import gradio as gr
import pandas as pd
import numpy as np
import pydicom
import os
import nrrd
from skimage import transform
import torch
from segment_anything import sam_model_registry
import matplotlib.pyplot as plt
from PIL import Image
import torch.nn.functional as F
import io
from gradio_image_prompter import ImagePrompter

def load_nrrd(file_path):
    data, header = nrrd.read(file_path)
    
    # If the data is 3D, take the middle slice
    if len(data.shape) == 3:
        middle_slice = data.shape[2] // 2
        img = data[:, :, middle_slice]
    else:
        img = data

    # Normalize the image to 0-255 range
    img = ((img - img.min()) / (img.max() - img.min()) * 255).astype(np.uint8)

    # Convert grayscale to 3-channel RGB by replicating channels
    if len(img.shape) == 2:  # Grayscale image (height, width)
        img = np.stack((img,)*3, axis=-1)  # Replicate grayscale channel to get (height, width, 3)

    H, W = img.shape[:2]
    return img, H, W

@torch.no_grad()
def medsam_inference(medsam_model, img_embed, box_1024, H, W):
    box_torch = torch.as_tensor(box_1024, dtype=torch.float, device=img_embed.device)
    if len(box_torch.shape) == 2:
        box_torch = box_torch[:, None, :] # (B, 1, 4)

    box_torch=box_torch.reshape(1,4) 
    sparse_embeddings, dense_embeddings = medsam_model.prompt_encoder(
        points=None,
        boxes=box_torch,
        masks=None,
    )
    
    low_res_logits, _ = medsam_model.mask_decoder(
        image_embeddings=img_embed, # (B, 256, 64, 64)
        image_pe=medsam_model.prompt_encoder.get_dense_pe(), # (1, 256, 64, 64)
        sparse_prompt_embeddings=sparse_embeddings, # (B, 2, 256)
        dense_prompt_embeddings=dense_embeddings, # (B, 256, 64, 64)
        multimask_output=False,
    )

    low_res_pred = torch.sigmoid(low_res_logits)  # (1, 1, 256, 256)

    low_res_pred = F.interpolate(
        low_res_pred,
        size=(H, W),
        mode="bilinear",
        align_corners=False,
    )  # (1, 1, gt.shape)
    low_res_pred = low_res_pred.squeeze().cpu().numpy()  # (256, 256)
    medsam_seg = (low_res_pred > 0.5).astype(np.uint8)
    return medsam_seg

def visualize(image, mask, box):
    fig, ax = plt.subplots(1, 2, figsize=(10, 5))
    ax[0].imshow(image, cmap='gray')
    ax[0].add_patch(plt.Rectangle((box[0], box[1]), box[2] - box[0], box[3] - box[1], edgecolor="red", facecolor="none"))
    ax[1].imshow(image, cmap='gray')
    ax[1].imshow(mask, alpha=0.5, cmap="jet")
    plt.tight_layout()

    buf = io.BytesIO()
    fig.savefig(buf, format='png')
    plt.close(fig)
    buf.seek(0)
    pil_img = Image.open(buf)
    
    return pil_img 

def process_nrrd(nrrd_file, points):
    device = 'cuda' if torch.cuda.is_available() else 'cpu'
    
    # Load and preprocess NRRD file
    image, H, W = load_nrrd(nrrd_file.name)
    
    if len(points) >= 6:
        x_min, y_min, x_max, y_max = points[0], points[1], points[3], points[4]
    else:
        raise ValueError("Insufficient data for bounding box coordinates.")

    image_resized = transform.resize(image, (1024, 1024), order=3, preserve_range=True, anti_aliasing=True).astype(np.uint8)
    image_resized = (image_resized - image_resized.min()) / np.clip(image_resized.max() - image_resized.min(), a_min=1e-8, a_max=None)
    image_tensor = torch.tensor(image_resized).float().permute(2, 0, 1).unsqueeze(0).to(device)

    # Initialize the MedSAM model and set the device
    model_checkpoint_path = "medsam_vit_b.pth"  # Replace with the correct path to your checkpoint
    medsam_model = sam_model_registry['vit_b'](checkpoint=model_checkpoint_path)
    medsam_model = medsam_model.to(device)
    medsam_model.eval()

    # Generate image embedding
    with torch.no_grad():
        img_embed = medsam_model.image_encoder(image_tensor)

    # Calculate resized box coordinates
    scale_factors = np.array([1024 / W, 1024 / H, 1024 / W, 1024 / H])
    box_1024 = np.array([x_min, y_min, x_max, y_max]) * scale_factors

    # Perform inference
    mask = medsam_inference(medsam_model, img_embed, box_1024, H, W)

    # Visualization
    visualization = visualize(image, mask, [x_min, y_min, x_max, y_max])
    return visualization

# Set up Gradio interface
iface = gr.Interface(
    fn=process_nrrd,
    inputs=[
        gr.File(label="NRRD File"),
        gr.JSON(label="Bounding Box Coordinates")
    ],
    outputs=[
        gr.Image(type="pil", label="Processed Image")
    ],
    title="ROI Selection with MEDSAM for NRRD Files",
    description="Upload an NRRD file and provide bounding box coordinates for processing."
)

# Launch the interface
iface.launch()