|
# cython: language_level=3 |
|
############################################################################### |
|
############################################################################### |
|
## Cython wrapper for htslib VCF/BCF reader/writer |
|
############################################################################### |
|
# |
|
# The MIT License |
|
# |
|
# Copyright (c) 2015, 2016 Kevin Jacobs (jacobs@bioinformed.com) |
|
# |
|
# Permission is hereby granted, free of charge, to any person obtaining a |
|
# copy of this software and associated documentation files (the "Software"), |
|
# to deal in the Software without restriction, including without limitation |
|
# the rights to use, copy, modify, merge, publish, distribute, sublicense, |
|
# and/or sell copies of the Software, and to permit persons to whom the |
|
# Software is furnished to do so, subject to the following conditions: |
|
# |
|
# The above copyright notice and this permission notice shall be included in |
|
# all copies or substantial portions of the Software. |
|
# |
|
# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR |
|
# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, |
|
# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL |
|
# THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER |
|
# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING |
|
# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER |
|
# DEALINGS IN THE SOFTWARE. |
|
# |
|
############################################################################### |
|
|
|
from libc.stdint cimport int8_t, int16_t, int32_t, int64_t |
|
from libc.stdint cimport uint8_t, uint16_t, uint32_t, uint64_t |
|
from libc.stdlib cimport malloc, calloc, realloc, free |
|
from libc.string cimport memcpy, memcmp, memmove, strncpy, strlen, strdup |
|
|
|
from pysam.libchtslib cimport * |
|
|
|
|
|
cdef class VariantHeader(object): |
|
cdef bcf_hdr_t *ptr |
|
|
|
cdef _add_sample(self, name) |
|
cdef _hdr_sync(self) |
|
cdef _subset_samples(self, include_samples) |
|
|
|
|
|
cdef class VariantHeaderRecord(object): |
|
cdef readonly VariantHeader header |
|
cdef bcf_hrec_t *ptr |
|
|
|
|
|
cdef class VariantHeaderRecords(object): |
|
cdef readonly VariantHeader header |
|
|
|
|
|
cdef class VariantHeaderContigs(object): |
|
cdef readonly VariantHeader header |
|
|
|
|
|
cdef class VariantHeaderSamples(object): |
|
cdef readonly VariantHeader header |
|
|
|
|
|
cdef class VariantContig(object): |
|
cdef readonly VariantHeader header |
|
cdef int id |
|
|
|
|
|
cdef class VariantMetadata(object): |
|
cdef readonly VariantHeader header |
|
cdef int type |
|
cdef int id |
|
|
|
|
|
cdef class VariantHeaderMetadata(object): |
|
cdef readonly VariantHeader header |
|
cdef int32_t type |
|
|
|
|
|
cdef class VariantRecord(object): |
|
cdef readonly VariantHeader header |
|
cdef bcf1_t *ptr |
|
|
|
|
|
cdef class VariantRecordFilter(object): |
|
cdef VariantRecord record |
|
|
|
|
|
cdef class VariantRecordFormat(object): |
|
cdef VariantRecord record |
|
|
|
|
|
cdef class VariantRecordInfo(object): |
|
cdef VariantRecord record |
|
|
|
|
|
cdef class VariantRecordSamples(object): |
|
cdef VariantRecord record |
|
|
|
|
|
cdef class VariantRecordSample(object): |
|
cdef VariantRecord record |
|
cdef readonly int32_t index |
|
|
|
|
|
cdef class BaseIndex(object): |
|
cdef tuple refs |
|
cdef dict refmap |
|
|
|
|
|
cdef class BCFIndex(BaseIndex): |
|
cdef readonly VariantHeader header |
|
cdef hts_idx_t *ptr |
|
|
|
|
|
cdef class TabixIndex(BaseIndex): |
|
cdef tbx_t *ptr |
|
|
|
|
|
cdef class BaseIterator(object): |
|
cdef VariantFile bcf |
|
cdef hts_itr_t *iter |
|
|
|
|
|
cdef class BCFIterator(BaseIterator): |
|
cdef BCFIndex index |
|
|
|
|
|
cdef class TabixIterator(BaseIterator): |
|
cdef TabixIndex index |
|
cdef kstring_t line_buffer |
|
|
|
|
|
cdef class VariantFile(HTSFile): |
|
cdef readonly VariantHeader header |
|
cdef readonly BaseIndex index |
|
|
|
cdef readonly bint drop_samples # true if sample information is to be ignored |
|
|
|
# FIXME: Temporary, use htsFormat when it is available |
|
cdef readonly bint is_reading # true if file has begun reading records |
|
cdef readonly bint header_written # true if header has already been written |
|
|
|
cpdef int write(self, VariantRecord record) except -1 |
|
|