text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the lipid a region of the lps is responsible for classical pathway activation and the polysaccharide region responsible for properdin pathway activation . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
4,
11
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
26,
29
]
} |
the polysaccharide portion of the lps molecule exerts a modifying influence on the potential anticomplementary activity of the lipid a . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
34,
37
]
} | {
"id": "C0023767",
"name": "a",
"pos": [
133,
134
]
} |
these effector cells could kill any allogeneic target cells but failed to effect cytotoxicity on the target cells autologous to the responding cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
36,
46
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
143,
148
]
} |
the findings of the present investigation suggest that expression of cytotoxicity induced in mlc is not necessarily restricted to the target cells syngeneic to the stimulator cells , but can be extended to any allogeneic target cells by the indirect effect of soluble factor secreted from stimulated cells that causes a polyclonal activation of cytotoxic precursors in the responding cell populations . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
210,
220
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
384,
388
]
} |
the present findings also emphasize the need for caution in the use of heat-treated lymphocytes as innocent-bystander cells in mlc to provide additional cytotoxic specificities in the responder cells , since heat-treated cells alone can activate lymphocytes to cytotoxic effector cells that kill any allogeneic target cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
118,
123
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
300,
310
]
} |
several antisera raised against purified carcinoembryonic antigen ( cea ) were evaluated for their content of antibody cross-reactive with colon carcinoma antigen-iii ( cca-iii ) . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
8,
16
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
110,
118
]
} |
total porphyrin content was quantitated by fluorescence assay , and spectral studies indicated that more than 80 % of the porphyrin produced was protoporphyrin . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
6,
15
]
} | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
145,
159
]
} |
to evaluate the possible importance of the anion delivered with calcium , similar experiments were performed in 10 dogs with equivalent amounts of calcium gluconate ( 0.3 mg. of ca++ per kilogram of body weight per minute ) . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
64,
71
]
} | {
"id": "C0006699",
"name": "calcium gluconate",
"pos": [
147,
164
]
} |
a rapid , simple technique whereby erythrocytes transiently exposed to hypotonic hemoglobin preparations undergo exchange of endogenous for exogenous hemoglobin has now been applied to normal , hemoglobin a-containing erythrocytes into which hemoglobin s or hemoglobin c have been introduced . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
81,
91
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
194,
206
]
} |
the relative proportions of antibodies of different specificities within antisera raised to native staphylococcal nuclease have been studied in several strains of mice in which the antibody response has been shown to be under h-2-linked ir-gene control . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
28,
38
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
73,
81
]
} |
guinea pig peritoneal macrophages were demonstrated to bind selectively soluble 125i-fibrin and fibrin/fibrinogen complexes as compared with fibrinogen , fibrinogen degradation products , and fibrin degradation products . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
85,
91
]
} | {
"id": "C0163275",
"name": "fibrin degradation products",
"pos": [
192,
219
]
} |
requirements for the solubilization of immune aggregates by complement : assembly of a factor b-dependent c3-convertase on the immune complexes . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
60,
70
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
87,
95
]
} |
because the cpr value includes both c-peptide and antibody-bound proinsulin , separate determination of free c-peptide was done in 30 patients . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
65,
75
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
109,
118
]
} |
although growth hormone values were higher in patients in the poorly controlled group , there was no correlation between hgh and cpr . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
9,
23
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
121,
124
]
} |
the rapid regression of the signs of obstructive airway disease following open heart repair of the ventricular septal defect indicates that the lung disease observed in these infants is secondary to the ventricular septal defect , rather than a primary process . | NA | {
"id": "C0600260",
"name": "obstructive airway disease",
"pos": [
37,
63
]
} | {
"id": "C0024115",
"name": "lung disease",
"pos": [
144,
156
]
} |
patients were randomly assigned to a methadyl acetate clinic in which methadyl acetate was dispensed to patients three times per week or to a methadone clinic in which methadone was dispensed six days per week . | NA | {
"id": "C0025607",
"name": "methadyl acetate",
"pos": [
37,
53
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
168,
177
]
} |
spontaneously reported symptoms suggest that induction with methadyl acetate may be a more clinically variable phenomenon than induction with methadone . | NA | {
"id": "C0025607",
"name": "methadyl acetate",
"pos": [
60,
76
]
} | {
"id": "C0025605",
"name": "methadone",
"pos": [
142,
151
]
} |
the breakdown of proinsulin in the pancreatic beta cell yields insulin and c-peptide which are secreted in equimolar amounts . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
17,
27
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
63,
70
]
} |
the breakdown of proinsulin in the pancreatic beta cell yields insulin and c-peptide which are secreted in equimolar amounts . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
17,
27
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
75,
84
]
} |
six of eight patients had impaired pituitary prolactin secretion after administration of thyrotropin-releasing hormone and chlorpromazine , with preservation of other anterior pituitary functions . | NA | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
89,
100
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
167,
185
]
} |
we believe that these patients have three autoimmune diseases : hashimoto 's thyroiditis , graves 's thyroid disease and graves 's ophthalmopathy . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
42,
61
]
} | {
"id": "C0018213",
"name": "graves 's",
"pos": [
121,
130
]
} |
among the methods available for the midtrimester diagnosis of neural tube defects , it has been suggested that amniography be used to determine the presence of meningomyelocele . | NA | {
"id": "C0027794",
"name": "neural tube",
"pos": [
62,
73
]
} | {
"id": "C0025312",
"name": "meningomyelocele",
"pos": [
160,
176
]
} |
it was found that carbon steel intracanal instruments were affected more by the different modes of sterilization than were the stainless steel instruments . | NA | {
"id": "C0038239",
"name": "steel",
"pos": [
25,
30
]
} | {
"id": "C0038126",
"name": "stainless steel",
"pos": [
127,
142
]
} |
within the limits of a small sample size , and in the presence of obesity , insulin does not appear to play a predominant role in the genesis of hypertriglyceridemia in children with familial hypertriglyceridemia . | NA | {
"id": "C0020557",
"name": "hypertriglyceridemia",
"pos": [
145,
165
]
} | {
"id": "C0020480",
"name": "familial hypertriglyceridemia",
"pos": [
183,
212
]
} |
thus , in man as in the rat , ( 1 ) phenylalanine hydroxylase approaches physiologically significant levels at an earlier development stage than does tyrosine aminotransferase and ( 2 ) extrauterinization stimulates the synthesis of tyrosine aminotransferase but not of phenylalanine hydroxylase . | NA | {
"id": "C0041487",
"name": "tyrosine",
"pos": [
150,
158
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
242,
258
]
} |
newer catecholamines for treatment of heart failure and shock : an update on dopamine and a first look at dobutamine . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
6,
20
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
106,
116
]
} |
the effect is a specific one , and of all the anions tested only bromide causes a similar bathochromic shift . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
46,
52
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
65,
72
]
} |
diffusion coefficients ( d ) of a lipid probe and labeled proteins on l-6 myoblast membranes have been measured giving d ( protein ) approximately 2 x 10 ( -10 ) square centimeter per second and d ( lipid probe ) approximately 9 x 10 ( -9 ) square centimeter per second . | NA | {
"id": "C0025252",
"name": "proteins",
"pos": [
58,
66
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
123,
130
]
} |
unlike older children and adults , children of less than about 10 years of age remember photographs of faces presented upside down almost as well as those shown upright and are easily fooled by simple disguises . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
7,
21
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
35,
43
]
} |
xenopus laevis ribosomal dna and histone dna of psammechinus miliaris were ligated into pcri plasmids and screened by this method . | NA | {
"id": "C0012933",
"name": "ribosomal dna",
"pos": [
15,
28
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
41,
44
]
} |
the specificity of the phenomenon was demonstrated by the reversal obtained with the narcotic antagonists naloxone , naltrexone , and gpa 1843 ; | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
106,
114
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
117,
127
]
} |
larger molecules , such as the globulin fraction , did not consistently decrease during the first 45 minutes following shock , a possible indication that loss of this protein into the interstitial space did not occur in a consistent manner . | NA | {
"id": "C0017649",
"name": "globulin",
"pos": [
31,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
167,
174
]
} |
four patients are completely continent of urine , 1 has mild stress incontinence , and 1 is incontinent because of a neurogenic bladder . | NA | {
"id": "C0042025",
"name": "stress incontinence",
"pos": [
61,
80
]
} | {
"id": "C0042024",
"name": "incontinent",
"pos": [
92,
103
]
} |
triglyceride and total esterified fatty acid concentrations in pleural fluid were high on admission when feeded with human milk , and chylomicrons and other lipoproteins were present in the chyle . | NA | {
"id": "C0008731",
"name": "chylomicrons",
"pos": [
134,
146
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
157,
169
]
} |
one or more of the following observations may prove or disprove participation of a kent bundle during supraventricular tachycardia : ( 1 ) induction of a-v block during tachycardia : ( 2 ) influence of electrically induced ventricular premature beats upon tachycardia ; | NA | {
"id": "C0039240",
"name": "supraventricular",
"pos": [
102,
118
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
256,
267
]
} |
a high incidence of gallstones or previous cholecystectomy ( 36 % ) was found preoperatively and of 25 patients with normal cholecystograms , four developed stones and five had nonvisualization of gallbladder 6 to 12 months postoperatively . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
20,
30
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
157,
163
]
} |
given differences between the two states for increased intracellular hepatocyte redox potential and possibly different predominant sources for fatty acid mobilization and production affecting increased intracellular triglyceride synthesis , the remainder of the pathway proposed for the development of cirrhosis from ethanolic liver disease may equally apply to the cirrhosis seen in postbypass patients . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
327,
340
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
366,
375
]
} |
hepatic disease presents itself as : 1 ) acute hepatic failure , 2 ) insidious development of cirrhosis , or 3 ) tenous hepatic functional state that reduces hepatic resistance to other insults . | NA | {
"id": "C0023895",
"name": "hepatic disease",
"pos": [
0,
15
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
94,
103
]
} |
evidence is presented that many of the enteric and systemic manifestations after jejunoileal bypass can be related to an inflammatory process within the bypassed small bowel rather than to the surgically induced sequelae of a short bowel syndrome with malabsorption . | NA | {
"id": "C0036992",
"name": "short bowel",
"pos": [
226,
237
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
252,
265
]
} |
there was a significant correlation between ch50 , c4 and c5 , but no correlation between factor b and any of the other indices of complement activity measured . | NA | {
"id": "C0033453",
"name": "factor b",
"pos": [
90,
98
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
131,
141
]
} |
it is concluded that there is only one pertinent difference among the tetracyclines , namely , that doxycycline , and probably minocycline , can be given in full dosage and with minimal risk to patients with renal impairment . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
70,
83
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
100,
111
]
} |
it is concluded that there is only one pertinent difference among the tetracyclines , namely , that doxycycline , and probably minocycline , can be given in full dosage and with minimal risk to patients with renal impairment . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
70,
83
]
} | {
"id": "C0026187",
"name": "minocycline",
"pos": [
127,
138
]
} |
there are no important differences in therapeutic effect among oxacillin , cloxacillin , dicloxacillin or flucloxacillin by the oral route , or among oxacillin , dicloxacillin , nafcillin or methicillin parenterally . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
75,
86
]
} | {
"id": "C0016267",
"name": "flucloxacillin",
"pos": [
106,
120
]
} |
there are no important differences in therapeutic effect among oxacillin , cloxacillin , dicloxacillin or flucloxacillin by the oral route , or among oxacillin , dicloxacillin , nafcillin or methicillin parenterally . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
75,
86
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
166,
175
]
} |
there are no important differences in therapeutic effect among oxacillin , cloxacillin , dicloxacillin or flucloxacillin by the oral route , or among oxacillin , dicloxacillin , nafcillin or methicillin parenterally . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
75,
86
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
162,
175
]
} |
although the infant birth weight was unrelated to the serum level of the three proteins , both the hpl and o concentrations were significantly correlated with the placental weight in the normal pregnancies . | NA | {
"id": "C0005612",
"name": "infant birth",
"pos": [
13,
25
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
173,
179
]
} |
the present studies were designed to estimate fetal weight on the basis of the thesis that the factors which determine body weight include the fetal bone and the amount of fetal soft tissue , i.e. , fetal corpulence . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
46,
58
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
119,
130
]
} |
in this study , the enzyme responsible for active sodium transport -- na/k-atpase and a nonspecific atpase mg-atpase -- were assayed in the placenta and in maternal and fetal ( cord ) erythrocytes of pregnant women with and without pre-eclampsia . | NA | {
"id": "C0001479",
"name": "na/k-atpase",
"pos": [
70,
81
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
110,
116
]
} |
the results in 11 patients with midtrimester pregnancy and step-up increase of ot infusion by 20 mu . showed a positive correlation of the increase of plasma ot and uterine contractility only at the plasma ot levels of 20 to 60 muu . per milliliter and only with hypertonic contractility but no correlation at plasma levels below and above this range . | NA | {
"id": "C0032980",
"name": "midtrimester",
"pos": [
32,
44
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
45,
54
]
} |
the antiserum was used in studies of lymphocytes in chronic and acute lymphocytic leukemias , lymphomas , and other lymphoproliferative diseases . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
94,
103
]
} | {
"id": "C0024314",
"name": "lymphoproliferative diseases",
"pos": [
116,
144
]
} |
the availability of purified acinar cells in the investigation of interactions between hormones and cells from the mammary gland permits a greater degree of specificity than has been possible in the study of mammary cell suspensions which contain myoepithelial cells , duct cells , acinar cells , endothelial cells , fibroblasts , fat cells , mast cells , plasma cells , and blood cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
36,
41
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
317,
328
]
} |
premature activation of proteolytic zymogens ( trypsinogen , chymotrypsinogen ) as an early step in the pathogenesis of exocrine pancreatic insufficency ( epi ) syndrome in cba/j mice was investigated in electrophoresed pancreatic homogenates . | NA | {
"id": "C0014436",
"name": "zymogens",
"pos": [
36,
44
]
} | {
"id": "C0041243",
"name": "trypsinogen",
"pos": [
66,
77
]
} |
premature activation of proteolytic zymogens ( trypsinogen , chymotrypsinogen ) as an early step in the pathogenesis of exocrine pancreatic insufficency ( epi ) syndrome in cba/j mice was investigated in electrophoresed pancreatic homogenates . | NA | {
"id": "C0014436",
"name": "zymogens",
"pos": [
36,
44
]
} | {
"id": "C0008746",
"name": "chymotrypsinogen",
"pos": [
61,
77
]
} |
the diagnosis of acrodysostosis has been differentiated from that of pseudohypoparathyroidism or pseudo-pseudohypoparathyroidism by the absence of endocrine abnormalities , more generalized osseous abnormalities , and a characteristic facial appearance . | NA | {
"id": "C0033806",
"name": "pseudohypoparathyroidism",
"pos": [
69,
93
]
} | {
"id": "C0033835",
"name": "pseudo-pseudohypoparathyroidism",
"pos": [
97,
128
]
} |
hypotension was induced with intravenous infusions of sodium nitroprusside and trimethaphan for 5-16 min to produce comparable reductions of mean arterial pressure ( 32 mm hg or 26 per cent with nitroprusside and 37 mm hg or 31 per cent with trimethaphan ) . | NA | {
"id": "C0037533",
"name": "sodium",
"pos": [
54,
60
]
} | {
"id": "C0028193",
"name": "nitroprusside",
"pos": [
195,
208
]
} |
skin findings , such as transient blanching or erythema in a neonate who has had umbilical artery catheterization , can precede the evolution of gangrene and necrosis . | NA | {
"id": "C0017086",
"name": "gangrene",
"pos": [
145,
153
]
} | {
"id": "C0027540",
"name": "necrosis",
"pos": [
158,
166
]
} |
as a result of the large number of pancreatectomies performed , there was also a large number of postoperative complications , the most frequent being leakage at an anastomotic line . | NA | {
"id": "C0032787",
"name": "postoperative complications",
"pos": [
97,
124
]
} | {
"id": "C0919691",
"name": "leakage",
"pos": [
151,
158
]
} |
mannosidosis is a rare inborn error of metabolism characterized by deficiency of the lysosomal enzyme alpha-mannosidase and widespread storage of complex carbohydrate , which is enriched in mannose . | NA | {
"id": "C1257960",
"name": "mannosidosis",
"pos": [
0,
12
]
} | {
"id": "C0024748",
"name": "deficiency of",
"pos": [
67,
80
]
} |
the endolymphatic sac ( els ) and vestibular aqueduct ( va ) , which play a notable role in the pathogenesis of endolymphatic hydrops and meniere disease , were identified in all anatomic and tomographic materials . | NA | {
"id": "C0206586",
"name": "endolymphatic hydrops",
"pos": [
112,
133
]
} | {
"id": "C0025281",
"name": "meniere disease",
"pos": [
138,
153
]
} |
yeast hexokinase isozymes p1 and p11 exhibit a ph dependent , rapid relaxation process at 15 degrees c at enzyme concentrations of 100-474 mum and over a ph range of 6-8 . | NA | {
"id": "C0022173",
"name": "isozymes",
"pos": [
17,
25
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
106,
112
]
} |
osmium tetroxide in the presence of pyridine or 2,2'-bipyridine has been found to react completely with the pyrimidine moieties ( thymine , uracil , and cytosine ) in polynucleotides . | NA | {
"id": "C0040087",
"name": "thymine",
"pos": [
130,
137
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
140,
146
]
} |
yeast poly ( adenylic acid ) -containing messenger rna was isolated from total cellular rna by affinity chromatography on poly ( uridylic acid ) -cellulose . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
41,
54
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
88,
91
]
} |
the irreversible inhibition of chloroplast phosphorylation by either sulfate anions , or n-ethylmaleimide , is energy dependent . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
69,
76
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
77,
83
]
} |
( 1 ) the matrix concentration of divalent cations has been calculated from the total cation uptake , from the increase of matrix volume and from the esr sextet signal of mn ( h2o ) l2+ . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
34,
50
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
86,
92
]
} |
after essentially complete inactivation of the ( ca2+ + mg2+ ) -atpase by treatment of ghosts with phospholipase c from bacillus cereus , the enzyme is reactivated by the addition of any of the glycerophospholipids , phosphatidylserine , phosphatidylcholine , phosphatidylethanolamine or lysophosphatidylcholine , but not by addition of sphingomyeline , free fatty acids or the detergent triton x-100 . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
194,
214
]
} | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
292,
311
]
} |
after essentially complete inactivation of the ( ca2+ + mg2+ ) -atpase by treatment of ghosts with phospholipase c from bacillus cereus , the enzyme is reactivated by the addition of any of the glycerophospholipids , phosphatidylserine , phosphatidylcholine , phosphatidylethanolamine or lysophosphatidylcholine , but not by addition of sphingomyeline , free fatty acids or the detergent triton x-100 . | NA | {
"id": "C0162448",
"name": "glycerophospholipids",
"pos": [
194,
214
]
} | {
"id": "C0031618",
"name": "phosphatidylethanolamine",
"pos": [
260,
284
]
} |
the influence of well-defined changes in the polar part of phospholipid molecules on the properties of black lipid membranes was studied using a series of phospholipids with identical hydrocarbon chains , but systematically changed polar groups . | NA | {
"id": "C0025249",
"name": "lipid membranes",
"pos": [
109,
124
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
155,
168
]
} |
our results indicate that the diffusion water permeability is constant over a large range of osmolality ( 300-1000 mosm ) produced by the permeable solutes urea , methanol , ethanol , and glycerol . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
163,
171
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
174,
181
]
} |
other amino acids recognized as principally reactive with systems a or l yielded corresponding inhibitory effects with some conspicious exceptions : 2-aminoisobutyric acid and even glycine become better substrates of system l as the ph is lowered ; | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
6,
11
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
181,
188
]
} |
the dicarboxylic amino acids take the sequence , aspartic acid less than glutamic acid less than alpha-aminoadipic acid less than s-carboxymethylcysteine , in their rate of mediated , na+-independent uptake at low ph . | NA | {
"id": "C0002524",
"name": "dicarboxylic amino acids",
"pos": [
4,
28
]
} | {
"id": "C0000257",
"name": "alpha-aminoadipic acid",
"pos": [
97,
119
]
} |
even then it is the presence of the carbonyl group and not of the intact carboxyl group nor of its hydroxyl group that cancels out the stereospecificity , as was shown by the absence of normal stereospecificity for aspartic acid and asparagine and its presence in glutamic acid , homoserine and glutamine . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
264,
272
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
295,
304
]
} |
chemically transformed syrian hamster cells exhibit marked agglutination in the presence of the plant lectin , concanavalin a . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
96,
108
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
111,
125
]
} |
the amount of a low molecular weight dna polymerase extractable with the cytoplasmic fraction , possibly dna polymerase beta , is low in erythroblasts , increases in the more mature erythroid population and then declines to an undectable level in the fully mature erythrocytes . | NA | {
"id": "C0012892",
"name": "dna polymerase",
"pos": [
37,
51
]
} | {
"id": "C0525039",
"name": "dna polymerase beta",
"pos": [
105,
124
]
} |
the 0.56 x 10 ( 6 ) mr plastid rrna is the one species of rna most affected by metabolic shifts ; | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
31,
35
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
58,
61
]
} |
the kinetics of competition of pairs of two substrates for bovine erythrocyte acetylcholinesterase ( acetylcholine hydrolase , ec 3.1.1.7 ) and horse serum cholinesterase ( acylcholine acyl-hydrolase , ec 3.1.1.8 ) was studied so that the hydrolysis of only one substrate was measured at a time . | NA | {
"id": "C0001044",
"name": "acetylcholine hydrolase",
"pos": [
101,
124
]
} | {
"id": "C0008429",
"name": "acylcholine acyl-hydrolase",
"pos": [
173,
199
]
} |
kinetic investigations of the ca2+-atpase and mg2+-atpase ( atp phosphohydrolases , ec 3.6.1.3 ) at ph 8.0 gave km and v values of 17.3 mum and 1.25 mumol pi/min per mg , and 2.4 mum and 0.12 mumol pi/min per mg , respectively . | NA | {
"id": "C0001476",
"name": "ca2",
"pos": [
30,
33
]
} | {
"id": "C0001473",
"name": "atp",
"pos": [
60,
63
]
} |
kinetic investigations of the ca2+-atpase and mg2+-atpase ( atp phosphohydrolases , ec 3.6.1.3 ) at ph 8.0 gave km and v values of 17.3 mum and 1.25 mumol pi/min per mg , and 2.4 mum and 0.12 mumol pi/min per mg , respectively . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
46,
49
]
} | {
"id": "C0001473",
"name": "atp",
"pos": [
60,
63
]
} |
for a specific concentration , the serum viscosity was highest in patients with igm proteins and lowest in patients with igg globulins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
84,
92
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
125,
134
]
} |
the dopamine hypothesis of schizophrenia proposes that schizophrenia is associated with increased brain dopaminergic function . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
4,
12
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
104,
116
]
} |
understanding the mechanisms of disease in order to be able to relate clinical symptoms and signs to physiologic and pathologic processes is emphasized . | NA | {
"id": "C0012634",
"name": "disease",
"pos": [
32,
39
]
} | {
"id": "C0030660",
"name": "pathologic",
"pos": [
117,
127
]
} |
the tumors included a right optic nerve glioma , a pilocytic astrocytoma in the right globus pallidus , a ganglioglioma in the left globus pallidus and a medulloblastoma in the cerebellum . | NA | {
"id": "C0017638",
"name": "glioma",
"pos": [
40,
46
]
} | {
"id": "C0206716",
"name": "ganglioglioma",
"pos": [
106,
119
]
} |
the tumors included a right optic nerve glioma , a pilocytic astrocytoma in the right globus pallidus , a ganglioglioma in the left globus pallidus and a medulloblastoma in the cerebellum . | NA | {
"id": "C0017638",
"name": "glioma",
"pos": [
40,
46
]
} | {
"id": "C0025149",
"name": "medulloblastoma",
"pos": [
154,
169
]
} |
when cultures were exposed to 43 degrees heat in s phase , intracellular amounts of spermidine and spermine were again reduced and increased extracellular levels of these polyamines were observed . | NA | {
"id": "C0037871",
"name": "intracellular",
"pos": [
59,
72
]
} | {
"id": "C0037874",
"name": "spermine",
"pos": [
99,
107
]
} |
( b ) exposure of either g1- or s-phase cultures to 43 degrees heat caused a depression of bulk dna-synthetic rates resulting in a prolongation of s phase , and ( c ) the intracellular reaccumulation of spermidine and spermine following exposure of g1 cells to a 43 degrees heat shock is temporally related to the recovery of near-normal dna synthetic rates in these cells . | NA | {
"id": "C0037871",
"name": "intracellular",
"pos": [
171,
184
]
} | {
"id": "C0037874",
"name": "spermine",
"pos": [
218,
226
]
} |
when human diploid fibroblasts ( wi-38 cells ) in culture are maintained under conditions nonpermissive for growth ( serum restriction ) , cell proliferation ceases but the cells remain viable for extended periods of time . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
19,
30
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
173,
178
]
} |
in order to determine the responding cell type ( s ) in this reaction , lymph node and spleen cell populations were specifically depleted of thymus- or bone marrow-derived cells by the use of the appropriate antisera and complement or by immunoadsorption of the fc receptor-bearing cells to antibody-coated sheep red blood cell monolayers . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
208,
216
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
291,
299
]
} |
the sensitivity of this assay was such that ara-c , 0.02 mug/ml , in plasma could be detected , and the assay was practically free from interference by deoxycytidine , cytidine , 1-beta-d-arabinofuranosyluracil , and other nucleosides , as well as from various antibiotics . | NA | {
"id": "C0011485",
"name": "deoxycytidine",
"pos": [
152,
165
]
} | {
"id": "C0010715",
"name": "cytidine",
"pos": [
168,
176
]
} |
if the dietary cholesterol effects a similar inhibition in vivo , the cholesterol-dependent osmium staining could be due to precursors ( s ) of cholesterol accumulating in the intracellular sites described . | NA | {
"id": "C0008395",
"name": "dietary",
"pos": [
7,
14
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
144,
155
]
} |
with all the three techniques used it was demonstrated that the sodium-potassium-activated adenosine triphosphatase ( nak-atpase ) activity is localized in the cell membranes of the endothelium whereas a much weaker activity was observed in the epithelium . | NA | {
"id": "C0001479",
"name": "sodium-potassium",
"pos": [
64,
80
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
122,
128
]
} |
dobutamine is a newly developed catecholamine reported to have minimal direct vascular effects relative to its inotropic activity and to have less chronotropic and arrhythmogenic properties than other catecholamines used in the treatment of low output states . | NA | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
0,
10
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
201,
215
]
} |
this procedure , compared with the gas-chromatographic procedure of kupferberg [ clin . chim . acta 29 , 283 ( 1970 ) ] , gave a weighted regression line -- forced through the origin -- of y= ( 1.01+/-0.04 ) x for phenobarbital , y= ( 0.95+/-0.04 ) x for primidone . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
214,
227
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
255,
264
]
} |
within-run coefficients of variation based on single determinations were 9,11 , and 22 % for primidone , phenobarbital , and phenytoin , respectively . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
93,
102
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
105,
118
]
} |
run-to-run assay cv was 6 % for primidone and phenobarbital and 13 % for phenytoin , based on the means of triplicate determinations of a sample with a mid-range concentration . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
32,
41
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
46,
59
]
} |
the results demonstrate that the well-known lack of sensitivity of these strips to proteins other than albumin relates to the number and affinity of binding sites on these proteins as compared to albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
83,
91
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
196,
203
]
} |
the data suggest that these test strips can screen more effectively for albuminuria than for other proteinurias . | NA | {
"id": "C0001925",
"name": "albuminuria",
"pos": [
72,
83
]
} | {
"id": "C0033687",
"name": "proteinurias",
"pos": [
99,
111
]
} |
the polyamines , spermidine and spermine , and their diamine precursor , putrescine , constitute a unidirectional biosynthetic pathway whose biosynthetic enzymes and accumulation patterns appear to play important roles in the regulation of growth processes . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
4,
14
]
} | {
"id": "C0011957",
"name": "diamine",
"pos": [
53,
60
]
} |
concentrations of these compounds in physiological fluids are low or undetectable under normal conditions , are elevated in patients with metastatic cancer , and are thought to reflect growth ( putrescine concentrations ) and cell turnover ( spermidine concentrations ) of the organism . | NA | {
"id": "C0034170",
"name": "putrescine",
"pos": [
194,
204
]
} | {
"id": "C0037871",
"name": "concentrations",
"pos": [
253,
267
]
} |
with the purified myoglobin and antisera , we then developed a radioimmunoassy that involves simultaneous regent addition , a 3.5-h incubation at 37 degrees c , and separation of the antibody-bound fraction by precipitation with polyethylene glycol . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
32,
40
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
183,
191
]
} |
we measured the concentrations of phenobarbital , phenytoin , primidone , ethosuximide , antipyrine , and caffeine in paired samples of saliva and plasma by gas chromatograph-mass spectrometer-computer ( gc/ms/com ) and enzyme immunoassay . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
34,
47
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
62,
71
]
} |
mixed saliva was collected for the antipyrine and caffeine studies , parotid saliva for the phenobarbital , primidone , ethosuximide and phenytoin studies . | NA | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
92,
105
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
108,
117
]
} |