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import numpy as np
import pandas as pd
from tqdm import tqdm
from datetime import datetime
from sklearn.preprocessing import LabelEncoder
import pickle
import datetime
import os
import sys
from pathlib import Path
sys.path.append(os.path.dirname(os.path.abspath(__file__)) + './../..')
if not os.path.exists("./data/dict"):
os.makedirs("./data/dict")
if not os.path.exists("./data/csv"):
os.makedirs("./data/csv")
class Generator():
def __init__(self,task,cohort_output,if_mort,if_admn,if_los,feat_cond,feat_proc,feat_out,feat_chart,feat_med,impute,include_time=24,bucket=1,predW=6):
self.feat_cond,self.feat_proc,self.feat_out,self.feat_chart,self.feat_med = feat_cond,feat_proc,feat_out,feat_chart,feat_med
self.cohort_output=cohort_output
self.impute=impute
self.task = task
self.data = self.generate_adm()
if not os.path.exists("./data/dict/"+self.task):
os.makedirs("./data/dict/"+self.task)
print("[ READ COHORT ]")
self.generate_feat()
print("[ READ ALL FEATURES ]")
if if_mort:
self.mortality_length(include_time,predW)
print("[ PROCESSED TIME SERIES TO EQUAL LENGTH ]")
elif if_admn:
self.readmission_length(include_time)
print("[ PROCESSED TIME SERIES TO EQUAL LENGTH ]")
elif if_los:
self.los_length(include_time)
print("[ PROCESSED TIME SERIES TO EQUAL LENGTH ]")
self.smooth_meds(bucket)
print("[ SUCCESSFULLY SAVED DATA DICTIONARIES ]")
def generate_feat(self):
if(self.feat_cond):
print("[ ======READING DIAGNOSIS ]")
self.generate_cond()
if(self.feat_proc):
print("[ ======READING PROCEDURES ]")
self.generate_proc()
if(self.feat_out):
print("[ ======READING OUT EVENTS ]")
self.generate_out()
if(self.feat_chart):
print("[ ======READING CHART EVENTS ]")
self.generate_chart()
if(self.feat_med):
print("[ ======READING MEDICATIONS ]")
self.generate_meds()
def generate_adm(self):
data=pd.read_csv(f"./data/cohort/{self.cohort_output}.csv.gz", compression='gzip', header=0, index_col=None)
data['intime'] = pd.to_datetime(data['intime'])
data['outtime'] = pd.to_datetime(data['outtime'])
data['los']=pd.to_timedelta(data['outtime']-data['intime'],unit='h')
data['los']=data['los'].astype(str)
data[['days', 'dummy','hours']] = data['los'].str.split(' ', expand=True)
data[['hours','min','sec']] = data['hours'].str.split(':', expand=True)
data['los']=pd.to_numeric(data['days'])*24+pd.to_numeric(data['hours'])
data=data.drop(columns=['days', 'dummy','hours','min','sec'])
data=data[data['los']>0]
data['Age']=data['Age'].astype(int)
#print(data.head())
#print(data.shape)
return data
def generate_cond(self):
cond=pd.read_csv("./data/features/preproc_diag_icu.csv.gz", compression='gzip', header=0, index_col=None)
cond=cond[cond['stay_id'].isin(self.data['stay_id'])]
cond_per_adm = cond.groupby('stay_id').size().max()
self.cond, self.cond_per_adm = cond, cond_per_adm
def generate_proc(self):
proc=pd.read_csv("./data/features/preproc_proc_icu.csv.gz", compression='gzip', header=0, index_col=None)
proc=proc[proc['stay_id'].isin(self.data['stay_id'])]
proc[['start_days', 'dummy','start_hours']] = proc['event_time_from_admit'].str.split(' ', -1, expand=True)
proc[['start_hours','min','sec']] = proc['start_hours'].str.split(':', -1, expand=True)
proc['start_time']=pd.to_numeric(proc['start_days'])*24+pd.to_numeric(proc['start_hours'])
proc=proc.drop(columns=['start_days', 'dummy','start_hours','min','sec'])
proc=proc[proc['start_time']>=0]
###Remove where event time is after discharge time
proc=pd.merge(proc,self.data[['stay_id','los']],on='stay_id',how='left')
proc['sanity']=proc['los']-proc['start_time']
proc=proc[proc['sanity']>0]
del proc['sanity']
self.proc=proc
def generate_out(self):
out=pd.read_csv("./data/features/preproc_out_icu.csv.gz", compression='gzip', header=0, index_col=None)
out=out[out['stay_id'].isin(self.data['stay_id'])]
out[['start_days', 'dummy','start_hours']] = out['event_time_from_admit'].str.split(' ', -1, expand=True)
out[['start_hours','min','sec']] = out['start_hours'].str.split(':', -1, expand=True)
out['start_time']=pd.to_numeric(out['start_days'])*24+pd.to_numeric(out['start_hours'])
out=out.drop(columns=['start_days', 'dummy','start_hours','min','sec'])
out=out[out['start_time']>=0]
###Remove where event time is after discharge time
out=pd.merge(out,self.data[['stay_id','los']],on='stay_id',how='left')
out['sanity']=out['los']-out['start_time']
out=out[out['sanity']>0]
del out['sanity']
self.out=out
def generate_chart(self):
chunksize = 5000000
final=pd.DataFrame()
for chart in tqdm(pd.read_csv("./data/features/preproc_chart_icu.csv.gz", compression='gzip', header=0, index_col=None,chunksize=chunksize)):
chart=chart[chart['stay_id'].isin(self.data['stay_id'])]
chart[['start_days', 'dummy','start_hours']] = chart['event_time_from_admit'].str.split(' ', -1, expand=True)
chart[['start_hours','min','sec']] = chart['start_hours'].str.split(':', -1, expand=True)
chart['start_time']=pd.to_numeric(chart['start_days'])*24+pd.to_numeric(chart['start_hours'])
chart=chart.drop(columns=['start_days', 'dummy','start_hours','min','sec','event_time_from_admit'])
chart=chart[chart['start_time']>=0]
###Remove where event time is after discharge time
chart=pd.merge(chart,self.data[['stay_id','los']],on='stay_id',how='left')
chart['sanity']=chart['los']-chart['start_time']
chart=chart[chart['sanity']>0]
del chart['sanity']
del chart['los']
if final.empty:
final=chart
else:
final=final.append(chart, ignore_index=True)
self.chart=final
def generate_meds(self):
meds=pd.read_csv("./data/features/preproc_med_icu.csv.gz", compression='gzip', header=0, index_col=None)
meds[['start_days', 'dummy','start_hours']] = meds['start_hours_from_admit'].str.split(' ', -1, expand=True)
meds[['start_hours','min','sec']] = meds['start_hours'].str.split(':', -1, expand=True)
meds['start_time']=pd.to_numeric(meds['start_days'])*24+pd.to_numeric(meds['start_hours'])
meds[['start_days', 'dummy','start_hours']] = meds['stop_hours_from_admit'].str.split(' ', -1, expand=True)
meds[['start_hours','min','sec']] = meds['start_hours'].str.split(':', -1, expand=True)
meds['stop_time']=pd.to_numeric(meds['start_days'])*24+pd.to_numeric(meds['start_hours'])
meds=meds.drop(columns=['start_days', 'dummy','start_hours','min','sec'])
#####Sanity check
meds['sanity']=meds['stop_time']-meds['start_time']
meds=meds[meds['sanity']>0]
del meds['sanity']
#####Select hadm_id as in main file
meds=meds[meds['stay_id'].isin(self.data['stay_id'])]
meds=pd.merge(meds,self.data[['stay_id','los']],on='stay_id',how='left')
#####Remove where start time is after end of visit
meds['sanity']=meds['los']-meds['start_time']
meds=meds[meds['sanity']>0]
del meds['sanity']
####Any stop_time after end of visit is set at end of visit
meds.loc[meds['stop_time'] > meds['los'],'stop_time']=meds.loc[meds['stop_time'] > meds['los'],'los']
del meds['los']
meds['rate']=meds['rate'].apply(pd.to_numeric, errors='coerce')
meds['amount']=meds['amount'].apply(pd.to_numeric, errors='coerce')
self.meds=meds
def mortality_length(self,include_time,predW):
print("include_time",include_time)
self.los=include_time
self.data=self.data[(self.data['los']>=include_time+predW)]
self.hids=self.data['stay_id'].unique()
if(self.feat_cond):
self.cond=self.cond[self.cond['stay_id'].isin(self.data['stay_id'])]
self.data['los']=include_time
####Make equal length input time series and remove data for pred window if needed
###MEDS
if(self.feat_med):
self.meds=self.meds[self.meds['stay_id'].isin(self.data['stay_id'])]
self.meds=self.meds[self.meds['start_time']<=include_time]
self.meds.loc[self.meds.stop_time >include_time, 'stop_time']=include_time
###PROCS
if(self.feat_proc):
self.proc=self.proc[self.proc['stay_id'].isin(self.data['stay_id'])]
self.proc=self.proc[self.proc['start_time']<=include_time]
###OUT
if(self.feat_out):
self.out=self.out[self.out['stay_id'].isin(self.data['stay_id'])]
self.out=self.out[self.out['start_time']<=include_time]
###CHART
if(self.feat_chart):
self.chart=self.chart[self.chart['stay_id'].isin(self.data['stay_id'])]
self.chart=self.chart[self.chart['start_time']<=include_time]
#self.los=include_time
def los_length(self,include_time):
print("include_time",include_time)
self.los=include_time
self.data=self.data[(self.data['los']>=include_time)]
self.hids=self.data['stay_id'].unique()
if(self.feat_cond):
self.cond=self.cond[self.cond['stay_id'].isin(self.data['stay_id'])]
self.data['los']=include_time
####Make equal length input time series and remove data for pred window if needed
###MEDS
if(self.feat_med):
self.meds=self.meds[self.meds['stay_id'].isin(self.data['stay_id'])]
self.meds=self.meds[self.meds['start_time']<=include_time]
self.meds.loc[self.meds.stop_time >include_time, 'stop_time']=include_time
###PROCS
if(self.feat_proc):
self.proc=self.proc[self.proc['stay_id'].isin(self.data['stay_id'])]
self.proc=self.proc[self.proc['start_time']<=include_time]
###OUT
if(self.feat_out):
self.out=self.out[self.out['stay_id'].isin(self.data['stay_id'])]
self.out=self.out[self.out['start_time']<=include_time]
###CHART
if(self.feat_chart):
self.chart=self.chart[self.chart['stay_id'].isin(self.data['stay_id'])]
self.chart=self.chart[self.chart['start_time']<=include_time]
def readmission_length(self,include_time):
self.los=include_time
self.data=self.data[(self.data['los']>=include_time)]
self.hids=self.data['stay_id'].unique()
if(self.feat_cond):
self.cond=self.cond[self.cond['stay_id'].isin(self.data['stay_id'])]
self.data['select_time']=self.data['los']-include_time
self.data['los']=include_time
####Make equal length input time series and remove data for pred window if needed
###MEDS
if(self.feat_med):
self.meds=self.meds[self.meds['stay_id'].isin(self.data['stay_id'])]
self.meds=pd.merge(self.meds,self.data[['stay_id','select_time']],on='stay_id',how='left')
self.meds['stop_time']=self.meds['stop_time']-self.meds['select_time']
self.meds['start_time']=self.meds['start_time']-self.meds['select_time']
self.meds=self.meds[self.meds['stop_time']>=0]
self.meds.loc[self.meds.start_time <0, 'start_time']=0
###PROCS
if(self.feat_proc):
self.proc=self.proc[self.proc['stay_id'].isin(self.data['stay_id'])]
self.proc=pd.merge(self.proc,self.data[['stay_id','select_time']],on='stay_id',how='left')
self.proc['start_time']=self.proc['start_time']-self.proc['select_time']
self.proc=self.proc[self.proc['start_time']>=0]
###OUT
if(self.feat_out):
self.out=self.out[self.out['stay_id'].isin(self.data['stay_id'])]
self.out=pd.merge(self.out,self.data[['stay_id','select_time']],on='stay_id',how='left')
self.out['start_time']=self.out['start_time']-self.out['select_time']
self.out=self.out[self.out['start_time']>=0]
###CHART
if(self.feat_chart):
self.chart=self.chart[self.chart['stay_id'].isin(self.data['stay_id'])]
self.chart=pd.merge(self.chart,self.data[['stay_id','select_time']],on='stay_id',how='left')
self.chart['start_time']=self.chart['start_time']-self.chart['select_time']
self.chart=self.chart[self.chart['start_time']>=0]
def smooth_meds(self,bucket):
final_meds=pd.DataFrame()
final_proc=pd.DataFrame()
final_out=pd.DataFrame()
final_chart=pd.DataFrame()
if(self.feat_med):
self.meds=self.meds.sort_values(by=['start_time'])
if(self.feat_proc):
self.proc=self.proc.sort_values(by=['start_time'])
if(self.feat_out):
self.out=self.out.sort_values(by=['start_time'])
if(self.feat_chart):
self.chart=self.chart.sort_values(by=['start_time'])
t=0
for i in tqdm(range(0,self.los,bucket)):
###MEDS
if(self.feat_med):
sub_meds=self.meds[(self.meds['start_time']>=i) & (self.meds['start_time']<i+bucket)].groupby(['stay_id','itemid','orderid']).agg({'stop_time':'max','subject_id':'max','rate':np.nanmean,'amount':np.nanmean})
sub_meds=sub_meds.reset_index()
sub_meds['start_time']=t
sub_meds['stop_time']=sub_meds['stop_time']/bucket
if final_meds.empty:
final_meds=sub_meds
else:
final_meds=final_meds.append(sub_meds)
###PROC
if(self.feat_proc):
sub_proc=self.proc[(self.proc['start_time']>=i) & (self.proc['start_time']<i+bucket)].groupby(['stay_id','itemid']).agg({'subject_id':'max'})
sub_proc=sub_proc.reset_index()
sub_proc['start_time']=t
if final_proc.empty:
final_proc=sub_proc
else:
final_proc=final_proc.append(sub_proc)
###OUT
if(self.feat_out):
sub_out=self.out[(self.out['start_time']>=i) & (self.out['start_time']<i+bucket)].groupby(['stay_id','itemid']).agg({'subject_id':'max'})
sub_out=sub_out.reset_index()
sub_out['start_time']=t
if final_out.empty:
final_out=sub_out
else:
final_out=final_out.append(sub_out)
###CHART
if(self.feat_chart):
sub_chart=self.chart[(self.chart['start_time']>=i) & (self.chart['start_time']<i+bucket)].groupby(['stay_id','itemid']).agg({'valuenum':np.nanmean})
sub_chart=sub_chart.reset_index()
sub_chart['start_time']=t
if final_chart.empty:
final_chart=sub_chart
else:
final_chart=final_chart.append(sub_chart)
t=t+1
print("bucket",bucket)
los=int(self.los/bucket)
###MEDS
if(self.feat_med):
f2_meds=final_meds.groupby(['stay_id','itemid','orderid']).size()
self.med_per_adm=f2_meds.groupby('stay_id').sum().reset_index()[0].max()
self.medlength_per_adm=final_meds.groupby('stay_id').size().max()
###PROC
if(self.feat_proc):
f2_proc=final_proc.groupby(['stay_id','itemid']).size()
self.proc_per_adm=f2_proc.groupby('stay_id').sum().reset_index()[0].max()
self.proclength_per_adm=final_proc.groupby('stay_id').size().max()
###OUT
if(self.feat_out):
f2_out=final_out.groupby(['stay_id','itemid']).size()
self.out_per_adm=f2_out.groupby('stay_id').sum().reset_index()[0].max()
self.outlength_per_adm=final_out.groupby('stay_id').size().max()
###chart
if(self.feat_chart):
f2_chart=final_chart.groupby(['stay_id','itemid']).size()
self.chart_per_adm=f2_chart.groupby('stay_id').sum().reset_index()[0].max()
self.chartlength_per_adm=final_chart.groupby('stay_id').size().max()
print("[ PROCESSED TIME SERIES TO EQUAL TIME INTERVAL ]")
###CREATE DICT
# if(self.feat_chart):
# self.create_chartDict(final_chart,los)
# else:
self.create_Dict(final_meds,final_proc,final_out,final_chart,los)
def create_Dict(self,meds,proc,out,chart,los):
dataDic={}
for hid in self.hids:
grp=self.data[self.data['stay_id']==hid]
dataDic[hid]={'Cond':{},'Proc':{},'Med':{},'Out':{},'Chart':{},'ethnicity':grp['ethnicity'].iloc[0],'age':int(grp['Age']),'gender':grp['gender'].iloc[0],'label':int(grp['label'])}
for hid in tqdm(self.hids):
grp=self.data[self.data['stay_id']==hid]
###MEDS
if(self.feat_med):
feat=meds['itemid'].unique()
df2=meds[meds['stay_id']==hid]
if df2.shape[0]==0:
amount=pd.DataFrame(np.zeros([los,len(feat)]),columns=feat)
amount=amount.fillna(0)
amount.columns=pd.MultiIndex.from_product([["MEDS"], amount.columns])
else:
rate=df2.pivot_table(index='start_time',columns='itemid',values='rate')
#print(rate)
amount=df2.pivot_table(index='start_time',columns='itemid',values='amount')
df2=df2.pivot_table(index='start_time',columns='itemid',values='stop_time')
#print(df2.shape)
add_indices = pd.Index(range(los)).difference(df2.index)
add_df = pd.DataFrame(index=add_indices, columns=df2.columns).fillna(np.nan)
df2=pd.concat([df2, add_df])
df2=df2.sort_index()
df2=df2.ffill()
df2=df2.fillna(0)
rate=pd.concat([rate, add_df])
rate=rate.sort_index()
rate=rate.ffill()
rate=rate.fillna(-1)
amount=pd.concat([amount, add_df])
amount=amount.sort_index()
amount=amount.ffill()
amount=amount.fillna(-1)
#print(df2.head())
df2.iloc[:,0:]=df2.iloc[:,0:].sub(df2.index,0)
df2[df2>0]=1
df2[df2<0]=0
rate.iloc[:,0:]=df2.iloc[:,0:]*rate.iloc[:,0:]
amount.iloc[:,0:]=df2.iloc[:,0:]*amount.iloc[:,0:]
#print(df2.head())
dataDic[hid]['Med']['signal']=df2.iloc[:,0:].to_dict(orient="list")
dataDic[hid]['Med']['rate']=rate.iloc[:,0:].to_dict(orient="list")
dataDic[hid]['Med']['amount']=amount.iloc[:,0:].to_dict(orient="list")
###PROCS
if(self.feat_proc):
feat=proc['itemid'].unique()
df2=proc[proc['stay_id']==hid]
if df2.shape[0]==0:
df2=pd.DataFrame(np.zeros([los,len(feat)]),columns=feat)
df2=df2.fillna(0)
df2.columns=pd.MultiIndex.from_product([["PROC"], df2.columns])
else:
df2['val']=1
#print(df2)
df2=df2.pivot_table(index='start_time',columns='itemid',values='val')
#print(df2.shape)
add_indices = pd.Index(range(los)).difference(df2.index)
add_df = pd.DataFrame(index=add_indices, columns=df2.columns).fillna(np.nan)
df2=pd.concat([df2, add_df])
df2=df2.sort_index()
df2=df2.fillna(0)
df2[df2>0]=1
#print(df2.head())
dataDic[hid]['Proc']=df2.to_dict(orient="list")
###OUT
if(self.feat_out):
feat=out['itemid'].unique()
df2=out[out['stay_id']==hid]
if df2.shape[0]==0:
df2=pd.DataFrame(np.zeros([los,len(feat)]),columns=feat)
df2=df2.fillna(0)
df2.columns=pd.MultiIndex.from_product([["OUT"], df2.columns])
else:
df2['val']=1
df2=df2.pivot_table(index='start_time',columns='itemid',values='val')
#print(df2.shape)
add_indices = pd.Index(range(los)).difference(df2.index)
add_df = pd.DataFrame(index=add_indices, columns=df2.columns).fillna(np.nan)
df2=pd.concat([df2, add_df])
df2=df2.sort_index()
df2=df2.fillna(0)
df2[df2>0]=1
#print(df2.head())
dataDic[hid]['Out']=df2.to_dict(orient="list")
###CHART
if(self.feat_chart):
feat=chart['itemid'].unique()
df2=chart[chart['stay_id']==hid]
if df2.shape[0]==0:
val=pd.DataFrame(np.zeros([los,len(feat)]),columns=feat)
val=val.fillna(0)
val.columns=pd.MultiIndex.from_product([["CHART"], val.columns])
else:
val=df2.pivot_table(index='start_time',columns='itemid',values='valuenum')
df2['val']=1
df2=df2.pivot_table(index='start_time',columns='itemid',values='val')
#print(df2.shape)
add_indices = pd.Index(range(los)).difference(df2.index)
add_df = pd.DataFrame(index=add_indices, columns=df2.columns).fillna(np.nan)
df2=pd.concat([df2, add_df])
df2=df2.sort_index()
df2=df2.fillna(0)
val=pd.concat([val, add_df])
val=val.sort_index()
if self.impute=='Mean':
val=val.ffill()
val=val.bfill()
val=val.fillna(val.mean())
elif self.impute=='Median':
val=val.ffill()
val=val.bfill()
val=val.fillna(val.median())
val=val.fillna(0)
df2[df2>0]=1
df2[df2<0]=0
#print(df2.head())
dataDic[hid]['Chart']['signal']=df2.iloc[:,0:].to_dict(orient="list")
dataDic[hid]['Chart']['val']=val.iloc[:,0:].to_dict(orient="list")
##########COND#########
if(self.feat_cond):
feat=self.cond['new_icd_code'].unique()
grp=self.cond[self.cond['stay_id']==hid]
if(grp.shape[0]==0):
dataDic[hid]['Cond']={'fids':list(['<PAD>'])}
else:
dataDic[hid]['Cond']={'fids':list(grp['new_icd_code'])}
######SAVE DICTIONARIES##############
metaDic={'Cond':{},'Proc':{},'Med':{},'Out':{},'Chart':{},'LOS':{}}
metaDic['LOS']=los
with open("./data/dict/"+self.task+"/dataDic", 'wb') as fp:
pickle.dump(dataDic, fp)
with open("./data/dict/"+self.task+"/hadmDic", 'wb') as fp:
pickle.dump(self.hids, fp)
with open("./data/dict/"+self.task+"/ethVocab", 'wb') as fp:
pickle.dump(list(self.data['ethnicity'].unique()), fp)
self.eth_vocab = self.data['ethnicity'].nunique()
with open("./data/dict/"+self.task+"/ageVocab", 'wb') as fp:
pickle.dump(list(self.data['Age'].unique()), fp)
self.age_vocab = self.data['Age'].nunique()
with open("./data/dict/"+self.task+"/insVocab", 'wb') as fp:
pickle.dump(list(self.data['insurance'].unique()), fp)
self.ins_vocab = self.data['insurance'].nunique()
if(self.feat_med):
with open("./data/dict/"+self.task+"/medVocab", 'wb') as fp:
pickle.dump(list(meds['itemid'].unique()), fp)
self.med_vocab = meds['itemid'].nunique()
metaDic['Med']=self.med_per_adm
if(self.feat_out):
with open("./data/dict/"+self.task+"/outVocab", 'wb') as fp:
pickle.dump(list(out['itemid'].unique()), fp)
self.out_vocab = out['itemid'].nunique()
metaDic['Out']=self.out_per_adm
if(self.feat_chart):
with open("./data/dict/"+self.task+"/chartVocab", 'wb') as fp:
pickle.dump(list(chart['itemid'].unique()), fp)
self.chart_vocab = chart['itemid'].nunique()
metaDic['Chart']=self.chart_per_adm
if(self.feat_cond):
with open("./data/dict/"+self.task+"/condVocab", 'wb') as fp:
pickle.dump(list(self.cond['new_icd_code'].unique()), fp)
self.cond_vocab = self.cond['new_icd_code'].nunique()
metaDic['Cond']=self.cond_per_adm
if(self.feat_proc):
with open("./data/dict/"+self.task+"/procVocab", 'wb') as fp:
pickle.dump(list(proc['itemid'].unique()), fp)
self.proc_vocab = proc['itemid'].nunique()
metaDic['Proc']=self.proc_per_adm
with open("./data/dict/"+self.task+"/metaDic", 'wb') as fp:
pickle.dump(metaDic, fp) |