamily","of","proinflammatory","cytokines","."],"ner_tags":[0,0,0,0,0,0,7,0,0,0,0,0,3,0,9,10,10,0,0,0,0,0,9,10,0,9,10,0]}
{"id":"11521","tokens":["On","the","other","hand",",","a","decline","of","the","arsenic","content","in","hair","and","nail","was","observed","after","withdrawal","of","the","drug","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11033","tokens":["Rabbit","antiserum","raised","against","a","COOH-terminal","polypeptide","of","the","SRG3","recognized","a","protein","with","an","apparent","molecular","mass","of","155","kD","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3489","tokens":["Moreover",",","TCR","-induced","phosphorylation","of","pp36-38",",","thought","to","play","a","role","upstream","of","these","pathways",",","was","found","to","be","reduced","."],"ner_tags":[0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2529","tokens":["The","induced","expression","of","IL-1","beta","and","TNF","alpha","mRNA","in","the","monocytic","THP-1","cell","line","increased","as","quickly","as","in","primary","cells","."],"ner_tags":[0,0,0,0,3,4,4,4,4,4,0,0,0,5,6,6,0,0,0,0,0,7,8,0]}
{"id":"6652","tokens":["In","contrast","to","neutrophils",",","p38","was","constitutively","phosphorylated","and","agonist-dependent","phosphorylation","and","activation","was","not","detected","in","human","monocytes","."],"ner_tags":[0,0,0,7,0,9,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"12186","tokens":["Activation","of","signaling","pathways","and","prevention","of","apoptosis","by","cytokines","in","eosinophils","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,7,0]}
{"id":"9739","tokens":["Finally",",","a","110-kDa","protein","has","been","identified","in","the","nuclei","of","all","the","B",",","but","not","T",",","cell","lines","that","specifically","binds","to","this","A-MYB","N-terminal","domain","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,5,6,6,6,6,6,6,6,0,0,0,0,0,9,10,10,0]}
{"id":"3211","tokens":["IL-2","induced","the","binding","of","Stat5a","and","b","proteins","to","the","human","GASd","element","."],"ner_tags":[9,0,0,0,0,9,10,10,10,0,0,1,2,2,0]}
{"id":"13568","tokens":["We","describe","the","embryonic","expression","of","musculin",",","a","new","murine","member","of","the","bHLH","family","of","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,0,9,10,0]}
{"id":"9258","tokens":["Modulation","of","mRNA","expression","of","a","novel","human","myeloid-selective","CCAAT\/enhancer","binding","protein","gene","(","C\/EBP","epsilon",")","."],"ner_tags":[0,0,0,0,0,0,1,2,2,2,2,2,2,0,1,2,0,0]}
{"id":"4265","tokens":["Mature","human","lymphocytes","are","unique","targets","of","1","alpha",",","25-dihydroxyvitamin","D3","(","1","alpha",",","25","(","OH",")","2D3",")","in","that","vitamin","D","receptors","(","VDR",")","are","not","constitutively","expressed",",","and","specific","cellular","activation","signals","are","required","for","both","the","up-regulation","of","VDR","and","establishment","of","reactivity","to","the","lipophilic","ligand","."],"ner_tags":[0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"4571","tokens":["Our","data","suggest","that","IL-13","utilizes","IL-4R","and","its","signaling","pathway",",","and","JAK2","may","play","an","important","role","in","the","function","of","IL-4R","and","IL-13R","in","colon","cancer","cells","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,7,8,8,0]}
{"id":"16705","tokens":["We","also","show","that","platelet-activating","factor","from","10","(","-12",")","to","10","(","-6",")","M","induced","rapid","and","significant","elevation","in","intracellular","calcium","levels",",","whereas","lyso-","platelet-activating","factor","was","again","ineffective","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"5952","tokens":["In","addition",",","stimulation","with","MBP","prolonged","the","stability","of","IL-8","mRNA","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,3,4,0]}
{"id":"12884","tokens":["In","addition",",","IL-6","and","IL-2","synergistically","induce","homo-","and","heterodimerized","STAT1","alpha","and","STAT3","in","both","NK","and","T","cells",",","consistent","with","their","reported","synergism","in","modulating","perforin","gene","expression","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,9,10,0,9,0,0,7,8,8,8,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"10816","tokens":["Inducible","expression","and","phosphorylation","of","coactivator","BOB.1\/OBF.1","in","T","cells","[","see","comments","]"],"ner_tags":[0,0,0,0,0,9,10,0,7,8,0,0,0,0]}
{"id":"6948","tokens":["We","have","carried","out","a","detailed","analysis","of","the","cellular","immune","functions","of","breast","cancer","patients","in","comparison","with","healthy","controls","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11362","tokens":["We","show","that","engagement","of","CD40","induces","tyrosine","phosphorylation","and","activation","of","Jak3","as","well","as","of","STAT3","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,0,0,9,0]}
{"id":"12722","tokens":["We","conclude","that","sodium","phenylacetate","treatment","of","K562","cells","increases","gamma-globin","mRNA","and","induces","cell","maturation","as","judged","by","morphology","without","affecting","the","expression","of","the","erythroid","transcription","factors",",","some","of","which","are","known","to","be","involved","in","the","regulation","of","beta-like","globin","genes","."],"ner_tags":[0,0,0,0,0,0,0,5,6,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"16575","tokens":["The","numbers","of","estrogen","receptor","(","ER",")","in","human","peripheral","leucocytes","in","22","women","with","climacteric","syndrome","were","measured","by","radioligand","method","."],"ner_tags":[0,0,0,9,10,0,9,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9489","tokens":["In","cells","that","have","been","preincubated","to","lower","mRNA","levels",",","there","is","a","transient","increase","in","G0S2","mRNA",",","peaking","between","1-2","h",",","in","response","to","Concanavalin-A","(","ConA",")",",","or","to","the","combination","of","phorbol","ester","(","TPA",")",",","and","the","calcium","ionophore",",","ionomycin","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11909","tokens":["The","complex","network","of","cytokines","that","are","involved","in","inflammatory","and","immunoregulatory","responses","plays","a","critical","role","in","the","pathogenesis","of","HIV","infection","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5907","tokens":["Human","T-cell","lymphotropic","virus","I","(","HTLV-I",")","encodes","for","a","40-kDa","protein",",","Tax",",","which","is","important","for","the","immortalization","of","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"9067","tokens":["Moreover",",","IL-10","effects","on","the","early","G1","proteins","p27","(","Kip1",")","and","cyclin","D2","were","similarly","reversed","by","exogenous","IL-2","."],"ner_tags":[0,0,9,0,0,0,9,10,10,9,10,10,10,0,9,10,0,0,0,0,0,9,0]}
{"id":"15537","tokens":["CsA","was","found","not","to","inhibit","lck","gene","expression",",","nor","the","activity","of","the","lck","gene","product","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"1601","tokens":["A","unique","region","containing","four","or","five","near-perfect","direct","repeats","(","DR",")","of","21","bp","with","one","12-bp","insert","was","proven","to","be","the","main","transcription-activation","element",",","with","enhancer-like","characteristics","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,1,2,0,0,0,0,0]}
{"id":"11334","tokens":["We","have","previously","identified","an","enhancer","element",",","PRE-I",",","that","is","essential","for","the","function","of","the","human","IL-4","promoter","."],"ner_tags":[0,0,0,0,0,1,2,0,1,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"5364","tokens":["Therefore",",","this","oriP","contains","novel","elements","distinct","from","those","of","other","DNA","viruses","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4424","tokens":["The","induction","of","AP-1","by","p21ras","also","requires","Rac-1","function","."],"ner_tags":[0,0,0,9,0,9,0,0,9,0,0]}
{"id":"11349","tokens":["Experimental","expression","in","mice","and","spontaneous","expression","in","human","SLE","of","polyomavirus","T-antigen","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"17643","tokens":["Ras-related","GTP-binding","proteins","and","leukocyte","signal","transduction","."],"ner_tags":[9,10,10,0,7,0,0,0]}
{"id":"10167","tokens":["Thus",",","Sp1","and","Egr-1","physically","and","functionally","cooperate","to","mediate","maximal","IL-2Rbeta","promoter","activity","."],"ner_tags":[0,0,9,0,9,0,0,0,0,0,0,0,1,2,0,0]}
{"id":"2466","tokens":["A","second","feature","of","senescent","T","cells","is","the","dramatic","reduction","in","hsp70","production","in","response","to","heat","shock","."],"ner_tags":[0,0,0,0,5,6,6,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"6528","tokens":["These","results","suggest","that","NF-kappaB","activation","is","required","for","C5a-induced","IL-8","gene","expression","and","that","this","response","is","mediated","primarily","through","a","pertussis","toxin-insensitive","pathway","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15107","tokens":["In","order","to","further","understand","the","apparent","glucocorticoid","resistance","in","major","depressive","disorder",",","circadian","variation","in","cortisol","concentration",",","dexamethasone","suppression","and","glucocorticoid","receptor","binding","in","mononuclear","leukocytes",",","polymorphonuclear","leukocytes","and","cultured","skin","fibroblasts","were","measured","in","rigidly","defined","major","depressive","disorder","patients","and","non-depressed","psychiatric","controls","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,8,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2147","tokens":["Internal","ribosomal","binding","requires","a","cis-acting","element","termed","the","internal","ribosomal","entry","site","(","IRES",")","."],"ner_tags":[0,0,0,0,0,1,2,0,0,1,2,2,2,0,1,0,0]}
{"id":"14799","tokens":["We","propose","a","model","in","which","binding","of","a","myeloid-specific","factor","(","PU.1",")","allows","a","general","factor","(","Sp1",")","to","bind","in","a","tissue-specific","fashion","thereby","contributing","to","the","myeloid-specific","expression","of","CD11b","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0]}
{"id":"5942","tokens":["Furthermore",",","expression","of","physiological","levels","of","Bcl-x","protected","B","cells","from","Fas-mediated","apoptosis","in","the","absence","of","NF-kappaB","signaling","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,8,0,0,0,0,0,0,0,9,0,0]}
{"id":"6394","tokens":["Exposure","to","LPS","or","TNF","led","to","differential","patterns","of","IkappaB-alpha","and","IkappaB-epsilon","disappearance","from","and","reassembly","with","the","signalsome",",","whereas","IKK-alpha",",","IKK-beta",",","and","NIK","remained","complex-associated","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,0,0,0]}
{"id":"15079","tokens":["Values","were","compared","with","those","of","patients","with","benign","tumors","(","n","=","4",")",",","or","undergoing","a","mammary","reduction","(","n","=","7",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9360","tokens":["It","was","recently","shown","by","us","that","the","protein","is","located","in","germinal","center","B","cells","and","their","neoplastic","counterparts","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0,0,7,8,0]}
{"id":"1698","tokens":["In","this","study",",","we","demonstrate","that","nuclear","factor","(","NF",")","-kappa","B","and","NF-kappa","B-like","transcription","factors","are","activated","after","cross-linking","CD40","on","resting","human","tonsillar","B","cells","and","on","B","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,10,10,10,0,9,10,10,10,0,0,0,0,9,0,0,7,8,8,8,0,0,5,6,6,0]}
{"id":"16774","tokens":["NF-kappa","B","activation","by","tumor","necrosis","factor","alpha","in","the","Jurkat","T","cell","line","is","independent","of","protein","kinase","A",",","protein","kinase","C",",","and","Ca","(","2+",")","-regulated","kinases","."],"ner_tags":[9,10,0,0,9,10,10,10,0,0,5,6,6,6,0,0,0,9,10,10,0,9,10,10,0,0,9,10,10,10,10,10,0]}
{"id":"17932","tokens":["We","investigated","the","molecular","basis","of","the","synergistic","induction","by","interferon-gamma","(","IFN-gamma",")","\/","tumor","necrosis","factor-alpha","(","TNF-alpha",")","of","human","interleukin-6","(","IL-6",")","gene","in","THP-1","monocytic","cells",",","and","compared","it","with","the","basis","of","this","induction","by","lipopolysaccharide","(","LPS",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,10,10,0,9,0,0,1,2,2,2,2,2,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2818","tokens":["Taken","together",",","these","results","provide","a","new","aspect","to","our","knowledge","of","monocyte","differentiation","and","provide","evidence","that","human","monocytes","are","flexible","in","their","differentiation","potential","and","are","precursors","not","only","of","macrophages","but","also","of","CD1+relB+DC","and","TRAP-positive","MGC","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,7,0,7,8,0]}
{"id":"16586","tokens":["In","addition",",","cell-free","synthesized","hGR","was","capable","of","specific","binding","to","glucocorticoid","response","element","(","GRE",")","-containing","DNA","fragments","."],"ner_tags":[0,0,0,9,10,10,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,0]}
{"id":"16019","tokens":["In","human","histiocytic","U937","cells","mRNA","of","clone","pAT","133","was","constitutively","expressed",",","whereas","mRNA","of","pAT","225\/EGR1","was","induced","upon","induction","of","terminal","differentiation","."],"ner_tags":[0,3,4,4,4,4,0,0,0,0,0,0,0,0,0,3,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"7666","tokens":["Inhibition","of","STAT6","activity","is","not","evident","unless","cells","are","preincubated","with","IFN","for","at","least","1","h","before","IL-4","stimulation","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0]}
{"id":"6301","tokens":["Electrophoretic","mobility","gel","shift","assay","also","showed","a","reduction","in","the","binding","of","a","transcription","factor","to","the","MSR","promoter","AP-1\/ets","elements","in","IL-6","-treated","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,1,2,2,2,0,9,0,0,0]}
{"id":"16277","tokens":["These","results","suggest","that","expression","of","c-jun",",","jun","B","and","jun","D","genes","might","be","involved","in","terminal","granulocyte","differentiation","or","in","regulating","granulocyte","functionality","."],"ner_tags":[0,0,0,0,0,0,1,0,1,2,0,1,2,2,0,0,0,0,7,8,0,0,0,0,7,0,0]}
{"id":"8716","tokens":["The","molecular","basis","for","increased","IL-4","gene","expression","in","atopy","is","not","fully","understood","."],"ner_tags":[0,0,0,0,0,1,2,0,0,0,0,0,0,0,0]}
{"id":"4344","tokens":["These","results","suggest","that","oxidative","signals","can","positively","and","negatively","regulate","T","cell","transcriptional","events","and","that","changes","in","cellular","redox","can","uncouple","AP-1","regulation","of","c-jun","from","transcriptional","up-regulation","of","IL-2","via","NF-AT","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,9,0,0,1,0,0,0,0,9,0,9,0]}
{"id":"17337","tokens":["Oncogene","amplification","correlates","with","dense","lymphocyte","infiltration","in","human","breast","cancers",":","a","role","for","hematopoietic","growth","factor","release","by","tumor","cells","?"],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,7,8,0]}
{"id":"16958","tokens":["Pseudohypoaldosteronism","in","eight","families",":","different","forms","of","inheritance","are","evidence","for","various","genetic","defects","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3612","tokens":["In","all","cells","tested",",","IL-10","activated","Stat1","and","Stat3","and","induced","the","formation","of","three","distinct","DNA","binding","complexes","that","contained","different","combinations","of","these","two","transcription","factors","."],"ner_tags":[0,0,0,0,0,9,0,9,0,9,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,10,0]}
{"id":"14179","tokens":["Constitutive","expression","in","vivo","of","Fos",",","and","to","a","lesser","extent","Fra-1",",","eliminates","the","requirement","for","phorbol","12-myristate","13-acetate","(","PMA",")","stimulation",",","leaving","NF-AT","-directed","transcription","responsive","to","calcium","ionophore","alone","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0]}
{"id":"2897","tokens":["Signals","transduced","via","the","TCR","activate","the","transcription","factor","nuclear","factor-kappaB","(","NF-kappaB",")",",","which",",","in","turn",",","is","critical","to","the","transcriptional","induction","of","many","genes","important","for","the","proliferation","and","expression","of","a","differentiated","phenotype","."],"ner_tags":[0,0,0,0,9,0,0,9,10,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6029","tokens":["An","open","reading","frame","that","is","approximately","60","%","identical","to","the","E.","coli","rpoS","gene","was","identified","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0]}
{"id":"8616","tokens":["Sequence","analysis","of","the","p40","promoter","region","identified","two","potential","nuclear","factor","(","NF",")","-kappaB","binding","sites","conserved","between","mouse","and","human","."],"ner_tags":[0,0,0,0,1,2,2,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,0]}
{"id":"6935","tokens":["Pretreatment","of","cultured","human","ECs","with","the","PPARalpha","activators","fenofibrate","or","WY14643","inhibited","TNF-alpha-induced","VCAM-1","in","a","time-","and","concentration-dependent","manner",",","an","effect","not","seen","with","PPARgamma","activators","."],"ner_tags":[0,0,7,8,8,0,0,9,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"18141","tokens":["Complex","2","corresponds","to","binding","of","transcription","factor","(","upstream","stimulatory","factor",")","to","an","E-box","motif","in","the","5","'","portion","of","the","NIP","region","."],"ner_tags":[9,10,0,0,0,0,9,10,0,9,10,10,0,0,0,1,2,0,0,1,2,2,0,0,1,2,0]}
{"id":"13224","tokens":["Given","the","reported","long-range","cis-inactivating","effect","of","the","XIST","gene","in","early","embryonic","development","and","the","lack","of","requirement","of","X-chromosome-specific","elements","for","propagating","the","inactive","state",",","there","exists","the","possibility","of","cis","inactivation","of","autosomal","material","after","de","novo","translocation","to","an","inactive","X","chromosome","(","Xi",")","in","differentiated","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,1,0,0,7,8,0]}
{"id":"13815","tokens":["We","further","demonstrate","that","0.1-0.5","microM","DMDTC","inhibits","intracellular","IL-2","production","and","decreases","surface","expression","of","CD25","(","the","alpha","subunit","of","the","IL-2","receptor",")","in","T","cells","stimulated","with","phorbol","ester","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,9,10,0,0,9,10,0,0,7,8,0,0,0,0,0]}
{"id":"2126","tokens":["Electrophoretic","mobility","shift","assays","failed","to","show","an","alpha-tcp-induced","decrease","in","activation","of","this","transcription","factor","after","cytokine","stimulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0]}
{"id":"16621","tokens":["The","number","of","estrogen","receptor","(","ER",")","in","human","peripheral","leucocytes","in","13","men","with","gynecomastia","were","measured","by","radioligand","binding","method.","The","results","were","compared","with","those","of","13","sex-and","age-matched","healthy","subjects","."],"ner_tags":[0,0,0,9,10,0,9,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3833","tokens":["The","biochemical","modifications","responsible","for","the","defect","in","transduction","and","execution","of","the","proliferative","signal","are","analyzed","as","a","function","of","age","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4150","tokens":["Our","results","emphasize","the","multiple","levels","at","which","NFAT-dependent","transactivation","is","regulated",",","and","predict","significant","differences","in","the","architecture","of","cooperative","transcription","complexes","containing","different","NFAT-family","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,0]}
{"id":"15219","tokens":["A","novel","Ets-related","transcription","factor",",","Elf-1",",","binds","to","human","immunodeficiency","virus","type","2","regulatory","elements","that","are","required","for","inducible","trans","activation","in","T","cells","."],"ner_tags":[0,0,9,10,10,0,9,0,0,0,1,2,2,2,2,2,2,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"14081","tokens":["Finally",",","the","ManLAM-mediated","activation","of","HIV-1","LTR","transcription","was","found","to","be","independent","of","the","autocrine","or","paracrine","action","of","endogenous","TNF-alpha","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"2463","tokens":["These","findings","highlight","the","role","of","thrombin","as","a","potential","regulator","of","T","lymphocyte","activation","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,7,8,0,0]}
{"id":"1532","tokens":["SCL","mRNA","levels","assessed","by","Northern","blot","in","day","7","cells","did","not","increase","significantly","in","response","to","Steel","factor","stimulation",",","suggesting","that","posttranscriptional","mechanisms","may","also","be","important","in","the","increase","in","SCL","protein","observed","in","response","to","Steel","."],"ner_tags":[3,4,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,9,0]}
{"id":"10745","tokens":["Molecular","cloning","and","characterization","of","a","cDNA",",","CHEMR1",",","encoding","a","chemokine","receptor","with","a","homology","to","the","human","C-C","chemokine","receptor",",","CCR-4","."],"ner_tags":[0,0,0,0,0,0,1,0,1,0,0,0,9,10,0,0,0,0,0,9,10,10,10,0,9,0]}
{"id":"14707","tokens":["Within","this","region",",","we","define","a","minimal","promoter","(","-62","to","+54",")","that","displays","erythroid-specific","activity","and","contains","two","DNA","binding","sites","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"16249","tokens":["This","factor","consists","of","two","DNA-binding","subunits","of","relative","molecular","mass","50",",","000","(","50K",")","associated","with","two","65K","subunits","."],"ner_tags":[0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"6116","tokens":["The","viral","proteins","are","believed","to","prolong","acute","and","persistent","adenovirus","infections","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"11955","tokens":["The","human","C\/EBP-epsilon","protein","exhibited","strong","and","specific","binding","to","double-stranded","DNA","containing","consensus","C\/EBP","sites","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,1,2,2,2,2,2,0]}
{"id":"7040","tokens":["Furthermore",",","PD98059","completely","blocked","the","TPA-induced","differentiation","of","ML-1","cells",",","as","assessed","by","a","number","of","features","associated","with","mononuclear","differentiation","including","changes","in","morphology",",","nonspecific","esterase","activity",",","phagocytic","ability",",","NADPH","oxidase","activity",",","mitochondrial","respiration",",","and","c-jun","mRNA","inducibility","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,0,0,0,0,0,0,3,4,0,0]}
{"id":"10904","tokens":["In","combination",",","EBF","and","E47","induce","efficient","expression","of","the","endogenous","immunoglobulin","surrogate","light","chain","genes",",","lambda5","and","VpreB",",","whereas","other","pre-B","cell-specific","genes","remain","silent","."],"ner_tags":[0,0,0,9,0,9,0,0,0,0,0,1,2,2,2,2,2,0,1,0,1,0,0,0,1,2,2,0,0,0]}
{"id":"17735","tokens":["PROBLEM",":","The","clinical","significance","of","the","differential","expression","of","estrogen","receptor","(","ER",")","in","human","monocytes","was","evaluated","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,7,8,0,0,0]}
{"id":"103","tokens":["It","also","was","observed","that","suppression","of","cytokine","gene","expression","by","these","agents","was","independent","of","the","inhibition","of","proliferation","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14815","tokens":["The","stimulation","of","interleukin-1","alpha","production","by","okadaic","acid","was","more","modest","than","that","of","interleukin-1","beta","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"12850","tokens":["BCL-6","mutations","in","normal","germinal","center","B","cells",":","evidence","of","somatic","hypermutation","acting","outside","Ig","loci","."],"ner_tags":[9,0,0,7,8,8,8,8,0,0,0,0,0,0,0,1,2,0]}
{"id":"1898","tokens":["Our","results","suggest","that","the","target","of","PGE2","action","is","a","component","in","the","signal","transduction","pathway","leading","to","the","activation","of","protein","kinase","C","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"13252","tokens":["Hence","in","the","absence","of","p56",",","T","cell","receptor","triggered","activation","does","not","occur","."],"ner_tags":[0,0,0,0,0,9,0,9,10,10,0,0,0,0,0,0]}
{"id":"1433","tokens":["Stimulation","of","plus","clones","liberated","the","classical","p50-p65","complex","from","cytoplasmic","pools",",","whereas","minus","clones","produced","an","apparently","novel",",","faster-migrating","complex",",","as","judged","by","electrophoretic","mobility","shift","assays","."],"ner_tags":[0,0,5,6,0,0,0,9,10,0,0,0,0,0,5,6,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0]}
{"id":"5240","tokens":["Here","we","show","that","elevated","cAMP","levels","in","T","cells","correlate","with","the","expression","of","the","potent","transcriptional","repressor","ICER","(","inducible","cAMP","early","repressor",")","previously","described","in","the","hypothalamic-pituitary-gonadal","axis","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,9,10,10,9,0,9,10,10,10,0,0,0,0,0,0,0,0]}
{"id":"16390","tokens":["Gender","difference","in","the","number","of","GR","was","not","significant",",","although","women","showed","slightly","fewer","GR","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"12961","tokens":["Nor","was","fragmentation","observed","after","treatment","with","RU38486",",","indicating","that","repression","of","AP-1","activity","is","not","involved","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0]}
{"id":"5989","tokens":["In","the","current","study",",","we","show","9-cis","retinoic","acid","(","RA",")",",","a","ligand","for","the","nuclear","hormone","receptor","retinoid","X","receptor","(","RXR",")","and","retinoic","acid","receptor","(","RAR",")",",","markedly","induces","the","expression","of","MCP-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0,9,0,0,9,10,10,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"9139","tokens":["The","importance","of","BCL2","and","Stat3","on","IL-6","-induced","macrophage-differentiation","and","apoptosis","was","studied","with","1A9-M","cells","expressing","human","BCL2","or","a","dominant-negative","form","of","Stat3",",","respectively","."],"ner_tags":[0,0,0,9,0,9,0,9,0,0,0,0,0,0,0,5,6,0,9,10,0,0,0,0,0,9,0,0,0]}
{"id":"13812","tokens":["This","inhibition","is","not","accompanied","by","a","loss","in","viability",",","and","DMDTC-treated","T","cells","retain","other","active","signaling","pathways","throughout","the","exposure","duration","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"14042","tokens":["In","vitro","stimulation","did","not","affect","ER","mRNA","expression","."],"ner_tags":[0,0,0,0,0,0,3,4,0,0]}
{"id":"8200","tokens":["This","suggests","that","p38","MAP","kinase","may","play","an","important","role","in","regulating","STAT","serine","phosphorylation","in","response","to","the","combination","of","IL-12","and","IL-2","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"10680","tokens":["In","the","majority","of","cases",",","RARalpha","translocates","and","fuses","with","the","promyelocytic","leukemia","(","PML",")","gene","located","on","chromosome","15","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,1,2,2,2,2,2,0,0,1,2,0]}
{"id":"9197","tokens":["The","actual","binding","of","these","peptides","was","analysed","in","a","stabilization","assay","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3853","tokens":["MNDA","(","myeloid","cell","nuclear","differentiation","antigen",")","is","an","interferon","alpha","regulated","nuclear","protein","expressed","only","in","cells","of","the","human","myelomonocytic","lineage","."],"ner_tags":[9,0,9,10,10,10,10,0,0,0,9,10,10,10,10,0,0,0,0,0,0,7,8,8,0]}
{"id":"1584","tokens":["In","the","absence","of","estrogen","about","half","of","the","cells","enter","a","quiescent","non-proliferative","state","whereas","the","others","die","by","apoptosis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3697","tokens":["Moreover",",","alteration","of","any","one","of","these","features","(","e.g.",",","cis-element",",","trans-factor",",","or","cell-specific","background",")","switched","c-Jun","to","a","transcriptional","activator","of","the","rPRL","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,9,0,0,9,10,0,0,1,2,0]}
{"id":"7432","tokens":["These","data","show","that","human","PCD\/DCoH","is","not","only","present","in","cells","where","tetrahydrobiopterin","is","synthesized","or","HNF1","is","present","but","is","a","widely","distributed","protein","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"4456","tokens":["Recently","it","has","become","clear","that","these","cytokines","activate","a","number","of","important","intracellular","signaling","molecules",",","including","the","Janus","kinases","JAK1","and","JAK3","and","members","of","the","transcription","factor","family","of","signal","transducers","and","activators","of","transcription","(","STATs",")","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,10,0,0,0,9,10,9,0,9,0,0,0,0,9,10,10,0,9,10,0,9,10,10,0,9,0,0]}
{"id":"461","tokens":["We","have","examined","the","function","of","these","elements","in","Burkitt","'s","lymphoma","cells","(","Ramos","and","Daudi",")","as","well","as","a","T","lymphocytic","cell","line","(","Jurkat",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,5,6,6,6,0,5,0,5,0,0,0,0,0,5,6,6,6,0,5,0,0]}
{"id":"8280","tokens":["Consistent","with","previous","data","from","human","and","mouse","fibroblasts","and","T-lymphocytes",",","E2F4","and","DP1","form","the","predominant","E2F","heterodimers","both","in","G0","and","G1","phases","of","the","human","B-lymphocyte","cell","cycle",",","whereas","E2F1","and","-3","are","first","detected","in","late","G1",",","and","their","expression","levels","increase","towards","S","phase","."],"ner_tags":[0,0,0,0,0,7,8,8,8,0,7,0,9,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17886","tokens":["The","mechanism","of","generation","of","p50","is","not","known","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0]}
{"id":"7990","tokens":["In","this","study",",","we","characterized","C.","pneumoniae-mediated","activation","of","endothelial","cells","and","demonstrated","an","enhanced","expression","of","endothelial","adhesion","molecules","followed","by","subsequent","rolling",",","adhesion",",","and","transmigration","of","leukocytes","(","monocytes",",","granulocytes",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,7,0,7,0,7,0,0]}
{"id":"15516","tokens":["Estrogen","binding","sites","in","peripheral","blood","monocytes","and","effects","of","danazol","on","their","sites","in","vitro","."],"ner_tags":[0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"13175","tokens":["The","addition","of","oxygen","radical","scavenger","enzymes","(","catalase",",","superoxide","dismutase",")","and","antioxidant","(","probucol",")","inhibited","these","events","."],"ner_tags":[0,0,0,9,10,10,10,0,9,0,9,10,0,0,0,0,0,0,0,0,0,0]}
{"id":"10987","tokens":["As","the","expression","level","of","the","RP1","gene","in","activated","T","cells","and","a","spectrum","of","tumor-derived","cell","lines","correlates","with","the","proliferative","status","of","the","cells",",","members","of","the","EB1-like","gene","family","may","not","only","be","involved","in","the","tumorigenesis","of","colorectal","cancers","but","may","also","play","a","role","in","the","proliferative","control","of","normal","cells","."],"ner_tags":[0,0,0,0,0,0,1,2,0,7,8,8,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"2150","tokens":["Five","cellular","proteins","(","p52",",","p57",",","p70",",","p72",",","and","p100",")","cross-link","the","EMCV","IRES","or","fragments","of","the","IRES","."],"ner_tags":[0,9,10,0,9,0,9,0,9,0,9,0,0,9,0,0,0,0,1,0,0,0,0,1,0]}
{"id":"4199","tokens":["We","found","that","the","adenylate","cyclase","activator",",","forskolin",",","inhibits","anti-CD3","-induced","shift","in","Lck","electrophoretic","mobility",",","suggesting","an","intervention","at","the","TCR","-coupled","phosphoinositide","turnover","that","precedes","the","activation","of","PKC","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0]}
{"id":"9436","tokens":["Consistent","with","this","result",",","mutation","of","the","EBNA2","response","element","(","a","CBF1\/RBP-Jkappa","binding","site",")","in","Cp","also","prevented","significant","repression","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0,0,1,0,0,0,0,0]}
{"id":"15104","tokens":["The","effects","of","many","C-11-substituted","1","alpha",",","25-","(","OH",")","2D3","analogs","on","HL-60","cell","differentiation","exceeded","their","activity","on","calcium","metabolism","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,0,0,0,0,0,0,0,0,0]}
{"id":"3726","tokens":["These","properties","suggest","that","TAFII105","is","a","cell","type-specific","subunit","of","TFIID","that","may","be","responsible","for","mediating","transcription","by","a","subset","of","activators","in","B","cells","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"3149","tokens":["These","involve","activation","of","the","sodium\/proton-exchanger","of","the","cell","membrane","at","very","low",",","physiological","concentrations","of","aldosterone","with","an","acute","onset","within","1-2","minutes","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13248","tokens":["Although","IFN-gamma","alone","did","not","induce","CD23","mRNA","transcription",",","Northern","blot","analysis","revealed","a","transient","up-regulation","of","the","IL-4-induced","CD23","mRNA","by","IFN-gamma","within","2","h","of","IFN-gamma","treatment","in","these","tonsillar","cells","."],"ner_tags":[0,9,0,0,0,0,3,4,0,0,0,0,0,0,0,0,0,0,0,3,4,4,0,9,0,0,0,0,9,0,0,0,7,8,0]}
{"id":"6073","tokens":["A","significant","2-4","fold","increase","of","c-fos","expression","was","observed","within","30","min","of","stimulation","with","IL-10","(","p","<","0.01",")","."],"ner_tags":[0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"8721","tokens":["In","contrast",",","both","in","Th1","and","Th2","clones","NFAT-containing","complexes","were","strongly","inducible","at","the","P1","site",",","consisting","of","NFAT2","and","a","P0","-compatible","NFAT","activity",",","without","apparent","differences","between","Th1","and","Th2","clones","."],"ner_tags":[0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,1,2,0,0,0,9,0,0,1,0,9,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"5051","tokens":["Expression","of","ATF-2","in","S.","cerevisiae","did","not","activate","TRE-1","in","the","presence","of","Tax","."],"ner_tags":[0,0,9,0,0,0,0,0,0,1,0,0,0,0,9,0]}
{"id":"14915","tokens":["The","affinity","of","the","BAT","box","binding","proteins","for","the","BAT","box","was","approximately","25-fold","less","than","for","the","octamer","sequence","and","the","BAT","box","binding","proteins","dissociated","from","the","BAT","box","10-fold","more","rapidly","than","from","the","octamer","sequence","."],"ner_tags":[0,0,0,0,9,10,10,10,0,0,1,2,0,0,0,0,0,0,0,1,2,0,0,9,10,10,10,0,0,0,1,2,0,0,0,0,0,0,1,2,0]}
{"id":"4467","tokens":["This","effect","of","the","CMV","immediate","early","1","gene","product","was","dependent","upon","the","presence","of","specific","transcription","factor","binding","sites","in","the","IL-6","promoter","."],"ner_tags":[0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,0,0,1,2,2,2,0,0,1,2,0]}
{"id":"11298","tokens":["Immunochemical","and","immunofluorescent","staining","of","thymus","sections","using","specific","Abs","allowed","visualization","of","nuclear","NF-kappa","B","proteins","in","both","thymocytes","and","nonthymocyte","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,10,10,0,0,7,0,7,8,0]}
{"id":"2375","tokens":["In","fertile","women","remarkable","changes","in","androgen","binding","sites","were","seen","in","the","course","of","the","menstrual","cycle",",","with","a","significant","increase","in","the","immediate","preovulatory","period","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8226","tokens":["Similarly",",","IL-2","neither","activates","JNK","nor","increases","AP-1","binding","activity","to","a","consensus","o-tetradecanoylphorbol","13-acetate","(","TPA",")","response","element","."],"ner_tags":[0,0,9,0,0,9,0,0,9,0,0,0,0,0,1,2,2,2,2,2,2,0]}
{"id":"16095","tokens":["Transcription","factor","requirements","for","U2","snRNA","-encoding","gene","activation","in","B","lymphoid","cells","."],"ner_tags":[9,10,0,0,3,4,0,0,0,0,7,8,8,0]}
{"id":"6074","tokens":["After","2","hrs","c-fos","expression","declined","to","basal","levels","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0]}
{"id":"11705","tokens":["Furthermore",",","Pax-5a","and","Pax-5b","proteins","were","detected","using","Western","blot","analysis","."],"ner_tags":[0,0,9,0,9,10,0,0,0,0,0,0,0]}
{"id":"3561","tokens":["Earlier","studies","on","the","IL-2","gene","expression","showed","that","overexpression","of","calcineurin","(","CN",")",",","a","Ca2+\/calmodulin-dependent","protein","phosphatase",",","can","stimulate","transcription","from","the","IL-2","promoter","through","the","NF-AT-binding","site","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,9,0,9,0,0,0,9,10,10,0,0,0,0,0,0,1,2,0,0,1,2,0]}
{"id":"13566","tokens":["The","ability","of","small","molecules","to","target","predetermined","DNA","sequences","located","within","RNA","polymerase","II","promoters","suggests","a","general","approach","for","regulation","of","gene","expression",",","as","well","as","a","mechanism","for","the","inhibition","of","viral","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,1,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14711","tokens":["Mutations","and","deletions","of","both","sites","indicate","that","only","the","association","of","CCACC\/Sp1","and","GATA","binding","sites","can","drive","efficient","and","tissue-specific","expression","of","this","R-PK","minimal","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,1,2,2,0,0,0,0,0,0,0,0,9,1,2,0]}
{"id":"4396","tokens":["The","PML","gene","product","has","been","localized","to","subnuclear","dot-like","structures","variously","termed","PODs",",","ND10s",",","Kr","bodies",",","or","PML","nuclear","bodies","(","PML","NBs",")","."],"ner_tags":[0,9,10,10,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10777","tokens":["An","enhancer-blocking","element","(","BEAD-1",",","for","blocking","element","alpha\/delta","1",")","was","localized","to","a","2.0-kb","region","3","'","of","TCR","delta","gene","segments","and","5","'","of","TCR","alpha","joining","gene","segments","within","this","locus","."],"ner_tags":[0,1,2,0,1,0,0,0,1,2,2,0,0,0,0,0,1,2,0,0,0,1,2,2,2,0,0,0,0,1,2,2,2,2,0,0,0,0]}
{"id":"12285","tokens":["Using","immunological","cross-linking","to","mimic","receptor","engagement","by","natural","ligands",",","we","now","show","that","CD15","(","Lewis","X",")",",","a","monocyte","counter-receptor","for","endothelial","selectins","may","participate","in","this","response","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,0,0,0,0,0]}
{"id":"919","tokens":["Major","depressive","disorder","(","MDD",")","in","adolescents","demonstrates","resistance","to","tricyclic","antidepressants","and","absence","of","hypercortisolemia","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5001","tokens":["Thus",",","A-myb","expression",",","unlike","that","of","c-myb","and","B-myb",",","is","restricted","to","a","subset","of","B-cell","neoplasias","(","in","particular","BL","and","slg+B-ALL",")","representative","of","a","specific","stage","of","B-cell","differentiation","."],"ner_tags":[0,0,1,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15515","tokens":["These","findings","provide","direct","in","vivo","evidence","to","strongly","suggest","that","the","modulation","of","X1","and","X2","interactions","is","an","important","constituent","of","the","interferon","gamma","induction","pathway","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,9,10,0,0,0]}
{"id":"8429","tokens":["Moreover",",","NF-ATp","-\/-","mice","older","than","6","weeks","show","an","2-5","fold","increase","in","number","of","lymphocytes","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"17877","tokens":["Although","evidence","indicates","that","dehydroepiandrosterone","(","DHEA",")","exerts","direct","physiological","effects",",","its","mechanism","of","action","remains","unknown","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3329","tokens":["Thus","these","results","suggest","a","direct","contribution","of","EBV","to","chronic","rheumatoid","arthritis","pathogenesis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8820","tokens":["Down-regulation","of","NF-kappaB","activation","is","known","to","inhibit","HIV","replication","from","the","latently","infected","cells","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"11248","tokens":["These","results","suggest","that","underlying","aberrancies","in","the","induction","of","c-fos\/c-jun","as","well","as","their","nuclear","regulatory","proteins","may","contribute","to","the","age-related","impairments","of","AP-1","activation","in","human","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,0,0,7,8,8,0]}
{"id":"4093","tokens":["In","A20","B","cells",",","the","TNF-alpha","gene","is","not","regulated","by","NFATp","bound","to","the","kappa","3","element","."],"ner_tags":[0,5,6,6,0,0,1,2,0,0,0,0,9,0,0,0,1,2,2,0]}
{"id":"13584","tokens":["Upregulation","of","interleukin","6","and","granulocyte","colony-stimulating","factor","receptors","by","transcription","factor","CCAAT","enhancer","binding","protein","alpha","(","C\/EBP","alpha",")","is","critical","for","granulopoiesis","."],"ner_tags":[0,0,9,10,0,9,10,10,10,0,9,10,9,10,10,10,10,0,9,10,0,0,0,0,0,0]}
{"id":"10136","tokens":["During","humoral","immune","responses",",","B-lymphocyte","activation","is","followed","by","differentiation","along","either","the","plasma","cell","pathway","or","the","memory","B-cell","pathway","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9636","tokens":["After","DMSO","treatment",",","HL-60","cells","eventually","died","via","apoptosis",",","whereas","the","viability","of","PDBu-treated","cells","was","not","affected","during","the","same","interval","."],"ner_tags":[0,0,0,0,5,6,0,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0]}
{"id":"15484","tokens":["Furthermore","there","was","a","clear-cut","synergy","between","the","PKC","stimulator","and","the","cAMP","elevating","agents","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0]}
{"id":"15384","tokens":["This","full","length","promoter","construct","can","be","induced","by","phorbol","13-myristate","acetate","(","PMA",")","in","each","of","these","cell","types","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4447","tokens":["The","proliferative","responses","of","purified","CD4+","or","CD8+","T","cells","are","suppressed","more","strongly","by","TPCK","when","anti-CD28","rather","than","the","phorbol","ester","PMA","is","used","as","the","mitogenic","coactivator","."],"ner_tags":[0,0,0,0,7,8,8,8,8,8,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"1360","tokens":["Recent","evidence","suggests","a","role","for","oxidant","stress","in","the","signalling","pathway","of","various","cell","types","by","virtue","of","its","ability","to","induce","DNA","binding","of","various","transcription","factors",",","including","nuclear","factor","kappa","B","and","AP-1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,9,10,10,10,0,9,0]}
{"id":"4621","tokens":["Receptors","for","interleukin","(","IL",")","-10","and","IL-6-type","cytokines","use","similar","signaling","mechanisms","for","inducing","transcription","through","IL-6","response","elements","."],"ner_tags":[0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"9202","tokens":["The","stability","of","already","formed","complexed","was","somewhat","different","in","the","HLA-A3","and","HLA-Cw*0702","system",":","both","were","more","stable","at","26","degrees","C","than","at","37","degrees","C","but","while","the","beta","2-m","and","FCS","did","not","influence","the","stability","of","the","HLA-A3\/peptide","complex",",","they","seemed","to","cause","opposite","effects","in","the","HLA-Cw*0702","system","(","beta","2-m","stabilized","and","FCS","destabilized","the","complex",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"13232","tokens":["Interleukin-4","and","-13","induce","upregulation","of","the","murine","macrophage","12\/15-lipoxygenase","activity",":","evidence","for","the","involvement","of","transcription","factor","STAT6","."],"ner_tags":[9,10,10,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,10,9,0]}
{"id":"5484","tokens":["In","combination","with","TNF-alpha",",","IL-10","stimulated","activating","protein-1","(","AP-1",")","and","nuclear","factor","(","NF",")","-kappa","B","binding","activities","and","cooperated","to","increase","HIV-1","steady-state","mRNA","levels","and","enhance","long","terminal","repeat","-directed","transcription","through","activation","of","the","NF-kappa","B","binding","sites",",","suggesting","the","IL-10","effect","occurs","at","least","in","part","at","the","transcriptional","level","."],"ner_tags":[0,0,0,9,0,9,0,9,10,0,9,0,0,9,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,1,2,2,2,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5821","tokens":["This","NF-kappaB-like","element","was","able","to","form","a","complex","with","NF-kappaB","family","proteins","in","vitro","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,9,10,10,0,0,0]}
{"id":"11994","tokens":["S-allyl","cysteine","inhibits","activation","of","nuclear","factor","kappa","B","in","human","T","cells","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,7,8,8,0]}
{"id":"2213","tokens":["To","investigate","the","effects","of","human","immunodeficiency","virus","type","1","(","HIV-1",")","Tat","on","interleukin-2","(","IL-2",")","expression",",","we","used","IL-2","promoter-chloramphenicol","acetyltransferase","constructs","and","IL-2-secreting","Jurkat","T","cells","as","a","model","system","."],"ner_tags":[0,0,0,0,0,9,10,10,10,10,10,10,10,10,0,9,0,9,0,0,0,0,0,1,2,2,2,0,5,6,6,6,0,0,0,0,0]}
{"id":"8344","tokens":["Detection","of","NF-ATc.alpha","mRNA","is","strictly","dependent","on","cell","activation","signals","in","both","T","and","mast","cell","lines","."],"ner_tags":[0,0,3,4,0,0,0,0,0,0,0,0,0,5,6,6,6,6,0]}
{"id":"15416","tokens":["Taken","together",",","these","findings","indicate","that","the","induction","of","c-jun","transcription","by","okadaic","acid","is","controlled","primarily","by","a","transcriptional","mechanism","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13119","tokens":["NF-kappaB","only","partially","mediates","Epstein-Barr","virus","latent","membrane","protein","1","activation","of","B","cells","."],"ner_tags":[9,0,0,0,9,10,10,10,10,10,0,0,0,0,0]}
{"id":"15713","tokens":["Cortisol","resistance","in","acquired","immunodeficiency","syndrome","."],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"12619","tokens":["This","observation","is","likely","to","relate","to","the","findings","that","TAL1","and","LMO","are","highly","synergistic","in","T-cell","tumorigenesis","in","double-transgenic","mice","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0]}
{"id":"2883","tokens":["Induction","of","tyrosine","phosphorylation","and","T-cell","activation","by","vanadate","peroxide",",","an","inhibitor","of","protein","tyrosine","phosphatases","."],"ner_tags":[0,0,0,0,0,7,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"13474","tokens":["Truncation","of","the","beta","globin","promoter","led","to","a","2-3","fold","increase","in","promoter","activity","."],"ner_tags":[0,0,0,1,2,2,0,0,0,0,0,0,0,0,0,0]}
{"id":"6823","tokens":["Although","spontaneous","tumorigenesis","was","not","observed",",","IL-2","production","with","Concanavalin","A","stimulation","was","significantly","increased","in","transgenic","mice","overexpressing","ICSAT","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"13646","tokens":["To","determine","whether","activation","of","these","cytokine","signaling","pathways","by","v-Abl","is","important","in","the","cellular","events","induced","by","the","Abelson","murine","leukemia","virus",",","the","effects","of","IL-4","and","IL-7","on","pre-B","cells","transformed","with","a","temperature-sensitive","v-Abl","mutant","were","examined","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,7,8,0,0,0,9,10,10,0,0,0]}
{"id":"4446","tokens":["In","addition",",","NAC","blocks","the","suppression","of","T","cell","mitogenesis","and","cytokine","production","by","protease","inhibitors","such","as","N-tosylphenylalanine","chloromethyl","ketone","(","TPCK",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7655","tokens":["These","results","suggest","that","a","decline","in","proteasome","activity","results","in","a","failure","to","fully","degrade","IkappaBalpha","in","the","elderly","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"2062","tokens":["On","the","other","hand",",","stimulation","of","T","cells","by","mitogens","or","antibodies","to","the","T-cell","receptor","(","TCR",")","-","CD3","complex","resulted","in","the","down-regulation","of","transcriptional","factors","NF-kappa","B","and","AP-1","in","cells","expressing","the","nef","gene","compared","with","cells","not","expressing","the","nef","gene","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3575","tokens":["Identification","of","Bcd",",","a","novel","proto-oncogene","expressed","in","B-cells","."],"ner_tags":[0,0,1,0,0,0,1,0,0,7,0]}
{"id":"3628","tokens":["Zinc","is","an","important","trace","element","for","immune","function","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0]}
{"id":"3908","tokens":["These","results","suggest","that","IFN-alpha5","and","IFN-beta","are","produced","at","low","levels","in","normal","tissues","and","play","an","important","role","in","the","regulation","of","cell","function","and","in","the","maintenance","of","homeostasis","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"5069","tokens":["Inhibition","of","alpha","interferon","but","not","gamma","interferon","signal","transduction","by","phorbol","esters","is","mediated","by","a","tyrosine","phosphatase","."],"ner_tags":[0,0,9,10,0,0,9,10,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"9932","tokens":["These","RelB+","APC","were","potent","stimulators","of","the","MLR","."],"ner_tags":[0,7,8,0,0,0,0,0,9,0]}
{"id":"14071","tokens":["Thus",",","the","difference","of","the","possible","T\/NK-cell","phenotype","in","the","BM","may","strongly","influence","clinical","and","molecular","remission","."],"ner_tags":[0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17519","tokens":["The","effect","of","heat","shock","on","the","expression","of","the","nuclear","protooncogenes","c-fos",",","c-jun",",","and","c-myc","was","studied","in","human","lymphoid","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,1,2,1,0,1,0,0,1,0,0,0,7,8,8,0]}
{"id":"2635","tokens":["To","examine","whether","GATA-1","expression","involves","additional","regulatory","factors","or","is","maintained","entirely","by","an","autoregulatory","loop",",","we","have","used","a","transient","heterokaryon","system","to","test","the","ability","of","erythroid","factors","to","activate","the","GATA-1","gene","in","nonerythroid","nuclei","."],"ner_tags":[0,0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,1,2,0,0,0,0]}
{"id":"10798","tokens":["Transcription","factors","in","immune-mediated","disease","."],"ner_tags":[9,10,0,0,0,0]}
{"id":"15635","tokens":["Partial","cortisol","receptor","resistance","might","be","less","rare","than","previously","thought","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1103","tokens":["Insertion","of","this","chimeric","promoter","(","ISG15","LTR",")","upstream","of","the","human","IFNA2","gene","directed","high","levels","of","IFN","synthesis","in","Tat-expressing","cells",",","while","this","promoter","was","not","responsive","to","tumor","necrosis","factor","alpha","-mediated","activation","."],"ner_tags":[0,0,0,1,2,0,1,2,0,0,0,0,1,2,2,0,0,0,0,9,0,0,5,6,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0]}
{"id":"18050","tokens":["Here","we","report","that","cross-linking","of","Fc","gamma","RI","or","Fc","gamma","RII","by","adherent","human","IgG","or","by","specific","anti-Fc","gamma","R","mAb","activates","HIV-1","gene","expression","in","the","human","monocytic","cell","line","BF24","and","increased","HIV","RNA","expression","in","monocytes","from","HIV","infected","patients","as","assayed","by","reverse","transcription-PCR","."],"ner_tags":[0,0,0,0,0,0,9,10,10,0,9,10,10,0,9,10,10,0,0,0,9,10,10,10,0,0,0,0,0,0,5,6,6,6,5,0,0,3,4,0,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"8595","tokens":["Early","B-cell","factor","(","EBF",")","is","a","transcription","factor","suggested","as","essential","for","early","B-lymphocyte","development","by","findings","in","mice","where","the","coding","gene","has","been","inactivated","by","homologous","disruption","."],"ner_tags":[9,10,10,0,9,0,0,0,9,10,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10387","tokens":["Little","is","known","about","the","role","of","CD40","in","fibroblasts","."],"ner_tags":[0,0,0,0,0,0,0,9,0,7,0]}
{"id":"14233","tokens":["An","enhancement","of","NK","activity","by","E2","was","also","seen","in","large","granular","lymphocytes","obtained","from","normal","subjects",",","and","it","was","again","suppressed","by","Tx","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15617","tokens":["Primary","(","partial",")","cortisol","receptor","resistance","was","previously","reported","in","a","total","of","7","patients","and","14","asymptomatic","family","members","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2318","tokens":["The","oxygen","radical","scavenger","N-acetyl-L-cysteine",",","but","not","an","inhibitor","of","nitric","oxide","synthase",",","inhibited","LIF","-induced","HIV","replication","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,9,0,0,0,0]}
{"id":"3468","tokens":["By","in","vitro","transcription","assays",",","DM","regulated","IL-2R","alpha","gene","expression","at","a","transcriptional","level","while","transcription","of","IL-2R","beta","gene","was","unaffected","by","DM","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0]}
{"id":"5422","tokens":["Mutagenesis","of","the","activator","protein-1","[","AP-1","]","site","at","-72","abolished","basal","promoter","activity","and","LPS\/zymosan","inducibility",",","while","mutagenesis","of","an","NF-kappaB-like","site","at","-20","to","-10","had","no","effect","."],"ner_tags":[0,0,0,1,2,2,2,2,2,0,1,0,1,2,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0]}
{"id":"5313","tokens":["Permanent","occupancy","of","the","human","immunodeficiency","virus","type","1","enhancer","by","NF-kappa","B","is","needed","for","persistent","viral","replication","in","monocytes","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,0,9,10,0,0,0,0,0,0,0,7,0]}
{"id":"5623","tokens":["In","electrophoretic","mobility","shift","assays","using","the","E1","oligonucleotide","as","probe",",","nuclear","extracts","from","unstimulated","T","and","B","cell","lines","formed","a","constitutive","complex","termed","complex","I",",","while","nuclear","extracts","from","stimulated","SCM-1-producer","T","cell","lines","formed","a","higher","mobility","complex","termed","complex","II","with","a","concomitant","decrease","in","complex","I","."],"ner_tags":[0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,9,10,0,9,10,0,0,0,0,0,0,5,6,6,6,0,0,9,10,10,0,9,10,0,0,0,0,0,9,10,0]}
{"id":"334","tokens":["The","present","studies","have","examined","the","effects","of","pokeweed","mitogen","(","PWM",")","on","the","induction","of","early","growth","response-1","gene","(","EGR-1",")","in","normal","human","B","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,1,2,2,2,0,1,0,0,7,8,8,8,0]}
{"id":"9721","tokens":["The","three-dimensional","positioning","of","immunoglobulin","(","Ig",")","genes","within","the","nucleus","of","human","cells","was","investigated","using","in","situ","hybridization","and","confocal","microscopy","."],"ner_tags":[0,0,0,0,1,2,2,2,2,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"12198","tokens":["Here",",","we","intend","to","demonstrate","the","requirement","of","GATA-1","and","NF-E2","transcription","factors","in","the","BA-induced","erythroid","differentiation","of","human","leukemic","K562","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,9,9,10,0,0,0,0,0,0,5,6,6,6,0]}
{"id":"8493","tokens":["This","is","manifested","by","the","ability","of","Delta","to","restore","induction","of","calcium","fluxes","and","mitogen-activated","protein","kinase","activation","and","by","the","ability","of","dominant","negative","Ras","and","FK506","to","block","the","induction","of","NF-AT","activity","mediated","by","Delta","."],"ner_tags":[0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,9,0,0,0,9,0]}
{"id":"5897","tokens":["Here","we","show","that","1alpha",",","25","(","OH",")","2-d5-previtamin","D3","(","HF",")",",","JN",",","KH1060",",","and","MC903","induce","expression","of","PKC","alpha","and","PKC","delta","and","translocation","of","both","isoforms","to","the","particulate","fraction",",","and","PKC","alpha","to","the","nuclear","fraction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0]}
{"id":"13993","tokens":["Gene","targeting","experiments","in","the","mouse","revealed","a","differential","dependency","of","fetal","and","adult","B-lymphopoiesis","on","this","transcription","factor","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"13217","tokens":["However",",","this","region","directed","extremely","low","reporter","mRNA","levels","relative","to","endogenous","IL-4","mRNA",",","suggesting","that","full","gene","activity","requires","additional","enhancer","elements","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"17803","tokens":["These","results","allowed","us","to","use","these","pathological","platelets","to","study","the","relationship","between","the","expression","of","Rap1","protein","and","the","regulation","of","Ca2+","transport","by","selecting","a","patient","with","severe","heart","failure","."],"ner_tags":[0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15885","tokens":["Interferon-gamma","potentiates","the","antiviral","activity","and","the","expression","of","interferon-stimulated","genes","induced","by","interferon-alpha","in","U937","cells","."],"ner_tags":[9,0,0,0,0,0,0,0,0,1,2,0,0,5,6,6,6,0]}
{"id":"12132","tokens":["Enhanced","differentiation","of","HL-60","leukemia","cells","to","macrophages","induced","by","ciprofibrate","."],"ner_tags":[0,0,0,5,6,6,0,7,0,0,0,0]}
{"id":"4341","tokens":["However",",","PHA\/PMA","but","not","oxidative","signals","induced","the","coordinate","activation","of","reporter","constructs","containing","the","AP-1-TRE",",","NF-AT",",","and","IL-2","promoter","regions","along","with","IL-2","mRNA","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,1,2,2,2,2,2,2,2,0,0,3,4,0,0]}
{"id":"13668","tokens":["Where","this","function","of","the","tumor","suppressor","proteins","is","impaired",",","the","capacity","for","differentiation","is","lost",",","which","leads","to","the","sustained","proliferation","that","is","characteristic","of","the","cancer","cell","."],"ner_tags":[0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"1249","tokens":["It","is","well","documented","that","treatment","of","serum-grown","HL60","cells","with","10","(","-7",")","M","all-trans","retinoic","acid","(","all-trans","RA",")","induces","neutrophil","differentiation",",","whereas","treatment","with","10","(","-7",")","M","1","alpha",",","25","dihydroxyvitamin","D3","(","D3",")","induces","differentiation","towards","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"6624","tokens":["These","results","indicate","that","ALG-4","is","necessary","and","sufficient","for","FasL","expression","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,0,0]}
{"id":"5176","tokens":["These","results","suggest","that","a","novel","mechanism","of","gene","regulation","by","``","differential","repression","''","is","used","by","multiple","members","of","repressor","proteins","with","different","repressive","effects","on","the","IFN-responsive","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,1,2,0]}
{"id":"9563","tokens":["Our","results","show","that","phosphorylation","of","STAT3alpha","on","serine","727","is","not","constitutive","in","quiescent","T","cells","but","can","be","induced","by","the","cytokine","IL-2","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,9,10,0]}
{"id":"16383","tokens":["Furthermore",",","treatment","of","nuclear","extracts","from","these","cells","that","had","restricted","expression","with","lipopolysaccharide","increased","viral","production","and","NF-kappa","B","activity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"6644","tokens":["Preactivation","of","T","cells","resulting","in","NF-kappa","B","nuclear","translocation","protected","cells","from","SN50-induced","apoptosis","."],"ner_tags":[0,0,7,8,0,0,9,10,0,0,0,0,0,0,0,0]}
{"id":"8423","tokens":["Sensitivity","(","ID50",")","of","the","lymphocytes","for","the","inhibitory","effect","of","dexamethasone","was","the","same","in","all","groups","."],"ner_tags":[0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"10114","tokens":["The","ability","of","BHRF1","to","protect","MCF-Fas","cells","from","apoptosis","induced","by","various","stimuli","was","identical","to","that","of","Bcl-2","and","Bcl-xL","."],"ner_tags":[0,0,0,9,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0]}
{"id":"9719","tokens":["Since","AP-1","is","part","of","the","NFAT","complex",",","we","conclude","that","the","IL-7","-signaling","pathway","is","involved","in","the","activation","of","the","fos","and","jun","proteins","of","which","AP-1","consists","."],"ner_tags":[0,9,0,0,0,0,9,10,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,9,0,0]}
{"id":"502","tokens":["Levels","of","the","octamer",",","NF-kappa","B","(","p50-p65","heterodimer",")",",","and","AP-1","transcriptional","factors","are","constitutively","elevated","in","freshly","isolated","Ipr","CD4-8-","T","cells",",","consistent","with","the","activated","phenotype","of","these","cells","."],"ner_tags":[0,0,0,0,0,9,10,0,9,10,0,0,0,9,10,10,0,0,0,0,0,0,5,6,6,6,0,0,0,0,0,0,0,0,0,0]}
{"id":"17997","tokens":["The","finding","related","to","social","support","also","replicates","results","from","an","independent","sample","of","breast","cancer","patients","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"9145","tokens":["Involvement","of","mitogen-activated","protein","kinase","pathways","in","interleukin-8","production","by","human","monocytes","and","polymorphonuclear","cells","stimulated","with","lipopolysaccharide","or","Mycoplasma","fermentans","membrane","lipoproteins","."],"ner_tags":[0,0,9,10,10,0,0,9,0,0,7,8,0,7,8,0,0,0,0,9,10,10,10,0]}
{"id":"17154","tokens":["These","constructs","were","transfected","into","either","HeLa","cells",",","Jurkat","cells","or","U937","cells","in","both","the","presence","and","absence","of","phorbol","esters","which","have","previously","been","demonstrated","to","activate","HIV","gene","expression","."],"ner_tags":[0,0,0,0,0,0,5,6,0,5,6,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8918","tokens":["We","have","analyzed","the","expression","of","IL-2Ralpha",",","c-myc",",","and","pim-1","genes","in","anti-CD3-activated","human","T","lymphocytes","."],"ner_tags":[0,0,0,0,0,0,9,0,1,0,0,1,2,0,7,8,8,8,0]}
{"id":"6786","tokens":["Additionally",",","overexpression","of","Vav",",","but","not","SLP-76",",","augments","CD28-induced","IL-2","promoter","activity","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,0,0,1,2,0,0]}
{"id":"17088","tokens":["The","virulence","defect","conferred","by","mutations","in","the","phoP","-phoQ","two-component","regulatory","system","is","not","completely","explained","by","alterations","in","resistance","to","cationic","proteins","and","involves","the","control","of","other","proteins","necessary","for","S.","typhimurium","survival","within","macrophages","."],"ner_tags":[0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0]}
{"id":"14330","tokens":["Surface","marker","analysis","showed","that","HMBA-induced","cells","expressed","reduced","levels","of","glycophorin","A",",","CD5",",","CD7","and","CD11b","."],"ner_tags":[0,0,0,0,0,5,6,0,0,0,0,9,10,0,9,0,9,0,9,0]}
{"id":"3083","tokens":["The","nature","of","the","nuclear","factors","involved","in","regulation","of","these","cytokine","genes","is","still","unknown","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0]}
{"id":"1956","tokens":["The","adult","male","progeny","(","3","mo","old",")","of","both","experimental","groups","showed","increased","basal","plasma","corticosterone","levels","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18175","tokens":["Costimulation","results","in","the","activation","of","a","signaling","pathway","that","leads","to","the","simultaneous","induction","of","the","two","transcription","factors",",","AP-1","and","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,10,0]}
{"id":"4383","tokens":["The","TH1-to-TH2","shift","may","be","responsible","for","the","stress-induced","susceptibility","of","the","organism","to","certain","infections","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2119","tokens":["Human","umbilical","vein","ECs","were","pretreated","with","alpha-tcp","before","stimulation","with","known","agonists","of","monocyte","adhesion",":","IL-1","(","10","ng\/ml",")",",","LPS","(","10","ng\/ml",")",",","thrombin","(","30","U\/ml",")",",","or","PMA","(","10","nM",")","."],"ner_tags":[0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"591","tokens":["Expression","studies","on","TCF-1","protein","have","been","hampered","by","the","difficulty","to","raise","antibodies","due","to","extreme","evolutionary","conservation","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"10768","tokens":["Stimulation","of","purified","T","lymphocytes","by","a","combination","of","monoclonal","antibodies","directed","at","CD2","and","CD28","adhesion","molecules","gives","rise","to","a","long","lasting","proliferation","in","the","absence","of","accessory","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,9,0,9,9,10,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"16932","tokens":["Concentration","of","receptors","of","hormonal","form","of","1",",","25","(","OH",")","2D3","was","found","to","be","minimal","in","lymphocytes","under","conditions","of","chronic","kidney","insufficiency",",","while","their","expression",",","after","the","dioxyvit","action",",","was","detected","only","in","patients","with","glomerulonephritis","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3738","tokens":["Loss","of","heterozygosity","in","PB","granulocytes","would","be","masked","by","the","presence","of","significant","numbers","of","normal","granulocytes","not","derived","from","the","malignant","clone","."],"ner_tags":[0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,5,6,0]}
{"id":"2134","tokens":["The","present","study","demonstrates","the","existence","of","kappa","B-specific","binding","factors","present","in","human","glial","astrocytes","that","differ","from","prototypical","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,10,0,0,7,8,8,0,0,0,0,9,10,0]}
{"id":"16135","tokens":["We","showed","here","by","mobility-shift","assay","that","T-cell","lines","transformed","with","the","virus","contained","high","levels","of","AP-1","activities","."],"ner_tags":[0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"17648","tokens":["Proteins","of","the","Ras","superfamily","are","likely","to","be","involved","in","a","variety","of","normal","phagocyte","functions","through","their","ability","to","modulate","the","assembly","of","actin","filaments",",","direct","vesicle","trafficking","and","fusion",",","and","so","forth","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"12631","tokens":["Peripheral","blood","mononuclear","cells","(","PBMCs",")","are","a","good","model","for","studies","of","GR","in","humans","."],"ner_tags":[7,8,8,8,0,7,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"7514","tokens":["These","results","suggest","that","haemoglobin","production","in","UT-7","cells","is","limited","by","a","deficiency","of","erythroid-specific","aminolaevulinic","acid","synthase","(","ALAS-E",")","activity","or","globin","synthesis","as","a","consequence","of","their","immaturity","as","a","multipotential","cell","line","."],"ner_tags":[0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,9,10,10,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0]}
{"id":"1892","tokens":["Addition","of","rIL-2","fully","restored","the","proliferative","response","and","partially","restored","the","production","of","IL-4","and","IL-5",",","but","not","that","of","other","cytokines","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,9,0]}
{"id":"18322","tokens":["These","findings","indicate","that","infection","of","human","mononuclear","phagocytes","with","L.","donovani","leads","to","impaired","gamma","interferon","-mediated","tyrosine","phosphorylation","and","selective","effects","on","the","Jak-","Stat1","pathway","."],"ner_tags":[0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,9,0,0]}
{"id":"7840","tokens":["The","rearrangements","lead","either","to","gene","truncation",",","and","to","expression","of","the","transcription","repressor","EVI1",",","as","seen","in","the","t","(","3",";","3",")","(","q21",";","q26",")","and","inv","(","3",")","(","q21q26",")",",","or","to","gene","fusion",",","as","seen","in","the","t","(","3",";","21",")","(","q26",";","q22",")","which","results","in","the","fusion","protein","AML1\/MDS1\/EVI1","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0,1,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0,0,0,0,0,0,9,0]}
{"id":"1620","tokens":["Mutagenesis","of","the","CKII","site","in","SM","made","no","difference","to","the","transactivation","in","this","transient","transfection","assay","."],"ner_tags":[0,0,0,9,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11818","tokens":["We","have","mapped","the","inhibitory","activity","to","less","than","60","residues",",","containing","motifs","that","are","conserved","in","all","NFAT","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,9,10,0]}
{"id":"6209","tokens":["To","gain","some","insight","into","the","maturation","of","M2-type","leukemic","cells",",","we","studied","the","molecular","mechanisms","underlying","monocytic","differentiation","induced","by","ATRA","and","VD","in","spontaneous","M2","blast","cells","as","well","as","in","Kasumi-1","cells","(","an","acute","myeloid","leukemia","M2-type","cell","line",")","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,0,0,0,0,5,6,0,0,5,6,6,6,6,6,0,0]}
{"id":"5351","tokens":["X","inactivation","analysis","was","performed","on","normal","and","hypopigmented","skin","samples","obtained","from","a","female","with","hypomelanosis","of","Ito","associated","with","a","balanced","whole","arm","X",";","17","translocation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,0]}
{"id":"5869","tokens":["However",",","a","physical","interaction","between","calcineurin","and","NFATp","has","not","been","demonstrated","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,0,0]}
{"id":"17450","tokens":["While","growing","either","with","or","without","albumin",",","the","several","clonal","lines","of","CEM","cells","displayed","growth","similar","to","serum-supplemented","cultures","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,5,6,0,5,0,0,0,0,0,0,0,0]}
{"id":"16178","tokens":["Characterization","of","a","cofactor","that","regulates","dimerization","of","a","mammalian","homeodomain","protein","."],"ner_tags":[0,0,0,9,0,0,0,0,0,9,10,10,0]}
{"id":"16885","tokens":["Although","negative","regulation","by","dimethyl","sulfoxide","takes","place","even","when","protein","synthesis","is","inhibited","by","cycloheximide",",","the","phorbol","myristate","acetate","effect","is","blocked","to","some","extent","only","by","cycloheximide","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1040","tokens":["We","cultured","M-TAT","cells","long","term","(",">","1","year",")","in","the","continuous","presence","of","erythropoietin","(","EPO",")",",","granulocyte-macrophage","colony-stimulating","factor","(","GM-CSF",")",",","or","stem","cell","factor","(","SCF",")","."],"ner_tags":[0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,9,10,10,0,9,0,0,0,9,10,10,0,9,0,0]}
{"id":"1233","tokens":["We","further","demonstrate","that","Tax","induction","of","nuclear","c-Rel","expression","is","activated","by","the","RelA","(","p65",")","subunit","of","NF-kappa","B",",","which","activates","transcription","of","the","c-rel","gene","through","an","intrinsic","kappa","B","enhancer","element","."],"ner_tags":[0,0,0,0,9,0,0,0,9,0,0,0,0,0,9,0,9,0,0,0,9,10,0,0,0,0,0,0,1,2,0,0,0,1,2,2,2,0]}
{"id":"7827","tokens":["Finally",",","CD40","ligation","induced","growth","inhibition","and","apoptosis","in","MM","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"7360","tokens":["It","is","known","that","sulfated","polysaccharides","can","mimic","the","action","of","common","T-cell","mitogens","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"169","tokens":["Induction","of","Sp1","phosphorylation","and","NF-kappa","B-independent","HIV","promoter","domain","activity","in","T","lymphocytes","stimulated","by","okadaic","acid","."],"ner_tags":[0,0,9,0,0,1,2,2,2,0,0,0,7,8,0,0,0,0,0]}
{"id":"14103","tokens":["DNA","from","peripheral","blood","leukocytes","of","six","patients","from","five","families","with","various","degrees","of","androgen","insensitivity","was","studied","."],"ner_tags":[0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11350","tokens":["A","molecular","basis","for","induction","of","antibodies","to","DNA","and","eukaryotic","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,9,10,10,0]}
{"id":"9196","tokens":["RESULTS",":","We","identified","peptides","derived","from","EWS\/FLI-1","fusion","protein","and","from","mutated","K-RAS","protein","(","encompassing","respectively","the","fusion","point","and","the","mutation","at","position","12",")","that","showed","binding","motif","for","HLA-Cw*0702","and","HLA-A3","respectively","."],"ner_tags":[0,0,0,0,0,0,0,9,10,10,0,0,9,10,10,0,0,0,0,9,10,0,0,0,0,9,10,0,0,0,9,10,0,9,0,9,0,0]}
{"id":"3946","tokens":["Both","forskolin","and","dibutyryl","cAMP",",","which","elevate","intracellular","cAMP","by","independent","mechanisms",",","inhibited","TNFalpha","and","tissue","factor","expression","at","the","level","of","transcription","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,10,0,0,0,0,0,0,0]}
{"id":"16120","tokens":["The","smaller","of","the","two","proteins","(","50","kDa",")","was","indistinguishable","from","the","classical","1",",","25","(","OH",")","2D3","receptor","and",",","similar","to","the","classical","1",",","25","(","OH",")","2D3","receptor",",","was","upregulated","in","a","dose-dependent","fashion","by","1",",","25","(","OH",")","2D3","."],"ner_tags":[0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"246","tokens":["We","propose","that","the","MNP","protein","(","s",")","binding","at","the","MNP","site","constitutes","a","novel","transcription","factor","(","s",")","expressed","in","hematopoietic","cells","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,1,2,0,0,0,9,10,0,0,0,0,0,7,8,0]}
{"id":"17500","tokens":["After","the","treatment","with","the","regimen","of","Kidney-tonifying","and","Qi-invigorating",",","the","GCR","of","the","aged","persons","and","rats","was","enhanced",",","and","in","this","way",",","the","function","of","the","aged","adrenal","cortex","was","improved","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2575","tokens":["Sequence","analyses","show","that","this","protein","has","significant","homology","with","the","human","cytomegalovirus","UL44","gene","coding","for","the","ICP36","family","of","early-late-class","phosphoprotein","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,9,10,0,9,10,0]}
{"id":"5278","tokens":["Antibodies","against","CRE-binding","(","CREB",")","protein","but","not","against","c-Fos","or","c-Jun","were","able","to","supershift","the","DNA-protein","complex",",","identifying","the","nature","of","the","transcription","factor","which","binds","to","ZII","as","a","member","of","the","CREB","family","of","proteins","."],"ner_tags":[0,0,9,10,10,10,10,0,0,0,9,0,9,0,0,0,0,0,9,10,0,0,0,0,0,0,9,10,0,0,0,1,0,0,0,0,0,9,10,10,10,0]}
{"id":"7476","tokens":["Treatment","with","E2","was","also","associated","with","a","time-dependent","decrease","in","the","mRNA","level","of","the","proapoptotic","Nip-2","protein",",","supporting","the","hypothesis","that","hormone","responsiveness","of","U937","cells","is","mediated","by","target","gene","transcription","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,5,6,0,0,0,0,0,0,0]}
{"id":"16289","tokens":["We","have","determined","that","the","developmental","control","of","immunoglobulin","kappa","3","'","enhancer","(","kappa","E3","'",")","activity","is","the","result","of","the","combined","influence","of","positive-","and","negative-acting","elements","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,2,2,0,1,2,2,0,0,0,0,0,0,0,0,0,0,1,2,2,2,0]}
{"id":"15018","tokens":["Furthermore",",","and","despite","a","lack","of","sequence","homology",",","the","promoters","of","IL-3","and","IL-2","share","an","organizational","pattern","of","regulatory","elements","that","is","likely","to","be","important","for","the","T-cell-specific","expression","of","these","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17971","tokens":["Although","the","expression","of","CD69","can","be","induced","in","vitro","on","cells","of","most","hematopoietic","lineages","with","a","wide","variety","of","stimuli",",","in","vivo","it","is","mainly","expressed","by","T-lymphocytes","located","in","the","inflammatory","infiltrates","of","several","human","diseases","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0,0,0,0,0]}
{"id":"14692","tokens":["Although","sequences","located","between","-559","and","-88","of","the","zeta","2","globin","gene","were","dispensable","for","its","expression","on","enhancerless","plasmids",",","they","were","required","for","the","HS-40","enhancer","-mediated","activity","of","the","zeta","2","globin","promoter","."],"ner_tags":[0,0,0,0,0,0,0,0,0,1,2,2,2,0,0,0,0,0,0,1,2,0,0,0,0,0,0,1,2,0,0,0,0,1,2,2,2,0]}
{"id":"7541","tokens":["This","mechanism","may","contribute","to","delayed","progression","of","the","HIV-1","infection","in","vivo","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"11585","tokens":["A","T","cell-specific","enhancer","in","the","interleukin-3","locus","is","activated","cooperatively","by","Oct","and","NFAT","elements","within","a","DNase","I-hypersensitive","site","."],"ner_tags":[0,1,2,2,0,0,1,2,0,0,0,0,1,2,2,2,0,0,1,2,2,0]}
{"id":"6504","tokens":["We","recently","reported","that","prolonged","exposure","of","human","aortic","endothelial","cells","(","HAEC",")","to","low","shear","stress","flow","patterns","is","associated","with","a","sustained","increase","in","the","activated","form","of","the","transcriptional","regulator","nuclear","factor-kappaB","(","NF-kappaB",")","."],"ner_tags":[0,0,0,0,0,0,0,7,8,8,8,0,5,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0]}
{"id":"8141","tokens":["In","response","to","hypoxia",",","sickle","red","blood","cells","(","SS","RBC",")","and","leukocytes","exhibit","increased","adherence","to","the","vascular","endothelium",",","while","diapedesis","of","leukocytes","through","the","blood","vessel","increases","."],"ner_tags":[0,0,0,0,0,7,8,8,8,0,7,8,0,0,7,0,0,0,0,0,0,0,0,0,0,0,7,0,0,0,0,0,0]}
{"id":"447","tokens":["By","these","functional","criteria",",","we","believe","we","have","identified","two","structurally","distinct",",","novel","inhibitors","of","NFAT","-1-mediated","transcription","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0]}
{"id":"15867","tokens":["Binding","of","AP-2","prevented","the","subsequent","binding","of","members","of","the","CREB\/ATF","family","to","an","adjacent","regulatory","motif","in","the","21","bp","repeat","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,0,9,10,0,0,1,2,2,0,0,1,2,2,0]}
{"id":"10334","tokens":["With","the","use","of","specific","antibodies","we","have","determined","the","composition","of","each","complex","using","electrophoretic","mobility","shift","assays","."],"ner_tags":[0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"4174","tokens":["Northern","blotting","experiments","indicated","that","regulation","predominantly","occurred","at","the","mRNA","level","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13054","tokens":["But","many","puzzles","of","the","drugs","remain","."],"ner_tags":[0,0,0,0,0,0,0,0]}
{"id":"9029","tokens":["All","three","RARS","patients","showed","monoclonal","PMNCs","."],"ner_tags":[0,0,7,0,0,0,7,0]}
{"id":"13683","tokens":["In","the","presence","of","ADP-activated","platelets",",","both","MCP-1","secretion","and","ICAM-1","surface","expression","were","significantly","increased","compared","with","nonstimulated","platelets","(","P","<","0.02",")","."],"ner_tags":[0,0,0,0,7,8,0,0,9,0,0,9,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0]}
{"id":"3195","tokens":["These","data","indicate","that","IL-4","signaling","occurs","in","the","absence","of","of","JAK3",",","but","is","comparatively","inefficient","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"3633","tokens":["Confirmation","of","the","unique","significance","of","zinc","for","immune","function","provides","a","better","understanding","of","the","mechanisms","of","specific","zinc-mediated","immune","modulation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14470","tokens":["Many","effects","of","lipopolysaccharide","(","LPS",")","on","gene","expression",",","including","that","of","human","immunodeficiency","virus","(","HIV",")",",","in","monocytic","cells","are","mediated","by","activation","of","kappa","B","DNA-binding","proteins","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0]}
{"id":"12839","tokens":["Fcgamma","receptor","-mediated","mitogen-activated","protein","kinase","activation","in","monocytes","is","independent","of","Ras","."],"ner_tags":[9,10,0,9,10,10,0,0,7,0,0,0,9,0]}
{"id":"11096","tokens":["The","inability","of","prolonged","stimulation","of","conventional","B-2","cells","with","anti-Ig",",","a","treatment","sufficient","to","induce","CD5","expression",",","to","result","in","sustained","STAT3","activation","suggests","that","STAT3","is","a","specific","nuclear","marker","for","B-1","cells","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,9,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0,0,0,9,0,0,0,0,0,0,7,8,0]}
{"id":"4889","tokens":["We","have","generated","rabbit","antisera","against","this","putative","p13MTCP1","protein","and","screened","for","expression","of","p13MTCP1","normal","lymphoid","tissues","and","33","cases","of","immature","and","mature","lymphoid","T-cell","proliferations","using","a","sensitive","Western","blot","assay","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,0,0,0,0,0,0,0,7,8,8,8,8,8,0,0,0,0,0,0,0]}
{"id":"5269","tokens":["Ad5","E1A","DNA","was","detected","by","polymerase","chain","reaction","in","five","of","six","animals","20","days","after","infection","and","in","five","of","five","animals","47","days","after","infection","."],"ner_tags":[1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13561","tokens":["Sequence-specific","DNA-binding","small","molecules","that","can","permeate","human","cells","potentially","could","regulate","transcription","of","specific","genes","."],"ner_tags":[0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0]}
{"id":"1914","tokens":["The","two","5'-most","distal","CArG","sequences","conferred","TPA","inducibility","."],"ner_tags":[0,0,1,2,2,2,0,0,0,0]}
{"id":"17864","tokens":["Northern","hybridization","data","showed","that","B4-2","is","not","a","lymphoid","specific","gene","and","is","expressed","in","a","hepatoma","cell","line","and","also","weakly","transcribed","or","absent","in","a","variety","of","other","cells","."],"ner_tags":[0,0,0,0,0,1,0,0,0,1,2,2,0,0,0,0,0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8043","tokens":["Furthermore",",","it","allows","for","discrimination","between","a","mixture","of","cells","that","differ","in","their","response","to","interferon-gamma","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"11401","tokens":["However",",","continuous","treatments","with","subcytotoxic","concentrations","of","etoposide","(","0.15","microM",")","and","ICRF-193","(","0.3","microM",")","produced","several","similar","effects",",","namely","decreased","cell","proliferation",",","accumulation","of","cells","at","G2",",","increase","in","cell","mass",",","and","induction","of","differentiation","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1491","tokens":["CD28","-dependent","induction","of","c-jun","expression","requires","protein","tyrosine","kinase","activity",",","but","does","not","depend","on","activation","of","a","phorbol","ester-responsive","protein","kinase","C","or","elevation","of","cytosolic","calcium","."],"ner_tags":[9,0,0,0,1,0,0,9,10,10,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0]}
{"id":"2595","tokens":["Signals","transduced","through","the","CD4","molecule","on","T","lymphocytes","activate","NF-kappa","B","."],"ner_tags":[0,0,0,0,9,10,0,7,8,0,9,10,0]}
{"id":"11195","tokens":["Hypermethylation","within","the","promoters","of","selected","genes","appears","to","be","especially","common","in","all","types","of","human","hematopoietic","neoplasms",",","and","is","usually","associated","with","inactivation","of","the","involved","gene","(","s",")","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6690","tokens":["STAT","is","a","family","of","transcription","factors","that","play","a","pivotal","role","in","cytokine-induced","functions","of","a","various","type","of","cells","."],"ner_tags":[9,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"1378","tokens":["Thapsigargin","(","TG",")",",","an","inhibitor","of","Ca","(","2+",")","-ATPase",",","depletes","intracellular","Ca2+","stores","and","induces","a","sustained","Ca2+","influx","without","altering","phosphatidyl","inositol","levels","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"14489","tokens":["Total","RNA","isolated","from","the","index","subject","'s","mononuclear","leukocytes","was","used","to","produce","first","strand","hGR","cDNAs",",","and","the","entire","hGR","cDNA","was","amplified","in","segments","and","sequenced","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,1,2,0,0,0,0,1,2,0,0,0,0,0,0,0]}
{"id":"448","tokens":["Transcriptional","regulation","of","the","vacuolar","H","(","+",")","-ATPase","B2","subunit","gene","in","differentiating","THP-1","cells","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,2,2,2,0,5,6,6,0]}
{"id":"7188","tokens":["The","glucocorticoid","receptor","cooperates","with","the","erythropoietin","receptor","and","c-Kit","to","enhance","and","sustain","proliferation","of","erythroid","progenitors","in","vitro","."],"ner_tags":[0,9,10,0,0,0,9,10,0,9,0,0,0,0,0,0,7,8,0,0,0]}
{"id":"17179","tokens":["Nuclear","run","on","transcription","of","the","c-jun",",","hck",",","and","actin","genes","."],"ner_tags":[0,0,0,0,0,0,1,0,1,0,0,1,2,0]}
{"id":"3383","tokens":["Alternative","mechanisms","include","the","possibility","that","NF-ATc","operates","on","some","cytoplasmic","anchor","or","that","other","proteins","that","are","controlled","by","calcineurin","carry","out","the","nuclear","import","of","NF-ATc","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,0]}
{"id":"665","tokens":["ZEBRA","is","a","bZIP","transcriptional","activator","which","binds","as","a","dimer","to","7-bp","response","elements","within","EBV","promoters","and","is","directly","involved","in","the","stimulation","of","virus","replication","at","the","EBV","lytic","origin","."],"ner_tags":[9,0,0,9,10,10,0,0,0,0,0,0,1,2,2,0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,0]}
{"id":"3553","tokens":["First",",","anti-CD45","antibodies","did","not","affect","basal","but","decreased","activated","levels","of","expression","from","the","HIV-1","LTR","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"6355","tokens":["Increased","IkappaB","expression","and","diminished","nuclear","NF-kappaB","in","human","mononuclear","cells","following","hydrocortisone","injection","."],"ner_tags":[0,9,0,0,0,9,10,0,7,8,8,0,0,0,0]}
{"id":"6775","tokens":["We","compared","this","sensitivity","to","analogue","effects","on","VDR","interacting","proteins",":","RXR",",","GRIP-1",",","and","DRIP205",",","a","subunit","of","the","DRIP","coactivator","complex","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,0,9,0,9,0,0,9,0,0,0,0,0,9,10,10,0]}
{"id":"10953","tokens":["The","unique","capacity","of","gamma-herpesvirus","to","amplify","the","viral","load","in","vivo","through","a","latent","growth-transforming","infection","may","have","rendered","these","agents","less","dependent","upon","viral","replication","as","a","means","of","successfully","colonizing","their","hosts","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"18479","tokens":["Binding","of","plasma","Factor","VII\/VIIa","to","the","tissue","factor","(","TF",")","receptor","initiates","the","coagulation","protease","cascades","."],"ner_tags":[0,0,9,10,10,0,0,9,10,10,10,10,10,0,0,9,10,0,0]}
{"id":"16540","tokens":["These","results","identify","TCF-1","as","a","T","cell-specific","transcription","factor",",","which","might","play","a","role","in","the","establishment","of","the","mature","T","cell","phenotype","."],"ner_tags":[0,0,0,9,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,0]}
{"id":"3796","tokens":["NGFI-B\/nur77","is","a","member","of","the","steroid","receptor","superfamily","."],"ner_tags":[9,0,0,0,0,0,9,10,10,0]}
{"id":"10425","tokens":["These","data","demonstrate","that","PML-RAR","alpha","and","PLZF-RAR","alpha","have","similar","(","inhibitory",")","effects","on","RA-independent","differentiation","and","opposite","(","stimulatory","or","inhibitory",")","effects","on","RA-dependent","differentiation","and","that","they","behave","in","vivo","as","RA-dependent","enhancers","or","inhibitors","of","RA-responsive","genes",",","respectively","."],"ner_tags":[0,0,0,0,9,10,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,1,2,0,0,0]}
{"id":"11155","tokens":["Neutrophil","elastase","(","NE",")","and","cathepsin","G","are","two","serine","proteinases","released","concomitantly","by","stimulated","polymorphonuclear","neutrophils","."],"ner_tags":[9,10,0,9,0,0,9,10,0,0,9,10,0,0,0,0,7,8,0]}
{"id":"15918","tokens":["The","data","suggest","that","differences","in","functional","responses","elicited","in","monocytes","by","all","three","factors","may","be","dependent","on","different","routes","on","nuclear","signalling","employed","by","the","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0]}
{"id":"16992","tokens":["We","have","cloned","and","characterized","a","mitogen-inducible","gene","isolated","from","human","T","cells","that","predicts","a","protein","of","968","amino","acids","."],"ner_tags":[0,0,0,0,0,0,1,2,0,0,7,8,8,0,0,0,0,0,9,10,10,0]}
{"id":"3539","tokens":["Thus","a","primary","effect","of","these","immunosuppressive","reagents","is","to","control","the","subcellular","localization","of","the","NF-AT","family","of","transcription","factors","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,9,10,0]}
{"id":"8669","tokens":["Here","we","show","that","JunB",",","but","not","the","other","Jun","family","members",",","was","selectively","induced","in","Th2","cells","and","not","in","Th1","cells","during","differentiation","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,9,10,10,0,0,0,0,0,7,8,0,0,0,7,8,0,0,0]}
{"id":"10130","tokens":["DNA","binding","studies","and","Ab","supershift","assays","revealed","that","different","combinations","of","factors","interact","with","these","motifs","in","B","cells","vs","T","cells","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,7,8,0]}
{"id":"10679","tokens":["Acute","promyelocytic","leukemia","(","APL",")","is","associated","with","reciprocal","chromosomal","translocations","involving","the","retinoic","acid","receptor","alpha","(","RARalpha",")","locus","on","chromosome","17","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,1,2,0]}
{"id":"12939","tokens":["In","addition",",","PEBP2betaMYH11","inhibited","neutrophilic","differentiation","in","colonies","derived","from","hematopoietic","progenitors","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,7,8,0]}
{"id":"17660","tokens":["Further",",","1",",","25","(","OH",")","2D3","inhibited","the","transcriptional","activity","of","NF-kappa","B","in","Jurkat","cells","transiently","transfected","with","a","construct","containing","four","tandem","repeats","of","the","NF-kappa","B","binding","sequence","of","the","immunoglobulin","kappa","light","chain","gene","linked","to","the","chloramphenicol","acetyltransferase","reporter","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,5,6,0,0,0,0,1,0,0,1,2,0,0,1,2,2,2,0,0,1,2,2,2,2,0,0,0,1,2,2,2,0]}
{"id":"15061","tokens":["Oct2","expression","was","unable","to","stimulate","a","multimerized","octamer","enhancer","element","in","HeLa","cells",",","however","."],"ner_tags":[9,0,0,0,0,0,0,1,2,2,2,0,5,6,0,0,0]}
{"id":"10461","tokens":["We","have","packaged","Flexi-12","into","a","recombinant","adeno-associated","virus","(","AAV",")","and","used","this","vector","to","infect","acute","myeloid","leukemic","(","AML",")","blasts","."],"ner_tags":[0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,8,8,8,8,8,0]}
{"id":"229","tokens":["This","inhibition","was","paralleled","by","reduced","monocyte","adhesion","to","endothelial","monolayers","in","nonstatic","assays",",","was","unaffected","by","cGMP","analogues",",","and","was","quantitatively","similar","after","stimulation","by","either","IL-1","alpha",",","IL-1","beta",",","IL-4",",","tumor","necrosis","factor","(","TNF","alpha",")",",","or","bacterial","lipopolysaccharide","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,10,0,9,0,9,10,10,0,9,10,0,0,0,0,0,0]}
{"id":"10805","tokens":["Involvement","of","Rel",",","Fos",",","and","Jun","proteins","in","binding","activity","to","the","IL-2","promoter","CD28","response","element\/AP-1","sequence","in","human","T","cells","."],"ner_tags":[0,0,9,10,10,10,10,10,10,0,0,0,0,0,1,2,2,2,2,2,0,7,8,8,0]}
{"id":"2209","tokens":["In","addition",",","transcripts","were","detected","in","RNA","prepared","from","tonsil","B","cells","and","in","situ","hybridization","studies","localized","them","in","the","germinal","center","region","of","adult","tonsil","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,7,8,8,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2067","tokens":["Recent","findings","suggest","an","involvement","of","reactive","oxygen","species","in","the","pathway","of","TPA","and","protein","kinase","C","leading","to","expression","of","c-fos","and","c-jun","mRNA","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,3,4,4,4,0]}
{"id":"11156","tokens":["We","previously","demonstrated","that","while","NE","by","itself","does","not","activate","human","platelets",",","it","strongly","enhances","the","weak","aggregation","induced","by","a","threshold","concentration","of","cathepsin","G","(","threshold","of","cathepsin","G",")","(","Renesto",",","P.",",","and","Chignard",",","M.","(","1993",")","Blood","82",",","139-144",")","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13969","tokens":["Biologic","effects","of","IL-13","on","primary","human","NK","and","T","cells","have","not","been","well","defined","."],"ner_tags":[0,0,0,9,0,7,8,8,8,8,8,0,0,0,0,0,0]}
{"id":"11304","tokens":["LEF-1","is","a","transcription","factor","that","participates","in","the","regulation","of","the","T-cell","receptor","alpha","(","TCR","alpha",")","enhancer","by","facilitating","the","assembly","of","multiple","proteins","into","a","higher","order","nucleoprotein","complex","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,0,9,10,0,0,0,0,9,10,0]}
{"id":"11747","tokens":["Characterization","of","a","mutant","cell","line","that","does","not","activate","NF-kappaB","in","response","to","multiple","stimuli","."],"ner_tags":[0,0,0,5,6,6,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"1398","tokens":["The","chromosome","14","region","translocated","or","rearranged","involves","approximately","350","kb","of","DNA","at","chromosome","band","14q32.1","."],"ner_tags":[0,1,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2911","tokens":["Therefore",",","to","evaluate","the","mechanism","of","TPA","responsiveness","of","the","SNE","motifs","and","of","a","related","16-bp","SEE","(","SRF\/ETS","element",")","motif","found","in","the","HCMV","and","chimpanzee","CMV","MIE","enhancers",",","we","have","examined","the","functional","responses","and","protein","binding","properties","of","multimerized","wild-type","and","mutant","elements","added","upstream","to","the","SCMV","MIE","or","simian","virus","40","minimal","promoter","regions","in","the","U-937",",","K-562",",","HL-60",",","THP-1",",","and","Jurkat","cell","lines","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,1,0,1,2,0,0,0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,0,0,0,0,1,2,0,1,2,2,2,2,2,0,0,5,0,5,0,5,0,5,0,0,5,6,6,0]}
{"id":"2615","tokens":["This","increase","in","p50","homodimers","coincides","with","an","increase","in","p105","mRNA",",","suggestive","of","a","transcriptional","up-regulation","of","p50","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,3,4,0,0,0,0,0,0,0,9,0]}
{"id":"10020","tokens":["The","increased","level","of","PLC","gamma","1","becomes","evident","after","90","min","of","IFN-beta","treatment","and","is","still","detectable","after","24","h","."],"ner_tags":[0,0,0,0,9,10,10,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0]}
{"id":"16420","tokens":["A","comparison","of","in","situ","hybridization","to","EBV","DNA","and","viral","capsid","antigen","staining","with","BZ1","reactivity","suggested","that","BZLF1","expression","precedes","rampant","virus","replication","."],"ner_tags":[0,0,0,0,0,0,0,1,2,0,9,10,10,0,0,9,0,0,0,9,0,0,0,0,0,0]}
{"id":"16707","tokens":["Moreover",",","platelet-activating","factor","was","capable","of","inducing","transcription","of","the","nuclear","proto-oncogenes","c-fos","and","c-jun","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,1,2,1,0,1,0]}
{"id":"11386","tokens":["Identification","of","nucleotide","sequences","that","regulate","transcription","of","the","MCF13","murine","leukemia","virus","long","terminal","repeat","in","activated","T","cells","."],"ner_tags":[0,0,1,2,0,0,0,0,0,0,0,0,0,1,2,2,0,0,7,8,0]}
{"id":"6489","tokens":["The","participation","of","STAT4","in","the","regulation","of","IRF-1","was","demonstrated","in","two","ways","."],"ner_tags":[0,0,0,9,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"5915","tokens":["The","strong","association","of","the","disease","with","an","epitope","within","the","HLA-DR","chain","shared","between","various","alleles","of","HLA-DR4","and","DR1","emphasizes","the","importance","of","antigen","presentation","."],"ner_tags":[0,0,0,0,0,0,0,0,9,0,0,9,10,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0]}
{"id":"10313","tokens":["During","myelopoiesis",",","which","includes","the","development","of","granulocytic","and","monocytic","lineages",",","transcription","factors","from","several","families","are","active",",","including","AML1\/CBF","beta",",","C\/EBP",",","Ets",",","c-Myb",",","HOX",",","and","MZF-1","."],"ner_tags":[0,0,0,0,0,0,0,0,7,8,8,8,0,9,10,0,0,0,0,0,0,0,1,2,0,1,0,1,0,1,0,1,0,0,1,0]}
{"id":"5314","tokens":["This","work","aimed","to","ascertain","the","role","of","kappaB-responsive","elements","of","the","human","immunodeficiency","virus","type","1","(","HIV-1",")","enhancer","not","only","in","early","initiation","but","also","in","long-term","maintenance","of","proviral","transcription","in","cells","of","the","monocytic","lineage","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0,0,1,2,2,2,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0]}
{"id":"1329","tokens":["Since","internal","sites","of","oxidant","production","have","been","shown","to","play","a","key","role","in","the","cytokine","-stimulated","activation","of","NF-kappa","B",",","and","since","tyrosine","kinase","and","phosphatase","activities","are","known","to","be","altered","by","oxidants",",","these","findings","suggest","that","intracellular","redox","status","controls","NF-kappa","B","activation","by","regulating","tyrosine","phosphorylation","event","(","s",")","within","the","common","step","of","the","NF-kappa","B","signal","transduction","pathway","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0]}
{"id":"1142","tokens":["The","effector","phase","of","cytotoxic","T","cell","responses","and","IL-2","-dependent","functions","are","inhibited","even","by","a","partial","depletion","of","the","intracellular","GSH","pool","."],"ner_tags":[0,0,0,0,7,8,8,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"6338","tokens":["Various","antioxidants","inhibit","NF-kappa","B","activation","in","response","to","these","stimuli","."],"ner_tags":[0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"33","tokens":["This","delay","is","associated","with","down-regulation","of","many","erythroid","cell-specific","genes",",","including","alpha-","and","beta-globin",",","band","3",",","band","4.1",",","and","the","erythroid","cell-specific","histone","H5","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,2,0,0,1,2,2,0,0,0,0,0,0,0,0,0,9,10,10,9,0]}
{"id":"549","tokens":["These","studies","identify","p21ras","as","a","target","of","NO","in","T","cells","and","suggest","that","NO","activates","p21ras","by","an","action","which","mimics","that","of","guanine","nucleotide","exchange","factors","."],"ner_tags":[0,0,0,1,0,0,0,0,0,0,7,8,0,0,0,0,0,1,0,0,0,0,0,0,0,9,10,10,10,0]}
{"id":"16466","tokens":["We","have","recently","identified","and","cloned","TCF-1",",","a","T","cell-specific","transcription","factor","with","specificity","for","the","AACAAAG","motif","in","the","CD3","epsilon","enhancer","and","for","the","TTCAAAG","motif","in","the","TCR","alpha","enhancer","."],"ner_tags":[0,0,0,0,0,0,9,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,1,2,2,0]}
{"id":"5205","tokens":["Here",",","we","present","clinical",",","cytogenetic",",","and","molecular","data","from","a","new","CMPD1\/SRA1","patient","with","t","(","6",";","17",")","(","q14",";","q24",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,2,2,0]}
{"id":"1043","tokens":["When","the","supplemented","cytokine","was","switched","from","GM-CSF","to","EPO",",","hemoglobin","synthesis","in","M-TAT\/GM-CSF","cells","increased","rapidly","(","within","5","h",")",",","and","the","level","of","GATA-1","mRNA","increased","."],"ner_tags":[0,0,0,9,0,0,0,9,0,9,0,9,0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,3,4,0,0]}
{"id":"7215","tokens":["Finally",",","proliferation","induced","by","both","IL-2","-and","IL-3","was","significantly","inhibited","in","the","presence","of","SOCS-3","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"7181","tokens":["CTLA-4","-Mediated","inhibition","of","early","events","of","T","cell","proliferation","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0]}
{"id":"1632","tokens":["This","locus","encodes","a","transcriptional","trans-activator","required","for","the","constitutive","expression","of","major","histocompatibility","complex","(","MHC",")","class","II","genes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,1,2,2,2,2,2,2,2,2,0]}
{"id":"8508","tokens":["It","is","now","well","appreciated","that","chronic","gut","inflammation","is","characterized","by","enhanced","production","of","reactive","metabolites","of","oxygen","and","nitrogen","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"2236","tokens":["The","I","kappa","B","gamma","isoforms","also","display","differences","in","specificity","and","affinity","for","Rel\/NF-kappa","B","proteins","."],"ner_tags":[0,9,10,10,10,10,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"3546","tokens":["These","findings","thus","reveal","the","presence","of","a","second","inducible","autoregulated","inhibitory","pathway","that","helps","ensure","the","rapid","but","transient","action","of","nuclear","NF-kappa","B","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0]}
{"id":"4337","tokens":["The","current","study","examined","the","effects","of","oxidative","stress","on","transcriptional","activities","mediated","by","c-Fos\/c-Jun","AP-1","and","the","nuclear","factor","of","activated","T","cells","(","NF-AT",")","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,9,0,0,9,10,10,10,10,10,0,9,0,0]}
{"id":"18400","tokens":["Regulation","of","IkB","alpha","phosphorylation","by","PKC-","and","Ca","(","2+",")","-dependent","signal","transduction","pathways","."],"ner_tags":[0,0,9,10,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13791","tokens":["Activation","of","Janus","tyrosine","kinases","(","Jak",")","and","Signal","transducers","and","activators","of","transcription","(","Stat",")","after","ligation","of","major","histocompatibility","complex","class","I","(","MHC-I",")","was","explored","in","Jurkat","T","cells","."],"ner_tags":[0,0,9,10,10,0,9,0,0,9,10,10,10,10,10,0,9,0,0,0,0,9,10,10,10,10,0,9,0,0,0,0,5,6,6,0]}
{"id":"11639","tokens":["Examination","of","CIITA","mRNA","in","IK","stably","transfected","clones","revealed","a","marked","reduction","of","CIITA","mRNA","transcription","."],"ner_tags":[0,0,3,4,0,9,0,0,0,0,0,0,0,0,3,4,0,0]}
{"id":"8803","tokens":["METHODS","."],"ner_tags":[0,0]}
{"id":"1225","tokens":["Taken","together",",","we","report","that","IL-2","induces","tyrosine","phosphorylation","and","subsequent","nuclear","translocation","of","stat3","and","an","as","yet","undefined","84-kDa","protein","in","antigen-specific","human","T","cell","lines","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0,0,9,10,0,5,6,6,6,6,0]}
{"id":"15987","tokens":["This","protein-DNA","complex","comigrated","with","the","complex","obtained","with","the","purified","human","p65","NF-kappa","B","subunit","and","binding","was","inhibited","by","I","kappa","B-alpha","and","-beta","proteins","."],"ner_tags":[0,9,10,0,0,0,0,0,0,0,9,10,10,10,10,10,0,0,0,0,0,9,10,10,0,0,0,0]}
{"id":"4577","tokens":["Electrophoretic","mobility","shift","assays","showed","that","IL-4",",","but","not","IL-10",",","inhibited","nuclear","NF-kappaB","activity",",","and","that","IL-4","and","IL-10","did","not","affect","NF-","IL-6","activity","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,9,0,0,0,9,0,0,0,0,9,0,9,0,0,0,0,9,0,0]}
{"id":"1934","tokens":["The","activity","of","the","immunoglobulin","heavy-chain","(","IgH",")","enhancer","is","restricted","to","B","cells",",","although","it","binds","both","B-cell-restricted","and","ubiquitous","transcription","factors","."],"ner_tags":[0,0,0,0,1,2,2,2,2,2,0,0,0,7,8,0,0,0,0,0,9,10,10,10,10,0]}
{"id":"8116","tokens":["We","demonstrate","the","nuclear","localization","of","I","(","kappa",")","B","(","alpha",")","in","PBL","by","different","techniques",":","Western","blot",",","indirect","immunofluorescence","and","electron","microscopy","."],"ner_tags":[0,0,0,0,0,0,9,10,10,10,10,10,10,10,0,7,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"8700","tokens":["Furthermore",",","GRbeta","did","not","antagonize","the","repressive","effects","of","GRalpha","on","IL-2","promoter","activity","."],"ner_tags":[0,0,9,0,0,0,0,0,0,0,9,0,1,2,0,0]}
{"id":"16460","tokens":["In","T","cells","and","T","cell","lines",",","NF-kB","is","bound","to","a","cytoplasmic","proteic","inhibitor",",","the","IkB","."],"ner_tags":[0,7,8,0,5,6,6,0,9,0,0,0,0,9,10,10,0,0,9,0]}
{"id":"16031","tokens":["Our","results","suggest","that","overexpression","of","v-erbA","is","required","for","its","function","as","an","oncoprotein","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,0,9,0]}
{"id":"12282","tokens":["These","results","provide","evidence","that","promonocytic","THP-1","cells","require","prestimulation","in","order","to","activate","HUVEC","and","that","TNF","alpha","contributes","to","this","phenomenon","."],"ner_tags":[0,0,0,0,0,5,6,6,0,0,0,0,0,0,7,0,0,9,10,0,0,0,0,0]}
{"id":"848","tokens":["Taken","together",",","these","results","suggest","that","inhibition","of","NF","kappa","B","activation","may","be","an","important","mechanism","for","IL-10","suppression","of","cytokine","gene","transcription","in","human","monocytes","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,9,0,0,0,0,0,0,7,8,0]}
{"id":"11688","tokens":["Thus",",","the","binding","of","V3","loop","of","gp120","to","the","cell","surface","molecule","(","s",")","appears","to","affect","intracellular","IL-2","signaling",",","which","leads","to","the","suppression","of","IL-2","-induced","T","cell","growth"],"ner_tags":[0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"3959","tokens":["Abnormalities","in","the","p16",",","p15","and","CDK4","genes","that","regulate","transition","through","the","G1","phase","of","the","cell","cycle","have","been","implicated","in","the","malignant","progression","of","astrocytomas","."],"ner_tags":[0,0,0,1,2,2,2,2,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13264","tokens":["This","stimulation","is","abrogated","by","mutations","affecting","the","E2F-binding","sites","."],"ner_tags":[0,0,0,0,0,0,0,0,1,2,0]}
{"id":"10796","tokens":["The","combined","treatment","resulted","in","more","durable","inhibition","of","HIV-1","replication","than","was","seen","with","the","NF-kappa","B","inhibitors","alone","or","the","anti-","Tat","sFv","intrabodies","alone","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,9,10,10,0,0]}
{"id":"4759","tokens":["Stimulation","of","U1","cells","by","LPS","alone","induced","minimal","levels","of","HIV","expression",",","which","was","significantly","enhanced","by","granulocyte-macrophage","colony-stimulating","factor","(","GM-CSF",")","."],"ner_tags":[0,0,5,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0]}
{"id":"13246","tokens":["The","IL-4-induced","complex","reacted","with","anti-STAT","(","signal","transducers","and","activators","of","transcription",")","6",",","resulting","in","a","supershift","whereas","the","formation","of","the","IFN-gamma-induced","complex","was","inhibited","by","anti-STAT","1","."],"ner_tags":[0,9,10,0,0,9,10,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,9,10,0]}
{"id":"14001","tokens":["EKLF","is","required","for","integrity","of","the","chromatin","structure","at","the","beta-like","globin","locus",",","and","it","interacts","with","a","positive-acting","factor","in","vivo","."],"ner_tags":[9,0,0,0,0,0,0,0,0,0,0,1,2,2,0,0,0,0,0,0,9,10,0,0,0]}
{"id":"17780","tokens":["In","addition",",","pretreatment","of","the","cells","with","the","proteasome","inhibitor","N-Ac-Leu-Leu-norleucinal","inhibits","this","ligand-induced","degradation","and",",","in","agreement","with","previous","studies",",","stabilizes","a","hyperphosphorylated","form","of","the","human","I","kappa","B","alpha","protein","."],"ner_tags":[0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,10,10,0]}
{"id":"8070","tokens":["BACKGROUND",":","The","Bcl-6","gene","product",",","a","nuclear","phosphoprotein",",","is","expressed","independently","of","Bcl-6","gene","rearrangement","."],"ner_tags":[0,0,0,9,10,10,0,0,9,10,0,0,0,0,0,9,0,0,0]}
{"id":"3084","tokens":["Nuclear","factor","kappa","B","(","NF-kappa","B",";","heterodimer","of","p50","and","p65",")","proteins","have","been","suggested","to","play","an","important","role","in","gene","transcription","of","inflammatory","mediators","when","monocytes","are","stimulated","with","lipopolysaccharide","."],"ner_tags":[9,10,10,10,10,10,10,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,7,0,0,0,0,0]}
{"id":"1629","tokens":["The","phosphorylated","tyrosine","residue","itself","is","important","for","the","protein-protein","interaction","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3331","tokens":["CD14","-mediated","signal","pathway","of","Porphyromonas","gingivalis","lipopolysaccharide","in","human","gingival","fibroblasts","."],"ner_tags":[9,0,0,0,0,0,0,0,0,7,8,8,0]}
{"id":"15929","tokens":["The","sites","and","their","corresponding","nuclear","binding","factors","include",":","NF-kappa","B",",","AP-1",",","AP-3",",","OCT-1",",","and","NF-AT","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,9,0,9,0,0,9,0]}
{"id":"7370","tokens":["A","series","of","5","'","deletion","derivatives","of","the","upstream","regulatory","region","were","used","in","transient","transfection","assays","to","identify","promoter","elements","required","for","basal","and","inducible","gene","expression","."],"ner_tags":[0,0,0,1,2,2,2,0,0,1,2,2,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0]}
{"id":"12700","tokens":["We","find","that","mutation","of","these","elements",",","and","particularly","the","GATA","elements",",","results","in","a","decrease","or","complete","loss","of","DNase","I","hypersensitivity","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,1,2,0,0,0,0,0,0,0,0,0,9,10,0,0]}
{"id":"255","tokens":["Jak2","kinase","has","been","shown","to","phosphorylate","STAT","nuclear","proteins","."],"ner_tags":[9,10,0,0,0,0,0,9,10,10,0]}
{"id":"12033","tokens":["Therefore",",","activation","of","NFAT","and","AP-1","is","insufficient","for","IL-2","promoter","activation","."],"ner_tags":[0,0,0,0,9,0,9,0,0,0,1,2,0,0]}
{"id":"6045","tokens":["As","a","consequence",",","B-lymphoid","tissues","are","mosaic","with","regard","to","the","transcribed","allele",",","and","heterozygous","mutation","of","Pax5","therefore","results","in","deletion","of","B","lymphocytes","expressing","only","the","mutant","allele","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,9,0,0,0,0,0,7,8,0,0,0,1,2,0]}
{"id":"4287","tokens":["Second",",","a","glutathione-S-transferase","(","GST",")","affinity-binding","assay","showed","that","the","interaction","of","holo-","TFIIA","with","GST-Tax","was","20-fold","higher","than","that","observed","with","either","the","GST-Tax","M32","activation","mutant","or","the","GST","control","."],"ner_tags":[0,0,0,0,0,9,0,0,0,0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0]}
{"id":"4632","tokens":["These","receptor","functions","required","the","presence","of","the","box","3","motifs",",","as","shown","by","the","analysis","of","the","mouse","IL-10R","constructs","containing","progressively","truncated","cytoplasmic","domains","."],"ner_tags":[0,0,0,0,0,0,0,0,9,10,10,0,0,0,0,0,0,0,0,0,9,0,0,9,10,10,10,0]}
{"id":"7932","tokens":["Western","blot","experiments","showed","that","p21","(","WAF1\/CIP1",")","protein","levels","increased","and","became","detectable","after","12","hours","of","1",",","25","(","OH",")","2D3","treatment","and","induction","of","p27","(","KIP1",")","protein","was","much","more","gradual","and","sustained","in","UF-1","cells","."],"ner_tags":[0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"4202","tokens":["To","further","analyze","potential","cross","points","between","positively","and","negatively","regulating","signaling","pathways","in","T","cells",",","we","tested","the","effects","of","activators","of","the","adenylate","cyclase","or","PKA","on","two","parallel","mitogen-activated","protein","kinase","signaling","pathways","mediated","by","extracellular","signal-regulated","kinase","(","ERK",")","and","c-Jun","N-terminal","kinase","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0,0,0,9,10,10,0,9,0,0,9,10,10,0]}
{"id":"6091","tokens":["Peroxisome","proliferator-activated","receptor","activators","target","human","endothelial","cells","to","inhibit","leukocyte","-endothelial","cell","interaction","."],"ner_tags":[9,10,10,10,0,7,8,8,0,0,7,7,8,0,0]}
{"id":"6185","tokens":["Taken","together",",","our","findings","suggest","that","tumor-derived","gangliosides","may","blunt","antitumor","immune","responses","in","patients","with","RCCs","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"13325","tokens":["The","expression","of","the","murine","interleukin","(","IL",")","-2","receptor","alpha","chain\/CD25","is","strongly","induced","at","the","transcriptional","level","after","T","cell","activation","."],"ner_tags":[0,0,0,0,9,10,10,10,10,10,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7830","tokens":["Human","immunodeficiency","virus-associated","Hodgkin","'s","disease","(","HIV-HD",")","displays","several","peculiarities","when","compared","with","HD","of","the","general","population","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"146","tokens":["(","ABSTRACT","TRUNCATED","AT","250","WORDS",")"],"ner_tags":[0,0,0,0,0,0,0]}
{"id":"6715","tokens":["Blocking","NF-kappaB","in","the","rheumatoid","joint","thus","has","a","very","beneficial","profile",",","reducing","both","the","inflammatory","response","and","the","tissue","destruction","."],"ner_tags":[0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15639","tokens":["The","work","reviewed","in","this","article","separates","T","cell","development","into","four","phases","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"15823","tokens":["We","also","showed","that","this","silencer","has","stronger","inhibitory","activity","in","HeLa","cells",",","as","compared","to","K562","human","erythroleukemia","cells","."],"ner_tags":[0,0,0,0,0,1,0,0,0,0,0,5,6,0,0,0,0,5,6,6,6,0]}
{"id":"4808","tokens":["The","protein","products","of","the","c-fos","(","p62c-fos",")","and","c-jun","(","p39c-jun",")","genes","are","members","of","the","AP-1","transcription","factor","family","and","are","thought","to","play","important","roles","in","the","regulation","of","gene","expression","during","the","cell","cycle","."],"ner_tags":[0,0,0,0,0,1,0,9,0,0,1,0,9,0,0,0,0,0,0,9,10,10,10,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7477","tokens":["Together",",","these","results","demonstrate","that","ER","and","PR","can","be","activated","by","endogenous","or","exogenous","ligands","to","induce","a","genetic","response","that","impairs","TNF-alpha","-induced","apoptosis","in","U937","cells","."],"ner_tags":[0,0,0,0,0,0,9,0,9,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,5,6,0]}
{"id":"720","tokens":["The","function","of","the","zeta-globin","promoter","was","studied","using","a","series","of","zeta-globin","promoter","deletion","constructs","to","drive","luciferase","expression","in","transiently","transfected","human","erythroleukemia","cells","."],"ner_tags":[0,0,0,0,1,2,0,0,0,0,0,0,1,2,2,2,0,0,9,0,0,5,6,6,6,6,0]}
{"id":"2253","tokens":["LBR","'s","nucleoplasmic","domain","is","encoded","by","exons","1-4",",","and","its","hydrophobic","domain",",","with","eight","putative","transmembrane","segments",",","is","encoded","by","exons","5-13","."],"ner_tags":[9,0,9,10,0,0,0,1,2,0,0,0,9,10,0,0,0,0,9,10,0,0,0,0,1,2,0]}
{"id":"5683","tokens":["These","data","indicate","that","E2F-1","can","prevent","terminal","differentiation",",","probably","through","its","cell","cycle-stimulatory","activity","."],"ner_tags":[0,0,0,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"7575","tokens":["Interestingly",",","although","mRNA","expression","of","Smad6","was","induced","by","activin","A","in","HS-72","cells",",","Smad6","showed","no","antagonistic","effect","on","activin","A-induced","growth","arrest","and","apoptosis","."],"ner_tags":[0,0,0,0,0,0,9,0,0,0,0,0,0,5,6,0,9,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"17246","tokens":["The","drug","concentrations","required","for","antagonism","may","be","explained","by","the","relative","affinity","of","the","drugs","to",",","and","by","the","abundance","of",",","the","immunophilin","FKBP","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,9,0]}
{"id":"4993","tokens":["In","a","panel","of","32","B-cell","lines",",","A-myb","was","very","strongly","expressed","in","most","Burkitt","'s","lymphoma","(","BL",")","cell","lines",",","but","weak","or","negative","in","2","pre-B","acute","lymphoblastic","leukemia","(","ALL",")",",","4","non-Hodgkin","'s","lymphoma","(","NHL",")",",","6","Epstein-Barr","virus-immortalized","lymphoblastoid","cell","lines",",","and","6","myeloma","lines","."],"ner_tags":[0,0,0,0,0,5,6,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,6,6,6,0,0,0,5,6,0]}
{"id":"18129","tokens":["Similar","levels","of","hTR","beta","1","mRNA","levels","were","detected","in","thyroid","gland","from","euthyroid","patients","."],"ner_tags":[0,0,0,3,4,4,4,0,0,0,0,0,0,0,0,0,0]}
{"id":"9428","tokens":["These","abnormalities","can","be","reproduced","by","transfection","of","cell","lines","with","the","GCR-beta","gene","resulting","in","significant","reduction","of","their","GCR-alpha","DNA","binding","capacity","."],"ner_tags":[0,0,0,0,0,0,0,0,5,6,0,0,9,0,0,0,0,0,0,0,9,0,0,0,0]}
{"id":"9373","tokens":["Cotransfection","of","Sp3","along","with","CD11c","promoter-luciferase","constructs","into","Sp-deficient","Drosophila","Schneider","2","cells","showed","that","Sp3","could","activate","the","CD11c","promoter","."],"ner_tags":[0,0,9,0,0,1,2,2,0,5,6,6,6,6,0,0,9,0,0,0,1,2,0]}
{"id":"223","tokens":["Whereas","the","Jak","kinases","Jak1","and","Jak3","and","the","signal","transducer","and","activator","of","transcription","proteins","Stat3","and","Stat5","are","activated","in","normal","T","cells","in","response","to","IL-2",",","this","signaling","pathway","was","constitutively","activated","in","HTLV-I-transformed","cells","."],"ner_tags":[0,0,9,10,9,0,9,0,0,0,0,0,0,0,9,10,9,0,9,0,0,0,7,8,8,0,0,0,9,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"3734","tokens":["Seventeen","microsatellite","markers","that","span","the","common","deleted","region","were","used","to","search","for","loss","of","heterozygosity","in","granulocyte","DNA","."],"ner_tags":[0,1,2,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"3250","tokens":["The","human","myeloid","leukemia","cell","lines",",","HL-60",",","U937",",","and","THP-1",",","express","similar","levels","of","immunochemically","detectable","MNDA","."],"ner_tags":[0,5,6,6,6,6,0,5,0,5,0,0,5,0,0,0,0,0,0,0,9,0]}
{"id":"5015","tokens":["In","promoter","transactivation","as","well","as","primary","B","cell","transformation","assays","these","chimeric","EBNA2","proteins","are","able","to","substitute","for","wild-type","EBNA2","in","the","presence","of","oestrogen","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0,9,10,0,0,0,0,0,0]}
{"id":"14959","tokens":["In","vitro","DNase","I","footprinting","analysis","revealed","six","hGATA-3","binding","sites","in","the","U3","region","(","the","transcriptional","regulatory","domain",")","of","the","HIV-1","LTR","."],"ner_tags":[0,0,9,10,0,0,0,0,1,2,2,0,0,1,2,0,0,1,2,2,0,0,0,1,2,0]}
{"id":"9939","tokens":["Cross-linking","of","this","lymphocyte-specific","protein",",","designated","TACI","(","transmembrane","activator","and","CAML-interactor",")",",","on","the","surface","of","transfected","Jurkat","cells","with","TACI-specific","antibodies","led","to","activation","of","the","transcription","factors","NF-AT",",","AP-1",",","and","NFkappaB","."],"ner_tags":[0,0,0,9,10,0,0,9,0,9,10,10,10,0,0,0,0,0,0,5,6,6,0,9,10,0,0,0,0,0,9,10,9,0,9,0,0,9,0]}
{"id":"17344","tokens":["No","correlations","were","found","between","all","or","high","levels","of","amplification","of","each","oncogene","separately","or","combined","with","T",",","N",",","grade",",","multifocality","of","tumor",",","or","associated","carcinoma","in","situ","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"682","tokens":["Almost","25","%","of","patients","with","T-cell","acute","lymphoblastic","leukemia","(","T-ALL",")","have","tumor-specific","rearrangements","of","the","TAL1","gene","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,2,0]}
{"id":"375","tokens":["We","show","that","in","transiently","transfected","erythroid","cells",",","deletion","of","the","alpha-globin","G","+","C-rich","5","'","flanking","region","has","no","effect","on","alpha-globin","promoter","activity","."],"ner_tags":[0,0,0,0,5,6,6,6,0,0,0,0,1,2,2,2,2,2,2,2,0,0,0,0,1,2,0,0]}
{"id":"17343","tokens":["In","a","non-parametric","test","(","Kruskal-Wallis",")","a","strong","negative","association","was","found","between","high","levels","of","c-erbB2","amplification","and","absence","of","estrogen","receptor","(","ER",")","(","P","=",".0009",")","or","progesterone","receptor","(","PR",")","(","P","=",".011",")","expression","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9,10,0,9,0,0,0,0,0,0,0,0]}
{"id":"9980","tokens":["Epstein-Barr","virus","latent","membrane","protein-1","triggers","AP-1","activity","via","the","c-Jun","N-terminal","kinase","cascade","."],"ner_tags":[0,0,9,10,10,0,9,0,0,0,9,0,0,0,0]}
{"id":"9176","tokens":["FMS","patients","display","a","hyperreactive","pituitary","adrenocorticotropic","hormone","(","ACTH",")","release","in","response","to","corticotropin-releasing","hormone","(","CRH",")","and","to","insulin-induced","hypoglycemia","."],"ner_tags":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]}
{"id":"3705","tokens":["The","NB4","cell","line",",","which","is","derived","from","the","bone","marrow","of","a","patient","with","APL","during","relapse",",","can","be","used","as","a","model","system","to","study","the","growth","and","differentiation","of","APL","cells","."],"ner_tags":[0,5,6,6,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5,6,0]}
{"id":"5365","tokens":["In","vivo","anergized","CD4+","T","cells","express","perturbed","AP-1","and","NF-kappa","B","transcription","factors","."],"ner_tags":[0,0,5,6,6,6,0,0,0,0,9,10,9,10,0]}
{"id":"13749","tokens":["Diminished","NF-kappaB","activity","has","been","shown","to","occur","in","T","cells","with","aging",",","suggesting","that","impaired","activation","of","NF-kappaB","might","occur","during","cellular","senescence","."],"ner_tags":[0,9,0,0,0,0,0,0,0,7,8,0,0,0,0,0,0,0,0,9,0,0,0,0,0,0]}
{"id":"18394","tokens":["Cells","expressing","the","E1A","oncoprotein","were","selectively","killed","by","unstimulated","NK","cells",",","while","the","same","parental","cells","but","expressing","the","HPV","type","16","(","HPV-16",")","or","HPV-18","E7","oncoprotein","were","resistant","to","NK","cell","lysis","."],"ner_tags":[0,0,0,9,10,0,0,0,0,5,6,6,0,0,0,0,7,8,0,0,0,0,0,0,0,0,0,0,0,9,10,0,0,0,0,0,0,0]}
{"id":"11490","tokens":["Putative","cis-acting","control","elements","present","within","a","300-bp","core","promoter","included","two","ets","sites",",","an","Sp1","site",",","tandem","E-box","domains",",","two","GATA-associated","sites","(","CACCC",")",",","an","AP-2","binding","site",",","and","a","GATA","element","at","-24","."],"ner_tags":[0,1,2,2,0,0,0,1,2,2,0,0,1,2,0,0,1,2,0,0,1,2,0,0,1,2,0,0,0,0,0,1,2,2,0,0,0,1,2,0,1,0]}