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-{"query_id": "7", "query_text": "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "negative": "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "negatives": ["Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Pyridostatin delays checkpoint activation."], "hard_negatives": ["10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Some countries have achieved the goal of eradicting malaria.", "Malaria has a low vectorial capacity.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Suboptimal nutrition is a leading cause of chronic disease", "Incidence of sepsis has remained stable between 2009-2014.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy."], "hard_negative": "10-20% of people with severe mental disorder receive no treatment in low and middle income countries."}
-{"query_id": "8", "query_text": "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "negative": "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "negatives": ["Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Distant CREs are more conserved among species.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Alirocumab treatment increases apo(a) fractional clearance rate."], "hard_negatives": ["25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Side effects associated with antidepressants decrease risk of stroke.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Higher initial mortality is associated with antidepressant use.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Hypoglycemia decreases the risk of dementia."], "hard_negative": "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."}
-{"query_id": "16", "query_text": "50% of patients exposed to radiation have activated markers of myofibroblasts.", "negative": "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "negatives": ["The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "p16INK4A accumulation is encoded by CDKN2A.", "Short British students are bullied more than control British students.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Incidence of sepsis has remained stable between 2009-2014.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation."], "hard_negatives": ["50% of patients exposed to radiation have activated markers of myofibroblasts.", "Metastases have genomic aberrations different than those of the primary tumor.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Notch signalling can occur between tumor cells and stromal cells.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus."], "hard_negative": "50% of patients exposed to radiation have activated markers of myofibroblasts."}
-{"query_id": "23", "query_text": "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "negative": "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "negatives": ["Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Choice of specialty is not influenced by debt accrued from medical training.", "Patients in stable partnerships have a slower progression from HIV to death.", "Aspirin encourages the production of PGE2.", "Choice of specialty is not influenced by debt accrued from medical training.", "Aspirin encourages the production of PGE2.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion."], "hard_negatives": ["8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Incidence of sepsis has remained stable between 2009-2014.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Teaching hospitals provide better care than non-teaching hospitals.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006."], "hard_negative": "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics."}
-{"query_id": "29", "query_text": "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "negative": "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "negatives": ["Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Malaria has a low vectorial capacity.", "In the UK, drowning affects boys at a higher rate than girls.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice."], "hard_negatives": ["A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants decrease risk of stroke.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Higher initial mortality is associated with antidepressant use.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals."], "hard_negative": "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome."}
-{"query_id": "31", "query_text": "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "negative": "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "negatives": ["Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Foxp3 displaces Foxo1 on chromatin", "Pyridostatin delays checkpoint activation.", "Bronchial responsiveness is higher in the summer than in the winter.", "Major vault protein (MVP) functions to decrease tumor aggression.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response."], "hard_negatives": ["A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Some countries have achieved the goal of eradicting malaria.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Sustained transmission of Avian influenza A between humans is not observed.", "Patients in stable partnerships have a slower progression from HIV to death.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "There is no relation between lupus erythematosus and cardiovascular disease", "Having a main partner lowers survival rates in HIV patients.", "Having a main partner increases survival rates in HIV patients."], "hard_negative": "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine."}
-{"query_id": "33", "query_text": "A deficiency of folate decreases blood levels of homocysteine.", "negative": "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "negatives": ["Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Having a main partner lowers survival rates in HIV patients.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion."], "hard_negatives": ["A deficiency of folate decreases blood levels of homocysteine.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Autophagy deficiency in the liver protects from insulin resistance.", "NR5A2 is important in bile acid homeostasis in humans.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Increased calcium levels repress transgultaminase activity.", "High levels of copeptin increase risk of diabetes.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "N348I mutations decrease resistance to zidovudine (AZT).", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries."], "hard_negative": "A deficiency of folate decreases blood levels of homocysteine."}
-{"query_id": "38", "query_text": "A deficiency of vitamin B6 increases blood levels of homocysteine.", "negative": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "negatives": ["Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Gastric lavage shows no benefit for acute paraquat poisoning."], "hard_negatives": ["A deficiency of vitamin B6 increases blood levels of homocysteine.", "A deficiency of folate decreases blood levels of homocysteine.", "NR5A2 is important in bile acid homeostasis in humans.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species."], "hard_negative": "A deficiency of vitamin B6 increases blood levels of homocysteine."}
-{"query_id": "59", "query_text": "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "negative": "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "negatives": ["Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "The innate immune response is efficient at removing small numbers of parasites.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Colloid exposure has no effect on morbidity.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Genetic deletion of JAM-A decreases gut permeability."], "hard_negatives": ["APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "DUSP4 downregulation activates the Ras-ERK pathway", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "IL-10 production by monocytes encourages CD4 + T cell response.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Foxp3 displaces Foxo1 on chromatin", "The minor G allele of FOXO3 represses IL-10.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death."], "hard_negative": "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation."}
-{"query_id": "65", "query_text": "AZT given with ribavirin alleviates anemia.", "negative": "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "negatives": ["Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Physical injury activates transgultaminase activity.", "G-CSF prevents MDSCs from infiltrating tumors.", "Patients in stable partnerships have a slower progression from HIV to death.", "NAC encourages the generation of angiotensin-converting enzyme.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Having a main partner lowers survival rates in HIV patients."], "hard_negatives": ["AZT given with ribavirin alleviates anemia.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Rapamycin treatment raises G-CSF levels.", "N348I mutations decrease resistance to zidovudine (AZT).", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negative": "AZT given with ribavirin alleviates anemia."}
-{"query_id": "83", "query_text": "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Lithium damages function in the SCA1 mouse model", "Mitochondria play a major role in calcium homeostasis.", "Bariatric surgery has a deleterious impact on mental health.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "Obesity decreases life expectancy.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers."], "hard_negatives": ["Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Excess nitric oxide is responsible for vasospasm.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels."], "hard_negative": "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression."}
-{"query_id": "84", "query_text": "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "negative": "Obesity is determined in part by genetic factors.", "negatives": ["Obesity is determined in part by genetic factors.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Higher initial mortality is associated with antidepressant use.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Foxp3 displaces Foxo1 on chromatin", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring."], "hard_negatives": ["Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Autophagy increases in aged organisms.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "F4/80+ macrophages are located in the periosteum.", "Myelin sheaths play an important role in trophic support.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts."], "hard_negative": "Adult tissue-resident macrophages are maintained independent of circulating monocytes."}
-{"query_id": "87", "query_text": "Adult tissue-resident macrophages possess a self-renewing capacity.", "negative": "Participating in six months of physical activity impairs cognitive functioning.", "negatives": ["Participating in six months of physical activity impairs cognitive functioning.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Cellular aging is uncorrelated with an older appearance.", "Suboptimal nutrition is a leading cause of chronic disease", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Incidence of sepsis has remained stable between 2009-2014.", "p16INK4A accumulation is encoded by CDKN2A.", "CENP-B inhibits heterochromatin formation"], "hard_negatives": ["Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Autophagy increases in aged organisms.", "Myelin sheaths play an important role in trophic support.", "Cellular aging is uncorrelated with an older appearance.", "F4/80+ macrophages are located in the periosteum.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Mitochondria play a major role in calcium homeostasis.", "Mitochondria are uninvolved in processes related to cell signaling.", "The innate immune response is efficient at removing small numbers of parasites."], "hard_negative": "Adult tissue-resident macrophages possess a self-renewing capacity."}
-{"query_id": "97", "query_text": "Alirocumab treatment increases apo(a) fractional clearance rate.", "negative": "Piezo1 channels are sensors for cell crowding in epithelial cells.", "negatives": ["Piezo1 channels are sensors for cell crowding in epithelial cells.", "Serotonin receptors play a role in depression", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Lithium damages function in the SCA1 mouse model", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress."], "hard_negatives": ["Alirocumab treatment increases apo(a) fractional clearance rate.", "AZT given with ribavirin alleviates anemia.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Higher initial mortality is associated with antidepressant use.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Aspirin encourages the production of PGE2.", "Genetic deletion of JAM-A decreases gut permeability.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer"], "hard_negative": "Alirocumab treatment increases apo(a) fractional clearance rate."}
-{"query_id": "101", "query_text": "All phenotypes associated with reduced IIS require the gene daf-16.", "negative": "The number of Ndc80 complexes varies with cell cycle timing.", "negatives": ["The number of Ndc80 complexes varies with cell cycle timing.", "Lithium damages function in the SCA1 mouse model", "Participating in six months of physical activity impairs cognitive functioning.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "NLRP12 is a positive regulator of T-cell receptor activation."], "hard_negatives": ["All phenotypes associated with reduced IIS require the gene daf-16.", "The minor G allele of FOXO3 represses IL-10.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "A deficiency of folate decreases blood levels of homocysteine.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367."], "hard_negative": "All phenotypes associated with reduced IIS require the gene daf-16."}
-{"query_id": "102", "query_text": "All six cathelicidins are located on chromosome two.", "negative": "N348I mutations decrease resistance to zidovudine (AZT).", "negatives": ["N348I mutations decrease resistance to zidovudine (AZT).", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "NR5A2 is important in bile acid homeostasis in humans.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Incidence rates of cervical cancer have increased over time.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Short British students are bullied more than control British students.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values."], "hard_negatives": ["All six cathelicidins are located on chromosome two.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "The minor G allele of FOXO3 represses IL-10.", "The number of Ndc80 complexes varies with cell cycle timing.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "N348I mutations decrease resistance to zidovudine (AZT)."], "hard_negative": "All six cathelicidins are located on chromosome two."}
-{"query_id": "103", "query_text": "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "negative": "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "negatives": ["Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "Malaria has a low vectorial capacity.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer."], "hard_negatives": ["Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Distant CREs are more conserved among species.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "CENP-B inhibits heterochromatin formation", "Suboptimal nutrition is a leading cause of chronic disease", "All six cathelicidins are located on chromosome two.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Gene expression can be highly variable across genetically identical cells."], "hard_negative": "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico."}
-{"query_id": "107", "query_text": "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "negative": "Physical injury activates transgultaminase activity.", "negatives": ["Physical injury activates transgultaminase activity.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Obesity decreases life expectancy.", "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites."], "hard_negatives": ["Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Serotonin receptors have no effect on depression", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Serotonin receptors play a role in depression", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women."], "hard_negative": "Amitriptyline ineffective as a treatment for chronic tension-type headaches."}
-{"query_id": "110", "query_text": "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "negative": "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "negatives": ["Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "NLRP12 is a positive regulator of T-cell receptor activation.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine."], "hard_negatives": ["An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "N348I mutations decrease resistance to zidovudine (AZT).", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "The number of Ndc80 complexes varies with cell cycle timing.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df."], "hard_negative": "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove."}
-{"query_id": "117", "query_text": "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "negative": "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "negatives": ["Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Satellite cell dysfunction is not a key factor in sarcopenia development.", "Notch signalling can occur between tumor cells and stromal cells.", "Major vault protein (MVP) functions to decrease tumor aggression.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis."], "hard_negatives": ["Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "The innate immune response is efficient at removing small numbers of parasites.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "N348I mutations decrease resistance to zidovudine (AZT).", "AZT given with ribavirin alleviates anemia.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year."], "hard_negative": "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile"}
-{"query_id": "125", "query_text": "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "negative": "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "negatives": ["Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures."], "hard_negatives": ["Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells."], "hard_negative": "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."}
-{"query_id": "131", "query_text": "Aspirin encourages the production of PGE2.", "negative": "CRY proteins mediate light signal transduction.", "negatives": ["CRY proteins mediate light signal transduction.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Self-advocacy training is not effective at decreasing homelessness.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "Tet enzymes activate microRNAs required for iPSC derivation."], "hard_negatives": ["Aspirin encourages the production of PGE2.", "PEP carboxylase enhances threonine production in E. coli.", "PEP carboxylase suppresses threonine production in E. coli.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "High levels of copeptin increase risk of diabetes.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Higher initial mortality is associated with antidepressant use.", "Autophagy deficiency in the liver protects from insulin resistance."], "hard_negative": "Aspirin encourages the production of PGE2."}
-{"query_id": "135", "query_text": "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "negative": "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "negatives": ["Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "The minor G allele of FOXO3 represses IL-10.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "In the UK, drowning affects boys at a higher rate than girls.", "Suboptimal nutrition is a leading cause of chronic disease", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Physical activity levels have been associated with the differences in VO2max between black and white youth."], "hard_negatives": ["Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Vitamin D deficiency has no effect on the term of child delivery.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Low saturated fat diets have adverse effects on growth or development of infants.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Incidence rates of cervical cancer have increased over time.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa."], "hard_negative": "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight."}
-{"query_id": "136", "query_text": "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "negative": "Ginger is safe for mechanically ventilated patients.", "negatives": ["Ginger is safe for mechanically ventilated patients.", "High cardiopulmonary fitness causes decreased mortality rate.", "AZT given with ribavirin alleviates anemia.", "Self-advocacy training is not effective at decreasing homelessness.", "Rapamycin treatment raises G-CSF levels.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Tuberculosis incidence is correlated with residential crowding in the UK."], "hard_negatives": ["Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Vitamin D deficiency has no effect on the term of child delivery.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Hypoglycemia decreases the risk of dementia.", "Higher initial mortality is associated with antidepressant use.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age."], "hard_negative": "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight."}
-{"query_id": "140", "query_text": "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "negative": "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "negatives": ["Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "CHEK2 has a significant role in breast cancer", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Obesity prolongs life expectancy.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals."], "hard_negatives": ["Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Obesity is determined in part by genetic factors.", "Hypoglycemia decreases the risk of dementia.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "There are four spatial channels in each hemifield of the auditory cortex of cats."], "hard_negative": "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls."}
-{"query_id": "145", "query_text": "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "negative": "Incidence of sepsis has remained stable between 2009-2014.", "negatives": ["Incidence of sepsis has remained stable between 2009-2014.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Higher initial mortality is associated with antidepressant use.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries."], "hard_negatives": ["Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome."], "hard_negative": "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies."}
-{"query_id": "147", "query_text": "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "negative": "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "negatives": ["Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "Foxp3 displaces Foxo1 on chromatin", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "Aspirin encourages the production of PGE2.", "Bariatric surgery reduces resolution of diabetes.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Satellite cell dysfunction is not a key factor in sarcopenia development.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy."], "hard_negatives": ["Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Metastases have genomic aberrations different than those of the primary tumor.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation."], "hard_negative": "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies."}
-{"query_id": "150", "query_text": "Autophagy deficiency in the liver protects from insulin resistance.", "negative": "PEP carboxylase suppresses threonine production in E. coli.", "negatives": ["PEP carboxylase suppresses threonine production in E. coli.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Obesity decreases life expectancy.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."], "hard_negatives": ["Autophagy deficiency in the liver protects from insulin resistance.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "A deficiency of folate decreases blood levels of homocysteine.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "High levels of copeptin increase risk of diabetes.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Increased calcium levels activate transgultaminase activity.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Bariatric surgery reduces resolution of diabetes."], "hard_negative": "Autophagy deficiency in the liver protects from insulin resistance."}
-{"query_id": "151", "query_text": "Autophagy increases in aged organisms.", "negative": "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "negatives": ["The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Rapamycin treatment raises G-CSF levels.", "Persister cells lead to clinical relapse in cancer patients.", "NLRP12 is a positive regulator of T-cell receptor activation.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics."], "hard_negatives": ["Autophagy increases in aged organisms.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Cellular aging is uncorrelated with an older appearance.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Autophagy deficiency in the liver protects from insulin resistance.", "Hypoglycemia decreases the risk of dementia.", "Obesity decreases life expectancy."], "hard_negative": "Autophagy increases in aged organisms."}
-{"query_id": "158", "query_text": "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "negative": "During the primary early antibody response activated B cells express low levels of EBI2.", "negatives": ["During the primary early antibody response activated B cells express low levels of EBI2.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Bronchial responsiveness is higher in the summer than in the winter.", "Suboptimal nutrition is a leading cause of chronic disease", "Choice of specialty is not influenced by debt accrued from medical training.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions."], "hard_negatives": ["BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "CHEK2 has a significant role in breast cancer", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species."], "hard_negative": "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation."}
-{"query_id": "162", "query_text": "Bariatric surgery has a deleterious impact on mental health.", "negative": "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "negatives": ["Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Obesity prolongs life expectancy.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "All phenotypes associated with reduced IIS require the gene daf-16.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Short British students are bullied less than control British students.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "G-CSF prevents MDSCs from infiltrating tumors."], "hard_negatives": ["Bariatric surgery has a deleterious impact on mental health.", "Bariatric surgery reduces resolution of diabetes.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Teaching hospitals provide better care than non-teaching hospitals.", "Hypoglycemia decreases the risk of dementia.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "There is no relation between lupus erythematosus and cardiovascular disease", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Suboptimal nutrition is a leading cause of chronic disease"], "hard_negative": "Bariatric surgery has a deleterious impact on mental health."}
-{"query_id": "170", "query_text": "Bariatric surgery reduces resolution of diabetes.", "negative": "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "negatives": ["Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Hypoglycemia decreases the risk of dementia.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Notch signalling can occur between tumor cells and stromal cells."], "hard_negatives": ["Bariatric surgery reduces resolution of diabetes.", "Bariatric surgery has a deleterious impact on mental health.", "Autophagy deficiency in the liver protects from insulin resistance.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "AZT given with ribavirin alleviates anemia.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Hypoglycemia decreases the risk of dementia."], "hard_negative": "Bariatric surgery reduces resolution of diabetes."}
-{"query_id": "188", "query_text": "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "negative": "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "negatives": ["Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Obesity prolongs life expectancy.", "Increased calcium levels repress transgultaminase activity.", "Excess nitric oxide is responsible for vasospasm.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "IL-10 production by monocytes encourages CD4 + T cell response.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration."], "hard_negatives": ["Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "During the primary early antibody response activated B cells express high levels of EBI2.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue."], "hard_negative": "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids."}
-{"query_id": "190", "query_text": "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "negative": "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "negatives": ["Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Teaching hospitals provide better care than non-teaching hospitals.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Major vault protein (MVP) functions to decrease tumor aggression.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "Short British students are bullied less than control British students.", "Satellite cell dysfunction is not a key factor in sarcopenia development.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Colloid exposure has no effect on morbidity."], "hard_negatives": ["Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The innate immune response is efficient at removing small numbers of parasites.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue."], "hard_negative": "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites."}
-{"query_id": "191", "query_text": "Bronchial responsiveness is higher in the summer than in the winter.", "negative": "Foxp3 displaces Foxo1 on chromatin", "negatives": ["Foxp3 displaces Foxo1 on chromatin", "Cellular aging is uncorrelated with an older appearance.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "A deficiency of folate decreases blood levels of homocysteine.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites."], "hard_negatives": ["Bronchial responsiveness is higher in the summer than in the winter.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "High levels of copeptin increase risk of diabetes.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy."], "hard_negative": "Bronchial responsiveness is higher in the summer than in the winter."}
-{"query_id": "192", "query_text": "Bronchial responsiveness is the same in the winter and summer seasons.", "negative": "Increased calcium levels activate transgultaminase activity.", "negatives": ["Increased calcium levels activate transgultaminase activity.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "RUNX is a top ranscription factor in skin tissue.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "The PDPN gene activates the C-type lectin receptor (CLEC-2)."], "hard_negatives": ["Bronchial responsiveness is the same in the winter and summer seasons.", "Bronchial responsiveness is higher in the summer than in the winter.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Ginger is safe for mechanically ventilated patients.", "Gastric lavage shows no benefit for acute paraquat poisoning."], "hard_negative": "Bronchial responsiveness is the same in the winter and summer seasons."}
-{"query_id": "193", "query_text": "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "negative": "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "negatives": ["Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "Pyridostatin delays checkpoint activation.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Choice of specialty is not influenced by debt accrued from medical training.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA."], "hard_negatives": ["C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Mitochondria play a major role in calcium homeostasis.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase."], "hard_negative": "C-Met is involved in epithelial-mesenchymal transition in tumor cells."}
-{"query_id": "194", "query_text": "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "negative": "LRBA controls CTLA - 4 expression.", "negatives": ["LRBA controls CTLA - 4 expression.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Lithium damages function in the SCA1 mouse model", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Increased calcium levels repress transgultaminase activity."], "hard_negatives": ["C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes."], "hard_negative": "C. elegans germlines lose their immortal character when nuclear RNAi is activated."}
-{"query_id": "195", "query_text": "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "negative": "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "negatives": ["Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Lithium damages function in the SCA1 mouse model", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Some countries have achieved the goal of eradicting malaria."], "hard_negatives": ["C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes."], "hard_negative": "C. elegans germlines lose their immortal character when nuclear RNAi is disabled."}
-{"query_id": "202", "query_text": "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "negative": "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "negatives": ["Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "High cardiopulmonary fitness causes decreased mortality rate.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Having a main partner increases survival rates in HIV patients.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Bronchial responsiveness is the same in the winter and summer seasons.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."], "hard_negatives": ["CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "p16INK4A accumulation is encoded by CDKN2A.", "CHEK2 has a significant role in breast cancer", "DUSP4 downregulation activates the Ras-ERK pathway", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors."], "hard_negative": "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis."}
-{"query_id": "206", "query_text": "CENP-B inhibits heterochromatin formation", "negative": "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "negatives": ["c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "Sustained transmission of Avian influenza A between humans is not observed.", "Short British students are bullied less than control British students.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis"], "hard_negatives": ["CENP-B inhibits heterochromatin formation", "Foxp3 displaces Foxo1 on chromatin", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "p16INK4A accumulation is encoded by CDKN2A.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "LRBA controls CTLA - 4 expression.", "During the primary early antibody response activated B cells express high levels of EBI2.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "During the primary early antibody response activated B cells express low levels of EBI2."], "hard_negative": "CENP-B inhibits heterochromatin formation"}
-{"query_id": "207", "query_text": "CHEK2 has a significant role in breast cancer", "negative": "Side effects associated with antidepressants decrease risk of stroke.", "negatives": ["Side effects associated with antidepressants decrease risk of stroke.", "Gene expression can be highly variable across genetically identical cells.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "PEP carboxylase suppresses threonine production in E. coli.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers."], "hard_negatives": ["CHEK2 has a significant role in breast cancer", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "NR5A2 is important in bile acid homeostasis in humans.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Foxp3 displaces Foxo1 on chromatin", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "DUSP4 downregulation activates the Ras-ERK pathway"], "hard_negative": "CHEK2 has a significant role in breast cancer"}
-{"query_id": "215", "query_text": "CRY proteins mediate light signal transduction.", "negative": "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "negatives": ["Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year."], "hard_negatives": ["CRY proteins mediate light signal transduction.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Mitochondria are uninvolved in processes related to cell signaling.", "Myelin sheaths play an important role in trophic support.", "Notch signalling can occur between tumor cells and stromal cells.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Mitochondria play a major role in calcium homeostasis.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1."], "hard_negative": "CRY proteins mediate light signal transduction."}
-{"query_id": "231", "query_text": "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "negative": "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "negatives": ["The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Bariatric surgery reduces resolution of diabetes.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "DUSP4 downregulation activates the Ras-ERK pathway", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels."], "hard_negatives": ["Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "A deficiency of folate decreases blood levels of homocysteine.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Hypoglycemia decreases the risk of dementia.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Side effects associated with antidepressants increases risk of myocardial infarction."], "hard_negative": "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries."}
-{"query_id": "234", "query_text": "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "negative": "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "negatives": ["The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Mitochondria play a major role in calcium homeostasis.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Pyridostatin delays checkpoint activation.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "Low saturated fat diets have adverse effects on growth or development of infants.", "AZT given with ribavirin alleviates anemia.", "All phenotypes associated with reduced IIS require the gene daf-16.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Self-advocacy training is not effective at decreasing homelessness."], "hard_negatives": ["Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Gene expression can be highly variable across genetically identical cells.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Mitochondria are uninvolved in processes related to cell signaling.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled."], "hard_negative": "Cell autonomous sex determination in somatic cells does not occur in Passeriformes."}
-{"query_id": "240", "query_text": "Cellular aging is uncorrelated with an older appearance.", "negative": "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "negatives": ["V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "CHEK2 has a significant role in breast cancer", "Rapamycin treatment raises G-CSF levels.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "During the primary early antibody response activated B cells express high levels of EBI2."], "hard_negatives": ["Cellular aging is uncorrelated with an older appearance.", "Autophagy increases in aged organisms.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Obesity is determined in part by genetic factors.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy."], "hard_negative": "Cellular aging is uncorrelated with an older appearance."}
-{"query_id": "252", "query_text": "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "negative": "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "negatives": ["The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Participating in six months of physical activity impairs cognitive functioning.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Serotonin receptors play a role in depression", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation."], "hard_negatives": ["Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Malaria has a low vectorial capacity.", "The innate immune response is efficient at removing small numbers of parasites.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Sustained transmission of Avian influenza A between humans is not observed.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Some countries have achieved the goal of eradicting malaria.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls."], "hard_negative": "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice."}
-{"query_id": "257", "query_text": "Choice of specialty is not influenced by debt accrued from medical training.", "negative": "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "negatives": ["De novo assembly of sequence data has longer contigs than unassembled sequence data.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Increased calcium levels repress transgultaminase activity.", "Vitamin D deficiency has no effect on the term of child delivery.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Increased calcium levels repress transgultaminase activity.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Aspirin encourages the production of PGE2."], "hard_negatives": ["Choice of specialty is not influenced by debt accrued from medical training.", "Teaching hospitals provide better care than non-teaching hospitals.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Bariatric surgery has a deleterious impact on mental health.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Bariatric surgery reduces resolution of diabetes.", "There is no relation between lupus erythematosus and cardiovascular disease", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics."], "hard_negative": "Choice of specialty is not influenced by debt accrued from medical training."}
-{"query_id": "260", "query_text": "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "negative": "Choice of specialty is not influenced by debt accrued from medical training.", "negatives": ["Choice of specialty is not influenced by debt accrued from medical training.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "All six cathelicidins are located on chromosome two.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Serotonin receptors play a role in depression", "Major vault protein (MVP) functions to decrease tumor aggression.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine."], "hard_negatives": ["Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "Excess nitric oxide is responsible for vasospasm.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Autophagy deficiency in the liver protects from insulin resistance.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway."], "hard_negative": "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO."}
-{"query_id": "270", "query_text": "Colloid exposure causes morbidity.", "negative": "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "negatives": ["PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Obesity is determined in part by genetic factors.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Obesity prolongs life expectancy.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Excess nitric oxide is responsible for vasospasm."], "hard_negatives": ["Colloid exposure causes morbidity.", "Colloid exposure has no effect on morbidity.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "A deficiency of folate decreases blood levels of homocysteine.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Hypoglycemia decreases the risk of dementia.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight."], "hard_negative": "Colloid exposure causes morbidity."}
-{"query_id": "271", "query_text": "Colloid exposure has no effect on morbidity.", "negative": "N348I mutations decrease resistance to zidovudine (AZT).", "negatives": ["N348I mutations decrease resistance to zidovudine (AZT).", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Hypoglycemia decreases the risk of dementia.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Serotonin receptors play a role in depression", "Serotonin receptors play a role in depression", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy."], "hard_negatives": ["Colloid exposure has no effect on morbidity.", "Colloid exposure causes morbidity.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Sustained transmission of Avian influenza A between humans is not observed.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "A deficiency of folate decreases blood levels of homocysteine.", "Hypoglycemia decreases the risk of dementia."], "hard_negative": "Colloid exposure has no effect on morbidity."}
-{"query_id": "273", "query_text": "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "negative": "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "negatives": ["Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "PEP carboxylase suppresses threonine production in E. coli.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Mitochondria are uninvolved in processes related to cell signaling.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."], "hard_negatives": ["Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants decrease risk of stroke.", "Higher initial mortality is associated with antidepressant use.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption."], "hard_negative": "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy."}
-{"query_id": "276", "query_text": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "negative": "The number of Ndc80 complexes varies with cell cycle timing.", "negatives": ["The number of Ndc80 complexes varies with cell cycle timing.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "The DESMOND program significantly improves biochemical outcomes.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Obesity decreases life expectancy.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "A deficiency of folate decreases blood levels of homocysteine."], "hard_negatives": ["Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "CHEK2 has a significant role in breast cancer", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Metastases have genomic aberrations different than those of the primary tumor.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df."], "hard_negative": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors."}
-{"query_id": "282", "query_text": "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "negative": "Increased calcium levels activate transgultaminase activity.", "negatives": ["Increased calcium levels activate transgultaminase activity.", "PEP carboxylase enhances threonine production in E. coli.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Malaria has a low vectorial capacity.", "All six cathelicidins are located on chromosome two.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "The minor G allele of FOXO3 represses IL-10.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "All six cathelicidins are located on chromosome two.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors."], "hard_negatives": ["Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "p16INK4A accumulation is encoded by CDKN2A.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "LSD1 plays a role in transcriptional activation", "The number of Ndc80 complexes varies with cell cycle timing.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation."], "hard_negative": "Conformational changes of the CD3 complex enable ITAM phosphorylation."}
-{"query_id": "284", "query_text": "Consumption of whole fruits reduces the risk of type 2 diabetes.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Having a main partner increases survival rates in HIV patients.", "Self-advocacy training is not effective at decreasing homelessness.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "Excess nitric oxide is responsible for vasospasm.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "AZT given with ribavirin alleviates anemia.", "The PDPN gene activates the C-type lectin receptor (CLEC-2)."], "hard_negatives": ["Consumption of whole fruits reduces the risk of type 2 diabetes.", "Autophagy deficiency in the liver protects from insulin resistance.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Bariatric surgery reduces resolution of diabetes.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Suboptimal nutrition is a leading cause of chronic disease", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year."], "hard_negative": "Consumption of whole fruits reduces the risk of type 2 diabetes."}
-{"query_id": "288", "query_text": "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "negative": "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "negatives": ["The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Incidence of sepsis has remained stable between 2009-2014.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Choice of specialty is not influenced by debt accrued from medical training.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Colloid exposure causes morbidity.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Bariatric surgery has a deleterious impact on mental health.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals."], "hard_negatives": ["Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "The number of Ndc80 complexes varies with cell cycle timing.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Genome size differences in rice are explained by LTR retrotransposon expansion."], "hard_negative": "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition."}
-{"query_id": "289", "query_text": "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "negative": "AZT given with ribavirin alleviates anemia.", "negatives": ["AZT given with ribavirin alleviates anemia.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Some countries have achieved the goal of eradicting malaria.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight."], "hard_negatives": ["Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "CRY proteins mediate light signal transduction.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "De novo assembly of sequence data has longer contigs than unassembled sequence data."], "hard_negative": "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques."}
-{"query_id": "291", "query_text": "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "negative": "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "negatives": ["Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation."], "hard_negatives": ["Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Teaching hospitals provide better care than non-teaching hospitals.", "Higher initial mortality is associated with antidepressant use.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Choice of specialty is not influenced by debt accrued from medical training.", "Participants who quit smoking reduce lung cancer risk by approximately 5%."], "hard_negative": "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice."}
-{"query_id": "297", "query_text": "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "negative": "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "negatives": ["The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis."], "hard_negatives": ["Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Mitochondria play a major role in calcium homeostasis.", "Mitochondria are uninvolved in processes related to cell signaling.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Foxp3 displaces Foxo1 on chromatin"], "hard_negative": "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis."}
-{"query_id": "302", "query_text": "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "negative": "Participating in six months of physical activity impairs cognitive functioning.", "negatives": ["Participating in six months of physical activity impairs cognitive functioning.", "Major vault protein (MVP) functions to decrease tumor aggression.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Notch signalling can occur between tumor cells and stromal cells.", "Suboptimal nutrition is a leading cause of chronic disease", "Pyridostatin delays checkpoint activation.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "Self-advocacy training is not effective at decreasing homelessness."], "hard_negatives": ["Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Mitochondria play a major role in calcium homeostasis.", "A deficiency of folate decreases blood levels of homocysteine.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "NR5A2 is important in bile acid homeostasis in humans.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Osteocytes are not associated with G-CSF induced HSPC mobilization."], "hard_negative": "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1."}
-{"query_id": "307", "query_text": "DUSP4 downregulation activates the Ras-ERK pathway", "negative": "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "negatives": ["There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "p16INK4A accumulation is encoded by CDKN2A.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "The innate immune response is efficient at removing small numbers of parasites.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "During the primary early antibody response activated B cells express low levels of EBI2."], "hard_negatives": ["DUSP4 downregulation activates the Ras-ERK pathway", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."], "hard_negative": "DUSP4 downregulation activates the Ras-ERK pathway"}
-{"query_id": "311", "query_text": "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "negative": "Patients in stable partnerships have a slower progression from HIV to death.", "negatives": ["Patients in stable partnerships have a slower progression from HIV to death.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Some countries have achieved the goal of eradicting malaria.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues."], "hard_negatives": ["De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Gene expression can be highly variable across genetically identical cells.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques."], "hard_negative": "De novo assembly of sequence data has longer contigs than unassembled sequence data."}
-{"query_id": "318", "query_text": "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "negative": "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "negatives": ["MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "All phenotypes associated with reduced IIS require the gene daf-16.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Excess nitric oxide is responsible for vasospasm.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Serotonin receptors play a role in depression"], "hard_negatives": ["Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Autophagy increases in aged organisms.", "Autophagy deficiency in the liver protects from insulin resistance.", "Cellular aging is uncorrelated with an older appearance.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy."], "hard_negative": "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism."}
-{"query_id": "319", "query_text": "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "negative": "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "negatives": ["Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "IL-10 production by monocytes encourages CD4 + T cell response.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species."], "hard_negatives": ["Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Autophagy increases in aged organisms.", "Autophagy deficiency in the liver protects from insulin resistance.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Cellular aging is uncorrelated with an older appearance.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Hypoglycemia decreases the risk of dementia.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects."], "hard_negative": "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism."}
-{"query_id": "320", "query_text": "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "negative": "Pyridostatin delays checkpoint activation.", "negatives": ["Pyridostatin delays checkpoint activation.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "Serotonin receptors have no effect on depression", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation."], "hard_negatives": ["Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "N348I mutations decrease resistance to zidovudine (AZT).", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies."], "hard_negative": "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation."}
-{"query_id": "321", "query_text": "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "negative": "Serotonin receptors play a role in depression", "negatives": ["Serotonin receptors play a role in depression", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Ginger is safe for mechanically ventilated patients.", "High cardiopulmonary fitness causes decreased mortality rate.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile"], "hard_negatives": ["Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "N348I mutations decrease resistance to zidovudine (AZT).", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "A deficiency of folate decreases blood levels of homocysteine.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled."], "hard_negative": "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation."}
-{"query_id": "322", "query_text": "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "negative": "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "negatives": ["A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Obesity decreases life expectancy.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression."], "hard_negatives": ["Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Vitamin D deficiency has no effect on the term of child delivery.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "LSD1 plays a role in transcriptional activation"], "hard_negative": "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1."}
-{"query_id": "328", "query_text": "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "negative": "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "negatives": ["Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Bariatric surgery reduces resolution of diabetes.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "F4/80+ macrophages are located in the periosteum.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Incidence of sepsis has remained stable between 2009-2014.", "LRBA controls CTLA - 4 expression.", "Bronchial responsiveness is higher in the summer than in the winter."], "hard_negatives": ["Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "N348I mutations decrease resistance to zidovudine (AZT).", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "AZT given with ribavirin alleviates anemia.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "A deficiency of vitamin B6 increases blood levels of homocysteine."], "hard_negative": "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."}
-{"query_id": "329", "query_text": "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "negative": "F4/80+ macrophages are located in the periosteum.", "negatives": ["F4/80+ macrophages are located in the periosteum.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Vitamin D deficiency has no effect on the term of child delivery.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease."], "hard_negatives": ["Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "LSD1 plays a role in transcriptional activation", "NLRP12 is a positive regulator of T-cell receptor activation.", "DUSP4 downregulation activates the Ras-ERK pathway", "mTORC2 inhibits xCT antiporter through phosphorylation.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Notch signalling can occur between tumor cells and stromal cells.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Serotonin receptors play a role in depression", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP."], "hard_negative": "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process."}
-{"query_id": "344", "query_text": "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "negative": "F4/80+ macrophages are located in the periosteum.", "negatives": ["F4/80+ macrophages are located in the periosteum.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Lithium damages function in the SCA1 mouse model", "NAC encourages the generation of angiotensin-converting enzyme.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "All phenotypes associated with reduced IIS require the gene daf-16.", "Vitamin D deficiency has no effect on the term of child delivery.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome."], "hard_negatives": ["Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "PEP carboxylase suppresses threonine production in E. coli.", "PEP carboxylase enhances threonine production in E. coli.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "F4/80+ macrophages are located in the periosteum.", "Autophagy deficiency in the liver protects from insulin resistance.", "Aspirin encourages the production of PGE2."], "hard_negative": "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis."}
-{"query_id": "348", "query_text": "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "negative": "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "negatives": ["The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Distant CREs are more conserved among species.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "Vitamin D deficiency has no effect on the term of child delivery.", "Incidence of sepsis has remained stable between 2009-2014."], "hard_negatives": ["Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Vitamin D deficiency has no effect on the term of child delivery.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Patients in stable partnerships have a slower progression from HIV to death.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Colloid exposure has no effect on morbidity.", "Having a main partner lowers survival rates in HIV patients."], "hard_negative": "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population."}
-{"query_id": "353", "query_text": "Distant CREs are more conserved among species.", "negative": "G-CSF prevents MDSCs from infiltrating tumors.", "negatives": ["G-CSF prevents MDSCs from infiltrating tumors.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."], "hard_negatives": ["Distant CREs are more conserved among species.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Gene expression can be highly variable across genetically identical cells.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers."], "hard_negative": "Distant CREs are more conserved among species."}
-{"query_id": "359", "query_text": "During the primary early antibody response activated B cells express high levels of EBI2.", "negative": "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "negatives": ["Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "High cardiopulmonary fitness causes decreased mortality rate.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Higher initial mortality is associated with antidepressant use.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Aspirin encourages the production of PGE2.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "The minor G allele of FOXO3 represses IL-10.", "Mitochondria are uninvolved in processes related to cell signaling.", "G-CSF prevents MDSCs from infiltrating tumors."], "hard_negatives": ["During the primary early antibody response activated B cells express high levels of EBI2.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "IL-10 production by monocytes encourages CD4 + T cell response.", "The minor G allele of FOXO3 represses IL-10.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP."], "hard_negative": "During the primary early antibody response activated B cells express high levels of EBI2."}
-{"query_id": "360", "query_text": "During the primary early antibody response activated B cells express low levels of EBI2.", "negative": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "negatives": ["Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Choice of specialty is not influenced by debt accrued from medical training.", "Short British students are bullied more than control British students.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Foxp3 displaces Foxo1 on chromatin", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population."], "hard_negatives": ["During the primary early antibody response activated B cells express low levels of EBI2.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "IL-10 production by monocytes encourages CD4 + T cell response.", "The minor G allele of FOXO3 represses IL-10.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negative": "During the primary early antibody response activated B cells express low levels of EBI2."}
-{"query_id": "373", "query_text": "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "negative": "NLRP12 is a positive regulator of T-cell receptor activation.", "negatives": ["NLRP12 is a positive regulator of T-cell receptor activation.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Notch signalling can occur between tumor cells and stromal cells.", "NR5A2 is important in bile acid homeostasis in humans.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus."], "hard_negatives": ["Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls."], "hard_negative": "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances."}
-{"query_id": "374", "query_text": "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "negative": "AZT given with ribavirin alleviates anemia.", "negatives": ["AZT given with ribavirin alleviates anemia.", "Myelin sheaths play an important role in trophic support.", "RUNX is a top ranscription factor in skin tissue.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "p16INK4A accumulation is encoded by CDKN2A.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions."], "hard_negatives": ["Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain."], "hard_negative": "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis."}
-{"query_id": "387", "query_text": "Esrrb associates with BAF and Mbd3/NURD complexes.", "negative": "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "negatives": ["C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Serotonin receptors have no effect on depression", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Rapamycin accelerates aging in fruit flies.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight."], "hard_negatives": ["Esrrb associates with BAF and Mbd3/NURD complexes.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "During the primary early antibody response activated B cells express low levels of EBI2.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process."], "hard_negative": "Esrrb associates with BAF and Mbd3/NURD complexes."}
-{"query_id": "395", "query_text": "Excess nitric oxide is responsible for vasospasm.", "negative": "Metastases have genomic aberrations different than those of the primary tumor.", "negatives": ["Metastases have genomic aberrations different than those of the primary tumor.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Physical injury activates transgultaminase activity.", "CRY proteins mediate light signal transduction.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Choice of specialty is not influenced by debt accrued from medical training.", "Metastases have genomic aberrations different than those of the primary tumor.", "Participating in six months of physical activity impairs cognitive functioning.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile"], "hard_negatives": ["Excess nitric oxide is responsible for vasospasm.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Increased calcium levels activate transgultaminase activity.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Autophagy deficiency in the liver protects from insulin resistance.", "Increased calcium levels repress transgultaminase activity."], "hard_negative": "Excess nitric oxide is responsible for vasospasm."}
-{"query_id": "402", "query_text": "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "negative": "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "negatives": ["Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Autophagy deficiency in the liver protects from insulin resistance.", "Participating in six months of physical activity impairs cognitive functioning.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Major vault protein (MVP) functions to decrease tumor aggression.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis."], "hard_negatives": ["Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "p16INK4A accumulation is encoded by CDKN2A.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "IL-10 production by monocytes encourages CD4 + T cell response.", "During the primary early antibody response activated B cells express low levels of EBI2.", "During the primary early antibody response activated B cells express high levels of EBI2.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis."], "hard_negative": "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2."}
-{"query_id": "405", "query_text": "F4/80+ macrophages are located in the periosteum.", "negative": "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "negatives": ["No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Having a main partner lowers survival rates in HIV patients.", "Rapamycin treatment raises G-CSF levels.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Excess nitric oxide is responsible for vasospasm."], "hard_negatives": ["F4/80+ macrophages are located in the periosteum.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "The number of Ndc80 complexes varies with cell cycle timing.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex."], "hard_negative": "F4/80+ macrophages are located in the periosteum."}
-{"query_id": "408", "query_text": "Falsified artemisinin family drugs with no active ingredient are generally safe.", "negative": "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "negatives": ["Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Side effects associated with antidepressants decrease risk of stroke.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice."], "hard_negatives": ["Falsified artemisinin family drugs with no active ingredient are generally safe.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "N348I mutations decrease resistance to zidovudine (AZT).", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "AZT given with ribavirin alleviates anemia.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "All six cathelicidins are located on chromosome two."], "hard_negative": "Falsified artemisinin family drugs with no active ingredient are generally safe."}
-{"query_id": "409", "query_text": "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "negative": "All six cathelicidins are located on chromosome two.", "negatives": ["All six cathelicidins are located on chromosome two.", "F4/80+ macrophages are located in the periosteum.", "Participating in six months of physical activity impairs cognitive functioning.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Short British students are bullied more than control British students.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin."], "hard_negatives": ["Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "N348I mutations decrease resistance to zidovudine (AZT).", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "AZT given with ribavirin alleviates anemia.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches."], "hard_negative": "Falsified artemisinin family drugs with no active ingredient can be life-threatening."}
-{"query_id": "412", "query_text": "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "negative": "A deficiency of folate decreases blood levels of homocysteine.", "negatives": ["A deficiency of folate decreases blood levels of homocysteine.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "NR5A2 is important in bile acid homeostasis in humans.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "Colloid exposure causes morbidity.", "Gene expression can be highly variable across genetically identical cells.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins."], "hard_negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Hypoglycemia decreases the risk of dementia.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Obesity is determined in part by genetic factors."], "hard_negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease."}
-{"query_id": "419", "query_text": "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "negative": "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "negatives": ["Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "CENP-B inhibits heterochromatin formation", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Higher initial mortality is associated with antidepressant use.", "p16INK4A accumulation is encoded by CDKN2A."], "hard_negatives": ["Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "p16INK4A accumulation is encoded by CDKN2A.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "LSD1 plays a role in transcriptional activation", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface."], "hard_negative": "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels."}
-{"query_id": "424", "query_text": "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "negative": "Consumption of whole fruits reduces the risk of type 2 diabetes.", "negatives": ["Consumption of whole fruits reduces the risk of type 2 diabetes.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Myelin sheaths play an important role in trophic support.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Roughly 10% of women with chronic pelvic pain have no underlying pathology."], "hard_negatives": ["For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Vitamin D deficiency has no effect on the term of child delivery.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "In the UK, drowning affects boys at a higher rate than girls.", "Obesity is determined in part by genetic factors.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Low saturated fat diets do not have adverse effects on growth or development of infants."], "hard_negative": "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth."}
-{"query_id": "427", "query_text": "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "negative": "Malaria has a low vectorial capacity.", "negatives": ["Malaria has a low vectorial capacity.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Lithium damages function in the SCA1 mouse model", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "Colloid exposure has no effect on morbidity.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The DESMOND program achieved a significant impact on lifestyles outcomes.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "LRBA controls CTLA - 4 expression."], "hard_negatives": ["Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Foxp3 displaces Foxo1 on chromatin", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Mitochondria play a major role in calcium homeostasis.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Mitochondria are uninvolved in processes related to cell signaling.", "The minor G allele of FOXO3 represses IL-10."], "hard_negative": "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest."}
-{"query_id": "433", "query_text": "Foxp3 displaces Foxo1 on chromatin", "negative": "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "negatives": ["Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Mitochondria play a major role in calcium homeostasis.", "Pyridostatin delays checkpoint activation.", "F4/80+ macrophages are located in the periosteum.", "Short British students are bullied less than control British students.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."], "hard_negatives": ["Foxp3 displaces Foxo1 on chromatin", "The minor G allele of FOXO3 represses IL-10.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "CHEK2 has a significant role in breast cancer", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "CENP-B inhibits heterochromatin formation", "mTORC2 inhibits xCT antiporter through phosphorylation.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."], "hard_negative": "Foxp3 displaces Foxo1 on chromatin"}
-{"query_id": "438", "query_text": "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "negative": "Side effects associated with antidepressants increases risk of myocardial infarction.", "negatives": ["Side effects associated with antidepressants increases risk of myocardial infarction.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "The minor G allele of FOXO3 represses IL-10.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Bronchial responsiveness is the same in the winter and summer seasons.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."], "hard_negatives": ["Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Some countries have achieved the goal of eradicting malaria.", "Malaria has a low vectorial capacity.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Teaching hospitals provide better care than non-teaching hospitals.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Having a main partner lowers survival rates in HIV patients.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Suboptimal nutrition is a leading cause of chronic disease", "Patients in stable partnerships have a slower progression from HIV to death."], "hard_negative": "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources."}
-{"query_id": "442", "query_text": "G-CSF prevents MDSCs from infiltrating tumors.", "negative": "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "negatives": ["IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "AZT given with ribavirin alleviates anemia.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection."], "hard_negatives": ["G-CSF prevents MDSCs from infiltrating tumors.", "Rapamycin treatment raises G-CSF levels.", "LRBA controls CTLA - 4 expression.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids."], "hard_negative": "G-CSF prevents MDSCs from infiltrating tumors."}
-{"query_id": "446", "query_text": "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "negative": "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "negatives": ["Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Distant CREs are more conserved among species.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO."], "hard_negatives": ["GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Increased calcium levels activate transgultaminase activity.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "NR5A2 is important in bile acid homeostasis in humans.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis"], "hard_negative": "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation."}
-{"query_id": "450", "query_text": "Gastric lavage shows no benefit for acute paraquat poisoning.", "negative": "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "negatives": ["S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Incidence rates of cervical cancer have increased over time.", "Higher initial mortality is associated with antidepressant use.", "CENP-B inhibits heterochromatin formation", "Notch signalling can occur between tumor cells and stromal cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Vitamin D deficiency has no effect on the term of child delivery.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Autophagy increases in aged organisms.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption."], "hard_negatives": ["Gastric lavage shows no benefit for acute paraquat poisoning.", "Colloid exposure has no effect on morbidity.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Colloid exposure causes morbidity.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Side effects associated with antidepressants decrease risk of stroke.", "Higher initial mortality is associated with antidepressant use.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy."], "hard_negative": "Gastric lavage shows no benefit for acute paraquat poisoning."}
-{"query_id": "451", "query_text": "Gene expression can be highly variable across genetically identical cells.", "negative": "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "negatives": ["In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "In the UK, drowning affects boys at a higher rate than girls.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "All phenotypes associated with reduced IIS require the gene daf-16.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Incidence rates of cervical cancer have increased over time.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "High cardiopulmonary fitness causes decreased mortality rate."], "hard_negatives": ["Gene expression can be highly variable across genetically identical cells.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "The number of Ndc80 complexes varies with cell cycle timing.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA."], "hard_negative": "Gene expression can be highly variable across genetically identical cells."}
-{"query_id": "457", "query_text": "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "negative": "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "negatives": ["Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "CRY proteins mediate light signal transduction.", "Obesity decreases life expectancy.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Obesity prolongs life expectancy."], "hard_negatives": ["Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "p16INK4A accumulation is encoded by CDKN2A.", "All phenotypes associated with reduced IIS require the gene daf-16.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels."], "hard_negative": "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function."}
-{"query_id": "459", "query_text": "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "negative": "Genome size differences in rice are explained by LTR retrotransposon expansion.", "negatives": ["Genome size differences in rice are explained by LTR retrotransposon expansion.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Excess nitric oxide is responsible for vasospasm.", "Choice of specialty is not influenced by debt accrued from medical training.", "Autophagy deficiency in the liver protects from insulin resistance.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy."], "hard_negatives": ["Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Obesity is determined in part by genetic factors.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Autophagy deficiency in the liver protects from insulin resistance.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy."], "hard_negative": "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity."}
-{"query_id": "460", "query_text": "Genetic deletion of JAM-A decreases gut permeability.", "negative": "Risedronate reduces risk of vertebral and non-vertebral fractures.", "negatives": ["Risedronate reduces risk of vertebral and non-vertebral fractures.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Excess nitric oxide is responsible for vasospasm.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Increased calcium levels activate transgultaminase activity.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Monoclonal antibody targeting of N-cadherin promotes growth."], "hard_negatives": ["Genetic deletion of JAM-A decreases gut permeability.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "A deficiency of vitamin B6 increases blood levels of homocysteine."], "hard_negative": "Genetic deletion of JAM-A decreases gut permeability."}
-{"query_id": "462", "query_text": "Genome size differences in rice are explained by LTR retrotransposon expansion.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Risedronate reduces risk of vertebral and non-vertebral fractures."], "hard_negatives": ["Genome size differences in rice are explained by LTR retrotransposon expansion.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Gene expression can be highly variable across genetically identical cells.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species."], "hard_negative": "Genome size differences in rice are explained by LTR retrotransposon expansion."}
-{"query_id": "464", "query_text": "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "negative": "Having a main partner lowers survival rates in HIV patients.", "negatives": ["Having a main partner lowers survival rates in HIV patients.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Bariatric surgery reduces resolution of diabetes.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Major vault protein (MVP) functions to decrease tumor aggression.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Piezo1 channels are sensors for cell crowding in epithelial cells."], "hard_negatives": ["Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "A deficiency of folate decreases blood levels of homocysteine.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway."], "hard_negative": "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation."}
-{"query_id": "465", "query_text": "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "negative": "Self-advocacy training is not effective at decreasing homelessness.", "negatives": ["Self-advocacy training is not effective at decreasing homelessness.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "There is no relation between lupus erythematosus and cardiovascular disease", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Obesity is determined in part by genetic factors.", "Mitochondria play a major role in calcium homeostasis.", "Self-advocacy training is not effective at decreasing homelessness.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Short British students are bullied less than control British students."], "hard_negatives": ["Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "A deficiency of folate decreases blood levels of homocysteine."], "hard_negative": "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation."}
-{"query_id": "467", "query_text": "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Hypoglycemia decreases the risk of dementia.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Mitochondria are uninvolved in processes related to cell signaling.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice."], "hard_negatives": ["Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "Ginger is safe for mechanically ventilated patients.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Bronchial responsiveness is higher in the summer than in the winter.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Gastric lavage shows no benefit for acute paraquat poisoning."], "hard_negative": "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers."}
-{"query_id": "468", "query_text": "Ginger is safe for mechanically ventilated patients.", "negative": "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "negatives": ["Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "In the UK, drowning affects boys at a higher rate than girls.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Malaria has a low vectorial capacity."], "hard_negatives": ["Ginger is safe for mechanically ventilated patients.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "Bronchial responsiveness is higher in the summer than in the winter.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Bronchial responsiveness is the same in the winter and summer seasons.", "AZT given with ribavirin alleviates anemia.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Side effects associated with antidepressants decrease risk of stroke."], "hard_negative": "Ginger is safe for mechanically ventilated patients."}
-{"query_id": "471", "query_text": "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "negative": "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "High levels of copeptin increase risk of diabetes.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "RUNX is a top ranscription factor in skin tissue."], "hard_negatives": ["Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Autophagy increases in aged organisms.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Obesity prolongs life expectancy."], "hard_negative": "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae."}
-{"query_id": "476", "query_text": "Golli-deficient T-cells are dormant in initial clonal expansion.", "negative": "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "negatives": ["Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Colloid exposure causes morbidity.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "There is no relation between lupus erythematosus and cardiovascular disease", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year."], "hard_negatives": ["Golli-deficient T-cells are dormant in initial clonal expansion.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "NLRP12 is a positive regulator of T-cell receptor activation.", "Transplanted human glial cells are incapable of differentiation within the host animal."], "hard_negative": "Golli-deficient T-cells are dormant in initial clonal expansion."}
-{"query_id": "477", "query_text": "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "negative": "Suboptimal nutrition is a leading cause of chronic disease", "negatives": ["Suboptimal nutrition is a leading cause of chronic disease", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Sustained transmission of Avian influenza A between humans is not observed.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers."], "hard_negatives": ["Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "NLRP12 is a positive regulator of T-cell receptor activation."], "hard_negative": "Golli-deficient T-cells are hyper proliferative in initial clonal expansion."}
-{"query_id": "496", "query_text": "Having a main partner increases survival rates in HIV patients.", "negative": "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "negatives": ["Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "G-CSF prevents MDSCs from infiltrating tumors.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Colloid exposure causes morbidity.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia."], "hard_negatives": ["Having a main partner increases survival rates in HIV patients.", "Having a main partner lowers survival rates in HIV patients.", "Patients in stable partnerships have a slower progression from HIV to death.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Some countries have achieved the goal of eradicting malaria.", "Higher initial mortality is associated with antidepressant use.", "Malaria has a low vectorial capacity.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Self-advocacy training is not effective at decreasing homelessness."], "hard_negative": "Having a main partner increases survival rates in HIV patients."}
-{"query_id": "497", "query_text": "Having a main partner lowers survival rates in HIV patients.", "negative": "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "negatives": ["Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Foxp3 displaces Foxo1 on chromatin", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "CRY proteins mediate light signal transduction."], "hard_negatives": ["Having a main partner lowers survival rates in HIV patients.", "Having a main partner increases survival rates in HIV patients.", "Patients in stable partnerships have a slower progression from HIV to death.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Some countries have achieved the goal of eradicting malaria.", "Higher initial mortality is associated with antidepressant use.", "Malaria has a low vectorial capacity.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negative": "Having a main partner lowers survival rates in HIV patients."}
-{"query_id": "503", "query_text": "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "negative": "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "negatives": ["The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Vitamin D deficiency has no effect on the term of child delivery.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Autophagy increases in aged organisms.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation."], "hard_negatives": ["Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Autophagy deficiency in the liver protects from insulin resistance.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Increased calcium levels activate transgultaminase activity."], "hard_negative": "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose."}
-{"query_id": "510", "query_text": "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "negative": "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "negatives": ["The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Obesity prolongs life expectancy.", "Obesity is determined in part by genetic factors.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Physical injury activates transgultaminase activity.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Bariatric surgery reduces resolution of diabetes.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia."], "hard_negatives": ["Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Patients in stable partnerships have a slower progression from HIV to death.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "IL-10 production by monocytes encourages CD4 + T cell response.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Malaria has a low vectorial capacity.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."], "hard_negative": "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."}
-{"query_id": "511", "query_text": "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "negative": "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "negatives": ["Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "There is no relation between lupus erythematosus and cardiovascular disease", "LSD1 plays a role in transcriptional activation", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "CHEK2 has a significant role in breast cancer", "Having a main partner increases survival rates in HIV patients.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A."], "hard_negatives": ["Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Patients in stable partnerships have a slower progression from HIV to death.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "IL-10 production by monocytes encourages CD4 + T cell response.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Malaria has a low vectorial capacity.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."], "hard_negative": "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."}
-{"query_id": "512", "query_text": "High cardiopulmonary fitness causes decreased mortality rate.", "negative": "Mitochondria play a major role in calcium homeostasis.", "negatives": ["Mitochondria play a major role in calcium homeostasis.", "Short British students are bullied more than control British students.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Bariatric surgery has a deleterious impact on mental health.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "The DESMOND program achieved a significant impact on lifestyles outcomes.", "Tuberculosis incidence is correlated with residential crowding in the UK."], "hard_negatives": ["High cardiopulmonary fitness causes decreased mortality rate.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Higher initial mortality is associated with antidepressant use.", "Hypoglycemia decreases the risk of dementia.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "There is no relation between lupus erythematosus and cardiovascular disease", "Suboptimal nutrition is a leading cause of chronic disease"], "hard_negative": "High cardiopulmonary fitness causes decreased mortality rate."}
-{"query_id": "518", "query_text": "High levels of copeptin increase risk of diabetes.", "negative": "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "negatives": ["c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Hypoglycemia decreases the risk of dementia.", "Serotonin receptors have no effect on depression", "Obesity decreases life expectancy.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Obesity decreases life expectancy."], "hard_negatives": ["High levels of copeptin increase risk of diabetes.", "Side effects associated with antidepressants decrease risk of stroke.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Autophagy deficiency in the liver protects from insulin resistance.", "Higher initial mortality is associated with antidepressant use.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "A deficiency of folate decreases blood levels of homocysteine.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year."], "hard_negative": "High levels of copeptin increase risk of diabetes."}
-{"query_id": "519", "query_text": "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "negative": "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "negatives": ["Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "Persister cells lead to clinical relapse in cancer patients.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats."], "hard_negatives": ["High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Gene expression can be highly variable across genetically identical cells.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation."], "hard_negative": "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species."}
-{"query_id": "520", "query_text": "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "negative": "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "negatives": ["Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Rapamycin treatment raises G-CSF levels.", "All six cathelicidins are located on chromosome two.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Pyridostatin delays checkpoint activation.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated."], "hard_negatives": ["High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Gene expression can be highly variable across genetically identical cells.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death."], "hard_negative": "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species."}
-{"query_id": "522", "query_text": "Higher initial mortality is associated with antidepressant use.", "negative": "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "negatives": ["Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "IL-10 production by monocytes encourages CD4 + T cell response.", "DUSP4 downregulation activates the Ras-ERK pathway", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "LRBA controls CTLA - 4 expression.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "\u03b21/Ketel is unable to bind microtubules."], "hard_negatives": ["Higher initial mortality is associated with antidepressant use.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy."], "hard_negative": "Higher initial mortality is associated with antidepressant use."}
-{"query_id": "534", "query_text": "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "negative": "IL-10 production by monocytes encourages CD4 + T cell response.", "negatives": ["IL-10 production by monocytes encourages CD4 + T cell response.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Short British students are bullied less than control British students.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Ginger is safe for mechanically ventilated patients.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels."], "hard_negatives": ["Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Bariatric surgery reduces resolution of diabetes.", "Excess nitric oxide is responsible for vasospasm.", "High levels of copeptin increase risk of diabetes.", "Bronchial responsiveness is higher in the summer than in the winter.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Side effects associated with antidepressants decrease risk of stroke."], "hard_negative": "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring."}
-{"query_id": "538", "query_text": "Hypoglycemia decreases the risk of dementia.", "negative": "Serotonin receptors have no effect on depression", "negatives": ["Serotonin receptors have no effect on depression", "\u03b21/Ketel is unable to bind microtubules.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "Genetic deletion of JAM-A decreases gut permeability.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Colloid exposure has no effect on morbidity.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."], "hard_negatives": ["Hypoglycemia decreases the risk of dementia.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Side effects associated with antidepressants decrease risk of stroke.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Higher initial mortality is associated with antidepressant use.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls."], "hard_negative": "Hypoglycemia decreases the risk of dementia."}
-{"query_id": "543", "query_text": "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "negative": "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "negatives": ["Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Short British students are bullied less than control British students.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients."], "hard_negatives": ["IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "During the primary early antibody response activated B cells express high levels of EBI2.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "p16INK4A accumulation is encoded by CDKN2A.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "mTORC2 inhibits xCT antiporter through phosphorylation."], "hard_negative": "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP."}
-{"query_id": "546", "query_text": "IL-10 production by monocytes encourages CD4 + T cell response.", "negative": "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "negatives": ["De novo assembly of sequence data has longer contigs than unassembled sequence data.", "NAC encourages the generation of angiotensin-converting enzyme.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "Participating in six months of physical activity impairs cognitive functioning.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Colloid exposure causes morbidity.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body."], "hard_negatives": ["IL-10 production by monocytes encourages CD4 + T cell response.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "The minor G allele of FOXO3 represses IL-10.", "NLRP12 is a positive regulator of T-cell receptor activation.", "During the primary early antibody response activated B cells express high levels of EBI2.", "During the primary early antibody response activated B cells express low levels of EBI2.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion."], "hard_negative": "IL-10 production by monocytes encourages CD4 + T cell response."}
-{"query_id": "556", "query_text": "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "negative": "A deficiency of folate decreases blood levels of homocysteine.", "negatives": ["A deficiency of folate decreases blood levels of homocysteine.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Obesity prolongs life expectancy.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Major vault protein (MVP) functions to decrease tumor aggression.", "Short British students are bullied less than control British students.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events"], "hard_negatives": ["Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Mitochondria are uninvolved in processes related to cell signaling.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response."], "hard_negative": "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA."}
-{"query_id": "558", "query_text": "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "negative": "Incidence rates of cervical cancer have increased over time.", "negatives": ["Incidence rates of cervical cancer have increased over time.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Major vault protein (MVP) functions to decrease tumor aggression.", "Short British students are bullied more than control British students.", "Colloid exposure causes morbidity.", "Genetic deletion of JAM-A decreases gut permeability.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "All phenotypes associated with reduced IIS require the gene daf-16."], "hard_negatives": ["Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Mitochondria are uninvolved in processes related to cell signaling.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "CENP-B inhibits heterochromatin formation", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Pyridostatin delays checkpoint activation.", "The innate immune response is efficient at removing small numbers of parasites."], "hard_negative": "Immune complex triggered cell death slows down extracellular release of nuclear DNA."}
-{"query_id": "561", "query_text": "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "negative": "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "negatives": ["The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "The number of Ndc80 complexes varies with cell cycle timing.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "During the primary early antibody response activated B cells express high levels of EBI2."], "hard_negatives": ["Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Mitochondria are uninvolved in processes related to cell signaling.", "Mitochondria play a major role in calcium homeostasis.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation."], "hard_negative": "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis"}
-{"query_id": "567", "query_text": "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "negative": "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "negatives": ["Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Having a main partner increases survival rates in HIV patients.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "DUSP4 downregulation activates the Ras-ERK pathway", "Genetic deletion of JAM-A decreases gut permeability.", "CENP-B inhibits heterochromatin formation", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Obesity decreases life expectancy."], "hard_negatives": ["In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Foxp3 displaces Foxo1 on chromatin", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex."], "hard_negative": "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells."}
-{"query_id": "581", "query_text": "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "negative": "Lithium damages function in the SCA1 mouse model", "negatives": ["Lithium damages function in the SCA1 mouse model", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Autophagy deficiency in the liver protects from insulin resistance.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity."], "hard_negatives": ["In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients."], "hard_negative": "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus."}
-{"query_id": "583", "query_text": "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "negative": "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "negatives": ["Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "DUSP4 downregulation activates the Ras-ERK pathway", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Incidence of sepsis has remained stable between 2009-2014.", "Obesity decreases life expectancy.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2."], "hard_negatives": ["In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Sustained transmission of Avian influenza A between humans is not observed.", "AZT given with ribavirin alleviates anemia.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year."], "hard_negative": "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus."}
-{"query_id": "586", "query_text": "In the UK, drowning affects boys at a higher rate than girls.", "negative": "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "negatives": ["Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Obesity decreases life expectancy.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Obesity prolongs life expectancy."], "hard_negatives": ["In the UK, drowning affects boys at a higher rate than girls.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Incidence rates of cervical cancer have increased over time.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Hypoglycemia decreases the risk of dementia."], "hard_negative": "In the UK, drowning affects boys at a higher rate than girls."}
-{"query_id": "596", "query_text": "Incidence of sepsis has remained stable between 2009-2014.", "negative": "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "negatives": ["The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Side effects associated with antidepressants decrease risk of stroke.", "Bariatric surgery has a deleterious impact on mental health.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Physical activity levels have been associated with the differences in VO2max between black and white youth."], "hard_negatives": ["Incidence of sepsis has remained stable between 2009-2014.", "Incidence rates of cervical cancer have increased over time.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Malaria has a low vectorial capacity.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Some countries have achieved the goal of eradicting malaria."], "hard_negative": "Incidence of sepsis has remained stable between 2009-2014."}
-{"query_id": "599", "query_text": "Incidence rates of cervical cancer have increased over time.", "negative": "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "negatives": ["Physical activity levels have been associated with the differences in VO2max between black and white youth.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Mitochondria are uninvolved in processes related to cell signaling.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Colloid exposure causes morbidity."], "hard_negatives": ["Incidence rates of cervical cancer have increased over time.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Incidence of sepsis has remained stable between 2009-2014.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Some countries have achieved the goal of eradicting malaria.", "In the UK, drowning affects boys at a higher rate than girls.", "Malaria has a low vectorial capacity.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer"], "hard_negative": "Incidence rates of cervical cancer have increased over time."}
-{"query_id": "604", "query_text": "Increased calcium levels activate transgultaminase activity.", "negative": "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "negatives": ["The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "All six cathelicidins are located on chromosome two.", "G-CSF prevents MDSCs from infiltrating tumors.", "High cardiopulmonary fitness causes decreased mortality rate.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries."], "hard_negatives": ["Increased calcium levels activate transgultaminase activity.", "Increased calcium levels repress transgultaminase activity.", "Physical injury activates transgultaminase activity.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Autophagy deficiency in the liver protects from insulin resistance.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Mitochondria play a major role in calcium homeostasis.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "A deficiency of folate decreases blood levels of homocysteine.", "Serotonin receptors play a role in depression"], "hard_negative": "Increased calcium levels activate transgultaminase activity."}
-{"query_id": "605", "query_text": "Increased calcium levels repress transgultaminase activity.", "negative": "There are four spatial channels in each hemifield of the auditory cortex of cats.", "negatives": ["There are four spatial channels in each hemifield of the auditory cortex of cats.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "LRBA controls CTLA - 4 expression.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile"], "hard_negatives": ["Increased calcium levels repress transgultaminase activity.", "Increased calcium levels activate transgultaminase activity.", "Physical injury activates transgultaminase activity.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Autophagy deficiency in the liver protects from insulin resistance.", "A deficiency of folate decreases blood levels of homocysteine.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "Mitochondria play a major role in calcium homeostasis."], "hard_negative": "Increased calcium levels repress transgultaminase activity."}
-{"query_id": "608", "query_text": "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "negative": "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "negatives": ["For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Obesity prolongs life expectancy.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Having a main partner increases survival rates in HIV patients.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Serotonin receptors play a role in depression", "The number of Ndc80 complexes varies with cell cycle timing."], "hard_negatives": ["Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "Metastases have genomic aberrations different than those of the primary tumor.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "CHEK2 has a significant role in breast cancer", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia."], "hard_negative": "Increased expression of Bcl2 is important for the maintenance and progression of tumors."}
-{"query_id": "627", "query_text": "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "negative": "DUSP4 downregulation activates the Ras-ERK pathway", "negatives": ["DUSP4 downregulation activates the Ras-ERK pathway", "Side effects associated with antidepressants decrease risk of stroke.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "DUSP4 downregulation activates the Ras-ERK pathway", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells."], "hard_negatives": ["Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis"], "hard_negative": "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria."}
-{"query_id": "629", "query_text": "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "negative": "The minor G allele of FOXO3 represses IL-10.", "negatives": ["The minor G allele of FOXO3 represses IL-10.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "High cardiopulmonary fitness causes decreased mortality rate.", "De novo assembly of sequence data has longer contigs than unassembled sequence data."], "hard_negatives": ["Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues."], "hard_negative": "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin."}
-{"query_id": "630", "query_text": "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "negative": "Teaching hospitals provide better care than non-teaching hospitals.", "negatives": ["Teaching hospitals provide better care than non-teaching hospitals.", "Short British students are bullied more than control British students.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration."], "hard_negatives": ["Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "The minor G allele of FOXO3 represses IL-10.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negative": "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors."}
-{"query_id": "634", "query_text": "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population."], "hard_negatives": ["Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Increased calcium levels activate transgultaminase activity.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Increased calcium levels repress transgultaminase activity.", "DUSP4 downregulation activates the Ras-ERK pathway", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation."], "hard_negative": "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling."}
-{"query_id": "639", "query_text": "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "negative": "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "negatives": ["Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "A deficiency of folate decreases blood levels of homocysteine.", "AZT given with ribavirin alleviates anemia.", "N348I mutations decrease resistance to zidovudine (AZT).", "There is no relation between lupus erythematosus and cardiovascular disease", "Esrrb associates with BAF and Mbd3/NURD complexes.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Sustained transmission of Avian influenza A between humans is not observed.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes."], "hard_negatives": ["Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "The innate immune response is efficient at removing small numbers of parasites.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis."], "hard_negative": "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance."}
-{"query_id": "656", "query_text": "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "negative": "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "negatives": ["The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Vitamin D deficiency has no effect on the term of child delivery.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Obesity decreases life expectancy.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year."], "hard_negatives": ["Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Myelin sheaths play an important role in trophic support.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses."], "hard_negative": "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation."}
-{"query_id": "664", "query_text": "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "negative": "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "negatives": ["Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "p16INK4A accumulation is encoded by CDKN2A.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "The innate immune response is efficient at removing small numbers of parasites."], "hard_negatives": ["KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "G-CSF prevents MDSCs from infiltrating tumors.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "LRBA controls CTLA - 4 expression.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia."], "hard_negative": "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions."}
-{"query_id": "675", "query_text": "LRBA controls CTLA - 4 expression.", "negative": "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "negatives": ["GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "NR5A2 is important in bile acid homeostasis in humans.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Notch signalling can occur between tumor cells and stromal cells.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis."], "hard_negatives": ["LRBA controls CTLA - 4 expression.", "G-CSF prevents MDSCs from infiltrating tumors.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "DUSP4 downregulation activates the Ras-ERK pathway", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "CENP-B inhibits heterochromatin formation", "Esrrb associates with BAF and Mbd3/NURD complexes."], "hard_negative": "LRBA controls CTLA - 4 expression."}
-{"query_id": "678", "query_text": "LSD1 plays a role in transcriptional activation", "negative": "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "negatives": ["Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "NR5A2 is important in bile acid homeostasis in humans.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls."], "hard_negatives": ["LSD1 plays a role in transcriptional activation", "Serotonin receptors play a role in depression", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Serotonin receptors have no effect on depression", "NLRP12 is a positive regulator of T-cell receptor activation.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "The PDPN gene activates the C-type lectin receptor (CLEC-2)."], "hard_negative": "LSD1 plays a role in transcriptional activation"}
-{"query_id": "695", "query_text": "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "negative": "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "negatives": ["Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "High cardiopulmonary fitness causes decreased mortality rate.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "High cardiopulmonary fitness causes decreased mortality rate.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negatives": ["Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse."], "hard_negative": "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells."}
-{"query_id": "697", "query_text": "Lithium damages function in the SCA1 mouse model", "negative": "Golli-deficient T-cells are dormant in initial clonal expansion.", "negatives": ["Golli-deficient T-cells are dormant in initial clonal expansion.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation."], "hard_negatives": ["Lithium damages function in the SCA1 mouse model", "p16INK4A accumulation is encoded by CDKN2A.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "During the primary early antibody response activated B cells express low levels of EBI2.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df."], "hard_negative": "Lithium damages function in the SCA1 mouse model"}
-{"query_id": "699", "query_text": "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "negative": "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "negatives": ["Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Incidence rates of cervical cancer have increased over time.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "There is no relation between lupus erythematosus and cardiovascular disease", "Colloid exposure has no effect on morbidity."], "hard_negatives": ["Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "N348I mutations decrease resistance to zidovudine (AZT).", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Whole brain radiotherapy reduces the occurrence of new brain metastases."], "hard_negative": "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)."}
-{"query_id": "701", "query_text": "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "negative": "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "negatives": ["Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Low saturated fat diets have adverse effects on growth or development of infants.", "G-CSF prevents MDSCs from infiltrating tumors.", "A deficiency of folate decreases blood levels of homocysteine.", "Malaria has a low vectorial capacity.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia."], "hard_negatives": ["Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "LSD1 plays a role in transcriptional activation", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Foxp3 displaces Foxo1 on chromatin", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs)."], "hard_negative": "Localization of PIN1 in the Arabidopsis embryo requires VPS9a"}
-{"query_id": "706", "query_text": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "negative": "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "negatives": ["The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Colloid exposure causes morbidity.", "IL-10 production by monocytes encourages CD4 + T cell response.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Ginger is safe for mechanically ventilated patients.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Hypoglycemia decreases the risk of dementia.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Some signals for alternative polyadenylation sites are encoded in transposable elements."], "hard_negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Low saturated fat diets have adverse effects on growth or development of infants.", "High levels of copeptin increase risk of diabetes.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Autophagy deficiency in the liver protects from insulin resistance.", "AZT given with ribavirin alleviates anemia."], "hard_negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year."}
-{"query_id": "707", "query_text": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "negative": "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "negatives": ["Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "G-CSF prevents MDSCs from infiltrating tumors.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "N348I mutations decrease resistance to zidovudine (AZT)."], "hard_negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "High levels of copeptin increase risk of diabetes.", "Bariatric surgery reduces resolution of diabetes.", "PEP carboxylase enhances threonine production in E. coli.", "Consumption of whole fruits reduces the risk of type 2 diabetes."], "hard_negative": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year."}
-{"query_id": "708", "query_text": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "negative": "Serotonin receptors have no effect on depression", "negatives": ["Serotonin receptors have no effect on depression", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Rapamycin treatment raises G-CSF levels.", "Obesity decreases life expectancy.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Having a main partner increases survival rates in HIV patients.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Physical injury activates transgultaminase activity.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile"], "hard_negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Low saturated fat diets have adverse effects on growth or development of infants.", "High levels of copeptin increase risk of diabetes.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Autophagy deficiency in the liver protects from insulin resistance.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects."], "hard_negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year."}
-{"query_id": "711", "query_text": "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "The DESMOND program achieved a significant impact on lifestyles outcomes.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Vitamin D deficiency has no effect on the term of child delivery.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions."], "hard_negatives": ["Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "Higher initial mortality is associated with antidepressant use."], "hard_negative": "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy."}
-{"query_id": "712", "query_text": "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "negative": "All six cathelicidins are located on chromosome two.", "negatives": ["All six cathelicidins are located on chromosome two.", "\u03b21/Ketel is unable to bind microtubules.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "All phenotypes associated with reduced IIS require the gene daf-16.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "Malaria has a low vectorial capacity.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Teaching hospitals provide better care than non-teaching hospitals."], "hard_negatives": ["Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Higher initial mortality is associated with antidepressant use."], "hard_negative": "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy."}
-{"query_id": "719", "query_text": "Low saturated fat diets do not have adverse effects on growth or development of infants.", "negative": "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "negatives": ["Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Pyridostatin delays checkpoint activation.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Golli-deficient T-cells are dormant in initial clonal expansion."], "hard_negatives": ["Low saturated fat diets have adverse effects on growth or development of infants.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Obesity is determined in part by genetic factors.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "High levels of copeptin increase risk of diabetes.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Vitamin D deficiency has no effect on the term of child delivery."], "hard_negative": "Low saturated fat diets have adverse effects on growth or development of infants."}
-{"query_id": "720", "query_text": "Low saturated fat diets have adverse effects on growth or development of infants.", "negative": "Ginger is safe for mechanically ventilated patients.", "negatives": ["Ginger is safe for mechanically ventilated patients.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Lithium damages function in the SCA1 mouse model", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Bariatric surgery has a deleterious impact on mental health.", "Mitochondria are uninvolved in processes related to cell signaling."], "hard_negatives": ["Low saturated fat diets have adverse effects on growth or development of infants.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Obesity is determined in part by genetic factors.", "High levels of copeptin increase risk of diabetes.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year."], "hard_negative": "Low saturated fat diets have adverse effects on growth or development of infants."}
-{"query_id": "722", "query_text": "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "negative": "A deficiency of vitamin B6 increases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B6 increases blood levels of homocysteine.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "NLRP12 is a positive regulator of T-cell receptor activation.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption."], "hard_negatives": ["Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "There is no relation between lupus erythematosus and cardiovascular disease", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus."], "hard_negative": "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls."}
-{"query_id": "725", "query_text": "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "negative": "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "negatives": ["IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "Persister cells lead to clinical relapse in cancer patients.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Pyridostatin delays checkpoint activation.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis."], "hard_negatives": ["Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "LRBA controls CTLA - 4 expression.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "IL-10 production by monocytes encourages CD4 + T cell response.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "F4/80+ macrophages are located in the periosteum.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway."], "hard_negative": "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts."}
-{"query_id": "731", "query_text": "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "negative": "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "negatives": ["MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Mitochondria play a major role in calcium homeostasis.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface."], "hard_negatives": ["Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "N348I mutations decrease resistance to zidovudine (AZT).", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "PEP carboxylase suppresses threonine production in E. coli.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "p16INK4A accumulation is encoded by CDKN2A."], "hard_negative": "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A."}
-{"query_id": "735", "query_text": "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "negative": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "negatives": ["T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "LSD1 plays a role in transcriptional activation", "Participants who quit smoking reduce lung cancer risk by approximately 5%."], "hard_negatives": ["MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "CHEK2 has a significant role in breast cancer", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "DUSP4 downregulation activates the Ras-ERK pathway", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells."], "hard_negative": "MEK inhibitors are not effective in RAS-driven mouse models of cancer."}
-{"query_id": "741", "query_text": "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "negative": "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "negatives": ["The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Incidence of sepsis has remained stable between 2009-2014.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Notch signalling can occur between tumor cells and stromal cells.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Conformational changes of the CD3 complex enable ITAM phosphorylation."], "hard_negatives": ["MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "p16INK4A accumulation is encoded by CDKN2A.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "NR5A2 is important in bile acid homeostasis in humans.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function."], "hard_negative": "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df."}
-{"query_id": "750", "query_text": "Major vault protein (MVP) functions to decrease tumor aggression.", "negative": "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "negatives": ["Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "Pyridostatin delays checkpoint activation.", "The minor G allele of FOXO3 represses IL-10.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "LRBA controls CTLA - 4 expression.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Genetic deletion of JAM-A decreases gut permeability.", "Distant CREs are more conserved among species."], "hard_negatives": ["Major vault protein (MVP) functions to decrease tumor aggression.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Notch signalling can occur between tumor cells and stromal cells.", "G-CSF prevents MDSCs from infiltrating tumors.", "Satellite cell dysfunction is not a key factor in sarcopenia development.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "Metastases have genomic aberrations different than those of the primary tumor."], "hard_negative": "Major vault protein (MVP) functions to decrease tumor aggression."}
-{"query_id": "754", "query_text": "Malaria has a low vectorial capacity.", "negative": "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "negatives": ["Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Gene expression can be highly variable across genetically identical cells.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy."], "hard_negatives": ["Malaria has a low vectorial capacity.", "Some countries have achieved the goal of eradicting malaria.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The innate immune response is efficient at removing small numbers of parasites.", "Sustained transmission of Avian influenza A between humans is not observed.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Suboptimal nutrition is a leading cause of chronic disease"], "hard_negative": "Malaria has a low vectorial capacity."}
-{"query_id": "763", "query_text": "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "negative": "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "negatives": ["Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Aspirin encourages the production of PGE2.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Short British students are bullied more than control British students."], "hard_negatives": ["Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Incidence rates of cervical cancer have increased over time.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy."], "hard_negative": "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006."}
-{"query_id": "769", "query_text": "Metastases have genomic aberrations different than those of the primary tumor.", "negative": "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "negatives": ["Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Cellular aging is uncorrelated with an older appearance.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Colloid exposure has no effect on morbidity.", "Satellite cell dysfunction is not a key factor in sarcopenia development.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negatives": ["Metastases have genomic aberrations different than those of the primary tumor.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Hypoglycemia decreases the risk of dementia."], "hard_negative": "Metastases have genomic aberrations different than those of the primary tumor."}
-{"query_id": "773", "query_text": "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "negative": "mTORC2 inhibits xCT antiporter through phosphorylation.", "negatives": ["mTORC2 inhibits xCT antiporter through phosphorylation.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Foxp3 displaces Foxo1 on chromatin", "In the UK, drowning affects boys at a higher rate than girls.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "N348I mutations decrease resistance to zidovudine (AZT)."], "hard_negatives": ["Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Malaria has a low vectorial capacity.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "The innate immune response is efficient at removing small numbers of parasites.", "Sustained transmission of Avian influenza A between humans is not observed.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "Some countries have achieved the goal of eradicting malaria.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin."], "hard_negative": "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos."}
-{"query_id": "786", "query_text": "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "negative": "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "negatives": ["Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Myelin sheaths play an important role in trophic support.", "Pyridostatin delays checkpoint activation.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Metastases have genomic aberrations different than those of the primary tumor.", "Incidence rates of cervical cancer have increased over time.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species."], "hard_negatives": ["Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Gene expression can be highly variable across genetically identical cells.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques."], "hard_negative": "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures."}
-{"query_id": "794", "query_text": "Mitochondria are uninvolved in processes related to cell signaling.", "negative": "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "negatives": ["p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Side effects associated with antidepressants decrease risk of stroke.", "Rapamycin treatment raises G-CSF levels.", "The PDPN gene activates the C-type lectin receptor (CLEC-2)."], "hard_negatives": ["Mitochondria are uninvolved in processes related to cell signaling.", "Mitochondria play a major role in calcium homeostasis.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition."], "hard_negative": "Mitochondria are uninvolved in processes related to cell signaling."}
-{"query_id": "796", "query_text": "Mitochondria play a major role in calcium homeostasis.", "negative": "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "negatives": ["Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "\u03b21/Ketel is unable to bind microtubules.", "Bariatric surgery has a deleterious impact on mental health.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Obesity decreases life expectancy.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Tet enzymes activate microRNAs required for iPSC derivation."], "hard_negatives": ["Mitochondria play a major role in calcium homeostasis.", "Mitochondria are uninvolved in processes related to cell signaling.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Myelin sheaths play an important role in trophic support.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "Increased calcium levels activate transgultaminase activity.", "Adult tissue-resident macrophages possess a self-renewing capacity."], "hard_negative": "Mitochondria play a major role in calcium homeostasis."}
-{"query_id": "806", "query_text": "Monoclonal antibody targeting of N-cadherin promotes growth.", "negative": "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "negatives": ["Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "The innate immune response is efficient at removing small numbers of parasites.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Low saturated fat diets have adverse effects on growth or development of infants."], "hard_negatives": ["Monoclonal antibody targeting of N-cadherin promotes growth.", "N348I mutations decrease resistance to zidovudine (AZT).", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "During the primary early antibody response activated B cells express high levels of EBI2.", "During the primary early antibody response activated B cells express low levels of EBI2.", "G-CSF prevents MDSCs from infiltrating tumors.", "Rapamycin treatment raises G-CSF levels.", "Side effects associated with antidepressants decrease risk of stroke.", "AZT given with ribavirin alleviates anemia.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress."], "hard_negative": "Monoclonal antibody targeting of N-cadherin promotes growth."}
-{"query_id": "809", "query_text": "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "negative": "Colloid exposure has no effect on morbidity.", "negatives": ["Colloid exposure has no effect on morbidity.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "High levels of copeptin increase risk of diabetes.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function."], "hard_negatives": ["Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites."], "hard_negative": "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients."}
-{"query_id": "819", "query_text": "Myelin sheaths play an important role in trophic support.", "negative": "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "negatives": ["The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Bariatric surgery has a deleterious impact on mental health.", "Bariatric surgery has a deleterious impact on mental health.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose."], "hard_negatives": ["Myelin sheaths play an important role in trophic support.", "Mitochondria play a major role in calcium homeostasis.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Mitochondria are uninvolved in processes related to cell signaling.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation."], "hard_negative": "Myelin sheaths play an important role in trophic support."}
-{"query_id": "824", "query_text": "N348I mutations decrease resistance to zidovudine (AZT).", "negative": "PEP carboxylase suppresses threonine production in E. coli.", "negatives": ["PEP carboxylase suppresses threonine production in E. coli.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation."], "hard_negatives": ["N348I mutations decrease resistance to zidovudine (AZT).", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "The number of Ndc80 complexes varies with cell cycle timing.", "AZT given with ribavirin alleviates anemia.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "A deficiency of folate decreases blood levels of homocysteine.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia."], "hard_negative": "N348I mutations decrease resistance to zidovudine (AZT)."}
-{"query_id": "827", "query_text": "NAC encourages the generation of angiotensin-converting enzyme.", "negative": "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "negatives": ["The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Self-advocacy training is not effective at decreasing homelessness."], "hard_negatives": ["NAC encourages the generation of angiotensin-converting enzyme.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "NR5A2 is important in bile acid homeostasis in humans.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Increased calcium levels activate transgultaminase activity.", "Increased calcium levels repress transgultaminase activity.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy."], "hard_negative": "NAC encourages the generation of angiotensin-converting enzyme."}
-{"query_id": "829", "query_text": "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "NR5A2 is important in bile acid homeostasis in humans.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Increased calcium levels repress transgultaminase activity.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition."], "hard_negatives": ["NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "NR5A2 is important in bile acid homeostasis in humans.", "Excess nitric oxide is responsible for vasospasm.", "A deficiency of folate decreases blood levels of homocysteine.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "NAC encourages the generation of angiotensin-converting enzyme.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Side effects associated with antidepressants increases risk of myocardial infarction."], "hard_negative": "NAC stabilizes NO to reduce the effect of contrast agents on renal functions."}
-{"query_id": "833", "query_text": "NLRP12 is a positive regulator of T-cell receptor activation.", "negative": "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "negatives": ["The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Distant CREs are more conserved among species.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Metastases have genomic aberrations different than those of the primary tumor.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts."], "hard_negatives": ["NLRP12 is a positive regulator of T-cell receptor activation.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "LSD1 plays a role in transcriptional activation", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Serotonin receptors play a role in depression", "mTORC2 inhibits xCT antiporter through phosphorylation."], "hard_negative": "NLRP12 is a positive regulator of T-cell receptor activation."}
-{"query_id": "836", "query_text": "NR5A2 is important in bile acid homeostasis in humans.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Gene expression can be highly variable across genetically identical cells.", "Bronchial responsiveness is higher in the summer than in the winter.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "The minor G allele of FOXO3 represses IL-10."], "hard_negatives": ["NR5A2 is important in bile acid homeostasis in humans.", "p16INK4A accumulation is encoded by CDKN2A.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "A deficiency of folate decreases blood levels of homocysteine.", "CHEK2 has a significant role in breast cancer", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway."], "hard_negative": "NR5A2 is important in bile acid homeostasis in humans."}
-{"query_id": "842", "query_text": "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "negative": "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "p16INK4A accumulation is encoded by CDKN2A.", "Bariatric surgery has a deleterious impact on mental health.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Monoclonal antibody targeting of N-cadherin promotes growth."], "hard_negatives": ["Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat."], "hard_negative": "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy."}
-{"query_id": "843", "query_text": "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "negative": "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "negatives": ["Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "N348I mutations decrease resistance to zidovudine (AZT).", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells."], "hard_negatives": ["Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "CRY proteins mediate light signal transduction."], "hard_negative": "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy."}
-{"query_id": "849", "query_text": "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "negative": "Incidence rates of cervical cancer have increased over time.", "negatives": ["Incidence rates of cervical cancer have increased over time.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "LRBA controls CTLA - 4 expression.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Higher initial mortality is associated with antidepressant use.", "\u03b21/Ketel is unable to bind microtubules."], "hard_negatives": ["Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Obesity is determined in part by genetic factors.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Incidence rates of cervical cancer have increased over time.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer"], "hard_negative": "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight."}
-{"query_id": "850", "query_text": "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "negative": "PEP carboxylase enhances threonine production in E. coli.", "negatives": ["PEP carboxylase enhances threonine production in E. coli.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Distant CREs are more conserved among species.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis."], "hard_negatives": ["Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Excess nitric oxide is responsible for vasospasm.", "Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "NR5A2 is important in bile acid homeostasis in humans.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase."], "hard_negative": "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation."}
-{"query_id": "851", "query_text": "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Vitamin D deficiency has no effect on the term of child delivery.", "CENP-B inhibits heterochromatin formation", "Cellular aging is uncorrelated with an older appearance.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "PEP carboxylase enhances threonine production in E. coli."], "hard_negatives": ["No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Higher initial mortality is associated with antidepressant use.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer."], "hard_negative": "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer"}
-{"query_id": "862", "query_text": "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "negative": "Choice of specialty is not influenced by debt accrued from medical training.", "negatives": ["Choice of specialty is not influenced by debt accrued from medical training.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "LRBA controls CTLA - 4 expression.", "Excess nitric oxide is responsible for vasospasm.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "Persister cells lead to clinical relapse in cancer patients.", "LRBA controls CTLA - 4 expression.", "All phenotypes associated with reduced IIS require the gene daf-16.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negatives": ["Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "G-CSF prevents MDSCs from infiltrating tumors.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation."], "hard_negative": "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth."}
-{"query_id": "864", "query_text": "Notch signalling can occur between tumor cells and stromal cells.", "negative": "Pyridostatin delays checkpoint activation.", "negatives": ["Pyridostatin delays checkpoint activation.", "CHEK2 has a significant role in breast cancer", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Teaching hospitals provide better care than non-teaching hospitals.", "In the UK, drowning affects boys at a higher rate than girls.", "Ginger is safe for mechanically ventilated patients.", "Bronchial responsiveness is higher in the summer than in the winter.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated."], "hard_negatives": ["Notch signalling can occur between tumor cells and stromal cells.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "NLRP12 is a positive regulator of T-cell receptor activation.", "Mitochondria play a major role in calcium homeostasis.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway."], "hard_negative": "Notch signalling can occur between tumor cells and stromal cells."}
-{"query_id": "865", "query_text": "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "negative": "LSD1 plays a role in transcriptional activation", "negatives": ["LSD1 plays a role in transcriptional activation", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Rapamycin accelerates aging in fruit flies.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response."], "hard_negatives": ["Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "NR5A2 is important in bile acid homeostasis in humans.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "The number of Ndc80 complexes varies with cell cycle timing.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "All phenotypes associated with reduced IIS require the gene daf-16."], "hard_negative": "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus."}
-{"query_id": "868", "query_text": "Obesity decreases life expectancy.", "negative": "In the UK, drowning affects boys at a higher rate than girls.", "negatives": ["In the UK, drowning affects boys at a higher rate than girls.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "PEP carboxylase enhances threonine production in E. coli.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Colloid exposure causes morbidity.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "Cellular aging is uncorrelated with an older appearance."], "hard_negatives": ["Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Obesity is determined in part by genetic factors.", "High cardiopulmonary fitness causes decreased mortality rate.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Suboptimal nutrition is a leading cause of chronic disease", "Vitamin D deficiency has no effect on the term of child delivery."], "hard_negative": "Obesity decreases life expectancy."}
-{"query_id": "869", "query_text": "Obesity decreases life expectancy.", "negative": "Rapamycin accelerates aging in fruit flies.", "negatives": ["Rapamycin accelerates aging in fruit flies.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "All six cathelicidins are located on chromosome two.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Bariatric surgery reduces resolution of diabetes.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A."], "hard_negatives": ["Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Obesity is determined in part by genetic factors.", "High cardiopulmonary fitness causes decreased mortality rate.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Suboptimal nutrition is a leading cause of chronic disease", "Vitamin D deficiency has no effect on the term of child delivery."], "hard_negative": "Obesity decreases life expectancy."}
-{"query_id": "872", "query_text": "Obesity is determined in part by genetic factors.", "negative": "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "negatives": ["Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Excess nitric oxide is responsible for vasospasm.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Participating in six months of physical activity impairs cognitive functioning.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "RUNX is a top ranscription factor in skin tissue."], "hard_negatives": ["Obesity is determined in part by genetic factors.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Suboptimal nutrition is a leading cause of chronic disease"], "hard_negative": "Obesity is determined in part by genetic factors."}
-{"query_id": "874", "query_text": "Obesity prolongs life expectancy.", "negative": "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "negatives": ["The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "LSD1 plays a role in transcriptional activation", "PEP carboxylase enhances threonine production in E. coli.", "CRY proteins mediate light signal transduction.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects."], "hard_negatives": ["Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Obesity is determined in part by genetic factors.", "Low saturated fat diets have adverse effects on growth or development of infants.", "High cardiopulmonary fitness causes decreased mortality rate.", "Suboptimal nutrition is a leading cause of chronic disease", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Cellular aging is uncorrelated with an older appearance."], "hard_negative": "Obesity prolongs life expectancy."}
-{"query_id": "875", "query_text": "Obesity prolongs life expectancy.", "negative": "Esrrb associates with BAF and Mbd3/NURD complexes.", "negatives": ["Esrrb associates with BAF and Mbd3/NURD complexes.", "Obesity decreases life expectancy.", "Low saturated fat diets have adverse effects on growth or development of infants.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "CENP-B inhibits heterochromatin formation", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring."], "hard_negatives": ["Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Obesity is determined in part by genetic factors.", "Low saturated fat diets have adverse effects on growth or development of infants.", "High cardiopulmonary fitness causes decreased mortality rate.", "Suboptimal nutrition is a leading cause of chronic disease", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Cellular aging is uncorrelated with an older appearance."], "hard_negative": "Obesity prolongs life expectancy."}
-{"query_id": "878", "query_text": "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "negative": "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "negatives": ["Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs)."], "hard_negatives": ["Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients."], "hard_negative": "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain."}
-{"query_id": "888", "query_text": "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "negative": "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "negatives": ["Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "Self-advocacy training is not effective at decreasing homelessness.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "DUSP4 downregulation activates the Ras-ERK pathway", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "RUNX is a top ranscription factor in skin tissue."], "hard_negatives": ["Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants decrease risk of stroke.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "AZT given with ribavirin alleviates anemia.", "Higher initial mortality is associated with antidepressant use."], "hard_negative": "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women."}
-{"query_id": "889", "query_text": "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "negative": "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "negatives": ["Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hypoglycemia decreases the risk of dementia.", "Tet enzymes activate microRNAs required for iPSC derivation.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Colloid exposure causes morbidity.", "Satellite cell dysfunction is not a key factor in sarcopenia development."], "hard_negatives": ["Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants decrease risk of stroke.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "AZT given with ribavirin alleviates anemia.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy."], "hard_negative": "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women."}
-{"query_id": "892", "query_text": "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "negative": "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "negatives": ["25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "A deficiency of vitamin B6 increases blood levels of homocysteine."], "hard_negatives": ["Osteocytes are not associated with G-CSF induced HSPC mobilization.", "G-CSF prevents MDSCs from infiltrating tumors.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Increased calcium levels activate transgultaminase activity.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Rapamycin treatment raises G-CSF levels.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Mitochondria play a major role in calcium homeostasis.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Increased calcium levels repress transgultaminase activity."], "hard_negative": "Osteocytes are not associated with G-CSF induced HSPC mobilization."}
-{"query_id": "905", "query_text": "PEP carboxylase enhances threonine production in E. coli.", "negative": "A deficiency of vitamin B6 increases blood levels of homocysteine.", "negatives": ["A deficiency of vitamin B6 increases blood levels of homocysteine.", "Bariatric surgery has a deleterious impact on mental health.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Cellular aging is uncorrelated with an older appearance.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries."], "hard_negatives": ["PEP carboxylase enhances threonine production in E. coli.", "PEP carboxylase suppresses threonine production in E. coli.", "Aspirin encourages the production of PGE2.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "A deficiency of folate decreases blood levels of homocysteine.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year."], "hard_negative": "PEP carboxylase enhances threonine production in E. coli."}
-{"query_id": "906", "query_text": "PEP carboxylase suppresses threonine production in E. coli.", "negative": "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "negatives": ["Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Vitamin D deficiency has no effect on the term of child delivery.", "PEP carboxylase enhances threonine production in E. coli.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Obesity decreases life expectancy.", "Tet enzymes activate microRNAs required for iPSC derivation."], "hard_negatives": ["PEP carboxylase suppresses threonine production in E. coli.", "PEP carboxylase enhances threonine production in E. coli.", "Aspirin encourages the production of PGE2.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "A deficiency of folate decreases blood levels of homocysteine.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A."], "hard_negative": "PEP carboxylase suppresses threonine production in E. coli."}
-{"query_id": "915", "query_text": "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "negative": "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "negatives": ["S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Having a main partner increases survival rates in HIV patients.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Increased calcium levels activate transgultaminase activity.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice."], "hard_negatives": ["PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "CENP-B inhibits heterochromatin formation", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "\u03b21/Ketel is unable to bind microtubules.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes."], "hard_negative": "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients."}
-{"query_id": "918", "query_text": "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "negative": "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "negatives": ["Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "CRY proteins mediate light signal transduction.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection."], "hard_negatives": ["Participants who quit smoking reduce lung cancer risk by approximately 5%.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Higher initial mortality is associated with antidepressant use.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Incidence rates of cervical cancer have increased over time.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants decrease risk of stroke.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women."], "hard_negative": "Participants who quit smoking reduce lung cancer risk by approximately 5%."}
-{"query_id": "920", "query_text": "Participating in six months of physical activity impairs cognitive functioning.", "negative": "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "negatives": ["Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Metastases have genomic aberrations different than those of the primary tumor.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Bronchial responsiveness is higher in the summer than in the winter.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures."], "hard_negatives": ["Participating in six months of physical activity impairs cognitive functioning.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth."], "hard_negative": "Participating in six months of physical activity impairs cognitive functioning."}
-{"query_id": "924", "query_text": "Patients in stable partnerships have a slower progression from HIV to death.", "negative": "Satellite cell dysfunction is not a key factor in sarcopenia development.", "negatives": ["Satellite cell dysfunction is not a key factor in sarcopenia development.", "Pyridostatin delays checkpoint activation.", "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "Mitochondria play a major role in calcium homeostasis.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Serotonin receptors play a role in depression"], "hard_negatives": ["Patients in stable partnerships have a slower progression from HIV to death.", "Having a main partner lowers survival rates in HIV patients.", "Having a main partner increases survival rates in HIV patients.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Some countries have achieved the goal of eradicting malaria.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Higher initial mortality is associated with antidepressant use.", "Malaria has a low vectorial capacity."], "hard_negative": "Patients in stable partnerships have a slower progression from HIV to death."}
-{"query_id": "931", "query_text": "Patients with panic anxiety show increased CSF levels of hypocretin.", "negative": "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "negatives": ["Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Distant CREs are more conserved among species.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "NAC encourages the generation of angiotensin-converting enzyme.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom."], "hard_negatives": ["Patients with panic anxiety show increased CSF levels of hypocretin.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Serotonin receptors play a role in depression", "Serotonin receptors have no effect on depression", "Higher initial mortality is associated with antidepressant use.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Hypoglycemia decreases the risk of dementia.", "Rapamycin treatment raises G-CSF levels.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals."], "hard_negative": "Patients with panic anxiety show increased CSF levels of hypocretin."}
-{"query_id": "932", "query_text": "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "negative": "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "negatives": ["Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Obesity prolongs life expectancy.", "Aspirin encourages the production of PGE2.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "The minor G allele of FOXO3 represses IL-10.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled."], "hard_negatives": ["Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "The innate immune response is efficient at removing small numbers of parasites.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response."], "hard_negative": "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection."}
-{"query_id": "937", "query_text": "Persister cells lead to clinical relapse in cancer patients.", "negative": "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "negatives": ["Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "Participating in six months of physical activity impairs cognitive functioning.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries."], "hard_negatives": ["Persister cells lead to clinical relapse in cancer patients.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Metastases have genomic aberrations different than those of the primary tumor.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Participants who quit smoking reduce lung cancer risk by approximately 5%."], "hard_negative": "Persister cells lead to clinical relapse in cancer patients."}
-{"query_id": "943", "query_text": "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "negative": "Teaching hospitals provide better care than non-teaching hospitals.", "negatives": ["Teaching hospitals provide better care than non-teaching hospitals.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "RUNX is a top ranscription factor in skin tissue.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "In the UK, drowning affects boys at a higher rate than girls.", "Having a main partner lowers survival rates in HIV patients."], "hard_negatives": ["Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "p16INK4A accumulation is encoded by CDKN2A.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "LSD1 plays a role in transcriptional activation", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation."], "hard_negative": "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death."}
-{"query_id": "947", "query_text": "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "negative": "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "negatives": ["Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Excess nitric oxide is responsible for vasospasm.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "During the primary early antibody response activated B cells express low levels of EBI2."], "hard_negatives": ["Physical activity levels have been associated with the differences in VO2max between black and white youth.", "Obesity is determined in part by genetic factors.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Participating in six months of physical activity impairs cognitive functioning.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption."], "hard_negative": "Physical activity levels have been associated with the differences in VO2max between black and white youth."}
-{"query_id": "948", "query_text": "Physical injury activates transgultaminase activity.", "negative": "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "negatives": ["Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Some countries have achieved the goal of eradicting malaria.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Bariatric surgery has a deleterious impact on mental health.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Vitamin D deficiency has no effect on the term of child delivery."], "hard_negatives": ["Physical injury activates transgultaminase activity.", "Increased calcium levels repress transgultaminase activity.", "Increased calcium levels activate transgultaminase activity.", "Side effects associated with antidepressants decrease risk of stroke.", "Serotonin receptors play a role in depression", "Serotonin receptors have no effect on depression", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Autophagy deficiency in the liver protects from insulin resistance.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites."], "hard_negative": "Physical injury activates transgultaminase activity."}
-{"query_id": "950", "query_text": "Piezo1 channels are sensors for cell crowding in epithelial cells.", "negative": "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "negatives": ["De novo assembly of sequence data has longer contigs than unassembled sequence data.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "There is no relation between lupus erythematosus and cardiovascular disease", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "There is no relation between lupus erythematosus and cardiovascular disease"], "hard_negatives": ["Piezo1 channels are sensors for cell crowding in epithelial cells.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "CHEK2 has a significant role in breast cancer", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "\u03b21/Ketel is unable to bind microtubules.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a"], "hard_negative": "Piezo1 channels are sensors for cell crowding in epithelial cells."}
-{"query_id": "958", "query_text": "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "negative": "Vitamin D deficiency has no effect on the term of child delivery.", "negatives": ["Vitamin D deficiency has no effect on the term of child delivery.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "AZT given with ribavirin alleviates anemia.", "Vitamin D deficiency has no effect on the term of child delivery.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches."], "hard_negatives": ["Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367."], "hard_negative": "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses."}
-{"query_id": "961", "query_text": "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "negative": "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "negatives": ["Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Foxp3 displaces Foxo1 on chromatin", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Bronchial responsiveness is higher in the summer than in the winter.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Alirocumab treatment increases apo(a) fractional clearance rate.", "Higher initial mortality is associated with antidepressant use.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Metastases have genomic aberrations different than those of the primary tumor.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites."], "hard_negatives": ["Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Mitochondria are uninvolved in processes related to cell signaling.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Mitochondria play a major role in calcium homeostasis.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation."], "hard_negative": "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis."}
-{"query_id": "966", "query_text": "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "negative": "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "negatives": ["Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "All six cathelicidins are located on chromosome two.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "High cardiopulmonary fitness causes decreased mortality rate.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Side effects associated with antidepressants decrease risk of stroke.", "Choice of specialty is not influenced by debt accrued from medical training.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption."], "hard_negatives": ["Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Tet enzymes activate microRNAs required for iPSC derivation."], "hard_negative": "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs)."}
-{"query_id": "968", "query_text": "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "negative": "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "negatives": ["The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "RUNX is a top ranscription factor in skin tissue.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse."], "hard_negatives": ["Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "p16INK4A accumulation is encoded by CDKN2A.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy."], "hard_negative": "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation."}
-{"query_id": "974", "query_text": "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "negative": "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "negatives": ["Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "Excess nitric oxide is responsible for vasospasm.", "Sustained transmission of Avian influenza A between humans is not observed.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "CENP-B inhibits heterochromatin formation", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Obesity is determined in part by genetic factors."], "hard_negatives": ["Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia.", "Incidence rates of cervical cancer have increased over time.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa."], "hard_negative": "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia."}
-{"query_id": "981", "query_text": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "negative": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "negatives": ["Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Esrrb associates with BAF and Mbd3/NURD complexes.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Alirocumab treatment increases apo(a) fractional clearance rate."], "hard_negatives": ["Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Satellite cell dysfunction is not a key factor in sarcopenia development.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats."], "hard_negative": "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury."}
-{"query_id": "983", "query_text": "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "negative": "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "High cardiopulmonary fitness causes decreased mortality rate.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "N348I mutations decrease resistance to zidovudine (AZT).", "Low saturated fat diets have adverse effects on growth or development of infants.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "Autophagy increases in aged organisms.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1."], "hard_negatives": ["Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Mitochondria are uninvolved in processes related to cell signaling.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "\u03b21/Ketel is unable to bind microtubules.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation."], "hard_negative": "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body."}
-{"query_id": "986", "query_text": "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "negative": "NLRP12 is a positive regulator of T-cell receptor activation.", "negatives": ["NLRP12 is a positive regulator of T-cell receptor activation.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Short British students are bullied more than control British students.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "NR5A2 is important in bile acid homeostasis in humans.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Mitochondria play a major role in calcium homeostasis."], "hard_negatives": ["Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Gene expression can be highly variable across genetically identical cells.", "Genome size differences in rice are explained by LTR retrotransposon expansion."], "hard_negative": "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses."}
-{"query_id": "987", "query_text": "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "negative": "Obesity decreases life expectancy.", "negatives": ["Obesity decreases life expectancy.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "NAC encourages the generation of angiotensin-converting enzyme.", "Hypoglycemia decreases the risk of dementia.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "IL-10 production by monocytes encourages CD4 + T cell response."], "hard_negatives": ["Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "All six cathelicidins are located on chromosome two.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition."], "hard_negative": "Pseudoknots are evolutionarily conserved throughout most eukaryotes."}
-{"query_id": "991", "query_text": "Pyridostatin delays checkpoint activation.", "negative": "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "negatives": ["Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Patients in stable partnerships have a slower progression from HIV to death.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "The DESMOND program achieved a significant impact on lifestyles outcomes."], "hard_negatives": ["Pyridostatin delays checkpoint activation.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Autophagy deficiency in the liver protects from insulin resistance.", "Increased calcium levels repress transgultaminase activity."], "hard_negative": "Pyridostatin delays checkpoint activation."}
-{"query_id": "995", "query_text": "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "negative": "Obesity decreases life expectancy.", "negatives": ["Obesity decreases life expectancy.", "High levels of copeptin increase risk of diabetes.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Short British students are bullied less than control British students.", "Distant CREs are more conserved among species.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Increased calcium levels activate transgultaminase activity."], "hard_negatives": ["Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Pyridostatin delays checkpoint activation.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Mitochondria play a major role in calcium homeostasis.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Increased calcium levels activate transgultaminase activity.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Increased calcium levels repress transgultaminase activity."], "hard_negative": "Pyridostatin increases telomere fragility in BRCA2-deficient cells."}
-{"query_id": "1007", "query_text": "RUNX is a top ranscription factor in skin tissue.", "negative": "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Autophagy deficiency in the liver protects from insulin resistance.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Serotonin receptors have no effect on depression", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "G-CSF prevents MDSCs from infiltrating tumors."], "hard_negatives": ["RUNX is a top ranscription factor in skin tissue.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Notch signalling can occur between tumor cells and stromal cells.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "LRBA controls CTLA - 4 expression."], "hard_negative": "RUNX is a top ranscription factor in skin tissue."}
-{"query_id": "1010", "query_text": "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "negative": "Side effects associated with antidepressants decrease risk of stroke.", "negatives": ["Side effects associated with antidepressants decrease risk of stroke.", "Short British students are bullied more than control British students.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Physical injury activates transgultaminase activity.", "IL-10 production by monocytes encourages CD4 + T cell response.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine."], "hard_negatives": ["Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "Incidence of sepsis has remained stable between 2009-2014.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "During the primary early antibody response activated B cells express high levels of EBI2.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Tuberculosis incidence is correlated with residential crowding in the UK."], "hard_negative": "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values."}
-{"query_id": "1013", "query_text": "Rapamycin accelerates aging in fruit flies.", "negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Having a main partner lowers survival rates in HIV patients.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Satellite cell dysfunction is not a key factor in sarcopenia development.", "High levels of copeptin increase risk of diabetes.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Sustained transmission of Avian influenza A between humans is not observed.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection."], "hard_negatives": ["Rapamycin accelerates aging in fruit flies.", "Autophagy deficiency in the liver protects from insulin resistance.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Rapamycin treatment raises G-CSF levels.", "The innate immune response is efficient at removing small numbers of parasites.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Autophagy increases in aged organisms.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity."], "hard_negative": "Rapamycin accelerates aging in fruit flies."}
-{"query_id": "1017", "query_text": "Rapamycin treatment raises G-CSF levels.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "The number of Ndc80 complexes varies with cell cycle timing.", "Self-advocacy training is not effective at decreasing homelessness.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Higher initial mortality is associated with antidepressant use."], "hard_negatives": ["Rapamycin treatment raises G-CSF levels.", "G-CSF prevents MDSCs from infiltrating tumors.", "AZT given with ribavirin alleviates anemia.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "A deficiency of folate decreases blood levels of homocysteine.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Increased calcium levels activate transgultaminase activity."], "hard_negative": "Rapamycin treatment raises G-CSF levels."}
-{"query_id": "1022", "query_text": "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "negative": "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "negatives": ["Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "The number of Ndc80 complexes varies with cell cycle timing.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Choice of specialty is not influenced by debt accrued from medical training.", "Obesity prolongs life expectancy.", "De novo assembly of sequence data has longer contigs than unassembled sequence data.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress."], "hard_negatives": ["Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "High levels of copeptin increase risk of diabetes.", "Autophagy deficiency in the liver protects from insulin resistance.", "Side effects associated with antidepressants decrease risk of stroke.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Hypoglycemia decreases the risk of dementia.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Bariatric surgery reduces resolution of diabetes."], "hard_negative": "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects."}
-{"query_id": "1039", "query_text": "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "negative": "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "negatives": ["Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "The number of Ndc80 complexes varies with cell cycle timing.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Vitamin D deficiency has no effect on the term of child delivery.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors."], "hard_negatives": ["Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions."], "hard_negative": "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells."}
-{"query_id": "1051", "query_text": "Risedronate reduces risk of vertebral and non-vertebral fractures.", "negative": "Colloid exposure causes morbidity.", "negatives": ["Colloid exposure causes morbidity.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "\u03b21/Ketel is unable to bind microtubules.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death."], "hard_negatives": ["Risedronate reduces risk of vertebral and non-vertebral fractures.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Bariatric surgery reduces resolution of diabetes.", "A deficiency of folate decreases blood levels of homocysteine.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors."], "hard_negative": "Risedronate reduces risk of vertebral and non-vertebral fractures."}
-{"query_id": "1057", "query_text": "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "negative": "AZT given with ribavirin alleviates anemia.", "negatives": ["AZT given with ribavirin alleviates anemia.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Incidence of sepsis has remained stable between 2009-2014."], "hard_negatives": ["Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Bariatric surgery has a deleterious impact on mental health.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Incidence rates of cervical cancer have increased over time.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women."], "hard_negative": "Roughly 10% of women with chronic pelvic pain have no underlying pathology."}
-{"query_id": "1059", "query_text": "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "negative": "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "negatives": ["p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Higher initial mortality is associated with antidepressant use.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "Serotonin receptors have no effect on depression", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Obesity prolongs life expectancy.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "All phenotypes associated with reduced IIS require the gene daf-16."], "hard_negatives": ["Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites."], "hard_negative": "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues."}
-{"query_id": "1060", "query_text": "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "negative": "KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "negatives": ["KLF4 prevents VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "\u03b21/Ketel is unable to bind microtubules.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Obesity prolongs life expectancy."], "hard_negatives": ["Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells."], "hard_negative": "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues."}
-{"query_id": "1061", "query_text": "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "negative": "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "negatives": ["Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Mitochondria play a major role in calcium homeostasis.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "The DESMOND program achieved a significant impact on lifestyles outcomes."], "hard_negatives": ["S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "p16INK4A accumulation is encoded by CDKN2A.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus."], "hard_negative": "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase."}
-{"query_id": "1063", "query_text": "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "negative": "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "negatives": ["Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "There is no relation between lupus erythematosus and cardiovascular disease", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Colloid exposure causes morbidity.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."], "hard_negatives": ["S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Tet enzymes activate microRNAs required for iPSC derivation.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs)."], "hard_negative": "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins."}
-{"query_id": "1064", "query_text": "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "negative": "Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "negatives": ["Pretreatment with the Arp2/3 inhibitor CK-666 is not associated with lamelliopodia formation.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "All phenotypes associated with reduced IIS require the gene daf-16.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "NR5A2 is important in bile acid homeostasis in humans.", "High cardiopulmonary fitness causes decreased mortality rate."], "hard_negatives": ["SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Autophagy deficiency in the liver protects from insulin resistance.", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "Autophagy increases in aged organisms."], "hard_negative": "SOD1 integrates oxygen and glucose signals to repress cellular respiration."}
-{"query_id": "1066", "query_text": "Satellite cell dysfunction is not a key factor in sarcopenia development.", "negative": "Obesity decreases life expectancy.", "negatives": ["Obesity decreases life expectancy.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "PEP carboxylase enhances threonine production in E. coli.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "The DESMOND program significantly improves biochemical outcomes.", "Consumption of whole fruits reduces the risk of type 2 diabetes."], "hard_negatives": ["Satellite cell dysfunction is not a key factor in sarcopenia development.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Vitamin D deficiency has no effect on the term of child delivery.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls."], "hard_negative": "Satellite cell dysfunction is not a key factor in sarcopenia development."}
-{"query_id": "1071", "query_text": "Self-advocacy training is not effective at decreasing homelessness.", "negative": "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "negatives": ["Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Some countries have achieved the goal of eradicting malaria.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "Bronchial responsiveness is higher in the summer than in the winter.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons."], "hard_negatives": ["Self-advocacy training is not effective at decreasing homelessness.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Having a main partner lowers survival rates in HIV patients.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Higher initial mortality is associated with antidepressant use.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Having a main partner increases survival rates in HIV patients.", "Bariatric surgery has a deleterious impact on mental health."], "hard_negative": "Self-advocacy training is not effective at decreasing homelessness."}
-{"query_id": "1076", "query_text": "Serotonin receptors have no effect on depression", "negative": "p16INK4A accumulation is encoded by CDKN2A.", "negatives": ["p16INK4A accumulation is encoded by CDKN2A.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Mitochondria are uninvolved in processes related to cell signaling.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Increased calcium levels repress transgultaminase activity.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance."], "hard_negatives": ["Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "LSD1 plays a role in transcriptional activation"], "hard_negative": "Serotonin receptors have no effect on depression"}
-{"query_id": "1077", "query_text": "Serotonin receptors play a role in depression", "negative": "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "negatives": ["Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Aspirin encourages the production of PGE2.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "Higher initial mortality is associated with antidepressant use.", "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP."], "hard_negatives": ["Serotonin receptors play a role in depression", "Serotonin receptors have no effect on depression", "Side effects associated with antidepressants decrease risk of stroke.", "LSD1 plays a role in transcriptional activation", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1."], "hard_negative": "Serotonin receptors play a role in depression"}
-{"query_id": "1078", "query_text": "Short British students are bullied less than control British students.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "There is no relation between lupus erythematosus and cardiovascular disease", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption."], "hard_negatives": ["Short British students are bullied more than control British students.", "Short British students are bullied less than control British students.", "In the UK, drowning affects boys at a higher rate than girls.", "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Teaching hospitals provide better care than non-teaching hospitals.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)."], "hard_negative": "Short British students are bullied more than control British students."}
-{"query_id": "1079", "query_text": "Short British students are bullied more than control British students.", "negative": "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "negatives": ["Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Obesity prolongs life expectancy.", "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Correlative electron microscopy and superresolution fluorescence imaging are imaging techniques."], "hard_negatives": ["Short British students are bullied more than control British students.", "Short British students are bullied less than control British students.", "In the UK, drowning affects boys at a higher rate than girls.", "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Teaching hospitals provide better care than non-teaching hospitals."], "hard_negative": "Short British students are bullied more than control British students."}
-{"query_id": "1080", "query_text": "Side effects associated with antidepressants decrease risk of stroke.", "negative": "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "negatives": ["Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "G-CSF prevents MDSCs from infiltrating tumors.", "Suboptimal nutrition is a leading cause of chronic disease", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway."], "hard_negatives": ["Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Higher initial mortality is associated with antidepressant use.", "Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy."], "hard_negative": "Side effects associated with antidepressants decrease risk of stroke."}
-{"query_id": "1082", "query_text": "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "negative": "Tuberculosis incidence is correlated with residential crowding in the UK.", "negatives": ["Tuberculosis incidence is correlated with residential crowding in the UK.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA."], "hard_negatives": ["Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Higher initial mortality is associated with antidepressant use.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Serotonin receptors have no effect on depression", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "Serotonin receptors play a role in depression", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer"], "hard_negative": "Side effects associated with antidepressants increases risk of mortality in postmenopausal women."}
-{"query_id": "1083", "query_text": "Side effects associated with antidepressants increases risk of myocardial infarction.", "negative": "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "negatives": ["Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "NR5A2 is important in bile acid homeostasis in humans.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "The minor G allele of FOXO3 represses IL-10.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "PEP carboxylase enhances threonine production in E. coli.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants increases risk of myocardial infarction."], "hard_negatives": ["Side effects associated with antidepressants increases risk of myocardial infarction.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Higher initial mortality is associated with antidepressant use.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Serotonin receptors have no effect on depression", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Serotonin receptors play a role in depression"], "hard_negative": "Side effects associated with antidepressants increases risk of myocardial infarction."}
-{"query_id": "1092", "query_text": "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "negative": "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "negatives": ["p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "PEP carboxylase suppresses threonine production in E. coli.", "The DESMOND program significantly improves biochemical outcomes.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites."], "hard_negatives": ["Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "N348I mutations decrease resistance to zidovudine (AZT).", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "CHEK2 has a significant role in breast cancer", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "A deficiency of folate decreases blood levels of homocysteine.", "A deficiency of vitamin B6 increases blood levels of homocysteine."], "hard_negative": "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia."}
-{"query_id": "1093", "query_text": "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "negative": "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "negatives": ["S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Foxp3 displaces Foxo1 on chromatin", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "All six cathelicidins are located on chromosome two."], "hard_negatives": ["Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "N348I mutations decrease resistance to zidovudine (AZT).", "CHEK2 has a significant role in breast cancer", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "A deficiency of folate decreases blood levels of homocysteine.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."], "hard_negative": "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia."}
-{"query_id": "1094", "query_text": "Some countries have achieved the goal of eradicting malaria.", "negative": "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "negatives": ["The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Ginger is safe for mechanically ventilated patients.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa."], "hard_negatives": ["Some countries have achieved the goal of eradicting malaria.", "Malaria has a low vectorial capacity.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Sustained transmission of Avian influenza A between humans is not observed.", "Incidence rates of cervical cancer have increased over time.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "The innate immune response is efficient at removing small numbers of parasites.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Patients in stable partnerships have a slower progression from HIV to death."], "hard_negative": "Some countries have achieved the goal of eradicting malaria."}
-{"query_id": "1095", "query_text": "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "negative": "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "negatives": ["The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Mitochondria are uninvolved in processes related to cell signaling.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia."], "hard_negatives": ["Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Tet enzymes activate microRNAs required for iPSC derivation."], "hard_negative": "Some signals for alternative polyadenylation sites are encoded in transposable elements."}
-{"query_id": "1108", "query_text": "Suboptimal nutrition is a leading cause of chronic disease", "negative": "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "negatives": ["Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Colloid exposure causes morbidity.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Genetic deletion of JAM-A decreases gut permeability.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Golli-deficient T-cells are dormant in initial clonal expansion."], "hard_negatives": ["Suboptimal nutrition is a leading cause of chronic disease", "Obesity is determined in part by genetic factors.", "Malaria has a low vectorial capacity.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Obesity prolongs life expectancy.", "Obesity prolongs life expectancy.", "Low saturated fat diets have adverse effects on growth or development of infants.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries."], "hard_negative": "Suboptimal nutrition is a leading cause of chronic disease"}
-{"query_id": "1113", "query_text": "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "negative": "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "negatives": ["Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Obesity decreases life expectancy.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Physical injury activates transgultaminase activity.", "Genetic deletion of JAM-A decreases gut permeability.", "LRBA controls CTLA - 4 expression.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negatives": ["Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Myelin sheaths play an important role in trophic support.", "Mitochondria are uninvolved in processes related to cell signaling.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings."], "hard_negative": "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs."}
-{"query_id": "1116", "query_text": "Sustained transmission of Avian influenza A between humans is not observed.", "negative": "Obesity prolongs life expectancy.", "negatives": ["Obesity prolongs life expectancy.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "All six cathelicidins are located on chromosome two.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "A deficiency of folate decreases blood levels of homocysteine.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove."], "hard_negatives": ["Sustained transmission of Avian influenza A between humans is not observed.", "Malaria has a low vectorial capacity.", "Some countries have achieved the goal of eradicting malaria.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "The innate immune response is efficient at removing small numbers of parasites.", "Colloid exposure has no effect on morbidity."], "hard_negative": "Sustained transmission of Avian influenza A between humans is not observed."}
-{"query_id": "1117", "query_text": "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "negative": "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "negatives": ["Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "Myelin sheaths play an important role in trophic support.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "LSD1 plays a role in transcriptional activation", "Side effects associated with antidepressants decrease risk of stroke.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses."], "hard_negatives": ["Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Autophagy deficiency in the liver protects from insulin resistance.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Serotonin receptors have no effect on depression", "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose."], "hard_negative": "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose."}
-{"query_id": "1122", "query_text": "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "negative": "Side effects associated with antidepressants decrease risk of stroke.", "negatives": ["Side effects associated with antidepressants decrease risk of stroke.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Metastases have genomic aberrations different than those of the primary tumor.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "PRC1-bound plasmids sediment at a faster rate in unbound plasmids than in sucrose gradients.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "CHEK2 has a significant role in breast cancer"], "hard_negatives": ["Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process."], "hard_negative": "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites."}
-{"query_id": "1123", "query_text": "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "negative": "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "negatives": ["Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Rapamycin accelerates aging in fruit flies.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses."], "hard_negatives": ["Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Serotonin receptors have no effect on depression", "Serotonin receptors play a role in depression", "p53 controls autophagy through the AMPK/mTOR-dependent pathway."], "hard_negative": "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites."}
-{"query_id": "1124", "query_text": "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "negative": "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "negatives": ["8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Long-term use of statins showed a decreased risk of gallstones followed by cholecystectomy.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Ginger is safe for mechanically ventilated patients.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Bariatric surgery reduces resolution of diabetes.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "High cardiopulmonary fitness causes decreased mortality rate."], "hard_negatives": ["Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Serotonin receptors have no effect on depression", "There are four spatial channels in each hemifield of the auditory cortex of cats."], "hard_negative": "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites."}
-{"query_id": "1129", "query_text": "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "negative": "Bariatric surgery reduces resolution of diabetes.", "negatives": ["Bariatric surgery reduces resolution of diabetes.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Colloid exposure causes morbidity.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Genetic deletion of JAM-A decreases gut permeability.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile"], "hard_negatives": ["T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "NLRP12 is a positive regulator of T-cell receptor activation.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface."], "hard_negative": "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse."}
-{"query_id": "1131", "query_text": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "negative": "Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "negatives": ["Near-infrared wavelengths decrease penetration depth in fiberoptic confocal microscopy.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Having a main partner increases survival rates in HIV patients.", "Genetic deletion of JAM-A decreases gut permeability.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Aspirin encourages the production of PGE2.", "Autophagy increases in aged organisms."], "hard_negatives": ["T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "NLRP12 is a positive regulator of T-cell receptor activation.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue."], "hard_negative": "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation."}
-{"query_id": "1143", "query_text": "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "negative": "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "negatives": ["Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening.", "Rapamycin treatment raises G-CSF levels.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "A deficiency of vitamin B6 increases blood levels of homocysteine."], "hard_negatives": ["Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Side effects associated with antidepressants decrease risk of stroke.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Higher initial mortality is associated with antidepressant use.", "During the primary early antibody response activated B cells express high levels of EBI2.", "AZT given with ribavirin alleviates anemia.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome."], "hard_negative": "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals."}
-{"query_id": "1147", "query_text": "Teaching hospitals provide better care than non-teaching hospitals.", "negative": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "negatives": ["Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of atopic eczema at 1 year.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "There is no relation between lupus erythematosus and cardiovascular disease", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "PEP carboxylase suppresses threonine production in E. coli.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Patients in stable partnerships have a slower progression from HIV to death.", "Having a main partner increases survival rates in HIV patients."], "hard_negatives": ["Teaching hospitals provide better care than non-teaching hospitals.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Choice of specialty is not influenced by debt accrued from medical training.", "Bariatric surgery has a deleterious impact on mental health.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Bariatric surgery reduces resolution of diabetes.", "Patients in stable partnerships have a slower progression from HIV to death."], "hard_negative": "Teaching hospitals provide better care than non-teaching hospitals."}
-{"query_id": "1149", "query_text": "Tet enzymes activate microRNAs required for iPSC derivation.", "negative": "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "negatives": ["CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Tet enzymes activate microRNAs required for iPSC derivation.", "NAC encourages the generation of angiotensin-converting enzyme.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Cellular aging is uncorrelated with an older appearance.", "Colloid exposure causes morbidity.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico."], "hard_negatives": ["Tet enzymes activate microRNAs required for iPSC derivation.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation."], "hard_negative": "Tet enzymes activate microRNAs required for iPSC derivation."}
-{"query_id": "1151", "query_text": "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "negative": "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "negatives": ["Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1."], "hard_negatives": ["The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Side effects associated with antidepressants decrease risk of stroke.", "Higher initial mortality is associated with antidepressant use.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Side effects associated with antidepressants increases risk of myocardial infarction.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Serotonin receptors have no effect on depression"], "hard_negative": "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy."}
-{"query_id": "1152", "query_text": "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "negative": "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "negatives": ["Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Rapamycin treatment raises G-CSF levels.", "G-CSF prevents MDSCs from infiltrating tumors.", "High cardiopulmonary fitness causes decreased mortality rate.", "Lmna knock-in models are not suitable to test therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS).", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Gene expression can be highly variable across genetically identical cells.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death."], "hard_negatives": ["The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Higher initial mortality is associated with antidepressant use.", "Side effects associated with antidepressants decrease risk of stroke.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Side effects associated with antidepressants increases risk of myocardial infarction.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources."], "hard_negative": "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy."}
-{"query_id": "1154", "query_text": "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "negative": "There are four spatial channels in each hemifield of the auditory cortex of cats.", "negatives": ["There are four spatial channels in each hemifield of the auditory cortex of cats.", "Bronchial responsiveness is the same in the winter and summer seasons.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Pyridostatin delays checkpoint activation.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women."], "hard_negatives": ["The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Mitochondria play a major role in calcium homeostasis.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers."], "hard_negative": "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces."}
-{"query_id": "1155", "query_text": "The DESMOND program achieved a significant impact on lifestyles outcomes.", "negative": "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "negatives": ["8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "In the UK, drowning affects boys at a higher rate than girls.", "Oral ibandronate reduces relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Osteocytes are not associated with G-CSF induced HSPC mobilization."], "hard_negatives": ["The DESMOND program achieved a significant impact on lifestyles outcomes.", "The DESMOND program significantly improves biochemical outcomes.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Self-advocacy training is not effective at decreasing homelessness.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "Vitamin D deficiency has no effect on the term of child delivery.", "Combination nicotine replacement therapies with varenicline or bupropion are not associated with significantly higher long-term abstinence rates at 52 weeks than varenicline monotherapy.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events"], "hard_negative": "The DESMOND program achieved a significant impact on lifestyles outcomes."}
-{"query_id": "1160", "query_text": "The DESMOND program significantly improves biochemical outcomes.", "negative": "Gastric lavage shows no benefit for acute paraquat poisoning.", "negatives": ["Gastric lavage shows no benefit for acute paraquat poisoning.", "\u03b21/Ketel is unable to bind microtubules.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "DUSP4 downregulation activates the Ras-ERK pathway", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "NLRP12 is a positive regulator of T-cell receptor activation.", "Obesity prolongs life expectancy."], "hard_negatives": ["The DESMOND program significantly improves biochemical outcomes.", "The DESMOND program achieved a significant impact on lifestyles outcomes.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Some countries have achieved the goal of eradicting malaria."], "hard_negative": "The DESMOND program significantly improves biochemical outcomes."}
-{"query_id": "1167", "query_text": "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "negative": "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "negatives": ["Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Major vault protein (MVP) functions to decrease tumor aggression.", "CRY proteins mediate light signal transduction.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "G-CSF prevents MDSCs from infiltrating tumors.", "Obesity decreases life expectancy.", "Nrde-3 facilitates heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus.", "Self-advocacy training is not effective at decreasing homelessness."], "hard_negatives": ["The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "N348I mutations decrease resistance to zidovudine (AZT).", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Foxp3 displaces Foxo1 on chromatin", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids."], "hard_negative": "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated."}
-{"query_id": "1172", "query_text": "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "negative": "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "negatives": ["Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Sweet taste receptors on the tongue are activated by between 300 and 1000 mM glucose.", "Side effects associated with antidepressants decrease risk of stroke.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "Obesity prolongs life expectancy.", "Incidence rates of cervical cancer have increased over time.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "Bronchial responsiveness is higher in the summer than in the winter.", "Mitochondria play a major role in calcium homeostasis."], "hard_negatives": ["The PDPN gene activates the C-type lectin receptor (CLEC-2).", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Serotonin receptors play a role in depression", "mTORC2 inhibits xCT antiporter through phosphorylation.", "NLRP12 is a positive regulator of T-cell receptor activation.", "Serotonin receptors have no effect on depression", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "LSD1 plays a role in transcriptional activation", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."], "hard_negative": "The PDPN gene activates the C-type lectin receptor (CLEC-2)."}
-{"query_id": "1189", "query_text": "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "negative": "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "negatives": ["Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Teaching hospitals provide better care than non-teaching hospitals.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "The minor G allele of FOXO3 represses IL-10.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "DUSP4 downregulation activates the Ras-ERK pathway"], "hard_negatives": ["The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Distant CREs are more conserved among species.", "All six cathelicidins are located on chromosome two.", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers."], "hard_negative": "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes."}
-{"query_id": "1192", "query_text": "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "negative": "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "negatives": ["Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Mitochondria are uninvolved in processes related to cell signaling.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Long-term use of statins showed a increased risk of gallstones followed by cholecystectomy.", "Choice of specialty is not influenced by debt accrued from medical training.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negatives": ["The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Mitochondria play a major role in calcium homeostasis.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "RUNX is a top ranscription factor in skin tissue.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites."], "hard_negative": "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat."}
-{"query_id": "1198", "query_text": "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "negative": "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "negatives": ["The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Pyridostatin increases telomere fragility in BRCA2-deficient cells.", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Short British students are bullied less than control British students.", "Distant CREs are more conserved among species.", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Tet enzymes activate microRNAs required for iPSC derivation."], "hard_negatives": ["The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Serotonin receptors play a role in depression"], "hard_negative": "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex."}
-{"query_id": "1201", "query_text": "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "negative": "Persister cells lead to clinical relapse in cancer patients.", "negatives": ["Persister cells lead to clinical relapse in cancer patients.", "Serotonin receptors have no effect on depression", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "AZT given with ribavirin alleviates anemia.", "Consumption of whole fruits reduces the risk of type 2 diabetes.", "\u03b21/Ketel is unable to bind microtubules.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negatives": ["The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "LSD1 plays a role in transcriptional activation", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "All phenotypes associated with reduced IIS require the gene daf-16."], "hard_negative": "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1."}
-{"query_id": "1203", "query_text": "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "negative": "Self-advocacy training is not effective at decreasing homelessness.", "negatives": ["Self-advocacy training is not effective at decreasing homelessness.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "CENP-B inhibits heterochromatin formation", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight."], "hard_negatives": ["The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "G-CSF prevents MDSCs from infiltrating tumors.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA."], "hard_negative": "The center of the granuloma in an immune cell induces an anti-inflammatory immune response."}
-{"query_id": "1217", "query_text": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negative": "The innate immune response is efficient at removing small numbers of parasites.", "negatives": ["The innate immune response is efficient at removing small numbers of parasites.", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "N348I mutations decrease resistance to zidovudine (AZT).", "The DESMOND program significantly improves biochemical outcomes.", "Tet enzymes activate microRNAs required for iPSC derivation.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Serotonin receptors play a role in depression", "The innate immune response is efficient at removing small numbers of parasites."], "hard_negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function."], "hard_negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."}
-{"query_id": "1222", "query_text": "The innate immune response is efficient at removing small numbers of parasites.", "negative": "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "negatives": ["Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Teaching hospitals provide better care than non-teaching hospitals.", "Cyclin A2 synthesis is necessary to switch from unstable to stable kt-mt attachments in mitosis.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Allele and genotype frequencies of the rs4516035 and rs2298850 SNPs in Mexican populations are associated with region in Mexico.", "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "The number of Ndc80 complexes varies with cell cycle timing.", "Low saturated fat diets do not have adverse effects on growth or development of infants."], "hard_negatives": ["The innate immune response is efficient at removing small numbers of parasites.", "Malaria has a low vectorial capacity.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Some countries have achieved the goal of eradicting malaria.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection."], "hard_negative": "The innate immune response is efficient at removing small numbers of parasites."}
-{"query_id": "1233", "query_text": "The minor G allele of FOXO3 represses IL-10.", "negative": "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "negatives": ["Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Choice of specialty is not influenced by debt accrued from medical training.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "High levels of copeptin increase risk of diabetes.", "Malaria has a low vectorial capacity.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus."], "hard_negatives": ["The minor G allele of FOXO3 represses IL-10.", "Foxp3 displaces Foxo1 on chromatin", "IL-10 production by monocytes encourages CD4 + T cell response.", "During the primary early antibody response activated B cells express low levels of EBI2.", "During the primary early antibody response activated B cells express high levels of EBI2.", "All phenotypes associated with reduced IIS require the gene daf-16.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "NLRP12 is a positive regulator of T-cell receptor activation.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negative": "The minor G allele of FOXO3 represses IL-10."}
-{"query_id": "1240", "query_text": "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "negative": "Bronchial responsiveness is the same in the winter and summer seasons.", "negatives": ["Bronchial responsiveness is the same in the winter and summer seasons.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Synaptic activity impairs local release of brain derived neurotrophic factor from postsynaptic dendrites.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells."], "hard_negatives": ["The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Cellular aging is uncorrelated with an older appearance.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year."], "hard_negative": "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin."}
-{"query_id": "1242", "query_text": "The number of Ndc80 complexes varies with cell cycle timing.", "negative": "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "negatives": ["Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "Physical activity levels have been associated with the differences in VO2max between black and white youth.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1."], "hard_negatives": ["The number of Ndc80 complexes varies with cell cycle timing.", "N348I mutations decrease resistance to zidovudine (AZT).", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Gene expression can be highly variable across genetically identical cells.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove."], "hard_negative": "The number of Ndc80 complexes varies with cell cycle timing."}
-{"query_id": "1243", "query_text": "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "negative": "Having a main partner lowers survival rates in HIV patients.", "negatives": ["Having a main partner lowers survival rates in HIV patients.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Side effects associated with antidepressants decrease risk of stroke.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Rapamycin treatment raises G-CSF levels.", "Myelin sheaths play an important role in trophic support.", "Metastases have genomic aberrations different than those of the primary tumor."], "hard_negatives": ["The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "Autophagy increases in aged organisms.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Vitamin D deficiency has no effect on the term of child delivery.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis"], "hard_negative": "The number of unfertilized oocytes in mated hermaphrodites decreases with age."}
-{"query_id": "1250", "query_text": "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "negative": "8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "negatives": ["8% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Patients in stable partnerships have a slower progression from HIV to death.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Participating in six months of physical activity impairs cognitive functioning.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "G-CSF prevents MDSCs from infiltrating tumors.", "The myocardial cell lineage originally develops from cardiac progenitors of mesodermal origin."], "hard_negatives": ["The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "F4/80+ macrophages are located in the periosteum.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation."], "hard_negative": "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings."}
-{"query_id": "1251", "query_text": "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "negative": "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "negatives": ["CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels.", "The DESMOND program significantly improves biochemical outcomes.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome.", "Synaptic activity enhances local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Rapamycin accelerates aging in fruit flies.", "Induction of urokinase receptor signaling in podocytes has no effect on foot process effacement and proteinuria.", "NAC stabilizes NO to reduce the effect of contrast agents on renal functions.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Incidence rates of cervical cancer have increased over time."], "hard_negatives": ["The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Foxp3 displaces Foxo1 on chromatin", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation."], "hard_negative": "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."}
-{"query_id": "1252", "query_text": "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "negative": "All phenotypes associated with reduced IIS require the gene daf-16.", "negatives": ["All phenotypes associated with reduced IIS require the gene daf-16.", "Chronic aerobic exercise alters endothelial function, impairing vasodilating mechanisms mediated by NO.", "Obesity prolongs life expectancy.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "Distant CREs are more conserved among species.", "The DESMOND program achieved a significant impact on lifestyles outcomes.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Replacement of OCT4 and SOX2 genes with mesendoderm-related genes has the ability to reprogram human cells.", "c-MYC is important for maintaining pluripotent state of pluripotent stem cells."], "hard_negatives": ["The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "DUSP4 downregulation activates the Ras-ERK pathway"], "hard_negative": "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)."}
-{"query_id": "1256", "query_text": "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "negative": "Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "negatives": ["Inhibiting HDAC6 decreases survival of mice with ARID1A mutated tumors.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Cellular aging is uncorrelated with an older appearance.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "During the primary early antibody response activated B cells express low levels of EBI2.", "Obesity is determined in part by genetic factors.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "High cardiopulmonary fitness causes decreased mortality rate."], "hard_negatives": ["The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Some countries have achieved the goal of eradicting malaria.", "Obesity is determined in part by genetic factors.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Malaria has a low vectorial capacity.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy."], "hard_negative": "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries."}
-{"query_id": "1264", "query_text": "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "negative": "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "negatives": ["Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "A deficiency of folate decreases blood levels of homocysteine.", "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Glucose restriction to 0.05% increases RLS (replicative life span) by 20-40% in S. cerevisiae.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "N348I mutations decrease resistance to zidovudine (AZT).", "Genetic deletion of JAM-A decreases gut permeability.", "Esrrb associates with BAF and Mbd3/NURD complexes."], "hard_negatives": ["The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Mitochondria are uninvolved in processes related to cell signaling.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Gene expression can be highly variable across genetically identical cells.", "The number of Ndc80 complexes varies with cell cycle timing.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings."], "hard_negative": "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers."}
-{"query_id": "1267", "query_text": "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "negative": "Monoclonal antibody targeting of N-cadherin promotes growth.", "negatives": ["Monoclonal antibody targeting of N-cadherin promotes growth.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Teaching hospitals provide better care than non-teaching hospitals.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Incidence rates of cervical cancer have increased over time.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "T cell receptor /CD3 microdomains are unnecessary in the induction of the immunlogical synapse."], "hard_negatives": ["The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Participants who quit smoking reduce lung cancer risk by approximately 5%.", "Hypoglycemia decreases the risk of dementia.", "Incidence rates of cervical cancer have increased over time.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Side effects associated with antidepressants decrease risk of stroke.", "Higher initial mortality is associated with antidepressant use.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight."], "hard_negative": "The risk of cancer is lower in individuals with a history of heavy alcohol consumption."}
-{"query_id": "1277", "query_text": "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "negative": "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "negatives": ["Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "The DESMOND program significantly improves biochemical outcomes.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Having a main partner lowers survival rates in HIV patients.", "Bariatric surgery has a deleterious impact on mental health.", "Short British students are bullied more than control British students.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "A deficiency of vitamin B6 increases blood levels of homocysteine.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Healthy volunteers exhibit rapid and transient decrease of cellular ATP after being bolus-injected with fructose."], "hard_negatives": ["The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "The innate immune response is efficient at removing small numbers of parasites."], "hard_negative": "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response."}
-{"query_id": "1283", "query_text": "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "negative": "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "negatives": ["Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Impaired RhoA activity causes megakaryocytes to exit mitosis without complete karyokinesis", "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Ginger is hazardous to mechanically ventilated patients, because these patients are susceptible to mucosal lesions and ulcers.", "The DESMOND program significantly improves biochemical outcomes.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "F4/80+ macrophages are located in the periosteum.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "Vitamin D deficiency has no effect on the term of child delivery."], "hard_negatives": ["Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events", "Higher initial mortality is associated with antidepressant use.", "Side effects associated with antidepressants decrease risk of stroke.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Side effects associated with antidepressants increases risk of myocardial infarction.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma."], "hard_negative": "Therapeutics receiving accelerated approval encounter a higher frequency of post-marketing safety events"}
-{"query_id": "1285", "query_text": "There are four spatial channels in each hemifield of the auditory cortex of cats.", "negative": "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "negatives": ["Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "Obesity prolongs life expectancy.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "Higher initial mortality is associated with antidepressant use.", "Having a main partner lowers survival rates in HIV patients.", "Pyridostatin delays checkpoint activation.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "CENP-B inhibits heterochromatin formation", "C. elegans germlines lose their immortal character when nuclear RNAi is activated."], "hard_negatives": ["There are four spatial channels in each hemifield of the auditory cortex of cats.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "Supracellular actomyosin structures are found at boundaries in Drosophila wing imaginal discs.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "All six cathelicidins are located on chromosome two.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls."], "hard_negative": "There are four spatial channels in each hemifield of the auditory cortex of cats."}
-{"query_id": "1286", "query_text": "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "negative": "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "negatives": ["Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "Cell autonomous sex determination in somatic cells does not occur in Passeriformes.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Obesity is determined in part by genetic factors.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "High cardiopulmonary fitness causes decreased mortality rate.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1."], "hard_negatives": ["There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues."], "hard_negative": "There are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients."}
-{"query_id": "1287", "query_text": "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "negative": "Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "negatives": ["Presence of stemloops is important for reverse transcription in short interspersed nuclear elements (SINEs).", "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "The risk of cancer is lower in individuals with a history of heavy alcohol consumption.", "Decreases in region specific aerobic glycolysis in aged humans slows aging induced changes in brain glucose metabolism.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "High cardiopulmonary fitness causes decreased mortality rate.", "Incidence of sepsis has remained stable between 2009-2014.", "Higher initial mortality is associated with antidepressant use.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids."], "hard_negatives": ["There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Serotonin receptors have no effect on depression", "DUSP4 downregulation activates the Ras-ERK pathway", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Serotonin receptors play a role in depression", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation."], "hard_negative": "There is a neuroprotective effect of Trpm4 inhibition in mice and rats."}
-{"query_id": "1296", "query_text": "There is no relation between lupus erythematosus and cardiovascular disease", "negative": "The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "negatives": ["The phosphorylation of Drp1 at S616 site promotes its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Genes regulated by Esrrb transcription factor are unaffected by Mbd3 function.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Malaria has a low vectorial capacity.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Incidence of sepsis has remained stable between 2009-2014.", "Having a main partner lowers survival rates in HIV patients.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress."], "hard_negatives": ["There is no relation between lupus erythematosus and cardiovascular disease", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "High cardiopulmonary fitness causes decreased mortality rate.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Sustained transmission of Avian influenza A between humans is not observed.", "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Bariatric surgery has a deleterious impact on mental health.", "Side effects associated with antidepressants decrease risk of stroke."], "hard_negative": "There is no relation between lupus erythematosus and cardiovascular disease"}
-{"query_id": "1299", "query_text": "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "negative": "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "negatives": ["SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "All phenotypes associated with reduced IIS require the gene daf-16.", "Bariatric surgery reduces resolution of diabetes.", "Suboptimal nutrition is a leading cause of chronic disease", "Amitriptyline ineffective as a treatment for chronic tension-type headaches.", "AZT given with ribavirin alleviates anemia.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Serotonin receptors have no effect on depression"], "hard_negatives": ["Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Bariatric surgery reduces resolution of diabetes.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Bariatric surgery has a deleterious impact on mental health.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Rates of hypertension in patients type 2 diabetes mellitus are similar to those in non-diabetic subjects.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "An N-formyl group on M3 molecules suppresss strong binding to the second position of the groove.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis."], "hard_negative": "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke."}
-{"query_id": "1301", "query_text": "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "negative": "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "negatives": ["Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Rapamycin accelerates aging in fruit flies.", "25% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma.", "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Falsified artemisinin family drugs with no active ingredient are generally safe.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Increased calcium levels activate transgultaminase activity."], "hard_negatives": ["Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Hypertension can be accurately diagnosed with ambulatory blood pressure monitoring.", "Bariatric surgery has a deleterious impact on mental health.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Incidence rates of cervical cancer have increased over time."], "hard_negative": "Thoracic aortic aneurysms affect 70-100 individuals per 100,000 people per year."}
-{"query_id": "1313", "query_text": "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "negative": "Low saturated fat diets have adverse effects on growth or development of infants.", "negatives": ["Low saturated fat diets have adverse effects on growth or development of infants.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Somatic missense mutations in NT5C2 are associated with relapse of acute lymphoblastic leukemia.", "Choice of specialty is not influenced by debt accrued from medical training.", "Colloid exposure has no effect on morbidity.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "The appearance of brown-like or beige cells primarily occurs in subcutaneous fat, not visceral fat."], "hard_negatives": ["Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "During the primary early antibody response activated B cells express low levels of EBI2.", "During the primary early antibody response activated B cells express high levels of EBI2.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Antibiotic induced alterations in the gut microbiome increase resistance against Clostridium difficile", "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Cytosolic proteins fail to bind to iron-responsive elements on mRNAs coding for TFRC1.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negative": "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus."}
-{"query_id": "1317", "query_text": "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "negative": "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "negatives": ["GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Serotonin receptors play a role in depression", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Side effects associated with antidepressants increases risk of mortality in postmenopausal women.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Distant CREs are more conserved among species.", "Delayed sleep phase disorder is associated with a dominant coding variation the core circadian clock gene CRY1.", "In the UK, drowning affects boys at a higher rate than girls.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia."], "hard_negatives": ["Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "During the primary early antibody response activated B cells express low levels of EBI2.", "IL-10 production by monocytes encourages CD4 + T cell response.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Immune complex triggered cell death slows down extracellular release of nuclear DNA.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negative": "Transient IFN-\u03b3 exposure leads to long-lived infammatory responses in cancer cells due to IFN-\u03b3 retention on the cell surface."}
-{"query_id": "1318", "query_text": "Transplanted human glial cells are incapable of differentiation within the host animal.", "negative": "Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "negatives": ["Polyploidization in megakaryocytes occurs in the presence of an aberrant mitosis.", "Vitamin D deficiency has no effect on the term of child delivery.", "CENP-B inhibits heterochromatin formation", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin.", "S-nitrosylated GAPDH physiologically transnitrosylates target nuclear proteins.", "Rapamycin accelerates aging in fruit flies.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures.", "Mitochondria are uninvolved in processes related to cell signaling.", "Deficiency of Tetraspanin-3 causes impaired stem cell-renewal and disease propagation.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury."], "hard_negatives": ["Transplanted human glial cells are incapable of differentiation within the host animal.", "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Osteocytes are not associated with G-CSF induced HSPC mobilization.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negative": "Transplanted human glial cells are incapable of differentiation within the host animal."}
-{"query_id": "1321", "query_text": "Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "negative": "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "negatives": ["The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Having a main partner lowers survival rates in HIV patients.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "Genetic deletion of JAM-A decreases gut permeability.", "There is no relation between lupus erythematosus and cardiovascular disease", "The minor G allele of FOXO3 represses IL-10.", "The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is nonessential for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1."], "hard_negatives": ["Transplanted human glial progenitor cells can form a neural network with host animals' neurons.", "Transplanted human glial cells are incapable of differentiation within the host animal.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex.", "There are four spatial channels in each hemifield of the auditory cortex of cats.", "Autologous transplantation of mesenchymal stem cells has worse graft function than induction therapy with anti-interleukin-2 receptor antibodies.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "The innate immune response is efficient at removing small numbers of parasites.", "Golli-deficient T-cells are dormant in initial clonal expansion.", "Gene expression can be highly variable across genetically identical cells."], "hard_negative": "Transplanted human glial progenitor cells can form a neural network with host animals' neurons."}
-{"query_id": "1326", "query_text": "Tuberculosis incidence is correlated with residential crowding in the UK.", "negative": "All phenotypes associated with reduced IIS require the gene daf-16.", "negatives": ["All phenotypes associated with reduced IIS require the gene daf-16.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "All six cathelicidins are located on chromosome two.", "\u03b21/Ketel is unable to bind microtubules.", "p16INK4A accumulation is encoded by CDKN2A.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Ginger is safe for mechanically ventilated patients.", "Falsified artemisinin family drugs with no active ingredient can be life-threatening."], "hard_negatives": ["Tuberculosis incidence is correlated with residential crowding in the UK.", "Malaria has a low vectorial capacity.", "Approximately 22,500 people are infected with human T-cell lymphotropic virus type 1 in the United Kingdom.", "In the UK, drowning affects boys at a higher rate than girls.", "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "Incidence of sepsis has remained stable between 2009-2014.", "Incidence rates of cervical cancer have increased over time.", "Ninety percent (90%) of kidney cancers in the UK are attributable to excess weight.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources.", "Infection of human T-cell lymphotropic virus type 1 is most frequent in individuals of European origin."], "hard_negative": "Tuberculosis incidence is correlated with residential crowding in the UK."}
-{"query_id": "1329", "query_text": "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "negative": "Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "negatives": ["Long chain polyunsaturated fatty acids supplementation is associated with lower rates of allergic sensitization  at 1 year.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Short British students are bullied less than control British students.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Side effects associated with antidepressants decrease risk of stroke.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Diminished ovarian reserve cannot be used in isolation as an indicator of infertility in a non-infertile population.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP."], "hard_negatives": ["Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Tuberculosis incidence is correlated with residential crowding in the UK.", "Radiographic verified pneumonia predictions are improved by the combination of physical examinations with C-reactive protein values."], "hard_negative": "Tuberculosis-induced granulomas express immune system protein signatures similar to those of the surrounding tissue."}
-{"query_id": "1338", "query_text": "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "negative": "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "negatives": ["Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "A country's Vaccine Alliance (GAVI) eligibility is associated with accelerated adoption of the Hub vaccine.", "Chikungunya virus (CHIKV) produced in mosquitos elicits rapid and long-lasting neutralizing antibodies in mice.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "DUSP4 downregulation activates the Ras-ERK pathway", "DUSP4 downregulation activates the Ras-ERK pathway", "Foxp3 displaces Foxo1 on chromatin", "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Medicare beneficiaries experienced a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006.", "LRBA controls CTLA - 4 expression."], "hard_negatives": ["Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "The actual sequences of CP-1 and CR-5 regions are evolutionarily conserved throughout most eukaryotes.", "Near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy.", "Genome size differences in rice are explained by LTR retrotransposon expansion.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers."], "hard_negative": "Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA."}
-{"query_id": "1343", "query_text": "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "negative": "Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "negatives": ["Carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more that non-carries.", "Oral ibandronate increases relative risk of new vertebral fractures and clinical vertebral fractures in women.", "Adult tissue-resident macrophages possess a self-renewing capacity.", "Obesity is determined in part by genetic factors.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Serotonin receptors have no effect on depression", "Rapamycin treatment raises G-CSF levels.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "Risedronate reduces risk of vertebral and non-vertebral fractures.", "The balance between F- and G-actin regulates the orientation of neuronal migration in the developing cerebral cortex."], "hard_negatives": ["Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches.", "Genomic instability in leukemia cells results from a decrease in reactive oxygen species from oncogene activation.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "Genomic instability in leukemia cells results from an increase in reactive oxygen species from oncogene activation.", "N348I mutations decrease resistance to zidovudine (AZT).", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "High methylation levels within individual DNA molecules correlates with high nucleosome occupancy across species.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses.", "A breast cancer patient's capacity to metabolize tamoxifen has no effect on treatment outcome."], "hard_negative": "Unlike transposon mutagenesis, chemical mutagenesis has the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches."}
-{"query_id": "1354", "query_text": "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "negative": "Foxp3 displaces Foxo1 on chromatin", "negatives": ["Foxp3 displaces Foxo1 on chromatin", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "BRCA 1 mutation carriers' risk of breast and ovarian cancer  is not influence by the location of the mutation.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Ly6C hi monocytes have a higher inflammatory capacity compared to their Ly6C lo counterparts.", "Autologous transplantation of mesenchymal stem cells has higher rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Lysine histone demethylase inhibitor JIB 04 is primarily active against KDM5A.", "Differentiated E2f-1, -2, -3 TKO cells in the intestine can exhibit apoptosis.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo."], "hard_negatives": ["V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation.", "N348I mutations decrease resistance to zidovudine (AZT).", "Increased calcium levels activate transgultaminase activity.", "PEP carboxylase enhances threonine production in E. coli.", "PEP carboxylase suppresses threonine production in E. coli.", "Increased calcium levels repress transgultaminase activity.", "Aspirin encourages the production of PGE2.", "mTORC2 inhibits xCT antiporter through phosphorylation.", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype."], "hard_negative": "V-9302 causes antitumor responses by increasing cell death and oxidative stress."}
-{"query_id": "1357", "query_text": "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "negative": "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "negatives": ["SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Obesity prolongs life expectancy.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Increased calcium levels repress transgultaminase activity.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress.", "Some signals for alternative polyadenylation sites are encoded in transposable elements.", "GEF-H1 activates RhoA in response to extracellular signal-regulated kinase activation.", "Nitric oxide (NO) can S- nitrosylate G protein-coupled receptor kinases (GRKs) to suppress their activity and block phosphorylation."], "hard_negatives": ["Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "The innate immune response is efficient at removing small numbers of parasites.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Low saturated fat diets have adverse effects on growth or development of infants.", "There is no relation between lupus erythematosus and cardiovascular disease", "Transcription factor EB prevents transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus.", "In rhesus macaques, daily subcutaneous injections of emtricitabine protect against rectally transmitted simian-human immunodeficiency virus.", "Funding the elimination of sporadic malaria cases is a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources."], "hard_negative": "Vaccinating the gastrointestinal tract is not effective in protecting rectal and vaginal mucosa."}
-{"query_id": "1358", "query_text": "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "negative": "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "negatives": ["The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "Participating in six months of physical activity impairs cognitive functioning.", "Physical injury activates transgultaminase activity.", "NLRP12 is a positive regulator of T-cell receptor activation.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "NAC encourages the generation of angiotensin-converting enzyme.", "The DESMOND program significantly improves biochemical outcomes.", "G-CSF prevents MDSCs from infiltrating tumors.", "The center of the granuloma in an immune cell induces an anti-inflammatory immune response.", "High levels of copeptin increase risk of diabetes."], "hard_negatives": ["Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "p16INK4A accumulation is encoded by CDKN2A.", "Localization of PIN1 in the Arabidopsis embryo requires VPS9a", "Deletion of \u03b1v\u03b28 results in a spontaneous inflammatory phenotype.", "Polyglutamine binding protein 1 (PQBP1) is the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is more cost-effective than the 10% risk threshold strategy.", "Conformational changes of the CD3 complex enable ITAM phosphorylation."], "hard_negative": "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367."}
-{"query_id": "1365", "query_text": "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "negative": "The minor G allele of FOXO3 represses IL-10.", "negatives": ["The minor G allele of FOXO3 represses IL-10.", "Rapamycin treatment raises G-CSF levels.", "There is no relation between lupus erythematosus and cardiovascular disease", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy.", "Lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells.", "C. elegans germlines lose their immortal character when nuclear RNAi is activated.", "Thigh-length graduated compression stockings (GCS) reduced deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke.", "Lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls.", "Having a main partner increases survival rates in HIV patients.", "Suboptimal nutrition is a leading cause of chronic disease"], "hard_negatives": ["Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population.", "Female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease.", "Bariatric surgery has a deleterious impact on mental health.", "Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are not required for recovery from spinal cord injury.", "Occipital activation levels are not correlated with auditory spatial performance in parietal regions of the brain.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Hypoglycemia decreases the risk of dementia.", "Cost effectiveness evaluations based on cRCT data do not represent patients in actual clinical practice.", "High cardiopulmonary fitness causes decreased mortality rate."], "hard_negative": "Verbal autopsy (VA) performed well in distinguishing between different injury categories in the elderly population."}
-{"query_id": "1369", "query_text": "Vitamin D deficiency has no effect on the term of child delivery.", "negative": "Major vault protein (MVP) functions to decrease tumor aggression.", "negatives": ["Major vault protein (MVP) functions to decrease tumor aggression.", "N348I mutations decrease resistance to zidovudine (AZT).", "Aspirin encourages the production of PGE2.", "Immune complex triggered cell death leads to extracellular release of oxidized mitochondrial DNA.", "Golli-deficient T-cells are hyper proliferative in initial clonal expansion.", "Intramembrane cleavage by SPP helps facilitate in the degradation of proteins with a complex membrane orientation.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "Physical injury activates transgultaminase activity.", "Pattern recognition receptors are transcripts determinant for resistance to Plasmodium infection.", "Primary cervical cytology screening with HPV detection is no more effective than conventional cytology at detecting severe cervical intraepithelial neoplasia."], "hard_negatives": ["Vitamin D deficiency has no effect on the term of child delivery.", "Asymptomatic bacteriuria has no effect on the risk for preterm delivery and low birth weight.", "Asymptomatic bacteriuria increases risk for preterm delivery and low birth weight.", "For every 1,000 children with cerebral palsy, 40-150 of them are premature or underweight at birth.", "Low saturated fat diets do not have adverse effects on growth or development of infants.", "Obesity decreases life expectancy.", "Obesity decreases life expectancy.", "Low saturated fat diets have adverse effects on growth or development of infants.", "Higher initial mortality is associated with antidepressant use.", "The number of unfertilized oocytes in mated hermaphrodites decreases with age."], "hard_negative": "Vitamin D deficiency has no effect on the term of child delivery."}
-{"query_id": "1377", "query_text": "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "negative": "10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "negatives": ["10-20% of people with severe mental disorder receive no treatment in low and middle income countries.", "Increased expression of Bcl2 is important for the maintenance and progression of tumors.", "Rapamycin treatment raises G-CSF levels.", "Roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Self-advocacy training is not effective at decreasing homelessness.", "PEP carboxylase enhances threonine production in E. coli.", "Autophagy deficiency in the liver protects from insulin resistance.", "Pseudoknots are evolutionarily conserved throughout most eukaryotes.", "Electromagnetic interference has no effect on Radio Frequency Identification (RFID) readability and reading distances.", "N348I mutations decrease resistance to zidovudine (AZT)."], "hard_negatives": ["Whole brain radiotherapy reduces the occurrence of new brain metastases.", "Hypoglycemia decreases the risk of dementia.", "Motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "50% of patients exposed to radiation have activated markers of myofibroblasts.", "Bariatric surgery has a deleterious impact on mental health.", "Athletes with or without a concussion have smaller volumes of hippocampal gray matter compared to healthy controls.", "Metastases have genomic aberrations different than those of the primary tumor.", "Side effects associated with antidepressants decrease risk of stroke.", "G-CSF prevents MDSCs from infiltrating tumors."], "hard_negative": "Whole brain radiotherapy reduces the occurrence of new brain metastases."}
-{"query_id": "1384", "query_text": "c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "negative": "Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "negatives": ["Decreases in region specific aerobic glycolysis in aged humans causes aging induced changes in brain glucose metabolism.", "Gastric lavage shows no benefit for acute paraquat poisoning.", "F4/80+ macrophages are located in the periosteum.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "F4/80+ macrophages are located in the periosteum.", "Adult tissue-resident macrophages are maintained independent of circulating monocytes.", "Synaptic activity impairs local synthesis of brain derived neurotrophic factor from postsynaptic dendrites.", "Monoclonal antibody targeting of N-cadherin promotes growth.", "Genetic deficiency of mast cells leads to increased weight gain in a mouse model of diet-induced obesity.", "Malaria has a low vectorial capacity."], "hard_negatives": ["c-MYC is important for maintaining pluripotent state of pluripotent stem cells.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "Mitochondria play a major role in calcium homeostasis.", "The periosteum consists of 2 layers: the inner layer on the periosteal surface with monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin; and the outer layer, consisting of collagens, blood vessels, and nerve endings.", "In a naive state, blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourages self-renewal of the mouse embryonic stem cells.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "The ring complexes of chromosomes in C. elegans oocytes are built in discrete layers."], "hard_negative": "c-MYC is important for maintaining pluripotent state of pluripotent stem cells."}
-{"query_id": "1388", "query_text": "mTORC2 inhibits xCT antiporter through phosphorylation.", "negative": "Distant CREs are more conserved among species.", "negatives": ["Distant CREs are more conserved among species.", "Combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors is ineffective at treating KRAS mutant tumors.", "High methylation levels within individual DNA molecules correlates with low nucleosome occupancy across species.", "Roughly 10% of women with chronic pelvic pain have no underlying pathology.", "F4/80+ macrophages are located in the periosteum.", "Patients with panic anxiety show increased CSF levels of hypocretin.", "Having a main partner lowers survival rates in HIV patients.", "Electrophysiological changes in motor neurons have been observed in patients with amyotrophic lateral sclerosis.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "mTORC2 inhibits xCT antiporter through phosphorylation."], "hard_negatives": ["mTORC2 inhibits xCT antiporter through phosphorylation.", "Deltex has been shown to interact with eIF3f, a DUB required for Notch activation process.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "The phosphorylation of Drp1 at S616 site inhibits its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII).", "The PDPN gene activates the C-type lectin receptor (CLEC-2).", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "IFI16 promotes STING phosphorylation and translocation, resulting in elevated activation of STING induced by cGAMP.", "NLRP12 is a positive regulator of T-cell receptor activation.", "The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces.", "V-9302 causes antitumor responses by increasing cell death and oxidative stress."], "hard_negative": "mTORC2 inhibits xCT antiporter through phosphorylation."}
-{"query_id": "1396", "query_text": "p16INK4A accumulation is encoded by CDKN2A.", "negative": "IL-10 production by monocytes encourages CD4 + T cell response.", "negatives": ["IL-10 production by monocytes encourages CD4 + T cell response.", "C-Met is involved in epithelial-mesenchymal transition in tumor cells.", "Somatic missense mutations in NT5C2 are not associated with relapse of acute lymphoblastic leukemia.", "Bronchial responsiveness is higher in the summer than in the winter.", "No strong relationship has been found with Pioglitazone use and increased risk for pancreatic cancer", "Obesity decreases life expectancy.", "S-nitrosylated GAPDH physiologically transnitrosylates DNA-activated protein kinase.", "The proportion of people with visual difficulty is two times higher in high-income countries than in low-income countries.", "Forkhead 0 (fox0) transcription factors are involved in cell cycle arrest.", "The 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy is less cost-effective than the 10% risk threshold strategy."], "hard_negatives": ["p16INK4A accumulation is encoded by CDKN2A.", "MUC1-C inhibits the NF-\u03baB p65 signaling pathway by interacting with I\u03baB kinase \u00df.", "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Conformational changes of the CD3 complex enable ITAM phosphorylation.", "NR5A2 is important in bile acid homeostasis in humans.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "Valproic acid (VPA) treatment allows reprogramming by the microRNA cluster miR302/367.", "Expression of MSX2 is induced 3 hours after the addition of BMP4, which occurs later than T and CDX2.", "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving cancer metastasis.", "Fibroblast growth factor 21 icreases vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels."], "hard_negative": "p16INK4A accumulation is encoded by CDKN2A."}
-{"query_id": "1399", "query_text": "p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "negative": "There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "negatives": ["There is a neuroprotective effect of Trpm4 inhibition in mice and rats.", "Tet enzymes activate microRNAs required for iPSC derivation.", "Long chain polyunsaturated fatty acids supplementation is associated with higher rates of allergic sensitization  at 1 year.", "Esrrb associates with BAF and Mbd3/NURD complexes.", "Short British students are bullied less than control British students.", "T regulatory cells (tTregs) lacking \u03b1v\u03b28 are unable to suppress pathogenic T-cell responses during active inflammation.", "In pediatric tissues, the dominant population of T cells are naive T cells emigrants from the thymus.", "Inside the body, falciparum parasites form agglomerates of infected cells to avoid spleen clearance.", "Mice are incapable of producing neutralizing antibodies in reponse to the Eilat virus (EILV) produced in mosquitos.", "Microarray results from culture-amplified mixtures of serotypes correlate well microarray results from uncultured mixtures."], "hard_negatives": ["p53 controls autophagy through the AMPK/mTOR-dependent pathway.", "Autophagy deficiency in the liver protects from insulin resistance.", "SOD1 integrates oxygen and glucose signals to repress cellular respiration.", "Phosphorylation of the ATM protein regulates DNA damage-induced neuronal death.", "MEK inhibitors are not effective in RAS-driven mouse models of cancer.", "Adipocytes in major adipose depots descend from cells with a history of Pdgfra expression.", "Autophagy increases in aged organisms.", "Inhibiting glucose-6-phospate dehydrogenase impairs lipogenesis by reactivating LKB1-AMPK signaling.", "p16INK4A accumulation is encoded by CDKN2A.", "APOE4 expression in iPSC-derived neurons results in increased tau phosphorylation."], "hard_negative": "p53 controls autophagy through the AMPK/mTOR-dependent pathway."}
-{"query_id": "1408", "query_text": "\u03b21/Ketel is unable to bind microtubules.", "negative": "Bronchial responsiveness is higher in the summer than in the winter.", "negatives": ["Bronchial responsiveness is higher in the summer than in the winter.", "Deficiency of Tetraspanin-3 causes improved stem cell-renewal and slows disease propagation.", "C. elegans germlines lose their immortal character when nuclear RNAi is disabled.", "Roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues.", "Hematopoietic progenitor cells are never susceptible to HIV-1 infection ex vivo.", "Whole brain radiotherapy reduces the occurrence of new brain metastases.", "The H3.3K36me3 histone reader protein ZMYND11 has a  higher binding affinity if G34R/V is mutated.", "NAC encourages the generation of angiotensin-converting enzyme.", "NAC encourages the generation of angiotensin-converting enzyme.", "Taking anti-depresents is associated with a increase in the A\u03b2 level in the brain of experimental animals."], "hard_negatives": ["\u03b21/Ketel is unable to bind microtubules.", "The tissue surrounding the granuloma in an immune cell induces an inflammatory immune response.", "Proteins synthesized at the growth cone are ubiquitinated at a lower rate than proteins from the cell body.", "During the primary early antibody response activated B cells express low levels of EBI2.", "During the primary early antibody response activated B cells express high levels of EBI2.", "Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB exhibit a strong affinity for phospholipids.", "Normal granulomas formed in the absence of TNF-\u2423 despite increased bacterial growth.", "Piezo1 channels are sensors for cell crowding in epithelial cells.", "Coordinated stabilization of kinetochore-microtubule attachments occurs at the prometaphase to metaphase transition.", "The binding orientation of the ML-SA1 activator at hTRPML2 is similar to the binding orientation of the ML-SA1 activator at hTRPML1."], "hard_negative": "\u03b21/Ketel is unable to bind microtubules."}