import collections
from typing import Dict, List

import gradio as gr

from get_index import get_engines
from protein_viz import get_pdb_title, render_html

index_repo = "ronig/protein_index"
model_repo = "ronig/protein_search_engine"
engines = get_engines(index_repo, model_repo)
available_indexes = list(engines.keys())
app_description = """
# Protein Binding Search Engine
This application enables a quick protein-peptide binding search based on sequences. 
You can use it to search the full [PDB](https://www.rcsb.org/) database or in a specific organism genome.
"""
max_results = 1000
choice_sep = " | "
max_seq_length = 50


def search_and_display(seq, max_res, index_selection):
    n_search_res = 10000
    _validate_sequence_length(seq)
    max_res = int(limit_n_results(max_res))
    engine = engines[index_selection]
    search_res = engine.search_by_sequence(seq, n=n_search_res)
    agg_search_results = aggregate_search_results(search_res, max_res)
    formatted_search_results = format_search_results(agg_search_results)
    results_options = update_dropdown_menu(agg_search_results)
    return formatted_search_results, results_options


def _validate_sequence_length(seq):
    if len(seq) > max_seq_length:
        raise gr.Error("Only peptide input is currently supported")


def limit_n_results(n):
    return max(min(n, max_results), 1)


def aggregate_search_results(raw_results: List[dict], max_res: int) -> Dict[str, dict]:
    aggregated_by_uniprot = collections.defaultdict(list)
    for raw_result in raw_results:
        entry = select_keys(
            raw_result,
            keys=["pdb_name", "chain_id", "score", "organism", "uniprot_id", "genes"],
        )
        uniprot_id = raw_result["uniprot_id"]

        if uniprot_id is not None:
            aggregated_by_uniprot[uniprot_id].append(entry)
            if len(aggregated_by_uniprot) >= max_res:
                return dict(aggregated_by_uniprot)
    return dict(aggregated_by_uniprot)


def select_keys(d: dict, keys: List[str]):
    return {key: d[key] for key in keys}


def format_search_results(agg_search_results):
    formatted_search_results = {}
    for uniprot_id, entries in agg_search_results.items():
        entry = entries[0]
        organism = entry["organism"]
        score = entry["score"]
        genes = entry["genes"]
        key = f"Uniprot ID: {uniprot_id} | Organism: {organism} | Gene Names: {genes}"
        formatted_search_results[key] = score
    return formatted_search_results


def update_dropdown_menu(agg_search_res):
    choices = []
    for uniprot_id, entries in agg_search_res.items():
        for entry in entries:
            choice = choice_sep.join(
                [
                    uniprot_id,
                    entry["pdb_name"],
                    entry["chain_id"],
                    entry["genes"] or "",
                ]
            )
            choices.append(choice)

    if choices:
        update = gr.Dropdown.update(
            choices=choices, interactive=True, value=choices[0], visible=True
        )
    else:
        update = gr.Dropdown.update(
            choices=choices, interactive=True, visible=False, value=None
        )
    return update


def parse_pdb_search_result(raw_result):
    prot = raw_result["pdb_name"]
    chain = raw_result["chain_id"]
    value = raw_result["score"]
    gene_names = raw_result["genes"]
    species = raw_result["organism"]
    key = f"PDB: {prot}.{chain}"
    if gene_names is not None:
        key += f" | Genes: {gene_names} | Organism: {species}"
    return key, value


def switch_viz(new_choice):
    if new_choice is None:
        html = ""
        title_update = gr.Markdown.update(visible=False)
        description_update = gr.Markdown.update(value=None, visible=False)
    else:
        choice_parts = new_choice.split(choice_sep)
        pdb_id, chain = choice_parts[1:3]
        title_update = gr.Markdown.update(visible=True)
        pdb_title = get_pdb_title(pdb_id)

        new_value = f"""**PDB Title**: {pdb_title}"""

        description_update = gr.Markdown.update(value=new_value, visible=True)
        html = render_html(pdb_id=pdb_id, chain=chain)
    return html, title_update, description_update


with gr.Blocks() as demo:
    with gr.Column():
        with gr.Column():
            with gr.Row():
                with gr.Column():
                    seq_input = gr.Textbox(value="APTMPPPLPP", label="Input Sequence")
                    n_results = gr.Number(10, label="N Results")
                    index_selector = gr.Dropdown(
                        choices=available_indexes,
                        value="All Species",
                        multiselect=False,
                        visible=True,
                        label="Index",
                    )
                    search_button = gr.Button("Search", variant="primary")
                search_results = gr.Label(
                    num_top_classes=max_results, label="Search Results"
                )
            viz_header = gr.Markdown("## Visualization", visible=False)
            results_selector = gr.Dropdown(
                choices=[],
                multiselect=False,
                visible=False,
                label="Visualized Search Result",
            )
            viz_body = gr.Markdown("", visible=False)
            protein_viz = gr.HTML(
                value=render_html(pdb_id=None, chain=None),
                label="Protein Visualization",
            )
            gr.Examples(
                ["APTMPPPLPP", "KFLIYQMECSTMIFGL", "PHFAMPPIHEDHLE", "AEERIISLD"],
                inputs=[seq_input],
            )
    search_button.click(
        search_and_display,
        inputs=[seq_input, n_results, index_selector],
        outputs=[search_results, results_selector],
    )
    results_selector.change(
        switch_viz, inputs=results_selector, outputs=[protein_viz, viz_header, viz_body]
    )

if __name__ == "__main__":
    demo.launch()