Unnamed: 0
int64 0
180k
| text
stringlengths 2
1.45k
| id
int64 0
180k
| label
int64 0
4
|
|---|---|---|---|
179,500 | Treatment response was defined as a > 50 % reduction in GETS scores . | 179,500 | 1 |
179,501 | All patients entering this study recorded side effects at days 1 , 8 , 15 , 22 and 29 using a visual analogue scale . | 179,501 | 1 |
179,502 | Thirty patients completed the study . | 179,502 | 2 |
179,503 | After 4 wk of treatment , the AMT group had a greater response than the conventional group ( 75 % vs 35.7 % , P = 0.004 ) . | 179,503 | 2 |
179,504 | At day 3 , the AMT group showed significantly more improvement than the Conventional group in GETS score ( 3.69 1.14 vs 5.64 1.28 , P = 0.000 ) . | 179,504 | 2 |
179,505 | After 4 wk of treatment , the AMT group showed significantly greater improvement in GETS score and sleep quality than the Conventional group ( 1.25 1.84 vs 3.79 2.33 , 4.19 2.07 vs 8.5 4.97 ; P < 0.01 for both ) . | 179,505 | 2 |
179,506 | Additionally , the AMT group was more likely than the Conventional group to experience improvement in the SF-36 , including general health , vitality , social functioning and mental health ( P = 0.044 , 0.024 , 0.049 and 0.005 ) . | 179,506 | 2 |
179,507 | Dry mouth , sleepiness , dizziness and constipation were the most common side effects . | 179,507 | 2 |
179,508 | Low-dose AMT is well tolerated and can significantly improve patient symptoms , sleep and quality of life . | 179,508 | 3 |
179,509 | Thus , low-dose AMT may be an effective treatment for globus pharyngeus . | 179,509 | 3 |
179,510 | Up to now , all tested Ebola virus vaccines have been based on the virus strain from the Zaire outbreak in 1976 . | 179,510 | 4 |
179,511 | We aimed to assess the safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine expressing the glycoprotein of the 2014 epidemic strain . | 179,511 | 4 |
179,512 | We did this randomised , double-blind , placebo-controlled , phase 1 clinical trial at one site in Taizhou County , Jiangsu Province , China . | 179,512 | 1 |
179,513 | Healthy adults ( aged 18-60 years ) were sequentially enrolled and randomly assigned ( 2:1 ) , by computer-generated block randomisation ( block size of six ) , to receive placebo , low-dose adenovirus type-5 vector-based Ebola vaccine , or high-dose vaccine . | 179,513 | 1 |
179,514 | Randomisation was pre-stratified by dose group . | 179,514 | 1 |
179,515 | All participants , investigators , and laboratory staff were masked to treatment allocation . | 179,515 | 1 |
179,516 | The primary safety endpoint was occurrence of solicited adverse reactions within 7 days of vaccination . | 179,516 | 1 |
179,517 | The primary immunogenicity endpoints were glycoprotein-specific antibody titres and T-cell responses at day 28 after the vaccination . | 179,517 | 1 |
179,518 | Analysis was by intention to treat . | 179,518 | 1 |
179,519 | The study is registered with ClinicalTrials.gov , number NCT02326194 . | 179,519 | 1 |
179,520 | Between Dec 28 , 2014 , and Jan 9 , 2015 , 120 participants were enrolled and randomly assigned to receive placebo ( n = 40 ) , low-dose vaccine ( n = 40 ) , or high-dose vaccine . | 179,520 | 2 |
179,521 | Participants were followed up for 28 days . | 179,521 | 2 |
179,522 | Overall , 82 ( 68 % ) participants reported at least one solicited adverse reaction within 7 days of vaccination ( n = 19 in the placebo group vs n = 27 in the low-dose group vs n = 36 in the high-dose group ; p = 00002 ) . | 179,522 | 2 |
179,523 | The most common reaction was mild pain at the injection site , which was reported in eight ( 20 % ) participants in the placebo group , 14 ( 35 % ) participants in the low-dose group , and 29 ( 73 % ) participants in the high-dose vaccine group ( p < 00001 ) . | 179,523 | 2 |
179,524 | We recorded no statistical differences in other adverse reactions and laboratory tests across groups . | 179,524 | 2 |
179,525 | Glycoprotein-specific antibody titres were significantly increased in participants in the low-dose and high-dose vaccine groups at both day 14 ( geometric mean titre 4214 [ 95 % CI 2497-7113 ] and 8205 [ 5989-11240 ] , respectively ; p < 00001 ) and day 28 ( 6827 [ 4243-10985 ] and 13057 [ 9701-17572 ] , respectively ; p < 00001 ) . | 179,525 | 2 |
179,526 | T-cell responses peaked at day 14 at a median of 4650 spot-forming cells ( IQR 1800-12025 ) in participants in the low-dose group and 7650 cells ( 4000-14600 ) in those in the high-dose group . | 179,526 | 2 |
179,527 | 21 ( 18 % ) participants had mild fever ( n = 9 in the placebo group , n = 6 in the low-dose group , and n = 6 in the high-dose group ) . | 179,527 | 2 |
179,528 | No serious adverse events were recorded . | 179,528 | 2 |
179,529 | Our findings show that the high-dose vaccine is safe and robustly immunogenic . | 179,529 | 3 |
179,530 | One shot of the high-dose vaccine could mount glycoprotein-specific humoral and T-cell response against Ebola virus in 14 days . | 179,530 | 3 |
179,531 | China National Science and Technology , Beijing Institute of Biotechnology , and Tianjin CanSino Biotechnology . | 179,531 | 4 |
179,532 | To evaluate the thermal antinociceptive effects and duration of action of buprenorphine hydrochloride after IM administration to American kestrels ( Falco sparverius ) . | 179,532 | 0 |
179,533 | 12 healthy 3-year-old American kestrels . | 179,533 | 1 |
179,534 | Buprenorphine hydrochloride ( 0.1 , 0.3 , and 0.6 mg/kg ) and a control treatment ( saline [ 0.9 % NaCl ] solution ) were administered IM in a randomized crossover experimental design . | 179,534 | 1 |
179,535 | Foot withdrawal response to a thermal stimulus was determined 1 hour before ( baseline ) and 1.5 , 3 , and 6 hours after treatment administration . | 179,535 | 1 |
179,536 | Agitation-sedation scores were determined 3 to 5 minutes before each thermal stimulus . | 179,536 | 1 |
179,537 | Adverse effects were monitored for 6 hours after treatment administration . | 179,537 | 1 |
179,538 | Buprenorphine hydrochloride at 0.1 , 0.3 , and 0.6 mg/kg , IM , increased thermal threshold for 6 hours , compared with the response for the control treatment . | 179,538 | 2 |
179,539 | There were no significant differences among buprenorphine treatments . | 179,539 | 2 |
179,540 | A mild sedative effect was detected at a dose of 0.6 mg of buprenorphine/kg . | 179,540 | 2 |
179,541 | At the doses tested , buprenorphine hydrochloride resulted in thermal antinociception in American kestrels for at least 6 hours , which suggested that buprenorphine has analgesic effects in this species . | 179,541 | 3 |
179,542 | Further studies with longer evaluation periods and additional forms of noxious stimuli , formulations , dosages , and routes of administration are needed to fully evaluate the analgesic effects of buprenorphine in American kestrels . | 179,542 | 3 |
179,543 | Patellofemoral pain syndrome ( PFPS ) is a common musculoskeletal condition , particularly among women . | 179,543 | 4 |
179,544 | Patients with PFPS usually experience weakness in the gluteal muscles , as well as pain and impaired motor control during activities of daily living . | 179,544 | 4 |
179,545 | Strengthening the hip muscles is an effective way of treating this disorder . | 179,545 | 4 |
179,546 | Neuromuscular training has also been identified as a therapeutic tool , although the benefits of this intervention in patients with PFPS patients remain inconclusive . | 179,546 | 4 |
179,547 | This is a protocol of randomized controlled trial with a blind assessor . | 179,547 | 1 |
179,548 | Thirty-four women with a clinical diagnosis of PFPS participated . | 179,548 | 1 |
179,549 | These participants were allocated into two groups ( experimental and control ) . | 179,549 | 1 |
179,550 | The experimental group performed twelve sessions to strengthen the knee extensors , hip abductor and lateral rotator muscles in association with neuromuscular training of the trunk and lower extremities . | 179,550 | 1 |
179,551 | The control group performed the same number of sessions to strengthen the muscles of the hip and knee . | 179,551 | 1 |
179,552 | The primary outcome was functional capacity ( Anterior Knee Pain Scale - AKPS ) at 4weeks . | 179,552 | 1 |
179,553 | Pain intensity , muscle strength and kinematic changes were also measured during the step down test after four weeks of intervention . | 179,553 | 1 |
179,554 | Follow up assessments were conducted after three and six months to assess functional capacity and pain . | 179,554 | 1 |
179,555 | The effects of the treatment ( i.e. between-group differences ) were calculated using mixed linear models . | 179,555 | 1 |
179,556 | The present study was initiated on the 1st of April 2013 and is currently in progress . | 179,556 | 3 |
179,557 | The results of this study may introduce another effective technique of conservative treatment and could guide physical therapists in the clinical decision-making process for women with PFPS . | 179,557 | 3 |
179,558 | Current Controlled Trials NCT01804608 . | 179,558 | 4 |
179,559 | The objective of this study was to evaluate the effect of nasal packing , septal suture technique and vacuum sealing drainage ( VSD ) after septoplasty . | 179,559 | 0 |
179,560 | Ninety patients of nasal septal deviation in Combination with outfracture of the inferior turbinates who had received septoplasty were selected in this study . | 179,560 | 1 |
179,561 | The patients were allocated into three groups , with thirty in each : for packing group , marcel materials were used for nasal packing after septoplasty ; for suturing group , septal suture technique was performed after septoplasty ; for VSD group , one drainage tube was used for negative pressure sucking after septoplasty without nasal packing . | 179,561 | 1 |
179,562 | Postoperative signs and symptoms were compared between three groups . | 179,562 | 1 |
179,563 | The comfort degree assessment included headache and nasal obstruction were evaluated by using visual analogue scale ( VAS ) at the 12th hour and 24 hour after operation . | 179,563 | 1 |
179,564 | The edema in nasal cavity , hemorrhage . | 179,564 | 1 |
179,565 | abscess , adhesive and healing rates after operation were compared among three groups . | 179,565 | 1 |
179,566 | The VAS score of headache and nasal obstruction and the severity of patient 's conditions were significantly less in septal suture group and VSD group than that in packing group at the 12th and 24th hour after operation . | 179,566 | 2 |
179,567 | The mucosa edema of nasal cavity was significantly slighter in septal suture group and VSD group than that in packing group at the third day after operation . | 179,567 | 2 |
179,568 | The healing rates and number of complications are better in septal suture group and VSD group than those in packing group at the 7th day after operation . | 179,568 | 2 |
179,569 | There were no hemorrhage or abscess in VSD group . | 179,569 | 2 |
179,570 | Septal suture technique and VSD after septoplasty can significantly relieve the distress of patients and reduce the healing time of mucosa in nasal cavity without increasing the risk of complications . | 179,570 | 3 |
179,571 | To investigate baseline predictors of month 24 best-corrected visual acuity ( BCVA ) and central foveal thickness ( CFT ) in patients with diabetic macular edema ( DME ) treated monthly with ranibizumab or sham . | 179,571 | 0 |
179,572 | Post hoc analysis of DME patients in 2 identical phase 3 studies . | 179,572 | 1 |
179,573 | Patients randomized to ranibizumab ( n = 502 ) or sham ( n = 257 ) . | 179,573 | 1 |
179,574 | Multivariate regression on predictors with P < 0.20 in univariate logistic regression using backward selection to retain predictors with P < 0.05 . | 179,574 | 1 |
179,575 | Patient characteristics correlating with month 24 BCVA in Early Treatment Diabetic Retinopathy Study letter score 70 ( 20/40 ) or 50 ( 20/100 ) , gain or loss from baseline BCVA of 15 , or CFT 250 m. | 179,575 | 1 |
179,576 | Baseline predictors of BCVA 20/40 in ranibizumab-treated patients were good BCVA , submacular fluid , no cardiovascular disease , no scatter photocoagulation , and male gender , whereas in sham-treated patients , they were mild increase in CFT , presence of hard exudates in center subfield , and absence of renal disease . | 179,576 | 2 |
179,577 | Predictors of improvement in BCVA letter score 15 in ranibizumab-treated patients were poor BCVA , submacular fluid , young age , and short diabetes duration , and those in sham-treated patients were poor BCVA , young age , and mild increase in CFT . | 179,577 | 2 |
179,578 | Predictors of resolution of edema ( CFT 250 m ) in ranibizumab-treated patients were mild foveal thickening and prominent subfoveal fluid , and those in sham-treated patients were poor BCVA , mild foveal thickening , and statin usage . | 179,578 | 2 |
179,579 | Month 24 BCVA 20/100 was predicted by poor baseline BCVA in ranibizumab-treated patients , and by poor baseline BCVA , large intraretinal cystoid spaces , renal disease , and absence of hypercholesterolemia in sham-treated patients . | 179,579 | 2 |
179,580 | Loss of BCVA 15 letters was predicted in sham-treated patients by submacular fluid , intraretinal cystoid spaces , and renal disease . | 179,580 | 2 |
179,581 | Patients with DME and submacular fluid , intraretinal cysts , severe thickening , or renal disease respond poorly when untreated and respond well to ranibizumab treatment . | 179,581 | 3 |
179,582 | Elimination of submacular fluid , intraretinal cysts , and severe thickening are important goals of DME treatment , and in patients with renal disease , treatment should be very aggressive , with a goal of eliminating all macular fluid . | 179,582 | 3 |
179,583 | This study included 54-month-old children with a history of institutional care . | 179,583 | 0 |
179,584 | Our goal was to : ( 1 ) examine differences in indiscriminate social behaviors in children with a history of institutional care compared with home-reared children ; ( 2 ) test whether foster care reduces indiscriminate social behaviors in a randomized controlled trial ; and ( 3 ) examine early predictors of indiscriminate behaviors . | 179,584 | 0 |
179,585 | Participants were 58 children with a history of institutional care and 31 never-institutionalized control ( NIG ) subjects enrolled in a randomized controlled trial of foster care for institutional care , assessed from toddlerhood to 54 months . | 179,585 | 1 |
179,586 | Indiscriminate social behaviors were measured naturalistically by using the Stranger at the Door procedure . | 179,586 | 1 |
179,587 | In the Stranger at the Door procedure , children with a history of institutional care left with a stranger at higher rates than NIG subjects ( 33 % vs. 3.5 % ; P < .001 ) . | 179,587 | 2 |
179,588 | Children in the care as usual group left more than NIG subjects ( 41.9 % vs. 3.6 % ; P .001 ) . | 179,588 | 2 |
179,589 | The differences between the foster care group ( 24.1 % ) and the care as usual group and between foster care group and NIG were not significant . | 179,589 | 2 |
179,590 | In a logistic regression , early disorganized attachment behaviors , baseline developmental quotient , and caregiving quality after randomization contributed to variance at 54 months . | 179,590 | 2 |
179,591 | In the same analysis using only children with a history of institutional care , only disorganized attachment contributed significantly to 54-month indiscriminate social behaviors ( Exp [ B ] = 1.6 [ 95 % confidence interval : 1.1-2 .5 ] ) . | 179,591 | 2 |
179,592 | Observed socially indiscriminate behaviors at 54 months were associated with prolonged exposure to institutional care . | 179,592 | 3 |
179,593 | Young children raised in conditions of deprivation who fail to develop organized attachments as toddlers are at increased risk for subsequent indiscriminate behaviors . | 179,593 | 3 |
179,594 | One goal of guideline-based asthma therapy is minimal use of short-acting agonist ( SABA ) medications . | 179,594 | 4 |
179,595 | Inner-city children with asthma are known to have high SABA use . | 179,595 | 4 |
179,596 | To examine factors associated with high SABA use in inner-city children with asthma . | 179,596 | 0 |
179,597 | One hundred inner-city children with persistent asthma were enrolled into a randomized controlled trial of an emergency department ( ED ) and home intervention . | 179,597 | 1 |
179,598 | All children underwent serologic allergen specific IgE and salivary cotinine testing at the ED enrollment visit . | 179,598 | 1 |
179,599 | Pharmacy records for the past 12 months were obtained . | 179,599 | 1 |
Subsets and Splits