metadata
base_model: microsoft/mdeberta-v3-base
library_name: sentence-transformers
metrics:
- cosine_accuracy@1
- cosine_accuracy@3
- cosine_accuracy@5
- cosine_accuracy@10
- cosine_precision@1
- cosine_precision@3
- cosine_precision@5
- cosine_precision@10
- cosine_recall@1
- cosine_recall@3
- cosine_recall@5
- cosine_recall@10
- cosine_ndcg@10
- cosine_mrr@10
- cosine_map@100
- dot_accuracy@1
- dot_accuracy@3
- dot_accuracy@5
- dot_accuracy@10
- dot_precision@1
- dot_precision@3
- dot_precision@5
- dot_precision@10
- dot_recall@1
- dot_recall@3
- dot_recall@5
- dot_recall@10
- dot_ndcg@10
- dot_mrr@10
- dot_map@100
pipeline_tag: sentence-similarity
tags:
- sentence-transformers
- sentence-similarity
- feature-extraction
- generated_from_trainer
- dataset_size:110575
- loss:MultipleNegativesRankingLoss
widget:
- source_sentence: plant-based diets
sentences:
- >-
Effect of a low-fat high-carbohydrate diet on symptoms of cyclical
mastopathy. 21 patients with severe persistent cyclical mastopathy of at
least 5 years' duration were randomised to a control group who received
general dietary advice or to an intervention group who were taught how
to reduce the fat content of their diet to 15% of calories while
increasing complex carbohydrate consumption to maintain caloric intake.
Both groups were followed for 6 months with food records and measurement
of plasma hormone and lipid levels. Severity of symptoms was recorded
with daily diaries and patients were assessed at the beginning and end
of the study by a physician who was unaware of their dietary regimen.
After 6 months there was a significant reduction in the intervention
group in the severity of premenstrual breast tenderness and swelling.
Physical examination showed reduced breast swelling, tenderness, and
nodularity in 6 of 10 patients in the intervention group and 2 of 9
patients in the control group.
- >-
Cranberries and cranberry products: powerful in vitro, ex vivo, and in
vivo sources of antioxidants. Cranberry products and especially
cranberry juice (CJ) have been consumed for health reasons primarily due
to their effect on urinary tract infections. We investigated the
quantity of both free and total (after hydrolysis) phenolic antioxidants
in cranberry products using the Folin assay. The order of amount of
total polyphenols in cranberry foods on a fresh weight basis was as
follows: dried > frozen > sauce > jellied sauce. On a serving size basis
for all cranberry products, the order was as follows: frozen > 100%
juice > dried > 27% juice > sauce > jellied sauce. High fructose corn
syrup (HFCS) is a major source of sugar consumption in the U.S. and
contains both glucose and fructose, potential mediators of oxidative
stress. We investigated the effect of the consumption of HFCS and
ascorbate with CJ antioxidants or without CJ (control) given to 10
normal individuals after an overnight fast. Plasma antioxidant capacity,
glucose, triglycerides, and ascorbate were measured 6 times over 7 h
after the consumption of a single 240 mL serving of the two different
beverages. The control HFCS caused a slight decrease in plasma
antioxidant capacity at all time points and thus an oxidative stress in
spite of the presence of ascorbate. CJ produced an increase in plasma
antioxidant capacity that was significantly greater than control HFCS at
all time points. Postprandial triglycerides, due to fructose in the
beverages, were mainly responsible for the oxidative stress and were
significantly correlated with the oxidative stress as measured by the
antioxidant capacity. Cranberries are an excellent source of high
quality antioxidants and should be examined in human supplementation
studies.
- >-
Açai Palm Fruit (Euterpe oleracea Mart.) Pulp Improves Survival of Flies
on a High Fat Diet Reducing oxidative damage is thought to be an
effective aging intervention. Açai, a fruit indigenous to the Amazon, is
rich in phytochemicals that possesses high anti-oxidant activities, and
has anti-inflammatory, anti-cancer and anti-cardiovascular disease
properties. However, little is known about its potential anti-aging
properties especially at the organismal level. Here we evaluated the
effect of açai pulp on modulating lifespan in Drosophila melanogaster.
We found that açai supplementation at 2% in the food increased the
lifespan of female flies fed a high fat diet compared to the
non-supplemented control. We measured transcript changes induced by açai
for age-related genes. Although transcript levels of most genes tested
were not altered, açai increased the transcript level of l(2)efl, a
small heat-shock-related protein, and two detoxification genes, gstD1
and mtnA, while decreasing the transcript level of phosphoenolpyruvate
carboxykinase (Pepck), a key gene involved in gluconeogenesis.
Furthermore, açai increased the lifespan of oxidative stressed females
caused by sod1 RNAi. This suggests that açai improves survival of flies
fed a high fat diet through activation of stress response pathways and
suppression of Pepck expression. Açai has the potential to antagonize
the detrimental effect of fat in the diet and alleviate oxidative stress
in aging.
- source_sentence: reproductive health
sentences:
- >-
Do national advisories serve local consumers: an assessment of mercury
in economically important North Carolina fish. Consumption of marine
fish provides both benefits (lean protein, omega-3 fatty acids and
essential nutrients) and risks (main source of mercury (Hg) exposure for
humans). Mercury is a potent neurotoxin and the source of more fish
advisories nationwide than any other toxicant. Despite the widespread
nature of Hg, it is unknown whether local Hg contamination reflects
national and regional levels often used as bases to inform consumers of
potential fish consumption risk. Thus, the objectives of our study were
to examine Hg levels of six commonly consumed marine species harvested
locally off the North Carolina coast and to compare our results to
published regional (Monterey Bay Aquarium's Seafood Watch List) and
national (Environmental Protection Agency, EPA, and Food and Drug
Administration, FDA) Hg averages, action levels, and guidelines. We
found significant differences in Hg concentrations among collected
species, and we identified correlations between Hg concentration and
fish length and trophic levels. Collected mahi mahi and triggerfish were
below the EPA fish tissue action level (0.3ppm). Wahoo and grouper
exceeded the EPA action level but were below the FDA action level
(1.0ppm). King mackerel had the highest Hg concentration among targeted
species, exceeding both EPA and FDA action levels. Further, our local
results were not always consistent with calculated averages from EPA and
FDA databases for the same species, and although many of our findings
were consistent with Monterey Bay Aquarium's Seafood Watch List
(southeast region), recommendations based on Hg levels would conflict
with recommendations they provide based on sustainability. We find
regional and national averages are not always reflective of local Hg
contamination and suggest local data may be needed to accurately assess
consumer risk.
- >-
Purple rice (Oryza sativa L.) extract and its constituents inhibit
VEGF-induced angiogenesis. The study evaluated the protective effects of
purple rice (Oryza sativa L.) bran extract (PRE) and its constituents,
cyanidin and peonidin, against angiogenesis induced by vascular
endothelial growth factor (VEGF). The effects of VEGF and PRE were
examined by in vitro tube formation assays and following 14-day
co-culture of human umbilical vein endothelial cells (HUVECs) and
fibroblasts. The antiangiogenic mechanism of PRE was evaluated by
VEGF-induced proliferation and migration of HUVECs and/or human retinal
microvascular endothelial cells (HRMECs) and phosphorylation of
extracellular signal-regulated kinase (ERK) and p38. The PRE
significantly suppressed VEGF-induced tube formation, proliferation and
migration in HUVECs and HRMECs as well as phosphorylation of ERK and
p38. Cyanidin and peonidin also suppressed the proliferation and
migration induced by VEGF. These findings indicate that PRE and
anthocyanidins suppress VEGF-induced angiogenesis by inhibiting
proliferation and migration and suggest that the inhibition of
phosphorylated-ERK and -p38 may be involved in the underlying mechanism.
Copyright © 2011 John Wiley & Sons, Ltd.
- >-
Endurance exercise results in DNA damage as detected by the comet assay.
To determine if 6 weeks of supplementation with antioxidants could
alleviate exercise-induced DNA damage, we studied 21 runners during a 50
km ultramarathon. Subjects were randomly assigned to one of two groups:
(1) placebos (PL) or (2) antioxidants (AO) (1000 mg vitamin C and 400 IU
RRR-alpha-tocopheryl acetate). The comet assay was used to assess DNA
damage in circulating leukocytes at selected time points: pre-, mid-,
and 2 h postrace and daily for 6 days postrace. All subjects completed
the race: run time 7.1 +/- 0.1 h, energy expenditure 5008 +/- 80 kcal
for women (n = 10) and 6932 +/- 206 kcal for men (n = 11). Overall, the
percentage DNA damage increased at midrace (p <.02), but returned to
baseline by 2 h postrace, indicating that the exercise bout induced
nonpersistent DNA damage. There was a gender x treatment x time
interaction (p <.01). One day postrace, women taking AO had 62% less DNA
damage than women taking PL (p <.0008). In contrast, there were no
statistically significant differences between the two treatment groups
of men at any time point. Thus, endurance exercise resulted in DNA
damage as shown by the comet assay and AO seemed to enhance recovery in
women but not in men.
- source_sentence: immune function
sentences:
- >-
Relationship between the prenatal exposure to low-level of mercury and
the size of a newborn's cerebellum. Exposure to methylmercury at any
stage of central nervous system development could induce alterations and
result in severe congenital abnormalities. Total mercury level in
maternal hair during pregnancy correlates well with blood levels of
methylmercury and with total mercury levels in fetal brain. A
prospective study has been conducted and a total of 137 childbearing
women living at the coastal region with term, normal pregnancies were
included and their newborns evaluated by ultrasonography. Mothers and
their newborns are divided in two groups according to their hair mercury
levels; examined group with high body levels of mercury (≥ 1 μg/g) and
control group with low body levels of mercury (<1 μg/g).
Neurosonographic examination was conducted to all newborns. Two
dimensions of cerebellum in the sagital-medial plane have been measured:
maximum height and width starting from the roof of the fourth chamber.
Majority of mothers had hair mercury levels lower than 1 μg/g (N = 107).
Mean value was 0.88 μg/g (SD 1.24), ranging from 0.02 to 8.71 μg/g.
There was no significant difference between the two groups when it comes
to the width of cerebellum (Mann-Whitney test: Z = 1471; p = 0.141).
However, comparison related to the length of cerebellum shows
statistically significant smaller cerebellum in newborns whose mother
had hair mercury levels higher than 1 μg/g (Mann-Whitney test: Z = 2329;
p = 0.019). Our results lead to a conclusion that prenatal exposure to,
what we consider to be, low-levels of methylmercury does influence fetal
brain development detected as decreased size of newborn's cerebellum.
From a clinical point of view, a question related to the influence of
prenatal low-level methylmercury exposure on fetal neurodevelopment
remains open. Our further objectives are to direct the research towards
performing detailed neuropshychological tests on children at the age of
18 months. Such tests could indicate the presence of subtle neurological
or neuropsychological deficits. Copyright © 2010 Elsevier Ltd. All
rights reserved.
- >-
Radioprotective effects of Zingiber officinale Roscoe (ginger): past,
present and future. Radiation is an important modality in treating
people with cancer especially when surgical intervention is
impracticable or might debilitate the patient. However, effective use of
ionizing radiation is compromised by the side effects that result from
radiation-induced damage to normal tissue. The use of radioprotective
compounds, which can selectively protect normal tissues against
radiation injury is of immense use because in addition to association
with protecting the normal tissue, it will also permits use of higher
doses of radiation to obtain better cancer control and possible cure.
However, till date no ideal radioprotectors are available as most
synthetic compounds are toxic at their optimal concentrations. Plants
commonly used as dietary and or therapeutic agents have recently been
the focus of attention since in most cases they are non-toxic and are
easily accepted for human use. Ginger, the rhizomes of Zingiber
officinale Roscoe (Zingiberaceae), has widely been used as both culinary
and medicinal agent. Preclinical studies carried out in the last decade
has shown that ginger and its phytochemicals dehydrozingerone, zingerone
possess radioprotective effects in laboratory animals and in cultured
cells in vitro. The hydroalcoholic extract of ginger rhizome when
administered either through intraperitoneal or oral route was effective
in protecting against gamma radiation-induced sickness and mortality.
The phytochemicals dehydrogingerone and zingerone present in ginger are
also shown to protect mice against radiation-induced sickness and
mortality. Mechanistic studies have indicated that the free radical
scavenging, antioxidant affects, anti-inflammatory and anti-clastogenic
effects may contribute towards the observed protection. Additionally,
studies with tumor bearing mice have also shown that zingerone
selectively protects the normal tissues against the tumoricidal effects
of radiation. This review for the first time summarizes the results
related to the radioprotective properties and also emphasizes the
aspects that warrant future research to establish its activity and
utility as a radioprotective agent.
- >-
Traditional non-Western diets. In traditional cultures, balancing health
with a balanced lifestyle was a core belief. The diseases of modern
civilization were rare. Indigenous people have patterns of illness very
different from Western civilization; yet, they rapidly develop diseases
once exposed to Western foods and lifestyles. Food and medicine were
interwoven. All cultures used special or functional foods to prevent
disease. Food could be used at different times either as food or
medicine. Foods, cultivation, and cooking methods maximized community
health and well-being. With methods passed down through generations,
cooking processes were utilized that enhanced mineral and nutrient
bioavailability. This article focuses on what researchers observed about
the food traditions of indigenous people, their disease patterns, the
use of specific foods, and the environmental factors that affect people
who still eat traditional foods.
- source_sentence: ginger
sentences:
- >-
Xeno-estrogenic compounds in precipitation. The exposure to some
chemicals can lead to hormone disrupting effects. Presently, much
attention is focused on so-called xeno-estrogens, synthetic compounds
that interact with hormone receptors causing a number of reactions that
eventually lead to effects related to reproduction and development. The
current study was initiated to investigate the presence of a number of
such compounds in precipitation as a follow-up on a previous study in
which pesticide concentrations in air and precipitation were determined.
Rainwater samples were collected at about 50 locations in The
Netherlands in a four week period. The samples were analysed for
bisphenol-A, alkylphenols and alkylphenol ethoxylates, phthalates, flame
retardants and synthetic musk compounds. The results clearly indicated
the presence of these compounds in precipitation. The concentrations
ranged from the low ng l(-1) range for flame retardants to several
thousands of ng l(-1) for the phthalates. Bisphenol-A was found in 30%
of the samples in concentrations up to 130 ng l(-1), while alkylphenols
and alkylphenol ethoxylates were found in virtually all locations in
concentrations up to 920 ng l(-1) for the individual compounds.
Phthalates were by far the most abundant xeno-estrogens in the
precipitation samples and were found in every sample. Di-isodecyl
phthalate was found in a surprisingly high concentration of almost 100
000 ng l(-1). Polybrominated flame retardants were found in the low ng
l(-1) range and generally in less than 20% of the samples. Noticeable
was the finding of hexabromocyclododecane, a replacement for the
polybrominted diphenyl ethers at one location in a concentration of
almost 2000 ng l(-1). Finally, as expected, synthetic musk compounds
were detected in almost all samples. This is especially true for the
polycyclic musks HHCB and AHTN. Nitro musks were found, but only on a
few locations. Kriging techniques were used to calculate precipitation
concentrations in between actual sampling locations to produce contour
plots for a number of compounds. These plots clearly show located
emission sources for a number of compounds such as bisphenol-A,
nonylphenol ethoxylate, phthalates and AHTN. On the contrary, the
results for HHCB and some phthalates indicated diffuse emission
patterns, probably as the result of the use of consumer products
containing these compounds.
- >-
The state of US health, 1990-2010: burden of diseases, injuries, and
risk factors. IMPORTANCE: Understanding the major health problems in the
United States and how they are changing over time is critical for
informing national health policy. OBJECTIVES: To measure the burden of
diseases, injuries, and leading risk factors in the United States from
1990 to 2010 and to compare these measurements with those of the 34
countries in the Organisation for Economic Co-operation and Development
(OECD) countries. DESIGN: We used the systematic analysis of descriptive
epidemiology of 291 diseases and injuries, 1160 sequelae of these
diseases and injuries, and 67 risk factors or clusters of risk factors
from 1990 to 2010 for 187 countries developed for the Global Burden of
Disease 2010 Study to describe the health status of the United States
and to compare US health outcomes with those of 34 OECD countries. Years
of life lost due to premature mortality (YLLs) were computed by
multiplying the number of deaths at each age by a reference life
expectancy at that age. Years lived with disability (YLDs) were
calculated by multiplying prevalence (based on systematic reviews) by
the disability weight (based on population-based surveys) for each
sequela; disability in this study refers to any short- or long-term loss
of health. Disability-adjusted life-years (DALYs) were estimated as the
sum of YLDs and YLLs. Deaths and DALYs related to risk factors were
based on systematic reviews and meta-analyses of exposure data and
relative risks for risk-outcome pairs. Healthy life expectancy (HALE)
was used to summarize overall population health, accounting for both
length of life and levels of ill health experienced at different ages.
RESULTS: US life expectancy for both sexes combined increased from 75.2
years in 1990 to 78.2 years in 2010; during the same period, HALE
increased from 65.8 years to 68.1 years. The diseases and injuries with
the largest number of YLLs in 2010 were ischemic heart disease, lung
cancer, stroke, chronic obstructive pulmonary disease, and road injury.
Age-standardized YLL rates increased for Alzheimer disease, drug use
disorders, chronic kidney disease, kidney cancer, and falls. The
diseases with the largest number of YLDs in 2010 were low back pain,
major depressive disorder, other musculoskeletal disorders, neck pain,
and anxiety disorders. As the US population has aged, YLDs have
comprised a larger share of DALYs than have YLLs. The leading risk
factors related to DALYs were dietary risks, tobacco smoking, high body
mass index, high blood pressure, high fasting plasma glucose, physical
inactivity, and alcohol use. Among 34 OECD countries between 1990 and
2010, the US rank for the age-standardized death rate changed from 18th
to 27th, for the age-standardized YLL rate from 23rd to 28th, for the
age-standardized YLD rate from 5th to 6th, for life expectancy at birth
from 20th to 27th, and for HALE from 14th to 26th. CONCLUSIONS AND
RELEVANCE: From 1990 to 2010, the United States made substantial
progress in improving health. Life expectancy at birth and HALE
increased, all-cause death rates at all ages decreased, and age-specific
rates of years lived with disability remained stable. However, morbidity
and chronic disability now account for nearly half of the US health
burden, and improvements in population health in the United States have
not kept pace with advances in population health in other wealthy
nations.
- >-
Curcumin as "Curecumin": from kitchen to clinic. Although turmeric
(Curcuma longa; an Indian spice) has been described in Ayurveda, as a
treatment for inflammatory diseases and is referred by different names
in different cultures, the active principle called curcumin or
diferuloylmethane, a yellow pigment present in turmeric (curry powder)
has been shown to exhibit numerous activities. Extensive research over
the last half century has revealed several important functions of
curcumin. It binds to a variety of proteins and inhibits the activity of
various kinases. By modulating the activation of various transcription
factors, curcumin regulates the expression of inflammatory enzymes,
cytokines, adhesion molecules, and cell survival proteins. Curcumin also
downregulates cyclin D1, cyclin E and MDM2; and upregulates p21, p27,
and p53. Various preclinical cell culture and animal studies suggest
that curcumin has potential as an antiproliferative, anti-invasive, and
antiangiogenic agent; as a mediator of chemoresistance and
radioresistance; as a chemopreventive agent; and as a therapeutic agent
in wound healing, diabetes, Alzheimer disease, Parkinson disease,
cardiovascular disease, pulmonary disease, and arthritis. Pilot phase I
clinical trials have shown curcumin to be safe even when consumed at a
daily dose of 12g for 3 months. Other clinical trials suggest a
potential therapeutic role for curcumin in diseases such as familial
adenomatous polyposis, inflammatory bowel disease, ulcerative colitis,
colon cancer, pancreatic cancer, hypercholesteremia, atherosclerosis,
pancreatitis, psoriasis, chronic anterior uveitis and arthritis. Thus,
curcumin, a spice once relegated to the kitchen shelf, has moved into
the clinic and may prove to be "Curecumin".
- source_sentence: hot dogs
sentences:
- >-
Occurrence of pharmaceuticals and personal care products in fish:
results of a national pilot study in the United States. Pharmaceuticals
and personal care products are being increasingly reported in a variety
of biological matrices, including fish tissue; however, screening
studies have presently not encompassed broad geographical areas. A
national pilot study was initiated in the United States to assess the
accumulation of pharmaceuticals and personal care products in fish
sampled from five effluent-dominated rivers that receive direct
discharge from wastewater treatment facilities in Chicago, Illinois;
Dallas, Texas; Orlando, Florida; Phoenix, Arizona; and West Chester,
Pennsylvania, USA. Fish were also collected from the Gila River, New
Mexico, USA, as a reference condition expected to be minimally impacted
by anthropogenic influence. High performance liquid
chromatography-tandem mass spectrometry analysis of pharmaceuticals
revealed the presence of norfluoxetine, sertraline, diphenhydramine,
diltiazem, and carbamazepine at nanogram-per-gram concentrations in
fillet composites from effluent-dominated sampling locations; the
additional presence of fluoxetine and gemfibrozil was confirmed in liver
tissue. Sertraline was detected at concentrations as high as 19 and 545
ng/g in fillet and liver tissue, respectively. Gas chromatography-tandem
mass spectrometry analysis of personal care products in fillet
composites revealed the presence of galaxolide and tonalide at maximum
concentrations of 2,100 and 290 ng/g, respectively, and trace levels of
triclosan. In general, more pharmaceuticals were detected at higher
concentrations and with greater frequency in liver than in fillet
tissues. Higher lipid content in liver tissue could not account for this
discrepancy as no significant positive correlations were found between
accumulated pharmaceutical concentrations and lipid content for either
tissue type from any sampling site. In contrast, accumulation of the
personal care products galaxolide and tonalide was significantly related
to lipid content. Results suggest that the detection of pharmaceuticals
and personal care products was dependent on the degree of wastewater
treatment employed.
- >-
Dietary modification of human macular pigment density. PURPOSE: The
retinal carotenoids lutein (L) and zeaxanthin (Z) that form the macular
pigment (MP) may help to prevent neovascular age-related macular
degeneration. The purpose of this study was to determine whether MP
density in the retina could be raised by increasing dietary intake of L
and Z from foods. METHODS: Macular pigment was measured psychophysically
for 13 subjects. Serum concentrations of L, Z, and beta-carotene were
measured by high-performance liquid chromatography. Eleven subjects
modified their usual daily diets by adding 60 g of spinach (10.8 mg L,
0.3 mg Z, 5 mg beta-carotene) and ten also added 150 g of corn (0.3 mg
Z, 0.4 mg L); two other subjects were given only corn. Dietary
modification lasted up to 15 weeks. RESULTS: For the subjects fed
spinach or spinach and corn, three types of responses to dietary
modification were identified: Eight "retinal responders" had increases
in serum L (mean, 33%; SD, 22%) and in MP density (mean, 19%; SD, 11%);
two "retinal nonresponders" showed substantial increases in serum L
(mean, 31%) but not in MP density (mean, -11%); one "serum and retinal
nonresponder" showed no changes in serum L, Z, or beta-carotene and no
change in MP density. For the two subjects given only corn, serum L
changed little (+11%, -6%), but in one subject serum Z increased (70%)
and MP density increased (25%). CONCLUSIONS: Increases in MP density
were obtained within 4 weeks of dietary modification for most, but not
all, subjects. When MP density increased with dietary modification, it
remained elevated for at least several months after resuming an
unmodified diet. Augmentation of MP for both experimental and clinical
investigation appears to be feasible for many persons.
- >-
Habitual physical exercise has beneficial effects on telomere length in
postmenopausal women. OBJECTIVE: It has been reported that women benefit
from the maintenance of telomere length by estrogen. Exercise may
favorably influence telomere length, although results are inconsistent
regarding the duration and type of exercise and the cell type used to
measure telomere length. The purpose of this study was to investigate
the relationship between habitual physical exercise and telomere length
in peripheral blood mononuclear cells (PBMCs) in postmenopausal women.
Postmenopausal women were chosen as study participants because they are
typically estrogen deficient. METHODS: This experimental-control,
cross-sectional study included 44 healthy, nondiabetic, nonsmoking,
postmenopausal women. Habitual exercisers and sedentary participants
were matched for age and body mass index. Body weight, height, blood
pressure, and waist and hip circumference were measured. Mitochondrial
DNA copy number and telomere length in PBMCs were determined, and
biochemical tests were performed. Habitual physical exercise was defined
as combined aerobic and resistance exercise performed for at least 60
minutes per session more than three times a week for more than 12
months. RESULTS: The mean age of all participants was 58.11 ± 6.84
years, and participants in the habitual exercise group had been
exercising more than three times per week for an average of 19.23 ± 5.15
months. Serum triglyceride levels (P = 0.01), fasting insulin
concentrations (P < 0.01), and homeostasis model assessment of insulin
resistance (P < 0.01) were significantly lower and high-density
lipoprotein cholesterol levels (P < 0.01), circulating adiponectin (P <
0.01), mitochondrial DNA copy number (P < 0.01), and telomere length (P
< 0.01) were significantly higher in the habitual exercise group than in
the sedentary group. In a stepwise multiple regression analysis,
habitual exercise (β = 0.522, P < 0.01) and adiponectin levels (β =
0.139, P = 0.03) were the independent factors associated with the
telomere length of PBMCs in postmenopausal women. CONCLUSIONS: Habitual
physical exercise is associated with greater telomere length in
postmenopausal women. This finding suggests that habitual physical
exercise in postmenopausal women may reduce telomere attrition.
model-index:
- name: SentenceTransformer based on microsoft/mdeberta-v3-base
results:
- task:
type: information-retrieval
name: Information Retrieval
dataset:
name: eval
type: eval
metrics:
- type: cosine_accuracy@1
value: 0.19753086419753085
name: Cosine Accuracy@1
- type: cosine_accuracy@3
value: 0.3117283950617284
name: Cosine Accuracy@3
- type: cosine_accuracy@5
value: 0.36728395061728397
name: Cosine Accuracy@5
- type: cosine_accuracy@10
value: 0.4074074074074074
name: Cosine Accuracy@10
- type: cosine_precision@1
value: 0.19753086419753085
name: Cosine Precision@1
- type: cosine_precision@3
value: 0.17901234567901234
name: Cosine Precision@3
- type: cosine_precision@5
value: 0.18271604938271604
name: Cosine Precision@5
- type: cosine_precision@10
value: 0.15987654320987654
name: Cosine Precision@10
- type: cosine_recall@1
value: 0.012537229433577907
name: Cosine Recall@1
- type: cosine_recall@3
value: 0.028172357070419075
name: Cosine Recall@3
- type: cosine_recall@5
value: 0.04616926987049525
name: Cosine Recall@5
- type: cosine_recall@10
value: 0.07464352973292211
name: Cosine Recall@10
- type: cosine_ndcg@10
value: 0.1771093240394393
name: Cosine Ndcg@10
- type: cosine_mrr@10
value: 0.2604485106799922
name: Cosine Mrr@10
- type: cosine_map@100
value: 0.10892177775157068
name: Cosine Map@100
- type: dot_accuracy@1
value: 0.1419753086419753
name: Dot Accuracy@1
- type: dot_accuracy@3
value: 0.2345679012345679
name: Dot Accuracy@3
- type: dot_accuracy@5
value: 0.26851851851851855
name: Dot Accuracy@5
- type: dot_accuracy@10
value: 0.33024691358024694
name: Dot Accuracy@10
- type: dot_precision@1
value: 0.1419753086419753
name: Dot Precision@1
- type: dot_precision@3
value: 0.13786008230452673
name: Dot Precision@3
- type: dot_precision@5
value: 0.13950617283950617
name: Dot Precision@5
- type: dot_precision@10
value: 0.1308641975308642
name: Dot Precision@10
- type: dot_recall@1
value: 0.005321414264515094
name: Dot Recall@1
- type: dot_recall@3
value: 0.019846033299858425
name: Dot Recall@3
- type: dot_recall@5
value: 0.029084171632431998
name: Dot Recall@5
- type: dot_recall@10
value: 0.049244765309017405
name: Dot Recall@10
- type: dot_ndcg@10
value: 0.13684384060235508
name: Dot Ndcg@10
- type: dot_mrr@10
value: 0.19590192043895757
name: Dot Mrr@10
- type: dot_map@100
value: 0.08815891364299847
name: Dot Map@100
SentenceTransformer based on microsoft/mdeberta-v3-base
This is a sentence-transformers model finetuned from microsoft/mdeberta-v3-base. It maps sentences & paragraphs to a 768-dimensional dense vector space and can be used for semantic textual similarity, semantic search, paraphrase mining, text classification, clustering, and more.
Model Details
Model Description
- Model Type: Sentence Transformer
- Base model: microsoft/mdeberta-v3-base
- Maximum Sequence Length: 512 tokens
- Output Dimensionality: 768 tokens
- Similarity Function: Cosine Similarity
Model Sources
- Documentation: Sentence Transformers Documentation
- Repository: Sentence Transformers on GitHub
- Hugging Face: Sentence Transformers on Hugging Face
Full Model Architecture
SentenceTransformer(
(0): Transformer({'max_seq_length': 512, 'do_lower_case': False}) with Transformer model: DebertaV2Model
(1): Pooling({'word_embedding_dimension': 768, 'pooling_mode_cls_token': False, 'pooling_mode_mean_tokens': True, 'pooling_mode_max_tokens': False, 'pooling_mode_mean_sqrt_len_tokens': False, 'pooling_mode_weightedmean_tokens': False, 'pooling_mode_lasttoken': False, 'include_prompt': True})
)
Usage
Direct Usage (Sentence Transformers)
First install the Sentence Transformers library:
pip install -U sentence-transformers
Then you can load this model and run inference.
from sentence_transformers import SentenceTransformer
# Download from the 🤗 Hub
model = SentenceTransformer("BlackBeenie/mdeberta-v3-base-sbert")
# Run inference
sentences = [
'hot dogs',
'Habitual physical exercise has beneficial effects on telomere length in postmenopausal women. OBJECTIVE: It has been reported that women benefit from the maintenance of telomere length by estrogen. Exercise may favorably influence telomere length, although results are inconsistent regarding the duration and type of exercise and the cell type used to measure telomere length. The purpose of this study was to investigate the relationship between habitual physical exercise and telomere length in peripheral blood mononuclear cells (PBMCs) in postmenopausal women. Postmenopausal women were chosen as study participants because they are typically estrogen deficient. METHODS: This experimental-control, cross-sectional study included 44 healthy, nondiabetic, nonsmoking, postmenopausal women. Habitual exercisers and sedentary participants were matched for age and body mass index. Body weight, height, blood pressure, and waist and hip circumference were measured. Mitochondrial DNA copy number and telomere length in PBMCs were determined, and biochemical tests were performed. Habitual physical exercise was defined as combined aerobic and resistance exercise performed for at least 60 minutes per session more than three times a week for more than 12 months. RESULTS: The mean age of all participants was 58.11 ± 6.84 years, and participants in the habitual exercise group had been exercising more than three times per week for an average of 19.23 ± 5.15 months. Serum triglyceride levels (P = 0.01), fasting insulin concentrations (P < 0.01), and homeostasis model assessment of insulin resistance (P < 0.01) were significantly lower and high-density lipoprotein cholesterol levels (P < 0.01), circulating adiponectin (P < 0.01), mitochondrial DNA copy number (P < 0.01), and telomere length (P < 0.01) were significantly higher in the habitual exercise group than in the sedentary group. In a stepwise multiple regression analysis, habitual exercise (β = 0.522, P < 0.01) and adiponectin levels (β = 0.139, P = 0.03) were the independent factors associated with the telomere length of PBMCs in postmenopausal women. CONCLUSIONS: Habitual physical exercise is associated with greater telomere length in postmenopausal women. This finding suggests that habitual physical exercise in postmenopausal women may reduce telomere attrition.',
'Dietary modification of human macular pigment density. PURPOSE: The retinal carotenoids lutein (L) and zeaxanthin (Z) that form the macular pigment (MP) may help to prevent neovascular age-related macular degeneration. The purpose of this study was to determine whether MP density in the retina could be raised by increasing dietary intake of L and Z from foods. METHODS: Macular pigment was measured psychophysically for 13 subjects. Serum concentrations of L, Z, and beta-carotene were measured by high-performance liquid chromatography. Eleven subjects modified their usual daily diets by adding 60 g of spinach (10.8 mg L, 0.3 mg Z, 5 mg beta-carotene) and ten also added 150 g of corn (0.3 mg Z, 0.4 mg L); two other subjects were given only corn. Dietary modification lasted up to 15 weeks. RESULTS: For the subjects fed spinach or spinach and corn, three types of responses to dietary modification were identified: Eight "retinal responders" had increases in serum L (mean, 33%; SD, 22%) and in MP density (mean, 19%; SD, 11%); two "retinal nonresponders" showed substantial increases in serum L (mean, 31%) but not in MP density (mean, -11%); one "serum and retinal nonresponder" showed no changes in serum L, Z, or beta-carotene and no change in MP density. For the two subjects given only corn, serum L changed little (+11%, -6%), but in one subject serum Z increased (70%) and MP density increased (25%). CONCLUSIONS: Increases in MP density were obtained within 4 weeks of dietary modification for most, but not all, subjects. When MP density increased with dietary modification, it remained elevated for at least several months after resuming an unmodified diet. Augmentation of MP for both experimental and clinical investigation appears to be feasible for many persons.',
]
embeddings = model.encode(sentences)
print(embeddings.shape)
# [3, 768]
# Get the similarity scores for the embeddings
similarities = model.similarity(embeddings, embeddings)
print(similarities.shape)
# [3, 3]
Evaluation
Metrics
Information Retrieval
- Dataset:
eval
- Evaluated with
InformationRetrievalEvaluator
Metric | Value |
---|---|
cosine_accuracy@1 | 0.1975 |
cosine_accuracy@3 | 0.3117 |
cosine_accuracy@5 | 0.3673 |
cosine_accuracy@10 | 0.4074 |
cosine_precision@1 | 0.1975 |
cosine_precision@3 | 0.179 |
cosine_precision@5 | 0.1827 |
cosine_precision@10 | 0.1599 |
cosine_recall@1 | 0.0125 |
cosine_recall@3 | 0.0282 |
cosine_recall@5 | 0.0462 |
cosine_recall@10 | 0.0746 |
cosine_ndcg@10 | 0.1771 |
cosine_mrr@10 | 0.2604 |
cosine_map@100 | 0.1089 |
dot_accuracy@1 | 0.142 |
dot_accuracy@3 | 0.2346 |
dot_accuracy@5 | 0.2685 |
dot_accuracy@10 | 0.3302 |
dot_precision@1 | 0.142 |
dot_precision@3 | 0.1379 |
dot_precision@5 | 0.1395 |
dot_precision@10 | 0.1309 |
dot_recall@1 | 0.0053 |
dot_recall@3 | 0.0198 |
dot_recall@5 | 0.0291 |
dot_recall@10 | 0.0492 |
dot_ndcg@10 | 0.1368 |
dot_mrr@10 | 0.1959 |
dot_map@100 | 0.0882 |
Training Details
Training Dataset
Unnamed Dataset
- Size: 110,575 training samples
- Columns:
sentence_0
,sentence_1
, andlabel
- Approximate statistics based on the first 1000 samples:
sentence_0 sentence_1 label type string string int details - min: 3 tokens
- mean: 6.46 tokens
- max: 19 tokens
- min: 27 tokens
- mean: 394.71 tokens
- max: 512 tokens
- 1: 100.00%
- Samples:
sentence_0 sentence_1 label chronic diseases
Role of antioxidants in cancer therapy. Oxidative stress is a key component in linking environmental toxicity to the multistage carcinogenic process. Reactive oxygen species (ROS) are generated in response to both endogenous and exogenous stimuli. To counterbalance ROS-mediated injury, an endogenous antioxidants defense system exists; however, when oxidation exceeds the control mechanisms, oxidative stress arises. Chronic and cumulative oxidative stress induces deleterious modifications to a variety of macromolecular components, such as DNA, lipids, and proteins. A primary mechanism of many chemotherapy drugs against cancer cells is the formation of ROS, or free radicals. Radiotherapy is based on the fact that ionizing radiation destroys tumor cells. Radiotherapy induces direct lesions in the DNA or biological molecules, which eventually affect DNA. Free radicals produced by oncology therapy are often a source of serious side effects as well. The objective of this review is to provide information about the effects of antioxidants during oncology treatments and to discuss the possible events and efficacy. Much debate has arisen about whether antioxidant supplementation alters the efficacy of cancer chemotherapy. There is still limited evidence in both quality and sample size, suggesting that certain antioxidant supplements may reduce adverse reactions and toxicities. Significant reductions in toxicity may alleviate dose-limiting toxicities so that more patients are able to complete prescribed chemotherapy regimens and thus, in turn, improve the potential for success in terms of tumor response and survival. Copyright © 2013 Elsevier Inc. All rights reserved.
1
plant-based diets
Diet, infection and wheezy illness: lessons from adults. An increase in asthma and atopic disease has been recorded in many countries where society has become more prosperous. We have investigated two possible explanations: a reduction in childhood infections and a change in diet. In a cohort of people followed up since 1964, originally selected as a random sample of primary school children, we have investigated the relevance of family size and the common childhood infectious diseases to development of eczema, hay fever and asthma. Although membership of a large family reduced risks of hay fever and eczema (but not asthma), this was not explained by the infections the child had suffered. Indeed, the more infections the child had had, the greater the likelihood of asthma, although measles gave a modest measure of protection. We have investigated dietary factors in two separate studies. In the first, we have shown the risks of bronchial hyper-reactivity are increased seven-fold among those with the lowest intake of vitamin C, while the lowest intake of saturated fats gave a 10-fold protection. In the second, we have shown that the risk of adult-onset wheezy illness is increased five-fold by the lowest intake of vitamin E and doubled by the lowest intake of vitamin C. These results were supported by direct measurements of the vitamins and triglycerides in plasma. We have proposed that changes in the diet of pregnant women may have reflected those observed in the population as a whole and that these may have resulted in the birth of cohorts of children predisposed to atopy and asthma. The direct test of this is to study the diet and nutritional status of a large cohort of pregnant women and to follow their offspring forward. This is our current research.
1
liver health
Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. We tested the effects of feeding a diet very high in fiber from fruit and vegetables. The levels fed were those, which had originally inspired the dietary fiber hypothesis related to colon cancer and heart disease prevention and also may have been eaten early in human evolution. Ten healthy volunteers each took 3 metabolic diets of 2 weeks duration. The diets were: high-vegetable, fruit, and nut (very-high-fiber, 55 g/1,000 kcal); starch-based containing cereals and legumes (early agricultural diet); or low-fat (contemporary therapeutic diet). All diets were intended to be weight-maintaining (mean intake, 2,577 kcal/d). Compared with the starch-based and low-fat diets, the high-fiber vegetable diet resulted in the largest reduction in low-density lipoprotein (LDL) cholesterol (33% +/- 4%, P <.001) and the greatest fecal bile acid output (1.13 +/- 0.30 g/d, P =.002), fecal bulk (906 +/- 130 g/d, P <.001), and fecal short-chain fatty acid outputs (78 +/- 13 mmol/d, P <.001). Nevertheless, due to the increase in fecal bulk, the actual concentrations of fecal bile acids were lowest on the vegetable diet (1.2 mg/g wet weight, P =.002). Maximum lipid reductions occurred within 1 week. Urinary mevalonic acid excretion increased (P =.036) on the high-vegetable diet reflecting large fecal steroid losses. We conclude that very high-vegetable fiber intakes reduce risk factors for cardiovascular disease and possibly colon cancer. Vegetable and fruit fibers therefore warrant further detailed investigation. Copyright 2001 by W.B. Saunders Company
1
- Loss:
MultipleNegativesRankingLoss
with these parameters:{ "scale": 20.0, "similarity_fct": "cos_sim" }
Training Hyperparameters
Non-Default Hyperparameters
eval_strategy
: stepsper_device_train_batch_size
: 32per_device_eval_batch_size
: 32fp16
: Truemulti_dataset_batch_sampler
: round_robin
All Hyperparameters
Click to expand
overwrite_output_dir
: Falsedo_predict
: Falseeval_strategy
: stepsprediction_loss_only
: Trueper_device_train_batch_size
: 32per_device_eval_batch_size
: 32per_gpu_train_batch_size
: Noneper_gpu_eval_batch_size
: Nonegradient_accumulation_steps
: 1eval_accumulation_steps
: Nonetorch_empty_cache_steps
: Nonelearning_rate
: 5e-05weight_decay
: 0.0adam_beta1
: 0.9adam_beta2
: 0.999adam_epsilon
: 1e-08max_grad_norm
: 1num_train_epochs
: 3max_steps
: -1lr_scheduler_type
: linearlr_scheduler_kwargs
: {}warmup_ratio
: 0.0warmup_steps
: 0log_level
: passivelog_level_replica
: warninglog_on_each_node
: Truelogging_nan_inf_filter
: Truesave_safetensors
: Truesave_on_each_node
: Falsesave_only_model
: Falserestore_callback_states_from_checkpoint
: Falseno_cuda
: Falseuse_cpu
: Falseuse_mps_device
: Falseseed
: 42data_seed
: Nonejit_mode_eval
: Falseuse_ipex
: Falsebf16
: Falsefp16
: Truefp16_opt_level
: O1half_precision_backend
: autobf16_full_eval
: Falsefp16_full_eval
: Falsetf32
: Nonelocal_rank
: 0ddp_backend
: Nonetpu_num_cores
: Nonetpu_metrics_debug
: Falsedebug
: []dataloader_drop_last
: Falsedataloader_num_workers
: 0dataloader_prefetch_factor
: Nonepast_index
: -1disable_tqdm
: Falseremove_unused_columns
: Truelabel_names
: Noneload_best_model_at_end
: Falseignore_data_skip
: Falsefsdp
: []fsdp_min_num_params
: 0fsdp_config
: {'min_num_params': 0, 'xla': False, 'xla_fsdp_v2': False, 'xla_fsdp_grad_ckpt': False}fsdp_transformer_layer_cls_to_wrap
: Noneaccelerator_config
: {'split_batches': False, 'dispatch_batches': None, 'even_batches': True, 'use_seedable_sampler': True, 'non_blocking': False, 'gradient_accumulation_kwargs': None}deepspeed
: Nonelabel_smoothing_factor
: 0.0optim
: adamw_torchoptim_args
: Noneadafactor
: Falsegroup_by_length
: Falselength_column_name
: lengthddp_find_unused_parameters
: Noneddp_bucket_cap_mb
: Noneddp_broadcast_buffers
: Falsedataloader_pin_memory
: Truedataloader_persistent_workers
: Falseskip_memory_metrics
: Trueuse_legacy_prediction_loop
: Falsepush_to_hub
: Falseresume_from_checkpoint
: Nonehub_model_id
: Nonehub_strategy
: every_savehub_private_repo
: Falsehub_always_push
: Falsegradient_checkpointing
: Falsegradient_checkpointing_kwargs
: Noneinclude_inputs_for_metrics
: Falseeval_do_concat_batches
: Truefp16_backend
: autopush_to_hub_model_id
: Nonepush_to_hub_organization
: Nonemp_parameters
:auto_find_batch_size
: Falsefull_determinism
: Falsetorchdynamo
: Noneray_scope
: lastddp_timeout
: 1800torch_compile
: Falsetorch_compile_backend
: Nonetorch_compile_mode
: Nonedispatch_batches
: Nonesplit_batches
: Noneinclude_tokens_per_second
: Falseinclude_num_input_tokens_seen
: Falseneftune_noise_alpha
: Noneoptim_target_modules
: Nonebatch_eval_metrics
: Falseeval_on_start
: Falseeval_use_gather_object
: Falsebatch_sampler
: batch_samplermulti_dataset_batch_sampler
: round_robin
Training Logs
Epoch | Step | Training Loss | eval_cosine_map@100 |
---|---|---|---|
0.1447 | 500 | 3.4744 | - |
0.2894 | 1000 | 3.3463 | - |
0.4340 | 1500 | 3.2119 | - |
0.5787 | 2000 | 3.0852 | - |
0.7234 | 2500 | 2.9736 | - |
0.8681 | 3000 | 2.8964 | - |
1.0 | 3456 | - | 0.0628 |
1.0127 | 3500 | 2.8117 | - |
1.1574 | 4000 | 2.7464 | - |
1.3021 | 4500 | 2.6987 | - |
1.4468 | 5000 | 2.6423 | 0.0795 |
1.5914 | 5500 | 2.584 | - |
1.7361 | 6000 | 2.5438 | - |
1.8808 | 6500 | 2.4891 | - |
2.0 | 6912 | - | 0.0948 |
2.0255 | 7000 | 2.4555 | - |
2.1701 | 7500 | 2.442 | - |
2.3148 | 8000 | 2.4161 | - |
2.4595 | 8500 | 2.3882 | - |
2.6042 | 9000 | 2.3545 | - |
2.7488 | 9500 | 2.3274 | - |
2.8935 | 10000 | 2.3134 | 0.1082 |
3.0 | 10368 | - | 0.1089 |
Framework Versions
- Python: 3.10.12
- Sentence Transformers: 3.1.1
- Transformers: 4.44.2
- PyTorch: 2.4.1+cu121
- Accelerate: 0.34.2
- Datasets: 3.0.0
- Tokenizers: 0.19.1
Citation
BibTeX
Sentence Transformers
@inproceedings{reimers-2019-sentence-bert,
title = "Sentence-BERT: Sentence Embeddings using Siamese BERT-Networks",
author = "Reimers, Nils and Gurevych, Iryna",
booktitle = "Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing",
month = "11",
year = "2019",
publisher = "Association for Computational Linguistics",
url = "https://arxiv.org/abs/1908.10084",
}
MultipleNegativesRankingLoss
@misc{henderson2017efficient,
title={Efficient Natural Language Response Suggestion for Smart Reply},
author={Matthew Henderson and Rami Al-Rfou and Brian Strope and Yun-hsuan Sung and Laszlo Lukacs and Ruiqi Guo and Sanjiv Kumar and Balint Miklos and Ray Kurzweil},
year={2017},
eprint={1705.00652},
archivePrefix={arXiv},
primaryClass={cs.CL}
}