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-"Authors","Author full names","Author(s) ID","Title","Year","Source title","Volume","Issue","Art. No.","Page start","Page end","Page count","Cited by","DOI","Link","Abstract","Author Keywords","Index Keywords","Document Type","Publication Stage","Open Access","Source","EID"
-"Corell M.; Friberg P.; Petzold M.; Löfstedt P.","Corell, Maria (57190133841); Friberg, Peter (58885076400); Petzold, Max (7003628893); Löfstedt, Petra (11141399900)","57190133841; 58885076400; 7003628893; 11141399900","Socioeconomic inequalities in adolescent mental health in the Nordic countries in the 2000s - A study using cross-sectional data from the Health Behaviour in School-aged Children study","2024","Archives of Public Health","82","1","20","","","","","10.1186/s13690-024-01240-5","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184888895&doi=10.1186%2fs13690-024-01240-5&partnerID=40&md5=5a0f7573ad24425dec9e789981c18de7","Background: Adolescents in Sweden experience more mental health problems and lower mental well-being than adolescents in other Nordic countries. According to the literature, one possible explanation may be differences in income inequality. The at-risk-of-poverty rate varies significantly across the Nordic countries, and the highest rate is found in Sweden. The aims of the study were to examine socioeconomic inequalities in subjective health complaints and life satisfaction among adolescents in the Nordic countries during 2002 − 2018 and to explore whether subjective health complaints and life satisfaction were related to income inequality in terms of the at-risk-of-poverty rate at the country level. Methods: Data regarding 15-year-olds from the Health Behaviour in School-aged Children study from five survey rounds (2002 − 2018) were used (n = 41,148). The HBSC Symptoms Checklist and Cantril’s ladder were used as measures of subjective health complaints and life satisfaction, respectively. The Family Affluence Scale, the Perceived Family Wealth item and the at-risk-of-poverty rate in each country were used as measures of individual-level socioeconomic conditions and country-level income inequality. Statistical methods involved ANOVA, multiple linear regressions and multilevel regression analyses. Results: Absolute and relative socioeconomic inequalities in both subjective health complaints and life satisfaction were found in all countries. Sweden showed average socioeconomic inequalities, Iceland the largest and Denmark the smallest. Country-level income inequality in terms of the at-risk-of-poverty rate was associated with a higher prevalence of subjective health complaints and lower levels of life satisfaction in all countries. Conclusion: Socioeconomic inequalities in adolescent mental health and well-being persisted in Nordic countries in the 2000s. Increasing income inequality may have contributed to higher levels of SHC and lower LS in Sweden compared to the other Nordic countries. Policies improving families’ socioeconomic conditions and reducing income inequality at the country level are needed to improve and reduce inequalities in mental health and well-being among adolescents. © The Author(s) 2024.","Adolescent health; At-risk-of-poverty rate; Income inequality; Life satisfaction; Mental health; Nordic countries; Social gradient; Socioeconomic inequalities; Subjective health complaints","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184888895"
-"Pfeiffer E.; Garbade M.; Sachser C.","Pfeiffer, Elisa (57193725666); Garbade, Maike (58264377400); Sachser, Cedric (57164807300)","57193725666; 58264377400; 57164807300","Traumatic events and posttraumatic stress symptoms in a treatment-seeking sample of Ukrainian children during the war","2024","Child and Adolescent Psychiatry and Mental Health","18","1","25","","","","","10.1186/s13034-024-00715-1","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184859010&doi=10.1186%2fs13034-024-00715-1&partnerID=40&md5=c207de6e7b838f2a70445851785fb084","Background: The Russian invasion of Ukraine resulted in a dramatic increase of children and adolescents being confronted with war and other traumatic experiences, which could result in an increase of trauma-related mental health disorders such as posttraumatic stress disorder (PTSD) in an entire generation. This study aims at reporting the prevalence of traumatic events, PTSD, and Complex PTSD (CPTSD) in children and adolescents seeking for mental health treatment since the Russian invasion. Additionally, the consistency of child and caregiver reported trauma, PTSD and CPTSD will be examined. Methods: This study is part of the “TF-CBT Ukraine” project in which Ukrainian therapists were trained in assessing their patients via the “Child and Adolescent Trauma Screen” (CATS-2) before initiating trauma-focused treatment, if indicated. Altogether N = 200 Ukrainian children and adolescents (Mage = 12.01, range 4–21; 62.0% female) were included in the study between October 2022 and August 2023. Data were analysed descriptively, via t-tests and bivariate correlations. Results: The children and adolescents reported on average four different traumatic events, most frequently war (n = 123; 68.7%), bullying threats (n = 71; 39.7%) and domestic violence (n = 68; 38.0%). Almost 70% (n = 123) of the participants fulfilled the DSM-5 PTSD criteria, 31% (n = 56) fulfilled the ICD-11 PTSD criteria and 21% (n = 38) the ICD-11 CPTSD criteria. Rates of PTSD were even higher in preschool children (95%). The comparisons of self-and caregiver reports on traumatic events and PTSD/CPTSD severity scores indicated moderate to high correlations between the patients and their caregivers (r = 0.710–0.767). Conclusions: This study shows that Ukrainian children and adolescents starting treatment report a high number of traumatic events and trauma-related symptoms, which could have a long-lasting negative impact on their social-emotional development and quality of life. The implementation of evidence-based trauma-focused interventions for these children is therefore crucial. © The Author(s) 2024.","Children; PTSD; Trauma; Ukraine; War","","Article","Final","All Open Access; Gold Open Access; Green Open Access","Scopus","2-s2.0-85184859010"
-"ALFadhalah T.; Lari M.; Al Salem G.; Ali S.; Al Kharji H.; Elamir H.","ALFadhalah, Talal (57209570664); Lari, Marjan (58879341700); Al Salem, Gheed (57209142768); Ali, Shaimaa (58879500300); Al Kharji, Hamad (57825529600); Elamir, Hossam (57202301195)","57209570664; 58879341700; 57209142768; 58879500300; 57825529600; 57202301195","Prevalence of pressure injury on the medical wards of public general hospitals in Kuwait: a national cross-sectional study","2024","BMC Health Services Research","24","1","173","","","","","10.1186/s12913-024-10615-x","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184734745&doi=10.1186%2fs12913-024-10615-x&partnerID=40&md5=fc04df0a2b5d5381e459a484fec66bed","Background: Pressure injury is a severe problem that can significantly impact a patient’s health, quality of life, and healthcare expenses. The prevalence of pressure injuries is a widely used clinical indicator of patient safety and quality of care. This study aims to address the research gap that exists on this topic in Kuwait by investigating the prevalence of pressure injuries and preventive measures on the medical wards of the country’s public general hospitals. Methods: A cross-sectional research design was adopted to measure the point prevalence of pressure injuries on 54 medical wards in the public general hospitals. Data, including variables pertaining to hospitals, patients, pressure injuries and preventive practices, were collected using an online form. The data were processed and analysed using Microsoft Excel and SPSS 23 (α level = 0.05). Analysis provided an overview of patient, pressure injury characteristics and preventive measures, and the relationships between the patient and pressure injury characteristics and the prevalence of pressure injuries. A model for predicting the determinants of pressure injury prevalence was constructed from a linear regression analysis. Results: The mean national prevalence of pressure injury was 17.6% (95% CI: 11.3–23.8). Purely community-acquired pressure injuries represent the majority of pressure injuries nationally (58.1%). Regarding preventive measures, “pressure injury assessment on admission” has been provided to 65.5% of patients. Correlation analysis revealed that the only statistically significant correlation with the prevalence of hospital-acquired pressure injury was “pressure injury assessment on admission”, which was strongly negative (ρ = −0.857). Therefore, this was the only variable included in the regression analysis as a predictor of pressure injury prevalence (Beta = 0.839). The results showed many statistically significant differences between hospitals with respect to the variables studied. Conclusions: The national pressure injury prevalence is high compared to the global rate. The higher percentage of purely community-acquired pressure injuries requires particular attention. Many risk factors for the development of pressure injuries are public health concerns, and effective mitigating strategies are needed. Further research is required to assess the knowledge, attitude, and behaviour of nurses with respect to pressure injuries, and to evaluate preventive and management practices. © The Author(s) 2024.","Bedsores; Braden scale; Decubitus ulcers; Hospital-acquired complications; Patient safety; Risk assessment","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184734745"
-"Li X.; Li Y.; Qian L.; Han P.; Feng H.; Jiang H.","Li, Xuemei (58560177900); Li, Yongqi (58560178000); Qian, Lin (58881710900); Han, Peng (57425040400); Feng, Haoxue (57990187900); Jiang, Hui (56401321000)","58560177900; 58560178000; 58881710900; 57425040400; 57990187900; 56401321000","Mothers’ experiences of breast milk expression during separation from their hospitalized infants: a systematic review of qualitative evidence","2024","BMC Pregnancy and Childbirth","24","1","124","","","","","10.1186/s12884-024-06323-3","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184785930&doi=10.1186%2fs12884-024-06323-3&partnerID=40&md5=3954f06ad4e89f16747b78d0548d3620","Background: Mother-infant separation, which is occurring with an increasing incidence, is a barrier to direct breastfeeding. Owing to the importance of breast milk to hospitalized infants, mothers are actively encouraged to express milk during their infants’ neonatal intensive care unit (NICU) stay. However, mothers are often faced with a number of challenges in this process. There is a need to understand such mothers’ real-life experiences of breast milk expression to develop supportive strategies to reduce the burden on mothers and increase breastfeeding rates. Methods: A comprehensive search of 12 databases was conducted for relevant studies published from database construction to December 2022. All qualitative and mixed-method studies published in English and Chinese that reported on mothers’ experiences of human milk expression during separation from their hospitalized infants were included. Two reviewers independently conducted screening, data extraction, and quality appraisal, with disagreements resolved by a third reviewer. The process of searching followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. The JBI Qualitative Assessment and Review Instrument was used to assess study quality and the credibility of study findings. Meta-aggregation was performed to integrate the results. Results: This systematic review aggregated mothers’ experiences of milk expression during separation from their hospitalized infants. Database search yielded 600 records, of which 19 full-text documents were screened. Finally, 13 studies of good quality were included with data from 332 mothers across seven countries. A total of 61 primary findings with illustrations were extracted from the 13 eligible studies, the findings were generalized into 16 categories, and further were concluded as four synthesized findings: purpose and motivation, physical and emotional experiences, barrier factors, and coping styles. Conclusion: Mothers were driven by extrinsic motivation in their decision to express breast milk. They experienced physical exhaustion and many negative emotional feelings while expressing. This process was affected by numerous barriers. Social support was essential to the initiation and maintenance of milk expression. Medical staff and families should pay more attention to the mental health of mothers with infants in the NICU. Future research should incorporate strategies to cope with emotional responses and offer practical strategies for managing milk expression. Systematic review registration: [www.crd.york.ac.uk], identifier [PROSPERO 2022 CRD42022383080]. © The Author(s) 2024.","Breast milk expression; Breastfeeding; Experience; Maternal separation; Meta-aggregation; NICU; Qualitative study","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184785930"
-"Zhao Y.; Zhao H.; Yu H.","Zhao, Ying (57855253300); Zhao, Hang (58879215600); Yu, Hongyu (58022046100)","57855253300; 58879215600; 58022046100","The transcultural adaptation and validation of the Chinese version of the Oral Health Literacy Scale for Diabetic Patients","2024","BMC Oral Health","24","1","198","","","","","10.1186/s12903-024-03965-9","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184739359&doi=10.1186%2fs12903-024-03965-9&partnerID=40&md5=d63d13eb4d8038b4a95b4983d833d730","Background: Diabetic patients’ oral health concerns are a reality for every diabetic patient in China. The attitudes of diabetic patients toward early identification of oral literacy influence oral literacy in diabetes patients. Diabetes patients' oral health literacy is critical for providing focused education and therapies. However, no instrument exists to measure oral health literacy in Chinese diabetic patients. In this study, the English version of the oral health literacy among people living with diabetes (OHLD) scale was cross-culturally validated to provide a reliable tool for assessing the oral health literacy of diabetic patients in China. Objective: The oral literacy among people living with diabetes (OHLD) scale was Chineseized and its reliability and validity tested, and the OHLD scale was revised to test the reliability and validity of the Chinese version of the OHLD scale and to provide a tool for assessing the oral health literacy of diabetic patients in China. Methods: A modified version of the Brislin translation model was used, cross-cultural adaptation was performed through expert consultation and pre-survey, and expert opinion was used to assess content validity to form the Chinese version of the Oral Health Literacy Scale for Diabetic Patients, which was administered to 420 diabetic patients in two tertiary hospitals in Liaoning Province from March to August 2023. The reliability of the scale was tested. SPSS 25.0 and AMOS 23.0 were used to analyze the data. Results: The Chinese version of the OHLD scale consisted of three dimensions and 10 entries. Structure of the validity analysis: three factors were extracted from the exploratory factors with a cumulative variance contribution of 79.794%; Content validity results:An item’s content validity index (I-CVI) was 0.857 to 1 at the entry level, and the content validity index of the scale (S-CVI) was 0.928 at the scale level. The results of the reliability analyses were: the Cronbach's alpha coefficient for the total scale was 0.908; the Cronbach's alpha coefficients for the factors and dimensions were 0.853 to 0.922; the split-half reliability was 0.827; and the test–retest reliability was 0.848. The results of the validation factor analysis showed that (χ2/df) was 1.430, the root mean square of the error of approximation (RMSEA) was 0.045, the comparative fit index (CFI) was 0.989, and the Tucker Lewis index (TLI) was 0.985, which showed that the model had an overall good fit. Conclusion: The Chinese version of the OHLD scale has good reliability and validity and can be used as a valid tool for assessing diabetes mellitus patients in China. © The Author(s) 2024.","Cross-cultural adaptation; Factor analysis; Oral health literacy; Psychometric validation; Reliability; Validity","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184739359"
-"Espinoza J.C.; Sehgal S.; Phuong J.; Bahroos N.; Starren J.; Wilcox A.; Meeker D.","Espinoza, Juan C. (56785374400); Sehgal, Shruti (57224930005); Phuong, Jimmy (55257620100); Bahroos, Neil (55496045600); Starren, Justin (6603888860); Wilcox, Adam (57676462300); Meeker, Daniella (36548693700)","56785374400; 57224930005; 55257620100; 55496045600; 6603888860; 57676462300; 36548693700","Development of a social and environmental determinants of health informatics maturity model","2024","Journal of Clinical and Translational Science","7","1","e266","","","","0","10.1017/cts.2023.691","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180989341&doi=10.1017%2fcts.2023.691&partnerID=40&md5=0cd65f30821e4d0ec0bb35cdc69f2559","Introduction: Integrating social and environmental determinants of health (SEDoH) into enterprise-wide clinical workflows and decision-making is one of the most important and challenging aspects of improving health equity. We engaged domain experts to develop a SEDoH informatics maturity model (SIMM) to help guide organizations to address technical, operational, and policy gaps. Methods: We established a core expert group consisting of developers, informaticists, and subject matter experts to identify different SIMM domains and define maturity levels. The candidate model (v0.9) was evaluated by 15 informaticists at a Center for Data to Health community meeting. After incorporating feedback, a second evaluation round for v1.0 collected feedback and self-assessments from 35 respondents from the National COVID Cohort Collaborative, the Center for Leading Innovation and Collaboration's Informatics Enterprise Committee, and a publicly available online self-assessment tool. Results: We developed a SIMM comprising seven maturity levels across five domains: data collection policies, data collection methods and technologies, technology platforms for analysis and visualization, analytics capacity, and operational and strategic impact. The evaluation demonstrated relatively high maturity in analytics and technological capacity, but more moderate maturity in operational and strategic impact among academic medical centers. Changes made to the tool in between rounds improved its ability to discriminate between intermediate maturity levels. Conclusion: The SIMM can help organizations identify current gaps and next steps in improving SEDoH informatics. Improving the collection and use of SEDoH data is one important component of addressing health inequities.  © The Author(s), 2023. Published by Cambridge University Press on behalf of The Association for Clinical and Translational Science.","clinical and translational research; health equity; informatics; maturity models; Social determinants of health","Article; clinical article; clinical decision making; decision making; health care cost; health disparity; health equity; human; implementation science; information processing; information science; learning health system; maturity; medical informatics; self evaluation; social determinants of health; translational research; translational science; university hospital; workflow","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85180989341"
-"Zhang Y.; Romieu-Hernandez A.; Boehmer T.K.; Azziz-Baumgartner E.; Carton T.W.; Gundlapalli A.V.; Fearrington J.; Nagavedu K.; Dea K.; Moyneur E.; Cowell L.G.; Kaushal R.; Mayer K.H.; Puro J.; Rasmussen S.A.; Thacker D.; Weiner M.G.; Saydah S.; Block J.P.","Zhang, Yongkang (56941929100); Romieu-Hernandez, Alfonso (58067945600); Boehmer, Tegan K. (8350115700); Azziz-Baumgartner, Eduardo (10045986800); Carton, Thomas W. (35602711900); Gundlapalli, Adi V. (6506223668); Fearrington, Julia (57221511981); Nagavedu, Kshema (57193520931); Dea, Katherine (37661247200); Moyneur, Erick (10043775200); Cowell, Lindsay G. (7004190232); Kaushal, Rainu (7005295324); Mayer, Kenneth H. (56760924000); Puro, Jon (37078008000); Rasmussen, Sonja A. (7201675083); Thacker, Deepika (16178670000); Weiner, Mark G. (58881657100); Saydah, Sharon (6602482419); Block, Jason P. (55551008400)","56941929100; 58067945600; 8350115700; 10045986800; 35602711900; 6506223668; 57221511981; 57193520931; 37661247200; 10043775200; 7004190232; 7005295324; 56760924000; 37078008000; 7201675083; 16178670000; 58881657100; 6602482419; 55551008400","Association between SARS-CoV-2 infection and select symptoms and conditions 31 to 150 days after testing among children and adults","2024","BMC Infectious Diseases","24","1","181","","","","","10.1186/s12879-024-09076-8","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184786548&doi=10.1186%2fs12879-024-09076-8&partnerID=40&md5=01455b4e50074356743e3807a753d866","Background: An increasing number of studies have described new and persistent symptoms and conditions as potential post-acute sequelae of SARS-CoV-2 infection (PASC). However, it remains unclear whether certain symptoms or conditions occur more frequently among persons with SARS-CoV-2 infection compared with those never infected with SARS-CoV-2. We compared the occurrence of specific COVID-associated symptoms and conditions as potential PASC 31- to 150-day following a SARS-CoV-2 test among adults and children with positive and negative test results. Methods: We conducted a retrospective cohort study using electronic health record (EHR) data from 43 PCORnet sites participating in a national COVID-19 surveillance program. This study included 3,091,580 adults (316,249 SARS-CoV-2 positive; 2,775,331 negative) and 675,643 children (62,131 positive; 613,512 negative) who had a SARS-CoV-2 laboratory test during March 1, 2020–May 31, 2021 documented in their EHR. We used logistic regression to calculate the odds of having a symptom and Cox models to calculate the risk of having a newly diagnosed condition associated with a SARS-CoV-2 positive test. Results: After adjustment for baseline covariates, hospitalized adults and children with a positive test had increased odds of being diagnosed with ≥ 1 symptom (adults: adjusted odds ratio[aOR], 1.17[95% CI, 1.11–1.23]; children: aOR, 1.18[95% CI, 1.08–1.28]) or shortness of breath (adults: aOR, 1.50[95% CI, 1.38–1.63]; children: aOR, 1.40[95% CI, 1.15–1.70]) 31–150 days following a SARS-CoV-2 test compared with hospitalized individuals with a negative test. Hospitalized adults with a positive test also had increased odds of being diagnosed with ≥ 3 symptoms or fatigue compared with those testing negative. The risks of being newly diagnosed with type 1 or type 2 diabetes (adjusted hazard ratio[aHR], 1.25[95% CI, 1.17–1.33]), hematologic disorders (aHR, 1.19[95% CI, 1.11–1.28]), or respiratory disease (aHR, 1.44[95% CI, 1.30–1.60]) were higher among hospitalized adults with a positive test compared with those with a negative test. Non-hospitalized adults with a positive test also had higher odds or increased risk of being diagnosed with certain symptoms or conditions. Conclusions: Patients with SARS-CoV-2 infection, especially those who were hospitalized, were at higher risk of being diagnosed with certain symptoms and conditions after acute infection. © The Author(s) 2024.","COVID-19 pandemic; Electronic health record; Long-COVID; SARS-CoV-2","","Article","Final","All Open Access; Gold Open Access; Green Open Access","Scopus","2-s2.0-85184786548"
-"Barcellona C.; Mariñas Y.B.; Tan S.Y.; Lee G.; Ko K.C.; Chham S.; Chhorvann C.; Leerapan B.; Tien N.P.; Lim J.","Barcellona, Capucine (57867424700); Mariñas, Yzabel Bryanna (58884878100); Tan, Si Ying (55955148900); Lee, Gabriel (58739460000); Ko, Khin Chaw (58739460100); Chham, Savina (57219399292); Chhorvann, Chhea (35309581000); Leerapan, Borwornsom (55627557800); Tien, Nam Pham (58885520300); Lim, Jeremy (24073381300)","57867424700; 58884878100; 55955148900; 58739460000; 58739460100; 57219399292; 35309581000; 55627557800; 58885520300; 24073381300","Correction to: Measuring health equity in the ASEAN region: conceptual framework and assessment of data availability (International Journal for Equity in Health, (2023), 22, 1, (251), 10.1186/s12939-023-02059-2)","2024","International Journal for Equity in Health","23","1","24","","","","","10.1186/s12939-023-02085-0","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184890419&doi=10.1186%2fs12939-023-02085-0&partnerID=40&md5=b503b2353d6c69873b1d8332ef362884","After publication of this article [1], the authors reported that in this article the author name Yzabel Bryanna Mariñas, was incorrectly written as Bryanna Yzabel Mariñas. The original article [1] has been corrected. © The Author(s) 2023.","","","Erratum","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184890419"
-"Lo R.F.; Schumacher A.; LaForge-Mackenzie K.; Cost K.T.; Crosbie J.; Charach A.; Anagnostou E.; Birken C.S.; Monga S.; Korczak D.J.","Lo, Ronda F (58884843800); Schumacher, Anett (58822478700); LaForge-Mackenzie, Kaitlyn (56125350100); Cost, Katherine Tombeau (55634108900); Crosbie, Jennifer (7005471624); Charach, Alice (7801313238); Anagnostou, Evdokia (8708847900); Birken, Catherine S. (6506310618); Monga, Suneeta (58863980700); Korczak, Daphne J. (10439676300)","58884843800; 58822478700; 56125350100; 55634108900; 7005471624; 7801313238; 8708847900; 6506310618; 58863980700; 10439676300","Evaluation of an automated matching system of children and families to virtual mental health resources during COVID-19","2024","Child and Adolescent Psychiatry and Mental Health","18","1","24","","","","","10.1186/s13034-024-00716-0","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184914709&doi=10.1186%2fs13034-024-00716-0&partnerID=40&md5=1c5141c1f9ab1f796037b7428a64d406","Background: Children and their families often face obstacles in accessing mental health (MH) services. The purpose of this study was to develop and pilot test an electronic matching process to match children with virtual MH resources and increase access to treatment for children and their families during COVID-19. Methods: Within a large observational child cohort, a random sample of 292 families with children ages 6–12 years were invited to participate. Latent profile analysis indicated five MH profiles using parent-reported symptom scores from validated depression, anxiety, hyperactivity, and inattention measures: (1) Average Symptoms, (2) Low Symptoms, (3) High Symptoms, (4) Internalizing, and (5) Externalizing. Children were matched with virtual MH resources according to their profile; parents received surveys at Time 1 (matching process explanation), Time 2 (match delivery) and Time 3 (resource uptake). Data on demographics, parent MH history, and process interest were collected. Results: 128/292 families (44%) completed surveys at Time 1, 80/128 families (63%) at Time 2, and a final 67/80 families (84%) at Time 3, yielding an overall uptake of 67/292 (23%). Families of European-descent and those with children assigned to the Low Symptoms profile were most likely to express interest in the process. No other factors were associated with continued interest or uptake of the electronic matching process. Most participating parents were satisfied with the process. Conclusions: The electronic matching process delivered virtual MH resources to families in a time-efficient manner. Further research examining the effectiveness of electronically matched resources in improving children’s MH symptoms is needed. © The Author(s) 2024.","Adolescent; Child; Mental health profiles; Resource matching","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184914709"
-"Kanani F.; Shahid S.; Sameer D.; Maqsood S.","Kanani, Fatima (36465258100); Shahid, Saba (53871926900); Sameer, Dua (58768215900); Maqsood, Sidra (57215928287)","36465258100; 53871926900; 58768215900; 57215928287","Selective screening for inherited metabolic disorders in a tertiary care hospital of Karachi – A retrospective chart review","2024","Pakistan Journal of Medical Sciences","40","2","","80","84","4","0","10.12669/pjms.40.2(ICON).8985","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179984595&doi=10.12669%2fpjms.40.2%28ICON%29.8985&partnerID=40&md5=0637ce2ede82049327637a5769559415","Background & Objective: Selective high-risk screening of children suspected of having inherited metabolic disorders was conducted jointly by Chemical Pathology section and the Pediatric Department of Indus Hospital and Health Network-(IHHN) from October 2020-March 2022. Tandem mass spectrometry (MS) for newborn screening was recently introduced in a local laboratory. We did a selective high screening of children for metabolic disorders by using MS for neonates and other relevant tests for older children in our hospital. The present study was undertaken to get an estimate of the number of metabolic cases screened and identified after inclusion of an extended workup. Methods: This is a retrospective chart review of children who were selectively screened for IMDs. Patients’ records with ages ranging from birth to fourteen years of age were retrieved from the electronic records department of IHHN from October 2020 to March 2022. Records were searched for demographic data, history, signs, symptoms, and lab investigations. All relevant information was recorded on a pre-designed questionnaire. Results: A total of 178 children were screened for inherited metabolic disorders. Majority of the children screened were less than one month of age 96 (54%). Consanguinity was noted in 74 (41.5%) children. Most common symptoms observed were failure to thrive in 77 children (43%), hypoglycemia in 45 children (25%), and feeding difficulty in 36 children (20%). Inherited metabolic disorders were confirmed in 12 children out of which five had congenital adrenal hyperplasia, four had cystic fibrosis and three children had congenital hypothyroidism. Conclusion: In the present study, we were able to screen several children after inclusion of an extended metabolic workup. However, confirmation of many disorders like fatty acid oxidation defects, disorders of carbohydrate metabolism, and sphingolipidosis could not be done due to lack of confirmatory tests. We recommend that confirmatory tests of these disorders be included in local labs. © 2024, Professional Medical Publications. All rights reserved.","Children; Inherited Metabolic Disorder; Selective Screening; Tandem Mass Spectrometry","adolescent; age distribution; Article; child; clinical feature; congenital adrenal hyperplasia; congenital hypothyroidism; consanguinity; cystic fibrosis; demography; electronic medical record; failure to thrive; feeding disorder; female; genetic disorder; high performance liquid chromatography; human; hypoglycemia; infant; major clinical study; male; medical history; metabolic disorder; newborn screening; Pakistan; retrospective study; sex difference; symptomatology; tandem mass spectrometry; tertiary care center","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85179984595"
-"Shiroiwa T.; Murata T.; Morii Y.; Hoshino E.; Fukuda T.","Shiroiwa, Takeru (23006884300); Murata, Tatsunori (56967537600); Morii, Yasuhiro (58480701500); Hoshino, Eri (58480701600); Fukuda, Takashi (55728873100)","23006884300; 56967537600; 58480701500; 58480701600; 55728873100","Comparison of four value sets derived using different TTO and DCE approaches: application to the new region-specific PBM, AP-7D","2024","Health and Quality of Life Outcomes","22","1","16","","","","","10.1186/s12955-024-02233-2","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184794330&doi=10.1186%2fs12955-024-02233-2&partnerID=40&md5=0057b2f56b35282d93ab98b838de9be8","Background: AP-7D is a newly developed preference-based measure (PBM) in East and Southeast Asia. However, no value set has been established yet. Comparison of the characteristics of value sets obtained by different methods is necessary to consider the most appropriate methodology for valuation survey of AP-7D. Method: We surveyed the general population’s preference of AP-7D health states by four valuation methods (a) composite time trade-off (cTTO); (b) simple discrete choice experiment (DCE); (c) DCE with duration; and (d) ternary DCE. In Japan, we collected approximately 1,000 samples for cTTO tasks through a face-to-face survey and 2,500 samples for each of the three DCE tasks. Respondents were selected through quota sampling based on the sex and age. The cTTO data were analyzed using a linear mixed and tobit model; the DCE data were analyzed using a simple and panel conditional logit model. Where the results of the analysis showed inconsistencies, a constrained model was used. Results: Since all the unconstrained models, except simple DCE, showed one or more inconsistencies, the constrained model was used for the analyses. The minimum values for the models were as follows: TTO model, -0.101; simple DCE model, -0.106; DCE with duration model, -0.706; ternary DCE model, -0.306. The score for the DCE with the duration model was much lower than that for the other models. Although the value sets for AP-7D differed among the four valuation methods, the ternary DCE model showed intermediate characteristics between those of the cTTO and DCE with duration models. As compared with to EQ-5D-5L, the distributions of all the scores on the Japanese AP-7D moved to the left. Although “Energy” was one of the domains with the least influence on the AP-7D score in all four models, “Burden to others” had the largest impact on the preferences. Conclusion: We constructed four value sets using different TTO and DCE methods. Our findings are expected not only to contribute to the development of AP-7D, but also other preference-based measures. © The Author(s) 2024.","AP-7D; DCE; Preference-based measure; QALY; TTO","","Article","Final","All Open Access; Gold Open Access; Green Open Access","Scopus","2-s2.0-85184794330"
-"Zahid Q.-U.-A.; Khursheed N.; Adnan F.; Zafar A.","Zahid, Qurat-Ul-Ain (57967451500); Khursheed, Nazia (16067019200); Adnan, Fareeha (57405064300); Zafar, Adeel (57548505300)","57967451500; 16067019200; 57405064300; 57548505300","Concordance and discordance of GeneXpert MTB/RIF and conventional culture method for diagnosis of Extra-Pulmonary Tuberculosis at a tertiary care hospital in Pakistan","2024","Pakistan Journal of Medical Sciences","40","2","","S64","S69","5","0","10.12669/pjms.40.2(ICON).8967","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179667760&doi=10.12669%2fpjms.40.2%28ICON%29.8967&partnerID=40&md5=69e51f999b63b2cc2d6030e2e2a4de3a","Objective: To identify concordance and discordance between GeneXpert MTB/RIF assay and gold standard bacteriologic culture for the diagnosis of Mycobacterium tuberculosis (MTB) in Extra-Pulmonary tuberculosis (EPTB) specimens in our region. Methods: This is a retrospective cross-sectional study conducted at the Indus Hospital and Health Network. Data from 1st January, 2020 to 31st December, 2021 was analyzed. A total of 1499 EPTB specimens were included for which GeneXpert was requested along with acid-fast bacteria (AFB) culture from the same specimen. Specimens were processed according to specimen type following standard operating procedures of the laboratory. Fluorescent staining was performed on all specimens along with bacteriologic culture. The GeneXpert MTB/RIF assay was carried out in exact accordance with the manufacturer’s instructions. Results: Out of 1499 EPTB specimens, 1370 (91.39%) specimens exhibited concordance between GeneXpert and conventional culture method, while 129 (8.60%) specimens showed discordance. GeneXpert exhibited sensitivity and specificity of 69.4% and 94.3% respectively in comparison to culture. Conclusion: GeneXpert sensitivity for the diagnosis of EPTB varied with the site involved. Lower sensitivity was observed in ascitic and pleural fluids as compared to higher sensitivity observed among urine samples and pus aspirates. However, given the quick turnaround time and ease of use, it is a helpful tool in the diagnosis of EPTB when utilized in the appropriate clinical context. Caution is advised while interpreting negative GeneXpert results in endemic settings and should be interpreted along with other supporting clinical and diagnostic features. © 2024, Professional Medical Publications. All rights reserved.","Conventional culture; Extrapulmonary tuberculosis; GeneXpert MTB/RIF; Mycobacterium tuberculosis; Pakistan","fluorescent dye; abscess; acid fast bacterium; adult; aged; Article; ascites fluid; bacterium culture; bone marrow; cerebrospinal fluid; cold abscess; controlled study; cross-sectional study; data analysis; demographics; diagnostic accuracy; diagnostic test accuracy study; extrapulmonary tuberculosis; female; gastric suction; gold standard; granulation tissue; human; intermethod comparison; interrater reliability; major clinical study; male; Mycobacterium tuberculosis; nonhuman; Pakistan; pericardial effusion; peritoneal fluid; pleura fluid; predictive value; pus; pus aspirate; retrospective study; sensitivity and specificity; synovial fluid; tertiary care center; urine; very elderly","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85179667760"
-"Wali A.S.; Ali M.M.; Bibi R.; Rahim A.","Wali, Aisha Syed (7003968193); Ali, Maria Mushtaq (57405722500); Bibi, Rabia (58767625900); Rahim, Anum (57222058913)","7003968193; 57405722500; 58767625900; 57222058913","The clinical manifestations and pregnancy outcomes of COVID-19 infection at a tertiary care hospital","2024","Pakistan Journal of Medical Sciences","40","2","","S15","S20","5","1","10.12669/pjms.40.2(ICON).8949","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178948811&doi=10.12669%2fpjms.40.2%28ICON%29.8949&partnerID=40&md5=27ce5df1b4483d585ec821d9a6b994a5","Objective: To evaluate clinical presentation and pregnancy outcomes in pregnant women with Covid-19 infection in our local tertiary care from lower middle-income country. Methods: A retrospective study was conducted at Obstetrics & Gynecology department, Sheikh Saeed Memorial Hospital (SSMH) of The Indus Hospital and Health Network (IHHN) from March 2020 to August 2021. Data of 422 admitted pregnant women with COVID-19 infection was retrieved for demographic and clinical information, laboratory tests, pregnancy outcome, and neonatal outcomes on RED-Cap and analyzed on SPSS 26. Univariate and multivariable logistic regression analyses were performed to estimate odds ratios (OR) for symptomology with categorical variables and feto-maternal outcome. Results: Of the total 422 pregnant women, 24.4% were symptomatic, 74.7% exhibiting mild symptoms. Largely reported symptoms were fever (71.8%), cough (36.9%) and body ache (35.0%); while odds of symptomatic COVID-19 infection was less in educated pregnant women (OR 0.3; 95% CI 0.1-0.9) compared to uneducated. Amongst maternal comorbidities, odds of having symptomatic COVID-19 infection were 3.8 times (95% CI 1.1-13.0) in women with chronic hypertension and 5.5 times (95% CI 2.9-10.4) in women with diabetes. Symptomatic women had significantly greater incidence of miscarriages (p= 0.009), PPROM (p= 0.001), preterm birth (p= 0.000), preeclampsia (p= 0.000), placental abruption (p= 0.006) and maternal ICU admission (p= 0.000) than asymptomatic patients. Still birth was higher (6.4% vs 1.3%, p-value= 0.013) in symptomatic group. The odds of having severe maternal outcome were higher (OR=3.5; 95% CI 1.9-6.0) in symptomatic pregnant women. Conclusion: Majority of pregnant women were asymptomatic. Symptomatic women with COVID-19 infection had an increased risk of adverse feto-maternal outcome. © 2024, Professional Medical Publications. All rights reserved.","Clinical manifestations; COVID-19 infection; Pregnancy; Pregnancy Outcome","adult; Article; asymptomatic disease; chronic disease; clinical feature; comorbidity; coronavirus disease 2019; coughing; diabetes mellitus; disease severity; female; fetus outcome; fever; hospital admission; human; hypertension; incidence; intensive care unit; low income country; major clinical study; middle income country; pain; preeclampsia; pregnancy outcome; pregnant woman; prematurity; preterm rupture of membranes; risk factor; solutio placentae; spontaneous abortion; stillbirth; tertiary care center; young adult","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85178948811"
-"Çağlar S.; Okuyan C.B.","Çağlar, Songül (57223849314); Okuyan, Canan Birimoğlu (57222639051)","57223849314; 57222639051","The impact of distance learning on the attitudes of nursing students: An online survey study","2024","Acta Scientiarum - Health Sciences","46","1","e63213","","","","0","10.4025/actascihealthsci.v46i1.63213","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179705438&doi=10.4025%2factascihealthsci.v46i1.63213&partnerID=40&md5=435e246666d206ab6b7d7a29e16f7271","The COVID-19 pandemic has led to the transition to distance education in nursing education. However, Nursing students are not accustomed to learning through distance learning.This research aimed to determine the effect of distance education method on the attitudes of nursing students towards the profession during the COVID-19 pandemic. This research was cross-sectional in design. Data were collected with an online survey about distance education and the nursing profession through Google Forms in November 2020 and June 2021 at the nursing department. The students' views on distance education were moderate (46.66±8.81), and their attitudes towards the nursing profession were good (86±13.86). There was no statistically significant relationship between scale scores. There was no statistically significant difference in terms of students' grade levels, graduating from a distance education institution before, taking courses through distance education before the COVID-19 pandemic and clinical practice before the pandemic, and their attitudes towards both distance education and the nursing profession. Our study shows that the distance learning method does not affect students' attitudes toward the nursing profession. © 2024, Eduem - Editora da Universidade Estadual de Maringa. All rights reserved.","COVID-19; distance education; nursing education; nursing student; online learning","adult; age distribution; Article; clinical practice; controlled study; coronavirus disease 2019; cross-sectional study; demographics; distance learning; e-learning; educational status; female; gender; health survey; human; male; marriage; nursing student; online system; pandemic; population structure; sample size; social participation; sociodemographics; student attitude; young adult","Article","Final","","Scopus","2-s2.0-85179705438"
-"Keshmiri F.","Keshmiri, Fatemeh (57191480994)","57191480994","Exploring workplace mental health: educator perspectives and factors in the medical education system – a mixed method study","2024","BMC Medical Education","24","1","127","","","","","10.1186/s12909-024-05095-w","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184790288&doi=10.1186%2fs12909-024-05095-w&partnerID=40&md5=f4bb89080eebbe2ab1d7f3ec8e65d60d","Introduction: The present study aimed to assess the status of workplace mental health from the viewpoints of educators, and explore their experiences concerning influential factors on occupational mental health at Shahid Sadoughi University of Medical Sciences. Methods: The study was a sequential mixed-method study that was conducted in quantitative and qualitative phases. In the quantitative phase, the perception of educators (n = 205) was assessed by a Workplace Mental Health Questionnaire, including 37 items in 9 categories (including an opportunity to control, an opportunity to use skills, external goals created, environmental diversity, environmental clarity, access to money, physical security, opportunity to contact others, and valuable social status and position). In the qualitative phase, data were collected using semi-structured interviews (n = 21) and were analyzed based on the conventional content analysis approach. Results: The results showed that the status of workplace mental health of educators was at a moderate level (mean (± SD) = 115.87 (±3.21). The highest and lowest scores of the median were reported in the domains of “opportunity for control” (median = 4) and “opportunity to contact others” (median = 2.75), respectively. The theme of “contrast between preferences and disappointments in the development path” with two categories including “induced demotivation of system elements” and “tendencies of promotion” was explored from the educators’ perspective. Conclusion: The results indicated the moderate level of mental health of educators was influenced by the contrast between preferences and disappointments in the development path. The tendency of educators for promotion was explored as a positive factor in the mental health of educators in the academic environment. A growing desire for creative advancement among educators as a personal factor and a demand to stay updated with all developments as a system factor explained the positive experiences of educators in the university. The results showed the gap between the current situation and the desired state of occupational mental health may result from cultural challenges, lack of adherence to professionalism at the personal level (non-compliance with the principles of well-being and excellence), and interpersonal level (non-compliance with respect, justice, etc.). Moreover, factors disrupting occupational mental health at the system level explored in job stress, a resilient culture, lack of managerial support, ingratitude, lack of reward-effort matching mechanism, and lack of resources. © The Author(s) 2024.","Educator; Faculty member; Mixed-method study; Occupational health; Psychological health; Teacher; Well-being; Workplace mental health","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184790288"
-"Meng Q.; Zhang Y.; He D.; Xia Y.; Fu J.; Dang C.","Meng, Qiyue (58529314000); Zhang, Yibo (57209078045); He, Da (58861478300); Xia, Yu (57040244000); Fu, Jie (58861228500); Dang, Chenyuan (56954401700)","58529314000; 57209078045; 58861478300; 57040244000; 58861228500; 56954401700","Metagenomic perspectives on antibiotic resistance genes in tap water: The environmental characteristic, potential mobility and health threat","2025","Journal of Environmental Sciences (China)","147","","","582","596","14","0","10.1016/j.jes.2023.12.023","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183944237&doi=10.1016%2fj.jes.2023.12.023&partnerID=40&md5=14d72c7bf1feb0b671beac5693373280","As an emerging environmental contaminant, antibiotic resistance genes (ARGs) in tap water have attracted great attention. Although studies have provided ARG profiles in tap water, research on their abundance levels, composition characteristics, and potential threat is still insufficient. Here, 9 household tap water samples were collected from the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) in China. Additionally, 75 sets of environmental sample data (9 types) were downloaded from the public database. Metagenomics was then performed to explore the differences in the abundance and composition of ARGs. 221 ARG subtypes consisting of 17 types were detected in tap water. Although the ARG abundance in tap water was not significantly different from that found in drinking water plants and reservoirs, their composition varied. In tap water samples, the three most abundant classes of resistance genes were multidrug, fosfomycin and MLS (macrolide-lincosamide-streptogramin) ARGs, and their corresponding subtypes ompR, fosX and macB were also the most abundant ARG subtypes. Regarding the potential mobility, vanS had the highest abundance on plasmids and viruses, but the absence of key genes rendered resistance to vancomycin ineffective. Generally, the majority of ARGs present in tap water were those that have not been assessed and are currently not listed as high-threat level ARG families based on the World Health Organization Guideline. Although the current potential threat to human health posed by ARGs in tap water is limited, with persistent transfer and accumulation, especially in pathogens, the potential danger to human health posed by ARGs should not be ignored. © 2024","Antibiotic resistance genes; Health threat; Plasmids; Tap water; Viruses","China; Guangdong; Hong Kong; Antibiotics; Health risks; Potable water; Reservoirs (water); Viruses; Antibiotic resistance genes; Environmental characteristic; Health threat; Human health; Metagenomics; Plasmid; Potential mobility; Potential threats; Tap water; Tap-water samples; antibiotic resistance; drinking water; gene expression; genomics; mobility; plasmid; water quality; Genes","Article","Final","","Scopus","2-s2.0-85183944237"
-"Humayun M.; Alsirhani A.; Alserhani F.; Shaheen M.; Alwakid G.","Humayun, Mamoona (56580449600); Alsirhani, Amjad (57417155400); Alserhani, Faeiz (35097295500); Shaheen, Momina (57205752463); Alwakid, Ghadah (57199285762)","56580449600; 57417155400; 35097295500; 57205752463; 57199285762","Transformative synergy: SSEHCET—bridging mobile edge computing and AI for enhanced eHealth security and efficiency","2024","Journal of Cloud Computing","13","1","37","","","","","10.1186/s13677-024-00602-2","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184848642&doi=10.1186%2fs13677-024-00602-2&partnerID=40&md5=c515cd33be3cf7970aa542e456a0f47a","Blockchain technologies (BCT) are utilized in healthcare to facilitate a smart and secure transmission of patient data. BCT solutions, however, are unable to store data produced by IoT devices in smart healthcare applications because these applications need a quick consensus process, meticulous key management, and enhanced eprivacy standards. In this work, a smart and secure eHealth framework SSEHCET (Smart and Secure EHealth Framework using Cutting-edge Technologies) is proposed that leverages the potentials of modern cutting-edge technologies (IoT, 5G, mobile edge computing, and BCT), which comprises six layers: 1) The sensing layer-WBAN consists of medical sensors that normally are on or within the bodies of patients and communicate data to smartphones. 2) The edge layer consists of elements that are near IoT devices to collect data. 3) The Communication layer leverages the potential of 5G technology to transmit patients' data between multiple layers efficiently. 4) The storage layer consists of cloud servers or other powerful computers. 5) Security layer, which uses BCT to transmit and store patients' data securely. 6) The healthcare community layer includes healthcare professionals and institutions. For the processing of medical data and to guarantee dependable, safe, and private communication, a Smart Agent (SA) program was duplicated on all layers. The SA leverages the potential of BCT to protect patients' privacy when outsourcing data. The contribution is substantiated through a meticulous evaluation, encompassing security, ease of use, user satisfaction, and SSEHCET structure. Results from an in-depth case study with a prominent healthcare provider underscore SSEHCET's exceptional performance, showcasing its pivotal role in advancing the security, usability, and user satisfaction paradigm in modern eHealth landscapes. © The Author(s) 2024.","AI; Blockchain; eHealth; IoT; Mobile Edge Computing; Smart Agent; WBAN","5G mobile communication systems; Blockchain; Data handling; Hospital data processing; Internet of things; Medical computing; mHealth; Mobile edge computing; Block-chain; Cutting edge technology; E-health securities; Ehealth; IoT; Patient data; Secure transmission; Smart agents; Users' satisfactions; WBAN; Digital storage","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184848642"
-"Isaacs A.N.; Mitchell E.K.L.","Isaacs, Anton N. (23466815400); Mitchell, Eleanor K. L. (7201803866)","23466815400; 7201803866","Mental health integrated care models in primary care and factors that contribute to their effective implementation: a scoping review","2024","International Journal of Mental Health Systems","18","1","5","","","","","10.1186/s13033-024-00625-x","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184879380&doi=10.1186%2fs13033-024-00625-x&partnerID=40&md5=f0d978ba2312226901b4253883ab824f","Background: In the state of Victoria, Australia, the 111-day lockdown due to the COVID-19 pandemic exacerbated the population’s prevailing state of poor mental health. Of the 87% of Australians who visit their GP annually, 71% of health problems they discussed related to psychological issues. This review had two objectives: (1) To describe models of mental health integrated care within primary care settings that demonstrated improved mental health outcomes that were transferable to Australian settings, and (2) To outline the factors that contributed to the effective implementation of these models into routine practice. Methods: A scoping review was undertaken to synthesise the evidence in order to inform practice, policymaking, and research. Data were obtained from PubMed, CINAHL and APA PsycINFO. Results: Key elements of effective mental health integrated care models in primary care are: Co-location of mental health and substance abuse services in the primary care setting, presence of licensed mental health clinicians, a case management approach to patient care, ongoing depression monitoring for up to 24 months and other miscellaneous elements. Key factors that contributed to the effective implementation of mental health integrated care in routine practice are the willingness to accept and promote system change, integrated physical and mental clinical records, the presence of a care manager, adequate staff training, a healthy organisational culture, regular supervision and support, a standardised workflow plan and care pathways that included clear role boundaries and the use of outcome measures. The need to develop sustainable funding mechanisms has also been emphasized. Conclusion: Integrated mental health care models typically have a co-located mental health clinician who works closely with the GP and the rest of the primary care team. Implementing mental health integrated care models in Australia requires a ‘whole of system’ change. Lessons learned from the Mental Health Nurse Incentive Program could form the foundation on which this model is implemented in Australia. © The Author(s) 2024.","Care coordination; Collaborative care; Integrated care; Mental disorders; Mental health services; Models, Organizational; Patient-Centered Care; Primary health care","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184879380"
-"Shen Y.; Li H.; Sun C.; Ji H.; Zhang D.; Hu K.; Tang Y.; Chen Y.; Wei Z.; Lv J.","Shen, Yue (58861727900); Li, Huanyu (57924135200); Sun, Can (58885700400); Ji, Hongtao (58885695600); Zhang, Daojun (58885725400); Hu, Kun (57924294500); Tang, Yiqi (57923979100); Chen, Yu (58885712300); Wei, Zikun (57924452800); Lv, Junwei (58885712400)","58861727900; 57924135200; 58885700400; 58885695600; 58885725400; 57924294500; 57923979100; 58885712300; 57924452800; 58885712400","Optimizing skin disease diagnosis: harnessing online community data with contrastive learning and clustering techniques","2024","npj Digital Medicine","7","1","28","","","","0","10.1038/s41746-024-01014-x","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184952114&doi=10.1038%2fs41746-024-01014-x&partnerID=40&md5=e7f9271c291bf2d04746e6f69a17a0bc","Skin diseases pose significant challenges in China. Internet health forums offer a platform for millions of users to discuss skin diseases and share images for early intervention, leaving large amount of valuable dermatology images. However, data quality and annotation challenges limit the potential of these resources for developing diagnostic models. In this study, we proposed a deep-learning model that utilized unannotated dermatology images from diverse online sources. We adopted a contrastive learning approach to learn general representations from unlabeled images and fine-tuned the model on coarsely annotated images from Internet forums. Our model classified 22 common skin diseases. To improve annotation quality, we used a clustering method with a small set of standardized validation images. We tested the model on images collected by 33 experienced dermatologists from 15 tertiary hospitals and achieved a 45.05% top-1 accuracy, outperforming the published baseline model by 3%. Accuracy increased with additional validation images, reaching 49.64% with 50 images per category. Our model also demonstrated transferability to new tasks, such as detecting monkeypox, with a 61.76% top-1 accuracy using only 50 additional images in the training process. We also tested our model on benchmark datasets to show the generalization ability. Our findings highlight the potential of unannotated images from online forums for future dermatology applications and demonstrate the effectiveness of our model for early diagnosis and potential outbreak mitigation. © The Author(s) 2024.","","Cluster analysis; Deep learning; Diagnosis; E-learning; Image enhancement; Learning systems; Social networking (online); Clustering techniques; Data annotation; Data quality; Diagnostic model; Disease diagnosis; Early intervention; Large amounts; Learning techniques; On-line communities; Skin disease; Dermatology","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184952114"
-"Baptista S.C.P.D.; Juliani C.M.C.M.; Corrente J.E.; Trettene A.S.; Lima S.A.M.; Spiri W.C.","Baptista, Simone Cristina Paixão Dias (57202304787); Juliani, Carmen Maria Casquel Monti (23473240200); Corrente, José Eduardo (36943769300); Trettene, Armando Dos Santos (56037261100); Lima, Silvana Andrea Molina (55026420100); Spiri, Wilza Carla (16643532000)","57202304787; 23473240200; 36943769300; 56037261100; 55026420100; 16643532000","Patient profile and reasons for the absence from scheduled medical appointments","2024","Acta Scientiarum - Health Sciences","46","1","e63374","","","","0","10.4025/actascihealthsci.v46i1.63374","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179678204&doi=10.4025%2factascihealthsci.v46i1.63374&partnerID=40&md5=31bd87c1829bdd1af32a04658bf45b69","Organizing health services is a challenge for managers. Moreover, patients’ absenteeism to appointments is a relevant issue. This study aims to evaluate the profile of absent users, the medical specialty, and reasons for absence from medical consultations in a reference clinic. This is a cross-sectional study conducted at a tertiary hospital in the state of São Paulo. Data was obtained from reports from the Hospital Center for Medical Informatics and electronic patient records (from January 1st to December 31st, 2018). Structured interviews were carried out (from April 2018 to February 2019) by phone with a random sample of 317 patients who were aged 18 years old or above and missed consultations in twelve medical specialties, after approval by the Research Ethics Committee. Analysis were performed using descriptive and analytical statistics, with a significance level set at 5%. In total, 69.09% of patients say they missed consultations. It is noteworthy that 18.06% of patients said they attended consultations, followed by those who claimed to be sick or hospitalized (16.98%, p-value=0.0006). Analyzing the context and reasons for absences generates knowledge for service management. We found inadequacies in scheduling and system records. Patients and health services must be co-responsible for optimizing the use of public health resources. © 2024, Eduem - Editora da Universidade Estadual de Maringa. All rights reserved.","Absenteeism; ambulatory assistance; non-attending patients; nursing administration research","absenteeism; adult; ambulatory care; Article; female; hospital management; hospital patient; human; major clinical study; male; nursing management; nursing research","Article","Final","","Scopus","2-s2.0-85179678204"
-"Zainal Arifen Z.N.; Haron H.; Shahar S.; Harun Z.; Michael V.; You Y.X.; Manaf Z.A.; Majid H.A.; Chia Y.C.; He F.J.; Brown M.K.; MacGregor G.A.","Zainal Arifen, Zainorain Natasha (57997906900); Haron, Hasnah (57218422752); Shahar, Suzana (6603431261); Harun, Zaliha (54943413000); Michael, Viola (57204959928); You, Yee Xing (57205231315); Manaf, Zahara Abdul (57412437700); Majid, Hazreen Abdul (57209075493); Chia, Yook Chin (57204080905); He, Feng J. (34770124500); Brown, Mhairi Karen (57210725219); MacGregor, Graham A. (7102241803)","57997906900; 57218422752; 6603431261; 54943413000; 57204959928; 57205231315; 57412437700; 57209075493; 57204080905; 34770124500; 57210725219; 7102241803","Perceptions, barriers and enablers on salt reduction in the out-of-home sectors in Malaysia (MySaltOH) from the perspective of street food vendors, caterers and consumers","2024","Public Health Nutrition","27","1","2300277","","","","0","10.1017/S136898002300277X","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180070417&doi=10.1017%2fS136898002300277X&partnerID=40&md5=9a221a249ea01d0605994da525b01316","Objective: To explore the perspectives, barriers and enablers on salt reduction in out-of-home sectors in Malaysia among street food vendors, caterers and consumers. Design: A qualitative study involving twenty-two focus group discussions and six in-depth interviews was conducted, recorded and transcribed verbatim. An inductive thematic analysis approach was employed to analyse the data. Setting: Two in-depth interviews and twenty-two focus group discussions were conducted face-to-face. Four in-depth interviews were conducted online. Participants: Focus group discussions were conducted among twenty-three street food vendors, twenty-one caterers and seventy-six consumers of various eateries. In-depth interviews were conducted among two street food vendors and four caterers, individually. Results: Consumers and food operators perceived a high-salt intake within Malaysia’s out-of-home food sectors. Food operators emphasised the necessity for a comprehensive salt reduction policy in the out-of-home sector involving all stakeholders. Consumers faced limited awareness and knowledge, counterproductive practices among food operators and challenges in accessing affordable low-Na food products, whereas food operators faced the lack of standardised guidelines and effective enforcement mechanisms and uncooperative consumer practices. Both groups expressed that food quality and price of salt were also the barriers, and they advocated for awareness promotion, enhanced regulation of manufactured food products and stricter enforcement targeting vendors. Consumers also suggested promoting and recognising health-conscious food premises, whereas food operators suggested on knowledge enhancement tailored to them, strategies for gaining consumers acceptance and maintaining food quality. Conclusions: These findings provide valuable insights that serve as foundational evidence for developing and implementing salt reduction policies within Malaysia’s out-of-home sectors. © The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society.","Barriers; Caterers; Consumers; Enablers; Food vendors; Out-of-home sectors; Perceptions; Salt reduction","Food; Food Services; Humans; Malaysia; Qualitative Research; Sodium Chloride, Dietary; catering service; food; human; Malaysia; qualitative research; salt intake","Article","Final","","Scopus","2-s2.0-85180070417"
-"White M.; Thomas A.; Aston M.; Joy P.","White, Megan (57469663900); Thomas, Andrew (57763228700); Aston, Megan (7004682224); Joy, Phillip (56533506900)","57469663900; 57763228700; 7004682224; 56533506900","“It’s beautiful and it’s messy and it’s tragic”: exploring the role of compassion in the eating disorder recovery processes of 2S/LGBTQ + Canadians","2024","Journal of Eating Disorders","12","1","23","","","","","10.1186/s40337-024-00981-6","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184868411&doi=10.1186%2fs40337-024-00981-6&partnerID=40&md5=b79b3c4a548e620d4ea0ea478b1f09c1","This research explores experiences of compassion among 2S/LGBTQ + Canadians living with eating disorders in the context of eating disorder treatment and community support. There is a growing body of scholarship showing disparities in eating disorder care for those within 2S/LGBTQ + communities. Among the reported concerns is a potential lack of compassion in eating disorder treatment and recovery settings, something which may serve to exacerbate feelings of isolation and perpetuate misunderstandings of 2S/LGBTQ + people’s experiences. In an effort to understand these dynamics more deeply, we conducted semi-structured interviews with 2S/LGBTQ + Canadians who have experienced eating disorder care. The data collected were then subjected to Foucauldian discourse analysis, which produced three interconnected discursive considerations: feeling lack of structural compassion, 2S/LGBTQ + communities as places of respite, and 2S/LGBTQ + caregiving. One of the common threads among these discursive considerations was cis-heteronormativity ingrained in eating disorder treatment settings and health care systems more broadly. Our findings underscore the critical need for more enhanced compassion for 2S/LGBTQ + patients in eating disorder care settings. We conclude that compassion, when implemented on the levels of individual clinicians, policy and procedure, and institutions, may represent an avenue toward disrupting ingrained cis-heteronormativity and the associated discursive power structures contained in health care systems. © The Author(s) 2024.","2S/LGBTQ +; Compassion; Eating disorders; Foucauldian discourse analysis; Gender minorities; Poststructuralism; Sexual minorities","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184868411"
-"Eyles H.; Dodd S.; Garton K.K.; Jiang Y.; de Castro T.G.","Eyles, Helen (24504132100); Dodd, Sah (58783481900); Garton, Kelly K. (57191023817); Jiang, Yannan (13104403400); de Castro, Teresa Gontijo (36780235600)","24504132100; 58783481900; 57191023817; 13104403400; 36780235600","New Zealand household purchases of sugar-sweetened, artificially sweetened, and unsweetened beverages: 2015–2019","2024","Public Health Nutrition","27","1","2300279","","","","0","10.1017/S1368980023002793","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180777233&doi=10.1017%2fS1368980023002793&partnerID=40&md5=5e7241a9f44127728eacae5bd80a5baf","Objective: To assess annual household purchases of sugar-sweetened beverages (SSBs), artificially sweetened beverages (AFSBs), and unsweetened beverages (USBs) by household composition and income, and over time. Design: Observational cohort study using beverage purchasing data linked to a supermarket database. ANOVA was used to compare total household purchase volumes (L) and the contribution of beverages purchased by category, household composition (size), household income (four categories from New Zealand (NZ) < $30 000 to > $90 000), and over time (trend from 2015 to 2019). Setting: Aotearoa NZ. Participants: ∼1800 households in the NielsenIQ Homescan® market research panel. Results: In 2019, the mean (SD) annual household purchase volume and relative contribution to total beverage volume of SSBs were 72·3 (93·0) L and 33 %, respectively. Corresponding values for AFSBs were 32·5 (79·3) L (15 %), and USBs were 112·5 (100·9) L (52 %). Larger households purchased more of all beverage types except AFSBs. Total purchases were similar by income, but households earning < $NZ 30 000 purchased fewer AFSBs and USBs (but not SSBs) than households earning > $NZ 90 000. Total and USB purchases were unchanged over time, but SSBs dropped by 5·9 L (P-trend = 0·04), and AFSBs increased by 5·3 L (P-trend = 0·00). Conclusions: USBs contributed the most to household beverage purchases. Total purchases were higher for larger households and similar by income, including for SSBs. The reduction over time was too small for health benefits. Findings support policies and interventions to reduce SSB consumption and highlight the importance of focusing on equitable outcomes. © The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society.","Beverages; Household purchasing; Monitoring; Sugar; Sweeteners","Beverages; Consumer Behavior; Humans; New Zealand; Sugars; Sweetening Agents; carbohydrate; sweetening agent; beverage; consumer attitude; human; New Zealand","Article","Final","","Scopus","2-s2.0-85180777233"
-"Amin F.; Imran M.; Hafeez S.A.; Zehra B.","Amin, Faridah (57209064217); Imran, Muhammad (57216889328); Hafeez, Syed Asif (58762665000); Zehra, Beenish (58763277200)","57209064217; 57216889328; 58762665000; 58763277200","Diabetes and its associated factors: A Retrospective cohort analysis of a large database at Indus Hospital Health Network","2024","Pakistan Journal of Medical Sciences","40","2","","S10","S14","4","1","10.12669/pjms.40.2(ICON).8948","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85178931180&doi=10.12669%2fpjms.40.2%28ICON%29.8948&partnerID=40&md5=936f87a95dcbb188ac2ebc7afc5f3097","Objectives: This is a retrospective cohort analysis of diabetes and its associated factors from Electronic Medical Record (EMR) of 2020-2022 of Indus Hospital Health Network (IHHN), Korangi campus Karachi. Methods: Retrospective cohort study was conducted at Indus Hospital & Health Network (IHHN), Korangi Karachi. Out-patient records of adult patients of 2020-2022 were extracted from EMR of IHHN in March 2023. Descriptive statistics were presented as median (IQR) and frequency and percentage. Chi-square test determined association of risk-factors with diabetes and Wilcoxon-sign-rank test compared change in HbA1C from baseline. Results: Data of 460,799 adult patients were extracted and analyzed. Median age of patients was 38.71 (27.8752) years. Female preponderance was observed in our study. Out of 460,799, HbA1C was seen in 42,638 (9.25%) patients. Among these 29,596 (69.4%) had a HbA1C ≥ 6.5% while 13,042 (30.6%) had a HbA1C in the pre-diabetes range. Significant association was found between age, baseline creatinine, LDL and diabetes with no association depicted between gender, BMI, blood pressure, triglycerides, HDL and diabetes status. Patients in general had higher HbA1C at baseline as compared to last visit (p-value<0.001). Conclusion: High blood pressure, obesity, increased creatinine, micro albuminurea, high LDL and Triglycerides were important risk factors for diabetes. This study reports a snap shot of the status of diabetes and associated risk-factors in the Pakistani population. This was the first time that a large data was extracted and analyzed from a healthcare institution in Pakistan, which would guide physicians and public health practitioners to take evidence-based decisions for prevention and management of diabetes. © 2024, Professional Medical Publications. All rights reserved.","Diabetes in Pakistan; diabetes registry Pakistan; NCD registry Pakistan; Non-communicable diseases in Pakistan","creatinine; hemoglobin A1c; high density lipoprotein; low density lipoprotein; triacylglycerol; adult; aged; Article; artificial intelligence; blood pressure; body mass; cardiovascular risk factor; cohort analysis; controlled study; descriptive research; diabetes mellitus; diabetic patient; disease association; electronic medical record; evidence based practice; female; follow up; human; major clinical study; male; obesity; Pakistani; retrospective study; risk factor; Wilcoxon signed ranks test","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85178931180"
-"Yang L.; Liu X.; Peng Z.; Liu Z.; Song P.; Zhou J.; Ma K.; Yu Y.; Dong Q.","Yang, Luchen (57212275817); Liu, Xiaoyang (57678664800); Peng, Zhufeng (56413726400); Liu, Zhenghuan (57211442415); Song, Pan (57194240217); Zhou, Jing (58385734100); Ma, Kai (58881576100); Yu, Yunfei (58575240600); Dong, Qiang (57196865385)","57212275817; 57678664800; 56413726400; 57211442415; 57194240217; 58385734100; 58881576100; 58575240600; 57196865385","Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer","2024","BMC Public Health","24","1","430","","","","","10.1186/s12889-024-17801-w","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184794661&doi=10.1186%2fs12889-024-17801-w&partnerID=40&md5=5289f1a7f3c5f2e63f3c099b27169f17","Cancer is a major socioeconomic burden that seriously affects the life and spirit of patients. However, little is known about the role of environmental toxicant exposure in diseases, especially ubiquitous di-(2-ethylhexyl) phthalate (DEHP) which is one of the most widely used plasticizers. Hence, the objective of this study was to assess the potential association between cancer and DEHP. The data were collected using the 2011–2018 National Health and Nutrition Examination Survey (NHANES) data (n = 6147), and multiple logistic regression was conducted to evaluate the association. The concentrations of DEHP were calculated by each metabolite and split into quartiles for analysis. After adjusting for confounding factors, DEHP was significantly associated with an increased risk of cancer prevalence, and the metabolites of DEHP showed similar results (OR > 1.0, p < 0.05). Simultaneously, the association remained when the analyses were stratified by age and sex, and the risk of cancer appeared to be higher in male patients. In addition, further analysis suggested that DEHP exposure obviously increased the risk of female reproductive system cancer, male reproductive system cancer, and other cancers (OR > 1.0, p < 0.05) but not skin and soft tissue cancer. DEHP exposure is associated with the risk of cancer, especially female reproductive system cancer, male reproductive system cancer and other cancers. © The Author(s) 2024.","Cancer; Di-(2-ethylhexyl) phthalate (DEHP); Epidemiology; Metabolites; NHANES","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184794661"
-"Vasudev A.; Ionson E.; Sathiaselan J.; Thatipalli A.; Chauhan A.; Hassan C.; Sukhera J.; Speechley M.; Forchuk C.","Vasudev, Akshya (15023372200); Ionson, Emily (57194392294); Sathiaselan, Janani (57914080000); Thatipalli, Anurag (57968450600); Chauhan, Aman (57968137700); Hassan, Christine (58885508000); Sukhera, Javeed (32267639600); Speechley, Mark (7004424767); Forchuk, Cheryl (34770046900)","15023372200; 57194392294; 57914080000; 57968450600; 57968137700; 58885508000; 32267639600; 7004424767; 34770046900","A feasibility (pilot) mixed methods study of an innovative non-pharmacological breath-based yoga and social-emotional intervention program in an at-risk youth sample in London, Canada","2024","Pilot and Feasibility Studies","10","1","26","","","","","10.1186/s40814-024-01452-0","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184899721&doi=10.1186%2fs40814-024-01452-0&partnerID=40&md5=63587c0ec62c1277217818ea3d76d5b0","Background: Various service provision models for youth at risk of homelessness have been researched and implemented, including access to housing and physical and mental health resources. However, even with these interventions, we remain unaware of how best to manage symptoms of depression and anxiety and the rate of drug use in these populations primarily because of a lack of feasibility data. Methods: This paper presents the results of a mixed-methods study in London, Canada, that examined the feasibility of implementing a biopsychosocial intervention, SKY Schools, in at-risk youth aged between 16 and 25 (n = 49). The study also recorded qualitative responses about the program’s usefulness from the perspective of the service users. The SKY Schools intervention consisted of social-emotional learning combined with Sudarshan Kriya Yoga, a standardized yoga-based breathing exercise routine. The intervention program was divided into two phases: an active learning phase and a reinforcement phase. The following feasibility outcome measures were collected: (1) the number of potential participants approached per month, (2) number (proportion) who were successfully screened, (3) the proportion of screened participants who enrolled, (4) the rate of retention in the study, (5) rate of adherence to study protocol, (6) proportion of planned ratings that were completed, (7) intervention cost per case, (8) completeness of final data for analysis, (9) length of time to collect all data, (10) quality of all collected data, (11) determining if partnering community organizations were willing to conduct the study as per study protocol, (12) determining if there were any capacity issues with partners providing intervention and investigators being able to perform the tasks that they were committed to doing, (13) determining if there were any problems of entering the data into a computer, (14) preliminary data about the safety of the intervention, and (15) preliminary estimate of treatment effects. Results: All feasibility outcome measures were collectible. In the city of London, Canada it was feasible to conduct a pilot study in this population of youth at risk of homelessness. Foremost among the findings was a high retention rate (61.2%) and overall positive qualitative feedback with a number of potential suggestions to improve the delivery and quality of the intervention. However, we had a significantly low recruitment rate (0.27 participants per week) suggesting that multiple sites will be needed to achieve an adequate sample size for a subsequent definitive trial. Conclusions: Future researchers may consider the findings of this feasibility study when designing a randomized control trial to further assess the efficacy and tolerability of SKY Schools. Trial registration: Trial registration: Clinicaltrials.gov, identifier NCT02749240. Registered April 22, 2016, https://clinicaltrials.gov/ct2/show/NCT02749240. © The Author(s) 2024.","Depression; Homeless; Mental health; Yoga; Youth at-risk","","Article","Final","All Open Access; Gold Open Access; Green Open Access","Scopus","2-s2.0-85184899721"
-"Pourtaheri A.; Mahdizadeh M.; Tehrani H.; Jamali J.; Peyman N.","Pourtaheri, Asma (57264716300); Mahdizadeh, Mehrsadat (55547416900); Tehrani, Hadi (57132467100); Jamali, Jamshid (55030415500); Peyman, Nooshin (26535061800)","57264716300; 55547416900; 57132467100; 55030415500; 26535061800","Socio-ecological factors of girl child marriage: a meta-synthesis of qualitative research","2024","BMC Public Health","24","1","428","","","","","10.1186/s12889-023-17626-z","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184788026&doi=10.1186%2fs12889-023-17626-z&partnerID=40&md5=06b32867f83d2c8a45cde2788e711b3b","Background: Child marriage of girls is one example of human rights violations, and is increasingly recognized as a key obstacle to global public health. Given the importance of a comprehensive understanding of the motivations for child marriage, this study aimed to identify socio-ecological factors contributing to gills child marriage. Methods: A comprehensive search was conducted of all English-language studies measuring causes of child marriage between 2000 and October 2022 in the Web of Science, PubMed, Scopus, PsycInfo, ProQuest, Poplin and Google Scholar databases. Girl child marriage is defined as a marriage under the age of 18. In this study, the CASP evaluation checklist was used to collect data. Two independent reviewers reviewed all articles. Results: A total of 34 eligible qualitative articles were included. The most salient causes of child marriage among girls include low skills and knowledge, internal and external beliefs and motivations, and physical advantages at the individual level. Family characteristics and structure contribute to child marriage at the interpersonal level, while environmental and economic factors play a role at the community level. Social factors and cultural norms, as well as the shortcomings and weaknesses of legislation, are also contributing factors at the society level. Conclusion: The results showed that cultural beliefs supporting gender inequality and economic status were the most important causes of child marriage. These results can help policymakers and decision-makers implement strategies to reduce gender inequality to prevent child marriage. © The Author(s) 2024.","Child marriage; Meta-synthesis; Qualitative research","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184788026"
-"Wang X.-A.; Li J.-P.; Lee M.-S.; Yang S.-F.; Chang Y.-S.; Chen L.; Li C.-W.; Chao Y.-H.","Wang, Xing-An (57212218630); Li, Ju-Pi (58881648300); Lee, Maw-Sheng (58881599800); Yang, Shun-Fa (58881624800); Chang, Yi-Sheng (58513922800); Chen, Ling (58514604200); Li, Chang-Wei (58514148400); Chao, Yu-Hua (7402865774)","57212218630; 58881648300; 58881599800; 58881624800; 58513922800; 58514604200; 58514148400; 7402865774","A common trajectory of gut microbiome development during the first month in healthy neonates with limited inter-individual environmental variations","2024","Scientific Reports","14","1","3264","","","","","10.1038/s41598-024-53949-6","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184791704&doi=10.1038%2fs41598-024-53949-6&partnerID=40&md5=79ff8837e27e56e51ac3bb5e7ea287ab","The early development of the gut microbiome is governed by multiple factors and has significantly long-term effects on later-in-life health. To minimize inter-individual variations in the environment, we determined developmental trajectories of the gut microbiome in 28 healthy neonates during their stay at a postpartum center. Stool samples were collected at three time points: the first-pass meconium within 24 h of life, and at 7 and 28 days of age. Illumina sequencing of the V3–V4 region of 16S rRNA was used to investigate microbiota profiles. We found that there was a distinct microbiota structure at each time point, with a significant shift during the first week. Proteobacteria was most abundant in the first-pass meconium; Firmicutes and Actinobacteria increased with age and were substituted as the major components. Except for a short-term influence of different delivery modes on the microbiota composition, early microbiome development was not remarkably affected by gravidity, maternal intrapartum antibiotic treatment, premature rupture of membranes, or postnatal phototherapy. Hence, our data showed a similar developmental trajectory of the gut microbiome during the first month in healthy neonates when limited in environmental variations. Environmental factors external to the host were crucial in the early microbiome development. © The Author(s) 2024.","","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184791704"
-"Testa L.; Richardson L.; Cheek C.; Hensel T.; Austin E.; Safi M.; Ransolin N.; Carrigan A.; Long J.; Hutchinson K.; Goirand M.; Bierbaum M.; Bleckley F.; Hibbert P.; Churruca K.; Clay-Williams R.","Testa, Luke (57192239187); Richardson, Lieke (58325059500); Cheek, Colleen (55445845600); Hensel, Theresa (58881629900); Austin, Elizabeth (56037611300); Safi, Mariam (57466387300); Ransolin, Natália (57216964127); Carrigan, Ann (57207690983); Long, Janet (55667633700); Hutchinson, Karen (57216987397); Goirand, Magali (57247748900); Bierbaum, Mia (57195994041); Bleckley, Felicity (58881556700); Hibbert, Peter (8941534500); Churruca, Kate (57193885924); Clay-Williams, Robyn (23479410700)","57192239187; 58325059500; 55445845600; 58881629900; 56037611300; 57466387300; 57216964127; 57207690983; 55667633700; 57216987397; 57247748900; 57195994041; 58881556700; 8941534500; 57193885924; 23479410700","Strategies to improve care for older adults who present to the emergency department: a systematic review","2024","BMC Health Services Research","24","1","178","","","","","10.1186/s12913-024-10576-1","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184790736&doi=10.1186%2fs12913-024-10576-1&partnerID=40&md5=2206f537df39e3f109cae4c37a6fc600","Background: The aim of this systematic review was to examine the relationship between strategies to improve care delivery for older adults in ED and evaluation measures of patient outcomes, patient experience, staff experience, and system performance. Methods: A systematic review of English language studies published since inception to December 2022, available from CINAHL, Embase, Medline, and Scopus was conducted. Studies were reviewed by pairs of independent reviewers and included if they met the following criteria: participant mean age of ≥ 65 years; ED setting or directly influenced provision of care in the ED; reported on improvement interventions and strategies; reported patient outcomes, patient experience, staff experience, or system performance. The methodological quality of the studies was assessed by pairs of independent reviewers using The Joanna Briggs Institute critical appraisal tools. Data were synthesised using a hermeneutic approach. Results: Seventy-six studies were included in the review, incorporating strategies for comprehensive assessment and multi-faceted care (n = 32), targeted care such as management of falls risk, functional decline, or pain management (n = 27), medication safety (n = 5), and trauma care (n = 12). We found a misalignment between comprehensive care delivered in ED for older adults and ED performance measures oriented to rapid assessment and referral. Eight (10.4%) studies reported patient experience and five (6.5%) reported staff experience. Conclusion: It is crucial that future strategies to improve care delivery in ED align the needs of older adults with the purpose of the ED system to ensure sustainable improvement effort and critical functioning of the ED as an interdependent component of the health system. Staff and patient input at the design stage may advance prioritisation of higher-impact interventions aligned with the pace of change and illuminate experience measures. More consistent reporting of interventions would inform important contextual factors and allow for replication. © The Author(s) 2024.","Complex system; Indicators; Patient safety; Quality; Urgent healthcare; Value-based care","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184790736"
-"Wu S.-I.; Huang Y.-H.; Kao K.-L.; Lin Y.-W.; Tsai P.-L.; Chiu N.-C.; Chung C.-H.; Chen C.-P.","Wu, Shu-I (57221213379); Huang, Yu-Hsin (7501574575); Kao, Kai-Liang (35337005200); Lin, Yu-Wen (58139312700); Tsai, Po-Li (57164324400); Chiu, Nan-Chang (58884854700); Chung, Ching-Hu (35721670900); Chen, Chie-Pein (56259170100)","57221213379; 7501574575; 35337005200; 58139312700; 57164324400; 58884854700; 35721670900; 56259170100","Psychiatric disorders in term-born children with marginally low birth weight: a population-based study","2024","Child and Adolescent Psychiatry and Mental Health","18","1","23","","","","","10.1186/s13034-024-00714-2","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184917155&doi=10.1186%2fs13034-024-00714-2&partnerID=40&md5=207166a4dfb7ceda67e53a7341808c85","Background: Marginally low birth weight (MLBW) is defined as a birth weight of 2000 ~ 2499 g. Inconsistent findings have been reported on whether children with low birth weight had higher rates of neurological, attention, or cognitive symptoms. No studies have explored the occurrence of clinically diagnosed psychiatric disorders in term- born MLBW infants. We aimed to investigate the risk of subsequent psychiatric disorders in term-born children with MLBW. Methods: This is a nationwide retrospective cohort study, by analysing the data from Taiwan’s National Health Insurance Research Database from 2008 to 2018. The study population includes propensity-score-matched term-born infants with MLBW and those without MLBW (birth weight ≥ 2500 g). Cox proportional hazard analysis was used after adjustment for potential demographic and perinatal comorbidity confounders. Incidence rates and hazard ratios (HR) of 11 psychiatric clinical diagnoses were evaluated. Results: A total of 53,276 term-born MLBW infants and 1,323,930 term-born infants without MLBW were included in the study. After propensity score matching for demographic variables and perinatal comorbidities, we determined that the term-born MLBW infants (n = 50,060) were more likely to have attention deficit and hyperactivity disorder (HR = 1.26, 95% confidence interval (CI) [1.20, 1.33]), autism spectrum disorder (HR = 1.26, 95% CI [1.14, 1.40]), conduct disorder (HR = 1.25, 95% CI [1.03, 1.51]), emotional disturbance (HR: = 1.13, 95% CI [1.02, 1.26]), or specific developmental delays (HR = 1.38, 95% CI [1.33, 1.43]) than term-born infants without MLBW (n = 50,060). Conclusion: MLBW was significantly associated with the risk of subsequent psychiatric disorder development among term-born infants. The study findings demonstrate that further attention to mental health and neurodevelopment issues may be necessary in term-born children with MLBW. However, possibilities of misclassification in exposures or outcomes, and risks of residual and unmeasured confounding should be concerned when interpreting our data. © The Author(s) 2024.","ADHD; Autism; Emotional disturbance; Marginally low birth weight; Psychiatric disorder","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184917155"
-"Terheyden J.H.; Fink D.J.; Mercieca K.; Wintergerst M.W.M.; Holz F.G.; Finger R.P.","Terheyden, Jan Henrik (57192206243); Fink, David J. (57337059900); Mercieca, Karl (18037783000); Wintergerst, Maximilian W. M. (56324659500); Holz, Frank G. (57201820304); Finger, Robert P. (25926257600)","57192206243; 57337059900; 18037783000; 56324659500; 57201820304; 25926257600","Knowledge about age-related eye diseases in the general population in Germany","2024","BMC Public Health","24","1","409","","","","","10.1186/s12889-024-17889-0","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184786087&doi=10.1186%2fs12889-024-17889-0&partnerID=40&md5=be23199be7f1287942cf525a3e8699bf","Background: With a rising prevalence of age-related eye diseases, prevention and early diagnosis of these conditions are key goals of public eye health. Disease-related knowledge in the general public supports these goals but there is little data available. Thus, we have assessed knowledge of cataract, glaucoma, age-related macular degeneration (AMD) and diabetic eye disease in the German adult general population in a cross-sectional study and identified target groups for health education interventions. Methods: Knowledge assessment content was identified based on a literature review, expert input, and a list of items was generated after a qualitative selection process. The resulting 16-item instrument (4 items per condition) was administered to 1,008 participants from a survey panel, demographically representative of the adult German population. Test properties were evaluated based on a Rasch model and multiple correspondence analysis (MCA). Binary-logistic regression analysis was performed to investigate associations with age, sex, education level, employment status, marital status, income, reported health status, visual difficulties, and recent general practitioner (GP) and ophthalmologist consultations. Results: Replies were correct for a median of 9 out of 16 (range 2 – 16) items, which differed between conditions (p < 0.0001). Most responses were correct for cataract items (median: 3 / 4) and least were correct for AMD items (median: 2 / 4). 27%, 9%, 1% and 19% of respondents replied correctly to all cataract, glaucoma, AMD and diabetic eye disease-related items, respectively. Rasch analysis suggested an adequate targeting of items and in MCA, no evidence of multidimensionality was present. Older age, being retired, decreased general health and recent GP or ophthalmology consultations were significantly associated with more knowledge about common eye conditions (p ≤ 0.005). GP or ophthalmology consultations remained significant in a multivariable model (p ≤ 0.011). Conclusions: Knowledge gaps regarding eye health are considerable in the German general population and should therefore be addressed in educational interventions targeting the public. Special attention when designing such campaigns needs to be paid to infrequent users of the healthcare system. Knowledge of AMD seems to be poorer compared to other eye conditions. © The Author(s) 2024.","Age-related macular degeneration; Cataract; Diabetic eye disease; Glaucoma; Health literacy","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184786087"
-"Greenwell J.; Grant M.; Young L.; Mackay S.; Bradbury K.E.","Greenwell, James (56880024600); Grant, Megan (58757290200); Young, Leanne (57193323844); Mackay, Sally (53984560700); Bradbury, Kathryn Erica (57210673942)","56880024600; 58757290200; 57193323844; 53984560700; 57210673942","The prevalence of vegetarians, vegans and other dietary patterns that exclude some animal-source foods in a representative sample of New Zealand adults","2024","Public Health Nutrition","27","1","e5","","","","0","10.1017/S1368980023002677","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85179385589&doi=10.1017%2fS1368980023002677&partnerID=40&md5=66a8e7512026f5ca1cb343438918dd13","Objective: This study aimed to estimate the prevalence of vegetarians, vegans and other dietary patterns that exclude some animal-source foods in New Zealand adults. We also examined socio-demographic and lifestyle correlates of these dietary patterns. Design: The New Zealand Health Survey is a representative rolling cross-sectional survey of New Zealanders; data from the 2018/19 and 2019/20 waves were used for this analysis. Participants were asked if they completely excluded red meat, poultry, fish/shellfish, eggs or dairy products from their diet. Setting: New Zealand. Participants: Adults, aged ≥ 15 years (n 23 292). Results: The prevalence of red-meat excluders (2·89 %), pescatarians (1·40 %), vegetarians (2·04 %) and vegans (0·74 %) was low. After adjustment for socio-demographic and lifestyle factors, women (OR = 1·54, 95 % CI: 1·22, 1·95), Asian people (OR = 2·56, 95 % CI: 1·96, 4·45), people with tertiary education (OR = 1·71, 95 % CI: 1·18, 2·48) and physically active people (OR = 1·36, 95 % CI: 1·04, 1·76) were more likely to be vegetarian/vegan. Those aged ≥ 75 years (OR = 0·28, 95 % CI: 0·14, 0·53) and current smokers (OR = 0·42, 95 % CI: 0·23, 0·76) were less likely to be vegetarian/vegan. Similar associations were seen between socio-demographic and lifestyle factors and the odds of being a red-meat excluder/pescatarian. Conclusions: Approximately 93 % of New Zealand adults eat red meat and a very small number exclude all animal products from their diets. The Eating and Activity Guidelines for New Zealand adults recommend a plant-based diet with moderate amounts of animal-source foods. A comprehensive national nutrition survey would provide detailed information on the amount of red meat and other animal-source foods that the New Zealand population currently consumes.  © The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society.","Dietary patterns; New Zealand; Pescatarian; Prevalence; Red meat; Vegan; Vegetarian","Adult; Cross-Sectional Studies; Diet, Vegan; Diet, Vegetarian; Dietary Patterns; Humans; Meat; New Zealand; New Zealander people; Prevalence; adult; cross-sectional study; epidemiology; human; meat; New Zealand; prevalence; vegan diet; vegetarian diet","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85179385589"
-"Nopour R.","Nopour, Raoof (57220634861)","57220634861","Screening ovarian cancer by using risk factors: machine learning assists","2024","BioMedical Engineering Online","23","1","18","","","","0","10.1186/s12938-024-01219-x","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184951519&doi=10.1186%2fs12938-024-01219-x&partnerID=40&md5=55ab5d8a73aeec74b699fffcd5648c7a","Background and aim: Ovarian cancer (OC) is a prevalent and aggressive malignancy that poses a significant public health challenge. The lack of preventive strategies for OC increases morbidity, mortality, and other negative consequences. Screening OC through risk prediction could be leveraged as a powerful strategy for preventive purposes that have not received much attention. So, this study aimed to leverage machine learning approaches as predictive assistance solutions to screen high-risk groups of OC and achieve practical preventive purposes. Materials and methods: As this study is data-driven and retrospective in nature, we leveraged 1516 suspicious OC women data from one concentrated database belonging to six clinical settings in Sari City from 2015 to 2019. Six machine learning (ML) algorithms, including XG-Boost, Random Forest (RF), J-48, support vector machine (SVM), K-nearest neighbor (KNN), and artificial neural network (ANN) were leveraged to construct prediction models for OC. To choose the best model for predicting OC, we compared various prediction models built using the area under the receiver characteristic operator curve (AU-ROC). Results: Current experimental results revealed that the XG-Boost with AU-ROC = 0.93 (0.95 CI = [0.91–0.95]) was recognized as the best-performing model for predicting OC. Conclusions: ML approaches possess significant predictive efficiency and interoperability to achieve powerful preventive strategies leveraging OC screening high-risk groups. © The Author(s) 2024.","Machine learning; Ovarian cancer; Predictive efficiency; Preventive strategy; Public health challenge","Diseases; Forecasting; Forestry; Health risks; Learning systems; Nearest neighbor search; Neural networks; Public health; Support vector machines; Machine learning approaches; Machine-learning; Ovarian cancers; Prediction modelling; Predictive efficiency; Preventive strategies; Public health challenge; Risk factors; Risk groups; Risk predictions; Efficiency","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184951519"
-"Pei W.; Li Y.; Wen P.; Yang F.; Ji X.","Pei, Wei (57324599100); Li, Yan (57294903300); Wen, Peng (58850625400); Yang, Fuwen (58885718300); Ji, Xiaopeng (57701201500)","57324599100; 57294903300; 58850625400; 58885718300; 57701201500","An automatic method using MFCC features for sleep stage classification","2024","Brain Informatics","11","1","6","","","","","10.1186/s40708-024-00219-w","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184951916&doi=10.1186%2fs40708-024-00219-w&partnerID=40&md5=7300b489eeb5a1c5a4bbdf8dbe7aa990","Sleep stage classification is a necessary step for diagnosing sleep disorders. Generally, experts use traditional methods based on every 30 seconds (s) of the biological signals, such as electrooculograms (EOGs), electrocardiograms (ECGs), electromyograms (EMGs), and electroencephalograms (EEGs), to classify sleep stages. Recently, various state-of-the-art approaches based on a deep learning model have been demonstrated to have efficient and accurate outcomes in sleep stage classification. In this paper, a novel deep convolutional neural network (CNN) combined with a long short-time memory (LSTM) model is proposed for sleep scoring tasks. A key frequency domain feature named Mel-frequency Cepstral Coefficient (MFCC) is extracted from EEG and EMG signals. The proposed method can learn features from frequency domains on different bio-signal channels. It firstly extracts the MFCC features from multi-channel signals, and then inputs them to several convolutional layers and an LSTM layer. Secondly, the learned representations are fed to a fully connected layer and a softmax classifier for sleep stage classification. The experiments are conducted on two widely used sleep datasets, Sleep Heart Health Study (SHHS) and Vincent’s University Hospital/University College Dublin Sleep Apnoea (UCDDB) to test the effectiveness of the method. The results of this study indicate that the model can perform well in the classification of sleep stages using the features of the 2-dimensional (2D) MFCC feature. The advantage of using the feature is that it can be used to input a two-dimensional data stream, which can be used to retain information about each sleep stage. Using 2D data streams can reduce the time it takes to retrieve the data from the one-dimensional stream. Another advantage of this method is that it eliminates the need for deep layers, which can help improve the performance of the model. For instance, by reducing the number of layers, our seven layers of the model structure takes around 400 s to train and test 100 subjects in the SHHS1 dataset. Its best accuracy and Cohen’s kappa are 82.35% and 0.75 for the SHHS dataset, and 73.07% and 0.63 for the UCDDB dataset, respectively. © The Author(s) 2024.","Convolutional neural network; Long short-term memory; Mel-frequency cepstral coefficients; Sleep stages","Biomedical signal processing; Classification (of information); Convolution; Convolutional neural networks; Deep neural networks; Electrocardiograms; Electroencephalography; Frequency domain analysis; Sleep research; Statistical tests; 2 - Dimensional; Automatic method; Convolutional neural network; Data stream; Frequency domains; Health-study; Mel frequency cepstral co-efficient; Mel-frequency cepstral coefficients; Sleep stage; Sleep stages classifications; Long short-term memory","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184951916"
-"Shum M.H.-H.; Lee Y.; Tam L.; Xia H.; Chung O.L.-W.; Guo Z.; Lam T.T.-Y.","Shum, Marcus Ho-Hin (57216348525); Lee, Yang (58881035500); Tam, Leighton (58881315000); Xia, Hui (58881035600); Chung, Oscar Lung-Wa (58880605000); Guo, Zhihong (58881035700); Lam, Tommy Tsan-Yuk (56549450000)","57216348525; 58881035500; 58881315000; 58881035600; 58880605000; 58881035700; 56549450000","Binding affinity between coronavirus spike protein and human ACE2 receptor","2024","Computational and Structural Biotechnology Journal","23","","","759","770","11","","10.1016/j.csbj.2024.01.009","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184780903&doi=10.1016%2fj.csbj.2024.01.009&partnerID=40&md5=7a2dd06969b1b8dd1feecfb1dd28ecbd","Coronaviruses (CoVs) pose a major risk to global public health due to their ability to infect diverse animal species and potential for emergence in humans. The CoV spike protein mediates viral entry into the cell and plays a crucial role in determining the binding affinity to host cell receptors. With particular emphasis on α- and β-coronaviruses that infect humans and domestic animals, current research on CoV receptor use suggests that the exploitation of the angiotensin-converting enzyme 2 (ACE2) receptor poses a significant threat for viral emergence with pandemic potential. This review summarizes the approaches used to study binding interactions between CoV spike proteins and the human ACE2 (hACE2) receptor. Solid-phase enzyme immunoassays and cell binding assays allow qualitative assessment of binding but lack quantitative evaluation of affinity. Surface plasmon resonance, Bio-layer interferometry, and Microscale Thermophoresis on the other hand, provide accurate affinity measurement through equilibrium dissociation constants (KD). In silico modeling predicts affinity through binding structure modeling, protein-protein docking simulations, and binding energy calculations but reveals inconsistent results due to the lack of a standardized approach. Machine learning and deep learning models utilize simulated and experimental protein-protein interaction data to elucidate the critical residues associated with CoV binding affinity to hACE2. Further optimization and standardization of existing approaches for studying binding affinity could aid pandemic preparedness. Specifically, prioritizing surveillance of CoVs that can bind to human receptors stands to mitigate the risk of zoonotic spillover. © 2024 The Authors","Binding affinity; Coronavirus; Human ACE2; Receptor use; Spike protein","Animals; Binding energy; Cell membranes; Deep learning; Diseases; Dissociation; Enzymes; Equilibrium constants; Health risks; Surface plasmon resonance; Angiotensin-converting enzyme 2; Animal species; Binding affinities; Cell receptors; Coronaviruses; Global public health; Host cells; Human angiotensin-converting enzyme 2; Receptor use; Spike protein; Coronavirus","Short survey","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184780903"
-"Kalman J.L.; Burkhardt G.; Samochowiec J.; Gebhard C.; Dom G.; John M.; Kilic O.; Kurimay T.; Lien L.; Schouler-Ocak M.; Vidal D.P.; Wiser J.; Gaebel W.; Volpe U.; Falkai P.","Kalman, Janos L. (57202390022); Burkhardt, Gerrit (57216784775); Samochowiec, Jerzy (57212012731); Gebhard, Christian (57917434900); Dom, Geert (12768470700); John, Miriam (57205934276); Kilic, Ozge (55895132900); Kurimay, Tamas (25646350000); Lien, Lars (55246424900); Schouler-Ocak, Meryam (12040576600); Vidal, Diego Palao (58795139800); Wiser, Jan (58793942000); Gaebel, Wolfgang (12766622100); Volpe, Umberto (55933795400); Falkai, Peter (57210577818)","57202390022; 57216784775; 57212012731; 57917434900; 12768470700; 57205934276; 55895132900; 25646350000; 55246424900; 12040576600; 58795139800; 58793942000; 12766622100; 55933795400; 57210577818","Digitalising mental health care: Practical recommendations from the European Psychiatric Association","2024","European Psychiatry","67","1","e4","","","","0","10.1192/j.eurpsy.2023.2466","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181480165&doi=10.1192%2fj.eurpsy.2023.2466&partnerID=40&md5=58989146d187c40001c15a4e5e200dcf","The digitalisation of mental health care is expected to improve the accessibility and quality of specialised treatment services and introduce innovative methods to study, assess, and monitor mental health disorders. In this narrative review and practical recommendation of the European Psychiatric Association (EPA), we aim to help healthcare providers and policymakers to navigate this rapidly evolving field. We provide an overview of the current scientific and implementation status across two major domains of digitalisation: i) digital mental health interventions and ii) digital phenotyping, discuss the potential of each domain to improve the accessibility and outcomes of mental health services, and highlight current challenges faced by researchers, clinicians, and service users. Furthermore, we make several recommendations meant to foster the widespread adoption of evidence-based digital solutions for mental health care in the member states of the EPA. To realise the vision of a digitalised, patient-centred, and data-driven mental health ecosystem, a number of implementation challenges must be considered and addressed, spanning from human, technical, ethical-legal, and economic barriers. The list of priority areas and action points our expert panel has identified could serve as a playbook for this process.  © The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association.","digital mental health; digital mental health interventions; digital phenotyping; European Psychiatric Association; telepsychiatry","Ecosystem; Humans; Mental Disorders; Mental Health; Mental Health Services; digitalization; European; evidence based practice; health care personnel; human; mental health; mental health care; mental health service; phenotype; review; surgery; systematic review; telepsychiatry; ecosystem; mental disease; mental health; mental health service","Review","Final","All Open Access; Gold Open Access; Green Open Access","Scopus","2-s2.0-85181480165"
-"Selamoglu M.; Erbas B.; Wilson H.; Barton C.","Selamoglu, Melis (57429892300); Erbas, Bircan (57194821523); Wilson, Hester (57217317912); Barton, Chris (58879731600)","57429892300; 57194821523; 57217317912; 58879731600","‘Why do we have to be the gatekeepers?’ Australian general practitioners’ knowledge, attitudes and prescribing intentions on e-cigarettes as a smoking cessation aid","2024","BMC Primary Care","25","1","53","","","","","10.1186/s12875-024-02292-w","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184736939&doi=10.1186%2fs12875-024-02292-w&partnerID=40&md5=385907812ddc6d4a5b0a294fec56edca","Background: A significant policy change impacting the availability of nicotine for use in electronic cigarettes (e-cigarettes) in Australia took effect from October 1, 2021. This change meant that nicotine containing liquids for use with e-cigarettes would only be available by prescription from a medical practitioner as part of a smoking cessation plan. This study aimed to explore general practitioners (GPs) perceptions about the role of e-cigarettes, and understand factors informing their intentions to prescribe e-cigarettes as part of a smoking cessation plan. Methods: In-depth semi-structured interviews were conducted with thirteen GPs. Purposeful sampling was used to recruit participants. Interviews were audio recorded and transcribed verbatim. Thematic analysis was used to classify, describe and report themes in the data. QSR NVivo was used to aid coding, thematic analysis and retrieval of quotes. Results: Participants had diverse views on recommending and prescribing e-cigarettes as smoking cessation aids to patients. Some participants were willing to prescribe e-cigarettes to patients if other methods of smoking cessation had not worked but there were concerns, and uncertainty, about the safety and efficacy of e-cigarettes for smoking cessation. There was poor understanding of the current policy and legislation about e-cigarettes in Australia. Mostly the participants in this sample did not feel confident or comfortable to prescribe, or have discussions about e-cigarettes with patients. Conclusion: The participants of this study held diverse attitudes on recommending and prescribing e-cigarettes for smoking cessation. Clarity in guidelines and consumer product information are required to enable GPs to provide consistent and accurate advice to patients that wish to use e-cigarettes as a smoking cessation aid. © The Author(s) 2024.","e-cigarette; General practice; General practitioner; Primary care; Public health; Smoking cessation","","Article","Final","All Open Access; Gold Open Access; Green Open Access","Scopus","2-s2.0-85184736939"
-"Korman M.; Zarina D.; Tkachev V.; Merikanto I.; Bjorvatn B.; Bjelajac A.K.; Penzel T.; Landtblom A.-M.; Benedict C.; Chan N.Y.; Wing Y.K.; Dauvilliers Y.; Morin C.M.; Matsui K.; Nadorff M.; Bolstad C.J.; Chung F.; Mota-Rolim S.; De Gennaro L.; Plazzi G.; Yordanova J.; Holzinger B.; Partinen M.; Reis C.","Korman, Maria (8619656700); Zarina, Daria (58881560400); Tkachev, Vadim (57220816690); Merikanto, Ilona (37097612800); Bjorvatn, Bjørn (7006245692); Bjelajac, Adrijana Koscec (58742113600); Penzel, Thomas (57207902667); Landtblom, Anne-Marie (57196394994); Benedict, Christian (57207807345); Chan, Ngan Yin (58881704600); Wing, Yun Kwok (58725805600); Dauvilliers, Yves (7003647751); Morin, Charles M. (55575516900); Matsui, Kentaro (56597422200); Nadorff, Michael (36712113800); Bolstad, Courtney J. (57218526698); Chung, Frances (7202260652); Mota-Rolim, Sérgio (56015286600); De Gennaro, Luigi (57203437905); Plazzi, Giuseppe (7005146467); Yordanova, Juliana (7003703313); Holzinger, Brigitte (6602207727); Partinen, Markku (7007114725); Reis, Cátia (55821577400)","8619656700; 58881560400; 57220816690; 37097612800; 7006245692; 58742113600; 57207902667; 57196394994; 57207807345; 58881704600; 58725805600; 7003647751; 55575516900; 56597422200; 36712113800; 57218526698; 7202260652; 56015286600; 57203437905; 7005146467; 7003703313; 6602207727; 7007114725; 55821577400","Estimation bias and agreement limits between two common self-report methods of habitual sleep duration in epidemiological surveys","2024","Scientific Reports","14","1","3420","","","","","10.1038/s41598-024-53174-1","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184789886&doi=10.1038%2fs41598-024-53174-1&partnerID=40&md5=8ee7fab59065f6e721897d9fd339e0be","Accurate measurement of habitual sleep duration (HSD) is crucial for understanding the relationship between sleep and health. This study aimed to assess the bias and agreement limits between two commonly used short HSD self-report methods, considering sleep quality (SQ) and social jetlag (SJL) as potential predictors of bias. Data from 10,268 participants in the International COVID Sleep Study-II (ICOSS-II) were used. Method-Self and Method-MCTQ were compared. Method-Self involved a single question about average nightly sleep duration (HSDself), while Method-MCTQ estimated HSD from reported sleep times on workdays (HSDMCTQwork) and free days (HSDMCTQfree). Sleep quality was evaluated using a Likert scale and the Insomnia Severity Index (ISI) to explore its influence on estimation bias. HSDself was on average 42.41 ± 67.42 min lower than HSDMCTQweek, with an agreement range within ± 133 min. The bias and agreement range between methods increased with poorer SQ. HSDMCTQwork showed less bias and better agreement with HSDself compared to HSDMCTQfree. Sleep duration irregularity was − 43.35 ± 78.26 min on average. Subjective sleep quality predicted a significant proportion of variance in HSDself and estimation bias. The two methods showed very poor agreement and a significant systematic bias, both worsening with poorer SQ. Method-MCTQ considered sleep intervals without adjusting for SQ issues such as wakefulness after sleep onset but accounted for sleep irregularity and sleeping in on free days, while Method-Self reflected respondents’ interpretation of their sleep, focusing on their sleep on workdays. Including an SQ-related question in surveys may help bidirectionally adjust the possible bias and enhance the accuracy of sleep-health studies. © The Author(s) 2024.","","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184789886"
-"Faviez C.; Vincent M.; Garcelon N.; Boyer O.; Knebelmann B.; Heidet L.; Saunier S.; Chen X.; Burgun A.","Faviez, Carole (56728620000); Vincent, Marc (7402054873); Garcelon, Nicolas (24766002000); Boyer, Olivia (8509255100); Knebelmann, Bertrand (7004605792); Heidet, Laurence (6603840876); Saunier, Sophie (6602669382); Chen, Xiaoyi (57200255535); Burgun, Anita (7004335489)","56728620000; 7402054873; 24766002000; 8509255100; 7004605792; 6603840876; 6602669382; 57200255535; 7004335489","Performance and clinical utility of a new supervised machine-learning pipeline in detecting rare ciliopathy patients based on deep phenotyping from electronic health records and semantic similarity","2024","Orphanet Journal of Rare Diseases","19","1","55","","","","","10.1186/s13023-024-03063-7","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184792807&doi=10.1186%2fs13023-024-03063-7&partnerID=40&md5=0f1b4c1f7ca38fcef3fe0bd1be2a8cb1","Background: Rare diseases affect approximately 400 million people worldwide. Many of them suffer from delayed diagnosis. Among them, NPHP1-related renal ciliopathies need to be diagnosed as early as possible as potential treatments have been recently investigated with promising results. Our objective was to develop a supervised machine learning pipeline for the detection of NPHP1 ciliopathy patients from a large number of nephrology patients using electronic health records (EHRs). Methods and results: We designed a pipeline combining a phenotyping module re-using unstructured EHR data, a semantic similarity module to address the phenotype dependence, a feature selection step to deal with high dimensionality, an undersampling step to address the class imbalance, and a classification step with multiple train-test split for the small number of rare cases. The pipeline was applied to thirty NPHP1 patients and 7231 controls and achieved good performances (sensitivity 86% with specificity 90%). A qualitative review of the EHRs of 40 misclassified controls showed that 25% had phenotypes belonging to the ciliopathy spectrum, which demonstrates the ability of our system to detect patients with similar conditions. Conclusions: Our pipeline reached very encouraging performance scores for pre-diagnosing ciliopathy patients. The identified patients could then undergo genetic testing. The same data-driven approach can be adapted to other rare diseases facing underdiagnosis challenges. © The Author(s) 2024.","Diagnosis support; Electronic health record; Imbalanced dataset; Rare disease; Semantic similarity; Supervised machine learning","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184792807"
-"Nandi A.; Counts N.; Bröker J.; Malik S.; Chen S.; Han R.; Klusty J.; Seligman B.; Tortorice D.; Vigo D.; Bloom D.E.","Nandi, Arindam (55640067500); Counts, Nathaniel (57194524955); Bröker, Janina (58885313900); Malik, Sabrina (58884478600); Chen, Simiao (57203514169); Han, Rachael (58884478700); Klusty, Jessica (57862020700); Seligman, Benjamin (38062155400); Tortorice, Daniel (14025039700); Vigo, Daniel (26538354800); Bloom, David E. (26643254400)","55640067500; 57194524955; 58885313900; 58884478600; 57203514169; 58884478700; 57862020700; 38062155400; 14025039700; 26538354800; 26643254400","Cost of care for Alzheimer’s disease and related dementias in the United States: 2016 to 2060","2024","npj Aging","10","1","13","","","","","10.1038/s41514-024-00136-6","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184939460&doi=10.1038%2fs41514-024-00136-6&partnerID=40&md5=b65f8b198cca5f85cb1ed9b3137425c9","Medical and long-term care for Alzheimer’s disease and related dementias (ADRDs) can impose a large economic burden on individuals and societies. We estimated the per capita cost of ADRDs care in the in the United States in 2016 and projected future aggregate care costs during 2020–2060. Based on a previously published methodology, we used U.S. Health and Retirement Survey (2010–2016) longitudinal data to estimate formal and informal care costs. In 2016, the estimated per patient cost of formal care was $28,078 (95% confidence interval [CI]: $25,893–$30,433), and informal care cost valued in terms of replacement cost and forgone wages was $36,667 ($34,025–$39,473) and $15,792 ($12,980–$18,713), respectively. Aggregate formal care cost and formal plus informal care cost using replacement cost and forgone wage methods were $196 billion (95% uncertainty range [UR]: $179–$213 billion), $450 billion ($424–$478 billion), and $305 billion ($278–$333 billion), respectively, in 2020. These were projected to increase to $1.4 trillion ($837 billion–$2.2 trillion), $3.3 trillion ($1.9–$5.1 trillion), and $2.2 trillion ($1.3–$3.5 trillion), respectively, in 2060. © The Author(s) 2024.","","","Article","Final","All Open Access; Hybrid Gold Open Access","Scopus","2-s2.0-85184939460"
-"Cantú Quintanilla G.; Gómez-Guerrero I.E.; Aguiñaga-Chiñas N.; López Cervantes M.; Jaramillo Flores I.D.; Slon Rodríguez P.A.; Bravo Vargas C.F.; Arroyo-Valerio A.; García-Higuera M.D.C.","Cantú Quintanilla, Guillermo (36843684600); Gómez-Guerrero, Irma Eloisa (57191927883); Aguiñaga-Chiñas, Nuria (57667405400); López Cervantes, Mariana (58881650000); Jaramillo Flores, Ignacio David (58881675000); Slon Rodríguez, Pedro Alonso (58881718200); Bravo Vargas, Carlos Francisco (58881650100); Arroyo-Valerio, America (6507686958); García-Higuera, María del Carmen (58881697900)","36843684600; 57191927883; 57667405400; 58881650000; 58881675000; 58881718200; 58881650100; 6507686958; 58881697900","Perceptions of COVID-19 patients in the use of bioethical principles and the physician-patient relationship: a qualitative approach","2024","BMC Medical Ethics","25","1","16","","","","","10.1186/s12910-024-01009-z","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184794360&doi=10.1186%2fs12910-024-01009-z&partnerID=40&md5=3bcff6ef7ebac101bcf9273bdb6a9dd3","Background: The COVID-19 pandemic has influenced the approach to the health-disease system, raising the question about the principles of bioethics present in physician–patient relations. The principles while widely accepted may not be sufficient for a comprehensive ethical analysis. Therefore, the aim of this study was to explore the perception of these principles and the physician–patient relationship during a hospital stay through a qualitative approach. Method: Sixteen semi-structured interviews took place to know the patients’ perception during their 2020 hospitalization for COVID-19. The data was analyzed through the constant comparison method, creating categories and comparing them. In the end, seven categories were established and were grouped in three: bioethical principles (dignity, charity, vulnerability, autonomy), doctor-patient relationship (participant commitment, informed consent, health staff-patient relationship) and the experience of the disease (illness, the role of the family). Results: The research found that most patients described a positive experience, with the feeling of having been well cared for with no sense of discrimination or injustice done. The majority also reported that their autonomy was respected in the treatment decisions. The evaluation of these attitudes is an area of opportunity, especially when the patients' vulnerability is at risk. Conclusions: The ethics of virtue offers a better reflection of how human beings manifest themselves by emphasizing the development of virtuous character and behaviors that allow them to realize their values in life. Authorized by the Research Ethics Committee with registration: DI/18/105-B/3/308. © The Author(s) 2024.","Bioethics; COVID-19; Ethics of virtue; In-depth-interviews; Patients-perception; Physician–patient relationship","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184794360"
-"Strom J.B.; Song Y.; Jiang W.; Lou Y.; Pfeffer D.N.; Massad O.E.; Russo P.","Strom, Jordan B. (56158134300); Song, Yang (58879262800); Jiang, Wenting (58718783800); Lou, Yingbo (58719242000); Pfeffer, Daniel N. (57224199192); Massad, Omnya E. (58719016300); Russo, Pierantonio (58718783900)","56158134300; 58879262800; 58718783800; 58719242000; 57224199192; 58719016300; 58718783900","Validation of administrative claims to identify ultrasound enhancing agent use","2024","Echo Research and Practice","11","1","","","","","","10.1186/s44156-023-00038-5","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184736374&doi=10.1186%2fs44156-023-00038-5&partnerID=40&md5=1fce9ff983f7fd7a85e63409260cdca6","Background: Ultrasound enhancing agents (UEAs) are an invaluable adjunct to stress and transthoracic echocardiography (STE) to improve left ventricular visualization. Despite multiple single center studies evaluating UEA use, investigation into the rates, sources of variation, and outcomes of UEA use on a national level in the United States (US) has been limited by lack of validation of UEA codes for claims analyses. Methods: We conducted a retrospective cross-sectional study, 2019–2022, using linked multicenter electronic medical record (EMR) data from > 30 health systems linked to all-payor claims data representing > 90% of the US population. Individuals receiving STE in both EMR and claims data on the same day during the study window were included. UEA receipt as identified by presence of a Current Procedural Terminology (CPT) or National Drug Code (NDC) for UEA use within 1-day of the index STE event. We evaluated the performance of claims to identify UEA use, using EMR data as the gold standard, stratified by inpatient and outpatient status. Results: Amongst 54,525 individuals receiving STE in both EMR and claims data, 12,853 (23.6%) had a UEA claim in EMR, 10,461 (19.2%) had a UEA claim in claims, and 9140 (16.8%) had a UEA claim in both within the 1-day window. The sensitivity, specificity, accuracy, positive, and negative predictive values for UEA claims were 71.1%, 96.8%, 90.8%, 87.4%. and 91.6% respectively. However, amongst inpatients, the sensitivity of UEA claims was substantially lower (6.8%) compared to outpatients (79.7%). Conclusions: While the overall accuracy of claims to identify UEA use was high, there was substantial under-capture of UEA use by claims amongst inpatients. These results call into question published rates of UEA use amongst inpatients in studies using administrative claims, and highlight ongoing need to improve inpatient coding for UEA use. © The Author(s) 2024.","Administrative claims; Echocardiography; Ultrasound enhancing agents; Validation","","Article","Final","","Scopus","2-s2.0-85184736374"
-"Szabo S.M.; Hawkins N.S.; Germeni E.","Szabo, Shelagh M. (7202937674); Hawkins, Neil S. (7102710439); Germeni, Evi (25421932800)","7202937674; 7102710439; 25421932800","The extent and quality of qualitative evidence included in health technology assessments: A review of submissions to NICE and CADTH","2024","International Journal of Technology Assessment in Health Care","40","1","e6","","","","0","10.1017/S0266462323002829","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181022229&doi=10.1017%2fS0266462323002829&partnerID=40&md5=5c43c5a9a6dafb601ecc4157ab98aec0","Objectives Qualitative methods allow in-depth exploration of patient experiences and can provide context for healthcare decision making. Frameworks for patient-based evidence in health technology assessment (HTA) are expanding; yet, how extensively qualitative methods are currently used is unclear. This review characterized the extent and quality of qualitative data submitted to National Institute for Health and Care Excellence (NICE) and Canadian Agency for Drugs and Technologies in Health (CADTH) for HTA. Methods NICE and CADTH submissions from September 2019 to August 2021 were reviewed. Submission characteristics and features of patient-based evidence included within submissions were extracted. The quality of qualitative reporting was assessed using the CASP checklist. Results Patient-based evidence was included in 83/107 NICE and 119/124 CADTH submissions. A small proportion described qualitative data collection (NICE=14; CADTH=24) and analysis (NICE=6; CADTH=9) methods. One-to-one interviews were the most common data collection method, and thematic analysis was exclusively used. Thirty-three percent of NICE submissions scored >7 yes responses on CASP, versus 78 percent of CADTH submissions. Conclusions Although patient-based evidence was common in the submissions reviewed, only 14/107 NICE and 24/124 CADTH submissions involved formal qualitative data collection. Use of formal analysis methods was even rarer and reporting tended to be brief. At present, there is little guidance about qualitative evidence most likely to be informative and therefore to potentially impact decision making. Ensuring, however, that qualitative data are collected and analyzed in a systematic, rigorous way will maximize their usefulness and ensure that patient voices are clearly heard.  © The Author(s), 2023. Published by Cambridge University Press.","decision making; health policy; health technology assessment; patient-based evidence; qualitative research","Biomedical Technology; Canada; Cost-Benefit Analysis; Humans; Technology Assessment, Biomedical; Data acquisition; Health care; Common datum; Data collection; Decisions makings; Health technology assessments; Health-care decisions; Patient experiences; Patient-based evidence; Qualitative data; Qualitative method; Qualitative research; Article; biomedical technology assessment; data quality; human; information processing; medical decision making; medical information; patient attitude; patient based evidence; personal experience; publication; qualitative research; quality control; systematic review; thematic analysis; Canada; cost benefit analysis; medical technology; procedures; Decision making","Article","Final","","Scopus","2-s2.0-85181022229"
-"Lee C.J.; Kimball M.M.; Deussing E.C.; Kirsch T.D.","Lee, Clark J. (57829012300); Kimball, Michelle M. (57853466700); Deussing, Eric C. (43660996200); Kirsch, Thomas D. (7005854940)","57829012300; 57853466700; 43660996200; 7005854940","Use of Information Technology Systems for Regional Health Care Information-Sharing and Coordination during Large-Scale Medical Surge Events","2024","Disaster Medicine and Public Health Preparedness","18","1","e1","","","","0","10.1017/dmp.2023.218","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181528568&doi=10.1017%2fdmp.2023.218&partnerID=40&md5=99db4aa014dc48727ff7192f40066d15","Medical surge events require effective coordination between multiple partners. Unfortunately, the information technology (IT) systems currently used for information-sharing by emergency responders and managers in the United States are insufficient to coordinate with health care providers, particularly during large-scale regional incidents. The numerous innovations adopted for the COVID-19 response and continuing advances in IT systems for emergency management and health care information-sharing suggest a more promising future. This article describes: (1) several IT systems and data platforms currently used for information-sharing, operational coordination, patient tracking, and resource-sharing between emergency management and health care providers at the regional level in the US; and (2) barriers and opportunities for using these systems and platforms to improve regional health care information-sharing and coordination during a large-scale medical surge event. The article concludes with a statement about the need for a comprehensive landscape analysis of the component systems in this IT ecosystem.  © 2023 National Center for Disaster Medicine and Public Health, Uniformed Services University of the Health Sciences and the Author(s).","administrative; coordination; emergency responders; health care systems; information systems; mass casualty incidents","Delivery of Health Care; Disaster Planning; Ecosystem; Humans; Information Systems; Information Technology; Mass Casualty Incidents; Surge Capacity; United States; disaster planning; ecosystem; health care delivery; human; information system; information technology; mass disaster; surge capacity; United States","Article","Final","All Open Access; Hybrid Gold Open Access","Scopus","2-s2.0-85181528568"
-"Yu Y.; Gu F.; Luo Y.-L.; Li S.-G.; Jia X.-F.; Gu L.-X.; Zhang G.-P.; Liao X.","Yu, Yue (57764107100); Gu, Fang (58884060500); Luo, Yi-Lin (57208921717); Li, Shi-Guang (58884694900); Jia, Xiao-Feng (58885323800); Gu, Liang-Xian (58885323900); Zhang, Guo-Ping (58884275100); Liao, Xin (57210545877)","57764107100; 58884060500; 57208921717; 58884694900; 58885323800; 58885323900; 58884275100; 57210545877","The role of tumor parenchyma and brain cortex signal intensity ratio in differentiating solitary fibrous tumors and meningiomas","2024","Discover Oncology","15","1","32","","","","","10.1007/s12672-024-00883-8","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184888461&doi=10.1007%2fs12672-024-00883-8&partnerID=40&md5=af9be1bef2279ce3f83b295d39020bec","Background: Solitary fibrous tumors (SFT) and meningiomas (MA) have similar clinical and radiographic presentations but require different treatment approaches and have different prognoses. This emphasizes the importance of a correct preoperative diagnosis of SFT versus MA. Objective: In this study, investigated the differences in imaging characteristics between SFT and MA to improve the accuracy of preoperative imaging diagnosis of SFT. Methods: The clinical and imaging data of 26 patients with SFT and 104 patients with MA who were pathologically diagnosed between August 2017 and December 2022, were retrospectively analyzed. The clinical and imaging differences between SFT and MA, as well as between the various pathological grades of SFT, were analyzed. Results: Age, gender, cystic change, flow void phenomenon, yin-yang sign, lobulation, narrow base, tumor/cortex signal ratio (TCSR) > 1.0 in T1-weighted imaging (T1WI), TCSR ≥ 1.1 in T2-weighted imaging (T2WI), peritumoral edema, and absence of dural tail sign varied between SFT and MA. As per the receiver operating characteristic (ROC) curve analysis, TCSR > 1 in T1WI has the maximum diagnostic accuracy for SFT. Cranial or venous sinus invasion had a positive effect on SFT (Grade III, World Health Organization (WHO) grading). Conclusion: Among the many radiological and clinical distinctions between SFT and MA, TCSR ≥ 1 exhibits the highest predictive efficacy for SFT; while cranial or venous sinus invasion may be a predictor of WHO grade III SFT. © The Author(s) 2024.","Diagnosis; Differential diagnosis; Magnetic resonance imaging; Meningioma; Solitary fibrous tumor","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184888461"
-"Kidholm K.; Jensen L.K.; Johansson M.; Montori V.M.","Kidholm, Kristian (6505904513); Jensen, Lise Kvistgaard (57193139931); Johansson, Minna (56520896700); Montori, Victor M. (7005319198)","6505904513; 57193139931; 56520896700; 7005319198","Telemedicine and the assessment of clinician time: A scoping review","2024","International Journal of Technology Assessment in Health Care","40","1","e3","","","","0","10.1017/S0266462323002830","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180319526&doi=10.1017%2fS0266462323002830&partnerID=40&md5=0cb6b115929d9a537ef839be70d49c50","Objectives Telemedicine may improve healthcare access and efficiency if it demands less clinician time than usual care. We sought to describe the degree to which telemedicine trials assess the effect of telemedicine on clinicians' time and to discuss how including the time needed to treat (TNT) in health technology assessment (HTA) could affect the design of telemedicine services and studies. Methods We conducted a scoping review by searching clinicaltrials.gov using the search term telemedicine and limiting results to randomized trials or observational studies registered between January 2012 and October 2023. We then reviewed trial registration data to determine if any of the outcomes assessed in the trials measured effect on clinicians' time. Results We found 113 studies and of these 78 studies of telemedicine met the inclusion criteria and were included. Nine (12 percent) of the 78 studies had some measure of clinician time as a primary outcome, and 11 (14 percent) as a secondary outcome. Four studies compared direct measures of TNT with telemedicine versus usual care, but no statistically significant difference was found. Of the sixteen studies including indirect measures of clinician time, thirteen found no significant effects, two found a statistically significant reduction, and one found a statistically significant increase. Conclusions This scoping review found that clinician time is not commonly measured in studies of telemedicine interventions. Attention to telemedicine's TNT in clinical studies and HTAs of telemedicine in practice may bring attention to the organization of clinical workflows and increase the value of telemedicine.  © The Author(s), 2023. Published by Cambridge University Press.","clinician time; digital technologies; organisational impact; telemedicine; workload","Telemedicine; Comparison group; Direct measures; Healthcare access; Indirect measure; Observational study; Randomized trial; Scoping review; Search terms; Statistically significant difference; Telemedicine services; Article; biomedical technology assessment; clinician; health care; health service; hospital readmission; human; length of stay; telemedicine; time factor; time to treatment; workflow; procedures; Telemedicine","Article","Final","","Scopus","2-s2.0-85180319526"
-"Dehghani A.","Dehghani, Ali (58685160900)","58685160900","Association between health literacy with stress, anxiety and depression in multiple sclerosis patients: A cross sectional analytical study","2024","Acta neurologica Taiwanica","33(4)","","","146","152","6","0","","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85177793928&partnerID=40&md5=9c84a7d9e353874406dc6ee37539f198","OBJECTIVE: Multiple sclerosis is one of the diseases of the central nervous system, which causes numerous physical and mental problems. Since stress, anxiety and depression are effective in various dimensions of chronic diseases management and considering that health literacy plays a decisive role in the quality of life of these patients. Therefore, this study was conducted with the aim of determining the association between health literacy and stress, anxiety and depression. MATERIALS AND METHODS: The current research is a cross-sectional analytical study that was conducted with the participation of 164 patient's from the MS society of Jahrom city with convenience sampling. The data collection tool was the health literacy questionnaire of multiple sclerosis patients and a 21-question stress, anxiety and depression questionnaire. SPSS - 21 software, descriptive statistics and spearman and chi-square tests were used to analyze the data. RESULTS: The findings showed that the majority of patients had a borderline health literacy (53.7%). 43.3% of patients had adequate level of health literacy. Also, the findings showed that the stress, anxiety and depression levels of the majority of patients were moderate. Spearman's test showed that there is a negative and significant correlation between health literacy and stress in multiple sclerosis patients (p=0.03) (r=-0.37). While there was no significant correlation between health literacy and anxiety and depression of patients. CONCLUSION: The findings showed that with the increase in the health literacy, the rate of stress in patient's decreases.","Anxiety; Depression Multiple sclerosis.; Health literacy; Stress","adult; anxiety; article; borderline state; chi square distribution; chronic disease; convenience sample; cross-sectional study; data analysis software; depression; epidemiology; female; health literacy; human; major clinical study; male; middle aged; multiple sclerosis; physiological stress; quality of life; questionnaire","Article","Final","","Scopus","2-s2.0-85177793928"
-"Algahtani H.A.; Shirah B.H.; Albeladi Y.K.; Albeladi R.K.","Algahtani, Hussein A. (55663941000); Shirah, Bader H. (57190018390); Albeladi, Yazeed K. (57787495800); Albeladi, Reyadh K. (58265118400)","55663941000; 57190018390; 57787495800; 58265118400","Perception of Neurologists on Intraoperative Neurophysiological Monitoring in Saudi Arabia","2024","Acta neurologica Taiwanica","33(4)","","","161","164","3","0","","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85177893462&partnerID=40&md5=8f1e308a5558a2d6d75d5db58ed7dfdb","OBJECTIVE: Intraoperative neurophysiological monitoring (IONM) has the advantage of minimizing intraoperative neurological injury and limiting serious postoperative complications. No previous studies have evaluated the importance of IONM, especially in Gulf and Arab countries. We aimed to investigate the importance of IONM, as evaluated from a neurologist perspective in Saudi Arabia. METHODS: This cross-sectional study was conducted in Saudi Arabia through face-to-face interviews. The inclusion criterion was adult neurology consultants in Saudi Arabia. The instrument used was a self-administered questionnaire consisting of 20 items to evaluate the perceptions on IONM. Data collection was from January 2022 to June 2022. RESULTS: A total of 72 neurology consultants from Saudi Arabia participated in this study. The years of experience of the participants were 10-20 years (43.1%), most of whom worked in a tertiary healthcare center (72.2%), 31.9% had a certified neurologist trained in IONM, and approximately two-thirds of the institutions did not have an IONM setup (59.7%). Most neurologists believed that IONM should be part of neurology training programs (59.7%). Approximately, half of the respondents believed that IONM was mandatory (52.8%). CONCLUSION: IONM is considered the standard of care in many complex intracranial, spinal, and vascular surgeries. In our study, the perception of neurologists regarding IONM was promising, and the readiness of secondary and tertiary care centers to implement IONM was encouraging. Education, training, implementation, and regulations regarding IONM should be mandatory to prevent operative complications.","Perception; Intraoperative Neurophysiological Monitoring; Saudi Arabia.","adult; article; controlled study; cross-sectional study; female; health care quality; health center; human; interview; intraoperative neurophysiological monitoring; major clinical study; male; middle aged; neurologist; perception; postoperative complication; questionnaire; Saudi Arabia; surgery; tertiary care center; tertiary health care; vascular surgery; young adult","Article","Final","","Scopus","2-s2.0-85177893462"
-"Du M.; Liu M.; Liu J.","Du, Min (57216538976); Liu, Min (57207397673); Liu, Jue (56797105100)","57216538976; 57207397673; 56797105100","Global, regional, and national disease burden and attributable risk factors of HIV/AIDS in older adults aged 70 years and above: A trend analysis based on the Global Burden of Disease study 2019","2024","Epidemiology and Infection","152","","e2","","","","0","10.1017/S0950268823001954","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180358410&doi=10.1017%2fS0950268823001954&partnerID=40&md5=56c7503a3ba2ba0a3250cfd7429b9cd8","We aimed to assess the burden and trend of the HIV/AIDS epidemic among older adults over the past three decades at different geographical levels, based on the data collected from the Global Burden of Diseases (GBD) study 2019. This assessment identified the average annual percentage changes (AAPCs) using Joinpoint regression analysis. Globally, the incidence of HIV/AIDS has decreased (AAPC = -3.107); however, the overall prevalence has consistently increased (AAPC = 5.557). Additionally, both mortality (AAPC = 2.166) and disability-adjusted life years (DALYs; AAPC = 2.429) have increased. The highest increasing trends in female HIV/AIDS incidence and prevalence were observed in the Central Asia region. However, for males, these trends were observed in the Oceania region and the high-income Asia Pacific region, respectively. In recent decades, females aged 70-74 years had the highest incidence and prevalence, while males aged 70-74 years had highest mortality and DALYs in low social development index (SDI) regions. Unsafe sex resulted in 15 381.16 deaths, accounting for 90.73% of all HIV/AIDS deaths, and 331 140.56 DALYs, accounting for 91.12% of all HIV/AIDS DALYs. The HIV/AIDS disease burden differs by region, age, and sex among older adults. Sexual health education and targeted screening for older adults are recommended.  © The Author(s), 2023. Published by Cambridge University Press.","HIV/AIDS; incidence; mortality; older adults; prevalence","Acquired Immunodeficiency Syndrome; Aged; Attenuated familial adenomatous polyposis; Cost of Illness; Female; Global Burden of Disease; Global Health; Humans; Male; Quality-Adjusted Life Years; Risk Factors; acquired immune deficiency syndrome; aged; Article; attributable risk; central Asia; disability-adjusted life year; female; geography; global disease burden; high income country; human; incidence; male; mortality; Pacific islands; prevalence; regression analysis; risk factor; sexual education; social evolution; trend study; unsafe sex; cost of illness; global health; quality adjusted life year; risk factor","Article","Final","","Scopus","2-s2.0-85180358410"
-"Zeighami M.; Malakoutikhah A.; Shahrbabaki P.M.; Al-Oliamat K.; Dehghan M.","Zeighami, Maryam (57217118627); Malakoutikhah, Alireza (57216180578); Shahrbabaki, Parvin Mangolian (58884694700); Al-Oliamat, Kamlah (58884694800); Dehghan, Mahlagha (55634056800)","57217118627; 57216180578; 58884694700; 58884694800; 55634056800","Development and validation of the nurses sexual harassment scale in Iran","2024","BMC Nursing","23","1","107","","","","","10.1186/s12912-024-01759-6","https://www.scopus.com/inward/record.uri?eid=2-s2.0-85184911470&doi=10.1186%2fs12912-024-01759-6&partnerID=40&md5=1e6fdf46209b60af3d013b8293164ab6","Introduction: In recent years, the prevalence of sexual harassment has become a global problem, and nursing, like other professions, has not been immune to this issue. By having a valid and reliable instrument, healthcare personnel can be helped in preventing and managing this problem and reduce its negative consequences on mental health and well-being. The aim of this study was developing and psychometrically measuring the Nurses Sexual Harassment Scale. Materials and methods: This study is the second phase of a mixed method study. Initially in the first phase, a qualitative approach with conventional content analysis was used to explain nurses’ experiences of sexual harassment in the workplace. To design the Nurses Sexual Harassment Scale, qualitative data and literature were reviewed. In the quantitative phase (second phase), the target scale was psychometrically evaluated using content validity (14 experts), face validity (12 nurses with being sexually harassed), construct validity (316 nurses working in hospitals affiliated to Kerman University of Medical Sciences), and reliability (internal consistency and repeatability). Results: A 15-item scale with two components: “latent sexual harassment” (9 items) and “manifest sexual harassment” (6 items), which explained 68.4% of the total variance was developed. Also, due to the strong correlation between the Nurses Sexual Harassment Scale and the Impact of Event Scale-Revised (r = 0.67), convergent validity was confirmed. Also, the scale of the present study had good reliability (Cronbach’s alpha coefficient = 0.94, Omega coefficient = 0.94, and ICC = 0.92). Conclusion: Given the importance of sexual harassment among nurses, measuring the dimensions of this problem may allow professionals to plan interventions to prevent it. Overall, the results of the present study showed that the psychometric properties of the "" Nurses Sexual Harassment Scale” with 15 items are acceptable and this scale can be used in the clinical environment. A further study within the nursing community is recommended to confirm the findings. © The Author(s) 2024.","Analysis; Nurses; Psychometrics; Scale; Sexual harassment","","Article","Final","All Open Access; Gold Open Access","Scopus","2-s2.0-85184911470"